The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


The development of internal tissue inflammation is reportedly correlated with a shorter interval from the time of completion of radiation therapy to the initiation of chemotherapy.


When camptocormia was diagnosed, olanzapine was withdrawn and levodopa was introduced.


Although PTLD is uncommon in the general community, the incidence has continued to increase as more patients undergo transplants and clinical presentations of PTLD should be familiar to the otolaryngologist.


Rheumatoid arthritis (RA) is an autoimmune disease associated with altered immunoregulation and resulting in a deforming polyarthritis.


CONCLUSIONS: This case report showed that the clinical appearance of Hashimoto's disease after IFN-alpha therapy for chronic C hepatitis in our patient was associated with a specific genetic predisposition (DR5) for this pathology.


It may be confused with intracranial tumors and requires long-term combined antibiotic therapy after drainage.


Rifampicin and ethambutol were stopped.


Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma.


A 16-year-old girl with pulmonary stenosis who underwent reconstruction of the right ventricle outflow tract experienced severe bronchospasm following CPB.


We should take dental treatment into account one of predisposing causes of tricuspid endocarditis.


We report a case of demyelinating disease occurring in a patient treated for psoriasis.


Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline.


The effects on different biophysiological parameters and subjective impressions were studied in a patient with breast cancer who was not previously given any therapy before receiving Ukrain.


Because of the clinical state of acute pain associated with lack of or inadequate care to relieve the symptoms, some patients use self-medication.


In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.


This finding suggests a dopaminergic mechanism specifically in changing the frequency of cycling between depression and mania.


A young diamond dealer developed visual impairment attributed to bilateral posterior subcapsular cataracts following only four courses of intermittent Decadron used as part of a five-drug antiemetic regimen for cisplatin-associated nausea.


The patient improved within 10 d with reduced ocular swelling and pain, and 6 months after therapy stop, she is in good health and cultures are sterile.


We administered five cycles of IV Cidofovir with a 1-week interval between the first and second treatment, followed by 2-week intervals thereafter.


Thus, in many cases, the possible benefit of thrombolysis during CPR seems to outweigh the potential risks.


The purpose of this article is to present the first case-series of posterior reversible encephalopathy syndrome (PRES) associated with L-asparaginase treatment.


These cases demonstrate that therapy for disseminated MAC infection is sometimes difficult even with HAART and macrolides-containing regimens.


Although there were few cases in which psychotropic medication was effective against coprophagia, we encountered a patient with schizophrenia in whom coprophagia rapidly disappeared after treatment with perospirone, a novel atypical antipsychotic drug of the serotonin-dopamine antagonist (SDA) type.


Here, we report the first case of successful redo aortic valve replacement using a Prima Plus stentless valve (Edwards Lifesciences, Irvine, CA, USA) followed by a 6-week course of ciprofloxacin and gentamicin for early PVE caused by MBL-producing P. aeruginosa.


Bone marrow aspiration day +4 still showed hypo-normocellular marrow, with remaining 6% plasma cells.


A 72-year-old woman suffered obtundation, intractable pulmonary edema, acidemia, and irreversible renal insufficiency despite vigorous hemodialysis.


Comparing his coronary angiograms with those obtained before surgery indicated a severely spastic left coronary artery.


RESULTS: Thirteen patients had died; 1 of these died of liver failure.


However, it is controversial whether progressive hepatic lesions develop in complete abstainers as a result of long-term cyanamide treatment.


Her course continued to be complicated until consistent follow-up with a nutritionist was established.


The clinicoradiologic features in this patient were consistent with posterior leukoencephalopathy, which is a rare complication of chemotherapy.


Lack of experience with patient reporting in real life was one of the main drawbacks in this debate.


Gastric tumor, endometrial carcinoma and cervical adenocarcinoma in situ were detected after treatment with tamoxifen for breast cancer.


The results thus far are very encouraging and the study is being continued.


CONCLUSIONS: Carboplatin desensitization can be successfully performed on an outpatient basis with close observation and cardiorespiratory monitoring.


Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.


Four patients were treated with acyclovir, but three were given suboptimal doses.


Thus, troglitazone should be prescribed with caution and should not be used as a first-line agent in the treatment of type II DM when potentially less toxic alternatives are available.


The leukoencephalopathy, documented clinically and by CT and EEG, cleared after 2350 mg of leucovorin (citrovorum factor, folinic acid) was given in addition to the 135 mg given as part of the therapy.


Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.


OBJECTIVES: The improvement of pre-existing inflammatory bowel disease after orthotopic liver transplant might be anticipated.


OBJECTIVE: To report a case of calcineurin-induced pain syndrome (CIPS) in a child undergoing his second hematopoietic stem cell transplant (HSCT).


Von Willebrand's disease has been established as the most common hereditary hemorrhagic disease.


To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.


We hypothesize that during interferon therapy, melanocytes may produce more melanin pigment in the presence of alpha-melanocyte stimulating hormone and sufficient amounts of tyrosine, leading to melanin deposits and clinical hyperpigmentation.


Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration.


We describe a patient with the antiphospholipid syndrome who had skin necrosis develop from low-molecular weight heparin therapy at sites distant from injection sites.


Impairment of consciousness developed with a remarkable temporal delay of 24 to 48 hours after occurrence of peak serum concentrations and resolved with a comparable delay after reaching the therapeutic range (anticlockwise hysteresis).


We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar).


Recent studies show that patients with other injury patterns do not appear to have significant differences post trauma, although the data about such outcomes is sparse.


Minimal change nephrotic syndrome after allogenic hematopoietic stem cell transplantation.


We calculated the changes in alpha(1)-adrenoceptor occupancy by endogenous norepinephrine during treatment with the usual doses of milnacipran, fluvoxamine and imipramine by using pharmacokinetic and pharmacodynamic parameters obtained from the literature.


