INTRODUCTION: We are reporting a case of bladder contracture post intravesical bacillus Calmette-Guerin (BCG) therapy; to our knowledge only two cases were reported.


Morphological findings on sural nerve biopsies revealed both axonal degeneration and segmental remyelination.


Diagnosis, therapy, and complications of therapy are discussed.


Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.


Only 2 cases of spinal lipomatosis in HIV-related lipodystrophy have been reported.


The critical care provider is faced with deducing the etiology and treatment of delirium in the ICU.


OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.


CONCLUSION: Most GHD patients have intact posterior pituitary function.


Epidural steroid injections are relatively safe procedures, although the risk of hemorrhagic complications in patients undergoing long-term anticoagulation therapy is higher.


We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.


The patient remains free of both leukemia and fungal disease more than 4 years after transplant.


Patients with cancer should be aware that alternative remedies may be harmful and ineffective.


Lithium's effect of parathyroid hormone.


In all patients, discontinuation of aromatic AEDs resulted in resolution of symptoms and in 3 patients who required continued AED therapy, valproic acid was well tolerated.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


A 71-year-old man presented with herpes zoster ophthalmicus and ocular involvement.


In some cases they may cause serious complications.


Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.


Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.


Possible mechanisms and potential therapies are discussed.


A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.


CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.


We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.


Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


After withdrawal of ibopamine and under continuation of all other concomitant medications her body weight continued to decrease during the following few days, her symptoms were alleviated and she was discharge to a nursing home.


Ciprofloxacin is one drug that has been reported to cause interstitial nephritis.


In 3 consecutive cases in which a small break in the thin conjunctiva adjacent to the scleral flap was created during trabeculectomy, sodium hyaluronate 2.3% (Healon5) was intraoperatively injected into the bleb.


Over two-thirds of the patients treated with intravenous cimetidine demonstrated a reduction in gastrointestinal symptom severity, and a statistically significant reduction in the mean severity rating for all patients was observed.


We discuss the association of immune suppression and melanoma.


Primary pneumococcal peritonitis complicated by exudative pleural effusion in an adolescent girl.


Unwanted corticosteroid effects in childhood bone marrow failure, renal failure and brain damage: case report.


A patient with end stage renal disease secondary to systemic lupus erythematosus (SLE) ultimately required amputation of the four extremities and developed mesenteric ischemia.


Venography demonstrated a large atrial thrombus in the superior vena cava and right atrium.


Trimethadione treatment may be a useful tool for chemical dissolution of pancreatic stones.


This is the first case where epoprostenol has been successfully reinstituted.


Ileal biopsy revealed an erosive enteritis with mucosal inflammatory infiltrate and disruption of the surface epithelium.


The scant information available in the published literature regarding this phenomenon is reviewed with regard to 5-fluorouracil.


The antibiotic and cyclosporine were stopped and the child was managed with furosemide, nifedipine and steroids.


However, the pathologic diagnosis was meningioma.


An unusual complication of chemotherapy: an abscess in the pterygopalatine fossa.


Within 10 days after cystoscopy causing urosepsis this patient developed persistant neckpain as initial symptom of vertebral osteomyelitis.


Incidence of myopathy in patients treated with antimalarials.


A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.


Later, both patients evolved to non-Hodgkin's lymphoma (NHL) (diffuse large B-cell lymphoma and peripheral T-cell NHL, respectively).


However, severe limiting headaches are rarely experienced in this setting and no known therapy has been described for such a serious side effect.


Histologic examination of the excised specimen showed chronic granulomatous inflammation, and subsequent microbiologic studies cultured an acid- and alcohol-fast bacillus that was later identified as Mycobacterium fortuitum.


Re-administration of a combination of chemotherapy + Gemtuzumab at relapse in CD33+ AML patient allows to second remission and is feasible without extra toxicity.


We suspect that similar syndromes reflecting injury to the spinal cord injury may be unrecognized following surgical repair of coarctation.


Although TPN appears to be beneficial in some patients with cancer, it is expensive and is associated with several significant disadvantages.


A biopsy specimen showed neutrophilic panniculitis.


Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.


Three patients with progressive multifocal leukoencephalopathy (PML) treated with highly active antiretroviral therapy (HAART) worsened clinically and radiologically.


Nasopharyngeal cancer is not common in the Caucasian population; however, there is a much higher incidence in Asian patients.


RESULTS: Visceral leishmaniasis was established by bone marrow aspiration, and although there was no histological confirmation, according to HLH-2004 criteria, a secondary macrophagic activation syndrome was established.


Despite maximal anti-glaucomatous medication, IOP still could not be controlled.


The combination therapy resulted in abrupt alleviation of psychotic symptoms in one of the cases, and maintenance with low-dose clozapine allowed for long-term efficacy.


Vapreotide, a new somatostatin analogue in the palliative management of obstructive ileus in advanced cancer.


On comparing the amino acid sequence of the index patient with the consensus sequence, five mutations were found at pre-S1, five at pre-S2 and twenty-three mutations at the S region.


CIDP may occur early or late during the treatment course with TNF-alpha antagonists.


The patient had been treated successfully in the hospital with intravenous methylprednisolone.


We report a 71-year male with castration-resistant metastatic prostate cancer who was treated with weekly docetaxel for 12 weeks and developed significant eye irritation and dryness during treatment.


We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.


CASE DESCRIPTION: A patient with congenital afibrinogenemia presented with recurrent hemiparesis.


The attributable mortality rate is 15%, with the most significant factor being treatment delay (mean time from presentation to initiation of treatment, 6.74 weeks).


ACE inhibitor fetopathy is characterized by fetal hypotension, anuria-oligohydramnios, growth restriction, pulmonary hypoplasia, renal tubular dysplasia, and hypocalvaria.


The use of botulinum toxin in the treatment of a parotid duct injury during Mohs surgery and review of management options.


Serum antinuclear antibodies were positive (1:640 speckled pattern), and anti-double-stranded DNA was positive (1:80); moreover, positivity of anti-extractable nuclear antigen was observed.


Animal models showing paradoxical or opposing responses to serotonin-enhancing agents may apply to human sexual functioning as well.


SASP is known to be mainly metabolized by N-acetyltransferase 2 (NAT2), and acetylation phenotypes (rapid, intermediate and slow acetylator) correlate with NAT2* genotypes.


In both cases, CSF pleocytosis was limited to 20 or 60 cells with variable protein and sugar values.


Investigations showed abnormal liver function tests, pancytopenia and elevated serum levels of aflatoxins.


Haemolytic-uraemic syndrome complicating long-term mitomycin C and 5-fluorouracil therapy for gastric carcinoma.


A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.


Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.


The possible mechanisms for this severe elevation of the calcium level are discussed.


She was receiving phenytoin sodium 300 mg/day; carbamazepine 200 mg four times daily had been discontinued four days before admission because of leukopenia.


From September 5 to November 4, 1991, four consecutive patients placed on centrifugal ventricular assist devices (VADs) for cardiac failure were supported with Biomedicus pumps coated with the Carmeda bioactive surface.


Focal renal cortical necrosis associated with zomepirac.


A patient developed transient, acute myopia while on isotretinoin (Accutane) therapy for acne.


A review of the literature was carried out with special reference to the significance of clinical myopathy with a negative biopsy.


It has been observed after a variety of lesions affecting the posterior nerve roots, the spinal ganglia and the peripheral nerves.


RESULTS: The patient retained excellent visual acuity and the choroidal hemorrhage resolved completely within two months.


Sagittal sinus thrombosis associated with transient free protein S deficiency after L-asparaginase treatment: case report and review of the literature.


He had experienced subarachnoid hemorrhage (SAH) from a left vertebral dissecting aneurysm, and had subsequently received a ventriculoperitoneal shunt against post-SAH hydrocephalus.


Histological improvement with lamivudine therapy for de novo hepatitis B occurring in an anti-HBs-positive child after bone marrow transplantation.


Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.


Allergic contact angioedema to benzoyl peroxide.


The patient tolerated enalapril, and lisinopril without problems.


However, the concentration of MHD, which peaked 7 h after intake, was only twofold higher (59.0 mg l(-1)).


CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.


In animals AmB incorporated into liposomes is highly effective against experimental leishmaniasis, with low toxicity.


These data support the hypothesis that a defect in drug detoxification was responsible for the child's susceptibility to this drug hepatotoxicity.


