CASE SUMMARY: A 25-year-old postpartum white woman developed multiple watery stools and abdominal cramping on day 6 of therapy with clindamycin vaginal cream for bacterial vaginosis.


Repeated exposure and rechallenge of the subject to sulindac was deemed too dangerous, and precludes exact method to establish mechanisms to explain this transient, reproducible, idiosyncratic, adverse drug reaction.


Treatment with protease inhibitors in some persons infected with HIV-1 is associated with a syndrome of lipodystrophy manifesting as peripheral lipoatrophy, relative central adiposity, insulin resistance, and serum lipid abnormalities.


Treatment with CPH 82, a mixture of two benzylidated podophyllotoxin glycosides, has been shown to improve inflammatory activity in patients with RA.


Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.


Poorly controlled hypertension in a painter with chronic lead toxicity.


After oral L-thyroxine treatment the goiter disappeared.


Mechanism of topiramate-induced acute-onset myopia and angle closure glaucoma.


Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.


IFN-alpha therapy was suspended and a treatment with l-T4 started.


In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.


Lately these episodes were followed by brief spell of unconsciousness.


DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.


Four cases suggesting that a reduction in the daily dose or withdrawal of an antidepressant may produce symptoms of major depression within hours to days are presented.


There are several known or suspected predisposing factors.


Steroid induced avascular necrosis of bones in eighteen sites: a case report.


A case report.


A 37-year-old Japanese woman received an anticancer drug for 5 years following resection of mammary cancer and then developed widespread mollusca contagiosa, which we considered to be caused by immunosuppression induced by the chemotherapy.


Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.


However, a recent post-marketing survey in Japan revealed that interstitial pneumonia occurred in 4 among approximately 2 000 Japanese patients treated with sorafenib.


We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.


It is activated by cytochrome P450 to form reactive metabolites that bind covalently to DNA to create adducts.


Upbeating nystagmus resulting from anticonvulsant intoxication.


Following several of these courses of therapy, respiratory distress occurred 9 to 12 days after the chlorambucil was given.


Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.


Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.


In the second patient an early diagnosis was made and treatment promptly instituted.


CONCLUSIONS: The results of this self-selected case series must be interpreted with caution.


A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.


Similar cases were previously described associated with captopril treatment, but not with enalapril.


The observations made in these three patients may give support to the hypothesis that cholinergic activity has pathogenic significance in depressive syndromes.


Enoxaparin therapy was discontinued, and the patient was maintained on oral warfarin.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


Several plasma and urine samples from the final stage before and during peritoneal dialysis were analyzed by GC/MS.


Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.


Prompt resolution of her jaundice followed the initiation of methionine therapy.


Mucin-producing adenocarcinoma has been extensively studied in relation to this phenomenon.


Despite of the administration of intensive therapies, she died of disseminated intravascular coagulation (DIC) and septic shock due to bone marrow depression 6 days after admission.


Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.


INTERVENTIONS: Treatment with aspirin and prednisone in one patient.


The experience obtained from the medical management of these patients is valuable for the treatment of such patients in the future.


The same test were negative in five control patients.


RESULTS: In total, 22 patients were treated with a combination of raltitrexed 3 mg/m2 every 3 weeks and mitomycin-C 7 mg/m2 every 6 weeks for up to 24 weeks.


Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.


To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.


Early peritoneal dialysis has not previously been reported for lisinopril induced multiorgan failure.


PURPOSE: This paper reviews five newly diagnosed cases of DM type 1 in Israeli Air Force aviators that presented over the last 15 yr.


She also took nifedipine, atenolol, clonidine, prednisone, aspirin, and potassium chloride throughout pregnancy.


We report a case of intrauterine contraceptive device (IUD) associated pelvic actinomycosis due to Actinomyces urogenitalis in a previously healthy young adult woman.


All patients had symptomatic hypocalcaemia, including a tonic-clonic seizure and tachyarrhythmia in one case.


RMT and AMT were lower, MEP size was larger, ICI was decreased while ICF was slightly diminished during treatment.


BACKGROUND: Cytomegalovirus (CMV) infection is a common cause of morbidity and mortality among patients receiving chronic maintenance immunosuppression and is often considered the most important infection in renal transplantation.


Hypersensitivity to this agent appears to develop after frequent exposure such as with the once-weekly regimens often used to treat brain tumors in pediatric patients.


We describe a case of endocarditis due to Lactococcus cremoris associated with cheese consumption, that caused multiple mycotic aneurysms.


The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.


Six patients presented with clinical, biochemical and histological evidence of severe hepatitis after taking herbal remedies.


We describe an 82-year-old woman treated with the fluoroquinolone, moxifloxacin, during a course of ECT.


RESULTS: A 9-year-old male who underwent orthokeratology treatment for 6 months suffered from a corneal ulcer.


The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.


The use of felbamate in patients with periodic lateralized epileptiform discharges (PLEDs).


She was treated with acyclovir and subsequently developed VZV antigen-positive zoster.


This brief period of patient education is time well spent--it will help maintain proper compliance and allay the upset that many of your patients may have if they encounter negative opinions about lindane in  the lay and medical press or from other health professionals.


DESIGN: Case report.


She had been on an immunosuppressive regimen for the past 8 years including steroids and Azathioprine.


Large cerebral infarction during praziquantel therapy in neurocysticercosis.


Data obtained from animal studies support the established hypothesis that lactate is distributed like other weak organic acids at steady-state; hence, alkalemia should favor a shift of lactate from the intracellular fluid (ICF) to the extracellular fluid (ECF).


However, significant changes in vital signs (hyper- and hypotension) and cardiac conduction abnormalities were observed in a few patients, notably in elderly patients.


Her serum total cholesterol was 515 mg/dl and triglyceride was 3378 mg/dl despite administration of 10 mg of simvastatin daily.


This case demonstrates that itraconazole may be effective treatment for dermatophytosis, even in immunocompromised hosts, and that there is no cross-reactivity between ketoconazole and itraconazole.


Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.


We evaluated fluoxetine in six patients with poorly controlled cataplexy by beginning patients on a single 20 mg dose without any change in their current medications.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


Acute myocardial necrosis during administration of amsacrine.


Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.


The etiology of acute liver dysfunction was unknown, however, we believe that the combination of oral glucocorticoid and lispro insulin was suitable and useful for preventing recurrent liver dysfunction in this patient.


High-resolution CT (HRCT) findings of this disease were compared with the pathology.


Gallstones and bile sludge are common side effects of octreotide therapy but rarely become symptomatic or require treatment.


Oxcarbazepine-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).


Transurethral resection of the mass revealed a leiomyosarcoma.


CASE SUMMARY: We report a case of scleroderma with DIHS associated with paramyxovirus infection.


These results indicate that rEpo may benefit some patients with MDS and AA who are dependent on red cell transfusions while further studies will be necessary to elucidate the mechanism by which rEpo stimulates erythropoiesis and improves anemia in patients with these diseases.


We report the confocal microscopic findings in a case of interlamellar stromal keratopathy induced by elevated intraocular pressure (IOP) after laser in situ keratomileusis (LASIK).


Thus, the value of close monitoring and when, if ever, it is safe to stop such monitoring are currently unclear.


The diagnosis of acute myocarditis with an eosinophilic infiltrate was established as the cause of death.


METHODS: [1] Trachea specimens excised from 15 healthy ferrets were incubated in culture plates lined with 200 mg of VVR, and the mucin secretion was compared to those from controls without VVR.


Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.


Upon admission, the patient's vital signs were found to be within normal limits, as were his liver profile results, complete blood count, thyroid-stimulating-hormone level, and serum chemistry panel.


We suggest that a combination of anti-TNF-alpha, plasmapheresis and high-dose intravenous gammaglobulin may be a safe and effective therapy for pregnant patients suffering severe lupus nephritis.


Here we report the case of a 43-year-old Japanese woman with acute myelogenous leukemia who underwent 2 unrelated cord blood transplantations (UCBT), terminating in fatal disseminated tuberculosis (TB).


In rats, prophylactic lithium administration inhibits reserpine-induced dopamine depletion in the brain.


All of the patients manifested an increase in serum CK levels 1 to 3 months after the administration of antithyroid drugs.


No benefit has been shown from adding bivalirudin to a GP IIb/ IIIa inhibitor.


