On cessation of the injections, the retrocorneal membrane grew rapidly to involve the entire posterior cornea.


Median patient age was 52 years.


A whole brain irradiation was performed for 37.5Gy with a fraction size of 2.5Gy and gefitinib was replaced with erlotinib on the 5th day after radiation therapy commenced for disease progressing.


Complex biochemical syndrome of hypocalcemia and hypoparathyroidism during cytotoxic treatment of an infant with leukemia.


The fastidious organism grew only on buffered charcoal yeast extract agar and was confirmed as L. micdadei by gene sequence analysis.


A patient who developed necrotizing pancreatitis after transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) is presented.


RESULTS: Evidence of neurological improvement and rehabilitation potential after severe myelopathy due to intrathecal injection of doxorubicin.


Diagnosis is often difficult and is typically only made in patients without another explanation for deteriorating renal function, and is often based solely on improvement after drug withdrawal.


An associated finding included a 2+ positive antinuclear antibody test with a titer of 1:320.


Patients in the intensive care unit seldom have mechanical small-bowel obstruction, and obstruction due to medication bezoars is even less common.


CONCLUSION: This observation suggests that IFN in combination with ribavirin may offer an effective therapeutic option for liver transplant patients with severe recurrent hepatitis C.


NCSE has not previously been reported in LBD.


A less frequent side effect that is becoming more recognized is neurologic toxicity.


The catheter had no blood return from either lumen for >1 month.


Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.


CONCLUSIONS: Cough has been encountered commonly after the administration of ACE inhibitors.


We discuss the limitations of conventional drug therapy and the lack of a sustained response to plasmapheresis.


There was also an improvement of the mesenteric arterial flow patterns on Doppler studies.


Especially in small prostates, care should be taken to avoid this condition.


We describe two patients who developed hypophosphatemia as a consequence of this form of therapy.


A patient with disseminated herpes zoster developed a syndrome of inappropriate antidiuretic hormone and profound hyponatremia secondary to the administration of adenine arabinoside.


Both patients had received brief courses of spironolactone before arginine treatment.


Dermatologic exam demonstrated a severe reduction of fat tissue.


Vitamin D toxicity complicating the treatment of senile, postmenopausal, and glucocorticoid-induced osteoporosis.


Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


Traditional risk factor analysis and screening were performed.


We report a 13 year-old male who developed life-threatening anaphylaxis early in the course of Increlex therapy.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


At the age of 12, a prematurely born boy with an otherwise unremarkable past medical history developed bilateral optic neuritis associated with transverse myelopathy.


The case of a young woman suffering from multiple autoimmune-dysreactive disorders (including thyreoiditis, myasthenia gravis, thymectomy, Crohn's disease, and erythema nodosum), while undergoing steroideal therapy, was complicated by a severe infectious disorder (severe upper urinary tract infection).


Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.


Three patients achieved undetectable HIV loads with enfuvirtide salvage regimens.


Extraskeletal tumoral calcifications (TC) may occur in patients with end-stage renal disease.


Periosteal infusion of bupivacaine/morphine post sternal fracture: a new analgesic technique.


We report a case culture-negative interface abscess following LASIK that was successfully treated with antibiotics and povidone iodine.


Mycobacterium fortuitum bacteremia with granulomatous hepatitis complicating home cyclic parenteral nutrition through an indwelling Broviac catheter occurred in a 41-year-old woman.


Radiotherapy enhances the toxicity of aminoglutethimide.


Single case study.


Ocular examination of both eyes revealed anterior subcapsular opacities of both lenses with the right eye being more severe than the left.


To avoid hyperuricemia and an acute attack of gout after RFA therapy for HCC, early identification of patients at risk is warranted, such as those with a large tumor, rapid tumor growth, and renal insufficiency, and preventative measures should be considered.


Therapy was continued for 8 months or longer in 6 patients, none of whom developed life-threatening infections.


If cancer and AAA coincide and curative chemotherapy is possible, a potential impact of chemotherapy on AAA expansion should be considered.


Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.


However, thereafter he suffered from serious infectious complications associated with immunosuppression and finally died 11 months after APOLT.


It carries a well-known risk of neutropenia and agranulocytosis, which necessitates the immediate discontinuation of clozapine.


CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.


However, two children responded to the series of injections of hydrocortisone but not to single doses of methylprednisolone.


Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.


Excessive level of parathyroid hormone may induce the reduction of recombinant human erythropoietin effect on renal anemia.


Torsade de pointes represents a potential complication of chronic amiodarone therapy.


started having backache, fever and became operatively.


Black cohosh is one of the most popular herbal therapies for premenstrual discomfort, hot flushes and other climacteric and menopausal symptoms.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


Healthcare providers and members of the public should be aware of the potential adverse effects of these remedies.


Physicians should suspect pulmonary toxicity in patients with respiratory distress after gemcitabine chemotherapy, mainly in elderly patients.


Risperidone-induced psychosis and depression in a child with a mitochondrial disorder.


Toxic streptococcal syndrome is characterized by fever, shock, multiorgan system failure and a desquamating scarlatiniform rash.


Furthermore, inadequate control of hypertension may have been another cause of hemorrhage.


The patient developed infectious complications and died on hospital day 32.


Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.


Severe rhabdomyolysis developed within 5 hours after the injection.


Therefore we recommend the less invasive approach first--urokinase therapy--to be followed by surgical intervention if thrombolysis is unsuccessful.


An uncommon manifestation of phototoxicity, photo-onycholysis results in the separation of the distal nail from the nail bed.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


Because of serious side effects of an increase in the QT interval causing torsades de pointes, dofetilide must be initiated with close monitoring of the QT interval in an inpatient setting.


A 35-year-old woman was admitted to our hospital with the following complaints, headache, sweating, anxiety, dizziness, nausea, vomiting and severe hypertension.


Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion.


Antiphospholipid syndrome is an autoimmune disease that is characterised by tendency to thrombosis, obstetrical and hematological complications.


Safety of nab-paclitaxel plus sunitinib: analysis of three cases.


Reduction of methylprednisolone dosage rather than insulin therapy resulted in better control of glycemia.


Symptoms resolved when systemic corticosteroids were administered.


Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.


OBJECTIVE: To describe a series of patients with clinically significant lead poisoning.


Coronary thrombolysis is contraindicated in patients with transient cerebral ischemia and stroke, arterial hypertension, cerebral trauma, cerebral aneurysms, and arteriovenous malformations, because of the risk of cerebral hemorrhage.


He had received treatment with 400 mg of imatinib per day for 77 days, followed by dasatinib for 133 days.


Antimonial derivatives induced a rapid remission.


Treatment with sodium bicarbonate readily corrected a potentially life-threatening cardiac arrhythmia and is therefore suggested to be imperative in the treatment of these cases.


Total scaphoidectomy and appropriate antibiotic therapy eradicated the infection.


The patient was hospitalized and treated with a bolus as well as continuous infusion of intravenous magnesium sulfate.


Despite significant improvement, extended plastic surgery was necessary for facial reconstruction.


Two years later, his treatment was switched to olanzapine.


Hyperosmolar hyperglycemic nonketotic coma.


PURPOSE: The intravitreal application of triamcinolone acetonide as treatment of long-standing, therapy-resistant cystoid macular edema after penetrating keratoplasty is reported.


We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).


The clinical course as well as the biochemical pattern and the investigation of liver biopsy specimens enabled us to establish the diagnoses of drug-induced canalicular and hepatocanalicular cholestasis.


Importantly, this was the first time that information became available about the effects of tamoxifen in healthy women, that is, women who did not already have breast cancer.


A 42-year-old male underwent a total hip arthroplasty under subarachnoid anaesthesia with intrathecal bupivacaine and diamorphine.


Surgery to remove the remaining tumor was performed 19 days later.


Gastric mucosa hyperplasia is a rare cause of upper gastrointestinal obstruction in the neonatal period.


A 69-year-old man with ulcerative colitis (UC) developed sensorimotor polyneuropathy.


Subacromial impingement syndrome as a consequence of botulinum therapy to the upper trapezii: a case report.


The patient's pain was well controlled with 10 mg continuous release morphine p.o. three times daily, and 10 mg immediate release morphine p.o. for breakthrough pain as required.


He had been taking trimethoprim-sulfamethoxazole for approximately eight days when he revisited his family physician, complaining of headaches, dizziness, difficulty with speech, weakness, and itching on the trunk of his body and legs, where a maculopapular rash was noted.


We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.


The possibility can be raised that M-CSF accelerated the underlying renal disease in this case through enhancing macrophage accumulation into the glomerulus, leading to the development of nephrotic syndrome.


Thus, olanzapine dose reduction may permit treatment continuation where this is clinically indicated.


