Lactic acidosis in the setting of antiretroviral therapy for the acquired immunodeficiency syndrome.


Recent insights in the pathophysiological mechanism of these foreign body infections have elucidated the difficulty of achieving successful treatment without device removal.


Two case reports are presented: the first with clozapine challenge after eosinophilia, the second under clozapine treatment and no previous haematological side effects.


The rarity of this association with these types of malignancy, together with possible mechanism, is discussed in a brief review of the literature.


Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation.


After seven months' continuous treatment for suspected tuberculosis with rifampicin and ethambutol a nine-year-old boy developed polyarthritis, rash and hepatitis in association with anti-native DNA antibodies and positive antinuclear factor.


Cytomegalovirus infection is a potentially fatal complication of treatment induced immunosuppression in patients with inflammatory bowel disease.


It is suggested that cholestyramine, by reducing vitamin D absorption, precipitated the rapid development of osteomalacia in this patient.


Tyrosine kinase inhibitors and solid tumours: case report and review of the literature.


Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.


The case is of interest for two reasons: it is very rare for a case of malignant osteopetrosis to survive until adulthood and to be aware of the potential dental and oral complications of the disorder.


Thus, haemodialysis using high-flux membranes is a feasible and effective therapeutic option for carbamazepine intoxication.


Stevens-Johnson syndrome and toxic epidermal necrolysis: consequence of treatment of an emerging pathogen.


Dermal side reactions to SSRI-drugs in these patients may be due to high activity in the serotonergic system at the dermal and epidermo-dermal junctional area rather than a hypersensitivity to the drug molecule itself.


There was some evidence of a delayed-type bone marrow toxicity.


A 10-year-old asthmatic boy began to suffer from urticarial rash and moderately severe bronchospasm after 8 weeks' treatment with disodium cromoglycate.


Many therapeutic modalities are available, and combinations may be required in a comprehensive treatment program.


CASE REPORTS: The first patient was an 86-year-old woman who had been treated with oral colchicine because of rheumatoid arthritis.


Discontinuation of mianserin resulted in recurrence of akathisia, while full amelioration of the symptoms of akathisia was noted when mianserin was reinstituted.


After six weeks of therapy, clinical symptoms had greatly improved and intercellular antibody levels had decreased from a titer of 5,120 to 160.


Chronic ergot toxicity presenting with bilateral external iliac artery dissection and lower extremity rest pain.


We report on a patient with subarachnoid haemorrhage who developed an acute life-threatening pseudo-obstruction of the colon, a variant of adynamic ileus, while being treated with intravenous nimodipine.


All patients had experienced multiple episodes of severe hypoglycaemia and had impaired awareness of hypoglycaemia.


Aquagenic pruritus responding to intermittent photochemotherapy.


The authors describe a 19-year-old girl with a history of recurrent late-onset, febrile cholangitis in whom persistent jaundice developed.


The diagnosis was confirmed by mycological examination including culture.


CONCLUSION: This report describes a case of a probable interaction between topical econazole lotion 1% and acenocoumarol that resulted in overanticoagulation and a life-threatening laryngeal hematoma in this elderly patient.


We recommend that serum Na+ be carefully monitored in patients started on lorcainide therapy, and extreme caution should be exercised in prescribing diuretics to patients with persistent hyponatremia.


The use of methotrexate for treatment of psoriasis in patients with HIV infection.


The radiographic and CT scan show the typical "tram line" intracranial calcifications.


Dopamine agonists are increasingly used in the treatment of Parkinson disease, but they may cause serious adverse effects.


Persistent cerebrospinal fluid leak is a known complication of intrathecal pump system insertion for drug delivery.


Three cases of severe psychotic pictures with only mild or completely missing vegetative symptoms after ingestion of angel's trumpet tea are reported.


Human T cell leukemia virus type 1 proviral DNA loads were reduced to undetectable levels in PBMC sampled 12 months after BMT.


Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.


Emerging school-based methodologies are discussed with recommendations for future efforts.


Serotonergic antidepressants and urinary incontinence.


Three hemodialyses were performed in the patient during the oliguric phase of the disease.


The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.


Successful intraoperative use of recombinant tissue plasminogen activator during liver transplantation complicated by massive intracardiac/pulmonary thrombosis.


All seven patients were receiving INH daily for tuberculosis (TB) prophylaxis.


DISCUSSION: To our knowledge, this is the first case report illustrating neuralgic amyotrophy triggered by exposure to the antibiotics vancomycin, tobramycin, and piperacillin/tazobactam.


The reason for this is discussed.


Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.


This case demonstrates that localized signs of a bowel perforation may be absent in patients administered corticosteroids, that these patients may present with unusual, remote findings, and that bowel perforation can produce cervical subcutaneous emphysema.


The mean age of onset is around puberty and boys suffer more commonly as they are more inclined to play video games.


Two weeks later, the patient went to a local emergency department after experiencing two brief syncopal episodes.


We report the case of an adult patient with acute lymphoblastic leukemia who presented with repeated transient ischemic attacks followed by a seizure during consolidation treatment with L-asparaginase.


However, it failed in 1 case requiring transabdominal transperitoneal closure of the fistula with an interposition of omentum.


On postoperative day 17, she demonstrated hyperkalaemia and metabolic acidosis; she was diagnosed to have hyperkalaemic distal RTA with aldosterone deficiency (type IV).


We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril.


These observations add to the literature on pro-arrhythmic effects of commonly used antiarrhythmic drugs.


This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.


He suddenly developed a fever (temperature, 38 degrees C) and severe lower back pain without apparent cause.


That review suggested that patients receiving anti-D IGIV be monitored for those and other potential complications of hemoglobinemia, particularly disseminated intravascular coagulation (DIC).


In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.


After operation they developed arterial hypotension that failed to respond to epinephrine (adrenaline) or dobutamine treatment.


Three years later, treatment with ampicillin caused another episode of cholestatic hepatitis with cholestasis and duct paucity on rebiopsy.


DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.


Marrow aplasia lasted for 4 and 10 days, peripheral neuropathy for 15 and 42 days, gastrointestinal toxicity for 3 and 5 days, and hypertension for 5 and 14 days.


This report suggests that careful monitoring of patients undergoing oral amiodarone loading is necessary.


Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.


Retinoic acid syndrome in acute promyelocytic leukemia.


Malignant hyperthermia: clinical course and metabolic changes in two patients.


Toxic effects were less severe than previously described: this may be attributable to relatively low doses of DCF or to precautions taken to prevent tumour lysis syndrome.


This article reviews case reports and clinical studies of thrombolysis during and shortly after CPR in order to estimate the risk of severe bleeding events caused by CPR in association with thrombolysis compared with CPR without thrombolysis.


The relationship between this complication and calcium antagonist therapy is discussed and therapeutic strategies are presented.


During her life the patient frequently presented catamenial MA attacks with an increasing frequency during pregnancy in particular in the second and third trimesters, and then during breast-feeding.


In view of limited therapeutic options for her progressive disease, a trial of fluorouracil 300 mg/m(2)/d continuous intravenous infusion over 5 days was initiated without any premedications.


Our case represents the second reported case that required surgical intervention for cure.


DATA SYNTHESIS: A 49-year-old man developed symptoms of severe psychosis concomitant with ciprofloxacin (250 mg bid) treatment.


The authors performed a literature search using PubMed and the search terms "gemcitabine" and "radiation recall" to find prior cases of radiation recall attributed to gemcitabine.


An oral multivitamin tablet was substituted instead.


Eighteen patients were given MMF for the following reasons: renal failure in nine (50%); treatment of acute rejection in three (16.6%); primary prophylaxis of rejection in five (27.7%); and CNI withdrawal in one (5.5%).


A case of subepidermal autoimmune blistering disease in an 86-year-old woman is reported.


MRI demonstrated an ischemic infarct in the right striatum.


The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.


Results of all studies for Cushing's syndrome were normal and remained so 1 year later.


The erythroid defect fully reversed after the drug was discontinued and could not be attributed to the patient's previously treated lung carcinoma.


This case suggests that, when TMP/SMX is combined with glipizide, patients should be closely monitored, especially those at high risk for hypoglycemia.


We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).


An aerobic exercise test demonstrated remarkable serum lactate elevation, which was attenuated by the administration of coenzyme Q10.


Massive pulmonary thromboembolism resulted in circulatory collapse.


While the true correlation remains unknown, allergic cross-reactivity may occur between sulfonamide antibiotics and non-antibiotics, such as loop diuretics.


Treatment of lithium-induced diabetes insipidus with amiloride.


Herpetic tracheobronchitis may be a commoner clinical syndrome than generally assumed.


