The markedly increased expression of fibrogenic factors PDGF-B and IGF-1 on hyperplastic alveolar macrophages and hyperplastic type II pneumocytes may play an important role in the fibrogenesis of this disease.


Approximately 1 to 2 minutes after injection, the patient described discomfort in the lower abdomen, and 1 minute later, he was unable to move his lower extremities.


Majocchi's granuloma of the face in an immunocompetent patient.


Our findings suggest the presence of coinfection with at least 2 different strains of CMV rather than induction of mutations after ganciclovir therapy.


In the absence of controlled studies regarding management of such cases, many recommend complete removal of the pacing system along with intravenous antibiotics.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


Preexisting hyperparathyroidism is the most common cause of post-transplantation hypercalcemia.


A frequent problem is relapse of disease when corticosteroid dosage is tapered off.


The case of a 31-year-old woman with headache, vomiting, generalized tonic-clonic seizure, and subsequent dense hemiplegia is presented.


Therefore, cidofovir was administered.


Linezolid is relatively well tolerated and is not believed to be nephrotoxic.


Characterized by sterile, intra-epidermal pustules located on the palms and soles, it is highly resistant to treatment.


Two patients, aged 44 and 68 years, presented with generalized seizures either witnessed or highly suspected.


Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection.


The plasma concentration of pilsicainide, although not measured, must have been very high, since his renal function was impaired.


This report describes the case of fungal sinusitis in severely immunocompromised 32-year-old male with common-type acute lymphoblastic leukemia who relapsed after autologous peripheral blood transplantation.


Quinine is universally used for the very common symptom of night leg cramps.


Steroid induced exophthalmos.


Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.


Cerebrovascular complications of L-asparaginase therapy in children with leukemia: aphasia and other neuropsychological deficits.


The anaphylactic reaction was managed successfully with corticosteroids, nebulization with beta(2) agonists, and isotonic fluid support.


On day 8 after alloBMT, the patient suddenly manifested high-grade fever, transfusion-resistant severe anemia, and thrombocytopenia.


Eight of the 12 events were subjected to vitreous tap and injection of antibiotics and steroids on the day of presentation.


A 43-year-old woman received cisplatin 60 mg/m2 in 15 minutes during her sixth cycle of therapy.


Streptokinase is the mainstream therapy for acute myocardial infarction.


On discontinuing the medication, the areas of severely restricted diffusion had entirely resolved, with minimal residual T2 signal abnormality.


Histopathology revealed classic nodular sclerosing Hodgkin's disease, without evidence of Epstein-Barr viral infection.


These patients may require protamine/NPH desensitization, an alternative insulin preparation, or both.


One patient had breast cancer with multiple distant metastasis and received palliative radiotherapy to the spine and hip joint.


After conventional therapy failed, the patient underwent treatment with adalimumab and the majority of his symptoms resolved after 16 weeks of therapy.


However, Strongyloides-related glomerulonephritis has not been well documented.


CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.


Efficacy was evaluated by the Clinical Global Impression Scale (CGI); safety by adverse events notes during the time mecamylamine was administered.


Somatostatin and its long-acting analogues are effective in symptom control in patients with functional neuroendocrine tumors; they are also able to control tumor growth.


One of them had a high pressure gradient of the left ventricular outflow tract and the others had earlier onset.


Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.


Identification of the BCG strain was performed in many sites, such as bone marrow, ganglionic mass, cerebrospinal fluid and in the site of vaccination.


Our patient also did not completely respond to these medications, but was successfully treated with cyclosporine alone.


The STAN-fetal scalp electrode system can record the fetal echocardiogram in labor.


Bradycardia, hypotension, respiratory distress, and, ultimately, cardiopulmonary arrest occurred in both.


An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.


Celecoxib can be administered as palliative treatment to affected birds, but as with any nonsteroidal anti-inflammatory drug, COX-2 inhibitors should be used cautiously because they can adversely affect renal function by decreasing renal prostaglandin synthesis.


In three patients, carbamazepine was withdrawn, whereupon the deposits disappeared in two and decreased in the third, who changed to another drug.


Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.


Four of the aviators were allowed to continue on active duty with limitations and one was disqualified.


Diffuse pulmonary infiltrates in immunocompromised patients.


Clinical findings included Horner's syndrome, generalized lymphadenopathy, temporal muscle atrophy, and chorioretinitis.


This case highlights many key points for treatment of psoriasis and psoriatic arthritis with biologics.


Finally, the MDSs are defined, classified and discussed with respect to their relevance to the clinical periodontist, from a diagnostic, therapeutic, and management standpoint.


An 8-year-old boy, treated with a short course of steroids for asthma, developed a fever with abdominal pain and a generalized vesicular rash after contact with varicella-infected classmates.


It should be noted that such an infection can occur in patients treated with conventional chemotherapy against malignant lymphoma.


A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.


Surgery was successfully performed after infusion of 112 microg kg-1 bw of recombinant FVIIa.


Radioisotopic control for baclofen pump catheter failure.


OBJECTIVE: To report the loss of therapeutic control in 2 hypothyroid patients and remind clinical pharmacists and other healthcare professionals to remain cognizant of possible product quality differences within or bioequivalency differences between levothyroxine products.


Although minor gastrointestinal bleeding is common among patients taking anticoagulants, all patients should be fully evaluated because the source of hemorrhage may be malignant.


Acute toxic delirium.


We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.


Venlafaxine was chosen (daily dose 75 mg) because this drug is claimed not to bind on muscarinic cholinergic receptors.


The blood specimens were initially subjected to a thorough qualitative analysis.


Newer therapies usually undergo closer scrutiny before being accepted, often including placebo-controlled trials to show the efficacy of a medication.


A positive reaction to sodium bisulfite in Tathion eye drops was confirmed.


In addition, the tachycardia persisted and was repeatedly spontaneously reinitiated for prolonged periods after procainamide.


The serum concentration of mast cell tryptase approximately 1.5h after the onset of the adverse incident confirmed an anaphylactic reaction.


No myeloma cells were found in the nervous system.


Abnormal vasopressin secretion was shown by a plasma vasopressin concentration of 0.5 microU/ml with a plasma osmolality of 268 mOsm/kg water after administration of a fluid challenge consisting of 45 ml/kg body weight.


Clinicians should be aware that myopathy can occur in patients with FMF who have normal renal and hepatic function.


We report the case of a 19-year-old woman who developed PVOD accompanied by microangiopathic hemolytic anemia (MAHA) and hemolytic uremic syndrome (HUS) 1 year after a second BMT for relapsed acute lymphoblastic leukemia (ALL).


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


We report the case of an adult patient affected by acute syncytial giant cell hepatitis which had a subfulminant course leading to liver transplantation.


Tinea incognito describes fungal infections with atypical clinical features and is usually caused by administration of steroids.


This review presents the first case series of DIC associated with acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP.


CONCLUSIONS: Chickenpox is not only a childhood illness.


This is the first case report of a Mycobacterium thermoresistibile infection following augmentation mammaplasty and is the fourth human case report of M. thermoresistibile infection.


Discontinuation of co-trimoxazole normalized serum potassium level and symptoms.


We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.


Topical tacrolimus appears as an effective and safe treatment of symptomatic OLP.


The evaluation of this case report leads to a comprehensive review in the treatment choice for menorrhagia with the preceding history of a thrombotic event.


Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.


We present a patient with chromoblastomycosis due to Fonsecaea pedrosoi, who was treated with 8 months of terbinafine 250 mg by mouth daily with histologic and mycologic cure.


Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.


A case of ovarian endodermal sinus tumor diagnosed during pregnancy.


RESULTS: Nine children presented with clinically significant lead poisoning.


A 34 year old man with an exacerbation of his colitis was diagnosed as having both cytomegalovirus colitis and hepatitis.


Sulfasalazine has been associated with bronchopulmonary complications of inflammatory bowel disease (IBD) in adults.


We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.


Acute leukemia following prolonged cytotoxic agent therapy.


The former patient had complained once that his visual acuity had decreased after the termination of IFN therapy, and the latter patient complained twice during IFN therapy that his visual acuity had decreased.


The keywords utilized were prostaglandin analogs, prostaglandins, prostamide, glaucoma, ocular hypertension, intraocular pressure, side effects, adverse effects, bimatoprost, latanoprost, lumigan, and xalatan.


A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.


Tonic seizures occurred immediately and appeared to represent a paradoxical seizure exacerbation.


