METHODS: The patient was a 20-year-old woman.


In addition to its antiviral action, ribavirin also enhances the Th1 response.


SIADH appeared to be transient and asymptomatic in our patients.


The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.


She was admitted to the hospital for persistent vomiting.


Acute transverse myelitis is an acute inflammatory process of the spinal cord and it is a rare clinical syndrome in childhood.


In addition, this case underscores the importance of communication between physician and patient and the resulting toxicity related to miscommunication.


The fluorine contained in niflumic acid induced a marked densification of trabecular bone in all 3 cases.


The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.


Clinical evidence of vena cava thrombosis and associated spontaneous intraventricular hemorrhage developed on Day 24 and 36, respectively, and these findings were confirmed on imaging studies.


This entity should be added to the group of conditions, both infectious and noninfectious, that cause diffuse pulmonary uptake on labeled leukocyte images.


A case report is presented of a bulimic patient with manic symptoms who was successfully treated with lithium.


METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.


Pain partially responsive to opioids can lead to rapid escalating dosages due to tolerance development.


With the diagnosis of therapy-related acute myeloid leukemia (AML) secured, he began induction chemotherapy with idarubicin and cytarabine.


Following removal of a large right adrenal carcinoma, serum and urinary hormone levels returned to normal.


Despite extensive surveillance, an infectious cause for the heart failure was not found while he was alive.


Two of the patients (1 and 3) are from a multicentre trial of adjuvant chemotherapy for gastric carcinoma.


Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors.


Sirolimus (rapamycin) and everolimus are immunosuppressive agents that inhibit cardiac allograft vasculopathy.


A chest X ray showed infiltrates in right upper lobe with bilateral pleural effusion.


Three demented patients who manifested an aggressive syndrome and motor disturbances including agitation, pacing, and restlessness received a therapeutic trial of the antiandrogen agents medroxyprogesterone acetate and luprolide acetate.


Previously reported cases are reviewed.


Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.


The aim of this phase I study was to determine the toxicity profile and the optimal dosage of KW-2149.


Esophageal spasm is an infrequent complication of beta-adrenergic over-dose.


This case presents a patient with neuropathic pain in a lower extremity, which appeared subsequent to the removal of a C1 meningioma and which was successfully treated by lower thoracic spinal cord stimulation.


This case is reminiscent of pneumonitis to other beta-blockers, which are reviewed here.


Fever in dialysis patients with recently rejected renal allografts.


Vital signs were within normal limits.


RESULTS: We found a slightly reduced visual acuity, a slowly increasing amount of yellow-white deposits on the posterior surface of the cornea and on the anterior part of the lens, a normal fundus appearance, and normal visual fields.


Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy.


Disseminated salmonellosis in a patient treated with temozolomide.


Hyperglycemia induced by the first product improved after the substitution, suggesting that the Erwinia enzyme may be less diabetogenic than the E. coli enzyme.


Aspiration of bone marrow with use of clot sections is a minimally invasive, sensitive, and rapid means of detecting granulomatous infection in such febrile immunosuppressed hosts.


Thirteen patients highly allergic to mechlorethamine hydrochloride showed no cross-sensitivity to nitrosourea compounds.


Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.


Since carbamazepine was discontinued and had been prescribed for bipolar disorder, his olanzapine dosage was increased, and trazodone was added at bedtime for insomnia.


The break was successfully closed with an intraoperative injection of Healon5 into the bleb.


Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.


A successful clinical outcome was achieved upon recognition of the fungal pathogen.


The disk diffusion method showed that this Norcardia sp. was sensitive to many antibiotics.


After one fall, the patient became delirious.


The infection was successfully treated with flap amputation and daily debridement in addition to antifungal therapy.


Asthma is a chronic inflammatory condition of the airway, characterised by the presence of airflow obstruction which is variable over short periods of time, or is reversible with treatment.


The incidence of cerebellar toxicity approaches 30 percent, with irreversible ataxia reported in up to 16.7 percent.


We describe a 20-year-old woman who presented with polyarthralgia and sensory neuropathy, including mental nerve neuropathy.


Possible long-term teratogenic effect of isotretinoin in pregnancy.


Aripiprazole combined with low-dose clozapine as maintenance therapy resulted in a positive clinical outcome despite a clozapine serum level that is generally considered subtherapeutic.


CONCLUSIONS: Clinicians should be aware that removing a serotonin-2a (S-HT2a) antagonist 1mm a treatment regimen including an agent that increases serotonin in the synaptic cleft may worsen clozapine withdrawal or potentially result in serious adverse drug reactions, such as serotonin syndrome.


Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).


We encountered two girls with acute promyelocytic leukemia (APL) after living donor partial orthotopic liver transplantation.


Therefore, preventive measures should be taken against colonization by Candida of the palatal mucosa and the dentures.


CONCLUSIONS: Prolonged exposure to itraconazole, administered either continuously or intermittently, may precipitate severe and irreversible hepatotoxic events.


Pyomyositis was completely resolved following the surgical drainage and the antistaphylococcal antibiotic treatment.


Acute pancreatitis after long-term 5-aminosalicylic acid therapy.


No objective data have been presented examining this issue.


When the patient presented to our service he was taking NVP, zidovudine, and lamivudine.


OBJECTIVES: To describe the clinicopathologic features of 3 patients with CML who rapidly progressed from chronic phase to blast crisis while taking imatinib and to perform a review of the literature.


The leukemia developed from 21 to 58 months (median 50 months) after the institution of chemotherapy.


The advent of small-incision surgery has likely reduced the incidence of this complication to low levels.


After excluding other causes of long QT syndrome, the HCQ was suspected as the cause of her ventricular tachycardia.


Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.


Laboratory studies showed elevated creatine kinase, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase levels, as well as azotemia, hyperphosphatemia, hypocalcemia, and leukocytosis.


Abnormal behaviour consisted of elevated mood, euphoria, and increased energy in both patients, and pressure of speech and decreased need for sleep in one of them.


Observation of renal biopsy specimens by light microscopy revealed minor glomerular abnormalities.


High-dose methylprednisolone was administered for treatment of the pneumonitis.


Normal pregnancy after curative multiagent chemotherapy for choriocarcinoma with brain metastases.


METHODS: Exploratory surgery was performed to remove the mass, and histologic and microbiologic studies were conducted.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Percutaneous transluminal coronary angioplasty (PTCA) was complicated by acute coronary artery occlusion associated with ST elevation and severe chest pain in three patients.


Further studies need to be carried out to clarify the pharmacologic differences between dual and selective 5-HT and norepinephrine reuptake inhibitors on lower urinary tract function.


Her initial clinical presentation suggested postoperative infection, but the inflammation continued to progress despite antimicrobial therapy.


Antibodies for HIT by enzyme-linked immunosorbent assay were positive.


She was treated with 50 mg of intravenous thiamine.


METHODS: A case-note audit of all Christchurch Hospital patients with RA prescribed leflunomide between 2002 and 2006 was performed.


Our protocol might not be as efficacious in patients who are more profoundly immunocompromised, eg, bone marrow allograft recipients.


She had no history suggestive of gastroesophageal reflux, peptic ulcer, or pork allergy, and no vomiting on days when enzymes were not given.


A 39-year-old woman underwent placement of a totally implantable venous access device for chemotherapy to treat a recurrent liposarcoma of the left thigh.


