These patients all underwent further evaluation of their pulmonary and allergic history and all 3 were challenged with aspirin.


Slow acetylators, who comprise roughly 50% of the South African population, are likely to develop clinical and biochemical features of phenytoin toxicity when this drug is given together with antituberculosis therapy.


Acute diurnal variations of the pharmacodynamic striatal response are suggested explanation for these clinical observations.


Thrombolytic therapy may be a two-edged sword and therefore early angiography should be considered in making the diagnosis and choosing the therapy.


SMS 201-995 is active orally at doses of 4-8 mg and when given thrice-daily to 6 patients with active acromegaly, suppressed mean 24-h growth hormone levels by 51-88%.


Amlodipine and the nitroglycerin patch were discontinued and propafenone decreased to 450 mg/d; citalopram was continued at 20 mg/d.


The patient was doing well at 6 months follow-up.


Diazepam use by pregnant women can be associated with a later presentation of withdrawal symptoms in the neonate than that induced by the use of other drugs.


She was then placed on 1-month recall for the next 4 months.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


Fatal spontaneous spinal epidural hematoma following thrombolysis for myocardial infarction.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.


Catheter-directed thrombolysis (CDT) has only been described in context with free-tissue transfer in a case of distal bypass salvage.


The hyperdense MCA lesion had resolved on the 24-hour follow-up scan.


The authors describe two cases of paranoid confusional psychosis commencing 1 week after the patients' withdrawal from sympathomimetic amines.


After 10 d cholinesterase was still low and liver enzymes were elevated.


RESULTS: A complete response (CR) was obtained for all three patients, resulting in a response rate of 100%.


CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.


Various reports show the use of MELISA (memory lymphocyte immunostimulation assay) and patch tests in determining mercury sensitivity.


Although Sweet's syndrome and SPE are rare diseases, the presence of these diseases must be considered when performing chemotherapy for urological malignancy.


Three ovarian thecomas, which are considered to be estrogenic tumors, were associated with endometrial malignant mullerian mixed tumor, mullerian adenosarcoma, and low-grade stromal sarcoma in postmenopausal women.


An extrapyramidal reaction was suspected and diphenhydramine 50 mg was administered without effect.


A case of a 32-year-old woman with aquagenic syringeal acrokeratoderma is presented.


Cataracts induced by intermittent Decadron used as an antiemetic.


Acute pancreatitis is a rare but severe complication of TACE.


Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.


Thus, if further studies confirm these effects, telmisartan may be the anti-hypertensive drug of first choice in HIV-infected subjects on combined antiretroviral therapy affected with diabetes and metabolic disorders.


OBJECTIVE: To raise awareness of a rare but serious adverse effect of a commonly used medication.


5-Fluorouracil (5-FU) is an analogue of pyrimidine nucleosides that is widely used in the treatment of head and neck, breast, ovarian, and colon cancer.


We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).


During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.


This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.


The patient was admitted to the intensive care unit for treatment of respiratory failure, where oxygen was delivered by face mask.


MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.


The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced "jitteriness" may be identical.


In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.


Need for an urgent ultrasound examination for neck lump.


One tablet from 1 of the patient's levothyroxine prescriptions was assayed, and its levothyroxine content was 74.5% of the label claim, a value outside of the United States Pharmacopeia requirements of 90-110%.


Effects of the methylprednisolone pulse therapy on renal function.


Combination antidepressant therapy in primary care.


METHODS: We performed a clinical chart review.


The amount of weight loss was substantial in this group of patients, ranging from 19 pounds to 53 pounds.


RESULTS: Budesonide use can cause contact dermatitis.


To our knowledge, this is the first case reported in the English literature of a generalized exanthem due to subcutaneous injection of enoxaparin.


Dose-intensive chemotherapy with intravenous melphalan and growth-factor-mobilized blood stem cell support is feasible therapy for patients with AL amyloidosis, even when there is clinical evidence of cardiac involvement.


OBJECTIVES: To describe the dissolution of a large organized intraatrial catheter-tip thrombus using a novel aggressive dose escalation of tissue plasminogen activator infusion.


Future prospective controlled trials are needed to determine the efficacy, safety, tolerability, and possibly the optimal dose and timing of rFVIIa administration.


Alopecia does rarely develop in the convalescent status of phenobarbital-induced AHS after stopping phenobarbital and its mechanism is related to lymphocyte infiltration into the peri-bulbar, supra-bulbar and peri-follicular regions.


In addition to improving insulin sensitivity, they generally result in a modest elevation of plasma HDL cholesterol.


Sensorimotor polyneuropathy with 5-aminosalicylic acid: a case report.


Systemic lupus erythematosus (SLE) developed in as 23-year-old woman with psoriasis during treatment with psoralen-ultraviolet-A (PUVA).


The diagnosis of lead toxicity is often delayed and abdominal pain is mistaken for acute abdomen.


All three were doing well at the time of follow-up evaluation, and there was no evidence of structural heart disease.


No chronic GVHD occurred.


In vivo confocal microscopy is a useful tool to study interlamellar stromal keratopathy induced by elevated IOP after LASIK in humans and the response to treatment and to differentiate interlamellar stromal keratopathy from DLK.


Using this approach, we observed normal haemostasis, and there were no signs of excessive postoperative bleeding or wound haematoma.


The cardiac toxicity of HCQ has focused primarily on acute intoxication.


This may be particularly useful in the patient with asymptomatic pharyngoesophageal diverticulum (Zenker diverticulum).


Effective therapy of HIT involves both the prompt recognition of the syndrome and its proper management.


MR findings in methotrexate-induced CNS abnormalities.


Since toxicity develops with a remarkable delay, early removal of the drug (by hemodialysis) could possibly prevent central nervous toxicity.


It is likely that the selective nephrotoxicity in these 3 patients with SIADH was induced by tetracycline.


In this case, a 51-year-old woman presented with several weeks of left shoulder pain and was diagnosed with rotator cuff tendonitis.


The prevalence of use, demographics of a treatment population, and occurrence of a particular side effect are explored in this article.


This case illustrates the importance of screening for parasitic infections before transplantation in the appropriate clinical setting, and demonstrates the utility of direct diagnostic evaluation for parasitic infections in at-risk post-transplant patients with unexplained illnesses.


Acute pancreatitis associated with danazol treatment for endometriosis.


Severe bleomycin lung toxicity: reversal with high dose corticosteroids.


The only comparable case previously reported (Lai et al., 1991) showed close similarities in the clinical, biological and histological manifestations with microvesicular steatosis.


Toxicity associated with barracuda is discussed.


Heparin was replaced by argatroban on the 13th day.


It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.


Co-trimoxazole red cell aplasia in leukaemia.


DISCUSSION: Cough induced by ACE inhibitors is a frequently documented adverse effect.


Steroid therapy for ureteral obstruction after aortoiliac graft surgery.


One patient with nasopharyngeal undifferentiated carcinoma and 1 patient with maxillary adenosquamous carcinoma showed complete response (CR), while all SCC patients showed stable disease (SD) or progressive disease (PD).


Hypotension and sinus arrest with nifedipine in pulmonary hypertension.


However, extracutaneous lesions are common, and the gastrointestinal tract is often involved.


Fatal acute neurotoxicity is rarely encountered.


Patients treated with captopril who develop "atypical cholangitis" should be suspected of having captopril-associated liver damage.


The duration of the pauses were equal or almost equal to one short plus one long P-P interval or to twice the basic sinus cycle.


Dentists need to be alert to the risk that patients may not reveal their true medical history.


Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature.


Total body computed tomography scan did not reveal any mucosal or visceral lesion.


During the disease course, the patient showed a transient increase in anti-human herpesvirus (HHV)-6 antibody titers and HHV-6 DNA in the peripheral blood, indicating the reactivation of a latent HHV-6 infection.


This report presents a potential case of risperidone-induced tardive dyskinesia.


Subacromial injections have been used to treat rotator cuff problems.


Gingival hemorrhage, myelodysplastic syndromes, and acute myeloid leukemia.


Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.


OBJECTIVE: To describe the use of botulinum toxin injection of the lacrimal gland for palliative treatment of epiphora secondary to canalicular obstruction from docetaxel therapy.


Neurological diseases have been rarely described as adverse events of anti-TNF agents.


This is the first case of hydroxyurea-induced acute interstitial pneumonitis reported in the literature.


Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.


Aquagenic pruritus is a rare but distinct entity in which intense itching develops after contact with water, in the absence of cutaneous signs or underlying disorders that could explain the symptoms.


