Mooren's ulcer is a rare disease of presumed autoimmune aetiology.


DESIGN: Interventional case report.


CONCLUSIONS: We present 2 patients allergic to cloxacillin with normal tolerance to other betalactam antibiotics, confirming that cross-reactivity among these antibiotics seems to be uncommon.


It is also available as a therapeutic agent (Xyrem) used for the treatment of daytime sleepiness or cataplexy associated with narcolepsy.


We describe a case of poisoning with 3,4-methylenedioxymet-amphetamine Ecstasy that presented with all the features suggestive of a fatal outcome, including a creatinine phosphokinase level markedly higher than any previously reported.


Cholesterol microembolization and stable renal function with continued anticoagulation.


Although they are rare, they may be life-threatening and should therefore be immediately recognized.


Tuberculous uveitis after treatment with etanercept.


Only after early oral and maxillofacial review and taking a thorough family history was C1 esterase-inhibitor deficiency diagnosed.


The man died from complications related to toxic epidermal necrolysis.


Ganciclovir resistance was suspected to be caused by both A594V of UL97 and Q578H of UL54, whereas foscarnet resistance was due mainly to Q578H of UL54.


DISCUSSION: Renal elimination is not a significant pathway of elimination for anastrozole, clearance of anastrozole is unchanged even in severe renal impairment.


The authors report a case of Balint syndrome with irreversible posterior leukoencephalopathy on MRI following intrathecal methotrexate and cytarabine.


The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.


Apart from direct invasion into nearly every organ in systemic infection, evidence suggests that immunological reaction also plays a role in the pathogenesis of the disease, including both uncomplicated and disseminated infections.


Liver function tests showed alanine aminotransferase 3330 U/L, aspartate aminotransferase 3250 U/L, and bilirubin 21 mg/dL.


Hormone replacement therapy and late-life mania.


Anticoagulant therapy is appropriate for embolic cerebral infarction due to valvular heart disease or cardiac dysrhythmia, as well as for stroke-in-evolution.


An association of granulocytopenia, eosinophilia, skin reaction and hepatitis during propylthiouracil (PTU) therapy for thyrotoxicosis in a 47 year old black female is reported.


While an elevated incidence of lung cancer has been observed in patients with RA or psoriasis, there has been no report of psoriatic arthritis associated with lung cancer.


Two boys were treated with methylprednisolone due to acute exacerbations of Crohn disease.


Although controlled clinical trial data support use of clozapine in treatment-refractory schizophrenia, some patients cannot tolerate this agent or it may increase the risk of physical problems for some patients.


We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).


Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.


As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.


The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.


Naproxen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) whose side effects include tinnitus and transient hearing loss.


Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.


Two young male patients with severe erythrodermic psoriasis and pustular episodes have both been successfully treated with a combination of methotrexate and etretinate for a period of 21/2 years.


Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.


At follow-up, none of the residual lines were associated with thrombus formation, and none showed any evidence of migration.


The definitive role of antiviral therapy is yet to be clarified.


Case report: mannitol nephrotoxicity syndrome: role of hemodialysis and postulate of mechanisms.


The patient was enrolled in a weight-loss clinic, and his diabetes medications were adjusted.Subsequently, olanzapine was discontinued because of weight gain and uncontrolled diabetes.


Drug related crisis in myasthenia gravis.


This case study highlights the different pharmacological agents for treating tachyarrhythmias in a patient with WPW syndrome.


A typical case of dextran-40 associated acute renal failure is presented.


After two weeks of drug treatment, the patient exhibited symptoms similar to those seen in the manic phase of bipolar affective disorder.


2) To perform a review of the published cases of visceral leishmaniasis and anti-TNF-alpha therapy, and cases of coexisting leishmaniasis and macrophagic activation syndrome by search in PubMed (period 1991-2008).


This case report illustrates how pharmacodynamic properties of drugs can complicate the treatment of neurologic disorders.


Vital signs, blood chemistries and a head CT scan were normal.


Prominent positive U waves appearing with high-dose intravenous phenylephrine.


The cumulative dose of prostaglandin E1 was higher in the neonates with antral hyperplasia (2982 +/- 1392 micrograms per kilogram of body weight) than in the normal neonates (279 +/- 270 micrograms per kilogram, P less than 0.001) or the neonates with signs of gastric obstruction (528 +/- 306 micrograms per kilogram, P less than 0.01).


METHOD: The authors present a three-case series in which risperidone was used to treat delusions of infestation.


We describe a 16-year-old girl with metastatic hepatocellular carcinoma who experienced cesium-induced QT-interval prolongation after the start of a cesium chloride-based alternative treatment regimen.


A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.


Mycotic aneurysm of the suprarenal abdominal aorta.


This is the first report of the characteristic phenotypes of the teeth and craniofacial morphology of a patient with leprechaunism treated with IGF-I.


CASE REPORT: We report a case of acute severe hepatitis resulting from erlotinib monotherapy in a patient with locally advanced pancreatic cancer.


This report highlights the fact that using amantadine and pramipexole may be fatal in patients with uremia even undergoing hemodialysis.


Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.


Two patients required emergent surgical procedures.


Methylphenidate (Ritalin)-associated cataract and glaucoma.


Radiological imaging revealed diffuse cortical necrosis.


Ten-17 days after receiving chemotherapy, five patients (4 males and 1 female) with acute lymphoblastic leukemia developed incapacitating myalgias in neck, thighs and arms.


This case demonstrates the potential adverse effects of exogenous estrogen therapy, which are strain-specific in the rat.


Autopsy revealed scarring contraction and dilatation of the trachea and bronchi, acquired bronchiectasis, lobular pneumonia, bleeding, hyperaemia and oedema of the lungs.


In two patients, adenosine precipitated acceleration of ventricular response, in one case necessitating emergent cardioversion.


Administration of a large nesiritide bolus dose in a pediatric patient: case report and review of nesiritide use in pediatrics.


Specifically, the data from our American series are insufficient to evaluate the hypothesis that the M694V/M694V genotype confers a more severe phenotype, or increases the risk of amyloidosis; but both our data and the recent literature (160) indicate that amyloidosis can occur in FMF patients with only 1 copy, or no copies, of the M694V mutation.


The child did not require dialysis therapy.


In such situations, clinicians may want to consider prescribing a different antipsychotic or adding another antipsychotic and decreasing the dosage of clozapine.


All patients received prednisolone and azathioprine during the incubation period.


As a child, he had suffered a traumatic injury to his liver requiring the surgical repair of a laceration.


A 40-year-old man who developed acute myelomonoblastic leukemia (M4) after 7 years of treatment for multiple myeloma with the alkylating agent melphalan and steroids is presented.


METHODS: Case report.


CONCLUSIONS: Clinicians should be aware of a risk of serotonin syndrome with serious extrapyramidal reactions in patients receiving sertraline or venlafaxine when metoclopramide is coadministered even in a single, conventional dose.


Rapid heart rates with QRS complexes that are different from the sinus complexes are likely to be ventricular tachycardia.


However, both the exacerbation of inflammatory bowel disease and de novo inflammatory bowel disease after orthotopic liver transplant (despite sufficient allograft immunosuppressive therapy) have been described.


Multiple retinal infiltrates, placoid subretinal lesions, and ground-glass opacity of the retina with hyperemic optic discs were observed in both patients.


Delayed-onset multifocal polymicrobial keratitis after laser in situ keratomileusis.


A woman, aged 39 years, presented with a localized, painful, pustular eruption of the neck, scalp, and finger of five years' duration.


Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.


Renal biopsy showed acute interstitial nephritis with eosinophilic cells.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Chromosomal analysis showed some abnormalities.


Procarbazine is a chemotherapy methylating agent that has been used in combination with other drugs, perhaps most successfully in the treatment of Hodgkin's disease.


Interventional pain physicians have considerable interest in identifying techniques which avoid these complications.


After 2 months, she developed a severe depressive syndrome which lead to suicidal ideation.


Our case report highlights the need to remain alert for unusual manifestations of syphilis in immunosuppressed patients.


The association of phenothiazine overdose and respiratory distress syndrome merits consideration.


Bisphosphonates, cancer, and osteonecrosis--a single practice experience.


When she came to the emergency room her sodium concentration was 127 mmol/L.


BACKGROUND: Cytomegalovirus (CMV) associated with thrombotic microangiopathy (TMA) in transplant patients has not been extensively described.


It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.


However, its specific role in our patient remains uncertain.


Adalimumab may be effective for the treatment of PPP.


Bronchospasm induced by cardiopulmonary bypass.


Because of their self-limiting nature, the importance of avoiding unnecessary and potentially deleterious antithyroid treatment is emphasised.


It also illustrates the need for continued clinical evaluation of patients with metastatic prostate cancer, even in the face of PSA response.