The mechanism was proven by ribotyping of the microorganism and postmortem pathology.


The ampules of tranexamic acid (500 mg/5 mL) and bupivacaine (5 mg/mL, Merck, Darmstadt, Germany) were similar in appearance.


The literature on these associations is reviewed.


PATIENTS: Two patients with phantom limb pain after total hip disarticulation.


Combined renal tubular acidosis and diabetes insipidus in hematological disease.


Although enteral nutrition is generally advocated in the care of children with cancer, those patients receiving intensive chemotherapy alone or in combination with bone marrow transplantation often require total parenteral nutrition (TPN).


In these patients, the left atrial overload seemed to be severe.


The response to antimicrobial therapy was better in the more recent cases.


It can be caused by immunosuppressive drugs or autoimmune diseases.


The patient's visual acuity, eye movements and the pupillary defect did not improve in the affected eye even after mechanical decompression within 30 minutes and medical treatment, neither in the early period nor during the following two months.


The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.


We report the case of a 70-year-old female who experienced a graft enteric erosion (GEE) three years after a right aorto-femoral bypass.


To date, clinical experience of rFVIIa administration in neonates, especially preterms, is rather limited, because of the lack of controlled studies and based solely on some published case reports and 1 prospective pilot study.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Clinical and ethical considerations are discussed.


The discordant time course behaviour of hematocrit and blood pressure points to the importance of residual renal tissue for blood pressure to develop during erythropoietin therapy in the renoprival status.


Combination chemotherapy with VM 26 and CCNU in primary malignant brain tumors.


Over a 5-year period, we observed three patients with a 3-15-year history of migraine, who received sumatriptan for acute headache.


It has been found to cause a nonanion gap metabolic acidosis in some patients, which is related to carbonic anhydrase inhibition.


Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.


We describe a case of Brugada syndrome, in which a coved type ST-segment elevation was enhanced by antihistamines and antiallergenic drugs.


Two patients are described who developed testicular swelling and pain during treatment with desipramine.


The effectiveness of multidrug treatment by bleomycin, methotrexate, and cis-platinum in advanced vaginal carcinoma.


k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.


This is the first report of a chronic myeloproliferative disorder following successful treatment of hairy cell leukemia.


Case studies of three patients with SCs and the 8% of survey participants with SCs only are in focus.


Though they are generally considered safe, there have been a few reports of myocardial infarction and stroke associated with triptan use.


We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.


Physicians should keep in mind that taxanes such as paclitaxel have the potential to cause pneumonitis and lung fibrosis.


Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation.


After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.


Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.


Mycobacterium abscessus infection after use of tumor necrosis factor alpha inhibitor therapy: case report and review of infectious complications associated with tumor necrosis factor alpha inhibitor use.


The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.


The case of a patient with CPH, who had marked epigastric symptoms with indomethacin treatment and responded well to topiramate 150 mg daily, is reported.


Recently, CD20-negative tumors have been described after Rituximab therapy.


Her history was significant for coronary artery disease, atrial fibrillation, deep venous thrombosis, pulmonary embolism, chronic steroid use, and recurrent urinary tract infection.


This report describes the clinical course of the patient over a period of 4 months after the nerve block and the post-mortem findings along with a brief review of the literature.


However, like alcohol, their use can sometimes be a significant part of a dependence problem.


DISCUSSION: There are similarities in symptoms between serotonin syndrome and clozapine withdrawal.


The reduction in the 125I-insulin binding rate and the binding capacity of the high affinity site of insulin antibodies were balanced after oral glucocorticoid therapy.


In this case this activation of the calcium sensing receptor was triggered by amikacin.


Adverse reactions also were more common in patients who had not received rauwolfia derivatives prior to admission; however, this group of patients also received IM reserpine more frequently.


Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.


Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.


Massive plasmocytosis due to methimazole-induced bone marrow toxicity.


Reexposure to the drug was reported in three patients but was uncomplicated in only one.


Bronchoalveolar lavage performed 48 hours after the end of challenge exposure showed a marked increase in neutrophils (60% of total cell count).


The addition of catecholamines to local anesthetics should be considered.


The rapid progression under medical therapy prompted us to replace the thoracic aorta with an 8-mm polytetrafluoroethylene graft, using extracorporeal circulation and core cooling.


CONCLUSION: Routine implementation of computed tomography for 3D dose planning purposes is therefore advocated.


Risperidone-induced tardive dyskinesia.


A 31-year-old, white man was admitted after sustaining a gunshot wound to the chest and mandible.


The biopsy showed inflammation only, and other microbiological workup was negative.


Intradermal and patch tests to liquid prednisone were positive.


The inter-individual variation in the expression of this protein(s) and its potential induction by anticonvulsant therapy together with an inherited deficiency in drug detoxification capacity may explain predisposition to these immunoallergic reactions.


We review the existing literature on this rare clinical entity, all-trans retinoic acid-induced myositis.


After taking him off all drugs and administering spironolactone supplemented with potassium, his low serum potassium level was ameliorated.


Medication comprises of bronchodilators, corticosteroids and anticholinergic drugs.


Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.


The patient had initiated treatment with oral pantoprazole 40 mg/d for gastroesophageal reflux 2 months prior to admission.


However here we reported two patients, presenting with PD during high dose colchicine treatment for familiar mediterranean fever (FMF).


Two days after surgery, signs of orbital cellulitis developed in his right orbit.


For this reason, especially, in the regions where G6PD enzyme deficiency is common, people should be informed about the side-effects of topical henna application and clinicians should be aware of these manifestations.


In the 36th week of gestation, the patient was introduced nitrofurantoin 100 mg a day due to symptoms of dysuria and enterococcus isolated from urine culture.


All responded to treatment.


Five had acute lymphoblastic leukaemia (ALL) (one bcr/abl positive), six had acute myeloid leukaemia (AML) with immunophenotype and/or cytogenetic intermediate-high risk features, except one patient with acute promyelocytic leukaemia (APML).


Enzyme replacement therapy for Gaucher's disease in patient treated for non-small cell lung cancer.


The medical chart of the patient was reviewed.


Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.


The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.


In cases of mild increments of eosinophils and if the patient is asymptomatic, there is no need to make an immediate decision.


The possible role of AK inhibition in these clinical responses requires further investigation.


Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.


AIMS: To present a case of piloerection after replacing fluvoxamine maleate with milnacipran hydrochloride, and to analyse this effect based on receptor occupancy theory.


We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment.


Percutaneous or transvaginal ultrasound-guided direct thrombin injection is a simple procedure that does not require any sophisticated surgical or radiological equipment.


We describe three blood brothers who were involved in pottery glazing and suffered from repeated episodes of severe abdominal pain, nausea, vomiting, constipation and anemia due to lead toxicity.


This case report illustrates the importance of early detection of drug-induced hepatotoxicity and timely drug discontinuation to prevent the need for liver transplantation.


Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.


Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.


Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.


She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.


Clinicians need to be aware of this drug-induced condition and the potential increased risk associated with concurrent use of multiple psychotropics.


Initially, she was started on Pancrease MT 16, which was subsequently discontinued because fecal fat studies were normal and she seemed to do well on Nutramigen and vitamin supplements.


This therapeutic regimen, coupled with further intervention, allowed resolution of the thrombotic complication without bleeding.


Subjects received 1.2 to 2.88 gm over 12 to 18 days.


Zygomycosis in a 13 year old girl with T-NHL.


Herein, we present a case of Majocchi's granuloma of face, a site rarely involved, in an immunocompetent patient.


It is entirely excreted through the renal system so this needs to be considered in any patient becoming acutely ill and developing renal failure.


Erection subsided spontaneously after 4 hours, with subsequent potency unimpaired.


Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin.


This clinical management may offer an alternative to treatment suspension.


Further efforts are required to fully establish the cardiac transplantation program in Japan.


Patients should be aware that this is a rare, albeit serious, complication of treatment with rituximab.


By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.


Because it was not a stocked item in our pediatric emergency cart (as well as at another hospital, necessitating a transfer of a patient with refractory seizures to our hospital), the average delay was 5.8 hours (range, 1.3 to 13 hours) before it was given.


We report a series of three patients who whilst using topical facial steroids developed advanced glaucoma.


On-going monitoring of alteplase-treated patients may allow the opportunity to perform rescue intra-arterial therapy.


We here report our preliminary clinical experience with caspofungin as an additional drug to the standard trimethoprim-sulfamethoxazole regimen.