The pigment may be a drug metabolite-protein complex chelated with calcium, or an insoluble minocycline-melanin complex.


CONCLUSION: This is the first report of keratitis caused by Nocardia exalbida.


Imatinib mesylate-related fatal acute hepatic failure in a patient with chronic myeloid leukaemia and chronic hepatitis B infection.


Patch testing with NSAIDs is useful for confirming clinical diagnoses of delayed hypersensitivity to these drugs.


Whether these drugs adversely affect hepatobiliary scans is unknown.


The child was treated with resin hemoperfusion (XAD-4) to reduce her serum chloramphenicol concentration.


We report on three cases wherein treatment of dexmedetomidine-induced bradycardia with i.v. glycopyrrolate (5.0 microg/kg) not only resulting in resolution of bradycardia but also resulting in an exaggerated increase of arterial blood pressure.


We suggest that the treatment of hypoglycaemia with 50% solution of dextrose is associated with a significant risk factor in those diabetic individuals who are either allergic or are receiving beta-adrenoreceptor blocking drugs.


The identification of the spider as a brown recluse and the location of the bite over the nerve's usual pathway strongly suggest that the venom was responsible for this complication.


Physical exam revealed a patient with aphasia, tremor, and an expressionless face, able to make eye contact and move all four extremities.


CONCLUSION: Our PCR analysis showed the presence of CMV-DNA within the cornea of the patient with corneal endotheliitis.


HMSN is diagnosed in most cases retrospectively, usually suggested by the observation of foot abnormalities or family history.


The clinical aspect of porphyria has been investigated, and it is well known that porphyrinogens such as estrogens and alcohol or other inducers of P450 isoenzymes exacerbate the porphyric state.


These findings are discussed in the context of the few previous reports and are particularly important for future genetic counselling.


Treatment was continued for 6 days, during which the dosage was progressively decreased, and the mare was discharged.


A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan.


Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease.


His complete remission was maintained with a nitrosourea, nitrogen mustard and methotrexate for 3 years.


Leishmaniasis: a rare cause of unexplained fever in a renal graft recipient.


Epoprostenol may be associated rarely with severe erythroderma.


A 12 year old patient with atrial flutter is presented, in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia.


CONCLUSION: Flecainide is an effective therapy for supraventricular tachycardias in a twin pregnancy.


This was initially diagnosed as a spreading dental infection.


A case of Kaposi's sarcoma following treatment of membranoproliferative glomerulonephritis and a review of the literature.


Serotonin syndrome caused by interaction between citalopram and fentanyl.


Moreover, when the deficit is recognized the epidural itself may be falsely blamed for postoperative paraplegia.


The need for open-lung biopsy in patients with classic manifestations of LAM is also questioned, especially with the advent of high-resolution CT scanning, the nonspecificity of hormonal receptors with regard to response to therapy, and the possible need for subsequent lung transplantation.


Three patients were weaned from the VADs, and two survived.


Brain MRI showed restricted diffusion in the rostral midbrain and temporal and parietal lobes but not in the pons.


Cessation of MTX therapy led to complete regression of the tumor.


Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.


This was postulated to be due to the tacrolimus therapy, which was withdrawn.


METHODS: The investigation included inhalation challenge with the suspected compound combined with monitoring of lung function tests and post-challenge bronchoalveolar lavage.


A 21-year-old woman suffering from bipolar affective disorder developed systemic lupus erythematosus (SLE) with characteristic laboratory findings, 18 months after starting carbamazepine maintenance treatment.


Schizophrenia-like psychosis caused by a metabolic disorder.


OBJECTIVE: To report a case of phenolphthalein-induced toxic epidermal necrolysis (TEN) in a patient maintained on several other medications more commonly known to be associated with TEN.


Sixteen patients with widely metastatic cancer of the breast, including one man, received mitoxantrone, 10 mg/m2 intravenously (IV) over 30 minutes on day 1, followed by cyclophosphamide, 200 mg/m2 by mouth (PO) daily in divided doses on days 3 to 6.


Sirolimus-associated pneumonitis has been described in renal transplant patients.


Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin.


In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations.


DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.


Fibrosis of corpus cavernosum after intracavernous injection of phentolamine/papaverine.


CONCLUSION: It is important to maintain an awareness for the possible association between HIV lipodystrophy and symptomatic epidural lipomatosis.


At 37 weeks of gestation, she spontaneously delivered a healthy male baby.


Owing to suspected acute myocardial infarction, the patient was treated with thrombolytic therapy but her condition deteriorated.


The findings from transbronchial lung biopsy and bronchoalveolar lavage (BAL) were consistent with an organizing diffuse alveolar damage pattern.


Herbal medicine induced Stevens-Johnson syndrome: a case report.


All these resolved on reducing the dosage of cyclosporin.


A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).


We report on a 30-year-old man with metastatic non seminomatous germ cell tumor of the left testicle to the abdomen and the lungs, who suddenly developed a bilateral spontaneous pneumothorax after the first course of salvage chemotherapy.


Serum gadolinium levels were measured 1 hour after the gadolinium administration, then at 24 and 48 hours after PD was initiated.


Therefore repetitive clinical muscle power tests, that often are complicated by painful myalgia and activation potentiation, can be replaced by recordings of CMAP in the introduction and clinical follow up of cholinergic drug treatment in LEMS.


RESULTS: Withdrawal of oral colchicine therapy was followed by rapid corneal wound healing in both patients.


Nonconvulsive status epilepticus due to ifosfamide.


Two days prior to admission, metoclopramide 10 mg orally three times per day was started for a gastrointestinal condition.


Lansoprazole-associated collagenous colitis: a case report.


In this communication, six such melanoma cases are reported.


We describe a technique for 'single-pass' shunt tunneling from frontal to abdominal incisions and our initial results in a consecutive, prospective series of 15 children (age 2 days to 5 years).


Plasma atenolol levels decreased from 7.4 mg/L to 2.1 mg/L although significant rebound occurred between dialyses.


CASE SUMMARY: A 78-year-old white man presented with intractable lower back pain and constipation.


The platelet count increased to 355000/mm3 on the 15th day.


Best-corrected visual acuity was 6/60 in both eyes.


A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement.


CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.


This observation suggests that transient suppression of both cellular and humoral immunity may trigger viral reactivation, which leads to the development of the second phase of DIHS.


We describe a 61-year-old woman with "broken heart syndrome" (Takotsubo-like cardiomyopathy) after abrupt postsurgical withdrawal of OxyContin.


The patient, a 28-year-old man suffering from panic disorder, developed several first-rank symptoms during fluvoxamine administration.


Target Hct/Hgbs were attained and exceeded, although iron indices were not fully achieved.


The patient experienced hallucinations, agitation, vomiting, tachycardia and seizures after ingestion of 1050 (48 mg/kg) of extended-release bupropion.


Percutaneous radiofrequency thermal ablation (RFA) is considered an effective technique for providing local control in the majority of Hepatocellular carcinoma (HCC) patients.


Further investigation into the utility and safety of dual therapy with an ACE inhibitor plus an ARB in pediatric patients is warranted.


Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.


Baclofen for chronic hiccups.


Catecholamine-induced automaticity was one of the possible mechanisms of VT in the first case, but the mechanism is unknown in the second case.


Hepatocellular carcinoma (HCC) is increasing in numbers worldwide, and no effective systemic treatment existed for advanced HCC until SHARP (Sorafenib in HCC Assessment Randomized Protocol) study proved sorafenib (Nexavar((R)), Bayer Pharmaceuticals, Wayne, NJ, USA) prolonged survival versus placebo.


DISCUSSION: Since no other cause could be identified, liver injury was considered to be drug related.


In order to evaluate whether this rise in lactate could have occurred without requiring additional net lactic acid production, the effect of the hydrogen ion concentration on lactate distribution was evaluated.


In one of the patients, the hyperkalemia was associated with a fatal cardiac arrhythmia.


Fulminant liver failure associated with clarithromycin.


Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.


We report the case of a 40-year-old woman who developed fulminant hepatic failure and aplastic anaemia following a course of oral flucloxacillin.


This is the first report of a disulfiram-like reaction with cefmenoxime.


METHODS: We evaluated all neonates who received prostaglandin E1 in our hospital between October 1, 1989, and September 30, 1991, for clinical, radiologic, or pathological evidence of acute gastric-outlet obstruction.


AIM: To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).


The characteristics of insulin antibody in this patient were similar to the antibodies of IAS patients, therefore we administered oral glucocorticoid against insulin antibody.


Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.


On that occasion, routine laboratory tests, including a complete blood count, blood chemistry and liver function tests, were within normal limits.


