Oral etoposide remains an effective palliative agent and its usage should not be excluded without most careful consideration of the risks.


Nosocomial malaria and saline flush.


A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.


Her clinical status improved with urgent thrombolytic therapy (with tisokinase and urokinase) and anticoagulation therapy (with heparin and warfarin), and her life was saved.


Refractory pouchitis developed in all patients as well as protracted symptoms of diarrhea, abdominal pain, joint pain, and incontinence.


In four of five children who took the drug as scheduled, a cytolytic effect was observed.


Conversely, bile reflux and nitrite and N-nitrous compounds caused by abnormal bacterial growth in the gastric stump may play a role in inducing mucosa-associated lymphoid tissue lymphoma.


Fundoscopic examination revealed only hypertensive retinopathy.


After the first oral dose of propranolol, syncope developed together with atrioventricular block.


In children, only a few cases with this complication have been reported.


Acute respiratory distress related to chemotherapy of advanced pulmonary tuberculosis: a study of two cases and review of the literature.


These findings support recent evidence identifying TNF-alpha as an inhibitor of autoantibody formation.


The only possible seizure-provoking factors were modest doses of lithium and chlorpromazine, which the patient was on, and family history of seizure in a brother.


The admission computed tomography scan of the chest revealed progressive interstitial infiltrates.


Despite aggressive therapy with amphotericin B, the neonate succumbed to overwhelming systemic candidiasis.


Differences in susceptibility may exist if either the criteria for either Pseudomonas or Enterobacteriaceae are used.


Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.


He was taken to the emergency department and given intravenous methylprednisolone sodium succinate and intravenous diphenhydramine hydrochloride.


Thrombocytosis associated with enoxaparin: A very rare cause in newborns.


This complication typically appears within the first days or weeks after initiation of therapy.


CLINICAL PICTURE: A 60-year-old Indonesian male presented initially with fever, acute confusion and rapidly progressive right upper lobe pneumonia 3.5 months post-liver transplant, and was diagnosed with pulmonary tuberculosis by positive sputum smear for acid-fast bacilli and tuberculosis culture.


RESULTS: All 4 high-risk corneal transplant patients experienced episodes of acute rejection that was successfully reversed with topical tacrolimus treatment.


An obese 53-year-old woman (height 167 cm, weight 130 kg) with metastatic breast cancer received high-dose chemotherapy comprising cyclophosphamide, thiotepa and carboplatin (CTC).


High dose corticosteroids have been the mainstay in the treatment of fulminant ulcerative colitis (UC) for a long time.


If confirmed, this observation may open new possibilities in intensive chemotherapy for patients for whom haematopoietic progenitors are difficult to harvest.


The reversible posterior leukoencephalopathy syndrome (RPLES) is a condition characterised by reversible neurological and radiological findings that has been associated with use of immunosuppressive, chemotherapeutic and more recently novel targeted therapies.


We report treatment of a 38-year-old man with minimal change disease (MCD) who developed pneumatosis intestinalis (PI) during administration of immune-suppressive agents.


Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.


Nephrotic range pseudoproteinuria in a tolmetin-treated patient.


This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.


Three such patients are described whose main features were uncontrolled seizures, progressive dementia, behaviour disorder, muscular pseudohypertrophy, and a relative paucity of localizing neurological signs or signs of raised intracranial pressure.


Physicians should be aware of the potential for the development of RS among children who are receiving long-term aspirin therapy for the treatment of systemic inflammatory illnesses.


In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.


To date little has been reported about the risk of therapy-related leukaemia (t-AML) in children receiving oral etoposide therapy.


A sweat test using pilocarpine iontophoresis revealed a marked reduction in the sweat response, which suggested a postganglionic sweating dysfunction.


Other potential causes of myopathy such as chronic renal failure and other drugs were ruled out.


A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.


The disease-modifying drugs he was taking, cyclosporin and methotrexate, were stopped, and the lymphoma resolved spontaneously without the use of chemotherapy.


We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.


Patients treated with 5-ASA compounds who experience acute inflammatory symptoms or clinical deterioration not related to their gastrointestinal disease should be screened to rule out a lupus-like reaction.


Enoxaparin-induced generalized exanthem.


However, this phenomenon has been largely limited to skin.


Two patients received blood products.


Gabapentin-induced mood changes with hypomanic features in adults.


The authors have been unable to find a similar previously published case.


Serious side effects are encountered in less than 5% of patients and this case carries one of the rarest, yet drastic, side effects of intravesical BCG.


Serotonin syndrome is an underreported complication of pharmacotherapy that has been relatively ignored in the medical literature.


The cerebrospinal fluid culture, which yielded a motile Enterococcus species, was believed to originate from the gut.


To our knowledge this is the first report that demonstrates histological abnormalities of the glomerulus associated with postoperative IFN-beta therapy for the malignant melanoma.


The mean CAPD dialysance was only 5.27 ml/min with less than 1% of an administered dose being recovered in the 24-hour dialysate.


The patient was found to have a sigmoidovesical fistula and underwent sigmoidectomy and partial resection of the ileum and urinary bladder.


Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.


Twelve patients developed central nervous system (CNS) depression, defined as National Cancer Institute Common Toxicity Criteria (NCI-CTC) neurocortical toxicity grade 2 or higher.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


Dose related growth response to indometacin in Gitelman syndrome.


Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.


Twelve patients with hematologic malignancies complicated by fungal infections were treated with liposomal amphotericin B (L-AmpB).


A 61-year-old man with early diffuse cutaneous scleroderma with myositis and progressive interstitial pneumonia developed generalized erythema with high fever 3 weeks after taking sulfamethoxazole/trimethoprim.


A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.


The mortality rate is as high as 21-48% according to a recent review.


The attack was successfully treated with aggressive bronchodilator therapy.


Hematologic evaluation disclosed pancytopenia: red blood cells 283 x 10(4)/mm3; white blood cells 700/mm3; and platelets 8000/mm3.


Within 10 minutes, the occluded artery was reopened by an intracoronary (i.c.) infusion of streptokinase, resulting in the disappearance of chest pain and normalization of ST segments.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Many different medical and surgical remedies have been tried but none have demonstrated reproducible success.


Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.


After commencing oestrogen at physiological replacement doses, the patient experienced a marked deterioration in both the severity and frequency of angioedema attacks.


For many schizophrenic patients, treatment with conventional antipsychotic agents is not fully effective, and one approach has been to increase the administered dose.


Neuroleptic malignant syndrome (NMS) is a rare but potentially serious complication of neuroleptic drugs.


The authors present a case of t-AML that developed in a child with metastatic neuroblastoma 18 months after he received oral etoposide, given for palliation purpose.


As termination was not an option for the family, the patient was extensively counseled and treated with oral ganciclovir.


We suggest that the specific immunosuppression used in renal transplant patients might facilitate the development of a dormant infection and in these patients the misleading presentation may delay the diagnosis.


The great majority of these patients were diagnosed with actinomycotic diseases during or after exploratory laparotomy, but rarely preoperatively.


Treatment of tardive dystonia with oral baclofen produces ambivalent and overall disappointing results.


However, the large majority of cases of leukemic transformation in ET are thought to be related to prior therapy, usually radioactive phosphorous or alkylating chemotherapy, and the development of AL in ET is extremely rare in the untreated patient.


CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.


DISCUSSION: Central nervous system (CNS) toxicity has been described with ifosfamide, with most cases reported in the pediatric population.


He was not rechallenged with the drug.


CONCLUSIONS: This case suggests that losartan can induce late-onset angioedema in patients with normal renal function and that the reaction can recur after initial resolution of the symptoms.


High-strength pancreatic enzymes have recently been implicated as a cause of colonic strictures in children with cystic fibrosis (CF).


A MEDLINE search from 1966 to December 2000 revealed no reports of toxic epidermal necrolysis, erythema multiforme, or Stevens-Johnson syndrome due to ofloxacin therapy.


Corneal scrapings were taken and the flap excised, and submitted for histopathologic examination.


We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.


In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.


Our report suggests the efficacy of PES as ACAD treatment of the unprotected LMCA.


A karyotype showed 1) the involvement of 12p, which should be related to the basophilia and/or to previous drug exposure, and 2) the unexpected presence of three different dicentric chromosomes.


Imipenem was given for 2 days, resulting in a total of 18 days of beta-lactam treatment, at which time he developed significant leukopenia (white blood cell [WBC] count 0.9 x 10(3)/microL).


Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.


Eosinophilic cystitis is a rare and poorly understood disorder.


Multicentric canine lymphoma in a 12-year-old keeshond: chemotherapy options.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21.


We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).


METHODS: Prospective, interventional, single case report.


The dermatomes below the Th9 lost all somatic sensation on the left side after the nerve blocks, but the patient was not completely relieved from the pain.


Electron microscopic analysis also revealed a minor population of small adipocytes, suggesting active differentiation or proliferation.


All-trans-retinoic acid (ATRA) has been proved to be an effective treatment for acute promyelocytic leukemia (APL), inducing remission in more than 90% of cases.


Therefore, careful handling of the conjunctiva with a nontoothed forceps is essential.


Two months after thymectomy she presented with progressive cognitive decline, asymmetric quadriparesis and ataxia.


The neuropathology of organ transplantation: comparison and contrast in 500 patients.


The ECG showed a coved ST-segment elevation in the right precordial leads V1-V3, a pattern mimicking BS.


Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.


From these, three patients with myopathy were found for a total of 303 patient-years of therapy, for an incidence of 1 in 100 patient-years (95%, confidence interval 0.2-3).


Diagnostic testing could not be completed due to lack of clinical response to dexamethasone.


During hospitalization, he was treated with regular insulin and 300 mg/day of acarbose.


The process healed after surgical treatment and chemotherapy for 1 year.


Minoxidil, hypercoagulability and thromboembolic disease of the lung.


The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.


The patient was diagnosed with bilateral acute angle glaucoma, and despite aggressive medical and surgical intervention, the patient did not have her vision restored to normal.


Rhodococcus equi pulmonary-central nervous system syndrome: brain abscess in a patient on high-dose steroids--a case report and review of the literature.


A total of 1.5% (n = 41) and 2.0% (n = 52) of patients were receiving fluoxetine or tricyclics (amitriptyline or nortriptyline, n = 31; imipramine or desipramine, n = 16; protriptyline or trimipramine, n = 5).


Heparin-dependent antibodies and thrombosis without heparin-induced thrombocytopenia.


The Naranjo probability scale suggests a highly probable relationship between AIN and pantoprazole therapy in this patient.


BACKGROUND AND OBJECTIVES: The occurrence of concomitant intracranial pathology in a patient with postdural puncture headache (PDPH) is rare.


To determine the clinical significance of this organism, we reviewed the records of all patients whose blood cultures were positive for E. avium who were seen at our institution from 1986 through 1991 and identified nine cases of bacteremia due to E. avium.


Keratitis in methamphetamine abusers.


Airway obstruction complicating esophageal stent placement in two post-pneumonectomy patients.


We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).


During the follow up period we did not observe residue or recurrence of the ptosis.


Data of drug monitoring demonstrated rapid metabolism and/or distribution of KW-2149 with a short half-life and the emergence of the cytotoxic metabolites M-16 and M-18.


Drug eruption associated with sulfonamide treatment of vertebral osteomyelitis in a dog.


It seems that the anti-cancer agent evoked inflammation at the visceral pleura and the subject inhaled massive air flow into the systemic circulation.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Capecitabine (CAP) is a pro-drug of 5-FU and peripheral neuropathy associated with CAP has not been reported.


METHODS: A 79-year-old woman was hospitalized in our unit with posterior thoracic pain and urinary retention of 72 hours duration.


Strychnine poisoning in an adolescent.


In those patients who found the commercially available cream uncomfortable, a 1% clotrimazole suspension formulated in artificial tears was used and found to be well tolerated.


Adverse events with anti-epidermal growth factor receptor therapy mainly involve the skin.


Initial treatment with itraconazole resulted in exacerbation of clinical signs.


Intravenous bolus administration of magnesium (Mg) sulfate, followed by intramuscular Mg repletion, abolished the digitalis-toxic arrhythmia.


The hypertrophic adipocytes were twice as large as those from normal subcutaneous areas and contained numerous small lipid droplets.


Between 1993 and 1997, 52 patients (age 16-77 years) with solid tumours were treated with ifosfamide in dosages ranging from 3 to 5 g m(-2) q3w when given in combination schedules and up to 12 g m(-2) q4w when given as a single agent.


In this paper, the authors present a case in which the current American Society for Regional Anesthesia and Pain Medicine guidelines were strictly followed with respect to withholding and reintroducing warfarin and enoxaparin after an epidural steroid injection, but the patient nevertheless developed a spinal epidural hematoma requiring emergency surgical evacuation.


Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.


In addition to severe vegetative anticholinergic symptoms, the clinical picture is often dominated by a toxic psychosis with hallucinations, disturbances of orientation, and psychomotoric agitation, aggression, or anxiety.


Asthmatic medications can place the patient at risk of dental erosion by reducing salivary protection against extrinsic or intrinsic acids.


Only a few reports of overt jaundice are associated with streptokinase.


The infants in the other two reported cases also died, which suggests that TEN in early infancy has an extremely poor prognosis.


Although the cardiotoxicity of 5-FU is well documented, there is little published data about cardiovascular adverse effects of Capecitabine.


A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.


Recognition of this acute drug-induced state can lead to appropriate short-term pharmacotherapy and can prevent misdiagnosis of a major affective disorder or schizophrenia.


In this uncontrolled series of patients with recalcitrant palmoplantar pompholyx, methotrexate was an effective treatment and acted as a steroid-sparing agent.


To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently.


Treatment of the underlying cause and supportive care constitute the basic principles of management of disseminated intravascular coagulation.


These disorders may be the basic clinical manifestation of cancer or may result from vigorous cancer treatment.


One patient had an implant of serous papillary carcinoma of low malignant potential at the trocar sites after laparoscopic oophorectomy.


Hypersensitivity reaction to sulindac (Clinoril).


We encountered a child who was intolerant to multiple commercially available preparations of pancreatic enzymes and, hence, desensitization was attempted, with success.


Two patients had a history of schizophrenia.


The multiple comedones and ruptured epidermoid cysts are newly reported adverse effects of imiquimod therapy.


Its disadvantage is that therapy may be necessary for several months.


Exfoliative dermatitis secondary to tobramycin sulfate.


Twelve hours after admission, "diabetic ketoacidosis" was diagnosed on the basis of elevated glycaemia, glycosuria, ketonuria and a low bicarbonate blood level, which led to treatment with fluids and regular insulin infusion.


In the highly active antiretroviral therapy era, an increasingly large number of HIV-infected patients are developing non- AIDS-defining cancers (NADCs).


His symptoms of amnesia resolved approximately 6-7 hours after discontinuing the propafenone therapy.


These agents have potent cytotoxic and immunomodulatory effects and are useful in the treatment of a variety of conditions, including inflammatory bowel disease.


No other endogenous or exogenous cause for the gynecomastia could be found except for the theophylline.


The obligatory use of fluoroscopy for placement of epidural steroids is controversial.


Clonazepam in the treatment of prepubertal children with panic-like symptoms.


We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.


During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.


We recommend that fluorinated glucocorticosteroids should not be used on the face of infants and children.


The growing number of United States Food and Drug Administration-approved antidiabetic agents provides a wide range of therapeutic options, both as monotherapy and combination therapy, for treating hyperglycemia in patients with type 2 diabetes.


We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.


This case raises the possibility that chronic exposure to cyanoacrylates, the adhesive agents in industrial strength glue, may be associated with the development of acute lymphoblastic leukemia in humans.


SETTING: Hospital.


A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.


The association of NEH and the use of cytotoxic agents for SLE or other autoimmune diseases has not been reported previously.


Whether this represents a cause-effect association or a chance occurrence is unknown.


Because there is no shortage of intravenous thiamine, it should be administered with TPN even if MVI is not available.


A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.


The other patient developed transient intraoperative hypertension immediately after inadvertent submucosal injection of concentrated epinephrine.


Desipramine-associated SIADH in an elderly woman: case report.


Two reports of spindle coma are noted with alcohol and imipramine.


Cefuroxime-induced immune hemolysis.


To our knowledge, hyperpigmentation of the skin--and especially of the tongue--has not been reported so far.


We report 4 cases in patients with Cystic Fibrosis (CF) associated with totally implantable venous access device system (TIVADS).


Malignancy, infection and cardiomyopathy were excluded as causes of dyspnoea.


John's Wort by adolescents with a psychiatric disorder.