Intravenous verapamil therapy in babies may cause apnea, hypotension, and bradycardia; continued episodes of atrial flutter in a child may cause sudden death; quinidine may be related to the death; children with "familial seizure disorders" may in fact have the long QT interval syndrome.


The neurotoxicity was associated with oculomotor disturbances expressed primarily as weakness of convergence and divergence.


This case describes the complications and successful treatment of high-dose intrathecal morphine overdose.


The pupils were pinpoint.


Hemostatic physiology involves a complex interlinking of blood and endothelial factors.


We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.


Management of Graves' ophthalmopathy includes high-dose glucocorticoids.


Bronchoscopic, cytologic, histopathologic, and virologic studies confirmed that necrotizing and exudative tracheobronchitis was due to herpes simplex virus.


The blindness may have been a consequence of an immune reactivation inflammatory syndrome caused by this treatment.


Hepatic hyperechogenicity on ultrasonography and slight elevation of serum transaminases might erroneously lead to a diagnosis of hepatic steatosis without liver histology.


SETTING: Gimbel Eye Centre, Calgary, Alberta, Canada.


After identification of the index patient, additional inquiry revealed that the patient's mother was hospitalized previously for overwhelming sepsis associated with metamizole use.


Cultures of the anterior chamber were positive for Candida glabrata.


Pharmacokinetically induced benzodiazepine withdrawal.


The clinical manifestations of an anaphylactoid reaction are identical to true anaphylaxis; however, a previous exposure to the offending agent is not needed to manifest these symptoms.


Early ICP was elevated, >50 mm Hg, and continuous EEG monitoring showed isoelectric readings.


It is suggested that high dosage corticosteroids may damage the posterior blood-ocular barrier.


Mexiletine hydrochloride was useful in preventing recurrences of torsades de pointes.


It may or may not be accompanied by other features of toxicity.


DATA EXTRACTION: Data from pertinent published sources were reviewed and abstracted.


An acute ischaemic event associated with the use of venlafaxine: a case report and proposed pathophysiological mechanisms.


CONCLUSIONS: In these 3 cases, the unique positive ocular finding was corneal endothelial deposits, which may be related to the use of rifabutin.


All-trans-retinoic acid (ATRA) is considered the recommended induction treatment for acute promyelocytic leukemia (APL).


While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect.


The patient responded to aluminum chloride applied topically.


In addition to the therapeutic benefits, prospective monitoring of free SDC in two of the patients also may have resulted in cost savings secondary to reduced hospital stay or less use of Fab.


Antiretroviral-induced hepatic steatosis and lactic acidosis: case report and review of the literature.


Although few reports of side effects have been published complications such as priapism and fibrosis of the spongy tissue are of concern.


Progressive outer retinal necrosis presenting with isolated optic neuropathy.


A 14-year-old girl with newly diagnosed SLE developed a pruritic bullous eruption while on prednisone.


To our knowledge, neither the association of SINS and ankylosing spondylitis nor vertical diplopia as its presenting complaint has been described.


These reports suggest the possibility that the risk of developing hyperglycemia and diabetic coma with this combination may be greater than when taking diuretics alone.


At 8 years 8 months of age, desensitization was attempted because of refractoriness of seizures to drugs other than phenytoin.


Rapid diagnosis may avert unnecessary changes in therapy to treat conditions which clinically mimic NEH.


We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.


It was possible to reproduce the disease by the intradermal injection of killed Group A streptococcal organisms.


We administered SKT for a patient with thoracic outlet syndrome (TOS) complaining of several resting symptoms.


Administration of excessive insulin induced hypoglycemia within 4 to 8 hours, followed by rebound hyperglycemia.


Rapid formation of Aspergillus mycetoma in a patient receiving corticosteroid treatment.


Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.


Recent reports have shown that Decadron (dexamethasone; Merck Sharp & Dohme, West Point, Pa) has a significant antiemetic effect on cisplatin-induced vomiting.


Dystonia is a common manifestation in Wilson's disease (WD).


Iatrogenic vasculitis should be suspected when a patient with idiopathic vasculitis with one type of ANCA develops the other type of ANCA.


Nodular scleritis following alendronate therapy.


After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.


However, long-term PUVA therapy may cause several adverse effects including skin cancer, especially squamous cell carcinoma (SCC).


Bilateral Acanthamoeba keratitis in Synergeyes contact lens wear: clinical and confocal microscopy findings.


Atrial fibrillation after vardenafil therapy.


Pentavalent antimonial drugs used for the treatment of leishmaniasis have been associated with sudden deaths, probably due to the development of ventricular tachyarrhythmias.


Treatment with r-HuEPO does improve the quality of life and ability to work of uremic patients and does not adversely affect their transplant potential.


BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.


A mechanism for the efficacy of this treatment is discussed.


BACKGROUND: Bupropion, a novel antidepressant, has been reported to produce fewer adverse effects than the tricyclic antidepressants.


The first patient showed a good response to olanzapine, but the RLS symptoms associated with olanzapine resulted in poor long-term compliance, eventually leading to frequent relapse of psychotic symptoms.


The present report examines the case of a patient with longstanding Crohn's disease who had never been treated with corticosteroids and who developed osteonecrosis of the talus.


Optometrists should be familiar with this condition, its signs, symptoms and correct treatment protocol.


Specifically, after initiation of 500 mg MMF twice a day given in conjunction with the long-standing use of prednisone, which had been tapered to a dose of 10 mg daily, the patient's red blood cell count dropped by 17% over 7 weeks.


However, 19 days after starting amiodarone, serum testing indicated a hypothyroid status that was not recognized clinically.


There is growing evidence that various organic solvents give rise to a parkinsonism syndrome with pyramidal features in susceptible individuals.


Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).


We present a patient with multiple intraoral ulcerations of the right buccal and alveolar mucosa that had previously been treated with nerve ablation therapy for trigeminal neuralgia.


To ensure safety and effectiveness, and to meet the requirements of accreditation agencies, hospitals should develop prescribing guidelines for IV opioid range orders and clear protocols for their implementation.


Flurbiprofen-associated acute tubulointerstitial nephritis.


The patient received only the ophthalmic sulfonamide, and it was used for one day, but he developed Stevens-Johnson syndrome.


While the 2 patients without re-exposure to etanercept did not have further CD flares, the third patient flared 6 months after re-institution of etanercept in combination with azathioprine.


In this brief report, we present case of successful cisplatin administration following two unsuccessful carboplatin desensitization attempts, and without the need for pre-treatment steroids.


Initial measurements showed the patient was able to walk for one minute and 34 seconds on a treadmill (2 mph, 10% grade) before stopping because of claudication.


After 4 months, the pain had almost entirely disappeared.


A diffuse intrahepatic metastasis of a carcinoid was treated with a loco-regional intraarterial chemotherapy via a catheter system implanted in the gastroduodenal artery.


This report describes a male college student who experienced akinesia lasting almost 3 weeks following withdrawal from relatively brief, low-dose neuroleptic treatment.


Acute abdomen due to endometriosis in a premenopausal woman taking tamoxifen.


OBJECTIVE: The objective of this study was to assess the efficacy of beta-blockade on clinically significant left ventricular outflow tract obstruction in premature infants treated with dexamethasone because of bronchopulmonary dysplasia.


After mirtazapine therapy was discontinued, serum sodium concentrations normalized.


Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.


Histopathology showed an increase in melanocyte numbers and melanogenesis.


The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.


We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.


Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.


Testicular teratoma with a unique mode of spread and spontaneous maturation.


A case report.


BACKGROUND: A 56-year-old man with normal cardiac function received treatment with interferon alpha-2b for malignant melanoma.


Patch testing to individual components revealed positive reactions to all ingredients except aloe.


It is concluded that selective 5-HT4 agonists could be potentially useful to improve bladder emptying in micturition disorders associated with detrusor hypocontractility.


Definitive diagnosis was obtained after a mean period of 4.5 weeks (range, 12 days-8 weeks) from onset.


Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported.


A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy.


Mycobacterium bovis dissemination (BCG strain) among immunodeficient Brazilian infants.


We describe a woman with relapsed cutaneous follicular centre B-cell lymphoma and secondary lymph-node involvement treated with rituximab alone, which induced a complete remission.


Clonidine-induced bradycardia in patients with spinal cord injury.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


Environmental agents have long been thought to be linked to the development of malignancies.


However, recently we were confronted with two cases within 1 month.


CLINICAL FEATURES: A 34-yr-old man with long-standing insulin dependent diabetes mellitus underwent a total proctocolectomy for inflammatory bowel disease.


In more than half of the cases there was evidence of prolonged elimination t1/2 or rebound of a serum concentration during the elimination phase corresponding to either an additional compartment or enterohepatic circulation of 6MP.


