Unexplained menorrhagia and hematuria occurred in a 13-year-old female with a mild inherited platelet disorder who had never experienced prior bleeding as a result of this disorder.


Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.


Coronary artery spasm usually responds to sublingual nitroglycerin.


We present the case of a female with DDST, who responded to aripiprazole-mirtazapine combination, a finding that is in accordance with the initial approach of this disorder as a part of the schizophrenic spectrum, but also supports the hypothesis of serotonin dysfunction in DDST.


The postoperative histological diagnosis was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma.


Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.


The possibility that the underlying disease or other chemotherapeutic agents may increase the risk of pulmonary toxicity can, however, be discussed.


Total excision of the lesions with concomitant four-combined antituberculous therapy proved successful.


The daily carboplatin dose was calculated based on the Calvert formula, using a target area under the plasma concentration-time curve (AUC) value of 3.25 mg.min/ml and applying the Cockcroft-Gault equation to estimate the glomerular filtration rate.


To the best of our knowledge, this patient is the youngest, and only the fourth person in the English-language literature to develop colonic carcinoma after combination chemotherapy of Hodgkin's disease without radiation.


Probabilistic analysis of decision trees using symbolic algebra.


Advantages of treatment of hypertension with Minoxidil.


CONCLUSIONS: We reported the association of multiple sclerosis and intracranial meningioma and observed the progression of the meningiomas during interferon treatment.


PURPOSE: Platinum-based therapy is the cornerstone of ovarian cancer treatment.


Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.


In reviewing the literature, the authors discuss the currently available therapies for such infections of the spine, and highlight the growing incidence these and other formerly rare infections.


Eosinophilic peritonitis responding to treatment with glycyrrhizin.


Thus, the patient's clinical course and workup strongly support a diagnosis of lenalidomide-induced hypersensitivity pneumonitis-like syndrome.


We report two new cases of sarcoidosis in two patients with hepatitis C virus infection treated with interferon alfa and ribavirin.


The mechanism of the reaction and guidelines for subsequent use of cyclosporine are not well defined.


Further studies are needed to evaluate the pathogenesis of cystoid macular edema and determine whether vascular endothelial growth factor blockade should be included in treatment modalities for this condition.


Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.


Therefore, we believe that screening for HBsAg is insufficient for detecting latent HBV carriers, and that investigation for hepatitis B core antibody (HBcAb) is essential.


The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.


All three patients had clinical courses characteristic of RS and two had supportive histologic findings on liver biopsy.


Diagnosis of transfusion-associated graft-versus-host disease by polymerase chain reaction in fludarabine-treated B-chronic lymphocytic leukaemia.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Fatal fluoxetine ingestion with postmortem blood concentrations.


To eradicate the infection, we performed two vitrectomies and treated the patient with numerous intravitreal antibiotic injections.


Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.


The baseline population risk of malformations is 3-5%, but it increases to almost 30% in women exposed to isotretinoin during the first trimester of pregnancy.


Psoas abscess following ileo-anal pouch surgery.


This unprecedented phenomenon may be due to antiretroviral therapy.


The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.


An objective causality assessment revealed that the adverse drug event was probable.


The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.


All children showed a major clinical improvement within three months despite concomitant reduction of the prednisone dose.


Nine days later, severe abdominal pain developed.


In each case, the decline in free SDC was temporally related to the resolution of digoxin toxicity; in one case, digoxin intoxication recurred and was associated with a rebound increase in free SDC.


The long-acting somatostatin analogue octreotide (LAR, 30 mg/month, i.m.), was started, and after 2 weeks diarrhea decreased and gradually disappeared.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


It emphasizes the need for close surveillance of renal function and blood pressure during such therapy even in patients with relative preservation of renal function.


After positioning of a 0.035 inch guidewire proximal to the biliary stricture, the preloaded catheter was advanced over the guidewire by using the monorail technique.


Careful donor evaluation before transplantation, unusually early presentation of mycosis leading to anastomotic renal artery disruption, the histopathologic findings of the grafts, and the absence of Candida infection in the liver and heart recipients make us believe that exogenous contamination of the grafts occurred during donor procedure, kidney processing, or at transplantation.


Three patients never had intubation during hospitalization.


The patient developed abdominal pain and high fever on Day 21 after the initiation of chemotherapy.


This is the first described case of acute gouty arthritis after RFA for a HCC lesion in a patient with underlying chronic renal insufficiency.


The elicitation of a movement disorder by trazodone: case report.


Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children.


The spectrum of antimicrobial activity of albendazole and its efficacy in the treatment of intestinal microsporidiosis are reviewed.


CONCLUSION: Patients receiving inhaled morphine should be closely monitored and resuscitation equipment should be readily available.


When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.


All biopsies were studied by the same pathologist.


The isotretinoin, a 13-cis-retinoic acid, has revolutionized the management of severe treatment-resistant acne and it has been widely used for a range of dermatological conditions, in 90% of the time in young women between 13 and 45 years of age.


In three patients, occasional transient episodes of atrial flutter or atrial fibrillation preceded a spontaneous return to normal sinus rhythm.


Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.


Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.


Cisplatin administration following carboplatin desensitization failure in primary peritoneal cancer: a brief report.


The increasing number of doses administered worldwide has revealed rare but important adverse effects that had not occurred during clinical trials.


We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


We encountered two cases of acute pancreatitis in patients with Cushing's disease following transnasal transsphenoidal hypophysectomy.


In contrast to two other reported cases, our patient was not overtly immunosuppressed.


OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.


Infiltrative ophthalmopathy and primary hypothyroidism: a rare clinical manifestation of a common disease.


This side effect appears to be a universal property of effective antidepressants, including this new, purely serotonergic agent.


Treatment of acute necrotizing pancreatitis (ANP) after TACE is the same as the accepted approach to ANP due to other causes.


Dysphagia, though uncommon, can be quite debilitating and can mimic a paraneoplastic syndrome.


Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.


Biopsy specimens showed atypical lymphoid cell infiltration.


Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.


Standard PSG recording and scoring methods were employed.


An unusual complication of a Hickman catheter.


The reaction was thought to be triggered by the combination of radiation and epidermal growth factor receptor tyrosine kinase inhibitors, which may be responsible for hypersensitizing the radiation response in normal tissue in the unique individual.


Antimycobacterial treatment, which led to a dramatic improvement within two months, was protracted for 18 months until the complete return to normal of both clinical and laboratory findings.


The possible causal relationship between prolonged estrogen administration and breast cancer in males is in contrast to available epidemiologic data.


We here report on 3 patients with essential tremor, otherwise unresponsive to pharmacological treatment, who greatly benefited from low doses of topiramate (50 mg/d).


He was subsequently followed on a regular basis with repeated measurement of lead levels in blood and bone (using a K-x-ray fluorescence instrument) as well as clinical parameters.


Despite treatment with corticosteroids, she had rapid deterioration and died of respiratory failure.


Profound muscle weakness of lower extremities with inability to stand up and/or walk was present.


Because corticosteroids may induce several psychiatric symptoms, psychotropic drugs are required to treat these symptoms in some cases.


Azathioprine withdrawal resulted after 7 weeks in the resolution of clinical and biochemical abnormalities.


All the lesions showed high attenuation relative to muscle on the precontrast CT and showed positive findings on PET/CT.


He was initially diagnosed with chronic lymphocytic leukemia (CLL) and treated with six cycles of fludarabine, cyclophosphamide, and rituximab chemotherapy.


Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.


Chronic inflammatory demyelinating polyneuropathy associated with tumor necrosis factor-alpha antagonists.


Amphotericin B-induced cutaneous leucocytoclastic vasculitis: case report.


Prophylactic administration of thiabendazole is probably preventive.


Necrotizing leukoencephalopathy and treated multiple myeloma.


Liposomes have been proposed as an effective way to target drugs at macrophages, which are the cells infected in visceral leishmaniasis.


A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.


We treated her hyperthyroidism with amiodarone (average daily dose, 200 mg) for 3 weeks, achieving rapid and persistent euthyroidism, (triiodothyronine [T(3)] levels ranged between 64 and 109 ng/dL) without side effects.


Hepatic damage after danazol treatment.


We describe a 57-year-old woman with acute lymphoblastic leukemia who had a cavitary lesion develop in the right upper lobe caused by Cunninghamella bertholletiae, a zygomycete.


It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.


