Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis.


There had been one episode of chest discomfort in her past history.


Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


Intravenous thrombolytic therapy has become standard treatment for acute myocardial infarction (AMI).


In a second man the symptoms of prostatism diminished but in the third urinary frequency and nocturia persisted in spite of a reduction in prostatic size, presumably because his symptoms were due to renal insufficiency.


Beginning the second day of therapy, the patient complained of nausea and associated vomiting.


We concluded that HLH, a rare but often fatal condition characterized by excessive activation of lymphocytes and macrophages, is a diagnostic and therapeutic challenge in solid-organ transplanted patients and must be suspected in the presence of fever, blood cytopenia and liver dysfunction.


Tocolysis was initiated with oral ritodrine hydrochloride (15 mg/day) alone.


A 70-yr-old woman presented with a 9 cm left upper outer quadrant breast mass associated with overlying skin redness and a 2.5 cm left axillary mass.


Brain MRI revealed lesions in the thalamus and the brainstem, particularly the tegmentum, and the basis pontis in addition to the basal ganglion lesions.


Acquired internal mammary artery to pulmonary artery fistula following bypass surgery.


Bacterial and fungal contaminants have been identified in marijuana samples and thus are a potential risk factor in the immunocompromised patient using it as an antiemetic.


We report on successful liver transplantation in a patient with CSD who suffered from chronic hepatitis C.


Severe sulfadiazine hypersensitivity in a child with reactivated congenital toxoplasmic chorioretinitis.


The incidence of seizures related to primary brain tumors is 20-80%.


In both cases, the timing and dose of disulfiram was known.


In one case the central serous chorioretinopathy recurred 3 times during 3 separate courses of treatment.


We report a relapsed HIV-related high-grade NHL which was treated successfully with ESHAP chemotherapy followed by high-dose chemotherapy and autologous bone marrow transplantation (ABMT).


Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider.


Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.


Gynaecomastia, however, persisted even after three months of cessation of therapy.


Some patients received antiviral therapy for hepatitis B (specifically lamivudine) before, during, or after TNF-alpha inhibitors were started.


We postulate that an immune-mediated disruption of caveolar function was exacerbated by statin exposure.


CONCLUSION: There is currently no consensus regarding the optimal therapeutic approach to Merkel cell carcinoma.


The patient was successfully treated by discontinuation of cyclosporine and mycophenolate mofetil, initiation of systemic amphotericin B, and aggressive surgical debridement.


We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.


A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.


Thus in spite of the failure to demonstrate a platelet autoantibody, the rapid response to steroids in association with a reduced platelet survival is compatible with an autoimmune platelet destructive process.


He quit smoking after 1 week of therapy and remained smoke free for the next 17 days.


Nat Rev Cancer 2002;2:124-132).


The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.


In two neonates with antral hyperplasia, the cessation of therapy lessened the gastric-outlet obstruction.


The case study reports were linked to and discussed in relation to possible explanatory models for increased olfactory sensitivity.


CONCLUSION: We believe that risperidone is not a substitute for clozapine in treating psychosis in parkinsonian patients and should be used with caution.


At retest visits respectively 18, 19 and 20 years after cessation of hydroxychloroquine, a multifocal electroretinogram was performed in combination with colour vision tests and contrast sensitivity measurements.


Despite prolonged external biliary drainage and systemic amphotericin B therapy, the fungus was not eliminated from her biliary system.


A dose of 100 micrograms/day improved muscle tone, head control, posture, and walking distance; electromyography showed a marked decrease of dystonic muscle activity with fully preserved voluntary muscle activity, and the patient reported substantial reduction of pain.


Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.


The authors report a case of a patient who received alteplase for acute myocardial infarction and developed spontaneous subfascial hematoma without any evidence of direct trauma.


After eyelid reconstruction the patient's visual axis has remained unobstructed, and amblyopia has been thus far averted.


Tuberculosis post-liver transplantation: a rare but complicated disease.


Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol.


Both patients developed granulocytopenia after multi-agent chemotherapy.


Subsequent disease evolution to EM major occurred in all cases (Stevens-Johnsons syndrome developed in 73% of patients).


Isoniazid and ethambutol as a cause of optic neuropathy.


A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis.


Graft versus host-like illness in a child with phenobarbital hypersensitivity.


The patient developed bilateral shoulder pain followed by decreased function of his upper extremities 2 days later.


A case report of Cheyletiella infestation on a Whippet dog in Korea.


Sister chromatid exchanges (SCEs), a sensitive measure of chromosome damage, were counted in peripheral-blood lymphocytes from 10 patients with Behcet's syndrome receiving chlorambucil.


The tissutal typing of the patient showed the presence of Human Leukocyte Antigen (HLA) DRB1*11 gene (corresponding to DR5 antigen).


New lesions gradually spread to the arms and trunk (Fig. 1).


Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.


We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.


The surgical resection and chemotherapy of metastatic osteogenic sarcoma of the right ventricle.


Age at diagnosis was 43 +/- 3 years (range, 37-47).


Symptoms include fever, chills, cough, pleuritic chest pain, dyspnea.


Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.


A study following large patient groups on theophylline and a combination of theophylline and steroids might clarify the risk of ulcer formation in patients being treated with these medications for asthma.


Increasing the olanzapine dosage severely aggravated the symptoms of RLS.


Successful treatment of a colonic ulcer penetrating the urinary bladder caused by the administration of calcium polystyrene sulfonate and sorbitol.


Since epithelial downgrowth involves an actively proliferating intraocular tissue, it is possible that the antimetabolite 5-fluorouracil may inhibit it.


A survey of members of the Retina, Macula, and Vitreous societies and the National Registry of Drug-Induced Ocular Side Effects identified three additional cases.


Anesthetic care of a patient with an intracranial hemorrhage after thrombolytic therapy.


Chronic hepatitis C virus (HCV) infection is associated with several extrahepatic syndromes.


The history of a 4-week-old infant with meningitis and multiple cerebral abscesses caused by Salmonella enteritidis is reported.


We report a case of immune reconstitution syndrome in response to antiretroviral therapy in a HIV-positive patient on antituberculosis therapy for multidrug-resistant tuberculosis.


METHODS: A single patient who developed uveitis while taking clomiphene citrate is described.


A young woman with epilepsy had tonic-clonic seizures during antineoplastic therapy with adriamycin and cisplatin.


Ten months later, he had again pyrexia and suffered from congestive heart failure.


Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.


A 51-year-old-woman presented with chronic eosinophilia, a diffuse interstitial lung pattern on CT and splenomegaly with hypodense lesions.


BACKGROUND: Recombinant activated factor VII (rFVIIa), originally developed for the treatment of life-threatening bleeding in hemophilic patients with inhibitors to factors VIII or IX, has been increasingly used to control hemorrhage unresponsive to conventional treatment, in the absence of a defined coagulopathy or thrombocytopathy.


Spontaneous bacterial peritonitis induced by intraarterial vasopressin therapy.


DISCUSSION: beta-Lactam-induced leukopenia is a rare but well-described adverse drug reaction.


To our knowledge, petit mal status lasting longer than 2-3 days has been documented only once [1].


Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.


the treatment was administered in a two-step process.


Clinical signs of peripheral neuropathy developed 2 weeks and 12 months after the initiation of TNF-alpha antagonists.


The purpose of this review is to highlight the toxicity of chloral hydrate and to review the management of overdoses with chloral hydrate.


Neither had previous evidence of underlying cardiac disease.


We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis.


MANAGEMENT: Thalidomide withdrawal, dexamethasone maintenance therapy, monthly oral courses of combined melphalan and prednisone, salvage therapy with bortezomib.


However, just after dilation, the patient complained of ocular pain and blurred vision on the right, which was subsequently diagnosed as retinal artery embolization.


Hypersensitivity reaction is an unexpected drug adverse effect which sometimes can lead to fatal condition.


Cytomegalovirus retinitis is an opportunistic and vision-threatening disease in immunosuppressed patients.


Nevertheless, the coagulopathy seemed to be most closely associated with the administration of the cephalosporin.


OBJECTIVE: To describe the pathology and the rehabilitation of an uncommon complication of intrathecal drug administration during the oncologic treatment of acute lymphoma.


Much has been learned about heparin-induced disease, but complex issues remain.


Unlike most stent fractures reported that involve stent struts only our case demonstrated circumferential disruption with complete separation of the stent segments.


An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.


Cerebral and ocular toxicity induced by desferrioxamine.


