The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen.


We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.


CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.


In one patient there was resolution of symptoms following cessation of ketamine, but some symptoms persisted until death in the other two.


METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.


In three patients Westergren sedimentation rate decreased for up to five months after exchanges.


Though a considerable number of such lesions are cutaneous in origin, melanoma has rarely been reported.


Studies with a plant fungicide, imazalil, with vapor-phase activity, in the therapy of human alternariosis.


Successful management was made possible by a new somatostatin analogue (Vapreotide), administered i.m. at weekly intervals.


A 66-year-old man with hepatic metastases from gastric adenocarcinoma was treated on two occasions with 5-fluoro-2-deoxyuridine (FUdR) via hepatic artery infusion (HAI).


Thus, the eosinophilia myalgia syndrome can be associated with parenteral tryptophan administration.


NMS is a drug-related response to various medications, such as Haloperidol, which the patient was receiving.


In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.


Cerebral manifestations of ergotism.


We report a case of severe respiratory failure due to gold salt toxicity in a patient suffering from rheumatoid arthritis requiring mechanical ventilation.


Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.


Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.


Unusual weight fluctuation under corticosteroid and psychotropic treatment.


In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.


For primary ventriculoperitoneal shunt insertion in infants and young children, the single-pass tunneling technique is safe and avoids one source of complications.


To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.


Single drug level measurements may therefore be of little diagnostic value.


We describe children and adolescents with chronic hematologic and oncologic diseases who exhibited drug-seeking behavior or anticholinergic symptoms with the use of diphenhydramine.


The technical images (abdominal CT, scintigraphic octreotide scan and renal arteriography) revealed the presence of a left adrenal pheochromocytoma and stenosis of the renal artery.


METHODS: Thirty-two patients with chronic hepatitis C were examined prospectively for changes in fundus findings while they were being treated with pegylated interferon and ribavirin.


He developed a cerebellar hemorrhage after repetitive pressing of the shunt reservoir.


There were gross functional lesions of the cardiovascular, renal, and neuromuscular systems with no structural abnormalities.


The coagulation disorders were treated with prothrombin complex concentrate 30 IU/kg IV and vitamin K1 10 mg IV, and values normalized within 36 hours.


RESEARCH DESIGN AND METHODS: An in vitro exploration of cytokine production by peripheral blood mononuclear cells (PBMC) from the reported case was performed and compared with the same explorations of PBMC from three nondiabetic subjects and three diabetic patients without lipoatrophic lesions.


When pulmonary thromboembolism occurs, early diagnosis by pulmonary blood flow scintigram and early thrombolytic and anticoagulative therapies are necessary.


Use of haloperidol infusions to control delirium in critically ill adults.


This property is similar to that of other lipophilic agents such as amiodarone, chloroquine, chlorpromazine, quinacrine, and suramin.


Our case presents some of the challenges involved with managing ocular toxicity of these cardiac drugs.


CONCLUSIONS: Although mirtazapine offers clinicians a combination of strong efficacy and good safety, we suggest bearing SS in mind when prescribing this drug, especially in frail, elderly patients with underlying chronic conditions.


DESIGN: Case report.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


A 56-year-old male who was 12 months status post liver transplant presented with a 2-month history of painful, erythematous nodules over the right knee.


We propose that patients being treated with curative intent receive full-dose intensity, using body surface area calculated on actual body weight or on ideal body weight with dose escalations if tolerated.


Acute coronary syndromes can be associated with the infusion of rituximab.


Although bacterial keratitis occurs rarely after refractive surgery, patients should be informed of the potential risk for visual loss caused by this infection.


Despite therapeutic drug monitoring and subsequent efavirenz dosage reductions, side-effects did not resolve completely and lopinavir concentrations remained relatively low.


A 22-year-old man presented with hematuria and was found to have a mass in his urinary bladder on computed tomography.


We present a case of the syndrome of inappropriate antidiuretic hormone (SIADH) secondary to cisplatin therapy in a patient with advanced-stage large cell neuroendocrine carcinoma of the cervix.


He was treated sequentially with prednisone and azathioprine (2 weeks), decreasing doses of prednisone alone (21 months), and no immunosuppressive drugs (10 months).


After admission, she received oral calcium polystyrene sulfonate and sorbitol to treat hyperkalemia.


He has remained asymptomatic.


Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.


This reaction is better known with carbamazepine and phenytoin, but is less common with broad-spectrum antiepileptic drugs such as valproic acid.


The patient did experience nasal mucosal friability and diffuse hyperpigmentation of the face and hands.


The pseudolymphoma syndrome is a reversible reactive condition consisting of fever, lymphadenopathy and generalized rash.


The patient developed severe hepatitis after chemotherapy and, despite achieving complete remission of the malignancy, died of hepatic failure.


To rule out fibrin sheath formation, catheter dye studies need to be obtained when fibrinolytic therapy has failed to restore catheter function.


Acute pancreatitis was confirmed surgically.


Electron microscopic examination of the heart revealed changes characteristic of adriamycin cardiomyopathy.


We report the 1st case of R. equi brain abscess in a patient receiving corticosteroid monotherapy and review the literature for risk factors and sites of infection.


A case of intravenous catheter-related cutaneous aspergillosis and Aspergillus fumigatus fungemia in an HIV-positive patient with Burkitt-cell acute lymphocytic leukemia is reported.


Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.


PFGE revealed different patterns of banding, excluding that interpatient contamination occured.


Other mechanisms have been postulated by other investigators.


A challenge with clozapine was feasible and showed no clinical symptoms of eosinophilia.


The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.


Ketanserin in the treatment of protamine-induced pulmonary hypertension.


The majority of patients, however, do not require the use of steroids.


Sedation in the morning was identified as an important adverse event, which should be addressed by reducing the dose.


Upon admission, all home medications, including pantoprazole, were reinitiated based on the patient's medication list.


This report describes the first case of insulin-induced cardiac failure in a patient without underlying heart disease.


Physicians who now routinely treat RLS patients with dopaminergic agents should be aware of this abuse potential.


In this event the occurrence of neurotoxicity does not correlate with serum lithium levels.


A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.


It should therefore be instituted in good time in potentially life-threatening cases of intoxication.


Early signs of toxicity in the 2 survivors were peripheral neuropathy (day 4), bone marrow toxicity (day 5), gastrointestinal toxicity (days 6 and 7), and hypertension (days 7 and 8).


We report on a patient who underwent renal transplantation using Campath-1H induction and tacrolimus maintenance therapy who developed HUS, which was managed by plasma exchange and switch to Rapamycin.


We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.


A case is presented in which a 68-year-old man became delirious after being withdrawn from a low dosage of alprazolam.


CONCLUSIONS: Topical tacrolimus 0.03% ointment seems to be a promising second-line immunosuppressant in management of high-risk grafts.


All patients presented with sudden, very marked decrease in vision, with little or no pain, tenderness, conjunctival redness, or discharge.


Also, there are some suggestions of an underlying susceptibility and possibly a genetic predisposition, at least in some patients.


The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.


BACKGROUND AND OBJECTIVES: Penile erections following the initiation of either axial regional or general anesthesia is rare; however, when it occurs in patients undergoing urologic procedures it may delay, or even cancel, the planned surgery.


We hypothesized that vigorous rubbing of the eye of the atopic patient might cause limbal erosion that could lead to exposure of the angle-supported AC IOL haptic through the limbus.


Normeperidine is eliminated by the kidneys and accumulates in patients with renal insufficiency, sickle cell disease, and cancer.


A 33-year-old man with a history of recreational benztropine abuse presented to the emergency department with confusion, abdominal pain, and distention.


CLL and AML/MDS were diagnosed concurrently in two patients.


Biopsy of the skin rash demonstrated superficial perivascular lymphocytic infiltrate and was consistent with a drug reaction.


Accidental intra-arterial injection of drugs is a sporadic complication in i.v. drug addicts.


Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.


The changes in trace metals after DFO treatment were not consistent.


Temporary neurologic abnormalities were observed in one out of 23 patients undergoing chemotherapy with high-dose methotrexate (HD-MTX) for osteogenic sarcoma.


Cardiac disease is a significant complication of childhood oncologic therapy.


PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.


We describe a patient who developed granulocytopenia and fever after taking dipyrone and discuss the available literature.


Charcoal hemoperfusion and sequential dialysis were performed because of the serious risk of fatality following such a massive dose of dapsone.


Because the primary reservoir of S. agalactiae in the human body is the gastrointestinal tract, and because no findings suggested an alternate portal of entry in our male donor, a gastrointestinal source was suspected.


Laboratory tests revealed elevated serum creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase.


Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.


Salmonella meningitis and multiple cerebral abscesses in an infant.


We suggest that patients receiving a high dose of vinblastine are at risk for the development of this syndrome.


NMS must be considered as part of the differential diagnosis of fever in burn patients receiving medication known to cause the syndrome.


Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.


After a total of more than 500 cardioversions, all antiarrhythmic medications were withdrawn, and the nonselective beta-blocker propranolol was initiated.


Onychomycosis. New therapies for an old disease.


Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.


Nutritional support via enteral feeding tubes may interfere with the response to medications by a number of mechanisms.


This mode of therapy was effective in treating severe gingival hyperplasia in a patient receiving systemic androgen therapy.


Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.


This observation might suggest caution when cisplatin is used in patients with cardiac disease or pretreated with other potential cardiotoxic antineoplastic agents.


We noted C. striatum to be the infecting pathogen or copathogen in six patients.


Linear IgA bullous dermatosis responsive to a gluten-free diet.


A 33-year-old woman visited our dermatologic clinic complaining of frequent oral ulceration for 10 years and generalized discoloration of her skin for 5 years.


One of three stool samples was positive for the presence of occult blood.


There have been only two reports of cimetidine-induced hepatitis.


We propose a common mechanism: the vasoconstrictors caused systemic hypertension, increased left ventricular afterload, decreased left ventricular compliance, and decreased cardiac output.


We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx.


The site of thrombosis and the chronological relationship with the IIR implicates a hypersensitivity to infliximab in the causation of the venous thrombosis in this case.


The role of GP IIb/IIIa inhibitors in patients with NSTE ACS and elevated troponin levels who are undergoing PCI has been well established, even for patients receiving high-dose clopidogrel.


CASE SUMMARY: A 46-year-old African-American man experienced recurrent grand mal seizures during intravenous infusion of amphotericin B, then petit mal seizures as the infusion was stopped and the drug concentrations decreased with time.


Recurrent hepatitis C and CSD were ultimately managed by the application of pegylated interferon.


Infliximab therapy in pediatric Crohn's pouchitis.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


DIAGNOSIS: Sustained ventricular tachycardia possibly owing to thalidomide treatment.


Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.


No regional side effects were noted.


Patients with RA received intradermal (id) injections of di-Lex incorporated in liposome or of high molecular weight glycoprotein, or tumor associated carbohydrate antigen (TCA), containing the same carbohydrate epitope as di-Lex.


We report on a patient with thrombosis of a prosthetic mitral valve who developed severe embolic complications following the administration of the thrombolytic agent.


This is a case report of subtle, mild hypothermia in a 54-year old female patient receiving risperidone for schizophrenia.


The serum immunoglobulin level returned to the normal range after the prednisolone was tapered off.


We evaluated drug-specific T cell responses in a patient with refractory partial seizures and paroxysmal kinesigenic choreoathetosis successfully treated with clinical desensitization to phenytoin.


We report here the first case using posaconazole for treatment of trichosporonosis in a liver transplant recipient caused by T. mucoides.


L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.


Antibiotic lock technique.


Mr. C. was less tired and had more energy following his first and subsequent courses of therapy.


A recheck of blood chemistries confirmed hyponatremia.


Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.


Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.


The subsequent reabsorption of free water from the fluid collection, with the contribution of postoperative hypotonic intravenous fluid administration and possible transient inappropriate antidiuretic hormone (ADH) secretion resulted in acute dilutional hyponatremia and consequent seizures.


Lidocaine (a sodium channel blocker) serves as an antiepilepsy drug in neonates.


After the initial pairings, the taste alone was offered between CY treatments.


The immunopathogenesis remains obscure, but is suggestive of an antigen-specific process requiring the presence of or exposure to ibuprofen.


A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.


Folinic acid, the 5-formyl derivative of tetrahydrofolic acid, is the active form of folic acid.


Subfascial hematoma remains a rare and self-limited complication of thrombolytic therapy.


Crohn's disease has not been associated with its administration.


Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.


Complete remission was observed after 6 to 10 weeks of imiquimod 5% (10 mg/cm of skin cancer) treatment.


Eleven were seropositive and 2 had Felty's syndrome.


Our experience supports hemodialysis for ESRF patients with atenolol toxicity.


A 70-year-old homebound patient was experiencing new onset porthostatic hypotension and lightheadedness.


Due to the absence of other contributing factors and the temporal relationship between tolterodine and prolonged INR, the event was determined to be a probable drug interaction.


During PUVA treatment a 66-year-old woman with mycosis fungoides in stage III suddenly developed widespread papulonodular lesions of alarming clinical and histological appearance.


Ninety-two microg kg-1 were given thereafter at time intervals of 2 h until 12 h, then every 3 h until 24 h, and every 4 h until 48 h after surgery.


Following this incident, the patient was seen weekly and treated with conjugated vaginal oestrogen cream.


MDS was diagnosed 8.4 months after beginning TMZ.


Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.


Currently, a national randomized trial by the National Prostatic Cancer Project is evaluating this therapeutic innovation.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


Treatment included induction chemotherapy in preparation for a bone marrow transplant, which resulted in the disappearance of the cutaneous lesions.


The eighth exhibited concentric constriction.


No abnormalities were identified on review of collection and processing records.


The drug was administered by continuous subcutaneous or intravenous infusions using a light weight portable constant infusion device.


BACKGROUND: Pelvic actinomycosis is a chronic suppurative inflammatory disease caused by the anaerobic Gram-positive bacilli Actinomyces israelii.


While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.


A cerebrospinal fluid examination meningitis.


CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.


Pulmonary nodules in osteosarcoma patients: differential diagnosis of central venous catheter-related infections in the lungs.


Discontinuation of the drug appeared to be responsible for the resolution of symptoms.


Levamisole was administered for 5 weeks (total dose, 1,500 mg).


We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.


Spinal cord compression induced by steroid therapy: CT findings.


RT-PCR and genomic PCR methodologies were used to identify a G to A mutation in the GT 5' splicing recognition sequence of intron 14, resulting in a 165-bp deletion (corresponding to exon 14) in this patient's DPD mRNA.


On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.


Awareness of this disease and need for prompt institution of therapy is stressed.


No severe side effects occurred, except for slight pain in the nodules after infusion and an urticarial reaction at the tumor sites.


Alopecia, nausea, and vomiting were attributed to the cyclophosphamide component of the therapy.


Liver biopsy disclosed submassive hepatic necrosis.


A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.


Disodium cromoglycate inhibited both responses.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


Iron was absent.


CONCLUSIONS: Our report describes a case of rhabdomyolysis possibly caused by C. mukul and underlines the need for active surveillance of natural products.


Percutaneous transseptal mitral valvuloplasty was attempted in a patient with severe rheumatic mitral stenosis.


Five patients took a combination of herbs and presented with jaundice, fatigue and pruritus.


Combined occlusion of the central retinal artery and central retinal vein is an infrequently encountered clinical entity.


Presumed reactivation of herpes zoster ophthalmicus following laser in situ keratomileusis.


No relationship between amisulpride and rhabdomyolysis was found.


The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.


