It is postulated that renal tubular damage secondary to the cumulative effects of repeated courses of aminoglycosides resulted in hypomagnesaemia, and we suggest screening for this problem by monitoring serum magnesium regularly in all patients with CF receiving multiple courses of aminoglycosides.


Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.


The pharmacokinetic parameters for ifosfamide using model-independent methods were calculated: Vd = 0.23 l/kg, t1/2 = 4.8 h, and ClT = 3.30 l/h per m2.


He received blood transfusion and recombinant human granulocyte colong-stimulating factor (filgrastim).


Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful.


RESULTS: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.


Fifteen patients with active disease and three whose disease was inactive received increased doses of corticosteroids, and four active cases and one inactive one stayed on the same doses.


The successful outcome of the present cases suggests that the timely addition of levothyroxine treatment alone or in combination with steroids is useful and effective in the management of hypothyroid Graves' ophthalmopathy.


Neurotoxicity of intrathecal methotrexate: MR imaging findings.


Extensive hormonal evaluation was performed in a girl with adrenal carcinoma during the primary tumor stage, following adrenalectomy, during the period when metastases were evident and while on treatment with o,p'-DDD.


Treatment with continuous intravenous naloxone infusion, lumbar catheter drainage of cerebrospinal fluid, and control of hypertension and status epilepticus resulted in an excellent outcome with return to neurological baseline.


A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.


This case report examines the possible causative factors in the development of post-surgical herpes zoster.


INTRODUCTION: Anterior ischemic optic neuropathy (AION) describes a defect of the optic nerve leading to irreversible loss of vision in most cases.


To our knowledge, this is the first case of stroke occurring in a pregnant woman following vasopressor therapy for spinal anesthesia-induced hypotension.


A 15-year-old boy with previously normal thyroid function is described who developed hypothyroid goiter within six weeks following bipedal lymphography.


Nevertheless, symptomatic CH has been reported in association with various underlying diseases.


Reflex sympathetic dystrophy syndrome (RSDS), which probably has a multifactorial etiology, may appear after kidney transplantation.


Patients were vaccinated with BCG (Moreau strain) between 17 days and 4 months of age.


Little information is available concerning the occurrence and outcome of this syndrome after administration of more recent chemotherapeutic agents.


Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case.


INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).


The risk of developing sAML is estimated to be between 1% and 5%, 2-20 years after exposure to etoposide but may also be related to cumulative drug doses, treatment schedules, host factors and co-administration of other antineoplastic agents.


It is concluded that EBV-LPD should be included in the differential diagnosis in patients in whom lymphadenopathy develops after autologous stem cell rescue.


A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.


Somatostatin analogues are potent inhibitors of growth hormone (GH) and glucagon secretion.


Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.


We report a case of graft versus host disease after liver transplantation in which the diagnosis was made by short tandem repeat analysis.


46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.


Rosiglitazone was immediately discontinued and 11 days later the man's weight stabilized to 79 kg and remained between 79 and 80 kg 2 and 3 months after discharge.


Monitoring and predicting ototoxic damage using distortion-product otoacoustic emissions: pediatric case study.


DISCUSSION: The patient was given chloroquine by his captain in a dosage regimen appropriate for quinine (2 tablets 3 times daily for 7 d).


Effective treatment of coprophagia in a patient with schizophrenia with the novel atypical antipsychotic drug perospirone.


Nineteen children with rheumatic diseases refractory to standard treatment were given repeated large "pulses" of corticosteroid therapy.


However, there is no literature that describes the complications that occur at the time of removal of these lines.


Putaminal infarct in methanol intoxication: case report and role of brain imaging studies.


Virological tests showed significant increases of antibody titers against mumps virus and parainfluenza virus type 2, which strongly suggested that paramyxovirus infection occurred during the clinical course of DIHS.


It is important to accurately identify these infections, and polymerase chain reaction assay using universal fungal primers offers a rapid and precise diagnostic approach.


A further two cases of ocular hypertension secondary to topical facial steroids are also described.


A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.


Minoxidil was found to be highly effective, free from commonly encountered side effects and capable of achieving excellent control of blood pressure when given once daily.


His clinical course was uncomplicated until postoperative day 10, when he became hemodynamically compromised despite inotropic therapy (BP 88/53 mm Hg, mean HR 80 beats/min) secondary to stage IIIa rejection.


To our knowledge, their occurrence in the same patient has not hitherto been described.


A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.


FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature.


This behavior consisted of an apparent infatuation with a ward nurse, which ceased after medication was discontinued.


It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.


In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.


Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands, and most commonly seen in patients undergoing chemotherapy for treatment of a malignancy.


Olanzapine-associated neuroleptic malignant syndrome.


OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.


On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.


Forty-two hospitalized patients with HI disease had computerized ECG during the same 6-month period.


On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.


Antitumour necrosis factor alpha (TNFalpha) antibodies have recently been used in order to treat Crohn's disease, but their effect on cholestasis in humans has not been previously described.


We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Cytomegalovirus ventriculoencephalitis after unrelated double cord blood stem cell transplantation with an alemtuzumab-containing preparative regimen for Philadelphia-positive acute lymphoblastic leukemia.


A mutation in the neuraminidase active site (152 Arg-->Lys) led to a 1000-fold reduction in the enzyme sensitivity to zanamivir.


Thirteen consecutive stage II breast cancer patients were treated with long-term adjuvant chemotherapy using chlorambucil.


OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.


Polyvinylpyrrolidone-iodine (PI) is a widely used antiseptic agent, safe and effective, in the treatment and prophylaxis of wound sepsis.


Within a week after surgery, the patient developed septic shock secondary to multidrug-resistant Escherichia coli bacteremia and died.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Skin prick testing several weeks later identified diamorphine as the likely causative agent, a drug overlooked initially as a potential cause.


In 1997 he began calcium supplementation and a high-calcium diet; his blood pressure declined markedly, allowing him to taper off of two of his four antihypertensive medications.


Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.


In our cases, haematological side-effects were satisfactorily controlled by dose reduction without allowing the reemergence of psychiatric symptoms.


At autopsy, a disseminated fungal infection was found.


Reactivation histoplasmosis after treatment with anti-tumor necrosis factor alpha in a patient from a nonendemic area.


Rinsing of the CSF after intensive antimicrobial treatment resulted in a cure.


She had been on a combined treatment of steroid and lobenzarit disodium for the first 3 years, and then continued with a combined treatment of steroid and bucillamine for the following years until she was found to have pulmonary tuberculosis, at which time the steroid was suspended 10 months before she visited the authors' clinic.


The aerosol administration allows high concentrations of tobramycin to be delivered to the site of infection with limited systemic absorption.


Patients at increased risk were those with severe disease and taking concomitant MTX and corticosteroids.


High-dose cytarabine (HDARAC) therapy is an effective regimen in treating refractory leukemias.


The association of central diabetes insipidus (CDI) with lithium use is rare.


A 24- to 48-h course of large-dose glucocorticoid therapy is often used in the acute management of spinal cord injury.


Nonsurgical diseases such as acute colitis or enteritis can appear similar to such true surgical emergencies as abscess, perforation, or mesenteric ischemia.


A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.


All patients smoked herbal cannabis for therapeutic reasons (median duration of use six years, range two weeks to 37 years).


Gingival hemorrhage is recognized as a symptom of MDS, a rare group of potentially fatal hematological disorders, but it has not previously been documented as a presenting sign.


Seizures associated with fluoxetine therapy.


All the patients in this case series had undergone tooth extraction for recurrent dental abscesses while taking bisphosphonates.


The use of such chemotherapy regimens in Ewing's tumours should be carefully considered, particularly when radiotherapy encompassing the spinal cord is an essential component of management.


Despite progress to apparently complete remission, all manifested pulmonary nodules on computed tomography during or at the end of treatment.


The thrill of reckless driving in patients with Parkinson's disease: an additional behavioural phenomenon in dopamine dysregulation syndrome?


We have cared for three children in whom four episodes of dystonia proceeding to opisthotonus occurred in association with carbamazepine use.


Reduced TH-1 cytokine release in an adult patient with chronic relapsing Mycobacterium malmoense infection.


An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.


Both patients responded to intravenous meropenem and subsequently had uneventful marrow engraftment.


The patients treated at our institution have experienced significant side effects.