LDEs can clinically and histologically resemble idiopathic or classic lichen planus.


Blood counts returned to normal 6 days after institution of granulocyte colony stimulating factor therapy.


The MRI showed marked vascularity and neovascularity of the tumor.


DISCUSSION: Half were treated with topical imiquimod.


Loss of seizure control associated with generic substitution of carbamazepine.


She continued taking verapamil for 6 months, then, on her own, stopped all medications including the sustained-release verapamil, and her asthma symptoms disappeared.


The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


During hemoperfusion a mean clearance of chloramphenicol of 27.4 ml/min was achieved.


Headache induced by acute exposure to a specific drug constitutes an idiosyncratic side effect.


Rapamycin/sirolimus (SR), trade named Rapammune (Wyeth-Ayerst, Sydney, Australia), is a potent immunosuppressive drug associated with myelosuppression, hypertension, hyperlipidemia, and infection.


This case illustrated that 'maqianzi' can cause strychnine poisoning even after processing, especially when the recommended dose is greatly exceeded.


The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.


An angiogram showed a thrombus cranial to the screw.


Increasing warfarin dosage reductions associated with concurrent warfarin and repeated cycles of 5-Fluorouracil therapy.


Nonoliguric acute renal failure after captopril therapy.


IFN-beta-1b therapy was then resumed, and the patient is in remission for both nephrotic syndrome and MS.


Our first patient developed rippling muscles about 1 month after infection with Yersinia enterocolitica.


Her course was complicated by pneumonia, barotrauma, and atelectasis accompanying her moribund state.


It is comprised by pain, discoloration, and edema in the vicinity of intravenous infusion of phenytoin through dorsal veins of the hand.


Plasma exchange in selected patients with juvenile rheumatoid arthritis.


In early 1983, an outbreak of illness caused by raw milk contaminated with multiple-antimicrobial-resistant Salmonella typhimurium occurred in Arizona.


Clinical profile of oxcarbazepine-related angioneurotic edema: case report and review.


We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.


Laboratory studies showed leukocyturia, thrombocytopenia, severe anemia, and tarry stools.


We suspected an opiate-induced suppression of the hypothalamus-pituitary-adrenal (HPA) axis.


We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.


Neuropathy is a significant side effect of thalidomide therapy, which may limit its clinical use.


One patient was symptomatic and the other had only electrocardiographic changes.


Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped.


Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.


Several therapeutic and dietary manipulations failed to control these symptoms in previous reports as well as in an infant we have followed after Nissen fundoplication.


Cimetidine-induced fever.


Hydroxychloroquine (HCQ) is an antimalarial agent with immunomodulatory effects.


Lithium intoxication: a report of two cases.


Investigations suggested that the dextrose, rather than any additives, was responsible for the reaction.


One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).


Successful repair of myocardial free wall rupture after thrombolytic therapy for acute infarction.


Coincident with this therapy, the blood lactate concentration rose from 21 to 27 mmole/L.


The pulmonary infiltration and clinical symptoms subsided after withdrawal of all drugs and initiation of glucocorticoid therapy.


Steroid rosacea is a facial dermatitis clinically resembling acne rosacea.


Histologic evaluation showed massive panlobular necrosis.


It is possible that 5-HT2 antagonism is essential for therapeutic benefit in this condition.


In addition, we suggest that der(17)t(12;17)(q13;p13) should be considered a new recurrent, nonrandom chromosomal abnormality in patients with t-MDS/AML.


Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.


Interferon-based treatments have the potential to decrease the burden of disease, but are complicated by side effects, including neuropsychiatric symptoms.


Ticlopidine-induced aplastic anemia (TIAA) is considered very uncommon.


Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.


SSRI-drugs increase serotonin concentrations and are known to have pruritus and other dermal side effects.


A 44-year-old man was admitted for disturbance of consciousness caused by progressive hydrocephalus.


The authors present a case of acute postoperative paralysis after posterior cervical decompression by a mechanism that has not yet been reported in the literature.


Bulbar and pseudobulbar palsy complicating therapy with high-dose cytosine arabinoside in children with leukemia.


Here, we present illustrative case histories to educate the reader on evaluation and management of this complex syndrome.


The platelet count was 221000/mm3, decreased 42% from the initial level, but remained within the normal range.


We present a patient with human immunodeficiency virus infection under treatment with foscarnet for CMV retinitis who complained of thirst and polyuria.


A transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials in quinine toxicity, to our knowledge, have not been previously reported.


In most European recommendations, the empirical antibiotic treatment is directed against "the most likely pathogen," based on epidemiological, clinical, and laboratory data, and on the severity of illness.


Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy.


Administration of clonazepam reduced the frequency and amplitude.


Pathological examination on multiple uterine sections showed the absence of residual tumor cells in the uterus.


All three children are still disease-free, after a mean follow-up period of 42 months.


RESULTS: The patient tolerated this fairly well and has been on this treatment and regular diet for >1 year, without any adverse reaction.


As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.


A 5-year-old girl was admitted due to severe asthmatic attack.


Foci of retinochoroiditis were observed unilaterally in three patients and bilaterally in one.


RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.


Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.


Whitish papules on the palm.


Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects.


A case report is presented of an antenatally diagnosed fetal goiter induced by antithyroid medications.


Numerous oral complications have been documented as a consequence of chemotherapy for the treatment of cancer.


Addition of over-the-counter medications, herbal products, vitamins, or dietary changes was denied.


Intravenous ganciclovir was started and continued for 3 weeks.


L-T4 stimulated lymphocyte transformation in this patient.


The presentation can be varied depending on severity.


Sequential therapeutic trials with intraarterial 5-fluorouracil, intraarterial adriamycin, and intravenous 1,3 bis[2-chloroethyl]-1-nitrosourea (BCNU) were unsuccesful.


Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate, prednisone, and asparaginase.


This drug has been used for treatment of human malaria since 1984, and to date clinical trials have involved about 3.4 million patients in more than 30 countries (personal communication).


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described.


The tumor subsequently spread to involve skin of the forearm and arm.


We hypothesize that decreased renal elimination of MTX induced by the COX-2 inhibitor resulted in enhanced hematopoietic toxicity and immunosuppression causing the EBV-associated lymphoproliferative disease.


A drug interaction between zafirlukast and theophylline.


The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.


Emergence of Philadelphia positive chronic myeloid leukaemia during treatment with hydroxyurea for Philadelphia negative essential thrombocythaemia.


Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.


Photodynamic therapy and intravitreal triamcinolone were used in an 84-year-old man with choroidal neovascularization in the left eye.


Serologic HIV was negative and HHV8 viremia was under the limit of quantitation of the assay.


CONCLUSION: These new targeted agents result in unique cutaneous toxicities.


GCV-resistance during VCV-prophylaxis was rare after renal transplantation.


Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor.


Side effects were managed by temporary discontinuation of gold until side effects resolved and resumption of treatment using usually 50% lower dosage.


Type B lactic acidosis, a rare but often fatal disorder, has been reported in 21 AIDS patients on antiretroviral therapy (ART).


The subsequent conditioning regimen included busulfan 16 mg/kg, Ara-C 12 g/m2 and melphalan 140 mg/m2.


Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report.


Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization.


This patient's ectropion and facial eczema may have been confounded by ocular rosacea.


We studied this drug in a continuous ambulatory peritoneal dialysis (CAPD) and immunocompromised patient.


Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.


The patient's high CMV-DNA viral load became undetectable on leflunomide and foscarnet, but the patient, who had severe graft-versus-host disease (GVHD) of the liver, expired with progressive liver failure and other complications.


The first patient developed mild nitritoid symptoms and pain in a band-like distribution, corresponding to T10-T12 dermatomes, shortly after gold sodium thiomalate (GSTM) injection.


Caution with use of cimetidine in tolazoline induced upper gastrointestinal bleeding.


We do not know why these differences occur.


There are few aids to diagnosis but once it is known that the patient has been on practolol the surgical and pathological findings are pathognomonic.


The morphologic findings of group 1 biopsies were those of autoimmune hepatitis in all 4 patients.


Atypical facial pain or neuralgia and lower-half headache are confusing terms and should be discarded.


Selective serotonin reuptake inhibitors and benzodiazepines appear to be the most common pharmacologic treatment approaches.


First, he received salazosulphapyridine (SASP) as treatment for the UC.


He was transfused with 3 units of packed red blood cells.


In a phase II study of hycanthone in patients with breast cancer we have recently observed severe hepatotoxicity, even at lower doses, which resulted in two drug-related deaths.


Corneal calcifications are presumably related to longer-lasting phosphate application.


