This is the fourth published report of adverse hepatic reaction to cyproterone acetate and it substantiates other evidence that cyproterone acetate is potentially hepatotoxic.


We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.


Most patients (75%) developed the syndrome 6 to 12 months after starting chemotherapy, and 60% were in remission.


Effects of the two forms of pulse appear similar.


Pediatric heparin-induced thrombocytopenia: management with Danaparoid (orgaran).


Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine.


A novel approach to central venous catheter thrombosis in a patient with cystic fibrosis.


Transdermal scopolamine delivery system (TRANSDERM-V) and acute angle-closure glaucoma.


A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.


The patient's blood pressure decreased from a baseline of 130/80 mm Hg to 70/55 mm Hg, 39 minutes into the infusion.


Opioid drugs markedly delayed clearance of Tc-IDA from the common bile duct, simulating common bile duct obstruction.


Possible causes of this phenomenon are proposed keeping in mind that a hypotensive drug can cause intra ocular pressure rise.


In 98 patients in whom complex ventricular ectopy was controlled, there were 6 sudden deaths, that is, an annual mortality of 2.3 percent.


On the 16th day of therapy, however, relative eosinophilia developed, and 2 days later a pruritic maculopapular rash appeared.


The clinical, biochemical, and, finally, genetic evaluation confirmed Wilson's disease diagnosis in this patient.


Codeine intoxication in the neonate.


This case report illustrates that bronchiectasis may greatly improve after treatment with azithromycin and no longer needs to be considered an endstage finding in patients with severe BOS.


Acute cardiogenic pulmonary edema and other causes of respiratory distress were ruled out; diagnosis of Adult Respiratory Distress Syndrome (ARDS) was made.


These findings are related to those reported previously.


We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.


Adenosine-induced ventricular fibrillation.


Luke's-Roosevelt Hospital of the 4 study patients were reviewed and compared with those of 41 patients from a group of 537 patients concurrently admitted with a diagnosis of myocardial infarction (MI).


We report a case of cough following the administration of quinapril, with complete resolution after changing to the alternative ACE inhibitor fosinopril in a patient with essential hypertension.


CONCLUSION: Alendronate led to nodular scleritis and rechallenge caused recurrence of scleritis.


BK virus-associated nephropathy (BKVN) has become recognized as an important cause of allograft dysfunction among transplant recipients.


Clinical, laboratory (absence of others markers of hepatic disease), and histological findings seem to rule out common causes of hepatic disease.


Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.


Concomitant administration of lithium with olanzapine may place patients at risk for NMS.


Anaphylaxis to intrathecal diamorphine.


It is well known that intravascular injection of oleic acid induces acute respiratory failure in animal models.


DISCUSSION: Angiotensin-converting enzyme (ACE) inhibitors are associated with a relatively high incidence of angioedema.


Monitoring of the prothrombin time for cephalosporins or the bleeding time for moxalactam is the most reliable way to prevent what may be rapid emergence of clinical bleeding in patients with renal failure.


Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.


In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.


This phenotype is reminiscent of the Baller-Gerold syndrome.


In one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation.


She had received cumulative doses of cyclophosphamide 6000 mg, doxorubicin 420 mg, and vincristine 12 mg.


On day 7 of linezolid treatment, the patient developed severe pruritus, macular rash, facial edema, eosinophilia, marked increase in serum creatinine level, and mild hepatitis.


With this in mind, the authors present the case of a 32-year-old chronically institutionalized schizophrenic who showed a remarkable improvement in both tardive dyskinesia and psychotic symptoms following an open trial of clozapine, 900 mg daily.


Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.


In infants with sudded death or onset of cyanosis, appropriate toxicological and historical information should be obtained.


Topical capsaicin cream has been a beneficial adjuvant medication in the treatment of some painful conditions.


At the same time, this immune cell reaction triggers a greater granulomatous reaction.


She was patch tested to European Standard Series, including BP 1% in white petrolatum, and to the 10% BP-containing gel previously used by herself, showing positivity on day 2 to BP 1% and to the 10% BP-containing gel.


Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.


An appointment was made for the patient but he did not attend.


The authors present three patients with traumatic upper limb amputations where topical capsaicin cream was of benefit in the treatment of neurogenic residual limb pain.


Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.


After terminating the Partusisten medication, there was no effect on the fetal arrhythmia and flecainide therapy was initiated.


CONCLUSIONS: Imiquimod is a new and novel treatment option for cutaneous malignancies.


CYP2C19, which catalyses the metabolism of, for example, citalopram, clomipramine and moclobemide.


We report the first successful desensitization protocol to high-dose MTX.


Successful treatment of pacemaker related endocarditis with acute embolic stroke without device removal.


Mixed mania associated with tricyclic antidepressant therapy in prepubertal delusional depression: three cases.


The data obtained suggest the presence of acquired maturation abnormalities in the B cell compartment.


We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C).


Priapism associated with thrombophilia is a well-recognized entity.


About 44% of the patients had gastric adenocarcinoma, and 82% had received mitomycin C.


Histologic examination of tubular bones showed hyperostosis presumably due to prostaglandin-induced rapid formation of primitive bone.


The authors present an elderly patient with mixed dementia who developed TD at multiple sites, (including respiratory dyskinesia [RD], limb dyskinesia, and orofacial dyskinesia) following abrupt withdrawal of risperidone therapy.


Multiple pancreatic abscesses due to Candida albicans following ERCP.


Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD.


If these patients are switched to alternative levothyroxine products, it is recommended that thyroid function tests be repeated after equilibration to the new product.


BACKGROUND: Interferon (IFN)-associated retinopathy is typically characterized by retinal hemorrhages and cotton wool spots at the posterior fundus, but visual function is usually maintained.


It is a potentially serious reaction which is little influenced by which drug is injected.


The effect of potassium is reminiscent of its effect in the channelopathies underlying hypokalemic periodic paralysis, and the resistance to lidocaine applied peripherally suggests a peripheral sensory localization to the abnormality.


One of the most troublesome side effects of perfusion is peripheral nerve damage, which has been reported at a rate of between 1 and 48% of perfused patients.


Four weeks earlier she had developed hepatopathy during a regimen of carbamazepine, lynestrenol and sodium valproate.


OBJECTIVE: To report the clinical course of a woman with cryptococcal meningitis and no previous cardiac disease who developed a fatal cardiac arrhythmia after an acute overdose of amphotericin B and to review its toxicity.


PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.


The cerebral venous sinus thrombosis, involving cerebral veins, superior sagittal sinus and straight sinus, was diagnosed by cerebral angiography.


This case represented the acute tumor lysis syndrome that occurred after chemotherapy of breast carcinoma.


Spontaneous pneumothorax following chemotherapy for metastatic germ cell tumor: a case report.


We report the first biopsy confirmed occurrence of acute interstitial nephritis in a patient receiving treatment with Sunitinib for metastatic renal cell cancer.


The low frequency HAR wave persisted for the subsequent 3 months until a tingling sensation returned to the left leg.


Oral warfarin is the standard of care for patients requiring long-term anticoagulation due to venous thromboembolic disease.


RESULTS: Patient was found to have inferonasal nodular scleritis.


The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.


Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.


MRI also indicated improvement.


Abnormalities of the pupil and visual-evoked potential in quinine amblyopia.


Reperfusion was achieved by coronary thrombolytic therapy with urokinase.


RESULTS: A literature search of publication between 1999 and October 2008 retrieved 34 cases of hepatitis.


Transient hemiparesis caused by phenytoin toxicity.


Antibody therapy is capable of permanently abolishing the signs of symptoms of digitalis poisoning after a matter of hours.


A characteristic speech disorder, which may be described as cortical dysarthria or speech apraxia, occurs in approximately 1% of adults undergoing OLT.


Removal of gadolinium by peritoneal dialysis.


After 2 months, visual acuity and ocular hyperemia returned to baseline levels.


This case suggests that highly angiogenic tumours such as angiosarcoma may be effectively palliated using agents usually reserved for refractory Wilms' tumour, and supports the view that adult Wilms' tumour is more sensitive to such agents.


The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.


Our observations suggest a new model for metabolic encephalopathy studies and provide insight into the mechanisms of pigmentary retinopathy.


These cases suggest that marked acid reduction may predispose to esophageal candidial infection.


Effects of highly overdosed indomethacin in a preterm infant with symptomatic patent ductus arteriosus.


This study is based on the neuropathological and systemic findings among 225 liver, 101 heart, 40 lung, 28 heart-lung, 74 kidney and 32 bone marrow transplants.


Epstein-Barr virus-associated lymphoproliferative disorder in a patient with rheumatoid arthritis on methotrexate and rofecoxib: idiosyncratic reaction or pharmacogenetics?


