All patients in group 1 had positive serum antinuclear antibody titers, but none had positive serum anti-smooth muscle antibody titers.


FINDINGS: Six children with growth retardation noted after treatment with high-dose fluticasone propionate were found to have adrenal suppression.


Parkinsonism, pyramidal signs, polyneuropathy, and cognitive decline after long-term occupational solvent exposure.


A review of the literature suggests that leukoencephalopathy may be prevented by high doses of leucovorin and can be treated by high doses, if lower doses were used initially.


Infection of total hip prosthesis by Mycobacterium tuberculosis and Mycobacterium chelonae in a patient with rheumatoid arthritis.


Bull's-eye maculopathy associated with quinacrine therapy for malaria.


Practicing gastroenterologists and intensivists alike need to be aware of the potential for serious pulmonary sequelae with the use of combination therapy for chronic hepatitis C viral (CHCV) infections.


With careful sequential clinical and laboratory monitoring, even this type of cerebrospinal fluid shunt infection can be eradicated without catheter removal and replacement.


Perforated appendicitis was a coincidental event following IVF and embryo transfer.


Indomethacin and acetyl salicylate, which inhibit prostaglandin synthesis, had no significant effects on either the immediate or the LAR.


CONCLUSIONS: Life-threatening adrenal suppression, requiring hydrocortisone supplementation and intensive therapy, was observed and successfully treated in a newborn, whose mother had received high-dose methylprednisolone in late pregnancy.


Complete remission was achieved, however, severe neutropenia, documented infection, stomatitis, and diarrhea were observed.


Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.


The combined use of central nervous system depressant drugs, together with her problematic sleep apnea, and snoring (both contraindications for GHB use) were determined to have caused this subject's death.


A young woman developed galactorrhea during treatment with a new dibenzoxazepine antidepressant, amoxapine.


Lymphomatoid granulomatosis developed in a patient with pemphigus vulgaris who had been undergoing immunosuppressive therapy for three years.


Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.


Decreased plasma cortisol level during alprazolam treatment of panic disorder: a case report.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Carbamazepine interference with an immune assay for tricyclic antidepressants in plasma.


Tegaserod-associated ischemic colitis.


In 20 percent of affected individuals (9 percent of the total), sensory symptoms preceded the onset of the movement disorder, causing difficulty in diagnosis.


A 73-year-old woman on topical pilocarpine and adrenaline for chronic simple glaucoma for three years presented with a mass in the medial canthus of the right eye.


The trunk was twisted just after the appearance of the abdominal myoclonus associated with myoclonic jerks spreading from the rostral to caudal paraspinal muscles.


The authors suggest that these pharmacologic agents should be used cautiously in treating patients with possible movement disorders (tics) and conclude that their findings lend support to the catecholamine hypothesis of the etiology of Gilles de la Tourette's disease.


Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.


Palmoplantar pustular psoriasis (PPP) is an uncommon form of chronic psoriasis.


DISCUSSION: The main adverse effects of leflunomide consist of diarrhea, nausea, liver enzyme elevation, hypertension, alopecia, and allergic skin reactions.


We report an unusual case of massive fluoxetine ingestion resulting in neurological and cardiovascular toxicity resulting in death.


Defects noted include tooth and root agenesis, root thinning and shortening, and localized enamel defects.


A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months.


Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.


Once again, severe dyspnea, cough, and wheezing developed.


We conclude that cephalosporins of the first generation or ciprofloxacin may be good alternatives to penicillin G in the treatment of C. hominis infection in patients known to be hypersensitive to penicillin.


Urinary iodine excretion was extremely elevated up to 18 mg/day while serum concentrations of total thyroxine were below the euthyroid range and thyrotropin levels were elevated.


We evaluated both healthy ferrets and animals in which we first induced tracheal inflammation with bacterial endotoxin (a lipopolysaccharide [LPS]).


Bone marrow biopsy showed selectively inhibited erythropoiesis with giant pronormoblasts.


QPR/DPR and voriconazole are considered effective for patients with life-threatening opportunistic pulmonary infections who have previously been treated with intensive regimens including radiotherapies to the lung.


Although many of the patients have underlying heart disease, there are reports of patients with no evident heart disease where acute alcohol injestion has caused arrhythmias.


This is the first report of a middle-aged man with multiple coronary lesions.


Clinicians should consider placing a periosteal catheter when pain associated with sternal fracture cannot be adequately controlled with conventional methods.


Many organ systems may be affected.


The patient was treated with intraventricular and intravenous vancomycin, intravenous teicoplanin and oral rifampicin, followed by oral chloramphenicol and rifampicin.


In the present paper the authors describe 2 female patients who developed incontinence secondary to the selective serotonin reuptake inhibitors paroxetine and sertraline, as well as a third who developed this side effect on venlafaxine.


Despite percutaneous abscess drainage and antifungal therapy, general status deteriorated with persistent fever, severe pancytopenia and liver dysfunction.


We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.


CONCLUSION: This interference has significant clinical implications, and can be avoided on urine testing using a specific chromatographic assay such as high-performance liquid chromatography.


Intensified chemotherapy is one of the strategies currently used in the treatment of children with metastatic Ewing sarcoma.


Clinical report of three cases of acute radiation sickness from a (60)Co radiation accident in Henan Province in China.


In addition, growth failure was documented beginning at approximately 8 years; bone age was delayed and stimulated GH peaks after clonidine and arginine were 2.2 and 9.2 microg/l, respectively.


The rash was confluent over the radiation ports, both anteriorly and posteriorly.


BACKGROUND: Oxaliplatin is a platinum derivative, which is used in the treatment of colorectal cancer.


Phenytoin toxicity: an easily missed cause of cerebellar syndrome.


It represents one of the few documented cases of delayed clearance of echovirus in the cerebrospinal fluid in a patient with normal serum immunoglobulins.


Patient 2 presented an acute left hemiballismus when consciousness was restored with naloxone.


The condition responded to treatment with topical diluted steroids and antibiotics.


CASE SUMMARY: A 22-year-old male with cystic fibrosis had been nonadherent to treatment for 4 years; when he returned to the clinic with symptoms, his forced expiratory volume in 1 second dropped from 84% predicted to 43% predicted.


However, there are some recent reports on serious adverse events, probably associated with this complementary and alternative herbal medicine.


OBJECTIVES: To report a safe and reliable method for evaluating catheter dysfunction.


Papillary necrosis associated with the HIV protease inhibitor indinavir.


Two cases are presented with complicated FMF.


Alprazolam-induced mania: two clinical cases.


Bilateral simultaneous Achilles tendon ruptures are rare, with only ten cases reported in the English literature.


It is unclear if this effect is directly related to the administration of antileukotrienes or a consequence of the corticosteroid-sparing effect of antileukotrienes unmasking a Churg-Strauss syndrome.


DISCUSSION: Two patients with hypothyroidism had remained euthyroid and stable while receiving 1 levothyroxine product, but became symptomatic with dramatically increased serum TSH concentrations while receiving what were thought to be comparable dosages of another levothyroxine product.


Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration.


We report the case of a young healthy woman who presented an early overanticoagulation when receiving acenocoumarol for a first thromboembolic episode.


Pisa syndrome in a Chinese patient.


A 75-year-old man on anticoagulant therapy suddenly experienced an excruciating back pain and subsequently developed a paraplegia.


Before treatment with polyacrylamide gel injection this complication should be disclosed to the patient.


We report a case of IVC filter thrombosis with associated vena caval obstruction successfully treated with catheter-directed thrombolysis and adjunctive mechanical thrombectomy.


Seizures are uncommon symptoms, and are always caused by cerebrovascular events.


A 73-year-old woman with non-Hodgkin's lymphoma had two episodes of severe, bilateral, sensori-neural hearing loss after vincristine therapy.


As a result of the inadequate levels of antihepatitis B antibodies, less than 10 IU/l in May 1998, in a high-risk patient who was frequently exposed to blood and its products, an additional booster dose was performed.


Basilar invagination and mid-line skeletal abnormalities due to in utero exposure to phenytoin.


After admission, albumin-dominant proteinuria persisted despite the discontinuation of interferon therapy.


Strongyloides infection and meningitis in an immunocompromised host.


Over the next two days, the purpura began to resolve.


Deep tendon reflexes (DTR) were absent in all extremities.


Ten days following adrenalectomy, watery diarrhea appeared.


After developing two additional lesions that began to ulcerate despite treatment with imipenem, vancomycin, clindamycin, rifampin, and gentamicin, the patient consented to a skin biopsy.


Herein we present our case and a review of the literature about the systemic toxicity of PI.


Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.


Photo-onycholysis associated with drugs is an uncommon disorder.


Acute nitrite toxicity results from industrial exposure, accidental ingestion (e.g., abuse of organic nitrites as an aphrodisiac, especially in the male homosexual population), and suicidal ingestion.


The mycobacterial disease was eventually cured with clofazimine and the photosensitisation was managed by regulating sunlight exposure.


Fever and chills occurred on seven occasions.


