The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.


Resolution of protein-losing enteropathy and normalization of mesenteric Doppler flow with sildenafil after Fontan.


The tryptase sera level was 109 mg/L one hour after the reaction had subsided, while the basal values were normal.


The authors describe a patient with hemiparesis who developed the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) while being treated with lithium for a manic episode.


Burn of the auricle.


Liver biopsy showed intralobular inflammatory infiltrates, confluent necrosis and apoptosis, compatible with drug-induced liver disease.


His medical history included ischemic cardiomyopathy, pacemaker placement, ESRD, carotid artery disease, and type 2 diabetes mellitus.


Furthermore, beneficial or harmful effects of steroids in eosinophilic jejunitis and its treatment details are discussed and reviewed.


Cytomegalovirus pneumonia in a patient with breast cancer on chemotherapy: case report and review of the literature.


Large part of these nodules were suspected to be well differentiated hepatocellular carcinoma with high level of serum alpha-fetoprotein (AFP) up to 3,400 ng/ml, but a part of them was evaluated to be a borderline between hepatocellular carcinoma and adenoma with mild cellular atypism.


Various medical treatments had been tried with meager results.


A 66-year-old woman had a sudden onset of small-bowel obstruction during enzymatic treatment for gastric persimmon bezoar.


RESULTS: After a prolonged postoperative course, including administration of topical ofloxacin, tobramycin, chloramphenicol, and dexamethasone, UCVA returned to 20/20.


Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.


A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds, admitted for a manic episode and treated with levomepromazine, diazepam and lithium carbonate.


Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.


Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases.


A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.


Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.


RESULTS: Findings and course were typical for the recently described progressive outer retinal necrosis syndrome.


In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.


Its use, together with other techniques, such as mycologic, cytologic and histological examinations, allowed us to identify Candida albicans as aetiological agent in this particular case.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.


The Jarisch-Herxheimer reaction in ocular syphilis.


Camptocormia occurred concomitantly with an increase of the plasma valproate level from about 330 mumol/l up to 530 mumol/l.


After three weeks of carbamazepine therapy, the patient arrived at the emergency department (ED) with severe agitation and aggressive behavior.


He underwent five sessions of plasmapheresis.


Serum aluminum levels were significantly (P less than 0.001) higher in these 3 infants and in 1 other, all of whom received more than 100 mg of elemental aluminum per kilogram of body weight per day (mean +/- S.D., 371.0 +/- 178.9 ng per milliliter [13.75 +/- 6.6 mumol per liter] ) than they were in 8 older children with azotemia who were not undergoing dialysis and who received less than 100 mg of elemental aluminum per kilogram per day (27.0 +/- 18.6 ng per milliliter [1.0 +/- 0.68 mumol per liter] ), 7 such children who did not receive aluminum hydroxide (20.28 +/- 9.2 ng per milliliter [0.75 +/- 0.34 mumol per liter] ), and 16 children with normal renal function (21.04 +/- 4.9 ng per milliliter [0.78 +/- 0.18 mumol per liter] ).


The first case of keratitis caused by Nocardia exalbida.


With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).


METHODS: We present the clinical findings, pertinent laboratory data, and follow-up course of a patient with Graves' disease and bilateral sensorineural hearing loss.


Precursor prothrombin status in two mother-infant pairs following gestational anticonvulsant therapy.


Serum samples were collected throughout the infectious process for viral DNA analysis.


His electrocardiogram revealed minor abnormalities, including a prolonged QT interval.


This agent has severe teratogenic effects, as serious craniofacial, cardiovascular, thymic and central nervous system malformations.


TSH remained persistently raised and the patient became thyrotoxic.


CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.


The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.


Early detection of these cases has practical importance since the identification and elimination of the causative drug is essential for therapy success.


Treatment of chronic hepatitis C with interferon alpha (IFN-alpha) is relatively contraindicated in patients with psychiatric disorders because of possible severe psychiatric side effects.


Endoscopic management of a new entity-plastobezoar: a case report and review of literature.


Cardiac arrest associated with sulprostone use during caesarean section.


Two patients died.


Dopamine dysregulation syndrome in a patient with restless legs syndrome.


This case may start a debate on the susceptibility of central nervous system tumors following chemotherapy in patients with ITO.


Ultrasonography showed ciliochoroidal effusion.


We report on a 64 year old patient with a severe flare-up of UC who responded well to intravenous CyA after a standard therapy with high dose corticosteroids alone had been ineffective.


The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.


Two female patients presented nodular erythematous lesions overlying a permanent tattooed eyebrow and lip, respectively.


Transoesophageal echocardiography (TEE) was performed which showed a multilobulated liquid-filled mass (3.6 x 3.7 cm), adherent to the septal, anterior and posterolateral LA most consistent with thrombosis.


BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.


OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.


Before retreatment, the best corrected visual acuity (BCVA) ranged from 20/40 to 20/200.


Daily measurements of pulse, blood pressure, temperature and various laboratory examinations were carried out.


A case of bullous pemphigoid in a patient on hemodialysis.


In the early postoperative period, pulmonary thromboembolism was suspected and confirmed by lung perfusion scintigraphy which showed bilateral segmental and subsegmental perfusion defects.


Delirium after cessation of glucocorticoid therapy.


In a patient without evidence of hypersensitivity (the lymphocytes did not react to the drug in vitro) fever was the sole manifestation of an adverse reaction to cimetidine that was confirmed by challenge with the drug.


After a 8-year follow-up since transplantation, the patient is free from dyspnea, angina, and adverse cardiovascular events.


BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.


Other features of this adverse drug reaction were unremitting fever, leukocytosis with eosinophilia and atypical lymphocytosis, and proteinuria.


Post resuscitation there was no myocardial infarction and she had complete neurological recovery.


The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.


Vitamin D toxicity is associated with enhanced resorption of bone in some patients.


Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.


Five hours after arrival, the patient reported a recurrence of severe chest pain.


The authors report a case of acute pancreatitis (AP) occurring in a patient under treatment with carbamazepine (CBZ) for post-traumatic petit mal epilepsy, and review the current literature of drug-induced AP.


The progressive appearance of squamous epitheliomas and other cutaneous adverse events, such as the ulcer, suggests that alternative chemotherapies should be considered for the treatment of myeloproliferative diseases.


Initial plasma concentration of pyrimethamine was 6.22 micrograms/mL.


This case illustrates the diagnostic challenges in the management of such a patient, as well as the need for greater vigilance in the monitoring of liver function tests for patients treated with imatinib.


Finally, the patient had improvement in symptoms and oxygenation after withdrawing lenalidomide and recurrence of symptoms when the drug was restarted.


We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.


A 32 year-old healthy nullipara pregnant woman, with an uneventful past gynaecological history, was admitted in Hospital, with a severe depressive syndrome in a 18 weeks malformed pregnancy for thoraco-omphalopagus conjoined twins.


A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery.


Measurement of serum acyclovir levels substantiated the diagnosis in only a subset of patients.


METHODS: Review of two patients.


Final maintenance dose was 2 mg every 4 weeks in 1 patient, 2 mg weekly in 1, 3 mg weekly in 3, 5 mg monthly in 1, 10 mg every 3 weeks in 2, 10 mg every 4 weeks in 2, 10 mg every 6 weeks in 1, and 5 mg weekly in 2 patients.


We observed 2 cases of hepatotoxicity after a high-dose methylprednisolone treatment of a demyelinating disease and evaluated the potential relationship in the light of available evidence.


Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.


The clinical course and results of renal biopsy studies suggest multiple causes of the renal lesions in this patient.


Herein, we describe 2 patients who developed unusual CD8+ cutaneous lymphoproliferative disorders after treatment with efalizumab and infliximab.


RESULTS: Within the first 4 weeks after the injection, dense cataract developed necessitating cataract surgery.


We report a 67-year-old man with Parkinson's disease for 9 years who developed compulsive use of levodopa.


The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.


The skin lesions healed over the next month.


Drug eruption was diagnosed in a 4-year-old German Shepherd Dog being treated with sulfonamides for vertebral osteomyelitis due to infection with Nocardia spp.


