A 2-year-old boy with type I diabetes mellitus was admitted due to a coma caused by cerebral oedema and was successfully treated for his neurological condition but presented on the tenth day after admission with fever of 40 degrees C, agitation, restlessness, lack of appetite, somnolence and fatigue.


There was serological evidence of a recent Group A streptococcal infection.


Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).


These findings suggested vasospasm or dissection, presumably related to hypertension and/or angiitis or vasoconstriction of large cerebral arteries leading to local thrombosis as a result of stasis and sympathomimetic-induced platelet activation.


Concomitant administration of estradiol resulted in a reduction in serum alanine aminotransferase and ferritin levels and hepatic iron concentration and staining after 2 years of estrogen therapy, although interferon therapy was withdrawn because of adverse effects.


Physical examination findings were consistent with congestive heart failure.


The observed serum ceruloplasmin response after parenteral copper administration is suggestive of an impairment in the incorporation of copper into this metalloprotein.


These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.


CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.


In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.


The patient suffered a life-threatening anaphylactoid reaction to amifostine.


The manner of death was determined to be accidental.


CASE: A 58-year-old Caucasian woman was referred to our hospital for chronic unilateral granulomatous panuveitis of the right eye (RE).


CONCLUSIONS: The increase in Accutane use observed among females may be exacerbated by advertising.


A pulmonary artery catheter with the capacity to measure cardiac output and mixed venous oxygen saturation (SvO2) continuously was used.


We describe a 24-year-old man who developed minimal change nephrotic syndrome after allogenic hematopoietic stem cell transplantation (HSCT).


The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).


Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist.


This deleterious association, if verified, has important implications for the treatment of AMI in patients who have RA and are corticosteroid dependent.


Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.


Toxicity was mainly hematological and of acceptable degree.


In addition, the optimized use of new technologies designed to augment spontaneous breathing efforts by patients, mechanical ventilation, as well as the advantages of early tracheotomy will contribute to better outcomes in the treatment of respiratory failure due to pulmonary mycoses following allogeneic HSCT.


The twelve-lead ECG exhibited a coved type ST-segment elevation in leads V(1) and V(2), and their enhancement was induced by pilsicainide.


UFT has been used in Japan, other Asian countries, South America, and Russia.


Severe neurotoxicity with methyl G: CALGB experience.


Iodine-induced hypothyroidism and goiter following lipiodolTM lymphography.


Biologic therapy with tumor necrosis factor (TNF)-alpha antagonists for rheumatoid arthritis has been well established.


However, these drugs contain side effects.


Severe autologous GVHD occurred only in patients transplanted for multiple myeloma and was observed at a much higher frequency in patients undergoing their second HPCT.


Our review also indicates that impairment of neonatal thyroid function may be minimized by using a thioamide dose that is just sufficient to maintain the maternal serum free thyroxine concentration in the high normal or slightly thyrotoxic range.


STUDY DESIGN: Harvesting of autologous bone graft from the posterior iliac crest for lumbar spinal fusions is a frequently performed procedure in orthopedic surgery.


He had a similar urticarial rash 1.5 years earlier with this product and was instructed not to use it.


Two patients were found not to be sensitive and started on aspirin, the other had a classic asthmatic reaction to the drug and was successfully desensitized to aspirin allowing for its use.


Tolazoline Hydrochloride is a pulmonary vasodilator that is used for the treatment of pulmonary hypertension of the newborn.


The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.


Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare.


Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids.


Treatment included radiation to the whole brain with a boost to the tumor bed.


Controversy exists over the appropriateness of administering haematopoietic growth factors to healthy individuals.


In both cases propofol was used in bolus doses, and is thought to be the probable factor for its development.


In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association.


After 2 months, her mental status and neurologic status had recovered completely.


Eleven patients presented with congenital hydrocephalus (including 5 with myelomeningocele and 3 with posthemorrhagic hydrocephalus) and 4 with hydrocephalus secondary to central nervous system (CNS) tumors.


The congenital ichthyosiform erythrodermas have become readily treatable with an aromatic retinoid.


Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.


CONCLUSIONS: Fixed drug rash induced by methylphenidate is a possible but rare phenomenon.


Coronary angiography showed dissection of the left anterior descending artery (LAD).


However, the amount of prednisone required to maintain normotension resulted in Cushingoid features and has been discontinued.


Aspergillus fumigatus keratitis is a rare but serious complication of LASIK surgery.


The patient was found comatose and experienced repeated generalized tonic-clonic seizures, aspiration with subsequent pneumonia, hypotension, and an increase in PR interval.


A 73-year-old woman with rheumatoid arthritis had been treated with weekly low-dose methotrexate (MTX) for 5 years.


While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.


This case raises important questions about non-ketotic, hyperosmolar diabetic coma with antipsychotics, the possible association between hyperglycaemia and hyperthermia, and the direction of causality in this, the recognition of either syndrome when they co-exist and management issues in such patients.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


During the management of intracranial hemorrhage, hyperkalemia developed.


There appears to be no reason to advise women receiving propranolol to avoid breast feeding.


The patient was admitted to our hospital due to diabetic ketoacidosis.


This report details a case of bilateral avascular necrosis of the femoral heads in a patient receiving 'standard' doses of dexamethasone as part of the antiemetic regimen used in cisplatin-based combination chemotherapy.


We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.


Management of heparin allergy during pregnancy with danaparoid.


Conventional and diffusion-weighted MRI findings of methotrexate related sub-acute neurotoxicity.


Doctors should be aware of the possible ocular side effects of methylphenidate.


ECM can be easily differentiated from the latter by its typical clinical features.


The present observation suggests, that a batch of different testing doses, including lower testing doses may help to differentiate between an allergic type of contact dermatitis and an irritant type of reaction after treatment with calcipotriol.


Mycophenolate mofetil (MM), an immunosuppressant used after organ transplantation, is also used for treatment of autoimmune myasthenia gravis (MG).


From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).


CONCLUSION: While thrombosis has been reported with GnRH-a therapy in men with prostate cancer, its association with treatment in this benign case may have been a consequence of the massive tumor size.


A 34-year-old woman with a left ovarian cyst (clinically diagnosed as endometrial cyst) was treated with 400 mg of danazol per day.


At that time the area would be debrided and the postauricular skin used for external coverage (Dr.


Atomic absorption analysis showed no significant change in the aluminium content of bone with treatment.


Adverse effects of combined propranolol and chlorpromazine therapy.


Successful treatment with tocainide of recessive generalized congenital myotonia.


Optic disc swelling was resolved on high doses of intravenous steroids.


Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.


We report Kluyvera infections in 2 solid organ transplant recipients.


Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.


Over a period of 3 weeks, the patient became progressively confused and ataxic.


The purpose of this report is to document a new case of in utero CP exposure with multiple congenital anomalies and to establish an apparent CP embryopathy phenotype.


While benign pneumatosis intestinails is a well-known clinical entity, the alarming radiographic findings set off a cascade of clinical angst among many providers.


We conclude that one should be cautious when treating patients with systemic lupus erythematosus and pre-existing renal disease with cyclosporine A especially when tubulointerstitial abnormalities are present and/or other nephrotoxic drugs are used.


Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.


Methylene blue was administered (2 mg/kg intravenously), and the patient rapidly improved.


Lithium carbonate was a useful alternative to neuroleptics in managing the adolescent's disturbed behavior.


In my opinion this reaction is not so uncommon as thought.


The high-intra-articular fluid pressures can force the pyogenic fluid into a pre-existing Baker's cyst.


Due to the costs and risks of standard therapy, we decided to manage the patient supportively.


However, it would be emphasized that the side-effects of the drugs could be considered as one of the etiologica factors causing the glial abnormality.


Salmonella oslo.


This patient, who also had an abdominal aortic aneurysm, survived, on discontinuation of her anticoagulant therapy.


The syndrome is characterized by various gastrointestinal symptoms as well as irritability, diaphoresis and lethargy.


Anaphylaxis is an uncommon but serious complication of anaesthesia.


Measured 25-hydroxyvitamin D (25-OH D) levels were elevated in three patients; levels were not determined in a fourth patient who became normocalcemic when vitamin D therapy was discontinued.


Pre-treatment bone biopsy samples contained extensive osteoid covering trabecular surfaces.


Interaction between tacrolimus and nefazodone in a stable renal transplant recipient.