During the first day of infusion, she began having severe shortness of breath.


An apparent breed susceptibility of Collie dogs was observed.


One patient received a total of four injections in the right eye and three injections in the left eye.


Transient anuria following administration of angiotensin I-converting enzyme inhibitor (SQ 14225) in a patient with renal artery stenosis of the solitary kidney successfully treated with renal autotransplantation.


CONCLUSION: It is important to elucidate the precise nature of new onset hearing loss in patients receiving iron chelation therapy, in order to avoid unnecessary cessation of much needed medication, on the assumption of ototoxicity.


Prospective, controlled trials are warranted to further define the optimal dose, toxicity and potential role of cidofovir in renal transplant recipients with BK virus nephropathy.


Rifampin can be associated with severe adverse effects such as hepatitis, acute renal failure, hemolytic anemia, and thrombocytopenia.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever.


This finding suggests that fluvoxamine can precipitate Schneiderian first-rank symptoms in some susceptible patients.


We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.


The patient presented with severe bladder pain, fever, and eosinophilia several hours after instillation.


Liver disease induced by perhexiline maleate.


An 80-year-old man with bilateral basal ganglia bleeding was unable to swallow safely and required tube feeding.


IOP control had been poor prior to the laser-treatment, and did not appear to be more following treatment.


Patients were reviewed at intervals of 2-4 weeks for 12 months.


Two months later repeat colonoscopy with biopsies showed no evidence of collagenous colitis.


The serum concentration of AZ was elevated to a maximum of 76.5 mg/ml.


Those side effects that occurred, predominantly iron deficiencies, hypertension, and hyperkalemia, were controlled by appropriate clinical management.


Trichosporonosis appears to be an emerging fungal infection among immunocompromised individuals (including both hematological and solid organ transplant recipients).


The pregnancy was terminated, and she delivered at 27 weeks' gestation.


The use of outpatient dobutamine infusions by a small, portable infusion pump in 3 patients with intractable congestive heart failure (CHF) is described.


Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.


After the addition of citalopram, a desmethylclomipramine plasma level increase and an 8-hydroacy-desmethylclomipramine plasma level decrease were observed.


Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.


INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.


OBSERVATIONS: We observed aggravation and spreading of a psoriatic plaque when treated topically with the toll-like receptor (TLR) 7 agonist imiquimod.


We present a case of disseminated histoplasmosis, complicated by retroperitoneal bleeding and leading to death, in a patient who was receiving systemic immunosuppressive therapy for rheumatoid arthritis and who was enrolled in a gene-therapy trial.


Use of midodrine (Gutron) to treat permanent hypotension in a chronic hemodialysis patient.


A 36-year-old man being treated with cisplatinum, vinblastine, and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia, encephalopathy, and a partial nondominant parietal lobe syndrome.


Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.


This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.


Careful clinical and hematological monitoring should be performed, especially for the first 3 months, in patients beginning treatment with Pentasa.


Leflunomide was stopped.


Comedication included N-acetylcysteine, atenolol, and isradipine.


Sirolimus has been widely used in renal transplantation, and its use in heart transplantation is increasing.


In two patients clozapine was reinstated after risperidone was discontinued; serum triglyceride levels increased.


We report a rare case of patient with dermatomyositis (DM) who developed spontaneous pneumomediastinum (PnM) and subcutaneous emphysema.


Before ICU admission, the patient had suffered from painful mucositis causing severe dysphagia and bleeding, which was thought to be the result of chemotherapy.


An 86-year-old African-American man presented with tonic-clonic seizures.


Endocrinologically speaking, three of them had "Hashitoxicosis", while the other had silent lymphocytic thyroiditis.


A 58-year old man was admitted to the hospital because of melena.


The observed alterations of the thyroid gland were caused by a long lasting Wolff-Chaikoff effect with a delayed adaptation to high iodide concentrations.


CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.


We report of a 42-year-old man, in whom pyomyositis developed while he was receiving the standard chemotherapy for T-cell non-Hodgkin's lymphoma (NHL).


When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.


This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel.


These results emphasise the difficulty of stimulating this mesencephalic region.


A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.


Clevudine myopathy in patients with chronic hepatitis B.


The patient has since returned to his routines of daily living and has reported no fatigue or other lingering adverse symptoms.


Although thiazide-induced photosensitivity is a well-documented phenomenon, there have been no histologically proven cases of a lichenoid eruption in light exposed areas in the recent literature.


Accidental overdose of multiple chemotherapeutic agents.


SUMMARY OF BACKGROUND DATA: Meningiomas are known to enlarge in response to female sex hormones.


Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.


The patient was treated with mesalamine and prednisolone, and a repeat colonoscopy revealed an improvement in his bowel disease.


We concluded that the colonic ulcer and the sigmoidovesical fistula had been caused by the administration of calcium polystyrene sulfonate and sorbitol.


This report suggests that, like immunoblastic sarcoma, lymphomatoid granulomatosis may develop under conditions of diminished immunologic surveillance, whether iatrogenic or naturally occurring.


The patient's symptoms resolved with oral vancomycin and his stool C. difficile toxin became negative.


These findings are consistent with the assumption that long-term corticosteroid administration potentially induces not only myopathy but also motor neuron involvement as in mitochondrial diseases.


In contrast, other common agents for the most part trigger cutaneous inflammation.


Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia.


Since the drug's approval, the manufacturer has received infrequent although serious reports of diarrhea and ischemic colitis in patients taking the drug.


It may be advisable to consider thromboprophylaxis in head and neck surgery in patients with clinically suspected pulmonary thromboembolism, if no contraindication exists.


Although there have been reports of this occurrence, there have been no reports of this overlap syndrome treated with immunomodulators.


While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.


CONCLUSION: Despite adequate measures to prevent infection, orbital cellulitis may complicate strabismus surgery.


Her platelet count increased to 130,000/ mm3.


Emergency management of upper airway angio-oedema after routine dental extraction in a patient with C1 esterase deficiency.


The patient was normotensive and afebrile.


Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.


Case failure analysis and a review of the literature.


Stable renal function followed the initiation of high-dose subcutaneous heparin therapy.


These defects were apparently reversible upon the discontinuation of tiagabine.


Restless legs syndrome and periodic limb movements during sleep probably associated with olanzapine.


Haemophagocytic lymphohistiocytosis (HLH) is an uncommon disease with a high fatality rate.


We studied the effect of ramipril on urinary protein excretion and arterial pressure in a 27-year-old patient with GSD Ia and heavy proteinuria (2-3 g /24 h).


In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.


Results of coronary investigations were negative.


Trichosporon mucoides fungemia in a liver transplant recipient: case report and review.


Although the association between KS and renal transplant has been well documented, there are a few KS cases in the literature associated with membranoproliferative glomerulonephritis or other glomerular diseases.


High-grade atrioventricular block during dipyridamole stress testing.


We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.


Their medical treatment regimens included the use of topical 1% clotrimazole.


Flecainide-associated pneumonitis with acute respiratory failure in a patient with the LEOPARD syndrome.


He was of unusual personality and had bizarre ideas on self-regulation of his diabetes, resulting in wide variations of insulin dosage.


This report describes a method of applying photodynamic therapy in the biliary tract by using accessories available in the United States.


Blood glucose levels, which were normal before treatment, dropped to 2.3 mmol/l within a few hours and were corrected by i.v. glucose infusion.


The central retinal vein occlusions resolved when the immunoglobulins were withheld and serum hyperviscosity decreased.


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


At this writing, few cases of nondurally based intradural meningioma have been reported.


Remission of clinical signs in early Duchenne muscular dystrophy on intermittent low-dosage prednisolone therapy.


PURPOSE: To describe a case of progressive outer retinal necrosis in a human immunodeficiency virus-negative immunosuppressed patient undergoing treatment for graft-versus-host disease after bone marrow transplantation.


Case vignettes are described.


Post-transplant, the patient received single donor leucocyte transfusions, which resulted in a dramatic increase in neutrophil count.


RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine.


CASE REPORTS: Case 1: A 53-year-old male alcoholic received cyanamide treatment for 4.5 months and completely abstained without cyanamide treatment for 6 years.


This parasite lives in soil contaminated with human feces.


Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.


Persistent corneal erosion secondary to tarsal adrenochrome deposit.


This form of ARF is characteristically anuric and follows a distinctive clinical course.


Although a potential interaction between propafenone and SSRIs has been noted, a MEDLINE search revealed no published reports of an interaction between propafenone and citalopram.


Serum PRL values rose normally after TRH administration, and evaluation of other pituitary hormones was normal.


Motor neuron involvement in a patient with long-term corticosteroid administration.


