We report here such a case with bilateral Mooren's ulcer that failed to respond to local therapy with topical corticosteroids, silver nitrate, and conjunctival resection, as well as systemic immunosuppression with corticosteroids, cyclophosphamide, and azathioprine.


Pregnancy complicated by endodermal sinus tumor of the ovary is extremely rare.


This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.


It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity.


This review provides an evidence and experience-based approach to the preventive treatment of migraine.


Successful treatment of bronchiolitis obliterans in a bone marrow transplant patient with tumor necrosis factor-alpha blockade.


There are reports of accelerated SSc syndromes associated in particular with breast cancer.


This case report highlights a need for awareness of increased bleeding as a potentially serious complication associated with the use of all currently licensed PIs in individuals with hemophilia.


The second was a 36-year-old male who developed mental status changes, ataxia and dysarthria following treatment for lymphoma.


The patient developed severe and suicidal depression which responded solely to testosterone.


She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.


Minimally invasive repair of a left ventricular pseudoaneurysm after surgical patch reconstruction of an infarct-related free posterior wall rupture: CT-guided intervention.


The four other North American cases are reviewed, and the epidemiology of the infection in animals is discussed.


The initial manifestations of the disease on admission included cough, dyspnea, hemoptysis, pulmonary infiltrate, and renal failure.


Acute respiratory depression as a complication of nebulised morphine.


Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.


Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.


In uncontrolled digestive haemorrhage, a short course of somatostatin therapy can be of great help in controlling the acute bleeding and to avoid emergency laparotomy.


Dermatomyositis is associated with malignancy in approximately 20-25% of cases.


Permanent complete relief or pronounced improvement of the dyskinesias was observed at a dosage of 5 mg prednisolone/day.


The Ommaya reservoir provides an easy and practical method for fungicidal medication administration.


Care must be taken in the management of lumbosacral intradural tumors because tumors resembling neurilemmoma may in fact represent meningioma, some subtypes of which possess a high rate of recurrence.


The authors treated two children with Gilles de la Tourette's disease and one child with a probable combination of Gilles de la Tourette's disease and minimal brain dysfunction with methylphenidate, which resulted in exacerbation of symptoms.


Clinically apparent reactivation of hepatitis B virus typically occurred 1 month after the 3rd dose of infliximab.


The authors describe the clinical and pharmacologic management of a patient who developed an organic affective syndrome during a simulated deep-diving experiment.


Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney.


The rash was treated with moisturizing cream along with intravenous and topical corticosteroids and antibiotics.


We describe a 50-year-old woman with rheumatoid arthritis in whom a severe postinjection vasomotor reaction was associated with a cerebral vascular accident.


The most common symptoms were mental status disorder and involuntary movements.


A detailed description of the cardiac event is provided for one patient who was on a cardiac monitor during the adverse reaction.


Rifampin-impregnated silicone catheters: a potential tool for prevention and treatment of CSF shunt infections.


Approximately 5-6% of intravaginal clindamycin is absorbed in the bloodstream, making systemic effects possible.


The present study retrospectively investigated the utility of a novel combination chemotherapy regimen for treating multifocal HCC resistant to TAE.


CONCLUSIONS: JHR should be an anticipated reaction to early doses of antibiotic treatment for treponemal diseases, such as syphilis.


Therefore patients with bronchial asthma should receive special prophylactic attention.


The previous amphotericin B, granulocyte colony-stimulating factor, hyperbaric oxygen and nasal and left maxillary sinus surgical debridement therapy was ineffective in stopping the progression of the infection to the brain.


In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.


Postmortem examination revealed only minimal neoplastic infiltration of the meninges.


We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.


BACKGROUND/OBJECTIVE: Intrathecal baclofen is considered standard treatment for severe spasticity of spinal cord and cerebral origin.


These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.


Pantoprazole therapy was promptly discontinued, and prednisone 40 mg/d was initiated.


Bilateral loss of vision in bright light.


We present a patient with documented pacemaker related left-sided endocarditis associated with an acute embolic stroke who was treated with antibiotics with complete recovery and its two-year follow up.


Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.


Characteristic muscarinic, nicotinic and central manifestations of OP poisoning appeared: atropine and 250 mg obidoxime i.v., resulted in marked improvement.


Erosion of psoriatic plaques after chronic methotrexate administration.


These patients would then not experience EPS and would be more likely to continue with their medication in the long term and thus avoid relapse.


The patient herein reported had chronic obstructive pulmonary disease and had had a nephrectomy.


Milk-alkali syndrome can present serious and occasionally life-threatening illness unless diagnosed and treated appropriately.


The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.


Physical examination revealed hypotension (84/47 mmHg) and heme-positive stool on rectal examination.


Their positive, negative, and general symptoms as rated by the BPRS also decreased significantly.


Toxic manifestation includes myoclonus, ataxia, confusion and sudden death.


Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning.


Two patients are alive at 16.4 and 22.5 months after initial treatment.


This is the third patient with severe FUra toxicity secondary to an alteration in pyrimidine catabolism and the second from our clinic population suggesting that the frequency of this genetic defect may be greater than previously thought.


The patients whose glucose control is dependent on counter-regulatory hormones should be monitored for the possibility of hypoglycemia.


Methemoglobinemia: an occupational hazard of phenylpropanolamine production.


After aprotinin infusion (loading dose of 2 x 10(6) kIU followed by a continuous infusion of 5 x 10(5) kIU/h) combined with heparin, bleeding vanished until the end of bypass.


These experiments have confirmed clinical observations that alcohol in modest doses has the potential of producing atrial or ventricular arrhythmias.


Symptoms of CIPS were not observed.


She had been treated for pulmonary tuberculosis seven years prior to admission.


Approximately 80% of akinetic-rigid syndromes are due to Parkinson's disease.


The patient died of recurrent myocardial ischemia 3 days postoperatively.


The half-life of survival of those who ultimately died was 2 months.


Extrapyramidal side effects: a historical perspective.


The disease started to heal after treatment with topical clobetasol propionate 0.05% and sun exposure during the following summer.


Because lupus patients are susceptible to infections associated with disease exacerbation or immunosuppressive treatment, recurrent infections might be expected during the disease course without need for further evaluation of the immunodeficiency.


The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.


Cutaneous eruptions occur in 3% of individuals administered carbamazepine.


They discuss related literature reports of mania or rapid cycling after adjunctive estrogen administration for refractory depression.


Rat islets of Langerhans exposed to mefloquine in vitro (10(-8) mol/l to 10(-3) mol/l) secreted significantly more insulin than control islets (up to 980 +/- 180 microU/ml/5 islets incubated with mefloquine 10(-3) mol/l, vs 20 +/- 4 microU/ml/5 untreated islets).


Forty patients with HCM were treated with calcium-channel blockers such as nifedipine, diltiazem, and verapamil.


Sputum cultures were positive for methicillin-resistant Staphylococcus aureus, and intravenous vancomycin 1 g every 8 hours was added to the treatment regimen on hospital day 7.


Two other cases of shunt infection during the same time period were treated for only 2 days with intraventricular vancomycin and did not manifest CSFE.


One patient was found to possess *5/*10; the other had a *1/*5 genotype.


We report a 56-year-old woman who was found to have bilateral pulmonary nodules four months after cardiac transplantation.


She had a stormy course despite adequate antimicrobial therapy.


Physicians utilizing rituximab should be aware of this association given the difficulty of differentiating between presentations of BOOP and neoplastic pulmonary processes.


Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.


These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).


We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.


CASE: Because of menorrhagia, the patient had begun an oral contraceptive pill (OCP) 1(1/2) months prior to presentation.


The toxic effects of imatinib treatment are usually mild, and serious adverse events are rare.


Both authors discuss a method of creating a postauricular pocket, burying the ear pedicle, and using costal cartilage for an inlay helical graft.


The histological findings of marked cholestasis without evidence of extrahepatic biliary obstruction or acute hepatitis were compatible with the diagnosis of drug-induced liver disease.


Spindle coma in benzodiazepine toxicity: case report.


We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.


She had been receiving oral colchicine therapy for mixed connective tissue disease.


A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment.


D-penicillamine was withdrawn and glucocorticoids combined with azathioprine were given with good recovery of renal function.


After five months of initiation of treatment, while receiving RHE, he developed painful bilateral gynaecomastia.