For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed.


OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.


The buried bumper syndrome is a rare and late complication of percutaneous endoscopic gastrostomy tube placement.


Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease.


Hemodiafiltration with a high-flux polysulfone membrane is a novel and safe treatment modality for vancomycin overdose in pediatric patients.


We report a 38-year-old woman with a history of smoking and pre-eclampsia in her previous pregnancy, who suffered a non-Q infarction at 18 weeks of gestation.


Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.


Given the limited experience with this agent in treating behavioural disorders associated with DLB, further studies are warranted.


The case is reported of eosinophilia-myalgia syndrome and polyneuropathy associated with myeloperoxidase specific antineutrophil cytoplasmic antibody.


We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.


Electrical proarrhythmia with procainamide: a new ICD-drug interaction.


We suggest that this form of treatment is of value for cholangiocarcinoma.


CONCLUSION: Prolonged unsupervised use of glucocorticoid ocular drops may result in Cushing's syndrome and its numerous associated complications.


This responded well to steroids and cyclophosphamide.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


No other site of invasive aspergillosis was evident.


Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.


Osteomyelitis of the fibula due to septic embolism: a rare complication of a graft enteric erosion.


PATIENT AND HISTORY: A 58-year-old man with GIST metastatic to the right lobe of the liver, treated with tyrosine kinase inhibitors, underwent a right hepatectomy requiring multiple transfusions.


Cardiac ischemia is a well-known and serious complication during surgery.


One patient had a lower average heart rate and two patients had lower average mean blood pressure values during propranolol treatment, none of which was clinically significant.


Collected cases are reviewed from the literature, and the common features are summarized.


Classification included dry (7%), mild (48%), moderate (39%), and severe (6%).


The pharmacist conducted a thorough medication review, which revealed the use of several herbal products, including St.


Minor reactions to the drug are very common, but severe idiosyncratic reactions are rare considering the large number of patients taking this drug worldwide.


Early phase-II semi double-blind study of the new alkaline propanolamine derivative enciprazine (short communication).


Thirteen patients with squamous cell carcinoma (SCC) and 3 patients with non-SCC who had recurrent/metastatic disease received S-1 monotherapy as outpatients.


Isotretinoin teratogenicity.


Laryngeal necrosis after combined chemotherapy and radiation therapy.


However, the composition of the mixture had been modified by the manufacturer in the past 5 months, with addition of boldo leaf extracts.


Treatment of atenolol overdose in a patient with renal failure using serial hemodialysis and hemoperfusion and associated echocardiographic findings.


The authors documented maternal intake of diazepam in the range of 40-60 mg/day for a duration of 4-27 weeks prior to delivery.


INTERVENTION: Intravenous pyridoxine was used in five episodes.


A 55- year-old man had been followed for chronic hepatitis B infection for 10 years at another institution.


DISCUSSION: Both cases met Stembach's criteria for serotonin syndrome and had serious extrapyramidal movement disorders.


An amiodarone optic neuropathy has been described.


BACKGROUND: Controversy exists regarding the timing of thrombolytic administration and rupture rate.


Camptocormia improved within a week after the reduction of the plasma valproate level to about 300 mumol/l.


Patients received infliximab infusions at a dose of 5 mg/kg, initially at weeks 0, 2 and 6 and subsequently at 8 weeks intervals in combination with an immunomodulator drug.


Implications for professionals who care for lactating women are discussed.


BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.


The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.


Presentation of 2 cases and review of the literature.


Methotrexate-induced diffuse interstitial pulmonary fibrosis.


The mechanism behind the development of the cutaneous lesions is unclear, and could have either a casual clinical association or be related to the study drug.


CMV reactivation is frequently observed in acute flares of ulcerative colitis (UC), particularly those which do not respond to intravenous steroids.


Danazol at 400 mg per day was therefore again administered.


An asymptomatic HIV-infected woman experienced right-sided renal colicky pain during treatment with indinavir.


We present four cases in which the use of heparin was associated with hyperkalemia and discuss the pathophysiology.


Fluoxetine suppresses human cataplexy: a pilot study.


In most of these studies, the effect of acarbose (on reactive hypoglycemia) was evaluated over several hours postprandially or after oral glucose load.


We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).


We present a case in which dipyridamole induced high-grade atrioventricular (AV) block that responded promptly to intravenous aminophylline but not to atropine.


The authors report a world class runner who sustained a rupture requiring surgical intervention.


Warfarin was discontinued and restarted at 7.5 mg/wk.


Sequencing of the mitochondrial polymerase gamma gene (POLG1) revealed four heterozygous substitutions, two of which have been identified in cases of Alpers-Huttenlocher disease.


Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.


The authors describe their use of midodrine in a dialysis patient for the longest period of time reported up to now, documented by a pharmacokinetic study, confirming long-term both clinical efficacy and safety of the drug.


We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.


Persistent triamcinolone acetonide particles on the posterior lens capsule after intravitreal injection.


Its use is however not without adverse effect particularly bone marrow aplasia leading to varying degrees of cytopenias predominantly anaemia.


However, 3 months after withdrawal of treatment, the patient still showed clinical and laboratory symptoms of systemic lupus erythematosus.


During the 12th week of treatment she showed transient thyrotoxicosis.


Methotrexate-induced liver cirrhosis.


It has been suggested that PPE caused by cytarabine does not recur with subsequent cytarabine re-challenge.


Arthroscopic posterior cruciate ligament reconstruction may carry certain risks of complications, including injury to the neurovascular structures in the popliteal region.


The occurrence of symptoms that could be ascribed to an acute coronary syndrome should always be taken seriously during the first rituximab infusion and investigated aggressively.


Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).


We recommend routine follow up by ECG of patients over the age of 50 treated with carbamazepine.


They cause impairment of hepatic glucose output and delay in intestinal absorption of carbohydrates.


Modern ergotism.


While in remission the patient developed acute leukemia.


The granular layer was preserved and, in some areas, hypergranulosis was found (Fig.


However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.


Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.


All patients were given pharmacologic doses of vitamin D, had reduced baseline levels of renal function, and became hypercalcemic with acute renal failure.


Withdrawal of lansoprazole lead to prompt and sustained relief.


While mortality from trauma increases, there has been a decline in mortality from cardiovascular and cerebrovascular diseases which parallels advances in antithrombotic and anticoagulation therapy.


A 66-year-old woman was diagnosed as having pulmonary adenocarcinoma with malignant pleural effusion following investigations for cough and dyspnea.


Carotid artery dissection in ergotamine abuse.


Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.


Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli.


Minor trauma to the tissue, such as tooth extraction, can trigger life-threatening laryngeal edema.


Two patients developed posterior subcapsular cataract.


Skin necrosis secondary to low-molecular weight heparin in a patient with antiphospholipid antibody syndrome.


A 53-year-old postmenopausal woman, who had a family history of cryptogenic liver cirrhosis, was diagnosed with osteoporosis, and started on the selective estrogen receptor modulator (SERM) raloxifene 60 mg/day orally.


Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.


The response to pain-related treatments and to preventive drugs was poor in the symptomatic as well as in the primary cases.


METHODS: Retrospective consecutive noncomparative case series.


It is suggested that many of the reported side-effects of o,p'-DDD may be due to hypoadrenalism and may be controlled by greatly increasing the steroid replacement dose.


With careful parental support, his sodium levels remained stable for many years on a fixed dose of DDAVP and a supervised fluid intake of 2.5 l/day.


CONCLUSIONS: Prompt and appropriate identification and intervention are essential for successful management of SS and NMS.


In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.


Finally, after 9 years of infection, the diagnosis of seropositive RA was made in this HLA-DR1 positive patient.


Severe corneal toxicity after topical fluoroquinolone therapy: report of two cases.


Three of the five patients had undergone endoscopy.


The mean hematocrit level in the study population was 19.8% before therapy and 31.5% after therapy.


The diagnosis of encephalomyelitis was made on day 3 after methotrexate administration, and by day 6 mechanical ventilation was begun secondary to ascending paralysis.


The effect of fluoxetine, a potent and specific serotonin reuptake inhibitor, on NREM eye movements is postulated to derive from potentiation of serotonergic neurons that inhibit brainstem "omnipause neurons", which, in turn, inhibit saccadic eye movements, thus resulting in disinhibited release of saccades.