Patient-initiated rapid atrial pacing to manage supraventricular tachycardia.


Acute radial artery ischemia following therapeutic steroid injection.


Pregnancy-induced hypertension laboratory values were normal, and relief of the postdural headache and visual disturbances was obtained after placement of an epidural blood patch.


Management of liver failure in a haemophilic patient co-infected with human immunodeficiency and hepatitis C viruses.


Manifestations included pleurisy in five of six patients, rashes in three, nephritis in two, and neurologic disturbances in two; lupus erythematosus cells were found in five patients, antinuclear antibodies in all six, antideoxyribonucleic acid in three, positive Coombs' test results for three patients, and low C4 complement in five of the six.


All patients receiving chronic corticosteroids should have an ophthalmologic examination early in the course of treatment and periodically thereafter.


Malignant lymphoma developed in the dorsum of the hand in a patient with a long-standing postmastectomy lymphedema.


Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.


METHODS: The clinical suspicion of chickenpox was rapidly confirmed in both cases by a Tzanck smear preparation, by viral cultures of the vesicle, serology, and skin biopsy.


A successful vascular procedure was achieved with full heparinization without subsequent thrombocytopenia or thrombotic or hemorrhagic complications.


Consistent and supportive psychotherapy for such patients is recommended for maintaining compliance, for pharmacotherapy, and an optimal level of personal, occupational, and interpersonal functioning.


Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia.


This patient did not have any predisposing factors for the development of an aortic thrombus before the chemotherapy was initiated.


Until then, clinicians need to be aware of this possible complication associated with zonisamide.


After treatment with prednisolone a complete resolution of the dyspnea was observed.


BACKGROUND: Angiosarcoma arising after radiation is described in breast cancer but occurs elsewhere.


This case illustrates a potential risk associated with drug eluting stent and alerts clinicians to the life threatening risk of spasm when stenting multiple vessels with drug eluting stent (especially the Taxus stent).


Symptoms were rapidly controlled after a therapeutic dose was attained, and no adverse effects were reported.


The bite site included hand (52%), foot (36%), leg (7%), and arm (5%).


Hypocalcemia is a frequent finding during the correction phase of the HPTH-II with calcimimetics.


Infections are a major adverse effect during the treatment with anti-TNF-alpha.


FDG PET, performed after the size and number of the lesions had increased, showed no intensely increased glucose metabolism, a high-grade recurrent tumor was therefore very unlikely.


He presented the following day with uncorrected visual acuity (UCVA) in the affected eye of 3/200 and organic foreign body deposits underneath the flap.


Taste and smell changes (TSCs) are known side effects of chemotherapy, but smell changes (SCs) in the absence of taste changes are understudied.


We report the use of granulocyte colony-stimulating factor (G-CSF) in a renal transplant recipient in whom neutropenia developed following a presumed viral infection.


Zoledronic acid-induced severe hypocalcaemia in a prostate cancer patient with extensive osteoblastic bone metastases.


Antithyroid treatment with propylthiouracil (PTU) resulted in elevated hepatic enzymes and after the 12th week of pregnancy treatment was changed to carbimazole (CBZ).


This is a rare case of ARDS associated with lithium intoxication.


Immediate but gradual improvement followed withdrawal of amiodarone and treatment with prednisolone.


Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.


Uncertainty in medical decision making techniques occurs in the specification of both decision tree probabilities and utilities.


There is a great deal of interest in the long-term effects of chemotherapy in these patients.


A general physical examination revealed a boy with stable vital signs and without fever.


Ileus after administration of cold remedy in an elderly diabetic patient treated with acarbose.


There were no other known risk factors for vascular disease.


Hypersensitivity to carboplatin is a rare but real complication of therapy and should be considered in patients presenting with hyperacute changes on ECG whilst receiving carboplatin therapy.


This paper reports a patient with degenerative rupture of the plantar fascia.


OBJECTIVE: To report the occurrence of anaphylactoid reactions to intraperitoneal cisplatin in 3 patients.


They presented with parkinsonism, pyramidal signs, mild cognitive decline, and unresponsiveness to levodopa.


Introduction of etanercept was also clinically effective but followed by development of severe heart failure.


To our knowledge, this is the first reported case of drug-induced lung disease involving a leukotriene.


CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.


Some chemicals can cause burning in the mucosa of cheeks, lips, tongue, and palate.


He developed a metastatic carcinoma of unknown origin during TKI therapy.


METHODS: The patient underwent ocular examination.


This case demonstrates the value of DWI in evaluation and diagnosis of sub-acute toxic leukoencephalopathy in patients being treated with methotrexate.


A historical review of the adverse reactions to neuroleptic agents--extrapyramidal side effects--is presented.


Aspergillus cholangitis: A late complication after Kasai portoenterostomy.


The topographic distribution of these changes was typical of WE.


The patient had recurrence of urticaria and angioedema a year and a half later, at which point the NPH was stopped and she was desensitized to regular insulin.


At the time when the leukemia appeared seven of the patients were in complete, and one in partial, remission as regards the ovarian carcinoma.


The scant literature available on nonpigmenting fixed drug eruptions is reviewed.


Mean sleep latency with L-dopa was 7 minutes, in contrast to a normal value of 19 minutes, 25 seconds with placebo.


Two case reports of bilateral granulomatous anterior uveitis are described in patients with open angle glaucoma treated with metripranolol 0.6% eye drops.


We report a 58-year-old otherwise healthy woman with unilateral endophytic optic disc hemangioma and associated serous retinal detachment and exudation.


Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.


Focal nodular hyperplasia associated with the use of a synthetic anabolic androgen.


Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.


Other treatment modalities included high dose corticosteroids, plasmapheresis, lithium and perchlorate.


The criteria proposed by Earnest et al. should be implemented for each seizure case that requires a decision on the urgent need for therapeutic anticonvulsant levels, whether by mechanical infusion, manual intravenous push, or oral loading.


When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter.


The physician should be aware of this complication before in initiating treatment with this drug.


Micrococcus luteus pneumonia: a case report and review of the literature.


More recently, however, thalidomide treatment has been reintroduced to adult and paediatric practice for a variety of dermatologic, immunologic, rheumatologic and neoplastic disorders.


AmBisome treatment of fungal sinusitis in severe immunocompromised patient with acute lymphoblastic leukemia relapsed after autologous peripheral blood transplantation.


It is said that leprosy reaction should be properly classified for therapeutic reasons, since it is well known that in Lucio phenomenon there is not a good response to thalidomide.


Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.


He had been taking finasteride (Propecia; Merck, Sharp and Dohme) at 1 mg/day for 3 years to treat early stage of androgenic alopecia.


Massive vulvar edema complicating tocolysis in a patient with twins.


Following the first episode, he was eucalcemic for nine weeks without therapy, attesting to the prolonged biological effects of calcitriol when used in the treatment of hypoparathyroidism.


We advise careful monitoring of water-electrolytic balance during sibutramine therapy.


BACKGROUND: Medical therapy for thrombosed valve in pregnancy has become an acceptable alternative to surgery, especially in hemodynamically compromised patients.


It seems that the favorable outcome of the potentially fatal pneumonia observed in this patient might be related to early diagnosis, and prompt administration of ganciclovir and standard high-dose immunoglobulins.


Corticosteroids were stopped, and systemic trimethoprim-sulfamethoxazole and topical tobramycin, colistin, chloramphenicol and sulfisoxazole were given.


Eleven patients developed infection requiring hospitalization while taking leflunomide including: lower respiratory tract infections (3), cellulitis (2), disseminated herpes zoster (2), probable TB liver (1), abdominal sepsis (1), mycotic aneurysm (1) and gastroenteritis (1).


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


These microorganisms are recognized as the cause of devastating soft tissue infections, such as cellulitis, myositis, and gas gangrene.


Benign intracranial hypertension should be sought in any young woman complaining of headache during treatment with tetracycline.


Complete regression of iatrogenic Kaposi's sarcoma due to corticosteroid treatment in a patient with tubercular pericarditis.


Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.


Following overdose either agent can affect the central nervous and cardiovascular systems, inducing arrhythmias, conduction disturbances and hypotension.


Because of the potential severity of this interaction, close monitoring of INR and warfarin dosage adjustment is recommended in patients receiving warfarin along with levamisole and 5-FU.


We report two cases that developed acute myeloid leukaemia (AML) during tamoxifen therapy for breast cancer.


Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.


We found that patients with serotonin syndrome most often (74.3%) presented within 24 hours of medication initiation, overdose, or change in dosage.


One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.


This case underscores problems in clinical management with sulfadiazine hypersensitivity, potential immunosuppression from corticosteroids and selection of medications for recurrences of toxoplasmic chorioretinitis.


STUDY DESIGN: Case report.


The strong position taken against narcotic use in Cope's Early Diagnosis of the Acute Abdomen is probably the reason for the perpetuation of the myth of avoiding narcotics for pain relief in patients with undiagnosed acute abdominal conditions.