OBJECTIVE: To report a case of a diffuse papular eruption following treatment of psoriasis with methotrexate injections.


In the case of SSTIs, alternative treatment of these infections should be considered, especially when the bacterial pathogen is unknown.


Frequent blood monitoring in search for any pronounced or sustained drop in red, white or platelet count, even within normal range could serve as a warning sign for myelotoxicity.


The cases described suggest the need for caution when considering tricyclic pharmacotherapy in juveniles with severe depressive disease.


Polymerase chain reaction (PCR) detected CMV-DNA in the aqueous humor in his affected eye, and we started administration of ganciclovir.


A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder.


Two other patients who did not receive prochlorperazine, developed retinal problems which later improved, one after only 15 g of desferrioxamine.


Probable loop diuretic-induced pancreatitis in a sulfonamide-allergic patient.


We report what is to the best of our knowledge the first case of multifocal osteomyelitis following disseminated infection in a patient after haematopoietic stem cell transplantation.


Efficacy and safety of Etanercept, high-dose intravenous gammaglobulin and plasmapheresis combined therapy for lupus diffuse proliferative nephritis complicating pregnancy.


We report three patients, all of whom had preexisting diabetic dyslipidemia, who showed a profound reduction in plasma HDL cholesterol and apolipoprotein AI levels soon after the initiation of rosiglitazone therapy.


Mucopurulent conjunctivitis and exposure keratitis developed in several patients and spontaneous corneal perforation developed in one.


Treatment with naloxone resulted in rapid reversal of signs without sequelae.


With the increased use of neoadjuvant chemotherapy, it is important to recognize previously undescribed mammographic findings secondary to this therapeutic approach.


Trigeminal trophic syndrome with features of oral CMV disease.


He was initially treated with intravenous fluids and opiate analgesia.


Culture was positive for Staphylococcus haemolyticus.


In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.


CASE REPORT: A 64-year-old man was evaluated for chronic low-back pain after multiple spine surgeries.


During that time,weight issues and diabetes status were not addressed.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


Systemic venous thrombosis after recombinant factor VIIa in the control of bleeding after cardiac surgery.


Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.


Ezetimibe is a lipid-lowering agent that inhibits the intestinal absorption of cholesterol and other related phytosterols.


An unusual case of Lafora body disease.


The most likely cause of such hyponatremic episode is vinblastine.


Nephrotic syndrome associated with interferon-beta-1b therapy for multiple sclerosis.


Leuconostoc bacteremia after liver transplantation: another cause of vancomycin resistant gram-positive infection.


The underlying mechanism as well as the treatment of hypokalaemia and hyperchloraemic metabolic acidosis after ureterosigmoidostomy are briefly discussed.


The first patient, a 9-year-old girl, had severe panuveitis complicated by traction retinal detachment, eventually requiring vitrectomy.


The 5 patients had severe renovascular disease which might thus represent a significant risk factor in the development of captopril-induced acute renal failure.


A less well known phenomenon is paradoxical seizures.


Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.


Rarely, liver synthetic function is sufficiently severe to warrant liver transplantation.


Three patients with life-threatening manifestations of systemic lupus erythematosus (SLE), unresponsive to conventional high-dose corticosteroid and/or immunosuppressive therapy were treated with intravenous polyspecific IgG (IVIG).


Trichiasis associated with prostaglandin analog use.


Patients were assessed weekly during CAP-XRT and q 3 weeks during CAP alone.


The 2 cases were remarkably similar in terms of the offending substance, quantity consumed, and subsequent reaction.


Recombinant Factor VIIa (FVIIa) can be used to reverse coagulopathy in patients on coumadin who sustain a traumatic injury.


Propranolol-related bronchospasm in patients without history of asthma.


Culture of a CT guided needle aspiration revealed Francisella tularensis.


The diagnosis of multiple myeloma was made in two white men, aged 55 and 59 years.


METHODS: A patient who developed dramatic, permanent vision loss after a 9-month course of treatment with ethambutol and isoniazid for pulmonary tuberculosis is presented.


L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.


Management of a large organized intraatrial catheter-tip thrombus in a child with acquired immunodeficiency syndrome using escalating tissue plasminogen activator infusions.


The patient's INR had been stable and within therapeutic range (goal 2.0-3.0) for the previous 3 months with warfarin 27.5 mg/wk, but became subtherapeutic after 10 days of bosentan therapy.


Although it is very rare, careful monitoring and readiness for the occurrence of such a potentially lethal situation with necessary medications may prevent a fatal outcome.


Several days were required for the aPTT to decrease after stopping the argatroban infusion.


Reversible posterior leukoencephalopathy syndrome (RPLS) is a syndrome manifested by headache, nausea, vomiting, seizures, cortical blindness, and visual disturbances.


In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.


The remaining deaths were non-MTX related, but all 5 autopsies showed some degree of cirrhosis.


The pulmonary symptoms recurred after discontinuing corticosteroids, five months after amiodarone was stopped, and were associated with a persistent amiodarone level.


A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.


Subsequent use of pamidronate was associated with milder inflammation in the same eye that eventually resolved with continued monthly infusions, indicating the possibility of immunologic tolerance.


The symptoms returned and worsened over the next 4 days, and she returned to the emergency room stuporous.


CONCLUSION: Psychiatric illness should not rule out the possibility of interferon-based therapy, but it calls for close integration of psychiatric and medical care and individualized decision-making based on the biological and psychosocial circumstances of each case.


After the patient discontinued the use of the glucocorticoid eyedrops, his cushingoid features gradually faded, and his blood pressure and serum glucose levels normalized.


Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.


Fifteen days later, blood tests showed CK 1327 IU/L and myoglobin 324 U/L; therefore, the drug was discontinued.


Actinic prurigo and solar urticaria are uncommon chronic idiopathic photodermatoses in the United Kingdom.


This case illustrates the need for close ECG monitoring during ritodrine treatment when clinical symptoms arise.


Chemotherapy schedules including alkylating agents were administered for 1 year, resulting in subsequent remission of the lymphoma.


There has been no literature which reports a case of interstitial lung disease associated with sorafenib.


BACKGROUND: Hepatitis C (HCV) infection is a major cause of liver disease, cirrhosis, and hepatocellular carcinoma.


Two of our patients developed septic shock and deteriorated whereas one patient improved and recovered completely.


Patients who develop these reactions whilst receiving GSTM can be successfully changed to aurothioglucose.


Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.


Early diagnosis and appropriate treatment with intensive topical corticosteroids is essential to successfully manage this post-crosslinking complication.


Rituximab (chimeric anti-CD20 IgG1 monoclonal antibody) is effective in the treatment of relapsed/refractory low-grade lymphomas of B-cell origin as well as in diffuse large B-cell lymphoma.


However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.


Risk factors include previous episodes, dehydration, agitation, polypharmacy, and the rate and route of neuroleptic administration.


We report 3 cases in whom aspirin was indicated for secondary prophylaxis of myocardial infarction but in whom a remote history of an untoward reaction to it prevented its initial use.


Peritonitis remains a significant cause of morbidity in ESRD patients undergoing continuous ambulatory peritoneal dialysis (CAPD).


The possible role of both chemotherapy and the immunodeficiency associated to angioimmunoblastic lymphadenopathy in the pathogenesis of the leukemia is discussed.


Its major side effect of anaemia limits its use in some patients.


The patient began her prescribed radiation therapy and 5-fluorouracil radio-sensitizing chemotherapy.


This therapeutic strategy resulted in normalization of the elevated EBV-DNA titers and disappearance of the monoclonal B cell populations.


Spectral domain optical coherence tomography and angiographic findings in central serous chorioretinopathy complicated by bilateral nonrhegmatogenous retinal detachment associated with systemic corticosteroids.


A literature search conducted to determine the mechanism behind the antagonism of this overdose showed that promethazine interacts with receptors in the central nervous system.


A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.


Delayed pancreatic pseudocyst formations.


Central serous chorioretinopathy developed in 2 cases of retrobulbar neuritis during systemic treatment with corticosteroids.


Patients should be informed about the risk of osteonecrosis when taking dexamethasone as an antiemetic drug.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


CASE SUMMARY: A 21-year-old African American male with schizophrenia came to our medical intensive care unit from the crisis intervention unit (CIU).


One other case of tocolysis-induced vulvar edema has been reported, as have five cases of postpartum vulvar edema, associated with an 80% maternal mortality rate.


The tacalcitol treatment was terminated, seven days later, the serum calcium level had returned to the reference range without any specific treatment.


Therefore, patients on long-term therapy with atypical antipsychotic drugs should be screened periodically for TD.


The latter dialysate was prepared by adding sodium phosphate salts to the "base concentrate" of a dual-concentrate, bicarbonate-based dialysate delivery system.