CONCLUSIONS: De novo inflammatory bowel disease should be considered in patients in whom chronic diarrhea develops after an orthotopic liver transplant.


These data further suggest that degradation by the ubiquitin-proteosome-mediated system plays a role in the elimination of the DPD protein.


Fever was a constant finding, frequently accompanied by signs of central nervous system dysfunction.


Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma.


CONCLUSION: An indium (111) DTPA flow study is a non-invasive, safe and patient friendly diagnostic method which can be of great help in the evaluation of pump- or catheter-related complications and does not need to interfere with the delivery of CITB.


Video game epilepsy is considered to be its variant or a pattern sensitive epilepsy.


A 35-year-old man with refractory low grade diffuse centroblastic centrocytic non-Hodgkin's lymphoma was treated accidentally with an overdose of multiple chemotherapeutic agents.


Renal arterial thrombosis, usually in association with aortic thrombosis, has been reported as a result of prolonged neonatal umbilical artery catheterization.


The management of the patient's withdrawal symptoms is described.


Risperidone appears effective in controlling agitation in patients with dementia and has a relatively benign adverse-effect profile, but more clinical trials are needed to elucidate its role for this indication.


A marked decrease in uterine size occurred within 12 months of insertion accompanied by resolution of the menorrhagia and dysmenorrhea.


BACKGROUND: Post-allogeneic haematopoietic stem cell transplantation (HSCT) membranous nephropathy (MN), a rare complication of HSCT, remains an ill-defined entity.


Four case reports presenting new acquisitions on the association between breast and endometrial carcinoma.


Conservative therapy with oxygen and metronidazole improved the PI symptoms.


Corticosteroid administration was ineffective, whereas a prompt response to cyclosporine was observed.


The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.


A middle-aged architect, suffering from familial, idiopathic, levodopa-responsive restless legs syndrome (RLS) progressively abused levodopa for 10 years, to the point of taking 20 tablets/day (4000 mg/day) for 6 months.


One week after suspension, ocular pressure of the patients was 17 and 18 mmHg, respectively.


Triptans are specific agonists of the serotonergic 5-HT(1B/1D) receptors that have increasingly been used in the treatment of migraine and cluster headaches.


After failure to respond to antibiotics, aminosalicylates and immunomodulators such as azathioprine and 6-mercaptopurine (6-MP), all patients were treated with infliximab.


It is estimated that 3-10% of children with acute lymphoblastic leukemia (ALL) experience acute, transient neurotoxicity during induction chemotherapy.


Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.


Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.


A follow-up cerebral angiogram demonstrated a small AVM arising off a branch of the pericallosal artery and a small arteriovenous fistula arising off the costal marginal branch.


Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.


Only a few cases of candidal abscess of the pancreas have been reported, none of them having occurred after an ERCP.


Upon subsequent reduction and discontinuation of phenobarbital, however, chlorpromazine was able to be reduced with no increase in target behaviors.


Two other members of the family who were on treatment for tuberculosis but had not taken isoniazid on the day of the episode were unaffected by the same meal.


High-dose methotrexate-associated acute renal failure may be an avoidable complication.


The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn.


Patients with vitamin B12 deficiency are exceedingly sensitive to neurologic deterioration following nitrous oxide anesthesia.


Successful intervention is seldom reported.


It is important to keep a high index of suspicion with regard to DIAN since it is usually rapidly reversible.


ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.


Patients in this age group receiving antimanic maintenance treatment should keep lithium serum levels as low as possible.


Eventually, his bowel was reduced to 40 cm of small intestine, including 5 cm of terminal ileum.


Children undergoing chemotherapy, postsurgical procedures and those with AIDS are at increased risk for developing this unique type of shock.


Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.


Levofloxacin-induced delirium with psychotic features.


While thrombolysis is a first-line treatment option in massive PE and acute MI, cardiopulmonary resuscitation (CPR) has been regarded as a relative contraindication for thrombolysis because of the anticipated bleeding risk caused by traumatic cardiocompressions.


Idiosyncratic pulmonary reactions to nitrofurantoin are not unusual, often presenting as eosinophilic pneumonia.


Phenytoin toxicity is an uncommon problem seen in clinical practice.


Despite premedication with dexamethasone prior to a second attempt at therapy, she again experienced similar symptoms after receiving 500 mL (78 mg) of cisplatin solution.


Ten days before hospitalization he had undergone minimally invasive cutaneous surgery for crusty lesions but had not received antibiotic prophylaxis.


Simultaneous scrofuloderma and intracranial tuberculomas: a rare presentation of systemic tuberculosis.


Insulin-induced lipohypertrophy: report of a case with histopathology.


Methadone-induced myoclonus in advanced cancer.


METHODS: Case reports and associated biopsy findings.


Two of the authors of the recent review were expert witnesses in the trial.


The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.


Energy-dispersive X-ray analysis confirmed the presence of calcium.


As described in previous reports, the most common adverse effects are pain, inflammation, and induration at the injection site, occurring in approximately 20-60% of patients.


A 37 year woman developed neuroleptic induced parkinsonism that persisted long after the drug had been discontinued.


Physicians should be aware of the potentially lethal side effects of dapsone.


However, in some patients, surgical removal of the gingival tissue overgrowth becomes necessary.


METHODS: This is a case report of a CPP treated by a pain physician who demonstrated aberrant drug-related behaviors and required large doses of controlled-release oxycodone.


In two cases, caspofungin was added as salvage treatment due to failure of trimethoprim-sulfametoxazole monotherapy.


We report on two girls, 3 and 13 years old, with acute promyelocytic leukemia (APL) who were successfully treated with all-trans retinoic acid (ATRA) 45 mg/m2/day.


A review of the literature of 68 case reports of acute leukemia following ovarian cancer is presented and 3 new cases are reported.


Neuroimaging in both diseases is characterized by large demyelinating lesions in the spinal cord extending over several segments, and/or in the brain often involving the locations of astrocytes water channels.


Both patients underwent successful thrombolysis after super-selective angiograms.


OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.


In view of the enormous, and potentially fatal, plasma concentration of the drug, charcoal haemoperfusion was undertaken as well as cysteamine therapy.


Inhaled corticosteroids may cause various adverse effects ranging from irritation to severe anaphylactic reactions and systemic contact dermatitis.


Diagnosis was confirmed by histological and mycological examination.


The profession must assume responsibility for studies to determine the safety of the methods of application of the hydrogen peroxide, salt and baking soda mixtures and disseminate this information for the public interest.


Because of a recurrence of paroxysmal atrial fibrillation, the dose of the drug was increased to 1.4 g/day; 24 hours later AVT with syncope developed but responded promptly to atropine.


Acute reversible ataxo-myoclonic encephalopathy with flecainide therapy.


Gabapentin for the treatment of neuropathic pain in a pregnant horse.


For these reasons vasoconstrictor imidazoline containing solutions should be prescribed with caution and kept out of reach of children.


Many combinations of methotrexate and folic or folinic acid have been used to limit the side effects of methotrexate therapy in psoriasis or psoriatic arthropathy.


Overdose with chloral hydrate: a pharmacological and therapeutic review.


Interestingly, the patient's mother had also experienced a generalised pustular dermatosis associated with hypocalcaemia during oral contraceptive use, which was diagnosed clinically and histologically as impetigo herpetiformis.


We report a case of portopulmonary hypertension in which the pulmonary hypertension resolved after initial orthotopic liver transplantation.


Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.


We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.


Subsequent scheduled phenobarbital administration allowed for a successful and orderly weaning of the continuous benzodiazepine infusion and adjunctive agents used in AWS management.


Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.


Early diagnosis of osteonecrosis is important to prevent irreversible bone and joint destruction.


Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.


OK-432 therapy is considered hopeful for treating viral skin diseases, even in immunosuppressed patients.


Three patients with T315I abl-mutated chronic myeloid leukemia (CML) or Philadelphia chromosome (Ph)-positive acute lymphocytic leukemia (ALL) have achieved clinical responses to doses of MK-04547 that are not associated with adverse events.


Imaging studies showed calcification and fibrosis of the involved muscles.


SUMMARY: A 29-year-old woman sought treatment from a pulmonologist for a dry, hacking, constant cough not relieved by fast-acting inhalers or narcotic cough medications that had lasted for three weeks.


A review of the literature suggests that this may be an unusual complication of thrombolytic therapy.


To our knowledge, this is the first report of this syndrome related to vinorelbine therapy.


