The literature is devoid of reports indicating that a reduction in the dosage or discontinuation of antidepressants of any chemical class produces symptoms of major depression within 2-4 d.


Four months after treatment was initiated, there was no evidence of recurrent fungal keratitis or endophthalmitis.


The median duration of subsequent remission was only 13 weeks, but six out of eight children receiving a second course of the drug combination achieved a further remission.


BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.


However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.


She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.


RESULTS: The loss of subcutaneous tissue in the injection areas was demonstrated and measured by high-frequency ultrasound.


Transcutaneous computed tomography guided core needle biopsy established the diagnosis of pelvic actinomycosis obviating immediate surgical intervention.


Case no. 1 showed features of photoallergy such as 1-month incubation period, decreased MED to UVA, strong positive photopatch test result, cross reaction to chlorpromazine, and angry back phenomenon found in allergic contact dermatitis.


Treatment of antibiotic-associated pseudomembranous colitis with metronidazole.


On the 4th day, the pattern of VWFMs was completely normalized and appeared to persist until the 10th day.


We present a case with important pharmacogenetic and pharmacokinetic aspects of antiretroviral therapy in a patient with high efavirenz concentrations, severe CNS side-effects and low lopinavir concentrations.


Reciprocal chromosomal translocations involving the MLL gene at chromosome region 11q23 are recurring cytogenetic abnormalities in both de novo and therapy-related acute myeloid leukemia (AML) and in acute lymphoblastic leukemia.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


Hand-made articulating spacers for infected total knee arthroplasty: a technical note.


Opioid drugs should not be administered for several hours before a diagnostic hepatobiliary scan.


Adenomyosis is an important cause of menorrhagia.


To our knowledge, this is the first reported case in Thailand.


We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.


One such case that was managed conservatively with success is reported.


Total resection revealed that the lesions were composed entirely of fatty tissue.


Both of these findings are due to the unique effects of rifampicin on steroid metabolism.


Both recovered after withdrawal of the drug.


Four years after 2-CdA treatment, the patient has psoriasis on only 1% of his body surface area.


Prolonged severe cholestasis induced by oxacillin derivatives.


Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.


Usefulness of antiplatelet drugs in the management of heparin-associated thrombocytopenia and thrombosis.


Two months later, at a follow-up visit, her serum cesium level was 1800 microg/dl, and her QTc interval was 494 msec.


The physiological complexities of deep-diving research are reviewed, as well as the neuropsychiatric symptoms of the high pressure nervous syndrome.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


Rare infusion reactions that resulted in the cessation of therapy have been described after cetuximab administration.


The hematomas resolved in the other patient, who delivered at term.


Histologic examination of the neoplasm was consistent with a high-grade pancreatic exocrine adenocarcinoma.


Guidelines for handling common scenarios in PD patients will be illustrated by 10 case histories.


Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.


The only recent change in their treatment was the introduction or increased dosage of zonisamide.


BACKGROUND: Most of the new fillers used for soft tissue augmentation in aesthetic dermatology are considered well tolerated, but very little data are available on their long-term tolerability, especially in patients receiving immunomodulatory therapy.


In all cases the presentation was atypical, and in two cases the course was protracted, leading to some visual loss from corneal scarring and opacification.


Every year they receive dilated fundoscopic eye examination.


We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.


Phase I and pharmacokinetic study of a novel mitomycin C analog KW-2149.


The drug was discontinued and papular lesions gradually disappeared.


Oral chemical burns caused by self-medication in a child: case report.


CONCLUSIONS: In selected patients, a continuous infusion of haloperidol may be a useful alternative for control of agitation and delirium.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Glaucoma from topical corticosteroids to the eyelids.


METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.


We describe a 37-year-old woman who was receiving temozolomide for treatment of metastatic melanoma.


These data indicate that lithium may limit the therapeutic efficacy of reserpine in tardive dyskinesia.


PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.


We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).


In the last decades there have been reports describing a transient form of constrictive pericarditis, which resolves without surgical therapy.


The diagnosis thrombocytopenia caused by common drugs can be difficult, requiring persistent, explicit questions.


A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.


OBJECTIVE: We describe the prolonged clinical benefit of murine chimeric antitumor necrosis factor (TNF)-alpha monoclonal antibody, infliximab, on pediatric patients with Crohn's disease and ileal pouch anal anastomosis (IPAA).


The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.


Rechallenge with chlorothiazide while on a sodium- and potassium-controlled balanced diet resulted in a decrease in serum sodium concentration (136 to 124 mEq/L) and plasma osmolality (283 to 261 mOsm/kg) within 18 hours.


The association of the use of certain androgenic steroids with hepatic neoplasms histologically resembling hepatocarcinomas, but characterized by lack of metastases and apparent reversibility, suggests the desirability of a new nomenclature for these hepatocellular lesions.


Periodic gynecologic assessment should be part of the follow-up of all women on long-term tamoxifen therapy.


We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab.


She underwent a thymectomy at 40 years of age to treat myasthenia gravis.


Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.


CASE: We report a 17-year old JRA patient with primary ovarian diffuse large B-cell non-Hodgkin's lymphoma (NHL).


Three possibilities existed to account for this outbreak: the positive cultures represented isolated events; there was one isolated event and a common source; or, all events were due to a common source.


Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.


Reported herein are two NMS patients with schizophrenia who were found to possess a CYP2D6 gene deletion allele (CYP2D6*5).


Cutaneous sarcoidosis during interferon alfa and ribavirin treatment of hepatitis C virus infection: two cases.


Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.


Myoclonus seen in the abdominal wall was segmental and considered to be of spinal origin.


We describe the case of a 56-year-old man who had high aminotransferase levels and anti-hepatitis C virus (HCV) antibodies.


Umbilical artery catheterization is often performed in critically ill neonates.


Several such HBV reactivations were reported after combined rituximab and multiagent chemotherapy for B-cell lymphomas.


The finding of decreased lymphocyte Mg and potassium contents proved the existence of cellular Mg depletion associated with normal serum Mg levels in five patients and with hypomagnesemia in the other two.


The use of 5-fluorouracil given in the usual manner appears to have been a failure.


We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.


Nitrates occur in high concentrations in some food and water.


A case of Sweet's syndrome following septic pulmonary emboli after high-dose chemotherapy for advanced testicular cancer.


Therapy to relieve the compression was disappointing.


Patient 1 also received a nine-month course of combined therapy with melphalan, procarbazine, and prednisone.


The uveitis is almost always interior, begins unilaterally and progresses to involve both eyes.


These neurological symptoms should be added to a growing list of important complications of DIHS/DRESS because of the high mortality rate associated with them.


One week after beginning of HAART, tacrolimus was discontinued during 18 days due Ritonavir interaction.


Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?


The organism was unusual in its resistance to chloramphenicol and ampicillin; however, it was sensitive to a sulfonamide and trimethoprim.


Test results from a skin biopsy specimen were consistent with a drug reaction.


The occurrence of acute hepatitis is best known for ketoconazole.


A diagnosis of tuberculous uveitis was established; the patient was treated with rifampin, isoniazid pyrazinamide, and ethambutol and etanercept was stopped.


It is stressed that ethambutol may act as a trigger factor to the toxic effects of Rifampicin.


The clinical features are described on the basis of four cases.


Biopsies from skin of normal appearance from 18 patients treated with carbamazepine and diphenylhydantoin were investigated by a direct immunofluorescence technique.


During the follow-up period of two months, there was transiently decreased MED to UVB, which became normalized after 1 month treatment with cyclophosphamide.


In 2 of the 3 cases the patients were also taking lithium carbonate and beta-blockers, both of which could have contributed to the incontinence.


Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.


There is a disagreement regarding imaging studies.


Two days later the patient developed visual hallucinations, ataxia, confusion and memory loss along with focal myoclonus, nausea and vomiting.


The severity of cutaneous and hematologic toxicity experienced by our patient has rarely been reported.


It is suggested that the long-term use of androgenic-anabolic steroids is the fourth cause of HAS, the majority of cases still being of unknown aetiology.


Intravenous sodium bicarbonate and furosemide, and intrarectal calcium polystyrenesulfonate were administered to correct the acidosis and promote potassium secretion.


OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.


In this report, we will describe the first case of obsessive-compulsive behaviour following oral corticosteroid treatment in a 75-year old adult male patient with pulmonary disease, but without previous psychiatric symptoms or organic brain disorder.


We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.


Timely diagnosis and management is crucial to maintain good structural and visual outcomes.


We therefore assume that the risk of severe neurological complications is underestimated.


The patients, a 4-year-old with microcephaly and severe retardation, a 1-year-old with cerebral dysgenesis, and a 5-year-old with spastic quadriplegia and mild retardation, all had seizures unresponsive to multiple anticonvulsant combinations.


Blood lead level was > 200 microg/dl.


In December 1998, he applied to our clinic for a follow-up examination.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Interstitial granulomatous dermatitis is most commonly associated with rheumatoid arthritis (RA) but may be induced by medications as well.


Physical examination showed slate gray discoloration of her skin, most pronounced on the face and neck.


We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.


Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.


This study reports the results of a retrospective review of the case records of 28 seriously ill patients who received intravenous cimetidine (generally 300 mg q8h) for the treatment of gastric discomfort and/or hemorrhage or for prophylaxis against stress-induced ulcers.


Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.


Thyroid function should be assessed before and during alpha interferon therapy in patients with chronic hepatitis C.


We present a patient who developed life-threatening Met-Hgb from the local anesthesia required during percutaneous endoscopic gastrostomy tube placement.


Progression of chronic myeloid leukemia to blast crisis during treatment with imatinib mesylate.


We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.


Persistent ashen-gray maculae and freckles induced by long-term PUVA treatment.


Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.


A case of tuberculous peritonitis complicating continuous ambulatory peritoneal dialysis (CAPD) in a 37-year-old man who presented with fever, abdominal pain, and a malfunctioning Tenckhoff catheter is reported.


We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.


As the number of cases of refractive surgery in Australia increases, optometrists will encounter this condition more frequently.


Diagnosed with diabetic ketoacidosis, he was given insulin and saline with discontinuation of all antipsychotics.


We encountered four patients who developed Acanthamoeba keratitis while wearing contact lenses that had been stored in homemade saline.


A 44-year-old woman with a previous diagnosis of multiple sclerosis presented with panuveitis and retinal perivasculitis.


We describe a case of significant and potentially toxic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with grade IV graft-versus-host disease (GVHD) of the GI tract.


PURPOSE: To report a case of herpes zoster ophthalmicus reactivation following laser in situ keratomileusis (LASIK) for myopia.


A bone marrow aspirate and biopsy confirmed the diagnosis of AA and suggested the existence of an immunological reaction at the level of marrow.


Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.


We describe a case of significant elevation of serum transaminases in a patient treated with 6-TG for a flare of Crohn's disease.


Methylphenidate (Ritalin)-associated cataract and glaucoma.


This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.


Dyskinesias induced by subthalamotomy in Parkinson's disease are unresponsive to amantadine.


A unique case of transient, profound paralysis after epidural steroid injection is reported here.


The proband had no detectable DPD activity.


The amounts of total brompheniramine, dextromethorphan, and pseudoephedrine remaining in the baby bottle were 1.4 mg, 9.4 mg, and 40 mg, respectively.


We present a case report of a patient with alveolar hydatid disease, whose treatment with mebendazole was brief due to side effects of alopecia and granulocytopenia; and review the features of this disease which, with increasing international migration, may be encountered more frequently in Australia.


PURPOSE: To report spectral domain optical coherence tomography (OCT) and angiographic findings in exudative retinal detachment complicating central serous chorioretinopathy.


METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.


BACKGROUND: The number of leishmaniasis cases associated with immunosuppression has increased regularly over the past 20 years.


Temozolomide is a relatively new chemotherapeutic agent frequently associated with selective CD4+ T-lymphocytopenia.


CONCLUSIONS: ECT was an effective local treatment in the majority of nodules treated.


Exposure to mercury vapour produced in operating rooms is the main concern for dentists.


Detection and treatment of Strongyloides hyperinfection syndrome following lung transplantation.


A 7-year-old boy with T cell acute lymphoblastic leukemia developed disseminated hyalohyphomycosis due to Fusarium solani.


The patient was left untreated and died 5 months after this diagnosis was made, of a second malignancy.


Generalized argyria after habitual use of AgNO3.


A 27-year-old Caucasian woman with end-stage Crohn's disease was hospitalized with an upper extremity thrombosis.


She recovered spontaneously within several days, making transplantation unnecessary.


The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.


We report here the case of an immunocompetent 3(1/2)-year-old girl who developed encephalitis and herpes zoster opthalmicus 20 months after her immunization with varicella-zoster virus vaccine.


We describe a patient in whom this was the primary manifestation of drug hypersensitivity.


OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.


PURPOSE: Interface inflammation is a common complication of laser in situ keratomileusis (LASIK).


Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.


Posthypoglycemic hyperglycemia (rebound hyperglycemia) after overdosing of insulin was diagnosed in 6 cats with diabetes mellitus.


This symptom gradually abated within a week and when the dosage of milnacipran was increased to 100 mg day(-1) at 2 months, no further piloerection occurred.


Acute pancreatitis associated with high-concentration lipid emulsion during total parenteral nutrition therapy for Crohn's disease.


Immune reconstitution inflammatory syndrome (IRIS) is a recently described entity in which severely immunodepressed HIV patients, after being started on HAART, develop inflammatory reactions to several pathogens.


Gemcitabine-related radiation recall preferentially involves internal tissue and organs.


The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.


Although the source and timing of HBV exposure remain unclear, the potential for severe hepatitis B infection following bone marrow transplant warrants caution.


Trimethoprim-sulfamethoxazole-induced aseptic meningitis.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.


We believe serum triglyceride levels should be monitored in patients who have other cardiac risk factors and are receiving clozapine.


Myelodysplasia syndrome (MDS) presenting as spontaneous gingival hemorrhage is described.


The mechanisms of methotrexate toxicity remain unclear, and no effective treatment exists to prevent its occurrence.


His fever resolved, but he developed symptoms consistent with those of chloroquine toxicity.


Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.


For therapeutic drug monitoring (TDM), blood samples were collected on day 1.


Hence, abrupt discontinuation of antimuscarinics or anticholinergics with high antimuscarinic properties in patients receiving long-term acetylcholinesterase inhibition therapy may be associated with a reduction of seizure threshold.


Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.


A 69-year-old woman developed Cushing's syndrome after long-term use of Sinatren, an Indonesian over the-counter drug, which was pharmacologically analysed three times before the correct content was discovered.


We present the first case of GVO-complicated pyogenic portosplenic vein thrombosis which led to persistent Klebsiella pneumoniae septicemia.


METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.


TB should always be considered as a possible diagnosis when treating febrile immunocompromised patients.


Although it is generally well tolerated, liver toxicity has been recognised as a complication of long-term use.


CONCLUSIONS: The most rational approach to treating NMS entails a hierarchy of interventions determined by the severity and progression of symptoms.


Oral and topical forms of psoralen-containing drugs are routinely used in medicine.


The first case concerns a 70-year-old man who developed severe aplastic anemia 7 weeks after treatment with 500 mg of ticlopidine daily.


He is in remission of AML and tuberculosis.


The majority of the induced lesions is in the distal ileum, sigmoid colon, or rectum.


Two patients were found to have a positive ANA at low titers, 1 of whom had histopathologic evidence of stratum malgiphian necrosis with perivascular lymphocytic infiltration on skin biopsy.


We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.


Adenocarcinoma of the pancreas developed in a young man who was a 10-year survivor of acute myeloblastic leukemia (AML).


Treatment was stopped after 2 weeks.


The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.


Cutaneous necrosis after injection of polyethylene glycol-modified interferon alfa.


Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.


Laboratory tests revealed cyclosporine nephrotoxicity, cytomegalovirus infection, and prediabetes.


Cases include typical and unusual presentations of the syndrome, and commonly encountered problems and pitfalls of therapy.


He was treated and monitored over the subsequent several months.


In three patients, involuntary movements emerged during the course of treatment and in the others only after discontinuation of the drug.