Case study: complications associated with anticoagulant therapy.


Caudal epidural blood patch for treating intractable vomiting in a child after placement of a permanent intrathecal catheter.


We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).


Heparin cessation is a vital first step in treatment; however, alternative anticoagulant therapy is essential.


Ciliary beat frequency (CBF) was measured using video microscopy.


This report suggests that patients taking bone metabolism regulators may not be able to respond appropriately to hypocalcemic stressors.


Chest radiographs and computed tomographic findings showed a mass in the right upper lobe and effusion.


Vardenafil is a new oral phosphodiesterase inhibitor used for erectile dysfunction.


In this review, we summarize the available evidence regarding the safety and efficacy of using the anticonvulsants carbamazepine and valproic acid during pregnancy.


Although evidence of congestive heart failure was evident, dialysis was avoided without significant sequelae.


This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.


CASE SUMMARY: We report the case of an 81-year-old white man (weight, 82 kg; height, 173 cm; photodamaged type II skin) affected with cirrhosis of the liver, chronic idiopathic myelofibrosis, and a 3-year history of longitudinal melanonychia and periungual hyperpigmentation.


Risperidone-induced obsessive-compulsive symptoms in two children.


RESULTS: Glycopyrrolate successfully treated intraoperative penile erection.


Diarrhoea, T-CD4+ lymphopenia and bilateral patchy pulmonary infiltrates developed in a male 60 yrs of age, who was treated with oxaliplatinum and 5-fluorouracil for unresectable rectum carcinoma.


We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).


METHODS: This study is a case report description.


The 1-, 2- and 3-year survival rates were 100, 28.9 and 9.6% in all, and 100, 33.3 and 0% in six patients with portal vein tumor thrombosis (PVTT).


Rifampin-induced hypothyroidism without underlying thyroid disease.


Retinoic acid may increase the risk of bone marrow transplant nephropathy.


Acute interstitial nephritis due to pantoprazole.


The aim of this article is to report weight loss in patients with schizophrenia after switching from olanzapine standard oral tablet (SOT) to olanzapine orally disintegrating tablets (ODT).


To demonstrate that the 2-yr clinical follow-up of our patient strongly suggests that long-term therapy with posaconazole (POS) is safe and beneficial in treatment and prevention of relapses of, otherwise fatal, central nervous system mucormycosis.


Both neonates were normal at birth and have shown subsequent normal development.


Severe rhabdomyolysis following massive ingestion of oolong tea: caffeine intoxication with coexisting hyponatremia.


Nabumetone-associated interstitial nephritis.


Despite supportive care, the dog's neurologic status deteriorated progressively until parenteral treatment with clindamycin was instituted.


To our knowledge, drug-induced fever has not been reported with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker.


On admission the patient showed signs of incipient cardiogenic shock.


Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.


The authors note that catatonia is a clinical syndrome associated with multiple medical conditions as well as psychiatric disorders.


The temporal sequence of the respiratory insufficiency and the histopathology, when compared to the previous examples in the literature, suggest that cyclophosphamide was aetiologically responsible for the lung disease.


After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h.


At this time (1994), esophagogram and esophagogastroscopy evidenced varicosities in the lower esophageal section (stage F1).


The prognosis of AILD is generally poor, with a median survival of less than 20 months.


METHODS: On the basis of two cases, the clinical picture is described in relation to the available literature.


Thymic hyperplasia following successful chemotherapy.


Chemical and traumatic alopecia from thioglycolate in a black woman: a case report with unusual clinical and histologic findings.


We present findings from three patients who experienced a psoriasiform eruption apparently due to the antiepileptic agents sodium valproate and carbamazepine.


Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.


We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.


The patient experienced a relapse in his bipolar disorder,and olanzapine was restarted at 20 to 40 mg per day.


Ten of these 12 patients also developed severe pulmonary edema.


Using repeated computed tomographic and magnetic resonance imaging scans, we examined 8 patients with acute lymphocytic leukemia during remission induction therapy between 1988 and 1989.


Retinopathy of prematurity (ROP) is a multifactorial disease affecting the developing retinal vasculature and remains an important cause of blindness in very preterm infants.


Myoclonus has been reported as a side effect of antidepressants, and the serotonin hypothesis has been advanced to include this syndrome.


Clozapine is the first choice antipsychotic medication for treatment-refractory schizophrenia; however, there are some disadvantages in using clozapine.


In two patients, no myocardial infarction occurred, as shown by a normal postoperative left ventricular angiogram.


In CAPD patients with candida peritonitis, fluconazole seems to offer several advantages over other antifungal drugs.


METHODS: Four consecutive patients underwent high-risk penetrating keratoplasty (4 grafts) with a prior diagnosis of corneal scar secondary to herpetic keratitis, keratoconus, acanthamoeba keratitis, and Fuchs endothelial dystrophy, respectively.


The hemodynamic changes, underlying mechanisms and therapeutic strategies are discussed.


Such atypical cases may support either a spectrum concept of NMS or the theory that NMS secondary to atypical antipsychotics differs from that caused by conventional neuroleptics.


Azathioprine can cause severe myelosuppression.


In a few cases, toxicity related to concomitant medications could also be involved.


Complete remission of nephrotic syndrome (NS) occurred in two patients, partial remission in one patient, while treatment was inefficacious in one (data not available for one patient).


METHODS: Four solid organ transplant patients with severe hypoxemic P. jiroveci pneumonia were treated with the combination of trimethoprim-sulfametoxazole and caspofungin.


By day 8 the patient was comatose, with minimal signs of brain activity and little hope for recovery; on day 12 he died.


Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.


RESULTS: After a single PDT treatment, visual acuity increased from 20/50 to 20/20.


Malignant lymphoma involving the penis following malignant pleural mesothelioma.


Acute adrenal insufficiency after large-dose glucocorticoids for spinal cord injury.


The cervical sympathetic chain is composed of superior, middle, intermediate, and inferior cervical ganglia.


CT showed deep RIF extending from the vocal cords to the carina, with laryngotracheal compression but without cancer recurrence.


The first FAB infusion (320 mg) was started 11 h after drug ingestion.


An epidural blood patch was performed and enoxaparin was prescribed for 6 months.


BACKGROUND: Vicks VapoRub (VVR) [Proctor and Gamble; Cincinnati, OH] is often used to relieve symptoms of chest congestion.


This is probably the first case report of motile Enterococcus infection of the central nervous system.


Uses and safety of acyclovir in pregnancy.


There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.


We report of a 32-year-old man who showed dystonic symptoms within few days after liver transplantation (LT).


The second patient developed both autoimmune thyroid disease and a refractory pre-patellar bursitis after 50 months of IFN-beta therapy.


Four years after achieving CR, she developed complicated life-threatening pulmonary infections with methicillin-resistant Staphylococcus epidermidis and Aspergillus niger during outpatient care.


A patient with Parkinson's disease, initially treated with bromocriptine and subsequently with cabergoline, developed progressive pleuropulmonary abnormalities during the latter therapy.


Drug-induced lymphocyte transformation test before desensitization was negative with a stimulation index of 130%.


There are few published reports that discuss oral burns in children.


A paradoxical ocular effect of brimonidine.


Small cell carcinoma of the lung is the tumor most commonly associated with ectopic ACTH production and hypercortisolism.


A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman.


OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.


Pseudoephedrine-induced hemorrhage associated with a cerebral vascular malformation.


WE is attributable to thiamine (vitamin B1) deficiency.


This is of concern, particularly in a context of increasing use of immunosuppressive drugs in UC.


A diagnosis of acute transverse myelitis was made and the patient was treated with IV methylprednisolone and IV immunoglobulin.


A thorough examination at the hospital gave no evidence of underlying diseases that could explain the reaction.


A 7 year-old Turkish boy presented with a euthyroid goiter, which was noted during evaluation of familial Mediterranean fever.


Familiarity with these hair practices will aid in the accurate diagnosis, prevention, and proper management of this problem.


Up to now, however, its healing effect on bronchiectasis has never been demonstrated.


HCV RNA was positive in serum, and chronic HCV infection was detected by liver biopsy.


Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.


Confidence and conditional confidence levels for the preferred decision are derived from gaussian theory, and the mutual information index that identifies probabilistically important tree variables is provided.


Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.


During IFN therapy, he had normal aminotransferase levels and no detectable HCV RNA, a condition that persists to the present.


Ileal ulcers and cytomegalovirus infection in a case of Churg-Strauss syndrome.


In the other 2 patients, hyperintense lesions in the periventricular white matter were transient and no neurologic sequelae ensued.


It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.


The patient's isolate was susceptible in vitro.


