We report a new case of mitral valve endocarditis after stent implantation to a saphenous vein graft.


Its potential usefulness in reversing adverse effects encountered during therapeutic dosing with beta-blockers has not been well characterized.


DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.


The patient was admitted to the hospital and treated for SIADH.


Severe hypopharyngeal dysphagia in a patient on chronic steroid treatment.


CASE SUMMARY: A 30-year-old man with bipolar disorder and HIV initiated treatment with lopinavir/ritonavir, zidovudine, and lamivudine.


We suggest that the cause of this distressing syndrome, and ways to mitigate or circumvent it, must be discovered.


Grade IV leucopenia and thrombocytopenia were observed in one of three patients at the 100 mg/m2 dose level.


In this paper we present a patient with the diagnosis of nephrotic syndrome and a known history of hepatitis C who received IFNalpha therapy for newly diagnosed CML.


We report here two cases of dyserythropoietic anaemia associated with long-term linezolid use that share striking similarities to chloramphenicol-associated myelotoxicity.


Early deaths with thrombolytic therapy for acute myocardial infarction in corticosteroid-dependent rheumatoid arthritis.


Changing treatment from efavirenz to a protease inhibitor was accompanied by improvements in the desired urinary Histoplasma antigen level and plasma itraconazole concentration.


Appropriate stains indicated that this had many characteristics of lipofuscin.


Oseltamivir was well tolerated outside vomiting during the first three days of treatment in one patient.


The histopathology of the subretinal fibrotic tissue confirmed the diagnosis.


It would be advisable to measure thiopurine methyltransferase activity before patients with autoimmune hepatitis are exposed to azathioprine.


Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol.


Outcome is probably more dependent on the clinical condition of the patient and the reversibility of the drug toxicity.


RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment.


The tumor necrosis factor-alpha antagonist (TNF-alpha) etanercept has been approved for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and psoriasis.


The infiltrate disappeared within 6 weeks.


Hospital drug therapy included enoxaparin.


This report demonstrates the increased risk of complicated varicella associated with the use of corticosteroids, even for a short period of time.


One of these patients showed pyramidal features and subsequently developed an optic neuropathy and pigmentary retinopathy.


Before recognition of pregnancy, the latter had been treated for acute myelocytic leukaemia receiving cytarabine, daunorubicin and doxorubicin at conception and cytarabine and thioguanine at about 35-37 days post conception.


A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days.


Polymyositis masquerading as mitochondrial toxicity.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.


This case demonstrates that there is no cross reactivity between glyburide and chlorpropamide in producing hemolytic anemia.


The pathogenic mechanisms involved in the development of adriamycin cardiomyopathy are reviewed, and the possible synergistic effect of other antitumor antibiotics is discussed.


Punctate keratitis with keratinization of the cornea led to complete loss of vision.


She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.


A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.


Increasing clinical experience with the selective serotonin reuptake inhibitors and tricyclic antidepressants make combination antidepressant therapy at times a reasonable alternative to single-agent therapy in primary care patients with depression.


Ehrlichiosis, a tickborne illness transmitted by tick vectors Amblyomma americanum and Ixodes scapularis, can be acquired in endemic areas.


A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.


Transient acute myopia resulting from isotretinoin (accutane) therapy.


Interstitial pneumonitis, induced by hormone treatment given for prostate cancer, is a reversible condition and a quick diagnosis followed by prompt, proper treatment is important to ensure a successful recovery.


It usually occurs in otherwise healthy young adults, often in association with a severe soft tissue infection and has a 30% mortality rate.


We describe a case of 73-year-old patient who has been operated in emergency on triple coronary artery bypass graft (CABG), which was complicated with respiratory insufficiency and devastating mediastinitis.


Interaction between antiepileptic and antiretroviral agents is an emergent problem caused by the increasing association of the two therapies.


Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathologic syndrome with characteristic features.


An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine.


We report a case consequent to a surgical operation for cataract.


Application of the Naranjo probability scale categorized this adverse reaction as being probably due to LMWH.


It responds well to conventional treatment along with the discontinuance of rifabutin.


Migraine prevention.


Patch testing for ethylenediamine was positive.


Cases illustrating the following concepts are presented.


We discuss 2 recent cases seen at our institution and 39 cases described in the English-language literature since 1995.


BACKGROUND: Fluticasone propionate was introduced in 1993 in the UK as a potentially safer inhaled corticosteroid than those already in use.


In fact, this error has taken place a number of times in North America in the preceding decade.


The diagnosis of disseminated Zygomycosis was made four days after onset of clinical symptoms.


Protamine sulphate 50 mg was given i.v., resulting in cessation of bleeding and normalization of the thrombelastogram and KCT.


Throughout hospitalization the patient underwent aggressive diuresis.


Avascular necrosis of bone: the hidden risk of glucocorticoids used as antiemetics in cancer chemotherapy.


The intramuscular challenge test with 25 UI of Miacalcic was positive with an immediate anaphylactic reaction.


A selective association between fluoxetine and extensive, prominent eye movements in nonrapid eye movement (NREM) sleep was detected, utilizing Fisher's exact one-tailed statistic (p less than 0.00001 for each comparison).


HNCPs with malignant disease require judicious dental treatment planning prior to radiation therapy (RT) and/or chemotherapy.


These lesions were attributed to treatment and recurred soon after a rechallenge with omeprazole.


METHODS: A retrospective review of 136 central line (Broviacs [B], Port-A- Caths [PC] and Hickmans [HC]) removals during the last 5 years was undertaken.


Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.


OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.


OBJECTIVE: To demonstrate the potential value of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and instituting prophylactic therapy in culture-positive cases, even in the absence of clinical evidence of established microbial keratitis or endophthalmitis.


The liver also showed peliosis hepatis.


After 20 months of therapy on etanercept, his plaque psoriasis markedly improved, whereas both his fasting blood sugars and glycosylated hemoglobin A(1c) decreased.


Seven of the twelve were treated with beta blockers; 3 of whom suffered cardiac arrest.


All received tissue plasminogen activator.


The scleritis completely resolved after initiation of systemic corticosteroids.


All patients received base-line immunosuppressive therapy with one or more of the following drugs: cyclosporine, corticosteroids and azathioprine.


The induction of hypoglycaemia with PAS in this patient suggests a potential role for PAS in the treatment of diabetes mellitus.


Despite continued improvements in mortality associated with a spinal-cord injury, until recently little progress had been made in improving neurologic function.


Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.


Sensory neuropathy revealing necrotizing vasculitis during infliximab therapy for rheumatoid arthritis.


CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.


During her third cycle, she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus, urticaria, and edema.


Symptoms of major depression: acute effect of withdrawing antidepressants.


Ampicillin-induced interstitial nephritis with generalised exfoliative dermatitis.


Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.


Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.


We present the course of illness of a 56 year-old patient with acute gastrointestinal bleeding after penetration of an aneurysm of the hepatic artery in the duodenal bulb.


We describe the clinical course of an EBV seronegative 11-yr-old boy who underwent double lung transplantation and subsequently developed PTLD in the graft.


Dissolution of pancreatic stones by oral trimethadione in patients with chronic calcific pancreatitis.


Enalapril-induced anemia in two kidney transplant recipients.


All 24 of them received mecamylamine in 2.5-6.25 mgm/day dose, at varying starting dates during the years June 1997 to June 1999.


Cutaneous bacterial infections, most commonly caused by Pseudomonas aeruginosa, have been clearly linked to use of hot tubs.


A 37-year-old male ingested 12 gm of fluoxetine approximately 2 hours prior to arrival at an emergency department.


Posterior tibial tendon rupture in a world class runner.


Early diagnosis of WE is important, because if it is treated with thiamine in the acute stages, the neurologic and cardiovascular abnormalities can be reversed.


The catheter was removed after 14 days because a local infection developed that resolved uneventfully with antibiotic therapy.


Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.


Chemotherapy was held.


Diagnosis may be confirmed by CT-scanning of the orbits.


However, the implication of TMP/SMX inducing aseptic meningitis has been underreported to FDA/MEDWATCH program.


The patient had a history of four resections since the age of 19 years.


The institution of lithium treatment in 1964 caused a dramatic improvement in the patient's condition.


Thirteen parkinsonian patients drawn from two large parkinsonism clinics experienced hypersexuality as a consequence of anti-parkinsonian therapy.