We report a 16-year-old male who developed nephrotic syndrome related to membranous glomerulopathy with clinical and serological evidence of systemic lupus erythematosus after treatment with griseofulvin.


Recently, the use of octreotide has been described as an alternative treatment in these patients.


Heparin sodium is routinely used in the prophylaxis against deep venous thrombosis in medical and surgical patients.


Eosinophil infiltration is a characteristic feature of nasal polyps associated with AIA.


Based on the clinical status of the patient, it was suspected that several conditions contributed to the abnormal hypersensitivity to warfarin.


Venlafaxine-induced urinary incontinence resolved after switching to sertraline.


The degree of clinical recovery related to maximal disability.


Acute septic arthritis in chronic osteonecrosis of the hip.


He received the full course chemotherapy but without a significant regression.


Three of the four patients also had bilateral ptosis.


Rechallenge resulted in the same drug rash.


Infiltrates, hemorrhages and macular edema present preoperatively dissolved over a period of six months.


Cardial and respiratory function was compromised and intubation was necessary.


During her hospital stay, her sodium level and serum osmolality increased and her urine osmolality decreased, whereas her lithium levels remained within normal limits.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.


After bilateral implantation of an angle-supported anterior chamber intraocular lens (AC IOL) in an allergic patient, the haptic tips were exposed through the limbus in the left eye.


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.


Prolongation of the QT interval and ventricular tachyarrhymias have been described in patients on amiodarone therapy.


Patients who present to the Emergency Department after ingestion of excessive amounts of suflonylurea medications often have hypoglycemia refractory to dextrose administration.


We describe a patient with a liver abscess due to Entamoeba histolytica, in whom metronidazole therapy (total dose, 21 g over 14 days) was complicated by reversible deafness, tinnitus, and ataxia and who relapsed 5 months later with a splenic abscess.


Endovascular treatment of renal artery thrombosis caused by umbilical artery catheterization.


CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.


We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.


In this case of CPM, blindness was encountered and was thought to be "hysterical." The blindness went away after four months.


As an insoluble steroid aerosol, beclomethasone diproprionate was recently made available in the United States.


Power spectrum analysis studies revealed that heart rate had significantly improved and that power spectrum cardiovascular parameters had returned to normal.


The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.


Recognition of amifostine as the cause of this adverse event may prevent the cost and inconvenience of a hospital admission.


We report here the case of a 10-year-old male child with primary steroid-resistant nephrotic syndrome who was non-responsive to steroids and cyclophosphamide.


Merkel cell carcinoma after liver transplantation: a case report.


We discuss a variety of bronchopulmonary complications of IBD and their association with sulfasalazine.


All of the studies were carried out at the University of Pittsburgh Medical Center, Department of Pathology, Neuropathology Division.


Published data on the use of vitamin D for prophylaxis or treatment of any form of osteoporosis fail to document benefits superior to those of calcium alone or calcium with estrogens and fluoride.


After discontinuation of the drug, plasmapheresis and steroid therapy led to a sustained remission.


Nicotinic acid-induced fulminant hepatic failure.


Additional typical findings were the high excretion of adipic acid, suberic acid, and 4-octen-1,8-dicarboxylic acid demonstrating the enhanced capacity of omega-oxidation in fatty acid oxidation.


Switching patients from olanzapine SOT to olanzapine ODT treatment resulted in significant weight loss that was maintained during 12 months in both case reports.


Cardiac glycosides are thought to prevent doxorubicin cardiomyopathy by competitively inhibiting doxorubicin at its receptor sites, but ouabain has a much shorter half life than doxorubicin and its metabolites and so is less effective than digoxin.


Screening for CMV infection in pregnant women receiving immunosuppressive drugs is recommended.


The aetiology in this case is uncertain but it may have resulted from treatment with L-asparaginase or vincristine.


The other patient had no hematoma and his course was dominated by esophageal rupture.


The knee pain and swelling responded promptly to the institution of empirical broad-spectrum antibiotics.


Management included successful treatment with a prolonged course of antibiotics, including ciprofloxacin, neurosurgical drainage and long-term immunoglobulin supplements.


To the best of our knowledge, this is the first report of an association between sunitinib and gynaecomastia.


Primary cutaneous T-cell lymphoma following organ transplantation in a 16-year-old boy.


It also appears to be effective in other conditions such as psoriasis and ankylosing spondylitis.


As physicians begin to treat chronic hepatitis C more often and more aggressively, this potential problem with occur more frequently.


The patient' condition improved after rapid tapering of her epoprostenol and administration of corticosteroids.


The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.


The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.


A case of congestive heart failure in a child with Wilms' tumor treated Adriamycin is presented and discussed.


RESULTS: To date, 13 patients with chronic hepatitis B infection treated with TNF-alpha inhibitors have been reported: 11 with infliximab and 2 with etanercept.


He presented symptoms of hemiparesis 3 days after the operation.


Microangiopathic cytokines released in response to the GVHD and infection may damage the intima of microvessels that were previously injured by the two BMT.


Serotonin syndrome in the perioperative period.


Eight patients developed a total of 12 episodes of sudden, massive vitritis.


Its aetiology is variable and it remains difficult to treat.


Hyperinfection, an augmentation of the normal skin-lung-intestine life cycle, occurs in roughly two-thirds of infected transplant recipients, with dissemination in the remainder.


OBJECTIVE: To report a case of ciprofloxacin-induced psychosis and to discuss occurrence rates, risk factors, possible etiologies, preventive measures, and treatment courses for this adverse reaction.


All nine eyes had recurrence of the membranes after treatment terminated and required a maintenance regimen of corticosteroid eyedrops.


We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.


No adverse reaction was observed from the intra-articular injections.


Full recovery to pre-episode status of a quiet eye with clear vitreous was seen in all patients.


Seizures were controlled by the anticonvulsive agent Dilantin (Pfizer, Khet Klongtoey, Bangkok) and she returned home without any permanent neurologic deficits.


We observed 3 diabetic patients with intolerable dizziness followed by nausea and vomiting immediately after an initial administration of the alpha-glucosidase inhibitor, voglibose.


Similar to reports in patients receiving gefitinib, those with pathologic findings of UIP on resected lung specimens or known pulmonary fibrosis may be at particular risk for erlotinib pulmonary toxicity.


Similarities to dinitrochlorobenzene (DNCB) are pointed out.


CONCLUSIONS: Mecamylamine at 2.5-6.25 mgm/day has no significant peripheral parasympathetic activity and may be safely taken long term (up to 550 days in this study).


We report two cases of Methicillin-resistant Staphylococcus aureus (MRSA) prosthetic hip infections successfully treated with a long course of linezolid.


In deciding if tamoxifen therapy is warranted, all potentially life-threatening adverse events associated with tamoxifen should be considered, including endometrial adenocarcinoma or uterine sarcoma.


Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.


Accidental ingestion and aspiration of hydrocarbons in children are common.


A higher frequency than expected of HLA A 11 in three patients and B 15 in five patients was seen.


The patient was given 14 mg of etomidate and 100 mg of succinylcholine intravenously.


Progressive interstitial lung disease from prolonged methotrexate therapy.


Optic neuropathy developed in a patient with rheumatoid arthritis who had been receiving D-penicillamine for about 1 year.


Coexistence of chronic myelogenous leukemia and chronic lymphocytic leukemia.


A careful and complete medication history can help avoid unnecessary discontinuation of clinically important medications and inadvertent rechallenge with the causative agent.


PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.


After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.


Embolization of a fragmented thrombus or/and attenuation of the lytic state leading to fresh embolization is/are the possible mechanism(s).


We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.


PURPOSE: Utilization of lead-contaminated opium may lead to severe motor neuron impairment and quadriplegia.


Patients at increased risk could be identified.


In two cases, death was believed to be a direct consequence of HUS.


Sulfasalazine has been associated with bronchopulmonary complications of inflammatory bowel disease (IBD) in adults.


An almost total breast reduction was performed; 5 kg of right breast tissue and 7 kg of left breast tissue were excised.


ILP is an effective treatment in recurrence situations or where resection threatens loss of function; it, however, requires administration in specialized centers, progress in standardization and close monitoring to avoid locoregional toxicity, the mechanisms of which merit further investigation.


An objective causality assessment revealed that the interaction was probable.


As in our patient's case, curative treatment for LDE requires discontinuation of the drug.


Systemic administration of corticosteroids was only transiently beneficial in reducing the increased airway resistance.


Her autoantibodies except fluorescent anti-nuclear antibodies were negative.


On April 2, escitalopram was started.


One patient had severe temporary weakness after an ampicillin sodium challenge.


In four patients the levels were > or = 18 times the upper limit of normal.