Of note, the patient had been on carbamazepine therapy one year earlier and had experienced the same adverse event.


Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection.


Rupture of a cerebral aneurysm associated with nifedipine treatment.


Extrapyramidal side effects induced by some selective serotonin reuptake inhibitors (SSRIs), i.e. fluoxetine and sertraline, have been previously reported in patients with depression and obsessive-compulsive disorder (OCD).


Lower extremity arterial thrombosis following sonographically guided thrombin injection of a femoral pseudoaneurysm.


During the final episode, open lung biopsy was performed and demonstrated typical changes of drug-induced pneumonitis, with interstitial infiltrates and fibrosis and proliferation of type II alveolar lining cells.


Torsemide appears to also be a part of a long list of agents that can cause pancreatitis.


We recommend that physicians specifically inquire about patients' use of decongestants and diet aids.


Paraneoplastic systemic sclerosis (SSc) occurs in about 3%-7% of individuals with SSc.


Alternatively, certain viral infections could induce leukopenia.


This reaction is most commonly explained as an adverse effect of numerous medications, such as dopamine receptor blocking agents or neuroleptic medications and traditional antipsychotic or antiemetic drugs, such as prochlorperazine or metoclopramide.


Hence, immunosuppression treatment should be carefully planned in glomerulonephritis treatment and avoided if they are not essentially necessary.


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


This patient has shown that immunosuppression due to splenectomy, NHL, and chemotherapy, especially when using steroids, could be risk factors for pyomyositis in nontropical or semitropical countries.


Elevation of serum creatine kinase during treatment with antithyroid drugs in patients with hyperthyroidism due to Graves disease.


RESULTS: The ratios of alpha(1)-adrenoceptor occupancy by endogenous norepinephrine during the treatment with milnacipran, fluvoxamine and imipramine to that without drug were estimated to be 7.13, 1.00 and 4.12, respectively.


A 10-year-old girl was diagnosed with astrocytoma grade 2.


After immediate administration of antihistamines, the pruritus and papules remitted.


Because the patient did not mention the cosmetic intervention, the diagnosis of polyacrylamide gel-induced granuloma was complicated.


CONCLUSIONS: Photodynamic therapy for cholangiocarcinoma is safe and technically feasible with a preloaded biliary catheter and a monorail technique for catheter positioning.


Intravitreal triamcinolone has been suggested as an adjunctive to photodynamic therapy in the treatment of exudative macular degeneration.


Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.


Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.


He was first treated with intravenous fluids, furosemide and glucocorticoids without significant improvement, but became eucalcemic within 24 hours after receiving a single dose of pamidronate.


The microorganism was identified with a molecular diagnostic method as Schizophyllum commune, which had not been reported in English literature as a pathogen inducing pulmonary nodules after transplantation.


BTX-B has also been shown to be a safe and effective alternative for patients who are resistant to BTX-A.


The anticonvulsant hypersensitivity syndrome (AHS) is an idiosyncratic immunologic reaction to certain anticonvulsant medications, in which internal organ involvement may lead to fatal multisystemic failure.


Trigeminal trophic syndrome (TTS) is an exceedingly rare complication following injury to the trigeminal ganglion, characterized by painless ulcerations, which has only rarely been reported with intraoral features.


The patient was diagnosed and treated for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), a syndrome of fever, rash, and internal organ involvement secondary to medication administration.


A healthy 42 yr-old woman presented with a left keratitis which she had had for 3 months.


Intralesional injection of corticosteroid is widely regarded as the treatment of choice for hemangiomas which induce strabismus or significant refractive error, or occlude the visual axis.


Complete allergy study, including an oral challenge test, should be considered in these patients.


An embolic mechanism of stroke was suspected in this patient, considering the normal results of blood analysis, echocardiogram and cerebral arteriograms.


Five of these patients had an Ahmed shunt implant, 3 had anterior vitrectomy during surgery, and 4 had a soft contact lens in place.


INTERVENTION: Volume resuscitation, vasopressors, high PEEP mechanical ventilation, paralysis, nitric oxide, steroids, rapid albumin infusion.


The catheter was safely removed surgically; pathology examination showed no residual thrombus.


This therapeutic complication has been termed 'fat overloading syndrome' but bears a clinical similarity to post-traumatic fat embolism.


However, side effects and nonresponders to these approaches are not uncommon.


METHODS: Report of a case.


Oral anticoagulant therapy: a precipitating factor in the pathogenesis of cholesterol embolization?


Zolpidem tissue concentrations in a multiple drug related death involving Ambien.


In one patient, karyotypic abnormalities (-5, 7q-) typical of a therapy induced malignancy were associated with rapid progression of a refractory anemia with excess blasts in transformation to an acute non-lymphocytic leukemia.


During the last 15-year period, this atypical antipsychotic agent has been administered to 750 patients managed at the Emergency Psychiatry Services and Clinical Pharmacology Unit of the National Institute of Psychiatry and Neurology (NIPandN; Budapest, Hungary).


Delivery was at term by caesarean section 2 days after spontaneous rupture of membranes and failure to progress in labour.


A computed tomographic (CT) scan confirmed a massive renal tumour associated with extensive retroperitoneal lymph node involvement, bony metastases and a right hip fracture.


On the third post-procedural day, the laboratory results showed increases in his uric acid and potassium levels, which were compatible with a tumor lysis syndrome.


CONCLUSIONS: Patients most commonly affected by ICD, such as pathologic gambling and hypersexuality, are males who develop PD at a younger age, and those with a previous history of mood disorder, alcohol abuse, or obsessive-compulsive disorder.


We report here a case of delirium that occurred after discontinuation of glucocorticoid therapy.


The origin of NIS is outlined briefly and some fundamental clinical and experimental facts are presented, all of which stress the importance of the acute blockade of postsynaptic DA-ergic receptors.


Pregnancy limits the therapeutic options for managing thrombocytopenia which occurs in 5% of patients on heparin.


Hemodialysis was performed in eleven patients (69%) because of visual disturbances and/or metabolic acidosis.


Candida parapsilosis was the causative agent.


METHODS: Cases were identified by using a questionnaire sent to nephrologists and pathologists in French university and general hospitals.


This series of articles facilitated by the Australian Cochrane Musculoskeletal Group (CMSG), aims to place the findings of recent Cochrane musculoskeletal reviews in a context immediately relevant to general practitioners.


CONCLUSIONS: This phenomenon of sudden vitritis after KPro, with few other symptoms and with complete recovery, would be uncharacteristic of a bacterial endophthalmitis.


The patient was successfully treated by anticoagulant therapy.


A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.


We describe a 49-year-old woman who presented in 2002 with pure red cell aplasia (PRCA), systemic lupus erythematosus (SLE), and idiopathic portal hypertension (IPH) that developed following a thymectomy.


Complications were mild and only one child was removed from therapy because of a complication.


Hypoglycaemia did not recur despite continued treatment.


Tacrolimus (FK506)-induced mutism after liver transplant.


Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.


We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.


The authors report a case of severe lactic acidosis in a 3-year-old boy, after 20 days of total parenteral nutrition without vitamin supplementation.


It is associated with localized, sometimes extensive necrosis of the skin.


A fracture of the diffuser tip occurred during 1 of the treatments.


We present a case of carbamazepine intoxication, successfully treated with three hours of high-flux haemodialysis.


Nummular headache: a series with symptomatic and primary cases.


Water-suppressed proton magnetic resonance spectra from a supraventricular volume of central white and gray matter revealed an abnormal lipid signal.


In healthy persons, Candida-induced denture stomatitis is not serious; however, it should be considered a possible spearhead of systemic yeast infections in seriously ill patients, especially in those subjected to prolonged treatment with antibiotics, corticosteroids, or immunosuppressive drugs.


Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.


Effects of pergolide on nocturia in Parkinson's disease: three female cases selected from over 400 patients.


The final diagnosis in each of these patients was drug-induced pneumonitis, which responded to treatment with corticosteroids.


Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer.


Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.


Their past histories were remarkable in that all three had recently undergone chemotherapy for malignancy (2 lymphoma, 1 malignant thymoma).


We present a case of PG arising in the context of DA use for restless legs syndrome.


DESIGN: Observational case report.


CASE SUMMARY: A 45-year-old white man with a history of hypertension and gout was treated with losartan/hydrochlorothiazide, allopurinol, and colchicine.