Topical thiotepa treatment for recurrent corneal haze after photorefractive keratectomy.


Cholestyramine washout and prednisolone (60 mg/day) were given.


INTERVENTION: The LASIK flap was lifted or amputated, samples were submitted for Ziehl-Neelsen acid-fast stain and Lowenstein-Jensen's agar cultures for diagnosis; topical treatment with fortified clarithromycin and amikacin was administered until clinical resolution.


Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.


Fatal pulmonary fibrosis associated with BCNU: the relative role of platelet-derived growth factor-B, insulin-like growth factor I, transforming growth factor-beta1 and cyclooxygenase-2.


Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.


This gave almost total resolution of the injury.


The clinical features and cytogenetic changes of acute myeloid leukemia (AML) developing 10 years after radiotherapy and chemotherapy (for osteosarcoma) are described.


Larger series and double-blind studies, however, are necessary to confirm the initial results.


This case report describes the development of asymptomatic visual field defects (VFDs) in a psychiatric patient with bipolar disorder receiving adjunctive tiagabine treatment.


The liver status had been controlled by consecutive liver biopsies.


While a number of psychotropic agents may induce SIADH, only a few reports of tricyclic-antidepressant-induced SIADH exist.


Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.


The risk of cardiomyopathy in the setting of methylphenidate treatment should prompt further study on the safety of this drug, and lead to ways of identifying those at risk of developing these complications.


Dopamine dysregulation syndrome in Parkinson's disease: case report.


Changes in granulocyte or platelet counts were not observed.


We report an 82-year-old man who developed ventricular tachycardia and Torsades de Pointes (TdP) after oral administration of garenoxacin, a novel quinolone antibiotic agent that differs from the third-generation quinolones, for pneumonia.


An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.


Another serious complication associated with OHSS is thromboembolic events.


Our results suggest that patients with CLL in whom AML/MDS develops have similar prognoses to other patients with AML/MDS.


By comparing the length of the recurrence-free period following surgery alone with that following surgery plus perfusion in the same patients it was shown that perfusion treatment gave a significant extension of the recurrence-free time.


The latter two comprised a 42-year-old female with schizoaffective psychosis and a 35-year-old male with paranoid schizophrenia.


Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.


DIAGNOSIS: Fanconi syndrome with proximal (type II) renal tubular acidosis caused by myeloma kidney.


We also review DCL to emphasize the importance of recognizing and treating this evolving disease in the growing population of patients on immunorestorative therapy.


This case serves to highlight that rheumatic disease patients on steroids should be screened for GIO, as effective treatment and preventive measures are available.


It is well documented that cytotoxic treatment in patients carrying the hepatitis B virus (HBV) enhances the risk of severe hepatic damage.


As with any new therapy, we suggest waiting for the results of a randomized, controlled trial before recommending this treatment.


The neck ultrasonography revealed the presence of non-vascularized oval mass in the left submandibular area with an irregular sonostructure.


On suspicion of an adverse effect of carbamazepine, he was switched to phenytoin monotherapy.


To the authors' knowledge, this is the first report in the English-language literature of spontaneous neonatal intracerebral hemorrhage, due to thrombosis of the superior or inferior vena cava.


Mesenteric desmoid tumor in Gardner's syndrome treated by sulindac.


Generally, the administration of lamivudine has been well tolerated.


Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy.


Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.


Drug-induced aseptic meningitis (DIAM) is commonly seen with nonsteroidal anti-inflammatory drugs (NSAIDS), antibiotics (with TMP/SMX being the most frequently implicated), intravenous immunoglobulins and OKT3 antibodies.


Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.


The child developed a severe and florid form of mucocutaneous oral ulceration, severe ocular manifestations, along with marked constitutional disturbances and dehydration.


After clinical assessment undiagnosed chest pain can become a difficult problem.


In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.


The patient had complete recovery of neurologic function to his preoperative baseline after the second procedure but required a third procedure in which anterior discectomy and fusion at C4-C5 was performed, which led to improvement of his preoperative symptoms.


A case of SIADH associated with desipramine treatment in an elderly depressed woman is described.


Cytarabine-induced cerebellar syndrome: case report and literature review.


For patients on chronic maintenance PD who receive gadolinium, our case suggests that a temporary intensive automated PD regimen, aimed at maximizing clearance of this contrast agent immediately after exposure, could be an effective alternative when institution of HD is problematic.


Systemic cytomegalovirus infection complicating ulcerative colitis: a case report and review of the literature.


A 53-year-old black man was diagnosed with poorly differentiated adenocarcinoma of the lung and treated initially with 4 cycles of paclitaxel in combination with carboplatin and external-beam radiation therapy with a good clinicoradiologic response.


This case, along with extensive reports in the medical literature, illustrate how treatment with inhibitors of TNF-alpha has the potential to result in a wide range of infectious complications, including rapid growing Mycobacterium.


CONCLUSIONS: Serious lead poisoning continues to occur and there appears to be complacency regarding the hazard posed by lead paint in old houses.


The second patient exhibited sudden PLMS following olanzapine injection.


Aluminum intoxication from aluminum-containing phosphate binders in children with azotemia not undergoing dialysis.


METHODS: Hospital records at St.


After approximately two weeks of sertraline treatment he noted an intense itching sensation in his scalp after eating a piece of chocolate cake.


RESULTS: Among a total of 3,648 ICD-related procedures performed between 1983 and 2005, we identified 47 (1.3%) cases of ICD infections, of which 5 (0.1%) were due to a fungal pathogen.


Rectal biopsy analysis was consistent with pseudomembranous colitis.


Only 114 cases have been reported in the literature.


The fifth patient exhibited paraesthesia and agitation caused by olanzapine that was misdiagnosed as psychotic agitation.


The present preliminary report suggests that pharmacokinetic factors cannot be excluded and the CYP2D6 polymorphism is possibly associated with the etiology of NMS.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


Comparison of urinary levels of the porphyrin precursors, delta aminolevulinic acid and porphobilinogen, under controlled diet conditions before and after withdrawal of diphenylhydantoin, showed that this drug accounted for approximately one-half of the porphyrin precursor excretion.


Although several cases of solid tumours have been reported during TKI therapy, the link between cancer and TKIs is not yet clear.


Tacrolimus (FK506)-induced mutism after liver transplant.


Every effort should be made to avoid contact with mercury vapour if possible by using barrier techniques, reducing the temperature of the operating room and of the amalgam restoration.


We present 2 cases of patients with schizophrenia who manifested a catatonic syndrome and were indicated for ECT, along with antibiotic therapies for infectious diseases with piperacillin and cefotiam, respectively.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.


A teenage girl with crescentic glomerulonephritis had antineutrophil cytoplasmic antibody (ANCA) detected after she had received propylthiouracil (PTU) for hyperthyroidism without cutaneous vasculitis.


Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


CMV gastritis has been reported in transplant recipients.


Thrombocytopenia is one of the common manifestations of systemic lupus erythematosus (SLE).


The possible underlying neurotransmitter mechanisms, predisposing factors and clinical implications of this rare adverse event are discussed.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


Obese patients represent a unique group of patients in which TDM is extremely valuable in optimizing dosing, particularly in high-dose chemotherapy.


CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.


Integrating drug history, clinical morphology, clinical distribution, and histopathology can aid in the differentiation.


A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.


It must be considered as a potential source of cerebral hemorrhage in elderly patients undergoing thrombolysis for cardiac ischemia.


A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.


There are, however, well-known systemic side effects that may preclude continuation with these immunosuppressive therapies, and small trials of the anti-metabolite mycophenolate mofetil have been reported.


Coagulase-positive Staphylococcus aureus was cultured in the aspirate.


Discussion covers conjunctival carcinoma and behaviour of HIV-related tumours with antiretroviral therapy.


In this report, we describe a fatal gemcitabine-induced pulmonary toxicity in a patient with gallbladder metastatic adenocarcinoma.


Both were treated successfully with oral potassium.


Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.


PURPOSE: Eosinophilic jejunitis is a rare disorder of undetermined origin, which is characterized by infiltration of eosinophils in the intestine.


After 1 month of treatment, he was diagnosed as having acute renal failure secondary to HUS.


Both patients received prolonged treatment with high doses of intravenous methylprednisolone.


One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.


A 15 Year old female patient with Sturge Weber Syndrome is presented.


If the facial scar is a cosmetic problem 1 year after the injury, triamcinolone injections and local massage should be considered.