Carbamazepine was discontinued upon admission, and the patient was treated with oral lactulose.


The 9 other reported cases of D-penicillamine induced rapidly progressive glomerulonephritis have been reviewed.


The right eye progressed to phthisis bulbi.


He was not immunocompromised, debilitated and had not had recent surgery.


We present two cases where successful thrombolysis of right heart thrombi and pulmonary embolism was accompanied by serious adverse events.


A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).


One percent lindane should continue to remain the preparation of choice for nearly all patients with scabies and lice, but dermatologists should appreciate that these views are not necessarily shared by all health professionals.


For drugs with a narrow therapeutic index such as chloroquine, recommended dosing regimens should be respected, and adequate information sources must be available where such drugs are dispensed by untrained personnel.


Ours is a 430-bed tertiary care teaching hospital, The Wellesley Hospital, Toronto, Ontario.


The development of safer and more effective means for VT control is progressing and is needed.


In one case, disulfiram was the only potential teratogen exposed to the fetus.


CONCLUSIONS: We report the first case of gemcitabine-induced LABD.


We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.


Treatment with terbutaline was continued for 13 days and was well tolerated.


None of the patients had loco-regional recurrence.


Interestingly in one of our patients, the arthritis was almost asymptomatic and did not spread to other organs.


Investigations in two patients have revealed excessive renal loss of magnesium.


Reports of colonic perforation as a result of the administration of calcium polystyrene sulfonate and sorbitol are rare.


We present a case of a 16-year-old female with Graves' disease who presented with massive bone marrow plasmocytosis mimicking multiple myeloma.


Microbiological and histopathological confirmation of acanthamebic keratitis.


One of the three patients underwent aortic valve replacement three times and progression of the prosthesis dehiscence was arrested with the use of corticosteroids.


This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.


Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.


Unusual coronary artery aneurysm and acute myocardial infarction in a middle-aged man with systemic lupus erythematosus.


We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.


Localized herpes simplex (HSV) type II following intra-articular corticosteroid injection is remarkable.


Radiation-induced osteosarcoma arising 20 years after the treatment of Ewing's sarcoma.


Effectiveness of milnacipran for the treatment of chronic pain: a case series.


Complete regression of the CIN was observable after 60 days of therapy.


We suggest, however, that routine screening in such patients may be important.


RESULTS: The mean age was 44 years (range: 23-67) and no sexual predisposition was noted.


We suspect that improper technique resulted in an inadvertent administration of an intrathecal baclofen bolus.


We report a 45-year-old Chinese man with CML and chronic hepatitis B virus infection, on imatinib treatment, presenting with herpetic rash and acute liver failure.


Corneal endothelial dysfunction associated with amantadine toxicity.


The side effects of MMF, such as bone marrow toxicity, have been reported.


They continued to rise for five more days before salicylate hepatotoxicity was suspected.


Oral administration of prednisolone at a daily dose of 30 mg (0.4 mg/kg) was effective to improve their renal function.


All four patients had been taking high doses of niacin (3.0-4.5 g daily) before the onset of symptoms.


There was no statistically significant difference between the incidence of the total CNS complications among the different organ transplant groups (p value > 0.10), but there was a statistically significant difference in the systemic complications among the organ transplant groups (p value < 0.001).


A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented.


This paper reports a case of fatal perhexiline maleate liver injury.


Disulfiram-induced hepatitis.


These patients were treated by the continuous administration of an estrogen-progestogen combination for 6 months.


Sequential patients arriving to our center within 3 hours of stroke onset who were treated with intravenous alteplase were screened for possible additional intra-arterial therapy using noninvasive neuroimaging.


Patient survival depends on prompt referral to a specialist burns unit.


A patient using ziprasidone with polydipsia, seizure, hyponatremia and rhabdomyolysis.


His recovery was uneventful.


Late repeat restenosis was treated with a third (Taxus, Boston Scientific, Maple Grove, Minnesota, USA) stent that was deployed through the previously implanted stent struts.


Eight of the children were exposed to lead-based paint, with seven due to dust from sanded lead paint during house renovations.


Her condition has improved with progesterone therapy.


Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.


Due to Quetiapine's particulars and the promising receptor profile concerning addiction medicine, we set out to examine the tolerability and efficacy concerning relapse prevention of withdrawn alcoholics suffering from craving and affective symptoms.


The posterior hyaloid became taut and partially detached after the third injection and was almost completely detached 1 year later.


This observation indicates the complex effect of HIV on joint inflammation.


The treatment was given on an outpatient basis without requiring prolonged patient sedation or immobilization.


We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.


In both our cases, such a regimen did not prevent the occurrence of endometrial polyps which, although histologically benign, were usually large and thought clinically to be malignant.


Thrombolysis was administered and the patient recovered uneventfully.


In transplant recipients, such tumors are more common and more aggressive but their treatment does not differ from the treatment of Merkel cell carcinomas in the general population.


Increasing evidence suggests that neurohumoral manifestations of heart failure may lead to insulin resistance, predisposing patients with heart failure to the development of glucose intolerance or worsening of existing diabetes.


Both patients had atrial flutter with 2 to 1 atrioventricular block that evolved into 1 to 1 atrioventricular conduction.


Measurements of the peripheral arterial circulation were made using the Doppler ultrasonic velocity detector.


Also required are high index of suspicion and importantly serum levels of aflatoxin.


Electrical, chemical, and thermal agents are the main causative agents of these burns.


Additionally, her clinical course was complicated with adenovirus-associated haemorrhagic cystitis and viraemia.


This is the first reported case of suspected DIAN due to cefuroxime.


Clinical aspects of Candida infection in denture wearers.


Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.


A 13-month-old child with lamellar ichthyosis and numerous cutaneous and systemic infections died following an abrupt episode of severe hypotension.


Her condition improved, and she was discharged after 22 days.


The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.


The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.


Reduced vision secondary to pigmented cellular membranes on silicone intraocular lenses.


Fungal infections were more likely to be associated with abdominal devices, to have a local rather than systemic infection, and to have a longer duration from the original implant to presentation.


His diagnosis was reconfirmed and then treated with Pentostatin.


Marginal crack after intravitreal bevacizumab for myopic choroidal neovascularization.


Adverse effect of verapamil in myasthenia gravis.


Twenty-six (of 40 successful) patients indicated that they favored the night-time regimen mainly because it was less complicated.


This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.


She responded well to Sodium valproate.


Laboratory investigation confirmed prior exposure to CMV, EBV and HSV and suggested drug-induced immunological suppression.


The propensity of this disease to simulate gynecological malignancies has been described previously.


The day after the infusion, she no longer complained of diplopia, and her ophthalmoplegia had improved dramatically.


Valproate-induced hyperammonemia as a cause of altered mental status.


Two of the patients who had acute renal failure while receiving ACE-inhibitor therapy experienced a recurrence when rechallenged with such therapy.


RESULTS: We recently experienced a case of fatal erlotinib-induced ILD, diagnosed based on clinical and radiologic findings, which occurred in a patient with radiation fibrosis.


However, hepatotoxicity is extremely rare.


They also raise issues of patient education for self medication and access to emergency dental services outside normal working hours.


Patient beliefs that prescribed medication has limitations and that natural products are safe contributed to the use of herbal remedies.


CONCLUSIONS: Herpes zoster reactivation may occur following LASIK.


Physicians treating patients with methotrexate for juvenile rheumatoid arthritis must be aware of this extraarticular side effect.


Iatrogenic Cushing syndrome after epidural triamcinolone injections in an HIV type 1-infected patient receiving therapy with ritonavir-lopinavir.


DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.


Clinicians need to be aware of this potential side effect especially in children undergoing major surgery.


OBJECTIVES: To describe therapeutic cannabis use among patients with chronic pain.


We describe a case of acute gouty arthritis in a 71-year-old man with chronic renal failure who was treated with RFA for a HCC lesion and who had hepatitis B-associated cirrhosis and mild renal insufficiency.


We present four cases of iatrogenic epidural spinal abscess directly caused by externally introduced catheters or probes.


Successful desensitization to high-dose methotrexate after systemic anaphylaxis.


Effect of clozapine in severe tardive dyskinesia: a case report.


A complete remission was achieved twice.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration.


The treatments have been reasonably well tolerated with some acute skin toxicity.