CONCLUSION: Catheter failure is a common cause of intrathecal drug delivery problems and may be difficult to diagnose.


A patient presented with a painful, oedematous, cyanosed hand having injected a solution of diamorphine and methylphenidate into his radial artery.


Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.


Possible mechanisms of esophageal spasm and its relief with glucagon are discussed.


Iatrogenic ergotism is the primary source of ergot intoxication.


BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.


A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy.


Cutaneous ulceration: an unusual complication of intravenous pentamidine therapy.


Food and Drug Administration in 1989 for treatment of severely ill schizophrenic patients.


Our patient was a 32-year-old man who tested positive for HCV in July 1997.


The patient was placed on ethacrynic acid until she was desensitized to furosemide.


The anterior mediastinum was closed with an omental flap that was allowed to epithelize spontaneously.


7. The vast majority of patients reported in the literature with ANLL complicating underlying malignancies have received cytotoxic drugs for prolonged periods (median 3 1/2 years) and leukemia developed most commonly 3 to 5 years after the diagnosis of the underlying disease.


A case of recurrent impetigo herpetiformis with a positive family history.


Both renal allografts had to be removed because of renal artery rupture secondary to Candida albicans infection.


Ethambutol is frequently used in the treatment of tuberculosis, and, although optic neuropathies have been reported with the use of ethambutol, this adverse side effect has been considered to be rare and generally reversible with discontinuation of the medication.


The combined occurrence of bronchial anthracostenosis and mediastinal fibrosis in association with wood-smoke exposure has not been previously reported.


Cryptococcus neoformans has been reported to be isolated from blood cultures in around 20% of patients with cryptococcosis, and cryptococcemia has been correlated with poor prognosis.


The present patient was diagnosed with congenitally corrected transposition of the great arteries (cc-TGA) and underwent systemic atrioventricular valve replacement for severe insufficiency at 23 years of age.


In this article the possibility of using the Minirin (desmopressin) in maxillofacial surgery in person with hemostatic disorders has been described.


Angioedema and maculopapular eruptions associated with carbamazepine administration.


PEComas demonstrated loss of TSC2 protein expression and evidence of baseline mTORC1 activation.


One patient had partial responses in both treated tumors.


A 15-year-old boy had temporary hypertropia, supraduction deficit, ipsilateral mydriasis, and accommodative paresis after bilateral endoscopic ethmoidectomy, bilateral partial inferior turbinectomy, septoplasty, and Caldwell-Luc procedures for chronic sinusitis.


The increased libido disappeared after fluvoxamine was discontinued.


Four patients did not receive MB and all recovered only after 48 h.


This is the first series of cases to be reported demonstrating the potentially blinding complications of topical facial steroids.


Between March and May 1996, the patient was admitted several times to a neurology clinic, where myasthenia gravis was diagnosed and treatment with pyridostigmine and cyclosporine was initiated.


Carbamazepine-induced Diabetes mellitus.


Widespread cutaneous vasculitis associated with diltiazem.


After stopping isoniazid, his breast swelling subsided to some extent and became non-tender.


Indium-111-labeled-leukocyte scintigraphy was performed on three febrile patients, two of whom had no signs or symptoms referable to the respiratory tract.


In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.


METHOD: Demonstration of the occurrence of agitated dysphoria after loss of response to an antidepressant following continuous administration through 7 years of euthymia; with a worsening on dose increase; and recurrence of agitation on re-exposure 1 year later; in a patient whose previous dysthymia and recurrent depressions had no recognizable manic or hypomanic features.


Cerebral vasospasm on MR angiography (MRA) has been noted in cases due to eclampsia.


Fifteen shots of 0.06 mJ were needed.


The total number of nucleated cells infused was 0.8 x 108/kg, with CD34+ cells 1.8 x 106/kg and CFU-GM 1 x 104/kg.


Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.


METHODS: Case report.


Aquagenic syringeal acrokeratoderma.


RESULTS: A woman with a >15-year history of ovarian cancer experienced severe neurotoxicity (peripheral neuropathy, hearing loss), underwent aggressive resection of asymptomatic and long-standing metastatic disease in the liver (with tumor recurrence <1 year after surgery), and subsequently died of secondary acute leukemia.


However, he developed significant bradycardia.


When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.


The calculated median cumulative dose of gemcitabine was 20,000 mg/m(2) (range, 2,450 to 48,000 mg/m(2), or a total of 70,000 mg).


A drug lymphocyte stimulation test was positive only for calcium stearate, an additive contained in the homochlorcyclizine hydrochloride tablet.


Oculogyric crisis is a neurologic reaction characterized by bilateral dystonic elevation of visual gaze as well as hyperextension of the neck.


OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.


RESULTS: A 44-year-old man taking naproxen for chronic low back pain and a 20-year-old woman on oxaprozin for rheumatoid arthritis presented with tense bullae and cutaneous fragility on the face and the back of the hands.


Immunosuppression could disseminate tuberculous focuses, resulting in extracervical involvement of SD connected with the underlying extrapulmonary tuberculous lesions.


DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.


We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.


Immunosuppressive treatment of rippling muscles in patients with myasthenia gravis.


Usually, these patients develop hepatitis B surface antigen (HBsAg) seroreversion during the flare.


A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.


Post-transplant lymphoproliferative disorder following cytomegalovirus reactivation in a lung recipient.


The subjects were confined to female patients to exclude patients with potential prostate hypertrophy.


Splenic hemorrhage: a complication of tissue plasminogen activator treatment.


Ruptured Meckel diverticulum mimicking mucositis in a patient receiving induction therapy for high-risk acute lymphoblastic leukemia.


Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen.


The present case is the first report of hypercalcemia induced by vitamin D3 ointment and thiazide simultaneously.


We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney.


The catheter was removed and the abscess was drained.


A 48-year-old woman with known epilepsy presented to the Emergency Department with a 1-day history of decreasing coordination, impaired speech, and recurrent falls.


The clinical symptoms of gastric mucosa foveolar hyperplasia due to long-term PGE1 therapy simulate hypertrophic pyloric stenosis.


We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.


Although not typical, this result was suspicious of tumor seeding, the more since the lesions appeared in gray matter areas outside the high-dose-rate irradiation field.


CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.


Smoke inhalation injury from newer synthetic building materials--a patient who survived 205 days.


Patients were followed with sequential ocular examinations for a maximum of 36 weeks.


Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.


RSV was the only infectious agent that could be isolated, and treatment with aerosolized ribavirin lead to prompt improvement of all symptoms.


After cessation of chemotherapy, the pulmonary lesions resolved and all three patients sustained their remissions.


Alopecia is a rare but important side effect of anti-parkinsonian medications.


We describe the case of a man with dermatomyositis and stage IV nasopharyngeal cancer treated with chemoradiotherapy and s.c. amifostine.


Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.


To our knowledge, this is the second report of HSOS after standard dose chemotherapy for brain tumor in childhood.


Fournier's gangrene complicating aggressive therapy for hematologic malignancy.


Postmortem examination revealed white matter vacuolation in the brain stem tegmentum and cerebellar hemispheres similar to that seen in toxicity from hexachlorophene, to which our patient was not exposed.


Polymicrobial sepsis is sometimes seen due to enteric organisms adhering to the parasite.


A treatment, possibly radiation-associated tumor cell alteration resulting in a different catecholamine production, is discussed.


Clinical manifestations resolved after surgical drainage of the thyroid abscess, prolonged antibiotherapy and diminution of immunosuppressive regimen.


However, many patients who should receive or be offered preventive treatment are not.


Adalimumab belongs to the group of tumour necrosis factor-alpha inhibitors and has been approved for the treatment Crohn's Disease since 2007.


Management of pericatheter cerebrospinal fluid leak after intrathecal implantation of a drug delivery system.


Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).


We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment.


Although rare, this complication may not be disregarded in the cases that require intraocular corticosteroids for treatment of several conditions, especially in patients who had previously suffered from toxoplasmosis infection.


TEN is a disease of both children and adults, but TEN in early infancy is a rare event; only two well-documented cases in infants less than 6 months of age have been reported.


All three cases demonstrate that hyperosmolar hyperglycemic nonketotic coma is a serious potential complication of systemic steroidal therapy, even in a short course of treatment such as is often used in ophthalmology.