We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).


The present case is a young adult who had severe almost continuous hiccups for 3 years after placement of a feeding gastrostomy and Nissen fundoplication.


OBJECTIVE: To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.


This likely explains the noted response to a calcium channel blocker (CCB), namely diltiazem.


A bone marrow aspiration showed slight hypoplasia with normocellular marrow.


Tegaserod, a potent partial agonist of the serotonin 5-HT4 receptor, is used to treat women with constipation-predominant irritable bowel syndrome.


The carers assessed the pre-morbid and present behaviour and personality of the patients using standard questionnaires.


In addition, cardiac adverse effects usually develop after at least 6 days of therapy.


As in this case, infection may be systemic and not confined to the intestine.


This combination was shown to be synergistic.


Most patients showed some element of dose dependency between antiparkinsonian drugs and the hypersexual behavior.


Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.


Biochemical parameters of liver cell damage returned to normal levels 6 months later.


CONCLUSION: COCs can be used in patients with thrombogenic mutations and anticoagulatory therapy in individual cases.


Audiograms showed bilateral sensorineural hearing loss with cochlear lesions.


Acute spontaneous spinal epidural hematoma: an important differential diagnosis in patients under clopidogrel therapy.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


The induced hyperglycaemia could not be controlled sufficiently, despite a high dose of insulin (> 110 units/day), suggesting the existence of insulin insensitivity and hyperinsulinaemia.


Prior reports have emphasized the tubular and interstitial lesions associated with intermittent or discontinuous rifampin therapy for tuberculosis.


Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results in progressive, irreversible obstructive pulmonary disease.


PURPOSE: The purpose of this study was to evaluate the differential diagnosis of pulmonary nodules by conventional radiography and computed tomography (CT) in osteosarcoma patients with central venous catheter.


We present a case of cutaneous leucocytoclastic vasculitis in which amphotericin B might presumably be the aetiological factor.


Three men and 2 women aged 38 to 53 years were treated.


The pitfalls of potassium replacement in thyrotoxic periodic paralysis: a case report and review of the literature.


He was treated with phenytoin from the age of 2 years and 7 months.


In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.


Administration of cidofovir was associated with clearance of BK virus DNA from blood and stabilization of renal function in 5 cases.


Methemoglobinemia associated with dermal application of benzocaine cream in a cat.


Over several weeks, all neurologic and imaging deficits resolved.


Continued study of the specific mechanisms leading to ventricular tachycardia and sudden death are needed in order to control this increasingly prevalent clinical problem.


Most new drug therapies require randomized data to show effects before widespread use and acceptance occur.


Twenty patients with bladder cancer were treated by semiselective intra-arterial chemotherapy with Adriamycin.


We report a case of a 26-year-old woman, who presented with an itchy erythematous reaction and strong oedema localized to the face.


Since continuation/maintenance ECT is not well established, prophylactic therapy in recurrent illnesses is more commonly carried out using antidepressive medication alone or more often in combination with lithium.


There is almost always a hypopyon present, and the uveitis progresses aggressively.


The second patient, a 60-year-old woman, was hospitalized because of a corneal ulcer in her left eye.


Histological examination of a skin biopsy was consistent with leucocytoclastic vasculitis.


Other pharmacologic interventions, based on the physiology of erections, are presented.


Initial pulse oximetry on room air was 72% and improved minimally with supplemented oxygen.


The multidisciplinary team's successful decision to trial SFG in a medically complex patient allowed profound iron deficiency to be treated safely and effectively, which was not possible prior to the availability of an alternate iron preparation.


CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.


Specifically, for children with a family history of gallbladder, biliary tract, liver or pancreas dysfunction, ceftriaxone may not be the drug of choice since the likelihood of complications is increased in this population.


A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.


A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.


At autopsy adenovirus was identified in her bladder, kidneys and lungs.


We report here three patients with hematologic malignancies and one patient with metastatic carcinoma with chemotherapy-induced leukoencephalopathy.


Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.


Acute leukemia after cytotoxic treatment for nonmalignant disease in childhood.


We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline.


We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.


Until the frequency of this adverse reaction is clearer, it would seem advisable to ensure that plasma HDL cholesterol is documented before and rechecked after commencement of thiazolidinedione therapy.


Lithium medication during pregnancy is uncommon and the problems of a neonate who has been exposed to lithium represents a rare situation in neonatology.


Early recognition and treatment of postpartum preeclampsia may decrease patient mortality and morbidity by preventing late postpartum eclampsia.


A ten year old boy who died of the consequences of an infrequent gastrointestinal complication, whilst on induction chemotherapy for acute lymphatic leukemia, is being reported.


Despite the large number of cases with mediastinitis described in the literature, the chest closure with only an omental flap without closure of subcutaneous tissue and skin is rare.


The optic nerve appeared healthy, with no visible swelling in each eye.


The dental surgeon can play an important role in the diagnosis and treatment of such patients.


At follow-up 1 week later, the patient denied any episodes of hematochezia.


Unlike fusarial infection in patients with hematologic malignancies or bone marrow transplants, fusarial infection in SOT recipients tends to be localized, occurs later in the posttransplantation period, and has a better outcome.


RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score.


A desensitization regimen was administered, and she has tolerated all subsequent courses of carboplatin therapy.


The patients had a history of several hospitalizations and one or two unnecessary laparotomies.


The difference in DGTX concentration between the unprocessed and dialysed samples was the amount of DGTX bound to plasma proteins and the small fraction of unbound DGTX being relevant for the therapeutic and toxic effects of the drug.


No anti-Xa activity was demonstrated in breast milk.


Here we report two cases with HBV carrier status and with non-Hodgkin's lymphoma who were successfully treated with high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation with the administration of lamivudine to prevent HBV flare-up.


However, because serious hematologic toxicity has been reported, we recommend caution in administration and careful monitoring of blood levels.


This case is particularly important as the condition will become more and more prevalent and therefore it is imperative that GDPs in primary care are aware of it.


The period of recovery was consistent with an acute but brief compressive injury and inconsistent with an anesthetic effect.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


The patient did well until developing a rapidly progressive lesion of the left neck.


Onset of male gynaecomastia in a patient treated with sunitinib for metastatic renal cell carcinoma.


Prolongation of the prothrombin time after organophosphate poisoning.


Treatment of cavitary pulmonary zygomycosis with surgical resection and posaconazole.


The infusion was terminated and his symptoms abated.


A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.


Reviewing our experience with 19 cases of male breast cancer, we found two patients with a 12-year history of estrogen therapy for prostatic carcinoma.


We have concluded that opioid drugs cause bile duct obstruction in healthy persons.


Increased libido in a woman treated with fluvoxamine: a case report.


A 66-year old woman with acute pancreatitis was admitted to our hospital with the complaint of epigastralgia radiating to both flanks for two months.


Administration of rituximab during the first trimester of pregnancy without consequences for the newborn.


Acute ocular ischemic change may be associated with intravitreal injection of bevacizumab in patients with vascular compromised diabetic retinopathy and/or underlying stenosis of the carotid artery.


At the age of 14 months a diagnosis of congenital adrenal hyperplasia was made and treatment with dexamethasone (0.125 to 0.25 mg/day) resulted in a fall-off in growth rate, normal advancement in bone age, decrease in virilization and suppression of 17- ketosteroid excretion which continued until 4 3/12 years of age when virilization increased.


Her serum transaminase and albumin levels were normal.


Disopyramide (Norpace)-induced hypoglycemia.


OBJECTIVE: This case study provides general practitioners with a practical approach to seeing patients with chronic pain whom they suspect of opioid dependence and describes a framework for managing chronic pain and dependence within the general practice setting.


Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.


On examination, she was slightly confused, mildly dehydrated, had a grade II systolic ejection murmur along the upper left sternal border, had bilateral and symmetric mild weakness of the upper and lower extremities, and exhibited mild edema of the lower extremities.


We describe a patient in whom noncardiogenic pulmonary edema developed during intrabiliary infusion of monooctanoin.


Starting with the 8th hospital day, the thrombocyte count steadily increased from 410000/microl to a maximum of 1132000/microl on hospital day 16.


Despite spontaneous revascularization of many of the lesions, subchrondral collapse caused symptomatic secondary degenerative arthritis in many joints.


We report a case of fatal C. neoformans fungemia in a neutropenic patient with a history of chronic lymphocytic leukemia treated with alemtuzumab.