Vitamin K2 was infused along with discontinuation of warfarin.


This isolate was lost in storage and could not be characterized further.


Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.


Following a closed mitral valvotomy, she received quinidine, 1.2 g/day, without interruption for 17 years.


Drug withdrawal and brief steroid therapy resulted in clinical remission within two months of diagnosis.


Along with normal results of a hepatorenal panel and normal serum vitamin B12 and folate levels, no metabolic or endocrinologic alterations were present to explain the nail pigmentation and dystrophic changes.


Hepatolithiasis (intrahepatic stone) during octreotide therapy for acromegaly: a case report.


A prolonged, complete disappearance of B-cells from the peripheral blood was observed.


Since August, 1989, the primary immunosuppressive agent is FK-506 (Tacrolimus).


Cholesterol embolization (CE) is a potentially serious complication associated with invasive arterial maneuvers, in which standard therapy has not been established.


It has relatively weak effects on norepinephrine and serotonin reuptake but possesses significant dopamine agonist and reuptake blocking effects.


A brief review of organophosphate poisoning and the unique features of our case are presented.


The harlequin color change is an unusual cutaneous phenomenon observed in newborn infants as transient, benign episodes of a sharply demarcated erythema on half of the infant, with simultaneous contralateral blanching.


Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.


We present the first report of N. exalbida brain abscess in a 63-year-old male patient with follicular lymphoma.


Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.


Rapidly developing hyperglycemia during treatment with olanzapine.


Chest radiograph revealed diffuse bilateral infiltrates.


Fibrin sheath formation and chemotherapy extravasation: a case report.


She remained asymptomatic during the therapeutic period and the pulmonary nodules resolved six months later.


On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.


Traditional topical measures to reduce local tissue damage, including corticosteroids, sodium bicarbonate, and ice applications, have not consistently demonstrated beneficial effects.


Malpractice litigation was brought about because the patient alleged that he had steroid cataracts, which resulted from his having received systemic corticosteroids.


Ultrastructurally, the discrete osmiophilic immune complexes were epimembranous.


METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.


The procedure was carried out without fluoroscopic control and was complicated by a puncture of the thecal sack.


Abdominal sonography and brain CT scan were normal.


If renin is low and plasma aldosterone fails to be suppressed by saline infusion, a trial of dexamethasone would seem indicated before other investigations are carried out.


This illustrates a rare case of gastrointestinal adverse reaction to pancreatic enzymes that was treated successfully with desensitization.


Two patients with surgically implanted right atrial silastic catheters for home hyperalimentation developed central vein septic thrombophlebitis.


Only after three subsequent episodes of severe, symptomatic thrombocytopenia over the next four weeks did he say, upon repeat questioning, that he had continued to take quinine for night leg cramps.


Further investigation revealed hyponatremia 112 mEq/L, low serum osmolality, high urine osmolality, normal renal function, normal adrenal and thyroid hormones, and high plasma vasopressin 40 pg/mL.


METHODS: A total of 176 burnt eyes of 98 patients suffering from severe eye burns were retrospectively reviewed.


The cancer developed on a very thin endometrium and transvaginal ultrasonography failed to detect it.


We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.


Various etiologic factors have been implicated in PVOD after BMT.


We present the first case of ovarian endometrioid carcinoma and endometriosis in a postmenopausal patient who was treated with tamoxifen for breast cancer.


We reviewed the literature on the effects of corticosteroids and chemotherapy on aaa formation and discuss possible mechanisms for drug action to promote aneurysm expansion and rupture.


In such patients, desensitization may enable the patient to continue treatment with methotrexate.


In our experience and in other limited published data, adverse effects are rare, but prolongation of the QT interval has occurred and multiform ventricular tachycardia is likely a risk.


Can roxithromycin and betamethasone induce acute pancreatitis? A case report.


We reviewed the literature pertaining the management of pelvic actinomycosis.


Recognition of this rare entity will help clinicians avoid aggressive investigative and treatment modalities that can affect the results of PRK.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


While approximately 70% of patients with schizophrenia and other psychotic disorders show a clear-cut reduction of symptoms in clinical trials, there is considerable variation in individual patient outcome, ranging from complete remission to absolute refractoriness.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


The five human eyes of three patients have shown no evidence of intraocular toxicity with a median follow-up time of 3.6 months (range 2.0-6.4 months).


The patient was treated with a combination of vibramycin and rifampicin for 5 months.


We report the case of a 45-year-old man who had disseminated blastomycosis that involved the lungs, skin, and ocular uvea and who was successfully treated with systemic and local antifungal therapy.


Case study: adverse response to clonidine.


Moreover, the perforation occurred despite using a minimum concentration of the drug, risk factors were absent, and the surgery was performed by an experienced surgeon.


The latter was discontinued slowly over a period of 10 weeks.


A few recent individual case reports have suggested that a myasthenic syndrome may be associated with statin treatment, but this association is not well described.


We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.


2-Chlordeoxyadenosine (2-CdA) is an antineoplastic/immunosuppressive agent used to treat hairy cell leukemia (HCL), chronic lymphocytic leukemia, and low-grade lymphomas.


Examinations 1 1/2 to 7 1/2 years after therapy revealed all of the patients to be within normal range for height and weight, but 3 of the 6 patients treated for 8 months or longer were in the lower range of normal.


We describe seven cases of retinal pigment epithelial (RPE) tear, which developed in seven eyes of seven patients following PDT.


The route of transmission may have been direct contamination of the connection device or bacterial translocation through the gastrointestinal tract.


She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy.


Immunofluorescent study showed granular deposits of IgG and C3 complement along glomerular basement membranes.


The child, a 4-year-old boy, had unilateral retinoblastoma with metastatic spread to the central nervous system.


Since this amount of FAB was insufficient to bind all DGTX present in the serum, cardiac DGTX toxicity (total AV-block) persisted.


The mean time from starting MMF to the development of neutropenia was 4 months.


CONCLUSIONS: Topical tacrolimus at low concentrations (0.1%) shows promise in the management of oral lichen planus-like c-GVHD.


A boy with chronic neutropenia and recurrent inflammatory skin lesions developed multiple erythematous nodules following administration of G-CSF.


CONCLUSION: In this case of O. sulphureo-ochraceum as a human pathogen, the organism caused endophthalmitis after cataract extraction.


ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.


Vaccine-associated herpes zoster ophthalmicus [correction of opthalmicus] and encephalitis in an immunocompetent child.


Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.


None of the patients treated with acyclovir had evidence of active varicella-zoster virus infection at post-mortem examination, but two had disseminated bacterial and fungal infections.


CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.


This report describes the pathological changes in liver biopsy samples taken from 2 children who developed liver failure after combined chemotherapy for Wilms' tumor.


Fusarium infection after solid-organ transplantation.


In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.


The role of IFN-beta in inflammatory musculoskeletal disease is unclear.


Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.


The case of an adult who developed both hepatic dysfunction and an impaired macrophage migration after exposure to cimetidine is discussed.


Angiosarcoma developing after curative induction chemotherapy and radiotherapy for locally advanced squamous cell carcinoma of the larynx.


Topical dimethylsulfoxide may prevent tissue damage from anthracycline extravasation.


From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).


Abdomen CT scan showed diffuse circumferential thickening of ileum wall typical for ileitis, narrowing of the lumen, disturbance of peristaltic.


Awareness of the condition is therefore of continuing importance.


The patient was successfully treated with medical management and insertion of an implantable cardioverter defibrillator.


Careful echocardiographic monitoring is indicated in such cases.


A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.


Role of early diagnosis for a noninvasive treatment of pulmonary thromboembolism in leukemic children.


The occurrence of allergic reactions to steroids is reviewed, and suggestions for management of pulsed IV methylprednisolone therapy are made.


Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).


Outpatient carboplatin desensitization in a pediatric patient with bilateral optic glioma.


The association of ergot toxicity and iliac dissection has not been previously described.