However, glucose-phosphate dehydrogenase was normal in the present case, suggesting that it is not a predisposing condition to the lung injury.


Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.


CASE REPORTS: Serial clinical examination of three patients was performed.


Chryseobacterium indologenes is a non-fermentative Gram-negative bacillus that is a rare pathogen in humans.


Encephalopathy and death may occur.


In this report, two patients with advanced rheumatoid arthritis, who were safely and effectively treated with dapsone after failure with other second-line agents, are described and the literature is reviewed.


People who become dependent on these mixtures commonly do not present for medical assistance until the problem is severe.


We report a case of myoclonus induced by quetiapine.


Long-term clinical and pharmacokinetic studies will be required to determine whether or not niflumic acid can be employed in the prevention or treatment of both of apparently idiopathic osteoporosis or corticosteroid-induced osteoporosis.


Acute renal failure should be recognized as a potential complication of suramin treatment.


Epoprostenol is a vasodilator that is produced by vascular endothelial cells and is currently the "gold standard" therapy for patients with severe primary pulmonary hypertension or pulmonary hypertension secondary to collagen vascular disease.


Magnetic resonance imaging (MRI) showed superior sagittal sinus (SSS) thrombosis and meningeal enhancement.


This study covers 3 years of experience with patient reporting in daily practice.


METHODS: A 54 year-old male was treated with alendronate sodium 70 mg orally once per week.


Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.


She was treated with intravenous fluids and discharged.


DNA-based analysis of amniotic fluid (AF) from at-risk pregnancies has been suggested as an adjunct/substitute for traditional culture.


Pharmacogenetics of antidepressants: clinical aspects.


Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy.


Lipoatrophy although rare can still occur even with the use of technologically advanced insulin preparations.


Complications occurred after transplantation and a rejection crisis worsened the clinical picture until the patient died about 4 months later.


Subsequent relaxation training inhibited vomiting after two sessions.


Used injudiciously, naloxone can lead to withdrawal syndrome, return of severe pain, and other adverse effects.


INTRODUCTION: Chronic constipation is a common symptom in pediatrics, and physicians often use mineral oil to treat chronic constipation in children.


We suggest the use of trihexyphenidyl in combination with isoprinosine in patients with subacute sclerosing panencephalitis with myoclonic seizures refractory to valproic acid.


Two of the patients were infected with human immunodeficiency virus.


RESULT: This clinical entity is usually encountered between the third and fifth decades.


Hepatic Sinusoidal Obstruction Syndrome (HSOS), the new name given to veno-occlusive disease (VOD) of the liver, is a well-known complication of high-dose chemotherapy employed with hematopoietic stem cell transplantation, but it has rarely been observed in children who receive conventional chemotherapy.


Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.


Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.


All 4 patients survived and left the hospital on postoperative days 10, 11, 11, and 82, respectively.


A 47-year-old woman began treatment with cloxacillin due to acute cellulitis.


A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.


Blurred vision, left bundle-branch block and cardiac failure.


The patient presented with focal seizures which led to epilepsia partialis continua and then progressive obtundation.


In conclusion, although APOLT showed clinical and laboratory improvement for some period in this patient, the final fatal outcome suggests that liver transplantation should be cautiously applied to patients with HUS associated with FH deficiency.


Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t-MDS revealed a clonal abnormality; 46,XX,add(7)(p13), der(17)t(3;17)(p11;p13).


The present report describes the first case of acute pancreatitis associated with danazol treatment of endometriosis.


The purpose of this study was to examine the incidence and cause of Clostridium difficile colitis occurring after cisplatin-based combination chemotherapy in ovarian cancer patients.


CONCLUSION: There are only a few confirmed cases of gemcitabine-associated HUS despite the widespread use of the drug.


If aggressive surgical therapy is not an option, the prevention of secondary complications such as infection becomes the goal of treatment until the necrotic process stops and healing begins.


Here, we report the successful treatment of a colonic ulcer that had penetrated the urinary bladder.


Our case indicates that clearance of PVB19 by IVIG in transplant recipients might be delayed after recovery of anemia.


Reversal of pathologic cardiac parameters after transition from clozapine to olanzapine treatment: a case report.


If antiarrhythmics are administered that are contraindicated in patients with WPW syndrome, then there is potential for deleterious effects.


We document the rare occurrence of primary biliary cirrhosis (PBC) and polymyositis in a 68-year-old woman.


Although many cases are reported to recover with colony-stimulating factors and corticosteroids, others are unresponsive or partially responsive.


Gastrointestinal ulcers occur frequently and are mainly caused by H. pylori infection.


Chronic use of ergot alkaloids has been recognized as a rare cause of lower extremity ischemia.


Two children were judged to be treatment failures.


This study shows that PID patients are susceptible to BCG dissemination and demonstrates the importance of an early diagnosis for their prognosis.


To the best of our knowledge, this is the first case of lithium-associated CDI and NDI presenting concurrently.


Phenytoin desensitization monitored by antigen specific T cell response using carboxyfluorescein succinimidyl ester dilution assay.


RESULTS: The patient presented with recent-onset delusional ideation associated with cognitive decline.


Our patient is doing well and is continuing life-long anticoagulant therapy.


A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.


Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.


Thalidomide was withdrawn from world markets in 1961 following recognition of its teratogenic effects.


METHODS: An in vitro model was used to determine the extraction ratio of ifosfamide by dialysis.


The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.


This case illustrates the clinical benefit of thrombolytic therapy in the setting of acute stroke associated with cardiac catheterization.


Perhaps more importantly, this study suggests that DPOAEs may have the potential to predict the earliest stages of progressive hearing loss before such changes are seen in audiometric thresholds.


At completion, examination revealed mild induration of the neck with near-complete resolution of the mass.


Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


Despite administration of phenytoin and lorazepam, the seizures persisted and occurred only during amphotercin B administration.


BACKGROUND: Mycophenolate mofetil (MMF) is a potent, safe immunosuppressive agent for rescue therapy of acute and chronic rejection in orthotopic liver transplant recipients.


Only after 3 months of treatment with two investigational topical products, which are now available to the public, was the dermatitis resolved and complete healing achieved.


This is the first histologically confirmed case of NASH that was aggravated by raloxifene.


Hemolytic uremic syndrome appeared, while no evidence of residual tumor was found.


Bowel perforation associated with intraperitoneal chromic phosphate instillation.


It is concluded that SIADH is an important side effect of lorcainide therapy.


An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug.


Unique to these three cases was profound granulocytopenia and the culturing of Pseudomonas aeruginosa in both the blood and necrotic perineal-scrotal tissue.


A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.


Acyclovir, an antiviral nucleoside analogue, is a widely used agent highly specific for herpes simplex and varicella-zoster viruses.


The endometrium showed patterns of glandular cystic hyperplasia.


The cases demonstrate that ECT has significant but short-lived antipsychotic effects when used alone.


Varicella-zoster virus vaccine has diminished the consequences of chicken pox in terms of health and economical burden.


Histologically, the heart presented diffuse eosinophilic infiltrates located around perivascular structures and focal myocyte necrosis with numerous interstitial eosinophils admixed with histiocytes.


Therefore, it is reasonable to conclude that: 1) 2-CdA can induce durable complete remission in MCD patients but unfortunately it cannot cure the disease; 2) the possibility that 2-CdA may accelerate the transformation of MCD to NHL cannot be ruled out.


Bladder contracture: review for intravesical bacillus Calmette-Guerin complication.


Transient global amnesia after clioquinol: five personal observations from outside Japan.


These patients developed cutaneous sarcoidosis about 3 months after the beginning of the combination therapy.


In a fifth case a 14-year-old boy developed papilloedema after taking a short course of tetracycline for bronchitis.


In 15 to 20% of patients, adverse effects may involve other organ systems.


Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.


The correlation between the haematologic and pneumologic toxicity is discussed.


Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5-fluorouracil and levamisole may have been caused at least partly by levamisole.


We report a case of NEH masquerading as cutaneous vasculitis in a woman receiving cyclophosphamide for lupus nephritis.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


The hemodiafiltration procedure with a polysulfone membrane was performed 3 times.


We here report the first case of psoriatic arthritis which developed lung cancer.


Currently, patients who suffer from this do not need mechanical ventilation, and the toxicity can be difficult to diagnose when it occurs in patient with an illness producing pulmonary manifestations.


Cessation of sulfasalazine and administration of steroids led to dramatic improvement.