The neuropathologic findings in these cases, although similar, varied in severity and distribution.


High-dose tamoxifen in treatment of brain tumors: interaction with antiepileptic drugs.


It is suggested that the patient had sulfasalazine-induced lupus, which manifested with serositis and pulmonary parenchymal involvement in the absence of joint symptoms.


OBJECTIVE: To report a case of significant hepatic and renal failure with the use of argatroban in a patient with heparin-induced thrombocytopenia (HIT) requiring continuous veno-veno hemodialysis (CVVHD).


Patient ages ranged from 19 to 36 years at the time of diagnosis of their Crohn's disease, and all were white.


The children were symptom-free at follow-up, which ranged from 5 months to 3 years.


Possible mechanisms for damage to the urothelium by ketamine are suggested.


Crumley).


Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.


The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.


Care should be taken in prescribing antipsychotic drugs to patients who are prone to cardiovascular side effects, and alternatives to antipsychotics with prominent anticholinergic profile, in particular, should be sought.


Three patients were treated with aminocaproic acid for medically uncontrolled hyphemas that developed after cataract extractions.


Although some reports suggest that treatment with recombinant erythropoietin may affect A1C values in patients undergoing hemodialysis, we know of no evidence to support this interaction in patients with chronic renal insufficiency who are not undergoing hemodialysis.


The remainder of the procedure was uneventful.


Priapism as a complication of heparin therapy.


Phenytoin and carbamazepine were necessary to control the seizures.


Pyogenic portal vein thrombosis as a reservoir of persistent septicemia after cyanoacrylate injection for bleeding gastric varices.


Severe granulomatous inflammatory response induced by injection of polyacrylamide gel into the facial tissue.


The diagnosis was based on the rapid onset of renal failure, presence of eosinophilia, skin rash, and characteristic renal biopsy finding, following the administration of ampicillin.


Therapy with IFN-beta has rarely been associated with the development of autoimmune disorders.


Although combinations of belladonna, ergotamine, and phenobarbital have been used for medical treatment of menopausal symptoms since the 1960s, this is the first known case report of its association with anticonvulsant hypersensitivity syndrome.


After 1 week of nefazodone therapy the patient experienced headache, confusion, and "gray areas" in her vision, without abnormal ophthalmologic findings.


We reviewed all cases of RS reported to the Michigan Department of Public Health during 1982 and 1983.


However, increasing the indometacin dose to 4 mg/kg/day improved their growth significantly, without changing their symptoms or biochemistry.


For nearly half a century, FMF was thought to cluster primarily in non-Ashkenazi Jews, Arabs, Armenians, and Turks, although the screening of the 8 known mutations in an American cohort has identified substantial numbers of people from the Ashkenazi Jewish and Italian populations in the United States who also have this disease.


Familial Mediterranean Fever (FMF) is an inherited disease, closely following the pattern of autosomal recessive inheritance.


PURPOSE: To report a case with concentric retinal pigment epithelium (RPE) atrophy after a single photodynamic therapy (PDT).


We present the case of a 75-year-old man with ankylosing spondylitis who developed surgically induced necrotizing scleritis (SINS) more than 3 years after uneventful extracapsular cataract extraction and posterior chamber intraocular lens implantation.


The day after clozapine was stopped, while he was still receiving clomipramine 150 mg/d, he began behaving oddly, started sweating profusely, shivering, and became tremulous, agitated, and confused.


Most antidepressants and also antipsychotics are metabolized by the polymorphic debrisoquine/sparteine hydroxylase, i.e., cytochrome P450 (CYP)2D6.


Through November 30, 2004, the FDA received 6 reports of DIC associated with "acute hemolysis" (or similar terms), 5 of which involved fatalities.


We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.


Loiasis, caused by the filarial parasite Loa loa, is endemic in West and Central Africa.


Cardioembolic stroke, early anticoagulation, and brain hemorrhage.


The authors report 2 cases of renal damage associated with lithium carbonate treatment.


A 22 year old female was admitted to hospital two hours after ingesting 4 g of dapsone.


The authors describe a case of combined lithium and haloperidol toxicity characterized by hyperpyrexia, severe rigidity, mutism, and development of irreversible tardive dyskinesia.


Using insulin's ability to promote fat and protein synthesis is a simple and effective way of treating atrophied scars.


Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.


Thiazide-induced hyponatremia.


Two patients treated for chronic myeloid leukemia with high doses of CCNU (1100 mg/m2 and 1240 mg/m2, respectively) developed a fatal pulmonary fibrosis.


RESULTS: A clinical diagnosis of fixed drug eruption owing to use of the PDE5 inhibitor tadalafil (Cialis) was made.


In view of the potential hazards of tissue plasminogen activator, close pediatric ICU monitoring is indicated with the use of high-dose tissue plasminogen activator infusions.


Histopathologic examination and direct immunofluorescence test were consistent with IgA bullous dermatosis.


Within 6 weeks, endophthalmitis resolved in three consecutive patients with positive aqueous cultures.


We present a case of interstitial pneumonitis and diffuse alveolar hemorrhage, which represents the second such case reported in the literature.


The first patient was supported by the use of a paracorporeal air-driven left ventricular assist device of the NCVC type, and had a moderate degree of renal and hepatic dysfunction at the time of transplantation.


When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.


All patients had inadequate ACT measurements, despite conventional heparin dosage and ongoing clopidogrel treatment.


Acute INH toxicity should be suspected in children presenting with seizures with or without fever.


Prenatal cytomegalovirus (CMV) infection associated with severe brain damage was detected in an infant whose mother had been treated with prednisolone and azathioprine for systemic lupus erythematosus (SLE).