This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.


Serotonin reuptake inhibitors, epilepsy and myoclonus.


CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.


KS is a rare complication in glomerular diseases that may (or may not) be related to immunosuppression.


We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.


METHODS: Seven young children with RMS were treated from January 1990 through September 1991 with multiagent chemotherapy, organ preserving surgery, and HDR.


Discontinuation of procainamide led to complete recovery.


We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.


Report of a case and review of the literature.


METHODS: References for this review were identified by searches of PubMed from 1980 until January 2008 with the terms "Parkinson disease," "impulse control," "pathologic gambling,""hypersexuality," "levodopa," and "dopamine agonists." Articles were also identified through searches of the authors' own files.


Linearity was observed up to 2.0 mg/L.


However, the increasing dose intensity has not significantly improved the event-free survival.


A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.


Atypical antipsychotic induced mild hypothermia.


The inferior alveolar nerve (IAN) contains mainly sensory fibers.


Two months before admission, MVI was discontinued in the TPN because of the shortage of its supply.


Nine patients were granulocytopenic; the three additional patients with normal granulocyte counts were immunosuppressed.


In 7 CVC-related infections (35%) the catheter was removed.


Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.


A decreased Arden ratio on EOG (<1.50) was found with an accompanying decreased amplitude of the scotopic b-wave on full-field electroretinography in both eyes.


Transient postoperative pericardial constriction in a child.


After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.


Infusion of fresh frozen plasma together with aspirin and dipyridamole resulted in recovery of microangiopathic hemolytic anemia and thrombocytopenia.


Suxamethonium apnoea terminated with commercial serumcholinesterase.


Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.


Nitrendipine is an experimental calcium channel blocking agent that also appears to cause the side effect of drug-induced gingival hyperplasia.


Nevirapine is a non-nucleoside reverse transcriptase inhibitor used in the treatment of human immunodeficiency virus (HIV)-infected patients and in post-exposure prophylaxis.


A number of drugs have been reported to cause neuromuscular blockade and/or to increase weakness in myasthenia gravis.


Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.


Renal insufficiency, however, persisted.


Disseminated tuberculosis following second unrelated cord blood transplantation for acute myelogenous leukemia.


In view of the potentially fatal hypersensitivity reaction, we suggest that any patient on multidrug therapy for leprosy needs an urgent referral to a dermatologist if the patient develops a skin rash during the first two months of treatment.


We present clinical data, neuropsychological findings, and results of brain computed tomography or magnetic resonance imaging, electroneuromyography, evoked potentials, single photon emission computed tomography, and positron-emission tomography.


This abdomen CT scan was thought as abnormality pictures of neutropenic enterocolitis.


BACKGROUND: Hydroxyurea is a cytostatic agent used to treat myeloproliferative disorders and long-term treatment is associated with mucocutaneous adverse events and nail hyperpigmentation.


One was alive with no evidence of disease at 14 month follow-up, while 2 had residual disease after bone marrow transplantation and died of complications at 4 and 5 months after transplantation.


Erythema multiforme bullosum due to rifampicin.


A corneal and external disease specialist performed a complete ophthalmologic exam and obtained medical histories of the patients.


Drug induced suicidal ideation.


Tap (draft) beer and monoamine oxidase inhibitor dietary restrictions.


CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.


Cisapride for the treatment of nausea produced by selective serotonin reuptake inhibitors.


Sodium nitroprusside was stopped and amrinone 100 mg bolus followed by 10 micrograms.kg-1.min-1 was given in addition to adding PEEP to the ventilation.


However, the effect of chemotherapy on cord tolerance is unclear.


Clinically important side effects are infrequent, but diarrhea, usually transient, occurred in about 13 percent, with frank steatorrhea in 2 to 6 percent of cases.


We report a case of DCL that developed in the context of the immune reconstitution inflammatory syndrome (IRIS) in a man with AIDS following initiation of antiretroviral therapy.


Vitamin B12 (cyanocobalamin) is an integral component of two biochemical reactions in man: the conversion of L-methylmalonyl coenzyme A into succinyl coenzyme A and the formation of methionine by methylation of homocysteine.


During the first post-treatment days, diffuse lamellar keratitis (DLK) (stage III) developed.


Methanol poisoning in Tunisia: report of 16 cases.


We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.


This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.


Exposure of the fetus to indomethacin by administration of the drug to the mother may cause many side effects, including premature closure of the ductus arteriosus.


Myoglobinuria is a recognised complication of Duchenne muscular dystrophy (DMD), but has only once been reported in ambulant boys on corticosteroid therapy [Dubowitz V, Kinali M, Main M, Mercuri E, Muntoni F.


He had a 1-year history of mechanical aortic valve replacement and coronary stent placement because of myocardial infarction and he was taking warfarin and clopidogrel.


Necropsy findings indicated that the pancreatic adenocarcinoma had metastasized to surrounding tissues and vessels, which was not unexpected given the high grade assigned to the neoplasm during histologic analysis.


Visual acuity improved from finger counting or less to 20/40 or better in all cases.


High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.


It is presumed that her hyperchloremic metabolic acidosis was secondary to cholestyramine because of the similarity to pediatric reports; the rapid and lasting response to intravenous sodium bicarbonate; the absence of another etiology; normal serum potassium, chloride and bicarbonate despite continued spironolactone therapy after recovery.


A 31-year-old man intermittently received 2.5 x 10(8) units of alpha-IFN and 1 x 10(8) units of beta-IFN for treatment of chronic viral hepatitis type B.


This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.


HBsAg seroconversion was achieved after an additional 12 months.


Five days after the 3rd booster dose, in November 1996, the dermatosis relapsed on the forearms, trunk, and legs.


Serum glutathione levels were assessed in a patient with genetically proven Unverricht-Lundborg disease (ULD) before and during treatment with the antioxidant N-acetylcysteine (NAC).


The reaction subsided after treatment with diphenhydramine and dexamethasone.


We report a case of IDDM which occurred during interferon therapy for chronic hepatitis.


Clonal cytogenetic evolution was evident in 2 of the 3 patients and included an extra Philadelphia chromosome in both.


We report a patient with linear IgA bullous dermatosis and gluten-sensitive enteropathy.


These patients were treated with cholinesterase inhibitors within a post-marketing surveillance study.


Peritonsillar bupivacaine infiltration, a relatively safe method of pain control, is in some centers frequently used by otolaryngologists for pain relief.


Iatrogenic Mycobacterium infection after an epidural injection.


A 74-year old white man was undergoing treatment with palliative chemotherapy for Stage IV Prostate Adenocarcinoma with multiple osteoblastic metastases.


We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.


Before transfer from the emergency room, she was found to have an elevated serum urea nitrogen and creatinine of 55 and 5.8 mg/dL (19.6 mmol/L and 512.7 micromol/L, respectively).


We present a unique case of GTBM in a patient with myeloma following treatment with Melphalan.


Cutaneous lesions were pleomorphic but the typical picture of ecthyma gangrenosum was common in this group of patients.


The 3-week sulphasalazine syndrome strikes again.


A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.


Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma.


Tularemia--an unusual cause of a solitary pulmonary nodule in the post-transplant setting.


Data suggest that tamoxifen is involved in the pathogenesis.


We report a 76-year-old man who developed an acute blistering eruption following high-dose penicillin treatment for pneumococcal septicaemia.


We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.


Agranulocytosis during clozapine therapy.


Our results suggest that HCQ slow oral desensitization is safe, effective, and easy to perform.


Immunological mechanisms are suggested in the pathogenesis of psoriasis and ulcerative colitis.


Edema disappeared two to three days after stopping therapy but reappeared in all five patients after being reexposed to the drugs.


OBJECTIVE: To report a case of Jarisch-Herxheimer reaction (JHR) in a patient with presumed neurosyphilis and HIV.


One month after changing to fosinopril therapy, the patient reported complete resolution of the cough.


This entity may considered in the differential diagnosis of acute onset of colicky abdominal pain in the patient given narcotics.


Caution should be taken when designing estrogen-related experiments involving Brown Norway rats and other potentially sensitive strains.