Clinical manifestations and therapy of Lactobacillus endocarditis: report of a case and review of the literature.


In followup, 18 patients reported limb dysfunction ranging from 5-365 days.


A third patient experienced disabling neurotoxicity in the extremity of a prior ulnar nerve and tendon transposition after receiving paclitaxel.


Arteriography demonstrated extensive pruning of the distal arterial tree along with bilateral external iliac artery dissections - a finding that is not often associated with young, normotensive patients with chronic ergot toxicity.


The effect of trimethadione treatment on dissolution of stones was not closely related to the aetiology of the disease, distribution and size of stones, previous history of surgical interventions, or the degree of pancreatic dysfunctions.


The allograft function remained stable.


Different pathologies have been described as caused by henna.


Two patients developed diabetic coma when taking a combination of a thiazide diuretic and propranolol.


Subsequent to diagnosis the patient was heparinised with unfractionated heparin (UFH 300-450 IU/kg/d i.v.).


We report the case of a 77 year old with Staphylococcus lugdunensis endocarditis following cardiac catheterisation via a femoral approach.


A positive dechallenge was reported in 29 cases.


We present in this article the clinical features and autopsy findings of a steroid-dependent subject with asthma who died of acute, disseminated varicella.


CONCLUSIONS: The piloerection observed after the replacement of fluvoxamine with milnacipran in this patient appears to have been due to an increase in the alpha(1)-adrenoceptor occupancy by endogenous norepinephrine induced by milnacipran.


The patient was treated by chemotherapy only, without surgery, which seems to be most appropriate for the early stages of this disease.


Remissions following total body surface treatment varied from two weeks to at least four months.


Two patients with extrapyramidal side effects after the use of fluphenazine decanoate were evaluated by means of IBZM-SPECT.


Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.


Treatment is unsatisfactory, although steroids and plasmapheresis may prolong survival.


Options for avoiding allegations of abandonment are proposed.


DISCUSSION: No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea.


Before the treatment of co-trixomazole, their serum levels of creatinine showed upper limits of normal ranges.


A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody, positive lupus erythematosus (LE) cell preparation, and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy.


One of these patients relapsed after he stopped taking the preparation at his own initiative after 10 weeks.


Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.


The possible mechanisms of photo-onycholysis development by modern atypical antipsychotics, modulating dopamine receptors, are discussed.


Persistent light reactivity from systemic quinine.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


The two children who had severe myelotoxicity achieved the largest AUC values per milligram per square meter of 6MP.


Patients should be informed of the risk of septic arthritis.


PURPOSE: To describe the use of topical thiotepa in the treatment of recurrent haze after photorefractive keratectomy (PRK).


Fatal chickenpox in a patient with nephrotic syndrome.


We report an unusual case of thrombocytopenia associated with neuroleptic malignant syndrome (NMS).


The methimazole was stopped and treatment with subcutaneous granulocyte colony-stimulating factor (G-CSF) was initiated.


Patient 1 is a 59-year-old woman who underwent delayed breast reconstruction with a free TRAM flap and presented with arterial thrombosis 12 days postoperatively.


Two patients did not receive corticosteroids or parenteral nutrition.


Six month follow up showed maintained antiparkinsonian benefit, without need for levodopa treatment and complete absence of dyskinesia.


Coagulation and complete blood count values were within the normal range.


One patient was an 80-year-old woman who was admitted for Staphylococcus aureus knee arthritis after several intraarticular injections of sodium hyaluronate and corticosteroids.


Implantation of a sustained-release ganciclovir device was performed in both eyes when retinitis progressed in spite of aggressive antiviral intravenous treatment.


CONCLUSIONS: Complications concerning a primary perforation of the bladder and instillation of chemotherapeutic drugs can be easily avoided by recognising the perforation intraoperatively.


A review of the medical literature indicates that the optimal treatment for acute beta-blocker toxicity is intravenous glucagon.


It can also be used to treat hematuria through its action on decreasing urinary fibrinolysis.


A patient with ulcerative colitis developed skin pigmentation and diffuse pulmonary shadowing without respiratory symptomatology, while taking sulfasalazine.


Case study: This middle aged Malaysian man presented complaining of painful gums for a few months.


Symptomatic cluster headache related to ocular pathologies have been rarely described.


A 44-year-old man presented to the emergency room with sudden onset of fevers and rigors 7 weeks after renal transplantation.


Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction.


Ectropion secondary to bolus injection of 5-fluorouracil.


The diagnosis can be made after the exclusion of other causes of rheumatoid lung when the patient's poor respiratory status precludes invasive exploration.


Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.


No severe adverse event occurred during clinical trials.


High-dose steroid therapy offers improvement in spinal cord injuries.


Aminoglycosides have been reported to cause tetany by inducing renal wasting of magnesium and secondary hypocalcemia.


Three case reports.


BACKGROUND: Diffuse lamellar keratitis (DLK) is a relatively uncommon complication of the refractive procedure, laser-assisted in situ keratomileusis (LASIK).


CASE REPORT: An East-European prostitute in Amsterdam robbed several victims, after having sedated them with clonidine solution (available as plastic ampoules of eyedrops) added to her victims' drinks.


Osteonecrosis appears to render the hip more susceptible to hematogenously derived bacterial infection.


We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.


We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.


We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.


There was no evidence of another cause of colonic ischaemia.


This study describes the inheritance of a defect in pyrimidine catabolism and its association with drug-induced toxicity in a patient receiving 5-fluorouracil (FUra) as adjuvant chemotherapy for breast carcinoma.


CASE REPORT: A woman of 80 years, on long-term warfarin therapy presented with an acute dissecting thoracic aortic aneurysm; on investigation the only precipitating factor found was an international normalised ratio of 4.8.


Patients whose lesions originated in the skin were in the majority (14 patients).


Atomoxetine has been explored as an alternative treatment as one of the few non-stimulants available to treat ADHD.


Prominent EPS developed soon after initiation of an atypical neuroleptic agent.


Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.


EGFR-targeted therapy and related skin toxicity.


Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.


After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.


This paper describes a possible side effect previously unreported--papilledema not associated with peripheral neuropathy.


There are few reports of salvage chemotherapy for HIV-related non-Hodgkin's lymphoma (NHL).


DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.


We review in clinical detail the fifth case reported from North America, involving a child with extensive central nervous system involvement.


A smear for acid-fast bacilli or a culture was positive in 73% of cases.


This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.


Reye syndrome associated with subclinical varicella zoster virus and influenza A infection.


Because the patient remained bradycardic on postoperative day 11 (HR 64 beats/min; mean 75), terbutaline was titrated to a dosage of 5 mg every 8 hours.


There are isolated case reports of stroke secondary to the use of triptans, however, this is the first case of spinal cord infarction reported following the use of this group of drugs.


We report a patient who developed adult respiratory distress syndrome (ARDS) secondary to Mycobacterium tuberculosis as an immune reconstitution disease.


The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia.


He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.


This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.


He had a history of occupational exposure to asbestos as a construction worker.


Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.


The exogenous origin of the lipid in the BAL fluid was confirmed by gas chromatography/mass spectrometry.


The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks.


With the weekly schedule, new types of toxicity have been described and we report four patients who have developed a severe sensory-motor neuropathy with the chemotherapy which appears to be drug-related.


In both cases the presenting symptoms were indistinguishable from hospital-acquired pre-engraftment diarrhoea, which is commonly caused by Clostridium difficile.


Pirmenol hydrochloride is a new orally effective, long-acting antiarrhythmic agent currently used in patients with supraventricular and ventricular tachyarrhythmias.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.


Both grafts were successful and remained clear.


METHODS: We present a case report on the use of an indium (111) diethylenetriaminepentaacetic acid (DTPA) flow study in the evaluation of a lumbar swelling in a 16-year-old girl with spastic cerebral palsy, treated with continuous intrathecal baclofen (CITB).


A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.


We report a patient who developed acute pancreatitis during amiodarone therapy.


A literature review revealed 83 other reported cases of rifampicin-induced renal insufficiency.


We report six cases of endometrial sarcomas complicating ovarian thecomas, polycystic ovarian disease, or prolonged estrogen therapy.


Topiramate may be a treatment option in CPH.


An increase in tumor volume of 25% was observable 15 days after the beginning of therapy.


The decrease in p(a)CO(2)induced by halothane may be explained by the diminished dead space that results from the drop in peak airway pressure.


In three patients who stopped this medication of their own accord, pancreatic stones re-increased or reappeared about 6 months later.


On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA).