We report two cases of uncommon pathological reactions, one resembling a hypersensitivity pneumonitis and the other mimicking a giant cell interstitial pneumonia.


The mechanisms are not clear, and peripheral (case 1) and also central pathways (case 2) could be involved.


For all recipients with neurologic complications, we reviewed clinical findings, imaging and electrophysiologic test results, and perioperative laboratory data.


Fatal exacerbation of paraneoplastic systemic sclerosis after neoadjuvant chemotherapy in a breast cancer patient.


We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.


Near fatal acute colchicine intoxication in a child.


Prevention, early recognition of the clinical presentation, identification and removal of the offending agents, supportive care, and specific pharmacologic therapy are all important to the successful management of serotonin syndrome.


We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).


The possible effects of tamoxifen upon the uterus are discussed in this article, in view of reports of tamoxifen associated with endometrial carcinoma and endometriosis.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


All patients underwent radiological investigation for tumour staging and comparison with the following study in accordance with the protocol in place at our Department of Oncology and Division of Diagnostic Imaging.


Histopathological features were also consistent with the disease.


We describe a patient who presented with autoimmune hemolytic anemia and small bowel obstruction secondary to a malignant stromal tumor (leiomyosarcoma) of the jejunum, 25 years postchemotherapy and radiation treatment for stage IIA Hodgkin's disease.


Opioid analgesics were the most common therapy (81%).


A fatal case of theophylline intoxication.


Reports on such manifestations in relation to hepatitis B vaccination are scarce, however.


Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.


Although follow-up is short, radiotherapy alone appears to provide excellent disease-free survival.


These cases and a review of the literature suggested that hepatotoxicity, though rare, should be added to the list of adverse reactions to D-penicillamine.


A few limited literatures about this disease strongly recommends steroid therapy for treatment.


Abdominal pain and obstructive symptoms concomitant with weight loss are the common presenting complaints.


First trimester disulfiram exposure: report of two cases.


Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.


In studies addressing this issue, there appears to be no real problem with increased severe episodes of hypoglycemia in patients on beta-blockers or increased hypoglycemic unawareness.


RESULTS: All seven children are alive and without evidence of tumor with a median follow-up of 30 months (range, 18-35 months) from diagnosis.


Liver abscess caused by ventriculoperitoneal (VP) shunt is very rare.


Rechallenge with a different beta-lactam antibiotic has not been shown to consistently cause recurrent leukopenia.


Three case studies are the basis for a discussion of the criminalization hypothesis as it may apply to psychiatric probationers and parolees in the criminal justice system.


The absence of eosinophils does not exclude the possibility of a minocycline cause.


In all five patients, sodium loading was associated with improved renal function, which permitted amphotericin B therapy to be continued in fully effective doses to the completion of elective courses of treatment without evidence of residual impaired renal function.


TREATMENT AND OUTCOME: The mare was treated with gabapentin (2.5 mg/kg [1.1 mg/lb], PO, q 12 h).


Rechallenge with varenicline while the patient continued to receive amphetamine-dextroamphetamine yielded similar results.


Case studies in heparin-induced thrombocytopenia.


Patients were monitored for adverse treatment effects.


One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.


Patients receiving these agents are at risk of acute or subacute pulmonary damage.


Antimicrobial treatment was changed to tigecycline and continued for suspected pleural space infection.


Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea.


All-trans retinoic acid and short-time, high-dose cytarabine in two children with acute promyelocytic leukemia.


Tardive seizure and antibiotics: case reports and review of the literature.


Reduction of postoperative pain is an important goal in the perioperative management of tonsillectomy patients.


Liver disease was diagnosed 12 +/- 4 years (range, 8-18) after initiation of antiretroviral therapy (ART).


Reactivated herpetic keratitis following laser in situ keratomileusis.


Furosemide, spironolactone, allopurinol, and hydroxyurea were considered possible causes of the reaction and were discontinued.


DISCUSSION: Cutaneous IL-2 adverse effects are frequent, but generally mild and reversible.


We report the case of a man, treated with mesalazine for Crohn's disease who developed drug-induced pericarditis.


We conclude, this novel mode of intra-operative local chemotherapy by spray application of fibrin glue containing antineoplastic agent is effective in the control of residual tumor progression and may also prevent local recurrence and hence suggests its possible role as an adjuvant therapy in the management of malignant gliomas.


Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.


Asthma and dental erosion.


Cimetidine, an H2 blocker, may partially abolish the effect of tolazoline.


We postulate that the patient's hearing loss was the result of ketoralac's direct and indirect ototoxic effects that were potentiated as a result of her underlying illness and medications.


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.


Osteonecrosis of the maxilla as a complication to chemotherapy: a case report.


Resistance to combined ganciclovir and foscarnet therapy in a liver transplant recipient with possible dual-strain cytomegalovirus coinfection.


Fatal lung fibrosis caused by paclitaxel toxicity has not been reported In this report, we describe the case of a 62-year-old woman who received six cycles of paclitaxel and carboplatin as combination chemotherapy for advanced ovarian cancer.


Lamotrigine toxicity secondary to sertraline.


Percutaneous drainage of the liver abscess and externalization of the VP shunt were performed.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


Radiation recall resolved spontaneously with withdrawal of gemcitabine.


Her response to a postural challenge test, without medication, was normal.


Neutropenia is an uncommon but potentially serious complication of drug therapy.


After stopping indapamide, glucose tolerance impairing may be reversed.


Discontinuation of the ACE inhibitor results in rapid alleviation of the cough, although this is not always necessary, as most patients may experience a cessation or decrease in cough.


A healthy 62-year-old woman was referred to our dermatology department with a 1-month history of a pruritic axillary eruption.


Subsequent in vivo/vitro studies clearly demonstrated that the neurological effects were due to a synergistic action of desferrioxamine and prochlorperazine, probably resulting in exceptional fluxes of intra/extra cellular iron/copper disturbing noradrenergic and serotonergic systems.


Long-term, controlled studies are required to specifically address this issue.


After 3 h of hemodialysis, her post-dialysis acyclovir level was 1.9 micrograms/ml.


Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.


Four cycles of this protocol yielded a dramatic response on re-staging CT scan.


Her acyclovir level was later found to have been 3.4 micrograms/ml (normal peak range 0.4-2 micrograms/ml) prior to dialysis.


In vivo confocal micrographs showed the double-walled structure of the Acanthamoeba cyst and associated radial keratoneuritis (perineuritis).


Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates.


Therefore, the possibility of an association by chance cannot be ruled out.


This ubiquitous inhabitant of the sebaceous glands and hair follicles can cause acne vulgaris.


The coexistence of acute myeloid leukemia (AML) and CLL in the same patient has been occasionally reported.


CASE SUMMARY: An 85-year-old white man presented with an upper gastrointestinal hemorrhage from a gastric ulcer.


Although leukemia after liver transplantation is generally thought of as a rare complication, increases in survival rate following liver transplantation is likely to lead to more such cases, and documentation of these cases is therefore of importance.


CONCLUSION: Zidovudine is well a known cause of anaemia and thus should be used with caution in the initiation of antiretroviral therapy.


INTERVENTIONS: Patients were treated with 4 to 8mg of cyproheptadine by mouth every 6 to 8 hours, 5 to 10mg of diazepam by mouth every 6 to 12 hours, 10 to 20mg of baclofen by mouth every 6 hours, and ITB boluses in some cases.


STUDY DESIGN: Case report.


Crumley).


The biochemistry of paracetamol hepatotoxicity is outlined and the increased susceptibility of alcoholic patients to the hepatotoxic effects of paracetamol is remarked upon.


We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.


Both premortem and postmortem bone marrow sampling revealed almost complete replacement of the marrow space by sheets of histiocytes demonstrating metachromatic cytoplasmic granules.


This is the first report to describe this extremely rare occurrence.


In general, it is good medical practice to avoid concomitant administration with centrally acting anticholinergic agents.


We report a case of fatal fulminant hepatitis caused by the use of disulfiram in a man with previously normal hepatocellular function.


Both of the previous patients had therapy-related leukemias after exposure to topoisomerase II inhibitors, whereas our patient had received cytotoxic therapy that did not include a topoisomerase II inhibitor.


Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.


Treatment requires management of both the liver abscess and the infected shunt.


Ten hours later, the patient developed myoclonus of his upper extremities and face.