She had received about seventy five units of blood at the start of 2 grams of desferrioxamine with every subsequent blood transfusion.


There was also complete regression of lymphadenomegaly.


Because patients may be unlikely to self-report alternative remedies, health care providers should specifically ask their patients about any alternative treatments they may be taking and should be knowledgeable about their toxicities.


Although the exact cause of her hemorrhagic stroke is uncertain, the hypertensive response that may have led to the hemorrhagic stroke occurred following administration of commonly used doses of vasopressor agents.


Post-transplant lymphoproliferative disorder (PTLD) in the central nervous system (CNS) has a poor prognosis.


In all three patients a decrease in anti-DNA antibody levels and an increase in total complement hemolytic activity were detected after therapy.


Many thoracic specialists and eye care physicians consider these effects rare and readily reversible.


After 2 weeks, the thrombus had disappeared.


We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.


Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.


Clofibrate has been considered to be a relatively safe antidiuretic in the treatment of diabetes insipidus.


Fatal long-term immunosuppressive therapy with uncontrolled repeat prescription.


BACKGROUND: Hydroxychloroquine (HCQ) is used for treatment of lupus erythematosus.


METHODS: A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops.


Indirect assessment of endogenous TRH reserve capacity was consistent with impairment of endogenous TRH activity.


Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.


At first, these symptoms were thought to be related to the drug's antipsychotic effect.


Stool specimen was streaked with blood.


Prolonged perioperative antibiotic prophylaxis is mandatory.


Hydroxyurea is a drug widely used to control myeloproliferative disorders, due in part to its relative lack of severe side effects.


We postulate that ITB withdrawal may be a form of serotonergic syndrome that occurs from loss of gamma-aminobutyric acid B receptor-mediated presynaptic inhibition of serotonin.


Parathyroid hormone and calcitonin levels were measured along with phosphate clearance and the tubular reabsorption of phosphate.


Mammary gigantism and D-penicillamine.


Treatment consisted of supportive therapy and intravenous administration of methylene blue.


We observed intracranial hemorrhagic infarcts with focal seizures and hemiparesis associated with clotting abnormalities, including severe hypofibrinogenemia, probably the result of L-asparaginase administered during induction therapy of acute lymphocytic leukemia.


No relapse of endocarditis was observed after 12 months of follow-up.


Her liver displayed reduced volume and there was a mild accumulation of ascitic fluid in the retroperitoneal cavity.


Naloxone may be an important adjunct to therapy.


A patient experienced an organic affective psychosis on three separate occasions after taking recommended doses of non-prescription cold/sinus preparations.


Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.


This case is similar to four other cases described in the literature and to the neuroleptic malignant syndrome.


We report an unusual case of development of upper eyelid depigmentation in a child 4 months following corticosteroid injection of a periocular capillary hemangioma.


Aortic transgraft hemorrhage after systemic thrombolytic therapy.


Results are discussed in light of the existing literature.


Few reports have described dermatologic adverse effects such as rash and pruritus, and, to our knowledge, none have discussed the seriousness or extensiveness of the rash.


Of 877 patients with Crohn's disease, 484 (55. 1%) received corticosteroids during the course of the disease, 196 (22.4%) received at least one course of parenteral nutrition, and 125 (14.3%) received both corticosteroids and parenteral nutrition.


In addition, the mother drew large volumes of blood from the patient under the pretense of following a physician's orders.


Three days later, the patient returned to the emergency department with fever, vomiting, decreased energy and appetitie, and suprapubic abdominal pain, and he was hospitalized.


The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.


The potential for a variety of local and systemic side effects from the use of potent topical corticosteroids has long been recognized.


We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.


This case report presents the clinical and radiographic course of temporomandibular joint (TMJ) involvement in a patient with severe TMJ symptoms from psoriatic arthritis (PsA) resistant to both systemic infliximab and intra-articular glucocorticoid and who therefore received multiple intra-articular infliximab injections for 36 weeks.


We describe a retrospective case series of three patients, two with bipolar depression and one with unipolar depression.


Renal biopsy three weeks after the onset of renal failure revealed evidence of focal renal cortical necrosis.


Although it is considered safe in this context, several reports of short lasting proarrythmic effects have been described.


Useful interventional thrombolytic and anticoagulant therapy for thrombosis due to embolization (TAE) in Budd-Chiari syndrome.


In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.


Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.


The catheter in the pulmonary trunk was successfully removed through a percutaneous femoral vein approach using a pigtail catheter and goose neck snare.


Therapeutic control was reestablished in both patients after therapy with the original levothyroxine product was reinstated.


The patient responded promptly to appropriate antibiotics.


One 13-year-old boy with life-threatening systemic disease experienced a partial remission of disease and tolerated a decrease in prednisone dose from 15 to 4 mg daily following 14 exchanges with FFP.


Urinalysis revealed eosinophils, and a subsequent renal biopsy confirmed a diagnosis of AIN.


A case report.


A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.


Two workers from the same factory presented to the same emergency department within six weeks of one another with moderate (Case 1) and severe (Case 2) methemoglobinemia.


Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.


METHOD: To address the gap in knowledge, we present 2 case reports of patients with early NMS-like symptoms.


Recovery was characterized by the gradual clearing of the pulmonary infiltrates and a gradual lessening of the severe restrictive ventilatory defects over many weeks.


So he underwent surgical treatment.


Medical myths occur for many different reasons.


Unintentional overdose of analgesia secondary to acute dental pain.


We report two cases of severe, acute myopathy with selective degeneration of myosin filaments in asthmatics who developed respiratory failure with hypercapnia and acidosis requiring endotracheal intubation, administration of vecuronium and prolonged ventilatory support.


Choroidal detachment was diagnosed clinically and confirmed by echography.


CONCLUSION: Progressive outer retinal necrosis is not limited to the acquired immunodeficiency syndrome but may occur in patients immunocompromised because of other conditions.


Levetiracetam may be used for maintenance antiepileptic therapy after diazepam administration.


Granulomatous reactions to permanent cosmetic tattoos successfully treated with topical steroids and allopurinol.


Oral corticotherapy combined with low-dose interferon-alpha2a halted disease progression.


The events occurred approximately 10 days after the start of each chemotherapy course.


There have been anecdotal reports of septal perforation in patients with rhinitis on intranasal corticosteroids but hitherto not in patients with ABPA.


We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field.


Hypersensitivity reactions to cisplatin following multiple uncomplicated courses: a report on two cases.


A new complication of cyclophosphamide, methotrexate, and 5-fluorouracil therapy.


Controversy concerning the nephrotoxicity of lithium is discussed, and recommendations for the evaluation of renal failure during lithium therapy are provided.


Echocardiography demonstrated a complete systolic obliteration of the left ventricular cavity.


METHODS: The central and peripheral fields were examined with the Humphrey Visual Field Analyzer.


Enzymes derived from two different bacterial sources (Escherichia coli and Erwinia carotovora) are in common use.


Transient, nonpigmenting fixed drug eruption caused by radiopaque contrast media.


A 3-year-old, 10.9-kg girl was admitted to the pediatric intensive care unit with the diagnosis of dilated cardiomyopathy and acute decompensated heart failure.


We report the successful treatment of Staphylococcus aureus endocarditis in a renal transplant recipient with preservation of his renal allograft.


Infective endocarditis was diagnosed by Duke's Criteria (Durack et al.


Biopsy of mediastinal lymphadenopathy revealed noncaseating granuloma.