A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.


Here we report on a patient with occult HBV infection, who developed HBV exacerbation after chemotherapy for diffuse large B-cell lymphoma.


This suggests that monitoring of this drug in children with acute lymphoblastic leukemia may be helpful.


On the basis of this experience, the authors point out that in the course of acute respiratory failure in leukemic children, the combination of a negative chest X-ray and a positive pulmonary perfusional scintigraphy (compared whenever possible with ventilatory scintigraphy) in the presence of a negative CT scan could be a reliable diagnostic tool for PTE.


A single course of cladribine has been used commonly over the past decade to treat hairy cell leukaemia, with an impressive rate of complete remission and few serious adverse effects.


Bilateral vocal cord paralysis was seen on laryngoscopy.


Physicians should be cognizant of this potential complication in patients receiving thalidomide or thalidomide-like drugs who present with fever and pulmonary infiltrates and fail to improve despite treatment with broad-spectrum antibiotics.


The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.


A case of fluoxetine induced seizures, in a person with Down syndrome, is described.


Sympathetically mediated chest pain is a rare presentation, as it is similar to that of secondary hyperalgesia in the intact skin surrounding an injury site.


CONCLUSION: When performing posterior cervical decompression, surgeons must be aware of the potential for loss of normal lordosis and anterior displacement of paraspinal muscles against the spinal cord, especially in muscular patients.


Cultures demonstrated Aspergillus fumigatus sensitive to voriconazole.


Based on a Naranjo score of 7, this episode was probably related to an interaction between acenocoumarol and econazole.


Although a single case, this report questions the safety of using an intraoperative application of mitomycin C for preventing a recurrence of pterygium.


OBJECTIVE: To report the use of oral terbutaline for chronotropic support in a patient who had undergone heart transplantation.


The remaining 12 received three or more courses of treatment, and three of these patients achieved a complete response.


It may represent a uveitic immune phenomenon.


Syndrome of inappropriate antidiuretic hormone associated with vinorelbine therapy.


CASE REPORTS: We report 3 patients with chronic schizophrenia who had previously stopped clozapine due to hematologic side effects.


Clinicians should be aware of this potential life-threatening adverse reaction and monitor kidney function while patients are using linezolid.


Daptomycin for eradication of a systemic infection with a methicillin-resistant-Staphylococcus aureus in a biventricular assist device recipient.


A possible mechanism for this alarming outcome is discussed, and it is suggested that resuscitation facilities should be quickly available during such trials.


Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.


Plasmapheresis was discontinued, and intravenous ganciclovir was initiated.


Ezetimibe-induced acute pancreatitis.


The authors describe a case of the catatonia syndrome associated with disulfiram therapy.


The patient recovered and the vagina mucosa healed within two weeks.


A case report and review of the literature.


Three of the patients had received no prior alkylating agents.


Prednimustine is an ester of chlorambucil and prednisone.


Severe leukopenia associated with mild hepatotoxicity in an HIV carrier treated with nevirapine.


Recently, a number of prospective, randomized, double-blind trials have shown their success in the management of rheumatoid arthritis, with dapsone being superior to placebo and comparable to chloroquine and hydroxychloroquine.


The acronym SILENT (Syndrome of Irreversible Lithium-Effectuated Neurotoxicity) has been coined recently to denote these sequelae.


This case suggests the importance of careful observation for extramedullary relapse in patients who are treated with ATRA.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


Despite aggressive intensive care management, the patient died 17 days from the onset of symptoms due to multiple organ failure.


The tympanic membrane perforation would be treated with antibiotic/steroid drops.


We hypothesize that early glutamine supplemented tube feedings in children receiving intensive chemotherapy alone or in combination with bone marrow transplantation will result in improved nutrition with fewer infections and lower cost than TPN-supplemented patients.


The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.


On colonoscopy, inflammatory lesions highly compatible with CD were found endoscopically and histologically in all patients.


Eight to eleven months after starting treatment, TSHRAb positivity and intense scintigraphic uptake confirmed the appearance of Graves' disease.


Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.


We report a series of three patients with HCC and platelet count < 60,000/mm(3) who were successfully treated with sorafenib with no complications.


These HRCT findings were atypical compared with those of former bronchiolitis obliterans (BO) after bone marrow transplant (BMT).


All were over 45 years of age, and premorbid kidney abnormalities may have enhanced susceptibility to toxic effects of the drug.


In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.


This case report emphasizes the importance of routine vitamin D supplementation in all patients on long term cholestyramine therapy, and indicates that even in patients with small intestinal disease or resection, oral preparations of vitamin D or its metabolities and analogues may be effective.


This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.


Pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) and granulocyte colony-stimulating factor (G-CSF) promote haematopoietic progenitor cell maturation.


Clofibrate-induced myopathy in patients with diabetes insipidus.


A 4 year old boy with acute lymphoblastic leukaemia developed a pure red cell aplasia 13 months after entering remission and while on maintenance chemotherapy.


The successful treatment of autoimmune hepatitis with 6-mercaptopurine after failure with azathioprine.


The optimal treatment of IVC thrombosis has not been established to date.


Development of bilateral herpes zoster following thoracoscopic splanchnicectomy.


The cases are important in documenting that drug-induced dystonias do occur in patients with dementia, that risperidone appears to have contributed to dystonia among elderly patients, and that the categorization of dystonic reactions needs further clarification.


Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.


BACKGROUND: Electroporation is a process that causes a transient increase in the permeability of cell membranes.


Deaths occurring during clinical studies of topical minoxidil.


Methimazole-induced aplastic anemia in third exposure: successful treatment with recombinant human granulocyte colony-stimulating factor.


The neurological symptoms and signs were headaches, right quadrant hemianopia, dyslexia without agraphia, motor aphasia, numbness in and weakness of the right upper extremity, papilloedema and coma.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease.


Systemic and local factors influence growth of Candida in the stomach.


Two days after the drug was discontinued, the duration of the QRS complex was normalized.


BACKGROUND: Intravenous alteplase for acute ischemic stroke is least efficacious for patients with proximal large-artery occlusions and clinically severe strokes.


Histologic evaluation was also performed before treatment and in selected patients during treatment.


A case report revealing two previously unreported adverse side effects of meprobamate and tridihexethyl chloride (Milpath) drug therapy for a spastic colon is presented.


Delusional disorder, somatic type treated with aripiprazole--mirtazapine combination.


Several cases have been described in the United Kingdom and recently in the United States.


Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol.


The disorders were characterized by hyperandrogenism and polycystic ovaries in all cases, and were associated with weight gain and menstrual disorders in 2 of the 3 women.


Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.


Several hypotheses are advanced to explain the failure of bone erosions to heal.


A patient with a large hydatid cyst of the left lobe of the liver developed metabolic acidosis following rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent.


Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.


The authors suggest that in patients with corneal ulcers refractory to conventional treatment who are receiving colchicine, cessation of colchicine therapy should be considered.


Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.


According to the Naranjo et al. adverse-reaction probability scale, enoxaparin was the probable cause of hepatotoxicity in this patient.


The patient then developed profound bradycardia that progressed to ventricular fibrillation and asystole.


Response to rhEPO was not significantly related to age, gender, type of MDS, time since diagnosis, time since initiation of transfusion therapy, or baseline serum EPO.


Somatostatin analogues are safe and generally well tolerated.


The reactivity of these antibodies, the regulation of the rodent antigens and the identity of the human autoantigen have been investigated.


DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.


Ritonavir acted as a CYP3A4 inhibitor, diminishing carbamazepine metabolism and provoking an increase in serum levels and clinical toxicity.


CONCLUSION: A scleral abscess should be suspected in a patient with endophthalmitis or microbial keratitis or both after a scleral-tunnel incision for cataract surgery.


Accordingly, careful monitoring of liver function parameters should be performed both during and after treatment when onychomycosis requires prolonged itraconazole administration, even in asymptomatic patients lacking apparent risk factors of hepatic injury.


This species is susceptible to many antibiotics in vitro and clinically.


However, one patient exhibited no effect of PSL and died from acute oliguric renal failure in spite of aggressive measures including hemodialysis.


Candida shunt infection appears to occur by either contamination at the time of shunt placement or by hematogenous dissemination.


There is not enough evidence to prove the involvement of either olanzapine or hydrochlorothiazide or the interaction between them in this patient's myelodysplasia.