A double-blind challenge with nadolol and captopril decreased FEV1 by 3 and 12%, respectively.


Major surgery for a gastric cancer in a haemophilic with high inhibitor titre successfully performed by the use of recombinant FVIIa.


Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy.


Reversible renal failure associated with angiotensin-converting enzyme inhibitors in polycystic kidney disease.


Antibiotic irrigation of the capsular bag can resolve chronic, low-grade endophthalmitis in culture-positive patients unresponsive to the same drugs administered by other routes, including conventional intraocular injection.


These symptoms abated 1 week after fluvoxamine treatment was discontinued and haloperidol was started.


Severe complications are rarely seen.


Hormonal, ultrasonographic, radioiodine scanning and fine needle aspiration findings were consistent with the diagnosis of Hashimoto's thyroiditis.


PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.


Sarcoma complicating therapy with cyclophosphamide.


Intradermal testing with a wide range of steroid preparations gave positive results to prednisone.


At the time of this writing (2 y), the patient has had no symptoms and has continued on the chemotherapy protocol as planned.


We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome.


The medical and ophthalmic literature was reviewed for current use of these medications as well as for the reported incidence of visual side effects.


We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.


Case report.


De novo inflammatory bowel disease after pediatric orthotopic liver transplant: a case report.


Thrombocytopenia is one of the most frequent challenges faced in patients with chronic liver diseases.


Occurrence in an immunosuppressed patient with chronic active hepatitis.


Tardive dyskinesia in young adults.


Rickets in low birth weight infants receiving total parenteral nutrition.


This finding suggests that eosinophil infiltration may be associated with nasal polyp formation in AIA, and that activation of eosinophils plays an important role in accumulation of eosinophils and polyp formation beginning with the initial stage.


Propafenone-induced ataxia: report of three cases.


One patient suffered coronary artery vasospasm, attributed to the use of topical 1:1000 epinephrine during surgery.


Ten years of behavioral data are presented to support the hypothesis that phenobarbital was exacerbating maladaptive behaviors.


Increased lash length, thickness, and pigmentation are well-documented side effects of prostaglandin analog glaucoma drops.


However, a common source for these infections could not be demonstrated.


Serum and salivary IgA were absent with high IgE serum total.


BACKGROUND: Intracranial malignancies (primary and metastatic) are often complicated by seizure activity.


It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.


This case shows a combined mechanism of DME resolution by anti VEGF and PHD.


METHODS: Prospective interventional case series of three patients with nonischaemic CRVO who were treated with L-CRA.


The case emphasises that immune reconstitution can be an extremely aggressive complication of HAART.


Seven cases of successfully treated Candida albicans cerebrospinal fluid shunt infections are reported.


Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).


Two days later, on hospital day 27, the patient spontaneously delivered two healthy, male infants.


Poor bone vascularisation and reduced local defences prolong the defensive response.


This lead to the hypothesis of a partially dialysable toxic metabolite of muzolimine.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


CONCLUSIONS: Topical brimonidine may be associated with central nervous system depression in infants.


RESULTS: A two-year-old boy was surgically treated for residual esotropia after two botulinum toxin A injections.


These observations suggest that CPH82 has glucocorticoid receptor agonistic effects.


Graft versus host disease after orthotopic liver transplantation documented by analysis of short tandem repeat polymorphisms.


Such a clinical association has not been previously described in the literature and might be due to the persistent expression of gp91phox at a very low level.


RESULTS: Both cases presented here describe corneal ulcers that persisted and showed signs of worsening during weeks of frequent topical dosing with moxifloxacin.


Aortic perforation complicating carcinoma of the oesophagus is extremely uncommon.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


The patient had no history of trauma, lymphatic obstruction, venous obstruction or infection.


Two days after completing this regimen, the patient developed a rash with blistering.


Baseline and follow-up examinations should include: Snellen acuity, Farnsworth D-15 color testing, automated threshold perimetry and optic nerve head photography.


Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.


One was infected by PVB19-contaminated blood transfusion, whereas the other had become infected naturally.


Three patients with niacin-induced visual symptoms had cystoid maculopathy without leakage on fluorescein angiography, and a fourth patient with no fundus abnormality experienced cessation of visual symptoms upon discontinuation of niacin.


Majocchi's granuloma is a condition with chronic erythematous and indurated plaques that is a result of the rupture of a dermatophyte-infected infundibulum as a result of trauma.


A review of the relevant literature follows the case reports.


Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).


The effective valve area was 0.41 cm2.


CONCLUSIONS: Caution should be exercised when using ciprofloxacin in the treatment of patients with personality abnormalities or symptoms of psychosis.


Because the AKBR changes in relation to electron transport in liver mitochondria, it seems to be a logical parameter for evaluating the effect of potassium cyanide poisoning on electron transport.


This case report describes a patient who ingested magnesium sulfate (MgSO4) for approximately four days as a treatment for pregnancy-induced hypertension.


The treatment approach is described and the literature on the subject is reviewed.


The resulting pneumonitis may be severe and irreversible.


To our knowledge, we describe the first reported case of isolated paresthesia and peripheral neuropathy, without systemic involvement, secondary to sulindac administration.


Early recognition of renal toxicity of high-dose methotrexate therapy: a case report.


Brain metastasis was detected in one patient at 7 months after initial therapy and was treated with stereotactic radiotherapy combined with whole brain irradiation.


Cell culture was performed on samples collected from a corneal scraping, the contact lenses and the storage cases.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.


METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.


Here, a rare case of a patient with Type I GD who developed adenocarcinoma of the lung that was treated with chemotherapy, radiotherapy and biological agents inhibiting receptor tyrosine kinases is presented.


Overall, they are the single largest cost to the healthcare system.


Serological studies were carried out using flow cytometry (FCM).


ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.


Although opiates can provide patients with relief from pain and the discomfort of cough, the routine prescription of these drugs for infants demands caution and concern.


The ratio of M-23 to M-1 in her serum was much lower than that of control persons (0.64 vs. 2.08).


Affected persons usually are on chronic steroid treatment and in the fifth to seventh decades of life.


The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.


Histological analysis of a lung biopsy showed a diffuse infiltration with pigmented macrophages without granulomas, which particularly involved the pulmonary arterial and venular walls.


BACKGROUND: Cyanamide, an aversive agent widely used in Japan, is known to induce various degrees of hepatic lesion with ground-glass inclusion bodies.


In a dose titration study we tested the efficacy and tolerance of recombinant human erythropoietin (rhEPO) in 10 patients with myelodysplasia (MDS) and 2 patients with idiopathic myelofibrosis.


Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.


To our knowledge, our report is one of the first on shock and angio-oedema from irbesartan.


Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias.


Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.


A case is described in which non-convulsive status epilepticus (NCSE) prompted further investigation leading to the diagnosis of Lafora body disease (LBD).


It has also been seen in people with gastrointestinal diseases with malabsorption.


No life-threatening situations occurred and the patient fully recovered.


This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.


Other measures including attention to factors that contribute to falls should also be considered, necessitating a multi-disciplinary approach.


Physicians should be aware of the possible association between the use of alteplase and the development of subfascial hemorrhage.


He developed necrotizing pancreatitis, possibly due to regurgitation of the chemotherapeutic agents to the pancreas.


Disseminated Trichosporon infection.


Epsilon-aminocaproic acid and renal complications: case report and review of the literature.


Homozygous loss of TSC1 was identified in one PEComa.


In vitro studies using 3H-thymidine uptake and dual parameter flow-cytometric analysis of DNA and proliferating cell nuclear antigen showed that leukemic blast cells in S phase were increased after incubation with G-CSF.


The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months.


A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.


Although trimethoprim-sulfamethoxazol (TMP/SMX) prophylaxis has been shown to prevent almost all P. carinii infections, 1%-2% of patients may still experience this complication.


Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.


The generalized dystonia improved in the following 3 months and 3 years respectively in 2 patients.