RESULTS: Acanthamoeba keratitis was diagnosed in six eyes with a previous misdiagnosis of Herpes simplex keratitis in two patients and a misdiagnosis of corneal graft rejection in the third patient.


The itch spread to the arms, abdomen and legs and the patient treated himself with clemastine and the itch disappeared.


These findings suggest that elevated intraocular pressure can contribute to interface inflammation.


A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.


DESIGN: Interventional case report.


He noticed nausea and headache and serum Na fell as low as 118 mEq/l.


Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.


A case of Kluver-Bucy syndrome associated with delayed cerebral necrosis after radiation therapy and chemotherapy is reported.


In our patient, histology showed aspects of drug-induced skin reaction without vasculitis.


A second challenge while the patient received all fluids and electrolytes intravenously again resulted in decreased serum sodium concentration (134 to 126 mEq/L) after urinary loss of only 69 mEq of cation.


We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.


Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use.


However, our patient was later found to have re-activation tuberculosis after long-term treatment.


Unusual pigmentary changes associated with 5-fluorouracil therapy.


Heat stroke-like episode in a child caused by zonisamide.


We believe this is the first report of intrathecal diamorphine causing anaphylaxis.


This case demonstrates the importance of blood flow from the peribiliary arteries for the survival of the biliary epithelium.


The diagnosis was confirmed by liver biopsy, antimitochondrial antibody, muscle biopsy, and electromyography.


PURPOSE: Differential diagnosis of maculopathies can be difficult but is important if patients also suffer from other diseases such as breast cancer treated with antiestrogens.


About 30% of patients have an initial remission on steroids alone, but most require some form of cytotoxic chemotherapy.


In the presence of left ventricular hypertrophy, the positive inotropic action of catecholamines with mainly beta-receptor specificity can lead to excessive hypercontractility and paradoxical hypotension.


This report describes a case of paradoxical, intravenous valproic acid-induced seizure exacerbation in a child with juvenile absence epilepsy, documented by video-electroencephalography.


Doctors involved in the use of indwelling intrathecal catheters for pain control must be aware of the risk of significant neurological sequelae but should not dismiss re-establishment of intrathecal therapy in the presence of significant neurological complications.


After cessation of treatment there was a gradual resolution with regain of normal nails after 7 months.


Myocardial infarction (MI), associated with the use of these concentrates, is a well-recognized, but uncommon, complication.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


One case presented with Stevens-Johnson syndrome, and the other had systemic papular erythema.


Clinical and chemical improvement was observed in the majority of subjects but normal 24-hour serum growth hormone levels were achieved in no more than 35 percent of this group and possibly less.


This translocation determines a fusion gene, bcr-abl, which encodes a constitutively active protein, tyrosine kinase, resulting in decreased apoptosis, defective adhesion, and genomic instability in transformed cells.


The patient had on the medial aspect of the thigh a fixed solitary, recurrent, indurated, erythematous plaque, which resolved within 2 days.


Hypoglycaemic brittle diabetes successfully managed by social worker intervention.


OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.


Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.


Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.


Coronary thrombolysis with streptokinase or tissue plasminogen activator is useful for the treatment of acute myocardial infarction in selected patients.


Inflammatory reactions in progressive multifocal leukoencephalopathy after highly active antiretroviral therapy.


We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.


A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy.


To our knowledge, the syndrome of fever, pulmonary infiltrates, and pleural effusion following use of acyclovir has not been previously reported.


Treatment with tacrolimus ointment completely resolved the oral lesions after 2 months of therapy.


Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.


Metoclopramide hydrochloride (Reglan) is a widely prescribed drug for treatment of upper gastrointestinal symptoms.


The first is a case of disseminated candidiasis with stomach wall involvement.


After having been on interferon therapy for three years, she developed skin lesions secondary to scleromyxedema.


Hydrofluoric acid burns.


The elimination half-life of both drugs is 0.5-0.7 hours.


Combination antimalarial therapy is being explored to delay development of resistance to falciparum malaria.


The acute reaction to nitrofurantoin is believed to be mediated by an immune mechanism.


She was found to have hyperventilation and weakness of four limbs, with muscle power of grade 5(-)/5.


Control hysterosalpingograms showed no tubal patency on the involved side.


BACKGROUND: reports on delated cutaneous reactions to captopril have been seldom reported.


A cutaneous biopsy for histologic analysis was performed.


She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.


Ibopamine-induced reversible leukopenia during treatment for congestive heart failure.


Perhaps for this reason, the teeth and craniofacial features of patients with leprechaunism have never been reported.


Among the various clinical and pathological manifestations of hydrocarbon (HC) poisoning, pneumonitis is the most significant and occurs in up to 40% of children, whereas formation of pneumatoceles is believed to be a rare event.


Later, he had no impulse disorders (no gambling, hypersexuality, excessive shopping), which occur with dopamine agonists, suggesting that levodopa abuse and impulse disorders can result through different mechanisms.


The patient was ultimately discharged to home.


Bone marrow biopsy showed a moderately hypocellular marrow; 51% of the nucleated cells were blasts with myelomonocytic differentiation.


Stroke is an infrequent but recognized complication of heroin addiction.


The temporal relationship suggests that the spinal cord infarction may be related to the use of zolmitriptan.


The patient had no skin reactions for the next 12 mo, with the exception of injection-site papules.


These findings suggest that bicytopenia in this patient was caused by D-Pen and may be due to different sensitivities in the hematopoietic lineage.


She was treated with an intra-articular injection of 80 mg methylprednisolone into her sacroiliac joint, followed 2 days later by a cluster of herpetiform vesicles adjacent to the injection site.


METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.


She had been receiving oral furosemide for 5 months at the time of this report, with no complications.


We report for the first time the development of symptomatic methemoglobinemia after an acute ingestion of divalproex sodium (Depakote), resulting in serum concentrations 10 times greater than the therapeutic range.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


Discontinuing the oxybutynin leads to complete neurological recovery associated with normalisation of her blood pressure.


Fever continued postoperatively until therapy with posaconazole was initiated.


RESULTS: There were several systemic complications including coagulopathy, hypocalcemia and pancreatitis.


Teriparatide is a promising treatment for patients who have failed bisphosphonate treatment or who are at high risk for fracture.


Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.


Over the next 4 months, there was progressive corneal stromal thinning and descemetocele formation in 1 eye, requiring application of cyanoacrylate glue, and stromal edema and scarring in the other eye, which resulted in a visual acuity of counting fingers.


After 36 h the hyponatremic episode improved after the infusion of hypertonic sodium chloride.


This report emphasizes the unnecessary hazard accompanying use of a potentially toxic drug-especially when prepared in error by the pharmacist-when a safer drug (nystatin) is available for treatment of oral candidiasis.


The drug has few side effects but some patients have developed clinical features of Cushing's syndrome.


In chronic hepatitis B viral infection TNF-alpha is readily produced, and viral clearance is dependent on the amount bioavailable.


His clinical features included erythematous, edematous plaques and peripheral neuropathy.


There are interesting effects of this drug in HIV-positive diabetic patients.


At a 1-year follow-up examination, the colonic stenosis was found have worsened; pneumaturia developed in January 2001.


A case report.


Secondary acute myelocytic leukemia after adjuvant therapy for early-stage breast carcinoma.


The patient was successfully treated with bilateral percutaneous nephrostomy drainage.


Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.


Acarbose attenuated both postprandial glucose hyperglycemia and reactive hypoglycemia, which subsequently led to a significant reduction in dumping symptoms.


By the findings of Grocott stain on bronchoalveolar lavage fluid obtained on day 14, he was diagnosed as having PCP.


A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.


The child was on no other medication and had been previously well.


However, infection with C albicans should be recognized as an extremely common complication to the wearing of dentures.


CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.


Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes.


The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.


Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?


The procedure offers patients the opportunity to avoid the risks and expense associated with surgical correction.


The wide use of phenytoin during the recent tuberculosis epidemic makes it imperative to suspect this drug interaction in patients exhibiting clinical features that might be related to phenytoin toxicity.


Systemic immunomodulatory agents have recently been approved for the treatment of rheumatoid arthritis and psoriasis.


Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


ABMT may later have triggered opportunistic infections in this patient.


We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.


Disseminated Fusarium is a rare but life-threatening infection of severely immunocompromised patients.


Caution is recommended when treatment is initiated in patients with hypertrophic cardiomyopathy in whom there is any suspicion of abnormalities in the atrioventricular conduction tissues.