Co-trimoxazole was also being administered for prophylaxis against Pneumocystis carinii infection.


CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.


The possible development of a drug-induced vasculitis or lupus-like syndrome should be added to the list of rare toxic effects of vancomycin.


This unusual cause of mental nerve neuropathy has not been previously described.


RESULTS: Four patients had high intraocular pressure after intravitreal ranibizumab 0.5 mg.


The etiologies of the osteonecrosis in our study included corticosteroid therapy, sickle cell disease and one case of idiopathic osteonecrosis.


The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.


To optimize blood pressure control, the antihypertensive medication of a 76-year-old hypertensive female patient was changed from the angiotensin II receptor antagonist irbesartan to aliskiren.


When the seizures were controlled with midazolam, the hypotension subsided and norepinephrine was decreased.


Histologically, these defects appear as osteoid-like niches in the developing dentin which alter the overlying enamel.


Tardive oculogyric crisis (OGC) is a dystonic syndrome that starts after long-term use of dopamine receptor antagonists.


Clostridia are anaerobic Gram-positive bacilli that can be isolated from the soil and the intestinal tract of humans.


Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.


One patient with systemic lupus erythematosus developed erythema multiforme after taking griseofulvin.


Brugada syndrome (BS) is associated with sudden cardiac death in patients with a structurally normal heart.


Most patients improve after discontinuation of the drug.


Imazalil has been used to treat Alternaria infections of plant materials.


Analysis of the PCR products revealed sequences sharing close homology with the coxsackie B-like group of enteroviruses.


The patient was then treated with sertraline without experiencing any incontinence episodes.


Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.


Chronic hiccups is a rare occurrence but can be debilitating for the patient.


This patient developed severe lipoatrophy with the use of a premixed insulin containing the analogue insulin aspart.


Unfortunately, neuroleptic sensitivity in these patients limits effective pharmacological management of these symptoms.


An Enterobacter species was cultured from an intraoperative swab.


Most interestingly, the evolution of NS paralleled the evolution of cGVHD in all patients.


Although the transthoracic echocardiography did not reveal an intra-atrial thrombus, cardioembolism due to disintegration of a pre-existing thrombus was thought to be the underlying mechanism because the patient had atrial fibrillation.


Hypothyroid goiter is a rare but well recognized complication following long term administration of iodine containing expectorants and disinfectants in children.


Neisseria sicca peritonitis in a patient maintained on chronic peritoneal dialysis.


OBJECTIVE: We report a patient who developed neutropenia on clozapine, but behind the cell count decrease showed to be a diurnal variation of the white blood cells (WBC).


New data on lithium and haloperidol incompatibility.


A 32 year-old woman developed generalised lichenoid eruptions on her body followed by diffuse loss of scalp hair of the anagen effluvium type.


Further prospective studies should examine the patterns and prevalence of cannabis use among chronic pain populations.


Pulmonary histopathology demonstrated a mononuclear interstitial infiltrate without evidence of malignant, infectious, granulomatous, or vascular causes.


One patient reacted to glycine in the same way.


BACKGROUND: Orbital cellulitis after strabismus surgery is uncommon, may cause blindness and may lead to death.


Rituximab, a chimeric mouse/human monoclonal antibody that binds to the CD20 antigen, is part of current treatment of many B-cell malignancies and several autoimmune diseases.


To our knowledge, this is the first case of ivermectin-induced severe liver disease published in the literature.


A 42 year old man, treated for testicular carcinoma with combination chemotherapy that included bleomycin, developed life threatening interstitial pneumonitis.


Scant data are available regarding the effect of hemodialysis on the elimination of argatroban.


The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.


Early dialysis in a neonate with intrauterine lisinopril exposure.


Several reports also demonstrated the efficacy of rituximab for the treatment of autoimmune cytopenia, especially for cold agglutinin disease.


It appears that a low dose of mannitol acts as a renal vasodilator while high-dose mannitol is renal vasoconstrictor.


Muscle biopsy showed nonspecific myopathic changes on light microscopy.


Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.


Unusual hypersensitivity to warfarin in a critically ill patient.


Methanol poisoning continues to be a public health problem in Tunisia in spite of the different legislative measures.


Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.


Abemayor).


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


Changes in the parameters of oxygen metabolism in a clinical course recovering from potassium cyanide.


We report the case of a patient who co-ingested a tricyclic antidepressant (2500 mg of doxepin) and a neuroleptic drug (3500 mg of prothipendyl).


Renal insufficiency was present in four patients.


In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.


Long term prognosis in these patients is better as photosensitivity gradually declines with increasing age.


One patient with ineffective erythropoiesis did not have significantly increased hepatic iron stores but responded to the administration of desferrioxamine.


A 64-year-old male with recurrent metastatic squamous cell carcinoma was successfully treated with intensive combination chemotherapy.


This case draws attention to the association of long-term ergot dopamine agonist therapy with pleuropulmonary fibrosis, which can develop as late as 11 years after the initiation of therapy.


Patients with brown recluse spider bites commonly suffer from pain, muscular aching, and a variety of local dysesthesias during the acute and resolution phases of toxin-induced injury.


The clinical activity of sirolimus in PEComa additionally strengthens the pathobiologic similarities linking PEComas to other neoplasms related to the tuberous sclerosis complex.


After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.


STUDY DESIGN: Case reports are presented of three premature infants (mean gestational age 27 weeks) cared for in the intensive care nursery in whom clinically significant septal hypertrophy and left ventricular outflow tract obstruction developed during dexamethasone treatment for bronchopulmonary dysplasia.


He was treated by TACE.


The number of prior transfusions, the hepatic iron content and the serum ferritin levels appear to be useful in predicting which patients will respond to iron chelation therapy, especially if there is little bone marrow erythropoietic activity.


Skin biopsies confirmed scrofuloderma and the patient was successfully treated for tuberculosis with resolution of the brain masses.


Although he survived the acute stages following injury, his pulmonary function subsequently deteriorated with a damaged trachea and bronchi, repeated attacks of pneumonia, atelectasis, pneumothorax and lung fibrosis, leading to death with hypercapnia (PaCO2 more than 100 mmHg) after 205 days in hospital.


Pulmonary GVHD and pulmonary aspergillosis were also observed.


Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report.


Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia.


Clinical and biochemical recovery followed discontinuation of drug therapy.


Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.


Twenty-six months later, the patient is disease-free but continues to require pancreatic enzyme supplements.


Oxcarbazepine-associated angioedema manifested by swelling of the face, eyes, lips, or tongue or difficulty swallowing or breathing (or both) is a rare but potentially life-threatening reaction for which early recognition and management are vital.


We also review the literature on similar cases and on the safety of ECT with muscle relaxation in this condition.


There were small changes in the shape of the P waves and P-R intervals.


Triiodothyronine-induced thyrotoxicosis in ophthalmic Graves disease.


Although an increased incidence of Mycobacterium tuberculosis infection is found in patients after subtotal gastrectomy, to my knowledge, the potential for gastrectomy to alter the course and outcome of typical mycobacterial disease has not been noted.


However, reticulocytes were markedly increased in number on the 13th day of hospitalization.


We propose that hypersexuality on antiparkinsonian drugs is consequent to inhibition of prolactin secretion.


We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal' screening test for adrenal insufficiency, yet had clinical evidence of adrenal failure.