A case of acute cardiomyopathy and pericarditis associated with methylphenidate.


CONCLUSIONS: Influenced by a variety of factors, pathophysiological microvascular changes provoke anterior ischemic neuropathy with sudden painless loss of vision, irreversible in most cases.


She subsequently developed a classic varicella rash, sever back pain, rapidly progressive hepatic failure, pneumonitis, and encephalopathy.


We report on a patient who developed hypersensitivity pneumonitis during treatment with the beta-blocker, celiprolol.


This event rendered a family grief-stricken and numerous health care providers forever changed.


Ultrastructurally the follicular cells contained large residual bodies composed of abundant electron-lucent lipid droplets of variable size.


Traditionally, patients with rheumatoid arthritis (RA) have increased risk of nodal and extranodal lymphoid malignancies such as non-Hodgkin's lymphoma (NHL).


Eighteen patients were transfusion dependent; 10 had refractory anemia (RA), and 10 had refractory anemia with ringed sideroblasts (RARS).


The patients were all women aged 21-55 years.


She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.


We report a typical case of post-transfusion purpura (PTP) due to anti-PlA1 in a 65-year-old woman.


Various features are often seen during the course of the disease.


We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.


Growth hormone deficiency (GHD) related to standard dose chemotherapy has rarely been described.


The vagina was saline-irrigated after realising that the acetic acid had not been diluted.


Normal urinary Na excretion without hypotension or hemoconcentration negated the possibility of dehydration resulting from urinary Na loss.


Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.


Late infection was suspected from his symptoms and laboratory findings, and a wide spectrum antibiotic was administered.


We suspect that a similar immunological pathway played a role in the pathogenesis of AGEP appearing in psoriasis and ulcerative colitis.


A 61-year-old male with a history of severe heparin-induced thrombocytopenia (HIT) type II after aorto-femoral bypass surgery presented to the emergency department within 8 hours of development of substernal chest pain radiating to the left arm.


We report a case of a previously healthy, postmenopausal woman who developed anticonvulsant hypersensitivity syndrome while taking Bellamine S (belladonna alkaloids; ergotamine; phenobarbital) for hot flashes.


Esophagogastroduodenoscopy and colonoscopy were negative for bleeding.


Zolpidem was present at concentrations of 2.91, 1.40, and 2.13 microg/mL in the heart blood, peripheral blood, and urine, respectively.


Historically, coagulation screening has not been routinely recommended after organophosphate intoxications.


BACKGROUND: In the 1940s and '50s the first oral hypoglycaemic agents (the sulphonylureas and metformin) became available.


Meglumine antimoniate, amiodarone and torsades de pointes: a case report.


Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.


In this report, one patient who developed gangrene after bleomycin and vincristine/vinblastine chemotherapy for AIDS-related Kaposi's sarcoma and another HIV-infected patient who exhibited symptoms of severe Raynaud's phenomenon related to the same regimen are presented.


We report the case of a 77-year-old male who developed a florid photosensitive eruption while taking thiazide diuretics for heart failure.


We report a case of a bullous lichenoid eruption due to the intake of captopril.


Premature closure of the ductus arteriosus: variable response among monozygotic twins after in utero exposure to indomethacin.


The manifestations of delirium tremens persisted with titration of a lorazepam infusion in excess of 40 mg/hour.


Ultrasonography revealed hepatic hyperechogenicity.


A case is reported in which a several-fold increase in transaminases and gamma-GT was detected in an elderly male patient with fatty liver.


Treatment is symptomatic.


The mechanism is probably multifactorial.


Terbinafine-induced cholestatic liver disease.


They seemed to involve multiple aetiological factors, such as autoimmune thyroid disease, the toxic and immunomodulatory roles of lithium and perhaps genetic and dietary factors.


Outcomes are compared on the basis of remission, survival time, and treatment-related toxicity.


CT scan and ultrasound before the surgery did not show any tumor.


Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.


A CT scan shows diminution in the size of the tumor.


Chemotherapy is frequently used to treat adenocarcinoma.


On the seventh day of therapy, he experienced fever, with temperatures as high as 38.8 degrees C.


Acquired long QT develops most commonly because of drugs that prolong ventricular repolarization.


This constellation of biochemical abnormalities mimic Type 5 Bartter's syndrome, where there is activating mutation of the calcium sensing receptor in the thick ascending loop of Henle and the distal tubule.


Biopsy and direct immunofluorescence study of the skin showed changes consistent with the diagnosis of lupus erythematosus.


The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.


Hyperammonemia secondary to valproic acid as a cause of lethargy in a postictal patient.


A case of sideroblastic anemia is presented in a patient with a left ventricular assist device drive-line infection who was receiving linezolid, an antibiotic used for serious infections with gram-positive organisms.


Neutropenic colitis during standard dose combination chemotherapy with nedaplatin and irinotecan for testicular cancer.


We report 3 patients with autoimmune hepatitis who either could not tolerate or failed to improve on azathioprine but responded well to 6-mercaptopurine.


Direct biopsy of this mass revealed a large B-cell lymphoma.


There were no complications as a result of naloxone therapy.


There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.


In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.


A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis.


A 23-year-old black woman with a two-month history of seizure disorder was admitted to a hospital with nausea, vomiting, fever, lymphadenopathy, diffuse maculopapular rash, left-upper-quadrant tenderness, and hepatomegaly.


Between 1988 and 1993, 525 adults underwent OLT.


Her symptoms regressed after inhaler steroid treatment.


Therefore, we diagnosed her eruption as contact dermatitis due to sodium bisulfite.


Both are alive without evidence of leukemia.


Sixteen of 33 patients developed significant hyponatremia and hypoosmolality during oral treatment with lorcainide.


Drug induced renal failure is a serious, potentially, fatal illness that is preventable.


It is likely that her inability to excrete absorbed aluminum contributed to her death.


Several also reported improved sleep at night.


Cardiac arrest following use of sumatriptan.


This case is reported in support of the dopamine hypothesis for the etiology of schizophrenia.


We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.


Therefore, physicians and dentists alike must understand how to identify and prevent these adverse effects in order to further improve HIV patient treatments.


Cyclophosphamide pneumonitis.


Additionally, their Global Assessment Scale (GAS) score increased significantly from a mean of 30.8 +/- 4.7 to a mean of 43.1 +/- 8.6 (t = 5.19, df = 14, P = .001).


He relapsed a month later with Enterococcus gallinarum shunt infection, which responded to high-dose ampicillin and gentamicin therapy.


Eighteen hours after chemotherapy she was noted to have hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and acute renal failure.


Twenty-four to seventy-two hours following the switch, all patients developed intractable headache, despite the use of different symptomatic drugs.


It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.


During tacrolimus treatment, there were no further episodes of graft rejection and no incidents of herpes simplex virus infection or reactivation, with the longest follow-up being 4 years.


Following, we performed a double-blind oral challenge test with drugs who results was negative.


The patient described here has had to data 12 years without any oncopathological symptoms.


Best-corrected visual acuity measurements were performed at every visit.


The melanocytes were strongly stimulated at the site of the freckles.


At follow-up examination the patient continued to be asymptomatic, with the radiologic persistence of the infiltrate.


The failure of parenteral copper therapy in Menkes Kinky Hair syndrome.


CASE REPORT: A 64-year-old female patient with metastasized esophageal carcinoma received simultaneous chemoradiotherapy of the upper mediastinum with 50.4 Gy and cisplatin/5-fluorouracil.


Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.


CONCLUSION: We conclude that NIC may be an important treatment option in cases of severe intoxication causing cerebral swelling.


Following IVIG infusion, lupus encephalitis in the first patient quickly resolved and the impressive improvement of the clinical status was associated with a transient increase in C1q-binding activity.


We describe a 28-year-old woman who developed stridor, orofacial swelling, and drooling several hours after a routine dental extraction.


A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.


After an intravenous course with acyclovir, the child made a full recovery with no neurologic sequelae.


We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.


CONCLUSIONS: SD-OCT and AO detected abnormalities that correlate topographically with visual field loss from hydroxychloroquine toxicity as demonstrated by HVF 10-2 and may be useful in the detection of subclinical abnormalities that precede symptoms or objective visual field loss.


Hepatic and peritoneal metastases are the most frequent metastatic lesions in patients with gastrointestinal stromal tumors (GIST), and may result in intra- or extrahepatic cholestasis and altered drug metabolism.


However, clozapine must be used cautiously due to its side effect profile.


One patient died of an arrhythmia that deteriorated into asystole, and 2 patients recovered and underwent coronary angiography.