Mecasermin [rDNA] (Increlex; Tercica, Inc.) is recombinant insulin-like growth factor-I (IGF-I) that has been approved to treat growth failure in children with severe primary IGF-I deficiency.


Symptoms were slow to resolve after penicillamine treatment was discontinued, and four of the patients needed corticosteroid therapy.


However BUN and serum creatinine continued to increase and peaked on the following day at 8.6 mmol/l of urea (24 mg/dl) and 194 mumol/l (2.2 mg/ml), respectively.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.


Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.


The response to surgical drainage and antimicrobial therapy was dramatic in both dogs, but one dog experienced a drug reaction to trimethoprim-potentiated sulfonamide.


Here, we describe a case of Epstein-Barr virus-associated polymorphic PTLD that developed shortly after treatment for cytomegalovirus reactivation in a lung transplant recipient who was preoperatively seropositive for both cytomegalovirus and Epstein-Barr virus.


Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome.


However, at the same time, multiple cutaneous violaceous papular-nodular lesions appeared on his left forearm.


Histopathologically, a degenerative, inflammatory thyroiditis was evident.


Subsequently he responded to the West Berlin Protocol.


4-en-VPA (2-propyl-4-pentenoic acid) (5%-21% in plasma) and 4,4'-dien-VPA (2(2-propenyl)-4-pentenoic acid) (4%-7%) have been found as abnormal unsaturated metabolites not detectable in controls.


One patient who was weaned and survived had multiple thromboembolic strokes.


We report two cases in which acute paraplegia occurred following compression fracture without retropulsion of bone fragments or significant narrowing of the spinal canal.


We report a case of calciphylaxis in a patient with normal renal function and hypoparathyroidism, who responded to treatment with sodium thiosulfate.


CD-20 expression in post-transplant lymphoproliferative disorders: treatment with rituximab.


We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.


We describe a patient who developed adrenal insufficiency (AI) after this protocol.


We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.


The hepatotoxicity is probably due to (-)-epigallocatechin gallate or its metabolites which, under particular conditions related to the patient's metabolism, can induce oxidative stress in the liver.


The acronym 'EMPACT' is suggested (E: erythema; M: multiforme; associated with P: phenytoin; A: and; C: cranial, radiation; T: therapy) to best describe this disorder.


METHOD: Recombinant human growth hormone (rhGH) is a newly approved treatment for weight loss and wasting in patients with AIDS.


Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


We assume that rIFN-gamma induced the de novo development of SLE in our patient.


She had palpable cervicosternal fibrosis measuring 10 x 8 cm, with local inflammatory signs and functional consequences (cough, restricted cervical movement, dyspnoea and bronchitis) with a SOMA scale for grading the long-term side effects of radiation therapy of 19/14.


Leflunomide-associated weight loss in rheumatoid arthritis.


These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma.


Three nephrotic patients who had reduced renal function and active renal disease with progressive deterioration of renal function prior to the use of MP developed transient renal failure following an MP pulse therapy.


Later, more careful research showed that they are not directly associated with the antipsychotic activity of neuroleptic agents.


A single dose of dichloroacetate (DCA) was associated with a decrease in the serum lactate level by 20%, which persisted for more than 24 h.


We describe an infant who developed juvenile glaucoma with buphthalmos while receiving systemic steroid treatment.


The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.


With these measures PaO2 could be maintained of safe levels but PEEP and high inspired oxygen concentrations were needed postoperatively until the trachea could be extubated on the third postoperative day.


According to the Naranjo probability scale, the papular eruption was probably caused by methotrexate.


Although heliox has been used foryears to treat patients with various respiratory complications, it is not currently a common treatment instituted by anesthesia practitioners for the treatment of bronchospasm.


The patient was treated with full mouth gingivectomy and 2-week recall visits for a period of 2 months consisting of oral physiotherapy instructions, scaling, and topical fluoride application.


Relevant literature data are discussed.


Based upon the success of three refractory cases treated by this procedure, recommendation are made for the conversion of standard compressed-air chambers into an emergency saturation mode for therapy.


Given the paradoxical efficacy of the atypical antipsychotics in pure OCD, the neurobiology and comorbidity of OCD and schizophrenia, as well as the increasing use of atypical antipsychotics, a cautious and rational pharmacotherapeutic treatment approach is recommended.


CASES: Two postmenopausal women treated with tamoxifen and progestational agents for breast carcinoma developed uterine enlargement and intermittent spotting.


This condition can manifest as fever, myalgia, arthralgia, and Sweet syndrome, accompanied by distinct magnetic resonance findings involving the lower extremity musculature.


The present case indicates that the neutropenic colitis can occur under neutropenic conditions induced by the standard-dose chemotherapy for solid cancer.


Gold-induced pneumonitis is a rare complication of gold salt therapy.


We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.


A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.


Atopic cataracts versus steroid cataracts.


Hyperpigmentation is one of the cutaneous side effects of chemotherapautic agents, but it is usually accepted as a cosmetic problem.


METHODS: We describe a patient with MS in remission who had not exhibited any signs of IBD in the past.


RESULTS: After cessation of topical dipivefrin application and successful surgical repair of entropion, no recurrence of signs or symptoms has been reported.


We report the case of a 43-year-old man with ITP refractory to steroids and intravenous immunoglobulin who developed acute respiratory distress syndrome (ARDS) after a single infusion of rituximab.


The patient developed a severe infection of the upper and lower respiratory tract with bilateral pulmonary infiltrates and severe hypoxemia.


The symptoms of pseudotumor cerebri disappeared within 10 days.


We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.


Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.


Approximately 70% of the cases manifested as inflammation of internal organs or tissues and 30% manifested as a dermatitis or mucositis.


Bilateral recurrent pneumothorax complicating chemotherapy for pulmonary metastatic breast ductal carcinoma: report of a case.


Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.


The authors report an open study of 30 cases of intradiscal injection of triamcinolone hexacetonide in the treatment of sciatica.


The baby girl was fed with pasteurized maternal milk, and she had a normal growth.


CONCLUSION: The profound hypoxemia in this case was likely due to a combination of intra- and extrapulmonary shunt, both augmented by sodium nitroprusside.


Dihydropyrimidine dehydrogenase (DPD) activity was measured by radioisotopic assay using lysates of peripheral blood mononuclear cells.


The criterion for severe infection was inpatient hospitalization.


HHV-6B infection caused or triggered severe gastrointestinal inflammation with intractable diarrhoea and failure to thrive over several months.


Report of a patient with severe transfusion-related acute lung injury after multiple transfusions, resuscitated with albumin.


Hiccups can arise from idiopathic, psychogenic and organic causes.


A spinal haematoma occurring in the subarachnoid as well as in the subdural space in a patient treated with anticoagulants.


OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.


Treatment was given as direct observed therapy (DOT) and sputum cultures, blood chemistry and neurologic examination were undertaken on a regular basis.


The authors caution that treatment with alprazolam may be complicated by the induction of mania.


Lethargy in a newborn: lithium toxicity or lab error?


Pulmonary thromboembolism following total laryngectomy and neck dissection: a case report.


Diagnosis requires CT scan and direct aspiration and culture of the liver abscess.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


The role of chemotherapy in the induction of such secondary tumors after transplantation is discussed, and a proposal for the approach to these patients is suggested.


Here we present a forty-two-year-old Caucasian female with altered mental status, inability to eat, speak or walk properly, with shaking and vomiting for three days.


Shortly after the start of surgery, he suffered an allergic reaction that, at first, was difficult to distinguish from the recognised side-effects of intrathecal diamorphine.


Myoclonic twitching in the lower limbs of a patient who received intrathecal narcotics is described.


We present a rare case of a thrombus at the aortic arch found 1 month after cisplatin-based chemotherapy in a 50-year-old patient with a diagnosis of small cell lung cancer; there were no symptoms related to the thrombus.


We believe this is a remarkable potentiation on record in the literature.


Antithyroid treatment during pregnancy should allow the use not only of PTU but also of CBZ and methimazole.


Since therapeutic trials have failed, prevention of possible causes is the only way to avoid this rare but severe complication of cardiac surgery.


Transnasal fiberoptic laryngoscopy revealed a significant laryngeal hematoma, as well as a hematoma on the floor of the mouth and in the tonsil area.