A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.


About 7% of Caucasians are poor metabolizers (PM), and such patients might develop adverse drug reactions when treated with recommended doses of, for example, tricyclic antidepressants.


BACKGROUND: Uterine malignant mixed mesodermal tumor is a rare variant of uterine cancer.


Twenty-five (86%) patients had initial visual acuity of less than 20/60.


Analysis of a phenotyped human liver bank revealed that the antibodies recognised a 52.5 kDa microsomal protein which exhibited marked heterogeneity in its expression and appeared to be regulated co-ordinately with human CYP2C8 and 3A3/4.


We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.


The infant developed repeated tongue thrust, abnormal hand posturing, and tremor of all extremities.


Meperidine-associated central nervous system (CNS) excitatory toxicities are believed to be caused by accumulation of the active metabolite normeperidine.


We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily.


RESULTS: Intradermal tests to intravenous cyclosporine formulation (1 mg/mL) were positive in the patient and negative in two controls.


Treatment of iron overload in adults with continuous parenteral desferrioxamine.


Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.


A 5-month-old infant became lethargic and poorly responsive after receiving 1 drop of brimonidine in each eye.


We then review case reports, expert opinion, and manufacturer recommendations regarding hepatitis B viral infection, TNF-alpha, and TNF-alpha inhibitors.


A total of 311 patients (35.5%) had at least one small intestinal resection.


Case report and literature review.


CASE SUMMARY: An 84-year-old woman presented to the emergency department with a bilateral cervical hematoma and symptoms of upper-airway obstruction that had been increasing for 72 hours, with dyspnea and difficulty speaking developing in the previous 24 hours.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


Pathological examination of both resected femoral heads showed no intravascular thrombosis.


A case report of treatment with intra-arterial urokinase and review.


He was administered insulin immediately, however, his fasting plasma glucose level remained unstable despite the insulin treatment.


Once regarded as fatal not many series of patients with ITO have been reported with the long follow up as in the present case.


CT scan of the abdomen disclosed a huge abscess in the right lobe of the liver.


A case of immunosuppressive measles (rubeola) encephalitis in a 12-year-old boy in remission from acute lymphoblastic leukemia is described.


We suggest that dapsone is an effective second-line agent in the treatment of rheumatoid arthritis.


Final evaluation was made 12 weeks after the competed dose consolidation.


The administration of "sweet spirits of nitre" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.


Treatment of dialysis osteomalacia with desferrioxamine.


Flucloxacillin is a commonly prescribed semisynthetic penicillinase-resistant penicillin primarily used for the treatment of cutaneous staphylococcal infections.


Transtubular potassium gradient (TTKG) also decreased and an inverse correlation was found between TTKG and doses of phosphate (r = -0.37; p < 0.02; N = 38).


Eczematous eruptions may be produced through topical contact with mercury and by systemic absorption in mercury sensitive individuals.


Twenty patients with myelodysplastic syndromes (MDS) entered a randomized, placebo-controlled, double-blind trial designed to evaluate the efficacy and toxicity of high doses of recombinant human erythropoietin (rhEPO).


A 68-year-old woman with parkinsonism showed cortical myoclonus and seizures under antiparkinsonian medication.


The 3 others developed clinical pericardial tamponade before surgery.


Severe heroin-induced pulmonary edema occurred in three previously healthy young men.


Brain imaging was normal in all.


Mucosal pigmentation after oral lichen planus treatment with topical tacrolimus.


A chest radiograph demonstrated right pleural effusion.


She also had nephrotic range proteinuria.


METHODS: This is a retrospective, open-label study of 24 patients; 18 of whom were not responding to accepted medication for treatment of their TS and six of whom were receiving no medication.


A patient developed optic neuropathy while being treated with isoniazid and ethambutol.


Nine adult patients from three community teaching hospitals had bronchospasm unresponsive to standard therapy.


Although myelosuppression is mild, immunosuppression and superinfection are potential hazards of treatment with DCF.


Hemodialysis removal of acyclovir.


Based upon the observed fall of the filtration fraction, the rise in the relative clearance of 99Tc-dimercaptosuccinic acid and the increase in proteinuria, we suggest that in this case the tubules and/or interstitium are the main targets for cyclosporine A nephrotoxicity.


The current literature regarding the role of antibiotic prophylaxis in dermatological procedures is discussed along with the issues surrounding this patient.


SETTING: University hospital with a comprehensive in- and outpatient rehabilitation center.


Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection.


Blood chemistries revealed severely depleted sodium and potassium concentrations from a normal baseline within a 7-day period.


Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?


Results Radiographic responses to sirolimus were observed in all patients.


Triazolam-induced nocturnal bingeing with amnesia.


We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis.


It is suggested that charcoal haemoperfusion as well as cysteamine has a role in the management of severe overdosage with paracetamol.


It is noteworthy that the superior sagittal sinus thrombosis occurred during a haematological recovery period, with rapid responses to treatment with 6-mercaptopurine and high doses of adrenocorticosteroids.


The patient subsequently developed polyuria with a low urine osmolality, hypernatremia and, finally, acute renal failure.


The clinical polysomnographic (PSG) reports of 2,650 consecutive adults studied during 41 months were reviewed retrospectively to identify all patients treated with fluoxetine or tricyclic antidepressants.


Thirty-six patients with AL received, in a three-month period, 51 cycles of combined chemotherapy which included, in all of them, cytosine arabinoside (ARA-C); among them, along with myelosuppression, five experienced fever, infectious complications, gastrointestinal tract symptoms and severe myalgias.


The drugs concomitantly used were digoxin, isosorbide dinitrate, frusemide, urapidil and chlorthalidone in conjunction with oral potassium substitution.