Similar cases of this reaction have been reported with procainamide, which is structurally similar to metoclopramide.


All patients had significant renal insufficiency.


The patient's receipt of concurrent anti-TNF-alpha therapy and other immunosuppressive therapy while she was living in an area where histoplasmosis was endemic was thought to be the most likely explanation for the infection; the evidence presented suggests that this fatal infection was unlikely to have been related to exposure to the agent administered in the gene-therapy trial.


We report the cases of two patients, previously operated for mitral mechanical valve replacement who developed thrombosis of the prosthesis.


The baby had an excellent recovery and was discharged home after a prolonged antibiotic course.


Except for 3 mild infections around the catheter exit site, there have been no complications of this therapy is 58 cumulative patient weeks.


Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.


These changes resemble lymphocytic bronchiolitis in lung transplant recipients, which was well correlated with HRCT findings.


Anterior spinal artery syndrome--a complication of cervical intrathecal phenol injection.


Bronchial exposure to alternative sprays containing beclomethasone dipropionate (group D), fluticasone-17- propionate (D) and dexamethasone-21-isonicotinate (C) was well tolerated.


She began to recover after 10 days of supportive therapy and was discharged several weeks later on primidone therapy.


Didanosine (ddl) was the most common ART drug being used by 4 patients.


PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.


The syndrome, diagnostic modalities, and therapeutic options are reviewed.


OBJECTIVES: A 56-year-old man developed an erythematous, circle-shaped lesion on his penis.


She manifested all the clinical symptoms and signs of caffeine toxicity.


Losartan-induced angioedema.


Cutaneous necrosis as a result of interferon alfa is an infrequent complication with unknown pathogenesis, in which a cutaneous local immune-mediated inflammatory process might be involved.


Although RFA is generally well tolerated, recent studies have reported complications associated with RFA.


This case report describes successful lithium treatment in a patient with long-standing periodic catatonia.


A patient is reported who developed essential thrombocythemia after successful treatment for hairy cell leukemia.


Rifabutin therapy has been demonstrated to be effective in the treatment and prophylaxis of MAC infection.


We report here a case of cardiovascular and neurological depression induced by oxymetalzoline in a toddler.


ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.


Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically with no need for maintenance steroid therapy.


Terbinafine is given as continuous dosing, 250 mg per day for 3 months.


Carbamazepine was discontinued and the patient remained asymptomatic.


The prognosis of Mycobacterium avium complex (MAC) infection has been improved by new macrolides-containing regimens and the use of highly active antiretroviral therapy (HAART) in the treatment of acquired immunodeficiency syndrome (AIDS).


The patient revived 1 1/2 hours after treatment.


Long-term clinical outcome after accidental overdose of multiple chemotherapeutic agents.


Disseminated Aspergillus terreus infection arising from cutaneous inoculation treated with caspofungin.


A case of drug-induced hypersensitivity syndrome showing transient immunosuppression before viral reactivation during treatment for pemphigus foliaceus.


The first neurological symptoms like paraesthesia, severe hyperpathia of the legs and mild to heavy spinal ataxia occurred after an average time of treatment of 78 days and a mean dosage of 52 g.


Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.


Clonidine is being used increasingly for treatment of spasticity in patients with spinal cord injury.


A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy.


Paecilomyces lilacinus infection in a liver transplant patient: case report and review of the literature.


The dose was adjusted to 1 g every 12 hours during continuous venovenous hemodialysis.


A CT of the thorax revealed newly developed bilateral pulmonary ground-glass opacity corresponding to the previous radiation fields.


All had a muscle biopsy, but only one showed the classical rimmed vacuoles.


She was diagnosed as TOS by digital subtraction angiography.


Excessive use of salbutamol inhalers is described in two young people with asthma, a girl and a boy both aged 15 years.


In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.


Ethambutol toxicity manifesting as acute onset psychosis.


Following a reduction in the doses of these drugs, the symptoms and signs related to the superior sagittal sinus thrombosis gradually subsided, and the haematological pictures remained in remission.


We report in detail an unusual adverse reaction to infliximab therapy, a drug-induced lupus-like clinical syndrome.


The renal function of the baby was completely recovered, without systemic antifungal treatment.


Alteration of speech is a rare but distressing complication of orthotopic liver transplantation (OLT).


Thrombophilia in the face of endocarditis should be treated with a suspicion of underlying cancer.


Simvastatin therapy was resumed and resulted in a prompt and severe return of his symptoms.


The right time to perform surgery is hard to define.


Concentrations of brompheniramine and dextromethorphan were measured in both postmortem blood and liver specimens using a gas chromatograph equipped with a nitrogen-phosphorus detector.


Disulfiram-like reactions with newer cephalosporins: cefmenoxime.


A heparin-like effect was suspected.


The outcome was fatal in both patients.


In the presence of risk factors, such as cGVHD, prophylactic treatment for toxoplasmosis should be reinstituted; Trimethoprim-sulfamethoxasole most probably prevented earlier reactivation of toxoplasmosis in our patient.


After the correction of hyponatremia, due to the high liver enzyme levels, he was diagnosed as rhabdomyolysis.


Intraoperative anaphylaxis: verba volant, scripta manent!


Interferon (IFN) is the most widely prescribed drug of choice for chronic hepatitis B infection, which is a common health problem in our country.


Cyclosporin therapy in Mooren's ulcer.


The elimination half-time (15 h) was similar to that reported for end-stage renal disease patients, while the steady-state volume of distribution (85 l) and the area under the curve concentration (127 mg/l.h) were greater.


We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis.


METHODS: We report a patient with symptoms of small bowel obstruction whose diagnosis was confirmed by previous operation owing to a well-known pathology due to an unusual reason, perforation, which was masqueraded by therapeutic drugs.


We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).


A 6-month-old girl was treated with FK506 after undergoing living donor liver transplantation for fulminant hepatitis.


The role played by repeated drug prescriptions from general practitioners without appropriate clinical and laboratory controls, and that of our patient's depression are discussed.


CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.


Hemorrhagic myocardial infarction complicated by free wall-rupture: a case associated with unusual clinical features following intravenous thrombolytic therapy.


DISCUSSION: The pathogenesis of fixed drug eruption and the role of MIF assay in the diagnosis of adverse drug reaction is discussed.


Complete removal of all foreign material is essential, however when prosthesis removal is not possible or contraindicated, suppressive antibiotic therapy with retention of the functioning hip arthroplasty may be considered.


Recurrent hyponatremia associated with citalopram and mirtazapine.


Lethargy in a newborn: lithium toxicity or lab error?


Management of upper gastrointestinal haemorrhage complicating dual anti-platelet therapy.


The episode lasted 1 week and was followed by a dramatic fall in plasma sodium (104 mEq I-1), associated with a proportionally lesser decrease in plasma chloride and phosphate.


It is concluded that hypoparathyroid patients being treated with vitamin D and calcium should be carefully monitored in the case of an intercurrent illness or a change in medication.


Once benefit occurred, we discontinued or reduced other anticataplectic medication.


He had hypokalemia (K 2.3 mmol/L) induced by licorice and also had received disopyramide for arrhythmia, bicalutamide for prostate cancer, and silodosin for prostate hypertrophy.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


We have used anti-angiogenetic therapy with thalidomide in two AILD patients and observed remarkable responses.


A 54-year-old man with polyarteritis nodosa developed acute onset of right upper quadrant abdominal pain associated with a large liver mass.


BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.


Central venous catheter (CVC)-related infections were most frequent (n = 20) followed by otitis externa (n = 6) and pneumonia (n = 5).


Three of the 4 patients with hydrocephalus secondary to CNS tumor suffered secondary shunt complications during periods of severe neutropenia resulting from chemotherapy (6 weeks to 6 months after shunt insertion).


RESULTS: Delay in clinical recognition and treatment in our first case resulted in death due to multiorgan failure (MOF).


With this therapy the clinical manifestations of Reiter's Syndrome disappeared but sudden abdominal and bronchopulmonary symptoms complicated the picture and the patient died in a septical shock.


Xanthomonas maltophilia endophthalmitis after cataract extraction.


Therefore, the critical care nurse must have knowledge of the implications of administering standard antiarrhythmic agents if this patient reverts into a tachyarrhythmia.


Subsequent studies have not shown convincing evidence for a strong association with beta-blocker use and depression.


Most reactions develop cutaneously.


The patient reported herein strengthens the association between the 22q11.2 deletion spectrum and Evans syndrome.