Their use in women who are pregnant is not without risk to the fetus.


Seven patients presented with refractory bleeding and 1 was diagnosed with severe coagulopathy unresponsive to the conventional treatment.


Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.


ACE-inhibitors-induced metabolic acidosis in a child with nephrotic syndrome.


We describe a novel approach to this rare and complicated problem and provide a review of the literature on the subject.


Video game epilepsy.


However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.


While not life threatening, it can have a severe disruptive effect on the quality of life.


This case suggests that disopyramide should be used with caution in patients with bifascicular block patterns on ECG.


DISCUSSION: These findings suggest that paramyxovirus infection had contributed to the development of DIHS in this patient and that there is a need to seek evidence of other viral infections in some cases of DIHS, especially those without herpes virus reactivation/infection.


When additional indicators of treatment outcome are considered, such as cognitive and occupational and social functioning, it is clear that the overall outcome for schizophrenia is far from satisfactory.


DESIGN: Interventional case reports.


Development of hairy cell leukemia in a patient after cardiac transplantation.


Described here are 2 patients who developed thrombotic microangiopathy of the kidneys after receiving high cumulative doses of the new anticancer drug gemcitabine.


In addition, the response to a corticotropin stimulation test was abnormal, an indication of suppression of the adrenal glands.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Eye movement disorders in bone marrow transplant patients on cyclosporin and ganciclovir.


In the third child, the tics ceased after CBZ discontinuation.


Pentazocine-induced fibrous myopathy and localized neuropathy.


Cotton-wool spots were found in six patients, retinal hemorrhages in four, and branch retinal vein occlusion in one (one eye).


Fatty diarrhea occurred after chemotherapy, probably owing to gland destruction by lymphomatous infiltration.


In November of 2000, the Food and Drug Administration (FDA) requested a voluntary recall of the product from all manufacturers.


An objective causality assessment suggests that the JHR in our patient was probably related to penicillin.


The present report suggests that clarithromycin coadministration induces increased plasma carbamazepine concentrations, which may result in carbamazepine toxicity.


She was treated with neoadjuvant chemotherapy and developed an accelerated SSc syndrome with pericarditis and cardiac tamponade, with lethal results.


Panic attacks occurred for the first time in a patient suffering from delusional depression during treatment with a combination of an antidepressant and a neuroleptic.


The kidney function returned to normal within 1 week.


We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia.


Epidural steroid therapy is a commonly applied "conservative" therapy, but it is not inherently benign.


The abscess aspirate grew mixed organisms including Kluyvera cryocrescens.


Seizures associated with ofloxacin therapy.


This patient developed sequential symptoms including alternative hemiparesis, dysarthria and altered consciousness 5 days after the second course of HD-MTX (8 gm/m2 by 6 h continuous infusion) with leucovorin rescue.


Purple glove syndrome, named for its distinctive purple discoloration and swelling of the hands in the distribution of a glove, is an uncommon complication of intravenous phenytoin administration through small dorsal veins of the hands.


Infectious complications of this therapeutic regime in severe UC are known but to our knowledge a recurrent sepsis complicating this therapy even after cessation of CyA has not been reported in the literature so far.


Complications occurring after manual pumping of the reservoir are rare.


The possible inter-relationship of the cholestatis, central retinal vein thrombosis and immunosuppression are discussed.


The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.


Patients with severe disease and taking combination MTX and corticosteroids are at greatest risk.


A 78-year-old man with a long history of major depression responded well to a course of ECT but relapsed before maintenance treatments could be started.


Recently, problems have arisen regarding infection with P. aeruginosa, which produces metallo-beta-lactamase (MBL) and is resistant to virtually all beta-lactams.


An 8-year-old boy was found to be hypertensive on routine exam (144/88).


NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.


When SASP was changed to 5-aminosalicylic acid (5-ASA), his skin eruptions were resolved, however, he developed weakness and atrophy in his right arm as well as progressive worsening of the dysesthesia in his legs and gait disturbance.


Seizures in patients receiving concomitant antimuscarinics and acetylcholinesterase inhibitor.


The renovascular hypertension in this patient was treated successfully by renal autotransplantation.


Pain was reduced in severity by day 29 and completely resolved once tacrolimus was discontinued on day 42.


This report describes iatrogenic left main thrombosis treated by operative thrombectomy and coronary artery bypass grafting.


As it was so effective in these eyes with resistant CMO, a larger study is warranted to evaluate this form of therapy.


The case demonstrates features of leukostasis which are peculiar to the 'retinoic acid syndrome'.


Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.


We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.


Plasma concentrations of carbamazepine and carbamazepine-10,11-epoxide were measured using high-performance liquid chromatography.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


The clinical setting and diagnostic evaluation suggest multiple mechanisms for the hypersensitivity response.


Etanercept is being tried in patients with congestive heart failure, where TNF-a seems to be increased.


HDR in young children should be restricted to controlled clinical trials until long-term morbidity and efficacy results are obtained from pilot studies.


The patient was taking oral corticosteroids for underlying systemic lupus symptoms, and had classic signs and symptoms of peritonitis.


The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.


BACKGROUND: Magnetocardiography and M-mode fetal echocardiography are non-invasive techniques capable of identifying fetal arrhythmias.


Renal biopsy demonstrated minimal glomerular changes with fusion of podocytes, tubular necrosis with regeneration of tubular epithelial cells, interstitial edema with focal interstitial fibrosis, and interstitial infiltration with neutrophils, eosinophils, plasma cells and mononuclear cells.


Thiotepa and its main metabolite tepa, ultrafilterable platinum, cyclophosphamide and its activated metabolite 4-hydroxycyclophosphamide were determined.


We postulate that pulmonary GVHD and pulmonary infection including aspergillosis played an important role in the occurrence of both PVOD and HUS in our patient.


The infant improved clinically under intravenous hydration therapy, nevertheless lithium serum levels increased again and we did not know for certain if our clinical instinct or the actual figures were correct.


The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.


The cases, as compared with the controls, less frequently showed lipodystrophy (4.4 vs. 65.2%, P<0.001) and hypertriglyceridemia (8.8 vs. 56.5%, P<0.005), whereas the prevalence of subjects with hypercholesterolemia was similar in the two groups (30 and 39.1%, respectively).


Acquired methemoglobinemia: a rare but serious complication.


CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.


We report a case of amiodarone-induced thyrotoxicosis of protracted duration, unresponsive to conventional thionamide therapy, with therapy limited by severe adverse drug reactions.


She had been taking nabumetone for 6 months, but had discontinued the agent 2 weeks before admission due to progressive edema.


The patient was then treated with gemcitabine and irinotecan.


Indinavir-associated nephrolithiasis and chronic interstitial nephritis were the only possible causes identified in this patient.


We describe a case that involves fracture of a stent deployed to nominal pressure.


Calcimimetics are a new class of drugs approved in the European Community and the United States by the Food and Drug Administration that were designed to suppress parathyroid hormone (PTH) levels with a simultaneous reduction in serum calcium and phosphorus levels, and calcium phosphorus product (Ca x P).


Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.


It has a significant effect in relieving motor and vocal tics and in mood and behavior disturbances of children, adolescents, and adults with TS.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.


Further treatment with intravenous ACV led to VZV DNA becoming undetectable in whole blood, a result not achieved with oral valacyclovir.


CONCLUSION: In patients presenting with pelvic masses and a history of IUD placement, actinomycotic infection should be considered and diagnosis attempted by imaging guided needle biopsy.


Seizures in the neonatal period generally respond well to anticonvulsant therapy, but exposure to anticonvulsant medication during the first few months of life may have a detrimental influence on growth and development.


Although porphyria cutanea tarda may be familial, it is more often sporadic in occurrence, and has been associated with excess alcohol ingestion, estrogen administration, iron overload, and several environmental hepatotoxins.


None of these patients met the DSM-IV criteria for a major depressive disorder.


The patient had been experiencing frequent headaches and tenderness at the site of the lump for about a month before being seen by the neurosurgeon.


Here we report a 75-year-old woman with acute left middle cerebral artery occlusion who developed right internal carotid artery occlusion during the last minutes of recombinant tissue plasminogen activator infusion.


Computed Tomography was used to demonstrate the increased retro-orbital fat.


Treatment, mainly steroids and ciclosporin, should be aimed at the control of acute manifestations of cGVHD.


Delayed bowel injury is an infrequently observed complication of chromic phosphate administration.


Treatment of intractable arterial hemorrhage during stereotactic brain biopsy with thrombin.


Possible mechanisms underlying her response to this form of treatment are discussed.


Pneumocystis carinii pneumonia due to corticosteroids.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


Cultures grew Staphylococcus epidermidis, only in liquid (broth) media, in 3 cases; the other 5 showed no growth.


Primary cutaneous coccidioidomycosis was diagnosed.


The present report describes giant atrial thrombi that were treated with thrombolysis in a community hospital.


Lithium neurotoxicity should be considered in Creutzfeldt-Jakob disease differential diagnosis, serial electroencephalograms being the most valuable.