Apart from some minor discomfort at the site of operation, no side effects were noted.


We labeled this new entity as a "plastobezoar".


Clozapine is an atypical antipsychotic drug, and there have been case reports that clozapine may be an effective treatment for tardive dystonia.


It gives an 'acetowhite' effect that may assist clinicians in identifying neoplastic areas.


Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins.


As reported by us, a new myeloid cell population with an oncofetal membrane marker, dimeric Lex (di-Lex; III3FucV3 FucnLc6), was found in the epiphyseal bone marrow adjacent to the involved joints of patients with severe rheumatoid arthritis (RA).


All patients had bleeding complications before and after VAD placement, necessitating multiple blood product transfusions.


ATT had to be stopped because of this adverse drug reaction.


We report successful treatment of a cryptococcal ventriculoatrial shunt infection with antifungal therapy without shunt removal.


A further case of anaphylactoid reaction to methylprednisolone is reported.


To our knowledge, these movements have not been reported previously as an adverse effect of quetiapine.


We examined a left-handed 25-year-old man engaged for 2 years at a vinyl chloride resin factory where he had been exposed to lead stearate, a stabilizer of resin.


A patient receiving vancomycin for a serious staphylococcal infection had a lupus-like syndrome characterized by a malar rash, pain and erythema of the cartilage of both ears, and tender erythematous and hemorrhagic lesions of the finger tips.


METHODS: A case is presented of a 45-year-old woman on prolonged gemcitabine treatment for ovarian cancer who developed HUS and recovered after drug discontinuation.


The patient was successfully treated by single-dose methotrexate (MTX) (77 mg or 50 mg/m2 given intramuscularly).


METHOD: Single case report.


Monozygotic male twins with DiGeorge's syndrome had facial dysmorphism, cardiovascular abnormalities, hypocalcemia, and immunodeficiency; however, they showed differences in several aspects of this developmental complex.


This approach could be discussed in a multidisciplinary setting in similar cases, especially due to the described negligible recurrence rate after successful initial thrombosis after treating femoral pseudoaneurysms, pseudoaneurysms of the pancreatic artery, or even endoleaks after stenting of aneurysms of the aorta.


We present the first case of a patient with priapism after oral intake of the phenothiazine prothipendylhydrochloride.


Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.


A 63-year-old man with decreased vision due to postsurgical chronic cystoid macular edema that was recalcitrant to topical nonsteroidal anti-inflammatory drops had resolution of cystoid macular edema after intravitreal triamcinolone injection.


Effectiveness of octreotide in a case of refractory sulfonylurea-induced hypoglycemia.


Inferior vena cava (IVC) filter thrombosis has been reported to occur in up to 30% of cases and is associated with significant morbidity.


Urgent surgical decompression was performed, showing an epidural hematoma.


We report a 28-year-old woman of normal intellect, who had three late-onset seizures with unusual ictal features and secondary generalization during prolonged and vigorous tooth brushing.


CONCLUSIONS: This case report suggests that there may be individuals that are very sensitive to increases in serotonin concentrations.


The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.


METHODS: A 44-year-old patient showed therapy-resistant cystoid macular edema for 2 years after repeated penetrating keratoplasty was performed as treatment of keratoconus.


He developed pronounced eosinophilia and a vasculitic skin rash, myalgias of the abdomen, upper trunk, and neck, and died of respiratory distress with no evidence of an infectious etiology.


A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO).


All three patients had been taking an atypical antipsychotic.


Linezolid is a recent addition to the antibiotic armamentarium against Gram-positive bacteria, including multiresistant staphylococci and enterococci.


Currently the use of zidovudine is one of the few specific measures available, and as a potentially teratogenic and fetotoxic agent, any decision for its use requires evaluation of the potential for fetal damage.


His counterpart would not order a CT but would check a baseline chest x-ray if there were any sign of pulmonary compromise (Dr.


In patients receiving erythropoietin, therapeutic decisions should be based on A1C and glucose levels, as well as patient symptoms suggestive of hypo- or hyperglycemia, to avoid therapy changes that could complicate disease management.


The diagnosis is confirmed by cytology, tissue studies, and viral cultures.


Sudan IV staining indicated many lipid droplets in follicular cells.


Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.


Further observations and reports will help clarify this adverse effect.


Pulmonary toxicity was dose limiting, with grade III toxicity occurring in all three patients treated at a dose of 100 mg/m2.


A nonfatal case of accidental prolonged overdosage of pyrimethamine (10 times the usual dose for 10 days) in a seven-week-old infant treated for congenital toxoplasmosis is presented.


For 9 years the patient remained totally asymptomatic.


In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.


A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).


Two 65-year-old white men with coronary heart disease, given niacin therapy for dyslipidemia for 5 months, developed intense dental and gingival pain that was associated with increases in dose and that was relieved with discontinuance of niacin treatment.


Two patients with adrenal carcinoma treated with 2,2-bis (2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane (o,p'-DDD) as adjuvant therapy were studied.


Treatment included isoprenaline for 28 hours.


Bicalutamide is a new, nonsteroidal antiandrogen with a favorable toxicity profile.


This extremely rare combination of haematomas may have been caused either by rupture of a small vessel in the arachnoid membrane or by rupture of the arachnoid membrane itself, secondary to a massive haemorrhage in the subarachnoid space.


In this report, we discuss the care of patients with aplastic anaemia in the peritransplant setting.


Histopathology examination of the excised flap demonstrated numerous Acanthamoeba cysts in tissue sections.


Although a continuous intravenous infusion of dobutamine was maintained, therapy with oral terbutaline 2.5 mg every 6 hours was initiated.