Five of nine cases developed in patients with significant gastrointestinal illnesses.


A 40-year-old Hispanic man with acute lymphoblastic leukemia was treated with a single dose of intrathecal methotrexate 12 mg for prophylaxis against leptomeningeal spread of tumor.


Shortly after mitral valve replacement she developed a severe hypercalcemia (serum calcium 5.95 mmol/l) during a febrile illness.


Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.


Alopecia is an adverse effect in those patients taking aromatic anti-convulsant drugs but is rarely reported after discontinuing such medications in the convalescent status of anti-convulsant hypersensitivity syndrome (AHS).


She had taken no drug except for the IFN-beta-1b.


Several cases of lithium-induced Creutzfeldt-Jakob syndrome have been reported to date; all of them were elderly patients and a half had "therapeutic" lithium serum levels.


Pathology evaluation of a specimen revealed a high-grade osteoblastic osteosarcoma.


We also describe a case of timolol-induced ocular pemphigoid.


Although it has been reported previously in patients being treated for lymphoma, it occurred in this case in a man under treatment for glomerulonephritis.


Another explanation for the decreased drug levels might be an increased volume of distribution.


Although guidelines for management have been developed, they may be predicated on data from a single institution or depend on diagnostic procedures and laboratory support that are not necessarily available to physicians in all locations.


We present foreign body granulomas induced by activated charcoal from intraperitoneal chemotherapy and mimicked peritoneal metastases in the patients with gastric cancer.


A case of superior sagittal sinus thrombosis associated with Evans' syndrome of immune haemolytic anaemia is reported.


Drug-induced thrombocytopenia was also considered, and he was told to stop all of his medicines.


This case report describes a non-cigarette smoking elderly woman who developed bronchial anthracostenosis and mediastinal fibrosis after long-term exposure to wood smoke.


Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.


Copaxone is a drug approved for the treatment of MS, and one that is very well tolerated with a high safety profile and relatively few side effects.


Over 12 months, the patient received six rather than 12 CY treatments, half the cumulative dose that might have been administered.


Pulmonary impairment in the HUS is rarely reported in the literature, and no reports of pulmonary hemorrhage, as a clinical feature of the HUS, have been documented.


METHODS: We describe a patient with MG and a steroid-induced major depressive episode with psychotic features treated with ECT.


This case report represents the successful usage of LS for weaning from cardiopulmonary bypass circulation after coronary artery bypass surgery.


Severe abdominal colic because of lead poisoning is an uncommon condition in adults.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


She recovered with shock therapy and intravenous administration of diphenhydramine and hydrocortisone.


In patients with GI GVHD clinicians need to be aware of the potential for oral absorption and, in select cases, monitoring of levels may be appropriate.


RESULTS: Six eyes had occult subfoveal CNV, and one eye had recurrent classic subfoveal CNV.


Evidence is shown in this report that adenosine was associated with dangerous worsening of arrhythmia in patients with atrial flutter.


There was no evidence of renal failure, diabetes, acidosis, increased potassium intake, or significant tissue trauma.


Actinomycin D associated hepatic veno-occlusive disease--a report of 2 cases.


In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.


To our knowledge, AVP following therapy with TNF-alpha antagonists has not been reported in English literature.


After 48 hours, improvement in the patient's respiratory symptoms allowed transfer to the ear, nose, and throat unit, where daily endoscopic examination was performed.


Serum triglyceride levels of four patients with psychotic disorders were decreased after switching therapy from clozapine to risperidone.


A 55-year-old woman who had been receiving treatment with amiodarone for recurrent supraventricular tachyarrhythmias became thyrotoxic after 30 months of treatment.


After 5 days of treatment with IL-2, the patient developed a hemorrhagic lesion that progressed to toxic epidermal necrolysis, as well as grade 4 pancytopenia.


The episodes of ocular dystonia were associated with other dystonic movements and a number of psychiatric symptoms, with obsessional thoughts and hallucinations being the outstanding features in one patient each.


There are few reports in the literature related to sulfonylurea-induced hepatotoxicity.


The clinical monitoring was based on the serial registration of respiratory rate, cardiac rate, SaO2 and body temperature.


Until this time, she was without any antidepressive medication.


He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.


CONCLUSIONS: This case describes the original development of a desensitization protocol to high-dose MTX.


At least three of these patients developed acute myelogenous leukemia (AML).


A 24-year-old woman with ALL developed severe epigastric pain 168 days after CBSCT, followed by blistering eruptions 2 days later.


Use of St.


Hypercoagulopathy induced by chemotherapy in a patient with lung cancer.


Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.


It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.


Their use on the face in severe atopic eczema is relatively common.


Gemcitabine-induced rectus abdominus radiation recall.


Incidence of seizures in pediatric cancer patients treated with imipenem/cilastatin.


The case of a myasthenia-like syndrome induced by cardiovascular drugs is reported.


In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.


We describe a patient with respiratory failure due to Wegener's granulomatosis (WG) who obtained a dramatic and sustained response to pulse intravenous methylprednisolone and cyclophosphamide.


Cluster headache (CH) is a well characterized primary headache disorder.


We propose a classification of cutaneous minocycline pigmentation based on clinico-pathological criteria.


Range orders should, for example, take into consideration the patient's age, pain intensity, and comorbidities; avoid frequency ranges; and prescribe a maximum dose that is at least two times but no more than four times the minimum dose in the range.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


Heparin-induced thrombocytopenia complicated with massive thrombosis of the inferior vena cava after filter placement.


Tamoxifen treatment is a proven therapy for breast cancer that produces a survival advantage when used as an adjuvant, and reduces the incidence of recurrences and controlateral tumor evolution.


A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.


If troglitazone is used, frequent monitoring of serum aminotransferases and symptoms is mandatory.


Vasopressors were required to support blood pressure for approximately five hours.


While our patient's second malignancy may have been a chance association, his and other cases of pancreatic carcinoma in young survivors of hematologic neoplasia suggest that the cytotoxic treatment may have had a role in the pathogenesis of the pancreatic carcinoma.


Primary Hodgkin's disease of the CNS in an immunocompetent patient: a case study and review of the literature.


It is rewarding to have the option to offer a medication that improves patients' status and enhances outcomes.


The patient was resuscitated, and subsequent serial cardiac enzymes indicated myocardial infarction.


Reversible nonthrombocytopenic palpable purpura associated with metoclopramide.


Increased awareness of this rapidly progressive and potentially fatal disease leads to accurate diagnosis and the prompt treatment that can decrease morbidity and mortality.


RESULTS: Complete clinical response was obtained in both patients.


Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma.


She was discharged with oral levofloxacin to complete an additional 3 days of treatment as an outpatient.


Electroconvulsive therapy and antibiotics: a case report.


She had Crohn's disease since age 9 years and was on chronic TPN.


In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.


Other explanations for an exaggerated and delayed response to opioids include co-administration of other respiratory depressant drugs such as magnesium sulphate, co-morbidity such as renal impairment and genetic variability in the metabolism of morphine.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


These studies indicate that gastrointestinal absorption of aluminum can lead to aluminum intoxication in children with azotemia, and that infants may be particularly susceptible to this complication of therapy.


Computed tomography and magnetic resonance imaging of the brain showed acute infarctions bilaterally in the cerebellum.


The patient developed cardiac arrhythmias, acute renal failure, and anemia.


Blastoschizomyces capitatus infection in acute leukemia patients.


DCF appears valuable as a second-line treatment in non-Hodgkin's lymphomas and as initial treatment in T-cell chronic lymphocytic leukaemia and mycosis fungoides.


Drug-induced psychosis is a serious late complication of Parkinson's disease (PD) that requires aggressive treatment.


After treatment with steroids there was gradual clinical improvement and disappearance of infiltrates.


We report a case of type III left anterior descending artery (LAD) perforation which was managed successfully with cyanoacrylate glue.


We described the occurrence of L-dopa-induced myoclonus and seizures in a case of parkinsonism with its SEPs findings.


Fatal acute tubular necrosis occurred in 1 patient in whom intravesical formalin was used to control massive persistent hemorrhage from radiation cystitis.


We present a depressive patient who developed mild parkinsonian signs and camptocormia after the introduction of olanzapine.


A recently recognized entity associated with the treatment of acute promyelocytic leukemia: the retinoic acid syndrome.