The means whereby this agent might injure oseophageal mucosa are discussed.


Although the patient had no symptoms 10 hours after intrathecal treatment, to prevent the possible neurotoxic effects of methotrexate, a cerebrospinal fluid exchange was performed.


Two attempts at carboplatin desensitization were unsuccessful.


The use of high potency topical steroids for the treatment of oral vesiculoerosive diseases seems to have been a contributing factor in two of these cases.


Clinical use of oral contraceptives administered vaginally: a case report.


Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.


Pneumatosis intestinalis associated with immune-suppressive agents in a case of minimal change disease.


It has been approved by the Food and Drug Administration for 24-h use.


Two fatal cases of poisoning by paracetamol are described.


A 2-month course of sucralfate and cimetidine was used and successfully produced symptomatic relief as well as complete normalization of the dysplastic changes.


All seven patients who were given an oral formulation of cyclosporine tolerated it well after a reaction to the intravenous infusion.


Hypokalemic sensory overstimulation.


This article presents a case of an atypical localized cutaneous eruption with an unusual course and protracted resolution time associated with sorafenib therapy.


These findings are consistent with recent in vitro literature, which implicate a series of neuroleptic medications with mitochondrial dysfunction.


One month after cataract surgery in the right eye, the best-corrected visual acuity was right 6/6 (-1.25) and left 6/10 (-2.00/-0.50 x 100).


Six weeks after admission, abscess material was grown on Mycoplasma culture medium yielding U. urealyticum in high titres.


A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.


Granular parakeratosis.


CNS angiitis in graft vs host disease.


Such cases could prove an interesting locus for the investigation of both affective disorders and tardive dyskinesias.


Patients with metastatic disease to the bone marrow are at risk of significant hematologic toxicity, if they undergo myelotoxic chemotherapy.


Two patients received no further anticoagulation, and two received continuous heparin within 24 hr of implant to maintain activated clotting times of 140-150 sec.


In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.


Monocomponent porcine insulin was injected into each quadrant of the pit.


Although they had complex medical problems, the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy.


In this complicated patient, who was resistant to oral warfarin and unable to receive subcutaneous low-molecular-weight heparin, therapeutic anticoagulation was achieved with intravenous warfarin.


Danazol induced thrombocytopenia.


In the present paper, we report four very elderly patients (80 years of age or older) with primary nephrotic syndrome.


With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.


Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product.


Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs used in the treatment of ventricular and paroxysmal supraventricular tachyarrhythmia.


Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.


Azathioprine (AZA) is an immunosuppressant commonly used for organ transplantation and autoimmune diseases.


This article is a guide to its usage in children and includes discussion of its indications, contraindications, pre-treatment laboratory studies, dosing and drug interactions.


The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.


A patient with acute esophageal variceal bleeding developed fatal rhabdomyolysis during treatment with a continuous intravenous infusion of vasopressin.


Dissemination occurred under voriconazole.


A second case involves a 21-year-old woman who substituted generic carbamazepine because of financial problems.


These side effects include agranulocytosis, seizures, and cardiorespiratory symptoms.


Although lymphomas are known to emerge in the setting of immunosuppressive therapy, it has not been well described or established for the newer biologic immune response modifiers.


CONCLUSIONS: Intravenous therapy with the anti-CD20 antibody rituximab is a nontoxic and effective treatment for patients with primary cutaneous B-cell lymphoma.


She achieved complete remission, but one year later had a relapse in her external auditory canal without leukemic cell in the bone marrow.


In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.


Despite an elevated "endogenous" Epo level, a greater than 1.5 g/dl increase in hemoglobin (Hb) concentration was observed in one patient with refractory anemia (RA), one patient with refractory anemia with excess of blasts (RAEB), and one patient with AA.


Auditory damage may be reduced by changes in dose, drugs or methods of treatment.


Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.


Although systemic nocardial infections traditionally have had a grave prognosis, through early diagnosis, surgical intervention, and the use of newer, safer and synergistically acting antimicrobials, the prognosis has improved.


Biopsies of the iliac crest demonstrated the presence of severe osteomalacia and massive deposition of aluminum in the bone.


After processing to reduce its toxicity, 'maqianzi' was used as a herbal remedy for rheumatism, musculoskeletal injuries and limb paralysis.


Progressive pulmonary fibrosis complicating cyclophosphamide therapy.


A magnetic resonance imaging scan obtained 7 weeks after the injection showed a full-thickness tear of the supraspinatus tendon.


We report here a rare case of pleuropericarditis due to methotrexate.


An additional feature peculiar to these 2 cases was the presence of unexplained extramedullary hematopoiesis.


Also, we have reviewed selected features in eight patients who took overdoses of chloral hydrate who were admitted to an intensive care unit between 1981 and 1988.


Six amino acid mutations were located in the 'a' determinant, including P120T, K122R, M133T, F134L, D144A and G145A.


Light microscopy of a renal needle biopsy specimen showed interstitial lymphoid cell infiltration, but no marked changes of the glomeruli and no staining for immunoglobulin or complement.


Marked improvement of psoriasis or arthropathy occurred in each case without side effects.


It causes transient atrioventricular nodal block and thus ends paroxysmal supraventricular tachycardias that involve the atrioventricular node.


Neurologic examination and brain magnetic resonance imaging (MRI) were normal, but interictal EEG showed left frontal epileptiform activity.


Immediate diagnosis and treatment of the perforated appendicitis saved the life of the patient.


Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment.


We suggest that the sagittal sinus thrombosis in this patient was caused by acquired, transient free protein S deficiency.


Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation.


Ifosfamide-associated neurotoxicity was noted within hours of drug administration and improved rapidly following hemodialysis.


Blood sugar and A1c were finally stabilized one month after discontinuation of olanzapine (A1c,6.9%).


Acute renal failure due to crystal deposition in the urinary tract was well described 30 to 40 years ago and is likely to resurface as a clinical entity if appropriate prophylactic measures are not taken.


Its use in reproductive age women has become increasingly common in recent years, intensifying the risk of fetal exposure.


MAIN OUTCOME MEASURES: Clinical signs and symptoms of ITB withdrawal of varying severity were assessed by vital signs (temperature, heart rate), physical examination (reflexes, tone, clonus), and patient report of symptoms (itching, nausea, headache, malaise).


Review of the literature revealed 34 patients received chemotherapy and radiotherapy, 32 patients received chemotherapy alone, 1 patient had only surgery, and the radiation status of the remaining patient is unclear.


CONCLUSION: A woman receiving enoxaparin every 12 hours developed signs and symptoms of hepatotoxicity after the second dose.


These cases underscore the importance of careful examination of the retinal periphery before management of any presumed optic neuropathy with steroids.


However, the proteinuria apparently became worse.


The onset of symptoms after fluorescence in both cases is highly suggestive, although the pathogenetic mechanism is not clear.


Risperidone is a frequently used member of a new class of atypical antipsychotics-the serotonin-dopamine antagonists (SDAs)-due to its comparatively high efficacy and low D2/5HT2 binding ratio, which results in a low incidence of extrapyramidal side effects including tardive dyskinesia (TD).


Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?


We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).


However, during the treatment, he developed a pulmonary embolism.


Close monitoring for toxicity and dosage manipulations might be required if such therapy is attempted.


No other recognized causes of rhabdomyolysis were identified on retrospective review of the hospital course.


The isolation of Kluyvera as a pathogen in transplant patients emphasizes that this commensal organism may be virulent in this patient population.


As this was not seen in patients without Down's syndrome, we postulate that patients with trisomy 21 have bone marrow which is "at risk" for suppression, and, thus warrant close evaluation while on such medications.


Report of four cases and comparison with autoimmune hepatitis.


Chronic irritation of the gastric antral mucosa led to ulceration and formation of hyperplastic polyps.


CONCLUSION: WE and thiamine deficiency should be considered in all patients with malabsorption, malnutrition, and malignancies.


Although great advances have been made in the pharmacotherapy of schizophrenia, many patients are still not taking full advantage of the beneficial effects of antipsychotic drugs.


One half hour following the ingestion of a possibly tainted antibiotic capsule, a 14 year-old female experienced acute onset of stiffness and weakness in her lower extremities.


The extra care required may negate the financial advantages of the substitution.


However, cough mixtures are a readily available source of opioids.


Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.


To our knowledge, this paper is the first to describe long-term experiences with patient reporting as part of a spontaneous reporting system.


The failed graft obtained during the additional PKP was subjected to PCR analysis and histopathological examination.


Clinicians and patients should be made aware of this possible complication of topical bimatoprost therapy.


Future investigations evaluating the efficacy of adjunctive antibiotics for purulent SSTIs and monitoring the incidence of SJS/TEN in the era of CA-MRSA are necessary to reduce unnecessary use of sulfonamide drugs.


Gynecomastia associated with theophylline.


We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.


Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis.


RESULTS: Topiramate was discontinued.


Risk factors for neurotoxicity include renal insufficiency, underlying central nervous system (CNS) disease and increased CNS penetration of drug.


We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy.


The dog responded well to conservative therapy for immune-mediated hemolytic anemia (IMHA).


A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.


The median survival was 17 months in patients who had received no prior treatment, and 5 months in those who had received prior chemotherapy.


On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.


A 42-year-old man with ankylosing spondylitis that was refractory to nonsteroidal anti-inflammatory drugs as well as various disease-modifying antirheumatic drugs was subjected to anti-TNF compounds.


Rapid development of keratoacanthoma and accelerated transformation into squamous cell carcinoma of the skin: a mutagenic effect of polychemotherapy in a patient with Hodgkin's disease?


Multiple white dandruff-like flakes were seen on the hair coat, especially over the dorsal spine and neck, and the dog expressed increased pruritus by frequently licking and scratching the affected areas.


In the first 2 cases, injections were perilesional and in the other 2, intralesional.


We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.


INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative.


Successful recovery from interstitial pneumonitis, induced by bicalutamide and leuprorelin acetate given as treatment for prostate cancer.


Paraplegia following intrathecal cytosine arabinoside.


Recurrent agranulocytosis induced by two different antithyroid agents.


In this report, a case is described of C. indologenes bacteraemia possibly associated with the use of a peripheral venous catheter.


The fact that oxcarbazepine is a prodrug and that the formation of the active MHD metabolite is a rate-limiting process may contribute to the relative low toxicity of the drug in overdose.


Drug-drug interactions are an important concern, as they may increase drug toxicity and, in the case of anticoagulant therapies, increase the risk of hemorrhage.


Post-transplant lymphoproliferative disorder (PTLD) is associated with Epstein-Barr virus (EBV) and characterized by fever, lymphadenopathy, and graft dysfunction.


Jpn J Ophthalmol 2005;49:231-234 (c) Japanese Ophthalmological Society 2005.


Her urine output improved gradually and the serum creatinine normalized one month after the initial episode.


Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.


The case described here suggests an immune-related mechanism for the development of leukopenia.


Other reports show increases with the atypical antipsychotics, olanzapine and quetiapine.


A 42-year-old woman had uneventful bilateral laser-assisted subepithelial keratectomy (LASEK) to correct myopia.


A 69-year-old man presented with a rare case of retinal artery embolization, which occurred as a complication of carotid angioplasty and carotid artery stenting performed for recurrent cerebral infarction.


DISCUSSION: AIDS and cryptococcal meningitis, both of which the patient had, can potentially cause seizures.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


CONCLUSIONS: This treatment modality appears to provide an additional alternative for managing superficial periocular hemangiomas which threaten vision.


Clinical and pathological responses of tumor and the side-effects were examined in these two groups.


We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.


Fertility was preserved because 7 months later the woman became pregnant and had an uncomplicated pregnancy and delivery at term.


All 3 patients died.


An 81-year-old female presented to her local emergency department (ED) with symptoms of bronchitis and was treated with nebulized bronchodilators.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


Magnetic resonance imaging showed reversible cortical and subcortical changes consisting of high-intensity lesions on T2-weighted and fluid-attenuated inversion recovery sequences with postgadolinium enhancement, low signal intensity on diffusion-weighted imaging and increased apparent diffusion coefficient.


Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis.


This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.


A potentially fatal complication of these anesthetics is methemoglobinemia (Met-Hgb).


In the first two infants there was a documented deficiency of vitamin D, but in the second two adequate supplementation was achieved.


Pharmacokinetic interactions between medications can have clinically significant effects.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Further interrogation of the patient revealed a history of chronic senna intake to treat a chronic constipation.


We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.


CMV disease involving central nervous system is an unusual presentation in the setting of SCT.


Morphine sulfate in controlled-release tablet form is a relatively new oral preparation being used for the relief of chronic severe pain, such as that related to cancer.


Presented here is the successful treatment of adenomyosis in a woman presenting with menorrhagia, dysmenorrhea, and an enlarging uterus, for whom conservative therapy initiated with mefenamic acid was unsatisfactory.


We believe that the acute renal failure in our patient was associated with anastrozole.


The rapid onset of osteomyelitis was impressive.


Systemic vasculitis complicating hairy cell leukaemia treatment with cladribine.


The patient had advanced malignant mesothelioma and all other methods of pain control had been unsuccessful.


Clinicians need to maintain a high index of suspicion to diagnose and treat this life-threatening adverse event.


One-half of the women interviewed reported seeing an advertisement for prescription acne treatment before taking Accutane.


We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).


Colonic mucosal necrosis following administration of calcium polystryrene sulfonate (Kalimate) in a uremic patient.


It follows that in any case of hymenoptera envenomation a standard ECG is advisable even when a clearly defined allergic reaction is not present.


CONCLUSIONS: The risk of drug-induced rhabdomyolysis due to the potential interaction between lovastatin and azithromycin or clarithromycin should be considered before the concomitant use of these agents.


Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.


We report a case of cytomegalovirus retinitis which occurred 6 months after renal transplantation and was successfully treated with an investigational drug, ganciclovir (DHPG [Dihydroxy propoxymethyl guanine], Cytovene, BW-B759U), via intravenous administration, with resolution of active retinal lesions and the cessation of cytomegalovirus shedding in the urine.


At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.


The highest intraoperative oxygen concentration was 33 percent, but 40 percent oxygen was administered for four days postoperatively.


The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.


Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.


It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.


Digoxin is a cardiac glycoside used to treat cardiac arrhythmias and heart failure.


METHODS: We reviewed the records of two patients with a clinical diagnosis of Acanthamoeba keratitis, one with culture-proven Acanthamoeba and the other with a suspected Acanthamoeba infection.


This was associated with opening the mouth and was thought to be caused by a trigeminovagal reflex.


(It is no longer contained in Correctol.)


We believe this case represents a rare complication of anticholinergic therapy.


Mycophenolate mofetil is a novel immunosuppressive drug already established in transplantation medicine.


Cisplatin and acute tubular necrosis.


BCG therapy prevents, or at least delays, tumor progression.


CT scans assessed the local extent of the tumor and ruled out metastatic disease prior to initiating therapy.


Three patients, 2 with tardive dyskinesia and 1 with senile chorea, were successfully treated with corticosteroids during an observation period of up to 5 months.


DESIGN: Observational case report.


The changes were quantitatively and qualitatively similar to those seen in systemic lupud erythematosus induced by these drugs.


She was successfully carried through pregnancy and delivered a normal child despite combination chemotherapy.


Our diagnosis was tuberculosis-related visual loss, which could be due to neuroretinitis, intraocular tuberculosis or chiasmal tuberculoma.


A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.


Initial laboratory studies showed severe hypophosphatemia and elevated alkaline phosphatase and serum 1,25-dihydroxyvitamin D levels.


We report a patient who experienced LABD shortly after starting carbamazepine therapy.


After three days of salicylate therapy her LFT values began to rise.


Endophthalmitis developed in the eye and was treated by pars plana vitrectomy, IOL extraction, and intravitreal antibiotic injection.


AIMS: To investigate the combination of raltitrexed and mitomycin-C as first-line chemotherapy treatment in patients with advanced colorectal cancer.


Protease inhibitor-induced carbamazepine toxicity.


It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.


The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.


We observed a case of withdrawal after abrupt discontinuation of mianserin.


The ocular and myopic changes cleared up completely on discontinuation of the causative agent.


Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.


Transrectal ultrasonography of the prostate demonstrated an average decrease in prostatic volume of 58% at 6 months, with the greatest rate of decrease occurring during the 2nd to 5th months of treatment.


We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.