DISCUSSION: Propafenone is a class 1C antiarrhythmic agent that blocks fast sodium channels in heart muscle and Purkinje fibers similar to the action of encainide and flecainide.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


METHODS: We present a case of intraoperative erection after the initiation of continuous spinal anesthesia that was treated with intravenous glycopyrrolate.


Therapy was adjusted as required on the basis of BCG sensitivity results.


However, the clinical role of S-1 in patients with recurrent/metastatic head and neck cancer is still uncertain.


Dermatological signs are found in 50% of cases, and are often diagnostic.


In May of 1997 a drug inadvertently injected intrathecally caused severe neurological damage and death to a child.


We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.


A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.


The novel antipsychotics offer great potential for improving compliance.


Multiple keratoacanthomas after megavoltage radiation therapy.


Leukocyte histamine release test with salmon calcitonin and serum tryptase levels at baseline and after intramuscular challenge test were performed.


A number of patients also had acute gastrointestinal hemorrhage.


Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly.


Acetazolamide (AZ) is mostly excreted in the urine, therefore, the blood levels of AZ often tend to increase in patients with chronic renal failure.


It produces clinically malignant multivesicular infiltrating lesions most often in the liver, and is quite different from the usual cystic variety caused by E. granulosus.


Therapy with the zinc-saline dressings was continued and restoration of all tissues was documented within 225 days.


Recombinant hirudin (lepirudin), a thrombin-specific inhibitor, provides safe and effective anticoagulation in such patients.


Ninety-nine of 171 (57.9%) patients were also prescribed prednisone.


RESULTS: Twenty-five patients were recruited in each treatment arm (50 in total).


CD4 count was 326 +/- 124 cells/mL (range, 198-467) and all patients presented HIV viral load < 75 copes/mL.


Gemcitabine-associated hemolytic-uremic syndrome.


Cytomegalovirus (CMV) pneumonia in the setting of non-transplantation patients is a rarity.


The drug should be withdrawn immediately if there is a suspicion of blood disorders.


Palatal tremor (formerly palatal myoclonus) is an extremely rare, but potentially treatable cause, of objective tinnitus.


Methemoglobinemia may occur after the administration of various drugs, including some local anesthetics.


2). These findings were characteristic of granular parakeratosis.


Although the cornerstone of treatment for AWS remains benzodiazepines, this case highlights the potential utility of phenobarbital in patients with resistant AWS.


Within days, she developed paranoid ideation, profound psychomotor retardation, increased depression, and fatigue.


Here, we describe two patients who developed severe proteinuria after renal transplantation, despite effective blood pressure control with an ACE inhibitor.


After the switch to aripiprazole, the patient's psychotic condition improved.


Here, we report for the first time the induction of a subfulminant autoimmune hepatitis (AIH) after four months of a successful treatment of HCV-1b infection using peg-IFN and ribavirin, in a 48-year-old woman co-infected with HIV.


The most common causes of sudden cardiac arrest are massive pulmonary embolism (PE) and acute myocardial infarction (MI).


This is the first report to document ocular motor abnormalities associated with midbrain dysfunction in ODS.


Videopolysomnographic and pharmacokinetic studies with monitoring of plasma levodopa levels demonstrated marked motor hyperactivity during augmentation, with anarchic discharges of motor unit potentials, tonic grouped discharges and flexor spasms, associated with painful dysesthesia.


Three patients presented with myoclonic seizures refractory to valproic acid and the usual antiepileptic therapy.


The parasite that causes this infection is usually transmitted by the sandfly and occasionally by nonsterile needles among intravenous drug users.


Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.


CONCLUSIONS: Itraconazole-induced liver injury presents with a cholestatic pattern of injury with damage to the interlobular bile ducts, possibly leading to ductopenia.


It may become manifest as perilesional linear, depigmented, atrophic streaks, which are usually most prominent in patients with dark-colored skin.


Two weeks later he was seen with a 5-kg weight gain, shortness of breath, bibasilar rales, +S3 gallop, and increased jugular venous distention.


Almost all of the suspected adverse drug reactions (ADR) from 1% lindane have involved substantial misuse.


Verapamil in effort-induced angina pectoris in patients with normal coronary arteries.


PAS was stopped and the patient's blood glucose concentrations became normal.


We describe the development of severe lipoatrophy in a patient treated with biphasic aspart.


We underline the association between this pathogen and inguinal skin breaks, and discuss the potential diagnostic pitfalls in clinical and laboratory diagnosis.


We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.


Endogenous catecholamines in excess are known to cause dilated cardiomyopathy.


Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridine.


The overall tolerability was considered to be very good; however, initial sleepiness appeared in four patients.


An 82-year-old woman with type 2 diabetes had been treated with recombinant human insulin for 16 years.


The hospital course of the acute renal failure is presented with a review of the literature on cases of acute renal failure after IVIG.


These asymptomatic papules with a tendency to coalesce became more prominent with prolonged exposure (Figs 1 and 2).


The objective of this presentation is to document the salient clinical findings in a case of aflatoxicosis and to review the literature on the same so as to increase the index of suspicion, enhance early diagnosis and improve management.


Hyperhidrosis is a debilitating condition characterised by sweating that exceeds the need of normal thermoregulation.


BACKGROUND: Chronic pain is one of the most common reasons for therapeutic cannabis use.


Generalized and partial complex seizures, other neurological signs and symptoms, and laboratory data were improved after modification of her anticonvulsant regimen.


Potential advantages and hazards of transvaginal intratubal insemination and single-dose MTX for ectopic pregnancy are discussed.


Nail staining from hydroquinone cream.


Case report: severe gastrointestinal inflammation and persistent HHV-6B infection in a paediatric cancer patient.


It is concluded that boldo leaf extracts might be hepatotoxic, at least in elderly patients with fatty liver.


Linezolid, the first approved oxazolidinone, appears to be a promising new agent for the treatment of serious Gram-positive infections.


Her serum creatinine phosphokinase level was 19,190 IU/L.


Very elderly patients with nephrotic syndrome frequently suffer from oliguric renal failure, which has a potentially high mortality.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Laboratory studies demonstrated eosinophilia, elevated serum IgE, and elevated T suppressor/cytotoxic cells in the peripheral blood.


Arterial hypotension, which improved with inotropic agents, was the only complication that seemed related to the inhaled anaesthetic.


Renal biopsy showed a type I membranous glomerulonephropathy.


After the chlorambucil was discontinued, the wbc count began to slowly rise and the patient developed clinical AML.


He was maintained on cyclosporine A, mycophenolate mofetil, and prednisone.


We describe the case of a 10-year-old girl with two epileptic seizures and subcontinuous spike-waves during sleep, who presented unusual side-effects related to clobazam (CLB) monotherapy.


We do not suggest that epidural steroid therapy is the treatment of choice for patients with multiple back operations or that it is efficacious for these patients.


Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme in the catabolism of 5-FU.


Neuropathies masquerading as an epidural complication.


Her serum calcium level was finally stabilized in the 2.37-2.95 mmol/L by administration of a single intravenous dose of pamidronate.


Hematologic toxicity was mainly granulocytopenia, but thrombocytopenia occurred in two patients.


Complementary examinations and follow-up disclosed a sarcoidosis.


Ifosfamide is an alkylating agent used in the treatment of a variety of solid tumours.


Two patients had a predominantly axonal and sensory polyneuropathy of the lower legs with fasciculations in one of them.


A case of stage 4 neuroblastoma that developed excessive hypertension on day 120 of chemotherapy is presented.


Cross-sensitivity reaction between tacrolimus and macrolide antibiotics.


Isoniazid-induced anaphylaxis.


The case of a 67-year-old man with acute myocardial infarction with ST-segment elevation after a wasp sting treated with fibrinolysis and without significant coronary atherosclerosis is reported.


We followed these patients by A scan ultrasonographic ocular measurements, documenting reduction of the anterior chamber depth combined with lens thickening.


Exposures to 4-hydroxycyclophosphamide, the combination of thiotepa/tepa and carboplatin were 94%, 117% and 71% higher than the median respective exposures in a non-obese population of patients ( n=24) receiving similar doses.


Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.


Hypercalcemia occurs frequently after renal transplantation.


The patient was sent to a rehabilitation hospital and had a partial recovery.


A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.


We present the case of a nine-year-old boy with hypoplastic left heart syndrome and immune thrombocytopenic purpura who subsequently developed pneumatosis intestinails with a benign clinical examination.


Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.


Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.


We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.


Thalidomide neuropathy in childhood.