We reviewed the literature in an attempt to characterize the pattern and predictors of TMP/SMX-induced aseptic meningitis.


Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic (respiratory rate: 4-5 bpm), hypotensive (BP 70/40 mmHg), and responded only partially to command.


Use of fenofibrate in the management of protease inhibitor-associated lipid abnormalities.


The operation was performed by the standard technique (Lower-Shumway) in the first patient and by the bicaval anastomosis technique in the second patient.


Streptococcus pneumoniae was more frequently eradicated in the azithromycin than in the ceftibuten group, whereas gram-negative bacilli were more susceptible to ceftibuten.


Our experience of this case led us to conclude that: patients with pulmonary metastases may develop bilateral and/or recurrent pneumothoraces following chemotherapy; computed tomography scan is essential for defining the cause of SSP; and closed chest tube drainage remains the therapy of choice, while chemical pleurodesis may also be used to prevent recidivant SSP.


Both reactions occurred late in the course of treatment.


Piloerection induced by replacing fluvoxamine with milnacipran.


Interestingly, the use of carboplatin (CBDCA) and VDS in the subsequent treatment course was well tolerated indicating that the SIADH was most likely to have been induced by administration of CDDP.


We present a case of mucormycosis primarily affecting the paranasal sinuses in a 51-year-old man with a kidney allograft.


An early asymptomatic recurrence was observed in three patients 49 to 53 days after the initial diagnosis.


In young children, however, they can also stimulate alpha2receptors in the cardiovascular and central nervous systems, possibly causing cardiovascular, neurological, and respiratory depression.


A 42-y old woman swallowed 60 ml of 50% malathion in a suicide attempt.


Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia.


Clinicians should, therefore, consider AI in patients with spinal cord injury receiving glucocorticoids, a population in whom it may otherwise go undiagnosed and untreated.


The objective of this report is to describe a case of fixed drug eruption that occurred during omeprazole treatment.


OBJECTIVE: This case discusses a rare but devastating complication of transforaminal epidural injection.


In our experience, once established, infections may rapidly progress in patients with RA taking leflunomide, and early cholestyramine washout is strongly recommended.


She was receiving high dose corticosteroids, azathioprine 200mg daily and high dose intravenous immunoglobulin during relapses.


These episodes had some atypical features that will be discussed with regard to the pathophysiological mechanisms leading to NMS.


Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.


Treatment consisted of topical application of 0.1% tacrolimus ointment three times a day.


CONCLUSIONS: X maltophilia is a potential intraocular pathogen in an immunocompetent host.


A 16-year-old girl with refractory AML received unmanipulated BMT from an unrelated donor.


To our knowledge, this is the first report of insulin-induced lipohypertrophy with detailed histological examinations.


Her symptoms soon alleviated and serum lipase level declined.


Because many glaucoma patients are elderly and vision is frequently impaired, overdosing may be the mechanism of side effects in many patients especially the elderly.


Chlorambucil (CHL) was used in combination with prednisolone in the treatment of nine children with frequently relapsing nephrotic syndrome.


In conclusion, a case of prednisone sensitivity in a patient with SLE is presented here.


However, the treatment can be associated with significant morbidity.


Cerebrospinal fluid examination prior to the last dosage of cytosine arabinoside revealed a mononuclear pleocytosis and increased protein.


However, in instances of spontaneous TLS complicated by the normally low glomerular filtration rate in the newborn infant, the use of rasburicase and other supportive care measures may still be inadequate, warranting further study.


A 77-year-old woman with no history of epilepsy presented a probable nonconvulsive status epilepticus while receiving continuous intravenous morphine for back pain relating to vertebral metastasis of a malignant lymphoma.


We suspect that extrapyramidal signs in this case could be a result of acute brain injury because of the massive copper release from liver to the circulation just before and during LT.


Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.


The literature of vincristine optic nerve toxicity is reviewed.


A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.


Bladder biopsies demonstrated massive eosinophilic infiltration of the bladder, confirming the diagnosis of eosinophilic cystitis.


In both patients therapy with high dose acyclovir, 10 mg/kg q8h, intravenously, was instituted based on clinical presentation.


This 4-year-6-month-old girl had a history of moderate developmental delay and had received HOPA administration when first admitted at 2 years 6 months of age with hypoglycemia, hyperammonemia, lactic and pyruvic acidemia, and non-ketotic dicarboxylic aciduria.


PURPOSE: To report cerebral venous thrombosis as a complication of intravenous corticosteroid treatment in a patient with multiple sclerosis.


Use of baclofen in the treatment of esophageal stent-related hiccups.


Continuous subcutaneously administered desferrioxamine may prove to be adaptable for long-term outpatient therapy, allowing patients with ongoing transfusion requirements to go into negative iron balance.


CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.


Histopathology of the lesions was compatible with pemphigus foliaceus, although apoptotic cells suggestive of erythema multiforme were seen in two cases.


Although the precise etiology is unknown, the Epstein-Barr virus and immunosuppressive agents appear to he risk factors.


This report suggests that the poor prognosis previously given to fetuses exposed to disulfiram in the first trimester may not be warranted.


This report describes a case of perforated appendicitis and ectopic pregnancy following in-vitro fertilization (IVF) and embryo transfer.


She only assumed isotretinoin, at dose of 1 mg/kg a day, for a severe and scarring acne for 7 months.


Most current guidelines for the management of anaphylaxis list only epinephrine as a vasopressor to use in the event of cardiovascular collapse.


Complete rupture of the posterior tibial tendon occurs infrequently.


Cerebrospinal fluid examination showed albuminocytologic dissociation (total protein concentration 118 mg/dl and 152 mg/dl, respectively).


There was a progressive increment in corneal thickness and consequent improvement in corneal transparency, curvature, and regularity.


In conclusion, TVUS can fail to detect cancers if the endometrial lining is not enlarged.


Little inflammatory change was noted in either the epithelial or stromal layers of the failed graft.


The case was a 17-year-old schoolboy presenting with vomiting, features of infection and gastrointestinal tract symptoms.


Spinal nerve block by intrathecal phenol-glycerine infusion is commonly employed for relief of severe pain in terminal carcinomatosis and, frequently, a dramatic regional anesthetic effect is achieved.


In addition, we know of no evidence specific to the treatment effect of epoetin alfa and/or darbepoetin alfa on A1C.


This complication may have been due to shrinking of the tumor as well as thrombocytopenia following chemotherapy.


Oestrogen cream can be used in an attempt to minimise the adverse reaction and speed the healing process.


Cytostatic extravasation via central catheter is an uncommon complication in clinical practice.


In addition, HD alone should be used to remove any excessive amounts of AZ from the blood.


Based on 2 case presentations - acute renal failure (ARF) due to myeloma kidney and due to angiotensin-converting enzyme inhibitor administration in the presence of transplant artery stenosis - new aspects in the pathogenesis of ARF are presented and discussed.


SIRT is a palliative treatment for unresectable liver tumours.


The patient had previously reacted similarly to ampicillin infusion.


Further genetic testing of autopsy tissue revealed the presence of a gene defect at the cytochrome P450 CYP2D locus, which results in poor metabolism of fluoxetine.


Long use of cyclosporine improved the proteinuria and hypoalbuminemia within 12 months.


A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen.


A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim.


Prospective randomized combination trials similar to the Intergroup Rhabdomyosarcoma Study in the pediatric population are necessary to better understand and manage these potentially curable sarcomas.


These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.


On December 18, 2007, she was admitted to the cardiology unit to undergo a pacemaker replacement.


Patients not treated with hemodialysis have increased morbidity and significant prolongation of their hospital course.


Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.


Methyldopa was discontinued, but after exhibiting transient clinical improvement, the patient's condition progressively deteriorated until she died of hepatic failure, in spite of therapy with massive doses of corticosteroids and other nonspecific measures.


Monsel's solution impregnated into a uterine pack was used to secure hemostasis.


As EGFR inhibitors are now incorporated with chemotherapy in advanced pancreatic cancers, clinicians should be aware of this potential complication.


Recently, amiloride, a potassium-sparing diuretic, has been reported as a successful treatment for nephrogenic diabetes insipidus.


The ulcers slowly healed with local therapy, but two patients required dose modification of the pegylated interferon alfa-2b and one patient required treatment withdrawal.


Neither corticosteroids, osmotic diuretics, hemodilution nor surgical decompression of the optic nerve have proved successful.


Agranulocytosis and granulocytopenia associated with quetiapine.


Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.


The lamellar inflammation was refractory to topical steroids and only resolved when pressure was controlled.


Danaparoid was restarted 3 h post delivery and the patient anticoagulated with warfarin in the post-partum period.


Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.


In contrast, eosinophil infiltration was rare in polyps obtained immediately after steroid treatment.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).


We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.


We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.


Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.


These findings were consistent with the posterior reversible encephalopathy syndrome.


She was treated with Pancrease MT 16, but had consistent vomiting 1 to 2 hours after administration of enzymes.


She was diagnosed with porphyria after the fifth hospitalization.


Our observation suggests that corticosteroid therapy may be beneficial in some patients with CE.


The syndrome of "painful legs and moving toes" is characterised by spontaneous causalgic pain in the lower extremities associated with peculiar involuntary movements of the toes and feet.


Adjuvant chemotherapy is frequently used for the treatment of early stage breast cancer, and to date there has been no increase in the incidence of secondary myelodysplastic syndromes or acute leukemia after cyclophosphamide-based regimens when compared with surgical controls.


A patient taking excessive amounts of an ergot alkaloid for the treatment of migraine headaches developed cool, painful, swollen lower extremities with intermittent claudication and sensory changes.


The possible relationship between transplant-induced immune dysfunction and the occurrence of this rare infection is discussed.


A Flexiflo Inverta percutaneous endoscopic gastrostomy tube was successfully inserted by pull technique.


Overall, five of the seven patients were rated at least minimally improved in behavioural symptoms.


Patients with huge tumor mass and multiple liver metastases have increased risk of tumor-induced hypoglycemia.


All patients having INFVA respiratory infection were treated by oral oseltamivir 60 mg/day, begun more than 48 h after symptom onset.


Fluorouracil for allergic reactions to capecitabine.


The mother also falsified the laboratory data to erase from her daughter's file a laboratory result documenting warfarin in the blood.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


In one recording a short period of regular sinus rhythm with intermittent 2/1 S-A block was observed.


In the meantime the patient developed acute respiratory distress, was intubated on clinical grounds and was transferred to the intensive care unit.


Calcium intake in these infants was far below that achieved by fetuses of comparable age in utero, even though in excess of that provided by usual premature infant oral formulas.


The onset and duration of symptoms correlated directly to drug ingestion.


This report describes a 13-year-old female with a right frontal high-grade glioma and complex partial seizures who developed localized purpura after 23 months of lamotrigine monotherapy.


While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.


Five of the patients received no radiotherapy.


After discontinuation she developed adrenal insufficiency, for which she needed substitution of steroids.


The authors describe a case of neuroleptic malignant syndrome that occurred in a patient on amitriptyline and lithium carbonate.


The CYP2D6 phenotype, determined when the patient received the antidepressant comedication, characterized a poor metabolizer status (dextromethorphan metabolic ratio >0.3), despite a heterozygous genotype containing a wild-type allele with extensive metabolic capacity and a mutant non-functional allele (CYP2D6*1A/CYP2D6*4A).


A kidney transplantation recipient 1983 to 1995, she was diagnosed with Charcot-Marie Tooth disease in 1991.


IMPLICATIONS: Dexmedetomidine, an alpha(2)-adrenoceptor agonist, is indicated for sedating patients on mechanical ventilation.


Urethral syndrome patients have irritative bladder symptoms in the absence of any objective urological findings.


RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.


A review of the literature indicates that even when given at much higher doses than are needed for treating heroin or alcohol abusers, there is no evidence that NTX causes clinically significant liver disease or exacerbates, even at high doses, serious pre-existing liver disease.


This paper reports on a 6.9-year-old autistic male who developed repeated episodes of acute dystonic reactions associated with pimozide administration at the doses of 0.096 mg/kg/day and 0.032 mg/kg/day and 32 hours following pimozide withdrawal, as well as during subsequent thioridazine administration.


Four patients with severe lactic acidosis associated with septic shock were treated with sodium dichloroacetate (DCA) (50 mg/kg body wt), an activator of pyruvate dehydrogenase.


It is suggested that an allergic background may play an important role in the development of EP in patients on CAPD.


The high rate of retinopathy in patients with hypertension suggests that patients should be carefully monitored.


We describe the clinical, radiological and pathologic findings of a case of epithelioid angiosarcoma of the lung presenting with persistent haemoptysis who had undergone remote lung collapse therapy with Lucite plombage.


Clinicians should be aware of this risk and ask about it during routine clinic follow-up for spasticity.


Following three courses of chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF), the patient had a dramatic clinical reduction of tumor, reduction of serum CA 15-3 from 161 to 64 U/ml, and underwent a modified radical mastectomy and axillary dissection.


A 73-year-old man was admitted for treatment of pleural dissemination that was a recurrence after right lower bilectomy for advanced lung cancer.


Although interferon gamma has been implicated in the pathogenesis of sarcoidosis, only a few cases of sarcoidosis associated with interferon alpha therapy have been reported.


Concomitant irradiation apparently enhanced the skin toxicity of aminoglutethimide or possibly aminoglutethimide had a radiosensitizing role in this patient.


Ectopic adrenocorticotrophic (ACTH) syndrome and small cell carcinoma of the lung-assessment of clinical implications in patients on combination chemotherapy.


Major points illustrated are, (1) occurrence of HIT with any dose or form of heparin; (2) misperceptions on the diagnostic criteria; (3) correct (thrombin inhibitors) and incorrect (platelet transfusions and warfarin) management; (4) influence of management strategy on clinical outcomes; (5) severity of the syndrome; and (6) potential for both anamnestic response to heparin and disappearance of HIT antibodies over time.


A patient who had been treated with large doses of thyroid hormone for several years developed features of secondary hypothyroidism after thyroid hormone withdrawal.


Faultless aseptic technique is essential when administering hyaluronate viscosupplementation.


In vitro lymphocyte transformation studies confirmed cross-reactivity to one or more aromatic AEDs in 3 patients.


When platinum-containing agents are administered, patients should be closely monitored for hypersensitivity reactions, even in previously uncomplicated cases.


CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.


Symptoms are usually considered nonspecific, and gastroscopy with biopsy is usually performed to establish the diagnosis.


Captopril-induced acute reversible renal failure.


Both these cases of PTLD achieved a complete response following treatment with IVIG, gancyclovir, solumedrol and interferon (IFN).


CONCLUSIONS: The value of multihormonal therapy in breast carcinoma is not established, and the addition of progestogens to tamoxifen may not reduce of developing endometrial lesions, including carcinoma.


Intrathecal methotrexate-induced acute cerebellar syndrome.


Neonatal mydriasis: intravenous lidocaine adverse reaction.


Phenolphthalein-induced toxic epidermal necrolysis.


MRI with gadolinium enhancement demonstrated prominent multifocal enhancing white matter lesions.


Mycophenolate mofetil may be considered as a useful alternative in the treatment of severe myasthenia gravis when standard therapeutic regimens fail.


The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.


During the course of chemotherapy, HBsAg gradually became positive, but no liver dysfunction was apparent until after completion of the chemotherapy.


After two months of hospitalization, a pruritic dermatitis near the left scapula developed.


A Chinese female with 10 years' history of a special form of tardive dystonia (Pisa syndrome) is described.


It has minimal side effects in transplant recipients and appears to be an effective initial treatment for this severe infection.


Sclerodermatous syndrome after occupational exposure to herbicides--response to systemic steroids.


We describe the development of ischemic colitis in a woman who was treated with tegaserod and review the relationship among ischemic colitis, tegaserod use, and irritable bowel syndrome.


Severely elevated serum lithium levels were found.


We describe a renal transplant recipient maintained on cyclosporine and prednisone developing Nocardia Asteroides brain abscess.


Drug rash with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe adverse drug reaction affecting multiple organs caused by drug treatment.


CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.


Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.


The most remarkable feature was the presence of diamond-shaped Russell bodies in 20% of the plasma cells of the second biopsy specimen.


Occasionally missed doses may lead to pervasive non-adherence with relapse a likely outcome.


In each case, control was achieved rapidly after initiation and titration of a continuous haloperidol infusion.


Treatment was discontinued; the patient was managed with monitored IV hydration and loop diuretics, high dose corticosteroids and fresh frozen plasma infusions and recovered completely.


Hairy cell leukemia, a low-grade B-cell lymphoproliferation, has not been recognized as part of the PTLD spectrum.


We reviewed the literature for similar cases of aortoiliac thrombosis in newborns; some were managed by medical means, others by operation.