We report an 18-year-old male patient who developed chronic hepatitis C after blood transfusion and had testicular dysfunction after irradiation for a testicular relapse of childhood acute lymphocytic leukemia after cessation of maintenance therapy, and the initiation of testosterone replacement therapy at puberty.


The patients differed with regard to risk; one patient had existing cardiopulmonary disease, and the other was free of such risk factors except liver disease.


Based on these data, we conclude that PSL therapy can ameliorate primary nephrotic syndrome in patients over the age of eighty years.


Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.


Leukopenia and agranulocytosis are well reported and dangerous haematological side-effects associated with the use of typical and atypical antipsychotics.


While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.


Two unsuccessful attempts were made to repair the valve which was finally replaced, requiring cardiopulmonary bypass of 317 min.


Lorazepam 2 mg was given with significant improvement.


Magnetic resonance imaging revealed regional kyphosis and large swollen paraspinal muscles impinging on the spinal cord without epidural hematoma.


Awareness of this potentially serious complication of chemotherapy can facilitate timely recognition of leukoencephalopathy with the use of magnetic resonance imaging.


On day 1 of admission, the patient exhibited a diffuse urticarial rash over his trunk and extremities.


Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS).


Upon rechallenge with clomiphene 3 months later, she again developed bilateral anterior uveitis.


All six patients have 6/6 best corrected vision.


We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.


In animals, increased dietary sodium reduces renal toxicity.


We report marked QT prolongation and torsades de pointes in a setting of flash pulmonary edema resulting from acute myocardial ischemia in a patient who was being treated with dofetilide for atrial fibrillation.


The day after methotrexate administration, the patient complained of severe back pain and urinary retention.


An associated transient pancreatic dysfunction was also noted.


A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.


Since an interaction between fluvoxamine and tizanidine, prescribed by another clinic, was suspected, fluvoxamine was replaced with milnacipran 50 mg day(-1).


Heightened seizure susceptibility associated with brain dermoid cyst and the administration of human chorionic gonadotropin (hCG).


Colonic necrosis is known as a rare complication following the administration of Kayexalate (sodium polystryrene sulfonate) in sorbitol.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Severe hepatitis caused by cyproterone acetate.


Transient TRH deficiency after prolonged thyroid hormone therapy.


Management of the hypertension required large doses of antihypertensive agents, including sodium nitroprusside, for six postoperative days.


Use of high-dose intravenous immunoglobulin in systemic lupus erythematosus: report of three cases.


Operative mortality was 64% in the prosthetic mitral thrombosis and 20% in the aortic one.


Two-thirds of the chronic cases improved markedly.


Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.


This is the first CT demonstration of widely disseminated living cysticerci in brain and muscles.


Five months later the patient was diagnosed as MH-susceptible by the in vitro caffeine and halothane contracture test.


Cultures of both the cerebrospinal fluid and aspirated liver abscess isolated MRSA.


A patient with diffuse and focal cerebral dysfunction was found to have absent peripheral pulses.


PTH was significantly higher in these patients than in 150 normal subjects.


This case report describes a patient with Turner's syndrome receiving systemic androgen therapy who experienced marked gingival enlargement, bleeding, and discomfort.


We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.


Given the immune-mediated processes in psoriasis and psoriatic arthritis, patients with these disorders may benefit from infliximab therapy but may also suffer from an increased risk of infection.


Before the myocardial infarction, the patient was in good condition, normotensive, non-diabetic, non-obese.


The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.


No severe side effects were observed in the liver, kidney, blood or the eyeground.


Although the treatment of choice for autoimmune hepatitis is glucocorticoids, their side effects make long-term use undesirable.


This case report is the first to describe a possible interaction with glipizide.


Immediately after the intubation, she suffered cardiac arrest.


While he agrees that systemic antibiotics should be avoided, he also would not prescribe ear drops.


We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.


Of these 75% were males.


After other potential causes of liver toxicity were excluded, TMP-SMX was determined to be the cause of his acute liver toxicity.


Prompt diagnosis using histology, serology, and PCR analysis allows prompt introduction of therapy and an improved prognosis.


The criterion for TD was a score of > or = 3 on one item or 2 on two or more items of the ESRS.


He received dimercaprol (BAL) and calcium disodium edetate (CaEDTA) for two five days session.


Chest wall actinomycosis in association with the use of an intra-uterine device.


Agranulocytosis is a disorder characterized by a severe decrease in the number of granulocytes in blood, that frequently occurs as an adverse reaction to some drugs.


Laboratory tests showed creatine kinase 144600 IU/L (reference range 24-195), myoglobin >3000 ng/mL (28-72), lactate dehydrogenase 7157 IU/L (230-460), aspartate aminotransferase 1115 IU/L (10-35), and alanine aminotransferase 205 IU/L (10-35).


A more serious development of adrenal insufficiency may occur upon the improper replacement of systemic steroids.


It may be due to several causes with different outcomes.


Both amoxapine and its active and major metabolite, 8-OH-amoxapine, appeared in breast milk.


Niacin maculopathy.


We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.


We describe a case of cholangiocarcinoma in a young woman, who presented with cholestatic jaundice following oral contraceptive ingestion.


True thymic hyperplasia is rare in adults.


No other cause of abdominal pain was identified.


Lead poisoning and recurrent abdominal pain.


How low can you go? Use of very low dosage of gold in patients with mucocutaneous reactions.


Captopril-associated "pseudocholangitis'.


The potential for fomepizole to inhibit retinol dehydrogenase, an isoenzyme of alcohol dehydrogenase essential to vision, did not appear to be clinically significant in this symptomatic methanol-poisoned patient.


Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD.


Encephalopathy and seizures induced by intravesical alum irrigations.


Radiography disclosed a lumbosacral intradural tumor.


C. striatum should be recognized as a potential pathogen in both immunocompromised and normal hosts in the appropriate circumstances, and appropriate antimicrobial therapy can quickly lead to resolution of infection.


Topical anesthesia-induced keratopathy after laser-assisted subepithelial keratectomy.


Indium-111 platelet scintigraphy in a patient with chronic disseminated intravascular coagulation.


Leukemogenesis related to chemotherapy of ovarian carcinoma: a review with three new case reports.


CASE SUMMARIES: Two patients who received ifosfamide-containing chemotherapy developed NCSE.


Bilateral anterior uveitis associated with clomiphene citrate.


We report for the first time the successful treatment of a patient who developed compensatory hyperhidrosis following sympathectomy using video assisted extension of the sympathectomy by application of botulinum toxin (BTX-A).


This article reports the occurrence of rifampin-associated thrombocytopenia in an indigent patient after a four-month lapse in therapy for pulmonary tuberculosis.


The objective of this paper is to report 5 cases of rhabdomyolysis (RML) in patients with acute leukemia (AL).


Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.


A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.


These areas were subject to repeated exposure to solvents.


Vasomotor reactions after gold sodium thiomalate are well recognized.


Neuralgic amyotrophy associated with antibiotic therapy.


We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.


It is severe enough to require discontinuation of therapy in 1-10 percent of patients.


Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.


Simvastatin-induced rhabdomyolysis following cyclosporine treatment for uveitis.


Transient bullous dermolysis of the newborn consists of congenital skin defects and a tendency for blistering of the skin and mucous membranes during the neonatal period.


We now report the first known cancer patient who developed life-threatening complications after treatment with topical 5-FU and was shown subsequently to have profound DPD deficiency.


A case report and review of the literature.


Drug-induced eosinophilia is a non-dose-dependent side effect of clozapine.


Antibiotic treatment should be continued.


The main concern is hypoglycemia, which can cause sudden incapacitation.


During IFN therapy, serum aminotransferases fell within the normal range and viremia (serum HCV-RNA) became negative after one year.


Because neurologic toxicity is becoming more recognized and DPD affects the catabolism of 5-FU, we discuss management issues and the use of new DPD inhibitors.


RESULTS: Withdrawal of the drug and initiation of corticosteroid drops resulted in prompt resolution of the choroidal detachment.


Histologically, the stratum corneum was thickened, with persistent nuclei together with countless small basophilic granules.


Spinal epidural lipomatosis: a case study.


No evidence of myocardial infarction was detected.


Botulinum toxin has been used in sporadic cases and seems to produce good results.


The association of infiltrative ophthalmopathy with primary hypothyroidism is uncommon.


We meningitis and epidural abscess after spinal bacteraemic patient.