Treatment modalities have been unsuccessful and the majority of patients reported have died.


We propose that drug-induced ocular pemphigoid represents a spectrum of diseases ranging from a self-limiting, toxic form to a progressive, immunologic form.


None of the patients has clinical or radiologic findings suggestive of central pontine myelinolysis or akinetic mutism.


Renal biopsy demonstrated changes classic for acute allergic tubulointerstitial nephritis (ATIN), with mixed interstitial inflammatory infiltrate including eosinophils.


Thirty days after the 2nd booster dose, several pruritic, polygonal, purple, papules appeared on the volar aspect of the patient's wrists.


After left salpingo-oophorectomy had been performed, the patient chose to terminate the pregnancy before the initiation of combination chemotherapy with bleomycin, etoposide, and cisplatin.


The contribution of aging, hypothyroidism and stroke to the etiology of this woman's disorder is discussed.


We describe this syndrome, which occurred in one of our patients and was successfully treated by the administration of dexamethasone.


The electrocardiogram (ECG), which was read as normal prior to ritodrine infusion, demonstrated a type I second-degree AV block which disappeared upon discontinuation of ritodrine therapy.


With the increasing use of immunosuppressive agents, including TNF alpha inhibitors, it is likely that there will be an increase in the number of mycobacterial infections complicating arthroplasties.


We describe a patient who experienced a lichenoid eruption after the initiation of salsalate for relief of arthritic pain.


Three other patients with clinically determined ULD showed a variable response and some notable side effects during treatment with NAC.


This report encourages the institution of HAART once the liver graft regains normal function.


We believe that this represents an unusual case of moderate-dose MTX-induced neurotoxicity in a patient with gastric cancer, which has not previously been reported.


Only 2 of them developed P. aeruginosa septicemia and the prognosis was relatively good (7.5% mortality rate).


The patient rejected surgical procedures.


Even in typical cases PPG is often misdiagnosed and therefore wrongly treated; the unknown aetiology makes treatment difficult.


Indirect immunofluorescence demonstrated dermal binding IgA antibodies, and Western blotting of serum showed reactivity with a 250 kDa dermal antigen corresponding to collagen VII of anchoring fibrils.


One patient died suddenly during an exchange with FFP; the cause of death appeared related to microemboli of unknown nature found in the lungs at autopsy.


Diffuse, reversible arterial irregularities consistent with vasospasm were present on MRA during the acute illness.


Akathisia should be considered in all cases of apparent nonresponse to atypical antipsychotics.


This report demonstrates that PET scintigraphy might be a helpful tool in the early diagnosis of drug-induced pulmonary toxicity.


Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.


A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.


A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity.


Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.


Both tacrolimus and nefazodone are metabolized by the cytochrome P450 (CYP) 3A4 system.


Dapsone, a synthetic sulfone with chemical similarities to sulfapyridine, has been used for a number of years to treat leprosy and dermatitis herpetiformis.


Statin-associated myasthenia gravis: report of 4 cases and review of the literature.


Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.


OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.


The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.


Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.


She had been treated with AZ, 500 mg per every day for eleven days for the treatment of glaucoma.


The patient was treated with surgery and combined cytotoxic chemotherapy.


BACKGROUND: Radiation recall pneumonitis describes a very rare reaction in a previously irradiated area of pulmonary tissue after application of pharmacological agents.


It is harder to evaluate the benefit of a new technology in the face of noncomparable previous technologies.


With serious cases, however, conventional treatment may not allow sufficient time at depth for the complete resolution of manifestations because of the need to avoid pulmonary oxygen toxicity which is associated with a prolonged period of breathing compressed air.


He is well at 9 months follow-up.


METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


No systemic antibiotics would be given.


The PSG reports of four other adult groups were also reviewed: periodic limb movement (PLM) disorder (n = 28); sleep terror/sleepwalking (ST/SW) (n = 54); rapid eye movement (REM) sleep behavior disorder (RBD) (n = 70); patients with clinically unremarkable sleep during two consecutive PSG studies (n = 30).


The liver biopsy showed extensive ground-glass hepatocytes and thin septum-like fibrosis that formed portal-to-portal linkage.


We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.


CASE: We present here the case of a patient with protein S deficiency, who has used COCs together with anticoagulatory therapy (Phenprocoumon) after suffering from deep venous thromboses for 4 years.


Jaundice was the presenting symptom in all three.


CONCLUSIONS: Bosentan may significantly decrease the anticoagulant properties of warfarin.


Ziprasidone is an atypical antipsychotic drug that is believed to have a low propensity for inducing extrapyramidal symptoms, including tardive dyskinesia (TD).


Of those 18 patients who completed a full course of therapy, seven (39%) experienced a relapse; five of these were cured of their infection with a second course of antimicrobial therapy, which usually included higher doses of intravenous penicillin.


Theophylline intoxication following viloxazine induced decrease in clearance.


Pre-diabetic immune markers were repeatedly negative, and no diabetes has developed after four years of follow-up.


In clinical practice, serum level monitoring of anticonvulsant drugs is usually adequate.


Many surgeons are reluctant to use these devices because of the costs and the potential risks of inserting metallic or plastic elements into a septic joint.


Despite the patient's abnormal baseline kidney function, the very high doses of lifoAmB were well tolerated and did not result in additional renal toxicity.


The evolution is fairly stereotypical and is marked by a regression of the lesions following a dose reduction or curtailment of interferon.


Herein we report a severe adverse reaction to adalimumab in a 25-year-old female patient.


However, in some patients, pericardial inflammation resolves without progressing to chronic constrictive pericarditis.


Thus, the effect of antidiabetic agents on cardiovascular health and safety must be considered when selecting the most appropriate therapy.


At time of writing, there was no evidence of any increase in CK, myoglobin, or other markers of rhabdomyolysis.


Exacerbations of the heart failure were temporally related to the administration of the antitumor antibiotics actinomycin-D (NSC-3053) and mithramycin (NSC-24559).


Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.


BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) is characterized by a severe multiorgan hypersensitivity reaction that usually appears after prolonged exposure to certain drugs and may be related to reactivation of herpes viruses.


Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.


The case reports are followed by a brief review of the literature on differential diagnoses, risk factors, early signs and treatment data.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.


Over a 36-hour period, insulin was progressively decreased and finally stopped because of the rapid fall and normalization of blood glucose concentration.


We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.


The case is reported of a 45-year-old woman who was being treated for chronic back and right leg pain with intrathecal morphine administered via a subcutaneous continuous-infusion device.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.


We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.


A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.


The effect of the methylprednisolone (MP) pulse therapy on renal function was examined in 15 patients with renal or collagen disease.


We describe two patients with profound hypothalamic-pituitary-adrenal axis suppression resulting from the unregulated use of super potent topical corticosteroids.


Development of Peyronie's disease during long-term colchicine treatment.


Hepatic infarction caused by an embolus from an atherosclerotic lesion--a case report.


We report a patient with psoriasis and HCL who was treated for 1 week with continuous intravenous infusion of 2-CdA for recurring HCL.


2. Prior to the advent of chemotherapy, this complication was not observed in large series of patients with lymphoproliferative disorders and multiple myeloma.


Early diagnosis and medical treatment alone can result in resolution of corneal infiltrates due to acanthamoebae.


There were no other neurological abnormalities and more particularly, no seizures or myocloni were observed.


After 14 days of therapy, he was taken to the emergency department with a 3-day history of fever, headache, and neck pain.


We describe a 64-year-old man with diabetes, chronic kidney disease, and anemia who was treated consecutively with epoetin alfa and darbepoetin alfa and experienced a temporal reduction in A1C level to a nadir of 4.4%.


A patient in our hospital had ventriculitis caused by coagulase-negative staphylococci, and under neuroendoscopy we obtained clear findings of granular ependymitis.


OBJECTIVES: The primary aim of this article is to critically review the clinical features and comorbidities, epidemiology, pathophysiology, and treatment of impulse control disorder (ICD) associated with Parkinson disease (PD).


She was uncommunicative and unable to follow commands.


The treatment improved the childrens' clinical condition prior to surgery and facilitated tumor removal, resulting in partial regression of the tumor.


Tissue distribution of olanzapine in a postmortem case.


After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).


A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.