She received induction therapy according to the AML92 protocol of the Japan Adult Leukemia Study Group (JALSG) with all-trans retinoic acid (ATRA) plus chemotherapeutic agents.


The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.


A thyroid scan performed at that time revealed a gland of normal size and texture.


OBJECTIVE: We describe atypical motor and cognitive features in a case of familial Alzheimer disease (FAD) due to presenilin-1 (PS-1) mutation.


Fluorinated topical steroids have been implicated as the cause or precipitating factor in previous case reports mainly involving an adult population.


METHODS: Patients successfully treated with maintenance doses of im gold (< 20 mg/mo and not more than 10 mg/dose) were identified by chart review.


Hypothyroid and hyperthyroid disease are both associated with a variety of muscle abnormalities, from myalgias to myopathy.


BACKGROUND AND OBJECTIVES: Sternal fracture pain is severe and is difficult to alleviate due to the forces acting on the chest wall during respiration.


Careful assessment of all VADs is important to identify complications such as fibrin sheath formation, which can potentially lead to extravasation.


Other potentially related factors included electrolyte abnormalities and prior neurological insult.


A patient is described with polycythemia vera who was taking anticoagulants and developed a spontaneous retropharyngeal hemorrhage after a violent sneezing episode.


We report a case of a patient who developed reactivation Histoplasmosis after receiving anti-TNF-alpha.


Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.


Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.


The presentation PTLD is diverse, including many patients with symptoms of the head and neck, which may make diagnosis difficult.


Quadriplegia due to lead-contaminated opium--case report.


Of the 3 methods of treatment used, the pars plana anterior vitrectomy approach seemed the most effective and the medical approach with 4% cocaine seemed to be the least predictable.


Ultrastructural study of a renal biopsy in each case showed extensive glomerular epithelial cell foot process fusion.


CONCLUSION: Concentrated epinephrine has the potential for complications when used during endoscopic sinus surgery.


We reported a child with refractory partial seizures successfully managed by clinical desensitization to phenytoin.


CMV antigenemia became negative within 2 weeks and never developed again.


The diagnosis may be made more difficult due to lack of typical allergic symptoms, presence of other drugs, or confounding factors and equivocal noninvasive laboratory studies.


Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.


CASE REPORT: A 27-year-old male presented a corticosteroid-resistant nephrotic syndrome secondary to collapsing FGS corticosteroid.


A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator.


The replies indicate that, at least from the patient's viewpoint, this syndrome occurs frequently.


OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.


The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.


Review of all reported cases of the use of ATRA in pregnancy revealed no serious adverse outcomes or congenital anomalies although only very few cases had exposure in the first trimester.


Known side-effects of salbutamol are described.


Laboratory evaluation revealed a very low serum cortisol level with a concomitantly low-normal level of adrenocorticotropic hormone (corticotropin).


This case demonstrates that although percutaneous retrogasserian phenol injection is a relatively safe and noninvasive method of treatment for trigeminal neuralgia, severe complications may occur.


Severe systemic cytomegalovirus infections in patients with steroid-refractory ulcerative colitis treated by an oral microemulsion form of cyclosporine: report of two cases.


Two children with leukemia developed PTE, the first during the relapse for acute lymphoblastic leukemia and the second at the onset of acute promyelocytic leukemia.


Post radiation sarcoma (malignant fibrous histiocytoma) of the cervical spine following ependymoma (a case report).


After one course of Campath-1H his hematologic parameters normalized, suggesting that the compound may be an effective therapy for complex immunohematologic disorders complicating hematopoietic stem cell transplantation.


Doxorubicin, bleomycin, dacarbazine, and prophylactic pegfilgrastim (a granulocyte colony-stimulating factor), were administered.


Nocardia brain abscess is a rare condition, seen most commonly among immunocompromised patients.


Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.


On the 6th day of chemotherapy, she was in a drowsy state following generalized tonic clonic seizure lasting 20 minutes.


While fluoroscopy is a reliable method for identifying boney structures, ultrasound may identify the vertebral vessels, thyroid gland and vessels, longus coli muscles, nerve roots and the esophagus.


A spinal-cord injury can alter every aspect of a victim's life.


L-asparaginase-provoked seizures as singular expression of central nervous toxicity.


Reversal reactions are caused immunologically by enhanced cell-mediated (Th-1) immunity to Mycobacterium leprae, resulting in inflammation of infected tissues, such as skin and nerves.


Two patients received 6 mg sumatriptan subcutaneously on days 4 and 6, and one patient 3 x 100 mg sumatriptan orally on day 1 after an acute headache episode.


His obstruction resolved, and he remains well at 11 months.


Tamoxifen has been used as a chemotherapeutic agent with no serious side effects noted.


We report the case of a 60-year-old woman who developed erythema and erosions in the axilla and groin while on PLD for breast cancer.


At his last visit, 12 months later, his vision had improved and his serum creatinine was lower, at 2.2 mg/dL.


BACKGROUND: Over the past decade, the treatment of Parkinson disease (PD) has undergone tremendous changes.


This article describes the case of a 25-year-old man found dead at home who had been prescribed olanzapine for schizophrenia.


In conclusion, we were confronted with an unusual case of pheochromocytoma associated with renal artery stenosis and the appearance of watery diarrhea some days after surgical treatment.


High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary.


The pulses consisted of four repeated doses of 500 mg of hydrocortisone given intravenously over 20 to 30 minutes at six-hour intervals or of single intravenous injections of 30 mg/kg of methylprednisolone.


Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.


In patient 4, it occurred several hours after the first ranibizumab injection.


Close examination revealed a cauda equina tumor at the level of L2 and L3.


After treatment, the arterial blood pH rose to 7.53, and vasopressor agents were no longer needed to support blood pressure.


Judging from the patient's course under treatment specific for M. malmoense, the gastrointestinal symptoms were rather manifestations of a chronic relapsing mycobacterial infection.


Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.


Falling backward in two elderly patients taking bupropion.


We describe six patients who developed tardive dyskinesia after treatment with sulpiride for depression or gastrointestinal symptoms.


DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.


Vancomycin (14 mg/mL) was also given twice daily in 2 patients.


The assay had a limit of detection of 0.05 mg/L and an upper limit of linearity of 2 mg/L.


We reported a demonstration case of a 47 year-old female patient with hypersensitivity to anti tuberculosis drugs (isoniazid, rifampicin, pyrazinamid and ethambutol).


Optimizing antithrombotic therapy in patients with non-ST-segment elevation acute coronary syndrome.


Against the advice of her oncologist, she abandoned traditional therapy and started an alternative regimen that included cesium chloride supplements.


Both the skin lesions and the enteropathy respond to gluten restriction.


Cefuroxime-induced acute renal failure.


The authors describe a patient who had a secondary liver infarct during anticoagulant treatment for cerebral infarction.


However, there may be a publication bias in some case reports and studies towards reporting successful rather than unsuccessful CPRs.


Loperamide poisoning in the dog.


The neonatal lamotrigine elimination half-life was approximately twice that seen in adults.


These case reports highlight the potential for anti-CTLA-4-based therapy in previously treated patients with advanced melanoma.


A complete remission was achieved in 96% of children in relapse and in five out of six children resistant to induction.


BACKGROUND: Metformin has been shown to reduce complications and mortality from Type 2 diabetes mellitus, and is increasingly used to treat this condition.


UI resolved after discontinuation of the drug and did not reappear after switching to sertraline therapy.