On admission she had 2-3+ pitting edema.


A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).


Thiazide diuretic therapy and chronic photosensitivity.


The presence of lichen ruber planus and GH insufficiency probably secondary to empty sella are two unusual findings in patients with APECED.


Sunburn may sometimes be a major injury in psoralen users because high doses or inappropriate use of the drug may render the skin extremely sensitive.


Glatiramer acetate (copolymer 1, Copaxone) is a mixture of synthetic polypeptides and is used for the treatment of multiple sclerosis.


Bleomycin pneumonitis potentiated by oxygen administration.


Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.


An evaluation of ovarian structure and function should be considered in women of reproductive age being treated with valproate for epilepsy, especially if they develop menstrual cycle disturbances during treatment.


This is the first reported use of high-dose-rate remote brachytherapy (HDR) to treat RMS in young children.


The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.


Cerebrovascular complications were the most frequent and were seen in 51% of the liver, 59% of the heart, 58% of the lung, 50% of the heart-lung, 49% of the kidney and 44% of the bone marrow allografts.


After recovery CT scan follow-up showed marked cerebral atrophy which did not exist prior to the state of coma.


He was given adriamycin 50 mg/m2 and cyclophosphamide 350 mg/m2 for 6 days followed by 4 days of vincristine 1 mg/m2 and bleomycin 10 mg/m2.


We review similar reported cases and discuss the direct actions of glucocorticoids on the brain.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


Mutations were detected in the precore region (nt1896) of HBV.


CASE SUMMARY: A febrile 36-year-old seaman from Mumbai (Bombay) was prescribed >5 times the usual dose of chloroquine for malaria diagnosed empirically onboard ship.


Even though AZ tends to strongly bind to plasma protein and its clearance is generally poor by hemodialysis (HD), in our patient, HD was observed to be rather effective since the clearance of AZ was 45.8 ml/min on HD and 66 ml/min on direct hemoperfusion (DHP).


Other causes of acute hepatocellular necrosis were excluded.


This is a case report of fatal cryptococcal meningitis in a child with systemic lupus erythematosus being treated with prednisolone and azathioprine.


A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.


The patients were followed up for an average of 32 months (range 16-75 months).


This paper presents 3 sisters with Gitelman syndrome who could not tolerate magnesium supplements, and whose hypotension and polyuria were eliminated by taking 2 mg/kg/day indometacin, but who grew poorly.


Putative drug-related pemphigus foliaceus in four dogs.


Use of recombinant human hemopoietic colony-stimulating factor was reported to be of benefit in patients who developed agranulocytosis, although there is still some doubt regarding the efficacy in AA.


Case report.


She had been treated before with other antipsychotic drugs.


All-trans retinoic acid (ATRA) has been used successfully in inducing remission in patients with acute promyelocytic leukemia (APL).


The skin lesions disappeared almost completely within three months.


This is the first reported case of CNS excitatory toxicities in a patient with alcoholic hepatitis and cirrhosis, and normal renal function.


The mechanism of the interaction is probably inhibition of glipizide metabolism rather than protein-binding displacement.


Severe slowly resolving heroin-induced pulmonary edema.


A 60 year-old woman with chronic renal failure developed acute proximal muscle weakness after receiving a regular dosage of colchicine.


Brain biopsy in all three disclosed PML and marked perivascular lymphoplasmacytic infiltration.


Successful treatment of invasive aspergillosis complicating prolonged treatment-related neutropenia in acute myelogenous leukemia with amphotericin B lipid complex.


METHODS: Switching of agents took place in two ways: converting only antipsychotic medications followed by other psychotropics, and changing all psychotropics simultaneously.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


An oral glucose tolerance test showed impaired glucose tolerance with marked insulin resistance.


An alternative preparation, Mastisol, was successfully used without primarily inducing allergy.


Pancreatic autoantibody tests were negative before the start of therapy, but a significant increase in glutamic acid decarboxylase (GAD) antibody titer was seen after 24 weeks of treatment.


The subsequent clinical course was unremarkable until postoperative day 146, when a deep stromal infiltrate was present at the graft-host junction, associated with a dense endothelial plaque.


Magnetic resonance imaging brain showed features of posterior reversible encephalopathy syndrome, a recognised but rare complication of hypertension in children.


Risks and benefits should be seriously considered before starting treatment.


EEG was abnormal and somatosensory-evoked potentials (SEPs) showed giant SEPs, transcortical reflex (C reflex) and jerk locked potentials.


One patient died of a self-inflicted gunshot wound.


During these episodes she was lost in herself.


A clinical case of Cheyletiella infestation on a dog born and raised in Korea is reported.


A patient with severe cholestatic jaundice induced by captopril is presented.


Steroids are used extensively in modern medicine and dentistry for their anti-inflammatory and immunosuppressive properties.


ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.


Continuous PGE1 administration ensures patency of the ductus arteriosus, which is essential for stabilizing the general condition until cardiac surgery can be performed.


However, both patients had abnormally large epidural fat deposits as an underlying and contributing condition.


Serum sickness consists of a systemic reaction resulting from the formation of soluble circulating immunocomplexes after the introduction of a foreign substance into the body We studied a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis who was treated with phenylbutazone, ranitidine, clomipramine and levomepromazine.


Six of 13 outpatients with schizophrenia who participated in a ten-week open trial of risperidone had an initial good response to the medication followed by development of intolerable affect, including feelings of agitation and depression and periods of crying and insomnia.


We describe three HIV-infected patients who were given MTX for severe psoriatic arthritis.


His muscle symptoms were involved in four limbs and tongue, and deep tendon reflexes were exaggerated.


In order to investigate the mechanism of late asthmatic response (LAR), inhibitory effects of various drugs for LAR were examined in two wheat flour-sensitive asthmatic subjects who showed immediate and late responses in the allergen provocation test and skin test.


After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.


We describe a case of pneumonitis following local administration of methotrexate for nonsurgical termination of an ectopic pregnancy.


During 6 weeks of monitoring, arrhythmia did not recur.


Radiation recall refers to inflammatory reactions triggered by cytotoxic agents and develops in previously irradiated areas.


Regarded as the most common and best understood of the hereditary periodic fever syndromes, familial Mediterranean fever (FMF) is a recessively inherited disease of episodic fever with some combination of severe abdominal pain, pleurisy, arthritis, and a characteristic ankle rash.


To our knowledge no severe persistent neurological deficits following thrombolytic therapy have been reported.


Cerebrospinal fluid analysis was consistent with syphilitic meningitis.


Two weeks later, he died of fungal septicemia and multiorgan failure.


The following is a case report analysis intended to draw attention to the need for better care coordination by describing the observed relationship of olanzapine to metabolic changes manifested as uncontrolled diabetes mellitus and weight gain.


Furthermore, each patient was subsequently treated with other antihypertensive medications which, like propranolol, contain the stabilizer additive tartrazine.


The patient became afebrile after 48 h, and his general condition improved within 36 h.


It is strongly recommended that heparin be substituted with another anticoagulant in such cases until the presence of HDAs can be definitively ruled out.


However, it is possible that the previous antipsychotic exposure could have created a sensitising or priming effect on the striatum.


A case is described in which viscoelastic material was used in the anterior chamber to minimize or prevent fluid flow through the area of the trabecular meshwork and Schlemm's canal during nonpenetrating filtering surgery.


OBJECTIVE: To report 2 cases of nonconvulsive status epilepticus (NCSE) following infusion of ifosfamide.


This report may aid in the decision of imatinib being given under close surveillance to this kind of patients.


Fluctuating QTc interval in an asymptomatic patient treated with methadone for chronic pain.


In May 1999, the patient came to our polyclinic with edema of the feet and legs.


The multifactorial pathogenesis of ARF includes (a) a disturbance of glomerular microcirculation (afferent and perhaps mesangial constriction, inadequate efferent dilatation); (b) a disturbance of medullary microcirculation (medullary capillary congestion) attributed to a combination of endothelial damage and tubular dilatation; (c) tubular cell damage which, though rarely in humans justifying the term 'acute tubular necrosis', promotes both backleak of glomerular filtrate and shedding of brush border vesicles; (d) the latter promotes tubular obstruction by casts which consist of Tamm-Horsfall protein and brush border components.