Both patients were followed carefully for more than a year without the appearance of the resistant virus.


Verapamil may thus improve an inadequate vasodilatatory response of the coronary vascular bed to effort.


Symptoms resolved without consequence 48 hours after discontinuation of venlafaxine.


It helps to reduce the serious toxic side effects of calcineurin inhibitors (CNIs).


A 67-year-old man was admitted for management of a diabetic foot ulcer.


RESULTS: Extensive laboratory investigations failed to yield any diagnosis and allograft nephrectomy was performed in one patient, with a probable diagnosis of inflammation of the allograft, which resulted in no improvement.


Possible drug interaction between warfarin and combination of levamisole and fluorouracil.


It is proposed that neuroleptic-induced dysphoric responses may be responsible for therapeutic failure in some cases of psychotic depression.


Therapy-related CD7+ acute myeloid leukemia with trisomy 8 following acute monocytic leukemia.


90% of the gadolinium was removed from the circulation in 2 days with a regimen of 10-15 exchanges per day of PD.


Significant bleeding from retroperitoneal hematomas is more often associated with major pelvic fractures from high energy blunt force mechanisms, and the blood loss may be tamponaded by the retroperitoneal structures if natural clotting mechanisms are intact.


On histological examination, reddish-purple crystals were identified at frozen section but not in the paraffin sections.


Because recombinant human granulocyte colony-stimulating factor (G-CSF) has been reported to increase the sensitivity of acute myelogenous leukemia (AML) blast cells to cytosine arabinoside (Ara-C) in vitro, we treated a patient with refractory AML with an Ara-C-based regimen in combination with G-CSF (G-CSF/Ara-C therapy).


Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.


Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.


Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.


Urinary incontinence is an important medical condition with clinical and social implications.


This myoclonus is considered to be a new form of spinal reflex myoclonus, because the abdominal myoclonic jerk seems to trigger another myoclonic jerk involving the paraspinal muscles.


Colchicine-induced myopathy in renal failure.


This is the first reported case to our knowledge of successful use of maternal ganciclovir to treat intrauterine CMV infection in a pregnant renal transplant recipient.


In both cases, healing began a few days after moxifloxacin was discontinued, and topical gatifloxacin and corticosteroids were initiated.


Severe allergic reactions, although uncommon, have been reported.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


We propose that the arrhythmias were a complication of steroid pulse therapy.


To the best of our knowledge, this is the first report from Japan about contact dermatitis caused by this medication.


METHOD: Clinical and radiological observations during a rehabilitation program.


Myoclonus is a well-known side effect of anticonvulsant drugs.


No other side-effects were detected.


Sulfasalazine-induced lupus erythematosus.


Postoperative necrotizing scleritis is a rare complication that occurs at the site of previous ocular surgery.


Cushing's syndrome persisted more than 6 months while TCA concentrations remained detectable for at least 80 days.


With continued ganciclovir treatment, the graft remained clear and no recurrence or rejection occurred until 12 months after the last PKP.


In addition to glomerulonephritis and a butterfly rash, previously negative tests for antinuclear, anti-dsDNA and anti-Sm antibodies became positive.


Withdrawal of the medication was associated with return of the patient's normal mental status.


In high-grade tumors, BCG therapy has proven to be superior to intravesical chemotherapy.


OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.


As a direct result of leukocyte imaging, all three underwent fiberoptic bronchoscopy and transbronchial biopsy.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


The incidence of pulmonary nodules after cardiac transplantation is not uncommon, and prompt diagnostic procedures are necessary to minimize disease-related morbidity and mortality.


The use of brimonidine is not recommended in these patients until further data are available.


Her history was remarkable for duodenal ulcer and long-term treatment with a magnesium-aluminum hydroxide antacid (Maalox) and sucralfate.


In five of seven cases, there was a significant visual deterioration following the RPE tear.


Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.


CONCLUSIONS: MMF is a potent immunosuppressive agent in liver transplantation.


PURPOSE: To report a case of Xanthomonas maltophilia endophthalmitis and to increase awareness of its potential as an intraocular pathogen.


In view of our experience in the present case, it should be stressed that close monitoring of coagulation capacity is necessary in critically ill patients in order to avoid fatal haemorrhage after initiating warfarin therapy regardless of the dosage.


Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever.


Immunoglobulin G subclass 2 and 3 deficiencies were the only serologically detectable abnormalities.


Dose and dose intervals should be individualized for optimal benefits and tolerability.


Pelvic dyskinesia with an outstanding response to tetrabenazine.


The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.


At that time, MMI was discontinued and the patient was started on broad-spectrum antibiotics, dexamethasone, and G-CSF.


Fibrin sheath formation around venous access devices (VADs) frequently leads to persistent withdrawal occlusion (PWO).


Thus, an immunological mechanism might be involved in the mechanism of pirmenol-induced QT prolongation and T wave inversion on the electrocardiogram.


A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).


To our knowledge, this is the first report of significant hypotension associated with intravenous valproate in the treatment of status epilepticus in the pediatric population.


Because of her religious faith, the patient was supported without plasma therapy with use of intravenous immunoglobulin, steroids, rituximab, and erythropoietin.


The presumed third case of CAPD-associated peritonitis caused by Listeria monocytogenes is also described.


Follow-up of these infants has shown no recurrence of seizures.


The cases of CBZ-induced SLE reported in the literature were reviewed.


Apart from dose-dependent reversible hemolytic anemia in 1 patient, no severe side effects occurred.


Its evaluation with Doppler ultrasonic velocity detector.


These age-related differences in the pharmacokinetic profile of daptomycin have significant dosing implications.


Lupus erythematosus (LE) and antinuclear antibody (ANA) tests were negative.


Plasma concentrations and response to antidepressants vary considerably between patients treated with similar dosages.


Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.


Catheter-related cutaneous aspergillosis complicated by fungemia and fatal pulmonary infection in an HIV-positive patient with acute lymphocytic leukemia.


In both cases, high fever, skin rash, liver dysfunction and atypical lymphocytosis developed 3 weeks after initiating treatment with SASP.


These studies indicate that rhEPO can be administered safely in very high doses to patients with MDS and that 24% of these patients will respond with increased erythropoiesis.


The recognition of the characteristic features of the syndrome is vital since early aggressive therapy is indicated.


Post mortem examination showed the cause of death to be intestinal infarction resulting from superior mesenteric and portal vein thrombosis.


OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.


The latex of Calotropis procera causes significant ocular morbidity which may be preventable by simple health education.


This syndrome resolved after cessation of pergolide therapy and a switch to pramipexole dihydrochloride.


After surgical resection and extrabeam radiation therapy the patient is alive without evidence of recurrence five years after PEI.


One explanation for the noted increase in the theophylline level is that metabolism occurs mainly by cytochrome P450 (CYP 1A2), an enzyme that is known to be inhibited with high concentrations of zafirlukast.


Our results indicate that pharmacokinetic variability may contribute to either severe myelotoxicity or therapeutic failures.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


METHODS: Imiquimod 5% cream was applied topically once daily, 3 days a week for 8 to 12 weeks, in two patients affected by eyelid nodular basal cell carcinoma.


The introduction of para-aminosalicylic acid (PAS) led to hypoglycaemic coma.


Ocular toxicity by latex of Calotropis procera (Sodom apple).


CCBs should be considered in the treatment of 5-FU or capecitabine-induced headaches.


The authors describe three patients who developed a blue toe syndrome after initiation of oral anticoagulant therapy.


Severe cardiomyopathy following treatment with the tumour necrosis factor-alpha inhibitor adalimumab for Crohn's disease.


Paralysis after transforaminal epidural injection and previous spinal surgery.


Dopamine D2 receptor occupancy 1.5 months after withdrawal still amounted to 83% and 50%.


PATIENTS AND METHODS: Here, we describe the application of this device in two patients with a complicated course of shunt infection.


Three patients showed marked improvement (decrease in VAS, >75%).


CONCLUSIONS: We are unable to explain the exact mechanism of the observed RPE changes; however, they did not lead to loss of visual acuity.


Tardive dyskinesia induced by sulpiride.


Within 24 h of pulse therapy, they complained of palpitations and developed atrial fibrillation which reversed spontaneously or after anti-arrhythmic therapy.


Leflunomide-associated infections in rheumatoid arthritis.