An increasing range of drugs have been reported to cause sAML, including the alkylating agents, the epipodophyllotoxins and the anthracyclines, both as single agents and in combination (Pedersen-Bjergaard & Philip, 1991; Pedersen-Bjergaard & Rowley, 1994).


Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.


A case of disseminated Aspergillus terreus infection in a patient with prolonged neutropenia after stem cell transplant for myeloma is reported.


Dipyridamole stress testing may be used in the diagnosis of coronary artery disease and risk assessment of patients who are unable to exercise.


The unusually though potentially life-threatening possibility of heart failure secondary to anti-TNF use in ankylosing spondylitis merits attention.


The causal relationship between the drug and the eruption has been based mainly on circumstantial evidence and is further strengthened by the positive result of one or two in vitro tests: the macrophage migration inhibition (MIF) test and the indirect rat mast cell degranulation (MCD) test.


He further reduced his dosage to 15 mg every morning on days 13 and 14 of varenicline therapy, and his supply of amphetamine-dextroamphetamine was depleted on day 15.


Gastrointestinal (GI) tract disease is an unusual presentation of this yeast infection.


Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.


Four subsequently did well on clozapine therapy.


Troglitazone-induced fulminant hepatic failure.


Treatment with an epidural blood patch (EBP) via the caudal approach resulted in complete relief of symptoms.


Strongyloides stercoralis infection is known to be important because of its potential for life-threatening disseminated infection in immunosuppressed hosts.


Treatment for her breast cancer had included surgery, radiation and chemotherapy with doxorubicin and cyclophosphamide.


He stated he was fit and well and denied taking any medications.


Cervical artery dissection (CAD) recurrences are rare but the risk could be higher during the first month.


Metformin was stopped.


Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.


A critical review of the treatment regimen and prophylaxis for C1-inhibitor deficiency is presented, and three new cases are described.


However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.


Both of the Campylobacter jejuni isolates were resistant to cotrimoxazole and ciprofloxacin.


Amiodarone-induced dysthyroidism.


After the third injection to the abdomen, the patient developed a rash, and after the fourth and fifth injections to other areas of the abdomen, injection-site papules were seen.


These arrhythmias were resistant to standard antiarrhythmic therapy.


This case series demonstrates that secondary open-angle glaucoma can be a sight-threatening consequence, and periorbital steroids should therefore be used cautiously and sparingly, particularly in those with a family history of glaucoma.


The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism.


Ritonavir can induce glucuronidation of several medications including ethinyl estradiol, levothyroxine, and lamotrigine.


In the two new cases, the causality assessment was judged as "possible" according to the RUCAM score.


Persistent segmental cutaneous anesthesia after a brown recluse spider bite.


The median follow-up exceeded 7 years and 72% of these patients had received prior alkylating agent therapy.


Symptoms cleared after drug withdrawal and repeated testing produced no claudication.


Other upper tract neoplasms after cyclophosphamide are reviewed.


We report a third case of a 6-week-old infant with Escherichia coli sepsis who received ampicillin and other antibiotics and subsequently developed TEN.


Pustular psoriasis-like tinea incognito due to Trichophyton rubrum.


Sporadic rippling muscle disease unmasked by simvastatin.


Aortic thrombosis resolved with enoxaparin in a patient treated with cisplatin-based regimen for small cell lung cancer.


Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.


BACKGROUND: Etanercept is a tumor necrosis factor (TNF) inhibitor that has been licensed in the United States for the treatment of adult and juvenile rheumatoid arthritis as well as psoriatic arthritis.


No woman was affected.


On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.


The patient failed to respond to treatment with a conventional dosage of a lipid formulation of amphotericin B (lifoAmB; 5 mg/kg/day) given alone or in combination with itraconazole, and he responded only to an aggressive strategy that included a very high dosage of lifoAmB (15 mg/kg/day) given in combination with itraconazole as well as a rapid reduction in immunosuppression.


The trachea was immediately intubated and the lungs ventilated with oxygen 40% for four hours.


He is known to have had epilepsy since childhood.


Hypersensitivity to the drug has not been reported.


Three cases of gold-related neuropathy are reported.


Five days of treatment with ketoconazole alone was ineffective in our patient's infection.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


Pericarditis and cardiac arrhythmias developed, but the patient did not have cardiac tamponade.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Lithium serum level was within the therapeutic range.


Further studies are needed to determine the optimal dose and schedule of DMSO application and to assess its efficacy in extravasation injuries from other vesicants.


However, we did not know of the previous tragedies nor had we fully understood how critical examination of some of our own earlier near misses could have made such a tragic mistake less likely to occur.


We present two such case of epilepsy induced by video game.


Because high AUCs of 4-hydroxycyclophosphamide, thiotepa/tepa and carboplatin correlate with increased toxicity, the treatment risk in this obese patient was significantly increased.


Coronary vasospasm resulting from a sudden autonomic response associated with an intracranial procedure was encountered during percutaneous radiofrequency trigeminal rhizotomy.


Accidental intrathecal injection of the wrong drug was suspected and a used ampule of tranexamic acid discovered in the trash can.


This has rarely been reported before in the literature.


Capecitabine-induced headache responding to diltiazem.


After treatment with dose-intensive intravenous melphalan followed by infusion of autologous growth-factor-mobilized blood stem cells, clinical evaluations and plasma cell studies were repeated at 3 and 12 months.


We report a 40-year-old man who presented with acute onset of hemophagocytic syndrome (HPS) after allogeneic bone marrow transplantation (alloBMT) for acute myelogenous leukemia.


Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors.


A lumbar myelography was carried out, and a dorsal block was demonstrated.


Stent fracture: an unusual cause of late restenosis after sirolimus-eluting stent placement.


A few round Russell bodies were seen in the first biopsy specimen and none in the third.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


A case report.


We report the case of a 20-year-old female with polyarteritis nodosa (PAN) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac.


A diagnosis of sarcoidosis was determined from a lung biopsy.


Intrapericardial infusion of 5-fluorouracil.


Augmentation, defined as a loss of circadian recurrence with progressively earlier daily onset and increase in the duration, intensity, and anatomy of symptoms, not compatible with the half-life of the drug, is associated with dopaminergic treatment in restless legs syndrome (RLS) patients.


An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


We recommend strict monitoring of serum antiepileptic drug (AED) levels to avoid toxicity and inadequate seizure control.


This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.


The symptoms disappeared when desipramine was discontinued and in one case returned when desipramine treatment was reinitiated.


The thrombus causing the liver infarction was detected as a low echoic mass by transesophageal echocardiography at the right coronary sinus.


Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.


The patient remains free of arrhythmia 15 months after the event with the combination of propranolol and amiodarone.


Sodium phenylbutyrate was added to treatment with HU in two patients, but failed to produce an increase in total Hb despite increasing Hb F levels.


Chemotherapy related fatal neurotoxicity during induction in acute lymphoblastic leukemia.


We report a case of Sweet's syndrome in association with sargramostim treatment following chemotherapy for acute myelogenous leukemia.


Topical hydroquinone is used in the treatment of a number of skin conditions.


Previously reported cases of persistent proximal right umbilical vein have shown a variety of other malformations but a single umbilical artery has been the most consistent.


Russell bodies in contact-lens-associated giant papillary conjunctivitis.


No sedative or anxiolytic effect comparable to minor or major tranquilizers could be observed.


Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.


Thrombosed prosthetic valve in tricuspid position.


The AVM was embolized without incident, however, the AVF was not accessible.


Stopping further solvent exposure failed to improve his condition.


We observed 5 reactions in 3 patients that appear to be related to a high dose-infusion time ratio, indicating that dose and rate of infusion may be important factors in precipitating anaphylactoid reactions with cisplatin.


CASE SUMMARY: TLS developed in 2 neonates born at 38 weeks' gestational age; both were managed in part with rasburicase.


OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.


Systemic drug toxicity is unusual when FUdR is given via HAI, and neurologic toxicity has not previously been reported.


Despite these changes, the sensitivity of the mutant virus to zanamivir assessed by a standard test in MDCK cells was unaffected.


All three patients experienced remission of their disease at the time of the occurrence of marrow aplasia.


The literature is reviewed and the treatment implications are discussed.


Intestinal wall thickness, evaluated by ultrasound, is an important prognostic factor which could act as a guide to surgical indication.


2. The plasma cortisol level was significantly higher in the low-dose period (mean 13.90 +/- 3.35 micrograms/ml) than in the high-dose period (mean 9.06 +/- 2.75 micrograms/ml) although, paradoxically, the panic attack frequency was significantly lower in the low-dose period (mean 1.35 +/- 0.29/day) than in the high-dose period (mean 2.09 +/- 0.66/day).


Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.


Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.


Current antiamoebal therapy was effective and regrafting in the quiet eye was successful.


We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.


In the absence of other causes, we suspected an adverse reaction to amiodarone, not least because of the similarity with histologic findings of cases previously reported.


Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.


These changes, in combination with care providers' fear of opioids, often lead to the inappropriate use of antagonists, such as naloxone.


Pelvic arterial pseudoaneurysm is generally treated by laparotomy and hemostatic sutures or by uterine artery embolization.


Some degree of biochemical improvement was also noted in the other cases in whom the blood lactate levels before treatment were 15, 17, and 31 mM.


During treatment with alefacept, the patient's psoriasis improved markedly without exacerbation of his photosensitive SCLE lesions.


PATIENTS AND METHODS: Progressive renal dysfunction developed in two adolescent black girls with high-risk ALL who underwent renal biopsies that were consistent with FSGS.


Histologic assessment of pleural fluid revealed no malignancy and results of video-assisted thoracoscopic surgery were normal.


Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.


On days 2-6, the patient experienced a myocardial infarction, ischemic cerebrovascular accident, recurrent lower extremity arterial thrombus, and splenic infarct.


Injury to the spinal cord injury with paraplegia, is a rare complication of surgical repair of aortic coarctation recognized immediately post-operatively.


A skeletal X-ray showed huge amounts of periarticular TC.


CONCLUSIONS: This case illuminates a possible role of UV therapy in the induction of pemphigus herpetiformis through an epitope-spreading mechanism.


We report a case of pulmonary toxoplasmosis after heart transplant despite the prophylactic anti-toxoplasmic treatment that was given but was not sufficient to prevent toxoplasmosis.


Following repair of the graft override on postoperative day 42, the epithelial defect healed.


Subsequent testing revealed that this patient has an extremely low level of DPD activity (0.015 nmol/min/mg protein; mean, 0.189 nmol/min/mg protein).


Acute myelogenous leukemia following treatment of invasive cervix carcinoma: a case report and a review of the literature.


SUBSEQUENT COURSE: The nephrosis resolved almost completely once the interferon was stopped and after immunosuppressive treatment.


Thrombosis, leiomyoma and GnRH-a therapy.


Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients.


RESULTS: A 69-year-old Saudi man underwent penetrating keratoplasty with donor tissue that was culture-positive for Candida glabrata.


CASE DESCRIPTION: A 21-year-old male was initially evaluated because of a large mass that had been growing for 7 months.


Our patient, diagnosed with persistent ovarian carcinoma, had a peritoneal Tenckoff catheter placed for chemotherapy.


RESULTS: The patients in our series improved significantly when the serotonin antagonist cyproheptadine was added to their regimens.


The only adverse effect was seroconversion of anti-hepatitis C virus after receiving 108 bottles of LC for 36 weeks.


The currently reported cases are the first observed clinical activity of a kinase inhibitor against the T315I phenotype.


Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.


Histological and immunohistochemical studies of paraffin embedded specimen were conducted.


Tiagabine (Gabitril) is a unique anticonvulsant that is prescribed for a variety of psychiatric disorders.


Bronchospasm did not recur, making it unlikely that tartrazine hypersensitivity caused this problem.


Fluorescein angiogram showed presence of venous collaterals, but the pattern of the edema was atypical; optical coherence tomography (OCT) and indocyanine green angiography (ICG) were used to confirm the diagnosis of CNV.


Intraperitoneal chromic phosphate is widely used as adjuvant therapy in the treatment of early-stage ovarian epithelial carcinoma.


A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.


This patient was treated successfully by surgical excision of the affected segment of ileum together with intravenous ganciclovir.


He sustained a myocardial infarction on postoperative day 7 and progressively deteriorated and expired five days later.


Until the mechanism of the formation of rickets in small premature infants is clarified it is recommended that supplemental calcium and vitamin D be given to all premature infants receiving parenteral nutrition, and that periodic x-rays be obtained to detect the development of rickets.


We describe a case of EGE manifested as an allergy to gemfibrozil.


We present a case report of a patient with typhoid fever who experienced a hypersensitivity reaction subsequent to the infusion of chloramphenicol sodium succinate.


Both patients were successfully treated with propylthiouracil (PTU) and dexamethasone (DXT).


Biochemical, bacteriological and imaging studies were performed for specific diagnosis.


The predisposing factors for toxicity are hypoalbuminemia, chronic renal failure, hepatic dysfunction and drugs which interfere with phenytoin metabolism.


Signs of severe liver disease included elevated aminotransferases, conjugated hyperbilirubinemia, significant coagulopathy, hepatosplenomegaly and ascites.


Mental illness in mild PKU responds to biopterin.


The presence of diabetes constitutes a cluster of particularly high cardiovascular risks in patients, both regarding diabetic damage and hypertensive damage.


Dental treatment is rarely associated with such an event.


She was admitted for observation and all symptoms resolved within 12 h of admission.


Severe microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment were each noted in about 90% of the cases.


Animal studies are necessary to evaluate this observation and potential disadvantages of hydrocortisone usage.


It has been demonstrated that bisphosphonate-based supportive therapy (pamidronate or zoledronate) reduces skeletal events (onset or progression of osteolytic lesions) both in patients with multiple myeloma (MM) and in cancer patients with bone metastasis.


METHODS: Review of medical records for 4 patients presenting retinochoroiditis and evidence of T. gondii infection.


RESULTS: The estimated number of Accutane prescriptions for reproductive-aged women has more than doubled in the past 10 years; it is the most widely used teratogenic drug in the United States, with approximately 2.5 per 1,000 reproductive-aged women exposed to Accutane in 1999.


CONCLUSIONS: This novel chemotherapy regimen achieved favorable results and may be useful in treating patients with unresectable multifocal HCC resistant to TAE.


They also demonstrate the possibility of durable complete remission of post-ASCT PTLD following antiviral and immune modulating therapy.


CONCLUSION: Significant weight loss is a potential adverse event in patients with rheumatoid arthritis treated with leflunomide.


METHODS: Four white female infants with sight-threatening periocular hemangiomata received a combination of steroid injections of triamcinolone and betamethasone.


Sustained and nonsustained ventricular tachycardia: genesis, significance, and management.


Recent evidence also suggests that these same medications enhance the patient's response to acute migraine therapies, and may also reduce the likelihood of developing chronic daily headache.


CT scan of muscles showed similar cysticerci producing a 'honeycomb' appearance.


Her platelet counts were never less than 75% of baseline and were consistently above 200 x 10(3)/mm(3).


Hepatoxicity is a rare complication of SRL therapy and may be connected with some diagnostic and/or therapeutic problems.


Earlier reports documented similar symptoms in patients without a history of heart failure.


The pathophysiological mechanisms remain unknown, although the drug could act through massive cytokines liberation after destruction of CD20 positive cells by rituximab.


Celiac disease diagnosis was performed and symptoms and laboratory abnormalities improved after gluten-free diet.


Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.


The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.


A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked.


These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent.


Lumbar spinal cord stimulation for cervical-originated central pain: a case report.


Repeat standardized neurodevelopmental assessments (Peabody and Griffith scales) at 13 and 19 months were normal and magnetic resonance spectra no longer detected the previously observed lipid resonance.


Commonly, opioid drugs are administered in patients with acute cholecystitis to relieve pain.


Even if an oral multivitamin preparation is given instead of MVI, patients with malabsorption may not absorb thiamine adequately.


An unusual response to progestin therapy of hyperplasia.


Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.


DESIGN: Case report.


16 patients with cutaneous or subcutaneous melanoma recurrence on an extremity were treated with regional perfusion with Melphalan.


We believe that methotrexate represents a relatively effective alternative to surgery in patients with early unruptured tubal pregnancy, but suggest that it be used with caution in view of possible systemic toxicity.


Ciclosporin was effective at controlling all symptoms of SNHL.


Then, she told, the slight pain and the reddened area which developed around the injection site disappeared completely and he turned back to his daily activities.


Visceral leishmaniasis is rare among patients under immunosuppressive therapies, and even more among patients under anti-TNF-alpha treatment, where only four cases have been described.


Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin.


The mechanisms and occurrence of lymphoma after immune response modifiers are discussed.


Pancreatic enzymes were discontinued, and she was given a low-fat, high-carbohydrate diet with satisfactory weight gain.