Disseminated histoplasmosis has not been described previously as a complication of bone marrow transplantation.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


Normal endometrial cells in the Pap smear test were the only signs associated with this cancer.


Elimination rates for Staphylococcus aureus and Haemophilus influenzae were similar; adverse reactions did not differ in both arms.


Neither patient has developed evidence of hepatotoxicity.


The patient's condition improved after halothane was administered; treatment with this inhalational anaesthetic lasted 7 h, and the beneficial effect was obtained by employing concentrations between 0.5 and 2%.


The role of antiemetics is invaluable in allowing cancer patients to complete otherwise potentially intolerable chemotherapy.


Two illustrative cases are reported.


There may be a synergistic effect when corticosteroids are used in combination with chemotherapy and radiation treatment.


We conclude that low-dose HU therapy in patients with thalassemia intermedia may increase total Hb levels sufficiently to eliminate the need for transfusions.


The objective of this study was to retrospectively evaluate the clinical outcome of newborns treated with recombinant activated factor VII for intractable bleeding or severe coagulation disturbances, resistant to conventional hemostatic therapy.


Polyacrylamide gel may have favorable properties for facial tissue augmentation, but a severe granulomatous inflammatory response induced by injection of polyacrylamide gel may occur.


Relevant reports to the national Pharmacovigilance Centre were also examined.


Follicular cell carcinoma (FCC) of the thyroid is rarely found during childhood.


Postoperative assessment of intraocular pressure is essential in patients presenting with flap inflammation.


In this paper we report a case of nimodipine overdosage resulting in prolonged hypotension and hypoxemia, which was successfully treated with calcium gluconate.


Lacosamide intoxication in attempted suicide.


Chronic vulval ulceration--another immune reconstitution inflammatory syndrome?


The other 2 eyes experienced regression of the myopia and astigmatism and had a BCVA of 20/25(-1) or better.


INVESTIGATIONS: Blood tests, peripheral blood smear, bone-marrow biopsy and aspirate, Holter electrocardiogram.


During this same time period, 537 patients were admitted with MI, 41 of whom died; the study's 4 patients were compared with these 41.


Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.


DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.


An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.


Development of malignant breast microcalcifications after neoadjuvant chemotherapy in advanced breast cancer.


With either discontinuation or decreased dosage of the drug the symptoms disappeared and did not recur.


The safety of concurrent use has also to be balanced when lithium treatment is started within an ECT course.


The patient had MRSA sepsis develop resistant to conventional therapy, which was successfully treated with daptomycin.


We present a case report of endodontic overfilling involving the mandibular canal.


With rapid recognition and treatment of the syndrome, the patient fully recovered.


Familial Mediterranean fever at the millennium.


The vacuum-assisted wound closure technique and device (the V.A.C.) has become a widely accepted technique in the management of chronic and difficult wounds.


Our present study demonstrates the utility of monitoring auditory function at frequencies higher than conventionally tested in patients receiving cis-platinum.


One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.


Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.


A rare case of lumbosacral meningioma: nondural attachment and possible enlargement by orally administered sex steroid.


Case examples illustrate problems of teacher compliance in filling out measures, supplying adequate placebos, and obtaining physician cooperation, and with the practical issue of providing adequate data without overwhelming the time and resources of participants.


His current medication regimen was hydroxyurea (500 mg BID), iron (525 mg QD), and folic acid (15 mg QD) for the myeloproliferative disease and the associated anemia; spironolactone (25 mg BID) and furosemide (20 mg BID) for the complications of cirrhosis; allopurinol (100 mg QD) to treat gout; and theophylline (250 mg QD) for chronic bronchitis.


The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.


A trial of dexamethasone therapy normalized blood pressure, and plasma and urinary aldosterone decreased to low levels and renin levels increased.


The occurrence of treatment-related hematologic malignancies after adjuvant therapy with alkylating agents for gastrointestinal cancers, ovarian carcinoma, and breast cancer and after treatment for Hodgkin's disease, non-Hodgkin's lymphoma, germ-cell tumors, and multiple myeloma has been well documented.


A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.


Early detection of ototoxicity is of vital importance in cases in which ototoxic drugs are administered.


Laboratory investigations confirmed a metabolic acidosis (pH 7.15) and hyperchloremia.


SCE analysis may provide a method for detecting patients at risk from oncogenic effects of cytotoxic drugs.


OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.


A 21-year-old woman with pars planitis was treated with a subtenon's depot corticosteroid injection that was complicated by the appearance of the corticosteroid suspension within the choroidal vasculature.


The signs and symptoms of intracranial pathology in patients with dural puncture headache, in addition to their postural headache, are discussed.


The second case occurred in a patient who developed renal failure while on daily therapy in the hospital.


In none of these reports has radiologic or pathologic data been presented.


These side effects may be inadvertently confused with other behavioral or psychiatric conditions, especially if exacerbation of existing challenging behavior occurs.


Percutaneous endoscopic gastrostomy is a safe and easy method and carries a low mortality and complication rate.


Ganciclovir-resistant cytomegalovirus (CMV) infection is an emerging problem in transplant recipients.


Neurologic examination revealed right foot drop in Patient A and was unremarkable in Patient B.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Milnacipran was administered at 50 to 150 mg/day, and the dose at 12 weeks or at the time the drug was stopped was 85.0 +/- 31.3 mg/day.


RESULTS: For this patient, clopidogrel (Plavix) therapy was the only risk factor related to SSEH.


Vincristine (VCR) is commonly included in combinational chemotherapy regimens because of its synergy with a variety of other active agents, as well as its sparing of the hematopoietic system.


Sensation of all modalities was intact.


Seventeen had deposits of plasma proteins at the dermoepidermal junction, 16 had deposits in the vessel walls, and one had autofluorescence of the nuclei in the epidermis and vessel walls.


Platelet count was within normal limits on admission and the patient developed no serious consequences because of the purpura.


We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).


Recombinant growth factors appear not to help in shortening the neutropenic period.


E. coli was isolated from urine, blood cultures and later from bone biopsy.


The administration of amyl nitrite and sodium thiosulfate led to a rapid improvement: the parameters reflecting oxygen metabolism improved and the plasma level of cyanide decreased.


Here we present the case of a woman who received high doses of methylprednisolone (1 g iv daily) for active Graves' ophthalmopathy, and developed severe hypertension followed by myocardial infarction on the fifth day of treatment.


Despite a preferential action on cerebral vessels, there is clinical and experimental evidence of effects on systemic vascular and intestinal smooth muscle cells.


Prompt treatment with intravenous antibiotics usually leads to full recovery.


New serologic tests show promise.


Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.


We report a case of acute popliteal artery occlusion after arthroscopic posterior cruciate ligament reconstruction.


Lower extremity arterial insufficiency after long-term methysergide maleate therapy.


Giant cell lichenoid dermatitis in a patient with baboon syndrome.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


A chorio-retinal shunt was demonstrated.


The patient was treated with triple tuberculostatic drug therapy, followed by two-drug therapy, while receiving maintenance chemotherapy for AML, including thioguanine and cytarabine.


CT scan revealed infarction in the territory of the right middle cerebral artery.


METHOD: We identified 101 patients at Yanbian Socio-Mental Hospital and Yanbian Brain Hospital in China who had received clozapine as a primary antipsychotic drug since their first episode of illness and evaluated the prevalence rate, type, and severity of TD using the Extrapyramidal Symptoms Rating Scale (ESRS).


Specimens were evaluated by light and electron microscopy.


Itraconazole withdrawal was followed by rapid improvement, with neurologic examination returning to normal within 6 weeks.


Common hair care practices are a frequent cause of alopecia in black women.


A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy.


An aggressive dose escalation (0.15, 0.2, 0.25 mg/kg/hr for 6 hrs) was done over the next 5 days in an attempt to avoid open-heart surgery.


RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.


The premature infant liver may be deficient in its ability to carry out this step of metabolism, and in normal intrauterine existence the fetus may receive 1,25-DHCC, the active metabolite, from the mother.