Since this reaction was not present on the original aspiration cytology slides, the chemotherapy treatment must have induced this reaction.


There have been conflicting reports as to whether clozapine, an atypical antipsychotic, will suppress symptoms of tardive dyskinesia.


Drug induced acute parotitis is a very uncommon complication reported with a few drugs only.


Severe tardive dystonia: treatment with continuous intrathecal baclofen administration.


We conclude that, though rare, E. avium can be pathogenic in humans and that E. avium bacteremia is associated with gastrointestinal abnormalities.


Two hours after a documented overdosage of more than 100 tablets oxcarbazepine, the serum level of the parent compound was 10-fold higher than the therapeutic dosage (31.6 mg l(-1)).


In addition to PIA1 platelet antibodies, this patient had an associated anamnestic recall of multispecific red cell and lymphocytotoxic antibodies.


The severity of the haemorrhagic diathesis prompted us to describe the case in order to draw the attention of medical personnel to the dangerous potentiation effects of different drugs administered with vitamin K antagonists.


Approximately 1 year after symptom onset he developed mild seropositive oculobulbar myasthenia gravis, which spontaneously remitted after 5 months.


Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.


This potentially fatal complication is difficult to treat and should be widely known.


Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.


The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.


She had, in July 1977, severe claudication of the lower extremities.


Suppression of endogenous cortisol production and replacement with more physiologic concentrations of glucocorticoid were associated with clinical improvement and appeared to contribute to her recovery.


She developed a wide complex dysrhythmia which responded to sodium bicarbonate therapy.


A senile patient showed a dramatic recovery from medication-resistant depression after non-convulsive electroshock therapy (nc-EST), with a lasting change in response to trazodone, which mainly acts as a serotonin re-uptake inhibitor.


Verapamil, a class IV anti-arrhythmic drug that blocks voltage-dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage-dependent calcium channels at the neuromuscular junction.


Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.


MEASUREMENTS AND MAIN RESULTS: Extensive noncardiogenic pulmonary edema.


We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.


Hepatic reactions to cyclofenil.


Bilateral subthalamic nucleus stimulation results in reversal of alopecia in Parkinson's disease.


These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.


We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.


We describe such a case who responded to chemotherapy and not to low doses of corticosteroids.


This "fibroelastic form" would represent the acute or subacute phase of constriction.


Disseminated toxoplasmosis with pulmonary involvement after heart transplantation.


The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.


Color Doppler imaging of the thyroid gland in a fetus with congenital goiter: a case report.


The infiltrates did not affect the refractive outcome of the surgery.


We report the outcomes of two pregnancies with first trimester disulfiram exposure.


Seven months after undergoing a syngeneic PBSC transplant for AML, our patient presented with fever without localizing signs.


In conclusion that immunocompromised patients with impaired cellular and humoral immunity are at risk for the development of opportunistic infections and hematologic abnormalities.


We report three patients with transformed migraine, previously refractory to a wide variety of traditional preventive pharmacologic and nonpharmacologic interventions.


Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma.


We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.


However, we cannot exclude a primitive effect of erythropoietin on the endothelium or on the platelets.


No flares were observed either in clinical symptoms or in laboratory examinations during pregnancy or after delivery.


BACKGROUND: 5-fluorouracil (5-FU) targets rapidly dividing cancer cell populations.


Tetracycline and benign intracranial hypertension: report of five cases.


He recovered completely after lamivudine therapy was started, but this severe adverse event could have been prevented if screening for HBV and pre-emptive therapy with lamivudine would have been started prior to infliximab.


Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.


We describe a heart transplant patient who presented with a large right-sided chest wall mass as a manifestation of disseminated histoplasmosis.


Five of 157 (3.2%) patients with small cell carcinoma were clinically diagnosed as having the ectopic ACTH syndrome.


Six days after starting acyclovir she exhibited signs of lithium toxicity.


Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.


We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.


The signs and symptoms were similar to those seen with systemic use of the drug for other ailments.


Pleural and broncheoalveolar fluid analyses (BAL) showed eosinophils.


We identified NAT2*6/*7 in one patient, and NAT2*6/*5 in the other, suggesting that both were slow acetylator phenotypes.


OBSERVATIONS: In both patients, at the time of the visual disturbances, macular edema was clearly observed by OCT.


The association between choroidal neovascularization (CNV) and retinal vein occlusive disease is uncommon.


This is not a controlled study but an anecdotal experience that resulted in improved outcomes in a patient with multiple allergies, including iron dextran.


Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.


We report a 34-year-old man with a history of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), treated with different chemotherapy regimens, including anthracyclines and Rituximab.


The areas under the curve for theophylline alone and theophylline with zafirlukast were 29.3 and 197 (mg x h)/L, respectively.


All patients except two had new recurrences within the observation time.


Corticosteroids were found to worsen and prolong the course of disease.


On hospital day 47 (day 45 of nesiritide therapy), the patient received an 18-fold overdose of nesiritide, with no hemodynamic, cardiac, or renal sequelae.


Resting motor threshold (RMT), active motor threshold (AMT), MEP size, intracortical inhibition (ICI) and intracortical facilitation (ICF) were tested during and after suspension of hormonal therapy.


METHODOLOGY: A case series of nine patients with lead poisoning who required inpatient management, identified through a Clinical Toxicology Service.


INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.


Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.


Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.


Thirty-four thousand one hundred eighty-one patients with computerized ECGs were screened for QTc prolongation.


METHODS: A 54-year-old healthy male underwent uneventful bilateral LASIK for the correction of myopia and astigmatism (-5.75 -3.00 x 20 degrees right eye, -5.50 -3.00 x 170 degrees left eye).


We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.


Adult patients with transfusional hemosiderosis were given ascorbic acid and treated with the iron chelator, desferrioxamine B.


A recent consensus suggested that endoscopic injection of tissue glue for gastric variceal obliteration (GVO) should be the first choice for treatment of acute gastric variceal bleeding.


Within the past 10 years, 47 cases of BC infection have been published.


Peripheral neuropathy associated with capecitabine.


Vincristine induced cranial polyneuropathy.


The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.


OBJECTIVE: We report two cases of lost seizure control associated with the generic substitution of carbamazepine, review pertinent literature, and discuss the impact of this substitution on patient care.


We describe three patients who had been exposed to various solvents for more than 20 years (25, 34, and 46 years).


Diclofenac and increasing doses of opioids did not give adequate pain relief and led to opioid toxicity.


We report here a 34-year-old woman with complicated severe opportunistic pulmonary infection, who was treated with the newly developed antibiotics quinupristin/dalfopristin (QPR/DPR) and voriconazole.


We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.


After the moxifloxacin was stopped, the corrected QT interval normalized and a permanent cardiac pacemaker was implanted.


An effective schema for the treatment of tardive dyskinesia includes avoiding antiparkinsonian medication and prescribing deanol, an acetylcholine precursor, while continuing or increasing phenothiazine dosages.


Bacteriological culture of the removed graft identified Escherichia coli and Peptostreptococcus.


He underwent liver biopsy and biochemical screening to evaluate whether he would benefit from interferon (IFN) treatment.


A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.


The challenge case showed eosinophilia with 1.2 10(9)/l (z = 1.79, p = 0.04) being followed by normalization despite clozapine continuation, whereas the maximum value reached 2.1 10(9)/l in the single episode case, with consecutive normalization and uninterrupted treatment.


Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.


However, peripheral and cerebral embolism occurred.


To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.


Further research and better communication among health care professionals are needed to determine if prophylaxis can reduce adverse ocular events.


Chronic fentanyl application induces adrenocortical insufficiency.


Clinical and histological information on three additional patients seen at two institutions (Rochester Methodist Hospital, Rochester, MN, and Fairview-University Medical Center, Minneapolis, MN) by the authors were also compiled.


EBV-associated post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication following solid organ transplantation and hematopoietic stem cell transplantation (HSCT) using bone marrow or peripheral blood as stem cell sources, but rarely reported in umbilical cord blood transplantation (UCBT).


The tyrosine kinase activity and its effects represent a potential pharmacologic target of tyrosine kinase inhibitors, such as imatinib.


METHODS: A retrospective case series and chart review of all patients treated in our tertiary care private practice for late-onset interface inflammation associated with elevated intraocular pressure.


As a result of this and other evidence, the investigation of the adoptive parents was terminated.


A 57-year-old male, known admitted for below knee amputation, with infection and gangrene of the left foot.


An 18-year-old male patient was under treatment with infliximab at a dose of 5 mg/kg at Weeks 0, 2 and 6 for refractory Crohn's disease.


A case report.


Dental management for head and neck cancer patients undergoing radiation therapy: comprehensive patient based planning--a case report.


This is our first well-documented observation of persistent cutaneous anesthesia caused by a spider bite.