CASE PRESENTATION: A 46-year-old man consulted his doctor due to symptoms of depression.


METHOD: Onset, course, and outcome of the patient's eye disease were analyzed.


Review of the literature showed similar occurrences in other patients.


The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.


A causal relationship is strongly suggested by the mode of onset, the absence of a previous history of catatonia, and the rapid resolution of the syndrome within 72 hours of discontinuance of the disulfiram therapy.


In vivo confocal microscopy showed swollen and enlarged cellular structures and the presence of microlacunae separating the stromal collagen lamellae.


The patient was a nonsmoker with no respiratory illnesses.


Yoga neuropathy.


We describe the case of an 82 year old woman developing severe respiratory functional impairment after open heart surgery and subsequent surgical pericardial drainage inducing diaphragmatic spasm and successfully treated with gabapentin.


Perioperative records were reviewed for use of topical 1:1000 epinephrine and for any intraoperative or postoperative complications related to its use.


The doses were 3,000, 6,000, or 12,000 U/day.


Rupture of the plantar fascia in athletes engaged in sports that require running and jumping has been reported.


Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma.


This patient was treated with endovascular stenting of the dissections along with cessation of ergot.


RESULTS: Despite treatment with various neuroleptics, the psychosis resolved only when the interferon/ribavirin were discontinued.


Within six hours the patient had a partial relapse which resolved completely following further intravenous dantrolene 2 mg/kg.


We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.


Hydroxyzine alone caused an insignificant delay.


Evidence-based mental health use of anticonvulsants during pregnancy.


A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.


Topical corticosteroids used for dermatological conditions around the face and eyes are often regarded as being fairly innocuous with regard to ocular side-effects.


Pentamidine is one of two agents currently used to treat infections with Pneumocystis carinii.


The history of desmopressin use was still not available.


Ten hours after the second methotrexate injection, the patient experienced a diffuse pruritic papular eruption located mainly on the limbs.


Caspofungin, a beta-1,3-glucan synthesis inhibitor, has shown activity against the cyst forms of P. jiroveci in experimental animal models.


Physicians must consider this when prescribing these medications for patients with misdirected eyelashes.


In addition, immunohistochemical findings of a dense CD8+, TIA1+ and granzyme B+ lymphoid infiltrate within a biopsied lesion provide indirect evidence of functional T-cell activation induced by treatment.


Severe Raynaud's phenomenon with yohimbine therapy for erectile dysfunction.


Drug-induced gingival hyperplasia is well documented within the literature.


A crusty cause of prosthetic valve endocarditis.


We report the case of a 13-year-old boy who was known to have Fanconi's anemia for five years.


No invasive vascular procedure had been performed.


Methylphenidate (Ritalin)-associated cataract and glaucoma.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Hypocomplementemia and transient evidence of vasculitis suggested the presence of immunecomplexes.


In each case, some degree of recovery followed discontinuation of the statin medication.


The asthma resolved within 24 hours following three albuterol inhalations.


Early clinical suspicion and availability of CT or magnetic resonance imaging for prompt diagnosis are essential to initiate appropriate medical therapy and timely surgery.


We present three prednisolone-treated boys with myoglobinuria and in two cases this was recurrent.


Treatment of ELP in children is generally supportive, with the symptoms and roentgenographic abnormalities resolving within months after stopping the use of mineral oil.


A 25-year-old woman with rheumatoid arthritis for the past 5 years started to develop gradual enlargement of her breasts 15 months before presentation.


The new drug had been added to the long-standing treatment with risperidone.


In patients with chronic heart failure, spironolactone added to conventional treatment may lead to serious and, occasionally, fatal hyperkalaemia.


Examination revealed a fully conscious patient with slight dyspnoea and mild wheezing which responded to oxygen 30% and nebulised bronchodilators.


Unusual late pulmonary complication in a child after umbilical cord blood transplantation: high-resolution CT-pathologic correlation.


CASE: A 71-year-old man without immunodeficiency developed corneal endotheliitis in the right eye.


CASE SUMMARY: We report a case of a 73-year-old postmenopausal woman with stage T2N0M0 breast cancer.


There was neither a recurrence of cytomegalovirus retinitis nor an occurrence of retinal detachment during the 9-month follow-up after intravenous ganciclovir therapy.


As more women of childbearing age are being identified as HIV infected, vertical transmission to the fetus and/or neonate is an increasingly significant therapeutic problem.


However, we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function.


Organisms that may be associated with an enteric source should prompt a thorough gastrointestinal evaluation.


Giant cell lichenoid dermatitis is a recently described pathological entity, which can be seen as an unusual lichenoid drug eruption, a manifestation of sarcoidosis or within herpes zoster scars.


Single photon emission computed tomography (SPECT) revealed a low density of presynaptic dopamine transporters in our patient's brain.


All cases were diagnosed with Acanthamoeba castellanii by culture on nonnutrient agar, corneal scraping, and/or confocal microscopy.


Many augmentation strategies have been tried in the past with varying levels of success or safety.


The symptoms and biochemical abnormality improved after gradual discontinuation of carbamazepine.


A 47-year-old woman with a history of breast cancer presented with eruptive cutaneous nodules on the trunk and extremities.


Significant dose reduction was possible in all three without loss of asthma control, emphasising the importance of back-titration to minimise dose.


On this mechanistic basis, we treated three consecutive patients with metastatic PEComa with an oral mTOR inhibitor, sirolimus.


Case report: lack of control of diabetes and weight gain in a patient on initiation and rechallenge of therapy with olanzapine.


The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.


Quinine-induced hearing loss.


PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.


"B" was an 11-year-old girl with mild mental retardation and aggression who was treated with risperidone 1 mg per day.


The pathophysiology for this unusual disorder may be agonist-induced dopamine receptor hypersensitivity.


The patient tolerated the chemotherapy well and did not develop any skin or nail changes during that period of time.


Unfortunately, the access device frequently provides a foci for debilitating infections.


Corticosteroids should be used in low doses and with great caution in scleroderma patients.


INFVA was screened in NPA and/or bronchoalveolar lavage using IF in all BMT recipients having respiratory symptoms.


This patient had no evidence of previous neurologic disease.


Her primary care physician had earlier made a preliminary diagnosis of pertussis and prescribed a short course of azithromycin and corticosteroids, which did not help relieve the symptoms.


A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.


Quetiapine-induced myoclonus.


In our two patients, we investigated NAT2* genotypes by the polymerase chain reaction-restriction fragment length polymorphism method.


She had received seven courses of chemotherapy, with a cumulative doxorubicin dose of 500 mg/m(2) over 5 months, resulting in minimal tumor regression.


As the child's adoptive parents controlled medication access, they were investigated by social welfare agencies.


Median time to progression (TTP) was 12 weeks.


Apart from this, the patient also showed clinical signs of obstructive sleep apnea syndrome that was confirmed by polysomnographic study.


Twenty-six patients with mycosis fungoides were treated topically with three nitrosourea compounds: carmustine (BCNU), lomustine (CCNU), and 1-methyl-1-nitrosourea.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


Each case (stage IB and IA) occurred after initiation of the subcutaneous anti-tumor necrosis factor medications etanercept and adalimumab, respectively.


The addition of intrathecal methotrexate to treatment protocols has increased survival rates in children with acute lymphoblastic leukemia but is also associated with varying degrees of neurotoxicity.


Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.


The patients were not experiencing rebound phenomena at the onset of treatment with naratriptan.


Drug induced myopathies have been implicated with the use of several medications.


A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.


The right eye was regrafted three months after the recurrence and penetrating keratoplasty was done two years later in the left eye.


We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.


Use of the Naranjo probability scale determined the association between cephalosporin use and leukopenia to be probable.


Our data suggest that low-molecular-weight heparin possesses strong renoprotective properties, thus confirming previous data from experimental nephropathies.


Both patients manifested other symptoms consistent with parkinsonian syndrome.


Four of the 14 women did not have pregnancy tests before starting Accutane.


CASE SUMMARY: A 42-year-old African American woman with metastatic breast cancer developed progressive disease.


Only 13 SLE patients with AMI caused by coronary artery aneurysms have been reported, 11 of whom were young or middle-aged women and the 2 remaining were young men.


In two patients in whom conventional therapy failed, clotrimazole was successful in controlling recurrent infection following penetrating keratoplasty.


OBJECTIVE: To report the case of a patient with a prior allergy to a sulfonamide antibiotic who subsequently developed the same reaction when administered various loop diuretics.