Insulin-induced lipoatrophy in type I diabetes.


But when corticosteroid eyedrops were added, there was a recurrence of the keratitis.


This case illustrates that distortion-product otoacoustic emissions (DPOAEs) may be an appropriate cross-check measure to supplement and confirm pediatric behavioral data.


Subphrenic abscess secondary to Actinomycosis meyeri and Klebsiella ozaenae following laparoscopic cholecystectomy.


Further research into the mechanism of IFN related cutaneous side effects is needed.


A patient with complex regional pain syndrome type I of the left upper extremity was scheduled for left stellate ganglion block with the anterior paratracheal approach under fluoroscopy.


The patient had a long history of constipation with daily use of mineral oil.


A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.


Clinical features suggested that the lesion was an ischemic infarct, and this was confirmed by an MRI scan.


Patient 2, a 24-month-old girl, was asymptomatic during the first days after the accident; subsequently, she started to cough and developed fever, dyspnea and chest pain.


Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.


Posterior leukoencephalopathy syndromes have been reported with hypertension, and immunosuppressive and chemotherapy agents.


CBC revealed pancytopenia.


DISCUSSION: Toxic epidermal necrolysis is an infrequent, yet often fatal, severe, systemic, cutaneous disease most often the result of an adverse drug reaction.


Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab (R-EPOCH) for diffuse large B-cell lymphoma.


Special attention should be paid to symptoms of pulmonary thromboembolism in patients after spinal surgery.


Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.


METHODS: 33-year old man with bilateral nonrhegmatogenous retinal detachment, misdiagnosed as uveitis, iatrogenically treated with systemic corticosteroids.


Acute respiratory failure precipitated by a carbonic anhydrase inhibitor.


CONCLUSIONS: This report indicates clindamycin phosphate vaginal cream as the most probable cause of CDIC due to the temporal relationship between the occurrence of diarrhea and clindamycin administration, lack of concomitant medications, and documentation of C. difficile toxin.


Traditionally, charcoal haemoperfusion is used to remove the drug.


A case of gouty arthritis following percutaneous radiofrequency ablation for hepatocellular carcinoma.


Recently lamivudine has been reported to be effective in suppressing the replication of HBV under such conditions.


Administration of cation-exchange resin such as sodium polystyrene sulphonate (Kayexalate) is effective in lowering plasma potassium, although complications following oral or rectal administration are reported in newborns.


Pipotiazine palmitate, a long acting drug, indeed: a case report.


Miconazole a new antifungal agent was used with dramatic response.


There are few references of allergic reaction to this hormone.


The patient underwent a total hysterectomy and bilateral salpingo-oophorectomy with multiple omental biopsies.


Methotrexate may rarely provoke serositis, even with low doses and after just a few weeks of therapy.


Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.


Although hypophosphatemia induced by aluminum-containing antacids is rare, treatment of peptic ulcer disease with a combination of two aluminum-containing agents may increase the risk of clinically significant hypophosphatemia.


Acute gastrointestinal bleeding following aortic valve replacement in a patient with Heyde's sindrome.


A 52-year-old, white female developed low-grade fever, cough, and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis.


The present report is of a 67-year-old woman presenting with bulky cervicothoracic RIF who, 10 years previously, had received radiochemotherapy for a small cell thyroid carcinoma to a dose of 50 Gy, with severe acute side-effects.


Its pharmacological manipulation invariably impacts at multiple molecular sites.


In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.


The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.


The symptoms disappeared with clemastine and betametasone treatment.


1 previously untreated patient with plasma-cell leukaemia and 8 patients with myeloma (4 previously untreated) were treated with high-dose melphalan 100-140 mg/m2 iv.


She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity.


Emergent operative re-exploration confirmed these findings; large, swollen paraspinal muscles, a functioning drain, and no hematoma were found.


One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity.


Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.


A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described.


The purpose of this study was to evaluate the neuroprotective effect of MB in these patients and to review the literature.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


Thyrotropin-producing pituitary adenoma associated with Graves' disease.


Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.


Nystatin was ineffective.


We describe two such cases manifesting at different times during the course of primary hypothyroidism.


A mini-review of the literature based on a MEDLINE search follows.


TMJ symptoms improved after the first bilateral intra-articular infliximab injections but even more so after the second injections.


Drugs are a major cause of this disease, and the list of culprits is continually expanding.


Five days after beginning continuous ambulatory peritoneal dialysis (CAPD) he developed an eosinophilic peritonitis (EP).


However, it has not been reported as a cause of peritonitis.


A low frequency, high amplitude rhythmic fluctuation of laser-Doppler skin blood flow after subarachnoid phenol block.


Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis.


However, if the increment is severe and producing symptoms, withdrawing the probable causative drug is warranted.


Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.


Conventional brachytherapy can reduce these problems, but its use is limited in young children because of radiation exposure to parents and care-givers.


A 25-year-old woman with mild hyperphenylalaninemia due to a PAH mutation of IVS12nt1g-->a/E390G has been treated for 1 year with BH4 therapy.


METHODS: Report of two cases.


She had received 18 courses six years earlier without incident.


Heterotopic intrauterine and tubal pregnancy complicated by pulmonary embolism.


DESIGN: Case report.


Appropriate investigations ruled out any organic cause of the fits and clozapine was successfully restarted, together with sodium valproate.


After a three-week interval of remission, relapse occurred.


Primary invasive aspergillosis of the gut is a rare event and is associated with high mortality.


The activity of dihydropyrimidine dehydrogenase (DPD), the initial enzyme of pyrimidine (and FUra) catabolism, in peripheral blood mononuclear cells was measured in each subject by a specific radiometric assay using FUra as the substrate.


Thrombocytopenia with or without microangiopathy following quinine is often referred to as quinine "hypersensitivity." When schistocytes are present it is frequently termed "quinine-associated TTP/HUS." A severe deficiency of the vWF-cleaving protease, ADAMTS13, is associated with idiopathic TTP.


Unfortunately, they have a number of important side effects including the potentiation or exacerbation of metabolic acidosis.


A 39 year old white male with a 55% total body surface burn who developed neuroleptic malignant syndrome (NMS) during his acute course is reported.


After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.


Granulocyte macrophage-colony-stimulating factor (GM-CSF) has shown promise as a means of alleviating leukopenia associated with a wide variety of disorders.


The neurological symptoms resolved completely within 72 h.


The patient was urged to undergo tooth extractions because of alveolar pyorrhea, and a low-dosage intravenous immunoglobulin (IV-Ig) therapy (0.3 g of IgG/kg/day for 3 days) was chosen for him.


Eight months after the initiation of therapy he developed fatigue and dyspnea on exertion.


Therefore, we conclude that chronic hepatitis C patients, especially people with darkly pigmented skin, need to be closely monitored for ophthalmologic complications, by periodic check-up of the optic fundi, for a prolonged period, during interferon treatment.


We describe a case of symptomatic hypophosphataemia following an intra-articular glucocorticoid injection.


Both patients were successfully treated by chemotherapy including all-trans retinoic acid (ATRA), and after reaching complete remission, they have subsequently been in continuous remission.


We report a case of hyponatremia associated with a grand mal seizure in a 28 month-old child after intra-nasal desmopressin administration for high fluid intake with nocturnal enuresis.


A diode laser was used as an effective and safe method to remove the patient's overgrown gingival tissue.


She had received repeated chemotherapy, irradiation of the left lung, autologous and allogeneic bone marrow transplantation (BMT), and segmentectomy of the base of the left lung as treatments for Hodgkin's lymphoma.


We report on 7 patients (2 women, 5 men) with chronic renal failure, who developed under a high dosage of the new diuretic muzolimine (range 240 to 1440 mg per day) fatal neuromyeloencephalopathy.


METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


Initially, the mental changes were thought to be related to the operation.


It usually is given by bolus intravenous injection, sometimes in high doses (> 5 mg), even though that is not approved by the Food and Drug Administration.


In this article, a patient with EBV-lymphoma after autologous stem cell rescue for treatment of a nonhematologic solid tumor is described.


Ultrastructural evaluation were also performed in selected cases.


A case report.


Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.


Some hours later she became unresponsive with little respiratory effort.


In 3 patients, the syndrome was exacerbated after conversion of therapy to another antiepileptic drug with an aromatic ring chemical structure.


It has been proposed that the elevated serum uric acid levels are linked to other risk factors, such as hypertension, dyslipidaemia and diabetes.


INTRODUCTION: The clinical pattern of corneal calcification has been considered to be a part of chronic eye diseases, such as uveitis, severe glaucoma, keratitis and eye burns.


Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.