Acute INH neurotoxicity was not suspected on the first admission; however, when readmitted 4 weeks later with another seizure, the diagnosis of acute INH neurotoxicity was made.


CONCLUSION: With anti-tuberculous treatment, renal functions and visual disturbances were improved in a patient with miliary tuberculosis.


His dibucaine number was 21, and the Michaelis constant was 5.5 times that of normal sera.


Hemorrhagic cystitis is a significant toxic effect of cyclophosphamide therapy.


We report two cases of tenofovir (TDF)-associated nephrotoxicity in perinatally HIV-infected adolescents.


There were no complications of persistent bacteremia despite placement of the stent-graft device at the site of primary infection, reinfection, delayed rupture, paraplegia, distal emboli, or surgical conversion.


According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.


She did not experience any reactions.


Treatment with heparin may be of help in situations where there is a delay in elimination of the underlying cause.


We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.


We describe nine patients with cardioembolic stroke who experienced clinical deterioration associated with computed tomography-documented hemorrhagic transformation.


Aggressive suppletion with intravenous potassium and bicarbonate combined with potassium-sparing diuretics and ACE inhibitors resulted in complete restoration of the serum potassium and resolution of the neurological symptoms.


There was resolution of the inflammation; however, bullous keratopathy was subsequently noted in the cornea.


After the most recent surgery, he suffered transient cauda equina symptoms.


BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.


Statistical significant risk factors for the developing of visual disturbances were found to be the ingested quantity of methanol, the latent period, acidosis and serum methanol concentration on admission.


We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.


A review of the literature showed no previous description of this pattern in benzodiazepine coma.


We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.


Upon review of the literature, this appears to be the first documented case of drug-induced photosensitisation in the cat.


Metformin is described as a glucose-lowering agent for treatment of type 2 diabetes mellitus and as antiobesity drug, though results achieved with this last indication are not conclusive.


Although this G-CSF-driven leucocytosis was alarming it did not appear to have adversely affected the patient's prognosis.


We discuss a patient with a history of a positive tuberculin skin test, who presented with severe, recalcitrant palmoplantar pustular psoriasis with psoriatic arthritis whose symptoms did not resolve with monotherapy of etanercept (Enbrel) or efalizumab (Raptiva) alone, but did respond to a combination of both biologics.


Each was analyzed to determine a mechanism of the hypersensitivity reaction and subsequent management outcomes.


The lesions were lichenoid in appearance and this was confirmed histologically.


Apparently, the subacromial injection penetrated the anterior half of the supraspinatus tendon, causing a transient effect and signal change.


BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.


However, a method to differentiate the neuromuscular block induced by magnesium from that induced by curariform nondepolarizing muscle relaxant in the clinical setting has never been reported.


We recommend that bisphosphonates be used with caution in patients with myeloma and renal impairment, that vitamin D deficiency be corrected prior to treatment (to reduce the risk of hypocalcaemia) and that serum calcium and renal function be monitored during treatment.


Bone marrow aspiration revealed cell maturation arrest.


Here, we present an angiosarcoma of the neck occurring after curative chemoradiation.


Circadian rhythm of white blood cells during clozapine treatment.


We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.


CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.


The patient was not obese.


It is usually a consequence of direct extension from an underlying bony lesion, in the setting of multiple myeloma.


Neurologic disturbances (ataxia and prostration) were significant clinical findings.


We report three cases of ophthalmic problems that were treated with a short course of oral corticosteroids and which resulted in the development of hyperosmolar hyperglycemic nonketotic coma.


An unusual patient with post-transfusion purpura is described who had a rapidly rising platelet count with high dose steroid treatment in the presence of an increasing anti-PlA1 antibody titre.


Three patients with major depression superimposed on chronic dysthymia were treated with phenelzine.


Interventional pain management is an evolving field, with a primary focus on the safety of the patient.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


The authors report the first case of bucillamine-induced giant mammary hyperplasia.


The respiratory rate improved within 5 to 10 minutes of methylene blue administration and continued over a period of 2 hours.


The fourth patient showed RLS symptoms that were initially caused by a 20-mg daily olanzapine dosage and were later mitigated when olanzapine was reduced and ropinirole was administered.


We experienced a case of chronic renal failure in a patient suffering from acute hemorrhagic gastritis associated with AZ intoxication.


The patient recovered clinically and, in less than 4 weeks, her serum bilirubin and aminotransferases returned to normal levels.


A report on two cases.


This case highlights the importance of muscle biopsy in HIV infected patients whose myopathy persists despite withdrawal of antiretroviral therapy and the need for thorough investigation of non-specific symptoms in HIV infected patients who are receiving antiretroviral therapy.


The patient attained a final height of 160.8 cm, which was appropriate for her target height.


PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.


A 50-year-old woman with migraine was admitted to hospital shortly after having abruptly developed hemiparesis.


At 29 months of age, she developed diarrhea with bulky stools and weight loss.


We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.


Acute pulmonary reactions to nitrofurantoin are an uncommon side effect of therapy and can cause minor or life-threatening pulmonary dysfunction.


Effect of a GnRH analogue (leuprolide) on benign prostatic hypertrophy.


Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine: case report and review.


One male patient with bilateral DME was treated by intravitreal pegaptanib in his right eye every 6 weeks for 6 months (five injections) and followed for 42 months.


This case describes a 52-year-old white woman who developed a spontaneous nasal septal perforation after given the antiangiogenic drug, bevacizumab, for metastatic ovarian cancer treatment.


The relative etiologic significance of the stress of status asthmaticus, administration of theophylline, or corticosteroids is open to question.


Close follow-up during the first month of life is warranted for infants exposed to diazepam prenatally.


Long lasting respiratory depression induced by morphine-6-glucuronide?


Because nephrotic syndrome may be induced by IFN therapy, the IFN was stopped.


Twenty-seven patients with inoperable or recurrent primary malignant brain tumors after previous resection and/or radiotherapy, were treated with corticosteroids and a combination chemotherapy consisting of VM 26 and CCNU.


In HIV-infected patients with metabolic disorders, as in the general population, there is evidence of hypertension requiring pharmacological treatment.


Creatinine 8 days earlier was 0.9 mg/dL (79.6 micromol/L).


A 51-year-old male with a huge chondrosarcoma received subarachnoid dorsal root blocks with 10% phenol in glycerine to treat severe pain along the left leg.


As anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) were positive, she was diagnosed with ANCA-associated vasculitis and treated with corticosteroids.


The authors report the case of an 87 year old woman who first developed this disorder at age 82 and was successfully treated with valproate and L-thyroxine.


St Jude's Total XIII protocol was started.


We report a case of sustained hypotension after administration of parenteral verapamil.


It is suggested that the hypermagnesemia directly suppressed PTH secretion, resulting in symptomatic hypocalcemia.


These symptoms resolved over a period of five days.


Termination of pregnancy resulted in dramatic improvement in airflow.


I suggest that prior to giving amphotericin B to patients with resistant kala-azar their electrolyte imbalance should be corrected.


A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.


Erythropoietin is beneficial in mitomycin-induced hemolytic-uremic syndrome.


We report a 60-year old, male patient of Pulmonary Tuberculosis who was started on antituberculous treatment (ATT) with rifampicin (R), isoniazid (H), ethambutol (E) and pyrazinamide (Z) together for initial two months and R, H & E thereon.


A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.


Phenylpropanolamine (PPA) recently has been publicly implicated as a cause of stroke and other neurologic events.


He became unconscious and inhaled noxious substances from the smoke.


Rush oral desensitization with Viokase solution was attempted, starting with 5 mg, and the dose was doubled every 20 minutes, aiming to reach a cumulative dose of 700 mg.


Five patients underwent botulinum toxin injection into the insertion of the levator and tensor veli palatini muscles.


SMS treatment arrested progression of tumor growth only in patients in whom there was a reduction in gastrin and gastric acid secretion.


Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.


This resulted in loss of seizure control and a decrease in his serum carbamazepine concentration from 12.4 to 6.7 micrograms/mL.


The persistence of free steroid secretion with decreased formation of DS suggests that the o,p'-DDD may have altered sulfatase activity before causing tumor necrosis and total decrease in steroidogenesis.


His akathisia symptoms worsened thereafter.


Ten weeks after infliximab infusion, neutrophil count and GBA and anti-NA assay returned spontaneously within normal range and we observed the same progress after every successive infliximab infusion we performed.


The third patient, who was elderly, survived because of early detection and initiation of therapy.


Laser-Doppler flowmetry on the toe of the left foot disclosed an increased blood flow and an abnormal fluctuation of the cutaneous capillary blood flow, i.e. a high amplitude rhythmic (HAR) wave with 2.5 to 3 cycles.min-1.