To our knowledge, this report describes the first cases of C. striatum causing infection of exist sites of central venous catheters, thrombophlebitis associated with central venous catheters, conjunctivitis, and chorioamnionitis as well as a possible pathogen contributing to peritonitis and pyogenic granuloma.


Our review of 194 RA patients and 38 PsA patients receiving MTX has identified four RA patients and one PsA patient with MTX-induced pneumonitis, giving a prevalence of 2.1% and 0.03%, respectively.


The successful development and implementation of this protocol will have impact on patients who have anaphylactic reactions to MTX but require this medication for specific diseases.


We report two patients with acne vulgaris with a fourth type of minocycline-induced cutaneous pigmentation.


Spinal meningiomas predominantly arise in the fourth to sixth decades of life and are more common in women.


After 2 weeks, visual acuity was better and improvement was evident on topography, pachymetry, and slitlamp photography.


The pupil dilated more widely following this procedure, resulting in an improvement in the patient's visual field.


BACKGROUND: Although 5-aminosalicylic acid (5-ASA) preparations used to treat inflammatory bowel disease are reported to have fewer side effects than sulphasalazine, increased clinical use of these compounds has resulted in increased reports of significant side effects.


Cholestyramine enabled the use of very low doses of sc vitamin K1 (2 mg total) with subsequent attainment of a therapeutic International Normalized Ratio in 39 h.


During chemotherapy suggested pathogenetic factors were monitored without observing any significant abnormality.


Magnetic resonance imaging and angiography showed right internal carotid artery stenosis with ulceration.


Therapy-related myelodysplastic syndrome (t-MDS) was suspected approximately 2 years later; in addition, complex karyotypic abnormalities including 5q deletion, monosomy 7, and der(17)t(12;17)(q13;p13) were found repeatedly in the patient's chromosome studies.


We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.


She subsequently developed microbial keratitis at 1 o'clock adjacent to the limbus.


In December 1983, symptoms of Parkinson disease developed in a 55-year-old man with no history of pulmonary disease, smoking, or asbestos exposure.


METHODS: Retrospective chart review was performed.


CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.


Biopsies revealed an interface dermatitis with epidermal dysmaturation.


The level of ferritin in serum was elevated to 1192 ng/mL.


Eight patients had elevated alkaline phosphatase, 4 elevated IgG and one elevated IgA.


Acetylcholine receptor and anti-skeletal muscle antibody titers were positive in both patients.


Another aqueous humor sample was taken and sent for microscopic examination of sputum for acid-fast bacilli and culture, both of which were positive for MT.


Pamidronate therapy should be considered in patients with hypercalcemia secondary to acute vitamin D poisoning.


Rapid manifestation of cervical vertebral osteomyelitis.


We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).


Inappropriate antidiuretic hormone secretion after high dose vinblastine.


Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism.


We present and exemplify our routine test protocol for monitoring drug introduction and treatment regimen of cholinergic drugs in LEMS.


The total amount received was 27 gm.


We report an HIV-infected woman who developed mild leukopenia as the first sign of a nevirapine-related adverse event, which was followed by skin and hepatic toxicity associated with a more severe leukopenia.


CONTEXT: Acute drug induced hepatitis has not been commonly associated with epidermal growth factor receptor (EGFR) inhibitors.


In-vitro rechallenge of the patient's lymphocytes with cytochrome P-450 generated metabolites of phenobarbital showed extensive cytotoxicity compared to control.


His recovery was uneventful.


Presence of hypertriglyceridemia, very high serum levels of ferritin and hemophagocytosis in a bone-marrow aspirate gave the diagnosis of HLH.


After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.


The pharmacist counseled the patient on the potential hazards of using herbal products with prescription medications.


Spironolactone was continued, as serum creatinine and potassium levels were initially normal.


Further research should be done to define the role of combination antidepressant therapy in the treatment of primary care patients with depression.


DISCUSSION: Haloperidol is often used in the ICU for control of severe agitation, even in patients without a psychiatric history.


She purchased cosmetic contact lenses via the Internet, and followed a contact lens care system irregularly, occasionally using tap water.


A case report.


CONCLUSIONS: Adrenal insufficiency should be suspected in all dialysis patients presenting with fever and atypical symptoms, but only after other potential causes are eliminated; since steroid administration may normalize fever regardless of the etiology, it may mask the signs and symptoms and delay the treatment of other (if any) underlying disorder(s).


Intradermal tests with carboplatin were positive in all three patients and negative with cisplatin.


Treatment is supportive; phenobarbital and carbamazepine may be used with caution as alternate anticonvulsant therapy.


The patient treated with DBS developed severe dyskinesia a few days after discharge and began self medication with amantadine but showed no improvement.


As patients survive longer, long-term therapy-related complications take on greater importance.


Severe overdosage with the antiepileptic drug oxcarbazepine.


Anxiety disorders are currently one of the most common health concerns in the United States.


Drug discontinuation was followed by a complete resolution of the skin eruption.


Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.


CONCLUSIONS: Platinum-based therapies are vital to the treatment of primary peritoneal and ovarian carcinoma.


Enterovirus was detected by the polymerase chain reaction (PCR) in two samples of pleural fluid that were obtained 21 days apart while he was alive.


Most patients can be successfully managed when patient and physician expectations are realistic and aligned, the selection of preventive medications is individualised, and the initiation and titration strategy is appropriate and carefully followed.


The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.


We also found a severe decrease in her serum total carnitine level of 22 micromol/l (normal range 45-91 micromol/l) before changing the diet, suggesting secondary carnitine deficiency.


Despite this experience, the patient continued to deny that quinine was the cause of his problem and that he had failed in his obligations to advise the dentist of his drug history.


We present a case of methanol poisoning in a child in whom the use of fomepizole averted intravenous ethanol infusion and the attendant side effects of this therapy.


Obstructive prosthetic atrioventricular valve thrombosis in a woman with congenitally corrected transposition of the great arteries during estrogen replacement therapy for pituitary dysfunction.


CONCLUSIONS: Topical INF alpha 2-beta is a valid choice for the treatment of CIN in patients for whom surgery is not possible.


CONCLUSIONS: Terbutaline therapy did not appear to be associated with any significant adverse effects and warrants further application and study in this setting.


He became febrile and developed a productive cough and pulmonary infiltrates on postoperative day 4.


Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.


Second cancers including various types of hematological malignancy have been reported in patients with hairy cell leukemia treated with chemotherapy or interferon alfa.


DISCUSSION: Opioid dependence is generally considered synonymous with heroin dependence or dependence on prescribed opioid analgesics.


Results of this study show milnacipran to be beneficial in patients with chronic pain.


A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.


Adjuvant chemotherapy was not indicated and anastrozole hormonotherapy was started.


Diagnosis of invasive aspergillosis of the gut was based on abdominal pain, galactomannan antigenemia and isolation of Aspergillus fumigatus from the stool and was later confirmed by pathohistologic examination.


BACKGROUND: Large cerebral infarction is a rare complication of neurocysticercosis.


Two cases of long lasting bacteremia due to Mycobacterium avium complex despite new macrolides-containing regimens in patients with acquired immunodeficiency syndrome.


Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C.


This may be particularly useful in patients unable to tolerate an alternative class of antihypertensive agents.


METHODS: Diagnostic aids included routine histology and direct immunofluorescence studies to rule out immunobullous diseases and to confirm the c-GVHD.


Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.


All patients were treated with ICD system explantation and antifungal therapy.


Two patients were treated with bretylium tosylate for malignant ventricular arrhythmias after inadequate response to conventional agents.


For one patient, the half-saturation constant was elevated 0.7 log units, suggesting reduction of retinal sensitivity, perhaps from decrease in retinal photopigment concentration.


Ego-alien, suicidal ideas are an extremely rare form of adverse drug reaction.


She also had been treated with oral conjugated equine estrogen (Premarin) because of congenital pituitary dysfunction.


Bisphosphonate induced osteochemonecrosis of the jaw mimicking a tumour.


Continuous EEG monitoring in a patient with massive carbamazepine overdose.