Two patients with classical effort-induced angina pectoris associated with abnormal ST-segment depression on graded exercise testing and normal coronary arteriograms are described.


Norethisterone in these 69 pregnancies accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive births.


3 of the 5 previously untreated patients achieved biochemical and bone-marrow complete remissions.


We describe a 54-year-old, human immunodeficiency virus-positive man with a history of sulfonamide allergy who received treatment with pentamidine for Pneumocystis jiroveci pneumonia.


Ciprofloxacin-induced toxic epidermal necrolysis in a patient with systemic lupus erythematosus.


We report a case of calciphylaxis that may very well be due to a long-term steroid use in a rheumatoid arthritis patient who had neither end-stage renal disease nor hyperparathyroidism.


Captopril, a competitive inhibitor of angiotensin-converting enzyme, is widely used in the treatment of hypertension and heart failure.


Can ketamine prescribed for pain cause damage to the urinary tract?


This phenomenon has been described with gentamicin though never with amikacin.


CONCLUSION: Based on the easily managed toxicities and apparent efficacy of the regimen of weekly nab-paclitaxel and daily sunitinib, we conclude that further evaluation is warranted to assess the efficacy of this combination therapy in previously chemotherapy-treated patients with advanced thoracic cancer.


In addition, while cases of loop diuretic-induced pancreatitis, including furosemide, have been published, the allergic manifestations with both sulfonamide antibiotics and non-antibiotics in our patient suggest possible cross-reactivity between these 2 drug classes.


A 33 year old male Nigerian presented with widespread involvement of peripheral nerves, several of which were tender and painful.


Five such patients were identified and their clinical course was reviewed.


The patient's Ewing sarcoma remained refractory to treatment despite continuous intensified chemotherapy and was complicated by a therapy-related acute myeloid leukemia with 11q23 abnormality.


The presented case illustrates that a combined overdose of tricyclic antidepressants and neuroleptics enhances the possible toxic effects of each drug and especially the risk for adverse cardiac events.


Visual changes secondary to initiation of amiodarone: a case report and review involving ocular management in cardiac polypharmacy.


We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.


Ofloxacin: a probable cause of toxic epidermal necrolysis.


Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.


Clevudine (L-FMAU) is a thymidine l-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection.


Distraction and relaxation training in the treatment of anticipatory vomiting: a single subject intervention.


OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.


Intravenous TMP/SMX failed to improve the lesion.


Well-differentiated endometrial adenocarcinoma of the secretory type (FIGO Grade 1) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma.


Aluminum overload can have a detrimental effect on erythropoiesis which, in turn, can blunt the effectiveness of Epoetin alfa.


Biopsy of the skin lesions revealed leukaemia cutis, which led to the discovery of acute myelogenous leukaemia.


Most patients with FH deficiency associated HUS progress to end-stage renal disease despite plasma therapy.


The injection of bulking agents into the urethral submucosa is designed to create artificial urethral cushions that can improve urethral coaptation and hence restore continence.


We describe a 53-year-old man with Churg-Strauss syndrome and subsequent opportunistic cytomegalovirus enterocolitis.


CONCLUSION: The recognition of this atypical presentation with a combination of opthalmoscopic, angiographic and OCT findings may avoid inappropriate diagnosis and treatment with corticosteroids.


The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.


Prolonged requirement for ventilatory support in a patient with Eskalith overdose.


However, such bacteria may also be involved in various postoperative orthopedic infections, including prosthetic joint infection.


Valproic acid is commonly and effectively used in the treatment of idiopathic generalized epilepsies, including juvenile absence epilepsy.


It is suggested that the plasma electrolytes of patients at risk should be monitored.


The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.


Three cases are described in which periorbital topical corticosteroids appear to have resulted in raised intraocular pressure or glaucoma.


Massive plasmocytosis due to methimazole-induced bone marrow toxicity.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.


The patient was successfully treated with ciprofloxacin.


Sideroblastic anemia due to linezolid in a patient with a left ventricular assist device.


CONCLUSION: In our patient, substantially increased glucocorticoid levels were associated with severe insulin resistance, retarded wound healing, and persistent infections.


We present the case of a 41-year-old male undergoing surgery for restenosis at the site of a repair.


He was treated with intravenous quinidine gluconate and oral doxycycline, in addition to blood transfusion, and he responded well to the treatment.


Initially, the patient was treated with topical and systemic antibiotics, and corneal epithelium quickly regenerated.


Septic knee arthritis after intra-articular hyaluronate injection.


Visual acuity had improved to 20/30(+2) O.D. and 20/30 O.S.


This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.


A good example is the concern about using oral cobalamin when treating pernicious anemia.


We feel that hormonal treatment may be tried as first modality in the treatment of Youssef's syndrome, before resorting to surgery.


Metamizole, a nonsteroidal antiinflammatory agent, is prohibited in the United States because of the risk of agranulocytosis but is widely used in Mexico and other countries.


Nesiritide (recombinant B-type natriuretic peptide) is often given for symptomatic relief of acute decompensated heart failure in adults.


Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.


One patient on ouabain also developed cardiomyopathy.


Infliximab, an anti-TNFalpha antibody, was given with the aim of treating an enterocutaneous fistula, but it also produced a marked biochemical and histological improvement in the TPN-related cholestasis.


Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.


Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.


This case also constitutes an experimental model.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


Because relapse of histoplasmosis may occur as long as nine years after treatment, immunocompromised patients being treated with ketoconazole must have close long-term clinical follow-up.


RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.


We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).


Etoposide, an epipodophyllotoxin, is a topoisomerase II inhibitor that interacts with DNA to potentiate leukaemogenesis.


Acute amphotericin B overdose.


Amifostine, also known as WR-2721 (S-2-(3-aminopropylamino)-ethylphosphorothioic acid), is an organic thiophosphate cytoprotective agent used to reduce the frequency of severe xerostomia in patients with cancer undergoing postoperative radiation of the head and neck.


A new case of Creutzfeldt-Jakob disease associated with human growth hormone therapy in New Zealand.


Recommendations are made with regard to screening such patients for glaucoma.


Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.


Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.


Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.


Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.


Risk factors present for acquired long QT syndrome were mineral dysbalance and a history of alcohol abuse with hepatic impairment.


This report addresses the association of multiple sclerosis and intracranial meningioma and discusses the effect of interferon treatment on tumour progression.


The endophthalmitis recurred after the medical treatment was discontinued.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.


Pulmonary infiltrates resolved within 2 months of treatment.


Four of five patients with ALL achieved a complete remission (CR) (including the bcr/abl case) while among patients with AML only the one with APML achieved CR.


Colchicine has been reported to be a safe and effective medication in the treatment of early phase of Peyronie's disease (PD).


The baby was born healthy, without any anomalies.


In conclusion, the diagnosis of leflunomide-pulmonary-renal syndrome was rendered.


This rash rapidly progressed to painful hardening of the area.


Gelofusine allergy--the need for identification jewellery.


Although calcium deficiency has not been incriminated as a cause of rickets in the past, it is possible that in very tiny premature infants rapid growth requirements lead to a relative calcium deficiency which may be manifested as uncalcified osteoid.


A whitish plaque in the lips and bilateral buccal mucosa, burning, taste disturbance, and xerostomia were observed.


Various case reports concerning dapsone-induced agranulocytosis are reviewed.


Electromyography, muscle biopsy, and the course of the patient's illness were consistent with polymyositis.


Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.


Other potential causes of renal failure were not present in our patient and his renal function gradually recovered with the cessation of suramin treatment.


The pathogenesis of the hypoglycemia was investigated by assessment of serum insulin, plasma glucagon and serum alanine levels during disopyramide rechallenge.


We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.


Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes.


This evidence admonishes against the prolonged use of these drugs in non-fatal disorders.


CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.


RESULTS AND CONCLUSIONS: Clonazepam provided effective relief for > 6 months in two patients with shooting/shocking phantom limb pain.