We report a case of a 65-year-old man suffering from a dilatative cardiomyopathy and concomitant MRSA infection who received a biventricular assist device.


Antipsychotic medications have been associated with significant cardiovascular adverse effects and instances of sudden cardiac death.


A 54-year-old female was admitted to our hospital for gingival bleeding and was diagnosed as acute promyelocytic leukemia (APL).


MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.


Differential diagnosis and theories regarding the development of these neuroleptic-induced disorders are reviewed.


Atypical haemolytic uraemic syndrome as a complication of induction chemotherapy for acute lymphoblastic leukaemia.


The patient improved with vancomycin and high-dose ampicillin therapy.


Following recovery, the parathyroid glands were shown to respond normally to a phosphate load.


Current dosing guidelines for intravenous azithromycin can result in much higher serum concentrations than is seen with oral administration.


In rare cases mitomycin C (MMC) may induce cancer-associated hemolytic uremic syndrome, which is characterized by hemolytic anemia, thrombocytopenia and progressive renal failure.


Toxicity is usually limited to anticholinergic symptoms.


Acute and transient ST segment elevation during bacterial shock in seven patients without apparent heart disease.


An unusual complication of immunosuppression in myasthenia gravis: progressive multifocal leukoencephalopathy.


Both patients experienced problems due to side effects from the anti-MAC regimen and from an immune-reconstitution syndrome related to HAART.


One year subsequently, he developed a nasal septal perforation.


After 39 hours on argatroban, the infusion was stopped when minor bleeding was observed with a concurrent activated partial thromboplastin time (aPTT) of 100 seconds.


The valid risk factor for developing retinopathy is hypertension.


The patient's disease involved the palate, nose and sinuses, and had been unresponsive to conventional therapy.


Anxiety dreams and night terrors have been reported as complications of single-dose bedtime administration of both tricyclic antidepressants and neuroleptics.


Exclusion of other causes strengthened this conclusion.


Like other atypical neuroleptics olanzapine is considered to show a reduced prevalence of extrapyramidal side effects when compared to classical neuroleptic drugs.


Herbal products have been associated with a wide spectrum of hepatic toxicities.


Intravenous hydration with normal saline was initiated as the patient had normal kidney function, and urinary output was monitored.


We report here a case of TEN after administration of ciprofloxacin.


With a follow-up duration of 3-4 months, we observed no toxicities outside of well-known side effects including some degree of myelosuppression and fluid retention.


Fluorescein angiography demonstrated multiple leakage points; indocyanine green angiography disclosed large hyperfluorescent patches in the choroid and OCT demonstrated retinal detachment with dense subretinal deposits.


Intra-articular glucocorticoid injection: an unusual cause of transient hypophosphataemia.


CONCLUSIONS: The rapid resolution of this patient's symptoms after discontinuing propafenone therapy and the absence of recurrence lend credence to the probability of this effect.


We report a case of a male infertility patient with asthenozoospermia during long-term treatment with anti-epileptic drugs.


Since propylthiouracil is an equally effective antithyroid agent and has not been associated with ACC, it is the preferred thioamide for hyperthyroidism during pregnancy.


Approximately 2 weeks after surgery, the patient was referred to Stanford University, with 20/400 visual acuity in the left eye and a stromal infiltrate posterior to the flap.


Vancomycin was changed to teicoplanin and the agranulocytosis resolved 4 days later.


We report a case of Graves' hyperthyroidism induced by long-term interferon (IFN) therapy.


Treatment of cerebrospinal fluid and syringosubarachnoid shunt infection with systemic and intrathecal antibiotics.


We present a series of cases of phenytoin toxicity where the diagnosis was initially missed.


Two case reports and data from literature on the subject are used by the authors to describe characteristics of pathogenetic importance of neuroleptic induced stupor (NIS).


DISCUSSION: Drug hypersensitivity reactions are the most common cause of AIN.


After a six-week course of low-dose cyclosporine A, she developed a severe but reversible loss of glomerular filtration rate and effective renal plasma flow despite of low cyclosporine A plasma levels.


A second opinion concurred.


She died of fungal pneumonia 30 days later.


Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.


A 74-year-old hypercholestrerolaemic woman taking cerivastatin (0.15 mg/day) for 22 days complained of general muscle weakness and muscle pain.


A case report.


DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.


We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine.


The response to intravenous corticosteroids was dramatic, but lesions recurred after their withdrawal.


Such agents include anthracyclines, taxanes and capecitabine.


However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.


Pathogenic mechanisms for the development of pseudomembranous colitis and the epidemiology of this condition in patients with AIDS are discussed.


Early symptoms included fever, malaise, and vague gastrointestinal symptoms.


Postoperative analgesia was withheld secondary to intermittent oxygen desaturation.


Acute myeloid leukaemia was diagnosed 4 and 5 years after G-CSF mobilisation in two donors who underwent peripheral blood stem cell donation for sibling allogeneic haematopoietic stem cell transplantation.


CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.


Ten months after discontinuing tamoxifen, she underwent exploratory laparotomy for a right adnexal mass suspected as ovarian malignancy.


A 10-year-old boy with osteosarcoma and normal renal function manifested laboratory evidence of impending renal toxicity and extreme elevation of aspartate aminotrasferase and alanine aminotransferase within 2 hours after the completion of a 4-hour infusion of high-dose methotrexate (MTX) (12 g/m2), and went on to develop acute renal failure with life-threatening hyperkalemia 29 hours later.


Piloerection induced by replacing fluvoxamine with milnacipran.


Though hypotension, dry mouth, and constipation are well-documented possible adverse effects, the possibility of clonidine-induced bradycardia is less well recognized and is rare.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


All patients received infliximab.


A patient with psoriasis is described who had an abnormal response to the glucose tolerance test without other evidence of diabetes and then developed postprandial hyperglycemia and glycosuria during a period of topical administration of a corticosteroid cream, halcinonide cream 0.1%, under occlusion.


The patient's lymphocytes showed no proliferative response to zomepirac.


MATERIALS AND METHODS: The clinical stage according to the Japanese Classification of Esophageal Cancer 7th ed. was stage III in 2 cases and stage IVa in 1.


In the Perugia Consensus Conference it was decided that the recommended antiemetic regimen in the prevention of acute emesis induced by a single high, low and repeated doses of cisplatin is a serotonin receptor antagonist plus dexamethasone.


In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.


Discontinuation of linezolid and a short course of prednisone led to rapid improvement of renal function.


Mutation analyses were performed by the John F.


STUDY DESIGN: Case report.


Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.


WE is usually associated with alcoholism and malnutrition.


Henna (Lawsonia inermis Linn.) induced haemolytic anaemia in siblings.


The profound hyperkalemia that occurred in these two patients is thought to be the result of an inability to metabolize the administered arginine and excrete the excess extracellular potassium.


An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


The withdrawal of MMI and early treatment with 5 microg/kg per day recombinant human granulocyte colony-stimulating factor (G-CSF) for 9 days, allowed a favorable recovery of peripheral blood cell count.


These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.


Clinical and morphological features of gold neuropathy.


Rituximab, a humanized monoclonal antibody approved for malignant lymphoma, is being increasingly, effectively, and safely used for immune thrombocytopenic purpura (ITP) and other humoral autoimmune disorders.


Mercury is considered a weak sensitiser and contact with mercury salts such as chloride or ammonium chloride may cause hypersensitivity leading to contact dermatitis or Coomb's Type IV hypersensitivity reactions.


In this case report we describe the occurrence of oral lichen planus-like lesions as the first manifestation of chronic GVHD (c-GVHD) and the subsequent management of this disease with topical tacrolimus.


Iron was absent.


Pseudomonas spp. are of increasing importance in human immunodeficiency virus-infected children causing significant morbidity and increased hospitalization.


Nocardial brain abscess is a rare but severe complication in patients with malignancy.


The liver abscess had resolved almost completely on ultrasonography after 2 weeks of therapy.


On this regimen, four of the five patients studied were able to excrete significant amounts of iron (greater than 35 mg/da) when receiving a daily desferrioxamine dose of 1.5 to 2.2 g.


Liver function continued to deteriorate, and the patient underwent liver transplantation 17 days after admission.


Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.


DISCUSSION: This case shows that a clinically significant interaction between bosentan and warfarin may exist.


A 62-year-old woman treated with pranlukast for 2 months developed interstitial pneumonitis with a high fever.


METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.


The association of malignant mesothelioma with lymphoma is rare, and the possibility of asbestos exposure as a common etiology is discussed.


Neuroleptic malignant syndrome.


In 3 of the 5 patients (60%) at 12 months after treatment, plasma cell dyscrasias could not be detected.


Atrioventricular block complicating amiodarone-induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block.