We also review relevant literature regarding incidence and management.


This report is intended to alert others to the possible development of this serious complication following short-term Decadron therapy.


Lower plasma levels of carbamazepine and valproate sodium were observed after 2 days of antineoplastic therapy.


The treatment of patients with human immunodeficiency virus (HIV) infection and hemophilia involves unique challenges that may be addressed with novel antiretroviral classes.


As the use of this drug for off-label indications and in pediatric populations increases, it is important for clinicians to better understand the drug's pharmacokinetic profile in these patient populations.


Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).


The patient required nitroprusside for control of elevated blood pressure.


Purine analogs are effective in the treatment of several chronic lymphoproliferative disorders (CLPD) including hairy cell leukemia (HCL).


The patient was treated with methylprednisolone pulse therapy (1 g/day, for 3 days) followed by oral prednisolone.


INTERPRETATION: Our study highlights clearly that valuable differences between ADR reports from patients and reports from healthcare professionals exist.


METHODS: Case report RESULTS: A patient presented after two weeks of unsuccessful treatment of a corneal ulcer in her right eye.


It is essential to recognize individual susceptibility to neuroleptic-induced side effects for treatment guidelines.


Stricture formation at the level of the calyceal infundibula occurred, as well as retroperitoneal and ureteric fibrosis.


Acute intravenous--intra-arterial revascularization therapy for severe ischemic stroke.


Recurrences of hiccups have responded to increases in baclofen dosage.


In this article, we present the case of a vitiligo patient who was admitted to our facility with an intense burn after the topical use of 8-methoxypsoralen solution as a suntanning agent.


At the same time the elevated plasma oncotic pressure was reduced to normal values.


"Syndrome malin"-like symptoms probably due to interaction between neuroleptica and oral antidiabetic agents.


Small doses of smoked cannabis may improve pain, mood and sleep in some patients with chronic pain.


During intensive care, including steroid-pulse therapy, the patient developed rapidly progressive anemia caused by active bleeding from his small intestine, resulting in resection of 20 cm of ileum.


Retrospective analysis of two cases from 9235 accessioned endometrial biopsies.


The lymphoma presented with pleural effusions, mediastinal and cervical adenopathy, and no gastrointestinal lesion.


We describe a case of a 27-year-old patient whose irritative bladder symptoms showed response to alpha-adrenergic blocking agents on two separate occasions during the course of her treatment.


RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.


This paper contributed to the identification of possible reactions in the oral cavity due to antiretroviral medication.


Patient 1, a 21-month-old boy, started to cough and developed tachypnea, sternal retractions and mild cyanosis immediately after aspiration.


Discontinuation of simvastatin and cyclosporine resulted in resolution of rhabdomyolysis and normalization of renal function.


The symptoms are mainly caused by the space-occupying effect of the large number of cysticerci rather than by adjacent tissue swelling such as is seen in the presence of dying parasites.


The patient recovered without persisting somatic impairment.


PURPOSE: To evaluate the effects of steroid injections for periocular capillary hemangioma on adrenal function and body composition.


RESULTS: The patient skin prick test with commercial calcitonin (Miacalcic. 50 UI/ml) was positive and negative in controls.


Treatment of chromoblastomycosis due to Fonsecaea pedrosoi with low-dose terbinafine.


A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.


Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).


An apparently appropriate dose of intravenous phenytoin was initiated in each case, and the patients were monitored appropriately and given supplemental oxygen.


SETTING: A six-bed pediatric intensive care unit (ICU) at a university hospital.


Pulmonary manifestations of interferon (IFN) use are a rare but well known complication seen with both standard and pegylated interferon alpha-2b (pegIFNalpha-2b) forms of the agent.


Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.


The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.


She was subsequently treated with various hormones to aid in conception and in sustaining pregnancy.


His hospital course was complicated by a non-Q-wave myocardial infarction, for which diltiazem was prescribed.


All patients only required one intravitreal bevacizumab injection to control the neovascularization.


Earlier recognition and treatment may lead to improved outcome.


The authors describe two cases of tardive dyskinesia in which severe axial dystonia and intense facial grimacing produced marked discomfort as well as social and physical disability.


A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.


Fever dropped at least 1.5 degrees C, and heart rate dropped from rates of 120 to 140 to less than 100bpm.


Fatal overdoses associated with quetiapine.


Anti-hypertensive therapy with propranolol during pregnancy and lactation.


Calcium antagonists are drugs commonly prescribed for the treatment of hypertension, angina pectoris, cardiac arrhythmias and other disorders because of their efficacy and tolerability.


Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.


Transarterial embolization given for hepatoma in a patient with Budd-Chiari syndrome resulted in hepatic infarction and inferior vena cava thrombosis.


Contact allergy towards this reagent and 2 of its reaction products was proven by patch tests.


Subsequently, a diagnosis of anticholinergic poisoning was made, based on tachycardia, delirium, dry mucosa, and reduced bowel sounds.


Three patients (mean age, 68.6; range, 64-70 years) had mycotic thoracic aneurysms.


Desensitization to pancreatic enzyme intolerance in a child with cystic fibrosis.


Osteonecrosis in a patient with Crohn's disease unrelated to corticosteroid use.


It is frequently seen on the anterior aspect of the legs of women.


In those patients in whom a reduction in the blood flow to liver tumors was shown angiographically, there was a progressive improvement in hormone secretion and in tumor size in the ensuing year of treatment, suggesting that a major target of SMS is that vascular supply of the tumors.


Due to the potentially life-threatening complications of this condition and the increasing use of anticonvulsants in the treatment of mood disorders, psychiatrists must be aware of the diagnosis and treatment of this condition.


Three cases of angel's trumpet tea-induced psychosis in adolescent substance abusers.


We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.


On the next day, after a total dose of only 600 mg of danazol, gingival bleeding and purpura occurred.


A stage Va B-cell multicentric lymphoma was diagnosed on clinical, cytological (lymph node, bone marrow), histological-immunohistochemical (lymph node excision) and imaging grounds.


Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.


We present three patients with paradoxical seizures; their serum phenytoin levels were 43.5 mcg/mL, 46.5 mcg/mL and 38.3 mcg/mL.


Early diagnosis of leukoencephalopathy of acute lymphocytic leukemia by MRI.


Chest drainage was required to save his life.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.


In 3 patients, leukoencephalopathy was diagnosed by T2-weighted magnetic resonance imaging.


Scleromyxedema is a dermatologic disorder associated with a monoclonal gammopathy and neurologic manifestations.


After infliximab treatment, additional sleep studies revealed an increase in the number of apneic events and SaO2 dips suggesting that TNFalpha plays an important role in the pathophysiology of sleep apnea.


CONCLUSION: Identification of bacteria in blood components should trigger a comprehensive donor evaluation, particularly if donor bacteremia is suspected.


We present the first case of ovarian endometrioid carcinoma and endometriosis in a postmenopausal patient who was treated with tamoxifen for breast cancer.


Liver biopsy showed chronic aggressive hepatitis with subacute hepatic necrosis.


CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.


A report of three cases and a review of the literature.


CASE SUMMARY: A 15-year-old boy of Turkish origin, diagnosed as having FMF at the age of 14 years, was treated with colchicine 1.5 mg/d.


The safety and efficacy of enfuvirtide therapy for HIV infection in patients with hemophilia: a case series.


Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.


Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.


RESULTS: The combination of the two systemic medications resulted in the resolution of the attack with a much more rapid time course than is seen typically for extreme cases of TiACG.


On both occasions the symptoms resolved after treatment.


This process needed cooperation with other lymphoid cells and was abrogated by dexamethasone.


A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption without fever or neutrophilia 7 months after commencing therapy with G-CSF.


Psoriatic arthritis is an inflammatory arthritis associated with psoriasis.


Treatment with ceftriaxone was started before the culture results were obtained, and was continued after susceptibility test results were obtained.


Treatment of cerebrospinal fluid shunt infections commonly involves a combination of intravenous and intraventricular antibiotics.


Diagnosis is made primarily by examination of the stool or intestinal secretions for ova and parasites.


The INR remained subtherapeutic for 5 weeks despite weekly warfarin dose increases.


We report a case of pregnancy in a woman exposed to ATRA during the first trimester.


Coenurosis is a zoonotic disease of humans caused by the larval stage of Taenia (Multiceps) species.