Paraplegia following prophylactic intrathecal cytosine arabinoside (Ara-C) is described in a patient with acute myelogenous leukemia in remission who received doses of 100 mg/m2/d for 5 consecutive days.


Bronchoalveolar lavage (BAL) cultures for bacteria, viruses, and fungi were negative, but testing for ova and parasites from BAL fluid revealed Strongyloides stercoralis larvae on day 16 post transplant.


DFO appears to be an effective treatment for severe dialysis osteomalacia.


Case report and review of the literature.


Patients with a haemoglobin level < 100 g/l were treated as out-patients for 12 weeks with daily doses ranging from 30 U/kg body weight (BW) up to 240 U/kg BW in non-responders.


Ocular and systemic complications such as eyelid necrosis, central retinal artery occlusion, and adrenal suppression have been reported rarely after corticosteroid injection.


The use of 1,25-dihydroxyvitamin D (1,25-OH2 D) plus calcium may be superior to the use of calcium alone in some forms of osteoporosis.


Our findings suggest that clozapine plus lamotrigine may be helpful in reducing alcohol consumption and craving among patients with schizophrenia and comorbid alcohol dependence.


Cardiopulmonary compromise after use of topical and submucosal alpha-agonists: possible added complication by the use of beta-blocker therapy.


A patient with a large hydatid cyst of the left lobe of the liver developed metabolic acidosis following rather liberal use of cetrimide-chlorhexidine solution as a scolicidal agent.


OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.


Extensive workup for other causes, including infections, was negative.


In case 1, a total daily dose of 25 mg sertraline, with nondetectable sertraline and desmethylsertraline blood levels, resulted in a doubling of the lamotrigine blood level with symptoms of toxicity.


Ischaemic complications of Glypressin in liver disease: a case series.


Strongyloides infection should be ruled out in patients with eosinophilia before immunosuppressants are initiated to prevent the complication of disseminated strongyloidiasis.


We review the medical literature and discuss the risks of using recombinant factor VIIa to control severe bleeding after cardiac surgery.


CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.


The incidence of this adverse effect in children and young adults who have cystic fibrosis is unknown.


Charcoal hemoperfusion led to rapid clearing of dapsone from the circulation.


The report is followed by a brief review of anticonvulsant hypersensitivity syndrome and DRESS.


However, as illustrated by these and other cases reported to date, the onset of troglitazone-induced liver injury is insidious and temporally variable.


We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis.


Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.


Spontaneous pulmonary hemorrhage following coronary thrombolysis.


The median age of patients was 61 years.


In six cases CT scans did not return to their original state after ACTH therapy.


Both patients had Campylobacter jejuni enteritis, and one case was complicated by bacteraemia.


A 42-year-old woman presented to our institution with a 2-week history of bone pain in the lower extremities.


The present patient was a 66-year-old Japanese woman who developed a cardiac arrhythmia and was given amiodarone as an anti-arrhythmic agent for approximately 3 months, until the day before her death.


Since November 1996, there has been a shortage of multivitamin infusion (MVI).


We describe two cases that illustrate the use of lithium in the treatment of veterans with PTSD who complained of serious problems with irritability or angry outbursts.


Follicular cell carcinoma of the thyroid in a child after bone marrow transplantation for acute lymphoblastic leukemia.


Serum concentration of cerivastatin at 6 h after taking the last dose (0.15 mg) was 8062.5 ng/L, which was almost 5.7 times higher than that of normal persons.


A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.


Initial clinical experience with centrifugal pumps coated with the Carmeda process.


METHODS: A 23-year-old contact lens wearer was treated for bilateral Acanthamoeba keratitis and underwent penetrating keratoplasty in the right eye for descemetocele with impending risk of perforation.


Bilateral corneal infiltrates after excimer laser photorefractive keratectomy.


Others as well may see a similar rise based on local trends in TB infection and disease.


In severe cardiogenic shock, the patient required an extracorporeal membrane-oxygenation system for 8 days until cardiac recovery.


The patient was discharged on the 8th postoperative week in good conditions.


A previously unreported complication of the use of prostaglandin analog medications for glaucoma therapy is described.


Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.


Self induced photosensitive epilepsy.


The theophylline level was 9.89 micrograms/ml at the moment of psychotic reaction.


Therefore, black cohosh-induced fluid retention and coagulation activation should be considered in differential diagnosis, especially if thrombosis has been excluded.


Recent efforts have focused on heightened surveillance to detect contamination before transfusion to limit recipient morbidity and mortality.


We report the case of a child with metastatic osteosarcoma, who experienced an anaphylactic/anaphylactoid reaction to methotrexate.


Phenol is a neurolytic agent that is widely used by percutaneous retrogasserian injection in the treatment of trigeminal neuralgia.


[2] Neither LPS nor VVR increased lung water, but LPS decreased MCTV in both normal airways (31%) and VVR-exposed airways (30%; p = 0.03), and VVR increased MCTV by 34% in LPS-inflamed airways (p = 0.002).


The treatment of amputee residual limb pain can at times be a challenge for the physician.


We report the impact on the patient management of two liver biopsies, which diagnosed an initial drug induced hepatitis and subsequently an atypical HCV related hepatitis.


She delivered a healthy child vaginally under epidural anaesthesia.


After the episode, 1 patient continued to receive d-penicillamine therapy and 2 changed to zinc sulfate treatment.


A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.


By a combination of appropriate selection of medications and an awareness of delirium as a side effect, the patient in the ICU may be treated in a manner to minimize the clouding of consciousness.


Darifenacin is a muscarinic antagonist which was FDA approved for the treatment of overactive bladder in December 2004.


As linezolid has been shown to have hematologic side effects, blood count monitoring is recommended in patients receiving this drug for long-term therapy.