3. Multiple myeloma and Hodgkin's disease, both of which commonly have good responses to chemotherapy, predominate as the underlying diseases.


In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.


(<or=31 repeats is normal, 32-35 is borderline, >or=36 is pathogenic).


Report of four cases.


While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.


Her laboratory findings were as follows: platelet count 1000/ mm3 hematocrit 39%, WBC 7300/mm3 and RBC 466 x 10(4)/mm3.


From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).


Both infants initially responded well to medical therapy for narcotic withdrawal, but at 7-14 days of age, withdrawal symptoms intensified, requiring an increase in the dosages of Paregoric (UDL Laboratories, Rockford, IL) and opium tincture in both infants and the addition of phenobarbital therapy in one infant.


Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.


The mechanism of this unusual early and extreme rise of fibrinogen levels is unclear but it probably played a role in the pathogenesis of the cerebrovascular accident.


Standard pretransfusion testing was uncomplicated; however, after infusion, the serum was no longer compatible with the transfused units and a strong (4+) panreactive IgG antibody was detected.


A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.


Lithium for irritability in post-traumatic stress disorder.


Hypernatraemia induced by sodium polystyrene sulphonate (Kayexalate) in two extremely low birth weight newborns.


Recurrent hyponatremia associated with citalopram and mirtazapine.


Drug-induced antisynthetase syndrome.


Serial hemograms were characterized by persistent thrombocytosis (platelet count, 577,000 to 1,200,000/microl) with abnormal platelet morphology.


A complication associated with central line removal in the pediatric population: retained fixed catheter fragments.


Treatment of lithium tremor with metoprolol.


The patients were treated with quetiapine as relapse prevention and we followed them up in our outpatient clinic.


Hypercalcemia in an AIDS patient treated with growth hormone.


Generalized seizures were observed, and the patient lapsed into status epilepticus followed by cardiac arrest and subsequently expired.


Magnesium tocolysis as the cause of urinary calculus during pregnancy.


FINDINGS: Histological examination of two cases revealed meningothelial meningioma.


The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.


Growth failure is a recognised feature of Gitelman syndrome, although it is not as frequent as in Bartter syndrome.


RESULTS: Confocal and specular microscopy confirmed permanent endothelial cell loss with morphologic alteration after intracorneal penetration of ushaar latex.


The clinical presentation was highly suggestive of malignancy and the patient underwent diagnostic mediastinoscopy with biopsy.


However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.


When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug.


The higher the number of Japanese who go abroad becomes (the total number in 1994 was 13,578,934: Records of Statistical Division of the Ministry of Justice), the greater is the risk of their contracting malaria.


All-trans retinoic acid (ATRA) has been shown to improve the outcome in patients with acute promyelocytic leukemia compared with chemotherapy alone, but it is associated with adverse effects.


These cases prompted an investigation of metamizole use in an urban pediatric clinic, which revealed that 35% of Spanish-speaking Latino families had used metamizole; 25% of these families had purchased the medication in the United States.


Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.


A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.


He later recovered normal visual acuity.


CONCLUSION: This rare case of PTU-induced ANCA-associated vasculitis manifested with ototoxicity in combination with systemic involvement.


We propose a mechanism of vancomycin-induced mast cell degranulation and subsequent release of eosinophil chemotactic factor as a cause of CSFE.


All patients showed marked aphasia and other cognitive deficits.


Therefore doses were adapted on the 3rd day of the course.


IMPLICATIONS:We discuss the successful management of gangrene of the upper and lower limbs after ergot-induced abortion by unlicensed medical charlatans in a developing country.


In one infant the hemorrhage was accompanied by communicating hydrocephalus.


Thrombosis of the left main coronary artery complicating percutaneous transluminal coronary angioplasty has, to our knowledge, not previously been reported.


We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.


However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.


Two anaphylactic deaths after chemonucleolysis.


The implants occurred at the site of insertion of laparoscopy trocars.


Eleven surviving patients were also studied by analysis of serum aminoterminal propeptide of type III procollagen (PIIINP), which is an indicator of fibrogenesis, which is especially suitable for follow-up of fibrotic liver disease.


Intravenous administration of levodopa ameliorated a refractory akathisia case induced by interferon-alpha.


The management of non-muscle invasive bladder cancer has become more complex with regard to initial investigation, treatment and follow-up.


Thirty-four children with acute lymphoblastic leukaemia (ALL) in relapse or resistant to initial induction received combination chemotherapy with prednisolone, vincristine, l-asparaginase, and daunorubicin.


We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.


Pyoderma gangrenosum related to a new granulocyte colony-stimulating factor.


Diffuse lamellar keratitis after corneal crosslinking in a patient with post-laser in situ keratomileusis corneal ectasia.


There are eight reported cases in the literature.


It occasionally accompanies the heparin-associated thrombocytopenia and thrombosis syndrome.


Patients may also experience delirium as part of their underlying medical conditions.


The side-effects and unusual pharmacokinetics of phenytoin are discussed, as well as the array of potential drug interactions.


These were caused by simultaneous administration of vitamin K antagonists and anti-inflammatory drugs.


We believe this practice is inappropriate because of the inability of ACE inhibitors to lower blood pressure in patients with low renin levels.


Her physical appearance, elevated and relatively nonsuppressible plasma cortisol levels, and radiologic study supported a tentative diagnosis of Cushing's syndrome in a critically ill patient.


The reaction, documented by rechallenge during hospitalization, was characterized by marked hypotension, fever, rigors, conjunctivitis, meningitis, nausea, arthralgias, and leukopenia.


The effects of lorcainide, a new antiarrhythmic drug, on serum electrolytes and osmolality are described in a series of 33 patients with organic heart disease and complex ventricular arrhythmias treated with lorcainide.


We plan to do a Holter study during the period of bradycardia in subsequent patients and this may throw more light on the issue.


Successful treatment of mucormycosis after kidney transplantation.


Clinicians should be alert to the possibility of these adverse effects in children treated with these drugs.


Successful treatment of Staphylococcus aureus bacterial endocarditis in a renal transplant recipient.


Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.


Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.


Although the disorder is not thought to have a genetic background, there are some familial case reports in the literature.


Other agents known for such association are serotonin (5-hydroxytryptamine) and beta-adrenergic blockers.


Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene).


Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.


We report a case of stutter priapism successfully treated with an oral antiandrogen.


Both were managed conservatively.


I report the case of a patient who developed tuberculosis after a Billroth II subtotal gastrectomy, malabsorbed his antibiotics, and subsequently manifested infection with a drug-resistant strain of M tuberculosis.


Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.


Acute renal failure most likely was secondary to the nephrotoxic effect of captopril on chronically hypoperfused kidneys.


ADH hypersecretion in relation to plasma osmolality was reversed by mizoribin withdrawal, suggesting that bredinin might adversely induce SIADH.


Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)


We present four cases that illustrate that HL may be seen in non-HIV and nonimmunocompromised patients.


The patient was treated with intraparotid injections of botulinum toxin.


No severe local side effects were observed.


Thromboembolic phenomenon is rare but serious consequence of ovarian hyperstimulation syndrome (OHSS) and in vitro fertilization (IVF) treatment.


Endarteritis by inflammation of the leptomeninges is known to be its cause.


Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature.


The clinical symptoms of both may be similar, and their clinical courses may be monophasic or multiphasic, mild but also very aggressive.


We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.


CLINICAL FEATURES: A 74-yr-old, 51-kg woman with a history of hypertension controlled with 5 mg.day-1 enalapril and 50 mg.day-1 atenolol was admitted for evaluation of low back pain, loss of appetite, and weight loss.


The "holiday heart" syndrome.


After treatment with cimetidine, there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values.


Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA).


The known side effects of sibutramine, ie, hypertension and tachycardia, depend on its adrenergic and serotoninergic effects.


Disseminated Ureaplasma urealyticum infection in a hypo-gammaglobulinaemic renal transplant patient.


Renal injury due to anastrozole has not been published in the English literature.


A prerenal component could have contributed to renal failure because of a transient hypotension, due to an increasing ascitis, occurring just before anuria.


Additionally, irregularities in the cone photoreceptor density and mosaic were seen in areas with normal HVF 10-2 and SD-OCT findings.


A 5-year-old girl was diagnosed preB cell Acute Lymphoblastic Leukemia (ALL).


We describe a case of hyperchloraemic metabolic acidosis with hypoaldosteronism in a 4-year-old boy with nephrotic syndrome who was receiving ACE inhibitors.


The main clinical features of this 58-year-old female patient were laboratory evidence of leucopenia and cholestasis, and biopsy features of fatty liver parenchyma degeneration with granulocytic portal infiltration and bile stasis, demonstrated 20 days after the initiation of antithyroid therapy with 20 mg methimazole daily.