Clinical improvement followed and the wound healed well.


At 12 months there was no evidence of recurrence though new nodular BCCs and SBCCs had developed elsewhere on his upper torso.


This observation illustrates that a coved ST-segment elevation in the right precordial leads should not be, systematically, regarded as a marker of a specific syndrome, but may also reflect a common electrical manifestation of abnormalities in the right ventricle or pericardium.


The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.


It is quite possible that vancomycin was the only culprit, but impossible to ensure with the available evidence.


Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.


Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).


RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.


Eight plasmaphereses were performed over six weeks.


Volatiles were assayed by gas chromatography-flame-ionization detection.


The clinical and pharmacological histories of these patients suggest a relation between cholinesterase inhibitors and the pleurothotonus.


Abdominal examination and laboratory studies were not clinically remarkable.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects.


Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).


Cutaneous side effects caused by interferon are well known.


Three days after stopping the medication he reverted to normal sinus rhythm.


Comparing baseline CGI with that obtained on the date of last evaluation for each patient, a significant improvement in clinical assessment of severity of illness was obtained for the total group (Wilcoxon signed rank test, p < 0.0001).


The purpose of this case report and review is to enhance anesthesiologists' understanding of this phenomenon so that they may better formulate a logical treatment scheme in such an event.


METHODS: The patient received a stem cell transplant from an unrelated bone marrow donor after which he contracted a serious CMV infection manifested in the lungs and retinae.


A 17-year-old girl with a history of wearing cosmetic contact lenses presented with keratitis.


Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms.


A neuroprotective and neuroregenerative treatment attempt with pyridoxine and pyridostigmine was initiated.


Patients who are treated for short-term palliation may be more safely given doses based on ideal body weight.


Necrotizing fasciitis of the vulva during chemotherapy.


His seizures were controlled by 150mg/day of phenytoin in combination with primidone.


High-dose phosphate treatment leads to hypokalemia in hypophosphatemic osteomalacia.


In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.


We suggest that it may be more appropriate and economical to advise patients to report promptly any suspected side effects than to perform regular LFTs, which may be misleading.


The onset of disease was noted up to 2 months after the last gemcitabine infusion.


This report deals with a 54-year-old man with loss of memory.


Intracranial pathological changes can occur as a result of impaired craniocervical venous return.


Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.


Possible heart failure exacerbation associated with rosiglitazone: case report and literature review.


The diagnosis was confirmed following a single-blind, placebo-controlled provocation test with phenylbutazone and a biopsy of the affected skin.


The immune tolerance in a 12-year-old haemophilia A patient was carried out at the Faculty of Medicine, Ramathibodi Hospital, Bangkok in 1998.


During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.


Hypomagnesaemia in children with cystic fibrosis (CF) is under-recognized.


Role of ciclosporin in steroid-responsive sudden sensorineural hearing loss.


An unusual case of Candida tropicalis sepsis in a patient submitted to allogeneic bone marrow transplantation.


This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.


A review of possible pathogenetic factors is given.


Recurrent endophthalmitis after cataract surgery with a scleral-tunnel incision.


The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.


This adverse reaction is reported for the first time in a patient not concomitantly treated with other drugs associated with the appearance of priapism.


Recurring periods of prolonged erections in patients with sickle cell disease (stutter priapism) are uncommon, yet troubling sequelae of hemoglobinopathies.


We describe two cases of drug-induced myopathy during long-term treatment of chronic hepatitis B with clevudine.


Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.


Such a low incidence suggests a hypersensitivity type of reaction.


A patient with HIV infection was successfully treated for pulmonary tuberculosis, but pulmonary inflammation and lymphadenitis worsened dramatically after subsequent combination antiretroviral therapy.


The renal insufficiency of three patients and the timing of the seizures implicate accumulation of ofloxacin as a contributing factor.


An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.


One patient had wrists drop and weakness of the fingers extensors.


The cases include only those whose sexual behavior on treatment became a concern to the patient's family or a social agency.


Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.


Dasatinib-induced pleural effusions: a lymphatic network disorder?


Noncirrhotic portal hypertension (NCPH) represents a relatively infrequent group of conditions that causes portal hypertension in the absence of cirrhosis.


Computed tomography angiography of her chest revealed multiple bilateral pulmonary emboli with a moderate clot burden, which resulted in her hospitalization.


Neutropenic enterocolitis is a severe and potentially life-threatening complication that may affect patients undergoing chemotherapy for acute leukemia or lymphoma.


This concerns 2 male patients who experienced incontinence while taking venlafaxine.


In our experience it is better than single agent chemotherapy.


BACKGROUND: Tumor lysis syndrome (TLS) is rare in the treatment of solid tumors, but it may occur in myelolymphoproliferative diseases.


Similar phenomenon associated with gemcitabine, the only FDA-approved drug for pancreatic cancer, is rarely reported.


These resistances were mediated by a 105-megadalton R plasmid.


Computed tomography of the head performed immediately after recognition of the symptoms showed a hyperdense middle cerebral artery (MCA) sign.


A case report.


Immunosuppressant as well as antistreptococcal therapy in the form of cyclophosphamide and clindamycin was of help.


These are generally of modest intensity and reversible.


Tardive seizure is a serious adverse reaction of electroconvulsive therapy (ECT).


We report on a young adolescent with benign intracranial hypertension which we attribute to the use of minocycline for acne.


Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.


Total immunoglobulin E and skin prick tests were normal, however.


Although the drug is generally considered safe, there are reports of side effects including psychosis and hepatitis.


A symptom-triggered intensive care unit treatment protocol consisting of a benzodiazepine and antiadrenergic agents was started.


After 15 months of unsuccessful diagnosis and management, the patient was seen at the Orofacial Pain Unit of the Oral Surgery and Implantology master's degree program of the University of Barcelona.


He also achieved a complete response but only after rituximab was added to IVIG, gancyclovir, solumedrol and IFN.


He tolerated both agents together well, with the exception of experiencing chronic constipation.


Subsequent serial electro- and echocardiograms were normal.


The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.


A magnetic resonance imaging (MRI) scan showed a large mass arising from the posterolateral aspect that was 90% extracranial and 10% intracranial on the right side of the skull.


It is also interesting that one of our cases develop RSDS long after transplantation when immunosuppressive treatment was changed.


In the absence of specific limb electrophysiological abnormalities, acute bilateral symmetric phrenic neuropathy was diagnosed.


We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.


PURPOSE: To report a side effect of quinacrine therapy for malaria.


A serum chloroquine concentration at this time (91 micro g/L) was above that considered effective for chloroquine-sensitive P. vivax (>15 micro g/L).


Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.


Adjuvant therapy of bullous pemphigoid with mycophenolate mofetil: old drug, new use.


Is the use of rFVIIa safe and effective in bleeding neonates? A retrospective series of 8 cases.


CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.


We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.


The patient received OLT because of end-stage primary biliary cirrhosis and was found to have de novo HBV infection 3 months later.


The noted increase in the theophylline level after zafirlukast administration is in contrast to the original reports by the manufacturer.


Diagnosis was made based on pathologic findings and detection of typical fungal hyphea in the infected tissues.


This complication has not previously been reported during treatment with sargramostim, a hematopoietic cytokine with activity that overlaps filgrastim.


Serotonin can also cause pruritus when injected into the skin.


Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.


Treatment with interferon-alpha (IFN-alpha), however, led to dramatic clinical, radiographic, and histologic improvement.


After 1 week, HPA axis function was markedly improved.


The panoramic radiograph showed radiopaque material in the inferior alveolar canal region, with an extension from the left canine to the second premolar.


CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.


A search of the literature yielded 15 instances of severe antithyroid-drug-induced granulocytopenia (ATDIA) (granulocyte count of less than 0.1 x 10(9)/L) treated with G-CSF.


METHODS: Growth retardation was observed in six severely asthmatic children after introduction of high-dose fluticasone propionate treatment (dry powder).


Benzoyl peroxide (BP) is commonly used for topical acne treatment and has long been known to be a weak allergen and a strong irritant.


The intramuscular route of administration is associated with cutaneous side effects such as dermal necrosis, sterile abscesses and ulcer formation at the injection site, while urticaria may develop near the site of intravenous drug infusion.


Effective management of the transplant recipient depends on preventing excessive vasoconstriction, usually with calcium channel blocking agents.