Administration of multiple doses of meperidine in patients with hepatic disease should be discouraged.


Glucocorticoids may be useful as short-term palliative therapy for acute exacerbations of Crohn disease.


There were a small number of damaged follicles infiltrated by macrophages, which were immunopositive for HAM56.


Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.


A 46-year-old man began taking nicotinic acid, 3 g daily, for hypercholesterolemia.


The syndrome is characterized by hyperuricemia, hyperphosphatemia, hypocalcemia, hyperkalemia, and acute oliguric or anuric renal failure due to uric acid precipitation within the tubules (acute uric acid nephropathy) and to calcium phosphate deposition in the renal parenchyma and vessels.We report a case of acute spontaneous TLS in a patient with Crohn s disease treated with immunosuppressive drugs, who developed a plasmocytoma, in which serum uric acid concentration attained exceptionally high levels (44 mg/dL).


In the last years intravenous cyclosporine (CyA) has been reported to be rapidly effective and relatively safe in patients with severe corticosteroid-resistant UC.


A case of normotensive scleroderma renal crisis after high-dose methylprednisolone treatment.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Dapsone syndrome in cutaneous lupus erythematosus.


For 4.5 months after surgery, the bird had no recurrence of clinical signs; however, dyspnea recurred and during evaluation, the bird died.


Our patient illustrates the importance of early recognition and treatment of hyponatremia before the onset of seizures.


Phytonadione 10 mg was administered subcutaneously, and warfarin was held for 3 days until her INR fell to 2.10.


A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.


In one case, PVT occurred in the absence of HVOD in a patient with pre-existing periportal lymphomatous infiltration.


A novel side effect of antithyroid drugs.


Although all patients recovered, hemodialysis hastened the rate of recovery.


Patients with TSHoma-associated autoimmune thyroiditis should undergo careful follow-up for development of Graves' disease after treatment.


Two manic-depressive patients are described who presented with acute renal failure and concurrent lithium toxicity.


The prognosis is generally poor for patients who experience a cardiac arrest.


A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias.


As the prevalence of human immunodeficiency virus (HIV) infection continues to rise the clinician is encountered with a diagnostic challenge.


Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.


Gabapentin may act directly upon temperature regulatory centers.


We report the case of a 30-year-old male after kidney transplantation, treated with steroids, cyclosporin A and SRL, with steroid-resistant acute rejection in anamnesis.


Periodic alternating nystagmus generally implies structural brainstem disease, especially at the craniocervical junction.


The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.


We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.


This case demonstrates that both epoetin alfa and darbepoetin alfa may artificially lower A1C levels in a patient with diabetes who is not undergoing dialysis, and therefore this finding can be interpreted as a class effect.


Homozygosity for the methylentetrahydrofolate reductase (MTHFR) C677T polymorphism diagnosed by molecular genetic analysis was the only explanation for this toxicity.


Six days after starting acyclovir she exhibited signs of lithium toxicity.


Corticosteroids may be useful for therapy of some features of this syndrome, such as thrombocytopenia.


Following treatment, that behavior also ceased.


The other evaluable patients showed stable disease with improved symptoms.


An adult female with developmental disability was prescribed chlorpromazine for the target behaviors of aggression and self-injurious behavior (SIB), and she was prescribed phenobarbital for seizures.


Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.


Adenosine is used as pharmacological treatment of the first choice for the termination of regular small complex tachycardia.


Chest roentgenogram showed interstitial congestive failure, and an EKG demonstrated sinus bradycardia.


However, these drugs have different toxicity profiles and may have clinically relevant differences in immunosuppressive activity in individual patients.


Respiratory effects of halothane in a patient with refractory status asthmaticus.


A 48-year-old woman with a diagnosis of breast carcinoma was treated with adjuvant chemotherapy through a central venous catheter with subcutaneous reservoir (Port-A-Cath).


Chronic traumatic trigeminal neuralgia.


Bleeding occurred into the gastrointestinal tract in four patients, into the kidney-urinary tract in three patients, into vascular surgical sites in two patients, and one each into the pulmonary-bronchial and cerebral-ventricular systems.


It is too early to evaluate four patients at present.


The lesions were determined to be a phaeohyphomycosis, caused by Curvularia lunata.


On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.


Herbal product use in a patient with polypharmacy.


Twenty days after cessation, cortisol concentrations were undetectable again.


CONCLUSION: Overnight wearing of a rigid contact lens is a risk factor for a corneal ulcer.


At 4-y follow-up, her condition is good.


Successful treatment of bronchiolitis obliterans organizing pneumonia with low-dose methotrexate in a patient with Hodgkin's disease.


A 28 year-old man with chronic hepatitis B was administered interferon-alpha (5 x 10(6) IU) intramuscularly once a day for 28 days.


We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.


A computed tomography scan revealed a large mass, 12 cm x 7 cm, involving the scalp extending from the right temporal region to the vertex.


The patient's mental status returned to baseline after treatment with intravenous phenytoin and discontinuation of ifosfamide therapy.


Potential mechanisms regarding the pathophysiology of lithium-associated CDI are discussed.


The potential autoimmune complications of this therapeutic agent should be comprehended when monitoring patients receiving such treatment.


In renal transplant recipients it has previously been related to immunosuppressive treatment with cyclosporine.


A year later, the patient reported complete disappearance of pain and swelling, although right breast continued to appear larger than the left.


Immunoelectron microscopy of perilesional skin revealed IgA deposits within the lamina lucida and immunoblotting of the patient's serum disclosed IgA and IgG antibodies directed against epidermal antigens of 280, 165 and 120-130 kD.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


This prompted a study of the effect of an eight week course of haloperidol (HAL) followed by two week withdrawal, on dopaminergic neurons of the substantia nigra in rats.


Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.


The effect of oral dissolution therapy for pancreatic stones was evaluated in patients with chronic calcific pancreatitis.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


The respiratory effects of morphine and the particular risks posed to the elderly patient are discussed.


This is the earliest onset PCP in the literature after HSCT despite the prophylactic administration of TMP/SMX before transplant.


We describe the clinical course, renal function, serial renal histology and urine and blood viral load measurements in two consecutive patients with refractory BKVN who were treated with low-dose cidofovir (0.25 mg/kg IV).


Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.


However, the pathogenesis of this association is not fully understood.


Pneumocystis carinii (P. carinii) is one of the major opportunistic pathogens responsible for hematopoietic stem cell transplantation (HSCT)-related pneumonias.


In the second block of the consolidation phase, 10 hours after triple intrathecal treatment, we realized that instead of 12 mg, 120 mg of methotrexate had accidentally been given.


The patient presented with widespread medial calcification involving various small to medium sized arteries, although no noticeable secondary hyperparathyroidism was observed.


Two patients had a poor outcome, 1 patient suffered a significant groin hematoma, and there were no instances of symptomatic intracerebral hemorrhage.


Reported cases include probable pulmonary TB (1), pneumocystis pneumonia (1), other pulmonary infection (2), and septicemia (3) including a case of infective endocarditis.


Lithium interferes with reserpine-induced dopamine depletion.


Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.


Patients were treated at a healthcare facility in 160 cases, with 79 patients admitted.


Infracardiac total anomalous pulmonary venous connexion and unilateral renal agenesis with ipsilateral phocomelia and unicornuate uterus were associated anomalies.


Despite their effectiveness, anti-TNF drugs have some drawbacks such as severe adverse effects including infections and possibly lymphoproliferative disorders.


Phototesting with artificial light sources did not have any effect on the DSP lesions.


Polymyositis, however, has never been reported immediately after treatment for active hyperthyroidism.


Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.


This observation suggests that long-term solvent exposure may trigger MF and hasten its progression from the patch stage to the plaque and tumour stages.


The etiology of neurotoxicity in our two patients remains unclear; however, as CAP is rapidly metabolized to 5-FU in patients with normal liver function, it is likely that 5-FU or its active metabolites (fluoro-beta-alanine) were contributing factors.


Regular surveillance of the patient detected a 3.5 cm HCC lesion.


BACKGROUND: An osteogenic sarcoma of the skull is rare, particularly as a primary tumor.


Ganciclovir is a nucleotide-analogue similar to acyclovir, which has an in vitro activity against herpes simplex type 1, herpes simplex type 2 and varicella zoster virus.


A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.


METHODS: A 70-year-old woman with bilateral normal tension glaucoma was treated with topical brimonidine and followed in an outpatient setting.