RESULTS: Calciferous burning agents and corneal calcification are correlated (P<0.01).


However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.


CONCLUSIONS: PHD may play an important role in cases where macular thickness is successfully reduced or better acuity is achieved after intravitreal injections.


Serious underlying medical illness, recent antibiotic therapy, indwelling intravascular and/or Foley catheters, coincident candidiasis and low birth weight prematurity are major risk factors for candida shunt infection.


The first case, a 16-year-old African American male with an absolute CD4+ cell count of 314 cells/mm(3), presented with an abrupt rise in serum creatinine leading to irreversible renal failure while on TDF-containing highly active antiretroviral therapy (HAART).


Here, we report an 11-year-old girl with bilateral florid verrucous lesions on her hands, feet and chin, which were refractory to a number of standard treatments including cryotherapy, cantharidin preparations, topical salicylic acid, surgical debulking techniques, oral Cimetidine, and topical and intralesional Cidofovir.


The patients concurrent medications included didanosine, hydroxyzine, promethazine, hydrocortisone, and prochlorperazine.


The authors report a case of a patient who developed an intracranial hemorrhage following thrombolytic therapy that required emergency surgical intervention.


In Case 2, a combined regimen of oral antidiabetics and neuroleptica was later resumed.


Tumour necrosis factor-alpha inhibitors including infliximab are often used to treat a number of recalcitrant medical conditions.


It is important to recognize the potential for this complication when postoperative epidural analgesia is contemplated, especially following a left-sided surgical dissection.


Studies performed 10 years ago on 25 patients with MTX-induced liver cirrhosis indicated that this type of cirrhosis was not of an aggressive nature.


These effusions can be due to multiple causes with drugs being implicated as one of the etiological agents.


Barbiturate-induced submassive hepatic necrosis.


Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy.


We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.


Our treatment consisted of assisted ventilation with intubation, accompanied by calcium chloride infusion and forced diuresis with mannitol.


After the oily carcinostatic agents were administered by Lp-TAE, HT, at a temperature of greater than 42.5 degrees C, was induced for 40 min, twice a week by an RF of 8 MHz for a total of 10 to 38 times.


Antiandrogen treatment of aggressivity in men suffering from dementia.


However, as the use of hepatitis B vaccination is growing, adverse side effects, including mental nerve neuropathy, should be observed with an increased frequency.


A rare case of malignant osteopetrosis in a 19-year-old girl, who presented with the complication of osteomyelitis of the mandible following tooth extraction, is presented.


This event was caused by an erroneous switch with the 1% lidocaine/1:100,000 solution.


A patient presented with palmar inflammation and throbbing joint pain in his hands, as well as erythematous, pustular, and micaceous scaling skin on his right foot, legs, elbows and hands.


DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.


Immediately after application of 80 mg pyridoxine fits stopped and the EEG was without seizure activity.


We describe a case of coexisting psoriasis and SCLE initially treated with infliximab, and then alefacept.


Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus.


The drug may also accumulate irreversibly on the posterior surface of the cornea and on the anterior surface of the lens.


We report a case of severe AVP three weeks following the administration of infliximab for the treatment of Crohn's disease (CD).


Reflex epilepsy is the commonest form of epilepsy in which seizures are provoked by specific external stimulus.


Adverse drug reaction reporting by patients in the Netherlands: three years of experience.


The newer atypical antipsychotics are reputedly without adverse hematological effects.


L-asparaginase is a key component of the antileukemic therapy in children with acute lymphoblastic leukemia (ALL).


None of them had a history of cardiac disease, and with the possible exception of one case of cardiac arrest, where the patient received doxorubicin, no predisposing factors could be found.


In an infant with typical pyridoxine-dependent seizures, CSF GABA level, was determined before treatment with pyridoxine.


We describe the development of an invasive pulmonary aspergillosis in a patient using illicitly obtained marijuana as an antiemetic during combination antitumor therapy for small cell lung cancer.


Cystoscopy revealed erythema and exudate at the bladder walls, along with edema of both ureteral orifices.


CONCLUSIONS: Prolonged infusion of tissue plasminogen activator in escalating doses was safe and effective in the management of a large intracardiac catheter-tip thrombus and helped avoid open-heart surgery.


DATA SOURCES: Published articles, abstracts, and conference proceedings.


Isolation of Mycobacterium thermoresistibile following augmentation mammaplasty.


Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment.


CTPA identified no pulmonary embolus or vascular abnormalities.


Patient age, embolic source, and intensity of anticoagulation were not associated with hemorrhagic worsening.


Acute myelomonoblastic leukemia in a patient with multiple myeloma.


She was immediately given C1 esterase-inhibitor concentrate, made a complete recovery and was discharged next day.


Symptoms and signs of acute pancreatitis quickly returned.


Awareness of the various potential gastrointestinal toxic effects of bortezomib is of relevance given the growing number of patients undergoing treatment with this important and effective new cancer drug.


L-DOPA-induced excessive daytime sleepiness in PD: a placebo-controlled case with MSLT assessment.


Three days later a new recurrence of disseminated lichen planus occurred.


There is little likelihood of significant adverse effects attributable to topical minoxidil because of its low systemic absorption.


Dopaminergic drugs, particularly dopamine agonists, play an important role in triggering these nonmotor symptoms.


Six months postoperatively, she underwent a new scan that showed a normal supraspinatus tendon.


We herein report this rare case of acute onset of nephrotic syndrome during interferon-alpha retreatment.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.


Nevertheless, with appropriate safeguards described in this study, its topical use is safe.


However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.


She had no recurrence after 1 year.


Although the exact causes for bronchospasm in our case are not clear, CPB factors, such as the release of complements and allergic reactions might have induced the attack under relatively light anesthetic state.


The patient responded to lamivudine treatment with HBeAg seroconversion and significant regression of fibrosis.


We report on two patients with narrow angle glaucoma affected by chronic pain.


This case provides suggestive evidence that morphine-6-glucuronide can produce clinically significant effects in patients with mild renal insufficiency.


She was admitted to the hospital and later experienced monomorphic ventricular tachycardia, which resolved spontaneously.


Routine electrophysiological repetitive nerve stimulation studies recording amplitude of initial compound muscle action potential (CMAP) in thenar muscles correlate excellently with clinical myasthenic muscle power tests in clinically affected muscle groups.


Both asthma and thyroid disease are common disorders that occasionally occur together.


The severity of this syndrome primarily in patients undergoing second HPCTs suggests that repetitive exposure to high-dose therapy may compromise endogenous peripheral regulatory mechanisms and predispose these patients to autoimmunity.


At postmortem examination the cerebral hemispheres had a conspicuous destruction of white matter, consistent with a necrotizing leukoencephalopathy with focal and diffuse demyelination.


It is hoped that this case report creates awareness that ofloxacin-induced toxic epidermal necrolysis is possible.


Despite recent meta-analyses showing either similar rates or only slightly increased rates of stent thrombosis in patients with a drug-eluting stent, clinicians remain concerned about the risk of late stent thrombosis in these patients.


This initial coagulation response was followed by a second phase of hematological response (starting on days 15-20) characterized by leukocytosis, occurrence of myeloid progenitor cells in the peripheral blood, and a decrease in bone marrow blasts (<1% on days 28 and 36).


A case of a 53-year-old man who developed acute pneumonitis after bleomycin and moderate oxygen administration is presented.


A decision was made not to remove the implant but the hepatitis resolved completely and uneventfully well within the normal time-scale.


A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.


We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.


The crucial factors contributing to the deterioration of both patients in the two cases presented were the concentration of phenytoin manually infused and the possibility that their high-risk status made them poor candidates for manual intravenous phenytoin.


Paclitaxel and CBDCA therapy was indicated as second-line chemotherapy in one patient and as third line in four patients with recurrent disease.


For patients receiving hemodialysis (HD) who are exposed to gadolinium, the Federal Drug Administration (FDA) recommends HD to remove this contrast agent in order to minimize the risk of NSF.


Fatal outcome of intravesical formalin instillation, with changes mimicking renal tuberculosis.


The septal defect, repaired surgically by Hazeltine's method healed completely within 6 weeks.


There are now reports of liver failure following treatment of childhood cancers with AMD.


After standard treatment had failed, we tried to treat the patient by administering rituximab directly into the cerebral ventricle through an Omaya reservoir, in addition to conventional intrathecal and systemic chemotherapy.