The most serious dental side effect of bisphosphonate treatment (particularly when it is administered intravenously) is, paradoxically, osteonecrosis of the mandible or the maxilla represented by exposed nonhealing bone.


The posttransplant course was complicated by several infection episodes and one episode of acute cellular rejection grade 2.


The fifth patient exhibited paraesthesia and agitation caused by olanzapine that was misdiagnosed as psychotic agitation.


CK and myoglobin levels normalized a week later.


Possible serotonin syndrome associated with clomipramine after withdrawal of clozapine.


Thus, lithium intoxication is a frequent complication of chronic lithium therapy.


Perforated gastric ulcer in an asthmatic treated with theophylline and steroids.


Prosthetic valve endocarditis caused by metallo-beta-lactamase-producing Pseudomonas aeruginosa.


In this case, interferon alpha induced polymyositis and cardiomyopathy is diagnosed in a 33-yr-old male patient with history of chronic hepatitis B.


There was no recurrence the following year.


Steroid rosacea in children.


Establishing causality in pediatric adverse drug reactions: use of the Naranjo probability scale.


In case 2, a 25 mg reduction in the total daily dose of sertraline resulted in halving of the lamotrigine blood level even though the lamotrigine dosage was increased by 33%.


Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.


Implantation of ventriculoperitoneal shunts in the precoronal position is generally accomplished using a retroauricular incision for subcutaneous tunneling.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


Supravenous hyperpigmentation in association with CHOP chemotherapy of a CD30 (Ki-1)-positive anaplastic large-cell lymphoma.


These 4 patients tolerated the drug well.


No hemodynamic instability or cardiac or renal sequelae were associated with the large, inadvertent bolus in our patient.


Acute liver dysfunction complicated with uncontrollable glycemia due to insulin antibody: successful treatment with glucocorticoid and lispro insulin.


Some days after the administration of a third bolus of ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) a patient affected by immunoblastic lymphoma underwent a neurotoxic crisis.


Gastrointestinal disturbances were reported in six patients, and hypotension in six.


Physiologic data were analyzed with an analysis of variance, with the Kruskal-Wallis test used for nonparametric data.


We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.


Chronic pain was assessed clinically by means of a visual analog scale (VAS) before and 12 weeks after the start of the milnacipran treatment or at the time the drug was stopped.


Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.


We describe a patient with rheumatoid arthritis treated with gold salts, who developed bilateral interstitial pulmonary abnormalities and showed a dramatic response on corticosteroid therapy.


Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.


We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.


The results of histopathologic examination of the colonic mucosa suggested ulcerative colitis.


Immediate surgical management became necessary.


The differential diagnosis, risk factors, potential contributing factors, and the successful management of the complications with our positive patient outcome are discussed.


Little hematologic and no gastrointestinal or central nervous system toxicity was experienced.


A number of studies have shown that hyperuricaemia is associated with an increased incidence of coronary heart disease.


We conclude that immunological dysfunction resulting from the thymectomy contributed significantly to the subsequent development of PRCA, SLE, and IPH in this patient.


Similar peripheral nerve histology was seen in a parallel animal study in which the severity of the neuropathy was dose-related.


Five months after the patient's erythropoietin therapy was discontinued, his A1C value increased to 8.8%, leading us to conclude that management of the insulin dose may have been different without the falsely lowered A1C levels.


We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.


To put this into perspective, total aplasia of red blood cells for 40 days would result in a drop of 30-33% in the red blood cell count.


It is concluded that the aforementioned pathological manifestations were due to chemotherapy and included a pulmonary adverse reaction, a feature never previously associated with oxaliplatinum and 5-fluorouracil regimens.


Coronary artery perforation especially type III is a rare and catastrophic complication of percutaneous coronary intervention.


Cyproheptadine for intrathecal baclofen withdrawal.


Case report of withdrawal dyskinesia associated with amoxapine.


This report describes an individual with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day (0.02 mg/kg/day) to treat aggression, self-injurious behavior, property destruction, and screaming, which was measured with a 15-minute partial interval recording measurement method.


Paclitaxel was an effective therapy in this setting.


Corneal interface abscess after excimer laser in situ keratomileusis.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


Amoxapine, a new antidepressant, appears in human milk.


Over the next 15 h she developed progressive hemolysis and methemoglobinemia.


Primary thrombocytosis and secondary causes were excluded.


CONCLUSION: Since these drugs are used widely in the pediatric transplantation population, this report serves to heighten awareness of this debilitating phenomenon, and to stress the importance of exercising caution when sirolimus and tacrolimus are administered in combination to pediatric patients.


His symptoms resolved within 10 minutes.


A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.


Hemorrhage from a falx meningioma after internal use of low-dose aspirin.


There were no differences in reported nausea between SC and TSC groups, but nausea was more common in the SC group than in those without TSCs.


Reactivation of hepatitis B virus infection with persistently negative HBsAg on three HBsAg assays in a lymphoma patient undergoing chemotherapy.


This strategy resulted in a disappearance of clinical symptoms and a negative positron emission tomogram.


Her serum potassium level was 13.1 mEq/L and HCO3- was 16 mEq/L.


Because psoralens sensitize skin to ultraviolet A light, phototoxic reactions are the most frequent adverse effect of this treatment.


We report a 45-year-old Chinese man with CML and chronic hepatitis B virus infection, on imatinib treatment, presenting with herpetic rash and acute liver failure.


Another important concept behind some medical myths is the overreliance on case reports or authoritative text.


This case indicates that the potential for beta-blocker-induced hyperkalemia exists even with topical appreciation.


We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.


A retrospective study was conducted of 40 loperamide poisoning cases recorded at the Centre National d'Informations Toxicologiques Veterinaires.


RESULTS: Eight out of nine patients were abstinent under quetiapine over a period of 2-7 months.


The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.


Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNalpha) have all been associated with renal dysfunction.


A diagnosis of pustular psoriasis was made clinically and histologically.


Regression of invasive conjunctival squamous carcinoma in an HIV-positive patient on antiretroviral therapy.


The pathogenesis of tardive dyskinesia is distinct from and may be functionally opposite to that of parkinsonism.


METHODS: Interventional case report and literature review.


L-Thyroxine-induced leukopenia in a patient with Hashimoto's disease: involvement of suppressor-cytotoxic T cells.


Blood and urine samples were collected over a 98 h period for monitoring the efficacy and adequacy of FAB treatment.


The Food and Drug Administration (FDA) licensed Rh(o)(D) immune globulin intravenous (anti-D IGIV) on March 24, 1995, for treatment of immune thrombocytopenic purpura (ITP).


Disopyramide (Norpace)-induced hypoglycemia.


Sural nerve biopsy revealed mild demyelination and many inclusion bodies in the axoplasm and in Schwann cell cytoplasm.


Chryseobacterium indologenes was isolated from the blood cultures of an oncological patient with a totally implantable device.


Disturbances of the IAN and mental nerve will predominantly give sensitivity symptoms in the soft tissue of the lower lip and chin.


These observations suggest that caution should be exercised when considering administration of CSFs to patients with HS and similar metabolic storage diseases.


During the course of therapy, the patient showed rapid onset of oliguria, dizziness, edema, and a pre-shock state.


The patient presented with fulminant microangiopathic hemolytic anemia and thrombocytopenia within 48 hr of initiating therapy with trimethoprim-sulfamethoxazole.


Radiation recall pneumonitis induced by gemcitabine.


She was found to have diffuse pulmonary infiltrates on chest radiograph and a marked peripheral eosinophilia without leukocytosis.


We report an unusual case of simultaneous transitional cell carcinoma of the renal pelvis and distal ureter without transitional cell carcinoma of the bladder occurring after chronic cyclophosphamide therapy for nonHodgkin's lymphoma.


In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.


The mass had secured an additional vascular supply from the transverse colon and omentum.


Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.


A patient developed cholestatic hepatitis while being treated with nitrofurantoin.


We report such a case in a morbidly obese laboring parturient after receiving combined spinal-epidural labor analgesia.


Most primary HC infections are subclinical or self-limited.


The Keyes technique and self-inflicted injuries.


We report two cases in unrelated UCBT setting and added the following new information to the literature: (i) EBV-related PTLD can be presented late in recipients of unrelated UCBT; (ii) in contrast to reported literatures that PTLD is a serious complication with unfavorable outcome, especially in monomorphic form, our cases showed that the clinical course may be relatively benign if treatment is initiated promptly.