We describe our modified technique for custom-made articulating spacers.


METHODS: This was a prospective, open-label study.


A MEDLINE search did not identify any citation describing the possibility of an interaction between the drugs.


Therapy-related acute myeloid leukemia with 11q23 abnormality coexisting with refractory metastatic Ewing sarcoma: report of a case and review of the literature.


Severe complications following thrombolytic therapy of an acute thrombosis of a prosthetic mitral valve.


Leukaemoid monocytosis in M4 AML following chemotherapy and G-CSF.


This rare adverse reaction to TMP-SMX has been reported in adults; however, to our knowledge, it has been reported in only five other children.


Encephalopathy and seizures induced by intravesical alum irrigations.


CONCLUSION: The use of HDR radiation in these patients eliminated radiation exposure to care-givers and permitted constant nursing care and interaction among the parents, nursing personnel, and child.


Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.


CONCLUSIONS: TEN is a rare disorder that can be fatal in up to 30% of patients.


The vancomycin concentration was decreased from 101 mg/l to 16.59 mg/l at the end of the procedure.


The pharmacology and toxicology of chloral hydrate are discussed with particular reference to the cardiac arrhythmias that are seen with overdosage.


A wide variety of clinical outcomes have been described after acute valproate ingestion.


In the latter cases, it is commonly attributed to azathioprine and/or tacrolimus.


This infection was successfully eradicated after neutrophil recovery by prolonged systemic administration of amphotericin B as well as aggressive local therapy including enucleation of the affected eye.


To our knowledge, this is the first report of an angio-oedema associated with VRC.


OBJECTIVES: The authors examined the efficacy of highly selective CDT in late salvage of free-flaps with vascular compromise.


Recently, results of three open clinical trials on mycophenolate mofetil in myasthenia gravis have been reported.


These features were initially ascribed to the veno-occlusive disease caused by pyrrolizidine alkaloids, radiotherapy and some therapeutic drugs but have not been described in detail as a complication of AMD therapy.


Pulmonary thromboembolism after spinal instrumentation surgery.


An upper gastrointestinal endoscopy revealed reflux esophagitis and the patient was given 20 mg b.i.d. omeprazole.


We describe a 10-year-old boy with ulcerative colitis who developed acute pancreatitis while on long-term treatment with 5-aminosalicylic acid.


OBJECTIVE: The aim of this study was to evaluate the present status of surviving patients 10 years later, together with the latest clinical and histological data on patients who had died.


Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.


These cases emphasize the need for a high index of suspicion for tickborne illness in oncology patients, and the importance of a low threshold for starting empiric treatment before confirming the diagnosis.


Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.


A case of colchicine-induced rhabdomyolysis is reported.


INTRODUCTION: Fever of unknown origin is a complex problem in dialysis patients with recently rejected renal allografts, due to the contribution of the newly withheld immunosuppressive agents to the immunosuppression of uremia, resulting in an atypical presentation of infections, a main cause of fever in these cases.


RESULTS: Six preterm and 2 term patients were included in the study.


The possible pathophysiologic mechanisms for the adverse reactions include a single-drug effect, a pharmacodynamic interaction, and a pharmacokinetic interaction.


These cases demonstrate that CBZ can induce simple motor tics in children.


There has been relatively good organ growth and function during this short follow-up period.


We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.


A diagnosis of lead poisoning was made and a course of chelating treatment started.


The patient recovered completely with oral prednisolone.


Clofazimine enteropathy in a pediatric bone marrow transplant recipient.


In most patients with catheter-related Rhodotorula fungemia, the condition has been treated with broadspectrum antibiotics.


Significant systemic manifestations are rare.


He recovered and could be discharged home after 36 days of hospitalization with normal blood counts and without severe sequelae.


Our cases of monophasic, multiphasic and recurrent DEM, invoking possible causative triggers, point to the conclusion that DEM has to be regarded as a separate disease; its similarities with NMO raise the expectations that other specific autoantibodies will be identified to explain DEM and its variations.


After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.


Recovery was complete in two of three children.


This theory was supported by disturbances in serine and glycine excretion found in all patients during psychotic episodes.


INTRODUCTION: Tuberculosis is a rare but serious complication after transplantation.


This observation highlights the need for hemodynamic monitoring when potent vasodilators are used in this disorder.


The vasodilating action of calcium-channel blockers decreases the systemic pressure and in turn, may increase the pressure gradient and the left ventricular end-diastolic pressure.


Donepezil may be a valuable alternative to psychostimulants in the treatment of opioid-induced sedation.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


We report that perospirone may have had positive effects on the obesity of three patients with schizophrenia and on the fasting blood sugar (FBS) and HbA1C of two of them who had type 2 diabetes mellitus.


The efficacy and safety of fluticasone has been established at recommended doses of 200 micrograms/day, but not at higher doses that are often used.


A possible association between arterial dissection and ergotamine abuse is discussed.


This phenomenon appears to be related to bilateral simultaneous retinal ischemia delaying regeneration of visual pigments in the pigment epithelial layer.


This report describes a case of bilateral ptosis induced by chloroquine.


Dealing with drug-induced thrombocytopenia.


We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.


Various incidences of hemorrhagic complications have been cited in patients given anticoagulants after stroke or transient cerebral ischemia.


In this paper, we report a patient with primary anti-phospholipid syndrome treated by corticosteroid, who developed disseminated nocardiosis.


Pemphigus vulgaris (PV) is a rare but potentially fatal autoimmune bullous disorder which frequently affects the oral mucosa.


The incidence of primary osteogenic sarcomas of the skull is about 1 to 2% of all skull tumors.


Environmental interventions are preferred for mild symptoms; medications are the treatment of choice for severe manifestations.


Laboratory results indicated hypomagnesemia, hypocalcemia, hypokalemia, and hypophosphatemia.


A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.


Four months after cessation of treatment, a severe acne with comedones, papules, pustules, and small cystic elements broke out.


Isoniazid was stopped and patient was continued on R & E till completion of the treatment up to nine months.


The left eye healed with central corneal scarring.


INTERVENTION: Escalating dose of tissue plasminogen activator infusion.


Niacin causes a reversible toxic cystoid maculopathy that occurs in approximately 0.67% of patients taking high doses of the drug.


However, endocrine and clinical responses to chronic treatment have been less consistent.


Neurological examination revealed atrophy of small hand muscles, especially in the left dorsal interossei.


The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.


This has most commonly been a bone complication with little if any soft tissue involvement.


Here we report on a patient with severe aplastic anemia who developed PRCA after HLA-identical but major ABO-mismatched peripheral blood stem cell transplantation.


The drug was used topically, by installation and irrigation, in this case and administered orally in doses of up to 1 200 mg daily, for 6 months.


Four perfusions were performed on patients in stage III, that is those with distant metastases.


CONCLUSION: A high level of suspicion, prompt antituberculosis treatment and close follow-up are essential in management of post-transplant tuberculosis.


This report describes a patient who developed spasticity following a traumatic spinal cord injury.


The patient is alive and free of disease 4 years after the treatment of this second malignant neoplasm (SMN).


Embolism into the right leg made an embolectomy with a Fogarty catheter necessary.


Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.


Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor.


However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.


(3) In 7 of the patients who were treated with EPO before PTX, anemia was improved after PTX despite discontinuation of EPO therapy in 2, a reduced dose of EPO in 3 and the same dose of EPO in 2.


CONCLUSION: Administration of high-dose intravenous immunoglobulins can be associated with hyperviscosity syndrome manifested by central retinal vein occlusion.


Affected patients may demonstrate a pattern of self-escalation of dopaminergic medication dosing which may lead to a state of dependency.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


This case is reported to remind clinicians of the frequent presence of psychiatric symptoms in Sydenham's chorea.


Complete recovery occurred in all but two patients typically within 1-8 weeks of discontinuation of phenytoin.


Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.


Cranial magnetic resonance imaging showed widespread, abnormally high signal intensity in the deep white matter in both patients, though one patient had normal cranial computed tomographic scan.


Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.


Evans syndrome in a patient with chromosome 22q11.2 deletion syndrome: a case report.


Three patients had a complete remission, five had a partial remission, and four showed no improvements.


Misdiagnosis in all three patients led to inappropriate topical corticosteroid use.


A 70-year-old man was admitted to our hospital because of dyspnea after taking an antihistaminic agent (homochlorcyclizine hydrochloride) for itching.