To our knowledge, this is the first reported case of the use of sodium thiosulfate to treat calciphylaxis in a patient with normal renal function.


Conversion of precursor cholecalciferol to the active form of hormone, 1,25-DHCC, requires intermediate hydroxylation by the liver.


Sulprostone, a synthetic prostaglandin with potent uterotonic action, has been shown to have a low complication rate in a large series.


Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.


Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.


Furthermore, patients receiving combined therapy with an ACE inhibitor and a diuretic and patients who experience a cyst hemorrhage while receiving ACE inhibitor therapy are also at risk for reversible renal dysfunction.


Rheumatoid arthritis after 9 years of human immunodeficiency virus infection: possible contribution of tritherapy.


The authors report the case of a 32-year-old man who had been treated for anxiety and obsessive-compulsive disorder and had received 800 mg methylphenobarbital (MPB).


Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.


Ticlopidine treatment was stopped, and a prolonged course of prednisone was necessary to treat the pulmonary and intestinal symptoms.


The additional finding of extensive resorption of the outer cortical surface and bone formation at the inner surface suggested a reversible phase after discontinuation of treatment.


On the next day, she complained of gingival bleeding and purpura again, and her platelet count was 5000/mm3.


Augmentation of aripiprazole with low-dose clozapine.


Cutaneous alternariosis: role of corticosteroid-induced cutaneous fragility.


Death ensued 3 days after the onset of the rash.


Two had positive antihistone antibodies.


Herein we report the successful treatment of invasive aspergillosis with the liposomal amphotericin B (AMB) formulation, Amphotericin B Lipid Complex (ABLC).


Spasm of the sphincter of Oddi is a well-recognized effect of the narcotic class of drugs.


We review the current English language literature on this entity and discuss its clinical features, histology, ultrastructure, etiology, and pathophysiology.


Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.


CONCLUSION: Anterior spinal artery syndrome can occur following retroperitoneal surgery.


The clinical usefulness and possible mechanisms of action of these agents in treating sleep disorder are discussed.


The median latent period was 9.5 hours (range 4 to 24 hours) with a delay to medical consultation of 36 hours (range 6 to 48 hours), and a median serum methanol concentration of 1.4 g/L (range 0.19 to 3.62 g/L).


Analysis of his cerebrospinal fluid showed a decrease in loosely-bound (catalytic) iron and increase in loosely-bound (catalytic) copper, total iron and products of lipid peroxidation, with values approaching normal as the symptoms resolved.


We describe a severe case of hemophagocytic lymphohistiocytosis (HLH), secondary to a candida glabrata retroperitoneal abscess in a 41-year-old simultaneous pancreas-kidney transplantation (SPKT) recipient.


Signs of illness in those that died were vomiting, diarrhea, neutropenia, anorexia, and fever, usually within 3 days of the start of chemotherapy.


A subsequent pathological analysis revealed a mass of hyphae with acute-angle branching, features consistent with Aspergillus, within the cavitary lesion, and she was diagnosed with pulmonary aspergillosis.


Cholestatic liver disease with ductopenia (vanishing bile duct syndrome) after administration of clindamycin and trimethoprim-sulfamethoxazole.


After administration of Oxybutynin concomitantly with an increase in the dose of Dantrolene, she presented the clinical symptoms and laboratory finding of Carbamazepine intoxication.


Because the patient had declined surgery, RFA was chosen for therapy.


Can propofol precipitate pancreatitis in patients with Cushing's syndrome?


Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.


Hypersensitivity to aspirin can be manifested as acute asthma, urticaria and/or angioedema, or a systemic anaphylactoid reaction.


Further findings included bilateral four-finger hands with hypoplastic thumbs and absent radii.


The patient complained of intolerable lumbago and numbness in her buttocks.


These findings suggest that the arterial vasoconstriction decreased the integrity of the intestinal mucosal barrier and permitted the transmural migration of enteric organisms from the lumen of the bowel into the ascites-filled peritoneal cavity.


We report a patient with AIDS and intestinal microsporidiosis.


The evidence suggests that these deaths were the result of causes other than use of the drug.


Relapse-free survival of the responding patients was 24 and 20 months.


We describe a patient who developed NEH on three separate occasions provoked by two different chemotherapeutic agents--cytarabine and mitoxantrone.


A drug lymphocyte stimulation test for salazoslufapyridine was positive, but the patch test was negative.


A review of the literature also reveals that MMF is a safe medication that appears to have a more favorable side effect profile than azathioprine, although it is more expensive than azathioprine.


We believe this to be a previously unreported complication.


Liver biopsy showed extensive ground-glass hepatocytes and extension of thin septum-like fibers from portal tract to the lobule.


This case is remarkable since 1) ECM developed after subcutaneous and not after intramuscular injection, 2) the injection was given by the patient himself, and 3) glatiramer acetate can induce skin necrosis as a side effect.


Neuropathic pain syndrome as an occult manifestation of injury of the spinal cord after surgical repair of aortic coarctation.


Removal of a well-fixed metal-metal hip resurfacing acetabular component.


The authors suggest that alprazolam may have enhanced specificity for a subpopulation of benzodiazepine receptors.


Patient B continued at 80% of standard dose (2000 mg/m2) and symptoms resolved without further intervention.


The abnormalities in her liver function tests included a progressive rise in bilirubin level over five weeks.


Prolonged echoviral meningitis in a cancer patient with normal serum immunoglobulins.


This case study highlights the strategy of appropriate and timely surgical management.


Stopping the topical steroids with concurrent lowering of the IOP resulted in improvement in the uncorrected and best corrected visual acuities and was associated with resolution of the corneal findings.


Of 371 patients treated with 8MOP, three (0.8%) developed an acute dermatitis in the PUVA-treated areas.


Skin tests with methotrexate were not performed because their diagnostic value is controversial.


Information on medical history was obtained from their carers and hospital records.


All 5 patients were also taking -corticosteroids.


CONCLUSIONS: Clinicians should be aware that Crohn's disease is a potential novel adverse drug effect of Copaxone.


We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).


These two cases demonstrate the importance of early treatment including dantrolene.


Thalidomide as elective treatment in persistent erythema multiforme; report of two cases.


Anterior chamber shallowing was noted in both patients at presentation.


There is likely to be increasing pressure on pediatricians and other health professionals to prescribe HBO(2).


It has shown efficacy in patients with B-cell non-Hodgkin lymphoma and also in CD20-positive Hodgkin lymphoma.


The authors discuss the implications of these findings.


These findings suggest that there may be a place for intravenous CyA therapy in patients with severe Crohn's disease who do not respond to conventional therapy or to oral treatment with CyA.


We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).


However, such a drug-induced mixed pattern of lichen planus pemphigoides with pemphigus-like features has never been reported.


Fludarabine induced lung toxicity must be considered in all patients who develop unexplained lung disease while receiving fludarabine.


This occurred after the first cycle of cisplatin and then again after the second cycle.


An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.


After disulfiram therapy was discontinued, symptoms subsided and results of liver function tests returned to normal.


Aripiprazole-induced hiccups: a case report.


We report the case of a 59-year-old man who was treated with intraarterial chemotherapy for metastatic colonic adenocarcinoma.


This appears to be the first such report in the literature.


Laboratory studies were notable for hypothyroidism.


Streptomycin caused vertigo and had to be stopped.


The association with prolonged unopposed estrogen-like stimulation with tamoxifen as a possible factor in the development of ovarian endometrioid carcinoma is discussed.


The mechanism remains unclear.


RESULT: Additional investigation revealed duodenal villous atrophy and positivity for anti-endomysium and anti-gliadin antibodies.


The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.


A punch biopsy showed the presence of KS, whereas a polymerase chain reaction assay documented the presence of human herpes virus type 8 (HHV8) DNA in the skin lesion.


Although it has been reported that emboli from atherosclerotic disease may be more frequent than commonly appreciated, hepatic infarction caused by an arterial embolus is an unusual but serious complication.


Fifty-two mental hospital cases of acute and chronic schizophrenia and gross behaviour disorders were investigated and observed for 6-12 months during treatment with clozapine.


Transient neurological disturbances induced by the chemotherapy of high-dose methotrexate for osteogenic sarcoma.


Myoclonic movements were noted when the patient arrived at the outpatient infusion center to begin his intermittent dobutamine infusion, and he was sent to the emergency department, where he was treated with calcium gluconate, regular insulin, and lorazepam and was instructed to stop his potassium supplements; he then received his dobutamine infusion.


Because the combination of bleomycin and vinca alkaloids is commonly used for the treatment of AIDS-related Kaposi's sarcoma, clinicians should be aware of the risk of provoking acral necrosis in patients who develop Raynaud's phenomenon under chemotherapy.


Early discontinuation of anticonvulsants after neonatal seizures: a preliminary report.


To our knowledge, this is the second such case reported, as Merkel cell carcinoma most commonly occurs after kidney and heart transplants.