Post-radiation necrosis of the larynx is a major complication after irradiation and has become rare.


The post-therapy biopsies also showed progestin-related alterations but no evidence of active hyperplasia.


Proposed mechanisms for leukemogenesis are presented.


Acanthamoeba keratitis after LASIK.


Two months later, he was admitted to hospital with ORTHOPNEA, worsening dyspnea and cough.


We describe 3 cases of diphenhydramine-induced cardiac toxicity that were responsive to bicarbonate.


The patient was brought back to a normal sinus rhythm after a single 300-J counter-shock.


We suggest discontinuing gemcitabine if radiation recall is observed.


Thirty-three patients with primary ovarian malignancy were treated with cisplatin-based combination chemotherapy ranging from 1 to 12 (mean 4.6) cycles.


To date, there have been few reports of visual disturbances associated with BTX-B use.


Histological examination of the liver revealed inflammatory reactions, cholestasis, occasional steatosis, and necrosis.


CONCLUSION: TLS is an uncommon, but potentially life-threatening, complication in melanoma and other solid tumors.


The role of anticoagulation with heparin is controversial in the absence of any controlled studies.


This report describes a probable case of infliximab-induced membranous nephropathy.


We report a 5-year-old boy with CF who had a stricture of the hepatic flexure region with associated narrowing due to submucosal fibrosis of the transverse colon, secondary to high-lipase pancreatin therapy.


Microangiopathic hemolytic anemia (MAHA) is a late but fatal complication in advanced cancers (cancer-associated).


CONCLUSION: Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration.


The microbiology culture was negative.


Laboratory tests revealed creatine kinase (CK) 7952 IU/L, lactate dehydrogenase 1021 IU/L, myoglobin 2322 U/L, and aspartate aminotransferase 362 IU/L, resulting in a diagnosis of iatrogenic rhabdomyolysis.


Some much-quoted early studies noted abnormalities in liver function tests (LFTs) in very obese patients taking high doses, although there was no evidence of clinically significant liver dysfunction.


Medical consultation is imperative for these patients before administering a fluid challenge during general anesthesia.


Fever, pulmonary infiltrates, and pleural effusion following acyclovir therapy for herpes zoster ophthalmicus.


Metabolic acidosis induced by acetazolamide.


Motor neuropathy, anemia and all gastrointestinal symptoms disappeared.


Tricyclic antidepressant toxicity treated with massive sodium bicarbonate.


SUMMARY: Unfortunately, the clinical features of the oral adverse effect from NVP are not well known.


Histopathological findings included signs of orthokeratotic hyperkeratosis, moderate follicular keratosis and light epidermic acanthosis.


Serum creatinine remained above pre-treatment values in seven patients.


We report a patient who developed early onset PCP after allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA-identical sibling donor.


We describe a patient with systemic lupus erythematosus and impaired renal function probably mainly due to tubulointerstitial disease.


Right atrial thrombus and recurrent pulmonary emboli secondary to permanent cardiac pacing--a case report and short review of literature.


The patient did well after the operation and returned to normal activity.


Additionally, a baby bottle allegedly administered to the infant was collected as evidence and sent to the Medical Examiner's Office for evaluation.


Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine.


We report on a case of an adult patient treated for rheumatoid arthritis with infliximab, a chimerical monoclonal antibody to TNFalpha.


Anasarca eventually subsided within 4 weeks with the use of a diuretic agent.


Single and multiple verrucous plantaris lesions are well known for their resistance to conservative methods of treatment.


He developed a painful symmetrical purpuric eruption over both feet after three days.


Patient 2 is a 53-year-old man who underwent fibular osteocutaneous free-flap reconstruction of a floor of mouth defect who developed venous thrombosis 6 days postoperatively.


Clear guidelines and access to support are often lacking.


Platelet count less than SHARP: what does a case series reveal?


Anaphylactic reaction to bacitracin ointment.


An abdominal radiograph revealed gross fecal loading.


Consequently, intravenous salmon calcitonin was administered, based on evidence of efficacy in the treatment of other neuropathic pain syndromes and its relatively benign side-effects profile.


OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.


The paper outlines the correct treatment and discusses the deleterious effects of incorrect administration of drugs in WPW syndrome.


There are many challenges associated with treating invasive aspergillosis, particularly that due to A. terreus, and the early use of caspofungin should be considered.


A 29-year-old woman who underwent laser in situ keratomileusis (LASIK) for myopic astigmatism in both eyes presented with severe pain, photophobia and decreased visual acuity in the left eye eight days after surgery.


Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.


All patients showed marked improvement clinically, endoscopically, and histologically.


DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.


Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction.


Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.


Photo-onycholysis caused by olanzapine and aripiprazole.


The authors report a case of a 12-year-old girl who had rare self induced photosensitive epilepsy.


It is likely that RA contributed to the deterioration in renal function in these patients.


The cessation of angiographic leakage on FA was achieved in all eyes (100%) after IVB, however the hypofluorescent line delineating the margin of the neovascular tissue appeared in ICGA seemingly according to the contraction of mCNV.


Systemic lupus erythematosus and IPH were diagnosed 6 years later.


The results of the comparative study led us to the conclusion that the compression technique is a simple and valuable means of decreasing the side-effects of Adriamycin and increasing tumor response.


In the second case, mild atypical change by presence of nuclear enlargement and rare mitotic figures were noted and PCNA, KI67 levels were less than 2%.


INVESTIGATIONS: Physical examination, blood and urine analyses, kidney biopsy and tonicity balance.


We assumed this to be related to the advancing central nervous system aspergillosis.


Although tandem scanning confocal microscopy of Acanthamoeba has been described in previous reports, Acanthamoeba keratitis has not been fully characterized with this instrument.


OBJECTIVE: To report the late development of immune-mediated diabetes mellitus after completion of alfa-interferon therapy for hepatitis C in an Asian patient.


Blood transfusion and natural infection cases.


Bland emollients and reduction in the dose of PLD resulted in resolution of the eruption.


Morbidity included extended hospitalization, dialysis, and chronic renal failure.


The neurotoxicity seen with HDARAC is dose-related and has occurred in up to 60 percent of treated patients.


Serum lithium levels fell rapidly, but the cognitive impairment associated with the delirium typically persisted for another week or two.


Warfarin-associated bleeding complication saved life.


Exacerbation of schizophrenia associated with amantadine.


Myasthenia-like syndrome induced by cardiovascular agents.


Postoperatively, a continuous epidural infusion of fentanyl/bupivacaine was used for postoperative pain management.


Six cases of subacute sclerosing panencephalitis (1 stage I, 3 stage II, 2 stage III) were diagnosed at our institution in the last 10 years.


Cimetidine is a rare cause of drug-induced fever.


Initially, DSCG had helped to control his asthmatic attacks, and steroid therapy could be discontinued.


Case presentation, management, and etiology are discussed.


She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.


Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.


Esophageal spasm following propranolol overdose relieved by glucagon.


Acute occlusion of the popliteal artery, a limb-threatening complication, was reported after total knee arthroplasty.


Steroid utilization in eosinophilic jejunitis: beneficial or harmful?


Probable propafenone-induced transient global amnesia.


Clonally rearranged immunoglobulin heavy chain JH gene was not detected by Southern blot analysis.


The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.


Personality factors and drug effects in a controlled study of cyclazocine.


No patient died of INFVA.


An additional 15 asymptomatic patients who were receiving high doses of oral niacin (1.0-6.0 g daily) for the treatment of hypercholesterolemia were evaluated for evidence of subclinical macular disease.


We present a case of chronic postoperative Propionibacterium acnes endophthalmitis in which the diagnosis was made by anterior chamber paracentesis, and topical, periocular, and systemic antibiotic therapy resolved the inflammation.


No other common disease known to affect mitral valves nor intake of other drugs (ergot derivatives or appetite suppressant drugs) was found.


Our experience with donepezil in this group of patients shows promise.


Skin biopsy specimens of lesional areas showed a bullous eruption consistent with erythema multiforme.


The 38-year-old patient with no previous cardiac or smoking history developed complete heart block, ventricular fibrillation and subsequent asystole.


Edema is an adverse event associated with thiazolidinedione therapy The potential for mild-to-moderate peripheral edema with thiazolidinedione is known, especially in patients who have heart failure or use insulin.


A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed.


We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.