The patient had been receiving acenocoumarol 4 mg/d for 10 years for episodes of atrial fibrillation and recurrent deep venous thrombosis.


We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI).


A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.


There was no sign of bacterial, viral, or fungal infection in either case.


Limited data are available regarding this treatment in the pediatric population.


CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.


However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients.


However, the pathogenetic mechanism has never been well investigated.


Multiagent chemotherapy alone was successful in achieving a durable remission and euthyroid state.


Gastrointestinal toxicity associated with the use of this drug is common but generally mild to moderate.


The possibility of deep vein thrombosis caused by the compression of the veins by necrotic tumor should be considered in patients with abdominal or pelvic metastases of GIST, including patients treated with imatinib.


OBJECTIVES: The purpose of this study was to characterize the clinical features, treatment, and outcomes of patients with fungal ICD infections.


METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.


The lymphoma was of the CD4+ cytotoxic T-cell lineage, and the tumor cells also expressed CD56.


STUDY DESIGN: Case report and clinical discussion.


RESULTS: Chemotherapy-induced HUS was aggressively treated with plasmapheresis, high-dose steroids, vincristine and rituximab.


She had been receiving TPN for 2.5 years when she developed cholestasis which worsened despite adjustments to her TPN regimen.


Phenytoin desensitization in a child with symptomatic localization-related epilepsy.


We present a case of successful stenting of the left main coronary artery (LMCA) in a patient with ACAD.


Cross-reactivity between clindamycin and ampicillin is also demonstrated in one patient.


Biventricular thrombi in dilated cardiomyopathy: massive simultaneous pulmonary and systemic embolisation.


Cardiac arrest occurred in all patients, and four patients died.


Leflunomide-induced toxic epidermal necrolysis in a patient with rheumatoid arthritis.


We present two sets of monozygotic twins with twin-to-twin transfusion, where in utero ductal closure occurred in the donor twin while the recipient twin appeared unaffected.


Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.


Intravenous warfarin provides an alternative administration route for patients who cannot receive the oral formulation and cannot be administered subcutaneous low-molecular-weight heparins due to adverse effects.


The recognition, differential diagnosis, and management of this syndrome in children are discussed.


However, possibly due to the bone marrow toxicity of the tuberculostatic drugs, the patient tolerated only low doses of cytostatic therapy.


INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).


CONCLUSION: The two reported cases of tocolysis-induced vulvar edema were not fatal and resolved after repositioning the patient in one case and by cesarean section in the other.


Inadvertent and accidental epinephrine overdose might result in potentially lethal complications.


Treatment of proteinuria with low-molecular-weight heparin after renal transplantation.


Metformin-associated lactic acidosis (MALA) is a serious metabolic complication that occurs because of metformin accumulation in patients who become dehydrated or developed acute renal failure.


These myths underscore the importance and utility of outcome-based research to help guide physicians in their practices.


A comparison of the pharmacological actions of successful and unsuccessful treatments for AHC is made.


Associated clinical and electrophysiological polyradiculopathy and multiple mononeuropathy of the lower extremities were observed.


Marked sinus tachycardia resulting from the synergistic effects of marijuana and nortriptyline.


Cefoxitin therapy for Mycobacterium fortuitum bacteremia with associated granulomatous hepatitis.


We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.


The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.


BACKGROUND: NVP is a non-nucleoside reverse transcriptase inhibitor used in the treatment of Human Immunodeficiency Virus (HIV) infection.


Naloxone, a pure opioid antagonist, has demonstrated reversal effects from clonidine intoxication.


None of the seven patients receiving MPP on PUVA had a reaction.


Withdrawal syndromes, delirium tremens in particular, are known to cause delirium.


CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon.


Throughout the patient's clinical course, the activity of plasma VWF-cleaving protease, which specifically cleaves the Tyr842-Met843 bond of the subunit and reduces its multimeric sizes, was quite normal (95-119%).


Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.


CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.


The steps that can be taken to promptly reach a diagnosis and to successfully treat this life-threatening condition are described.


It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.


Additive pulmonary toxicity with melphalan and busulfan therapy.


A 51-year-old woman who had repeated episodes of dizziness, nausea, and vomiting was diagnosed with vertebrobasilar insufficiency.


It is sometimes the sorrow of failed action and sometimes the sorrow of failed conduct.


Terbutaline for chronotropic support in heart transplantation.


She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.


We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).


INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B.


Cutaneous plasmacytoma is an uncommon observation in clinical practice.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


Doses of 0.8-1.0 mg/kg of L-AmpB were administered intravenously every 24-72 hr.


He ran out of medication, was unable to refill his prescription for 2 days and presented to the emergency department in status epilepticus.


DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.


On the basis of survival data, it is not clear that use of MTX adversely affected the natural course of their HIV disease.


The treatment of paracetamol overdose with charcoal haemoperfusion and cysteamine.


The hypothyroid status was corrected by increasing the dose of levothyroxine.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


The clinical presentation and management of a newborn whose mother received lithium during pregnancy is presented.


The gross appearance of the tumor during surgery was typical of neurilemmoma.


We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.


CONCLUSION: This report shows thatimmune-mediateddiabetes mellitus can occur as a late complication of alfa-interferon therapy.


CONCLUSIONS: Confocal microscopy can be a useful, noninvasive imaging technique helpful in the study, diagnosis, and treatment of Acanthamoeba keratitis.


The patient died of respiratory failure after 8 days of steroid infusion and erlotinib discontinuation.


A skin biopsy specimen disclosed intracorneal pustule composed of neutrophils and lymphohistiocytic infiltrate in the dermis.


Prolongation of the QT interval associated with ventricular arrhythmias has been the most common cause of the restriction or withdrawal of drugs from the market in the past 10 years.


To date, only three cases of seizures associated with amphotericin B have been reported in the literature, but healthcare providers should be aware of the potential for this rare adverse effect.


In two patients opportunistic infections did not develop.


A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented.


Transient paralysis associated with epidural steroid injection.


Thereafter, Mycobacterium tuberculosis was detected in blood cultures and specimens of bronchoalveolar lavage, thus indicating disseminated TB.


Multifocal ERG showed abnormalities that sometimes correlated with the visual field appearance and confirmed that the deficit occurs at the retinal level.


Although the treatment of S. aureus endocarditis in immunosuppressed transplant patients has traditionally resulted in loss of their allograft, prompt diagnosis and appropriate antibiotics with continued immunosuppressive therapy resulted in a successful outcome and allograft preservation in this case.


Microscopic examination of random colonic biopsies by two consecutive sigmoidoscopies revealed angulated crystals with a characteristic crystalline mosaic pattern on the ulcerated mucosa, which were consistent with Kayexalate crystals.


We describe the clinical and biological characteristics and outcome of five patients with post-HSCT MN, review the previously reported cases and discuss the pathogenic aspects of this nephropathy.


Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).


Myoclonus and EEG bursts were both spontaneous and stimulus induced.


Following prompt recognition and diagnosis, intravenous thrombolytic therapy was administered 2 hours after symptom onset.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


The condition is primarily reported in patients with end-stage renal disease, and is associated with significant morbidity and mortality.


Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream.


All patients had temporary relief of signs or symptoms of inflammation.


Six weeks later a more severe syndrome of dysarthria and ataxia developed during a second cycle of treatment.


We report the case of a patient who experienced severe depressive symptoms after both the first and second course of treatment with a corticosteroid during chemotherapy and ultimately committed suicide.


We share our experience in the treatment of candida peritonitis using oral fluconazole.


CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.


She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.


In 6 of 10 patients, several treatment attempts either had failed or could not be used due to severe side effects or underlying disease.


These cases indicate the potential for development of acral cyanosis, livedo reticularis, or Raynaud symptoms with these medications and their potential contribution to a vasculopathy.