Three weeks after traveling to Arizona, a 13-month-old, female Labrador retriever developed draining tracts in the right hind limb.


CD4 T-lymphocyte depletion, myelosuppression, and subsequent severe infections are the major side effects of fludarabine phosphate therapy.


We report the case of a 21-year-old female patient with dapsone hypersensitivity syndrome.


Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.


Cytomegalovirus retinitis treated with ganciclovir in a renal transplant recipient.


We report the case of an 11-month-old female infant with a depressed level of consciousness after ingestion of ibuprofen whose mental status markedly improved with administration of naloxone.


We describe a case of delayed onset HIT with resulting massive pulmonary embolism postcardiac surgery that was successfully managed with lepirudin.


However, 50 days after the second UCBT, the patient presented with high fever and developed pneumonia despite antibiotic and antifungal treatments.


Large dose of methylphenidate may cause cataract and glaucoma.


AML/MDS occurred in 3/1374 CLL patients seen at a single institution between 1972 and 1992.


A leukocytoclastic vasculitis was found in both the acute phase and in the amputated fingertips.


An adverse drug reaction (ADR) induced by fluoxetine was suspected and fluoxetine treatment was discontinued.


Stevens-Johnson syndrome (SJS) is a mucocutaneous disease that can be lethal.


It allows safe administration of a different platinum agent in patients who seem to benefit from platinum-based therapy.


The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.


Polymorphic ventricular tachycardia (PVT) is a form of ventricular tachycardia characterized by QRS complexes that seem to change direction during the tachycardia.


Myoglobinuria in boys with Duchenne muscular dystrophy on corticosteroid therapy.


The available data suggest that there is a possibility of risk of major malformations with the anticonvulsants.


Improvement in cholestasis associated with total parenteral nutrition after treatment with an antibody against tumour necrosis factor alpha.


Itraconazole is a widely prescribed triazole antifungal drug, often given for long periods.


Estrogen therapy in a male patient with chronic hepatitis C and irradiation-induced testicular dysfunction.


Acyclovir-induced neurotoxicity: concentration-side effect relationship in acyclovir overdose.


PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.


Praziquantel was ineffective and hazardous, causing some known and some previously unreported responses and reactions.


Portal vein thrombosis responded to thrombolytic infusion into the superior mesenteric artery.


The most common findings are fever, malaise, headache, and exacerbation of cutaneous lesions.


Within hours of the intravenous thiamine, her hypotension resolved.


We confirmed varicella zoster virus using a direct fluorescent antibody test.


Six patients with chronically recurrent oculogyric crises (OGC) are reported.


Severe hyperphosphatemia associated with tumor lysis in a patient with T-cell leukemia.


He had a convex facial profile with a remarkably steep mandibular plane angle and large gonial angle.


Blocking cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) has recently been proposed as a strategy to enhance cell-mediated immune responses to cancer, and clinical trials have demonstrated that anti-CTLA-4 therapy can produce durable outcomes with different response patterns than cytotoxic chemotherapy.


Altered drug pharmacokinetics should be considered as an important metabolic consequence of subtotal gastrectomy.


The infant was monitored by imaging studies followed by ultrasonography.


No viruses (including cytomegalovirus, Epstein-Barr virus, human herpes-virus-6, parvovirus B19, and adenovirus B11) were detected in serum or urine by polymerase chain reaction amplification.


A 3-year-old boy developed alopecia areata (AA) universalis in the convalescent status of phenobarbital-induced AHS, compatible to the evidences of increased lymphocyte proliferation and increased dead cells percentages while his peripheral blood mononuclear cells were incubated with phenobarbital.


Clinical and histological findings were suggestive of pulmonary veno-occlusive disease.


Cutaneous warts, commonly seen in children and the immunosuppressed are socially distressing and are often resistant to traditional treatments.


Two cases were associated with the development of acute renal failure, whereas the third patient had pre-existing renal impairment.


Blood for varicella-zoster virus (VZV) DNA polymerase chain reaction was positive.


A 54-year-old woman had seizures and a focal neurologic deficit associated with hyponatremia induced by a thiazide diuretic.


During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.


Neisseria sicca, previously classified as a "nonpathogenic" organism, has now been recognized as a cause of many infections, including endocarditis and meningitis.


Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.


Stage II lactogenesis was delayed until the tenth postpartum day at which point the patient's breasts became fully engorged.


Pedunculopontine nucleus stimulation induces monocular oscillopsia.


Calcipotriol (Daivonex R; Leo Pharmaceuticals, Zurich, Switzerland) may cause irritation of the skin, whereas allergic reactions are less common.


We report a rare case in which triamcinolone acetonide particles gathered on posterior lens capsule after injection of intravitreal triamcinolone acetonide.


Conversion of ischemic to hemorrhagic infarction by anticoagulant administration.


This case demonstrates that a symptomatic HBV infection can occur in an immunocompromised patient who had originally been anti-HBs-positive.


After the second HSCT at the age of 6.7 years, the child received cyclosporine (target trough whole blood cyclosporine concentration range 150-200 microg/L), starting on day -3, and mycophenolate mofetil for aGVHD prophylaxis.


However, adrenal suppression has only rarely been documented.


Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurrent disease within a year.


After forty-eight hours, he developed jaundice and transaminasemia, which subsided by the eighth day.


Rituximab is a chimeric, anti-CD20 monoclonal antibody initially approved for relapsed, refractory indolent B-cell non-Hodgkin's lymphoma (NHL), and is being applied in an increasing variety of clinical scenarios.


Post-radiation sarcomas following treatment of central nervous system malignancies is discussed.


RESULT: She presented with severe anaemia (PCV of 0.05), White cell and platelet counts were within normal limits and reticulocyte count of 0.001%.


This is a report of a case of anuric ARF after high-dose mannitol infusion for treatment of narrow-angle glaucoma that readily responded to acute hemodialysis.


A comorbid diagnosis of Parkinson's disease in schizophrenia was confirmed in this way.


The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.


We suggest that colonoscopy and biopsy should always be performed if other causes of diarrhea have been excluded.


We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.


Both patients had relatively low serum concentrations of immunoreactive EPO.


A healthy, young adolescent girl developed primary pneumococcal peritonitis, an infection rarely reported in this age group in North America.


In this phase I study 37 patients received 97 courses of KW-2149 administered as an i.v. bolus injection every 21 days at sequential dose levels: 5, 10, 17, 25, 35, 47, 60, 75, 90 and 100 mg/m2.


The association between heparin and priapism is often recognized; abnormal platelet aggregation could play a role in the pathogenesis of this side effect.


He received neoadjuvant chemotherapy and later underwent a right above the knee amputation without complication.


Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.


Prompt acyclovir therapy can be effective, provided an adequate dose is given.


When the infusion was transiently discontinued, recurrences of polymorphous ventricular tachycardia were noted.


Two weeks after the intervention she developed a symptomatic hypercalcemia of 3.57 mmol/L which was resistant to several measures including lowering the calcium concentration in the dialysate, withdrawing all vitamin D and calcium supplementation and the administration of calcitonin.


RESULTS: Oral administration of the beta-blocker propranolol resulted in clinical and echocardiographic improvement of the left ventricular outflow tract obstruction.


Immunosuppression elicited by the extensive administration of prednisolone was suspected for the initiation of the generalized mite infestation.


Gentamicin-associated acute renal failure.


Hyperbaric oxygen therapy for cerebral palsy: two complications of treatment.


His inhibitor titres ranged from 10 to 3450 Bethesda units (BU).


(1) Before PTX, 13 of these patients were not treated with erythropoietin (EPO) while the remaining 7 patients received EPO therapy.


CONCLUSION: Topical thiotepa appeared to be an effective treatment for recurrent corneal haze following myopic PRK.


A 42 year old male with gram negative pneumonia complicated by deep venous thrombosis was followed throughout his hospital stay and for two weeks following discharge.


Dobutamine 5 micrograms.kg-1.min-1 and sodium nitroprusside 1 microgram.kg-1.min-1 were used to increase cardiac output.


Herpetic tracheobronchitis.


This case agrees with the evidence that cisapride potentiates the release of acetylcholine from postganglionic cholinergic nerves in the human isolated detrusor by activating 5-HT4 receptors, i.e. through the same mechanism responsible for its gastrointestinal prokinetic action.


His AFP was initially 9828 microg/L and rapidly dropped to 5597 microg/L in ten days after oral sorafenib treatment.


The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported.


RESULTS: Patient ranged in age from 25 to 53 years.


The patient's medications before admission included quinidine, isosorbide dinitrate, dipyridamole, aspirin, pilocarpine eyedrops 4%, timolol eyedrops 0.5%, and nitroglycerin ointment and sublingual tablets.


AP-ROP in an infant with minimal oxygen exposure.