IMPLICATIONS FOR NURSING PRACTICE: Nurses must understand the pharmacology, mechanism of action, clinical presentation, potentially lethal risks, and traumatic psychosocial stresses experienced by DPD-deficient patients with cancer receiving 5-FU therapy in order to develop timely interventions and alternative plans of care.


It can also be found in the United States, where illegal sales have been reported in California gift shops, markets, bakeries, and other retail establishments.


Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.


Three days after stopping the infusion she collapsed and died.


Adrenal crises in children treated with high-dose inhaled corticosteroids for asthma.


We suggested that colchicine should be used with caution in the presence of renal failure especially when other drugs which affect the metabolism of colchicine are also prescribed.


His serum calcium returned to a normal range in three months with Vitamin D and calcium supplement.


Objective improvement of tremor after use of metoprolol was documented by accelerometry.


Findings from biopsy specimens of skin and jejunum suggested a cell-mediated pathogenesis, and lymphoproliferative studies of the patient's mononuclear cells revealed a positive response to phenobarbital.


Uniquely, however, relief of peptic symptoms induced by hypergastrinemia is now available from acid-suppressive drugs such as proton-pump inhibitors (PPIs).


This rare association suggests that oral hormone replacement therapy poses a risk of thrombosis especially in patients with cc-TGA after prosthetic valve replacement.


Cyclosporine is a potent inhibitor of simvastatin metabolism, and may therefore facilitate simvastatin-induced rhabdomyolysis.


To the best of our knowledge, corneoscleral melting in the first postoperative week after a single intraoperative application of mitomycin C has not been reported.


This patient recovered after aggressive supportive therapy including intravenous alkali and fluid administration as well as continuous venovenous hemodiafiltration.


Streaky pigmentation in a patient with acquired immune deficiency syndrome (AIDS).


Liver biopsy was consistent with a drug-induced intrahepatic cholestatic reaction.


Urine volume ranged from 1,640 to 2,260 mL/24 hr, and serum creatinine level rose from 2.3 to 8.3 mg/dL.


We report a rare case of colonic mucosal necrosis following Kalimate (calcium polystryrene sulfonate), an analogue of Kayexalate without sorbitol in a 34-yr-old man.


Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.


A 69-year-old type 2 diabetic man was admitted due to diabetic gangrane.


Etoposide is an important component of current HLH treatment regimes.


The reporting rate for angioedema was calculated to be 9.8 cases per 1,000,000 pediatric patients.


The epiphyseal myeloid cells were reduced or sometimes eliminated during id injection.


Neurotoxicity can occur at any time using high-dose cytosine therapy.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


A patient presented with lactic acidosis and severe acidemia; sodium bicarbonate was administered to titrate the very large hydrogen ion load.


She developed large swellings in both sides of her lower abdomen.


In a series of 104 cases of intentional or inadvertent use of zidovudine at differing gestations in pregnancy, there were eight spontaneous first trimester abortions, eight therapeutic terminations, and eight cases of fetal abnormality occurring among a total of 88 cases where the pregnancy progressed.


Screening serologic tests for autoantibodies including antinuclear antibodies, antidouble-stranded DNA, anti-SS-A, anti-SS-B and anti-Sm were all negative.


Patients treated with captopril who develop "atypical cholangitis" should be suspected of having captopril-associated liver damage.


OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.


If associated with a prolonged QT interval, it is called torsades de pointes.


We discuss how these patients management differs from other intensive care unit patients with CLS and how it is important to diagnose this condition early in haematological oncology cases.


Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.


We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.


Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.


Endogenous pneumococcal endophthalmitis after splenectomy: report of two cases.


One patient was treated with amphotericin B and his central venous catheter was removed, but he died of Klebsiella pneumoniae bacteremia.


CONCLUSIONS: Any patient undergoing medical treatment for tuberculosis requires proper education concerning potential drug side effects.


It was presumed that the upbeating nystagmus in this case was elicited from the lesion of the anterior vermis of the cerebellum and/or its connections.


Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered.


Interstitial granulomatous dermatitis associated with darifenacin.


After using the antibiotic lock technique, the patient maintained his catheter without further infection for an additional 2 months.


Two animals were injected with balanced salt solution as controls.


The frequency of compensatory hyperhidrosis often reflects the extensiveness of the denervation.


In 3 dogs scheduled for surgical removal of cataracts, systemic and topical treatment with antibiotics and topical ocular treatment with prednisolone, atropine, flurbiprofen, and phenylephrine were used to achieve maximal mydriasis, with minimal risk of pupillary constriction in response to surgery.


We suggest adding this side effect to the list of untoward effects of lidocaine and to the differential diagnosis of fixed dilated pupils in neonates treated with lidocaine.


Tamoxifen has proved efficacious in all settings of breast cancer.


These findings strongly support the hypothesis that pulmonary capillaritis may represent a form of acute humoral rejection in the lung allograft that is less common than, and clinically and histologically distinct from, typical acute cellular rejection.


This adverse reaction is more common in children than adults and is rarely symptomatic.


A 77-year-old woman was urgently admitted for the treatment of diabetic ketoacidosis and a duodenal ulcer hemorrhage in March 1999.


CD3/CD4 T-helper lymphocyte count showed a significant decrease immediately after LT which rapidly recovered after initiation of HAART.


An individualized approach must consider local resources, the patient's age and prognosis, type of immunosuppression, opinions of patient and family regarding invasive measures and heroic support, and previous patterns of infection in the institution.


It appears to be selectively protective to salivary glands and kidneys without being tumor protective.


The favourable outcome in these two patients contrasts with the fatal outcome of the two other reported cases of nitrofurantoin induced BOOP.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.


Growth and spread of malignant cells within the stagnant dilated lymphatics are the likely cause of the characteristic nodular dissemination of the tumor in a lymphedematous extremity, regardless of the type of neoplasm.


Besides those manifestations, the patient also showed mucocutaneous lesions that were both clinically and histologically indistinguishable from those of pustular psoriasis.


Doxorubicin cardiotoxicity: possible role of digoxin in its prevention.


Complete seizure control was achieved but the patient developed hallucinations, agitation and self-harming behaviour, as well as poor social contact.


Twenty-nine patients reported spontaneous pain; a variety of other paresthesialike sensations, e.g., tingling, numbness, and formication, occurred in 32 patients.


An analysis of the literature shows that perfusion, usually combined with excision, seems to give definitely better results than surgical excision alone.


This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.


RESULTS: Ten eyes in 6 patients with late-onset interface inflammation and increased intraocular pressure were identified.


We believe that these skin eruptions belong to a spectrum of neutrophilic dermatoses that can be induced or aggravated by G-CSF therapy.


The nesiritide treatment duration was longer for this patient than the 45 days previously reported in a pediatric patient.


Thoracic CT showed a markedly enlarged mediastinum, with a voluminous mass in the middle mediastinum.


Prior neurologic illness and the syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).


Many pus cells and a few red blood cells were detected in the patient's stool, but the results of a stool culture for bacteria were negative.


Nitrogen-oxygen saturation therapy in serious cases of compressed-air decompression sickness.


These three cases illustrate the diagnostic and therapeutic overlap between childhood and adult anxiety disorders and indicate the need for empirical studies aimed at evaluating diagnostic and treatment issues in childhood anxiety disorders.


Immune-mediated reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are unusual, and true allergy to the drug flurbiprofen has never been documented.


G-CSF (50 micrograms/m2/day, subcutaneous injection) was administered simultaneously with a continuous intravenous infusion of Ara-C (70 mg/m2/day).


Pharmaceutical drugs, industrial compounds, and inhaled particles have been implicated as causative agents.


Using an illustrative case this article examines the prognostic significance of gastrointestinal haemorrhage and the risk of stopping anti-platelet therapy.


Although a few case reports link metronidazole with the development of pseudomembranous colitis, albendazole has not been associated with the development of this condition.


The infant had growth retardation and multiple anomalies including microbrachycephaly, coronal craniosynostosis, hypotelorism, shallow orbits, proptosis, blepharophimosis, small, abnormal ears, unilateral preauricular pit, broad, flat nasal bridge, microstomia, high-arched palate, micrognathia, preaxial upper limb and postaxial lower limb defects consisting of hypoplastic thumbs, and bilateral absence of the 4th and 5th toes.


An understanding of the proposed pathophysiology of various types of delirium will allow appropriate clinical measures to be taken.