This report describes the management of repetitive paroxysms of supraventricular tachyarrhythmias triggered by catheter manipulation during interventional procedures in two children.


OBJECTIVE: The purpose of the study is to investigate the relationship between inhaled or intranasal adrenergic agonists and corticosteroids and the development of central serous chorioretinopathy (CSC).


We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.


The American Society for Regional Anesthesia and Pain Medicine has specific guidelines for treatment of these patients when they undergo neuraxial anesthetic procedures.


True allergy to mercury is rare but is more common in females.


This delivery system, however, carries with it an intrinsic morbidity warranting attention in the often prolonged chemotherapy regimens demanded by cancer patients.


Extensive visual loss with topical facial steroids.


In addition, IVIG may effectively modulate the overreactive immune system in AHS.


She admitted that she often induced the episode herself and derived pleasure out of it.


The first therapeutic schedule included rifampicin, isoniazid and ethambutol; no uniform treatment could be used for these patients.


It was not accompanied by clinical hallmarks of hypersensitivity, which is suggestive for metabolic rather than for immunoallergic idiosyncrasy.


All patients had taken phenytoin for variable time periods (range 16-80 days; mean: 40) and were on the medication when the skin lesions first appeared.


Both analyses confirmed that the isolated material is calcium carbonate.


Parenterally administered biperiden proved to be highly effective in the control of the symptoms.


We conclude that the use of hemopoietic colony stimulating factors might be a suitable means to achieve the correction of severe thionamide-induced hematologic adverse reactions.


The patient also developed red cell alloantibodies that produced a delayed hemolytic transfusion reaction (DHTR) and broad HLA antibodies.


METHODS: Each patient received a 10 unit/m2 dose of bleomycin administered intravenously at 1 to 1.5 units/minute.


Monocytic leukemoid reaction, glucocorticoid therapy, and myelodysplastic syndrome.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


More recently, extrapyramidal side effects have gained importance because they are significant factors in both the patient's acceptance of the particular drug and his or her social adjustment.


Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.


The striking temporal relationship between commencing dalteparin on day 1 and subsequent development of effusion on day 4, following 3 doses of LMWH, led us to believe that the bleed occurred as a result of the therapy.


ENT surgeons, general physicians, and infertility experts should consider this in the differential diagnosis of neck swellings, particularly after OHSS and IVF treatment, and in this case report, we emphasis the need for an urgent ultrasound of the neck in such patients.


Zonisamide is a broad-spectrum antiepileptic drug used to treat various types of seizures.


Discontinuation of the Osmolite resulted in a prompt prolongation of the prothrombin time.


Additional history disclosed that the patient had been given metamizole for pain before onset of his illness.


Liver biopsy showed cholestasis with both cytological and architectural alterations of interlobular bile ducts.


CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.


Reversal of post-reperfusion coagulopathy by protamine sulphate in orthotopic liver transplantation.


INTRODUCTION: We describe the neurointensive care (NIC) management of a patient with severe cerebral swelling and raised intracranial pressure (ICP) after severe sodium valproic acid (VPA) intoxication.


Quetiapine and obsessive-compulsive symptoms (OCS): case report and review of atypical antipsychotic-induced OCS.


Thiabendazole is a relatively safe and effective agent with a wide range of activity against nematodes infesting the gastrointestinal tract.


This is an unusual association, and to date only seven cases have been reported.


OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.


Cidofovir is an antiviral agent that demonstrates in vitro activity against murine polyomavirus and has been proposed for treatment of BKVN in renal allograft recipients.


Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma.


Amphojeloma: antacid impaction in a critically ill patient.


Most of these cases have been associated with the administration of chemotherapy or radiotherapy for CLL, suggesting that the former may be a secondary leukemia.


Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.


This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.


A 45-year-old man presented with deep vein thrombosis of the right leg and bilateral pulmonary embolism.


Lansoprazole was discontinued, and the platelet count returned to normal.


Cerebral air embolism after intrathoracic anti-cancer drug administration.


Zolpidem (Ambien), a relatively new nonbenzodiazepine sedative-hypnotic, was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia.


Successful treatment of aortic thrombosis after umbilical catheterization with tissue plasminogen activator.


Initial treatment including removal of the catheter and antibiotic therapy was unsuccessful and both patients had persistent fever and bacteremia.


Death ensued after three days due to cerebral edema with herniation.


CONCLUSION: We review the literature of reported cases of primary osteogenic sarcomas of the skull to discuss the common clinical presentation, evaluation methods, and recommended treatment plans.


In the present study, our cases suggested that patients receiving a high dose of co-trimoxazole should be evaluated for these potential complications during a course of treatment, particularly in elderly patients with preexisting renal dysfunction.


These cases were compared with those attributed to anthracyclines and taxanes.


The patient presented unfavorable evolution with progressive worsening of respiratory function, hypotension, and renal failure.


Some patients received antilymphocyte globulin (OKT3), when acute rejection was imminent.


The aim of our paper was to describe hepatotoxicity of sirolimus (SRL) in a kidney graft recipient.


6. The wide variety of drugs associated with this complication suggests that any cytotoxic agent may be leukemogenic.


An acute viral illness or reactivation of systemic lupus erythematosus were the suspected diagnoses.


The patient's second acceleration occurred 22 months after the CML diagnosis.


A female patient with HER2 positive, metastatic breast cancer presented with pulmonary infiltrates, and a plural effusion dyspnoea after several months of trastuzumab treatment.


Acute chest pain is a common presentation in emergency.


Differences in interpretation by patients and healthcare professionals may cause the observed disparities in seriousness and outcome of reported ADRs.


CONCLUSIONS: Topical imiquimod 5% cream seems to be a useful treatment for eyelid nodular basal cell carcinoma in selected cases, but further long-term studies are needed to assess the efficacy and safety of this approach.


The patient received hyperbaric oxygen therapy for 1 week.


The most commonly cited cause of drug-induced IHA has been receipt of second and third generation cephalosporin antibiotics.


Syncytial giant cell hepatitis recurred after transplantation and was efficiently treated with ribavirin.


Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.


It has been shown to possess beneficial effects in reducing the relapse rate in relapsing-remitting multiple sclerosis.


Blood, urine, and sputum cultures were positive for Trichosporon.


Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.


Acute pancreatitis in a child with idiopathic ulcerative colitis on long-term 5-aminosalicylic acid therapy.


METHODS: An extensive review of the English medical literature through the National Library of Medicine (PUBMED) was performed to identify patients who had received or continued to receive radiation therapy while on phenytoin.


A variety of movement disorders are known to occur in association with carbamazepine (CBZ) therapy in adults and children, but development of tics has been described infrequently and only in patients with underlying Tourette's syndrome or other movement disorders.


Among 12 thyrotoxic patients, a patient with arrhythmogenic right ventricular dysplasia, who had been taking amiodarone for 4 years, developed thyrotoxicosis with subacute onset, accompanied by transiently positive thyrotropin (TSH) receptor antibody (TRAb), or thyrotropin-binding inhibiting immunoglobulin (TBII).


We describe a 28-year-old man who was brought to the emergency department with a new-onset seizure and clinical signs and symptoms consistent with advanced delirium tremens.


A T9-10 epidural catheter was placed prior to induction of general anaesthesia.


Calciphylaxis (calcific uremic arteriolopathy) is a severe complication of hemodialysis characterized by subcutaneous calcification of the small arteries and tissue necrosis.


Investigations did not reveal associated infection or an underlying immunological disorder; however, the patient admitted to excessive use of topical anesthetic eyedrops in the post-LASEK period.


In one patient, disease was confined to the colon, while three patients had disease involving the terminal ileum and colon.


Visual loss after a single small dose of vincristine has never been reported.


Four cats had a history of difficulty in regulating the diabetic state.


Motor cortex excitability was studied by single and paired TMS and MEPs were recorded from FDI.


After intravitreal injection of triamcinolone acetonide, cataract may rapidly develop in eyes that have been intensively treated, topically and systemically, by corticosteroids for several years.


The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.


Survival of patients with AL amyloidosis is no more than 1 to 2 years from the time of diagnosis with current management approaches.


Although immunosuppressive medications were rapidly tapered, neither patient could receive potentially curative therapy with unmanipulated donor-derived lymphocyte infusions (DLI) because of the substantial risk of severe GVHD.


In this article, four patient reports of a specific interaction--the serotonin syndrome--are presented.


These patients may develop systemic sepsis through bacterial or fungal translocation across the intestinal wall.


We examined and treated six patients with acanthamoeba keratitis associated with contact lens wear from 1981 to 1988.


Heparin was given for 15 hours after stenting, and aspirin and ticlopidine medication were continued.


It is mainly adolescents who are experimenting with these plants.


Isotretinoin, a drug used for the treatment of acne, has been shown to have teratogenic effects.


Physical examination showed proximal muscle weakness in his arms and legs.


CASE SUMMARY: A 57-year-old female suffered from osteomyelitis of the left humerus, with a white blood cell (WBC) count of 2.8 x 10(3)/mm3 and absolute neutrophil count (ANC) of 0.28 x 10(3)/mm3, occurring after 24 days of vancomycin therapy.