The harlequin color change and association with prostaglandin E1.


In-111 platelets accumulated markedly over the abdominal aortic graft with a shortened platelet survival time and reflected changes in hematologic studies, which showed low platelet counts and a high concentration of fibrinogen degradation products in the plasma.


A dermatologist diagnosed this as Sweet's syndrome caused by G-CSF; consequently G-CSF administration was stopped.


Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.


Issues relevant to child and adolescent psychopharmacology arising from this case are discussed.


He was followed exclusively by the psychiatry service for more than a year.


Cardiac hypersensitivity and myopericarditis have been reported during long-term treatment with mesalazine.


Pathogenesis of acute renal failure: new aspects.


Abnormalities resolve with drug withdrawal.


Depression was not improved and she complained of fatigue, lack of energy and drowsiness.


Fat embolism in infancy after intravenous fat infusions.


The dosage, side-effects and precautions are discussed.


Reactions to Aquaphor: is bisabolol the culprit?


All patients who developed diarrhea after undergoing the cancer chemotherapy were examined to determine whether or not they were complicated by C difficile colitis.


This paper reports a case of peritonitis by Nocardia asteroides during continuous ambulatory peritoneal dialysis in a man who had systemic lupus erythematous and chronic renal failure.


A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide (750 mg/day).


Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.


To the authors' knowledge, there is a paucity of published accounts of management of radiation-induced optic neuropathy (RION) by optic nerve sheath fenestration (ONSF) in the conventional medical literature.


We present a case of steroid- and cyclophosphamide-resistant nephrotic syndrome complicated by disseminated strongyloidiasis which responded to anthelmintic agents.


We report a case of AILD in an 80-year-old male who presented with a generalized pruritic maculopapular eruption and fever following doxycycline administration.


He was treated with topical steroids with healing of the lesions, leaving only post-inflammatory hyperpigmentation.


It was hypothesized that valproic acid may interfere with glucuronidation of lamotrigine, leading to increased serum lamotrigine levels, or perhaps alter the drug's metabolism, resulting in accumulation of a toxic intermediate metabolite.


Cutaneous biopsy showed hyphae and round inclusions stained with PAS and Gomori-Grocott within a polymorphous granuloma.


In addition, testosterone supplementation is frequently recommended for adult men with reduced libido or impotence and decreased serum levels of testosterone.


We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.


CONCLUSION: This rare therapy-related second malignancy developed after curative larynx-preserving treatment.


Her mother ingested therapeutic doses of nimesulide, a non-steroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy.


Case 4: A 61-year-old male alcoholic who remained completely abstinent while taking cyanamide for 3 years showed slight elevation of serum transaminases.


However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.


Ocular involvement in benign botulism B.


Fatal agranulocytosis: the use of olanzapine in a patient with schizophrenia and myelodysplasia.


While excisional surgery remains the benchmark management for nonmelanoma skin cancer, topical imiquimod and C&C are important options for treating SBCCs.


Localized panniculitis and subsequent lipoatrophy with subcutaneous glatiramer acetate (Copaxone) injection for the treatment of multiple sclerosis.


Neuroleptic malignant syndrome and neuroleptic-induced catatonia: differential diagnosis and treatment.


With the use of optical coherence tomography (OCT), two patients with IFN-associated retinopathy who had developed macular edema and reduced visual acuity during the clinical course of IFN therapy were observed.


CASE REPORT: The safety of combination therapy with nab-paclitaxel, an albumin-bound paclitaxel, and sunitinib, a tyrosine kinase receptor inhibitor, was evaluated retrospectively in three patients with advanced, previously treated metastatic esophageal cancer, non-small cell lung cancer (NSCLC), and small cell lung cancer (SCLC), respectively.


Further studies are warranted into the pathogenesis of this unique phenomenon.


Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.


We discuss the implications for current diagnosis and management of HIV-associated pulmonary diseases.


However, special attention must be paid to patients developing early active HCMV infection under prophylaxis.


The authors report a case of acute renal failure caused by fungal bezoar in the renal pelvis.


Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.


PURPOSE: To review the current literature on suspected green tea-related hepatic reactions and to describe two new cases reported within the framework of the Italian surveillance system of natural health products.


Before therapy 14 of the patients were unemployed; after therapy only two did not work.


On postoperative day 30, the patient developed primary CMV disease that responded to ganciclovir.


Biomicroscopy was performed.


We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.


Neutropenic enterocolitis: is there a right timing for surgery? Assessment of a clinical case.


SSRIs and fentanyl are commonly co-administered, especially in the setting of chronic or malignant pain, as underlying depression may contribute to the pathogenesis of pain.


Few of these historical therapies have been rigorously investigated.


In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis.


Serum tryptase rose to three times the normal value.


Average time interval between surgery and thrombus formation is 26 months (max 204, min 1 month).


We therefore intended to verify whether a standard (tailored) chemotherapy, without the use of prophylactic blood product transfusions, could be applied during treatment of acute leukaemia under such circumstances.


Improvement of anemia by recombinant erythropoietin in patients with myelodysplastic syndromes and aplastic anemia.


One patient developed late peripheral embolization most probably due to late mobilisation of a thrombotic fragment.


It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.


Risperidone versus clozapine in the treatment of psychosis in six patients with Parkinson's disease and other akinetic-rigid syndromes.


Multifocal electroretinography (mfERG) disclosed markedly low-amplitude responses at fixation and in the regions corresponding to the visual field defects.


DISCUSSION: Itraconazole pulse therapy for onychomycosis appears to be at least as effective as and safer than a continuous treatment regimen, particularly from the perspective of potential liver damage.


Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure.


Tacalcitol is a synthetic vitamin D3 analogue developed for topical treatment of inflammatory skin diseases such as psoriasis.


Prompt recognition of a chlorambucil drug reaction is essential in patients receiving chemotherapy.


The pharmacological management of rapid cycling bipolar disorder in the elderly is also reviewed.


Our cases include a 35-year-old woman with (sub)fulminant hepatitis, a 67-year-old woman with macronodular cirrhosis, and a 68-year-old man with severe chronic active hepatitis and cirrhosis, with positivity of anti-smooth muscle antibodies.


DESIGN: The medical records of three patients with CSC who were found to use inhaled adrenergic agents or corticosteroids or both were identified prospectively.


The median age was 73 years (range 41-81).


The eye developed a necrotizing scleritis secondary to O. sulphureo-ochraceum.


Successful treatment of massive pulmonary embolism with prolonged catheter-directed thrombolysis.


The clinical effect and safety of Lp-TAE alone and combined with radiofrequency (RF) capacitive hyperthermia (HT) were evaluated in 20 patients with hepatocellular carcinoma (HCC) associated with cirrhosis of the liver.


The effect of regional perfusion treatment on recurrent melanoma of the extremities.


In both cases, hypoglycemia due to oral antidiabetics was not seen.


We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.


Herpes simplex esophagitis in a renal transplant patient treated with cyclosporine A: a case report.


OBJECTIVE: Neuroleptic Malignant Syndrome (NMS) is a rare but potentially lethal form of drug-induced hyperthermia.


We also review other patients with paradoxical seizure exacerbation by benzodiazepines.


PURPOSE: To describe 2 cases of sterile corneal ulcers that persisted after several weeks of therapy with topical moxifloxacin 0.5% but that resolved when antibiotic therapy was changed.


Two patients are described who developed testicular swelling and pain during treatment with desipramine.


Slight elevation of serum transaminases and hepatic hyperechogenicity were observed.


Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan.


The patient's stool sample was found to be positive for the C. difficile toxin.


The resurgence of HBV DNA preceded the elevation of liver enzymes for 20 weeks.


Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.


This was associated with polyuria but no significant hyponatraemia.


Further testing at 28 months revealed a serum T4 value of 7.8 micrograms/dl and a serum T3 value of 141 ng/dl.


The occurrence of torsades de pointe is often associated with the use of drugs.


Here we describe a patient with Crohn's disease who developed a severe infliximab infusion reaction (IIR), complicated 1 day later by severe swelling of the forearm and hand ipsilateral to the site of infliximab infusion.


Even after its discontinuation, the patient experienced the rash on a long-term basis, with periodic exacerbations.


Recovery was observed with supportive therapy after 2 and 1 weeks, respectively.


During the epidemic period, 43% of the S typhimurium isolates submitted to the Arizona Department of Health Services were resistant to chloramphenicol, and 80% of these possessed the same plasmid resistance.


These include injections of botulinum toxins to correct the shape of the nasal tip and the use of various fillers to correct contour and profile defects.


He developed fever, nausea, diarrhea, and malaise and stopped taking on the third day after commencing Pentasa.