Herein we present a case of adenomyosis in the broad ligament with unusual gross features.


There was no recurrence of thrombosis or bleeding events during therapy with danaparoid.


Careful pretreatment screening and rigorous monitoring patients are recommended to help prevent this life-threatening event.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.


CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.


Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.


Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.


Does the use of insulin in a patient with liver dysfunction increase water retention in the body, i.e. cause insulin oedema?


The immunoglobulin G (IgG) obtained from the TRAb-positive serum of the patient elicited no thyroid hormone-releasing activity in cultured human thyroid follicles, whereas all IgGs obtained from untreated Graves' disease elicited positive results.


A 66-year-old man with four indwelling ventriculoperitoneal shunts for multiloculated hydrocephalus from a complicated case of meningitis a year before developed shunt infection based on a syndrome of fever, drowsiness, and cerebrospinal fluid neutrophil pleocytosis in the background of repeated surgical manipulation to relieve successive shunt blockages.


To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.


DESIGN: Case series.


Drug-induced pleural disease.


Physical examination and laboratory data revealed no significant changes.


RESULTS: High-contrast round bodies suggestive of Acanthamoeba cysts, as previously described, and irregular forms suggestive of Acanthamoeba trophozoites were found by tandem scanning confocal microscopy.


At delivery, there were severe brachycephaly, hypoplasia of the anterior cranial base and the midface as well as synostoses of both coronal and metopic sutures.


This report described a case of scrofuloderma that developed in the bilateral inguinal regions during treatment of bullous pemphigoid with systemic corticosteroid.


The case reports demonstrate that significant and potentially dangerous side effects from timolol maleate occur as a result of inadvertent overdosing.


Derivatives of Imidazoline usually act to stimulate peripheral alpha2 receptors causing vasoconstriction.


The effect was retained with a purified IgG fraction and almost eliminated with IgG-depleted serum.


The utilization of abdominal or pelvic radiation has been extended, and the incidence of radiation enteritis appears to be increasing.


Marked hyperkalemia was observed during and immediately after an infusion of arginine monohydrochloride in two patients with severe hepatic disease and moderate renal insufficiency.


Being in remission with his UC the patient died 14 months later of staphylococcus aureus sepsis despite intense antibiotic treatment.


Continuous bladder irrigation of a 1% alum solution is a simple and generally safe method of chemical cautery to treat the bleeding urothelium.


They suffered from severe (one case) or moderate (two cases) hemopoietic form of acute radiation sickness (ARS).


Fortunately, no lower back pain has recurred.


The T315I BCR-ABL mutation mediates resistance to imatinib, nilotinib, and dasatinib.


The constellation of chronic cough, dyspnea, and hemoptysis can include a broad range of differential diagnoses.


Crumley).


After discontinuation of citalopram therapy, serum sodium concentrations normalized.


Serotyping revealed that the two episodes of bacteraemia were caused by different strains.


Although it is unclear which of several possible contributing factors was responsible for the ventricular fibrillation, recommendations are appropriate to minimize the risk in infants with WPW.


For patients who suffer from osteogenic sarcoma and have anaphylactic reactions to MTX, this desensitization protocol will allow these patients to continue with needed therapeutic or palliative chemotherapy.


As suggested by the three clustered cases, this heretofore undescribed association between sudden unexpected cardiac death and thrombolytic therapy for AMI in patients with seropositive, corticosteroid-dependent RA suggests that further study and observation are needed.


A proliferation test and an evaluation of TNF-alpha and interleukin (IL)-6 production from PBMC in presence of insulin were studied.


This patient's wound care regimen began with silver sulfadiazine and wet-to-dry dressings, modified to initial cleansing with a zinc-saline solution, followed with application of a zinc-saline wet dressing, impregnated with an aluminum hydroxide ointment.


Strongyloidiasis and aseptic meningitis occurred in a renal transplant recipient who was receiving immunosuppressive drugs.


The patient displayed several characteristics of NMS during therapy with olanzapine, including fever, elevated creatine kinase level, leukocytosis, and mild muscle rigidity.


Despite several doses of intravenous rasburicase (2 doses of 0.1 mg/kg and 4 doses of 0.2 mg/kg), as well as aggressive supportive therapy, the infant died of complications arising from uncontrolled TLS.


CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.


Aminocaproic acid treatment of recurrent postoperative hyphemas.


Additional predisposing factors were the patient's age and difficulty in urination due to benign prostatic hypertrophy.


We report a case of dermal alternariosis occurring in a woman treated with corticosteroids for dermatomyositis.


Case management of the anemic patient epoetin alfa: focus on aluminum management.


Successful treatment of florid cutaneous warts with intravenous cidofovir in an 11-year-old girl.


To our knowledge, this is the first clear report of reactivation of "latent" Histoplasmosis after anti-TNF-alpha therapy.


First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.


The histological findings were a benign colonic ulcer with the infiltration of inflammatory cells, mainly lymphocytes.


The multifocal electroretinogram returned to normal after the full-field electroretinogram had done so.


His serum calcium was found to be 18 mg/dl.


The symptoms occurred with a delay of 3-4 h after the treatment x2 daily.


Immunoglobulins were not found in the patient's serum and the red cells were coated with C3 only, suggesting an "innocent bystander" reaction.


Carboplatin is a chemotherapeutic agent approved in the first-line setting of numerous malignancies.


The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


Unexpected and prolonged akinesia: a case report.


Fever and neutrophilic alveolitis caused by a vanadium based catalyst.


Treatment included drug discontinuation, steroids, fresh frozen plasma, hemodialysis, absorption chromatography, plasmapheresis, and various combinations thereof.


Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.


Recurrent palmar-plantar erythrodysaesthesia following high-dose cytarabine treatment for acute lymphoblastic leukemia.


Renal artery rupture secondary to pretransplantation Candida contamination of the graft in two different recipients.


After 6 weeks of oral Sildenafil treatment, her serum albumin and the fecal alpha-1-antitrypsin levels normalized, and her exercise tolerance had increased.


Treatment included double-volume exchange transfusion, phenobarbital administered prophylactically, and folinic acid rescue 18 mg every 3 hours for 16 doses.


WE from thiamine deficiency can occur as a result of cessation of MVI in the TPN infusion.


Caution is therefore recommended in using ACE inhibitors to treat hypertension in patients with ADPKD who are at high risk because of compromised renal function and massive cystic involvement.


We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.


Woman interrupted gestation, by labour induction.


We reviewed the findings for healthy volunteers/donors who developed haematological malignancies following PEG-rHuMGDF or G-CSF administration.


She was admitted to the authors' department with a deep corneal ulcer in the right eye for which she had been treated for 3 weeks with local antibiotics without any improvement.


There are two types of priapism; ischemic low-flow type or non-ischemic high flow, with differing etiologies.


Physicians should be aware that PLP can occur after initiation of paclitaxel.


After rapid correction of severe hyponatremia, a 36-year-old man developed osmotic demyelination syndrome (ODS), manifested neurologically by impaired cognition, extremity weakness, bilateral third cranial nerve palsies, and gaze-evoked upbeat and rotary nystagmus.


Inefficacy of high-dose transdermal fentanyl in a patient with neuropathic pain, a case report.


Impairment of salivary secretion as a further effect upon cholinergic autonomic innervation was detectable for months.


Ventricular tachycardia after ingestion of ayurveda herbal antidiarrheal medication containing aconitum.


This case illustrates two points concerning preoperative chemotherapy for locally advanced breast cancer: (1) The role of FNA v. tissue biopsy is examined.


RESULTS: A 50-year-old woman with diabetes and obesity who underwent vertical banded gastroplasty had postoperative complications, including refractory gastrostomy leakage, peritoneal and abdominal wall infections, and multiorganism sepsis despite intensive antibiotic therapy and surgical drainage procedures.


BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.


When it occurs, trichosporonosis usually is associated with hematological malignancies and, to the best of our knowledge, has not been previously reported in a liver transplant recipient.


It also emphasizes how minor changes in electrocardiogram can be overlooked on standard electrocardiograms.


Disseminated encephalomyelitis (DEM) is an inflammatory demyelinating disease that is common in children, but also appears in adults.


The potential role of serotonin in the development of this serious complication is discussed.


After the patient died, enteroviral RNA was also detected in his lungs, liver, and spleen, indicating a generalized infection.