Final treatment plans for the HNCP should include medical assessment of past dental history, oral hygiene, potential compliance, or lack of, to dental care recommendations, the emotional state of the patient, socio-economic status of the patient (lifestyle, cost of care), future quality of life, the medical and/or life prognosis of the patient.


After three cycles of chemotherapy over a 10-week period, the patient's dosage requirements returned to her baseline level (before treatment with 5-fluorouracil and leucovorin had started).


Severe abdominal pain in low dosage clofazimine.


Five of the patients had D-Dimers levels measured, all were elevated.


Bronchial anthracostenosis describes a disease entity consisting of bronchial destruction, deformity and stenosis related to dark pigmentation on bronchoscopy in patients with a history of coal workers' pneumoconiosis or chronic exposure to biomass smoke.


He recovered well and was able to walk by postoperative day 4.


Staphylococcus lugdunensis endocarditis following cardiac catheterisation.


Weight loss during therapy with olanzapine orally disintegrating tablets: two case reports.


In the untreated infant with Menkes Kinky Hair Syndrome, copper concentrations in brain and liver are deficient, while excessive copper accumulates in other tissues.


In a postural challenge test after administration of isosorbide dinitrate (5 mg), blood pressure decreased from 120/67 to 65/35 mmHg, followed by syncope with a sudden decrease in pulse rate from 85 to 60 beats/min.


This case, in which continuous morphologic adaptation of the cornea occurred, indicates that observation, rather than intervention, is a valid therapeutic option for stage 4 DLK.


Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.


Medical practitioners are also applying recombinant factor VIIa toward the control of bleeding in patients without hemophilia.


CASE SUMMARY: A 10-year-old white girl with bilateral optic glioma developed a hypersensitivity reaction to carboplatin after nine courses.


When patch test are performed with several drugs of the same family, results seem to indicate an absence of cross-sensitivity, but in several patients, oral provocation test were needed because patch test gave no conclusive information.


We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.


No changes in respiratory/hemodynamic status or oxygen saturation were observed.


Celiprolol pneumonitis.


Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.


Chest roentgenogram showed multiple pulmonary nodules.


Retroauricular incisions can be associated with complications, including cerebrospinal fluid leak and shunt infection.


Two had been treated with hydroxyurea for 16 and 21 months before imatinib therapy, while 1 was started on a regimen of imatinib following diagnosis.


Initial treatment with heparin was substituted with thrombolysis, which resulted in clinical improvement and dissolution of right heart thrombus but was followed by fatal intracerebral haemorrhage.


Acutely, SMS decreased acid secretion and restored the BAO/MAO to normal in eight of eight patients.


Pulmonary aspergillosis masquerading as progressive post-transplant lymphoma.


Tumor necrosis factor alpha (TNF-alpha) inhibitors, such as infliximab and etanercept, are now frequently used in the treatment of inflammatory diseases including rheumatoid arthritis (RA) and Crohn's disease.


But metformin has fibrinolytic features by means of diminished plasminogen activator inhibitor 1 activity.


Acceleration of ventricular response to atrial flutter after intravenous adenosine.


None of the patients demonstrated the requisite features of the 'Dilantin hypersensitivity syndrome'.


Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.


Inadvertent subsequent rechallenge with celiprolol led to recurrence of the pneumonitis, 10 weeks after drug readministration.


Severe diffuse interstitial pneumonitis induced by carmustine (BCNU).


Acute coronary syndromes complicating the first infusion of rituximab.


Since cranial MRI showed only nonspecific findings, CNS vasculitis associated with GVHD after BMT may be underdiagnosed.


We report a child with CF who developed significant hypomagnesaemia following intravenous (i.v.) treatment with aminoglycosides for exacerbations of Pseudomonas aeruginosa infection.


The patient had been on oral propranolol for the past five years and had taken his last dose of propranolol approximately ten hours before the administration of parenteral verapamil for treatment of a supraventricular tachycardia documented by an electrocardiogram.


We report a case of pelvic actinomycosis presenting as cutaneous fistula.


Following 3 months without any symptoms, the patient had total colectomy and ileostomy.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


L-asparaginase is a critical component in the treatment of acute lymphoblastic leukemia in children.


The clinical picture fulfilled the criteria of Kluver-Bucy syndrome.


Thrombocytopenia of Grade III or higher was observed in eight patients.


We present a case of postoperative nausea and vomiting resulting from a presumed lumbar CSF leak in a nonverbal child after surgical placement of a permanent intrathecal catheter.


Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.


Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.


The basic triad of symptoms that occurs in the TMA syndrome include microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment.


In the cornea, it has been shown in animal and in vitro studies to inhibit epithelium mitosis, fibroblast mitosis and migration, as well as to reduce collagen deposition.


EEG with polygraphic recording may detect clinically inapparent tonic seizures in epileptics with unexplained confusion, and when generalized paroxysmal fast activity occurs during EEG recording.


Detection of antineutrophil cytoplasmic antibody in a patient with L-tryptophan induced eosinophilia-myalgia syndrome.


IV propranolol was used as the initial treatment for his hyperadrenergic state, resulting in a decrease in heart rate but a paroxsymal increase in blood pressure.


A computerised tomography scan and a magnetic resonance imaging excluded a central lesion.


Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.


Care providers who refill pump reservoirs with morphine must be knowledgeable about these devices and the life-threatening consequences associated with errors in refilling them.


Severe vancomycin-induced anaphylactic reaction.


Pemphigus vulgaris precipitated by glibenclamide therapy.


In each of these cases, the treating psychiatrist faced the problems of noncompliance with treatment and/or restrictive civil commitment standards.


The thrombi were treated with successive intravenous fibrinolysis under transesophageal echocardiographic guidance, without complication.


Cannulation injury of the radial artery: diagnosis and treatment algorithm.


The mechanism of RTA induced by FK506 has not yet been clearly elucidated.


BACKGROUND: Bleeding is the most serious complication of oral anticoagulant therapy used for the prevention of thromboembolic complications.


Intravitreal bevacizumab (Avastin) as a treatment of the neovascular complications of laser-induced chorioretinal anastomosis for nonischaemic central retinal vein occlusion.


Although hepatic veno-occlusive disease (HVOD) is a common complication of allogenic bone marrow transplantation (BMT), pulmonary veno-occlusive disease (PVOD) is very rare.


Drug-induced pemphigus related to angiotensin-converting enzyme inhibitors.


We describe a child aged 11 years who ingested large amounts of plastic material used for knitting chairs and charpoys.


Gold-induced pneumonitis.


A patient with angioimmunoblastic lymphadenopathy with dysproteinemia was followed over a three year period from diagnosis to death.


Septic arthritis of the hip with Propionibacterium avidum bacteremia after intraarticular treatment for hip osteoarthritis.


The S typhimurium isolates from this patient, from other ill persons, and from raw milk were resistant to ampicillin, chloramphenicol, kanamycin sulfate, streptomycin, sulfonamide, and tetracycline.


In addition, a 31-year-old man with obsessive-compulsive disorder developed RBD soon after starting fluoxetine therapy, which persisted at PSG study 19 months after fluoxetine discontinuation.


In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.


A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation.


These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.


Four cases involving men with New York Heart Association functional class III heart failure are presented.


Tricuspid valve infectious endocarditis associated with dental treatment.


Apomorphine was effective in reducing the duration of diphasic dyskinesias at doses higher than the threshold doses necessary to induce an "on" phase (mean increase: 43%).


In our case, a 77-year-old woman, with stage IIIA IgG lambda multiple myeloma for two years, presented with firm nodular violaceous cutaneous lesions on the left arm without underlying bone osteolytic lesions or subcutaneous tumors; the biopsy was consistent with plasmacytoma.


Intensive care experience with intravenous cimetidine.


We report an allogeneic bone marrow transplant recipient who developed CMV infection refractory to sequential therapy with ganciclovir, foscarnet, and cidofovir.


Carbamazepine is an anticonvulsant most effective in treating complex partial and generalized tonic-clonic seizures.


We review and summarize all reported cases of patients with ART-associated lactic acidosis reported in the English literature.


We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.


A trial of steroid therapy following early detection of such obstruction in lieu of early surgical exploration is discussed.


Methadone, a synthetic opioid that is increasingly used for the management of chronic pain, has recently been implicated in the development of the prolonged QT syndrome.


Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.


Thus, ultrasound may prevent inadvertent placement of the needle into these structures as might happen with either the blind technique or fluoroscopic technique.


Capsule endoscopy showed bleeding diffuse angiodysplasia of the small bowel.