Drug-drug interaction between itraconazole and efavirenz in a patient with AIDS and disseminated histoplasmosis.


Six (25%) of 24 patients died of this infection; however, only one (5%) of 19 who were treated with adequate antimicrobial therapy died.


The literature concerning formalin therapy is reviewed.


Eyelid necrosis following intralesional corticosteroid injection for capillary hemangioma.


RESULTS: In one patient the rifampin-impregnated shunt system was implanted after external drainage to prevent further infection.


An extensive literature search revealed few previous reports of herbal drug induced EM and SJS.


METHOD: Case report and review of the current literature concerning radiation-induced, secondary, space-occupying lesions.


Cefoxitin should either be used with great caution or not prescribed in combination with aminoglycoside antibiotics.


CASE SUMMARY: We report the case of a 31-year-old patient hospitalized due to behavioral alterations and treated with oral zuclopenthixol, an antipsychotic from the thioxanthene family, who developed an acute, painful erection.


Glomerulonephritis in procainamide induced lupus erythematosus: report of a case and review of the literature.


Childhood methanol ingestion treated with fomepizole and hemodialysis.


Two electrophysiological methods were performed for objective evaluation of retinal function, namely full-field electroretinography and multifocal electroretinography.


A review of the literature found 11 children and 2 adults in whom intranasal desmopressin was associated with hyponatremia, all of whom experienced seizures or altered mental status.


Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.


Successful treatment with dantrolene does not, however, preclude a recurrence of MH, and thus subsequent doses of dantrolene should be given.


In 1 patient, pericardial effusion associated with a pseudoaneurysm was discovered in the operating room.


A diagnosis of visceral varicella-zoster disease was made, and early intravenous ACV therapy successfully alleviated the epigastric pain and skin lesions within 2 weeks.


To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.


The major side effect of infliximab is infection.


One patient was treated symptomatically for the first 6 h until she was given dantrolene.


A patient presented with dilated cardiomyopathy after many years of overusing an adrenaline inhaler.


For example, the potent CYP2D6 inhibitor fluoxetine increases the plasma concentrations of tricyclic antidepressants.


Discontinuation of ergot-containing products and cessation of tobacco and caffeine use is the cornerstone of therapy in chronic ergot toxicity.


This case demonstrates the importance of screening electrocardiograms, even in healthy young patients.


We report a case of baclofen withdrawal syndrome resulting from oral baclofen underdosing.


The latter form (Macrodantin) is reported to engender less gastrointestinal intolerance but it can produce the same adverse effects as the conventional form--liver damage, acute and chronic pulmonary reactions, peripheral neuropathy, blood dyscrasias and allergic reactions--and does so just as rapidly and floridly; one such case is reported here.


Moreover special caution with treatment of leishmaniasis must be taken in renal transplant because of possible interactions between antimony compounds and ciclosporin metabolites.


Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.


CASE SUMMARY: A 77-year-old white woman presented to the hospital with elevated serum creatinine, oliguria for the past 24 hours, arthralgia, fatigue, fever, and bilateral flank pain.


Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin.


In both cases, spontaneous resolution occurred over several weeks following withdrawal of the drug.


Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.


Lymphotropic herpesviruses such as human herpesvirus type 6 (HHV-6) have enhanced pathogenicity in some immunocompromised hosts, such as transplant recipients and HIV-infected patients.


During admission she was found to be profoundly hypothyroid despite being on adequate thyroid replacement therapy.


Four recovered fully within 24 h, two recovered partially after 24 h and completely after 48 h while two recovered only after 72 h.


To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.


BACKGROUND: To describe the occurrence of ocular hypertension in four patients following injection of ranibizumab intravitreally.


Other thiazolidinediones currently in clinical trials may be able to provide the therapeutic benefits of troglitazone without significant hepatotoxicity.


Pneumonitis is emerging as one of the most unpredictable and potentially serious, adverse effects of treatment with MTX.


With aggressive supportive therapy, including hypertonic saline administration and hemodialysis, the patient fully recovered without detectable sequelae.


A unilateral fixed and dilated pupil was noted.


Hepatotoxicity induced by cyproterone acetate: a report of three cases.


Acute spontaneous tumor lysis syndrome in a patient with Crohn's disease taking immunosuppressants.


She was receiving several anti-tubercular drugs, including rifampicin, isonicotinic acid hydrazide (INH), pyrazinamide, and ethambutol, for abdominal tuberculosis.


Central nervous system imaging was negative.


The timolol was discontinued, and the patient's heart rate increased.


Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals.


RESULTS: Similar to previous findings of drug-induced vortex keratopathy, atovaquone vortex keratopathy is presumably caused by its lipophilic properties.


There was no reaction associated with thioridazine and/or haloperidol.


We believe that this impairment in driving performance, due to deliberate overuse of dopaminergic medication, should be included as a new behavioural phenomenon in dopamine dysregulation syndrome.


Patients underwent standardized MRI within 48 h of symptom onset; MRI included DWI and apparent diffusion coefficient (ADC) maps.


Four cases of adverse experiences with clonidine are described.


A 10-year-old female with atopic eczema developed eczema herpeticum after hot tub use with a friend who had "fever blisters"; herpes simplex virus was recovered from cutaneous vesicles.


A combination of behavioural and cognitive adverse effects is illustrated in this case report of a recurrent triazolam-induced eating disorder.


A review of the literature indicates that, with one possible exception, this complication has not occurred in a CS-dependent subject with asthma.


OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.


This observation illustrates that the pharmacological activation of the parathyroid CaR and other putative CaR on bone cells by calcimimetics did not protect against the occurrence of hypercalcemia of immobilization favored by a severe HPTH-II in a hemodialysis patient.


These questions are considered in the context of currently available literature.


An autopsy case without intrathecal chemotherapy or irradiation of the brain.


Complete remission was obtained in 4 (57%) and partial remission in 3 (42.8%) of 7 evaluable patients.


Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria.


The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.


METHODS: An open-label unmasked prospective nonrandomized pilot study of six patients with idiopathic uveitis and visually significant macular oedema, resistant to periocular and/or systemic corticosteroid treatment, was carried out.


Five patients (ages 23-52; UNOS status 3-4) exhibited a characteristic pattern of stuttering dysarthria, leading to complete loss of speech production, occasionally with elements of aphasia.


She had been treated without complications with six courses of docetaxel and trastuzumab in combination with dexamethasone with partial remission of disease.


The evidence linking disorders of anger and impulse control to a dysregulation in neurotransmitter regulation, particularly in serotonergic pathways, supports a psychopharmacologic approach to treatment.


OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia.


Typically, regional sympathetic blockade or sympathectomy is employed.


She was treated with LAM, and her serum HBV DNA turned undetectable 2 weeks later.


Moreover, the in vitro culture of bone marrow from a second HS patient showed a GM-CSF dose-related increase in colony formation up to a dose of 250 units/ml.


Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.


BACKGROUND: Contact allergy to corticosteroids has recently gained increased attention.


Deterioration in renal function associated with angiotensin converting enzyme inhibitor therapy is not always reversible.


Intravitreal triamcinolone acetonide for persisting cystoid macular edema after penetrating keratoplasty.


The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.


Immediate postoperative cystogram and pelvic computed tomogram (CT) after the development of seizures demonstrated a fluid collection from the suprapubic catheter site into the anterior abdominal wall.


A skin biopsy showed hydropic degeneration of keratinocytes and lymphocytic infiltrate.


A detailed study has been made of the five hypertensive patients who received Minoxidil in Dumfries; four have been observed for over a year.


Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.


Emergency compartmental pressure measurement may indicate fasciotomy, can be of great interest.


Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.


The successful use of streptokinase therapy in a child with chronic thrombosis of a prosthetic valve (Carbomedics) in the tricuspid position is presented.


One of the etiologic factors of this disorder is prolonged prostaglandin E1 (PGE1) therapy of neonates with congenital cyanotic heart diseases.


Serum creatine kinase (CK), liver function tests and a light microscopy muscle biopsy were performed on all of them.


Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.


Further controlled clinical investigations are necessary to evaluate change in weight during treatment with olanzapine ODT, and to improve our understanding of this change.


Anaesthesiologists and physicians dealing with the management of Cushing's disease need to be aware of this possibility.


The liver damage was probably related to metabolic idiosyncrasy, and was reversible in all patients.


Drug poisoning was suspected on the basis of persistent tachycardia in the absence of other signs of dehydration.


Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.