All cases presented within the first 10 postoperative days and improved with 1 month of cessation of cyclosporin (CyA), although halting, monotonous speech was evident to some degree in all five for up to 1 year.


We describe herein the first two cases of Plesiomonas shigelloides continuous ambulatory peritoneal dialysis-related peritonitis.


A case report.


Long-term prophylaxis with TMP/SMX is necessary to prevent the relapse of nocardia.


Suddenly, the infant presented inconsolable crying, and then she appeared pale, hypothermic, and irritable.


Guidelines for the safe use of hexoprenaline in preterm labour are suggested.


The immediate and short-term TKI side effects are well known, but the long-term side effects have not yet been clearly identified.


In ten cases (4.3%), radiology showed damage to the alveolar interstitium typical of inflammatory forms, whereas in the remaining three (1.3%) it depicted nodular opacities, which required differentiation between lung metastases and septic emboli.


John's wort, in addition to several prescription medications.


Severe histological osteomalacia developed in a woman with Crohn's disease 2 years after ileal resection and the start of cholestyramine therapy.


Sustained hypothyroidism induced by recombinant alpha interferon in patients with chronic hepatitis C.


Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism.


Median platelet nadir counts for all patients was 14.5 x 10(9))/L (range 1-24).


The thrombolytic therapy, together with heparin prophylaxis, was successfully administered in the hematology ward without the need for intensive care support (i.e. mechanical ventilation).


Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.


METHODS AND RESULTS: Skin prick tests were positive to cloxacillin in case 1 and negative in case 2.


A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.


The nature of the process was not recognized initially, and the patient was treated with intravenous antibiotics.


The clinical, biochemical, and pathological picture was similar to Reye's syndrome.


We report a case of biopsy-proven BO after bone marrow transplantation in a child who, after failed corticosteroid therapy, was treated with infliximab, a monoclonal antibody with binding specificity for human tumor necrosis factor-alpha.


A 65-year-old female patient presented with jaundice followed 2 days later by severe dyspnea and tachypnea which worsened when patient was lying flat, 1 week after the fourth dose of adalimumab.


Failure to thrive is also a frequent side effect of treatment.


Other cases have been reported in the literature, in one of which assisted ventilation was required.


He had a permanent pacemaker inserted 4 years previously for Mobitz type II AV block detected on stress electrocardiogram, which developed 1 month after initiation of lopinavir/ritonavir.


However, cyclosporine dependency is associated with the risk of nephrotoxicity.


Pathognomonic signs of CIN were present.


CONCLUSION: Our data suggest an association between cGVHD and post-HSCT MN.


A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.


DESIGN: Retrospective case review.


Alertness returned over the 24 hr following by the discontinuation of BH-AC and intravenous administration of diphenylhydantoin, although she complained of intermittent headaches and visual disturbance.


Repeated relapse occurred despite a variety of treatments until the institution of high-dose neuroleptic therapy.


Of note, change from tacrolimus to cyclosporine together with dexamethasone produced rapid response with status improvement.


The present case report depicts the management of a patient with persistent idiopathic facial pain following the placement of 2 dental implants in the mandibular anterior alveolar ridge.


SETTING: The Spinal Rehabilitation Department, Loewenstein Hospital, Raanana, Israel.


RESULTS: All cases developed corneal endothelial deposits after previous use of rifabutin.


Although corticosteroids are frequently used to prevent vomiting induced by chemotherapeutic agent, their mental effects have received little attention in oncology settings.


Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.


Early ritonavir-induced maculopapular eruption.


DISCUSSION: Fifty percent of VPA is metabolized by glucuronidation, 40% undergoes mitochondrial beta-oxidation, and less than 10% is eliminated by the cytochrome P450 isoenzymes.


Dumping syndrome is a sequel of gastric surgery in adults and Nissen fundoplication in children.


We suggest the use of esmolol for treatment of dysrhythmias secondary to caffeine toxicity; to the best of our knowledge, the use of esmolol has not been reported for this purpose.


A case of noncardiogenic pulmonary edema by ethanolamine oleate.


Neutropenia due to parvovirus B19 infections in patients with paroxysmal nocturnal hemoglobinuria.


This is probably due to the presence of a common ingredient, styrax gum.


A diagnosis of trastuzumab-induced pneumonitis was made.


Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast.


All 4 patients developed steroid-induced glaucoma and failed traditional immunosuppressant therapy.


DISCUSSION: Capecitabine is not intrinsically cytotoxic, but is converted to fluorouracil in tumor tissues via a 3-step enzymatic pathway.


PTX (800 mg d-1) and vit-E (1000 U d-1), orally administered daily for 18 months, were well tolerated.


PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.


The case report of a patient with metastatic osteogenic sarcoma of the right ventricle who had had an interscapulothoracic amputation in October, 1970, and a left lower lobectomy in June, 1973, for pulmonary metastasis is presented.


OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine.


Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): A case report.


A colonoscopic examination revealed a sigmoid colonic ulcer and stenosis; the patient was treated conservatively.


Although the elimination of normeperidine is decreased as well in these patients, the ratio of normeperidine to meperidine is generally low, and the narcotic effects of meperidine usually predominate.


Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.


Medical and ophthalmic management is discussed in a case of subconjunctival and external hemorrhage from the eye secondary to prolonged prothrombin time in oral anticoagulation therapy.


At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.


The standard of care for treating schizophrenia is to first use monotherapy of adequate dosage and duration, including a trial of clozapine before adding a second agent.


Visual acuity recovered almost completely or completely (mental debilitation in one patient made accurate assessment uncertain).


The crystalline lens was clear.


Although dipyridamole perfusion imaging has a good safety record, serious side-effects may rarely occur.


He developed rhabdomyolysis with hemoglobinuria after 2 weeks of treatment.


With increasing administration of acetylcholinesterase inhibitors for patients with Alzheimer's disease, practitioners should be aware of the potential for drug-drug interactions and other complications.


Based on the history and clinical features, a diagnosis of insulin-induced lipohypertrophy was made.


Childhood dermatomyositis and polymyositis.


Syncope in a 65-year-old woman after nitrate ingestion.


OVERVIEW: Diagnosis of diabetes mellitus (DM) type 1 results in medical disqualification for all military aviation duties all over the world.


In animal models, cesium chloride has induced cardiac arrhythmias, including torsade de pointes.


Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis.


Children seem to be unusually sensitive to the depressant effects of clonidine.


Abdominal wall metastases from ovarian cancer after laparoscopy.


However, the extremely rare occurrence of complications related to perforation of the bladder can be detrimental.


Because of its unusual appearance, the name serpentine supravenous fluorouracil hyperpigmentation is suggested for this entity.


In addition to resuming her opioid therapy, she was treated supportively with bilevel positive airway pressure, diuretic therapy, morphine, aspirin, metoprolol, enalaprilat, intravenous heparin, nitroglycerin infusion, and dopamine infusion.


All patients were successfully treated with intravenous acyclovir.


The authors report two cases of acute dystonic reactions (ADRs) as a side effect of lamivudine.


Pathogenesis of methotrexate-induced papular eruption in psoriasis may involve immune mechanisms other than those of methotrexate-induced cutaneous vasculitis in collagen vascular disease.


The acute renal failure patients had neoplastic disorders and were considered to be septic at the time that multiple antibiotics were administered.


An immunocompromised patient, 6 weeks after bone marrow transplantation, developed extensive skin infection due to Trichophyton rubrum.


Atenolol-induced pseudolymphoma.


The patient received neoadjuvant chemotherapy for osteosarcoma and a left femur resection with endoprosthesis replacement.


Multiple superficial basal cell carcinomata--topical imiquimod versus curette and cryotherapy.


We regard the association recorded in this case to be a coincidence despite the known association between the drug and the development of immunosuppression and lymphoma.


Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.


In both cases, streptococcal pharyngitis was ruled out.


The considerable improvement remained for the 36 weeks studied.


His symptoms included bradycardia, hypotension, hypothermia, pallor, cyanosis, and impaired consciousness.


Enalaprilat induced acute parotitis.


Clinical features compatible with mixed hepatocellular and cholestatic liver disease including jaundice, white stools and dark urine, manifested in all three cases whereas encephalopathy and ascites were present in two of the patients.


PET scintigraphy of etoposide-induced pulmonary toxicity.