These symptoms were reproduced after a second administration of brimonidine.


Opioid use in HIV patients with neurological changes.


Both the temporal association and pathologic findings suggest that the hyperbaric treatment is likely to have been responsible for the resulting complications.


RESULTS: A total of 861 patients with ischemic stroke were admitted to Calgary hospitals during the study period.


A literature review of the relationship between bulimia and affective disorder showed that the evidence from empirical research and case report studies suggests that a sizeable subgroup of bulimics suffer from bipolar disorder as well as bulimia and may benefit from antimanic medications such as lithium.


CONCLUSION: Physicians should recognise CS-treated patients as a population likely to be immune-suppressed.


Anterior uveitis and secondary glaucoma resulting from intraocular ointment has not been reported.


Repeat neuropsychological testing 7 weeks after discontinuation of the drug revealed dramatic improvement in IQ, memory, naming, and other tasks commensurate with clinical recovery in his intellectual capacity.


It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.


Adjustments in his drug regimen led to the discovery of pseudoparkinsonism and other extrapyramidal symptoms.


Toxoplasmosis retinochoroiditis after photodynamic therapy and intravitreal triamcinolone for a supposed choroidal neovascularization: a case report.


Rifampin-associated thrombocytopenia secondary to poor compliance.


Epstein-Barr virus-associated lymphoma in a child undergoing an autologous stem cell rescue.


This is the first time that the combination of PTX and vit-E has had a significant antifibrotic effect by completely reversing deep RIF as shown by CT scan normalization.


A 60-year old woman with medullary breast cancer stage IIIB underwent neoadjuvant chemotherapy with TAC (doxetaxele 100 mg/m2, doxorubicin 50 mg/m2 and cyclophosphamide 600 mg/m2).


His PSA nadir was <0.2 ng/mL and rose slowly over several months to 4.2 ng/mL, resolved, and then rose 2.3 ng/mL before again slowly resolving.


We present 2 patients with demonstrated IgE-mediated allergy to cloxacillin and tolerance to amoxicillin and cefuroxime.


In addition, dermal intravascular thrombi resolved.


Spontaneous compartment syndrome in a patient with diabetes insipidus.


Alleged medical abandonment in chronic opioid analgesic therapy: case report.


Herpes simplex following intra-articular sacroiliac corticosteroid injection.


Patients with lymphoblastic lymphoma who had treatment with L-asparaginase and steroid are predisposed to the development of cortical venous thrombosis and may have this syndrome in addition to a dural puncture headache.


Dexamethasone elevated markedly the levels of an immunoreactive mouse protein(s) which exhibited a Mr (53 kDa) and inducibility consistent with the major Cyp3a product.


PURPOSE: To describe the treatment of cytomegalovirus (CMV) retinitis with intravitreal sustain-release ganciclovir devices in a 16-year-old patient in third remission of acute lymphoblastic leukemia after stem cell transplantation.


Hypoxia is a predisposing factor for premature ductal closure and often occurs after maternal indomethacin therapy.


CONCLUSIONS: Intravenous followed by intra-arterial therapy is a promising approach to the treatment of severe acute ischemic stroke.


This case is the eleventh to report this condition.


One case of ameobic abscess of the liver and one case of amoebic dysentery are described in two patients who were prescribed corticosteroids as part of the intreatment for tuberculous pleural effusion.


The knowledge concerning VGB-associated visual dysfunction in pediatric patients, particularly in those who have been exposed to VGB in utero is limited.


A case is described, believed to be the first reported, of a newborn in whom severe hyperreninemic hypertension developed after pyeloplasty of a hydronephrotic kidney.


Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Specimens of thyroid tissue from two cases with Hashimoto's thyroiditis were immunohistochemically examined for expression of SSTR2A.


The imaging studies have shown that both hydrocephalus and leukoencephalopathy have improved significantly after ventriculoperitoneal shunt insertion.


Salicylate-induced hepatotoxicity is reviewed.


The development of methods to prevent or decrease peritoneal sclerosis will allow for greater application of this innovative therapeutic approach.


Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.


Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.


There was no relation between functional improvement and increased sexuality.


Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.


CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.


Two weeks before angioedema, the patient had started a new topical treatment with a gel containing 10% BP for acne.


A common thread is that they all make some pathophysiologic sense.


We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.


The methemoglobinemia was readily reversed with the administration of methylene blue.


Diagnosis was established by microscopic examination (Gram and Kinyoun) and culture of centrifuged dialysis fluid and the patient was treated with Trimethoprim-Sulfamethoxazole by intraperitoneal route.


Liver histology showed marked portal inflammation with lymphocytes, monocytes and eosinophils, associated with lobular inflammation (indicative of a histological pattern consistent with drug-induced hepatitis).


Corneal endothelial deposits associated with rifabutin use.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Paclitaxel is a chemotherapeutic agent with activity directed against several malignancies.


A single site of oozing was injected with epinephrine.


The regimen was based on conditioning experiments with animals who had lupuslike autoimmune disease.


Hemolytic uremic syndrome (HUS) is a rare complication following solid organ transplantation.


Therefore, angiotensin-converting enzyme (ACE) inhibitors would appear to be appropriate therapy for hypertension in such patients.


Cyproterone acetate (CPA) is a widely used drug in the treatment of advanced prostatic carcinoma.


By searching for the key words AHS, alopecia areata (AA, punctuate absence of terminal scalp hair), AA totalis (complete absence of terminal scalp hair), and AA universalis (total loss of terminal scalp and body hair) using PubMed, only 2 cases, to date, developed alopecia in the convalescent status of phenobarbital-induced AHS.


Physicians should be aware of this possible association because the signs and symptoms of Sweet's syndrome are easily mistaken as being due to infection.


Two patients with ovarian carcinoma developed acute erythroleukemia following prolonged chemotherapy with an alkylating agent.


Overall, the prevalence of patients lacking both lipodystrophy and serum lipid abnormalities was markedly higher for the cases than for the controls (69.5 vs. 13%, P<0.001).


We conclude that the currently available data do not indicate that thrombolysis contributes to a significant increase in bleeding complications when administered during CPR.


The second patient developed similar symptoms on day 3 of treatment with 2500 mg/m2.


Skin biopsy revealed multiple superficial thrombosed vessels with focal epidermal necrosis as well as prominent interstitial mucinosis.


In the third patient akathisia was sufficiently controlled by dose reduction.


Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.


Although her seizures stopped, her blood pressure fluctuated between 90/60 mm Hg and 60/30 mm Hg over the next several hours, requiring treatment with intravenous fluids and pressor therapy.


In both, metoprolol produced objective and subjective improvement of the tremor without producing bronchospasm.


Discontinuation of simvastatin and cyclosporine resulted in resolution of rhabdomyolysis and normalization of renal function.


Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.


The nystagmus resolved as the serum phenytoin level fell, as demonstrated by electronystagmography.


The manufacturer began a Pregnancy Prevention Program (PPP) in 1988; however, exposed pregnancies continue to occur.


Complications appear to result from depletion of plasma proteins involved in coagulation and fibrinolysis.


Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively.


We discuss about the hypothesis that GHD may be related to chemotherapy and we report a review of previous published cases.


IFN-alpha therapy (5 million U/day) was administered for 6 months longer.


The patient's WBC count recovered within 4 days after the change in therapy.


One of the postulated mechanisms of action is the release of endogenous opioids and/or the stimulation of opioid receptors in the central nervous system (CNS).


We report a case of carcinoma following 42 years of chronic empyema in a patient who underwent surgery for a hydatid cyst at the age of 3.


A 32-year-old male schizophrenic patient on ziprasidone treatment was admitted to the hospital following a seizure.


CASE REPORT: A 52-year-old woman presented with an extensive flare of psoriasis associated with joint pain, especially in her knees and elbows.


A symmetric elevation of diaphragms was shown on radiography and fluoroscopy.


We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.


Chemotherapy may be reserved for patients with positive cerebrospinal fluid, extracranial disease, or subsequent relapse.


To our knowledge, t(4;11)(p12;q23) has been reported in two previous patients, and MLL and FRYL rearrangement was demonstrated in one of them.


Immune reconstitution inflammatory syndrome should be considered in the differential diagnosis of unexplained vulval ulceration that arises after starting HAART.


These symptoms worsened within a few days of an increase in the dose of fluvoxamine to 50 mg twice daily.