Amphotericin B (AmB) is effective, but its use is limited by toxicity: renal impairment, anaemia, fever, malaise, and hypokalaemia are common.


Motor milestones are slightly retarded--neurodevelopment is otherwise normal.


One hour after she drank the second bowl of herbal decoction, she suddenly developed tonic contractions of all her limb muscles and carpopedal spasm lasting 5 min, difficulty in breathing, chest discomfort and perioral numbness.


PURPOSE: Considerations in selecting antithrombotic and antiplatelet therapy for patients with non-ST-segment elevation (NSTE) acute coronary syndrome (ACS), including patients undergoing percutaneous coronary intervention (PCI), are discussed, and case studies are used to illustrate.


Drug interactions between Ritonavir and Tacrolimus should be anticipated.


Therefore, COX-2 inhibitors should be used with caution in renal transplant recipients and in patients with salt depletion and renal insufficiency.


A 13-year-old girl with acute lymphocytic leukemia was treated according to the protocol of the BFM Group (BFM-95, HRG).


Acute lymphoblastic leukemia in a patient with chronic cyanoacrylate exposure.


Both octreotide and the PPAR gamma receptor-activating ligands, thiazolidinediones, may be effective for patients with TSHoma.


BACKGROUND: Propafenone, a class IC antiarrhythmic, and citalopram, a selective serotonin reuptake inhibitor (SSRI), are widely used in older patients.


We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.


MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.


Lithium is known to cause acute renal failure and tubulo-interstitial disease, but the recently described association with proteinuria or nephrotic syndrome is little recognized.


Combination disease modifying antirheumatic drug therapy was common, with 82/171 (48.0%) taking methotrexate (MTX), 15/171 (8.8%) hydroxy-chloroquine, 11/171 (6.4%) sulfasalazine, and 8/171 (4.7%) anti-tumor necrosis factor therapy.


Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


Such an occurrence presents a difficult challenge because cardiac function is compromised, the coagulation profile may be altered, the cerebral hematoma is life threatening, and intracranial hemostasis is difficult to achieve.


Effect of azithromycin on bronchiectasis and pulmonary function in a heart-lung transplant patient with severe chronic allograft dysfunction: a case report.


A 64-year-old male patient developed progressive pancytopenia three weeks into therapy with lenalidomide for his relapsed MM.


OBJECTIVE: To describe the management of tumor lysis syndrome (TLS) with rasburicase in 2 patients who presented with cancer within the first month of life and compare and contrast both cases with respect to their underlying renal physiology, management, and eventual outcome.


The case illustrates the prolonged clinical course of echoviral meningitis in a patient receiving cytotoxic drug therapy, and it suggests that factor(s) other than humoral antibodies may be involved in the elimination of echovirus from the central nervous system.


Photo-onycholysis may follow the use of various medications or may occasionally be idiopathic.


CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.


On the 6th post-procedural day, the patient complained of new right knee pain.


We describe the clinical response, as determined by increases in total Hb and decreased transfusion needs, in five patients with thalassemia intermedia treated with HU alone or in combination with SPB.


Two of the four patients with pseudomembranous colitis did not promptly respond to therapy, and all four suffered significant further immobilization because of the disease.


Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.


The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.


Pulmonary tuberculosis in a child receiving intensive chemotherapy for acute myeloblastic leukemia.


Bronchoalveolar lavage (BAL) may be used to rule out infectious etiologies, and an increase in BAL fluid eosinophils is suggestive of drug-induced toxicity.


Information was reviewed for three of 538 volunteers who received PEG-rHuMGDF in clinical trials and two of 200 donors who underwent G-CSF mobilised stem cell harvesting procedures for sibling stem cell transplants.


Because there is no increased prevalence of PCNSL in MS, and the patient was otherwise not immunocompromised, an association between natalizumab therapy and PCNSL cannot be ruled out.


Two patients bled.


We describe the case of a patient with a clinically silent left-sided nasofrontal dermoid cyst who, while being treated with hCG/LH for hypogonadotropic hypogonadism, presented with simple partial seizures, ipsilateral to the cyst, with secondary generalization.


Recently, ketorolac was demonstrated to relieve pain in RSD patients when administered by intravenous regional block (IVRB), yet this method has obvious limitations in the outpatient setting.


L. micdadei PVE successfully treated with levofloxacin/valve replacement: case report and review of the literature.


Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.


OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.


Consideration of the use of heliox may provide another option for the treatment of a patient suffering from refractory bronchospasm.


A patient with idiopathic thrombocytopenia purpura who was treated with high dosage corticosteroids for ten years, developed 18 separate lesions of avascular necrosis in 12 different bones.


The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.


At surgery, the only significant findings were that the coeliac lymph nodes were enlarged and stained purplish black as were the omentum and the intraperitoneal fat.


Also, adverse effects and other treatment problems from the experience of continuous treatment of 19 LEMS patients with 3,4-DAP for up to 10 years are presented.


Surgical treatment included debridement (6), grafting (2), digit amputation (1), digit dermotomy (1), and fasciotomy (1).


We report a case of fatal adenovirus infection in a 37-year-old female who underwent allogeneic bone marrow transplantation (BMT) for acute myelogenous leukaemia (AML).


This case emphasizes the importance of renal prostagandins in the control of vascular tone and sodium homeostasis.


DESIGN: Retrospective interventional case series.


One patient required nursing home placement and a feeding gastrostomy as a result of the worsening parkinsonism during risperidone treatment, but was able to return home and have the gastrostomy removed after switching from risperidone to clozapine.


The third patient had lower limb chronic venous insufficiency and developed extensive necrosis of both lower limbs.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


Abrupt, accidental withdrawal of trihexyphenidyl triggered severe exacerbation of the cranial dystonia associated with inspiratory stridor and acute respiratory difficulties, prompting emergency admission.


This case of linezolid-associated acute interstitial nephritis within the context of a drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in a patient treated with linezolid raises concerns about the presumed renal safety of this drug.


When obstruction occurs due to antacid concretions, it may be relieved by passing a long intestinal tube, by giving enemas for colonic obstruction or by operation.


Histologic examination also revealed multiple shallow ulcers accompanied by cytomegalovirus infection.


Prolonged use of large intravenous steroid pulses in the rheumatic diseases of children.


Impaired absorption or accelerated elimination might explain these results.


The patient in this report had long standing RA treated with MTX and had recently begun taking a cyclooxygenase-2 (COX-2) inhibitor.


Families and physicians need to have an increased awareness of this possibility and of the appropriate management of myoglobinuria.


Diagnosis of Churg-Strauss syndrome was confirmed both by characteristic clinical features and by histology.


An adverse reaction to the acute administration of sublingual nifedipine is reported.


These 4 cases are the first to be recorded in infancy, and with histopathological proof of fat embolism.


We sought to evaluate the etiology of the long QT syndrome in these patients without previously identified causes for QT, prolongation, and determine the prevalence among patients with HIV infection.


A case report.


A worsening of ritualistic behavior was noted, and the clomipramine dosage was increased to 150 mg/d over 14 days.


A transverse spinal cord syndrome occurred due to a pathological fracture of C5 and C6 and operative decompression was necessary.


The three unilateral cases evolved favorably, but the bilateral case, seen late, showed extensive macular scarring.


Conventional antipsychotics have little efficacy against negative symptoms, and so many patients with schizophrenia are refractory to treatment with these drugs.


Patients have the right to adequate and safe pain relief in hospitals, but many continue to experience unrelieved pain.


These symptoms recurred following 2 subsequent administrations of metoclopramide.


Antibiotic treatment combined with surgical and radiological interventions resulted in full recovery.


His polymyoclonus was successfully treated with phenytoin, sodium thiopental infusion, sodium valproate and supportive care of the hemodynamic, and respiratory systems.


Persisent ocular hypertension following intravitreal ranibizumab.


The incidence, cause, and mechanism of such a side effect are unknown but should be considered in patients receiving high-dose carmustine infusions.


Shortly after hepatic artery clamping the patient developed a massive intracardiac/intravascular thrombosis that resulted in cardiac arrest.


The delayed encephalopathy developed 9 and 22 months respectively after the first dose of intrathecal methotrexate.


CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.


The patients who developed neurotoxicity had markedly higher global ratings of psychotic symptomatology and anxiety in the pretoxic period than did patients who never deveoped neurotoxicity.


However, all three patients eventually died of refractory acidosis.


Neutropenic enterocolitis or typhlitis (from the Greek typhlon, meaning caecum) is defined as a necrotizing colitis with inflammation of the cecum and surrounding tissues.


Eighty-two percent of patients had clinical and laboratory improvement on the higher or maintenance dose of corticosteroids.