These data suggest that cidofovir may be useful as adjuvant therapy for BKVN.


Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.


Because of the immunosuppressive drugs used after organ transplantation, there is an increased rate of certain infections and malignancies.


This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.


A postmortem liver biopsy revealed adenocarcinoma undergoing necrosis.


A patient with pemphigus vulgaris and serious side effects of steroid therapy was treated by exchange plasmapheresis.


This report aims to highlight the fact that single-pulse transcranial magnetic stimulation may provoke a seizure even in the absence of gross neurologic abnormality.


Although it is chronic, it is commonly associated with exacerbations and short periods of remission.


To our knowledge, this is the first case involving M. genavense infection in a patient with systemic lupus erythematosus.


Insulin-dependent diabetes mellitus associated with danazol.


In the second case, a woman suffering from a cholangiocellular carcinoma, end-stage renal disease was irreversible.


CONCLUSIONS: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objective visual field loss.


Abuse of salbutamol inhalers in young people.


At explant, all four systems had clots adherent to the surface of the tubing and connectors on the pump outflow side of the circuit.


A second episode of jaundice followed the intravaginal administration of a mixture of furazolidone and nifuroxime.


This case demonstrates that the rapid effect of intravenous dantrolene can be life saving in fulminant neuroleptic malignant syndrome.


This resulted in clinical improvement and controlled the progression of hemolysis and methemoglobinemia.


Based on these data, authors have previously exposure is confirmed despite a lack of any pattern to the defects reported.


Although HCV-RNA reappeared in the serum at 3 months, the patient had continued ALT normalization and histological improvement with follow-up of over 26 months to date after the initiation of the combination therapy.


However, marked pruritic infiltration developed within 24 h, progressing to coalescing eczematous lesions over the following 2 days.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).


In adverse reactions with shock, tripled tryptase values can support a diagnosis of anaphylaxis.


The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.


All but one patient presented with afebrile seizures.


A TDM consultant discusses the case in the context of toxicokinetic analysis.


Recalcitrant osteomyelitis following tooth extraction in a case of malignant osteopetrosis.


BACKGROUND: Three to five per cent acetic acid is commonly used in the field of gynaecology for colposcopic examinations of the cervix.


Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy.


A unique patient with adrenal insufficiency is reported who received corticosteroids intravenously and then had multiple lesions develop that were similar to focal lipoatrophy as known to occur secondary to faulty intradermal injections of corticosteroids.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


Consequently, inadvertent placement of the needle into the vertebral artery, thyroid, neural tissues, or esophagus can occur with the fluoroscopic or blind approach.


Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


SETTING: Adult intensive care unit (ICU) at Dartmouth-Hitchcock Medical Center.


BACKGROUND: Dyskinesias are a transient but severe complication of subthalamotomy in some patients.


These remained the only agents for the next 50 years.


Subsequently, he developed symptoms typical of GHD and, after biochemical confirmation, GH replacement was commenced.


Organ transplant recipients are generally considered to be at greater risk for developing malignant disorders because of prolonged immunosuppression for organ grafting, but acute leukemia is a rare complication after organ transplantation (0.2 -2.5%).


Conversion of ischemic to hemorrhagic infarction has been shown to occur experimentally.


Despite intensive supportive measures and specific therapeutic attempts, all three patients eventually died of septic shock.


OBJECTIVE: To report a case of toxin-positive Clostridium difficile-induced colitis (CDIC) after use of clindamycin phosphate vaginal cream.


Acrodermatitis enteropathica with SMON almost always has a high occurrence of visual impairment, but other sensory disturbances are slight or absent, while common adult SMON is just the opposite.


Thrombolytic therapy in acute cerebral infarction complicating diagnostic cardiac catheterization.


Pancytopenia is a rare complication of the thionamide therapy reported secondary to aplastic anemia, the bone marrow being invariably hypocellular.


RESULTS: Microscopic examination of smears revealed Acanthamoeba cysts and non-nutrient agar showed a significant growth of Acanthamoeba.


Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).


The patient then received combined cataract and glaucoma surgery.


Successful treatment of tardive and spontaneous dyskinesias with corticosteroids.


The pacing system was removed in one patient 13 months postoperatively because of persistent pericarditis; one patient died of an unrelated cerebral hemorrhage 13 months postoperatively.


However, whether or not the microgranulations were bacterial colonies, infection did not recur during a 2-year follow-up period.


Its etiology has still not yet been fully resolved.


The tolerance of sunitinib in the setting of dialysis can be challenging as these interventions can have synergistic side effects.


Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.


While still receiving the drug or shortly thereafter, two patients were found to have abnormal dark-adaptation curves, with elevations of either cone or rod thresholds, or both.


We report 2 cases of severe, persistent erythema multiforme, treated with thalidomide, with complete disease suppression in both cases.


Of the 16 patients, including the 1 reported here, only 3 displayed significant shortening of the agranulocytic period after treatment.


He was successfully transplanted.


We present the case of a patient who had undergone cholecystectomy previously, but in whom morphine given in the Emergency Department precipitated pain consistent with biliary colic; the pain resolved promptly after administration of naloxone.


RESULTS: The treatment regimen resulted in two complete regressions, five partial responses, and one mixed response, and two patients did not respond to the treatment.


Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.


Sirolimus-associated hepatotoxicity in the kidney graft recipient.


OBJECTIVE: To report a case of HIV-related lipodystrophy with a rapid onset of symptoms from epidural lipomatosis in the wake of protease inhibitor and steroid treatment.


Timolol side effects and inadvertent overdosing.


Reactivation of sarcoidosis during interferon therapy.


A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline.


We also provide a literature review regarding thionamide-induced ANCA-associated vasculitis.


We present a 16 month-old previously healthy boy with refractory hypercalcemia due to an overdose of an over-the-counter vitamin supplement.


A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.


The pathogenesis of chemotherapy-associated thrombotic microangiopathy (C-TMA) has not been established.


This report describes 2 generations of a family with symptoms of sensory overstimulation that exhibit a potassium sensitivity similar to that seen in hypokalemic periodic paralysis.


Fungal arthritis and osteomyelitis are rare and documented mainly in immunocompromised or neutropenic patients.


CASE REPORT: A case history of unanticipated radiation-induced bilateral optic neuropathy, 18 months after induction chemotherapy and radiation therapy for a locally advanced nasopharyngeal carcinoma, is presented.


Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.


After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs.


Triad of severe abdominal pain, inappropriate antidiuretic hormone secretion, and disseminated varicella-zoster virus infection preceding cutaneous manifestations after hematopoietic stem cell transplantation: utility of PCR for early recognition and therapy.


PATIENTS: Two infants and three children inpatients receiving amphotericin B.


Anaphylaxis to calcitonin.


The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.


Use of somatostatin for complications occurring after liver transplantation.


RESULTS: All three patients responded to risperidone and experienced no extrapyramidal side effects.


Anterior ischemic optic neuropathy: a complication after extracorporal circulation.


The proliferating cells were of T lineage and further typing demonstrated that they bore the OKT8 antigen.


The second patient was a 4-day-old neonate with congenital precursor-B cell acute lymphoblastic leukemia who presented with spontaneous TLS complicated by renal dysfunction.


An 18-year-old female with alpha-1 antitrypsin deficiency underwent living donor liver transplantation and presented 6 months later with a liver abscess.


Platinum agents and secondary myeloid leukaemia: two cases treated only with platinum-based drugs.


Close monitoring for the development of a deep thrombosis of the popliteal vein is required.


During the three years of follow-up, both pulmonary sarcoidosis and hepatitis C have not recurred.


Neurotoxicity of intrathecal administration of amphotericin B.


Electrical stability was achieved and the patient was discharged on propranolol 400 mg/day.


The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.


Therefore, we recommend that regular examination for TD using the activation procedure should be performed in patients who use clozapine on a long-term basis.


Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.


Clinical trials of patients treated de novo, in first relapse, and with resistant disease have achieved a high rate of complete remission (CR).


A review of the literature revealed that Paecilomyces species are an infrequent cause of disease in transplant patients, with skin and soft tissue infections being the most common presentation.


The patient appeared to be homozygous for the dibucaine resistant gene, having only 15% of normal activity in his serum.


Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.


In the second patient, a mild augmentation of liver enzymes occurred, followed by normalization in a few days.