They both are weak systemic diuretics and lower intraocular pressure ultimately by decreasing aqueous production.


After 18 months, the patient was in good health.


Yohimbine is a selective alpha-2 adrenergic antagonist that has been used in the pharmacologic management of erectile dysfunction (ED).


Totally implantable venous device (TIVD) are widely used for the treatment of patients requiring long-term chemotherapy, total parenteral nutrition and fluid replacement.


There is currently no consensus on the best treatment for unresectable hyaline-vascular variant or for multicentric Castleman's disease (MCD), because none of the reported regimens have consistently produced complete response or durable remission in the majority of patients In the present study, we report on the use of 2-CdA (2-chloro-deoxyadenosine) in three patients, two of them with MCD and one with unresectable hyaline-vascular type disease.


We conclude that prolonged l-asparaginase therapy in combination with an anthracycline might well be used in initial or consolidation therapy for childhood ALL.


This report describes a forty-seven-year-old female patient with a complex medical history.


CASE SUMMARIES: Two patients with stable hypothyroidism experienced symptoms of hypothyroidism with increased serum thyroid-stimulating hormone (TSH) concentrations after switching from 1 levothyroxine product to another.


In two cases, tiagabine was withdrawn, whereas it was continued at a lower dosage in one case.


In each instance the ST segment returned to the isoelectric line within 24 hours, and subsequent development of Q waves or changes in the QRS was not observed.


High-dose intravenous mannitol infusion in various clinical settings may result in acute renal failure (ARF).


A 55-year-old man is reported who initially developed chronic lymphocytic leukemia.


A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis.


Plasmapheresis and immunosuppressive therapy.


This pathology should be treated promptly and with specific therapy to avoid progression to a severe, massive PTE.


Two and a half hours after intravenous infusion of the antibody fragments, the signs of intoxication passed off, and atrial fibrillation with a normal ventricular rate was reinstated.


Thrombosis of central venous access catheters was demonstrated in two neonates born at 38 and 27 weeks' gestation.


Also, it may uncover underlying atrial arrhythmias by slowing the ventricular response.


Three PC lines broke at the time of removal resulting in a length of line remaining in the central venous system (the superior vena cava, innominate vein, and bracheo-cephalic subclavian junction).


All patients improved rapidly after discontinuation of 5-ASA compounds.


In this patient a single plasma exchange was successful in considerably lowering the plasma dextran concentration.


The mortality rate has been estimated at about 10%.


We report on a case of secondary myelodysplasia with basophilia.


The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.


Endogenous thrombopoietin serum levels during multicycle chemotherapy.


This case showed a remarkable granulomatous reaction in association with tumor elimination.


The patient recovered completely clinically and radiologically after discontinuing cyclosporine.


We describe a 41 yr old leprosy patient treated for 10 yrs with clofazimine who underwent laparotomy for severe abdominal pain.


It is concluded that treatment with hCG/LH may favour seizure onset in the presence of potentially epileptogenic lesions such as an intracranial dermoid cyst.


Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.


The use of combined therapy with an angiotensin-converting enzyme (ACE) inhibitor and an angiotensin II receptor blocker (ARB) for treatment of proteinuria has been gaining support.


This finding suggests that cytomegalovirus infection may be one of the causes or exacerbating factors for ileal ulcers in Churg-Strauss syndrome, although ulcers of the intestine have usually been considered to be caused by ischemia resulting from angiitis.


A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.


All other factors, including laboratory data, dietary intake, activity level, and concurrent use of other medications, were stable and noncontributory.


This demonstrates that, despite the normal coagulation profiles previously described, mothers on chronic anticonvulsant therapy may have a subclinical carboxylation defect, while their infants are at risk for hemorrhagic disease.


Of the five patients, two had a marked response in total Hb in excess of 3 g/dl, two responded modestly with an increase in total Hb of 1-2 g/dl, and one did not respond.


Heparin was discontinued, and an argatroban infusion was initiated.


Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.


Second malignancy is one of the late complications of long-term cancer survivors, treated with radiation or chemotherapy.


We describe a 65-year-old man with HIV who underwent a 12-hour intensive pharmacokinetic study while receiving esomeprazole with atazanavir-ritonavir and subsequently, an 8-hour study while receiving esomeprazole with fosamprenavir-ritonavir.


This is the first reported case of the use of Monsel's solution to arrest excessive uterine bleeding after the evacuation of retained products of conception after a miscarriage.


We report on a case associated with atenolol.


Despite a complete molecular response, it is currently recommended to continue these targeted therapies to avoid relapse.


Three weeks later, he developed an abrupt elevation of blood pressure (210/120 mmHg), with headaches, mental confusion, and generalized seizures.


Our patient presents one copy of the most common mutation (CYP2C19*2) affecting the activity of the isoenzyme and probably another rare or private mutation.


CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment.


This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.


A primigravid woman presented at 11 weeks gestation with bilateral femoral occlusive thrombi extending above the renal veins.


The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.


In addition to reporting this case, we review the literature regarding enteroviral infections after transplantation.


Drug interactions and neutralizations as well as dietary factors contributed to a complicated course.


Exceptionally long absence status: multifactorial etiology, drug interactions and complications.


Apomorphine-induced penile erections in Parkinson's disease.


A retrospective analysis was performed to determine the incidence and clinical features of acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) developing in chronic lymphocytic leukemia (CLL) patients.


Each patient was taking more than 200 mg of oral morphine equivalents per day, and several were receiving complex analgesic regimens consisting of multiple adjuvant medications.


INVESTIGATIONS: Echocardiogram, electrocardiogram, serum chemistries, coronary angiography, right-heart and left-heart catheterization and endomyocardial biopsy.


Four patients with an intermittent psychosis closely resembling hallucinogenic drug-induced states were suspected of having a porphyric disease and were investigated for a possible relation between the metabolic dysfunctions of porphyria and the psychotic syndrome.


This particular form of hyperthyroidism is long-lasting because of the slow elimination of amiodarone.


The most common complaint was headache.


Those findings are indicators of colitis.


While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.


More attention should be focused on long term effects of neuroleptics.


If unrecognized, the neurologic deterioration becomes irreversible and may result in death.


To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.


The patient was urged to discontinue her use of deodorants.


This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.


Asthma and urticaria during disodium cromoglycate treatment.


Combination therapy with i.a. urokinase, i.a. prostaglandines and i.v. anticoagulation resulted in re-opening of the obstructed distal artery and complete cessation of symptoms.


Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.


5: Movement disorders I: parkinsonism and the akinetic-rigid syndromes.


CLS is seen in conditions such as septic shock or may result from conditions such as multitrauma and pancreatitis, which result in the systemic inflammatory response syndrome (SIRS).


However, a direct association between corticosteroid use and osteonecrosis has never been proven.


S-1 is an oral 5-fluorouracil (5-FU) anticancer agent and has shown promising effects in the treatment of a wide range of carcinomas, including head and neck cancer.


Warfarin-associated thoracic aortic dissection in an elderly woman.


The patient was discharged after 110 days.


We suggest that lamivudine is indicated both in the treatment of HBV viremia and in the prevention of proliferation of HBV in patients with HBV carrier status undergoing high-dose myeloablative chemotherapy.


CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.


Percutaneous coronary intervention (PCI) is routinely performed in patients with non-ST elevation acute coronary syndromes after pretreatment with clopidogrel and periprocedural administration of unfractionated heparin on a weight-adjusted basis.


A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.


Surveillance strategies and significance of endometrial cells on the Pap smear are reviewed.


Monitoring of the long-term safety profile of TKIs is essential due to the prolonged survival of these patients.


Maintenance dosages controlled the condition thereafter.


Therefore, an alternative therapy is necessary, especially for patients who need to continue permanent administration of the drug.


One patient died of cardiac arrest at 25 months; there were no perioperative deaths (< or = 30 days).


In one case the growth rate and cortisol response returned to normal 9 months after the fluticasone dose was reduced to 500 micrograms/day.


Catheterization of the right side of the heart (Swan-Ganz catheter) was a technology that became widely used before any outcome studies became available.


Ciprofloxacin-induced renal insufficiency in cystic fibrosis.


Aggressive antibiotic management and attainment of complete remission of his leukemia resulted in a successful outcome.