Minocycline as a cause of drug-induced autoimmune hepatitis.


Resolution of a giant atrial thrombus following anticoagulation therapy.


A treatment attempt with allopurinol was initiated while antiviral therapy was continued and was successfully completed after 6 months.


The effusion resolved after the withdrawal of the drug and the beginning of anti-inflammatory therapy; there was no relapse during a 10-month follow-up.


After induced delivery at term because of hypertension, repeated laboratory findings showed increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and negative hepatitis C and B markers.


We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.


Risks from use of a prescription drug for other than the intended patient are also highlighted by this episode of poisoning.


After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.


Sturge Weber syndrome with intraoral manifestations.


The patient underwent acute oliguric renal failure, which required treatment with hyperhydration, urine alkalinization, urate oxidase and hemodialysis, with a fatal evolution.In conclusion, the present case report has several peculiarities: that of being one of the rare examples of spontaneous TLS, that of showing an exceptionally severe hyperuricemia, probably the highest ever reported in the literature, and that of the possible increased risk of tumours in patients with Crohn s disease taking inmunosuppressives and/or TNF antagonists.


Medical misadventure = human tragedy.


A month later, he developed clinical and biochemical evidence of modest hepatocellular injury, and therapy was stopped.


Chronic hypotension, infrequent though possible in chronic renal failure patients on hemodialysis, has harmful consequences on their physical state and hence general well-being.


Methyldopa-induced liver injury.


Therapeutic re-exposure with intravenous ceftriaxone 1 g confirmed the diagnosis.


Atropine 1 mg given intravenously resulted in shortening of all P-P intervals without changing the rhythm.


Careful follow-up of so-called "self-limited" insulin edema is encouraged, and the early institution of diuretic therapy is advocated in elderly patients to prevent the development of overt cardiac failure.


Extra caution should be taken in using octreotide or its long-acting analog in patients otherwise predisposed to intrahepatic bile stasis.


Thirty-nine cases are reviewed in which the patients developed a hemolytic-uremic-like syndrome, apparently in response to chemotherapy.


Corynebacterium Group JK pathogen in cerebrospinal fluid shunt infection.


With a median follow-up of 13 months (12 to 17 months), all five patients are well and have shown stable or improved performance status and clinical remission of organ-related dysfunction, including a 50% reduction in daily proteinuria with no change in creatinine, reversal of symptoms of cardiomyopathy and reductions of posterior wall and septal thickening, reversal of polyneuropathy and gastric atony, and resolution of hepatomegaly by computed tomographic scan.


CASE SUMMARY: A 41-year-old woman with a history of proliferative glomerulonephritis from systemic lupus erythematosus was admitted with a diagnosis of cryptococcal meningitis.


We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.


We suggest that nicotinic acid was the cause of his liver disease, that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure, and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity.


The patient received the three agents as short infusions over four consecutive days.


METHODS: We used immunological methods to study a case in which pemphigus herpetiformis occurred in a woman with a history of psoriasis, shortly after a course of ultraviolet B (UVB) therapy.


Orthodontic treatment of patients using bisphosphonates: a report of 2 cases.


Gelatinous transformation of the marrow (GTBM) has been associated with various conditions.


Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.


Three of the dogs died.


Our patient's symptoms were resolved when tacrolimus was substituted for cyclosporine and amlodipine was initiated.


Experience with continuous haloperidol infusions is growing, and it appears to be an effective method for control of severe agitation or delirium.


Anisocoria from transdermal scopolamine.


The follow-up images showed complete occlusion of the pseudoaneurysm after the thrombin injection.


These observations are consistent with the hypothesis that angiotensin-converting enzyme inhibition may cause anemia by increasing renal blood flow and consequently decreasing erythropoietin levels.


Portal hypertension in a patient with chronic myeloid leukaemia.


The typical manifestation is an urticarial or erythematous rash, and pruritus on the face and flexural aspects of limbs, followed by progression to dermatitis.


Polycystic ovarian disease, a condition characterized by unopposed estrinism due to the peripheral conversion of excessive androstenedione to estrone, was found in a 27-year-old infertile woman with an endometrial malignant mullerian mixed tumor.


We have described a man with classic rheumatoid arthritis who had membranous nephropathy associated with nephrotic syndrome not related to gold or penicillamine therapy.


Radiation-induced fibrosis (RIF) is a terminal sequela to irradiation that does not regress spontaneously.


The risk of cardiac decompensation in infants with supraventricular tachycardia and congestive cardiac failure should be kept in mind prior to administration of verapamil.


However, many of the patients had been treated surgically for recurrences once or several times previously.


The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.


Both patients were normal in the initial study, but later developed pathological diploid cell lines with structural chromosome abnormalities.


A standard verteporfin dose was given and a photodynamic treatment (PDT) protocol was followed.


The patient underwent radical cystectomy and an ileal conduit was created.


CONCLUSION: These results suggest that rifampin-impregnated silicone catheters could become a valuable tool in the treatment and prevention of shunt infections.


A brief discussion of this case and the use of digoxin-specific antibodies is presented.


Here we report an unusual case of mixed Wilms' tumour and angiosarcoma in a 38-year-old female patient who presented with haematuria and right lower back pain.


He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.


The alpha(1)-adrenoceptor occupancy by endogenous norepinephrine was increased in a dose-dependent manner by milnacipran, whereas fluvoxamine had essentially no effect.


Incorrect identification of the organism as Corynebacterium J-K led to a change of antimicrobial therapy and clinical deterioration.


Unexpectedly, the patient developed a severe skin reaction in the region exposed to the radiation field, and a bilateral subdural hemorrhage, following radiation therapy.


Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity.


Electron microscopy showed morphological abnormalities in the matrix.


That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).


An anaplastic large cell lymphoma that was negative for Epstein-Barr virus and positive for Ki-1 (CD30) presented as a polypoid scalp mass in a 56-year-old man 16 years after renal transplantation.


Many symptoms of hyperthyroidism are identical to the adverse effects of the commonly used inhaled bronchodilators and include tremor, nervousness, tachycardia, wide pulse pressure, palpitations, emotional lability, agitation, nightmares, aggressive behavior, and diarrhea.


Dysgammaglobulinemia in steroid-dependent optic neuritis: response to gammaglobulin treatment.


Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.


After desensitization, phenytoin-specific CFSElow CD4+ cells decreased to background level.


Impetigo herpetiformis is a rare non-infectious pustular dermatosis of pregnancy.


Rupture of the plantar fascia.


Recently there have been concerns relating to liver and now kidney toxicity.


Isoniazid and ethambutol as a cause of optic neuropathy.


The risk of developing BMTN may be greater with the use of more intensive chemotherapy and higher total body and tumor bed irradiation.


CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.


Emergency selective coronary angiography was performed.


Bicarbonate hemodialysis treatment should take place early in the course of management, especially in patients with severe metabolic acidosis who fail to respond to intravenous bicarbonate therapy or in whom renal failure is present.


We report two cases of F. oryzihabitans bacteraemia associated with the use of Hickman catheters for administration of the patients' chemotherapeutic agents.


CONCLUSION: Serial amniocentesis may place patients at elevated risk for Candida chorioamnionitis and subsequent preterm delivery.


In fact, to our knowledge only 37 cases, including this one, have been documented.


Before treatment thyroid function tests were normal and anti-thyroid (anti-thyroglobulin and anti-thyroid peroxidase) Abs were negative.


Thus, the transient increase in blood glucose was not related to a pre-diabetic status.


It is currently undergoing evaluation as an adjunct to bone marrow transplantation but its use in patients with metabolic disorders, such as Hurler's syndrome (HS), has not been explored.


Mitoxantrone and cyclophosphamide in advanced breast cancer: a pilot study.


This phenomenon is the main feature of the dopamine dysregulation syndrome.


A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.


A case of steroid induced exophthalmos in a patient with systemic lupus erythematosus with renal involvement is described.


Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma.


RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.


DISCUSSION: In general however, it must be remembered that problems with oral hypoglycaemics are rare.


The most common complication associated with this procedure is an alteration in sensation over the donor site manifested as chronic pain, hyperesthesia, dysesthesia, or diminished sensitivity resulting from superior cluneal nerve (SCN) injury.


In addition, patients with clinical signs suggestive of NMS should be monitored more carefully.


INVESTIGATIONS: Physical examination, cerebral MRI, brain biopsy, skin biopsy, immunohistochemistry, bronchoscopy with bronchoalveolar lavage, and laboratory tests.


PURPOSE: To describe bilateral corneal endothelial dysfunction in a patient with Parkinson disease who was treated with long-term amantadine.


Levosimendan infusion was started at the sixth hour of cardiopulmonary bypass circulation.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


All patients were under immunosuppressive therapy.


A patient with a right atrial thrombus and recurrent pulmonary emboli secondary to permanent pacemaker insertion is described.


A marked decrease of the free form of protein S was documented.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency.


In four of five eyes the LASIK flap was amputated.


Corticosteroid therapy was continued for 8 months since there was still improvement of pulmonary function studies.


We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.


An initial dose of intraventricular vancomycin should take into account volume of distribution (ventricular size) to obtain a peak cerebrospinal fluid concentration of 20 to 30 micrograms/mL.


Older therapies that have been widely accepted for a long time might not have had controlled trial data behind recommendations for their use, and once practice patterns become widespread, it is hard to change.


Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.


The pathophysiology of the syndrome is unknown.


Although this therapy has a very low toxicity profile, an increase in secondary cancers has been reported.


Since recent studies have reported no negative interactions with concurrent use, we here report three cases (one case of a prolonged seizure, a serotonin syndrome and a focal seizure) of severe lithium-induced side effects while patients underwent ECT without complications and lithium serum levels were still subtherapeutic.


Despite the administration of high doses of rhEPO, toxicity attributable to rhEPO was not observed in either the double-blind or open-label study.


Number twenty-one.


Due to paranoia and agitation, the dose was increased to 5 mg twice daily after 2 days.


OBJECTIVE: Our purpose was to test the efficacy of stanozolol, a drug capable of fibrinolytic enhancement, in treating cutaneous ulcers caused by cryofibrinogenemia.


Epstein-Barr virus-associated lymphoproliferative disease (EBV-LPD) is a serious disorder seen in various states of immunodeficiency, often with a fatal outcome.


He reported adherence to drug therapy and diet.


Cerebral infarcts in a pediatric patient secondary to phenylpropanolamine, a recalled medication.


A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.


We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.


The patient received bleomycin 189 U over five days for preoperative control of a squamous cell carcinoma of the right tongue and tonsil.


Three distinct types of minocycline-induced cutaneous pigmentation have been described.


However, acute cardiomyopathy and pericarditis secondary to methylphenidate use has been rarely reported.


Serum tryptase levels after intramuscular challenge did not increase significantly with regard to the basal levels.


Concomitant aspiration of gastric acid was thought to be the explanation for the severity of these cases.


Niemann-Pick type C is an autosomal-recessive, neurovisceral storage disorder that results from defective cholesterol esterification.


Medication can induce severe ulcerations.


RESULTS: The patient was treated with immediate corticosteroids at the time of initial diagnosis, and emergent re-exploration and debulking of the paraspinal muscles.


METHODS: A 36-year-old man sustained a flap dehiscence following traumatic right eye gouging by a seagull claw.


Also, transcranial Doppler revealed approximate doubling of blood flow velocity in vertebral artery area compared with her baseline value.


A 63-year-old man with rheumatoid arthritis presented with pain and swelling of his right buttock.


Although she had been in complete remission (CR), the structure of the left lung was severely degraded.


SCs increase during chemotherapy, were often unpredictable and led to emotional consequences.


Dose-dependent olanzapine-associated leukopenia: three case reports.


He recommends evaluation for a pulmonary or ophthalmologic injury.


Chymopapain should have been released by the FDA on a Phase IV basis.


This report describes the initial protocol, the gingivectomy, and a 2-year follow-up.


Pulmonary edema as a delayed complication of ritodrine therapy.


In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.


Acute lymphoblastic leukemia as a second malignant neoplasm in a child with medulloblastoma.


Pure red cell aplasia associated with fenoprofen.


OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.


Actinomycosis of the female genital tract has greatly increased over the last two decades.


Overall, SMS 201-995 appears to be a valuable new agent for the treatment of acromegaly, but long-term safety needs to be established.


We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.


The treatment was discontinued and after 2 months the liver parameters became normal.


We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.


A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis.


We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.


Effectiveness of pentostatin (2'-deoxycoformycin) in refractory lymphoid neoplasms.


Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.


Most patients are treated conservatively because an improvement occurs when the absolute neutrophil count rises.


Opioid-related narcosis in a woman with myopathy receiving magnesium.


This is an interesting case because the proarrhthmia of the drug was not tachyarrhythmia, such as ventricular tachycardia or torsades de pointes, but sinus pause.


A careful history and examination, with appropriate investigations, can lead to an accurate diagnosis in such difficult cases.


Although the exact pathophysiological processes involved have not yet been established, the neurotransmitters dopamine, serotonin and gamma amino butyric aid (GABA) have been documented to play a significant role in the generation of hiccups.


Mean time between initiation of gemcitabine therapy and onset of HUS was 7.4 +/- 3.5 months, or 21.9 +/- 10.9 doses of gemcitabine.


Awareness of this unusual side-effect may prevent needless investigation and therapy.


Paradoxical exacerbation of the signs and symptoms of tuberculosis may occur not only after antituberculosis therapy, but also soon after the initiation of a potent combination of antiretroviral drugs in human immunodeficiency virus (HIV) serpositive patients with tuberculosis.


The patients were transferred to intensive care unit, and the treatment was continued after administration of corticosteroids under careful monitoring of vital signs without any further serious reactions.


A case of Hodgkin's disease confined to the CNS, with cerebrospinal fluid negative for cytology, is described in an immunocompetent patient previously treated for hyperthyroidism with 131I.


Traditional neuroleptics have been the mainstay of treatment for agitated behavior in persons with dementia, but these agents have limited efficacy and are associated with high rates of adverse effects, including worsening of already poor cognitive functioning.


Desmopressin--a nontransfusional form of prevention of postextractive bleeding in some patients with von Willebrand's type I disease.


Unusual cause of methadone poisoning.


Pentostatin (2'-deoxycoformycin, DCF) was administered to 17 patients with a variety of lymphoid neoplasms, both T- and B-cell, that were refractory to conventional treatments.


The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.


Nail-changes induced by penicillamine.


Imaging and tissue biopsy revealed a diffuse large B-cell, non-Hodgkin's lymphoma.


During trimethadione treatment, impaired exocrine pancreatic function returned to normal in four of nine patients examined, and diabetes mellitus was well controlled by either diet therapy alone or oral hypoglycaemic agents in eight of 10 patients who did not need insulin before trimethadione treatment.


It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.


Thus, varenicline may not aid smoking cessation in patients undergoing treatment with amphetamine and amphetamine-like drugs.


CONCLUSION: The pigmented cellular membranes observed on these silicone lenses were visually significant to each patient.


Two episodes were incident cases (no prior IBD); one episode was recurrent colitis or a nonincident case (flare of prior IBD).


Mitoxantrone appeared to have no cardiac toxicity.


Experience with five patients in whom impaired renal function developed early during amphotericin B therapy is reported.


Three of 38 children given high-dose cytosine arabinoside therapy developed a previously undescribed complication.


Ophthalmological examination included testing of visual acuity, slit-lamp inspection, fundus inspection, fundus photography and kinetic perimetry.


We describe a patient who developed 3 successive forms of joint manifestations: early HIV related arthralgias followed by drug related arthritis, and more recently by typical RA.