All 3 patients experienced fairly typical chest pain syndromes and experienced elevations of cardiac enzymes consistent with myocardial ischemia.


Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.


The prognostic significance of this pattern in drug overdose is therefore not definitive by itself.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


This reports presents two cases of hypercontractile heart failure during beta-agonist treatment in very low birthweight (VLBW) infants.


Then, they quickly decreased to 35 and 75% on the 10th day, and 6 months later, they became 16 and <3% of the control, respectively.


CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.


A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.


Oral effects of steroid therapy in a patient with systemic lupus erythematosus: report of case.


This neurocutaneous syndrome consists of angiomatosis of the skin and mucosa as well as the leptomeninges.


Acute GVHD developed at the end of therapy and the patient's leukemia went into remission.


The risk for recurrence in a subsequent pregnancy may be high and should be taken into account in the counseling of parents and in considering drug treatment.


This represents a significant improvement over normal body clearance (4.7 ml/min/kg) in pediatric patients.


In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.


A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder.


The first patient displayed symptoms resembling those of organic brain syndrome which was not associated with a high serum lithium level.


An infection had spread up the right leg, after she had been swimming on holiday in the Canary Islands.


Large infarct size and initiation of anticoagulation after early (less than 12 hours) computed tomography were associated with hemorrhagic transformation and clinical worsening in patients who received anticoagulation therapy.


CONCLUSIONS: The intravitreal ganciclovir implant provides safe and effective therapy against CMV retinitis, and should be considered in patients acquiring the infection after stem cell transplantation.


She received several vasoactive infusions during her admission, including nesiritide.


CONCLUSION: Recent data suggest that eosinophils may directly damage the gastrointestinal tract wall in eosinophilic gastroenteritis.


Cephalosporin-induced leukopenia following rechallenge with cefoxitin.


CONCLUSION: the allergological studies confirmed sensitisation to captopril and tolerance to lisinopril, and enalapril.


Regression of thyrotoxic ophthalmopathy following lithium withdrawal.


A biopsy of the deltoid muscle showed vacuolar degeneration of striated muscle fibers with no inflammatory findings.


Dose deflation of psychotropics was feasible in 35 subjects (74.5%).


The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.


Buphthalmos following systemic steroid treatment.


In none of the patients were any definite clinical, laboratory or morphological signs of an approaching leukaemic transformation of the polycythaemic disorder present.


In two patients with mycosis fungoides, a squamous cell carcinoma developed during therapy with psoralens plus long-wave ultraviolet radiation (PUVA).


Drug provocation test is still a gold standard to establish the diagnosis of hypersensitivity to certain drugs or agents.


A possible tumor necrosis factor-alpha-mediated dedifferentiation of adipocytes.


These cases highlight the importance of considering PTLD in the differential diagnosis of lymphadenopathy and fever post ASCT.


He was started on oral lansoprazole 60 mg twice daily and, on hospital day 2, his platelet count decreased to 102 x 10(3)/mm(3); on hospital day 3, the platelet count was 36 x 10(3)/mm(3).


OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.


In addition, three of the four patients had unusual corneal changes.


Dopamine agonists (DA) have been associated with pathological gambling (PG) and other compulsive behaviors in Parkinson's disease (PD).


This study examines if gadolinium can be removed by frequent exchanges by peritoneal dialysis (PD).


The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental.


Caused by the increasing spreading of angel's trumpet shrubberies in Europe and North America, intoxications with large numbers of fatalities have to be expected in the future.


Acute renal failure (ARF) is an uncommon complication in children with nephrotic syndrome.


Acute spontaneous TLS is rare, and it has been described in leukemia and lymphoma and in some patients with solid tumors prior to institution of therapy.


In three cases, there was a close temporal correlation between the use of a corticosteroid nasal spray and the development of CSC.


Acute coronary events following cisplatin-based chemotherapy.


CONCLUSION: Linezolid seems highly active in combination treatment of MDR-TB.


It is well-recognized that flucloxacillin may occasionally result in fatal hepatic injury.


Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.


In the immunocompetent host, antiviral therapy can successfully treat herpesvirus respiratory infection, with reversal of clinical, virologic, and pathologic findings.


The number of lymphocytes in his peripheral blood, and titres of serum total IgG and IgM and anti-desmoglein1 antibody transiently decreased just before reactivation of HHV-6, cytomegalovirus and Epstein-Barr virus.


METHODS AND RESULTS: This report describes a Merkel cell carcinoma which developed in a liver transplant recipient.


This case illustrates an unusual adverse effect of clonidine.


Little experience exists with this drug in the pediatric population, however.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


An unrelated allogeneic stem cell transplantation was performed.


Other pertinent laboratory data, including liver and renal function tests results, serology for virus infection, and serum levels of vitamin B12 and folic acids, were normal.


These case reports provide evidence that 5-aminosalicylic acid may induce acute pancreatitis after long term treatment.


We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.


Alone or in combination with corticosteroids, cyclosporine is an effective drug of choice for the resistant patients.


We started the subject screening from over 400 patients with Parkinson's disease using strict selection criteria to identify the patients with nocturia who would allow accurate and efficient evaluation of the pergolide effects.


Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.


This case demonstrated the importance of obtaining complete drug histories from patients.


Color Doppler was used to demonstrate a high flow pattern that, unlike in the adult goiter, was associated with hypothyroidism in the neonate.


Recurrent bacteremia developed necessitating Hickman line removal for eventual resolution of the infection.


Due to chloroquine resistance, several African countries have changed their first-line malaria treatment to sulfadoxine-pyrimethamine (SP).


Infection and inflammation in patients on dialysis: an underlying contributor to anemia and epoetin alfa hyporesponse.


Cessation of topiramate caused return of episodes, and the response has persisted for 2 years.


METHOD: A 59-year-old, right-handed man of Caribbean-Hispanic descent underwent brain imaging studies, laboratory tests for AD, and serial neurologic and neuropsychologic evaluations.


Toxic epidermal necrolysis (TEN), or Lyell's syndrome, is a fulminant bullous dermatitis.


A second renal biopsy was performed, which confirmed the diagnosis of acute interstitial nephritis.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


CONCLUSIONS: These results suggest that clozapine may cause TD; however, the prevalence is low and the severity is relatively mild, with no or mild self-reported discomfort.


Prior neurologic illness or CNS insult of any kind is known to increase the vulnerability to neurotoxicity of lithium.


The most common complication of warfarin use is adverse bleeding.


Ultrasound examination confirmed the diagnosis and subsequent resolution of the thrombus.


Many of such strokes are asymptomatic, but some are devastating.


The direct antiglobulin test (DAT) was negative at diagnosis but was found to be positive with anti-IgG after the first fludarabine treatment.


Other corticosteroids of group A, B, C and D were completely negative.


Severe serotonin syndrome induced by mirtazapine monotherapy.


Moreover, young women given vitamin A and tetracycline in combination for acne may be at special risk and should be kept under surveillance.


CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.


Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.


Due to refractory elevations of ICP, high-dose pentobarbital infusion was initiated, and ICP gradually normalised.


The target antigen, cause of the positive direct antiglobulin test (DAT) and mechanism of hemolysis have been the subject of controversy.


Although, we cannot exclude the coincidence between the two diseases we discussed suspicious relationship between the interferon treatment and the tumour progression.


Data on efficacy of late administration of oximes, particularly obidoxime, is limited.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


The patient was heterozygous for the factor V Leiden mutation.