The salmon calcitonin is used in some osteomuscular diseases.


Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate.


Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.


She had also been submitted to radiotherapy for a subcutaneous plasmacytoma, detected some months before, at the same site of the cutaneous lesions.


No virus particles were detected by electron microscope.


We report here the case of a patient with peritoneal metastases of GIST involving the pelvis treated by imatinib.


Interstitial lung disease has been reported in association with numerous alkylating agents and other chemotherapeutic drugs.


We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy.


Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.


When patients with PNH are infected by PVB19, they may show severe neutropenia and mild thrombocytopenia in addition to severe reticulocytopenia.


Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.


The urinary concentrations of the main tubular enzymes (gamma-glutamyltranspeptidase, N-acetyl-glucosaminidase, alpha-glucosidase) proved very high and successively decreased slowly.


The results of a histopathological examination of the renal biopsy specimen were unremarkable.


A case of successful treatment of antibiotic-associated pseudomembranous colitis with oral metronidazole is reported.


Their diagnoses were: chemotaxis defect, cellular immunodeficiency, combined immunodeficiency and chronic granulomatous disease (CGD).


Epstein-Barr virus-associated lymphoproliferative disorder (EBV-LPD) is an uncommon but potentially fatal complication of allogeneic stem cell transplantation.


In this patient, the recurrence of the disease, the presence of filamentous strands on electron microscopy during both bouts of hepatitis and the efficacy of ribavirin on post-transplantation hepatitis suggest that the disease was caused by an original virus.


Other related complications include decreased bone healing and inhibition of orthodontic tooth movement.


Reversal of neuroleptic-induced stupor by procyclidin.


Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.


When a subsequent allergic reaction occurs, the ethylenediamine component of aminophylline is usually not suspected as the etiologic agent.


The combination of maintenance ECT and lithium may be safe and effective in selected cases of refractory depression.


The authors also determined that their case of myositis developing in the rectus abdominus muscle of a patient with pancreatic adenocarcinoma was the manifestation of radiation recall, thereby bringing the number of patients who developed radiation recall to gemcitabine and were discussed in the current study to 13.


Each dog developed arterial hypertension, with systolic, diastolic, and mean arterial pressures ranging from 170 to 205, 90 to 112, and 123 to 148 mm of Hg, respectively.


The patient was also found to have Hashimoto's thyroiditis.


Acute dystonia during pegylated interferon alpha therapy in a case with chronic hepatitis B infection.


Careful review of the literature suggests that corticosteroid-induced liver damage may be more frequent than commonly believed.


Nineteen immunocompromised patients with extensive skin lesions caused by Pseudomonas aeruginosa with or without P. aeruginosa bacteremia were analysed.


We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).


Transvaginal intratubal insemination, ectopic pregnancy and treatment by single-dose parenteral methotrexate.


Therefore, thrombin should be used only as a last resort, short of craniotomy, to control intractable arterial hemorrhage during stereotactic brain biopsy.


Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.


The authors report a case of laryngeal necrosis after combination therapy for a patient with cervical lymph node metastases of nasopharyngeal carcinoma and review the literature on late laryngeal necrosis.


Ticlopidine-induced marrow aplasia treated with cyclosporine.


After the start of insulin therapy, there was a remission period for about 3 years but insulin-dependency recurred thereafter.


A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.


MAIN OUTCOME MEASURES: Time periods from onset to diagnosis and from diagnosis to clinical resolution, and the final visual acuity.


Treatment was initiated with intravenous tobramycin 560 mg daily and piperacillin/tazobactam 4.5 g infused every 6 hours.


The investigators studied a patient with a nortriptyline HCI level of 1,205 ng/mL who had four generalized grand mal seizures, each lasting between 60 and 90 seconds that were immediately followed by hypotension requiring norepinephrine support.


The patients had experienced loss of employment and the carers described a reduction in the patients' social interactions.


Olanzapine was detected and quantitated by basic liquid-liquid extraction followed by dual-column gas chromatographic analysis with nitrogen phosphorus detection.


CASE REPORT: Soon after initiation of amiodarone HCl (200 mg/day), a 76-year-old man came to us with symptoms of visual "shining," glare, color vision anomalies, and gradually decreased vision.


We report a patient with post-transplant lymphoma who was treated by renal allograft nephrectomy, discontinuation of immuno-suppressive therapy, and initiation of acyclovir administration.


This case supports the view that in gold-induced pneumonitis a prolonged treatment with corticosteroids may be necessary, as lung function continued to improve.


Myelodysplasia terminating in acute myeloid leukemia in a hairy cell leukemia patient treated with 2-deoxycoformycin.


A previous study of patients with "quinine-associated TTP/HUS" found that ADAMTS13 activities were not abnormal in 12/12 patients.


The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.


Reiter's syndrome, immunodepression and strongyloidiasis.


In addition, the in vivo immunological study also revealed an intercellular fluorescence, similar to that seen in pemphigus.


CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.


Tardive and chronically recurrent oculogyric crises.


Physicians should be aware of the presence of corticosteroids in over-the-counter products, that are not mentioned on the instruction leaflet.


Hydroxyurea associated with concomitant occurrence of diffuse longitudinal melanonychia and multiple squamous cell carcinomas in an elderly subject.


Three patients, in whom tumour overkill by cytotoxic treatment, including high dose methotrexate with folinic acid rescue, resulted in the 'phosphate shower syndrome' (hyper-uricaemia, hyperkalaemia and hyperphosphataemia with hypocalcaemia and tetany, with metabolic acidosis and acute renal impairment) are described.


We report the first case of Leuconostoc infection in a solid organ transplant recipient.


A leukemoid reaction is a complex and poorly understood response by the bone marrow to a variety of stresses; although any peripheral blood cell line may be involved, it is rarely a purely monocytic event.


In addition, they should continue to reserve its use for moderate-to-severe Pneumocystis jiroveci pneumonia for which trimethoprim-sulfamethoxazole is ineffective or contraindicated.


For those patients with a history of NMS, or even of isolated serum CK elevation during antipsychotic therapy, follow-up should be stricter.


One initially received diethylstilbene followed by estradiol, 80 mg monthly, and finally estramustin, 140 mg twice daily.


The HIPA assay provides a simple and sensitive laboratory method for the choice of an innocuous heparin or heparinoid for continued parenteral anticoagulation.


The patient's medical history was significant for heart transplantation due to ischemic heart failure.


Two patients who received granulocyte colony stimulating factor (G-CSF) before or during radiotherapy are reviewed.


The ocular effects of intracarotid bromodeoxyuridine and radiation therapy in the treatment of malignant glioma.


The source of fever was never identified, although infection with cytomegalovirus was considered the most likely cause.


METHODS: Endoscopic retrograde cholangiography was performed to define the proximal and distal extent of intraductal tumor.


Treatment was started with heparin and vasodilators.


Seven of 10 patients experienced serious adverse events, which led to withdrawal of linezolid in all seven.


AILD is characterized by generalized lymphadenopathy, hepatosplenomegaly, immunological abnormalities, polyclonal hypergammaglobulinemia and anemia.


Chest radiography showed central bilateral opacities and pleural effusion as confirmed by the high-resolution computed tomography that demonstrated diffuse ground-glass and interlobular septal thickening as well.


However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.


CASE DESCRIPTION: We have observed severe infusion reactions accompanied by a loss of consciousness in two patients.


Hypo-oestrogenic and anabolic/androgenic side-effects of danazol are well known by the gynaecologist and some of them are present in > 50% of patients being treated for endometriosis.


The entity is likely more common than the paucity of reports in the world literature suggests, and all physicians should recognize its graphic appearance to avoid unnecessary exposure to agents in an effort to treat it.


Brain abscess following insertion of skull traction.


After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.


We have found that higher doses, up to 1,500 micrograms per day, which have generally been free of side effects, are sometimes required to normalize growth hormone secretion.


Renal tubular acidosis was complicated by probable nephrogenic diabetes insipidus and acute renal failure.


This case should alert clinical oncologists to pay attention to mental symptoms after prescribing a corticosteroid.


We report the case of an 87-year-old white woman with myasthenia gravis who presented with nausea, shortness of breath, azotemia, and hyperkalemia shortly after completing a course of intravenous immunoglobulin (IVIG).


RESULTS: Careful blood cell monitoring showed a pronounced diurnal variation of WBC (2.9-4.2x10(9)/l in the morning and 3.6-7.1x10(9)/l in the afternoon) and granulocytes (0.8-1.4x10(9)/l and 2.9-5.5x10(9)/l, respectively).


Treatment with diazepam led to resolution of symptoms within 6 hours, and there was no recurrence at 6 weeks' follow-up.