Hypercalcemia in a renal transplant recipient suffering with Pneumocystis carinii pneumonia.


A successful cord blood transplant in a child with second accelerated phase chronic myeloid leukemia following lymphoid blast crisis.


CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.


After a follow-up of more than 2 1/2 years no significant recovery was seen in these cases.


Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.


Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios less than 20, urinary sodium concentrations 16 to 60 mEq/liter, proteinuria, and cylindruria.


In this report, we demonstrate the fluoroquinolone class of antibiotics can be associated with prolonged electroconvulsive seizure duration.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.


The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.


Odontogenic cell sensitivity is dependent upon the position on the cell cycle and the mitotic activity at the time of chemoradiation therapy.


In addition, his overall medical status worsened, as he developed concurrent acute renal failure and became more confused and lethargic.


Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.


Role of a long-acting somatostatin analogue (SMS 201-995) in the treatment of acromegaly.


Pregnancy and complicated familial Mediterranean fever.


Griseofulvin may be associated with an increased incidence of adverse cutaneous reactions in patients with systemic lupus erythematosus.


TREATMENT/OUTCOME: Standard anti-tuberculosis therapy was administered but was complicated by interaction with cyclosporine and drug-induced cholestasis.


Thioamide therapy has improved the outcome of pregnancies complicated by maternal hyperthyroidism, without long-term effects on cognitive and somatic development.


Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol.


This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.


Neutropenic enterocolitis (NE) is a severe gastrointestinal complication in patients who undergo aggressive chemotherapy.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


Multifocal disseminated lesions of circumscribed lipoatrophy have not been described as an adverse reaction of intravenously applied drugs.


After the patient discontinued rifampicin, the skin lesions cleared completely within 5 weeks without any systemic medication.


At operation a subarachnoid and a subdural haematoma were found, extending between the levels of the vertebrae T3 and L2.


Maternal values were 2.4 and 4%, and infant values 20.0 and 18% in cases 1 and 2, respectively.


The case of a 46-year-old woman with chronic hepatitis C who was prescribed subcutaneous pegylated interferon once a week and oral ribavirin once a day is presented.


This form of treatment is easily administered, is repeatable and free from serious complications.


This series includes a case of bilateral thrombosis of the internal and external jugular veins in the 7th gestational week in a twin pregnancy after OHSS and ICSI, with termination of the pregnancy in the 9th gestational week due to progressive thrombosis during anticoagulation therapy.


Thrombotic microangiopathy associated with chemotherapy: case report and review of the literature.


We suspect that nefazodone inhibits metabolism of tacrolimus.


Several different criteria for diagnosis exist, and each differs from the others slightly.


Cryptococcal meningitis is a life-threatening complication of this disease.


It is generally known that excessive blood levels of AZ inhibit not only the gastric juices but also prostaglandin levels and HCO3- excretion in the gastric mucosal barrier.


This undesirable side effect of Tolazoline may be prevented by the concomitant use of antacids to maintain gastric pH greater than 5.


Terbutaline is a beta2-adrenergic agonist that may mediate its effects via direct beta2-receptor stimulation, baroreceptor-mediated increases in sympathetic tone, or via presynaptic beta2-stimulation.


Seizure control was not reestablished.


Sixth day after TAC chemotherapy, she had abdominal pain and vomiting.


Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.


Examination by MRI during the clinical course clarified the presence and disappearance of an epidural abscess and diskitis.


Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane.


They should be recognized as a possible side effect of GBP treatment in adults.


The eye eventually became blind and painful and was enucleated.


We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.


The detection rates were fluoxetine, 48.8% (20/41); tricyclics, 5.8% (3/52); RBD, 4.3% (3/70); objectively normal sleepers, 3.3% (1/30); PLM, ST/SW, 0% (0/82).


Carotid angioplasty and carotid artery stenting were performed using the distal protection system with the PercuSurge GuardWire.


He died 1 month later in spite of methylprednisolone pulse therapy, large spectrum antimicrobial therapy, and full support of respiratory, hemodynamic and renal systems.


Further biopsy revealed a more severe glomerular lesion.


However, nerve block by this procedure may in very rare instances give rise to serious complications.


Engraftment occurred on day +35.


Limited data are available regarding use of direct thrombin inhibitors in patients who have severe hepatic impairment with concurrent renal failure requiring CVVHD.


He developed a low grade fever, cough and nasal discharge, and was given a compound "cold" remedy with anticholenergic properties.


CASE REPORT: A 76-year-old man came to us in October 1998 with symptoms of foreign body sensation, epiphora, and difficulty removing his contact lenses.


The donor was asymptomatic and had a negative review of systems, a normal physical exam, normal laboratory values, and negative blood and urine cultures.


The clinical syndrome was a self-limiting proteinuria with normal renal function.


Reversible leukopenia was documented in an 81-year-old woman treated with adjunctive ibopamine 100 mg t.i.d. for chronic congestive heart failure.


We describe our initial experience of HCQ slow oral desensitization.


There may be an interval of one or more months after discontinuation of cyclophosphamide therapy before clinical or radiological improvement occurs.


Diagnosis and management of such infections in the immunosuppressed host are difficult.


A 44-year-old Caucasian male who had been on long-term steroid treatment for an unspecified collagen disease was referred to our Unit because of fever, severe hypopharyngeal dysphagia, night sweats and evidence of marked superior vena cava compression.


The stenosis developed in the area of previously noted tracheal ulceration and responded satisfactorily to carbon dioxide laser therapy.


Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.


Oral hairy leukoplakia in nonimmunosuppressed patients.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


At further evaluation, HBsAg was positive but serological work up was compatible with a healthy-carrier status.


Magnesium toxicosis in two horses.


Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.


This experience supports the hypothesis that heparin can be readministered early to patients with heparin-associated thrombocytopenia and thrombosis, provided antiplatelet therapy is given.


In a single practice during the 21 years 1971-1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p < 0.001).


Symptomatology resolved with diphenhydramine.


MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.


Magnesium sulfate and digitalis-toxic arrhythmias.


Near fatal acute colchicine intoxication in a child.


Of 165 consecutive patients undergoing computerized tomography- or magnetic resonance imaging-guided stereotactic brain biopsies at the Cleveland Clinic between June, 1987, and November, 1989, four patients (2.4%) developed arterial hemorrhage refractory to conventional efforts to secure hemostasis.


Numerous studies suggest that ganciclovir has clinical efficacy against cytomegalovirus disease, as well as an in vivo antiviral effect, and that this agent reduces morbidity of serious cytomegalovirus infections in immunocompromised patients.


AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C.


His home medications at the time of presentation included propanolol 10 mg tid, haloperidol 10 mg bid, sodium valproate 500 mg bid, benztropine 1 mg bid, and haloperidol decanoate 100 mg i.m. every 3 weeks, from another psychiatric facility.


Severe neutropenia and thrombocytopenia were encountered but they were reversible and no life-threatening complications were experienced.


Epsilon-aminocaproic acid (EACA) is a potent anti-fibrinolytic agent that is used in the treatment of excessive bleeding resulting from a systemic fibrinolytic state.


This report documents that duct paucity may occur within 10 days of onset of jaundice and appears to be confined to ducts less than 0.03 mm in diameter.


Seven patients only smoked at night-time (median dose eight puffs, range two to eight puffs), and eight patients used cannabis mainly during the day (median dose three puffs, range two to eight puffs); the median frequency of use was four times per day (range one to 16 times per day).


CONCLUSIONS: Nocardiosis should be considered a potential pathogen in this immunocompromised setting.


Cerebrospinal fluid smear showed the ie, Streptococcus agalactiae that grew on blood wound culture, sent at the time of admission.


The situation is less clear regarding other anti-malarial quinine analogues.


A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.


Elevated serum triglycerides with clozapine resolved with risperidone in four patients.


Aspergillus sp. infection was the most common of all CNS infections followed by viral, bacterial and protozoal.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


Asthma and urticaria during disodium cromoglycate treatment.


After prostate irradiation, many patients experience a transient rise in serum PSA levels and a subsequent decline without any treatment.


The sixth woman, with an empty sella turcica after radiation therapy of a pituitary adenoma, had an endometrial mullerian adenosarcoma at the age of 40 years after 16 years of estrogen therapy.