In conclusion, the present case report illustrates a novel manifestation of chronic granulomatous disease.


The Karnofsky score calculated in 29 patients showed improvement in all patients except those aged greater than 70 years.


Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura.


Liposomal amphotericin B was prescribed at the standard dose of 5 mg/kg/day; however, amphotericin B deoxycholate 5 mg/kg was inadvertently administered (usual dose of the deoxycholate formulation is 0.5-0.8 mg/kg/day).


Oral adverse effects due to the use of Nevirapine.


Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.


The blocked catheter was surgically explanted and the firm material inside was analyzed.


Lymphoma usually responds well to multiagent chemotherapy.


Human insulin-induced lipoatrophy.


Recent studies have found clozapine a highly effective and ECT a possibly useful intervention.


All 3 marrow specimens demonstrated moderate to marked diffuse reticulin fibrosis with more than 20% blasts.


A 10-year-old boy was diagnosed with ADHD and had received methylphenidate hydrochloride, 60 mg/day for 2 years.


Stanozolol was well tolerated and had minimal side effects.


Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.


An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.


We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.


Fixed drug eruption of the scrotum due to methylphenidate.


Strong expressions of PDGF-B and IGF-1 on alveolar macrophages and type II pneumocytes were clearly demonstrated, but in contrast, the expressions of TGF-beta1 and COX-2 were almost undetectable.


Clostridium difficile colitis associated with cisplatin-based chemotherapy in ovarian cancer patients.


The child died 62 days after discontinuation of prostaglandin treatment.


Dosing in these patients requires very careful management.


On examination, rigors, shallow inspirations, and chills were noted.


Photochemotherapy using psoralen and ultraviolet (UV)A irradiation (PUVA) is a useful treatment method for vitiligo.


In addition, gabapentin treatment enhanced the frequency of hypothermic episodes in a separate patient with known hypothalamic dysfunction.


Heart rate, blood pressure, nausea ratings, and the occurrence of emesis were recorded during 18 chemotherapy treatments over a 9 month period.


Gradually, her immune status and ocular symptoms improved.


BACKGROUND: Opioid based cough mixtures are readily available to the public and are generally used safely.


His inhibitor was increased from 15 to 580 BU within the first 4 weeks of immune tolerance.


After appropriate antibiotic and replacement of the central venous line, CT demonstrated disappearance of the lung nodules in all three patients, enabling a diagnosis of nodular septic embolism.


Esophageal candidiasis following omeprazole therapy: a report of two cases.


General practitioners frequently find themselves caught between the desire to treat and relieve symptoms, and not wanting to cause or exacerbate dependence.


OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.


Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.


During the course of treatment, photosensitisation by clofazimine led to a dermatological disease resembling actinic dermatitis.


Administration of an angiotensin II receptor antagonist (ARB) during the second trimester of pregnancy is known to cause irreversible renal damage in the fetus.


Methotrexate inhibits the enzyme dihydrofolate reductase and prevents the formation of DNA and RNA.


In the present paper, we report on two siblings with G6PD deficiency who developed haemolytic anaemia following topical application of henna to their whole body to treat skin lesions.


Secondary leukemia with a translocation (8;21)?


When the trazodone was reduced, the involuntary movements promptly ceased.


We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).


Human immunodeficiency virus type 1 (HIV-1) p24 antigen was detected at the beginning of 5 of the 6 treatment courses.


Ototoxicity was assumed, but the deficit was later found to be of a conductive nature, due to marrow proliferation within the ossicular chain as a consequence of the disease process--a phenomenon previously unreported in the literature.


Cerebral hemorrhage from amyloid angiopathy and coronary thrombolysis.


Acute renal failure required dialysis but with subsequent recovery.


These syndromes are often undiagnosed or misdiagnosed and lead to unnecessary morbidity and noncompliance with recommended pharmacotherapy.


Cholesterol-lowering agents have been demonstrated to decrease hepatic lipids in Niemann-Pick type C patients.


A case of mania associated with fluoxetine.


The immunoassay's known cross-reactivity for carbamazepine is reportedly as low as 0.3%.


Both procedures were uncomplicated until about 30 min after reperfusion of the graft, when the cut surfaces began to ooze blood.


We will also discuss the clinical and pathophysiological considerations.


DISCUSSION: Electrolyte disorders associated with foscarnet are reviewed.


CONCLUSION: Close monitoring for severe skin reactions is in order when using leflunomide.


These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.


We describe the case of a 61-year-old Peruvian man, who received bilateral lung transplants for idiopathic pulmonary fibrosis, and subsequently developed persistent fever with pulmonary infiltrates, ventilator dependence, and pneumothoraces.


We describe an 11-year-old girl who presented with widespread erythematous and pustular lesions being treated with topical corticosteroid.


The six patients who received mecamylamine only also significantly improved (Wilcoxon signed rank test, p < 0.2).


We report three cases of patients who developed leukopenia during olanzapine treatment.


Arthritis and bursitis in multiple sclerosis patients treated with interferon-beta.


Primary Central Nervous System Lymphoma (PCNSL) was seen in 2% of the liver, and 2% of the heart recipients.


Pulses were administered after the injection of 1% lidocaine solution around the treatment site.


Acute pleuropericarditis relevant to post-cardiac injury syndrome with an atypically early onset might have occurred in this case as a rare complication of PCI.


From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).


There was no loss of consciousness.


We report a case of chronic use of HCQ associated with torsade de pointes.


Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.


Hematocrit was 20% (previously 33%).


It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.


In each patient, a different method successfully removed the touch of the anterior vitreous face to the corneal endothelium with subsequent prompt clearing of the corneal edema.


The concern about depression associated with beta-blocker use grew out of one widely referenced case report.


This case reveals that HPS could develop after alloBMT, even when engraftment of hematopoietic cells is not confirmed.


In addition, known and/or possible mechanisms of the disorders are discussed.


Six children with refractory acute lymphocytic leukemia were treated with vincristine combined with diltiazem.


The immunosuppressive regimen consisted of tacrolimus, mycophenolate mofetil, and prednisone.


PURPOSE: To evaluate the toxicity of 1 mg of intraocular rituximab and to present a small case-series of patients treated with intravitreal rituximab.


Post-transplant EBV-related lymphoproliferative disorder complicating umbilical cord blood transplantation in patients of adrenoleukodystrophy.


We hypothesized that VVR induced inflammation and adversely affected mucociliary function, and tested this hypothesis in an animal model of airway inflammation.


Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.


Toxic optic neuropathy associated with ethambutol: implications for current therapy.


Median survival ranges from 15 to 24 months, and it appears that the disease cannot be cured.


We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.


Administration of lamotrigine, especially in combination with valproic acid, may lead to the development of TEN.


We discuss the association between carbamazepine and hyponatremia and the causes of hyponatremia after cardiopulmonary bypass.


Linear immunoglobulin A bullous dermatosis induced by gemcitabine.


CONCLUSIONS: We conclude that a high dose combined with a short infusion time increases the risk of anaphylactoid reactions with the administration of intraperitoneal cisplatin.


Catheter occlusion by calcium carbonate during simultaneous infusion of 5-FU and calcium folinate.


RESULTS: A single intravitreal injection of triamcinolone induced clinical and angiographic resolution of inflammatory macular oedema in all patients for varying periods of time up to 6 months.


Astute observation, leading to the early detection of behavioral changes, may help avert the development of a costly and disabling complication of drug therapy.


Despite drug withdrawal there was evidence of persistent airways obstruction and bronchial hyperreactivity.


Nonfatal prolonged overdosage of pyrimethamine in an infant: measurement of plasma and urine levels using HPLC with diode-array detection.


Unlike most reported cases in which vertebral compromise rarely extends to more than two adjacent vertebrae, our patient had extensive compromise of the thoracic spine.


Radiation recall with oxaliplatin: report of a case and a review of the literature.


The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).


The patient subsequently developed progressive worsening of her vision and presented to our ED with bilateral visual loss.


Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.


Lithium has been reported to raise serum calcium and lower serum phosphate concentrations and to increase urinary calcium excretion.


Corticosteroid therapy is a rare but possible independent predisposition to PCP.


Sertraline 50 mg/day was again prescribed for the patient's persistent depressed mood.


This is a transient febrile illness that can occur in patients after the first adequate dose of an anti-microbial drug to treat infectious diseases such as syphilis, Lyme disease and relapsing fever.


Toxic streptococcal syndrome.


Stupor and fast activity have been related to the effects on gamma-aminobutyric acid type A (GABA(A)) receptors mediated by endozepines or by exogenous drugs such as benzodiazepines or barbiturates.