We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.


We report the case of a 54-year old man with decompensated alcoholic liver cirrhosis and HIV infection who underwent liver transplantation (LT).


This report documents the occurrence of severe glomerular pathology associated with continuous, daily antituberculous therapy.


Clinicians should monitor patients receiving this drug for signs of LABD.


Therefore, calcium-channel blockers should be used carefully in peculiar cases of HOCM.


The only positive finding was enlargement of the abdomen without tenderness.


These antiplatelet agents were continued during the perioperative period.


Only 1 death occurred, and most patients (57.5%) had complete resolution of their symptoms within 24 hours of presentation.


Intravitreal antivascular endothelial growth factor (VEGF) drugs are presently being used to treat DME.


This effect was noted to persist throughout the 15-month observation period with no breakthrough dyskinesia.


In the literature, PNH cases also showed neutropenia (0 and 0.54 x 10(9)/l) at aplastic crises.


The diagnosis of ELP was made.


METHODS: We report the case of a 20-year-old male patient with septo-optic dysplasia, fixed cranial diabetes insipidus (DI) and an abnormal thirst threshold.


Immunoprecipitation and Western blot analysis were then used to demonstrate that the aberrant DPD mRNA is translated into a nonfunctional DPD protein that is ubiquitinated.


However, the chlorpromazine equivalent dose of antipsychotics and the number of total psychotropics were significantly reduced from 957 to 722 mg/day (p<0.0001) and from 4.0 to 3.2 (p<0.0001), respectively.


This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.


She was diagnosed with Epstein-Barr virus-associated polymorphic lymphoproliferative disorder (LPD) due to immunodeficiency caused by MTX administration.


The patient remained constantly HIV negative during 14 months of follow-up.


The infection ultimately cleared in all eyes with topical therapy using chlorhexidine, propamidine, and antibiotic ointment with neomycin.


We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.


A case report of a three kilogram, four month infant who received excessive doses of chloramphenicol for the treatment of bacterial meningitis is presented.


Inflammation may be a component of TiACG.


CONCLUSION: Despite extremely delayed presentation, aggressive CDT was successful in both breast, and head and neck reconstructions with excellent long-term flap results.


This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.


Case report.


Effect of o,p'-DDD on serum and urinary androgens.


The QT interval must be measured on the ECG in patients with unexplained seizures; "supraventricular tachycardia with aberration" is uncommon in children.


Thrombolytic treatment is advocated for critical patients unless emergency institution of cardio pulmonary bypass is required and/or indicated.


Hypokalemia after normal doses of neubulized albuterol (salbutamol).


2-CdA typically causes a long-lasting state of immunodeficiency and the profound influence of this drug on the immune system has raised questions concerning the emergence of secondary neoplasms after its use.


Urethral syndrome: response to alpha-adrenergic blocking agents.


He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.


MK-0457 (VX-680) is a small-molecule aurora kinase (AK) inhibitor with preclinical antileukemia activity.


Three patients who received more than 1100 mg/m2 developed pulmonary symptoms with the same clinical and radiologic pattern as in the two cases with pathologic documents, and two of them died from acute respiratory failure.


The possible mechanisms by which iodine-containing drugs induce thyroid disfunction are reviewed, suggesting this case was caused by an alteration in the sensitivity of the intrinsic autoregulation of the thyroid gland to iodine.


Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.


Dexamethasone levels were measured in the serum by radioimmunoassay and shown to be lowered by o,p'-DDD therapy.


We report a case of Ritalin-associated cataract and glaucoma.


Appropriate methods for sterilizing endoscopes are reviewed, including sterilization with 2.5 per cent glutaraldehyde solution and ethylene oxide gas.


The gold standard for diagnosis is renal biopsy, but it is only rarely performed during the acute phase of the reaction and is not without risk.


Her plasma cesium level was 2400 microg/dl (normal < 1 microg/dl), and her family was told to stop her alternative treatment regimen.


The presence of thrombi in this early-stage lesion suggests that thrombosis plays a role in the initial pathogenesis of this condition.


In order to induce further resorption of the haematoma.


A patient with post-traumatic epilepsy who had remained fit-free for many years until she was given the 5-HT reuptake inhibitor fluvoxamine is reported.


An 88-year-old woman developed necrotizing scleritis after eye muscle surgery.


Because she could not tolerate ketoconazole and was hypersensitive to griseofulvin, she received itraconazole with complete recovery within 30 days.


The literature pertaining to sex hormones and their role in affecting periodontal disease is reviewed.


An electroencephalogram was consistent with the diagnosis of nonconvulsive status epilepticus.


The ACAD is defined as a diffuse process affecting the entire length of epicardial vessels.


To date, reports about the macroscopic appearance of ventriculitis have been rare, consisting only of a few autopsy cases.


It is widely used in rheumatologic diseases, and has a very high efficacy/toxicity ratio.


Extensive osseous tophi, resorbed rapidly during therapy with this xanthine oxidase inhibitor and not replaced by new bone matrix, were responsible for the deformity.


We recommend that the immune status of these patients to varicella-zoster virus be assessed by a serum titer.


The authors report a further case of methimazole-associated liver damage and present a brief review of eleven previous cases found in the literature.


The drug was discontinued, his symptoms resolved, and his liver function tests returned to normal.


Overall, responses occurred in 4 of 17 patients (24%) receiving rhEPO at a dose of 1,200 to 1,600 U/kg intravenously (IV) twice weekly.


Each had angiographically documented bilateral high-grade stenosis or occlusion of the internal carotid arteries.


PURPOSE: Choroidal detachment is a known complication of topical hypotensive agents when used to treat eyes sensitized by prior surgery.


Immunoperfusion with staphylococcal protein A is the most effective treatment available and this new technique appears promising.


We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.


Reye syndrome (RS) is believed to occur infrequently among children receiving long-term aspirin therapy.


During the past 2 years since new legislation for organ transplantation from brain-dead donors came into effect in Japan, 3 cardiac transplants have been carried out, 2 of which were performed at the National Cardiovascular Center (NCVC).


The decedent was also prescribed tramadol, gabapentin, cetirizine, modafinil, carisoprodol, and Xyrem.


The tumor was not adherent to the dura, and its appearance was that of a typical neurilemmoma.


CONCLUSIONS: With increasing clinical use of terlipressin and an increasing incidence of obesity and non-alcoholic fatty liver disease-related cirrhosis, the incidence of these serious complications is likely to rise.


Parkinson disease: an update.


A third patient developed a severe pityrias rosea-like eruption.


Hypercontractile heart failure caused by catecholamine therapy in premature neonates.


This observation supports the notion of a possible pro-epileptogenic effect of opioid substances in association with metabolic and other toxic factors.


One minute after intrathecal injection of 3.5 mL of solution, the patient developed myoclonus of his lower extremities.


This article does not question the efficacy of the V.A.C. technique in the treatment of difficult wounds, but focuses on raising the index of suspicion of toxic shock syndrome in patients with wounds managed with the V.A.C. who develop early signs or symptoms that may be consistent with the diagnosis.


PATIENTS: One patient with mucositis secondary to chemotherapy.


Therefore we had suggested that introducing tacrolimus could be a therapeutic option.


Histopathology revealed differentiated adult Wilms' tumour with renal angiosarcoma, whereas the pathology of the para-aortic lymph node and bone metastasis revealed angiosarcoma only.