The present authors report the case of an adult with chronic granulomatous disease who developed an unusual lung fibrosis associated with severe pulmonary hypertension.


DPD activity was normal in both patients.


Postoperative pyoderma gangrenosum (PPG), also known as postoperative progressive gangrene of Cullen, is a rare and rapidly evolving complication of surgical procedures.


Although, a systemic steroid taper was employed in 10 out of the 14 patients before the development of the skin lesions, the subsequent progression of the skin lesions was not influenced by the use of systemic steroid therapy.


The authors present a case report of a granulomatous reaction leading to urethral prolapse, 3 months after the transurethral injection of calcium hydroxylapatite.


The alveolar form of hydatid disease, caused by the larval stage of the cestode Echinococcus multilocularis, is virtually confined geographically to the northern hemisphere.


These symptoms were transient and fully reversible.


Both patients developed massive subchorionic hematomas, which persisted in 1 patient who underwent cesarean delivery at 34 weeks of gestation for cardiac indications (Apgar scores 9 and 10 at 1 minute and 5 minutes, respectively).


It was postulated that the allergic reaction was most likely caused by capecitabine or the intermediate metabolites based on the immediate reappearance of symptoms from the rechallenge, pharmacokinetic data, and well-tolerance of fluorouracil.


CONCLUSION: During and after IFN therapy, OCT is a useful examination technique for revealing macular edema in patients who have decreased vision.


We found TPO and platelet responses to be generally antagonistic through all cycles.


RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated.


Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin.


The patient's asthma improved, and he remained asymptomatic; but routine study evaluations 9 to 12 months into therapy showed microhematuria, proteinuria, glucosuria, anemia, and renal insufficiency.


At that time, the present researchers began to explore the development of a school-based, methodologically sound, and inexpensive method of assessing the efficacy of stimulant medications, which would ensure reasonable compliance by teachers, parents, and students in monitoring the effects of medications and placebos.


CONCLUSIONS: The fundus picture shown in these cases may be typical of ASPPC after IVTA injection.


Herpetic reactivation may occur in many forms after excimer laser ablation.


Multiple foci of axonal degeneration and demyelination were found in the optic nerves and chiasm, the superficial layers of the brainstem, and spinal cord and to some extent in other cranial nerves and spinal nerve roots.


Two days after the start of administration of SKT, her severe pain was markedly improved.


Microsomal enzyme induction and clinical aggravation of porphyria: the evaluation of human urinary 6beta-hydroxycortisol/cortisol ratio as the index of hepatic CYP3A4 activity.


A case is reported of myoclonus induced by an antidepressant purported to have no effect on serotonin activity.


A 23-year-old Caucasian man diagnosed with stage IVB Hodgkin's disease was referred to a university oncology section after completing 1.5 cycles of chemotherapy.


This case shows that radioinduced SMN can occurr with relatively low doses of RT (<50 Gy) and that it may occur very late.


An urgent brain computed tomographic scan showed hemorrhage in the right cerebellum and subarachnoid region.


Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder.


Administration of the drug for 8 days did not effectively shorten the recovery period compared with the average reported in the literature without the drug, and may have triggered additional iatrogenic complications.


Late-developing but self-limiting neuropsychiatric complications occurred in four patients.


A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.


Leflunomide, an immunosuppressive drug used in rheumatoid arthritis and in rejection in solid-organ transplantation, has been reported to have novel anti-CMV activity.


Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.


Obstructive ileus is not common, but is a very distressing syndrome in a palliative care unit.


The most likely cause of liver failure in this patient was, therefore, clarithromycin, which undergoes hepatic metabolism and has been reported to cause fulminant hepatic failure.


A 61-year-old Japanese man with chronic myelogenous leukemia developed pityriasis lichenoides-like eruptions during chemotherapy.


Within 48 hours after discontinuation of the medication, she had complete resolution of psychotic symptoms, fatigue, and psychomotor retardation, and her depression improved.


Physicians must be aware that the public is still ingesting the drug and remain rigorous in including its toxicity in the differential diagnosis of acute neurologic events.


Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.


The possible mechanism is thought to be an allergic reaction to the drug.


Eighty-four percent of patients reported an increase in their sense of well-being.


We found that positive biopsies are usual only if the duration of symptoms have been allowed to persist for more than 6 months.


Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.


CASE REPORT: A 68-year-old woman experienced a severe febrile reaction after a plateletpheresis transfusion.


Visceral leishmaniasis and macrophagic activation syndrome in a patient with rheumatoid arthritis under treatment with adalimumab.


MR findings in methotrexate-induced CNS abnormalities.


BACKGROUND: Many patients receiving long-term total parenteral nutrition (TPN) develop liver disease; cholestasis is common and may be severe.


The fingernails were more affected than the toenails and clinically the changes consisted of absence of lunulae, longitudinal ridging, transverse or longitudinal defects of the nailplate and a tendency of onychoschizia.


We report that these tumors frequently express the CD-20 antigen, and immunotherapy directed at this antigen may be a well-tolerated and effective treatment.


After receiving conventional chemotherapy, they underwent multicyclic DI-CT consisting of CDDP, ETP and ifosfamide supported by G-CSF and ABPCT.


Combined data reveal that 12 of 23 have had a complete or partial response with residual thrombocytopenia and a probability of 48% survival one year from the start of ATG therapy as projected by life table analysis.


CONCLUSIONS: Amantadine can cause reversible corneal edema but can irreversibly reduce the density of endothelial cells.


Herpes simplex epithelial keratitis developed in four renal transplant recipients while they were receiving high-dose systemic corticosteroid and immunosuppressive therapy.


The most common hematologic SMNs are myelodysplasia (MDS) and acute myelogenous leukemia (AML).


Further surveillance and caution are suggested in patients with known coronary artery disease or atrial dysrhythmia.


She was receiving chronic therapeutic doses of HCQ for the treatment of lupus erythematosus.


Five patients experienced increased intraocular pressure to 30 mmHg or greater which required treatment.


Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.


With the increasing use of chemotherapy for many different primary malignancies, secondary or therapy-related acute myeloid leukaemias (AML) and myelodysplastic syndromes (MDS) are becoming more common.


Dosage varied widely, but as little as 0.1 mg caused significant signs and symptoms.


Alcohol neurolysis for persistent pain caused by superior cluneal nerves injury after iliac crest bone graft harvesting in orthopedic surgery: report of four cases and review of the literature.


This report addresses the issue of whether linear IgA bullous dermatosis can be associated with gluten-sensitive enteropathy.


The patient became cyanotic with a PaO2 of 39 mmHg.


These preliminary results indicate the possible advantage of adding an alkylating agent (prednimustine) to estramustine in advanced prostatic carcinoma.


Clinicians should be aware to this complication.


Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.


Blood cultures were negative.


The case report discussed is, to our knowledge, the third of its kind regarding bone fluorosis resulting from use of this nicotinic derivative.


Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproduction techniques using in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI).


Nitrofurantoin, one of the antimicrobial agents which should be chosen for the prophylactic treatment of recurrent urinary tract infection, may be prescribed in the conventional form or, alternatively, as macrocrystals.


The risk of infections and growth suppression is minimized by using small maintenance dosage and alternate day therapy.


The patient had also been taking concomitant allopurinol and captopril for more than 4 years with no complications, and valproic acid 3 months before the cutaneous event.


The patient who survived had been taking the lowest dose of azathioprine and was given the recommended dose of acyclovir.


The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.


Opioid drugs cause biliary sphincter spasm.


Attention must be paid to this complication because the outcome and functional prognosis are better when pulmonary involvement is gold related: in our case steroid therapy was life-saving and induced complete recovery of the lung damage.


A lymphocyte stimulation test was reactive to pranlukast.


We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.


Although the incidence of antimalarial psychosis is unclear and perhaps small, we recommend close observation of patients for behavioral changes suggesting the development of antimalarial psychosis.


The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.


There are several side effects that it is commonly associated with; however, it has only rarely been reported to cause lung injury.


In general, angiotensin converting enzyme (ACE) inhibitors should be discontinued in pregnancy, as they can induce an ACE fetopathy.


We report the first case of fulminant hepatic failure associated with its use.


On 26 April 1999, three persons were accidentally exposed by high dose (60)Co irradiation.


It is generally hypothesized to be due to a point mutation in the androgen receptor that allows the antiandrogen to function as an agonist, leading to a dramatic and rapid PSA response.