Biomicroscopy revealed amiodarone corneal deposits.


A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.


While this could be a chance association, it does raise the question if her neurologic manifestations could be secondary to scleromyxedema.


Sensitization remained demonstrable 2 months after cessation of the former drug.


Conservative lithium administration is recommended for acute manic psychosis and reference is made to the beneficial effects of urea and aminophylline on renal lithium elimination in the active treatment of lithium poisoning.


The remission of nephrotic syndrome after treatment of Strongyloides infection strongly suggests the possibility of Strongyloides-associated glomerulonephritis.


Here, we report a 73-year-old male hydrocephalic patient who had undergone uneventful V-P shunt surgery 9 years ago.


Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.


Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).


Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.


There has been mild improvement of her symptoms, but most of the symptoms did not resolve.


The patient underwent bilateral vertebral stenting due to severe stenosis in both intracranial segments of the vertebral arteries.


As compared with an expected number of 0.04 cases of acute myeloblastic leukemia based on patient-years, the observed seven cases correspond to a 175-times increased risk.


A complete clinical remission of the lymphadenopathy was obtained after infusions of rituximab (an anti-CD20 monoclonal antibody), acyclovir, and high-titer anticytomegalovirus immunoglobulin.


Routine microbiological tests were negative.


Three URTI and one associated upper and LRTI were diagnosed in three BMT recipients out of six patients admitted to the BMT unit, during eight-wk period (March and April 2008).


High-dose tamoxifen was recently reported as a novel treatment for patients with malignant gliomas who have failed standard therapies.


Disease behaviour in two patients was classified as penetrating because of concomitant ischiorectal abscesses, while one patient developed a metastatic colon carcinoma.


Coexistent psoriasis and lupus erythematosus treated with alefacept.


The computer-based algebraic method is illustrated for a problem previously analyzed by Monte Carlo simulation.


The patient subsequently developed severe ischemic necrosis of the skin and soft tissue surrounding the catheter site.


PURPOSE: To report a case of angiographically documented cystoid macula edema occurring after switching a pseudophakic patient from latanoprost to bimatoprost.


She had previously taken simvastatin which is metabolized by CYP3A4, without any sign and symptoms of rhabdomyolysis.


The therapeutic significance of increased Hb F levels in homozygous beta thalassemia and sickle cell anemia is exemplified.


A spectrum of diseases.


We describe a patient who experienced chronic nausea and an episode of confusion while treated with a small, stable dose of oral morphine in the setting of mild renal insufficiency.


CONCLUSIONS: Clinical pharmacists and other healthcare professionals should remain cognizant of possible product quality differences within or bioequivalency differences between levothyroxine products.


The results suggest that the development of severe hypocalcemia can be explained on the basis of hypoparathyroidism in relation to hyperphosphatemia, hypomagnesemia, and acute renal failure.


Doxycycline-induced photo-onycholysis.


At such a time, the poor respiratory function makes some diagnostic procedures harmful.


This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.


Diffuse pulmonary uptake of indium-111-labeled leukocytes in drug-induced pneumonitis.


Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.


Electromyelography confirmed peripheral nerve injuries.


In one case, the patient was successfully treated by orthotopic cardiac transplantation.


Mycobacterium marinum infection complicating Crohn's disease, treated with infliximab.


Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia.


Immune reconstitution syndrome following initiation of antiretroviral therapy in a patient with HIV infection and multidrug-resistant tuberculosis.


Intravenous were started and a below knee amputation date of admission under spinal anaesthesia.


Local aprotinin injections are used in the treatment of chronic tendinopathy.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Long-term studies will be needed to demonstrate reversal of endocrine, hepatic and cardiac dysfunction secondary to iron deposition in these patients.


The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.


The encouraging result obtained warrants the use of this combined treatment modality in other patients.


To the best of our knowledge, this is the first report on the treatment of Stenotrophomonas maltophilia bacteremia after living donor liver transplantation.


We present a case of liver failure in a haemophilic patient coinfected with transfusion acquired human immunodeficiency (HIV) and hepatitis C (HCV) viruses.


The major contraindication to the use of intravenous verapamil is recent administration of intravenous beta-blocking agents (i.e., within the past two hours).


In one 12-month period he had 88 separate admissions to an emergency department with severe hypoglycaemic coma requiring intravenous glucose administration.


Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.


"I couldn't believe how tired I was without realizing it until after I finished a course of iron therapy.


Phototesting with ultraviolet B (UV-B) and ultraviolet A (UV-A) radiation revealed decreased minimal erythemal doses for one or both wave bands in all patients tested.


There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.


We recommended periodic examination of the serum proteins in patients receiving diphenylhydantoin in order to detect development of monoclonal gammopathy.


SUMMARY: A 65-year-old Caucasian man was admitted to the hospital on January 26, 2006, for worsening congestive heart failure (CHF).


We present a case of sotalol-induced bradycardia reversed by glucagon.


Hepatocellular carcinoma in a young woman with prolonged exposure to oral contraceptives.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Early surgical intervention, as well as appropriate antimicrobial therapy, is usually necessary.


The nonnucleoside analog nevirapine is an inducer of cytochrome P450 3A4 liver metabolism and has interactions with protease inhibitors and oral contraceptives.


Minor residual neurological signs remained.


To limit this problem, the clinician should decrease the amount of air injected in the epidural space or substitute nitrous oxide for air when injecting steroid agents epidurally.


The aetiology is currently unknown, and treatment difficult, with a poor response to antihistamines.


At postmortem examination, the characteristic microvascular lesions of the hemolytic-uremic syndrome were found in the kidneys.


A large number of eosinophils in AIA polyps were found before steroid treatment and at recurrence, and they were predominantly composed of activated eosinophils (EG2-positive).


Mycotic aneurysm of the descending thoracic aorta in a 2-kg neonate.


Because there were no other obvious causes of renal failure in either patient, we propose that skeletal muscle ischemia developed during vasopressin infusion, followed by release of myoglobin and renal damage.


Acanthamoeba keratitis associated with contact lenses: six consecutive cases of successful management.


A week prior, the patient was started on folic acid 1 mg orally daily and given an injection of vitamin B12 1000 microg intramuscularly that was continued every 3 cycles thereafter.


Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.


The third patient, treated with 0.5 cc of thrombin, had an uneventful postoperative course.


Benign intracranial hypertension occurred in four young women taking tetracycline for acne; two were also taking vitamin A.


I have described a patient with a prosthetic heart valve in whom the purple toes syndrome developed.


We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).


Glucose-6-phosphate dehydrogenase deficiency was present in the former case and was thought to contribute to the lung injury.


Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.


We conclude that treatment with ramipril can be employed effectively and safely in GSD Ia patients with nephrotic-range proteinuria.


Within 2 weeks after starting azithromycin, the patient's forced expiratory volume in 1 second increased significantly and a repeat spiral CT chest scan 5 months later, showed a major improvement of the bronchiectasis.


Urokinase treatment of neonatal aortoiliac thrombosis caused by umbilical artery catheterization: a case report.


Successful treatment of ventricular assist device associated ventricular thrombus with systemic tenecteplase.


He responded favorably to hemodialysis.


The patient developed pulmonary hypertension without a prior diagnosed cardiac and/or pulmonary disease.


CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.


Acute renal failure with severe tubulointerstitial changes in a patient with minimal change nephrotic syndrome treated with enalapril.


This case illustrates the importance of dermatological manifestations of systemic disease as an accessible source for diagnosis and guidance in appropriate therapy.


In the two cases, a combination of iloprost, a stable prostacyclin analogue (1 to 2 ng/kg/mn) with aspirin and dipyridamole was shown to inhibit ex vivo the heparin-induced platelet aggregation.


The median serum lead was 2.5 micro mol/L (range 1.38-4.83).


After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.


The patients evidenced improvement with olanzapine that equated to 16- to 31-point decreases in rating scale scores during 1-year follow-up without any hematologic abnormalities.


Treatment with isotretinoin appeared to shorten her recovery period.


However, the magnitude of such false positivity has not been previously reported.


A renal biopsy specimen on hospital day 9 showed tubular damage with minimal glomerular changes consistent with a diagnosis of nonsteroidal agent-induced nephropathy.