Following administration of 0.1 mmol/kg of gadodiamide to a patient with end-stage renal disease, the serum clearance of this contrast agent by automated PD was examined.


METHODS: A retrospective study in an institutional practice.


Brain computed tomography disclosed bilateral temporal hypodensity with edema.


OBJECTIVE: To discuss the various diagnostic and treatment options that should be considered when managing parotid duct injuries that result from skin cancer extirpation.


Studies of porphyrin metabolism in patients treated with cyclophosphamide may help to elucidate this possibility.


The resultant renal failure and fluid overload necessitated peritoneal dialysis.


Unexplained menorrhagia and hematuria: a case report of Munchausen's syndrome by proxy.


Examination of bone marrow at the last clinical follow up demonstrated both acute myeloid leukemia and residual metastatic Ewing sarcoma.


Alteration in carbohydrate metabolism, such as transient glucose intolerance at the start of therapy in non-diabetic acromegalic patients, and increased sensitivity to insulin or oral hypoglycemic agents in diabetic acromegalic patients, is common.


Rapid improvement of delusional depression following drug-induced seizures: case report.


These findings did not correlate with changes in serum IgG, IgA, IgM, IgD, IgE or alpha 2-macroglobulin.


Rapid onset of muscle weakness (rhabdomyolysis) associated with the combined use of simvastatin and colchicine.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


RESULTS: We measured the highest acyclovir serum levels reported so far (229.9 mumol/L = 51.8 mg/L).


His fever resolved and clearance of the nodule was documented on a CT scan 2 months after diagnosis and initiation of treatment.


Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.


When fentanyl was subsequently administered to treat her pain, the stridor resolved.


RESULTS: Scouting biopsies demonstrated multiple comedones and ruptured epidermoid cysts.


The number of melanosomes, mitochondria, endoplasmic reticulum and dendrites were increased.


Sudden sensorineural hearing loss has rarely been reported as a result of NSAID use.


We describe a patient in whom this interaction caused a series of dangerous clinical events.


In two cases acute renal failure also occurred.


Here we report our experience with three of these patients, who experienced progressive disease after a variety of previous therapies, including prior immunotherapies, and who achieved good outcomes with ipilimumab.


Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.


Autoimmune hemolytic anemia associated with postirradiation malignant stromal tumor (leiomyosarcoma) of the jejunum.


Three (10%) eyes had an epithelial defect, nine (31%) had iridocyclitis, and seven (24%) had associated secondary glaucoma.


Two underwent shunt revision for proximal obstruction, with an intact distal system.


A 32 year old man with chronic severe asthma, requiring maintenance oral corticosteroids, was started on a weekly dose of methotrexate.


In contrast, the LMW heparinoid Org 10172 (Organon, Oss, The Netherlands) did not cause platelet activation.


However, a Jarisch-Herxheimer reaction occurring in a patient receiving treatment for ocular syphilis can be serious, resulting in the rapid loss of vision.


This report describes the development of multiple-site, biopsy-proven osteonecrosis in a patient with small-cell bronchogenic carcinoma who had received chemotherapy and short-term administration of corticosteroid.


Pathological features such as large amounts of lipid droplets and lysosome-melanosome complexes were also found within the melanocytes.


Prompt diagnosis and surgery offer excellent chances of surviving this fatal condition.


She received an accidental 450-mg bolus injection of morphine intrathecally and developed hypertension, status epilepticus, intracerebral hemorrhage, and respiratory failure.


The prevalence of TD was 3.96% (4/101).


The withdrawal of PI was followed by a complete improvement of renal function.


This report emphasises the clinicopathological features and the diagnostic peculiarities of the acute tumour lysis syndrome, which occurs uncommonly in dogs.


Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a primary lymphoproliferative T-cell disorder, currently classified as a peripheral T-cell non-Hodgkin's lymphoma.


This appears to cause immediate regression of the neovascular frond and allows time for the laser, which is applied subsequently to have its effect.


Acute renal failure during lisinopril and losartan therapy for proteinuria.


An increase in exercise capacity was reported by 78% of patients; objective measurements showed that the mean value of VO2max in a subgroup of 11 patients increased by 50% after treatment.


Symptoms correlated with an increase in alkaline phosphatase and with bone scintigraphy findings.


INH, which is a leading cause of drug eruptions in the above group of drugs was withdrawn.


Growth hormone deficiency (GHD) results in salt and water depletion and studies confirm that replacement leads to sodium and vasopressin-mediated water retention in patients with intact posterior pituitary function.


A biopsy specimen showed pleural and parenchymal fibrosis.


Magnetic resonance imaging showed several areas of abnormally high signal on T2-weighted images in the brainstem, thalamus, and mamillary bodies.


Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.


Both 6-MP and AZA are widely used and are known to cause hepatotoxicity in a proportion of patients.


Patients with metastatic breast adenocarcinoma showed complete responses in both treated nodules after ECT.


He developed a late secondary infection in some sites treated with imiquimod.


Foscarnet resistance and cidofovir resistance have also been described, but no previous reports have suggested treatment regimens for patients with CMV refractory to all three of these drugs.


However, it is still produced and marketed in several countries in Central and South America as well as in Europe, Asia, and Africa.


Thereafter, the patient's renal function slowly worsened and she started chronic hemodialysis 5 years later.


Physical findings and urine output were normal, except for increasing blood urea nitrogen (BUN), serum creatinine and mild proteinuria.


Our observation would confirm this statement.


Our second patient had a 2-year history of asthma prior to the onset of rippling muscles which preceded the myasthenic symptoms by 4-8 weeks.


The patient suffered no side effects, and use of G-CSF represents an important addition to the management of a life-threatening drug reaction.


Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.


If a strong clinical likelihood of local disseminated intravascular coagulation exists, then In-111 platelets may be valuable in localizing the focus of platelet consumption.


However, spontaneous degenerative rupture of the plantar fascia is not well documented in the literature.


Phantom limb pain as a manifestation of paclitaxel neurotoxicity.


Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.


One patient has a resistance-related mutation (M460I); the major risk factor for emergence of resistance in this patient was the presence of early and persistent antigenaemia.


The nephrotic syndrome was treated successfully with prednisolone.


New therapeutic approaches should be explored.


It is suggested that special precautionary measures should be taken regarding the dose and the route while administering epinephrine to avoid mishaps.


L. monocytogenes infection should therefore be considered in CAPD patients with gram-positive rod peritonitis, even if immunocompetence is presumed.


Occult quinine-induced thrombocytopenia.


The importance of high-tone audiometry in monitoring for ototoxicity.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


Given that discontinuation of nitrofurantoin and introduction of methylprednisolon therapy significantly lowered liver enzyme levels, restoring most of them to normal, we concluded that this was probably the case of toxic liver damage caused by nitrofurantoin.


We describe a 51-year-old woman with sacroiliitis following a fall.


Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation.


Lymph node biopsy showed almost complete effacement of the nodal architecture with diffuse proliferation of small vessels forming an arborizing network, surrounded by atypical lymphocytes, usually CD3+ CD4+ and occasionally CD3+ CD8+.


We report a protocol in which anticonvulsant agents are discontinued before discharge from our neonatal unit.


Successful treatment of refractory immune hemolysis following unrelated cord blood transplant with Campath-1H.


A 59-year-old female was admitted to Tsukuba University Hospital and diagnosed as IgA-lambda multiple myeloma (stage IIIA).


Coincident with the preeclampsia was a postdural puncture headache complicating the diagnosis of late postpartum preeclampsia.


OBJECTIVE: To propose a new hypothesis regarding the possible role of glucocorticoid excess in patients with an extended acute illness, based on a patient's presentation and therapy in a critical care situation.


Prazosin-induced first-dose phenomenon possibly associated with hemorrhagic stroke: a report of three cases.


Moreover, applying the Cockcroft-Gault equation to obese patients leads to an overprediction of creatinine clearance and, when used in the Calvert equation, consequently to a carboplatin dose that is too high.


Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.


The patient has received follow-up treatment for three years and five months without local or systemic effects observed.


All 3 had documented CBZ blood levels in the therapeutic range at the time, and none had other symptoms or signs of clinical intoxication.


Drug-induced hypersensitivity syndrome associated with a marked increase in anti-paramyxovirus antibody titers in a scleroderma patient.


Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9.


Although the development of posterior subcapsular cataracts is a known complication of systemic steroid therapy, it usually occurs after several years of chronic administration.


Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.


He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.


The use of adenosine has been suggested as a diagnostic tool in the evaluation of wide ORS complex tachycardia.


CASE SUMMARY: A 72-year-old white woman was treated with sertraline for depression for 18 months and was then admitted to the hospital with a fractured tibia.


Three of the patients had the carcinoid syndrome and one a renal carcinoma, and all were treated with interferon-alpha 2b or 2a (IFN-alpha 2b, 2a) with doses ranging from 1.5 x 10(6) U daily to 18 x 10(6) U three times weekly.