CASE REPORT: A 47-year-old woman presented with a spontaneous sternal fracture, precluding effective coughing.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


DISCUSSION: As of February 11, 2004, this is the first case, to our knowledge, to describe the use of oral terbutaline therapy for chronotropic support in the setting of acute rejection after heart transplantation.


Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review.


The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before.


Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.


From these findings, we determined his transfusion-resistant cytopenias to be attributable to HPS.


The patient's hemoglobin decreased from 12.7 to 8.5 g/dL and he received a 3-unit blood transfusion.


Ishihara color plates showed normal color vision.


The stimulation indices of the drug-induced lymphocyte stimulation test (DLST) for AZA in these two patients were as high as 2,180% and 430%, respectively, but those of healthy volunteers were under 120% without nonspecific suppression of lymphocyte proliferation.


Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate.


We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis.


Magnetic resonance spectroscopy in Niemann-Pick disease type C: correlation with diagnosis and clinical response to cholestyramine and lovastatin.


Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.


The pathogenesis, through retrograde spread of superficial infection to durocortical veins, is discussed in the light of serial CT scans at different stages of formation and treatment of the abscess.


Hyponatraemia during low-dose carbamazepine therapy.


Furosemide, spironolactone, hydroxyurea, allopurinol, and docusate were all reintroduced without reactivation of the lesions.


Pulmonary capillaritis has been described in adult lung transplant recipients, but has not been previously reported in pediatric recipients.


Acute cervico-facial oedema and loss of consciousness following ingestion of barracuda fish.


The manual intravenous push has a greater possibility of inadvertent overdosage during some small time frame, as well as more local symptoms by some reports.


First-trimester pregnancy exposure can cause major birth defects.


Ulcerating enteritis associated with flucytosine therapy.


MATERIAL AND METHODS: A 39-year-old male with idiopathic sudden SNHL that was responsive to corticosteroids was treated with ciclosporin for 18 months.


Three years later, she complained of mild visual loss in the right eye.


A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).


Cytogenetic studies revealed an abnormal karyotype with deletion of the long arm of chromosome 11 (11q21) and 2 additional copies of the MLL gene attached to the short arms of chromosome 10 in 80% of the metaphase cells examined.


This case demonstrates that TZDs may precipitate weight gain and pulmonary and peripheral edema in patients with stable heart failure.


We report a case of hip fracture during treatment which was associated with osteoporosis.


Gemcitabine should be added to the list of drugs known to cause radiation recall.


We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.


Hair loss associated with paroxetine treatment: a case report.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Diabetes mellitus and exocrine pancreatic insufficiency in a girl with auto-immune haemolysis.


Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.


N. sicca should be considered as a possible pathogen in CPD-associated peritonitis.


Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation.


An electrocardiogram revealed occasional premature ventricular contractions, a QTc interval of 683 msec (normal range for females 450-460 msec), and R on T phenomenon.


Eleven of 37 patients developed abnormal PT and/or PTT.


An association between NCPH and patients infected with human immunodeficiency virus (HIV) has been reported.


This was suggestive of type I hypersensitivity reaction.


Radiographic studies demonstrated a focal, space-occupying lesion in the spinal canal at the level corresponding to the neurologic deficit, which spontaneously resolved over the next 2-3 h.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


Endoscopy demonstrated oesophagitis and a benign oesophageal stricture.


The patient locked his catheter with 2.0 ml every evening for a period of 5 days.


Metformin-associated lactic acidosis precipitated by diarrhea.


The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.


Complications in the use of prochlorperazine.


Nephrotic syndrome associated with lithium therapy.


This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.


On admission she was unconscious with absent brainstem reflexes and multifocal stimulus-sensitive myoclonus.


RESULTS: Discontinuation of corticotherapy led to anatomic and visual improvement.


We report a fatal intoxication in a 59-year-old woman who had uremia undergoing hemodialysis, and then took amantadine and pramipexole for Parkinsonian tremor.


We review the literature and discuss its pathogenesis.


This may lead to misdiagnosis as migraine and delayed appropriate diagnosis and treatment.


Monsel's solution can be used therefore if other conventional methods were applied unsuccessfully to stop the uterine hemorrhage.


Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.


No chimeric glomerular cell was detected.


However, progression to overt cardiac failure has only recently been reported in one patient with pre-existing heart disease.


Safety of electroconvulsive therapy in psychiatric patients shortly after the occurrence of pulmonary embolism.


In the following case report, a patient developed acute interstitial nephritis with renal failure and exfoliative dermatitis following ampicillin therapy.


The number of suspected ADRs remains small, especially when compared with the magnitude of human clinical use of 1% lindane preparations in the United States (50 million ounces during the past five years).


The treatment of choice remains operation.


DISCUSSION: Gabapentin is widely used in the management of pain.


Emergent conduit revision with cardiopulmonary bypass was required for a thrombosed systemic-venous to pulmonary-arterial connection (completion modified Fontan procedure).


After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.


CONCLUSION: Infectious retinochoroiditis is a potentially blinding complication seen after cardiac transplantation, justifying close clinical and serological surveillance or, in certain cases such as mismatched donors, anti-parasitic prophylaxis.


In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.


Multiple reports in the last decade have shown increased mortality and increased utilization of resources in patients who received catheterization of the right side of the heart.


We report two cases of septic knee arthritis.


RESULTS: The patient had complete paraplegia develop within 12 hours from admission following a 1-day history of unsteady gait and a 3-day history of leg numbness.


The ROTEM analysis strongly suggested the presence of either a heparin effect or severe deficiency of coagulation factors.


The case reported here illustrates that clinicians should be aware of this potentially fatal drug reaction.


Recent trends in the treatment of acute paracetamol poisoning are mentioned.


Tetracycline-induced benign intracranial hypertension.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Three months following splenectomy, multiple abscesses occurred in the muscles of both thighs while the patient was receiving the third course of the CHOP regimen.


Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.


She used to move her right hand over the right eye while simultaneously rubbing the forehead since the age of 8.


However, we report the case of an 88-year-old woman who was treated for prosthetic joint infection and methicillin-resistant Staphylococcus aureus bacteremia with vancomycin followed by linezolid therapy.


Eighty-two patients with various malignancies who received imipenem/cilastatin 143 times for neutropenic fever between March 1994 and October 1999 in Department of Pediatric Oncology, Gazi University, were identified.


In the first case oligo-anuric renal failure occurred on the thirteenth day of treatment, after the patient had taken only 9 doses of medication.


We enrolled eight out of 155 patients with advanced melanoma in a multicentre phase II trial that evaluated the activity and tolerability of ipilimumab, a fully human, anti-CTLA-4 monoclonal antibody ( www.clinicaltrials.gov ; NCT00289627; CA184-008).


Two cases are presented that illustrate a possible treatment role for ECT.


We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels.


Given tardive dyskinesia (TD), clinicians and interdisciplinary teams should remain alert to the following client profile: (1) prescribed phenobarbital (or primidone), (2) prescribed neuroleptics, especially at high dosages, to control maladaptive behaviors, (3) failure of neuroleptic gradual minimal effective dose attempts, and (4) possible presence of behavioral procedures, especially intrusive procedures, to control maladaptive behaviors.


Both patients suddenly became hypotensive after injection of chymopapain into a disk.


These situations must be recognized as potential problems and must be treated appropriately.


Symptoms mimicking Crohn's disease deteriorated under intensified immunosuppression and surgery.


Toxicological analysis of the blood revealed GHB 165.6 mg/L, and 90.7 mg/L in the urine.


The overall response rate of these 24 refractory lymphomas to gemcitabine-containing regimens was 46%.


However, 8 hrs after extubation, she gradually developed severe respiratory distress, requiring reintubation and mechanical ventilation.


Chinese and African populations.


Two months after the incident, the choroid was normal appearing but the pars planitis was unchanged.


Diagnostic criteria are GI symptoms, eosinophilic infiltration proven by biopsy of the GI tract, and absence of parasitic infection.


Antiasthmatic medications were prescribed, but the asthma symptoms did not improve.


Clinical characteristics of the corneal infiltrates resembled staphylococcal-immune infiltrates.


The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.


The clinical and laboratory findings in two cases of aerobic Corynebacterium Group JK infection of cerebrospinal fluid (CSF) shunts are described.


1. Nine patients in whom acute non-lymphoblastic leukemia (ANLL) developed following prolonged alkylating agent therapy are described.