The leukemic blasts were examined by morphological, immunohistochemical, cytogenetic, and molecular genetic analyses.


The neurologic toxicity can vary from being mild to severe and prolonged.


One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).


The optimal treatment is not well defined.


A significant feature of this group is its resistance to almost all presently available antibiotics including penicillin, the cephalosporins, and the aminoglycosides.


The targeted therapy gefitinib was prescribed 2 years after diagnosis, producing a very good partial response.


Transplant physicians should be aware of this unusual pathogen and the potential for both persistent line-related sepsis and possible septic arthritis.


Atypical antipsychotic induced hypothermia is a rare adverse effect that may present with mild to severe symptoms.


Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas.


Case report.


We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.


1. Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment (mean 0.62 +/- 0.15 mg/day) compared with during the period of high-dose period (mean 1.08 +/- 0.28 mg/day).


Patients whose trigeminal branches have been subjected to repeated surgical procedures and who have relentless unilateral face-jaw pain should be classified as having chronic traumatic trigeminal neuralgia.


A percutaneous liver biopsy obtained from one of the patients showed ultrastructural abnormalities consistent with a toxic hepatitis and hepatic congestion.


Nasogastric glutamine-supplemented tube feedings were well tolerated both in the hospital and at home.


Furthermore, 8-hydroxy-deoxyguanosine (8-OH-dG) was prominently increased in mitochondrial and nuclear DNA.


The patient died 5 months after MAHA was diagnosed.


The presentation in humans appears similar to that in dogs where cardiac arrhythmias occurred at doses of 5-15 mg/kg.


Attention should be directed towards prevention by the identification and immunisation of at risk patients prior to transplantation.


In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.


The common systemic diseases that may give rise to gynecomastia were excluded.


Extrapulmonary disseminated tuberculosis also involving bone and liver was eventually diagnosed and proven by means of specific polymerase chain reaction assay.


We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).


The Patient conceived 2 years after completing therapy and gave birth at term to a normal infant.


This therapy was curtailed after three cycles because of nausea, asthenia, and neuropsychological deterioration.


Over the course of 2 months, the wound healed with systemic antibiotics.


In all cases, ACE-inhibitor therapy either predisposed the patient to or precipitated the acute event.


A Meckel diverticulum is an embryonic remnant of the vitellointestinal duct.


Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.


Syncope induced by propranolol in hypertrophic cardiomyopathy.


Further studies are necessary to evaluate whether the study of HLA antigens may be a very useful tool to detect the patients with a predisposition to develop autoimmune thyroiditis, in order to make a early diagnosis of thyroid disorders during the IFN-alpha treatment.


The effects of proton pump inhibitors on the pharmacokinetics of atazanavir and amprenavir (administered as fosamprenavir) were rigorously evaluated in healthy volunteers in two studies, but formal studies in persons infected with human immunodeficiency virus (HIV) are lacking.


CONCLUSIONS: The administration of prostaglandin E1 to neonates can cause gastric-outlet obstruction due to antral hyperplasia.


Neuroleptic malignant syndrome due to atypical neuroleptics: three episodes in one patient.


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.


After discontinuing those drugs, the ST segment elevation in leads V(1) and V(2) became reduced.


Joint infections by mycobacteria are clinically indistinguishable from those caused by more common bacterial pathogens and, therefore, diagnosis is often delayed.


We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.


We report a case of MALA in which acute renal failure resulting from dehydration secondary to diarrhea and poor oral intake likely caused MALA.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


CONCLUSIONS: These findings suggest that, in patients who are susceptible, the periocular or systemic absorption of inhaled corticosteroids may be sufficient to produce CSC in humans, supporting previous hypotheses regarding the pathogenesis of the disorder.


OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.


We report a bacterial corneal ulcer that occurred in a patient who had worn extended-wear rigid gas-permeable contact lenses on a 1-week cycle for 9 months.


We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.


He was treated with penicillin.


We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.


Although other nitrites induce methemoglobinemia, exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia.


Glucagon is considered the drug of choice for treating bradycardia and hypotension encountered during beta-blocker poisoning.


Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin-induced rhabdomyolysis.


The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.


On two occasions, within 48 hours of treatment, the patient developed acute leukopenia.


CONCLUSION: Fungal infection of ICDs is a rare but serious complication of device implantation that must be treated aggressively with complete hardware explantation and prolonged antifungal therapy.


Electroconvulsive therapy in myasthenia gravis.


The patient was discharged from hospital after 120 days with normal liver function and recovered bone marrow.


The authors report five cases of tremor related to itraconazole therapy, which occurred within 1-12 months of initiating treatment and resolved gradually following itraconazole withdrawal.


We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.


Internists will need to be increasingly aware of and prepared for this pharmacologic complication.


The temporal and dose-response relationships suggested a possible association between the depressive symptoms and corticosteroid.


Recently, the patient has exhibited signs of tardive dyskinesia.


New strategies must include the development of completely fibrin-specific thrombolytics and drugs that may rapidly reverse the systemic and local clotting disorder.


Prednisone doses of 1 mg/kg/d have been suggested.


A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.


BACKGROUND: Methotrexate (MTX) is a folic acid antagonist used in high doses as adjuvant chemotherapy for osteosarcoma.


A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.


After initial stabilization, the patient was discharged with warfarin (target INR = 2.5-3.5) together with beta-blockers, statins and metformin.


However, several case reports have suggested that clozapine could also cause TD.


Sequencing studies revealed the presence of mutations in viral isolates obtained after clinical resistance was observed.


TSH levels were normalised with the addition of mouse serum to the patient's sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.


Thus, even after a long hiatus, it may not be safe to exceed the recommended maximum cumulative dose level of adriamycin.


Lithium was withdrawn in each case.


Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.


The 69-year-old patients recovered rapidly after oral administration of fluids and sodium bicarbonate.


A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.


The complete recovery from anagen effluvium is difficult to explain, but it could have been because of the early initiation of corticosteroid.


Both patients with NMS had been treated with neuroleptics, including CYP2D6 substrates.


However, this aggressive chemotherapy has not offered any advantage because of an unacceptably high treatment-related morbidity and mortality (17%).


Adjuvant corticosteroid sparing therapy can also be associated with significant morbidity.


Six days after taking erlotinib, a chest radiograph showed rapid progression of reticular infiltration in both lung fields.


Nasal septal perforation in a patient with allergic bronchopulmonary aspergillosis and rhinitis on long term corticosteroids.


We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period.


Little attention has been paid to infertility in men with epilepsy and little information exists about the mechanisms by which anti-epileptic drugs affect spermatogenesis or sperm function.


We present a case of a 58-year-old female patient with Graves' disease who developed AA in the third exposure to methimazole (MMI).


Acetazolamide (Diamox) is a carbonic anhydrase inhibitor commonly used in patients with glaucoma in order to reduce intraocular pressure.


Even after a strict warning, he took another quinine tablet that evening, which triggered his fifth episode of severe thrombocytopenia, and confirmed the etiology of quinine-induced thrombocytopenia.


In conclusion, the diagnosis of aflatoxicosis takes cognisance of geographical location, past events, staple diet and clinical features to exclude other infections.


Lichen planus and acne provoked by gold.


Follow-up ranged from 3 to to15 months.


CASE REPORT: A 67-year-old female presented with acquired long QT interval syndrome with a refractory ventricular arrhythmia.


We report a male patient with advanced AIDS who developed hypercalcemia 2 weeks after institution of rhGH therapy.


Herein, we report the case of a 73-year-old woman who underwent major coronary surgery and developed fatal systemic venous thrombosis after recombinant factor VIIa was used in an attempt to control her severe postoperative bleeding.


Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation.


Acute renal failure is a rare complication following the administration of intravenous immunoglobulin (IVIG).


Donepezil in the treatment of opioid-induced sedation: report of six cases.


Although studies have shown a relationship between abnormal scapular motion and subacromial impingement, it has been unclear whether the altered scapular biomechanics represent a cause, or consequence, of impingement.


Elevated levels of ammonemia, gamma-glutamyl transpeptidase, alkaline phosphatase and IgA were detected.


Despite these measures he appeared to have progressive lymphoma.


This report describes a unique path of spread of testicular cancer which also appears to spontaneously mature at the metastatic site.


Managing ergot-induced gangrene: the anesthesiologist as a key player.