Ptosis occurring 24 h after chloroquine therapy, with full recovery 48 h after cessation of chloroquine, has not been described previously.


In these patients, it might be more adequate to start mirtazapine therapy at a lower dose (<15 mg/d).


Choroidal hemorrhage associated with systemic tissue plasminogen activator.


This is the first case in the literature--to the best of our knowledge--describing a minimally invasive strategy using CT fluoroscopic guidance to perform an injection of thrombin into the perfused pseudoaneurysm to seal a leakage.


Lymphangiomyomatosis: hormonal implications in etiology and therapy.


Huge prosthetic mitral valve thrombus: use of serial transesophageal echocardiography guidance in resolution.


Theoretically the link could be in a disturbance of serine and glycine metabolism.


METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.


Silent acute myocardial infarction following a wasp sting.


Coagulation parameters of 3 different time-points were assessed and compared: before administration of any blood product (time-point 1), before administration of the first dose of rFVIIa (time-point 2), and 4 hours after the administration of the last dose of rFVIIa (time-point 3).


We report a case of cerebral arterial air embolism that was followed by a brain computed tomographic scan and magnetic resonance imaging during the first week after onset.


In contrast, a partial recovery of the Arden ratio of the EOG to 1.8 in both eyes was seen.


The increase of tumor volume at the beginning of therapy does not require the suspension of treatment.


The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.


INTRODUCTION: Cetuximab is a chimeric antibody registered for the therapy of advanced colorectal carcinoma after failure of standard chemotherapy.


Three-months after implantation of the intravenous access device, the indwelling central catheter was fractured and embolized to the pulmonary trunk.


Although both the spontaneous occurrence of SLE and the psychosis as a sign of CNS involvement of SLE cannot be excluded, SLE could be considered as an adverse effect of carbamazepine.


Drug induced polymyositis secondary to leuprolide acetate (Lupron) therapy for prostate carcinoma.


Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide.


Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.


At this psychiatrist visit, sertraline 50 mg/day was added for her depression, and was continued after a geriatrician visit in October.


This set of findings is similar to the acute inflammatory stimulation observed with exposure to irritants, and may lead to mucus obstruction of small airways and increased nasal resistance.


Her medical history included vascular dementia accompanied by depression, arterial hypertension, and heart failure, as well as cardiac pacemaker implantation several years earlier for severe bradyarrythmia.


A woman with a 20-year history of acral pustular psoriasis of Hallopeau and recurrent pustular lesions of the forearms and lower legs, developed a B-cell lymphoma of the lip following 4 1/2 years of treatment with razoxane.


CONCLUSIONS: Intracerebral hemorrhage must be strongly suspected in any patient with a coagulation disorder presenting with matching clinical symptoms.


The clinical relevance of HHV-6 infections in cancer patients undergoing conventional cytotoxic therapy is undetermined, however.


Severe loss of vision after removal of cataract caused by intravitreal triamcinolone in combination with photodynamic therapy for exudative age-related macular degeneration.


Endoscopy demonstrated dimpling of the gastric mucosa on the anterior wall of the stomach.


In view of previous reports that SIADH and limbic encephalitis are caused by reactivation of latent herpesviruses after transplantation, both conditions may be secondarily caused by reactivation of latent herpesviruses, which is typically observed in DIHS/DRESS.


CLINICAL PRESENTATION: Spine pain may precede neurologic deterioration by many hours.


Although some of these agents can improve cardiovascular disease risk in patients with diabetes, others may increase the risk and may be prohibited from use in certain populations.


This report may serve to remind EEG'ers and epileptologists that the acute use of this drug may be effective in dealing with PLEDs that are often difficult to eliminate.


The chromosomal abnormality der(17)t(12;17)(q13;p13) is very rare in hematologic malignancies, and has been reported in only two patients with therapy-related acute myeloid leukemia (t-AML).


Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis.


It is believed that this is the first reported case of reversible azathioprine-induced cholestasis associated with histological evidence of bile duct injury.


Throughout approximately 3 years of treatment with these erythropoietin analogs, the patient's total daily dose of insulin was reduced in response to his decreasing A1C values, despite elevated blood glucose levels and the absence of patient-reported hypoglycemic events.


Early recognition and aggressive treatment are necessary for patient survival.


Albendazole is an antibiotic that is chemically related to metronidazole.


Safety of thrombolysis during cardiopulmonary resuscitation.


He was diagnosed with a viral syndrome, acetaminophen was prescribed, and he was sent home.


Gemcitabine is a chemotherapy agent that may cause unpredictable side effects.


Four adolescents who used St.


Increased vigilance is always advised when administering drugs not commonly given to pediatric patients.


She was 37 years old at the time of initial diagnosis.


The diagnosis of DIHS was made based on the patient's history of using an offending drug, clinical manifestations and laboratory data showing peripheral eosinophilia with the presence of atypical lymphocytes.


Extravasation injury is a common event in pediatric intensive-care units.


Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura.


Combination chemotherapy with VM 26 and CCNU is well tolerated and can be administered on an out-patient basis.


A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin.


Our results suggest that topiramate titration should be performed gradually, so as not to neglect cases responsive to low doses.


He presented with confusion and focal seizures with a rapid progression to coma and decerebrate posturing.


Microangiopathic hemolytic anemia in a patient with recurrent anal cancer and liver metastasis.


However, the medical literature now contains at least 125 other detailed reports of ANLL developing after prolonged cytotoxic agent therapy.


Surprisingly, insulin therapy had to be suspended because of hypoglycemic fits and treatment with metformin was started.


Treatments can be given on an outpatient basis, without requiring prolonged patient sedation or immobilization.


Her management consisted of regular blood transfusions aimed at haemoglobin above 8.5 g/dl, antimicrobials, oxymetholone, low dose prednisone and folate.


Recently, combined chemotherapy and radiation therapy has been introduced for head and neck tumours.


Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.


The most common presenting findings were somnolence-lethargy (96%), miosis (56%), and respiratory depression (48%), a paradoxical hypertensive response (44%) was more common than expected.


BACKGROUND: Back pain is a common presentation associated with opioid seeking behaviour.


However, in 1993, a clinical study involving 400 patients on the Thai-Burmese border revealed cardiac effects of antimalarial treatment with halofantrine, including one sudden death after the treatment.


Her blood chemistry indicated AST 342 IU/L, ALT 356 IU/L, and hyaluronic acid 255 ng/mL.


Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal.


Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.


A 19-year-old man with untreated systemic lupus erythematosus had an acute myocardial infarction.


Rapid progression to fatal postnecrotic cirrhosis.


Possible precipitating factors were damage to the subclavian vein, congestive heart failure, paroxysmal atrial fibrillation, and immobilization.


Combined pharmacomechanical thrombectomy for acute inferior vena cava filter thrombosis.


Preinjection visual acuity measured 20/80.


His chemotherapy consisted of doxorubicin HCL, bleomycin, dacarbazine, and vinblastine, with prophylactic administration of a granulocyte colony stimulating factor.


The patient experienced over a 10-month period, signs and symptoms suggestive of metabolic toxicity marked by bouts of gastrointestinal distress, low-grade fever, incoordination, and disorientation.


Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure.


Ideally, the ostium is treated by positioning the stent with a slight degree of overhang in the aorta to ensure coverage of the aorto-ostial junction.


However, its use has recently been limited because of adverse cutaneous and hepatic effects.


There have been several reported cases of omeprazole-induced AIN.


Cutaneous malignant melanoma after immunosuppressive therapy.


Treatment with topical corticosteroids and avoidance of suspect irritants usually resolves the dermatitis.


Gabapentin toxicity in renal failure: the importance of dose adjustment.


The morbidity and lethality of AL amyloidosis is caused by the deposition of lg light chains as fibrillar amyloid protein in vital organs, disrupting their function, and not by the generally low burden of clonal plasma cells that produce the paraproteins.


An outbreak of multiple-drug-resistant Salmonella enteritis from raw milk.


Similar material was located in the major choroidal vessels.


It was confirmed that these dermatitis reactions were due to contact and/or photocontact allergy to psoralens by several methods that include patch and photopatch tests, photopatch test mapping, determination of the minimal erythema dose (MED) and immunohistochemistry.


The patient had been treated with four kinds of antihistamines and antiallergenic drugs.


On further questioning, the patient admitted to the daily use of mineral oil for constipation.


STUDY DESIGN: A case report is presented.


Systemic corticosteroids in the phenytoin hypersensitivity syndrome.


The dose was subsequently increased to 200 and 400 mg/day on alternate days, six days per week, and two months later AVT occurred.


Central nervous system (CNS) disturbances, reported in 12 patients, were the most common unwanted effects.