An aqueous humor tap was performed and sent for polymerase chain reaction analyses of Herpes simplex, Herpes zoster, and Mycobacterium tuberculosis (MT).


CONCLUSIONS: Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs.


As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.


The reason for occurrence of cutaneous reactions in interferon treated patients is unknown.


The preoperative single-drug therapy did not affect the histological diagnosis or prevent the presence of an effective degree of tumor sensitivity to the drug.


Eight were treated with MB at a dose of 6 x 50 mg day(-1) intravenously (i.v.).


Granulocytopenia and agranulocytosis are considered among the most dangerous adverse effects of clozapine.


The study population included the affected patient (proband), nine of her blood relatives, and seven healthy volunteers.


No renal or cardiac toxicity was observed.


There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.


Focal glomerulonephritis and interstitial nephritis in methicillin-treated, heroin-related infective endocarditis.


Although a direct causal relationship between immunosuppression and lymphomatoid granulomatosis is lacking, the association of the two has been described.


Bilateral blindness after starting highly active antiretroviral treatment in a patient with HIV infection and cryptococcal meningitis.


After a latent period of 4 months, he developed a progressive, severe and ultimately fatal radiation myelopathy, which we suggest was due to a synergistic interaction between the high-dose chemotherapy and the radiotherapy.


Multibacillary, lepromatous or borderline leprosy patients may present two types of vasculonecrotic reactions: Lucio phenomenon and that associated with erythema nodosum leprosum.


However, id injection with monomeric Lex had no effect.


Naproxen, the most common offender, has been associated with a dimorphic clinical pattern: a PCT-like presentation and one simulating erythropoietic protoporphyria in the pediatric population.


METHODS: Retrospective review of a clinical case.


In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.


METHODS AND RESULTS: At 6 weeks after renal transplantation, a 57-year-old woman presented with TMA.


After 82 days' treatment her arm appeared normal and has remained so over seven months.


De novo hepatitis B virus (HBV) infection after orthotopic liver transplantation (OLT) always progresses to chronic hepatitis because of the patients' immunocompromised status, and only a few then acquire hepatitis B surface antigen (HBsAg) seroconversion even with efficient antiviral therapy.


The other author believes tympanoplasty should be performed prior to reconstruction (Dr.


Vancomycin is widely used against methicillin-resistant Staphylococcus aureus infections, but it is associated with many adverse effects such as nephrotoxicity, ototoxicity, gastrointestinal disturbances, blood disorders, and two types of hypersensitivity reactions - an anaphylactoid reaction known as "red man syndrome" and anaphylaxis.


Knowledge of the clinical picture is important for correct diagnosis and treatment.


Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described.


The principal types of renal disorders associated with chronic HCV infection are cryoglobulinemia or noncryoglobulinemic membranoproliferative glomerulonephritis (MPGN).


DISCUSSION: This preliminary clinical experience suggests that the addition of caspofungin to trimethoprim-sulfamethoxazole, which is active against trophic forms, may provide a synergistic activity against P. jiroveci by fully inhibiting the organism life cycle.


Ovarian endometrioid carcinoma and endometriosis developing in a postmenopausal breast cancer patient during tamoxifen therapy: a case report and review of the literature.


Since the depressive symptoms returned sertraline medication was initiated.


The absence of an obvious pelvic infection or nongynecologic etiology of the abscess made the case particularly unusual.


Six patients developed peripheral neuropathy and five patients bone marrow depression, blood transfusions were given to three patients and in all five patients bone marrow function normalized after cessation of linezolid.


Acute lymphoblastic leukemia as a second malignancy following the treatment of medulloblastoma is a very rare condition.


In this report, we present a case of hypoglycaemic coma associated with SP, an adverse reaction that is likely to be underreported and expected to occur with greater frequency as the use of SP increases.


Candida-induced denture stomatitis usually does not reflect any deep-seated, systemic abnormality, the dentures being the primary predisposing condition.


Magnetic resonance imaging (MRI) showed bilateral ischemic lesions of the globus pallidus, suggesting a generalized cerebral hypoxia during the comatose state as pathogenic mechanism.


Renal biopsy examination showed typical features of MN in all patients.


The infection did not recur.


He underwent the desensitization without incident on repeated infusions.


Thus, azithromycin was more effective but equally safe than ceftibuten in the initial therapy of pediatric CARTI.


The median interval from initiation of therapy to the development of leukemia is shortened from 54.2 to 41.1 months if radiation therapy is used in addition to chemotherapy.


EEG abnormalities were observed in two of the nine children during chlorambucil therapy.


On rare occasions, severe complications such as respiratory failure, metabolic acidosis, renal failure, coma, and death have been reported in both adults and children.


The potential arrhythmogenic effects of alcohol have recently been studied electrophysiologically.


Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.


This is probably the first report of drug-induced ego-dystonic, mood incongruent suicidal ideas appearing in a fully conscious, healthy individual.


Evaluation of hypothermia with psychiatric patients should include primary accidental hypothermia, central nervous system disorders, metabolic disorders, infections, and medications.


The taxonomical, pharmacological, and clinical aspects of angel's trumpet-induced disorders are discussed.


It has been reported that these atrophic areas remain unchanged and localized lipoatrophy may be preceded by a subcutaneous panniculitis.


Priapism is a rare disorder defined as a persistent penile erection that continues hours beyond, or is unrelated to, sexual stimulation.


Corneal edema resolves if sufficient endothelial cell viability is still present after resolution of ushaar keratitis.


The authors report the first case involving trapped epidural air in the spine that mimicked a mass lesion and caused neurological symptoms after epidural corticosteroid injection in the lumbar region.


Venous access devices (VAD) have become an important tool in the management of patients with cancer.


Two patients became culture-negative for S. oslo on treatment with this combination.


A response to rhEPO was defined as an increase in hematocrit of 4 percentage points or more over baseline, or the elimination of all transfusions with the hematocrit stable at the baseline level.


Diagnosis had been delayed secondary to sampling of the other uterine horn.


Oseltamivir appears to play an important role in the outcome of INFVA infection as well in URTI as in severe LRTI in patients receiving BMT.


Results at 3 months an open-prospectus study of 30 cases and review of the literature.


BACKGROUND: The safety of topical epinephrine (1:1000 concentration) has recently been called into question.


On day 23 of varenicline therapy, he received and filled a new prescription for amphetamine-dextroamphetamine and resumed his prescribed dosage (30 mg twice/day).


Secondary leukemia in a child with neuroblastoma while on oral etoposide: what is the cause?


Skin rash involved regions of the face, lower abdomen, back, buttocks and both upper thighs.


Seven years after the transplantation, cholelithiasis, cholecystitis, cholangitis and subsequently secondary chronic biliary sclerosis were detected.


The overall symptomatology of these patients as rated on the Brief Psychiatric Rating Scale (BPRS) decreased significantly from a mean of 57.0 +/- 10.4 to a mean of 37.8 +/- 7.7 (t = 7.03, df = 14, P = .001).


Teicoplanin-induced agranulocytosis that followed vancomycin-induced agranulocytosis suggests a possible cross-reactivity between the 2 drugs.


Intracameral injection of tPA seems to be a safe and effective method for the treatment of unresolved total hyphema.


L-asparaginase, an enzyme with established antileukemic activity, increases the induction rate and duration of remission of acute lymphoblastic leukemia when added to vincristine and prednisone for induction therapy.


In India, traditional therapy with herbal preparation (Ayurvedic medicine) is not uncommon.


Poison oak and related hypersensitivity dermatitides are age-old problems that have historically been treated with herbal medicines before the availability of corticosteroids.


The vitreous body of an eviscerated eye was occupied by the non-specific granulomatous tissue, composed of fibroblast, plasma cells, and Sudan black staining positive foamy cells, including melaniferous phagocytes, identified as CD 68 positive macrophage.


An antinociceptive effect of sumatriptan can be observed in SAH patients in good clinical condition, which suggests a specific craniovascular antinociceptive action.


Failure to recognize it and discontinue the offending agents may result in unnecessary morbidity and occasionally, irreversible renal failure.


Investigations revealed AT deficiency, thrombocytopenia and renal infarction.


Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report.


In situ hybridization identified Epstein-Barr virus latency-associated RNA expression in these cells.


There was no enhancement of the cyst wall and no pericystic oedema.


The anesthetic area conformed to the distribution of a specific nerve, the transverse cervical cutaneous nerve.


Cardiac transplantation is a well defined therapy for end stage heart failure.


Clinically, this condition presents with the classic triad of fever, rash, and lymphadenopathy.


She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer.


Skin-prick tests were performed for the antibiotics he received earlier in the day and the cyclosporine.