We describe the case of a woman so treated with this protocol who subsequently developed severe life threatening laryngeal necrosis.


Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement.


This occurred consecutively after the administration of chemotherapy, during the ensuing period of myelosuppression.


Histological examination of the kidneys showed tubular dysgenesis with poor differentiation of the proximal tubules.


Some hiccups are associated with certain diseases or occur postsurgically, and life-restricting intractable hiccups should be treated.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


Six weeks after PDT, a concentric area of RPE atrophy was clearly visible on fluorescein angiogram.


She was treated by right axillo-femoral bypass, removal of the aortic prosthesis and direct aortic suture.


Chest roentgenogram showed infiltration in the left lung field, and laboratory data revealed eosinophilia.


Report of two cases and concise review of the literature.


Within 4 weeks of the start of the antiandrogen therapy, verbal and physical aggressivity had ceased; activity disturbances such as agitation, pacing, and restlessness were markedly reduced.


Methotrexate (MTX) is a commonly used second line agent for RA, and there have been several recent reports of Epstein-Barr virus (EBV)-associated polyclonal B cell lymphoproliferative disorder in MTX-treated RA patients.


However, it was rarely reported in ECT sessions for psychiatric patients who needed concurrent antibiotic treatments.


Four dogs developed cutaneous lesions following the administration of various antibiotics.


RESULTS: The combination of these drugs, even small doses, caused toxicity.


CONCLUSION: In conclusion, because of increased lymphoid malignancy risk, ovarian masses in JRA patients should be carefully evaluated.


Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.


With initiation of treatment, her pulmonary symptoms and radiographic and spirometric evidence of BO resolved.


A 36-year-old man with AIDS and relapsing, nonproductive cough.


Only mild pericellular fibrosis was present in the liver biopsy specimen obtained shortly after abstinence, but after 5 years the second liver biopsy showed that thin septum-like fibrosis that formed portal-to-portal and portal-to-central linkage had developed and ground-glass hepatocytes had emerged extensively.


We report an unusual case of catheter fracture as a consequence of pinchoff syndrome, and discuss the potential methods to avoid this complication and its evolution.


In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.


Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.


Subsequent joint aspiration revealed monosodium urate monohydrate crystals.


The membranes resolved and visual acuity improved with topical corticosteroid treatment alone but recurred in all patients on cessation of treatment.


RESULTS: Two weeks after treatment of the injury with botulinum toxin, the patient reported complete resolution of his symptoms.


By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.


On day 28 of the treatment, his serum calcium levels had reached 3.55 mmol/l, and his urinary calcium excretion had also increased from 0.008 g/day to 0.475 g/day.


Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.


PURPOSE: The aim of the study is to describe a case of suspected endotoxin-induced uveitis associated with septic endogenous endophthalmitis followed by antibiotic-induced endotoxemia.


Patient had primary polydipsia and secondarily developed hyponatremia.


One expert would order a CT scan to rule out facial fractures (Dr.


Cyclosporine was discontinued, and plasmapheresis was started.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Small bowel haemorrhage due to cytomegalovirus vasculitis.


Her initial EEG showed a pattern of spindle coma with some responsivity of the background.


Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.


Statins are associated with a small, dose-related risk of myopathy, myositis, and rhabdomyolysis.


We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.


Veno-occlusive disease (VOD) of the liver is mainly described after chemo-irradiation conditioning regimens during haematopoietic stem cell transplantation (SCT) and has been sporadically reported after kidney and liver transplantation.


Neonatal venous cerebral hemorrhage.


Two patients with HLH developed etoposide-related secondary acute myeloid leukemia (sAML) following therapy for HLH.


In association with this tocolysis, urinary calculus of magnesium ammonium phosphate occurred at 34 weeks gestation.


This reaction was considered to fit with coronary vasospasm.


It also shows severe relapse after withdrawal of fenclofenac.


During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully.


With the alarming increase in incidence of tuberculosis in the United States over the past several years a review of anti-tuberculosis medications and their potential side effects is warranted.


In addition, lipid abnormalities (mainly hypertriglyceridaemia) are also found more frequently in hypertensive patients than in normotensives.


OBJECTIVE: To report a patient with a large gastrointestinal stromal tumor (GIST) who received multiple blood transfusions intraoperatively and developed a transfusion-related acute lung injury (TRALI).


The clinical and electrophysiological features of the case are discussed.


CONCLUSIONS: Exposure to vanadium can cause a metal fume fever-like syndrome associated with neutrophilic alveolitis.


Moxalactam is more likely to be associated with platelet dysfunction.


During the first treatment, dysarthria and ataxia were seen after completion of the patient's eighth and final dose of HDARAC.


Successful liver transplantation and treatment of recurrent hepatitis C using pegylated alpha-interferon in a patient with Churg-Strauss disease.


No published reports of priapism with antidepressants were located, but 11 cases have been reported to the manufacturers.


METHODS: Two patients with exudative age-related macular degeneration were treated sequentially with an intravitreal injection of bevacizumab and developed signs of severe but painless infectious endophthalmitis 2 days later.


We conclude that tuberculosis is an important diagnostic consideration for CAPD patients with peritonitis that is refractory to broad-spectrum antibiotics.


CASE PRESENTATION: A 33-month-old girl was diagnosed with CF at 6 months of age.


We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.


Diagnosis of HUS was confirmed histologically in 13 patients and based on clinical findings in the other 15.


Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good results.


Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.


Hyperphosphatemia is an infrequent complication of the tumor lysis following induction therapy for lymphoproliferative disorders that can result in acute renal failure.


That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).


This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.


Since its introduction to the market, there have been various dermatologic side effects reported in the literature, the most well known being hand-foot skin reaction.


Confocal microscopy findings of Acanthamoeba keratitis.


Transient high rates of infusion of Intralipid appears to be a factor in the aetiology of the condition.


Following CaEDTA therapy, continued recovery of conduction velocities, amplitude of compound muscle action potential, and diminution of conduction block at elbow were observed within a few months.


He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.


The patient's serum ammonia level returned to normal by hospital day 4, and he was discharged to his group home.


Attempts at symptom control are not always effective because of lack of clarity about the underlying aetiology.


METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.


The mild immunosuppression that occurs with methotrexate therapy probably places patients with rheumatoid arthritis at added risk of developing lymphoproliferative diseases, but coincidence cannot be excluded.


A fecal fat 72-hour study revealed a coefficient of absorption of 50%.


An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate.


We report of a case of severe disseminated U. urealyticum infection in a 35-y-old kidney transplanted patient with CVID.


Concentric retinal pigment epithelium atrophy after a single photodynamic therapy.


She was found to have high protamine-specific, as well as insulin-specific, IgE levels, and because of her poor response to regular insulin desensitization, she was desensitized to both regular and NPH insulin.


There is no effective monitoring to prevent this side effect.


MRI revealed white matter abnormalities that were not present on the pretreatment scan.


We obtained the following results.


Lymphocytes obtained from a hyperthyroid patient treated with propylthiouracil without complications failed to show evidence of sensitization.


The second is a case of superficial invasion of Candida in a stitch ulcer.


After previously tolerating ECT well, introduction of moxifloxacin for a respiratory tract infection was associated with prolonged seizure duration despite complete resolution of her respiratory complaint.


Although her drowsiness improved, she complained of piloerection throughout her body.


It gives the radiological and CT scan findings and the important role played by them in the diagnosis of this syndrome.