We report a case of late cerebral toxoplasmosis reactivation, which was probably triggered by a brief course of corticosteroids, administered for chronic graft-versus-host disease (cGVHD).


Angioedema and dysphagia caused by contact allergy to inhaled budesonide.


Chickenpox follows a severe and often fatal course in adults with renal transplants.


A few non-gestational cases due to oral contraceptive use have also been reported.


In the transplantation literature, MMF has been noted to lower red blood cell counts.


EMG and NCV results and neurologic examination were suggestive for Guillain-Barre.


In addition, AZA probably potentiated susceptibility to this viral infection and may have inhibited adequate immunological defense.


Pseudomembranous colitis in a leukaemia unit: a report of five fatal cases.


Case report with neuropathologic findings.


Patients were injected with 2 mg/kg of sodium porfimer.


Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.


Although cytarabine exhibits pronounced in vitro virucidal activity against herpes viruses and has been successfully used in clinical treatment of severe herpesvirus infections, the present findings and a review of the recent literature cast doubt on the antiviral effectiveness of this drug, particularly in already immunosuppressed patients, and suggest instead that such patients actually have an increased risk for development of disseminated herpesvirus infection owing to further depression of host defenses by the drug.


Toxic epidermal necrolysis, a life-threatening reaction to certain types of drugs, is characterised by epidermal sloughing of more than 30% of the total body surface area.


During the anti-tuberculous therapy, visual loss can be related to ethambutol toxicity or the tuberculosis infection itself.


Granulomas and Histoplasma organisms were found in the histologic sections of the marrow aspirate.


Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.


Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.


Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used.


CONCLUSIONS: Atypical antipsychotic-induced diabetes does not always take a "type 2" presentation in which weight gain and insulin resistance are implicated.


The side effects in all patients have included varying degrees of anorexia, fatigue, ipsilateral forehead dermatitis, blepharitis, and conjunctivitis.


The observations suggest that testicular swelling and pain are side effects of desipramine.


Relief by naloxone of morphine-induced spasm of the sphincter of Oddi in a post-cholecystectomy patient.


In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.


However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.


CONCLUSIONS: Infectious endophthalmitis is a potential complication of intravitreal bevacizumab injection.


Though the syndrome was suspected early, attempts at reversing the hematologic and renal abnormalities were unsuccessful.


All psychotropic medications were held except for a benzodiazepine.


At 26 weeks' gestation, she was transferred to our center.


Conditioning as an adjunct in the pharmacotherapy of lupus erythematosus.


Prior to beginning therapy with these antiretrovirals, he was receiving VPA 250 mg 3 times daily, with his most recent VPA concentration measured at 495 micromol/L.


The thrombus was disrupted during cardiopulmonary resuscitation.


Paradoxical cerebral cortical hyperexcitability following flupirtine overdose.


Treatment of reflex sympathetic dystrophy (RSD) is primarily surgical.


Following the institution of intravenous therapy with acyclovir, the patient developed fever, hemoptysis, and a pleural friction rub.


We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.


We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.


The aim of this study was to evaluate whether corticosteroid use is the etiological agent in acute pancreatitis in patients with systemic lupus erythematosus, or whether it is related to the underlying connective tissue disorder.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


DESIGN: Retrospective case review.


Illness was severe in all three patients and one patient died even after initiation of doxycycline.


Relatively high levels of morphine-6-glucuronide were measured and all symptoms resolved promptly as the concentration of this metabolite declined.


We report a case of acute hyperphosphatemia secondary to rectal administration of sodium phosphate and sodium biphosphate (Fleet enema).


This syndrome has been previously reported following cisplatin-based chemotherapy.


Tooth brushing-induced seizures: a case report.


The INR should be monitored more frequently when bosentan is initiated, adjusted, or discontinued in patients taking warfarin.


Successful treatment using a jet-injection device.


Somatostatin could also be helpful in bilio-pancreato-intestinal fistula, but in this case its advantage over elective surgical treatment remains to be confirmed.


Cytomegalovirus is a common infection worldwide and in the immunocompromised individual it can be a major cause of morbidity and mortality.


While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.


We report on two patients with PPG following breast surgery who were successfully treated with low-dose cyclosporin (2.5-5 mg/kg per day).


In recent years, the association between breast and endometrial cancer has been the subject of many studies.


Her course was further complicated by exudative pleural effusion and pneumonia despite receiving 10 days of clindamycin therapy.


We present a 44-year-old female patient with generalised myasthenia gravis who developed progressive multifocal leukoencephalopathy.


Long-term lithium treatment attenuated the hypokinetic effect of reserpine in a patient with tardive dyskinesia.


Three cases with touch of an intact anterior vitreous face to the cornea following phacoemulsification had moderate corneal edema.


We postulate that in our patient, a subgaleal hemorrhage developed after vacuum delivery and possibly infected 11 months later, presumably from hematogenous seeding of an acute otitis media.


We present a case of photo-onycholysis in a patient treated with doxycycline for acne vulgaris.


Refractory hypoglycemia from ciprofloxacin and glyburide interaction.


Sexual dysfunction associated with intrathecal baclofen use: a report of two cases.


The photosensitivity is still present 3 years after the withdrawal of quinine.


CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.


After cessation of amantadine, the edema resolved, and the endothelial cell densities were <or=600/mm.


In rare patients, systemic absorption of inhaled tobramycin may be significant enough to produce toxic effects, such as renal and vestibular toxicities.


However, we have not identified previous reports suggesting interaction between MTX and COX-2 inhibitors.


We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.


The primary pathology was a spinal cord astrocytoma, grade II, with no intracranial extension.


Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.


Pregabalin is one of the newer drugs approved for the treatment of focal epilepsies.


A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.


We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.


We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.


This entity should be included in the differential diagnosis for renal transplant recipients with hypercalcemia, especially in patients who develop lung infections.


Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.


The ocular pressure of the second patient was 18.5 mmHg after a week, 21 mmHg after 2 weeks, and 23 mmHg after 16 days.


5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.


Occlusion of the right brachial and right femoral artery was ascertained by Doppler ultrasound.


It is derived from 6-mercaptopurine, and these two drugs are often used interchangeably.


This unusual psychopathology is probably encountered more by dermatologists than by mental health professionals.


Myocardial infarction is rare in pregnancy.


The patient was treated by local excision and corticosteroids were decreased.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


The Japanese literature was reviewed for reports on this allergy, and the occurrence due to budesonide was compared with that of other dermocorticosteroids.


This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.


Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.


Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.


Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.


The diagnosis was made on the classical appearance of "owl's eye" inclusion bodies on colonic and hepatic biopsies and, in addition, viral serology and polymerase chain reaction (PCR) analysis of the cytomegalovirus DNA copy number.


RESULTS: Ten cases of blebitis and 33 cases of bleb-associated endophthalmitis were identified.


One of the cases reviewed went to jury trial and the record of that case is in the public domain.


There have also been two cases of patients with hepatitis C associated with focal segmental glomerulosclerosis.


New onset rapid cycling bipolar disorder is rare in late life.


The fibrinolytic state was achieved with a combination of intravenous and intraarterial infusions of urokinase.


A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.


OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.


Possible mechanisms and preventive measures are discussed.


A report of retinal artery occlusion associated with mitral valve prolapse and pregnancy is presented.


CASE: A nulliparous woman with a long history of intrauterine contraceptive device (IUD) and recent Papanicolaou smear findings consistent with the presence of actinomyces presented with chronic vague lower abdominal pain, weight loss, poor appetite, and recent increase in abdominal girth associated with a large immobile pelvic mass.


We present a case of disseminated cryptococcal infection in a patient with pemphigus vulgaris treated with high dose corticosteroids as monotherapy.


The linear dimensions and SOMA scale were, respectively, 8 x 6 cm and 11 at 6 months; 4 x 4 cm and 7 at 12 months; and complete response with no measurable RIF and 1 at 18 months.


We describe a characteristic speech disorder identified in a large series of consecutive patients undergoing OLT.


Laboratory abnormalities were initially attributed to chemotherapy toxicity.


Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued.


Until more information is known about the safety of warfarin and azithromycin, caution is advised when the agents are given together.


Her mood improved significantly.


All-trans retinoic acid has recently been shown to induce differentiation of acute promyelocytic leukemia cells in vitro and in vivo.


A patient developed typical ECM after subcutaneous selfinjection of glatiramer acetate for multiple sclerosis.


Two patients had ampicillin-associated seizures.