Sequential CT studies of 24 children with infantile spasms on ACTH therapy.


Angiotensin-converting enzyme (ACE) inhibitors are widely used for controlling hypertension.


The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.


Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.


Intraocular ointment after small-incision cataract surgery causing chronic uveitis and secondary glaucoma.


OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.


Only minor endocrine-metabolic changes were seen in this patient.


Diffuse cutaneous candidiasis in a dog.


We conclude that using hemoperfusion is an effective modality which may be used as an adjunct to supportive therapy when there is a need to increase the body clearance of chloramphenicol.


Captopril-induced lichen planus pemphigoides with pemphigus-like features.


DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.


Successful treatment of molluscum contagiosum in the immunosuppressed adult with topical injection of streptococcal preparation OK-432.


Carboplatin hypersensitivity presenting as coronary vasospasm - a case report.


Although the literature on the use of risperidone in elderly patients with dementia consists largely of uncontrolled trials, case reports, and chart reviews, it appears that this agent is effective for managing agitation in this population and does so with a low frequency of extrapyramidal symptoms (EPS).


The most common clinical presentation is fever secondary to a central line infection.


Secondary spontaneous pneumothorax (SSP) is a rare complication of chemotherapy for pulmonary metastases and to the best of our knowledge, only 28 cases have been described, most of which occurred in patients with osteosarcoma or germ cell tumors.


It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.


This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.


This case provides an opportunity to discuss the difficulty of managing two potentially mortal conditions in which the treatment of pemphigus vulgaris may exacerbate the disseminated cryptococcal infection.


In view of the temporary symptomatic action and the seriousness of certain side-effects of desmopressin we recommend that desmopressin be used with caution in childhood enuresis.


A delay in standard emergency room management led to a delay in diagnosis and treatment.


Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.


Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.


The patient had ischemic brain lesions due to cardiopulmonary arrest at 39 weeks of corrected age.


Patients were started on topical tacrolimus ointment 0.03%, twice daily, which was tapered to the lowest possible therapeutic dose that maintained its antirejection efficacy.


Tamoxifen, the first clinically available SERM, was developed in 1966 and approved by the FDA (United States Food and Drug Administration) in 1978.


Pulmonary gold toxicity.


The child had a fair outcome despite of the very acute course of the disease and the presence of a cervical sensory level which usually harbor a poor prognosis.


Ticlopidine withdrawal and treatment with antibiotics, transfusions, and G-CSF helped him to recover.


During 11 months of follow-up, arrhythmia did not recur.


Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.


The current report demonstrates successful treatment, even in the setting of subsequent bone marrow transplantation and immunosuppression, using a combination of surgical resection and posaconazole therapy.


He also presented with skin and lip lesions considered to be chronic graft-versus host disease.


Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.


Interference with smoking-cessation effects of varenicline after administration of immediate-release amphetamine-dextroamphetamine.


Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.


To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.


In all the patients, pellagra symptoms appeared during isoniazid therapy.


Lamotrigine clearance increases throughout pregnancy, and maternal dose increases are often necessary to maintain therapeutic effect.


The present report describes four cases of this association in which tamoxifen had been administered to all of the patients.


We report three young Chinese male patients who underwent aortic valve replacement for severe aortic regurgitation of subacute onset, complicated by recurrent dehiscence of the aortic valve prosthesis, due to aortitis.


In one of these cases, the patient, a 47-year-old man, died 10 days later.


The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced "jitteriness" may be identical.


Chemonucleolysis is a procedure for treatment of low back pain due to discogenic disease in which the drug chymopapain is injected into lumbar disks to produce chemical dissolution of the nucleus pulposus.


Embolic phenomena occurred in 10 (42%) of 24 cases.


The second bowl of decoction probably became more concentrated because of evaporation of water during continued boiling and contained a larger amount of 'maqianzi'.


Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.


Other primary causes of hepatotoxicity (alcohol consumption and viral hepatitis) were also verified in two cases, and in those patients biopsy findings revealed the presence of cirrhotic lesions in liver parenchyma.


Autoantibody assessment showed negative ANA, anti-dsDNA, anti-ENA, and ANCA, but positive granulocyte-bound antibodies (GBA) and neutrophil-specific (CD 16+)-bound antibodies (anti-NA).


Clinical, histological and serological studies--a further 10-year follow-up.


One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.


To determine the effects of reversible medical castration on prostatic size in patients with benign prostatic hypertrophy (BPH), 3 patients with BPH were treated with a GnRH analogue, leuprolide, for six months at a dosage of .2ml (1 mg) s.c. daily.


There are many pertinent issues surrounding the treatment of bipolar disorder during pregnancy.


In addition to illustrating the potential diagnostic confusion with infection or lupus flare, this case is of interest in that the reaction developed suddenly despite the patient's uneventful use of the drug for over two years.


Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.


CONCLUSION: Although the mechanism is not clear, these cases add to several other reports concerning the sudden emergence of obsessive-compulsive symptoms and anxiety symptoms in children treated with atypical antipsychotics.


The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed.


Two probands had borderline mutations; the rest were normal.


Clinicians must be aware of the delicate balance between the signs and symptoms of disease states and the effects of drugs.


Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.


The Hybrizep method (which is available on the Japanese National Health system only for the diagnosis of septicemia) was a useful diagnostic approach for a patient on peritoneal dialysis who had peritonitis.


The literature describing the safety or efficacy of nesiritide in children is minimal, and we know of no data that describe the effects of a nesiritide overdose in adults or children.


BACKGROUND: The synthetic corticosteroid methylprednisolone is used for the treatment of acute exacerbations of Crohn's disease, also in pregnancy.


CLB and N-CLB plasma level dosages and molecular analysis may be useful when a poor metabolic condition is suspected.


He developed VZV reinfection without skin lesions after family exposure and influenza A was community-acquired.


Two elderly women suffered an acute deterioration of renal function after treatment with cefoxitin sodium.


This is the first report of UFT-induced scleroderma-like reaction.


For such tumors to be successfully removed, at least part of the parotid duct must be excised as well.


Staphylococcus aureus is one of the main causes of bacteriaemia.


If suspected, prompt medical assessment should be arranged, including serum glucose and cortisol measurement.


The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).


METHODS: We describe the case of a 41-year-old male with HIV who received protease inhibitor medication and had neurologic deficits rapidly develop.


Diabetes mellitus type 1 in five military aviators: flying with insulin.


Eleven days after initiation of therapy with amiodarone, the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia.


A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion.


Further analysis of these cases suggests that the development of the ectopic ACTH syndrome may reflect changes in cell populations within the tumor and/or alterations in tumor behavior with time and perhaps with the effects of drug therapy.


Tumor resection was performed, with posterolateral fusion and spinal instrumentation.


There was a good correlation between the total dose of ACTH and the percentage decrease of brain parenchyma.


Transthoracic echocardiography showed a mass in the LA.


He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.


The difference between infliximab and etanercept in viral reactivation may be linked to the pharmacologic difference of each medication.


Reserpine was administered specifically for hypertension in 91.3 percent of patients; 35.5 per cent of patients received the drug by intramuscular (IM) injection.


This organism has rapidly spread through many countries.


Hypoglycaemic coma recurred.


Remission was confirmed objectively with pure-tone audiometry.


There was complete radiological and clinical resolution of the abscess on prolonged treatment with amphotericin alone.


Further investigation excluded malignancy.


Previously noted abnormal signal intensities have nearly disappreared on follow-up MRI obtained on the 22nd day after the first seizure.


Nocardiosis in a patient with primary anti-phospholipid syndrome.


Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%).


Thymic hyperplasia can occur after cytotoxic therapy for various malignancies.


We describe 2 patients with prior amputation who experienced phantom limb pain (PLP) after receiving paclitaxel therapy.


Fungal infections are rare but represent serious complications following organ transplantation.