Solid organ transplant recipients can experience serious disease and death from infection due to the parasitic roundworm Strongyloides stercoralis.


Where over-usage occurs a state of diminished airways response seems to result: it is also possible that the convulsions which occurred in one case may be related to such abuse.


No fever, elevated WBC count or significant electrolyte imbalance was found.


Thus, we believe that the combination of sodium thiosulfate with cinacalcet and paracalcitol is effective for the treatment of calciphylaxis with secondary hyperparathyroidism.


A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.


Given the wide use of gemcitabine following chemoradiation for pancreatic cancer, providers should be aware of this potential complication.


One patient underwent coronary angiography which disclosed no pathology, but following which, while on a calcium channel blocking agent regimen, he had an uneventful course of chemotherapy with cisplatin.


The relation of TNF-alpha antagonist therapy to demyelinating disease/multiple sclerosis is explored.


A hypertensive women was treated throughout pregnancy with propranolol 40 mg daily without complication.


METHODS: An 8-year-old boy with osteomyelitis was referred due to visual disturbance.


The patient was successfully treated with prednisone 1 mg/kg/day for 2 weeks.


Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.


Eight of the patients required chelation therapy.


In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.


We describe the first published case of intoxication with both drugs.


Management consisted of supportive care including antibiotics and antifungal therapy, transfusion of red blood cells and fresh frozen plasma.


In the case of atypical neuroleptics such as olanzapine a low but still considerable D2 dopamine receptor occupancy may be compensated by the 5-HT2 antagonism.


As nonallergic increases in tryptase have been observed, e.g. during angio-oedema from angiotensin-converting enzyme inhibitors, and bradykinin itself can degranulate mast cells acutely, we interpret the reaction as a class effect.


OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.


We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.


Cerebral blood flow and blood pressure monitoring, together with intensive antihypertensive therapy, are necessary to reduce the risk of hyperperfusion syndrome after vertebral stenting.


Our study also suggests that switching from bromocriptine to pergolide improves nocturia, thereby improving sleep status of patients with Parkinson's disease.


Oral pilocarpine tablets, as well as another muscarinic agent (cevimeline), have recently been approved for the treatment of dry mouth (xerostomia).


The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases.


The co-occurrence of bingeing, irritability and anterograde amnesia is suggestive of a drug-induced Kleine-Levin Syndrome.


Although not previously known, it was at this stage discovered that the patient had received treatment with anti-leprosy drugs nearly three years before presentation in this country.


All three cases showed extensive fibrin deposition in the kidneys and lungs, the appearances of the renal lesions being similar to those seen in the haemolytic-uraemic syndrome.


This case illustrates a successful treatment of BO with selective tumor necrosis factor-alpha blockade.


Kalimate was administered orally and as an enema suspended in 20% dextrose water to treat hyperkalemia.


The visual loss in this patient seems to result from phenol neurotoxicity rather than mechanical compression of the intraorbital optic nerve.


Zolpidem tissue concentrations in a multiple drug related death involving Ambien.


Dementia affects up to 70% of nursing-home patients, and more than 90% of them exhibit aggressive or agitated behavior or severe depression.


We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.


Prompt hemostasis was achieved in half of the patients with their coagulation profile being restored within 4 hours after the administration of the first dose of rFVIIa.


These results indicate that CFSE dilution assay will be useful for the diagnosis and monitoring of drug hypersensitivity.


She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.


Clearly, patience is important during hepatitis C therapy in order to avoid unnecessary examinations and to promote successful outcomes.


Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.


Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.


Despite treatment in the intensive care unit, the woman died on the sixth day after admission.


Though the voluntary recall was in effect, the family already had a bottle of the medication at home.


Despite withdrawal of antiretroviral therapy a proximal myopathy developed.


Inflammation may be exacerbated by pre-existing dermatologic conditions.


PURPOSE: Standard therapy of mycotic aneurysms in the descending aorta consists of thoracotomy and in situ graft placement or extraanatomic bypass.


PURPOSE: The aim of this article was to review the most important data in the literature about SSEH and to propose clopidogrel (Plavix) therapy as a risk factor.


Effective treatment includes daily oral hygiene and periodic professional prophylaxis.


One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).


There have been few reports on the imaging diagnosis and treatment of infection of interbody cages used in posterior lumbar interbody fusion.


After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.


Treprostinil is labeled for treatment of pulmonary hypertension with New York Heart Association (NYHA) Class II, III and IV symptoms.


Neuroleptic drug induced downregulation of nigral dopaminergic neurons may help to explain the persistent parkinsonism found in many patients after withdrawal of medication.


The atypical antipsychotics have advanced the treatment of schizophrenia and have proved to be effective agents in treating other disorders with or without psychotic features.


Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab.


Neurologic symptoms were usually absent, but 49% of the patients developed adult respiratory distress syndrome (ARDS).


Thus, further therapy must not be withheld.


RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.


Allergic contact and photocontact dermatitis due to psoralens in patients with psoriasis treated with topical PUVA.


Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.


We present a patient who developed skin lesions typical of disseminated superficial porokeratosis (DSP) while on immunosuppressive therapy for pemphigus foliaceus.


Severe autologous GVHD after hematopoietic progenitor cell transplantation for multiple myeloma.


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


Amantadine was therefore discontinued.


The case is presented of a 39-year-old Type 1 diabetic patient of 22 years duration with recurrent hypoglycaemic comas.


Miconazole as a treatment for Candida septicaemia.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity.


Diarrhea-associated over-anticoagulation in a patient taking warfarin: therapeutic role of cholestyramine.


In more than 6,000 patient applications of rapid atrial pacing, there has been only one failure to convert the tachycardia.


Moderate lymphocytic infiltration of the substantia propria of the conjunctiva of both upper and lower lid specimens was present, as was scarring and keratinization of the epithelium.


This article presents a rare case of acute toxic hepatitis in thirty-one-year old primigravida.


Catatonia associated with disulfiram therapy.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


CONCLUSIONS: Intravitreal injection of triamcinolone acetonide may be an additional tool in the treatment of therapy-resistant cystoid macular edema after penetrating keratoplasty.


The operation was accomplished with cardiopulmonary bypass.


Idiosyncratic pulmonary reactions to nitrofurantoin are not unusual, often presenting as eosinophilic pneumonia.


Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.


BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.


We report three cases of post-transplant lymphoproliferative disorder (PTLD) in the context of autologous stem cell transplantation (ASCT) for multiple myeloma (MM) and non-Hodgkin's lymphoma.


A fifty-six year old black man with stage D carcinoma of the prostate was treated weekly with 5-fluorouracil 750 mg/m2 for twenty-four consecutive doses.


Acute myeloid leukaemia with t(8;16)(p11;p13) in a child after intrauterine X-ray exposure.


Moreover, meningiomas in the lumbosacral region are very rare.


Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C.


A 40-year-old man with advanced HIV infection and Mycobacterium avium complex infection experienced rapid cognitive decline after commencement of ethambutol, and symptoms fully resolved with cessation.


Individual pharmacokinetics were assessed using Bayesian analysis.


Although the current metabolism of the 2 drugs in combination is poorly understood, the potential for serious interactions seems to exist in the rapidly growing population of persons with asthma, for whom they may be prescribed.


After admission, he was found to have retrograde shunt infection from peritonitis caused by cholecystitis.


All patients improved and 6 are in complete remission.


RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.


Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.