Metronidazole was initiated at a dose of 500 mg orally three times daily and continued for 10 days.


Hydroxyurea-induced acute interstitial pneumonitis in a patient with essential thrombocythemia.


BACKGROUND: Cloxacillin is a semisynthetic penicillin widely used in nonmethicillin resistant Staphylococcus aureus infections.


OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.


Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.


We report an unusual case of verrucal alopecia occurring on the vertex scalp of a black woman, which was presumed to be secondary to use of a thioglycolate permanent wave preparation.


The past medical and occupational history was negative.


Current literature related to the presented case and the ongoing debate regarding repeated prescriptions are considered in this study.


The good results reported in previous series were only found in this study when the indications were restricted to certain favourable prognostic factors: duration of sciatica less than 6 months and CAT-scan appearance of discal hernia.


Two patients have been successfully tapered off tacrolimus, and 2 patients are currently on once-daily dosing.


Methadone has two roles in human immunodeficiency viral infection: pain management and treatment of opioid abuse.


Diabetes associated with atypical antipsychotic treatment may be severe but reversible: case report.


Clinical improvement occurred with cessation of the benzodiazepines and the EEG showed a return to normal patterns.


We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).


Neither patient had a history of meningioma initially and both were being treated interferon when the meningioma was progressed.


This, together with the primitive venous bed developing in the periventricular region, was associated with the spontaneous hemorrhage in the region of the foramen of Monro.


Outcome of pregnancy in women treated with all-trans retinoic acid; a case report and review of literature.


The induced pustules, as well as those appearing clinically, were intraepidermal and indistinguishable from the Kogoj spongiform abscess, and on serial sectioning showed a distinctive localization to the acryosyringium.


The patient--a 51-year-old man who was a victim of nasopharyngeal cancer--developed a complex behavioral disturbance consisting of visual agnosia, alteration of sexual behavior, strong oral tendency, placidity, memory deficit and speech disturbance one year after two courses of irradiation and chemotherapy.


Posttransplant primary cutaneous Ki-1 (CD30)+/CD56+ anaplastic large cell lymphoma.


Antimicrobial susceptibility results determined by a modified proportion method using a 3-day incubation were the same as those determined by the standard 3-week assay.


This patient and other indigent patients who may be poor compliers because they are unable to buy the necessary medication may be at a higher risk for adverse reactions.


CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.


In each case, the leukopenia was dose-dependent.


Quinine induced coagulopathy--a near fatal experience.


We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.


Infections are common comorbid conditions in hospitalized patients, including those receiving electroconvulsive therapy (ECT).


Due to an error in drug dilution the patient received a 100-fold overdose of indomethacin.


This increase was mirrored by an improvement in seizures, but not in myoclonus or ataxia.


A 77-year-old woman with type II diabetes mellitus was admitted to our hospital in August/ 1995 with severe hyperlipidemia.


A possible explanation of these data is that erythropoietin permitted the termination of blood transfusions which both triggered and perpetuated the syndrome.


If anticonvulsants are employed, then they must be administered with caution, and all cutaneous reactions developing subsequently within the radiation site must be promptly evaluated with a high index of suspicion for erythema multiforme.


Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.


The patient reported in this case differs significantly from the two cases reported in the literature because he had normal renal function, no previous exposure to ACE inhibitors, the reaction was of late onset, and the symptoms recurred.


Only the third patient showed elevated levels of MMF.


Conventional explanations of the decline in renal function with ACE inhibition do not account for irreversible decrements in renal function.


In cases with opportunistic infections, discontinuation of TNF-alpha inhibitors is a common practice, however rapid rebound of inflammatory responses may incur the risk of immune reconstitution syndrome.


We investigated initial drug-drug interactions between lamotrigine and sertraline.


METHODS AND RESULTS: The authors describe a 62-year-old man with a malignant thymoma that was clinically responsive to oral prednisone.


Acute rehabilitation refers to the multidisciplinary rehabilitative treatment of patients in continuing need of integrated acute and rehabilitative longterm care.


We report on a patient who developed acute rhabdomyolysis after taking cerivastatin.


The interrelationship between the immunosuppressive effects of neoplasia and chemotherapy with the resultant thymic overgrowth remains to be clarified.


We report the case of a 17-year-old male who developed chest pain, elevated cardiac biomarkers, and acute left ventricular dysfunction following a single dose of methylphenidate.


Anatomic arterial variation of the hand can lead to atypical presentation.


Acute renal failure (ARF) is a rare but severe complication of active idiopathic nephrotic syndrome (INS) in children.


She rapidly recovered with omission of dapsone and therapy with systemic corticosteroids and a topical emollient.


Surgery can relieve refractory tremor and dyskinesias, but does not alter disease progression or need for drug therapy.


A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.


Considerable improvement of myasthenic symptoms was seen in all patients within 3-6 months after the initiation of this therapy.


At autopsy, typical angiodestructive and angiocentric lesions with large lymphoid cells (immunoblasts) were found in the lungs and mediastinal nodes.


The success rate of the two approaches appeared to be approximately equal.


The challenge test for Stevens-Johnson syndrome type drug allergy is very risky.


Levosimendan (LS) is a novel calcium sensitizer drug that enhances cardiac contractility without increasing myocardial oxygen consumption, and induces vasodilatation.


The histopathological findings in pemphigus patients with a history of psoriasis may resemble Munro's microabscesses of psoriasis and should therefore alert pathologists and clinicians in considering additional diagnostic methods such as direct and indirect immunofluorescence.


Voriconazole (VRC) has not previously been reported to cause angio-oedema.


She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.


Therapy-related acute myeloid leukemia following HIV-associated lymphoma.


The tumor initially had responded well to chemotherapy; however, while the tumor mass decreased, plasma and urine catecholamines and the blood pressure increased.


We feel that these results may be attributed to this specific growth factor combination, including ancestim, a cytokine known to act on primitive stem cells.


The duodenum was stitched up and separated from the aorta by omentoplasty.


Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.


Tumor response was determined by computed tomography scans obtained at the clinical discretion of the treating physicians.


They are generally well tolerated and have not been significantly implicated in renal toxicity.


We describe a case of PRES in a patient with collapsing focal glomeruloesclerosis (collapsing FGS) with complete recovery after withdrawal of cyclosporine (CSA).


She also developed hypotension that was thought to be caused by beriberi.


Studies for disseminated intravascular coagulation remained stable, and no clinical bleeding was seen.


RESULTS: The mean age and duration of illness of the patients were 38.93+/-8.36 and 12.88+/-6.90 years, respectively.


The cause of death was determined to be acute intoxication by olanzapine, and the manner of death was accidental.


It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.


SLE receded after withdrawal of carbamazepine and treatment with anti-inflammatory drugs.


Risk factors are discussed.


His condition improved without complications following the discontinuation of oral prednisolone and replacement with intravenous methylprednisolone.


In four of the patients, there was evidence of sodium depletion due to low sodium intake, diuretic administration, or vomiting.


However, the procedure was associated with a high incidence of cytomegalovirus (CMV) reactivation.


Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


Although urinary incontinence is listed as one side effect of these drugs in their package inserts there is only one report in the literature.


Gamma-hydroxybutyrate (GHB) is best known as a recreational depressant drug, whose use has also been implicated in drug facilitated sexual assault cases.


Fluorescein angiography confirmed leakage surrounded by central serous detachment of the retina.


Total ischemic time was 3 h 34 min and 3 h 35 min, respectively.


Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.


Weaning from the cardiopulmonary bypass was easy and uneventful in each patient.


Our findings suggest that it may also be used as a prophylactic agent.


Ibuprofen overdose is usually characterized by GI upset, dizziness, and mild sedation.


Management of hypertension and dyslipidaemia in patients presenting with hyperuricaemia: case histories.


Serology excluded an active infection.


Macrophage migration-inhibiting factor (MIF) assay with methylphenidate was positive.


Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: a preliminary study.


No known causal factors for pancreatitis such as biliary tract stone, hypertriglyceridemia and alcohol consumption could be identified.


Hyperthermic isolated limb perfusion (ILP) (2 mg, TNF-alpha and 100mg, melphalan) was performed for an irresectable right thigh desmoid tumor with calf extension in a 49-year-old man.


A 53-year-old man developed NMS without rigidity while taking olanzapine.