BACKGROUND: Bone marrow transplantation (BMT) is a common treatment used for deficiencies of host marrow or in the control of blood malignancies.


Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.


Seventeen days earlier, she had received a prescription for topical econazole lotion 1% to be applied 3 times daily for 1 month to treat a dermatitis affecting 12% of the body surface.


We have seen a case of terminal malignant melanoma in which clinical manifestations, indicative of anterior spinal artery syndrome, developed following the injection of 0.3 ml of 10% phenol-glycerine into the cervical subarachnoid space at the C4--C5 level for the control of severe right arm pain.


On the other hand, 13 patients had no histologically verified liver cirrhosis in their latest biopsy, and PIIINP was within the normal range in all 11 patients investigated, this in spite of total cumulative MTX doses from 1,120 to 18,645 mg (mean 7,171 mg).


After a total of 11 applications the patient developed a port thrombosis resistant to lysis with urokinase.


However, the child vomited when a cumulative dose of 315 mg was reached.


All patients had abnormal counts.


Circulatory arrest ensued.


It was concluded that mitoxantrone-cyclophosphamide is an effective chemotherapeutic combination with minimal toxicity and should be further studied in larger controlled trials.


Successful challenge with clozapine in a history of eosinophilia.


The mutations on the phenylalanine hydroxylase gene indicated that she might be responsive to tetrahydrobiopterin therapy.


SETTING: A university-affiliated teaching hospital.


METHODS: All admission records and operative reports, as well as available office notes, on patients with blebitis or bleb-associated endophthalmitis admitted to a large referral eye center from 1985 to 1995 were reviewed retrospectively.


P. carinii pneumonia (PCP) is usually a late complication in patients receiving TMP/SMX prophylaxis, with most cases occurring later than 2 months post-transplant.


The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.


In the 1st patient, clinical improvement occurred despite continuation of therapy, and in the 2nd the treatment was stopped with remission and rechallenge resulting in recurrence.


UL97 genotyping was carried out on peripheral blood samples, using a nested in-house PCR, which amplified the full-length UL97 gene.


Bone marrow transplant nephropathy (BMTN) classically presents more than 100 days after transplantation as an acute nephritis with hypertension, azotaemia and anemia that usually results in end stage renal failure (ESRF).


We report the resolution of all the features of PHS with systemic corticosteroids and recurrence on withdrawal, and further remission on reinstitution of systemic corticosteroids.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE.


We review the published data as well as the current treatment recommendations.


With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking.


CONCLUSION: Significant ocular complications such as an irreversible decrease of visual acuity may develop in patients treated with pegylated interferon.


An angiogram was performed, which demonstrated that the mass was fed by the branches from the right external carotid artery.


This case report of fulminant ADEM treated successfully with early high-dose intravenous methylprednisolone, although uncontrolled, suggests that this agent should be studied in other cases.


Intravitreal sustained-release ganciclovir implants for severe bilateral cytomegalovirus retinitis after stem cell transplantation.


Histological changes were consistent with IgA-nephropathy and focal segmental glomerulosclerosis.


There was no clinical or laboratory evidence for an immunologic or toxic insult, although in 1 patient we found a transient leukocyturia and mild proteinuria.


Pyridoxine for neonatal seizures: an unexpected danger.


The two final patients suffered from typical forms of primary NH, one associated with migraine without aura, the other with chronic tension-type headache.


Hyperkalaemia is a life-threatening electrolyte disorder that can occur in the first week of life in almost 50% of preterm infants with a birth weight less than 1000 g [extremely low birth weight (ELBW)].


They are also underdiagnosed and undertreated.


BACKGROUND: Coagulation disorders can cause intracerebral bleeding that may be difficult to detect since subsequent aberrant clot formation may mask early detection.


We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.


Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.


CASE REPORT: A 37-year-old white female patient admitted with epigastric pain and heartburn symptoms.


These effects were maintained for the remainder of the patient's chemotherapy protocol.


Thirty minutes after an anti-drug administration through the chest drainage tube, he lost consciousness shortly after coughing.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Broncho-pulmonary infection in a 50-year-old male with acute, hypertensive, intracerebral bleeding, necessitated therapy with cefpirome (2 g/day, 6 days), ciprofloxacin (800 mg/d, 11 days) and tazobactam/piperacillin (9 g/day, 11 days).


We present a brief review of the mechanism of action of TNF-alpha antagonists and their ability to predispose to various infections including viral pneumonia by interfering with the immune response.


They conclude that the vascular surgeon should be aware of this possibility and that oral anticoagulants should be used very carefully in the "medical" management of cholesterol embolization.


The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.


At 8 months after surgery, hair again covered his entire head.


Spontaneous coronary artery dissection is an unusual cause of acute myocardial ischemia.


In both cases there was a progressive increase during treatment, in peripheral blood lymphocyte counts, skin reactions and in vitro cellular responses to PPD, and a sudden rise in ESR at the time of their deterioration.


Tiny black granules were most numerous in the basal laminae of vessels in electron microscopic observation.


An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol.


Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.


Drug-induced agranulocytosis during treatment with infliximab in enteropathic spondyloarthropathy.


Dental and gingival pain as side effects of niacin therapy.


Cultures from the site of corneal abscess and vitreous grew coagulase-negative Staphylococcus.


Acute asymptomatic hepatitis in a healthy normal volunteer exposed to 2 oral doses of amodiaquine and artesunate.


Complications of encephalitis of unknown origin were successfully treated with steroid therapy and the patient has been in CR for 16 months after BMT.


In one patient after three tablets of Mexase a clioquinol concentration of 12 microgram/ml in plasma was found 24 hours after the specified dose, which is an unexpectedly high concentration compared to those reported as late as 24 hours after a single equal dose of Mexase or any other clioquinol-containing preparation.


Adverse effects of propafenone after long-term therapy with the addition of citalopram.


Torsades de pointes was diagnosed in the Emergency Department (ED).


We report the case of a young HIV seropositive patient with severe hemophilia A who presented rapid liver failure related to his chronic C hepatitis.


Acute dystonia with thalamic and brainstem lesions after initial penicillamine treatment in Wilson's disease.


Following 7 days of tigecycline she developed severe abdominal pain and elevated pancreatic enzymes suggesting acute pancreatitis.


Seizures and transient blindness following intravenous pulse methylprednisolone in children with primary glomerulonephritis.


Subsequently, he developed hyperglycemia (fasting blood glucose 138 mg/dL) that resolved when olanzapine was stopped and recurred (fasting blood glucose 150 mg/dL) after 2 days of rechallenge with olanzapine 2.5 mg twice daily.


Severe symptomatic hyponatremia during sibutramine therapy: a case report.


There are a few case reports of other fluoroquinolones that have been associated with toxic epidermal necrolysis.


CONCLUSIONS: Mycobacterial keratitis is a potentially vision-threatening complication after LASIK, characterized by a long latent period, delayed diagnosis, and a protracted course even under intensive specific antibiotic therapy.


A positive rechallenge occurred in seven cases (20%).


Furthermore, the concomitant use of fluoxetine and clozapine is discouraged, with citalopram suggested as a suitable antidepressant in those depressed patients receiving clozapine.


Based on these properties, GIRK activators have been suggested as candidates for antiepileptic drug development.


One twin had clinically appreciable hypoparathyroidism and had received calcitriol since early infancy.


Obidoxime was reinstituted after the 9 d interruption and muscle strength improved with the first dose.


A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression.


Early-onset acute transverse myelitis following hepatitis B vaccination and respiratory infection: case report.


Corticosteroid management of airway hemangiomas: long-term follow-up.


We have reported the first case of successful treatment of disseminated histoplasmosis in a renal allograft recipient using a short course (14 days) of amphotericin B in combination with prolonged therapy (161 days) with ketoconazole.


Two children, one with renal manifestations of systemic lupus erythematosus and the other with idiopathic nephrotic syndrome, were treated with methylprednisolone pulses.


A 64-year-old woman with blepharospasm, sustained clenching of the jaw, antecollis, and a strained, high-pitched phonation continued chronic trihexyphenidyl therapy despite the lack of any obvious benefit.


He developed hyperpyrexia with oligohidrosis and central neurological symptoms, including, chorea-like involuntary movements, resting tremor, and cogwheel rigidity.


Phenytoin toxicity and thyroid dysfunction.


Even though the pathogenic mechanism of acute leukemia after cytotoxic treatment is not known, the possibility must be considered that the incidence of this malignant disease is increased after cytotoxic treatment for nonmalignant diseases.


Seven months after treatment onset, a combination of nortriptyline, clonazepam, and relaxation procedures has successfully controlled the patient's facial pain symptoms.


False positive results due to cross-reactive compounds in drug assays may lead to misdiagnosis and mismanagement, especially when child abuse is suspected.