The authors report the case of a 61-year-old man with CML treated with imatinib with a good response, and they switched to dasatinib after grade 4 hepatic toxicity.


It is the most prescribed antineoplastic drug in the world, with approximately 10 million women-use-years of experience.


Hyperthyroidism may exacerbate asthma.


These findings are consistent with a model suggesting that both platelet and megakaryocyte mass contribute to a receptor-dependent consumption process regulating the endogenous TPO level.


High dose methotrexate would appear contra-indicated in situations where massive tumour lysis is possible.


Anaphylaxis to cisplatin is an infrequent life-threatening complication which may occur even in patients who have received prior treatment with cisplatin.


Calciphylaxis in a patient with end-stage renal disease secondary to systemic lupus erythematosus associated with acral gangrene and mesenteric ischemia.


Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.


MR images revealed extensive cortical and subcortical white matter brain edema.


Recombinant human growth hormone (rhGH) therapy in Prader-Willi syndrome (PWS) causes increased basal metabolic rate and oxygen consumption, and hence increased ventilatory load.


In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.


This is the second case of progressive multifocal leukoencephalopathy in a myasthenic patient.


Its occurrence in diabetic children has not been previously reported.


The mechanism of this effect is not entirely clear, but 5-azacytidine produces hypomethylation of the gamma gene at certain sites, and gene expression and DNA hypomethylation are related phenomena in many other systems.


We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.


Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.


In an elderly patient with unresolving acute bronchospasm, herpesvirus infection of the lower respiratory tract should be considered in the differential diagnosis.


The adequacy of corticosteroid replacement therapy may best be assessed by monitoring the levels of ACTH.


Within four weeks after initiation of chemotherapy, the International Normalization Ratio (INR) increased from 3.04 to 39.56.


The patient's visual acuity was 6/20 (non-corrected) in the right eye and 6/10 (-1.75/-1.00 x 91) in the left.


CONCLUSIONS: The optimal anticoagulant for use in a patient with HIT and concurrent hepatic and renal failure is unclear.


In summary, because infected grafts can lead to serious complications, besides careful donor screening, it is important to achieve early recognition of contaminated organs by culturing the perfusate to start specific antibiotic or antifungal therapy after transplantation if necessary and avoid the rare but, in this case, fatal consequences of these infections.


Severe respiratory syncytial virus pulmonary infection in a patient treated with fludarabine for chronic lymphocytic leukemia.


Plasma cryofibrinogen was measured before and during treatment with stanozolol.


Four months later reversible camptocormia was manifested again concomitantly with about the same plasma valproate levels as above.


The patient had removed the hair from her axillae with wax 3 weeks before the development of the eruption.


Since its release in the United States market in 1996, few cases of fatal acute intoxication have been reported in the literature.


Pediatric clonidine intoxications.


Cyanoacrylate glue for type iii lad perforation.


This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide.


The management of this clinical challenge is reviewed, in the absence of a clinical guideline, with particular reference to the judicious tailoring of anti-platelet therapy, the role of therapeutic endoscopy and the utility of blood transfusion.


Successful treatment of postoperative pyoderma gangrenosum with cyclosporin.


Moreover, in the appropriate clinical setting, even in the absence of pulmonary signs or symptoms, diffuse pulmonary uptake of labeled leukocytes should alert the physician to the possibility of drug-induced pneumonitis.


Clinicians should consider early diagnostic amniocentesis in patients in preterm labor with a history of prior amniocentesis, and the routine Gram stain and culture of amniotic fluid.


White, flocculent material was observed in the anterior chamber and 24 hours later this settled on the iris surface.


Preoperative chemotherapy with carboplatin alone in high risk medulloblastoma.


Drug-induced gingival enlargement has been reported in patients treated with various types of anticonvulsant drugs, and is generally associated with the presence of plaque, gingival inflammation, and a genetic predisposition.


Although it is generally well tolerated, 30 to 45% of patients may experience adverse cardiac effects.


This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.


A case report and review of the literature.


Renal function returned to normal eventually, but she continued to have relapses of exfoliative dermatitis up to a year later.


Two years later myasthenia gravis appeared.


The patient achieving a partial response experienced no side effects while receiving ipilimumab.


Once the diagnosis was made, he was treated with adrenaline and made a full recovery.


We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).


Laboratory studies revealed a white blood cell count of 4900 mm(-3) with 67% neutrophils and 27% lymphocytes.


Abdominal CT showed diffuse swelling of the pancreas, with two distinct masses in the corpus and the tail.


Bilateral inguinal scrofuloderma during steroid therapy in a patient with bullous pemphigoid.


In some patients, clinical vigilance for antidepressant-induced dysphoria may be warranted for extended periods of time.


Malignant lymphoma of skin associated with postmastectomy lymphedema.


On the basis of the clinico-radiologic presentation, a pulmonary hemorrhage was likely to occur; so to clarify the origin of this process, a complete serologic examination was performed but all the antibodies were negative.


The most commonly reported side effects include dry mouth and dysphagia.


A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.


As a result, the Flexiflo Inverta percutaneous endoscopic gastrostomy tubes with externally removable internal bumpers were found useful in the treatment of buried bumper syndrome, and the buried bumper was easily removed by external traction without any endoscopic or surgical methods.


Methylephedrine is generally harmless and is contained in many cough and cold preparations.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


Also, concomitant therapy with antianxiety medications that may mask the symptoms of electrolyte disorders should be undertaken with caution.


Review of the literature leads us to propose the following hypotheses: (1) that considerably increased stress-induced cortisol concentrations in critically ill patients may contribute to adverse outcomes and (2) that therapeutic suppression of the persistent and substantially elevated glucocorticoid levels in selected cases may be a beneficial therapeutic option.


The patient survives with severe sequela which confirms slow progression as typical in nonAIDS cases.


DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.


Later, she began treatment with mirtazapine.


The patient did not achieve remission despite intensive chemotherapy, and subsequently underwent UCBT with a standard conditioning regimen.


Nephrotic patients in endemic areas of Strongyloides infection should have the differential white cell count checked.


We describe a 58-year-old female patient with end-stage renal disease who 7 years after the onset of dialysis presented with pain and movement restriction of various joints.


On December 5, 1995, he began therapy with recombinant IFN-alpha at a dose of 3 MIU three times a week.


Hepatotoxicity after high-dose methylprednisolone for demyelinating disease.


This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.


Once ARF is established, repair processes set in which appear to depend on growth factors such as epidermal growth factor and insulin-like growth factor 1, of which there is a relative shortage in established ARF.


We also discuss the possible role of protein S deficiency as a contributing factor.


We report a case in which ARB was given to the mother from the first trimester until 26 weeks' gestation.


A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe.


Inferior oblique paresis, mydriasis, and accommodative palsy as temporary complications of sinus surgery.


Nine children with airway obstructing hemangiomas were managed with corticosteroid therapy for durations of 6 weeks to 17 months.


Thus, measures must be taken to prevent and treat PVOD after BMT.


However, given the clinically significant result to the interaction between tolazoline and cimetidine we report, the use of cimetidine in tolazoline induced upper gastrointestinal hemorrhage should deserve more attention.


Neuroleptic malignant syndrome (NMS) is a rare, but potentially lethal complication of antipsychotic medication.


Methylprednisolone pulse therapy was very effective for the treatment of the HPS.


Comparable adverse effects, such as disorientation and temporary amnesia, have been reported in patients in the analogous agent, propranolol.


Physicians prescribing these drugs should be aware of this side effect, which, if not recognized and treated appropriately, is potentially devastating.


A complete clinical and laboratory recovery took place following withdrawal of drugs.


CONCLUSION: Cyproheptadine may be a useful adjunct to baclofen and benzodiazepines in the management of acute ITB withdrawal syndrome.


A 72-year-old patient was submitted to an elective laparoscopic cholecystectomy, and a tubular adenocarcinoma in the gallbladder was incidentally diagnosed.


In addition, preprandial subcutaneous regular insulin was switched to lispro insulin.


Aromatic antiepileptic agents, such as phenytoin, carbamazepine, and phenobarbital are the most frequent causes of this syndrome.


The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.


Several hypersensitivity reactions to cloxacillin have been reported, although IgE-mediated allergic reactions to the drug are rare and there is little information about possible tolerance to other semisynthetic penicillins or cephalosporins in patients with cloxacillin allergy.