The infant's fractional excretion of sodium was very low (0.5%) pointing for a severe vasoconstrictive mechanism involved.


OBJECTIVE: To describe onset of syndrome of inappropriate antidiuretic hormone (SIADH) associated with vinorelbine therapy for advanced breast cancer.


The overall case fatality rate was 72%; those patients with ARDS had a 95% mortality rate, while 50% of those without ARDS survived.


Support ranged from 35.5 to 65.75 hr, and VAD flows ranged from 1.0-5.5 L/min.


Computed tomography guided core needle biopsy diagnosis of pelvic actinomycosis.


Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.


Carbamazepine-related hyponatremia following cardiopulmonary bypass.


BACKGROUND: Rapid graft dysfunction caused by hepatitis C virus (HCV) reinfection, although uncommon, is a disastrous complication in liver transplant patients.


The symptoms of UC disappeared immediately, but he developed skin eruptions and dysesthesia in his lower limbs.


The edema disappeared within 24 hr after stopping the infusion therapy.


Colonoscopy revealed a Dukes Stage B colonic adenocarcinoma.


Potential viral etiologies should therefore be considered in cancer patients with pneumonia receiving non-transplantation chemotherapy-regimens, particularly if steroids are a component of their therapy.


The evidence that 5-azacytidine stimulates the production of Hb F and F cells in baboon and man is reviewed.


Moreover, the etiology of t-AML and mechanism of leukemogenesis are likely to be multifactorial and complex.


First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.


No aggravation of OCD symptoms was noted during mianserin administration.


Effective intravenous cyclosporin therapy in a patient with severe Crohn's disease on parenteral nutrition.


BACKGROUND: Methotrexate (MTX) may induce liver damage, which in some psoriatics will lead to fibrosis or cirrhosis.


Terbutaline, therefore, may represent a useful alternative for chronotropic support in the setting of heart transplantation.


Botulinum toxin type B (BTX-B) has been approved by the Food and Drug Administration for the treatment of cervical dystonia.


Previous studies have demonstrated the interaction of MTX and a variety of non-steroidal, anti-inflammatory drugs (NSAIDs) with various clinical manifestations including acute renal failure, pancytopenia, vomiting, diarrhea, elevated liver transaminases, jaundice, mucosal ulcerations, and pyrexia.


No patients in group 1 had marked bridging fibrosis or cirrhosis, compared with 4 of 10 patients in group 2.


Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension, leading to unconsciousness.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


To characterize the relationship between TPO levels and platelet counts in this setting we serially measured both parameters over the entire treatment period of patients receiving multicycle polychemotherapy.


Hypokalemia after normal doses of neubulized albuterol (salbutamol).


CONCLUSIONS: Recurrence of Acanthamoeba keratitis after penetrating keratoplasty a chaud may occur even several months after the operation and the manifestation may be atypical.


Long-term continuous SMS 201-995 treatment has achieved useful symptomatic improvement in diarrhoea in 4 patients with metastatic VIPomas who had relapsed following previous treatment.


Neostigmine appears to be useful in reversing ileus caused by anticholinergic drug overdose.


This technique has the advantage of being simple, economical and nonallergic.


Two days after administration of Kalimate enema, he had profuse hematochezia, and a sigmoidoscopy showed diffuse colonic mucosal necrosis in the rectum and sigmoid colon.


Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.


Reviewing the literature, another eight cases of acute leukemia after cytotoxic treatment for nonmalignant disease in childhood have been reported.


The condition improved slowly after stopping medication and systemic steroids.


Surgery and anaesthesia were uneventful and she gained good symptomatic relief.


Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.


This drug should be studied further for its effectiveness in the treatment of chronic pain.


Successful treatment of patients with respiratory failure due to fungal infection after allogeneic hematopoietic stem cell transplantation.


Recovery was achieved with lamivudine (100 mg/d) and plasma exchange.


The disease is primarily treated with systemic corticosteroids.


The case is unique in that it is the first reported ingestion of oral pilocarpine tablets and the first dosing error reported for this indication.


METHODS: A 76-year-old woman with microbial keratitis and recurrent endophthalmitis after cataract surgery was referred to a tertiary care center for further management.


Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.


We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).


On further examination, acute extensive hemorrhagic gastritis was also found by gastroscopy.


With o,p'-DDD treatment, serum dehydroepiandrosterone sulfate (DS) and urinary 17-ketosteroid (17-KS) excretion fell rapidly while there was a delay in the fall of free androgens.


Close monitoring of INR is recommended, and warfarin dosage adjustment may be necessary.


The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.


Mechanisms and triggering factors of hypoglycaemia induced by mefloquine and some other anti-malarial quinine analogues are discussed.


As far as we know, this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication.


Intermittent, continuous outpatient dobutamine infusion in the management of congestive heart failure.


Pulmonary hemorrhage is an uncommon feature in the HUS, and seems to appear especially in the HUS associated with MMC therapy.


This use for vancomycin, however, has not been studied in the laboratory to evaluate possible toxicities and side effects.


Mycotic aneurysms of the thoracic aorta: repair with use of endovascular stent-grafts.


The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.


However, positive emission tomographic scanning revealed disease progression.


We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.


Cerebral dysfunction predated the development of minimal diabetic complications and had been apparent for between 1 and 17 years.


METHODS: A 79-year-old woman being treated with imiquimod 5 days per week for a nodular basal cell developed a verrucous plaque over the treatment area after 7 weeks of therapy.


He has elected to have future SBCCs managed with C&C.


METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.


We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.


PURPOSE: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity.


Intradiscal injection of triamcinolone hexacetonide for acute, subacute, and chronic sciatica.


Television set or computer screen is the commonest precipitants.


Kidney biopsy revealed ischemic glomeruli and focal segmental glomerulosclerosis lesion.


A variety of medications have been associated with hypoglycemia, but the list of these medications is expanding.


Two patients with paroxysmal nocturnal hemoglobinuria (PNH) and parvovirus B19 (PVB19) infection are reported.


Generally, patients in treatment with isotretinoin avoid eventual pregnancy during assumption and, after its stopping, fertility and foetal development are normal once circulating isotretinoin levels return to normal.


Fungal infection of implantable cardioverter-defibrillators: case series of five patients managed over 22 years.


This case represents the third example of erythroid aplasia associated with an anti-inflammatory agent and the first instance due to fenoprofen.


If these patients are nonimmune, they would be candidates for varicella-zoster immune globulin on exposure, and for acyclovir therapy should varicella dissemination occur.


The common risk factor of both of these two drug-induced ILDs is idiopathic interstitial pneumonia, but ILD in a patient with radiation fibrosis has not been previously reported.


After 56 months, she was free of disease and treatment-related toxicities.


Its use led to simpler drug regimens, improved compliance and significant reduction in the length, or even need, of admission to hospital.


Fatal eosinophilia myalgia syndrome in a marrow transplant patient attributed to total parenteral nutrition with a solution containing tryptophan.


The patient had Hodgkin's disease and responded to chemotherapy and amphotericin B.


Natamycin 5% and amphotericin 0.1% were started and continued for 8 weeks with resolution of the infiltrate and return of the best corrected visual acuity.


He did not have pneumonia.


It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week sulphasalazine syndrome", a rare, but often fatal, immunoallergic reaction to sulphasalazine.


Signs of ischemia, including mottling of skin and painful extremities, preceded the development of the characteristic electrolyte abnormalities and cardiac arrhythmias.


We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.


Angiotensin-converting enzyme inhibitor fetopathy.


Proctoscopic examination revealed a spotty mucous exudate.


Turner's syndrome and its treatment are discussed.


We concluded that the brief quiescent phase (second biopsy specimen) was characterized by retention of immunoglobulin to produce Russell bodies, and that the active phases of the disease were marked by migration of mast cells into the epithelium and by the presence of eosinophils and basophils in the substantia propria.


Involution of endophytic optic disc hemangioma with a single session of photodynamic treatment.


Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.


The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.


PURPOSE: We report an unusual paradoxical effect of brimonidine.


This case also extends the clinical spectrum of cerebral sinus thrombosis to include recurrent transient ischemic attacks alternating with seizures.


No complications resulting from secondary infection occurred.


Severe bronchospasm during cardiopulmonary bypass (CPB) is an unusual event.


It is also known that fibric acid derivatives (fibrates) have several beneficial actions in addition to their lipid-lowering capacity.


The two cases described in this paper are the only known deaths due to anaphylaxis.


Elevated intraocular pressure was noted on average 28 days after presentation (range, 8-69).


CASE DESCRIPTION: A 24-year-old 732-kg (1,610-lb) pregnant Belgian draft horse mare developed neuropathy and signs of intractable pain following colic surgery.