Adverse cutaneous reactions to low molecular weight heparin (LMWH) are uncommon in the literature.


Nephropathy caused by methicillin therapy for staphylococcal septicemia.


Recurrent hypotension immediately after seizures in nortriptyline overdose.


Ritonavir should be added to the list of drugs that can induce adverse cutaneous reactions in HIV patients.


Mild adverse cardiac and central nervous system effects are common with these medications, requiring modifications in dose or occasionally switching to a different medication.


This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.


This epileptic activity was continuous and unmodified by sensory stimulation and eyes opening and closing.


PATIENTS AND METHODS Patients with advanced PEComa were treated with sirolimus and consented to retrospective collection of data from their medical records and analysis of archival tumor specimens.


Because of secondary left ventricular dysfunction, digoxin was administered.


An uncommon cause of gastro-duodenal ulceration.


Withdrawal of Depakote resulted in resolution of the effusion.


The anatomy of the radial artery, the diagnosis of injury, and a treatment algorithm are presented so that potential devastating hand complications can be avoided.


Thus, intracoronary nitroglycerin can reverse coronary artery spasm that does not respond to systemic nitroglycerin administration.


Treatment consists of discontinuation of the offending drug and often high dose corticosteroids.


The cause of the intracranial disease was attributable to the retrograde cerebral venous congestion.


Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.


A high lamotrigine concentration was detected in the breast milk, and the neonatal lamotrigine serum concentration was in the upper therapeutic range.


Indirect immunoelectron microscopy showed antibody labelling in the lamina densa and sublamina densa zone.


Disulfiram encephalopathy as a cause of the catatonia syndrome.


We report a case of disseminated nocardiosis revealed by suppurative thyroiditis in a liver-kidney transplant recipient with poor nutritional status at the time of infection.


His fetishistic behavior was treated successfully using mirtazapine 15 mg/day.


Familial occurrence of cat-scratch disease, with varying clinical expression.


We now describe a case in which local catheter directed thrombolysis, via a peripherally inserted central catheter (PICC), was used to treat a large thrombus surrounding the tip of an indwelling central venous line that was causing superior vena cava obstruction (SVCO), in a patient with cystic fibrosis.


Since the first description by Cullen in 1924 (Surg Gynecol Obstet 1924; 38: 579-582) various case reports have been published.


OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.


We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously.


Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.


Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.


We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.


This is, to the best of our knowledge, the first report of a case in which agranulocytosis followed treatment with both propylthiouracil and methimazole in the same patient.


PURPOSE: To report a case of permanent endothelial cell injury after intracorneal penetration of milky latex from Calotropis procera (ushaar).


Effects of aprotinin on hemorrhagic complications in ARDS patients during prolonged extracorporeal CO2 removal.


We describe two cases of late postpartum hemorrhage following Cesarean section, attributed to pelvic arterial pseudoaneurysm, that were successfully treated by direct thrombin injection under ultrasound guidance.


He was self-medicating with this to relieve muscular cramps.


While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.


Methotrexate-induced papular eruption following treatment of psoriasis has not been previously reported.


This article presents a simple and effective alternative using hyaluronic acid for some patients requiring nasal recontouring.


Nimesulide is a new nonsteroidal anti-inflammatory (NSAID) drug with antipyretic and analgesic properties.


Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.


OBJECTIVE: To report a case of cutaneous and hematologic toxicity in a patient treated with IL-2.


In case #2, the concentrations of quetiapine found were 16 mg/L in blood (42 micromol/L), 120 mg/kg (310 micromol/kg) in liver, and 1.8 mg/L (4.6 micromol/L) in vitreous fluid.


This report will, hopefully, save other clinicians from encountering similar complications in any of their patients.


EPS resolved completely after discontinuing the neuroleptic agent and coincided with improved motor speed, set initiation, and verbal fluency.


BACKGROUND: Aggressive skin cancers on the cheeks may involve the parotid duct.


Oliguria was not observed and this feature may impair recognition of kidney damage.


It is indicated in many inflammatory skin conditions characterized by polymorphonuclear cell infiltration.


Gastro-oesophageal reflux associated with nifedipine.


The case histories and comments on the diagnosis and management of pulmonary nodules are reviewed.


Evidence from previous studies of neuroleptic side effects suggests that acute dystonic reactions are rare in elderly patients.


Moreover, chronic GVHD-related liver injury was noted at the time of this episode.


New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept.


This report suggests the feasibility of a strategy of bivalirudin use in patients who have some degree of heparin 'resistance' in the setting of complicated PCI.


Different reasons for the RPE atrophy such as collateral damage of the choriocapillaris with a subsequent secondary RPE atrophy, a direct photochemical effect due to the early localization of the photosensitizer in the RPE, or a depigmentation or photobleaching of the RPE, which led to a window defect in the fluorescein angiogram without loss of the major functional properties of the RPE, are possible mechanisms involved in the development of the documented lesion.


Most reports have been in adult patients, with rare reports in the pediatric population.


These data suggest that a primary immunoregulatory abnormality may be present in drug induced IgA deficiency.


We review these reports with comparison to our two cases.


In addition, a shorter hospital stay and improved quality of life are anticipated.


Three-quarters of the acute cases recovered with full occupation capacity.


CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.


In lead intoxication, nerves may incur mechanical damage.


A biopsy, performed 6 months later when the clinical appearance worsened, showed no tumor tissue.


On the 3rd day after a cesarean section, because of pre-eclampsia, blood pressure was still high, oral labetalol 100 mg with an 8-hour interval was given, followed by 50 mg i.v. administered over 10 min, twice with a 5-hour interval.


We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.


BACKGROUND: Extrapyramidal signs (EPS) typically are a late-presenting feature of sporadic Alzheimer disease (AD), but relatively little data are available regarding EPS in FAD.


Despite optimal response of the cutaneous lesions to treatment, the disease progressed and the patient died from infectious complications eight months after the appearance of the tumors.


Although she was born after vacuum delivery and a scalp swelling was noticed from the third day of life, this swelling disappeared completely at the age of 3 months.


Corneal scrapings were taken for microscopic examination and culture.


The patient developed classic signs of TLS within 24 h of chemotherapy, including acute renal failure.


Prominent neuroleptic sensitivity in a case of early-onset Alzheimer disease due to presenilin-1 G206A mutation.


Disseminated intravascular coagulation in acute monoblastic leukemia: response to heparin therapy.


In the first case report, the patient was switched to olanzapine ODT in daily dosage of 20 mg, while in the second case report, the patient was switched to olanzapine ODT in daily dosage of 15 mg, and weight loss was similar (14 kg vs. 15 kg).


Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.


In conclusion, NCPH should be included in the differential diagnosis of HIV-individuals presenting with clinical manifestations of portal hypertension and well preserved liver synthetic function.


In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.


However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.


Methylglyoxal bis-dihydrochloride is a drug that has been available for use in cancer chemotherapy since 1955.


PARTICIPANTS: Four patients (3 with spinal cord injury, 1 with cerebral palsy) with implanted ITB infusion pumps for treatment of severe spasticity, who had ITB withdrawal syndrome because of interruption of ITB infusion.


Thrombophilic screening revealed no abnormalities except heterozygous F V G1691A.


After delivery, she had diastolic hypertension and proteinuria and was prescribed magnesium sulphate.


Brucella infection in total hip replacement: case report and review of the literature.


We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).


A brain magnetic resonance image showed multiple high signal intensities on T2-weighted images predominantly located at the parietooccipital lobe.


The white matter was affected by severe myelin pallor, edema, and a prominent macrophage infiltrate in each of the cases.


A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.


We suggest that intraocular lens manufacturers refrain from providing such identification on their products.


He developed immune-mediated diabetes mellitus with low C-peptide and positive antiglutamic acid decarboxylase antibody after completion of therapy.


Bilateral computerized tomography showed no progression in radiographic changes during the treatment.


The clinical features included fever, severe myalgia, documented fungemia with F. solani, an ecthyma gangrenosum-like lesion next to a peripheral venous catheter, and disseminated pustules.


Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.


We report the pharmacological treatment of a case of alternating hemiplegia of childhood (AHC) in a 14-year-old female with an established diagnosis.