A retrospective review of 4405 patients' charts identified 214 patients who initiated antimalarial therapy between January 1987 and April 1993 for different rheumatic disorders (mean duration of therapy of 17 months).


This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.


Human immunodeficiency virus (HIV) protease inhibitors are associated with several metabolic abnormalities including hypercholesterolemia and hypertriglyceridemia.


Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.


BACKGROUND: Serotonin syndrome (SS) and neuroleptic malignant syndrome (NMS) are medical emergencies associated with psychotropic administration.


Gastro-intestinal side-effects, however, have not been reported in clinical studies dealing with treatment of vasospasm following subarachnoid haemorrhage.


Computed brain tomography was normal.


A patient with chronic myelomonocytic leukemia developed drug-induced pulmonary toxicity after using low dose oral etoposide.


Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.


Energy-dispersive X-ray microanalysis showed the presence of several metals not seen in normal bone.


During surgery the left internal jugular vein was found to be thrombosed and, therefore, ligated and resected.


Dramatic clinical improvement followed prednisone therapy.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


The patient tolerated amoxicillin and cefazolin, suggesting that the sensitizing portion was not the beta-lactam ring.


A 32-year-old woman with lazy bladder was treated with cisapride (10 mg q.i.d.) for three weeks, obtaining a progressive improvement of the symptomatology and urodynamic parameters, and the return to pretreatment conditions after drug withdrawal.


Recombinant human granulocyte colony-stimulating factor in combination with continuous infusion of cytosine arabinoside for the treatment of refractory acute myelogenous leukemia.


BACKGROUND: Superficial basal cell carcinoma can be successfully managed by means other than surgical excision.


Later, confirmatory urine testing of both patients using high-performance liquid chromatography was negative for tricyclic antidepressants.


Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.


Patients with cancer are especially vulnerable to the development of hyper- and hypocalcemia.


A 7-year-old boy with asthma was receiving the leukotriene receptor antagonist pranlukast (Ultair; SmithKline Beecham; Pittsburgh) as part of an open-label clinical trial.


CONCLUSIONS: The need for prophylactic anticonvulsant therapy especially utilizing phenytoin in patients undergoing cranial radiation therapy should be assessed on a case by case basis.


Another patient had a brief relapse two years after the first episode, after a single therapeutic dose of another clioquinol preparation.


Her course, history and outcome are presented and the pharmacokinetics, the mechanism of action, signs and symptoms and treatment of strychnine poisoning are reviewed.


However, the left ventricular ejection fraction was severely decreased (26%), and new regional wall motion abnormalities typical of broken heart syndrome were noted.


We observed an unexpectedly rapid rise in platelet counts with complete haematological recovery after a BEAM regimen, in a patient who could not be rescued by autologous transplant but who received filgrastim, epoetin alfa, and ancestim.


On postburn day 31, he developed a temperature of 108.4 degrees F (42.4 degrees C).


Preventive medications reduce migraine frequency and severity, and improve migraine-specific quality of life.


CONCLUSION: This case identifies another potential etiological factor in the development of TMA after renal transplantation.


CONCLUSION: Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration.


When patients are prescribed tolterodine and warfarin concurrently, clinicians should monitor INR carefully, and a reduction in warfarin dosage may be required.


The cumulative severity of thrombocytopenia observed over successive cycles was accompanied by an increasing TPO response which tended to grow overproportionally in relation to the degree of peripheral thrombocytopenia.


CONCLUSIONS: Our analysis of the published case reports suggests a causal association between green tea and liver damage.


Though proteinuria and nephrotic syndrome is a rare adverse effect of IFN-beta-1b therapy, physicians treating MS patients with this agent should pay careful attention to new clinical symptoms and laboratory findings.


The AUC was between 0 and 6 X 10 ng X min/ml, and AUC normalized to 1 mg/m2 of 6MP was between 0 and 815 ng X min/ml.


BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.


Does acyclovir increase serum lithium levels?


CONCLUSION: Our case shows a fatal side effect of erlotinib.


Tumor necrosis factor alpha (TNF-alpha) inhibitors, such as infliximab, decrease the body's inflammatory response and thus the body's reaction to infection.


BACKGROUND: Bacterial contamination of platelet (PLT) components is an important cause of transfusion reactions.


She underwent a general ophthalmological investigation, perimetry and electroretinographic examination with multifocal (m-ERG) and flash-electroretinogram (flash-ERG).


Adenomyosis in the broad ligament and tamoxifen: report of a case.


We propose that, in addition to hyperperfusion, captopril alters renal function by an additional intrarenal hemodynamic effect.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


Agranulocytosis resolved 4 days following withdrawal of teicoplanin.


This case illustrates the broad clinical spectrum of angioimmunoblastic lymphadenopathy with dysproteinemia and suggests that aggressive treatment is necessary in selected patients.


Simultaneously, systemic dexamethasone and calcium folinic acid were given.


CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.


Suspected inappropriate secretion of antidiuretic hormone in a male with mental retardation.


We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.


Quetiapine (Seroquel) is an atypical antipsychotic drug belonging to a new chemical class, the benzothiazepine derivatives.


The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.


She received 3.8 mg cumulative dose of vincristin before development of ptosis.


BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.


The patient is currently under treatment with prednisone 20 mg/day for systemic lupus erythematosus and with oral mesalazine 2.4 mg/day for Crohn's disease.


Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.


PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.


We indicate that initial and early treatment of the patients with DM and PnM with CsA enabled rapid tapering of the dose of glucocorticoid and improved the disease.


Successful use of Shakuyaku-kanzo-to, a traditional herbal medicine, for intractable symptoms of thoracic outlet syndrome: a case report.


A small dose of protamine sulphate was then administered, which promptly restored hemostasis.


Nocardia exalbida brain abscess in a patient with follicular lymphoma.


The patient was advised to stop administration of the mineral oil and was treated empirically with antibiotics during a 3-month period.


One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.


In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.


He was later skin tested to confirm allergy to MTX.


Baclofen withdrawal: a cause of prolonged fever in the intensive care unit.


The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.


RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity.


Recently, a controversy has arisen as to whether air or saline should be recommended for the correct localization of the epidural space with the loss of resistance technique.


This is a rare complication of bypass surgery and may be a cause of recurrent angina postoperatively due to coronary artery steal.


In all except two patients, serum Na+ returned to normal values within 3 to 12 months of continued lorcainide therapy.


The symptomatology of 18 other paediatric cases of naphthylimidazoline exposure reported to the Belgian National Poison Centre, is also discussed.


The lesions were morphologically distinct and differed in their anatomical distribution during each episode.


Use of perospirone for obesity and diabetes mellitus in patients with schizophrenia: three case reports.


Both experts would obtain an audiogram after the acute problems are treated.


Livedo reticularis associated with interferon alpha therapy in two melanoma patients.


A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.


Ayurveda is an East Indian tradition involving the treatment of medical ailments through the use of herbal medications.


We investigated the patient's serum for all frequent polymorphisms in cytochrome P450 2D6, assuming him to be a poor neuroleptic metabolizer.


He had complex partial seizures refractory to several antiepileptic drugs since 4 years of age.


The addition of certain substrates such as glutamine, arginine and omega-3 fatty acids may improve the body's immune response as well.


Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis.


These findings are significant not only in monitoring amiodarone effects during chronic prophylactic drug therapy but also in providing further insight into the complex interrelation between the action of the drug and the thyroid hormones on cardiac muscle.


Persistent loss of tyrosine hydroxylase immunoreactivity in the substantia nigra after neuroleptic withdrawal.


However, medications containing PPA still can be found in many homes of those unaware of the voluntary recall.


Neither veno-occlusive disease nor thrombotic microangiopathy was documented.


The current study investigated the visual fields and visual electrophysiology of eight patients with known vigabatrin-attributed visual field loss, three of whom were reported previously.


For both the second and third patients, symptomatology failed to resolve until the intraperitoneal cisplatin solution was withdrawn.


Patient responded dramatically to Stellate ganglion block and returned to work within two weeks time.


Thus, the possible in vivo effects of insulin on adipocytes were clearly observed in this case of insulin-induced lipohypertrophy.