After this period, liposomal amphotericin B (3 mg kg(-1) day(-1)) was given with the diagnosis of probable fungal infection.


Nonetheless, the results of therapy with many of the treatment programs described are encouraging, as exemplified by the report from Graboys and coworkers.


Acute lymphoblastic leukemia (ALL) is uncommon in this patient population, and Philadelphia chromosome positive (Ph+) ALL in particular, is rare.


Here, we report a giant cell lichenoid dermatitis in a 41-year-old male patient who developed, 3 days after intravenous treatment with amoxicillin-clavulanic acid for erysipelas of the left leg, a clinical picture suggesting a baboon syndrome characterized by an erythematous and pruritic eruption on the axillary, inguinal and popliteal areas and the anterior side of elbows.


CONCLUSIONS: These results suggest that clozapine may cause TD; however, the prevalence is low and the severity is relatively mild, with no or mild self-reported discomfort.


The most striking and severe symptom was burning of the trunk and proximal extremities, occurring in 11 patients.


Oxcarbazepine, a carbamazepine analog, was approved for use as an antiepileptic agent in the United States in 2000.


The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies.


The patient recovered completely from his liver injury, but the sicca complex persisted 1 yr after the drug was given.


The drug was tolerated without evident toxicity, though an unpleasant taste and nausea at high doses were limiting.


METHODS: A 20-year-old woman developed pain, redness, decreased vision, and corneal infiltrate in the right eye 15 days after bilateral LASIK.


Herein is reported an unusual case of coexistent warfarin-induced skin necrosis and heparin-induced thrombocytopenia following mitral valve replacement for thromboembolic phenomena associated with marantic endocarditis and bronchial adenocarcinoma.


This case report describes the diagnostic workup in a child with anaplastic ependymoma and inconclusive MRI (magnetic resonance imaging) and PET (positron emission tomography) findings.


Spacers have evolved from simple monoblock designs made of acrylic cement alone to articulated, modular, complex and expensive designs with different grades of constriction.


A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.


Leflunomide was started.


Although preemptive therapy with ganciclovir prevented successfully severe CMV diseases and CMV-related mortality, a patient developed persistent positive CMV antigenemia for more than 1 year after transplantation and CMV disease, despite the use of ganciclovir and foscarnet.


Intralesional injection of 5-fluorouracil has recently been reported as a possible method of treatment for an assortment of benign and malignant cutaneous neoplasms.


A case of Lactobacillus casei endocarditis that occurred on a Carpentier-Edwards porcine valve is reported.


To date, this is the first reported case of what appears to be isolated thrombocytopenia associated with lansoprazole.


The patients required admission for assessment of the severity of the overdose in addition to advice about appropriate use of analgesics and advice on access to dental care.


Electron microscopy demonstrated electron-dense granules, free and membrane-bound, within macrophages and fibroblast-like cells.


A patient bleeding from oesophageal varices in whom injection sclerotherapy failed to control bleeding required peripheral vein vasopressin infusion for a total of five days.


We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.


Her drug therapy also included nicergoline 30 mg/day, amlodipine 5 mg/day, aspirin 100 mg/day, candesartan 16 mg/day, and atenolol 25 mg/day.


This paper discusses the importance of critical care and emergency nurses having an understanding of why pre-existing cardiac disorders can influence antiarrhythmic treatment.


Through a literature search, we were able to identify 4 additional cases of therapy-related AML in AIDS patients following chemotherapy for lymphomas.


Two pediatric oncology patients with Ewing's sarcoma and one with mixed germ cell tumor were treated with drug regimens that included bleomycin or cyclophosphamide.


Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.


Despite significantly reduced plasma insulin concentrations, glucose tolerance did not deteriorate.


The parasite may remain in the host for over 25 years before immunosuppression causes either dissemination or hyperinfection.


This paralleled the rise in the number of children with tuberculous infection and disease seen at our institution, from an average 96 per year to 213 per year during these two time periods.


The patient presented with loss of consciousness and died after 5 days of antifungal therapy with liposomal amphotericin B.


A case of SIADH induced by mizoribin administration.


The association of central diabetes insipidus (CDI) with lithium use is rare.


Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from the uterus.


The clinical course of a 9-year-old diagnosed with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and Tourette's disorder and treated with a combination of methylphenidate, clonidine, and fluoxetine is described.


The microbiologic diagnosis was established after valvectomy, which was necessitated by failure of empiric antibiotics to eradicate the infection.


OBJECTIVE: To report a case of chronic, nonproductive cough secondary to the angiotensin-converting enzyme (ACE) inhibitor quinapril, with complete resolution after switching to another ACE inhibitor, fosinopril.


An 11-year-old, 25-kg girl with congenital myelomeningocele was scheduled for posterior spinal fusion because of progressive scoliosis.


Sustained monomorphic ventricular tachycardia after adenosine infusion.


Either primary headaches show a higher susceptibility to this idiosyncratic reaction or a drug-induced primary headache evolves in intensity and duration, becoming uncontrolled until the complete discontinuation of the drug in consideration.


Hospitalized patients with HIV disease (n = 42) during this same period, demonstrated an increased prevalence of QT, prolongation (28.6%, P = 0.002).


We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).


These lesions developed within the port site during the radiation treatments (11 cases) or soon after (nine cases) its completion (mean: 16 days; range: 2-35).


Cytomegalovirus colitis after autologous transplantation for multiple myeloma.


After intensive treatment with topical corticosteroids, the DLK resolved during the following 2 weeks.


A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.


Pediatricians rarely use a systematic approach to establish the cause of drug reactions in the clinical setting.


Infection of central nervous system by motile Enterococcus: first case report.


Complement factor H (FH) deficiency is one of the causes of atypical hemolytic uremic syndrome (HUS).