He rapidly recovered by intravenous hydrocortisone followed by oral prednisone administrations and percutaneous catheter pericardial drainage.


Combination chemotherapy for bone marrow relapse in childhood lymphoblastic leukaemia (ALL).


Because new drug therapies have been developed, it is important to know the interactions between antiretroviral and antiepileptic agents.


Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.


Hyperkalemia as a late side effect of prolonged adrenocorticotropic hormone therapy for infantile spasms.


The authors present a case report of a pregnant woman with persistent left adnexal mass and subsequently found to have a primary endodermal sinus tumor of the ovary that was diagnosed at 19 weeks of gestation.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


The implications are stressed in relation to the differential diagnosis of patients with gastroenterological disorders who develop peripheral neuropathy.


However, deterioration of his clinical state indicated LT.


We report three cases of amiodarone-induced torsades de pointe.


A report of two cases and review of the literature.


It generally results in painless bleeding or abdominal pain.


She was treated with high dosage corticosteroids and incurred severe side effects, including bone marrow depression, renal magnesium stones, osteoporosis, depression of affect, convulsions with cerebral damage and adrenal suppression.


The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.


Gold-salt therapy may result in damage to proximal tubules that leak renal tubular antigens, which in turn complex with autoantibody and produce an autoimmune membranous nephropathy.


Protamine is used widely to reverse the anticoagulant effects of heparin and to delay the absorption of insulin.


Acute psychosis associated with levetiracetam.


Difficulty with anticoagulation may still be experienced with the newer formulations.


Pituitary tumor made symptomatic during hormone therapy and induced pregnancy.


Five weeks after the diagnosis of systemic candidiasis, sudden anuria developed, and ultrasonography showed echogenic material in both renal pelvises.


We review the existing literature on AHS pathogenesis and illustrate a case complicated by liver dysfunction where the use of N-acetylcysteine (N-AC) and intravenous immunoglobulin (IVIG) may have altered the course of the disease.


The clinical course and histological findings are presented.


In two of these cases, it was sufficiently marked for the course of treatment to be curtailed and occurred at a relatively low cumulative dose of the drug.


However, an increasing number of case reports and clinical studies on thrombolysis during and after CPR highlight an increased frequency of the return of spontaneous circulation and a better neurological outcome of surviving patients.


According to our case report and to the literature, the onset of acute dyspnea after chemotherapy for lung metastatic germ cell tumor should alert to the possibility of spontaneous pneumothorax.


On January 22, laboratory tests showed normal values of CK, CK-MB, and myoglobin.


The patient subsequently underwent surgery for embolization of the right occipital and superficial temporal arteries and removal of the mass.


PURPOSE: The aim of this study was to discuss the potential implications of prolonged and aggressive treatment of long-term survivors of ovarian cancer.


Improved awareness and rapid treatment of the second patient had a favorable outcome with no sequelae.


RESULTS: In a 22-year-old Thai woman with Graves' disease, tinnitus, hearing impairment in the left ear (with progression to the right ear), and vertigo developed after 3 years of therapy with PTU.


Fatal acute encephalomyelitis after a single dose of intrathecal methotrexate.


We report three representative cases of sequential prostate specific antigen (PSA) elevation following initial response to this combined androgen blockade.


She was thus diagnosed as having AZ intoxication.


Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.


Hairy leukoplakia was first described in association with HIV infection.


Resorption of the haematoma was proven by abdominal ultrasonic follow-ups.


Frequently it is also used to treat chronic pain syndromes.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.


The tendency to develop AV block in a patient who is euthyroid was reduced by bypass tract conduction.


We report a case of recurrent, long-lasting familiar amnesia occurring after betablocker treatment withdrawal in a migrainous patient.


An objective causality assessment suggested that the increased mania was probably related to the decrease in VPA concentration and that a possible interaction exists between lopinavir/ritonavir and VPA.


Only one patient reported transient side effects.


Angioimmunoblastic lymphadenopathy (AILD) may respond to thalidomide treatment: two case reports.


Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF).


These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.


Two hours after ingestion of the drug, the plasma concentration of paracetamol was 3040 mumol/l.


CONCLUSION: Fixed drug eruption is associated with many drugs but this is the first such report with omeprazole.


RESULTS: Six patients with CSC were found to be chronic users of corticosteroid (four patients) or both beta adrenergic agonist and corticosteroid (two patients) metered dose inhalers or nasal sprays.


The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.


Transthoracic or better transoesophageal echo-cardiography and Doppler are by far the most accurate diagnostic tools that can entirely replace angiographic assessment.


Topiramate and metabolic acidosis: a case series and review of the literature.


The polymorphic UGT isoenzyme, UGT1A1 has genetic variants which decrease in SN-38 glucuronidating capacity and could help predict irinotecan-associated toxicity.


Despite reduction in the dose of immunosuppression and localized radiotherapy, the tumor had rapidly progressed to involve the soft tissue of the right hand.


A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.


She developed marked liver dysfunction.


DESIGN: Observational case report.


Failure to properly address parotid duct injuries that result from Mohs micrographic surgery exposes the patient to a variety of adverse sequelae.


The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.


Late postpartum eclampsia coincident with postdural puncture headache: a case report.


A patient developed optic neuropathy while being treated with isoniazid and ethambutol.


In the hospital, she continued to receive TPN without MVI, but continued taking an oral multivitamin preparation.


In this report a renal transplant recipient is described, who developed disseminated Nocardia asteroides infection with lung, eye, and brain involvement, in addition to coinfection with Trichophyton rubrum.


No major safety issues were observed during the study.


Transfusion-transmitted malaria in a kidney transplant recipient.


Effect of ramipril in a patient with glycogen storage disease type I and nephrotic-range proteinuria.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


We are reporting on a "very-very" late stent thrombosis that occurred 43 months post-implantation.


The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.


No cardiovascular disorder with the exception of minor ischemic changes in ECG was revealed before treatment.


Fenofibrate is a new lipid-lowering agent for adults with very high triglyceride levels that was administered to two HIV-positive patients who were taking protease inhibitors and developed hypertriglyceridemia.


A 5-year-old, spayed female German Shepherd dog was admitted to hospital with marked generalised lymphadenomegaly and splenomegaly.


Although gemcitabine-based regimens have clear efficacy in refractory lymphoma, prior mediastinal radiation without subcarinal blocking may be a relative contraindication, especially in the presence of pericardial abnormalities on echocardiography.


Pellagra should be suspected whenever tuberculous patients under treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical pellagra dermatitis.


The recipient cases were 46- and 25-year-old male patients who suffered from end-stage dilated cardiomyopathy and had been listed for cardiac transplantation in the Japan Organ Transplantation Network as status I candidates.


He presented with blurred vision.


Antenatal diagnosis of fetal goiter is crucial for the immediate postpartum management of these neonates.


However, we recently saw two patients with renal tuberculosis treated with ethambutol in whom visual loss from toxic optic neuropathies was severe and irreversible despite careful ophthalmological monitoring and prompt discontinuation of the agent at the first sign of impaired visual function.


The vomiting occurred on switching to different pancreatic enzymes preparations, ie, Creon 10, Viokase, and Pancrease MT 16.


Increased lens thickness contributes only minimally (9%-16%) to anterior chamber shallowing.


The risk of developing NMS under atypical neuroleptics seems lower than under typical neuroleptics.


Two of our patients developed TD after 23 months and 34 months of ziprasidone monotherapy, respectively.


These adverse reactions probably depend on the dose, metabolism and excretion of the drug.


Acute unilateral total visual loss after retrogasserian phenol injection for the treatment of trigeminal neuralgia: a case report.


The etiology of the chorioretinitis was confirmed by serology to be syphilis.


Youssef's syndrome: an appraisal of hormonal treatment.


Cerbral angiography revealed evidence of an arteritis with bilateral high grade carotid stenosis.


Nondural attachment intradural meningiomas are quite uncommon.


This is the second report of lactic acidosis in a patient on stavudine and lamivudine.


We present case reports of three different types of eye burns and later therapy resulting in corneal calcification.


On the second day of hospitalization, it was noted that the patient's dyspnea and sinus bradycardia could be related to a recent increase in his timolol dosage.


Ivermectin has been shown to be an effective treatment of loiasis.