But if necessary, when deciding which agent to use, the clinician should consider the mechanism by which the body clears TNF-alpha.


We hypothesize that caffeine toxicity injured the muscle cells, which were fragile due to the potassium depletion induced by the coexisting hyponatremia, to result in unusually severe rhabdomyolysis.


Compared to patients without TD, patients with TD had a long duration of illness and clozapine treatment; all had the orolingual type of TD.


Rarely, it can rupture, resulting in peritonitis and gram-negative sepsis.


Treatment of severe lactic acidosis with dichloroacetate.


Patient B developed perioral and upper extremity paresthesias during the fourth cycle of CAP alone (2500 mg/m2).


A 6-year-old boy received renal transplantation and was treated with methylprednisolone, cyclosporine A and mizoribine.


CASE REPORT: Two of our patients with history of ingestion of carbamazepine were tested positive on screening with the tricyclic antidepressant immunoassay.


CASE SUMMARY: A 71-year-old woman with a history of malignant mixed mesodermal tumor involving the uterus, cervix, and vagina was admitted because of local recurrence.


Intravenous azithromycin-induced ototoxicity.


The favourable influence of PCS on the depressive syndrome is considered to be largely linked to the anticholinergic effect of the drugs.


Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.


A 77 year old male was referred with abdominal pain, jaundice and elevated transaminase levels.


In four eyes, the RPE tear developed after one PDT, in one eye the RPE tear developed after the second PDT, and in two eyes the RPE tear developed after the third PDT.


Long-term treatment in gut neuroendocrine tumours, efficacy of oral administration, and possible use in non-tumoural inappropriate TSH hypersecretion.


If there are inconsistencies between levothyroxine products, resultant deleterious effects on the therapeutic stability of patients with hypothyroidism may undermine cost savings that might be incurred by such a change.


These results suggest the feasibility and effectiveness of multicyclic DI-CT and the usefulness of ABPCT as a treatment option for relapsed SCLC.


However, as with botulinum toxin type A (BTX-A) it has off-label uses, such as for hyperhidrosis, focal dystonias, spasticity, and facial wrinkles.


There was no family history of similar lesions.


Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism.


At 16th month after transplantation, elevation of serum aminotransfereases was observed.


At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.


Histological examination of the dacryolith suggested its derivation from breakdown products of adrenaline.


Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.


Aminoglycoside-induced renal tubular dysfunction could result in diffuse damage or manifest as a Fanconi-like syndrome, Bartter-like syndrome, or distal renal tubular acidosis.


The risks of sumatriptan administration in patients with unrecognized subarachnoid haemorrhage (SAH).


CASE PRESENTATION: Three cases of Leishmania infantum leishmaniasis in corticosteroid (CS)-treated patients are reported: an isolated lingual leishmaniasis in a farmer treated with CS for asthma, a severe visceral leishmaniasis associated with cutaneous lesions in a woman with myasthenia gravis, and a visceral involvement after cutaneous leishmaniasis in a man receiving CS.


Phenytoin-induced hypersensitivity reactions.


In our case no complications developed from the treatment and the patient's visual loss and renal function improved.


Posterior circulation hyperperfusion syndrome after bilateral vertebral artery intracranial stenting.


Radiation myelopathy is a rare, devastating, late effect of radiotherapy to the spinal cord.


In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.


We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.


This shows that sertraline has potent interactions with lamotrigine metabolism.


As of December 1998, only mild ectropion persisted.


One patient received moxalactam as part of the combination therapy for diffuse pulmonary infiltration during renal transplant rejection.


These preliminary data suggest that low-dose cidofovir may be tolerated, even among renal transplant recipients with significant renal dysfunction due to BKVN.


Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.


Glutathione levels were low before treatment, and increased during treatment.


RESULTS: The treated rabbit eyes and the control eyes showed no light microscopic evidence of ocular toxicity at 1 month following injection.


Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.


The patient was intubated with ventilator support and improved after his metabolic acidosis resolved.


Four years after the beginning of IFN therapy, he acutely developed moderate hyperglycemia and severe ketonuria with positive islet cell antibody, and then 28 units/day of insulin injection was started.


Chronic cystoid macular edema that does not respond to topical nonsteroidal antiinflammatory drops may resolve with intravitreal triamcinolone but not with bevacizumab.


A possible mechanism for focal neurological deficit in brain-damaged patients on phenytoin therapy is discussed.


Pancreatitis is a very rare adverse effect associated with the use of amiodarone, and only four cases of amiodarone-induced pancreatitis have been reported in literature.


Magnesium sulfate, a saline laxative, is often used for treatment of intestinal impactions in horses.


One complication is toxic leukoencephalopathy, which is due to a direct toxic effect of chemotherapeutic agents on the central nervous system white matter.


The authors present a case study of a mentally healthy man who repeatedly experienced short-lived, obsessional-like suicidal ideas and images after ingestion of the anti-fungal drug ketoconazole.


Screening for celiac disease with detection of anti-endomysium antibodies would be done in susceptible patients.


Acute left atrial thrombosis during anticoagulant therapy in a patient with antithrombin deficiency.


Severe flare-up in a prostate cancer patient treated with luteinizing hormone-releasing hormone analogue depot.


Risk of abuse of diphenhydramine in children and adolescents with chronic illnesses.


These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.


Nephrotic syndrome in strongyloidiasis: remission after eradication with anthelmintic agents.


CONCLUSIONS: Choroidal detachment can occur in surgically untreated eyes after use of a topical carbonic anhydrase inhibitor.


Pathological features and a considerable improvement in myocardial function after withdrawal implicated the exogenous catecholamine excess in the pathogenesis of the cardiomyopathy.


Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.


Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.


We propose that the reactions may represent local manifestations of heightened delayed hypersensitivity, mounted by increasing numbers of 'resuscitated' lymphocytes against immunogenic cell wall substances released from dying tubercle bacilli in patients whose level of cellular immunity is being enhanced as a result of chemotherapy.


MATERIAL AND METHODS-A 50-year-old woman was followed-up for 15 years clinically and paraclinically after a heavy PHT intoxication.


This patient, a 29 year old male, suffered from grand mal epilepsy for about 12 years, and he had been treated with anticonvulsive drugs.


In the previous four patients treated with cidofovir the outcome was discouraging, as was the case in this patient.


Recombinant factor VIIa has been licensed in the United Kingdom since 1996 for the control of bleeding in hemophilic patients who are actively bleeding or are about to undergo surgery.


Ulcer became worse after tobramycin and gentamycin treatment for 2 days.


Despite this, the lesions worsened in severity.


Very few cases of rituximab administration during pregnancy have been described.


Reversible cardiomyopathy caused by administration of interferon alpha.


Sudden death in an infant from methemoglobinemia after administration of "sweet spirits of nitre".


Ceftriaxone-induced fixed drug eruption: first report.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


One patient with a chromosome 22q11.2 deletion and Evans syndrome is reported in this paper.


A case report.


These pauses were always preceded by the short P-P intervals and were usually followed by one or two P-P intervals of 0.92-0.95 s representing the basic sinus cycle.


(4) The acute rehabilitation of a 21-year-old woman with systemic lupus erythematosus and a history of 14 laparotomies due to severe acute pancreatitis and multiple gut perforations.


At a six-month follow up, her skin lesions improved and there was no recurrence of neurologic symptoms.


During this time, she was exposed to chickenpox.


Fatal complication of intravesical formalin during control of intractable hemorrhage from radiation cystitis.


Our study presents a new aspect of the benefit of STN stimulation with regard to drug-induced non-motor symptoms in patient with PD.


Triglyceride levels decreased from 1450 to 337 mg/dl (76.8%) and from 1985 to 322 mg/dl (83.8%), respectively, after 10 months of therapy.


A 5-year-old boy presented with abdominal pain, nausea and vomiting of blood.


Narcolepsy, paranoid psychosis, and analeptic abuse.


Constrictive pericarditis has been defined classically as a progressive condition, characterized by pericardial fibrosis, with or without calcification, which results in chronic refractory congestive heart failure and for witch pericardiectomy is often required.


Gastric candidiasis.


Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.


This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.


The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.


The development of nephrotic-range proteinuria after renal transplantation is an unfavourable prognostic factor for graft survival.


She subsequently haemorrhaged into the infarcted area with residual neurological deficits.


Recovery occurred within 2 months with supportive treatment.