Phenytoin levels were reduced to 37% of the original values, although the drug was given intravenously.


CONCLUSION: Intravitreal rituximab at a dose of 1 mg does not appear to cause toxicity in rabbit eyes and in the five eyes of three patients.


RESULTS: Seven patients showed marked visual field constriction with some sparing of the temporal visual field.


Some of these lesions coalesced into plaques, with small areas of sparing, and a background erythematous color was also found in the axillary vaults (Fig.


Flucloxacillin-induced aplastic anaemia and liver failure.


Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy.


Over the next few days he showed rapid clinical improvement with normalization of his blood chemistries and he was discharged home after 5 days of hospitalization in good condition.


Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.


Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.


Eosinophilia has been encountered from 0.2 to 61.7% in clozapine-treated patients, mostly with a transient course and spontaneous remission.


CONCLUSION: Although uncontrolled case observations can only be interpreted with caution quetiapine seems to deserve further investigation and may hold the potential for preventing alcohol relapse in alcoholics suffering from additional above-mentioned symptoms.


Laboratory evaluation showed high levels of thyroid-stimulating hormone (TSH).


We describe a patient in whom impressive hypoglycemia developed following treatment with this agent.


The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.


Four years after transplantation the patient was admitted again due to sudden worsening of New York Heart Association functional class and extreme fatigue.


Relationship of eye burns with calcifications of the cornea?


We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.


However, he experienced a subsequent recurrence of the eruption on inadvertent rechallenge.


However, each infant demonstrated hemodynamic decompensation shortly after verapamil administration and required cardiopulmonary resuscitation.


CONCLUSIONS: The pathogenesis of methotrexate-induced papular eruption in collagen vascular diseases may suggest cutaneous small-vessel vasculitis.


Samples with concentrations exceeding the linearity were diluted.


An urgent EEG is essential to confirm the diagnosis.


OBJECTIVE: The goal of this article was to describe a potential drug-drug interaction between propafenone and citalopram, which caused symptoms of propafenone adverse effects.


CONCLUSIONS: We describe a previously unreported complication of warfarin therapy in a patient over 75 years of age, to add to the cautions in prescribing this drug in patients of this age group.


The development of rickets as a complication of chemotherapy for the treatment of Wilms' tumor.


An additional disorder in the spectrum of thyroid related muscle disease is presented.


This treatment is associated with local hemorrhagic complications and age-related cerebral hemorrhage.


CONCLUSION: Squamous metaplasia in these cases appears to be a consequence of progestin therapy.


Primary coronary artery dissection occurring 2 months post partum in a 33-year-old woman is described.


Valproate remains the medication of choice for the treatment of petit mal status.


Multiple acquired haemostatic defects.


Most alternative remedies have not been adequately studied or proven effective for the diseases for which they are promoted.


The relation between tacrolimus treatment and staining was suggested by the appearance of pigmentation during topical tacrolimus treatment and its clinical disappearance when treatment was stopped.


The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.


At the time of transplantation the patient was severely neutropenic.


Treatment of coccidioidomycosis with amphotericin B may be accomplished via an Ommaya reservoir.


We presented the case of a patient who developed a cutaneous reaction induced by captopril with positive patch test.


Pegylated interferon alfa-2b is a formulation of recombinant human interferon conjugated with polyethylene glycol.


Exacerbation of the inflammatory response to Mycobacterium tuberculosis after antiretroviral therapy.


Development of porphyria cutanea tarda after treatment with cyclophosphamide.


In two patients the infection spread per continuum, in the other two patients due to haematogenous dissemination.


Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.


Clinically, our patient showed a vasculitic-like skin rash involving both palms and soles, and histopathological examination revealed a syringotropic lymphocytic infiltrate directed toward the intra-epidermal portion of the eccrine ducts.


Immunosuppressive measles encephalitis.


A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.


Of the eight patients in clinical trials, five had cardiovascular abnormalities and two had acquired immunodeficiency syndrome-related pneumonia.


Histologically, we diagnosed this case as having pre-cirrhotic nonalcoholic steatohepatitis (NASH).


The study included three men and one woman aged 52-65 years.


The greater activity of steroid-treated individuals may place their dystrophin-deficient muscles under greater mechanical stress, predisposing to further muscle fibre damage and consequent myoglobinuria.


It usually increases the severity of reactive arthritis.


Expect clonidine intoxications to become more common as the market for antihypertensive drugs expands.


In these two patients, five of six treated tumors decreased in size, and three completely responded.


Cough induced by quinapril with resolution after changing to fosinopril.


Ishihara color plates showed a marked, acquired color vision defect O.D., O.S.


Two of them had acute myeloid leukemia and four had lymphoblastic leukemia.


Increased awareness of DIC as a diagnostic possibility may enable prompt recognition and medical intervention in affected patients.


We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).


Eosinophilia caused by clozapine was observed in challenge, preceded by a faster neutrophil production and consecutive decrease (z = 2.27, p = 0.01).


Successful treatment of post-transplant lymphoproliferative disorder in autologous blood stem cell transplant recipients.


Early data identifies atomoxetine's influence on Tourette symptomatology to be not merely equivocal but potentially suppressive in the manifestation of tics.


A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


DISCUSSION: Amphotericin B deoxycholate has been reported to produce significant cardiac toxicity, with ventricular arrhythmias and bradycardia reported in overdoses in children and in adults with preexisting cardiac disease, even when administered in conventional dosages and infusion rates.


Pseudoporphyria induced by propionic acid derivatives.


The patient developed grade 3 capecitabine-induced headache.


Grand mal seizures and acute intermittent porphyria.


CASE REPORT: A 77-year-old female nursing home resident was inadvertently administered 50,000 units of oral vitamin D daily for 6 days.


Cholestyramine induced hyperchloremic metabolic acidosis.


All the episodes occurred after the first dose was administered, and the seven patients recovered without sequelae after the drug was withdrawn.


Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.


Between 1989 and 1996, 4 cases of Pneumocystis carinii pneumonia (PCP) were observed in patients seronegative for the human immunodeficiency virus who were receiving corticosteroid therapy for dermatomyositis in our institution.


During orthotopic liver transplantation a patient received epsilon-aminocaproic acid and clotting factors.


Lipoatrophy is a thing of the past, or is it?


Severe ehrlichia infection in pediatric oncology and stem cell transplant patients.


Contact with hydrofluoric acid may produce extensive tissue necrosis.


This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.


Despite the prophylaxis and preemptive strategies using potent antiviral agents, cytomegalovirus (CMV) remains a major infectious cause of morbidity and mortality in allogeneic stem cell transplantation (SCT) recipients.


The diagnosis of this entity is difficult, if not misdiagnosed, because of its rarity and its subacute presentation.


The ECG monitoring revealed sinus pause with markedly prolonged PQ interval and QRS width.


Diuresis returned within 12 h.


We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).


5-Fluorouracil cardiotoxicity complicating treatment of stage IIB cervical cancer--case report.


A case of brain abscess developing 2 weeks after insertion of skull tongs is reported.


The patient, with a history of cardiovascular disease and glaucoma, was admitted to the hospital because of complaints of shortness of breath, orthopnea, and reduced exercise tolerance.


This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.


Her symptoms and elevation of pancreatic enzymes did not respond to conventional medical treatment of pancreatitis for 18 d.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Kaposi's sarcoma in the setting of immunosuppression and the gastrointestinal manifestations of this disease are reviewed.


The patient had a very aggressive type of posttransplantation HCV infection, as judged by biochemical and histologic findings.


Most patients with ergot toxicity present with symptoms of lower extremity claudication.


Thyrotoxic Periodic Paralysis is an uncommon disorder seen primarily in Asian males and caused by excessive thyroid hormones.


Temozolomide is an oral alkylating agent used in the treatment of metastatic melanoma.


We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.


The observations suggest that testicular swelling and pain are side effects of desipramine.


Her left ovarian cyst was extirpated surgically, and the histological diagnosis was endometrial cyst.


CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.


Patch tests with flurbiprofen were positive 48 and 72 h after application.


NEH must be considered in lupus patients receiving cytotoxic agents to avoid inappropriate use of corticosteroids or antibiotics in this self-limited condition.


Transient asymptomatic bradycardia in patients on infusional 5-fluorouracil.


QT interval was more than 500 m sec.


Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.


Rigorous diagnostic procedures with repeated scintiscans and TSHRAb titering are necessary to avoid a false diagnosis and inappropriate therapy.