A diagnosis of extrahepatic cholestasis was first suspected, due to the observation of a duodenal diverticulum and dilated proximal choledocus.


CASE SUMMARY: A 67-year-old woman received radiotherapy and immunotherapy for cancer that had metastasized to the bone and lungs.


Frequency of cough is variable and although this complication has been described as a class effect, patients with a persistent, severe ACE inhibitor-induced cough may benefit from a trial of fosinopril therapy.


The 125I-insulin binding rate was high (54%).


Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.


The patient had severe hypoxemia associated with bilateral pulmonary infiltrates.


Markedly elevated blood pyruvate and alanine levels also decreased to normal.


It appears that the leukoencephalopathy of the present case developed on the more complicated etiopathogenesis.


Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.


CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.


Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.


Because of a hypersensitivity reaction, initial therapy with penicillin G and gentamicin was stopped and substituted with cefazolin.


CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus.


Kennedy Institute in Glostrup, Denmark.


Monitoring serum digoxin concentrations during digoxin immune Fab therapy.


Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.


The possible role of interferon beta in the pathogenesis of sarcoidosis in this patient is discussed.


RESULTS: After treatment, seven of the eight patients had healing of their ulcers, prompt reduction in their pain, and improvement in livedo reticularis and purpura.


The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway.


We have described three patients with hepatitis C for whom IFN-alpha and ribavirin were prescribed and who developed two successive phases of silent thyroiditis followed by hyperthryroidism relapse due to Graves' disease.


He had no organic disease likely to cause SIADH.


OBJECTIVE: The aim of this report was to highlight the fact that hearing loss in thalassaemia patients can be related to marrow expansion affecting the ossicles, resulting in a conductive loss.


A case study is presented of a licensed practical nurse who developed persistent contact dermatitis.


Acute renal failure in a child associated with acyclovir.


The massively obese patients had an increased risk of cancer and complications from therapy.


Toxic epidermal necrolysis resulted after 19 days of treatment with 5-fluorocytosine and amphotericin B.


Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.


Temsirolimus-induced glomerulopathy.


We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.


We treated 21 patients with stage D prostatic adenocarcinoma who had had unsuccessful hormonal therapy with a combination of 600 mg. per M.2 per day estramustine phosphate (Estracyt) and 15 mg. per M.2 per day prednimustine (Stereocyt, Leo 1031) in daily oral doses.


Primary spontaneous coronary artery dissection is a rare condition but one that must be considered when young people, especially post partum women, present an acute ischaemic syndrome.


Here we describe another case of VOD occurring after LT, but in which the causative role was played by azathioprine.


Severe methotrexate toxicity occurred in two of these patients.


A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.


Fourteen days after discontinuation of G-CSF therapy his monocyte counts returned to normal levels and a marrow aspirate showed a reduction in blast cells.


Fatal intracerebral hemorrhage during dental treatment.


The clinical and hemodynamic characteristics of the patients were as follows.


Drug induced myopia associated with treatment for gynecological problems.


Psychosis was stable with flupentixol monotherapy.


BACKGROUND: Interferon beta has become standard therapy for reducing relapse frequency in relapsing/remitting Multiple Sclerosis (RRMS).


Further work-up led to the diagnosis of anterior spinal artery syndrome.


An objective causality assessment indicated a probable relationship between clotting abnormality and warfarin administration, although the degree of elevation of the INR was unusual in the light of the daily warfarin dose and duration of its exposure.


During a period of 4 years, the boy was examined six times with electroretinography.


Because of its favorable tolerability profile it appears to be a preferred alternative, especially in NSAID-sensitive patients.


The main outcome measured was intraocular pressure (IOP) in mm Hg.


It seems that trigeminal manipulation during dental treatment as well as increased serum levels of induced epinephrine mainly by stress and pain, and the small amounts absorbed from the site of local anesthesia might produce abrupt elevation of blood pressure, subsequent increase in cerebral blood flow and severe, even fatal intracerebral hemorrhage.


Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma.


She was induced into CR by ALL-directed chemotherapy and then maintained with IFN-alpha2b together with weekly rotational chemotherapy.


Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis.


However, 4 days later the ocular pressure of the first patient increased to 22 mmHg, which led to suspension of the drug.


Inhibitory effects of various drugs on dual asthmatic responses in wheat flour-sensitive subjects.


Hemorrhagic stroke following elective cesarean delivery.


CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.


The in vitro susceptibility assay showed that the clinical isolate was resistant to foscarnet, moderately resistant to ganciclovir, but sensitive to cidofovir.


Bromocriptine-induced schizophrenia.


A case is reported in which posterior synechiae to the manufacturer's trademark on the surface of a Shearing intraocular lens were noted ten days after the implantation of the lens.


BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.


Autopsy revealed no pathologic findings in the heart or in the extra- or intracranial arteries.


No change in thrombus size was seen on a followup echocardiogram after 4 days.


Chronic viral infection relapsed after the suspension of the IFN-alpha therapy.


The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis.


The interaction of these factors are analyzed in this report.


The boy is now 14 months off tuberculostatic treatment and 8 months off AML therapy.


These re-calculations revealed unexpectedly high doses in the range 79 to 82 Gy (cumulative external and brachytherapy dose) at the level of the optic nerves, which explained the observed radiation injury.


Normalisation of phenytoin levels was associated with return of euthyroidism.


We report the use of pamidronate for acute, severe hypercalcemia secondary to iatrogenic vitamin D poisoning.


Additionally, clinically effective doses of conventional antipsychotics can actually aggravate negative symptoms through the development of extrapyramidal symptoms (EPS).


Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events.


Their attenuation density values were appreciably less than that of calcium and they enhanced slightly with contrast.


We report two adults who received gabapentin (GBP) and subsequently developed behavioural side effects.


The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.


CONCLUSION: All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment.


The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment.


We conclude that vincristine and actinomycin D were the cause of this rare from of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.


A case of cataract development in a patient with atopic dermatitis is presented.


(3) A 61-year-old woman with active refractory Wegener's granulomatosis who developed respiratory insufficiency due to aspergillus and pseudomonas pneumonia.


To our knowledge, this is the first such description of this phenomenon in the literature.


A case is presented, in which the extrapyramidal side effects of depot pipotiazine lasted well over 6 months, and possibly the therapeutic effect for almost 12 months following the last injection.


This patient may have been at increased risk for this interaction secondary to his age and history of alcohol abuse.


Decompression sickness and arterial air embolism which follow exposure to raised environmental pressures of compressed air are usually adequately treated by accepted recompression procedures of relatively short durations.


Although this can be coincidental, it can also suggest that the basis of a thrombus may dissolve first with any, including oral, anticoagulation.


In four patients, thrombosis occurred 2-45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan.


All abnormalities were transient, with recovery a few days after foscarnet withdrawal.


The patient's headache resolved with diltiazem therapy and she was able to complete capecitabine and radiation therapy without further adverse events.


Maximum improvement may not be reached before 8 weeks.


The affected interlobular artery included concentric intimal thickening and thrombosis in the lumen.


Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia.


CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda.


Death occurred 4 to 16 weeks later.


DISCUSSION: Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to cause TEN.


There was no reaction to the antibiotics.


These mutations were not present in samples obtained during the primary CMV infection.


Macrodantin: a cautionary tale.


We describe the effect of multiple cycles of 5-fluorouracil administration in a patient receiving warfarin therapy.


Three children completely recovered; one patient relapsed and died.


This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.


A 21-year-old woman presented with a 1-month history of whitish bubbling of the palms after brief exposure to water.


Many past cases of SMON have occurred in Japan but since 1975 no new cases have been reported.


A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.


An emergency tracheostomy was life saving.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Report of a case.


The mare subsequently delivered a healthy foal.


Parents were thoroughly questioned but we could not find out a new traumatic head event.


Clinic records were reviewed to extract clinical and laboratory data.


A 35-year-old woman presented with neurotoxicity correlated to an i.v. regimen of 5-fluorouracil as episodes of acute confusional state and abnormalities of symmetrically restricted diffusion in the periventricular white matter and corpus callosum.


Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.


Hypertonic sodium bicarbonate is recognized as effective therapy for hypotension and arrhythmias.


Over the last five years three new classes have been released.


Based on this report and previous case reports, caution is advised when concurrent warfarin and 5-fluorouracil are prescribed.