Both agents are excreted by the kidneys, raising the possibility that acyclovir at high serum concentrations may interfere with the renal excretion of lithium.


These observations confirm that ecthyma gangrenosum may be a primary cutaneous disorder not systematically associated with bacteremia.


Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain.


(2) In 8 out of 13 cases without recombinant human EPO treatment before PTX, a 10% increase in RBC was observed after PTX.


A lasting change in trazodone response after non-convulsive electroshock therapy for medication-resistant senile depression.


Mammary gigantism is a rare complication of D-penicillamine treatment.


Adrenal suppression in a fetus due to administration of methylprednisolone has hitherto been rarely published.


Three of the six had the OGC develop as a tardive side-effect, and in one patient the episodes persisted for some months after the cessation of the offending neuroleptic drug.


Post-transfusion purpura: response to steroids and association with red blood cell and lymphocytotoxic antibodies.


This case illustrates that posttransplant primary cutaneous CD30+ anaplastic large cell lymphomas may assume an aggressive clinical course but can still be controlled by systemic chemotherapy.


A woman 38-year-old, suffering for about ten years from multiple sclerosis and treated with repeated therapy cycles of intrathecal Depo-Medrol, developed a spastic paraparesis at the lower limbs.


Erections reported with other dopamine agonists and levodopa are probably mediated by the same mechanism.


Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.


He continued inhaled tobramycin 300 mg twice daily, his home doses of pancreatic replacement enzymes and vitamins, albuterol 2.5 mg by high flow nebulizer (HFN) 4 times daily, and dornase alpha 2.5 by HFN daily.


Jude total therapy studies XIII.


The relationship between this paraneoplastic endocrine syndrome and the clinical course of the tumor is examined in this review of patients with the ectopic ACTH syndrome and small cell carcinoma seen at The Johns Hopkins Oncology Center between 1973 and 1979.


Here, we describe levofloxacin-induced delirium with psychotic features in a relatively young, otherwise healthy female.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


With an increasing trend towards re-treating patients with known IIRs, clinicians should be aware of this potentially serious and previously unreported complication.


Both patients subsequently developed markedly elevated EBV-DNA titers in association with monoclonal, light chain-restricted B cell populations in the blood.


Routine serum chemistry and full blood cell count (apart from neutrophil count) were normal.


A 16-month-old male presented to the Emergency Department cyanotic and short of breath after ingestion of a hair-care-equipment cleaning solution.


Interferon-beta (IFN-beta) is a type I interferon used in the management of multiple sclerosis.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


The reaction to sodium sulfite in the next patch testing was negative.


Histological examination of the resected specimen demonstrated the strong affinity for Congo red and yellow-green birefringence that are characteristic of cerebral amyloid angiopathy.


Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.


CONCLUSION: Owing to the potential for increased toxicity, the combination of raltitrexed and mitomycin-C cannot be recommended as first-line treatment in patients with advanced colorectal cancer.


Such cells were present in far greater numbers than are usually seen in untreated patients with HS or patients with HS undergoing successful bone marrow transplantation without GM-CSF.


The course of a seasonal bipolar disorder influenced by caffeine.


They fear that beta-blockers will block adrenergic symptoms, and patients will not know when they are hypoglycemic.


Gonioscopy revealed the presence of a scleral abscess, which responded to subconjunctival injection of vancomycin and an intense and prolonged course of topical antibiotics.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


A case of severe visual loss following a single dose of vincristine is described.


Delayed immune reconstitution after SCT, such as cord blood and T-cell depleted SCT with the use of alemtuzumab, has been associated with an increased frequency of CMV disease as well as CMV reactivation.


Antidepressants and myoclonus: case report.


This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.


This trial was designed to evaluate intraarticular delivery of a tumor necrosis factor alpha (TNF-alpha) antagonist, through an adeno-associated virus (AAV) type 2 delivery system, for inflammatory arthritis.


Therapy consisted of 3 cycles of induction cisplatin/5-fluorouracil chemotherapy followed by radiotherapy.


Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.


However, clinical manifestations and treatment options have rarely been described in the pediatric literature.


Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.


These data confirm the therapeutic value of arsenic trioxide in relapsed/resistant APL.


These subjective sensory phenomena were not associated with sensory loss or autonomic or motor signs.


Spinal myoclonus resembling belly dance.


CASE: A patient was admitted to hospital with preterm contractions and cervical insufficiency at 28 weeks of gestation.


Immune-mediated hemolytic anemia is a well-recognized complication of hematopoietic stem cell transplantation.


We report a 4-year-old girl who presented with acute bilateral blindness, a focal seizure and hypertension 10 days after commencing oxybutynin to treat enuresis.


The case is presented of a 35-year-old woman with major thrombotic obstruction of a 29-mm St.


One month after that, sperm motility was vastly improved (65%) and they conceived a child 5 months after that.


Death from chemotherapy in gestational trophoblastic disease.


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.


This is a retrospective analysis of the complete autopsy records and clinical histories of 500 adults who underwent organ transplantation at the University of Pittsburgh Medical Center during the interval of March, 1981 through July, 1997.


Hypersensitivity reactions due to chloramphenicol are rarely reported in the literature.


This article considers treating patients in the first 2 years of rheumatoid arthritis with low dose of oral corticosteroids.


To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.


To our knowledge, no cases of glaucoma have been reported so far.


This is the first description of BRONJ involving the skull base.


The elderly are also particularly prone to develop toxic side effects from standard antidepressive agents.


A 31-year-old female was found to have FIGO Stage IIB squamous cell carcinoma of the cervix.


Although a surgical approach has been emphasized in patients with peripheral vein suppurative thrombophlebitis, anticoagulation therapy may be a useful alternative in the treatment of patients with central vein infection.


On admission, he presented with clinical features of chronic GVHD including transient exacerbation of cholestatic liver injury.


CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.


Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.


Well tolerated, midodrine appears to be a suitable and effective agent as it raises blood pressure significantly via its effect on peripheral alpha-adrenergic receptors.


Preoperative prophylaxis for C1 esterase-inhibitor deficiency in patients undergoing oral surgery: a report of three cases.


We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated interferon alfa-2b at different doses.


Six of the patients were no longer receiving vigabatrin.


Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.


Setting.


METHODS: We examined trends in Accutane use by reproductive-aged women.


Tolerance to cannabis was not reported.


On the 7th day, these values reached a maximum, i.e. 95 and 160% of the control, respectively.


Discontinuation of methicillin therapy and appropriate antibiotic treatment of endocarditis led to clinical improvement, emphasizing the need to promptly discontinue potential nephrotoxic agents when abnormalities in renal function appear.


Data are presented to show that atopic cataracts and steroid cataracts can be similar in appearance and cannot be distinguished from one another in many cases.


RESULTS: Symptomatic epiphora of the affected eyes was reduced after 2 weeks.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


We have found no reports describing a technique for making custom hand-made articulating spacers.


A  number of similarities, including the fact that both medications are 250-mg white tablets, with similar generic and brand names which are generically repackaged medications juxtaposed on the pharmacist's shelf, predispose to the inadvertent substitution of one medication for the other.


They were studied clinically and with a representative range of in vitro and in vivo tests of immune function.


This case report describes a very rare complication of S. aureus sepsis in a 62-year-old haemodialysis patient, namely a suprarenal aneurysm of the abdominal aorta.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Her immunoglobulins in serum were checked on PHT and after 15 years treatment with carbamazepine.


We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.


After stereotactic aspiration of the abscess, successful treatment was achieved by triple therapy with trimethoprim sulfamethoxazole (TMP/SMX), ceftriaxone and amikacin.


A 26-year-old HIV-seropositive Caucasian man with cryptococcal meningitis developed permanent bilateral blindness shortly after starting highly active antiretroviral treatment.


A syndrome of increased affect in response to risperidone among patients with schizophrenia.


An enucleation specimen was examined by light microscopy.


A 52-year-old woman suffered from chronic active hepatitis type C and was treated with a total of 456 x 10(6) units of IFN-alpha for 23 weeks.


In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.