Future studies should address whether FSGS represents a glomerular response to anthracycline-induced injury in susceptible black persons.


Dipyrone, also known as metamizole, is an analgesic and antipyretic drug that was banned by the United States Food and Drug Administration because of its association with agranulocytosis.


The clinical course of this case indicates that IFN therapy precedes IDDM.


Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.


In June 2002, the patient was admitted to the Outpatient Clinic of the Rheumatology Unit for arthralgia affecting the small joints, non-pruritic crops of purple skin lesions and malar rash in the face.


Limb dysfunction can be prolonged.


The third was a 16-year-old male who developed a profound peripheral and central neuropathy after chemotherapy treatment for T-cell acute lymphoblastic leukemia.


Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.


We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor.


The alternative use of endovascular stent-grafts was evaluated for management of infected aneurysms of the thoracic aorta.


To optimize future management of this problem we studied 2 poorly recognized factors in the pathogenesis and prognosis of genitourinary malacoplakia in transplant recipients: 1) the probable role of azathioprine as the specific immunosuppressive agent responsible for the pathogenesis of malacoplakia, and 2) the importance of the localization of the disease and its impact on the ultimate prognosis.


Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.


Functional neuroendocrine tumors are often low-grade malignant neoplasms that can be cured by surgery if detected early, and such detection may in turn be accelerated by the recognition of neuropeptide hypersecretion syndromes.


The colonic lesion was conveniently removed and the histology evaluation confirmed the diagnosis of adenocarcinoma tubular.


Although we hope the discovery of the FMF gene will allow the diagnosis of FMF to become genetically accurate, the reality is that both clinical and genetic tools must still be used together unless mutations are identified on both of a patient's chromosomes.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


He was then scheduled to receive adjuvant chemotherapy with high-dose MTX, 12 g/m2 body surface area, followed by leucovorin rescue and ifosfamide.


Five patients were treated with dose-intensive melphalan and blood stem cell support and followed for a period of 1 year.


Pulmonary edema occurred 24 hours after intravenous ritodrine therapy and 10 hours after subcutaneous terbutaline therapy.


Fatal agranulocytosis in an Indian male receiving 100mg of dapsone daily, hospitalized for mid-borderline leprosy in type I reaction with triple nerve paralysis is reported.


Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.


A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.


All patients had normal levels of thyroid-stimulating hormone and no other gastrointestinal complaints; evaluation revealed no other cause for the weight loss.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


METHODS: Three patients with apparent itraconazole-induced liver injury were studied.


For effective treatment of bacterial osteomyelitis a bone biopsy is sometimes unavoidable and indicated.


During monitoring, visual hallucinations did not correlate with EEG readings, nor did video recording capture any of the described events.


To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.


No patients died.


Imatinib has remarkably improved the prognosis of patients with CML.


The importance of early recognition of postsplenectomy sepsis (PSS) is emphasised since the survival rate is poor and the risk of visual loss high.


Osteomyelitis occurring during infliximab treatment of severe psoriasis.


Supportive management was the mainstay of therapy.


Their age range was 44 to 66 years.


A 52-year-old woman developed symmetric sensorimotor polyneuropathy and cerebellar syndrome after 24 months of amiodarone treatment.


We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.


We report on a 14-year-old boy with acute lymphoblastic leukemia (lymphoma-leukemia) who had two episodes of acute tumor lysis syndrome during induction of remission with oral prednisolone alone and oral prednisolone, intravenous vincristine, and doxorubicin, respectively.


The patient was readmitted with symptoms of rhinorrhea, poor feeding, and decreased activity level.


Antihistamines did not inhibit the LAR but totally or partially inhibited the immediate response.


A 57-year-old woman was hospitalized because of gait disturbance and dysuria.


A review of four previously reported cases revealed that treatment with systemic glucocorticoid and CsA was effective for the DM and PnM.


RESULTS: SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment (IS/OS) junction and a downward "sink-hole" displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


In contrast, newer North American guidelines have focused on the severity of illness of community-acquired pneumonia.


Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.


It is now recognized that magnesium plays an important role in calcium homeostasis.


Transient panhypogammaglobulinaemia and B-lymphocyte deficiency in a patient with neuropsychiatric systemic lupus erythematosus after immunosuppressive therapy.


However, EO-induced noncardiogenic pulmonary edema has not been reported in human.


After unsuccessful fluid resuscitation with crystalloid fluid, the patient's condition improved rapidly with human albumin boluses.


Inappropriate antidiuretic hormone following adenine arabinoside administration.


Capecitabine reaches peak blood concentrations in about 1.5 hours, with peak fluorouracil concentrations occurring at 2 hours.


The patient was brought to an intensive care unit 10 hours after intake of 1200 mg mirtazapine and 20 mg lorazepam and laying outside at outdoor temperatures below 0 degree C.


Using a medical emergency team to manage anaphylactic shock.


Damage was related to both daily dose and duration of therapy and was occurring at a greater rate than its repair.


Recommended treatment duration is 6 to 12 months with frequent imaging.


Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.


We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria.


Both the clinical picture of the patient as well as laboratory, imaging and histopathological findings may help in the diagnosis.


All of these have been able to reduce oral prednisone doses.


Both infiltrates initially improved on topical antibiotic therapy, but over the next 18 days, 1 infiltrate worsened and repeat cultures were performed, which demonstrated A fumigatus.


We report the case of a 14-year-old female with acute promyelocytic leukemia who developed symptomatic cardiomyopathy only 4 months into treatment with a combination of daunomycin and all-trans retinoic acid (ATRA).


One victim was hospitalized.


Myasthenia gravis is an autoimmune disorder where antibodies against the nicotinic Ach receptor resulting in impaired transmission at the NM junction.


Hydrocortisone may decrease the incidence of mortality associated with cardiac arrhythmias in children receiving amphotericin B overdoses.


It may also appear in complete remission after chemotherapy (chemotherapy-related).


We report three cases of ehrlichiosis in pediatric oncology patients, one of whom was a stem cell transplant recipient.


Bone marrow needle aspirate showed a normal trilineage differentiation.


Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.


The probability of developing acute leukemia in this study was not significantly correlated to the total cumulative dosage of Treosulfan.


All of them had the obstructive type of HCM (HOCM).


Electromyogram and nerve conduction studies showed sensorimotor peripheral neuropathy in both patients.


Appropriate treatment for neurosyphilis was instituted.


The patient's clinical presentation, histologic features on liver biopsy and favorable course after stopping the drug suggest that barbiturates can be added to the list of agents which can cause submassive hepatic necrosis.


Complete resolution of the diarrhea occurred shortly thereafter.


Mesenteric desmoid tumors are a recognized sequela of colectomy for polyposis coli of Gardner's type.


Acute enlargement and subsequent rupture of an abdominal aortic aneurysm in a patient receiving chemotherapy for pancreatic carcinoma.


Granulocytic sarcoma: local presentation of a systemic disease.


METHODS AND RESULTS: A case of high grade superficial bladder caner treated with intravesical BCG which has successfully cleared her bladder cancer nevertheless has lead to bladder contracture for which case she may need bladder reconstruction/augmentation surgery if she remained disease free added to her psychological and social effects on her life.


Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.


The patient had been receiving bisphosphonate therapy prior to admission and this may have contributed to the severity of the problem.


In addition to its known effect on gallbladder stasis, octreotide alters bile acid composition and may thus hasten intrahepatic sludge and stone formation.


The potential risk of carcinogenicity has delayed more extensive clinical trials.


Efforts to reduce the glucose levels and long-term complications increase the frequency of hypoglycemia.


There was no evidence of disease progression.


Twenty-seven consecutive patients admitted for an acute CAD were investigated using a standardized imaging protocol.


No guidelines exist for calculating doses by either actual or ideal weight, and the calculated doses may vary by as much as 25%.


We present two cases of neonates with gastric mucosa and submucosa hyperplasia revealed during ultrasound examination.


Routine ophthalmic observation for the development of optic neuropathy is strongly recommended for patients with significant risk factors that could increase the chance of side effects and those on longer treatment courses.


The TC usually develop in the presence of secondary hyperparathyroidism or a high calcium x phosphate product, while other factors have been also occasionally implicated in their development.


Treatment with amiodarone was continued; however, therapy with L-thyroxin was initiated, followed by a complete regression of the goiter.


Aggressive use of H2-antagonists to prevent gastrointestinal bleeding in septic patients will reduce the need for orally administered antacids.


A week before the onset of hepatitis, the patient complained of upper gastrointestinal symptoms and was treated for gastritis.


Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment.


It appears that this secondary malignancy was due to his prolonged chemotherapy.


PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy.


After 1 month of follow-up the patient underwent TEE which showed a dramatic reduction of the left atrial thrombosis.


After first and second line chemotherapy we started third line chemotherapy consisting of calcium folinate (1,000 mg) and 5-FU (4,000 mg) mixed together in a total volume of 240 ml in an ambulatory pump and administered over a period of 24 h.


We hypothesize that chronic inflammation of the pleura, caused by decades of empyema, associated with the presence of heterotopic squamous epithelium due to a long-standing esophago-pleural fistula, led to neoplastic transformation.


Forty-five days after therapy, the patient returned with a severe necrotizing uveitis in the posterior pole and vitritis.


An intertriginous eruption with histological features of epidermal dysmaturation and an interface dermatitis has been previously reported in the dermatopathology literature.


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


She had received this same dose in the past without incident.


Amlodipine was given for the treatment of hypertension.


The former had a slowly progressive course, did not respond to amphotericin B (AB), and died; the latter improved after a prolonged course of liposomal-AB.


The expanded allele segregated with neurological signs in one kindred.


CONCLUSIONS: This study shows that psoriasis can be driven by the innate immune system through TLR ligation.


A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).


That time the only effective treatment was ventricular pacing.


For the treatment of the latter, early peritoneal dialysis is recommended for in utero exposure to captopril and enalapril, although the outcome is poor.


The patient had a favorable outcome.


Persistent CSF leak may also be present without PDPH.


Following therapy with AmBisome his symptoms abated and significantly improved scan picture was seen.


Our case illustrates the importance of continuing adequate opiate therapy perioperatively in the increasing number of opioid-dependent patients to prevent potentially life-threatening complications such as broken heart syndrome.


The usual treatment includes quick relief bronchodilator medications of the sympathomimetic class and controller medications that may include the long-acting inhaled bronchodilator salmeterol.


In recent years there has been an increase in the use of ACE inhibitors in the paediatric population.


The present case suggests that acute exacerbation of hepatitis can occur with steroid-free regimen.


To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.


Neuropsychologic evaluation revealed global cognitive deficits; he was found to be a carrier of a PS-1 point mutation at position G206A.


The patient survived pulmonary leukostasis, resumed therapy, and achieved a CR.


The patient's hematocrit eventually stabilized and was 30% at discharge.


Individual risk/benefit assessment is important, and close monitoring of both mother and child is advisable, especially during the first 3 weeks postpartum.


There are insufficient data about the use of immunosuppressive agents in the treatment of FMF attacks; however, we now successfully control the attacks with colchicine 0.5 mg/d and azathioprine 2 mg/kg/d.


Plasma concentrations were also measured before and after ten dialysis sessions during four courses of ifosfamide therapy.


First, a review of the literature produced 41 anecdotic cases of neutropenia or agranulocytosis during treatment with olanzapine (Zyprexa) reported in a total of 24 publications.


However, the impact of cytomegalovirus on PTLD remains to be determined.


Microscopic examination of a skin scraping revealed a heavy infestation of cheyletiella yasguri, as identified by the presence of hoks of the palpi and the heart-shaped sensory organ on genu I.


Acute generalized exanthematous pustulosis induced by salazosulfapyridine in a patient with ulcerative colitis.


A 57-year-old woman was scheduled to receive recombinant interferon-alpha retreatment for chronic active hepatitis C.


We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.


We report a case of severe hypotension associated with intravenous valproate used to treat status epilepticus in an 11-year-old girl.


CONCLUSION: The final interpretation of the lesions was multiple focal radiation necrosis based on perfusion abnormalities after chemotherapy and conformal hyperfractionated radiotherapy, probably due to an individually enhanced vulnerability of the cerebral vessels.


This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.


However, little has been reported about conditions surrounding the change in QT interval after the steady state is achieved that may have implications in the safety and efficacy of the drug.


Subsequently, the patient again became severely leukopenic (WBC count 2.4 x 10(3)/microL).


Amebic keratitis was diagnosed following corneal biopsy and cultures which grew Acanthamoeba of a species similar to, but not identical with, Acanthamoeba polyphaga.


Recurrent fractures in an elderly patient with systemic lupus erythematosus.


The diagnosis, pathogenesis and issues relevant to the treatment of this condition are discussed.


Drugs metabolized by the same enzyme may interact with each other.


Neuroleptic malignant syndrome in a patient with succinic semialdehyde dehydrogenase deficiency.


Two months later, a second arrhythmia cluster occurred that was controlled by the addition of amiodarone.


While acute toxicity is not infrequently reported, a recent experience in an adult who received five consecutive daily doses of VCR (1.0 mg/m2) in conjunction with two other drugs led to a sequence of life-threatening toxicities which were not obviously ameliorated by folinic acid rescue as has been recently advocated.


PURPOSE: A case of probable enoxaparin-induced hepatotoxicity is described.


OBJECTIVE: This article discusses the management of an insulin dependent diabetic man aged 52 years presenting with 17 torso basal cell carcinomas (BCCs); mostly superficial BCCs (SBCCs).


After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy.


The patient died in 1995 March at the age of 29 years of sudden septic shock related to Pseudomonas aeruginosa infection.


PURPOSE: The differentiating characteristics in blebitis and early and late endophthalmitis after glaucoma filtration surgery are reviewed.


Sildenafil should be considered in the treatment of PLE after the Fontan procedure.


Gastrointestinal hemorrhage due to duodenal erosion by a biliary wallstent.


Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence.


This association should be considered in the period after vasopressin-treated gastrointestinal hemorrhage.


It cannot be assumed that the development of a mediastinal mass or its persistence following chemotherapy is due to recurrent or residual disease.


These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.


Both reactions were categorized as probable according to the Naranjo probability scale.


Neurotoxicity is a common complication during cancer chemotherapy.


It is reversible with discontinuation of drug and administration of corticosteroids.


A single-pass tunneling technique for CSF shunting procedures.


These changes were associated temporally with cyproheptadine dosing.


Capillary leak syndrome (CLS) commonly occurs in the intensive care setting.


Hyperinfection with strongyloides following treatment with systemic steroids explains the presence of eosinophilia and splenic involvement.


Knowledge of this interaction and adjustment of the dose of phenytoin should enable clinicians to avoid this adverse drug interaction.


It is important for clinicians to recognize beta-lactam-induced leukopenia and maybe recommend use of a drug from a different antibiotic class if continued treatment is indicated.


De novo absence status is a specific epileptic condition that should be suspected in all elderly subjects on chronic treatment with psychotropic drugs presenting in a confusional state.


Intravenous mitozantrone was given for 2 years and she is asymptomatic, with computed tomographic evidence of tumour response, 27 months after diagnosis.


The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.


Discussion includes a review of the literature with respect to the relative merits of daily oral cyclophosphamide versus pulse intravenous cyclophosphamide in WG and other vasculitides.


This pediatric case report describes a massive overdose without significant side effects, thus suggesting a beneficial therapeutic index in pediatric patients.


Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.


Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.


RESULTS: Complete thrombosis of the mycotic aneurysms was achieved in all patients.


Experimental therapeutic approaches focus on the restitution of microcirculation (endothelin receptor antagonists, atriopeptins), interference with cast formation (integrin receptor blockers), and the promotion of recovery by growth factors.


GVHD occurs when immunologically active T lymphocytes are transplanted into an immunosuppressed recipient who is genetically disparate from the donor.


Robust guidelines and highlighting patients with risk factors are required to prevent this complication from recurring.


These features are similar to those observed previously in persistent light reactors to topical photosensitizers.


To avoid that toxicity, a new weekly schedule has been adopted in several Phase II studies.


Concomitant use of statins and cyclosporine should be avoided.


In this paper, we report a case of severe hypercalcemia of immobilization in a 40-year-old hemodialyzed woman treated by cinacalcet HCl for a severe HPTH-II (PTH>1,000 pg/mL).


The unmedicated eye remains asymptomatic to date.


Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.


When there was no laboratory confirmation of the arteritis, an iatrogenic etiology (ergotism) was suspected.


Hyperosmolar hyperglycemic nonketotic coma is a serious and often lethal clinical biochemical syndrome.


The mean +/- SD decrease in VAS at this time was 61.2 +/- 15.5%.


Neurologic manifestations of HIV infection are quite diverse and can develop into seizures.


After treatment for five months on this therapy, he presented with new-onset atrial fibrillation.


Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.