Crosslinking for post-LASIK corneal ectasia may induce DLK.


Hemodiafiltration for vancomycin overdose in a patient with end-stage renal failure.


The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder in which a sustained release of antidiuretic hormone occurs because of certain diseases, pharmacological agents, or trauma.


RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.


CONCLUSION: The coexistence of a common prothrombotic risk factor and haemophilia may cause severe complications, in particular if the bleeding disorder has to be corrected temporarily by administration of the concerning deficient agent.


A 53-year-old woman, who had shad a VP shunt implanted 3 months previously for hydrocephalus due to intracranial hemorrhage, presented with fever off and on, drowsiness and seizure attacks for 1 week.


Early recognition of WE may be more difficult in children, because the classic triad of symptoms may not develop fully.


We present two children with acute lymphocytic leukemia who developed leukoencephalopathy following administration of a combination of intravenous ara = C and methotrexate during the consolidation phase of chemotherapy.


EEG changes were diffuse spike and wave complexes and disappeared after discontinuation of therapy.


Hemophagocytic lymphohistiocytosis in a pancreas-kidney transplant recipient: response to dexamethasone and cyclosporine.


Long-term neuroleptic therapy in chronic anorexia nervosa complicated by tardive dyskinesia.


Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation.


A potential role for renal and hepatic impairment in the observed protracted course of amiodarone-induced thyrotoxicosis is suggested.


Topical vaginal oestrogen cream used for treatment of burn injury of vaginal mucosa after misapplication of 100% acetic acid in a perimenopausal woman: a case report.


After initiation of topical vitamin D3 ointment (20 micro g/g of tacalcitol) 10 g/day for the skin lesions, both the serum level of calcium and urinary excretion of calcium increased gradually.


The syndrome may be difficult to detect because it can mimic several other entities.


Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.


Fulminant autoimmune hepatitis after successful interferon treatment in an HIV-HCV co-infected patient.


Chemoradiation therapy: effect on dental development.


It generally is characterized by fever, altered mental status, rigidity, and autonomic dysfunction.


Significance of subclinical entrapment of nerves in lead neuropathy.


The physiology and pharmacology of erection are reviewed, and pharmacologic treatment options and surgical treatments are reviewed.


A clinically atypical, neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence (1970 to 1973) with human growth hormone processed from pooled cadaveric pituitary glands.


Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.


Aluminum intoxication, along with other factors, was considered to be the cause of TC development.


Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.


Acute renal failure during lisinopril and losartan therapy for proteinuria.


MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.


A 9-month-old boy with progressive hepatosplenomegaly and neurodevelopmental delay was studied.


This case should increase awareness of the risk of invasive disease caused by penicillin-resistant Streptococcus pneumoniae in the early postoperative period after splenectomy.


However, the spectrum of hosts and clinical presentations of invasive aspergillosis are increasing, due in part to better medical treatments that prolong the survival of patients with cancer, severe infections, and organ failure.


Aggressive endometrial carcinoma in a breast cancer patient treated with tamoxifen with normal transvaginal ultrasonography.


Rapid destruction and lysis of lung nodules by chemotherapy seem to be the main mechanism of pneumothorax development.


Five percent solution of ethanolamine oleate(EO) has been used as sclerosing agent.


Two patients with non-miliary pulmonary tuberculosis developed a syndrome resembling adult respiratory distress following initiation of drug treatment.


Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer's disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids.


Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.


In addition, the development of tardive dyskinesia and its subsequent amelioration with a depot form of a high-potency neuroleptic are discussed in relation to these disorders.


Eye care professionals must take care to avoid potential misdiagnosis of Herpes simplex keratitis, avoid topical corticosteroids in contact lens wearers with an unknown keratitis, and pay special attention to the fellow eye for potential bilateral infection when Acanthamoeba has been diagnosed in one eye.


Elements in the patient's history that may be risk factors are discussed.


The first patient was a 61-year-old man with a 30-year history of fistulizing CD in whom B-cell non-Hodgkin's lymphoma was diagnosed 9 months after treatment with infliximab.


Shortly before admission to our hospital, the patient had discontinued his hydrocortisone medication.


We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.


Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.


The precise timing of each step of the surgical procedure remains difficult to codify.


Nasopharyngeal carcinoma is a rare cancer in Western society, however there is a higher incidence in Asian.


RESULTS: During the study periods, 1998 cases of endoscopic sinus surgery were identified where topical 1:1000 epinephrine was used.


Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.


We examined the in vitro inhibition of the clonogenic capacity of bone marrow hematopoietic progenitor cells of this patient by D-Pen, and found strong inhibition in burst-forming unit-erythroid and colony-forming unit-megakaryocyte assays, but not in colony-forming unit-granulocyte/macrophage assays.


We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.


Toxic shock syndrome associated with the use of the vacuum-assisted closure device.


All patients had typical radiological, magnetic resonance imaging or pathological changes of osteonecrosis involving the femoral heads, while two also had superimposed avascular necrosis involving the humeral heads.


Marrow proliferation as a cause of hearing loss in beta-thalassaemia major.


METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.


Morphea after bromocriptine therapy.


Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.


Sulfasalazine-induced hypersensitivity syndrome and hemophagocytic syndrome associated with reactivation of Epstein-Barr virus.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


Camptocormia induced by atypical antipsychotics and resolved by electroconvulsive therapy.


A model that may potentially assist in the clarification of androgen-mediated effects on mood is the study of cryptorchid men who may grow up with varying degrees of testosterone deficiency depending on the time in their life when cryptorchism is corrected.


This outbreak demonstrates the ability of drug-resistant Salmonella to spread from the animal to the human reservoir and, in a suitable host, produce a fatal infection.


Extensive immunological investigations were performed in a patient with definite seronegative rheumatoid arthritis who developed hypogammaglobulinemia in the course of gold therapy.


Perhexiline maleate is an agent currently under investigation in Canada that is used for angina unresponsive to other treatment.


It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.


At the University of California at San Diego (UCSD) Cancer Center, 115 patients with advanced intra-abdominal malignant conditions have been treated with several intraperitoneal chemotherapy programs.


A case study is included to illustrate the dangers of inappropriate naloxone use.


The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.


Full visual electrophysiology, including flash electroretinography (ERG), pattern electroretinography, multifocal ERG using the VERIS system, electro-oculography, and flash and pattern visual evoked potentials, was undertaken.


However, engraftment was not achieved.


In our study, we recorded glucose dynamics by a continuous glucose monitor system over 2 to 3 days before and during acarbose treatment, while the patient was on a well-controlled diet.


A significant inverse correlation was observed between the increase in the longitudinal diameter of the liver and the decline in albumin levels, and between the increase in the longitudinal diameter of the liver and the drop in platelet count.


CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.


We report a case of inoperable esophagogastric junction tumor with hiccupping after esophageal stent that could only be treated with baclofen.


Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.


Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy.


The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.


Recurrent, bilateral, and severe conjunctival hemorrhages mandate the search for an underlying etiology, such as a blood dyscrasia, blood clotting disorder, or recurrent increased intrathoracic pressure caused by repetitive vomiting or coughing spells.


Careful clinical and biochemical monitoring seems necessary in children with primary glomerulonephritis, other than those transplanted, after IVPMP, and factors predisposing to neurologic sequelae should be further defined.


One must be cautious in extrapolating from a case report, but these findings strongly suggest a direct effect of carbamazepine on spermatic function.


The other ten were given Adriamycin without this compression.


Reflexes, tone, and myoclonus also decreased.


The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.


Calciphylaxis in a patient with normal renal function: response to treatment with sodium thiosulfate.


Cortisol concentrations became detectable 2 days after initiation of mifepristone treatment and persisted, being detectable for a period of at least a week after cessation of the drug.


There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.


Within 6 months of pranlukast withdrawal, anemia resolved and urinary sediment and renal function normalized.


Acute erythroleukemia complicating prolonged chemotherapy for ovarian carcinoma.


We report 2 cases of patients receiving sunitinib for metastatic renal cell carcinoma while undergoing dialysis.


8. The leukemogenic potential in man of prolonged cytotoxic agents therapy, especially with alkylating agents, seems to be well established.


Six months after the onset of type 1 diabetes mellitus, the patient continues to receive 40 units of insulin daily.


The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.