Worsening of obstructive sleep apnoeas in a patient with rheumatoid arthritis treated with anti-tumor necrosis factor.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


The authors suggest that risperidone may increase affect in patients with schizophrenia and that some patients, especially those with anxiety, may have difficulty managing the increase.


It would seem that some travelling roots of the sympathetic nerve were preserved from the chemical neurolysis and the remaining efferent and afferent nerve fibers were responsible for the persisting low frequency HAR wave and pain in the left leg.


The clinical picture and efficacy of mirtazapine will be discussed.


This is the second report of lactic acidosis in a patient on stavudine and lamivudine.


We report an unusual case of a leiomyosarcoma of the urinary bladder after chemotherapy for retinoblastoma and the results of a review of the published reports of bladder sarcomas.


CONCLUSIONS: In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.


Veno-occlusive disease (VOD) is a life-threatening complication following allogeneic or autologous stem cell transplantation.


Hypoalbuminemia and thrombocytopenia were observed at this time also.


To the best of our knowledge, this is the first report of 1,25-dihydroxyvitamin D-mediated hypercalcemia caused by PCP in a renal transplant recipient.


On day 7 of radiation therapy, she developed an extensive erythematous maculopapular rash over her face, trunk, and extremities.


CASES REPORT: Three eyes of three patients with mCNV were examined with fluorescein angiography (FA) and ICGA using Heidelberg Retinal Angiograph 2 and the conventional fundus camera before and after IVB.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


When a 34-year-old woman had dyspnea and chylothorax 8 months postpartum, lymphangiomyomatosis was diagnosed by open-lung biopsy.


Glycyrrhizin (GL) at a dose of 400-1600 mg/day (7.2-30.8 mg/kg/day) was administered intravenously for a period of more than a month, on 6 separate occasions, to 3 hemophiliacs with acquired immune deficiency syndrome (AIDS).


These findings were low serum T4 (3.8 micrograms/dl), T3 (23 ng/dl), and a failure of serum TSH to rise after TRH injection.


CASE: A 33-year-old female, gravida 1, para 1, was treated with gonadotropin-releasing hormone agonist (GnRH-a) for three months prior to laparotomy and removal of a solitary, 5,190-g, pedunculated myoma.


Cutaneous fragility induced by hypercorticism is an important cofactor permitting direct inoculation from the environment.


CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.


Furosemide-associated fever.


Adenosine has become the preferred treatment for common types of supraventricular tachycardia because it is extremely effective and rarely associated with with serious side effects.


No adverse effects were noted from either vancomycin or hemodiafiltration.


CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.


Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.


So far, few cases of pulmonary side effects caused by ticlopidine have been reported.


Desensitization was started at 1mg daily, and then the dose was doubled every week.


Furthermore, radial keratoneuritis was demonstrated, consisting of an irregularly swollen nerve fiber with probable amoebic infiltration.


In this case, unlike those previously reported, hyponatremia recurred 5 months after switching from citalopram to mirtazapine, which is believed to be a safe antidepressant.


CASE REPORT: We report the case of a 58 year old patient who, after 2 days of treatment with roxithromycin and betamethasone, manifested acute pancreatitis.


Studies in the father suggest that the aldosterone production by his adrenals is hyperresponsive to adrenocorticotropic hormone (ACTH).


Monitoring of liver enzymes was not performed during the treatment period.


The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.


Optic neuropathy associated with penicillamine therapy in a patient with rheumatoid arthritis.


The remaining two patients were alive and well at median follow-up of 24 months (range, 4-25 months).


He was fed by mouth and had occasional episodes of coughing and choking during feeding.


CONCLUSIONS: All primary eye care clinicians should be aware of this new and unique clinical presentation and be prepared to recognize it quickly and treat it appropriately.


We report the first case of tuberculous uveitis due to etanercept.


All the cases reported so far, including the current case, have involved tumor located in the lumbosacral region.


The mother had systemic lupus erythematosus and cyclophosphamide exposure in the first trimester.


These were gradually lysed after two successive administrations of streptokinase (1.5 x 10(6) units over 24 h), and one session of recombinant tissue type plasminogen inhibitor (100 mg over 6 h).


Risperidone in the treatment of delusions of infestation.


Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy.


When children wheeze Would no one please provide their medicine blindly: for this might ease their young demise and that would be unkindly.


In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.


A skin biopsy examined by light and electron microscopy showed no morphological abnormality in the sweat glands.


After ingesting 500 mg of the drug, she experience generalized maculopapular eruption and facial angioedema.


The patients who were treated with Lp-TAE combined with HT had a tendency to have better survival rates than those of the Lp-TAE group (p less than 0.099).


We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).


CONCLUSIONS: A potential interaction exists between VPA and all ritonavir-boosted antiretroviral regimens.


One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.


The fact that this phenomenon was not seen in >1,400 patients studied in clinical trials indicates that it is likely to be rare and idiosyncratic.


Three had low values of IgA, and all had normal values of IgM, IgD and IgE, and blood cells.


Successful treatment with partial resection of the posterior mitral valve leaflet and antibiotic therapy with cefazolin.


Possible mechanisms of action are discussed.


Alopecia and hair loss are rare side effects of psychotropic drugs.


DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.


The myoclonic symptoms continued until March 18, when they subsided.


Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.


A 25-year-old woman with mild hyperphenylalaninemia developed disabling depression and panic attacks.


Upon discharge from ICU all laboratory tests were normal and blood lead level was reduced, but he was quadriplegic.


Additional PKP was performed with perioperative intravenous administration of ganciclovir.


This case raises concern about the possible adverse consequences of hormonal manipulation in treating infertility.


One of the side-effects of intravitreal triamcinolone is the development of cataract, and it is known that cataract extraction can exacerbate macular degeneration.


Successful treatment of hyperthyroidism with amiodarone in a patient with propylthiouracil-induced acute hepatic failure.


A 74-year-old man who had been diagnosed with malignant mesothelioma developed malignant lymphoma of B-cell origin involving the penis.


Resolution occurred in spite of continuous tocolytic therapy, which was stopped at 35 weeks.


Controlled clinical trials are indicated to determine if this finding is indicative of a class effect for all GABAergic antiepileptic drugs (AEDs), as already noted with vigabatrin, or if this case represents an incidental finding with tiagabine (41 references).


Valvular endocarditis after percutaneous coronary intervention is unusual.


All seven patients recovered without sequelae.


The drug was discontinued, and the fever resolved within 2 days.


CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.


Therefore, these patients might have to be treated with granulocyte colony-stimulating factor to be able to recover from severe neutropenia.


A case report.


We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.


Dapsone in rheumatoid arthritis.


Shortly after chemotherapy and an injection of pegfilgrastim, the patient developed poorly defined, rapidly progressive erythema, edema, and pain in his right forearm.


The use of pamidronate for hypercalcemia secondary to acute vitamin D intoxication.


We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.


PURPOSE: To evaluate the long-term efficacy and side effects of off-label topical tacrolimus 0.03% ointment (Protopic; Fujisawa Health, Deerfield, IL) as a sole second-line immunosuppressive agent in the management of high-risk corneal grafts.


The two patients were successfully treated with pharmacological thrombolysis with no recurrence.


Primary sensory symptoms in parkinsonism.


However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.


Seven patients with congestive heart failure receiving long-term diuretic treatment (more than three years) experienced idionodal tachycardia in the presence of apparently normal serum digoxin levels.


The great majority of patients have no problems with their prescribed hypoglycaemic medication.


Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.


Two cases of hypothyroidism in patients with chronic hepatitis C treated with recombinant alpha interferon are reported.


The causative relationship was proven by challenge.


We report a case of peritonitis in a patient on continuous ambulatory peritoneal dialysis caused by Listeria monocytogenes.


The unusual severity and rapid spread of the infection, despite normal neutrophil count and prompt antifungal therapy, suggest that HIV-related immunocompromise might play a role in the impairment of host defences against Aspergillus infection.


We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.


PTLD systemically was seen in 6% of the liver, 7% of the heart, 5% of the lung, 11% of the heart-lung and 4% of the kidney allografts.


Akathisia is a relatively rare side effect with the newer atypical antipsychotic agents, particularly clozapine, and is easily misdiagnosed in children.


He had miliary tuberculosis, renal failure requiring dialysis and visual disturbances.