The management of leukaemia presenting in pregnancy is discussed.


The possible role of the autonomic nervous system in the causation of acute coronary vasospasm is discussed, and this is highlighted as an unusual cause of myocardial ischemia during thoracic spine surgery.


Diffuse pulmonary uptake of labeled leukocytes was observed in all three individuals.


Although activated clotting time (ACT) monitoring is encouraged to verify the adequacy of anticoagulation during the procedures, this is not a common practice in many laboratories.


Therapy with phenytoin, phenobarbital, valproic acid, and methylphenidate was unsuccessful.


Doses were gradually reduced in the following days and finally discontinued on day 28 after surgery.


Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer.


Measurement of serum digoxin concentrations (SDCs) is used routinely in the diagnosis of digoxin toxicity.


This is despite relatively poor clearance of the drug through peritoneal dialysis.


Successful management of supraventricular tachycardia has been maintained in the 10 remaining patients for 15 to 36 months (average 26.4).


METHODS: Review of clinical chart and photographs.


Pulmonary fibrosis is a severe complication associated with bis-chloronitrosourea (BCNU) therapy.


A patient with hematologic malignancy and hepatitis B virus (HBV) infection received chemotherapy containing a glucocorticoid.


He was initiated on oral as well as inhaled corticosteroids along with nasal corticosteroid spray for his nasal complaints.


Myoclonic spasms following intrathecal morphine.


Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.


Moreover, this case illustrates the usefulness of laser capture microdissection to obtain purified cell populations for molecular studies in lymphomas with relative paucity of tumor cells, as well as the need to analyze different IgH gene regions to decrease the rate of false-negative results in PCR clonality studies.


Intravenous azithromycin is increasingly administered for treatment of hospitalized patients with community-acquired pneumonia.


We suspect that nefazodone inhibits metabolism of tacrolimus.


Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.


In three cases acetohexamide (Dymelor), an oral hypoglycemic agent, was mistakenly given to patients instead of acetazolamide (Diamox), which had been prescribed for their glaucoma.


Although a few cases of "sarcomas" of the endometrium that had developed in an estrogenic setting have been reported, a clear-cut association between estrogenic stimulation and these forms of endometrial cancer has not been established.


No further problems were encountered over the follow-up period of nine months.


Itraconazole is particularly attractive in fungal prophylaxis for cancer patients due to its broad spectrum, including Candida and Aspergillus.


The spectrum of nitrofurantoin lung injury continues to widen.


Published 2001 Wiley-Liss, Inc.


3,4-Diaminopyridine (3,4-DAP) given alone or combined with pyridostigmine is the recommended basic therapy in the Lambert-Eaton myasthenic syndrome (LEMS).


Since the patient was immunosuppressed with etanercept and since the uveitis was granulomatous we considered tuberculosis as a possible etiology.


Suspected ciprofloxacin-induced interstitial nephritis.


For treatment of a posttraumatic intramural jejunal haematoma with extension into the mesenterium the patient received continuous infusion (CI) of a high purity F VIII concentrate, starting with an initial bolus injection of 100 IU F VIII/kg bw and followed by 4-5 IU F VIII/kg bw/h i.v.


Blood and bone marrow morphology, and the karyotype were normalised and the patient is in good health 1 yr post-transplant.


Transfusion-related acute lung injury.


It has been described most recently in patients with solid tumors who receive taxane-based therapy.


CONCLUSIONS: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon alpha administration.


The intraocular pressure normalized several months following discontinuation of treatment.


We used Hybrizep (a method for detecting the genes of bacteria ingested in phagocytes), to detect the causative bacterium in a 50-year-old woman receiving peritoneal dialysis who was admitted our hospital with bacterial peritonitis.


The use of systemic corticosteroids in this condition is not established.


Of the five that were treated with toxin, four showed complete resolution of symptoms after a course of treatment.


We address the clinical problems and possible detrimental effects of CSFE in the setting of shunt infection.


Thoracoscopic wedge resection of left upper lung performed 10 days before patient's death showed severe pulmonary fibrosis with prominent hyperplasia of alveolar macrophages and type II pneumocytes.


Agrobacterium yellow group: bacteremia and possible septic arthritis following peripheral blood stem cell transplantation.


RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.


Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.


Although rare, massive pulmonary embolus must be considered to be a major risk of thrombolytic therapy for deep venous thrombosis.


Interference with the cortisol axis by the microtubule antagonist, CPH82.


CONCLUSIONS: Blood data did not always reflect marrow status.


Resolution of recalcitrant warts with IV Cidofovir has been reported in a limited number of cases.


Calcium administration should also be considered.


The patient did not fulfil criteria for Churg-Strauss syndrome.


We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.


SUMMARY AND BACKGROUND DATA: The subjects of this study were patients with intractable pain in donor area after conventional treatments using a transverse incision, which is parallel to posterior iliac crest.


Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.


Most cases are treated relatively easily, but recurrences are frequent and the infection often spreads to other parts of the oral mucosa.


Finally we noticed that our confusion had resulted from test tubes containing lithium heparine.


He developed abnormal neurological findings during follicular lymphoma treatment, brain CT revealed ring-enhancing, multiloculated lesions, and N. exalbida was detected by aspiration of the lesion.


Comorbidity of parkinsonism and schizophrenia in a patient treated with clozapine.


However, in approximately 80% of the population, the inferior cervical ganglion is fused with the first thoracic ganglion, forming the stellate ganglion also known as cervicothoracic ganglion.


Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.


She was then treated by surgical excision of the infected tissues and by antibiotics: Amoxicillin, Metronidazole and Gentamycin for one month.


Nitrous oxide produces irreversible oxidation to the Co++ and Co forms that renders vitamin B12 inactive.


Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.


We speculate that in addition to the administration of M-CSF, hypercytokinemia during the early phase post-alloBMT might have contributed to the onset of HPS in this patient.


We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT).


Electrophysiological study revealed atrioventricular nodal reentrant tachycardia in the first case, and atrioventricular reentrant tachycardia due to a concealed left lateral accessory pathway in the second case.


A noninvasive method in the differential diagnosis of vecuronium-induced and magnesium-induced protracted neuromuscular block in a severely preeclamptic patient.


Nine of the 11 patients with congenital hydrocephalus are currently well without any further medical or surgical intervention.


Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.


We present a patient with systemic lupus erythematosus who presented with nephrotic range pseudoproteinuria using an acid precipitation method of testing.


There are several factors which might promote a peripheral ischemic response to vasopressin in the bleeding cirrhotic patient, including altered resting hemodynamics, increased resting sympathetic tone, impaired vasodilation as a compensatory response to vasopressin, and reduced hepatic drug clearance.


Pravastatin is associated with myotonia in animals.


When isolated from the blood and/or the CSF of a patient with a CSF shunt who has symptoms and signs compatible with infection, the organism should not be dismissed as a contaminant.


Computed tomography revealed thickening of the terminal ileum wall and paralytic ileus.


This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.


A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.


Haptoglobin was undetectable.


Diclofenac was immediately stopped, leading to a complete restoration of liver functions over the course of the next few months.


We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy.


The combination of selective serotonin reuptake inhibitors and tricyclic antidepressants may be useful in treating patients who experience intolerable side effects or who are resistant to therapy with a single antidepressant.


The peritonitis in these patients differed from the typical picture in which a single aerobic organism is responsible, by the presence of multiple organisms, some of which were anaerobic.


We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.


BACKGROUND: Second-line treatment options are limited in controlling advanced thoracic cancer in patients who have progressed following first-line chemotherapy.


We report a case of a recurrent Listeria monocytogenes bacteraemia in a 46 year-old liver transplant patient.


Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.


We evaluated the response to gluten restriction and normal diet by following the status of the patient's jejunal biopsies and skin lesions.


PARTICIPANTS: Four patients with periocular hemangioma.


CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.


A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.


A 73-year-old woman presented with fever and cough 2 weeks after completing the third cycle of fludarabine for chronic lymphocytic leukemia (CLL).


Although this condition occurs primarily in severely myelosuppressed and immunosuppressed patients with leukemia, it may also occur in those with other advanced malignancies receiving myelosuppressive chemotherapy.


When the thyrotoxicosis recurred, accompanied by a severe psychotic reaction, administration of antithyroid medication was recommenced.


Typically, flupirtine exerts membrane stabilizing and hyperpolarizing effects through activation of neuronal G-protein regulated inwardly rectifying potassium channels (GIRK).