Several biopsies yielded a mold initially phenotypically identified as a Penicillium species, but molecular sequence analysis ultimately determined the identity as Paecilomyces lilacinus.


Microdeletions of 22q11.2 are the main etiology for DiGeorge syndrome, a disorder characterized by heart defects, immune deficiencies due to aplasia or hypoplasia of the thymus, and hypocalcemia.


However our case report demonstrates that early and aggressive treatment with haemofiltration can improve outcomes even in the presence of severe acidosis.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


A 63-year-old man with hypothyroidism is described.


Subfulminant syncytial giant cell hepatitis: recurrence after liver transplantation treated with ribavirin.


The use of bivalirudin alone is as effective and has been associated with less bleeding than the use of UFH or enoxaparin plus a glycoprotein (GP) IIb/ IIIa inhibitor in patients with NSTE ACS who undergo PCI.


The cat was admitted with acute respiratory distress, vomiting, and collapse, which began 15 to 20 minutes after topical application of the drug.


RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.


In 1992, some 90 countries or territories where 42% of the world's population resided were considered malarious and estimation of deaths from malaria worldwide per year were in the order of 1.4 of 2.8 million.


Morphine, an opium alkaloid, frequently causes side effects such as hyperhidrosis and facial flushing, but serious cutaneous adverse drug reactions are seldom observed.


Survivors of childhood solid tumors including Ewing sarcoma (ES) have an increased risk of secondary malignant neoplasms (SMNs) as a consequence of exposure to chemotherapy and/or radiation (see: Bhatia S, Sklar C.


The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.


Six isolated reports of prenatally exposed infants with various congenital anomalies exist, but to date no specific phenotype has been delineated.


At hospital discharge, platelet testing showed hyper response to antiplatelet therapy with very low post treatment platelet reactivity.


In four patients the maximum ST elevation was greater than or equal to 5 mm.


The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth.


The patients treated with bromocriptine at 7.5-15 mg/day adjunctive to l-dopa were selected to replace bromocriptine with pergolide of the equivalent dosage approved in Japan.


CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.


Successful treatment with arsenic trioxide of a patient with ATRA-resistant relapse of acute promyelocytic leukemia.


After diagnosis of epidural lipomatosis on magnetic resonance imaging, the patient underwent decompressive thoraco-laminectomy.


Uveitis during treatment of disseminated Mycobacterium avium-intracellulare complex infection with the combination of rifabutin, clarithromycin and ethambutol.


Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction.


A broad-spectrum antibiotic regimen included a penicillinase-resistant preparation because of the frequent involvement of Staphylococcus aureus.


Patients with cell-mediated immune defects are at higher risk for acquiring infections with Salmonella species.


An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.


The incidence of RS among children with juvenile rheumatoid arthritis is significantly greater than the incidence of RS among children who do not have juvenile rheumatoid arthritis.


A 55-year-old man developed acute myocardial infarction (AMI) related to a large coronary artery aneurysm and a distal coronary stenotic lesion after steroid therapy for systemic lupus erythematosus (SLE).


Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.


Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.


The skin was hard, shiny and hairless.


Corynebacterium striatum: a diphtheroid with pathogenic potential.


We report a case of a woman with ectopic pregnancy with fetal cardiac activity after ovulation induction and transvaginal intratubal insemination by tactile sensation.


Rapid improvement in muscle strength accompanied by prompt resolution of abnormal elevation of muscle enzymes followed cessation of both medications.


This case illustrates that PCR is a rapid technique for the early diagnosis of TA-GVHD.


Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.


As nephrotic-range proteinuria, hypoalbuminemia, and general edema were worsening even 2 weeks after cessation of the drug, oral corticosteroid therapy (prednisolone 40 mg/day) was started.


A 53-year-old woman presented with an extensively metastatic and rapidly growing breast adenocarcinoma, markedly elevated lactate dehydrogenase, and mildly elevated blood urea nitrogen.


The potential anticonvulsant effect of these drugs was successfully reversed by the administration of intravenous flumazenil just prior to the treatments.


The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.


Postrenal failure was excluded by echography.


Gynaecomastia due to anti-tubercular chemotherapy is a rare side effect.


Differential diagnoses included ocular rosacea with cicatrizing conjunctivitis and 5-FU-induced ectropion.


The patient developed severe ovarian hyperstimulation and became pregnant with an ectopic gestation after ovulation induction.


The use of plasma exchange in quinine-TMA is called into question.


Here, we will describe three episodes of NMS that fulfilled the DSM-IV criteria for NMS (APA, 1994).


Theophylline intoxication following viloxazine induced decrease in clearance.


Ocular motor and imaging abnormalities of midbrain dysfunction in osmotic demyelination syndrome.


CONCLUSION: Risperidone was an effective and safe treatment in three cases of delusions of infestation.


The standard treatment for late infections of knee prostheses is a two-stage reimplantation with a temporary articulating spacer between operations, but there is no universal agreement as to the best type of spacer to be used and surgeons have created modifications according to their technical and economic resources.


Upon analysis of plasma VWF multimers (VWFMs) in this patient, those with large to medium molecular masses more selectively disappeared before the IV-Ig infusion than did those with small molecular masses.


PURPOSE: The case of a patient who developed aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension simultaneously during treatment with trimethoprim-sulfamethoxazole is described.


A fibrinolytic therapy with recombinant tissue-type plasminogen activator according to the Neuhaus scheme was attempted.


The results of laboratory tests revealed elevated levels of hepatic enzymes, including alanine transaminase (ALT) and aspartate transaminase (AST).


The patient's medications had been stable for at least six months except for the addition of carbamazepine one month before his arrival at the ED.


We discuss other similar cases so physicians continue to be aware of this rare yet potentially life-threatening reaction to a commonly used medication.


DISCUSSION: Neonates may be at particular risk for TLS given their immature renal function and its predisposition toward metabolic derangements.


Moreover, she had changed her antiperspirant 1 week before the onset of the lesions.


Here we report on a patient with schizophrenia who suffered from medication-refractory coprophagia.


Otolaryngologists should be made aware of a newer cause of nasal septal perforations resulting from the more recent antiangiogenic therapy used to treat malignancies.


CASE SUMMARY: A 59-year-old man was diagnosed with squamous-cell carcinoma of the lung in T4N2M0 stage and treated with cisplatin, vinorelbine, and gemcitabine.


Carbamazepine induced right bundle branch block in a Greenlandic patient.


A 47-y-old female underwent revision of a left total hip replacement because of loose prosthesis.


Clozapine-induced akathisia in children with schizophrenia.


From this study and the previously available data, we conclude that this drug is too toxic for human trials at the currently recommended doses.


We also review evidence that the risk of this complication is substantially lower with the newer nonergot dopamine agonists.


Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.


That the drug was directly responsible for the observed complications is suggested by the clinical course and by in vitro lymphocyte transformation studies.


A renal tubular abnormality may have allowed the usually self-limiting acidosis of acetazolamide to progress.


A case is presented of a patient who experienced benzodiazepine withdrawal symptoms on discontinuation of nefazodone, an antidepressant that inhibits the cytochrome P450 3A4 isoenzyme.


A 28-y-old male with end stage renal failure (ESRF) received an overdose of atenolol.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Mycophenolate mofetil in a dose of 1.0-2.0 g/day was given in 2 patients with severe refractory myasthenia gravis and in 1 patient with myasthenia gravis-polymyositis syndrome.


He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.


Fourteen days of treatment with ganciclovir led to a prompt improvement in the symptoms of colitis, resolution of the pyrexia, normalisation of the liver function tests, and clearance of the virus, as measured by a negative cytomegalovirus DNA PCR.


Most asthma drugs are inhaled using various forms of inhalers or nebulizers.


A retrospective review of TTP patients with quinine-associated thrombotic microangiopathy (TMA) for whom ADAMTS13 was measured before plasma exchange was performed.


Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).


RESULTS: The injection demonstrated the block in the catheter.


Infants are particularly susceptible to chronic nitrate-induced methemoglobinemia because of their low stomach acid production, large numbers of nitrite-reducing bacteria, and the relatively easy oxidation of fetal hemoglobin.


Tacrolimus was substituted for cyclosporine on day 20; on day 21 amlodipine was initiated to manage hypertension.


Ceftriaxone was approved in 1997 for the treatment of otitis media despite previous studies that documented an association of ceftriaxone with elevated hepato-biliary enzymes and transient biliary stasis.


A 66-year-old pseudophakic man with primary open-angle glaucoma and ocular cicatricial pemphigoid underwent trabeculectomy and was given postoperative subconjunctival 5-fluorouracil.