Disseminated histoplasmosis manifesting as a soft-tissue chest wall mass in a heart transplant recipient.


Early CAD recurrences may have been underestimated previously, because asymptomatic recurrences seem to be more frequent than symptomatic ones.


Two cases of continuous ambulatory peritoneal dialysis-associated peritonitis due to Plesiomonas shigelloides.


She was transferred to our hospital after she developed pancytopenia, fever, and ileus.


Mitomycin-C induced hemolytic uremic syndrome: a case report.


This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.


He was treated with imatinib 400 mg/d, which improved his general condition with few adverse effects.


We present a case of a 20-year-old woman who ingested 900 mg of glyburide causing refractory hypoglycemia resistant to treatment with intravenous dextrose, glucagon, and diazoxide.


Her body mass index (BMI) was 26.5.


Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


An infant presented 10 days after removal of a high umbilical arterial catheter with total occlusion of the distal abdominal aorta.


We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.


The pathophysiology, risk factors, diagnosis, and treatment options for this complication are discussed.


A major limitation in the use of amphotericin B is its potential to cause nephrotoxicity.


Pulmonary symptoms include cough, wheezing, sputum production, dyspnea, hemoptysis, tachypneas, and pleuritic pain.


This finding was repeatedly documented both clinically as well as during electrophysiologic testing.


Clinicians should be aware of this potential severe adverse drug reaction and therefore frequent control of hepatic enzymes is mandatory during treatment with pegvisomant.


She was transfused with four (4) units of packed cells and Zidovudine was replaced with Stavudine.


Histopathological studies from specimens taken by transbronchial biopsy showed bronchiolitis obliterans with fibrosing alveolitis.


Warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for marantic endocarditis.


Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.


He suffered from serious bleeding episodes requiring prolonged hospitalization and the disarticulation of the left knee joint.


Autopsy revealed that cortical and subcortical structures were normal without neuronal necrosis or eosinophilia.


Fatal hypoglycemia after cytotoxic chemotherapy: a report of two cases and a review of the literature.


A 47-year-old woman presented to our clinic 1 day after an intervention for a tibial shaft fracture because of sudden onset of chest pain and palpitations.


However this is only the second case reported in the literature, and the first in English.


CONCLUSIONS: Sympathomimetics have long been associated with intracerebral hemorrhage.


Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.


Acute pancreatitis is a rare but known complication of inflammatory bowel disease in adults.


Traditionally, children with acute lymphoblastic leukemia receive prednisone, as part of multiagent remission-induction chemotherapy.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.


Examination revealed a very ill looking pale patient with abdominal distension, tenderness and rectal bleeding and easy bruisability.


METHODS: In nine eyes (eight patients) with visually significant pigmented cellular membranes on their Allergan Medical Optics (Irvine, California) silicone intraocular lenses (model SI18NGB or SI26NB), eight underwent combined phacoemulsification, intraocular lens implantation, and trabeculectomy; one underwent phacoemulsification and lens implantation only.


Symptoms improved after discontinuation of mesalamine.


Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.


The clinical symptoms were associated with pronounced (CD4) lymphopenia and a marked increase in serum immunoglobulin A levels.


The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.


It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.


In turn, it may cause inflammation in such rapidly dividing tissues as the corneal epithelium, conjunctiva, and tear duct.


Acute pleuropericarditis after coronary stenting: a case report.


The patient presented with a painful eye and increasing vertical diplopia.


This is an endocrine emergency that can lead to respiratory failure, dysrhythmia, and death.


Optic neuropathy in ethambutol-treated renal tuberculosis.


This is a report of a case of a 53-year-old woman undergoing treatment with Xyrem for narcolepsy.


The abscess was surgically drained, the IUD removed, and a prolonged course of amoxycillin/clavulanic acid given.


Knowledge of the stage of dental development at the time of oncology treatment and the type of therapy allows the clinician to predict dental effects of the chemoradiation.


Aspirin was substituted for acenocoumarol, and the patient returned home after 10 days without sequelae.


Skin necrosis after extravasation of low-dose vasopressin administered for septic shock.


Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia.


Asterixis induced by carbamazepine therapy.


An unusual case of psoas abscess complicating one of the earliest performed ileo-anal pouch anastomoses is reported.


Clinical trials are warranted to test these effects.


Myotonia associated with sarcoidosis is rare.


Fungal-related ICD infections have rarely been reported, and little is known about the presentation, prevalence, and treatment options for these morbid infections.


Alternatives to neurosurgery, such as pharmacotherapy, include systemic corticosteroids and antidepressants.


We report five cases of carboplatin (CBDCA) hypersensitivity after weekly low-dose paclitaxel (60 mg/m2)/CBDCA (area under the concentration curve = 2) therapy in patients with recurrent ovarian cancer receiving multiple platinum-based chemotherapy.


The diagnosis of bromide intoxication is often aided by the detection of a low or negative anion gap due to the laboratory detection of bromide as chloride.


No safety data in patients with < 60,000/mm(3) of platelets are present.


In two of the infants, the rhythm was converted to sinus, but the third infant required direct current cardioversion.


No other anti-infective therapy was given.


This is the first report on the use of charcoal haemoperfusion for acute poisoning in Australia.


Anterior chamber paracentesis for aerobic and anaerobic cultures may be an appropriate initial diagnostic step in suspected cases.


This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.


Raynaud's phenomenon is a common vascular side effect of chemotherapy drug regimens.


We treated a patient with lung cancer in whom a hypercoagulopathy was induced acutely by chemotherapy.


These 14 pregnancies resulted in four live infants who had no apparent birth defects, one live-born infant with multiple defects, four spontaneous abortions, and five induced abortions.


METHOD: We describe a successful rescue of a 46-year-old man with recurrent hepatitis C (HCV genotype 1b) using long-term interferon (IFN) and ribavirin.


Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors.


Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery.


However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.


Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.


In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.


CONCLUSION: It is possible that pseudophakic eyes that develop intense conjunctival hyperemia associated with ocular hypotensive lipids might be at higher risk for developing cystoid macula edema.


The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.


BACKGROUND: A 39-year-old male with multiple myeloma was admitted for treatment with melphalan and autologous stem cell reinfusion.


CONCLUSIONS: Rasburicase appears to be well tolerated and effective in lowering serum urate concentrations in the treatment of therapy-related TLS in neonates.


CASE: A perimenopausal woman was treated with acetic acid for abnormal Pap smear report (cervical intraepithelial neoplasia 1).


INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.


Easily reversible hypoxemia and hypotension induced by nimodipine.


Treatment with calcitriol.


Fulminant hepatic failure is a rare complication of disulfiram treatment for alcoholism.


Extramedullary disease is rare in APL.


We report here a patient with carcinoma of the cervix with recurrent abdominal and thoracic disease who was previously treated with concurrent cisplatin and radiation for local control of pelvic disease.


His anxiety proneness along with a dysphoric response to the neuroleptic were deemed responsible for these attacks.


Garlic burns.


Enterococcus avium, formerly "group Q streptococcus," has rarely been reported as a pathogen in humans.


This is the first use of G-CSF in a paediatric renal transplant recipient, and its use should be considered for the immunosuppressed child with persistent neutropenia.


Conventional angiography and magnetic resonance angiography showed transient stenosis of the left vertebral artery.


The mechanism of this cholestasis is not clear at present.


These observations, although based on a single case, provide strong evidence that testosterone may exert powerful antidepressant action in the absence of concomitant antidepressant agents.


Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.


Dasatanib, which has been approved for rescue therapy for patients with imatinib-resistant chronic myelogenous leukemia and Philadelphia chromosome positive acute lymphoblastic leukemia, is a novel, orally available multitargeted kinase inhibitor of BCR-ABL and SRC family kinases (Quintas-Cardama et al, J Clin Oncol 2007;25:3908-14).


Two months before his death, severe varicella developed complicated by pneumonia, jaundice, and prolonged fever; all of which resolved during a five-week hospitalization.


Report of a case.


Serum hormone concentrations in these patients did not change during therapy, neither did the edema factor C1-esterase inhibitor.


Treatment is also presented.


Small-bowel obstruction during enzymatic treatment of gastric bezoar.


The results of the histological study and chemical tests are reported, and the etiology and the pathogenesis are discussed on the basis of the pertinent literature.