The primary outcome (behavioural disturbances) was measured prospectively by the Neuropsychiatric Inventory (NPI), while other outcomes included cognition (Mini-Mental State Examination (MMSE)) and Clinical Global Impression.


In this study, we report on three individual patients who received BTX-B and who subsequently developed parasympathetic dysfunction of the visual system after injections of BTX-B at remote sites.


In all three patients the bleeding stopped after a course of aminocaproic acid was begun.


Antisocial behaviour was controlled in 12 out of the 13 behaviour-disordered group.


These findings suggest that GL might inhibit HIV-1 replication in vivo.


An extraordinarily rare case report of mixed fat redistribution syndrome associated with osteopenia but not with relevant metabolic abnormalities is documented in a prepubertal child with congenital HIV infection treated with antiretroviral therapy since the age of six months, up to the present age of 12 years and two months.


A male patient with malignant lymphoma and thyroid papillary carcinoma after pediatric renal transplantation.


Minoxidil is a potent antihypertensive agent used in the treatment of resistant hypertension.


METHODS: Case series.


A short review on imatinib-related hepatotoxicity is also presented.


A combination of these two approaches may provide the best chance of improving outcome in severe acute ischemic stroke.


We report a case of a 64-year-old man with secondary adrenocortical insufficiency who has been on a chronic transdermal fentanyl treatment because of sciatic pain syndrome.


Visual hallucinations after intravitreal injection of bevacizumab in vascular age-related macular degeneration.


Systemic disease, most commonly renal dysfunction, preceded all 30 reported cases of acyclovir neurotoxicity.


CONCLUSION: Sexual side effects of fluoxetine may be more variable than previously thought.


Blood transfusions worsen the evolution of this peculiar form of HUS.


Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.


Prior surgical ligation of the peribiliary arteries around the extrahepatic bile duct followed by TAE was considered to have played a crucial role in the development of ischemic cholangitis.


This case study is the second report of localized purpura after prolonged lamotrigine treatment suggesting this may be an atypical lamotrigine-induced drug reaction.


A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.


We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.


Pigmentary aberrations are well known side effects of cytostatic chemotherapeutic agents.


However, none were as severe as the first rash.


Maintenance tricyclic antidepressants induced rapid cycling between mania and depression in five female bipolar (manic-depressive) patients.


A 65-year-old woman, in the intensive care unit because of septic shock and acute renal failure, had a small-bowel obstruction due to Amphojel concretions.


Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.


Respiratory function tests were useful in the diagnosis of the interstitial abnormality and in monitoring response to prednisone.


Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).


The reappearance of more virulent strains of exotoxin-producing streptococci over the past decade has led to the re-emergence of invasive Group A streptococcal infections and the recognition of a new syndrome resembling staphylococcal toxic shock syndrome.


Despite aggressive, combined antiviral treatment with ganciclovir and foscarnet and reduction of immunosuppression, viral clearance was never achieved.


It has only been described in 10 case reports since 1989.


Empirical therapy with antibiotics and conventional amphotericin B failed to resolve the infection.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


BACKGROUND: Infection continues to be one of the major complications of cerebro-spinal fluid shunting procedures.


A retrospective review revealed that the patient had been exposed to iopamidol, an intravenous contrast medium, on the day prior to the commencement of methotrexate treatment.


Metamizole use by Latino immigrants: a common and potentially harmful home remedy.


In the worst cases, these therapies are harmful.


Liver enzymes returned to normal 4 and 8 weeks, respectively, after riluzole withdrawal.


The cutaneous lesions resolved completely after 1 week of treatment with topical betamethasone dipropionate and gentamicin sulfate (twice daily).


The incidence of similar cases seems to increase.


Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN.


We propose diagnostic criteria for this under-recognized new clinical syndrome, and recommend that physicians routinely measure serum gastrin levels in persistent cases of PPI-dependent dyspepsia unassociated with H. pylori.


Case report.


Two months after the start of the therapy, parathyroid hormone (PTH) decreased significantly and the skin lesions nearly disappeared.


(2) Chemotherapy induced host tissue reaction has not been extensively studied.


We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.


We describe three testicular cancer patients who were cured with chemotherapy but developed bilateral osteonecrosis of the femoral head 17, 22 and 55 months after chemotherapy.


Knowledge of suspected cases will lead to early recognition and prompt management of this condition in the future.


They achieved a complete remission confirmed by light microscopy, but reverse transcriptase polymerase chain reaction remained positive after ATRA, underlining the need of further chemotherapy.


Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.


It is recommended that acid-fast stains be done on "diphtheroids" when such isolates are suspected pathogens.


The patient was then treated with IL-2 1.8 x 10(6) U/m2 for 5 days per week and 2.5 MU/m2 IFN-alpha three times per week.


Disseminated Nocardia asteroides and coinfection with Trichophyton rubrum in a renal transplant recipient.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


When the morning count of WBC began to fall, WBC count was repeated in the afternoons.


These infections may be life-threatening if appropriate therapy is not vigorously initiated.


Folinic acid rescue used routinely in psoriatic patients with known methotrexate "sensitivity".


A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.


Torsade de pointes occuring due to a long QT interval is a rare but potentially fatal arrhythmia.


An association is reported between Reye syndrome and varicella zoster virus (VZV) infection in a 10-year-old boy who had serologic evidence of coinfection with VZV and influenza A H3N2, and exposure to salicylates.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


These cases were considered unusual in light of the short delay of their onset after initiation of immunosuppressive therapy and their fulminant course: 3 of these patients died of PCP occurring during the first month of treatment with prednisone.


Clofazimine, previously used in the treatment of leprosy, is now used for treatment of Mycobacterium avium complex infection in patients with acquired immune deficiency syndrome, dermatologic disorders, and graft-versus-host disease.


This case seems to be one of the first descriptions of the clinical relevance of a CYP2D6 heterozygous genotype in a patient treated with antidepressant.


OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis.


We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease.


We report a case of medulloblastoma as a secondary malignancy in a patient treated for immature teratoma of the ovary (ITO).


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


At this point, she developed whole body urticaria and pruritus with edema of the extremities.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.


A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature, as well as possible alternative explanations in this case, are provided.


Thrombocytopenia, antithrombin deficiency and extensive thromboembolism in pregnancy: treatment with low-molecular-weight heparin.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


We studied the hypothalamic-pituitary-adrenocortical axis in two female patients before and during treatment with CPH82.


Listeria monocytogenes peritonitis in a patient on continuous ambulatory peritoneal dialysis.


During a second FAB infusion (400 mg) the patient reverted to regular AV-conduction.


We describe two cases of acute pancreatitis that occurred after long term mesalamine therapy for ulcerative colitis.


Generally, only a small proportion of prenatally exposed children are affected.


Five cases (four from the literature and one new case) are presented in which patients unsuspected of having vitamin B12 deficiency developed subacute combined degeneration of the spinal cord following nitrous oxide anesthesia.


By contrast, corticosteroids inhibited the LAR but not the immediate response.


The leucopenia and thrombocytopenia resolved on the 7th and 13th days of hospitalization, respectively.


The delusion occurred in an agitated hypomanic state and was preceded by an intense pruritus.


Molecular analysis confirmed the vaccine strain as the causative agent.


Acute coronary artery occlusion during percutaneous transluminal coronary angioplasty: reopening by intracoronary streptokinase before emergency coronary artery surgery to prevent myocardial infarction.


Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.


Pathology revealed the sarcoma adjacent to the recurrent ependymoma.


Two patients with giant atrial thrombi whose treatment involved complications are presented.


Acute tumour lysis syndrome in a dog with B-Cell multicentric lymphoma.


Neuroleptic malignant syndrome (NMS) is a potentially fatal adverse reaction to psychopharmacologic treatment.


Renal complications are uncommon and not well recognized.


To our knowledge, this is the first report of a bacterial corneal ulcer associated with use of a rigid gas-permeable contact lens on an extended-wear basis.


Eighty infants with proliferative retinopathy of prematurity (ROP) were treated with peripheral retinal cryoablation.


Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.


Case history of an African woman presenting with advanced HIV and a painful conjunctival lesion is presented.


He was hospitalized for 51 days and, after aggressive diuresis and discontinuation of pioglitazone, was discharged with a weight loss of 30 pounds.


Neuroimaging shows bilateral subcortical and cortical edema with prominent posterior distribution.


Headache, nausea, emesis, and lethargy were the presenting signs.