She made remarkable improvement and remains transfusion independent afterwards.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


The case demonstrates that hypersensitivity reaction to pranlukast and resultant ATIN is possible, and that periodic urine testing in patients receiving pranlukast should be considered.


The recent cloning of the FMF gene on the short arm of chromosome 16p, and the subsequent finding that its tissue expression is limited to granulocytes, has helped to explain the dramatic accumulation of neutrophils at the symptomatic serosal sites; the wild-type gene likely acts as an upregulator of an anti-inflammatory molecule or as a downregulator of a pro-inflammatory molecule.


Three cases of unintentional overdose with simple analgesics are presented.


Although this patient had multiple risk factors implicated in the development of invasive pulmonary aspergillosis, the infectious potential of inhaled marijuana must be recognized.


An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.


The association of CLL and acute leukemia is a rare event described in < 1% of CLL, the type of acute leukemia being either from the lymphoid or more often from the myeloid lineage.


Awareness of this condition is important, because early recognition can prevent morbidity and lead to safe and effective treatment.


After switching, 11 got better, 29 remained stable whereas seven got worse, according to the Global Improvement.


Duodenal ulceration: a complication of tolazoline therapy.


Its mode of anti-inflammatory actions in rheumatoid arthritis is not clearly understood, but modulation of neutrophil activity or inhibition of neutrophil inflammatory product formation or release appear to play a role.


All but one patient were receiving tacrolimus monotherapy, excluding other drugs that might have been involved to cause the syndrome.


Can magnesium sulfate therapy impact lactogenesis?


The patient was successfully treated with intravenous pamidronate on his first admission and with hydrocortisone on the second.


In March 1999, a 35-year-old woman had uneventful laser in situ keratomileusis in both eyes on the same day.


The safety and tolerability profile of rFVIIa in bleeding neonates was also evaluated.


Hepatopathy subsided after the cessation of carbamazepine and lynestrenol.


Although the mechanism of this paradoxical phenomenon is not well understood, a defective local tissue immune response with gradually increasing maturity of the lesions during antituberculous therapy, which results in poor penetration of these drugs into the lesions, might be a possible explanation.


A high percentage experienced good to excellent results.


Moreover, the safety and efficacy of intracranial vertebral stenting should be further reevaluated by large-scale randomized trials.


This study provides a review of the medical literature and presents the intralesional injection technique of 0.1% bleomycin into the wart tissue itself.


Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.


Although the movement disorder could not with certainty be attributed to trazodone alone, the drug at least acted as an eliciting agent.


Benefit from this was limited and a course of intra-arterial urokinase was instituted.


The prevention and treatment of de novo HBV infection after OLT is discussed.


We describe an exceptional case of Candida tropicalis sepsis in a patient submitted to allogeneic BMT; the diagnosis was made on a peripheral blood smear, when the pt was neutropenic and only mildly febrile.


After 12 months of treatment, molecular biology showed an important reduction in the peripheral blood of the fusion oncoprotein bcr-abl p210-b3a2.


PURPOSE: Small-cell esophageal carcinoma (SCEC) is a rare disease for which standard therapy has not yet been established.


She has been admitted with non-productive cough, dyspnoea and fever 11 months after the initiation of combination therapy.


In 1996, the manufacturer began a direct-to-consumer advertising campaign, raising concerns of more exposed pregnancies.


Histological studies confirmed the diagnosis of KS and documented its complete regression.


Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.


Although high-dose methotrexate has been shown to be useful in the treatment of primary osteogenic sarcoma, the tumoricidal effects of therapy appear to have caused a fatal rise in intracranial pressure.


Improvement in prothrombin time, activated partial thromboplastin time, and fibrinogen after rFVIIa administration was statistically significant, as compared with that observed after conventional treatment.


We suspect that isotretinoin may complete for normal retinol binding sites on cell surfaces or transport molecules.


She experienced cardiac arrest and died 72 hours after receiving chemotherapy.


Extrahepatic cholestasis, viral hepatitis and autoimmune liver disorders were excluded.


The results of these studies could also lead to significant modifications in recommendations for long-term maintenance therapy with cytotoxic agents.


We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.


Many new serotonergic antidepressants have been introduced over the past decade.


This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.


PTLD appears to be different in its pathogenesis from that of PCNSL which occurs anew in the brain of these patients.


Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.


Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.


Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma.


An intensive search revealed that this patient was receiving coumadin that was given by the mother.


She was treated with fluid resuscitation, wound dressing, and antibiotics.


Inhibition of cytochrome P450 seems to be an important mechanism.


Ampicillin trihydrate aggravated the symptoms of two myasthenic patients.


Calcium-channel blockers are useful for the treatment of hypertrophic cardiomyopathy (HCM), but, their adverse effects, especially, those of diltiazem, have not been of much concern.


Best-corrected visual acuity was 20/50 O.D. and 20/60 O.S.


At surgery, the diagnosis of focal nodular hyperplasia was established.


We describe four patients with episodic bilateral vision impairment related exclusively to light exposure.


However, two previous descriptions of interstitial nephritis related to treatment with TKIs, combined with this current report suggest that TKI therapy could be associated with this rare but life-threatening complication.


Two patients developed acute cholangitis and 2 patients experienced skin phototoxicity.


CONCLUSIONS: RPE tear is a complication that may occur following PDT in particular when the PDT is applied to an occult subfoveal CNV.


Atypical necrotizing scleritis after strabismus surgery.


She also had low-grade fever, intermittent chronic abdominal pain, weight loss, polyarthralgia, and conjunctivitis.


The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance.


Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.


We used telmisartan to manage high blood pressure values in an HIV-positive patient with insulin-dependent diabetes.


PURPOSE: To investigate the concentration-side effect relationship in a patient with severe acyclovir-induced neurotoxicity and to summarize the information available in the literature about central nervous system side effects due to acyclovir.


Photosensitisation induced by clofazimine in a cat.


However, the occurrence and management of akathisia induced by fluvoxamine have not been described.


Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.


We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.


The temporal sequence suggests that the drug infusion initiated the lung injury.


Clinical suspicion of ASPPC upon observation of these characteristic features is crucial for early diagnosis and treatment.


Besides hysterectomy, the treatment options for adenomyosis have been limited.


Treatment with high-dose intravenous IgG (HDIgG; a first-generation preparation) was ineffective, but a course of steroids resulted in a rapid increase in the the platelet count.


Laparascopy proved useful in making the initial diagnosis, but may have contributed to the pathogenesis of the pulmonary process.


Potential mechanisms involved in the occurrence of ischemic colitis in patients receiving tegaserod are also discussed.


She refused surgery to remove the eye and orbital contents (exenteration), and was referred to palliative care.


When clonazepam was reduced and discontinued, these behaviors significantly decreased from 3.1% of intervals (95% confidence band = 1.6% to 4.6%) to 0.1% of intervals (95% confidence band = 0% to 0.1%).


Practical aspects of 3,4-diaminopyridine treatment of the Lambert-Eaton myasthenic syndrome.


A pulmonary restrictive defect with a prominent decline of forced vital capacity (FVC) when the patient was on supine position was recorded.


Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.


Prolongation of the prothrombin time owing to a transient reduction in factor VII activity is described in a 14-month-old child with organophosphate poisoning.


Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.


All patients developed esophageal varices, 5 patients presented at least one bleeding episode and 2 required TIPS.


OBJECTIVE: To describe a newly recognized adverse effect of imiquimod.


Because treatment has focused mainly on supportive care and generally unsuccessful immunosuppression, children with BO experience significant morbidity and mortality.


Exacerbated radiodermatitis and bilateral subdural hemorrhage after whole brain irradiation combined with epidermal growth factor receptor tyrosine kinase inhibitors for brain metastases in lung cancer.


Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both.


Transthoracic echocardiogram showed global hypokinesis with an ejection fraction (EF) of 5-10% prior to cardiac arrest, compared to baseline and following EF's of approximately 35%.


Treatment of periodontal disease in a patient with Turner's syndrome.


Systemic and topical antibiotics were administered and urgent surgical debridement and replacement of the LASIK flap was performed.


Five personal observations of an acute amnestic episode in younger individuals after intake of clioquinol are described together with three observations from the medical literature.


Toxic epidermal necrolysis associated with interleukin-2.


Massive subfascial hematoma after alteplase therapy for acute myocardial infarction.