The traditional treatment for melanoma recurrences on an extremity has been surgical excision or less often amputation.


Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin.


A self-expanding metallic stent (Wallstent) was used to relieve obstruction of the common bile duct in a young male with a desmoplastic small cell tumor of the abdomen.


The need for professional support for the carers of such patients should be recognized.


A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.


We report a case of a young woman with SLE and thrombocytopenia, who developed severe perspiration, headache, and seizure after receiving cyclosporine.


Systemic cyclosporin (10 mg/kg/day) resulted in resolution of the corneal ulceration within two weeks of beginning treatment, and the patient has remained in remission after 15 months of therapy.


Several reports have emphasized the need for a loading dose in order to achieve therapeutic blood levels rapidly.


Two cases of mequitazine-induced photosensitivity reactions.


Ischemic cholangitis caused by transcatheter hepatic arterial chemoembolization 10 months after resection of the extrahepatic bile duct.


Discontinuing the drug quickly resulted in disappearance of the dyspnea.


Shortly after a meal, symptoms are associated with hyperglycemia (early dumping), followed by late dumping symptoms associated with reactive hypoglycemia.


Cephalosporins are most likely associated with Vitamin K deficiency.


Arterial occlusive events during chemotherapy for germ cell cancer.


This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.


A fifty-five-year-old male patient underwent total laryngectomy, bilateral modified radical neck dissection, and primary voice restoration for squamous cell carcinoma of the supraglottic larynx.


These cases and others quoted indicate that dependence on pressurized aerosol bronchodilators can and does occur in young people.


SETTING: A neuro-ophthalmology referral center.


The daily infusion of IgG had to be suspended after three days in the second patient with encephalitis and nephritis, because the renal function rapidly deteriorated; subsequently, six plasma exchanges led to an almost complete recovery.


Remarkable findings on initial examination were facial grimacing, flexure posturing of both upper extremities, and 7-mm, reactive pupils.


Four patients were neutropenic (less than 500/microliters).


CASE REPORT: A 32-year-old man with lymphoblastic lymphoma received treatment with daunorubicin, vincristine, and prednisone.


RATIONALE: Taking psychotropic medications is frequently problematic from both consumers' and caregivers' perspective.


Therefore, ocular examination at baseline and every 6 months is indicated for patients receiving a regimen of amiodarone and/or digoxin therapy.


She was started on amlodipine 2.5 mg orally once daily, a nitroglycerin patch (0.4 mg/h), and warfarin 5 mg orally once daily.


In the mean-time the drug is available in Canada and England but not in the U.S.


A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.


INTERVENTIONS: Treatment with clonazepam.


He failed to improve when therapy was continued with low-molecular-weight (LMW) heparin (Fragmin, Kabi Pfrimmer, Erlangen, FRG).


All patients had previous mucocutaneous reactions to chrysotherapy.


Clinical and laboratory manifestations resolved after cessation of methysergide therapy.


The history of desmopressin use was not obtained at that time.


The clinical course of this patient did not support a cause-and-effect relationship between obidoxime and the abnormal liver function.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


Ventriculo-peritoneal shunting led to complete reversal of hydrocephalus with progressive disappearance of the acute encephalopathy.


Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication.


Bromide intoxication secondary to pyridostigmine bromide therapy.


One year later, a progressive increase in policlonal gamma-globulin and a decrease in the CD4+ lymphocyte count to below 500/muL were detected in concomitance with ultrasonographic evidence of a progressive increase in the longitudinal diameters of the liver and spleen and signs of liver inhomogeneity.


The patient showed no initial evidence of being a latent HBV carrier.


Physical examination revealed diaphoresis, low-grade fever, hypertension, tachycardia, bilateral cogwheel rigidity, hyperreflexia, tremor, and myoclonus, symptoms and signs that are consistent with severe SS.


A 54-year-old man received combination chemotherapy with nedaplatin and irinotecan as salvage chemotherapy for refractory non-seminomatous testicular cancer.


Three cases of acute renal toxicity in patients receiving long-term therapy with mitomycin C and 5-fluorouracil are reported.


Six years after treatment he had a progressive increase in the platelet count and was diagnosed as essential thrombocythemia.


A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen.


Intraoperative Healon5 injection into blebs for small conjunctival breaks created during trabeculectomy.


Intra-operatively, he suffered inadvertent injury to an intercostal arterial branch during isolation of the aorta below the graft.


There was no evidence of worsening of the myotonic symptoms.


Here, we report on six cases of NE in patients with acute leukemias.


Life-threatening hypokalaemia and quadriparesis in a patient with ureterosigmoidostomy.


Since their introduction in 2006, the tyrosine kinase inhibitors (TKI) Sunitinib and Sorafenib have become the standard of care for many patients with renal cancer.


We report a series of 16 cases of methanol poisoning admitted to our Intensive Care Unit between December 2003 and April 2004.


He had been abusing ergotamine compounds for several years on at least 15 days per month.


Protamine-induced fatal anaphylaxis.


Fulminant hepatic failure developed in a 24-year-old black woman who had been treated with propylthiouracil and propranolol for hyperthyroidism.


Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006).


He began taking propafenone only 6 days prior to admission because of uncontrolled atrial fibrillation and symptoms of fatigue.


This is a case of pseudoephedrine-induced intracerebral hemorrhage in a patient with an underlying vascular malformation.


Systemic complications associated with retinal cryoablation for retinopathy of prematurity.


Magnetic resonance imaging of the spinal cord disclosed signal-intensity abnormalities from C4 to C3.


Typically, it occurs in a patient with preexisting structural heart disease (20 of 24 [83%]) and often with some form of recent dental infection or manipulation (18 of 24 [75%]).


Two months after the operation in the right eye the patient presented with active infection in the left eye.


Consistent with the data in healthy volunteers, a major interaction between esomeprazole and atazanavir-ritonavir was observed in this patient-marked reductions in atazanavir trough plasma concentration and in the area under the concentration-time curve from 0-24 hours-whereas an interaction between esomeprazole and fosamprenavir-ritonavir was not apparent in this patient.


The patient presented with lethargy, abdominal pain, and vomiting.


A major advantage of genotyping compared with phenotyping is that the former may be performed in blood samples from patients irrespective of treatment.


CONCLUSION: Although intravenous corticosteroid treatment for uveitis associated with multiple sclerosis can be very helpful, the patient should be monitored closely for systemic side effects.


Hepatic adenomas are rare tumors; they have been associated with the use of anabolic steroids.


Remissions following treatment of individual lesions varied from one month to at least three years.


In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.


Her treatment was complicated by hypocalcemia and thrombocytopenia.


Recognized side effects include fatigue and constipation.


Additionally, we showed conclusively that under certain circumstances (that is, corneal scarring) tandem scanning confocal microscopy can resolve the double-walled structure of the Acanthamoeba ectocyst surrounding the endocyst.


NE occurred 7-10 days after the completion of chemotherapy, during the neutropenic phase.


We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.


These patients all suffered unnecessary morbidity or investigations.


This disease is caused by inherited defects of the insulin receptor and is lethal early in life.


CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.


She underwent emergent surgical valve replacement.


Late development of diabetes mellitus after interferon-alfa and ribavirin therapy for chronic hepatitis C: a case report.


One man who had acute urinary retention before treatment was subsequently able to void extremely well.


In contrast to other reports regarding disseminated M. genavense infection, the patient is still alive and well.


The clinical presentation mimicked a viral exanthema.


However, this class of drugs has been associated with tic exacerbations, thus limiting their utility in this patients subgroup.


All eyes had conjunctival congestion and mild to severe corneal edema with Descemet's folds.


Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.


Ciclosporin was administered, allowing corticosteroid therapy to be discontinued.


The recovery of the pneumococcal meningitis was complicated by severe neurological impairment.


A skin biopsy specimen revealed microscopic, sterile, neutrophilic abscesses.


Upon a chlorpromazine minimal effective dose reduction, target behaviors increased and dosage was returned to prior levels with the conclusion that chlorpromazine was controlling the target behaviors.


We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.


Phantom limb pain as a manifestation of paclitaxel neurotoxicity.