Eur J Paediatr Neurol 2002;6(3):153-9.].


CASE SUMMARY: A 61-year old man with a history of sick sinus syndrome with persistent atrial fibrillation and infrequent premature ventricular contractions was admitted to the hospital for symptoms of amnesia and disorientation to time, place, and date.


Dyspnea possibly associated with controlled-release morphine sulfate tablets.


The history is strongly suggestive of concurrent NMS.


He was initially treated with interferon alfa and subsequently relapsed within one year of treatment.


It has a considerably lower risk of cardiotoxicity than its parent compound, doxorubicin.


Quetiapine is a recently introduced atypical antipsychotic.


Carbamazepine is metabolized by this subsystem.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


The autopsy findings revealed massive Strongyloidiasis with the presence of larvae in several organs, particularly in the intestinal wall, the lungs and the liver.


Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.


METHODS: Case series consisting of 3 patients treated with rifabutin were retrospectively studied.


Diphenhydramine is generally considered an innocuous drug with a minimal risk for abuse and untoward side effects.


Various hypotheses as to the complex actions of morphine and its antagonist in epileptogenesis are discussed.


Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.


Each of these was subsequently reviewed by the hematologist who treated the patients for AML.


Blood gas analysis revealed a respiratory acidosis.


Compared with anthracyclines and taxanes, the interval from the completion of radiation therapy to the initiation of chemotherapy is less for gemcitabine (median time of 56 days for gemcitabine, compared with 218 days for the taxanes and 646 days for doxorubicin).


The suggested treatment algorithm allows for specific treatment of both disorders and avoids potentially exacerbating either one.


Scleritis complicating zoledronic acid infusion.


A case is reported in which treatment was given on postnatal day 3.


'Maqianzi' (the dried ripe seed of Strychnos nux-vomica L.) contains 1.0-1.4% each of strychnine and brucine.


Ampicillin may aggravate clinical and experimental myasthenia gravis.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


The median time to progression was 3.9 months and the median overall survival time was 11.6 months.


No relapse of pneumonia was observed after a 4-month follow-up.


There are no generally accepted therapeutic regimens for the treatment of fungal peritonitis in patients with continuous ambulatory peritoneal dialysis (CAPD).


A retrospective review incriminated transfusion therapy and volume overload as the etiology.


A severe form of Erythema multiforme (EM), diagnosed as Stevens-Johnson syndrome (SJS) was detected in a 10-year-old Indian male child who took herbal medication of plant origin prescribed by a traditional healer for remission of his fever.


However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.


Rational combinations of preventive medications may also be useful.


The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.


Fluoxetine-induced akathisia: clinical and theoretical implications.


Infection with Mycobacterium genavense in a patient with systemic lupus erythematosus.


Second, we report a case of neutropenia, which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide.


Priapism associated with zuclopenthixol.


Controlled studies are necessary to assess the efficacy, the duration of therapy required for effective results, and the safety of this treatment over the long-term.


A fifth child manifested clinical and radiographic signs of rickets after presenting with hypophosphatemia, hypouricemia, and glycosuria.


We suggest that sarcoidosis may develop in chronic hepatitis C patients during interferon alpha and/or ribavirin treatment, and diagnostic tests for this adverse effect should be performed during the follow-ups.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.


The possible deleterious effects of praziquantel therapy should be considered in the treatment of patients with subarachnoid cysticerci.


Here we reported the case of a liver transplant recipient with de novo HBV infection who had a favorable outcome after lamivudine (LAM) and adefovir dipivoxil (ADV) antiviral therapy.


Only one report links phenylpropanolamine consumption to an intracerebral hemorrhage in a patient with an AVM.


Strategies to prevent hyponatremia in children during urological procedures, with emphasis on the importance of reserving free water as the irrigation fluid are discussed.


SUMMARY OF BACKGROUND DATA: Spinal pain, caused by an infective mass, developed in a 39-year-old man 3 months after an epidural injection for low back pain.


This patient received chemotherapy (mitomycin C, 5-fluoruracil, and cisplatin) and reached a good partial response.


The prosthesis may be responsible for blood seeding infection and not only a mere victim.


The immunosuppressive effect of intensive polychemotherapy may play a significant role in accelerating the malignant transformation.


This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.


The low ionized calcium was unsuccessfully treated with several doses of calcium levulinate but successfully treated with 1 alpha-hydroxycholecalciferol.


Clioquinol intoxication occurring in the treatment of acrodermatitis enteropathica with reference to SMON outside of Japan.


We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia.


A 16-year-old girl with erosive, polyarticular JRA showed no detectable change in her articular disease following nine exchanges.


Twenty-three patients who experienced HCMV antigenaemia or DNAemia during or at the end of prophylaxis were included.


We report a case of a 23-year-old man who developed a vancomycin-induced anaphylactic reaction in the treatment of methicillin-resistant Staphylococcus aureus infection.


Accordingly, camptocormia is a dose-dependent side effect of valproate.


The cure rate of this disease has been reported to be lower than for non-drug resistant TB, and the use of new experimental drugs in combination therapy is warranted.


Shortly after this treatment was initiated, the mare appeared comfortable and no longer had signs of pain.


We study three such patients who successfully converted to mycophenolate mofetil, and briefly examine the evidence behind this option.


The rash progressed to TEN in 7 days, and she was transferred to a burn treatment center.


Fungal infections involving the pacemaker pocket after pacemaker implantation procedure are extremely rare.


Severe dapsone hypersensitivity syndrome.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Transvaginal ultrasonography is a very sensitive test and therefore is often performed as a first-line screening test.


We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.


Giant right atrial thrombi treated with thrombolysis.


Transluminal removal of a fractured and embolized indwelling central venous catheter in the pulmonary artery.


The patient was initially treated for presumed bacterial peritonitis but remained febrile and had persistent abdominal pain and peritoneal fluid pleocytosis, despite broad-spectrum antibiotic therapy.


CONCLUSION: Atovaquone should be added to the list of agents causing vortex keratopathy involving the corneal epithelium.


After drainage of the effusion she received combination chemotherapy with CDDP and VDS.


One child was briefly treated with imipramine, with similar results.


Unintentional ingestion of bupropion in young children has generally resulted in limited toxicity.


On the basis of these findings, a therapeutic approach to patients with drug-induced psychosis in PD is suggested.


Ocular ethambutol toxicity.


Infliximab is a chimeric tumor necrosis factor-alpha (TNF-alpha) monoclonal antibody, which has been used extensively in patients with rheumatoid arthritis and inflammatory bowel disease.


Laboratory tests excluded any underlying condition.


All three patients had previously experienced good responses to sumatriptan or zolmitriptan, but were limited in frequency of use by the authors.


Ten months prior to TAE the patient had undergone central bisegmentectomy for hepatocellular carcinoma with resection of the extrahepatic bile duct.


The patient required s.c. epinephrine and i.v. diphenhydramine, methylprednisolone, and ranitidine.


A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.


We also report a sixth case, involving an adult with an intramuscular coenurus.


It has many known toxicities and has been reported to cause anaphylaxis.


Possible reasons and clinical significance of this complication are discussed.


Subconjunctival and external hemorrhage secondary to oral anticoagulation.


Bronchoalveolar lavage (BAL) revealed lymphocyte alveolitis with a low CD4/CD8 ratio (0.36), consistent with an immunoallergic phenomenon, rather than the most often evoked toxic hypothesis.


The results of our investigation were inconclusive, but suggested that the endoscope could have been responsible for some of the cases.


Several alternatives presently exist for patients considering surgical rhinoplasty.


Nevertheless, the symptoms often go unrecognized and patients remain undiagnosed for years, not receiving the highly efficacious colchicine therapy; their histories often include multiple laparotomies, laparoscopies, and psychiatric evaluations.


During his hospitalization he experienced bloodstream infections including fungemia due to Trichosporon mucoides and prolonged undulating fever despite antifungal and antibacterial treatment.


Etanercept was stopped, and CD responded well to standard treatment.


The 171 patients were treated for a total of 4005 months, giving an incidence for severe infection of 3.30/100 patient-years (95% CI 1.65-5.90).


Nineteen cases of unusual enhanced vincristine neurotoxicity related to itraconazole have been reported in children.


The use of modern multiagent therapy often makes it difficult to appropriately apportion blame for causation of specific side effects.


At the end of each vitrectomy, 0.4 mg of gentamicin, 1.0 mg of cefazolin, and 0.32 mg of dexamethasone were injected into the vitreous cavity.