The rate and length of administration, as well as the dose, should be carefully monitored to avoid these complications.


Subsequent cardiac arrest and prolonged cardiogenic shock required aggressive pharmacologic support, intraaortic balloon pump insertion, and mechanical ventilation.


A right subhepatic abscess complicated a case of cesarean delivery.


Clinical diagnosis was made on the confirmation of soft palate movements synchronous with an audible clicking noise.


Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.


Early replacement therapy is recommended when proximal renal tubular abnormalities are detected to help prevent and control the severe metabolic bone disease associated with the Fanconi syndrome.


The evidence of high plasmatic levels of CBZ and the absence of other aetiologic factors lead the authors to conclude that the overdose of CBZ could have represented the precipitating of the episode of acute pancreatitis.


The improvements were more marked at 6 months and 1 year.


Coagulation activation and fluid retention associated with the use of black cohosh: a case study.


Treatment consisted of shunt removal and intravenous Amphotericin B in all cases and intraventricular Amphotericin B in 4 cases.


A case report.


Currently available antiviral agents have been unsuccessful in halting its progression.


He had been admitted because of necrotizing enterocolitis, at the age of 26 days.


Olfactory changes among patients receiving chemotherapy.


L-asparaginase-induced pancreatitis has been reported during or closely following administration of the drug.


Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.


Most cases are associated with phenylpropanolamine use.


We report a case of liver abscess caused by methicillin-resistant Staphylococcus aureus (MRSA), which developed as a complication of an infected VP shunt.


In addition, this case highlights the use of botulinum toxin as a guide for the potential successful management of compensatory hyperhidrosis prior to definitive extension of a sympathectomy.


Calcification and ossification of the spinal arachnoid after intrathecal administration of Depo-Medrol.


A 63-year-old African-American woman was admitted to the hospital with urosepsis and altered mental status.


A 71-year-old woman with a prosthetic heart valve, stabilized with warfarin, had international normalized ratios (INRs) maintained between 2.5 and 3.5.


Mental nerve neuropathy as a result of hepatitis B vaccination.


Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.


In addition, the patient experienced a delayed but accelerated puberty without any adverse events.


Three of the patients had been reluctant to reveal this to their psychiatrist, believing the doctor had no interest in alternative medicine or would disapprove.


The pulmonary toxicity is probably induced by piritrexim.


Tests for hypercoagulable disorders revealed antithrombin deficiency (antithrombin-heparin co-factor level = 30% [normal pooled plasma activity 70%-140%]), suggesting that it played an outstanding role in the LA thrombosis.


This observation suggests that endogenous estradiol may play a beneficial role in male patients with chronic hepatitis C.


Progressive disseminated aspergillosis in a bone marrow transplant recipient: response with a high-dose lipid formulation of amphotericin B.


I report a case of a previously healthy parturient who developed pneumocephalus and severe headache following the use of the loss of resistance to air (LORA) technique to identify the epidural space.


In all four cases, pain and erythema resolved within 2 days; in no case did tissue necrosis or skin ulceration occur.


CONCLUSIONS: Acanthamoeba keratitis can occur in association with SynergEyes contact lens wear.


Subsequently, the patient presented with a lower eyelid mass, which on excision was demonstrated to be a chalazion.


A fractured hip during electro-convulsive therapy.


Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.


This entity should be kept in mind when evaluating the acute abdomen in the HIV-positive patient.


Zidovudine induced pure red cell aplasia: a case report.


The causal relationship between hepatotoxicity and methylprednisolone treatment was deemed probable in both cases.


One explanation for the noted increase in the theophylline level is that metabolism occurs mainly by cytochrome P450 (CYP 1A2), an enzyme that is known to be inhibited with high concentrations of zafirlukast.


In cases such as these, initial vigorous therapy, including PEEP for hypoxia, corticosteroids for possible aspiration and volume replacement for hypotension, is recommended.


The association of hepatitis B virus infection and vasculitis or other immune-mediated manifestations is well documented.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Post-transplant lymphoproliferative disorders (PTLDs) are well-recognized complications of bone marrow and solid organ transplantation, comprising a heterogenous group of lymphoproliferations with a spectrum of morphologic, phenotypic and molecular features.


A patient with recurrent fungal endocarditis on prosthetic mitral valve is presented.


Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.


Recently, her serum theophylline levels had increased to the toxic range (133.2 micromol/L [24 microg/mL]) shortly after the addition of zafirlukast (Accolate, Zeneca Pharmaceuticals, Wilmington, Del) to her regimen.


These data indicated that infliximab possibly triggered production of granulocyte and neutrophil autoantibodies with resultant autoimmune agranulocytosis.


She had been diagnosed as having myotonic dystrophy by electromyographic investigations and abnormal serum creatinine phosphokinase (CPK) levels.


We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.


Although RA has been shown to confer a significant survival advantage in this disease, animal studies and a previous case report have suggested it could increase the toxic effects of chemotherapy and renal irradiation.


Routine intraoperative culture of the hip site grew Brucella sp.


Pulmonary hemorrhage should be considered in the differential diagnosis of patients who receive thrombolytic therapy in whom new roentgenographic pulmonary infiltrates present accompanied by decreases in hematocrit value.


Ketoralac is an injectable nonsteroidal antiinflammatory drug (NSAID) widely used in both out-patient and in-patient settings.


Vincristine overdose: experience with 3 patients.


OBJECTIVES: The objectives of this medicolegal case report were the following: 1) present details of a chronic pain patient (CPP) on chronic opioid analgesic therapy (COAT), who diverted her opioids and was terminated from treatment, and subsequently committed suicide; 2) present both the plaintiff's and defendant's (the COAT prescriber) expert witnesses' opinions as to the allegation of medical abandonment of this patient and other allegations; and 3) based on these opinions, to develop some recommendations as to how pain physicians can minimize their medicolegal risk when termination of the physician-patient relationship is warranted.


The diagnosis of tuberculosis was made by PCR from an open lung biopsy, while a bacterial culture was negative.


Pulmonary toxicity associated with erlotinib.


Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.


When both drugs were discontinued, his fever and rigidity subsided and biochemical irregularities spontaneously returned to normal, without any complications.


The frequencies and cytokine-producing phenotypes of phenytoin-specific T cells were examined simultaneously by using a carboxyfluorescein succinimidyl ester (CFSE) dilution assay.


One year later, he was readmitted to our clinic because of nonfunctioning tube and peristomal cellulites.


The objective of this paper is to provide data regarding early and suspected cases as well as offer guidelines for managing this condition.


After phakoemulsification, visual acuity improved to 20/50.


Patients were diagnosed with AL amyloidosis by tissue biopsy and categorized by performance status and organ involvement.


The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children.


We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.


Disseminated muscular cysticercosis with myositis induced by praziquantel therapy.


In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.


Ascending bacterial cholangitis can be a recurring complication in older children and adolescents who have undergone successful surgery for biliary atresia.


A 69-year-old male was diagnosed in February 2004 with stage IV extranodal marginal zone B cell lymphoma involving the mediastinal nodes, lung parenchyma and bone marrow with high LDH.


The second was an 82-year-old man receiving ticlopidine for 2 years when, during a febrile episode, he was found neutropenic with marrow aplasia.


CONCLUSIONS: These data demonstrate that rupture of the ventricular free wall can occur early after thrombolytic therapy and may have a subacute course.


The reported risk for developing acute leukemia after treatment of ovarian cancer ranges from 21 to 175 times that of the general population with a prevalence range in treated patients of 0.8 to 2.7%.


The lesions in the other two dogs resolved within 3 weeks to 3 months following discontinuation of the antibiotic.


Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.


Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.


The case illustrates the interaction of multiple viruses with accelerated progression to end stage liver disease and ultimately death.


Six patients with rheumatoid arthritis developed a syndrome resembling lupus erythematosus while being treated with penicillamine.


The patient in this case report was mentally impaired and had severe drug-induced gingival enlargement.


Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.


A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.


During the first days of arsenic trioxide treatment a rapid decrease in the D-dimers was seen (normal values reached until day 7), together with a slight decrease in peripheral blood leukocytes.


The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.


We report a case of mixed Aspergillus fumigatus and coagulase-negative Staphylococcus stromal keratitis in a 43-year-old man who developed discomfort and swelling in his right eye 20 days after uneventful bilateral laser in situ keratomileusis (LASIK).