Nephrogenic diabetes insipidus and renal tubular acidosis secondary to foscarnet therapy.


On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.


An extensive MEDLINE search located 22 other reports of patients who developed HDAs, sometimes associated with thrombosis, but whose platelet counts did not decrease.


A liver biopsy revealed chronic hepatitis with bridging fibrosis and piecemeal necrosis.


One of the patients presented hyperprolactinemia and a raised estrogen/androgen ratio but the hormone levels were not raised in the other.


On the first occasion she experienced arterial fibrillation secondary to a severe episode of hypotension following local anaesthesia, while on a course of beta-blockers.


These organisms have occasionally been reported as a cause of serious infections in man but have not been reported as a cause of shunt infection.


Three prepubertal children who suffered severe, incapacitating anxiety disorders with panic-like symptoms were treated successfully with clonazepam.


Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after lung transplantation, for which several risk factors including pretransplant seronegativity for Epstein-Barr virus are known.


We present this report to alert physicians and pharmacists about the potential risk of the first-dose phenomenon even at the recommended initial doses of prazosin in hypertensive patients who have suffered a recent stroke.


A review of the literature disclosed 8 cases of this association with a fatal fulminant outcome in 5 cases.


Expandable metallic stents have been used effectively to treat multiple nonsurgical esophageal conditions.


In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.


It should be recognized that ibuprofen may be associated with salt and water retention in the same fashion as previously described with phenylbutazone and indomethacin.


Therefore, we concluded that this patient's pulmonary disease was caused by calcium stearate, an additive for an antihistaminic drug.


In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.


One patient presented twice with seizures.


METHODS: This is a case of angiosarcoma developing 5 years after curative therapy for T3N0 squamous cell carcinoma of the supraglottic larynx.


Electroencephalography (EEG) with polygraphic recording revealed tonic status epilepticus.


Management with intravenous magnesium sulfate.


Fluoxetine is a relatively new antidepressant, reported to have minimal side-effects.


Although the symptom complex of disseminated cysticercosis has been well recognized for over half a century, it is not clearly included in recent disease classifications.


Exuberant molluscum contagiosum as a manifestation of the immune reconstitution inflammatory syndrome.


The infants were treated with oral propranolol.


The clinical manifestations, characteristic radiologic images, treatment outcome, and possible mechanisms of this late complication are presented.


As the treatment of calciphylaxis is mainly empirical and controversial, we decided to administer cinacalcet with paricalcitol for the control of hyperparathyroidism and sodium thiosulfate to improve the calcification of the arterioles.


After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.


Psoralen-ultra violet A (PUVA) photochemotherapy can be effective, but frequent maintenance therapy may be required to prevent relapse of symptoms.


The child, at present 15 months old, has had to undergo two operations for fronto-orbital advancement because of insufficient growth of the mid-face, nasal airway hypoplasia and increased intracranial pressure.


A full vasculitis screen was negative.


Obtaining appropriate cultures can be critical in making the diagnosis and directing treatment.


Seizure activity is a known complication associated with multiple sclerosis; however, it may also result from side effects of the treatments for the disease.


The patient developed flares of vasculitis symptoms associated with rises in either type of ANCA.


Specific antiinfectious therapy together with cyclosporine and dexamethasone may be a therapeutic approach.


Dermatologists need to be aware of this potential serious reaction to this phenobarbital-containing therapy for hot flashes.


A hemogram indicated an inflammatory leukogram and a regenerative anemia with spherocytosis and thrombocytosis.


Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.


Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.


Histologic examination of biopsies from two regressing tumor nodes showed necrotic tumor cells and infiltration with CD8 positive cells.


Herein, in addition to a comprehensive literature review of this entity, three additional patients are presented.


Monitoring blood concentrations of tacrolimus is vital, and appropriate dosage adjustments are required when the two drugs are administered concurrently to avoid serious interactions such as nephrotoxicity and neurotoxicity.


Consequently, this is a likely, although rare, possible adverse effect with propafenone for which patients should be monitored.


Psychotic disorder associated with isoniazid.


She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.


Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.


Serial computed tomographic scans of the brain disclosed this uncommon phenomenon.


Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.


Effectiveness of spray application of ACNU in the local control of malignant gliomas: report of two cases.


Recurrent portopulmonary hypertension after liver transplantation: management with epoprostenol and resolution after retransplantation.


The diagnosis of C. difficile was confirmed by a stool-cytotoxin test and endoscopic examination.


The availability of atypical antipsychotic agents represents a significant step forward for those patients who are nonresponsive to conventional antipsychotics, offering proven efficacy, a lower risk of extrapyramidal symptoms, and improved clinical outcomes.


Infliximab therapy may cause a lupus-like syndrome that is reversible upon discontinuing this agent.


Initial visual acuity was <20/800 (finger counting at 1-2 feet) with retinal edema on fundoscopy, arterial pH 7.19, methanol 97 mg/dL (30 mmol/L), formate 14.3 mmol/L, and ethanol undetectable.


Our experience reveals that patients who do not have heart failure or do not use insulin also can develop moderate-to-severe edema that necessitates discontinuation of the thiazolidinedione.


Consequently, it is most appropriate to explain the possible side effects from misuse of lindane to each patient.


CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.


In two cases of chronic schizophrenia complicated by diabetes mellitus, the concomitant use of the neuroleptica and oral antidiabetics was attended by the appearance of symptoms simulative of syndrome malin, i.e. hyperpyrexia, tachycardia, blood pressure instability, disturbances of consciousness, muscle rigidity, tremor, dysphagia, salivation and urinary incontinence.


During application, the patient complained of burning sensation of vagina and vulva.


Only two case reports of adults with allergic contact dermatitis to this chemical exist in the literature, and we describe three more cases of children with recalcitrant atopic dermatitis found to have potential allergic contact dermatitis to bisabolol- a component of the Aquaphor emollient they were using to treat their atopic dermatitis.


Conversely, when rheumatoid arthritis (RA) is seen in association with HIV infection, remission of RA has been observed in some cases.


Falsely raised TSH levels due to human anti-mouse antibody interfering with thyrotropin assay.


Removal of the deposit ended the corneal erosion and returned visual acuity to normal.


Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.


Heparin-associated thrombocytopenia and thrombosis is a severe complication of systemic heparin therapy.


We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman.


To replace or not to replace? - Partial coning and a sixth nerve palsy secondary due to displacement of a tunnelled intrathecal catheter for pain control.


Resolution of symptoms, physical signs and radiographic changes followed drug withdrawal and steroid therapy.


MCC seems to be common in transplant recipients and 52 cases have been reported in the literature.


Pilocarpine has been used as an ophthalmologic agent for decades; however, toxicity rarely has been reported in the medical literature.


Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.


These features have not been previously associated with infliximab or leflunomide therapy and represent a unique cutaneous hypersensitivity reaction that does not fit any known description of an immune-mediated hypersensitivity reaction.


Common manifestations of toxicity, like confusion and ataxia, are well known.


Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.


A recommendation to add corticosteroids to serotonin receptor antagonists only after demonstrated nausea in chemotherapy regimes with low-dose cisplatin (20 mg/m2) for five days seems justified.


In contrast, our observation suggests that these substances may also display unexpected proconvulsant effects in vivo.


She was diagnosed to have pulmonary sarcoidosis at stage II, and the combination treatment was discontinued.


The endoscopic and histological features were consistent with the diagnosis of ischaemic colitis.


Although it is related to numerous risk factors, its etiology remains unclear.


CONCLUSION: One injection of intravitreal triamcinolone was an effective short-term treatment for resistant CMO in uveitis.


Since fondaparinux use in patients undergoing PCI has been associated with an increased risk for catheter-related thrombosis, the use of fondaparinux in PCI patients should be limited.


DATA SOURCES: Published scientific papers, review articles, book chapters, and clinical experiences.


A breast cancer patient with pelvic and gastric malignancy after adjuvant tamoxifen treatment for breast cancer.


A notable improvement in cancer symptoms and reduction in tumor size were seen in all three patients.


Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.


This article reports the case of an otherwise healthy patient who experienced permanent sensorineural hearing loss after a brief course of naproxen and reviews the literature on NSAID-related permanent sensorineural hearing loss.


Parkinsonian features were progressive, even after the patients had stopped work.


A case is reported of a metastatic gestational choriocarcinoma in a 25-year old woman.


Anterior ischemic optic neuropathy secondary to interferon alfa.


When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.


The author describes six cases in which gabapentin treatment reduced the frequency of hot flashes.


It is essential that perioperative physicians, especially anesthesiologists, understand the risk factors, clinical scenario, and treatment of SS.


A group of six patients, three with malignant melanoma, two with basal cell carcinoma, and one with metastatic adenocarcinoma, were enrolled in the study.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


The serum concentration of cerivastatin showed that the half-life of cerivastatin in this patient was 22.4 h, compared with 2.4 h for normal controls.