The diagnostic validity of the case is discussed, and some possible explanations of the favourable response to lithium are mentioned briefly.


Both syndromes are mostly related with drugs.


Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.


Mecamylamine in Tourette's syndrome: a two-year retrospective case study.


A case of pheochromocytoma with renal artery stenosis and post-surgical watery diarrhea.


Peripheral nerve dysfunction is a potentially serious complication of high-dose cytosine arabinoside.


In random trials of id injection, observation under clinical and laboratory conditions showed improvement in 63% (17/27) of the patients treated for 6 months with appropriate doses of di-Lex (III3FucnLc4), and in 72% (31/43) of those treated with an identical protocol for TCA.


Response of a promethazine-induced coma to flumazenil.


Flucloxacillin-induced aplastic anaemia and liver failure.


Three days after receiving intravitreal injection of bevacizumab (1.25 mg in 0.1 ml), he developed acute vision loss and change of consciousness.


The pulmonary toxicity of gold salts is an uncommon cause of life-threatening respiratory failure.


Mucormycosis is a very rare opportunistic mycotic infection of diabetic children.


Endophthalmitis due to exposure of anterior chamber intraocular lens haptic tip.


We report a case of simultaneous brain tuberculomas and scrofuloderma occurring in the same patient.


Rofecoxib, used for dysmenorrhea, caused a herpetiform fixed drug eruption predominantly involving the lips with classic clinical and histological findings in a red-brown lesion on the dorsal hand.


The safety of and indications for combination therapy with methotrexate and etretinate are discussed, and the recent reports in the literature of experience with this combination regimen are considered.


However, these other potential causes of seizure were ruled out.


No side effects or drug interactions were observed.


A complication of transesophageal atrial pacing in an infant with Wolff-Parkinson-White syndrome (WPW) is reported.


A follow-up MRI obtained immediately after his cerebral infarction demonstrated notable decrease in the size of the cysts and more prominent enhancement around the peripheral margins of the cysts and the major vessels in comparison with the initial MRI.


The drug acted through: (a) an already known inappropriate release of ADH, and (b) a hitherto unreported tubular lesion, which impaired the reabsorption of sodium and other coupled solutes.


The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.


The technique of serum free level measurement and illustrative examples of specific cases are provided to document the usefulness of this invaluable laboratory test.


The cough is considered to be a class-related adverse effect with cross-reactions between ACE inhibitors routinely reported.


Intraocular pressure may not always return to normal upon cessation of the drug.


Due to discomfort, diplopia and lagophthalmos, the haematoma necessitated suspension of warfarin therapy and a surgical evacuation.


Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.


On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.


This case report confirms highly efficient inhibition of alcohol dehydrogenase by fomepizole, as well as demonstrate the safety of fomepizole in a patient already exhibiting end-organ retinal toxicity.


Respiratory symptoms disappeared within a mean of 60 h (48-96 h) of treatment.


A 15-year-old boy developed nephrotic syndrome and acute renal failure 4 years after allogenic bone marrow transplantation (BMT) for lymphoid crisis of chronic myelocytic leukemia.


Massive gastrointestinal hemorrhage in an immunosuppressed man due to gastric Kaposi's sarcoma.


In the following months, the clinical picture stabilized.


Report of two cases.


The former is thought to be related to central nervous system dopaminergic hyperactivity, while the latter is known to be related to dopamine deficiency.


Copaxone suppresses the production of tumor necrosis factor (TNF)-alpha, a key mediator of inflammation in MS as well as in other pathologies, such as colitis of interstitial bowel disease (IBD).


In: Camus P, Rosenow E, editors.


The patient underwent immediate and delayed hypersensitivity tests.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


CONCLUSIONS: This case report is part of a new and growing body of literature that demonstrates the potential risk of transforaminal injection.


Drug withdrawal and cortisone administration led to resolution of the disease.


When measured, the serum lithium level had increased 4-fold during acyclovir therapy.


Second, we report a case of neutropenia, which proved to be fatal in a schizophrenia patient receiving olanzapine and thiazide.


OBJECTIVE: To report a case of spontaneous hemothorax following anticoagulation with low-molecular-weight heparin (LMWH) for the management of suspected pulmonary embolism.


Steroid hormone deprivation potentially contributed to neovascularization and bowel involvement.


Nurses can be influential in monitoring, assessing, and preventing aluminum overload.


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Using a computer-based algebraic approach, methods for modeling this uncertainty have been formulated.


Thalidomide induces immunomodulator, anti-inflammatory, and anti-angiogenic effects, and may be considered as the elective treatment of this rare variety of erythema multiforme.


Rhabdomyolysis developed with acute renal failure from the probable interaction between these drugs.


A case is presented in which amiodarone was administered to suppress paroxysmal atrial fibrillation in a patient with an idiopathic cardiomyopathy.


The optic neuropathy subsided only when both drugs were discontinued, suggesting an additive toxic effect.


Delayed recognition of intrathecal methotrexate overdose.


CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.


High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer.


The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.


METHODS AND RESULTS: patch testing was performed with captopril, other ACE (enalapril, lisinopril ramipril), and European standard series.


Intraventricular nafcillin-induced seizures in a neonate.


Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.


Presently, treatment of acute ibuprofen intoxication with complications requires supportive therapy until the symptoms resolve over 24 to 48 hours.


This was followed by eight 99 microsecond pulses at an amplitude of 1.3 kV/cm administered directly to the tumors 5 to 15 minutes after the bleomycin was completely infused.


Similar precursor stages, usually not recognised by clinical laboratory tests and consisting of areas of hyperplasia of hepatocytes and sinusoidal cells and sinusoidal dilatation, lead potentially to hepatic adenoma, carcinoma, peliosis, and angiosarcoma.


Although treatment for this syndrome remains controversial and relies heavily on anecdotal evidence, the progression of hepatic injury may be prevented by the addition of N-AC.


Clozapine induced polyserositis.


Data are presented to show a significant absorption of lidocaine through diseased skin when lidocaine cream is used as a local anesthetic.


A 59-year-old white man developed keratoacanthoma of the nose immediately following one course of MOPP polychemotherapy for clinical state IV B mixed cellularity Hodgkin's disease.


CONCLUSIONS: DWI findings in this cohort seem to reflect cytotoxic edema within cerebral white matter suggesting a reversible metabolic derangement, rather than ischemia, as the basis for this syndrome.


Lack of recognition that the lungs too may be a site of spontaneous hemorrhage during thrombolytic therapy may lead to a considerable diagnostic and therapeutic delay.


Isoniazid and vitamin B6 were co-administered with adalimumab.


In addition, a subjective improvement in quality of life and restoration of functioning including a decrease in missed workdays was noted.


As with steroids given by other routes, raised intraocular pressure and cataract may occur.


A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.


Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.


It is characterized as a long-acting prostacyclin analog that can be delivered by intravenous or subcutaneous continuous infusions.


Bone marrow aspirations showed hypocellular-normocellular bone marrow, 98% of plasma cells.


METHODS: We report the clinical outcome of a case of TiACG that was associated with an extreme intraocular pressure elevation of >60 mm Hg that was treated with the combination of systemic mannitol and methylprednisolone.


Stent fracture is uncommon but may have consequences including restenosis.


A case of heterotopic pregnancy, an unusual condition in itself, complicated by pulmonary embolus is presented.


Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.


Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.


Long-term follow-up demonstrated complete flap salvage with no soft tissue loss.


These observations are consistent with the hypothesis that intrarenal regulatory mechanisms contribute to changes in renal function due to amphotericin B therapy.


We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin.


This process was not reversed by lamivudine therapy, hemodialysis, and the use of a Molecular Adsorbent Recirculating System.


Long-term steroid therapy has many well documented complications.


Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.


The reports of this tragic event in the media horrified a mother in another province.


In cases of chronic corneal disturbance, we recommend the elimination of phosphate-buffered medications to prevent corneal calcification.


The clinical course was favorable and the patient achieved full hepatic recovery 3 months after the hepatic failure was detected.


Two patients are presented illustrating some differences between enteral and parenteral feedings in children receiving intensive chemotherapy.


There are major side effects of anastrozole including decrease in both lumbar spine and total hip bone mineral density, increase in the incidence of all bone fractures (especially fractures of spine, hip and wrist), joint disorders and increase in the cholesterol level.


All 8 patients survived and had their hemorrhage or coagulopathy controlled within 4 hours after transfusion of the last dose of rFVIIa.


The literature describing occurrence of DSP on immunosuppression is reviewed and possible pathogenetic mechanisms are discussed.


Vincristine overdose (7.5 mg/m2) was accidentally administered to 3 children with acute lymphoblastic leukemia.


We report five cases of restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) that were probably associated with olanzapine.