Since early symptoms of the toxic effects of theophylline can mimic peptic ulcer disease, cimetidine might be prescribed for the gastrointestinal symptoms with subsequent worsening of theophylline poisoning.


Mequitazine seemed to play a part similar to chlorpromazine, and absence of mequitazine-induced photosensitivity may be due to a relatively low dosage of the drug.


The patient could be disconnected from the ventilator and within <24 h was extubated.


Metformin-associated lactic acidosis (MALA) is a serious metabolic complication that occurs because of metformin accumulation in patients who become dehydrated or developed acute renal failure.


We report a case with chronic hepatitis C (CHC) who developed sarcoidosis after the treatment by interferon alpha and ribavirin.


Sonographically guided percutaneous thrombin injection is a minimally invasive and highly successful treatment of arterial pseudoaneurysms.


The aim was to determine the source of the recurrent lesion based on its morphology and the patient's verbal history.


Coexistence of hereditary angioedema and Turner's syndrome.


After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.


Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.


He was taken to surgery 8 days after cefazolin was discontinued and received perioperative prophylaxis with cefoxitin (total dose 3 g).


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


When managing TLS in infancy, clinicians must consider the relative degree of renal immaturity and its predisposition toward metabolic derangements.


The patient had been receiving factor VIII:C clotting factor concentrates (mean 60,000 U/year) since 1975.


The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.


This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.


Depigmentation has been described with local steroid injections for other dermatologic conditions, but has not been reported previously with treatment of infantile ocular adnexal hemangiomas.


She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.


The patient expired 13 d after admission.


He presented with multiple masses in the right lobe of the liver and a metastasis in the left adrenal gland.


In addition, ethambutol rarely causes visual loss during the early period or when given at lower doses.


Polymerase chain reaction analysis of the serum showed dramatic decreases in the viral DNA copy number and revealed large viral concentrations prior to the skin manifestations.


RESULTS: The material from inside the lumen of the catheter was analyzed using x-ray spectroscopy and a scanning electron microscopy.


Pulmonary function test showed a mild restriction.


We report a myeloma patient who developed severe paralytic ileus during bortezomib therapy, which presented in the context of progressive constipation without other known causes and which regressed promptly with medical management after drug cessation, suggesting a direct causal relationship.


The purpose of this review is to increase awareness among physicians and other health care professionals that DIC may be a rare but potentially severe complication of anti-D IGIV treatment.


Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.


We report a case of a patient with mild chronic renal insufficiency who had been taking simvastatin for over a year and developed acute weakness within 3 weeks after the start of treatment with colchicine for acute gouty bursitis.


Seven patients with rheumatoid disease were given the iron-chelating drug desferrioxamine (DFX) to evaluate its possible anti-inflammatory effects.


We postulate that the bolus of sulprostone resulted in possible coronary spasm that resulted in cardiac arrest.


Its diagnosis is critical to avoid future exposure to aromatic anticonvulsants.


Five months later, he presented with watery diarrhea and abdominal distention.


In a review of the literature no report of a similar case was found.


Three of 50 patients treated with isotretinoin (1 mg/kg/day) for cystic acne complained of poor night vision and/or excessive glare sensitivity.


This represents the first reported case of syphilitic meningitis in a lupus patient.


Clinicians should be aware of this potential adverse effect of tigecycline.


Follow-up brain MRI of these 2 patients revealed that the lesions in the thalamus and brainstem disappeared or resolved almost completely.


Cephalexin rash in infectious mononucleosis.


In both patients seizures were associated with discontinuation of short-term agents with high antimuscarinic properties.


The exact mechanism of IVIG-associated acute renal failure remains unclear.


We concluded that irregularities on the surface of the lens, such as a manufacturer's trademark, provide a focus for synechiae.


Transient bilateral blindness and posterior reversible encephalopathy syndrome: a rare complication of enuresis treatment.


OBJECTIVE: To test the efficacy and safety of a nicotinic, acetylcholine antagonist, mecamylamine, in the treatment of Tourette's syndrome (TS).


We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.


Halothane hepatitis and prompt resolution with methionine therapy: case report.


The medical examiner's report indicated death caused by fluoxetine toxicity.


This drug is a semisynthetic ergot alkaloid, one of a class of drugs that is associated with fibrotic disorders.


Radiation enteritis: a rare complication of the transverse colon in uterine cancer.


We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate.


Lithium may help correct a chemical imbalance in the brain; however, it has a comparatively narrow therapeutic index.


Herein we document the unusual association of focal nodular hyperplasia with use of a synthetic anabolic androgen.


The pharmacokinetic synergism of this combination may be hazardous for some patients.


Theophylline intoxication following viloxazine induced decrease in clearance.


Two dogs with systemic nocardiosis are presented and the pathobiology, diagnosis, and treatment of nocardial infections are discussed.


An investigation was carried out to try to find the source of malaria infection, which is believed to be the blood or blood products that he received during his initial acute illness.


Recently, we started to evaluate cardiac parameters in medicated patients with schizophrenia using power spectrum analysis of heart rate variability.


The concentrations of quetiapine in these cases are 6-16 times greater than the upper reported therapeutic range (0.1-1.0 mg/L).


IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C.


CASE REPORT: A 44-year-old white man with a 23-year history of undifferentiated schizophrenia and obsessive-compulsive behavior had been treated with clozapine and clomipramine for several years.


There are no known deleterious effects on male fertility and on long-term teratogenic effect of isotretinoin.


Transient left homonymous hemianopsia and encephalopathy following treatment of testicular carcinoma with cisplatinum, vinblastine, and bleomycin.


Here, we report a case of angio-oedema associated with VRC therapy.


Detection of cytomegalovirus DNA from cytomegalovirus corneal endotheliitis after penetrating keratoplasty.


Giant blastoconidia of Candida albicans.


Fluoroquinolones have rarely been implicated in cases of toxic epidermal necrolysis.


Cornea transplantation was required in two of six eyes for dense central corneal scarring.


Though the relationship between asbestos exposure and malignant mesothelioma is firmly established, the relationship between asbestos exposure and lymphoma remains to be investigated.


Am J Med 1994: 96: 200-209) with multiple positive blood cultures for S. aureus and a mitral valve vegetation on transesophageal echocardiogram.


The striking chemical abnormality was an elevation of serum glutamic oxalacetic transaminase (SGOT) [aspartate aminotransferase (AST)].


Due to the severity of the rash, temozolomide was permanently discontinued.


Milk:plasma ratios were less than 1, although a higher ratio would be predicted.


Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.


The literature is reviewed and the case is discussed with special focus upon the duration of extrapyramidal side effects.


Serology showed that maternal CMV infection had been acquired at least four months before pregnancy.


OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.


Anticonvulsant hypersensitivity syndrome (AHS) is a rare, potentially fatal, idiosyncratic drug reaction characterized by fever, morbilliform rash, lymphadenopathy, hepatitis, and hematologic abnormalities.


Case report: life-threatening hypoglycaemia associated with sulfadoxine-pyrimethamine, a commonly used antimalarial drug.


Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.


The foreign body of a glue plug offers an ideal surface for bacterial colonization which becomes a reservoir for continuous bacterial dissemination.


Reye syndrome and juvenile rheumatoid arthritis in Michigan.


Poisoning with potassium cyanide is usually fatal because of the inhibition of cytochrome oxidase.


A month later this patient developed a fibula osteomyelitis due to the same germs.


The treatment was continued for 6 months without recurrence of the symptoms.


Her carbamazepine concentration decreased from 11.8 to 8.5 micrograms/mL; she also became pregnant at that time.


The problem of lindane.


Marked elevation of serum creatine kinase associated with olanzapine therapy.


It is important to consider possible cross-sensitivity of chemically related compounds even when they are administered by different routes.


The definition of standard of care varies amongst jurisdictions, but is generally defined as either that care which a reasonably well-trained physician in that specialty would provide under similar circumstances or as what would constitute reasonable medical care under the circumstances presented.


Portions of the UL97 and UL54 genes were amplified and compared to the AD169 wild-type strain.


This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder.


Three weeks later he developed severe respiratory distress.


A case of sinus arrest caused by opening the mouth under general anesthesia.


Biopsy findings showed an interstitial and air space lymphohistiocytic infiltrate with non-necrotizing granulomas, in the setting of negative cultures and special stains for microorganisms.


On indirect laryngoscopy, hyperadduction of the vocal folds was not the cause of the upper airway obstruction.