We encountered a late pulmonary complication after umbilical cord blood transplantation (UCBT) that has not been previously reported.


Before discharge, at the age of 23 days of life, she started to be breast-fed from the mother.


Pyogenic liver abscess in Taiwan is most commonly due to Klebsiella pneumoniae infection in diabetic patients, and less frequently due to biliary tract infections.


The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.


Analysis of cerebrospinal fluid showed significant pleocytosis and hypoglycorrhachia.


Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.


At 8 weeks' gestation, she was started on candesartan cilexetil (an ARB).


Evidence regarding the remyelinating nature of human monoclonal antibodies raises interest in the potential therapeutic role these antibodies may have.


Corticosteroids have an established place in the prevention and treatment of nausea and vomiting due to emetogenic cytotoxic agents.


It is often misdiagnosed as multiple sclerosis (MS) from which it differs in its clinical presentation, course of disease and prognosis.


Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.


RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.


METHOD: Case report.


Kluver-Bucy syndrome: report of a case with nasopharyngeal cancer after irradiation and chemotherapy.


Acute promyelocytic leukemia after living donor partial orthotopic liver transplantation in two Japanese girls.


Here we describe the case of a 69-year-old patient who achieved a second complete remission with this association without additional toxicity.


This article reports the cases of two patients in whom a widespread dermatophyte infection mimicked the cutaneous lesions of their underlying collagen vascular disease.


This patient, who had a history of osteoarthritis, had severe hepatitis 5 weeks after being started on diclofenac for increasing pain in the joints.


A 64-year-old man with open-angle glaucoma had used topically applied epinephrine for 13 years.


Neuroleptic malignant syndrome and serotonin syndrome in the critical care setting: case analysis.


METHODS: We present a case in a 71-year-old man who underwent an operation for CPS fixation and laminoplasty for cervical spondylomyelopathy.


This report demonstrates that linear IgA bullous dermatosis can respond to gluten restriction if an underlying gluten-sensitive enteropathy is present.


We describe a case of SCC in vitiligo lesion after long-term PUVA therapy.


We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.


Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss.


She had not been envenomated by a rattlesnake previously or received any horse-derived antivenins in the past.


We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.


Any psychotropics of little clinical significance were then cautiously minimized.


OBJECTIVE: We report a rare case of delayed onset of cerebral infarction caused by an embolism after cervical pedicle screw (CPS) fixation.


We propose that our observations reflect an improved management of these patients, mainly because of the use of new antimycotics with alternative mechanisms of action and decreased toxicity, allowing for earlier, more aggressive, and more effective antifungal treatment approaches.


A second transient prostate-specific antigen elevation after external-beam radiation therapy and fractionated magnetic resonance imaging-guided high-dose rate brachytherapy boost.


In the absence of a congenital long QT syndrome, torsades is seen with certain drugs such as antiarrhythmic agents (Class IA, IC, III), psychotropic medications, antidepressants, antihistamines, and electrolyte disturbances.


After an initial excellent response, each patient relapsed and developed a severe chronic depression that was refractory to other treatments.


The first patient was treated with an intravenous phosphorus infusion.


Each treatment lasted 2-5 minutes.


A careful risk-benefit analysis is mandatory in patients with abnormal collateral vessels.


The ability of clozapine to suppress tardive dyskinesia symptoms raises the possibility that clozapine, at least at the doses used in this report, might also induce the disorder.


The average time of presentation was 17 days after LASIK (range, 7-34).


In one instance a systemic hypoglycemic reaction resulting in head trauma and confusion ended in an emegency hospital admission following the substitution of acetohexamide for acetazolamide.


Cryptococcosis is a disseminated fungal disease typically associated with immunosuppression and characterized by high mortality rates.


Clinical and radiological improvements were achieved after treatment with corticosteroid and tamoxifen.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


CONCLUSIONS: This review identifies a specific problem that can occur with central line removal.


PDT was performed twice, but after the second cycle, patient developed choroidal ischemia and the visual outcomes were poor.


BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.


Fondaparinux and bivalirudin can also be used, but they have a lower level of evidence (evidence level B).


While a causal relationship with haematological malignancies cannot be demonstrated, long-term follow-up among healthy individuals who receive haematopoietic growth factors is needed.


He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy.


Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma.


Chemotherapy followed by peripheral blood cell autotransplantation led to complete disappearance of the pancreatic and mediastinal masses.


The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.


Modulation of both dopamine and histamine systems together appears to be important in the treatment of AHC and further investigation of such pharmacotherapies is suggested.


The improvement in initiative and social capacity was striking and appeared to be due to improved awareness of the environment and the acquisition and handling of useful knowledge.


Psoriasiform eruption induced by anticonvulsants.


When the patient discontinued taking the drugs by herself because of subsiding of these symptoms, severe panic anxiety appeared.


We report a case of vitiligo that occurred during the second month of interferon alpha 2a therapy for chronic active hepatitis C.


Energy dispersive X-ray microanalysis (EDXA) confirmed that many of the granules contained silver.


Ovarian torsion: a complication of GIFT.


In the absence of palpable cysticerci, the clinical diagnosis can be missed, although no other disease in its full form presents in this manner.


Although the immediate postoperative course was uncomplicated, delayed onset of abdominal pain and fever lead to the diagnosis of superior mesenteric and portal vein thrombosis.


We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.


Severe heparin associated thrombocytopenia is a rare complication of heparin therapy.


Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.


Spinal cord tolerance is currently accepted as about 50 Gy in 1.8-2 Gy fractions.


Few have been described after liver transplantation.


Psoriasis, razoxane and a cutaneous B-cell lymphoma.


We present a report of MRI and proton MR spectroscopy (MRS) findings in an adolescent patient with Down syndrome and Crohn disease treated with metronidazole.


Maternal immunosuppression and cytomegalovirus infection of the fetus.


The results of this pilot study demonstrate that fluoxetine safely and effectively suppresses cataplexy and reduces the need for other, less desirable, anticataplectic agents.


Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.


OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.


Diagnostic and interventional percutaneous coronary catheterization is associated with stroke.


A low initial dosage that is gradually adjusted upward is recommended.


Infections and immunosuppression as specific problems in a HIV + patient transplanted for end-stage alcoholic cirrhosis.


Our experience with surgical management is reported (39 mitral and 5 aortic prosthetic thrombosis from 1982 to 1999 among 89 patients with prosthetic malfunction).


Rhomboidal, dark violet Kayexalate crystals were observed on microscope examination in the submucosa in both the first and second colonic biopsy specimens.


After gastric-outlet obstruction was recognized in several infants who received prostaglandin E1, we studied the association between the drug and this complication.


Her daily dose was 600 mg (or 12 mg/kg of body weight/day) of hydroxychloroquine.


The temporal course of CNV, the presence of a chorio-retinal shunt, and the autofluorescence pattern in the fellow eye let us to speculate that the CNV was related to the vascular occlusive process.


Although Helicobacter pylori is thought to be a predisposing factor, we found no histological evidence of this infection in our patient.


At post-mortem there was minimal leukaemic infiltration but there were alterations in the liver architecture sufficient to explain the portal hypertension.


Although drug-induced allergic nephritis (DIAN) is one of the most common problems seen by nephrologists, its true frequency is probably underestimated.


BACKGROUND: There are many reports on the complications that occur at the time of insertion and during the life of central venous indwelling catheters.


This may be related to the dose and duration of therapy with these agents.


Use of these combinations should be closely monitored.


The clinical course suggests that caffeine, which is present in oolong tea, was mainly responsible for the rhabdomyolysis as well as the delirium, although severe hyponatremia has been reported to cause rhabdomyolysis on rare occasions.


His symptoms of brain stem compression were alleviated and the role of phenytoin in the production of his craniocervical abnormality is discussed.


The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.


These instances have led to a recent warning letter to physicians and a change in the prescription labeling of tegaserod.


Successful application of permanent rapid atrial pacing requires (1) prescreening of patients with temporary external rapid atrial pacing to verify susceptibility to conversion of supraventricular tachycardia and absence of anomalous conduction pathways that may permit conduction of rapid pacing rates to the ventricles, and (2) assessment of the patient's ability to use the transmitter properly.


This prompted the patient to discontinue all herbal supplements with the subsequent resolution of his lightheadedness and orthostasis.


Aminophylline hypersensitivity apparently due to ethylenediamine.


In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.