The case of a 86-year-old woman with obstructive ileus due to advanced pancreatic cancer is presented.


We describe a patient with M4 AML treated with standard chemotherapy followed by G-CSF who developed marked monocytosis on day 8 of G-CSF therapy.


T. mucoides is a rare cause of systemic infection.


We experienced a male patient with psoriasis and hypertension whose conditions were treated with tacalcitol ointment and thiazide, respectively, resulting in hypercalciuria and hypercalcemia.


In addition, patients should be closely monitored for a possible delayed interaction that may occur with each repeated cycle of 5-fluorouracil chemotherapy.


At the same time, physicians cannot yet rely solely on a genetic diagnosis because we have not yet identified a sufficient spectrum of mutations, and it is not currently feasible to examine every patient's full DNA sequence for the entire gene; screening an ethnically consistent and clinically positive patient for the 8 known mutations frequently identifies a mutation on only 1 chromosome, and genetic analysis of other classic cases will often reveal none of the 8 mutations.


Association of zomepirac administration with renal cortical necrosis is not known to have been previously demonstrated.


The gastrointestinal arterial bleeding from the penetrating aneurysm presented a life-threatening situation.


METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.


Reversal reaction to Hansen's disease.


Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus.


Cannabis for chronic pain: case series and implications for clinicians.


Gastrointestinal haemorrhage necessitated the use of misoprostol.


Total parenteral nutrition was continued without the fat emulsion and symptoms and signs disappeared.


Sputum in the three cases failed to reveal acid-fast bacilli, pathogenic fungi, or opportunistic organisms by cultures and appropriate stains.


We report a case of secondary glaucoma caused by epithelial downgrowth in which filtration surgery was performed with adjunctive use of subconjunctival 5-fluorouracil.


One day later, the INR was found to have decreased, and bleeding was also improved.


Chryseobacterium indologenes bacteraemia in a diabetic child.


It is used alone or in combination with other lipid-lowering agents in the treatment of various forms of hypercholesterolemia.


Two cases of long term dopamine D2 receptor blockade after depot neuroleptics.


The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).


Successful treatment of poison oak dermatitis treated with Grindelia spp. (Gumweed).


Serratia Marcescens corneal ulcer as a complication of orthokeratology.


Due to the severity of the disease it was necessary to treat this patient with corticosteroids and immunosuppressors.


Peak serum concentrations exceeded 4 mcg/ml.


Embolia cutis medicamentosa (ECM) is a rare side effect observed primarily after intramuscular injections.


This suggests the possibility that ACE inhibitors may uncover an asthmatic tendency in patients with pre-existing bronchial hyperreactivity.


L-asparaginase-induced posterior reversible encephalopathy syndrome during acute lymphoblastic leukemia treatment in children.


Carboplatin was substituted for cisplatin, and there were no further episodes of SIADH.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


Calcium hopantenate is a pantothenic acid antagonist.


These data suggest that clots can form on surfaces coated with the Carmeda process, even if a low dosage of heparin is used.


Our case is compared with other cases previously reported.


Sodium thiosulfate in the treatment of tumoral calcifications in a hemodialysis patient without hyperparathyroidism.


Acute dystonic reaction with low-dose pimozide.


Adverse reactions to systemic corticosteroids rarely occur and the etiology is unclear in most cases.


Despite an extensive evaluation, which included a gallium scan, a technetium bone scan, and abdominal ultrasound, a source could not be found.


Trying to adjust the treatment to the patient's requirements, Carbamazepine together with Oxybutynin and Dantrolene was readministrated in lower doses.


We believe that a pharmacodynamic interaction is most likely.


Data derives from a qualitative interview study and a cross-sectional survey of 518 patients, with all patients receiving out-patient cancer chemotherapy in Sweden.


METHODS: Two patients underwent highly selective CDT after delayed presentation (>5 days) of flap compromise.


Methotrexate-induced hepatic necrosis requiring liver transplantation in a patient with rheumatoid arthritis.


In addition, severe oedema of the right upper eyelid was observed.


Culture from the bone abscess gave growth of mycobacteria which could not be distinguished from BCG.


Substitution of olanzapine with aripiprazole further exacerbated the problem.


Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature.


To the best of our knowledge only two previous cases of AML have been linked to treatment of HCL with purine analogs, both with 2-chlorodeoxyadenosine.


Investigations showed peripheral blood eosinophilia with thoracocentesis revealing eosinophilic exudative pleural effusion.


A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.


Renal biopsy demonstrated lesions characteristic of rapidly progressive glomerulonephritis with minor interstitial changes.


A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.


Haemodialysis patients are likely to develop bacteriaemia due to S. aureus, probably because they are often carriers of S. aureus and also frequently have intravascular catheters.


Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.


Therefore, care should be given to prescribing clarithromycin for patients receiving carbamazepine.


The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.


This is a report of prolonged meningitis caused by echovirus type 20 in a patient with rhabdomyosarcoma.


The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.


Dystonia associated with carbamazepine administration: experience in brain-damaged children.


Fungal septicaemia in patients with cystic fibrosis associated with totally implantable venous access device system.


Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.


The newer generation of antifungal agents such as itraconazole and terbinafine are more effective than the older therapies, griseofulvin and ketoconazole, in the treatment of dermatophyte pedal onychomycosis.


We describe a patient who had a systemic allergic contact dermatitis to 8-MOP develop during her second course of PUVA treatment for psoriasis.


The resultant warfarin dose required to maintain a therapeutic INR was 45 mg/wk, a 63.6% dosage increase after the initiation of bosentan.


The case also highlights the increased cardiovascular morbidity in testicular cancer survivors and evokes the possibility of mechanisms of myocardial ischemia other than atherosclerotic disease in these young patients.