Clinicians should be aware that an erythematous and exfoliative rash may be induced by temozolomide, and be familiar with the pharmacologic and supportive measures necessary for its treatment.


We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.


Benign pneumatosis intestinalis in a child with cavopulmonary shunt and immune thrombocytopenic purpura.


Disseminated varicella infection in a child receiving short-term steroids for asthma.


After prolonged recovery periods, only mild neurological deficits persisted in both patients.


The mainstay of therapy has been potassium replacement, however, recent evidence suggests propranolol is a more effective therapy.


As expected, we identified few successful cases of switches from clozapine in our search of the literature.


We suggest, however, that the case against the drugs alone has yet to be proved.


There was a prompt response to the ritodrine hydrochloride.


INTERPRETATION: When high doses of fluticasone propionate are used, growth may be retarded and adrenal suppression may occur.


Other reports are needed to establish whether such placental findings are common lesions after such therapy and to determine their impact on pregnancy outcome.


The depressive symptoms were evaluated using the Hamilton Rating Scale for Depression.


The authors report a woman who took a massive overdose (OD) of carbamazepine (CBZ).


Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.


Overall gains and no change in bodyweight were observed in 83% of patients.


An uncommon cause of delayed postpartum hemorrhage is a pseudoaneurysm of the uterine artery.


Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy.


Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.


CLINICAL FINDINGS: Following recovery from colic surgery to treat compression of the small and large intestines because of a large fetus, the mare was noticed to have signs of femoral neuropathy involving the left hind limb.


Blebitis, early endophthalmitis, and late endophthalmitis after glaucoma-filtering surgery.


Diagnosis by PCR-REA.


Disseminated intravascular coagulation in pregnancy.


Plasma exchange should be done only in an intensive care setting and as a research procedure for children with JRA.


We report here a case of thymic hyperplasia after chemotherapy for acute myeloid leukemia.


Follow-up ECG showed improvement in ST-segment elevation and eventual resolution to pre-event tracing; cardiac enzymes showed slight elevations.


A case of heatstroke is reported in a 32-year-old man diagnosed with schizophrenia and on clozapine monotherapy.


Methylphenidate hydrochloride (Ritalin) is the drug of choice for attention deficit hyperactivity disorder (ADHD).


Methemoglobinemia is a rare cause of cyanosis in pediatric patients.


A pale ginger cat was treated with clofazimine for feline leprosy.


Ten days after withdrawal of Pentasa, he was admitted to hospital because of worsening symptoms.


Reduction in the number of cataplectic episodes per week after 20 weeks of treatment constituted the basis for efficacy determination.


In 20 healthy volunteers we found no slow acetylator genotypes.


L-asparaginase was given subcutaneously on alternate days for four weeks and was well tolerated.


Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.


Complications were minimal and included minor urticarial reactions and intermittent fever.


In the interim, the patient had been transitioned to warfarin.


We report a 12 1/2-year-old girl with acute lymphoblastic leukemia, who developed rapidly growing FCC of the thyroid, 3 years after bone marrow transplantation.


Primary Hodgkin's disease limited to the CNS is exceedingly rare.


The case history and toxicological findings of an infant fatality involving pseudoephedrine, brompheniramine, and dextromethorphan are presented.


The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


On admission, serum calcium and albumin was 3.5 mg/dl and 3.7 g/dl respectively.


Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.


We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.


Ticlopidine-induced interstitial pulmonary disease: a case report.


These results show that i.c. streptokinase rapidly opens an acute coronary artery occlusion complicating PTCA, preventing myocardial infarction.


Measures to minimize transfusion related malaria are discussed.


Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.


Taxane-induced glaucoma.


After a second course of hemodialysis the next day the patient's mental status improved, and she was discharged 5 d later.


Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).


Results of his mycologic examination and cultures came back negative.


Tardive oculogyric crisis during treatment with clozapine: report of three cases.


Improvement and deterioration in systolic function on echocardiogram and serum B-natriuretic peptide levels were seen while receiving ATRA 1 week on and 1 week off, respectively, during the maintenance phase of therapy.


Right subhepatic abscess after cesarean section.


Successful treatment of acute dapsone intoxication using charcoal hemoperfusion.


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


Skin lesions were located at the site of entry of bacteria (apocrine areas in 12 patients).


Various treatment modalities, such as an epidural blood patch, use of glue, removal of catheter, and surgical closure of dura and subdural blood patch, have been reported previously.


Early recognition of this rare syndrome, supportive management and withdrawal of the offending agent appear to result in a reversal of the manifestations described.


CASE SUMMARY: A 61-year-old white male patient (weight, 90 kg) was diagnosed with CML in March 2006 at the Division of Hematology, University of Rome "Tor Vergata," Rome, Italy.


Three and a half years after cessation of any medical treatment he developed anemia, thrombocytopenia and a diagnosis of acute lymphocytic leukemia (ALL) was made.


A pelvic form of the disease, associated with the use of Intra-uterine Devices (IUD), can severely damage pelvic organs and even can lead to death.


Antiretrovirals from three drug classes, nucleoside analogs, nonnucleoside analogs, and protease inhibitors, can be combined to achieve viral suppression.


A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia.


The child was referred to the Hippokration General Hospital, Thessaloniki, Greece hospital with steroid-resistant NS; renal biopsy was performed, which did not show any remarkable findings and cyclosporine was administered in addition to steroid therapy.


Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia.


Most symptoms resolved within several days, but tongue thrust continued until 6 months of age.


We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy.


Due to BC's resistance to currently used antifungal agents, this infection represents a therapeutic challenge and serious complication in the treatment of hematology malignancies.


Disulfiram is used commonly as reinforcement in the treatment of chronic alcoholism.


Limits to the "benefits" from our oncologic interventions: a case report.


Hormone therapy in men and risk of cardiac allograft rejection.


At discharge she had no symptoms of heart failure.


These cases highlight the occurrence of livedo reticularis as an uncommon side-effect of interferon alpha treatment.


Bacteremia due to Enterococcus avium.


Despite a long-time antibiotic therapy two further episodes of staphylococcus aureus sepsis occurred after discontinuation of CyA treatment.


Generalized cryptococcosis with CNS involvement was diagnosed in a 3-year-old spayed German Shorthaired Pointer.


T-cell receptor rearrangement analysis identified a monoclonal T-cell infiltrate.


We recommend the use of benzodiazepin as a premedication drug to reduce stress during dental treatment.


Disseminated histoplasmosis complicating bone marrow transplantation.


Hemolytic uremic syndrome following Campath-1H induction.


Ischaemic colitis in a patient taking meloxicam.


Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.


Coincidental with this treatment, the immunopathology of the glomerulonephritis improved dramatically, dramatically, renal function returned almost to normal, and both antinuclear antibody and LE cell preparation became negative.


BACKGROUND: Chronic myeloid leukemia (CML) is a myeloproliferative disorder primarily characterized by the presence of the Philadelphia chromosome resulting from a reciprocal translocation between the long arms of chromosomes 9 and 22.


Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.


We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.


Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


She had precordial ST-segment elevation characteristic of acute myocardial infarction and elevated cardiac biomarkers.


Candida sepsis developed during central total parenteral nutrition, at the age of 76 days.


We present a series of 9 MM patients who developed ONJ after treatment with bisphosphonates and chemotherapy.


Serum potassium was almost always normal.


METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.


On hospital day 5, as no additional arrhythmias had occurred, lidocaine was discontinued.


There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.


Semiquantitative measurements of cytokine mRNA in his bronchoalveolar lavage cells prior to therapy with IFN-alpha revealed high levels of IL-4 and IL-10 mRNA, which decreased significantly with treatment.


The patient was discharged five days after admission and referred to a hematology clinic for follow-up.


Continuous infusions of thrombolytic agents were used in both patients for approximately 24 h.


Overall, this indicated a reduced intracortical inhibition during hormonal therapy.


The possibility of severe rhabdomyolysis should be considered in a patient with water intoxication due to massive ingestion of caffeine-containing beverages.


Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency.


Large dose of methylphenidate may cause cataract and glaucoma.


Although praziquantel administration may have been effective in killing the parasite in both patients, we are concerned about the production of marked inflammation as a result of treatment.


An investigation of clozapine in the treatment of acute and chronic schizophrenia and gross behaviour disorders.


The patient's condition progressively improved to full recovery.


The Center for Disease Control has received numerous reports of an eosinophilia-myalgia syndrome related to products containing L-tryptophan.


Successful management of infusion reaction accompanying the start of cetuximab therapy.


This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.


A 9-year-old boy developed acute renal failure following intravenous acyclovir (30 mg/kg per day) administered for 6 days to treat herpetic encephalitis.


A small initial dose of prazosin ranging from 0.5 to 1 mg has been recommended to avoid the first-dose phenomenon characterized by a sudden and severe drop in blood pressure after the administration of the first dose of prazosin.


Is eczema herpeticum associated with the use of hot tubs?


Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use.


Bone marrow examination showed a generalized hypocellular picture, suggestive of drug-induced bone marrow suppression.


Six patients had bacterial pneumonia, one had acute cholecystitis, and none had a previous history of heart disease.


Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.


In the same period, healthcare professionals submitted 10 635 reports, concerning 16 722 ADRs.


A case of priapism associated with trazodone is described.


This is the first reported case of giant cell lichenoid dermatitis in a patient with baboon syndrome.


Gliclazide-induced acute hepatitis.


Psycho-pharmacotherapy for anxiety and obsessive-compulsive disorder: the issue of prolonged barbiturate retention.


He had been found to have pathologic findings of usual interstitial pneumonia (UIP) on the resected lung cancer specimen prior to receiving erlotinib.


BACKGROUND: Copaxone (glatiramer acetate) is a synthetic copolymer mimicking a portion of myelin basic protein, one of several putative autoantigens in multiple sclerosis (MS).


Back pain and opioid seeking behaviour.


Three eyes had a UCVA of 20/20(-2) or better and a BCVA of 20/20(-1) or better.


This is the first report of evaluating the urinary 6beta-hydroxycortisol/cortisol ratio in a case of porphyria.


As the patient's pulse rate increased, the symptoms of congestive heart failure disappeared.


Rare side effects of nonsteroidal antiinflammatory drugs are recognized with increasing frequency.


They no longer need red cell transfusions and have had a normal Hb concentration and normal ferrokinetics.


Chemotherapy induced myocardial fibrosis.


OBJECTIVE: The study was carried out to increase awareness about the etiology and characteristic features of pseudoporphyria.


Further refinements for customization of articulating spacers have been attempted (Rand 1993, Goldman et al. 1996).


OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.


One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.


Case report: persistent cytomegalovirus (CMV) infection after haploidentical hematopoietic stem cell transplantation using in vivo alemtuzumab: emergence of resistant CMV due to mutations in the UL97 and UL54 genes.


Atenolol induced memory impairment: a case report.


This report centers on a patient who developed a disrupted catheter secondary to a high pressure side port injection.


We report a case of myasthenia gravis in which the calcium channel blocker-nifedipine caused the worsening of the symptoms.


We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.


The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.


The subject developed fever and peripheral blood neutrophilia.


This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.


Ultimately, diabetes was controlled by dietary therapy alone despite reintroduction of risperidone.


IMPLICATIONS: Oral Ketamine, an NMDA receptor antagonist, can be used to treat restless legs syndrome.


Clinical awareness, timely detection and discontinuation of gemcitabine are mandatory to prevent this rare but disastrous complication of gemcitabine therapy.


Although PTLDs are usually Epstein-Barr virus-driven B-cell lymphoproliferations, T/natural killer-cell lymphoproliferations, multiple myeloma, and Hodgkin's lymphoma are also recognized as part of the PTLD spectrum.


The potential for severe toxicity in the setting of pediatric overdose should be recognized.


Pancreatic stones in 30 patients not treated with trimethadione neither disappeared nor diminished spontaneously.


Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.


A 43-year-old patient with preexisting mitral valve prolapse and Cardiobacterium hominis endocarditis with partial destruction of the posterior mitral valve leaflet is described.


We describe a case of a female who developed haemosiderosis, in the course of treatment for very severe unstable aplastic anaemia for fourteen years.


His platelet count was normal on admission.


Slight involution of the goiter within seven months may be attributed either to colchicine therapy or to treatment with levothyroxine and iodide.


Four children received ten alternate-day courses of ATG (horse antihuman thymocyte globulin) as well as antihistamines and corticosteroids to minimize allergic reactions.


Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.


Vicks VapoRub induces mucin secretion, decreases ciliary beat frequency, and increases tracheal mucus transport in the ferret trachea.


Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.


Rhodococcus equi is a bacterial pathogen of domestic animals that can infect immunocompromised patients, especially those with impaired cellular immunity, such as transplant recipients.


Desensitization to hydroxychloroquine--experience of 4 patients.


Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.


On admission at the Emergency Department, a microhematuria and a severe anemia were also documented.


Ultrasound-guided stellate ganglion block successfully prevented esophageal puncture.


SETTING: Private retina practice.


OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.


Osteonecrosis has been well-documented in the past.


We report the case of a young man, affected by rheumatoid arthritis who developed a rapid-onset short-of-breath, hemoptysis, and severe weakness, about 2 weeks after the administration of leflunomide.


Quetiapine-induced leucopenia and thrombocytopenia.


A 62-year-old man had received perhexiline maleate for 18 months before death.


Contributory factors probably included pharmacokinetic interactions with co-administrated drugs, vitamin K deficiency caused by decreased dietary intake, reduced gut bacterial production, impaired intestinal absorption and hepatic synthetic capacity, and increased consumption of clotting factors.


Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.


OBJECTIVE: To highlight ciclosporin as a therapeutic option in the treatment of steroid-responsive sudden SNHL.


This incidence was significantly lower (P less than 0.01) than that for 3CPs (four of 10 patients) or that for TMA (six of 17 patients).


RESULTS: Grade 3 and 4 toxicities were mainly hematological and manageable.


Symptomatic air trapped in the spine after lumbar epidural corticosteroid injection.


However, the possibility of cancer-associated MAHA could not be excluded.


Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


Risperidone for control of agitation in dementia patients.


The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.


A recent article has reviewed complications associated with interventional procedures and concluded that the complications were due to deviation from a specific prescribed protocol.


CONCLUSIONS: Placement of a central venous catheter for infusion therapy, chemotherapy and blood sampling has improved the quality of life of cancer patients.


With current donor evaluation protocols, the risk of transmitting infections by exogenous contaminated grafts seems to be more frequent than true donor-transmitted infections.


A 7-year-old castrated male Whippet developed deep ulcerative skin lesions whilst receiving immunosuppressive doses of prednisolone and cyclosporine for the treatment of immune-mediated haemolytic anaemia.


Although with current ulcer therapy (H-2 blockers, omeprazole, and sucralfate), the frequency of milk-alkali syndrome has decreased significantly, the classic triad of hypercalcemia, alkalosis, and renal impairment remains the hallmark of the syndrome.


After 2 weeks' off therapy, a partial reduction in mammary gland enlargement, local pain and erythema was observed.


With continuing fall in PSA, the patient had unequivocal progression of disease seen on bone scan.


Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.


Based on the findings, a high-grade endometrial stromal sarcoma was diagnosed.


The cutaneous reaction remitted after withdrawal of captopril therapy.


Eighteen tablets (72 mg) of her tiagabine prescription were missing.


We present a patient who had undergone renal transplantation referred for recurrent sinusitis.


Infections demonstrated RE blockade and failure of TSAT to reach target range.


Acute asthma associated with sustained-release verapamil.


Dementia with Lewy bodies (DLB) has been associated with important behavioural disturbances, such as psychotic symptoms.


Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.


CASE REPORT: A patient who underwent renal transplantation because of end-stage renal disease of unknown origin was shown to have a nocardial brain abscess while she was taking immunosuppressive drugs.


Reversible valproic acid-induced dementia: a case report.