Neutrophilic eccrine hidradenitis (NEH) is an unusual self-limited skin disorder characterized by an inflammatory cell infiltrate in the deep dermis involving the eccrine sweat glands, commonly presenting as painful cutaneous nodules.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


Dermatitis herpetiformis is associated with a gluten-sensitive enteropathy in >85% of cases.


After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.


Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.


Adrenaline dacryolith: detection by ultrasound examination of the nasolacrimal duct.


SRL was changed to mycophenolate mofetil, which was followed by quick normalization of serum aminotransferase levels.


The second patient underwent peritoneal dialysis and also had significant problems with hypertension.


The treatment course is divided into five treatment periods, each with accompanying commentary.


The human clinical use of 1% lindane formulations has become somewhat controversial during the past five years.


BOOP is considered as a nonspecific response to many types of lung injury, including drugs, radiation, an underlying hematologic malignant neoplasm, autoimmune diseases, bacterial or virus infection, or an underlying lung disease, or occurs idiopathically.


The optimal diagnostic and therapeutic approach to this entity has not yet been clearly defined.


She died and autopsy revealed extensive hemorrhagic myocardial infarction and a free-wall rupture.


All three achieved complete remission, although one patient relapsed.


Carmustine is the preferred nitrosourea compound for topical therapy of mycosis fungoides.


Bromides appeared to be approximately as effective as diphenylhydantoin for seizure control in this patient.


We report 4 patients who developed symptoms of myasthenia gravis within 2 weeks of starting treatment with a statin drug.


Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide.


Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.


This case report describes the classic presentation of the syndrome, emphasizing the oral manifestations.


The dose of cefoxitin should be reduced in patients with renal functional impairment.


However, recurrent staphylococcus aureus sepsis developed during CyA therapy.


These groups had similar mean ages (31.5-45.4 years) and gender distributions (50.0-60.7% male), apart from RBD.


The treatment of metastatic colorectal cancer to the liver has been a significant problem for clinicians in the past.


CONCLUSIONS: As the elderly population and the incidence of heart disease increase in the United States, more people will probably be using heart drug therapy.


Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.


Prick tests were negative in both the antineoplastic agents.


Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.


Treatment of refractory BK virus-associated nephropathy with cidofovir.


It can be postulated that increased excitability of anterior horn cells at a certain segment might make a spino-bulbo-spinal reflex manifest at the corresponding segment.


The patient had previously received PKP several times.


We present a pediatric patient who developed cutaneous T-cell lymphoma with mycosis fungoides histology after liver transplantation.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


An adolescent with stunted growth was treated for 6 months with a synthetic anabolic androgen.


On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.


Methemoglobinemia secondary to cleaning solution ingestion.


Eleven consecutive JW adult patients with acute leukaemia, all of whom had been denied care in other institutions, were treated at the European Institute of Oncology (EIO) in Milan, Italy.


Symptoms resolved spontaneously and completely after 48 h.


In most cases the cause is unknown, but a minority of cases has been drug induced.


The intention of this case report is to raise awareness for anyone prescribing ciprofloxacin as treatment for infected diabetic and ischemic ulcers.


We report a case of contact dermatitis due to sodium bisulfite in Tathion eye drops.


The patient had no history of seizures in the past and no gross neurologic deficits.


Pediatric and cardiovascular surgeons recommended open-heart surgery as the safest option for catheter removal to avoid the risk of superior vena cava occlusion, vascular rupture, or embolization.


As the use of stimulant medications has ballooned in the past decade, so too has awareness of the cardiovascular complications of these drugs.


A 61-year-old patient who had been treated with lisinopril in the past without any problems was commenced on ramipril for left ventricular dysfunction.


Some of the clots were firmly adherent, whereas others dislodged easily after being rinsed with saline.


We report on a 6-year-old boy with X-linked adrenoleukodystrophy who developed severe delayed alloimmune hemolytic anemia associated with immune-mediated neutropenia and thrombocytopenia following major ABO incompatible unrelated cord blood transplantation.


Prevalence rates and an evaluation of reported risk factors for osteonecrosis (avascular necrosis) in Crohn's disease.


The clinical presentation and course was consistent with acute tubulointerstitial nephritis due to these agents.


Until recently, actinomycin D (AMD), a cytotoxic antibiotic, was considered to cause little or no liver damage.


We describe a case of prolonged terbinafine-induced cholestatic liver disease.


PATIENTS: Two women, ages 49 and 34 years, with endometrial hyperplasia without squamous metaplasia who were treated with progestin.


In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.


Mianserin 30 mg/day, etizolam 1 mg/day and flunitrazepam 1 mg/day were administered.


A suggestion is made to monitor blood formic acid levels and institute prompt dialysis whenever these exceed 80 mg. per 100 ml. to avert such a catastrophe.


Fresh frozen plasma had no apparent effect on aPTT values.


Cisplatin was substituted and the patient achieved a complete response to therapy without further hypersensitivity.


Cysticercosis, the infestation with the encysted larval stage of Taenia solium, is increasingly recognized as a major problem in most countries in Latin America, Asia, and Africa, involving mainly the central nervous system.


Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.


The disease-modifying drugs he was taking, cyclosporin and methotrexate, were stopped, and the lymphoma resolved spontaneously without the use of chemotherapy.


It can be induced by CSA and is totally reversible when the drug is rapidly withdrawn.


A 68-year-old female patient with advanced ovarian carcinoma collapsed whilst receiving a carboplatin and cyclophosphamide infusion.


Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.


Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment.


Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.


The role of somatostatin analogues in the management of obstructive ileus in advanced cancer is discussed.


The ability of tumor necrosis factor (TNF)-alpha inhibitors to impair pivotal pro-inflammatory host defenses may facilitate the development of disseminated cryptococcosis.


Two cases of therapeutic failure associated with levothyroxine brand interchange.


Hepatotoxic effects in a child receiving valproate and carnitine.


Cerebral Embolism Study Group.


An elderly man with procainamide hydrochloride-induced lupus syndrome had a circulating anticoagulant against factor XI and a biologic false-positive (BFP) test result for syphilis.


Only 3 cases of imatinib-induced tumor lysis syndrome have been reported.


Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.


Discontinuation of chlormadinone acetate resulted in decline of the serum PSA level.


Intrathecal rituximab treatment for pediatric post-transplant lymphoproliferative disorder of the central nervous system.


An 11-day-old infant became lethargic and apneic after a single drop of brimonidine.


It is believed to be the first case of cryptococcal meningitis recorded in a child in Saudi Arabia.


Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.


Docetaxel-induced Meibomian duct inflammation and blockage leading to chalazion formation.


Sulfonamides have been reported to augment the hypoglycemic effects of chlorpropamide, glyburide, and tolbutamide.


We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.


An internal work-up remained negative.


Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.


We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.


By using the preloaded biliary catheter, adequate positioning of the laser fiber was achieved in all patients.


According to current knowledge, avoiding unnecessary resection unless it is inevitable is an acceptable option for the management of eosinophilic jejunitis disease.


He was treated with antibiotics and his fever went down.


London: Hodder Arnold; 2009).


4. More than half of the patients developing ANLL have received chemotherapy alone without radiotherapy.


The adverse effects of oral contraceptives on the structure and function of hepatic tissue are reviewed.


Continuous EEG recordings showed a burst-suppression pattern with bursts containing only generalized spikes accompanying myoclonic activity.


Pathologically only a subpopulation of malignant cells responded to the chemotherapy, demonstrating viability of the majority of the tumor, with cell death only in the subpopulation.


Polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analyses and long PCR were performed to detect CYP2D6 genotype.


HSOS following standard chemotherapy has been reported in patients receiving vincristine, actinomycin D, and cyclophosphamide for the treatment of Wilms tumor and more rarely rhabdomyosarcoma.


Malignant myelosclerosis (acute myelofibrosis): report of two cases following cytotoxic chemotherapy.


Somatostatin analog (octreotide) in management of neonatal postoperative chylothorax: is it safe?


Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug.


The patient recovered from oligoanuria to almost normal renal function, and heart, brain, and musculoskeletal injury was reversible.


BAL demonstrated a significant lymphocytic alveolitis typical for hypersensitivity pneumonitis.


The range of previously administered total CBDCA was 2582-9589 mg, and the CBDCA area under the concentration curve of the first treatment exhibited appropriate intensity (mean, 1.92 +/- 0.10; range, 1.76-2.10) in all patients.


In both cases, liver histology showed hepatocellular damage with inflammatory infiltration and microvesicular steatosis without fibrosis.


To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.


Common ocular findings include comeal micro-deposits and lens opacities.


Radiographic calcification in muscles was not seen.


We report a further case with pathological and endocrine details together with a review of the seven cases previously reported and possible mechanisms.


She was a long-term user of an intra-uterine device (IUD) and, although asymptomatic, had radiological evidence of pelvic infection.