Shakuyaku-kanzo-to (SKT) is a traditional herbal medicine that is widely used for muscular cramp and abdominal pain.


The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.


A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities, developed gradual stiffness and weakness of the lower extremities.


A 37-year-old woman with relapsing invasive vertebral aspergillosis received intravenous VRC and developed angio-oedema 10 days after starting therapy.


We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.


A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.


When using local anaesthetic epidural infusions, it is important to exclude other causes of motor block before attributing it to the local anaesthetic.


A patient with Wegener's granulomatosis rapidly developed a circumferential subglottic stenosis while on a cyclophosphamide regimen that had caused resolution of systemic symptoms and pulmonary infiltrates.


High-dose cytosine arabinoside may benefit patients with refractory acute leukemia.


A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.


Two cases of pneumococcal sepsis, meningitis and unilateral endophthalmitis after total splenectomy are described.


We present a rare case of retinoid-induced sclerotic changes of lumbar spine and femur demonstrated by dual energy x-ray absorptiometrie (DEXA).


Patient 1 presented bilateral ballism 1 week after intravenous heroin injection.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


A patient with chest pain was found to have obstructive hypertrophic cardiomyopathy.


We present a case of thrombosis of the right internal jugular vein presenting as a neck lump to the ENT department.


Neither the prior history of psychiatric illness nor brain damage predisposed to such response on treatment, and in most patients, it was not a part of hypomania or a more diffuse psychiatric disturbance.


A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.


This case reminds physicians to correlate the ancillary study results with the patient's clinical presentation and stability.


The calculated index (posterior tibial/arm pressure) increased from a mean of 0.22 to 0.74 during the eight-month period following discontinuance of methysergide therapy with no recurrence of migraine headaches.


Fulminant Pneumocystis carinii pneumonia in 4 patients with dermatomyositis.


However, the evidence is limited and studies have not assessed the outcome of a direct substitution in these cyclosporine-dependent patients.


Parenteral-verapamil-induced sustained hypotension.


A case of recurrent Candida parapsilosis prosthetic valve endocarditis: cure by medical treatment alone.


Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


The cause of the death was Myelodysplastic syndrome.


Treatment of high-dose intrathecal morphine overdose.


Implicated triggering factors are numerous and include toxins, medications, and infectious agents.


Diagnosis is made by clinical suspicion and exclusion of other causes of respiratory compromise.


She had undergone oral sex steroid therapy for long-term oligomenorrhea.


This report presents a 35-year-old woman in whom an intrathecal pump system was inserted for cancer pain management with intrathecal morphine.


After discontinuance of infliximab infusions and treatment of symptoms with intermittent courses of prednisone, the patient's arthritis progressively improved, with accompanying decrements in autoantibody titers.


At presentation, all patients were presumed to have classic DLK and were treated initially with aggressive topical steroids.


Mantle cell, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia were diagnosed 1-5 years after PEG-rHuMGDF exposure among three volunteers.


Drug-induced ocular pemphigoid has been reported to occur after long-term use of topical glaucoma medications.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


Fifteen such patients were treated with clozapine and rerated blind to baseline symptomatology and functional level from 2 to 9 months after beginning treatment (mean = 4.2 +/- 2.1).


The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.


The only residual neuroblastoma tissue visible on MIBG scintigraphy on day 150 of treatment was a metastasis in the left tibia which was irradiated with 24 Gy.


The next day similar symptoms developed with rechallenge of the same brand of sustained-release verapamil in a 120-mg formulation, and verapamil was discontinued.


During the past decade, NTX has been shown to be safe and effective in the treatment of pruritus associated with severe jaundice caused by severe and sometimes life-threatening cirrhosis and other liver diseases.


Adding low-dose antidepressants to interferon alpha treatment for chronic hepatitis C improved psychiatric tolerability in a patient with schizoaffective psychosis.


We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.


Hereditary angio-oedema is rare and potentially life-threatening, being characterised by recurrent episodes of perioral or laryngeal oedema.


Subsequently, she developed bilateral persistent corneal epithelial defects, epithelial edema, and bullae that failed to heal with bandage contact lens and topical lubricants.


A case report and review of the literature.


Acute leukaemia during tamoxifen therapy.


Human immunodeficiency virus-1 viral load and antibodies were also negative.


The most common therapeutic intervention was supportive care alone (48% of patients).


Surgeons and physicians should therefore be aware of the potential for RTA to occur with FK506 after any organ transplantation.


He was treated as a case of sympathetically mediated chest pain, pain modulators, analgesics and Stellate ganglion block.


MATERIALS AND METHODS: We describe a patient who sustained a parotid duct injury after Mohs micrographic surgery for treatment of squamous cell carcinoma.


It would therefore seem prudent to monitor red and white blood cell counts in patients taking MMF.


Negligible reactivity was observed with microsomes from human B-lymphoblastoid cell lines expressing CYP1A1, 1A2, 2A6, 2D6, 2E1, 3A4 or epoxide hydrolase.


The case of a 37-year-old obese man, who rapidly developed features of this syndrome after an antecedent pharyngitis and cellulitis, is presented.


He began treatment with dopamine agonists bromocriptine mesylate (in 1984) and pergolide mesylate (in 1989).


RESULTS: The cases described constitute a drug-induced lupus-like syndrome.


We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.


Biophysiological effects of Ukrain therapy in a patient with breast cancer (case report).


This case and the brief review of the literature which follows emphasize the danger of prednisone administration in patients who have asthma and a history of drug intolerance.


On CT, they were manifested as a peritoneal mass or thickening with variable shapes, including oval, round, bizarre, linear and even a molded shape due to where they were lodged, such as the pelvis and paracolic gutter.


Angioedema is more common in females and in the third decade of life.


RD is not a rare condition, but is often misdiagnosed and is potentially lethal.


Few published human data are available concerning the acute toxicity of the new antiepileptic drug oxcarbazepine of which the metabolite 10- monohydroxy derivate (MHD) is the pharmacologically effective compound.


One patient died shortly after this, whereas the second patient died of the complications of prolonged shock.


The patient had diabetic nephropathy with accompanying nephrotic syndrome.


Neurological improvement and rehabilitation potential following toxic myelopathy due to intrathecal injection of doxorubicin.


There is potential for this side effect, and additional caution in the use of this drug should be followed.


The authors suggest that serum sodium levels be carried out before commencement of carbamazepine and caution be used in prescribing carbamazepine to patients with low or borderline low sodium values.


Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.


Proctoscopic examination after 10 days of therapy showed marked improvement with no evidence of pseudomembranous exudate.


The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.


In the double-blind trial, 1 patient (12.5%) receiving rhEPO responded, as compared with no responses in the placebo group.


Clinical, laboratory, serologic, and histologic data of all three cases were analyzed.


Cardiac transplantation under new legislation for organ transplantation in Japan: report of two cases.


Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C.


Serum antidiuretic hormone (ADH) remained elevated at 0.59 pg/ml in spite of a significant reduction in serum osmolality to 254 mosm/kg.


One year after undergoing allogenic peripheral blood stem cell transplantation (PBSCT), this patient presented with proteinuria.


Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.


Reported here is an unusual case of radiation enteritis which caused a severe sequelae of stricture in the transverse colon as a long-term effect of therapeutic irradiation for uterine cancer, and required a surgical resection.


Body temperature was reduced to 26 degrees C and rhabdomyolysis due to hypothermia was observed.


Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.


The histology of these lesions is characterized by intravascular thrombi.


We report a case in which transient sinus arrest was observed under general anesthesia.


Ballistic movements due to ischemic infarcts after intravenous heroin overdose: report of two cases.


Neurotoxicity of valacyclovir in peritoneal dialysis: a pharmacokinetic study.


He was treated with intravenous antibiotics for 6 weeks with continuation of his immunosuppression.


It may vary in both presenting characteristics and severity.


We report here the case of a 36-year-old man with pre-B cell acute lymphoblastic leukemia.


Five of these six patients had renal failure.


Recent data in animal studies have indicated that olanzapine and clozapine rapidly impair whole-body insulin sensitivity in a dose-dependent manner.


Use of heliox for intraoperative bronchospasm: a case report.