Complex drug-induced cutaneous reactions have been previously reported with other drugs, especially with D-penicillamine, which bears chemical similarities with captopril.


Leishmaniasis is an emerging disease in HIV-infected persons; visceral leishmaniasis is an AIDS-defining opportunistic infection.


The mother had received carbamazepine therapy for epilepsy.


Continuing studies are required, particularly to clarify the possibility of long-term developmental defects.


Nerve biopsies confirmed the presence of Mycobacterium leprae in both endoneurial and perineurial areas, mainly in foamy macrophages (Virchow cells), but there were also large accumulations of an amorphous, acid-fast and alcohol-fast material which was not obviously of bacterial origin.


Cholestyramine was utilized to interrupt the enterohepatic recycling of warfarin and for its antidiarrheal effects to prevent gastrointestinal vitamin K wasting.


He and his wife had been examined and treated as an infertile couple for 3 years.


Six days after discontinuation of the drug, central nervous system symptoms had resolved, and, 4 days later, renal function returned to pretreatment values.


His atrial fibrillation subsequently had converted to normal sinus rhythm while he received propafenone without adverse effects prior to this episode.


Another trial of slower desensitization was done using Pancrease MT 16 (1 capsule: 16 000 U of lipase, 48 000 U of amylase, and 48 000 U of protease), starting with 1/4 capsule per day, with increments of 1/4 capsule every 3 days, until an entire capsule was reached by day 10, then increased by approximately 1/2 capsule every 4 days until reaching the therapeutic dose of 1 capsule with each meal by day 25.


We conclude that a combination of cytokines may be useful in treating relapsed leukemia after BMT.


The course of delirium due to lithium intoxication.


Propranolol-induced hypertension in treatment of cocaine intoxication.


A patient with ocular syphilis is presented.


Continuous supplecation of calcium and vitamin D, provoked dehydration and the mechanism of the milk-alkali syndrome also contributed to this extremely high calcium level.


Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.


Delayed hypersensitivity to flurbiprofen.


The source of these L. monocytogenes infections was not found.


The patient recovered motor, sensory, and bowel and bladder function over the next 48 h.


The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.


The clinical aspect closely resembled classical transient global amnesia but the episode after clioquinol lasted longer (24 hours to three days) and a more or less extensive retrograde amnesia persisted permanently.


Higher MK-0457 dose levels were associated with clinical responses and down-regulation of CrkL phosphorylation in leukemia cells.


Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.


The patient underwent coronary stenting without any immediate signs of complications.


A 63-year-old man with a T1c adenocarcinoma of the prostate, Gleason score of 7 (4+3), and a pretreatment prostate-specific antigen (PSA) level of 9.5 ng/mL was treated with external-beam radiation therapy (45 Gy) and 2 magnetic resonance imaging-guided high-dose rate brachytherapy boosts (10 Gy each.) The patient also received neoadjuvant, concurrent, and adjuvant hormonal treatment with leuprolide for 7 months total.


Complications of tumour overkill when associated with high dose methotrexate therapy.


Temporal sequence of his signs and symptoms after each administration of tobramycin (similar to re-challenge testing), and his improvement after discontinuation of the drug strongly suggest an adverse drug reaction.


CONCLUSION: Oral mucositis is a frequent and potentially severe complication of cancer chemotherapy.


These adverse reactions were recognized early and the appropriate treatment of agranulocytosis resulted in complete recovery in both cases.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


Benign thymic hyperplasia after chemotherapy for acute myeloid leukemia.


Treatment of silastic catheter-induced central vein septic thrombophlebitis.


Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.


This report presents a patient with membranoproliferative glomerulonephritis (MPGN) who developed KS following treatment with long-term medium dose glucocorticoid and short-term additional immunosuppressives.


Recent technical advances in infusion systems in the form of the infusaid pump has allowed delivery of chemotherapeutic agents to the liver with great reliability.


Although adverse effects are mainly mild, more serious infrequent adverse effects including leucopenia are mentioned.


One and a half years later, she is still alive and well, on interferon for persisting myeloma.


CONCLUSIONS: Capecitabine and 5-fluorouracil (5-FU) are known vasospasm inducers.


The first case had cytogenetic changes in the bone marrow suggestive of therapy-associated leukemia, and the second developed myelodysplastic syndrome on therapy which was likely chemotherapy-induced and led to acute leukemia.


A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.


One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.


Acute generalized exanthematous pustulosis induced by nimesulide.


Several patients successfully treated with halofantrine without any treatment failure have also been documented in Japan.


Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.


This patient did not initially receive surgical debridement and systemic antibiotics, the standard treatment for necrotizing fasciitis of bacterial origin.


The diagnosis was confirmed by immunofluorescent studies.


He received systemic chemotherapy twice and in both instances developed disseminated intravascular coagulopathy (DIC), accompanied by acute decrements of the peripheral platelet count and plasma fibrinogen, an increment of the fibrin degradation products (FDP), and bleeding tendency with the appearance of skin purpura.


These symptoms resolved but recurred rapidly (within 24 h) and were more debilitating following a second exposure to the same antibiotics at the same doses 8 months later when the patient was readmitted for treatment of another cystic fibrosis-related pulmonary exacerbation.


Incomplete posterior hyaloid detachment after intravitreal pegaptanib injection in diabetic macular edema.


The conglomerate of plastic threads, entrapped food material and other debris, formed a huge mass occupying the whole stomach.


Bronchoscopy revealed diffuse erythema without bleeding.


Nonsteroidal antiinflammatory drugs can cause oral ulcers.


The case of a patient with apparent cocaine toxicity and drug-mediated hypertension and tachycardia is presented.


As a possible mechanism, a competitive inhibition at the receptor site of female hormones involved in water regulation is suspected.


The male patient was treated with 225-mg/day clozapine and the time to the diagnosis of agranulocytosis was 6 weeks.


Vortex keratopathy associated with atovaquone.


After several unrevealing medical work-ups, he was found to have a high blood lead level (122 microg/dL); he has a history of scraping and sanding lead paint without adequate protective measures.


A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy.


No subjective discomfort was reported.


Ultrasound-guided block may improve patient safety by avoiding the soft tissue structures in the needle path that can't be readily seen by fluoroscopy.


Rhabdomyolysis following clarithromycin monotherapy.


Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.


Without other causes for the hyponatremia, she was diagnosed with the syndrome of inappropriate antidiuretic hormone, presumably caused by desmopressin.


Immunohistological studies showed that these cells were positive for CD30 and CD79a, but not for CD15 or CD20.


Hypertension was found to be the most significant risk factor for developing retinopathy.


Both patients were then treated with a carboplatin alternative to cisplatin in the following courses, which resulted in neither a relapse of the colitis nor a recurrence of the malignancies up to this time.


In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.


CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.


Choline magnesium trisalicylate was discontinued after eight days and the patient's LFT quickly returned to normal.


Neuroleptic malignant syndrome and lithium carbonate.


Two weeks later the patient presented with acute oliguric renal failure, symptomatic hyperkalemia and metabolic acidosis, necessitating emergency dialytic treatment.


Two anephric patients in the course of one year erythropoietin therapy improved their anemic status without changes in Mean Arterial Blood Pressure.


Localized dyskeratotic plaque with milia associated with sorafenib.


5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.


Bradycardia and congestive heart failure associated with ocular timolol maleate.


CASE REPORT: A 29-year-old black man, HIV-infected since 1996, began highly active antiretroviral therapy (HAART) with zidovudine, lamivudine, and indinavir.


RESULTS: One day and three days after an uneventful intravitreal injection both patients experienced structured hallucinations including trees, faces, and water for approximately 15 to 30 minutes.


Gelatinous transformation of bone marrow following chemotherapy for myeloma.


Serious maternal bradycardia and asystole in laboring parturients after combined spinal-epidural labor analgesia are rare.


Low-dose methotrexate was added to their treatment regimens and led to significant improvement or clearing with a favorable side-effect profile.


Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.


A preclinical study in rats treated with TKI showed a statistically significant increase in benign and malignant renal tumours.


The patient presented with a decrease in visual acuity and pain 2 days after the procedure.


In each case, renal dysfunction and BK viral load progressed despite reduced immunosuppression, and persistent BK virus infection was documented in serial renal allograft biopsy specimens.


Cannulation of the radial artery can result in complications ranging from arterial thrombosis, arterial aneurysm, compartment syndrome, infection, nerve injury and skin necrosis to possible thumb or even hand necrosis if not recognized and treated early.


This is a clinical presentation of a 14-year-old female who had weight loss and vomiting following spinal fusion surgery.


On day 3 he was admitted and his electrocardiogram demonstrated sinus arrest with junctional escape rhythm with a rate of 42 min(-1).


The day after methotrexate administration, the patient complained of severe back pain and urinary retention.


We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.


Epoprostenol (prostacyclin) is currently approved for treatment of primary pulmonary hypertension; however, it is being evaluated in other forms of pulmonary hypertension, particularly scleroderma.


Spontaneous splenic infarction associated with sumatriptan use.