CONCLUSION: Our case sheds new light on glucocorticoid pancreatotoxicity and confirms the role of macrolides as potential pancreatotoxic drugs.


We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.


In clinical trials, venlafaxine was found safe and effective in most patients.


Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.


BACKGROUND: The risk/benefit ratio of warfarin therapy changes in the over 75s, when haemorrhagic side-effects become more common.


Definitive therapy by subtotal thyroidectomy was subsequently performed and yielded good results.


We present the 30-month follow-up of a 12-yr-old girl affected by diabetic ketoacidotic coma, complicated by rhinocerebral mucormycosis and successfully treated with POS at the initial daily dose of 5 mg/kg t.i.d. with fatty food for 3 wk, followed by a daily dose of 10 mg/kg in four doses for 2 months and then 20 mg/kg/d in four doses for 16 months and in two doses for further 5 months.


It is a necrotizing inflammation of the cecum, colon, and the terminal part of the ileum.


DISCUSSION: It is not uncommon to confuse drug allergy with JHR.


Further study is needed to determine the incidence of subclinical membranous nephropathy in patients with rheumatoid arthritis, and the effect of drugs in triggering clinical manifestations of this condition.


Here we report on a 10-month-old boy with an anaplastic astrocytoma, who acquired an HHV-6 variant B infection during chemotherapy.


With treatment, the serum CBZ concentration declined, and the EEG became more continuous and rhythmic without epileptiform discharges.


I just thought that was my quality of life on dialysis.


Self-limited edema is a well-recognized complication of insulin therapy.


The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.


It is the first reported case of TMA being cured with treatment of CMV.


We report on a patient with an embryonal teratocarcinoma of the testicle who had the syndrome of inappropriate secretion of antidiuretic hormone after receiving a high dose of vinblastine.


Corticosteroid-induced glaucoma is a well-recognized phenomenon in adults, but not children.


Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.


Examination revealed severe anterior uveitis with fibrinous exudates in the anterior chamber, flap edema and epithelial bullae.


We report two cases of late recurrence of eruptive locoregional metastatic melanoma occurring 6 and 9 years after definitive surgical treatment.


Use of the Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between the patient's development of hepatotoxicity and the TMP-SMX therapy.


The right palm also showed similar changes.


Glycerol and urokinase produced rapid resolution of the symptoms and warfarin prevented further recurrence of pseudotumor cerebri for one year.


METHODS: We performed a retrospective review of ICD procedures performed at a single academic center and identified all ICD-related infections managed between 1983 and 2005.


CASE SUMMARY: A 72-year-old white man was admitted for worsening palpable purpura over a two-day period.


A range of adverse effects have been reported, including neuropsychiatric reactions in patients known to be taking recommended doses.


Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.


Nausea, vomiting and acute pancreatitis were also observed in one patient.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.


Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.


Both the TMA and the CMV resolved after initiation of the ganciclovir.


Intestinal pseudo-obstruction was a prominent feature in the patient in this study.


Severe hypomagnesemia occurred in this patient and published literature is highlighted.


Minimal change disease in a patient receiving IFN-alpha therapy for chronic hepatitis C virus infection.


Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.


Liver transplantation for fulminant hepatitis related to nevirapine therapy.


There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.


This was complicated by a persistent cerebrospinal fluid leak that was successfully managed by purse-string sutures over the dura around the catheter, without removing the intrathecal implant.


Early high-dose intravenous methylprednisolone in acute disseminated encephalomyelitis: a successful recovery.


Protamine allergy as a complication of insulin hypersensitivity: A case report.


Secretory endometrial adenocarcinoma in a patient on tamoxifen for breast cancer: a report of a case.


Further exacerbations of the rheumatic condition may be induced by treatment of the cancer.


Immunoblots conducted with hepatic microsomes from control and induced rats and purified rat P450s confirmed that these antibodies also recognised constitutive (3A2) and inducible (3A1) rat CYP3A products.


Anti-tuberculous drugs, including ethambutol, were initiated at our clinic because the period between the ethambutol therapy and visual loss was too short and the dose of ethambutol was not very high.


Hypercoagulability studies were negative.


Upon presenting to the primary care service a year and a half later, the patient was taking 40 mg per day of olanzapine and had gained 62 pounds, a 30% increase in body weight; glycosylated hemoglobin (A1c) was 11.1%.


Urologists should bear in mind this clinical entity, particularly when DMSO is administered to patients with multiple drug allergies.


An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.


Leuconostoc sp. are gram-positive bacteria intrinsically resistant to vancomycin, which can be confused with streptococci based on routine microbiological-characteristics.


Spontaneous resolution of the thrombus such as is reported in this case is exceptional.


Repetitive paroxysms of supraventricular tachyarrhythmias triggered during pediatric cardiac interventions: suppression after short infusion of amiodarone.


Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.


He presented to the emergency room, was evaluated by the orthopedics service, and taken to the operating room for debridement of suspected necrotizing fasciitis.


To the authors' knowledge, this is the first case report of the successful treatment of disseminated cutaneous phaeohyphomycosis in a dog.


The necessity of placing such grafts behind the ureters is reiterated and the routine performance of preoperative and postoperative excretory urography is suggested.


METHOD: The case histories of three geriatric patients treated with fluoxetine for depression or obsessive compulsive disorder are presented.


We present the case of a 17-year-old male who ruptured his Meckel diverticulum 23 days after the beginning of induction chemotherapy for high-risk acute lymphoblastic leukemia.


We describe a patient who developed disseminated Fusarium infection with a secondary fungal endophthalmitis after an autologous bone marrow transplant for acute myeloid leukemia.


Subsequently, an improvement in the hemodynamic profile (BP 140/78 mm Hg, mean HR 91 beats/min) was noted.


We report the results of three cases of limited-stage SCEC treated with combination therapy using carboplatin (CBDCA) and etoposide (VP-16) and radiotherapy.


Given the current debate about the risks of hormonal replacement therapy, more women are seeking alternative therapies for menopausal symptoms.


This syndrome is potentially life-threatening: the 5 untreated patients died, whereas 5 patients given immunosuppressive therapy are alive.


Within 36 hours after recovery, the mare developed signs of severe pain that were unresponsive to conventional treatment.


Severe oligohydramnios was noted.


The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).


Pre-treatment evaluation for the presence of arterial shunts to neighbouring organs should be determined in order to avoid complications of SIRT.


The authors report a case of a Hickman catheter perforating the wall of the superior vena cava into the pericardium, resulting in accidental intrapericardial infusion of 5-fluorouracil (5-FU).


The urine revealed inappropriately high levels of magnesium and potassium despite critically low serum levels, with an appropriately low urine calcium level.


The patient was treated with octreotide 20 mg, at monthly interval.


Total white cell count and neutrophil count returned to normal and she made an uneventful recovery.


Atypical mycobacterial infections of the musculoskeletal system are very rare and are generally associated with predisposing factors, such as trauma, use of corticosteroids, or an immunocompromised state.


Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.


False-positive proteinuria by acid precipitation testing in tolmetin-treated patients has been noted on routine urinalysis screening.


Eruptive epidermoid cysts resulting from treatment with imiquimod.


The Jarisch-Herxheimer reaction is a response to the treatment of syphilis.


A possible case of carbamazepine induced pancreatitis.


One patient required a second separate stent-graft placement procedure because of migration of the initial device; the second patient underwent surgical repair of a ruptured mycotic abdominal aortic aneurysm followed immediately by stent-graft placement for a chronic mycotic thoracic aneurysm; a third patient underwent repair of two infected false aneurysms secondary to complete rupture of a surgical interposition graft.


MANAGEMENT: Discontinuation of temozolomide, discontinuation of radiotherapy, antibiotic treatment with amoxicillin and gentamicin, and administration of atovaquone and pentamidine.


OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.


The literature review revealed that many cases typically present with chronic cough with or without dyspnea.


This is largely a result of the low levels of compliance.


SKT has several pharmacological effects including analgesic and antiinflammatory effects, vasodilation, and muscle relaxation.


The infection persisted despite more than 8 weeks of treatment with liposomal amphotericin B.


We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.


We describe various measures to reduce severe anxiety that interfered with much-needed maintenance electroconvulsive therapy in a 32-year-old man.


No side effect was seen.


We present a case of a patient with long-standing schizophrenia who was treated with clozapine.