RESULTS: The study patients were observed up to 4 years, and none of them reported any problems.


Computed tomography (CT) of the brain showed only mild right-sided hydrocephalus, and was negative for intracranial hemorrhage and intracranial mass.


However, after a few months of treatment, apomorphine was ineffective in stopping abnormal movements, even when doses were increased.


The management of further bleeding in these patients is difficult.


We describe the development of methicillin-resistant Staphylococcus aureus osteomyelitis of the scaphoid in a 49-year-old man from an infection occurring around a catheter in the radial artery.


Retinal dysfunction and anterior segment deposits in a patient treated with rifabutin.


The restrictive lung disease progressed despite cessation of sulfasalazine and initiation of corticosteroid therapy.


We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both.


Pamidronate treatment of hypercalcemia caused by vitamin D toxicity.


This case illustrates that a small number of subjects with severe asthma receiving high-dose CS need to be considered as a separate, high-risk group for developing disseminated varicella.


MEASUREMENTS AND MAIN RESULTS: A 37-yr-old female with recently diagnosed acute myelogenous leukemia was admitted to the ICU with mental status changes and progressive dyspnea requiring intubation and mechanical ventilation.


Jaw osteonecrosis associated with use of bisphosphonates and chemotherapy: paradoxical complication of treatment of bone lesions in multiple myeloma patients.


Medical treatment was continued for 6 mth.


A presumptive diagnosis of severe bronchospasm was made, and aggressive bronchodilator therapy was instituted.


Several recent series have suggested that, in most cases, CMV reactivation does not lead to severe complications and resolves spontaneously with the UC flare and discontinuation of immunosuppression.


Thrombolytic therapy with tissue plasminogen activator (tPA) for acute myocardial infarction may result in major bleeding complications such as gastrointestinal or intracranial bleeding.


Black cohosh and other herbal remedies associated with acute hepatitis.


Serum creatinine increased to 6.1 mg/dL on day 4 of admission from a baseline of 1.0 mg/dL.


Flutamide withdrawal syndrome is characterized by a decrease in prostate-specific antigen (PSA) after flutamide withdrawal in a subset of patients with progressing metastatic carcinoma of the prostate.


Eleven milliliters of clear yellow fluid was collected via abdominocentesis.


We report a case of fulminant MH associated with a ketoacidotic diabetic coma.


To our knowledge, broken heart syndrome after opioid withdrawal has not been reported previously in an adult.


Some aspects of DEM overlap with neuromyelitis optica (NMO), another demyelination disease of CNS that was for a long time regarded as part of the MS spectrum, until discovery of the aquaporin-4 antibodies, claimed to be specific for NMO.


A diagnosis of masked theophylline poisoning should be considered in similar situations involving a rapid decrease of insulin requirements.


Intravenous injection of diazepam caused a rapid normalization of the EEG with disappearance of the clinical manifestations.


Case report and literature review.


A coronary arteriogram five hours after the onset of symptoms revealed total occlusion of the left anterior descending coronary artery.


This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.


Treatment of the chorea led to rapid resolution of her psychiatric symptoms.


Although rare, there have been reported cases of primary cutaneous T-cell lymphoma occurring in this population.


At the onset of the ST elevation, all patients were receiving dopamine infusion, which in four of them was inadvertently increased shortly before the ECG changes, the ST elevation was not associated with chest pain, pericardial friction rub, or acute changes in the heart rate, or arterial blood pressure.


Within minutes, he experienced an adverse reaction consisting of bilateral pruritus of the feet, which quickly progressed to his head; diaphoresis; nausea; vomiting; facial pallor; and hives.


In case of normal endometrial cells in the Pap smear, a careful evaluation should be performed.


The presentation and progression of drug-induced ocular cicatricial pemphigoid can be variable.


Torsade de pointes associated with moxifloxacin: a rare but potentially fatal adverse event.


This patient was using industrial strength glue to reattach a chipped tooth for approximately 1 year, and such use was associated with chronic exposure of his oral mucosa to this glue.


PURPOSE: To report a new adverse effect related to treatment with bimatoprost.


Interferon-induced psychosis as a "psychiatric contraindication" to hepatitis C treatment: a review and case-based discussion.


Neurological presentation of Wilson's disease in a patient after liver transplantation.


The isolate was resistant to amphotericin B in vitro, and the patient was successfully managed with surgical debridement and the recently licensed antifungal agent caspofungin.


METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.


The possible cause could be rebound enlargement after initial atrophy caused by these drugs.


Within weeks of initiation of baclofen treatment, the hiccups ceased.


Aluminum infusions should be used with caution in patients with renal failure.


Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.


Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.


It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.


This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.


When rechallenged with the same drug 6 months later, he developed hypothyroidism.


Antifungal therapy was given but her condition deteriorated and she died.


Its prevalence in rheumatoid arthritis (RA) has been estimated from several retrospective and prospective studies to range from 0.3% to 18%.


Perhaps rashes during infectious mononucleosis in association with other antibiotics are actually more common, but just not recognized.


Serial serum lithium levels were also obtained.


Central venous catheters deliver life-prolonging medications to Group IVC AIDS patients.


The basis of the temporal dissociation of serum lithium levels from the clinical manifestations of lithium intoxication remains uncertain.


On December 24, serum CK was 839 IU/L and myoglobin was 91 U/L and the patient was discharged.


However, an intradermal test was positive to cloxacillin (2 mg/ml) in case 2.


Because thrombolysis of giant thrombi may be ineffective, patients in this situation may require surgery.


Tumors shown to produce peptides other than gastrin, for example ACTH, were found to be markedly resistant to the action of SMS and continued to grow in an unbridled manner.


Herbal remedies are commonly used for psychiatric problems, but there is virtually no data about the use of these substances by young persons or by patients in treatment.


The sensory overload is treatable with oral potassium gluconate, with onset of the therapeutic effect in approximately 20 minutes.


Autopsy demonstrated extensive necrosis of the tumor mass, as well as necrotizing vascular damage within the neoplasm.


Brugada syndrome whose ST-segment changes were enhanced by antihistamines and antiallergenic drugs.


Since the corneal keratinization clinically improved with conservative management, surgical intervention was not required.


OBJECTIVE: To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain.


Isonicotinic acid hydrazide induced anagen effluvium and associated lichenoid eruption.


Essential thrombocythemia is characterized by increased incidence of thrombosis with arterial event more than venous events and hemorrhagic complications.


We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.


Celiac disease onset after pegylated interferon and ribavirin treatment of chronic hepatitis C.


Panhypogammaglobulinaemia is a rare complication of systemic lupus erythematosus (SLE), but its cause and mechanism are unclear.


This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.


A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension.


Toxicity occurred more frequently in those who received IM, and therefore high-dose, reserpine.


We report the case of an iatrogenically immunosuppressed patient who presented with a massive upper gastrointestinal hemorrhage that was caused by Kaposi's sarcoma of the stomach.


We describe a 63 year old woman with a suppurative mediastinitis, treated with continuous PI irrigation who developed an acute oliguric renal failure.


A report on two cases and literature review.


Immediate pain relief was accompanied by short lasting respiratory depression and drowsiness.


Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.


Pheripheral edema was observed in five female patients after taking proton pump inhibitors omeprazole, lansoprazole, or pantoprazole for 7-15 days for peptic acid diseases in recommended standard doses.


The primary goal is to identify and treat the underlying disorder, while minimizing the impact on hemoglobin (Hb) levels.


She presented the same symptoms after oral intake of metamizole.


A fifty-seven-year-old man with acute MI was admitted to the intensive cardiac care unit and received streptokinase and heparin.


This was not associated with hemorrhagic problems.


OBJECTIVE: To report a possible drug interaction between the combination of fluorouracil (5-FU), levamisole, and warfarin.


In late 2000, pulmonary symptoms developed.


Three patients (19%) required mechanical ventilation because of deep coma or shock and died within 6 hours.


The authors report a case of urinary incontinence (UI) that occurred in a woman after administration of venlafaxine.


The infection was treated successfully with systemic and intrathecal antibiotics without removal of the catheters.


The effect of SERMs on the endometrium.


The range of diagnostic possibilities is wide, noninvasive diagnostic procedures have little utility, and the drugs available for empirical therapy have toxic effects that are sometimes severe.


Linezolid treatment of prosthetic hip Infections due to methicillin-resistant Staphylococcus aureus (MRSA).