Report of three patients.


Severe clinical bleeding secondary to clotting dysfunction has not been previously reported.


Vapreotide was found to reduce nausea and vomiting considerably, by inhibiting the release and action of gastrointestinal hormones and the secretory and motor functions of stomach and intestines.


Hypervitaminosis D developed in four patients with osteoporosis or osteomalacia.


Chest x-ray and thorax computed tomography revealed bilateral hilar masses and nodular infiltrations in the lung parenchyma.


A repeated low dose of the drug induced hyperkalaemia.


Intra-arterial corticosteroid injection at the wrist can have devastating consequences.


This report describes the utility of monitoring free SDC following Fab administration.


Efficacy of caspofungin addition to trimethoprim-sulfamethoxazole treatment for severe pneumocystis pneumonia in solid organ transplant recipients.


ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.


The findings may indicate the spectral nature of the reaction phenomena in leprosy and emphasize the importance of the clinic-pathological correlation for proper classification.


The histopathologic features of fully developed lesions have been reported; however, early-stage findings have not been previously described, and the histogenesis of this lesion is controversial.


The bleeding resolved on discontinuation of APV.


She may have administered doses as high as 8 mg clonidine.


We report on a patient who developed the clinical findings of pulmonary eosinophilia.


This clinically asymptomatic case of skeletal fluorosis was discovered, as in the 2 previously reported cases, by the examination of bone X-ray (performed as part of the routine work-up for rheumatoid arthritis) which showed evident osteosclerosis.


We report a case of ischemic cholangitis that occurred after transcatheter hepatic arterial chemoembolization (TAE).


Hypertension was not present.


Evaluation of the literature provides substantial evidence for the use of hydrocortisone in prevention of cardiac arrhythmias.


Acute pancreatitis and amiodarone: a case report.


METHODS: We report a case of primary CMV gastritis in a renal transplant recipient.


Brompheniramine and dextromethorphan were 0.40 mg/L and 0.50 mg/L, respectively, in the blood sample and 0.16 mg/kg and 0.57 mg/kg in the liver sample.


The patient responded to atovaquone plus proguanil followed by primaquine.


A primary irritant dermatitis occurred in about one half of the patients and telangiectasia in two.


Moreover, decreased levels of the C4 and C3 complement fractions were documented.


METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.


Three years later, multinodular goiter began to develop, and 5 years after that, the patient became hypothyroid.


Ritonavir is a potent inhibitor of hepatic cytochrome P450, mainly the CYP3A4 isoform.


A 9.5-year-old girl after Fontan procedure for hypoplastic left heart syndrome had recurrent protein-losing enteropathy (PLE) develop 2 months after partial catheter closure of the Fontan fenestration.


CONCLUSION: This case provides support for the practice of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and for the implementation of prophylactic antifungal therapy in culture-positive cases.


Malpractice actions against pediatricians treating patients with arrhythmias have been recurrent in four general areas.


Clinical, histological, direct immunofluorescence and ultrastructural features were consistent with the diagnosis of lichen planus pemphigoides.


This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.


Manifestations of ocular blastomycosis can range from keratitis to panophthalmitis, and it is often difficult to diagnose ocular blastomycosis early.


Report of a case and review of the literature.


Clinicians should be aware of this entity, as Nocardia Asteroides may need more than 5 days of culture to be isolated.


The buried bumper syndrome: the usefulness of retrieval PEG tubes in its management.


Naratriptan 2.5 mg given each morning, with a second tablet allowed for breakthrough headache, at least 4 hours later, demonstrated a remarkable reduction in frequency and intensity of daily headache.


A total of 161 doses of L-AmpB were administered.


Serotonin syndrome caused by interaction between citalopram and fentanyl.


OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).


PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.


Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.


A case of pelvic actinomycosis presenting as cutaneous fistula.


One patient required a tracheotomy.


During the terminal stage, a considerable decrease in the size of the liver was observed.


Clonidine is an antihypertensive agent with central and peripheral alpha-2 adrenergic effects.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


Prosthetic valve endocarditis (PVE) caused by Pseudomonas aeruginosa is a rare but life-threatening complication.


The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.


Mucositis should be added to the list of conditions in which succinylcholine is contraindicated.


Pemphigus herpetiformis, a rare variant of pemphigus, is characterized by erythematous, vesicular, bullous, or papular lesions in a herpetiform pattern, often associated with pruritus.


The use of intrauterine Monsel's solution in severe hemorrhage after evacuation of retained products of conception: a case report.


None of the transfusion-dependent patients benefited.


The use of acyclovir when necessary in renal failure patients is discussed.


We present a case of chronic inflammatory demyelinating polyneuropathy occurring subsequent to influenza vaccination in a 74-year-old gentleman with no previous neurological history.


The medication error was noticed after she had received 2 doses of amphotericin B deoxycholate, and it was then discontinued.


In the other patient, who was admitted with an inferior infarction and underwent PTCA after i.c. lysis, no infarct extension was observed.


Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


Finally, irinotecan therapy was initiated and led to dramatic clinical improvement.


An acute psychotic illness in a young woman was initially thought to be secondary to prolonged and pathological grief.


Postoperative bacteriological cultures were negative, and microscopic analysis confirmed the diagnosis.


All three showed improved motor performance in response to the introduction of corticosteroids.


Hyperuricaemia is commonly encountered in patients with essential hypertension and is considered as a risk factor for morbidity and mortality associated with hypertension.


The transmethylation reaction is essential to DNA synthesis and to the maintenance of the myelin sheath by the methylation of myelin basic protein.


A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.


This case demonstrates the maxim that the correct dose of hypertonic sodium bicarbonate is 'enough'.


The patient was treated with glycyrrhizin, and his EP resolved.


Recurrent erythema multiforme is a rare disorder, clinically characterized by symmetrically distributed, erythematous, and bullous skin and mucous lesions, mainly precipitated by a preceding herpes simplex infection.


OBJECTIVE: To study therapy with indapamide impairing carbohydrate metabolism in essential hypertension patients and achieve earlier prevention, diagnoses and treatment of diabetes induced by indapamide.


The mechanism accounting for this observation is unknown but the rapid improvement following abortion suggests that increased bronchomotor tone predominated inflammatory changes in causing flow limitation.


Thus, tacrolimus-induced HUS is a rare cause of ARF in nephrotic syndrome.


Glatiramer acetate is administered by subcutaneous injection once daily.


The clinical course is usually aggressive.


Failure of blood pressure to increase following erythropoietin therapy in the renoprival status.


Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.


Daptomycin is a new cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment.


Heparin-induced thrombocytopenia is a rare and serious complication of anticoagulation therapy.


Administration of intravenous gammaglobulin (25 g monthly) allowed discontinuation of steroids without further ophthalmic or neurologic disease.


Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy.


These movements were dose-related and completely abated on reducing the dose.


Chromosomes were apparently normal.


In phase I clinical trials, hepatitis weas the dose-limiting toxic effect and a dose of 60-70 mg/m2/day for 5 days was reported as the maximum-tolerated dose.


At that time, the viral load was of 4.84 Log and the CD4 count was more than 250 cells/mm(3).


Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache.


Her systemic therapy was initiated at a time when her tumor burden was possibly relatively low and a good response to the aggressive combination chemotherapy including Daunomycin was obtained.


CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.


In addition, 13 other adults treated for chronic myeloid leukemia with various doses of CCNU were reviewed.


Well-known signs of methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration.


Correlated with the lesions evaluated in computed tomography, right hemiplegia and complete aphasia was observed.


This case emphasizes the importance ot considering neoplastic disease as a potential hazard associated with the use of immunosuppressive drugs.


The first organism is exceptionally rare following laparoscopic cholecystectomy and is presumed to be a result of inadvertent gallstone spillage.


We report the occurrence of a cerebral hemorrhage related to cerebral amyloid angiopathy in a patient who underwent thrombolysis and treatment with heparin for acute myocardial infarction.


BACKGROUND: An infusion of prostaglandin E1 is widely used to maintain patency of the ductus arteriosus in neonates with congenital heart disease.


Persistent ashen-gray maculae 5-7 mm in diameter and freckles developed after prolonged PUVA therapy of psoriasis.


Although haloperidol was discontinued, no further hallucinations or delusions occurred.


In a follow-up of 14 months, acarbose was well tolerated and the frequency of dumping symptoms was remarkably reduced.


Celecoxib, a cyclooxygenase (COX)-2 inhibitor, was administered for pain management and for potential antineoplastic activity.


In our view, GM-CSF should be given as early as possible with enough dosage for promoting early hematological reconstruction.


Medication-induced dystonias in nine patients with dementia.


Retinal artery embolization during carotid angioplasty and carotid artery stenting: case report.