The intensive care unit (ICU) represents a dynamic interaction between patient factors and interventional factors.


A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).


This report describes our experience with four adult patients who suffered anthracycline extravasation and were treated with a regimen of ice, local glucocorticoid injection, and dimethylsulfoxide (DMSO) 55%-99% applied topically every 2-4 h after extravasation for a minimum of 3 days.


Thiazolidinedione drugs are in widespread use for the treatment of type 2 diabetes.


RESULTS: Bimatoprost was discontinued and diclofenac initiated.


He recovered after administration of anti-histamines and steroids.


With many HIV-infected patients surviving alkylator and topoisomerase inhibitor-based treatment and radiation therapy for AIDS-defining cancers and NADCs, long-term follow-up for therapy-related complications assumes greater importance.


Diagnosis of lipoid pneumonia was made by diagnostic bronchoscopy with bronchoalveolar lavage (BAL).


Terlipressin was discontinued, and the patient's QTc interval subsequently returned to baseline.


The chemotherapeutics, including vincristine, actinomycin D, and epirubicin in case 1 and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed.


The evidence for this mechanism is not convincing.


Four months later, she continued to exhibit decreased fluency and dysarthria with ataxia.


The time course of events suggested that amphotericin B was the cause of the seizures in this AIDS patient.


We report a case of symphysitis causing hospitalization and severe pain and discomfort of the patient.


The uncontrolled case report: a double-edged sword.


At five years of age elevated serum and urinary androgen levels unsuppressible with dexamethasone were noted.


The mechanism by which sunitinib induces gynaecomastia is thought to be associated with an unknown direct action on breast hormonal receptors.


This case and others indicate that caution should be exercised in administering IFN because low doses can be correlated with myasthenia gravis in patients without malignancies.


Primary ovarian large B-cell lymphoma in patient with juvenile rheumatoid arthritis treated with low dose Methotrexate.


Her serum creatinine was elevated to 2.2 mg/dl (baseline 1.5 mg/dl), and trough tacrolimus level was markedly elevated (> 30 ng/ml).


A 67 year old man presented to his local dentist for restorative treatment.


Finally a renal biopsy was performed and it showed a pauci-immunologic glomerulonephritis and the bronchioloalveolar lavage confirmed the diffuse alveolar hemorrhage.


Liver biopsy showed bridging hepatocellular necrosis as well as canalicular cholestasis.


Patients typically have surgical rhinoplasty to correct unsightly noses resulting from trauma, surgery, or heredity.


With the immunocompromised patient it is important to seek early ophthalmologic consultation when even minor ocular symptoms develop.


Antipsychotic-induced RLS and PLMS are not well-recognized side effects of antipsychotics, with the symptoms often misdiagnosed as psychotic agitation.


Because of the presence of severe ascites and massive ovarian enlargement, it was elected to treat this patient with methotrexate therapy rather than surgery.


The diagnosis of destructive thyroiditis was confirmed by anti-TSH receptor antibody (TSHRAb) negativity and the absence of radionuclide ((123)I or (99)Tc) uptake on thyroid scintiscans.


The second patient, a 39-year-old man, showed endophthalmitis of the right eye.


Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.


OBJECTIVE: To report a case of Carbamazepine toxicity following the administration of Oxybutynin and Dantrolene.


OBJECTIVES: Successful excision of the mass and identification of the causative agent by histologic and microbiologic studies.


Trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome associated with reactivation of human herpesvirus-6.


A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.


Methamphetamine's extensive physiologic effects, inconsistent street purity, and multiple routes of administration offer many possibilities for injury to the cornea.


A 66 year old HIV infected male heavy smoker presented with arthralgia, myalgia, and weight loss which was originally ascribed to nucleoside induced mitochondrial toxicity.


The optimal management of anthracycline extravasation remains unclear.


We describe a 66-year-old woman with chronic paranoid schizophrenia who was prescribed olanzapine along with several other psychiatric drugs and an antihypertensive drug.


Our report highlights the importance of taking a detailed occupational history and considering lead poisoning in the differential diagnosis of acute abdominal colic of unclear cause.


The patient recovered well after surgical drainage and antimicrobial therapy.


Hypotension and sinus arrest with nifedipine in pulmonary hypertension.


We report an example of ACC and review the relevant literature.


The lactic acidosis occurred in the absence of mitochondrial myopathy, hepatomegaly, or liver failure.


This article demonstrates that POS may be a useful drug in mucormycosis in children.


STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.


To increase the drug concentration at the infection site, we irrigated the capsular bag with antibiotics.


OBJECTIVE: To describe and discuss the use of continuous intravenous infusions of haloperidol to treat severe delirium and agitation in 3 intensive care unit (ICU) patients.


OBJECTIVE: To describe a case of exacerbated mania potentially related to an interaction between lopinavir/ritonavir and valproic acid (VPA) and propose a mechanism of action for this interaction.


Emphasis is placed on the significance of the possible relationship and similarity between NIS and catatonic stupor, and on the theoretical possibilities which this offers.


Scleral buckling and pars plana vitrectomy reattached the retina.


Post-PCI fatal bleeding in aspirin and clopidogrel hyper responder: shifting from antiplatelet resistance to bleeding risk assessment?


Of the 33 cases of bleb-associated endophthalmitis, there were 6 cases of early endophthalmitis (before postoperative week 6) and 27 cases of late endophthalmitis.


Nocardia asteroides peritonitis during continuous ambulatory peritoneal dialysis.


Calciphylaxis is a rare and life-threatening condition of progressive cutaneous necrosis secondary to small and medium-sized vessel calcification that is seen almost exclusively in patients with end-stage renal disease and hyperparathyroidism.


Aminoglycoside renal mineral wasting has not previously been described in a child.


Response rate did not appear to be influenced by age, sex, etiology, initial blood count, interval prior to ATG therapy, or dose of ATG employed.


RESULTS: A 30-year-old woman with polycystic ovary syndrome developed bilateral anterior uveitis during ovulation induction therapy.


This pattern is suggestive of renal toxicity due to tobramycin.


A review of causes of thrombocytoses in humans and animals is presented, and the criteria for diagnosis of essential thrombocythemia are examined.


This report describes two patients who developed acute myelocytic leukemia only after exposure to cyclophosphamide, methotrexate, and 5-fluorouracil adjuvant therapy.


We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).


Suicide associated with corticosteroid use during chemotherapy: case report.


Life-threatening hyponatremia caused by vinblastine.


Clinicians should be aware of the possibility of psychotic symptoms with the use of this agent.


The patient received the interferon for four months.


RESULTS: Five of the six patients experienced intolerable exacerbation of parkinsonism.


Central nervous system effects that parallel amnesia have been reported in 10-15% of the patients, including dizziness, ataxia, drowsiness, fatigue, confusion, and paranoia.


CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.


Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.


Blood level monitoring helps to determine the therapeutic and toxic ranges for anticonvulsants and antidepressants.


Orbital cellulitis after faden operation on the medial rectus.


A case report and review of the literature.


We present an AIDS patient with severe and prolonged lactic acidosis on stavudine and lamivudine.


Her past history suggested a congenital bleeding disorder.


These 4 cases are the first to be recorded in infancy, and with histopathological proof of fat embolism.


This syndrome has been associated with the use of aromatic ring-containing agents such as phenytoin, carbamazepine, or phenobarbitone.


Successful use of levosimendan in a patient during cardiopulmonary bypass.


Alprazolam withdrawal delirium unresponsive to diazepam: case report.


Bone Marrow Transplantation (2000) 25, 213-215.


Caution is, therefore, needed to prevent undesired accumulation of TCA that may lead to protracted Cushing's syndrome.


Researchers and clinicians have made numerous suggestions for managing the various side effects, although there is currently no research to guide evidence-based practice.


This case illustrates that serious sight-threatening complications may occur after LASEK due to abuse of topical anesthetic agents.


Computed tomography revealed two lesions located in the occipital and left temporal area of the brain.


Colonic carcinoma after chemotherapy of Hodgkin's disease.


Zanamivir, a neuraminidase inhibitor, has shown promise as a drug to control influenza.


Our case suggests that the peripheral venous access was probably the portal of entry of the fungus.


Much of the existing data comes from the neurology literature regarding epilepsy.


Two patients with rheumatoid arthritis developed evidence of hepatotoxicity while receiving D-penicillamine.


Six months after the diagnosis of sarcoidosis, the patient was asymptomatic and a complete sustained response to hepatitis C was achieved.


Inflammatory myopathy has been associated with systemic inflammatory processes, endocrinopathies, malignancies and infections.


Early noninvasive neurovascular and neurometabolic imaging is very helpful in choosing candidates for this type of therapy.


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.