Despite the dramatic response of Hodgkin's disease to intensive chemotherapy, the skin lesion was rapidly transformed into squamous cell carcinoma in 10 weeks.


Myotonia associated with sarcoidosis: marked exacerbation with pravastatin.


Nephropathy, eosinophilia and fever were observed in an 18-year-old man being treated for staphylococcal septicemia.


Granulocytopenia was ascertained in seven, whereas agranulocytosis was diagnosed in two patients of this population.


RESULTS: Differences between the plaintiff's and defendant's experts' opinions are presented by utilizing the COAT literature.


HAART consisted of Lamivudine, Stavudine, Lopinavir and Ritonavir.


A 77-year-old man with previous myocardial infarction was admitted with chronic left heart failure and atrial tachycardia.


We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.


One case with proved amyloidosis and the second patient with ascites.


All patients recovered without sequels 3 to 6 months afterward.


We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).


A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.


The effect of varying concentrations of dextrose on the histamine content of the blood of normal, allergic, non-diabetic and diabetic, and non-allergic patients was studied.


The patient received two cycles of HDARAC over the course of a ten-week period.


Milnacipran is a novel serotonin noradrenaline reuptake inhibitor.


There was rapid spontaneous and complete regression of the eruptions, which was probably an expression of transient lymphomatoid papulosis in connection with MF.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


Neutropenic enterocolitis in breast cancer patient after taxane-containing chemotherapy.


RESULTS: No per- or postoperative complications were noted.


Although there are reports in the literature of a combined occlusion of the central retinal artery and vein, its occurrence following pars plana vitrectomy has not been described.


A pediatric case study of treprostinil overdose.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


Hiccupping caused by gastric distention, spicy foods, and neural dysfunction often resolves itself without any treatment.


Our case is the second one in which hemorrhage from a meningioma may have been induced by aspirin prophylaxis.


The patient presented to the emergency department 1 day after discharge from the hospital following total knee arthroplasty revision with acute-onset dyspnea and mild chest pain.


DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma.


For the second patient, hypophosphatemia was corrected, during hemodiafiltration, with the use of a phosphorus-enriched dialysate.


Thrombosis of mechanical valve prosthesis: thrombolysis vs surgical treatment.


Quantitative histologic study of iliac crest biopsy revealed marked increase in trabecular bone volume and osteoid volume, suggestive of fluorosis.


Interstitial pneumonia probably associated with sorafenib treatment: An alert of an adverse event.


PCNSL is a disease of the elderly, with the majority of patients being diagnosed in the 7th to 8th decade of life.


Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms.


Inhalation provocation test with DSCG aerosol, 4 months after stopping DSCG treatment, showed an immediate-type 1 response and urticaria.


Spontaneous coronary artery dissection.


Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.


We carried out a retrospective study of changes in the serological markers of HBV in this patient.


Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.


The authors found that the course and treatment of narcotic withdrawal in two neonates was complicated by prenatal exposure to high doses of diazepam, or Valium (Roche Laboratories, Nutley, NJ).


CONCLUSION: CBDCA and VP-16 in combination with radiotherapy should be considered an important treatment option for SCEC.


The case of an adolescent with PWS who experienced respiratory deterioration with an increase in rhGH and improvement with cessation of therapy is reported.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.


Laboratory test results revealed elevated liver function test values.


Delayed onset diffuse lamellar keratitis following enhancement LASIK surgery.


METHOD: Structured review of copperhead exposures reported to a regional poison center from 1997-2000.


On a compassionate basis, she then received oral posaconazole, 800 mg/d, in divided doses for 6 months.


He had underlying left carotid artery stenosis combined with bilateral preproliferative diabetic retinopathy.


After discontinuation of treatment with levamisole and a short course of corticosteroid therapy, the patient's condition dramatically improved.


We report a patient with progressive multifocal leukoencephalopathy (PML) after autologous stem cell transplantation (SCT) for non-Hodgkin's lymphoma (NHL).


When phenytoin was discontinued, valproate levels increased, and he progressively improved.


Hypertension was treated with acepromazine maleate (0.001 to 0.005 mg/kg of body weight) i.v., decreasing arterial pressures to reference values.


F VIII dosage was gradually reduced with advanced resorption of the haematoma and thereafter switched to prophylaxis (40 IU/kg bw 3 times weekly).


Symptoms subsided and pulses returned within a day of cessation of therapy.


In five patients, the eye that developed the tear was the second eye, whereas the first eye had a disciform scar.


Although the effects of hypomagnesemia have been frequently reported, little has been written to suggest a clinically important role for hypermagnesemia.


Eosinophilic gastroenteritis (EGE) is a rare condition of unknown etiology characterized by eosinophilic infiltration of the gastrointestinal (GI) tract.


He developed an inferior corneal epithelial defect and, later, a well-demarcated area of inferior corneal keratinization.


A 55-year-old woman with systemic lupus erythematosus was admitted with fever of unknown origin.


The hypercalcemia responded to discontinuation of rhGH and a single dose of intravenous pamidronate disodium and has not recurred in 8 months of follow-up.


She subsequently developed severe post-herpetic neuralgia requiring the recommencement of gabapentin and amitriptyline.


METHODS: Patients with chronic pain who voluntarily indicated that they used cannabis therapeutically completed a questionnaire about the type of cannabis used, the mode of administration, the amount used and the frequency of use, and their perception of the effectiveness of cannabis on a set of pain-associated symptoms and side effects.


Of these, 14 patients underwent castration (two patients) or received LH-RH analogue (12 patients) plus chlormadinone acetate for combined androgen blockade.


Acute renal failure in a patient receiving treatment with suramin.


Rhegmatogenous retinal detachment followed peribulbar injection in a patient with preexisting sympathetic ophthalmia.


This patient was started on aminoglutethimide 6 days prior to radiation therapy, for painful bone metastasis.


Tumor lysis syndrome was suspected and intensive hemodialysis was performed.


About three weeks into the therapy regimen, he complained of severe retrosternal chest oppression.


Viral antigen was not detected at the end of or during 3 of the 5 treatment courses and decreased to a low level following the 2 other courses.


When not to use what.


The therapies used for pyoderma gangrenosum include systemic corticosteroids, azathioprine, dapsone, mercaptopurine, sulphasalazine, sulphapyridine, thalidomide, cyclophosphamide, clofazimine, isotretinoin, immunoglobulins and cyclosporin.


The present report describes the typical profile of SILENT (persisting cerebellar dysfunction) and suggests measures to decrease the incidence of this potentially serious condition, for which no definitive treatment is available.


Two developed milder encephalopathy; one had no CNS depression at all.


Follow-up MRI at six months demonstrated no neuroradiological evidence of tumor recurrence in the site of operation.


ANCA was detected on admission; renal biopsy showed crescentic glomerulonephritis with focal necrotizing glomerulonephritis but no immune deposits.


This clinical course suggests that the sensorimotor polyneuropathy may have been caused by 5-ASA.


Ticlopidine is an oral antiplatelet agent frequently utilized in the treatment of cerebrovascular disease and is rarely associated with severe bone marrow suppression, typically aplastic anemia.


Report of two cases.


Abdominal computed tomography revealed the bumper to be buried in the abdominal wall.


After six weeks of additional anticoagulation, assessment by computed tomographic scan showed complete resolution of all thrombi.


Course of ovarian hyperstimulation syndrome in 19 intact twin pregnancies after assisted reproduction techniques, with a case report of severe thromboembolism.


A lethal complication of peripheral vein vasopressin infusion.


He became completely premorbid 2 weeks after administration of levodopa.


In this report we described a case of juvenile idiopathic arthritis patient who developed thymic enlargement (true thymic hyperplasia), mediastinal lymphadenopathy and pleurisy associated with systemic symptoms under Etanercept treatment.


Nine months later, she remains asymptomatic and shows no evidence of pulmonary decompensation.


Detailed investigations first revealed a low renin level without hypokalemia.


We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.


She had been receiving oral quinine intermittently for muscle cramps.


Radiation therapy was not given.


We report the management of two such patients by use of antiplatelet drugs for a vascular procedure.


It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.


A 62-year-old woman who was being treated for squamous cell carcinoma of the head and neck developed a chemotherapy-related hemolytic-uremic syndrome during the second cycle of neoadjuvant chemotherapy consisting of cisplatin, bleomycin, and methotrexate.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.