Renal function gradually improved but nephrotic state was persistent.


The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).


Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.


Because the efficacy of the prophylactic use of lamivudine has been reported and the steroid enhances curability of malignant lymphoma, the steroid containing regimen with prophylaxis of lamivudine should be evaluated further.


OBJECTIVE: To investigate the mechanisms involved in hypersensitivity reactions to cyclosporine and determine the feasibility of future cyclosporine use.


Thus, perospirone is an agent with possible efficacy for medication-refractory schizophrenia.


His medical history was significant for 5-FU bolus injections for intestinal cancer since May 1998.


These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN).


Although retinoic acid is well tolerated by the majority of patients with this disease, a potentially fatal complication of this kind of treatment has been reported: "the retinoic acid syndrome".


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Protease inhibitor-associated angiolipomatosis.


Our case report suggests that posaconazole is an attractive treatment option in patients with peritoneal dialysis-related Mucor peritonitis.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


The two previously unreported adverse effects are a diffuse loss of color discrimination and an increased time course to complete dark adaptation.


Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.


CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.


The concentration of pseudoephedrine in blood and liver specimens was measured using gas chromatography-mass spectrometry and was determined to be 14.4 mg/L in the blood and 16 mg/kg in the liver.


Although current recommendations state that TZDs should not be administered to patients with New York Heart Association class III or IV disease, practitioners should be aware that these adverse effects also may occur in patients with milder forms heart failure as well as those without heart failure.


Ramipril was stopped and he required a course of steroids after which the rash improved slowly.


Obsessive-compulsive symptoms suddenly emerged 10 days after starting risperidone and resolved within 3 days of discontinuation.


Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?


PARTICIPANTS: Seven patients (eight patient visits) with an age range of 5 days to 14.9 years.


We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).


We also describe a new, noninvasive method to assess magnesium-induced neuromuscular block when curariform muscle relaxant was given simultaneously.


Resolution of the interface inflammation did not occur until intraocular pressure was controlled.


The discontinuation of heavy caffeine intake appears to have contributed to the outcome.


DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.


A postmortem toxicology analysis reported a fluoxetine concentration of 4500 mcg/L and diazepam of 500 mcg/L.


A correlation between dose and manifestation was investigated but none was found.


The overall response rate was 20%, and a further 40% achieved stable disease.


The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent.


Neutropenia and agranulocytosis are risks known to occur with phenothiazines and clozapine.


Clinical examination revealed 2 distinct corneal infiltrates beneath the LASIK flap.


However, electron microscopy disclosed focal mesangial interposition, irregular thickening of the glomerular basement membrane and subendothelial loosening.


This severe illness was likely caused by minocycline, and we speculate that minocycline may have acted as a superantigen, causing lymphocyte over-activation and massive cytokine release.


These findings support previous studies that showed that the use of aspirin during the antecedent illness may be a risk factor for the development of RS.


Although it is difficult to solely attribute intratumoral hemorrhage to aspirin, we have to be careful when prescribing aspirin for patients who have asymptomatic meningioma.


Pulmonary hemorrhage as a clinical manifestation of hemolytic-uremic syndrome associated with mitomycin C therapy.


Perforated appendicitis and ectopic pregnancy following in-vitro fertilization.


To our knowledge, this is the first such reported thrombotic event.


Fenofibrate administration is associated with a uric acid lowering effect.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.


METHODS: Skin prick test (SPT), nasal and intramuscular challenge test with commercial salmon calcitonin (Miacalcic) were performed.


Our case points to the need for increased awareness by the general pediatricians of the potential hazards of mineral oil use for chronic constipation.


We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.


Bronchial anthracostenosis with mediastinal fibrosis associated with long-term wood-smoke exposure.


Further investigation is needed to determine the scope of this troubling side effect.


Chest computed tomography showed the characteristic findings of septic pulmonary emboli (SPE).


Clonazepam for the treatment of lancinating phantom limb pain.


We report a patient who developed CD7+ therapy-related acute myeloid leukemia (t-AML) with trisomy 8 after chemotherapy for AML.


Both patients completed the planned course of radiotherapy without interruption, after administration of G-CSF.


Pemphigus foliaceus induced by rifampicin.


She developed pruritus, edema, and urticaria over both hands.


CONCLUSION: The increasing role of radiotherapy in nasopharyngeal carcinoma treatment, together with improved patient survival, is likely to lead to radiation-induced, secondary, space-occupying lesions being encountered more frequently.


Neurological side effects in two patients receiving gold injections for rheumatoid arthritis.


Estimation of maternal PIVKA levels may be of value for predicting risk of hemorrhage in the neonate.


Pulmonary oedema after hexoprenaline administration in preterm labour.


Three months after hospital discharge, the abdominal pain did not recur.


The focus of this case report is to create awareness within the clinician that, in addition to evaluating the patient for the disease related issues that may affect the oral cavity and dentition, a total management plan should include factors beyond the structural oral problems related to the cancer.


After therapy for diabetic coma with insulin (containing the preservative cresol) and electrolyte solutions was started, the patient complained of increasing myalgia, developed a high fever and respiratory and metabolic acidosis and lost consciousness.


A regimen of topical INF alpha 2-beta 4 times daily was administered.


On admission, high levels of arterial hypertension were found.


We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.


This regimen is administered in cycles of approximately 3 weeks; a total course of treatment consists of six cycles.


METHODS: Thirteen consecutive patients with unresectable multifocal HCC and resistance to TAE were treated with combination chemotherapy consisting of arterial chemoembolization with degradable starch microspheres (DSM) (150-4500 mg on Day 1), mitomycin-C (4-8 mg on Day 1), continuous arterial infusion of 5-fluorouracil (1250 mg/120 h), cisplatin (25-50 mg/120 h) and l-leucovorin (125 mg/120 h) for 10-19 weeks.


After 5 weeks of therapy, she stopped taking pantoprazole due to general malaise.


Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.


JHR is a self-limiting condition that warrants the continuation of antibiotic treatment in syphilis patients.


To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.


The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer.


Oxime therapy should be considered even late in the course of untreated or partially treated OP intoxications, especially when the etiologic agent is a lipid-soluble compound (ie malathion) that can cause a protracted course of poisoning.


It can progress rapidly to high fever, altered mental status, seizures, profound muscle rigidity, rhabdomyolysis, brain injury, and death.


The patient developed Leuconostoc bacteremia secondary to peritonitis, 60 d after undergoing liver transplantation.


There was no indication that the increase in anaphylactoid reactions was associated with the use of hyperthermia.


a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.


Although asymptomatic, the biochemical abnormality improved after discontinuation of carbamazepine.


Except for generalized cerebral gliosis, the abnormalities in the brain were confined to the cerebellum, where malformation of the dentate nuclei, neuronal heterotopias, and abnormalities of Purkinje's cell dendrites were found.


He gradually improved and his biochemical markers returned to normal.


These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.


The quality of life was assessed in 37 maintenance hemodialysis patients during treatment with recombinant human erythropoietin (r-HuEPO; EPOGEN [epoetin alfa], AMGEN Inc, Thousand Oaks, CA) for correction of anemia.


We conclude that intoxication with lacosamide, in combination with overdoses of multiple AEDs, can be survived without sequelae, even after ingestion of 12 g lacosamide.


Until additional data are available, if intravenous acyclovir is administered concurrently with lithium, we recommend closely monitoring patients for signs of lithium toxicity and measuring serum lithium levels every second or third day.


Although adverse effects are usually mild, the author reports here a case of leucocytopenia and thrombocytopenia with quetiapine treatment that required its discontinuation.


It is particularly important in the treatment of systemic lupus erythematosus (SLE) since it reduces new organ involvement and disease flares, and relieves skin and joint symptoms.


After unsuccessful therapy with ganciclovir and foscarnet, combined antiviral and anti-inflammatory treatment with cidofovir and prednisolone controlled the HHV-6 infection and enabled resolution of clinical symptoms.


A review of the literature, which yielded 23 other reports of endocarditis due to this organism, suggests that Lactobacillus is a rare cause of endocarditis.


Stupor and fast activity on electroencephalography in a child treated with valproate.


The patient was successfully treated with heparin and subsequently with warfarin and dipyridamole.


We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).


We report a patient with inoperable pancreatic cancer who developed gastrointestinal bleeding secondary to radiation-recall related to gemcitabine and review literature.


DESIGN: Case report.


Before onset of treatment, level of GABA in CSF was highly lowered (16 pmol/ml), pyridoxine level in serum was within normal range.


CASE REPORT: We present cases of 10 patients with Type 2 diabetes mellitus who developed acute renal failure and severe lactic acidosis.