The neurological changes that are common in the HIV population may complicate the use of analgesics, particularly opioids.


This case illustrates the role of the *3 polymorphism of the cytochrome P450 CYP2C9 as an independent risk factor modulating the sensitivity of patients to the anticoagulant effect of acenocoumarol.


Amyloidosis is the most severe complication of the disease.


Sodium thiosulfate, an inorganic salt that has been claimed to inhibit the formation and to favor the solubility and the mobilization of calcified masses, was administered to the patient, and after a long period of treatment considerable radiological regression of the TC with concurrent clinical recovery was noticed.


k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.


Documentation of cisplatin-related vascular events is important in view of the growing number of patients who undergo cisplatin-based chemotherapy.


Airway obstruction due to spontaneous retropharyngeal hemorrhage.


Vinblastine was excluded from the new regimen.


Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.


There has been no further recurrence in the long-term follow-up.


It was concluded that ANCA is closely related to the pathogenesis of crescentic glomerulonephritis and that treatment with PTU appeared to induce ANCA.


BACKGROUND: External beam radiation therapy often is avoided in the treatment of rhabdomyosarcoma (RMS) in young children because of the long-term sequelae.


RESULTS: At our institution, no children appeared with acute INH neurotoxicity in the period 1985 through 1990, whereas seven patients were treated from 1991 through 1993.


The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.


CONCLUSIONS: In our reported case, a local hyperproduction of TNF-alpha from macrophages that was induced by the injected insulin could explain the dedifferentiation of the adipocytes of the subcutaneous tissue and the reversion that was induced by the local injection of dexamethasone.


After removing the methotrexate, administering intramuscular iron and undertaking a gluten-free diet, the histological and analytical alterations progressively resolved.


Cancer patients who are receiving 5-FU treatment and are DPD deficient can develop severe side effects.


Basic drugs were screened for by liquid-liquid extraction followed by gas chromatography-nitrogen-phosphorus (GC-NPD) and gas chromatography-mass spectrometry-electron impact detection utilizing both in-house and commercial search libraries.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


Acetazolamide-accelerated anticonvulsant osteomalacia.


After delivery, clearance rapidly returns to preconception levels, enhancing the risk of adverse reactions in both mothers and breast-fed infants if the dose is not sufficiently reduced.


Case 1 presented after 25 months of myelosuppressive therapy a deletion of chromosome no. 12, del (12) (p11), in 60% of the diploid cells.


These cases highlight that nitritoid reactions can be severe and may be heralded by milder symptoms.


The patient responded successfully to withdrawal of the drug and treatment with antihistamines.


OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.


CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.


We suggested that the development of hyperlipidemia was related to the carnitine deficiency.


Clinical signs included central nervous system symptoms (69%), gastrointestinal complaints (87%), visual disturbances (69%) and metabolic acidosis (94%).


SETTING: Medical intensive care unit at the University of Chicago, Chicago, IL.


Some cases run a chronic severe course and fail to respond to local and systemic therapy.


Hepatic angiosarcoma associated with androgenic-anabolic steroids.


Results: Four of the aviators continued on active duty for years.


Over a two month period, these patients presented to the accident and emergency (A&E) department with acute dental pain, outside normal working hours, having been unable to access emergency dental care.


Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.


A 24-year-old woman with type 1 neurofibromatosis receiving long-term baclofen therapy was admitted with presumed pneumonia which was successfully treated with antibiotics.


Although weight gain often coincides with hyperglycemia in patients taking atypical antipsychotics, it does not seem to be a necessary causal factor.


All patients had varying degrees of evidenced high tumor burden, including lymphocytosis, elevated lactate dehydrogenase values, bulky tumor masses, and bone marrow involvement by lymphoma.


Therefore, data from large randomised, multicentre studies are needed to definitely answer the question of the relationship between safety and efficacy of this promising treatment option.


After discontinuing the drug, his edema resolved.


This article presents a technique for removal of a porous resurfacing acetabular component with minimal bone loss.


CONCLUSION: The minimum effective dose of im gold is not known.


Hemolytic uremic syndrome (HUS) is a rare clinical and biological entity.


Regional lipiodolized chemotherapy for cholangiocarcinoma associated with oral contraceptives.


Intrahepatic cholestasis and sicca complex after thiabendazole.


Diffusion-weighted magnetic resonance imaging showed a lesion in the posterior inferior cerebellar artery territory.


CONCLUSION: During and after IFN therapy, OCT is a useful examination technique for revealing macular edema in patients who have decreased vision.


Corneal edema recurred when the administration of amantadine was resumed.


Pulmonary arterial blood pressure and wedge pressure were significantly elevated.


We report two cases of central venous catheter-related Rhodotorula rubra fungemia that occurred in patients with acute myeloblastic leukemia.


Endometrial "sarcomas" complicating ovarian thecoma, polycystic ovarian disease and estrogen therapy.


Cyanamide-induced liver dysfunction after abstinence in alcoholics: a long-term follow-up study on four cases.


Clostridial orthopedic infections: case reports and review of the literature.


When questioned, he denied taking any other drugs including other alternative medicine approaches or vitamin supplements, particularly retinoids, well known for causing severe nail dystrophy.


Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.


The isolated organism was Acanthamoeba.


Little is known regarding etiologic risk factors, optimal management, and prognosis.


This article describes three cases that illustrate possible rationales for combination antidepressant therapy: reduced side effects, synergistic treatment effects, reduced treatment response time, prescriber familiarity, and clinical experience.


Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.


A 31-year-old Black male with a history of hypertension, partial seizures, and schizophrenia developed acute rigidity closely followed by severe hyperpyrexia (temperature 102 degree F), tachypnea, and tachycardia.


The other patient is also in remission and on maintenance treatment for leukemia.


M. marinum was cultured from the lesions and also identified by PCR on formalin-fixed tissue.


Prosthetic valve thrombosis is associated with high mortality.


Leishmania infantum leishmaniasis in corticosteroid--treated patients.


Based on these observations and data in the literature, they discuss a possible relationship.


Danazol and multiple hepatic adenomas: peculiar clinical findings in an acromegalic patient.


Genotyping of CYP2B6 and therapeutic drug monitoring in an HIV-infected patient with high efavirenz plasma concentrations and severe CNS side-effects.


The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar spine or pelvis.


Para-aminosalicylic acid-induced hypoglycaemia in a patient with diabetic nephropathy.


Jarisch-Herxheimer reaction.


CASE SUMMARY: A 75-year-old white man received 23.6 grams of ofloxacin over a 51-day period for epididymitis.


Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.


I also describe agents that are used to treat common problems in PD patients, including hallucinations, orthostasis, nausea, erectile dysfunction, depression, and memory loss.


This profile should trigger a "red flag" as to the possibility of phenobarbital behavioral side effects or exacerbation of preexisting maladaptive behaviors.


After several days of heparin therapy, the dialyzer circuit thrombosed and the platelet count decreased to 82 x 10(3)/mm(3).


Oculomotor disturbances associated with 5-fluorouracil chemotherapy.


Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care.


N. asteroides sepsis subsequently developed, leading to his death.


A patient with Hodgkin's disease developed acute radiation pneumonia four months after completion of mantle radiotherapy and during cyclical adjuvant chemotherapy.


This new approach may represent improved therapy and prevent the hazards of catheter exchange and systemic antibiotic therapy.


An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase.


The benefit of antithymocyte globulin in severe aplastic anemia in the pediatric age group was assessed.


Elevation of the blood lactate concentration by alkali therapy without requiring additional lactic acid accumulation: theoretical considerations.


To date, there have been no recorded cases of lichenoid drug eruptions (LDEs) caused by clinical use of the nonsteroidal anti-inflammatory drug salsalate.


The data substantiate previous findings in brain tissue from a patient with pyridoxine-dependent seizures.


A heightened awareness of this possibility may therefore lead to recognition of more cases and further understanding of this entity.


There are a few case reports on hair loss associated with tricyclic antidepressants and serotonin selective reuptake inhibitors (SSRIs), but none deal specifically with paroxetine.


The patient remained hospitalized for 3 months.


The case of a pregnant woman with a breast mass that proved to be a granulocytic sarcoma is presented.


We conclude peripheral neuropathy with 5-FU is rare.


INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.


Both patients responded to intravenous administration of diazepam 10 mg and were given levetiracetam as maintenance therapy.


Life-threatening hyperkalemia induced by arginine.


Interaction between tacrolimus and nefazodone in a stable renal transplant recipient.


Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.


He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil.


The goals of treatment are mainly preventative, i.e., cessation of steroids as soon as possible and protective bracing of the remaining intact Achilles tendon.


These findings suggest that the corneal and retinal changes are the result of a toxic effect of tamoxifen when used in the doses and duration described.


CONCLUSION: The present findings suggest that: (i) amantadine probably exerts its anti-dyskinetic effect by acting on the "indirect" pathway; (ii) the pathophysiological mechanisms of subthalamotomy induced dyskinesias may differ from those involved in L-dopa induced dyskinesias; (iii) dyskinesias induced by STN surgery resolve spontaneously as compensatory mechanisms develop.


This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.


Drug-induced pericarditis mimicking Brugada syndrome.


ADAMTS13 was normal in four patients and mildly decreased in two patients.


A 67-year-old patient, with primary polymyositis and without previous evidence of liver disease, developed clinical and biochemical features of severe cholestasis 3 months after initiation of azathioprine therapy.


Electroencephalography showed abnormalities of the type associated with metabolic disturbance.


CLINICAL PRESENTATION: We report two cases with multiple sclerosis, who developed meningioma four and twenty years after the diagnosis of MS was made.


The hyperglycemia once again resolved with discontinuation of the drug.


The T4 (helper)/T8 (suppressor) ratio decreased (1.0 and 1.2) on two different days, although above the normal limit.


In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.


Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.


OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.


Analgesia was not compromised by the use of donepezil, and in some cases it appeared improved.


Amoxapine-induced cognitive impairment in two patients.


CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.


PCR analysis showed CMV-DNA in the failed graft.


DISCUSSION: The causal association between anticoagulant therapy and spontaneous hemothorax remains relatively uncommon.


Although they had only a few nodules at diagnosis, the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients.


Sweet's syndrome is an acute febrile neutrophilic dermatosis that is a known complication of the administration of filgrastim, a drug that causes increased neutrophil proliferation and differentiation.


This hypofluorescence line enlarged over the time.


Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.


G-CSF also enhanced expression of the transferrin receptor (CD71) on blast cells in vitro.


PURPOSE: To describe the clinical and electrophysiological findings in a young boy with decreased vision possibly due to retinal damage by rifabutin.


In the oncology patient, chemotherapy, corticosteroids and bone marrow transplantation (with associated preparation therapy) have all been implicated as possible causes.


Because there have been no reports of endoscopic observations of bacterial ventriculitis, we were unable to be certain about the origin or significance of the microgranulations.


We recently dealt with a case of severe OHS presenting features of liver dysfunction; such a case has not been reported on before.


Although a rechallenge was not tried, this case appears to demonstrate a temporal relationship between the initiation and discontinuation of metoclopramide and the onset and resolution of symptoms.


On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.


We describe a case of a woman with subarachnoid haemorrhage who developed hypocalcaemia and decreased serum parathyroid hormone levels due to hypermagnesemia.


A lupus-like syndrome associated with infliximab therapy.


He was asymptomatic at presentation and physical examination was unremarkable.


Cryptococcal infections are seen mainly in immunocompromised hosts.


RESULTS: Three patients (one woman, two men) with a mean age of 76.3 years developed neovascularization at the L-CRA site and underwent treatment as described with a mean follow-up time of 7 months.


PURPOSE: To report 4 cases of Toxoplasma gondii retinochoroiditis in patients having recently undergone cardiac transplantation.


A reticular pattern on high resolution CT (HRCT) invariably represents significant lung pathology and is the dominant feature of irreversible fibrosis.


One child did not achieve detectable concentrations on 2 different study days and was switched to a different protocol.


Postdural puncture cerebral spinal fluid (CSF) leak most often manifests as a postdural puncture headache (PDPH).


Alcohol withdrawal syndrome (AWS) is a major cause of morbidity and mortality in the acute care setting.


Severe deterioration in cognitive function and personality in five patients with long-standing diabetes: a complication of diabetes or a consequence of treatment?


Over the next several months, she continued to require supplemental calcium, magnesium, potassium, and phosphorus.


Familial, dexamethasone-suppressible, normokalemic hyperaldosteronism.


Postmortem examination showed leukemia infiltration of the liver and spleen.


Combined central retinal artery and central retinal vein occlusion following pars plana vitrectomy.


The patient developed unusually severe hematological toxicity to chemotherapy as compared to nonsmall cell lung cancer patients without the GD defect.


METHOD: The Hospital case note of a 27 year old widow with HIV infection and anaemia, who has been on HAART (Zidovudine, Lamivudine and Nevirapine) for one year, was reviewed.


This is the first report of a possible association between an acute cardiovascular event and venlafaxine.


We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis.


Our case shows that clinical symptoms of polymyositis improved with steroid and immunoglobulin treatment without deterioration of the hepatitis B.


Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.


When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction.


Myasthenic patients receiving ampicillin should be closely monitored for possible acute exacerbations.


The latter case was diagnosed by needle aspiration of the cyst.


MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis.


Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers.


This methodology provides the decision analyst with a procedure to evaluate the outcome of specification uncertainty, in many decision problems, without resorting to Monte Carlo analysis.


The patient suffered from progressive anemia with the lowest hemoglobin level of 21 g/L.


RESULTS: Steroid-dependent SNHL was confirmed on audiological evaluation.


RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.


A maintenance dosage of only 100 mg/day has resulted in significant improvement of depression and panic attacks, with discontinuation of psychotropic medication.


The second case depicts acute CNS toxicity with known fatal potential.


CONCLUSION: This experience indicates that cetuximab can be continued in patients who experience infusion reactions.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


'Bail-out' bivalirudin use in patients with thrombotic complications unresponsive to conventional treatment during percutaneous coronary intervention.


The lesion was successfully resected using cardiopulmonary bypass, and the diagnosis of metastatic osteogenic sarcoma was confirmed.


Unrecognized pre-existing renal insufficiency (CKD Stage 2 - 3) and the continuation of spironolactone were identified as predisposing risk factors.


There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.


We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis.


DHP often reduces the number of platelets, also DHP needs a lot of heparin, therefore, we should have performed HD alone instead of DHP.


Children with acute lymphoblastic leukemia (ALL), treated with L-asparaginase are at risk for cerebral thrombosis or hemorrhage because of coagulation protein deficiencies.


Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.


CONCLUSIONS: In patients with coronary artery disease, or in situations where cardiovascular stability is desired, glycopyrrolate is an effective means of relieving intraoperative penile erections.


Computed tomography re-evaluation demonstrated a new liver lesion.


Five patients required short-term dialysis.


Clinical measures and outcomes were recorded prospectively.


CONCLUSIONS: This observation of "on-off" risperidone treatment suggests that risperidone may have worsened both psychiatric and physical manifestations of the mitochondrial disorder in this adolescent.


Use of portable blood analyser in prehospital care should be considered in case of suspected massive poisoning by ethylene glycol.


Endotracheal intubation eventually was performed.


We report a case of intentional self-poisoning with tiagabine.


Biopsies taken at the time revealed a dense inflammatory infiltrate consistent with an abscess.


When glucocorticoids are used for longer than brief periods, even in moderate dosages, they can produce a variety of adverse effects, including steroid diabetes.


In this paper we present the first doxorubicin extravasation through a central catheter in adults and review the only ten cases found in the literature.


Nonconvulsive status epilepticus: the role of morphine and its antagonist.


When headache recurred and meningeal signs appeared, SAH was diagnosed by computed tomography in all three cases.


Early neurovascular and/or neurometabolic imaging identified the location of occlusion and tissue-at-risk (DWI-PWI mismatch) in all 8 patients.


Two patients had clots in the pump.


A 54-year-old male presented to our hospital for evaluation of peripheral lymphocytosis.


In this case report, we describe a child with biliary atresia who underwent a living LDLT and developed severe coagulopathy after reperfusion of the graft.


Therapy with pyrimethamine, sulfadiazine and folinic acid resulted in total lesion healing although central vision was lost.


Acromegaly increases the overall risk of neoplasms.