BACKGROUND: Pseudoporphyria is a photosensitive bullous skin disease that is distinguished from porphyria cutanea tarda (PCT) by its normal porphyrin profile.


Treatment of antithyroid drug-induced agranulocytosis by granulocyte colony-stimulating factor: a case of primum non nocere.


Reinstitution of intravenous anticholinergic medication provided relatively prompt relief.


BACKGROUND: Fluoxetine, a highly specific serotonin reuptake inhibitor, has been reported to cause sexual dysfunction in a minority of patients.


CASE PRESENTATION: The patient is a 22-year-old male with the evaluation of osteosarcoma, T1Gr2NxM0.


All of the patients and three of the carers recorded scores suggestive of psychiatric morbidity on the General Health Questionnaire.


Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.


Acute syphilitic posterior placoid chorioretinitis following intravitreal triamcinolone acetonide injection.


Late-onset donor-to-host transmission of Candida glabrata following corneal transplantation.


Intensive organ supportive measures and intravenous antibiotic therapy led to his gradual recovery.


We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.


CONCLUSIONS: The findings are expected with age-related macular degeneration with crystalline drusen, but also with CAR.


A bone marrow aspiration demonstrated an increased number of macrophages with hemophagocytosis.


The exceeding of the solubility product of Ca(2+) and PO(4) (-) results in the precipitation of calcium phosphates.


We describe a case of disseminated muscular cysticercosis followed by myositis (fever, diffuse myalgia, weakness of the lower limbs, and inflammatory reaction around dying cysticerci) induced by praziquantel therapy, an event not described previously.


Within 60 min after start of treatment the effective valve area increased (1.41 cm2), and the pulmonary capillary wedge pressure decreased.


The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.


The goal of this study is to describe three patients diagnosed with migraine and epilepsy (both under control) who evolved into status migrainosus after the introduction of oxcarbazepine (OXC), as part of a switch off from carbamazepine (CBZ).


Although HAART is very important in the treatment of HIV, its side effects are responsible for patients' non-adherence to medications.


DISCUSSION: According to the literature, reversible nonthrombocytopenic palpable purpura has not been previously reported with metoclopramide.


Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine.


Relentless growth and recurrence carry a poor prognosis.


The patient was treated with IFN-alpha in another medical center for 6 months because his liver biopsy showed chronic active hepatitis.


More recent literature suggests that probably all antidepressants can appear in human milk.


Although arachnoiditis, infection, and meningitis have been reported, acute paraplegia has not been reported as a complication of either caudal or spinal epidural steroid injection.


Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.


BACKGROUND: Zidovudine, a Nucleoside Reverse Transcriptase Inhibitor (NRTI) is one of the earliest antiretroviral agents used as a combination in the Highly Active Antiretroviral Therapy (HAART) for the treatment of HIV infection.


Patient-controlled rapid atrial pacing was used to manage 12 cases of recurrent supraventricular tachycardia refractory to drug therapy.


A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.


The response to tetrahydrobiopterin therapy was impressive at an oral dose of 50 mg twice a day.


Hospital admissions at Thomas Jefferson University Hospital between 1982 and 2002 that carried the dual diagnosis of systemic lupus erythematosus and pancreatitis were identified, and demographic data, clinical interventions and parameters of clinical progression of their disease were identified.


During a subsequent course of radiotherapy, the patient developed fever, headaches, and cutaneous lesions.


Tamoxifen inhibits protein kinase C (PKC) in vitro and thus may regulate glioma cell growth by modulating intracellular signal transduction.


Case report.


Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.


A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia.


We describe the clinical and histologic features of this chemical and traumatic alopecia as well as that of frontotemporal chronic traction alopecia resulting from use of sponge rollers.


Unlike Corynebacterium jeikeium, which is highly resistant to beta-lactam agents, aminoglycosides, and quinolones, all strains of C. striatum isolated from the patients described in this report were susceptible to vancomycin and aminoglycosides, and all strains except one were susceptible to penicillin G, imipenem, and ciprofloxacin.


The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.


We review the literature concerning an increasingly reported and interesting adverse effect, atypical antipsychotic-induced obsessive-compulsive symptoms (OCS).


However, physicians must keep in mind the significant risks of using this medication.


On fundoscopy and fluorescein angiography, the first signs of a bilateral bull's eye maculopathy were detected.


We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.


Clinical and electrodiagnostic findings are discussed in detail and a brief review of the literature is presented.


New neurological symptoms developed immediately after injection, and magnetic resonance (MR) imaging demonstrated trapped air displacing the dural sac.


At dosages 22.5-30 mg/day (0.45-0.57 mg/kg/day) longstanding non-convulsive status epilepticus was noted in all three patients.


Theoretically, it may be useful in reversing anticholinergic ileus resulting from acute drug overdose, allowing or enhancing decontamination, but the safety and potential efficacy of neostigmine in this scenario have not been established.


This advantage must be weighed against the risks (immunologic reactions, loss of the therapeutic effect of the cardiac glycoside if an overdose of antibody is given).


Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.


Seizure with hyponatremia in a child prescribed desmopressin for nocturnal enuresis.


Although uncommon, an intact anterior vetreous face against the corneal endothelium is possible when a wide opening has been made in the posterior capsule and the underlying vitreous face remains intact.


In the following months, these lesions increased in number and size and neurologic symptoms developed.


Drug-induced pemphigoid.


In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.


Myocardial infarction in a parturient.


Irritative skin reactions were observed only at higher testings doses, in contrast to the allergic type of reaction, which occurred at a lower testing dose.


The initial in-hospital management of adult patients with community-acquired pneumonia can be divided into five major steps: an early recognition of the patient with presumptive pneumonia, assessment of the severity of illness, establishment of an etiologic diagnosis, supportive therapy, and decision regarding initiation of empirical therapy.


Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.


It may also be prudent to screen for electrolyte abnormalities in patients taking this agent to prevent serious iatrogenic complications.


Pregnancy and neonatal outcome were uneventful in both.


As judged from the clinical course of this major surgery, recombinant FVIIa appears to be highly efficacious and safe and should be used as first line treatment in high titre inhibitor patients with cross-reactivity to porcine factor VIII, undergoing surgery.


Treatment of acromegaly with octreotide, followed by successful selective pituitary adenomectomy, stabilized the number and the size of the liver tumors.


The difficulty in absorbing vitamin B12 when intrinsic factor is not available does not make oral replacement impossible; the dose just needs to be higher.


Although thrombolysis per se can cause severe and potentially fatal haemorrhage, there is no evidence that severe bleeding events occur more often when thrombolysis is combined with cardiocompressions.


He did not respond to treatment with oral iron not a proton pump inhibitor and an upper endoscopy was performed.


Did we learn evidence-based medicine in medical school? Some common medical mythology.


Phenobarbital treatment in a patient with resistant alcohol withdrawal syndrome.


Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.


We present a 60-year-old woman with anal cancer and liver metastasis.


Linear IgA bullous dermatosis (LABD) is an immunobullous disorder in which IgA antibodies are deposited within the basement membrane zone.


Pseudomonas aeruginosa was cultured not only from the corneal ulcer but also from the contact lens solutions, suggesting that the patient had been noncompliant with care procedures.


As a consequence, the use of a broader initial antibiotic coverage, including extended-spectrum cephalosporins and combinations, seems to be more common in North America than in Europe.


The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.


The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.


Postoperatively, the patient developed bilateral lower extremity weakness, which was at first attributed to epidural administration of local anaesthetics.


Progressive outer retinal necrosis after bone marrow transplantation.


We present a report of B. henselae infection transmitted by the same kitten to 4 different individuals, each with different clinical characteristics, treatment, and evolution.


A rapidly progressive, fatal recrudescence of pulmonary Kaposi sarcoma developed in an HIV-infected man who was receiving corticosteroids for treatment of an immune reconstitution syndrome secondary to Mycobacterium avium complex pulmonary infection.


Her medical history was remarkable for long-term opiold dependence associated with the treatment of multi-Joint degenerative osteoarthritis.


CONCLUSION: Celiac disease must be ruled out in patients with malabsorption complaints in or after interferon (or pegylated interferon) therapy.


Diethyl carbamazine citrate, an inhibitor of release of SRS-A, seemed to shorten the duration of the LAR, although it has no effect on the immediate response and/or on the severity of the LAR.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.