Nocardia is an important opportunistic infectious agent in immunocompromised hosts, i.e. in patients taking corticosteroids.


The hemangioma regressed markedly 6 weeks after the procedure and serous retinal detachment showed marked resolution.


Vocal cord paralysis as a consequence of peritonsillar infiltration with bupivacaine.


AO images showed disruption of the cone photoreceptor mosaic in areas corresponding to HVF 10-2 defects and SD-OCT IS/OS junction abnormalities.


No problems have been observed during desensitization.


After calling the salon and consulting Poisindex, the substance was found to be Mar-V-cide, containing 20% Hyamine 3500, 50% cationic detergents, 20% isopropyl alcohol, and 1% sodium nitrite, which caused the methemoglobinemia in this case.


There was complete recovery of hair loss and the regrowth started after 12 weeks of alopecia.


Despite discontinuation of the local anaesthetics, the symptoms persisted.


METHODS: Five patients with recurrent haze after myopic PRK were retreated with phototherapeutic keratectomy and topical thiotepa.


The allergological work-up was negative, except for intradermal test with gelatine.


After 6 weeks of therapy, the patient developed an unexplained fever.


FSGS induced by Adriamycin (Pharmacia & Upjohn, Columbus, OH) has been observed experimentally in rats.


Gemcitabine-related radiation recall in a patient with pancreatic cancer.


Progressive improvement was also seen in all the parameters on Pentacam scans, including the pachymetry, keratometry readings, and elevation on the anterior float.


Cardiovascular disease is the leading cause of death in patients with diabetes mellitus and represents a persistent risk that is inextricably linked to the diabetic disease state.


We report the results of treatment with MACOP-B in 11 young patients with low grade lymphoma (LGL).


The clinical course suggests that the interstitial pneumonitis was induced by hydroxyurea.


All lesions resolved with proven histologic clearance.


The first two cases received ASCT for MM, one with a CD34-selected autograft and the other with an unmanipulated autograft.


METHODS: The medical records of 8 neonates treated with rFVIIa (100 micro g/kg) were retrospectively reviewed for the course of hemorrhage and the hemostatic interventions performed before and up to 24 hours after the administration rFVIIa.


The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.


Both epidural fat deposition and vertebral compression fractures are among such complications.


The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.


Animal studies that predated clinical trials using rhesus monkeys did not predict the ophthalmologic complications seen in human subjects.


METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.


To our knowledge, this is the first report of M. marinum occurring in a patient receiving infliximab.


Urine collections and serum samples yielded normal levels of uro- and coproporphyrins.


However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.


Eleven days after TAE, he developed suppurative cholangitis and multiple organ failure.


A case report and review of the literature.


When they do occur they are rarely a clinical problem.


After the surgery a Pet scan was positive for a hot-spot in the left colon.


Because sumatriptan can cause coronary artery vasospasm, patients with significant risk factors for coronary artery disease should be carefully evaluated for cardiovascular disease prior to the use of sumatriptan.


A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl).


Ballistic movements ceased after administration of haloperidol; both patients remained without abnormal movements thereafter.


The first case of early-onset postsplenectomy arthritis due to intermediately penicillin-resistant Streptococcus pneumoniae is reported.


We report a 31-year-old women with recurrent Hodgkin's lymphoma and unrecognized HMSN-1 who developed severe motor neuropathy 3 weeks after the first cycle of treatment including 2 mg of vincristine.


After a short course of low-concentration miotic therapy, the adhesions were broken.


A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.


PFGE for typing of C. dubliniensis was developed and the necessity of long-term antifungal therapy is discussed.


There are no human data regarding the safety of very high dosages of lacosamide.


The type of lung toxicity was similar to the one observed with other antitumor antibiotics.


Hepatolithiasis is uncommon in western countries but is quite prevalent in East Asia and is often associated with a predisposing condition that causes intrahepatic bile stasis (eg. bile duct stricture).


SETTING: Outpatient pain clinic associated with a university hospital.


The spectrum of renal lesions occurring during antituberculous therapy, particularly in association with rifampin, may be wider than previously suspected.


Amiodarone was discontinued after discussion with the cardiologist.


Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.


Cerebral infarction due to an embolism after cervical pedicle screw fixation.


Imatinib-induced tumor lysis syndrome: report of a case and review of the literature.


A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.


Although molecular mechanisms have not been fully elucidated, Epstein-Barr virus appears to play a significant role in its etiopathogenesis.


CONCLUSIONS: We report a typical symptoms of Charles-Bonnet syndrome (CBS) in patients with severe AMD after intravitreal Avastin-injections.


The patient recovered without sequelae with conservative therapy.


An attempt also was made through case analysis to examine the association between dynamic aspects of personality and adverse drug effect.


Although his renal function recovered completely with high-dose leucovorin, hemodialysis, charcoal hemoperfusion, and carboxypeptidase G2, we present this case to emphasize that signs of renal toxicity may be present as early as 2 hours after the completion of a 4-hour MTX infusion, and to suggest that monitoring for MTX toxicity should perhaps begin within a few hours after the completion of 4-hour MTX infusion.


Corticosteroids and azathioprine are considered standard treatment for autoimmune hepatitis.


He had skin and bone involvement and some of the leukaemic blasts showed haemophagocytosis, characteristic features seen in t(8;16) AML.


The absence of hyperplasia in the progestin-treated endometrium suggests that the squamous metaplasia does not represent persistence or progression of the original hyperplastic lesion.


CONCLUSIONS: For all patients with vancomycin-induced neutropenia, possible cross-reactivity of teicoplanin should be monitored.


A case of isolated Nocardia asteroides brain abscess in a kidney transplant recipient.


This deterioration started 3 months post-treatment and worsened over the ensuing 4 years.


Here is a case report on acute myelogenous leukemia, which developed after 63 months following the completion of treatment with surgery and platinum-based chemoradiation in a patient of carcinoma cervix IB.


Breast-feeding was terminated, and the infant fully recovered.


Neither blood culture samples nor computed tomography and magnetic resonance imaging of the chest and abdomen nor a trans-esophageal echocardiography revealed positive results.


Serotonin syndrome.


CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.


MATERIALS AND METHODS: In a retrospective analysis during a 5-year period, 112 patients underwent stent-graft placement for thoracic aortic aneurysms.


An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.


Two patients with refractory seizures failed to respond to anticonvulsants, and their seizures were controlled only after parenteral pyridoxine.


CASE REPORT: We report a patient who developed a DAT-positive hemolytic episode after a red cell (RBC) transfusion was delivered during the infusion of her 17th cycle of oxaliplatin.


The patient failed to respond to intravitreous, subconjunctival, and systemic amphotericin B, and the eye was enucleated.


Obstruction from such a cause may be prevented by including non-constipating antacids, stool softeners or sorbitol.


One patient was a 21-day-old infant who received 2 days of induction chemotherapy for the treatment of congenital Stage IV-S neuroblastoma.


SUMMARY OF BACKGROUND DATA: Several different causes of postoperative neurologic deficit have been reported in the literature.


The increased interest in the use of neoadjuvant chemotherapy for patients with locally advanced or large tumors at initial presentation necessitates the recognition of sequelae of this therapy.


The patient remained asymptomatic up to the diagnosis.


Hyperglycemia and diabetic coma: possible relationship to diuretic-propranolol therapy.


A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.


Although several adverse effects are associated with this drug, it has only rarely been known to exacerbate seizures.


The precise role of testosterone in regulating mood, especially in alleviating depression, remains unclear although converging evidence indicates that androgens may exert antidepressant action.


PURPOSE: Posterior hyaloid adherences play a role in the pathogenesis of diabetic macular edema (DME).


Although there are very few prospective data on the efficacy of treatment of drug-induced AIN, corticosteroids may have a role in recovery of renal function.


Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.


Case 2: A 43-year-old male alcoholic remained completely abstinent with cyanamide treatment for 5 years and complained of general fatigue.


We report a patient who presented with a left proximal deep vein thrombosis at 25 + 5 weeks gestation.