Lenalidomide is an important contemporary treatment option for patients with multiple myeloma (MM).


The uneventful recovery seen in these patients shows the advances made in transplant medicine, including the progress and improvement of immunosuppressive therapy, surgical techniques, myocardial protection, and detection and treatment of infection.


Persistent ileus was treated with repeated doses of neostigmine, and gastrointestinal motility returned with prompt defecation.


The authors intend to carry out a case-control study on patients treated with tamoxifen for breast carcinoma to reveal the possible presence of endometrial carcinoma.


METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.


RESULTS-A gross mass of hyperplasia tissue found primarily in the left side of her mouth had disappeared and serum IgA which was subnormal at the first visit had normalized.


Diagnosis of pseudotumor cerebri was based on satisfaction of four criteria proposed by Ahlskog and O'Neill.


Immunohistochemical analysis of tongue biopsies confirmed the suspicion of melanin deposits in these areas of hyperpigmentation.


Possible mechanisms for this observation and clinical guidelines to identify patients at risk are suggested.


The diffuse use of cholinesterase inhibitors in the treatment of dementia may cause an increasing number of Pisa syndrome cases.


During his evaluation for right upper quadrant pain an abnormal liver scan demonstrated what proved to be a hypervascular hepatic lesion.


The uncomplicated long-term use of adequately-dosed AZA and stable non-toxic metabolite levels could not acknowledge TPMT deficiency as a primary cause of the leukopenia.


Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.


METHODS: A patient with C6D tetraplegia who sustained intoxication because of drug interaction is presented.


CONCLUSIONS: PRES is a rare syndrome that must be suspected in every patient presenting neurologic symptoms in the course of immunosuppression.


The following case demonstrates marked improvement in treatment-resistant RSD pain with intramuscular ketorolac.


Virilizing adrenal tumor in a child suppressed with dexamethasone for three years.


BACKGROUND: Drug toxicological screening is commonly used as a diagnostic tool in patients with suspected toxic ingestion.


S-1 could be used as palliative treatment in patients with recurrent/metastatic head and neck cancer.


Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.


No adverse effects attributable to therapy were identified.


It is a dibenzothiazepine derivative and shows similarities with clozapine in that it is characterized by high 5-HT(2)-relative-to-DA(2) receptor affinity.


Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.


Documentation of adverse events for safe and commonly used drugs is important.


After 4 weeks, the necrotic tissue sloughed off, the early signs of healing appeared making surgical debridement possible.


We report here on two middle-aged women, apparently healthy, who suffered from a fatal intracerebral hemorrhage following a dental treatment.


No recurrence of clinical signs occurred during the follow-up period (1 and 4 years, respectively).


A diagnosis of neuroleptic malignant syndrome was made and the patient continued to receive aggressive supportive care.


Growth hormone insufficiency in a girl with the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.


In the present study, arsenic trioxide was given intravenously for 42 days to a 56-year-old female patient suffering from chemotherapy/ATRA-resistant APL, with 43% APL blasts in the bone marrow and elevated D-dimers.


Once ACAD has been established, treatments such as coronary angioplasty, coronary stenting, and coronary bypass are performed.


The authors discuss the potential synergistic effects of these drugs and recommend treatment with propranolol.


Free SDCs were obtained using an ultrafiltration and fluorescence polarization immunoassay system in three patients over periods of up to 204 hours after Fab administration.


Thrombosis of prosthetic cardiac valves is a rare but potentially lethal complication.


Re-do surgery remains indicated for all other cases of prosthetic malfunction.


Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.


Leprechaunism is an autosomal recessive disease characterized by elfin-like faces, loss of glucose homeostasis, and severe insulin resistance.


Cosmetic permanent fillers for soft tissue augmentation: a new contraindication for interferon therapies.


No neurological deficit was detected despite prolonged hypoxemia.


On the other hand, CLL could precede, but could also be diagnosed at the same, or delayed time as AML, suggesting the presence of other leukemogenic factors.


A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.


The expected number of AML/MDS developing in a general population of the same size was 1.2 as calculated from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program data (observed-to-expected ratio = 2.49; 95% confidence interval = 0.9-7.3; p = 0.12).


To the best of our knowledge, this is the first case report of pelvic dyskinesia with good evolution and control of dyskinesias after treatment with tetrabenazine.


He was treated by the administration of vancomycin, fluconazole, and pazufloxacin mesilate.


Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.


A case is described of a life threatening vasculitis of the small bowel leading to massive gastrointestinal haemorrhage which was apparently due to cytomegalovirus inclusion disease.


We also discuss (in the format of questions and answers) the pathophysiological mechanisms underlying the association of serum uric acid with cardiovascular disease, and we review the relevant literature to justify an evidence-based decision to choose an antihypetensive agent (losartan) or a lipid-lowering drug (fenofibrate) with an additional hypouricaemic effect.


He has remained clinically stable for over 5 years.


We report a case of HCL in a 66-year-old male treated with 2-deoxycoformycin.


The patient was a 24-years-old male referred to the OPD Clinic at Zare Psychiatry Hospital in 2007 with symptoms of delusion of control, delusion of persecution, delusion of somatic and auditory hallucination, for the last year.


A diagnosis of severe lithium toxicity was made and the patient was admitted to the telemetry unit.


The treatment with leflunomide was suspended; the conditions of the patient gradually improved and he became completely asymptomatic 1 week later.


There is no case of acute bilateral parotitis reported previously with i.v. enalaprilat.


The clinical picture and radiological abnormalities disappeared spontaneously on discontinuation of the drug.


The onset of this endocrine syndrome appeared to coincide with a more aggressive phase of the course of small cell carcinoma.


Laparoscopic splenectomy was performed before therapy in four patients with platelet counts of <70,000/mm(3), and during therapy in five patients with severe thrombocytopenia.


BACKGROUND: Sympathomimetic-related intracerebral hemorrhage is well-documented.


CASE REPORT: Forty years oriented old male, opium addict, was admitted to the ICU, with headache, nausea and abdominal pain, and weakness in his lower and upper extremities without definitive diagnosis.


However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.


A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.


We confirmed FH deficiency in a 30-month-old boy with recurrent HUS of 2 years duration, and attempted an auxiliary partial orthotopic liver transplantation (APOLT) to overcome the sustained intractable dependency on plasma therapy.


The diagnosis was made by isolation of the organism only after surgical drainage was established and appropriate tissues were cultured.


Clinical trials have shown that atypical drugs such as sertindole do not induce EPS, are effective against negative as well as positive symptoms and do not affect cognition.


CONCLUSION: The administration of tissue plasminogen activator was responsible for the large extent of hemorrhage and should be considered in the differential diagnosis of hemorrhagic choroidal detachment.


HIV1 and HIV2 serology was negative.


We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.


The scavenging properties of N-AC may palliate and possibly prevent free radical-mediated liver damage.


A young male presented with acute cervico-facial swelling and loss of consciousness, following ingestion of barracuda flesh.


No respiratory symptoms appeared in the ten patients who were given less than 950 mg/m2.


Various probe drugs may be used for phenotyping CYP2D6 (debrisoquine, dextromethorphan and sparteine) and CYP2C19 (mephenytoin and omeprazole).


The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.


CONCLUSIONS: Early recognition of this serious pharmacogenetic syndrome may allow for the modification of future chemotherapy, thus avoiding further life-threatening toxicities.


His illness was also characterized by a palpable spleen tip, marked lower extremity and scrotal edema, and generalized lymphadenopathy.


This case of embolism into bone due to GEE is a rare complication which indisputably establishes a link between the spontaneously septic cavity of the bowel and bone tissue by way of blood via the interstices of the fabric.


The anti-epileptic agent trimethadione was given orally to 30 outpatients at a dose of 0.9-1.5 g daily.


Following diagnostic laparotomy she received intra-arterial 'lipiodolized' chemotherapy.


This procedure appears to be a simple, safe, and effective method for closure of a small conjunctival break.


In addition to the chemotherapy, other factors known to be capable of producing RML, such as sepsis, other medications, and dehydration were found.


A 32-year-old primigravida was admitted because of premature labor at 31 weeks of gestation.


Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation.


He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.


BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.