Isoniazid causing breast tissue enlargement has been very rarely reported.


Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?


Aspirin sensitivity: the role for aspirin challenge and desensitization in postmyocardial infarction patients.


Tuberculosis can involve multiple organ systems concurrently.


Scapular upward rotation is predominantly achieved via a force coupling involving the upper and lower trapezius and the serratus anterior.


CONCLUSION: The present findings suggest that fluvoxamine can cause increased libido in some patients.


Allergic contact dermatitis to compound tincture of benzoin.


Ten patients received naloxone, 50% demonstrated clinical improvement in vital signs and CNS depression.


A coherent 84-year-old woman with occult CNV both eyes (OU) experienced decreased vision of 20/800 OU.


The predominant feature was the abnormally increased formation of both 3 mono- and 4 double unsaturated metabolites of VPA amounting in plasma to 58%-71% of the sum of VPA plus all analyzed metabolites (controls maximal 15%) and in urine to 34%-61% (controls maximal 10%).


This case report describes a 13-year-old male with diagnosis of autistic disorder and fetishistic behavior.


Continuing the treatment with 13-cis-retinoic acid without systemic steroid eventually cleared the systemic manifestations and skin lesions.


RESULTS: We report the case of a patient treated with capecitabine and radiation for rectal adenocarcinoma.


These potentially life-threatening phenomena have led to treatment discontinuation and the consequent reemergence of psychiatric symptoms.


DATA EXTRACTION: One author reviewed cases supplied by the other authors and abstracted information from published literature sources.


Forty-three of 101 outpatients with parkinsonism reported that they regularly experienced primary sensory symptoms, i.e., spontaneous abnormal sensations not caused by somatic disease.


The cases reported in the literature are all secondary to dental or periodontal disease.


Vitreous samples were obtained, followed by the injection of vancomycin 1 mg/0.1 ml and ceftazidime 2.25 mg/0.1 ml.


On day 7, blood obtained on day 4 was found to be strongly positive for HDAs.


We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.


The former consisted of massive biventricular hypertrophy with chamber obliteration.


The edema disappeared with discontinuation of the drug regimen and did not reappear during a subsequent six-month observation period.


Because there were no other obvious causes of renal failure in either patient, we propose that skeletal muscle ischemia developed during vasopressin infusion, followed by release of myoglobin and renal damage.


The patients received anticoagulation therapy and recovered completely.


Echocardiography revealed severe, global left-ventricular dysfunction.


Flap salvage is often successful if vascular complications are recognized and treated early.


Its ease of administration makes it an ideal drug to treat patients in the outpatient setting while maintaining adequate quality of life.


Multifocal osteonecrosis has a wide variety of etiologies, but is most often encountered in the clinical setting of corticosteroid administration, connective tissue disorders, transplantation, hemoglobinopathies and dysbarism.


In all the children with azotemia who were treated with aluminum hydroxide, there was a positive correlation (r = 0.90; P less than 0.01) between the serum aluminum level and the daily dose of elemental aluminum.


Methotrexate induced sprue-like syndrome.


Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).


The hepatitis C infection was eradicated, but he continued to be diabetic requiring insulin therapy during the follow-up.


The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.


A 22-year-old male, referred to us as a case of multi-drug resistant tuberculosis was diagnosed as allergic bronchopulmonary aspergillosis (ABPA) after serological and computed tomography confirmation.


We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.


Posterior reversible encephalopathy syndrome is a treatable and reversible cause of acute encephalopathy with blindness, as long as an early diagnosis is made.


We report a case of severe anemia, which responded well to steroid therapy, in a patient receiving IL-2 plus IFN-alpha for metastatic renal cell carcinoma.


We suggest that voriconazole may be a useful treatment alternative to the more traditional therapy with amphotericin B-based agents.


Implications for the neonate.


Bcr-Abl tyrosine kinase inhibitors (TKIs) such as imatinib or dasatinib produce high cytogenetic response rates in patients with Philadelphia-positive chronic myeloid leukaemia (CML) with a good overall safety profile.


A 27-year-old man with typical mitral leaflet prolapse syndrome was under medical care for eight years with ventricular arrhythmias resistant to various antiarrhythmic drugs.


Power spectrum analysis of heart rate variability is useful in this instance because it magnifies the trace and detects even minor disturbances.


She was subsequently rendered euthyroid with radioiodine treatment.


Thus, the LNG-IUS is a viable option and represents a real advance in the treatment of adenomyosis.


The action of valproate in GABA metabolism and in GABA neuronal networks could produce a similar result through a hyperrecruitment of GABA-mediated postsynaptic transmission.


All had a history of chronic graft-vs-host disease (cGVHD) and all had active manifestations of cGVHD at MN diagnosis.


The daily VPA dose was increased to 1500 mg, and olanzapine was introduced.


Analgesic agents and a change from intravenous to oral administration of cyclosporine were ineffective in controlling the pain.


In conclusion, myalgias were due to focal RML produced probably by a combination of factors, particularly the chemotherapy along with dehydration due to gastrointestinal complications, infection, and the use of diverse antibiotics.


Although the mechanism of the pressure rise is unknown, all eyes in our series were controlled with medical therapy.


In keeping with findings in the literature, the aortic wall in this case was damaged by secondary changes following irradiation and Bleomycin treatment.


Magnification revealed that these were scolices within cysticerci.


Her symptoms improved markedly, and follow-up arteriography 6 weeks later demonstrated resolution of the iliac dissections along with restoration of nearly normal lower extremity runoff vessels.


The patient recovered well, both cognitively and physically, and did not have any further symptoms in 1 year of follow-up.


However, to our knowledge, there are no accurate estimates of the incidence of CNV in other retinal vascular diseases, such as diabetic retinopathy.


This infection progressed despite treatment with antifungal regimens known to be effective, even in immunocompromised patients.


The mechanism of the decrease in plasma potassium induced by phosphate treatment was investigated in a 24-year-old hypertensive patient with hypophosphatemic osteomalacia, who was the youngest of four patients, belonging to a 23 number kindred of five generations.


Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.


Side effects recurred with sequential dosage adjustments so that doses > 10 mg were not tolerated.


We have reviewed the literature on drug-induced ocular pemphigoid and have added our experience with five patients with glaucoma who developed ocular cicatricial (benign mucosal) pemphigoid after treatment with various topical glaucoma medications.


Three cases of head and neck PTLD treated at our institution are described.


Bone marrow aspiration and biopsy were diagnostic of pure red cell aplasia on a background hypocellular marrow.


BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.


It includes a description of the complication, how it occurred, was recognized, and corrected.


Sorafenib, a multitargeted kinase inhibitor used for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinomas, received FDA approval in 2005.


Optic nerve sheath fenestration for a reversible optic neuropathy in radiation oncology.


They presented with circumscribed blue-grey pigmentation within acne scars confined to the back.


The importance of differentiation between primary and "therapy-linked" disease, and the difficulties in making such a distinction, are discussed.


The patient used the recommended dose regularly, and he described progressive proximal muscle weakness and generalized myalgias, which started 1 month before presentation.


The prevalences of hypertension, coma/unresponsiveness, seizures, and death were not as prominent in our study as previously reported, perhaps reflecting earlier recognition and intervention.


CONCLUSIONS: Some patients may thus have a spuriously low cell count and may be unnecessarily denied effective treatment.


The complexity of this situation can generate an impaired consciousness in the patients.


The patient was ultimately treated with a combination of leflunomide and foscarnet.


CONCLUSIONS: Because blebitis may be prodromal to endophthalmitis, aggressive antimicrobial therapy, perhaps with oral quinolones, is warranted.


One had cutaneous anergy in vivo and profound reduction on mononuclear cell proliferative and interferon responses to tuberculoprotein (PPD) in vitro; the other patient, who died two weeks after starting treatment, had relatively normal values for these measures of cell-mediated immunity.


CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.


Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.


Ischemic stroke associated with cough and cold preparation containing methylephedrine and supplement containing Chinese herbal drugs.


A 69-year-old female with chronic posterior uveitis was treated with cyclosporine while on concomitant oral simvastatin for hypercholesterolemia.


No re-occurrence of pancreatitis was observed in a 16 month follow-up.


After taking this treatment for 1 month, she presented with fever, diarrhea, localized edemas, generalized pruritic papular and erythematous rash and lymphadenopathies.


Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus.


Intraocular inflammation was minimal in all cases.