PSL was commonly effective in inducing remission in very elderly patients (7 of 9 patients; 78%).


RESULTS:Haze, uncorrected visual acuity (UCVA), and BCVA improved in all patients.


CONCLUSIONS: Interventions aimed at reducing pain associated with CIPS may include the initiation of calcium-channel blocker therapy and conversion to an alternative calcineurin inhibitor.


Adalimumab, a fully human, immunoglobulin G1 monoclonal antibody that binds to tumor necrosis factor, has been approved for the treatment of moderate-to-severe psoriasis, in the U.S., Europe and elsewhere.


We describe 2 patients with severe erosive rheumatoid arthritis and rheumatoid vasculitis, respectively, in whom infliximab therapy was associated with peripheral neuropathy due to necrotizing vasculitis in one patient and to progression of preexisting mononeuritis multiplex in the other.


Bilateral percutaneous nephrostomy catheters were placed in the renal pelvises, and local irrigation with amphotericin B was performed for 3 weeks.


This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.


As an apparent result of their immune modulating activity, there has been an observed association between the use of these agents and the development of a wide range of infections, most notably Mycobacterium tuberculosis.


Extended-release tolterodine 4 mg/day was then prescribed to manage overactive bladder.


Five and one-half years after the diagnosis of myeloma, while in remission on cyclophosphamide therapy, the patient experienced severe abdominal right lower quadrant pain due to a large cecal lymphoma.


METHOD: Case report.


CT-scan disclosed right ethmoid sinusitis that spread to the orbit after surgery.


Drug-induced mammary hyperplasias have been reported as rare complications of D-penicillamine and Neothetazone.


Following this occurrence of respiratory depression nebulised morphine was discontinued and no further events occurred.


Therefore long-term suppressive antibiotic treatment was not indicated.


Previous successful treatment with one ACE inhibitor does not rule out the vasculitis caused by the drug from the same group.


OBJECTIVE: We sought to describe the clinical course after copperhead bites.


The hearing impairment and tinnitus were gradually reduced after PTU withdrawal and corticosteroid and azathioprine treatment.


One of the subjects who was using extemporaneous topical minoxidil had hypertension and arteriosclerotic disease and the other died of a myocardial infarction.


As a result of the advances in acute rheumatology and improved emergency services, an increasing number of patients survive episodes of severe disease and complications of immunosuppressive therapy.


We believe this is the first report of myocardial infarction due to coronary spasm, demonstrated by angiography associated with L-thyroxine therapy.


To avoid menstruation by the female patient just in the critical stage, we modified her menstruation cycle by testosterone.


He is being followed with repeated imaging studies for a small abdominal aneurysm.


Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.


The safety profile of this treatment in critically ill patients has not been fully evaluated.


We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide.


We suggest that in patients treated with olanzapine, CK concentrations should be checked on initiation of therapy, within the first 48 hours, and weekly thereafter for at least one month.


OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.


Thus cabergoline may cause similar pleuropulmonary abnormalities to bromocriptine.


A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.


Since tamoxifen therapy can induce endometrial disorders, surveillance schemes of women taking tamoxifen have been recommended.


Laboratory evaluations disclosed normal electrolytes, hemograms and non-toxic serum MTX levels at the onset of the symptoms.


Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.


RESULTS: Our patient developed Crohn's disease while on Copaxone treatment as a consequence of long-term immunosuppression.


Perforation of the bladder seems to be iatrogenic (primary) or drug-induced (secondary).


A patient with a primary malignant brain tumor on chronic corticosteroids presented with a clinical picture of cord compression and was diagnosed with SEDL.


A severe lidocaine intoxication by cutaneous absorption is described.


We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).


This was characterized by inflammatory arthritis and an urticarial and papulosquamous rash and was accompanied by high titers of antinuclear, double-stranded DNA, glomerular-binding, and histone antibodies and by reduced levels of the C4 component of complement.


A 55-year-old Caucasian man was admitted to hospital with triple vessel disease.


A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements.


In patients with swallowing dysfunction and pneumonia, a history of mineral oil use should be obtained and a diagnosis of ELP should be considered in the differential diagnoses if mineral oil use has occurred.


Physicians and patients must use more caution with teratogenic prescription drugs.


The interaction between phenytoin, thyroid function, and thyroid replacement therapy is discussed.


Generalised pustular psoriasis induced by cyclosporin a withdrawal responding to the tumour necrosis factor alpha inhibitor etanercept.


Salmon calcitonin in the treatment of post herpetic neuralgia.


Mental status, vital signs, and all laboratory parameters including thyroid function tests, normalized.


Rarely, pleural effusion and/or pulmonary hemorrhage may occur.


Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.


Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.


She was suffering from an unspecified interstitial lung disease, papillary thyroid carcinoma which had been treated, hypoparathyroidism after thyroidectomy for which she was receiving dihydrotachysterol and calcium, and atrial fibrillation and congestive heart failure as a result of mitral stenosis.


Ten of them were given the agent while the femoral arteries were compressed, to prevent loss of the agent into the external iliac arteries.


METHODS: Ten consecutive patients with culture proven MDR-TB were treated with the novel antibiotic drug linezolid in combination regimens for 6-40 (median 17) weeks and followed up 11-50 (median 24) months after end of treatment.


Two other patients were treated with clotrimazole as well as propamidine isethionate and neomycin sulfate-polymyxin B sulfate-gramicidin from the outset, and had an excellent response to medical therapy.


The three index patients underwent: (1) left stellate ganglion block; (2) beta-blocker challenge; and (3) electrocardiographic stress testing.


In one case the recognition of anterior vitreous face contact to the cornea was delayed by the severity of the corneal edema.


We report four cases of severe corneal ulceration in methamphetamine abusers.


The patient's beta-blocker therapy may have masked additional signs of NMS.


OBJECTIVES: This article focuses on those patients where particular agents should not be used: i.e. 'when not to use what'.


Amphotericin B overdose in pediatric patients with associated cardiac arrest.


Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.


Antibiotic-associated neutropenia.


The most common complications of the use of central venous catheters include infection and venous thrombosis whereas pulmonary septic emboli are rare.


CONCLUSION: Pancreatic enzyme intolerance, although rare, would be a major problem in the management of patients with CF.


Successful rescue of severe recurrent hepatitis C with interferon and ribavirin in a liver transplant patient.


Her clinical symptoms improved with discontinuation of pranlukast and administration of systemic corticosteroid.


A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis.


Skin rash and splinter hemorrhages from ganciclovir.


Oligohydramnios and pulmonary hypoplasia: a case in which involvement of an angiotensin II receptor antagonist was suspected.


The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.


Prompt diagnosis of WE is important because it is potentially fatal and readily treatable with thiamine supplementation.


Despite normal coagulation parameters, the cerebral hematoma enlarged over 36 hours, as documented by sequential computed tomographic scans, to produce significant mass effect, which prompted surgical evacuation.


An 8-year-old girl with pauciarticular disease, antinuclear antibody, and uncontrollable iridocyclitis underwent 16 plasma exchanges with 5% albumin solution as replacement; despite removal of antinuclear antibody, her eye disease and arthritis were not helped.


It has a significant adverse effect profile, with 30-45% of patients reporting cardiac adverse effects and 15-20% experiencing noncardiac events.


We describe a 5-year-old girl with Ph(+) CML who received a cord blood transplant in a second accelerated phase after a very early lymphoid blast crisis.


We present an exceptional case in which full-thickness eyelid necrosis ensued following intralesional injection of corticosteroids in a capillary hemangioma.


We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.


Muscle involvement is also common, although it usually remains asymptomatic.


CONCLUSION: We have introduced a case of anaphylaxis by calcitonin that suggest an IgE mediated hypersensitivity reaction.


Seventeen months after recovery, the patient was rechallenged with ART without recurrence of lactic acidosis.


Antibodies to native or ultraviolet-irradiated DNA were not demonstrated.


Laboratory investigations for uveitis were negative and the patient required systemic and intensive topical steroids with cycloplegics to control the inflammation.


Mycophenolate mofetil-induced neutropenia in liver transplantation.


Perilymphatic atrophy can be a complication of intralesional corticosteroid injections given for the treatment of conditions such as psoriasis, alopecia areata, and keloids, and intraarticular corticosteroid injections given in diseases such as rheumatoid arthritis.


This is believed to be the third case of bacteraemia outside of Asia due to C. indologenes and the first in a diabetic child not otherwise immunocompromised.


IL-2 was part of the regimen.


Thus, our report suggests that SKT could be a first-line agent for the conservative treatment of TOS.


He subsequently had a resolution of all signs and symptoms, suggesting that these alarming events were a toxic but reversible side effect of the chemotherapy.


A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.


OBJECTIVE: To present a previously unreported cause of neurologic compromise after cervical spine surgery.


A clinical study was initiated to determine if this mode of treatment would be effective against certain primary and metastatic cutaneous malignancies.


School-based methylphenidate placebo protocols: methodological and practical issues.


This is the second report of acute lung injury and diffuse alveolar damage caused by mefloquine.


6-Thioguanine (6-TG) is a thiopurine analogue that is closely related to 6-mercaptopurine (6-MP) and azathioprine (AZA).


CONCLUSIONS: The normal host response to a cosmetic filler is a weak granulomatous reaction.


Two patients with severe dialysis osteomalacia, whose fractures and deformities had become progressively worse over 3 years, were treated with desferrioxamine (DFO).


As is known, tamoxifen therapy is related to endometrial proliferation, hyperplasia, polyp formation, invasive carcinoma and uterine sarcoma.


Contraindications for mannitol in aphakic glaucoma.


Drug withdrawal resulted in a slow and progressive reduction in bilirubin levels and liver enzymes.


Agitated dysphoria after late-onset loss of response to antidepressants: a case report.


2 months later symptoms had resolved with a control CT of the thorax showing complete regression of the pulmonary changes.


With the increased use of indwelling central venous catheters, increasing numbers of cases of Rhodotorula fungemia have been observed in patients with neoplasia and neutropenia.


After several months, neither patient required antidiabetic treatment.


A case may be made for the discontinuation of the usage of chloral hydrate.


It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.


Eventually she showed apneic spells and hyperglycemia.


Our purpose is to alert surgeons and therapists to a rare but potentially devastating complication and to provide our experience in treating it.


Although useful in the management of chronic alcoholism, disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae, which now include catatonia.


As NBD-Cl has not been reported as an allergen before, the characteristics of this chemical and its use as an analytical reagent are briefly surveyed.


Immunoprecipitation analysis revealed a band with the molecular weight of the Band 3 anion channel only in the presence of the patient's serum and oxaliplatin.


Five patients were treated with topical neomycin-polymyxin B-gramicidin (Neosporin) and propamidine isethionate (Brolene) drops.


Protein in vitamin K absence (PIVKA) is the prothrombin precursor found in plasma when carboxylation to prothrombin is impaired.


Mitral valve endocarditis resulting from coagulase-negative Staphylococcus after stent implantation in a saphenous vein graft.


This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile.


We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.


During the following years, the patient was retested regularly.


These enzymes may be associated with toxic reactions of differing frequency and severity.


Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.


CASE REPORT: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer.


The role of antiemetics is invaluable in allowing cancer patients to complete, otherwise possibly intolerable, chemotherapy.


The catheter had been in place for 28 months for administration of a 27 month course of intravenous cefotaxime for an unsubstantiated diagnosis of chronic Lyme disease.


Patient 2 underwent two attempted operative anastamotic revisions with thrombectomies and local thrombolysis prior to CDT.


Subsequently, five episodes of Wenckebach (Mobitz type 1) heart block with a ventricular rate of 28 beats/minute were observed on continuous cardiac telemetry.


Electron microscopy revealed selective loss of myosin filaments in many fibers.


She subsequently developed similar symptoms after multiple rechallenges with various loop diuretics including furosemide, bumetanide, and torsemide.


It is of value in treating temper states in epilepsy and has the advantage of not causing extrapyramidal symptoms and side-effects are slight after the first week.


The authors calculated that the blood lactate concentration could rise by 50% without requiring net lactic acid accumulation when the severe acidemia was corrected by alkali therapy.


Before FAB therapy was started, the total serum DGTX concentration was 535 nmol/l.


In some patients, this pH shift may be quite transient and temporary; whereas, in some patients with other maladies, the acidosis may be much more serious.


Clinical consequences are discussed and disturbances of the blood brain barrier system as a speculative cause are hypothesized taking previous studies, animal studies and an additional reported clinical case into account.


In the course of modifying her anticonvulsant regimen, the authors examined the 6beta-hydroxycortisol/cortisol ratio (6beta-OHF/F) in her urine, which can be the index of hepatic CYP3A4 activity, with electrospray ionization/mass spectrometry/mass spectrometry (ESI/MS/MS).


Hemostasis was difficult to achieve, as the divided or disrupted amyloid-laden cortical vessels failed to vasoconstrict, their contractile elements replaced by amyloid beta protein.


The clinical and histologic presentation of this side effect and possible biochemical mechanisms of pathogenesis are discussed.


A 16-year-old poorly compliant, steroid-dependent subject with asthma received two courses of high-dose intravenous methylprednisolone during a 3-week period, followed by a tapering schedule of oral prednisone.


Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype.


We present a case report where switching from clozapine to quetiapine maintained the improvement in clinical status, after remittance of eosinophilia.


Development of tics in a thirteen-year-old male following atomoxetine use.


A 37-year-old female patient was diagnosed with ulcerative colitis 8 months ago and medical treatment with oral azathioprine, low-dose corticosteroids and 5-ASA was started.


Severe apnea in an infant exposed to lamotrigine in breast milk.


Despite vigorous therapy for the hyperthermia, he rapidly developed significant hypoxia requiring mechanical ventilation.


These results suggest that the slowed clearance of cerivastatin in this patient might have been compounded by cytochrome P450, 2C8 dysfunction.


Nitrofurantoin is commonly used to treat urinary tract infections during pregnancy.


After 14 months of follow-up, the patient is well and free of disease.


The postoperative course was uneventful and topical steroids were combined with neomycin and propamidine.


Medicolegal problems in the management of cardiac arrhythmias in children.


Hematological toxicity was moderate even at the 100 mg/m2 dose level.


A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.


Coagulase-negative staphylococci were detected in cerebrospinal fluid (CSF), and the infection persisted even with intrathecal administration of gentamycin, and intravenous administration of vancomycin and arbekacin.


Parameters of potassium, sodium, calcium, and phosphate metabolism as well as specific renal functions have been studied in the basal state and during administration of graded doses of phosphate (500-6000 mg).


PURPOSE: Visually significant, pigmented cellular membranes may form on intraocular lenses after implantation.


Interstitial pneumopathy and low-dosage amiodarone.


Bisphosphonates in oral or intravenous forms are used to treat various diseases such as certain cancers, bone- and calcium-related disorders, osteoporosis, and osteopenia.


The dog underwent multiple operations involving internal fixation of the fractured scapula with wire and a plate, followed by extensive chemotherapy with antibiotics and prednisolone.


On visual field testing, a progressive evolution to a total and absolute central scotoma in the RE (central 10 degrees ) and an annular scotoma in the LE became apparent.


Both patients recovered immediately without any signs of adverse effects and the two shunt systems have now been working properly for more than 36 and 21 months, respectively.


A case of transient bullous dermolysis of the newborn associated with Wilms' tumor is reported.


Asthmatic patients receive multiple drugs as part of their treatment program.


Multiple stones and tumor cells infiltration were demonstrated in both kidney.


We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.


Development of neuroleptic malignant syndrome (NMS) following discontinuation of high-dose and high-potency neuroleptic agents is described.


Barbiturates offer a mechanism of action that is different from that of benzodiazepines.


Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression.


Hydroxyurea (HU) and sodium phenylbutyrate (SPB) have been shown to increase fetal hemoglobin (Hb F) levels in patients with thalassemia intermedia.


OBJECTIVE: To report on the possible development of serotonin syndrome in a patient receiving clomipramine after clozapine was withdrawn from the treatment regimen.


We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.


Untreated tumors displayed continued growth.


We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma.


We described a patient who developed heart failure and pericarditis after bone marrow transplantation for a hematologic malignancy.


METHODS: Single case report of failure of Baclofen pump investigated by radioisotope injection.


Exposure to the individual compounds was determined by calculating the AUC.


Transient decreases in hematocrit, complement components, and immunoglobulin concentrations occurred.


Endoscopic injection of sclerosing agents is a strategy for control of esophageal varix bleeding.


Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.


The progressive regression was remarkable.


He underwent removal of the allograft and implantation of another liver.


Sleep improvement in an insomniac patient with global pituitary insufficiency after change from triple to quadruple cortisol replacement therapy.


His immune system at this time was almost completely depleted.


Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.


Bortezomib is the first anticancer proteasome inhibitor introduced into clinical practice.


Recurrent ischemic stroke involving an initially unaffected arterial territory during the course of thrombolysis has been reported but remains exceptionally rare.


Genotyping prior to medication may be useful in evaluating patients with a high risk of severe systemic reaction to SASP.


In this report, we suppose the possibility to develop a foetal malformations after a long-term wash out from isotretinoin therapy.