A causal relationship between the administration of halothane and clinical improvement is suggested.


Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).


We describe a 5-month-old infant who had fever of unknown origin leading to an exhaustive evaluation during a 7-week period.


Strict neurological supervision of patients treated with chlorambucil is recommended.


The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).


Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.


Acute interstitial pneumonia induced by ONO-1078 (pranlukast), a leukotriene receptor antagonist.


Hepatobiliary scans using Tc-IDA are reliable in making the diagnosis of acute cholecystitis.


The toxicity and plasma concentrations of ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were then determined over 24 h after a single 1.6 g/m2 dose of ifosfamide.


De novo hypertension after liver transplantation.


One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward.


A medical-legal review regarding the standard of care for epidural injections, with particular reference to a closed case.


This case report describes a patient who was previously prescribed alendronate (Fosamax) and presented with postoperative hypophosphatemia and hypocalcemic tetany after bowel preparation with Fleet Phospho-Soda.


Electro-oculography, electroretinography, visual evoked potentials, and multifocal electroretinography in patients with vigabatrin-attributed visual field constriction.


Both phenotypic and genotypic virologic analysis was performed on sequential CMV isolates.


We report a case of papillary necrosis in a patient treated with indinavir.


There was a striking temporal relationship between the administration of antibiotics or allopurinol and exacerbations of the disease.


Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.


RESULTS: The average time of presentation was 9 days, with the average time to CDT being 9.5 days.


The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity.


This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine.


The mortality rate associated with respiratory failure due to invasive fungal infections after allogeneic hematopoietic stem cell transplantation (HSCT) is exceedingly high.


None of the side effects observed resisted treatment or was severe enough to warrant discontinuation of therapy.


Spontaneous improvement of tardive dystonia during mania.


One hundred forty-eight (59%) of 251 patients with spinal cord injury who were evaluated had received this drug.


Leukemia relapse occurred 82 days later.


Four case reports and a critical commentary on the use of vitamin D in these disorders.


Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.


A pattern of possible risk factors emerges from these reports.


One should pay attention to the abdominal wall around the needle track in interpreting CT or MR images of patients with previous PEI.


We report a patient with severe Crohn's disease and the short bowel syndrome on parenteral feeding who was not responding to conventional therapy and underwent treatment with cyclosporin (CyA) given initially intravenously and subsequently orally in each of two courses.


In two patients this was the sole chemotherapeutic agent used.


These findings lend further evidence for anticonvulsant teratogenicity.


Adrenal crisis was assumed and during therapy with hydrocortisone infusion, the patient recovered.


Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.


Although serologic tests for Epstein-Barr virus (EBV) indicated a previous infection, EBV deoxyribonucleic acid was detected in her serum by polymerase chain reaction.


Periodic alternating nystagmus in phenytoin intoxication.


This report supports the findings of others regarding the potential toxicity of topical ester-type local anesthetics.


In both patients the carcinoma developed on areas not usually exposed to sunlight.


In the instances that it does occur, previous liver disease or failure to be abstinent from alcohol are thought to be causative.


However, the patient continued to deteriorate and developed CMV pneumonitis.


Patients with metastatic breast carcinoma and similar presentations should be considered for prophylactic therapy with allopurinol and hydration before chemotherapy.


Possible pathophysiological mechanisms which may have been operative in this case include: a direct central nervous system (CNS) toxic effect of valproic acid; a paradoxical epileptogenic effect secondary to the drug; and an indirect CNS toxic effect mediated through valproic acid-induced hyperammonemia.


Serum electrolyte and creatinine levels remained within normal limits.


Fourteen months after the second stenting, a new elective angiogram was performed without evidence of in-stent restenosis.


CASE SUMMARY: A 65-year-old patient chronically treated with the selective serotonin reuptake inhibitor (SSRI) citalopram developed confusion, agitation, tachycardia, tremors, myoclonic jerks and unsteady gait, consistent with serotonin syndrome, following initiation of fentanyl, and all symptoms and signs resolved following discontinuation of fentanyl.


To the best of our knowledge no comparable case and no discussion of possible complications of aspirin prophylaxis in patients with brain tumours have been published.


After discontinuing the HCQ, the QT interval was shorter and the patient recovered after treatment with lidocaine and isoproterenol.


Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.


Cystoid macular edema responds to intravitreal triamcinolone and rebounds after intravitreal bevacizumab.


We report a 7 year old boy, who developed clinical and echocardiographical findings of pericardial constriction 5 weeks after a cardiac surgery, which resolved with steroid therapy.


We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.


Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients.


Botulinum toxin for palliative treatment of epiphora in a patient with canalicular obstruction.


Administration of intravenous nitroglycerin in a patient with idiopathic pulmonary hypertension resulted in an increase in pulmonary artery pressure associated with a decrease in blood flow that is best explained by an increase in pulmonary vascular resistance.


By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.


Further injections were followed by similar symptoms in addition to paraesthesiae and altered pin-prick sensation of anterior thigh and legs with no residual deficit.


High-dose corticosteroids were given with a return to baseline pulmonary function.


We report a case of a 35-year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode.


The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.


MANAGEMENT: Potassium supplementation, sodium bicarbonate therapy, intravenous fluid therapy and dialysis.


The pharmaceutical company producing Halfan has reported 8 cardiac arrests, leading to 6 deaths, when a higher dose than recommended was used, there was recent or concomitant treatment with mefloquine, there was pre-existing prolongation of the QT interval or the patient had a thiamine deficiency.


Although there is a presumed drug-drug interaction between itraconazole and nonnucleoside reverse-transcriptase inhibitors, the medical literature lacks such documentation.


Analysis and correlation of antenatal data and drug therapy with individual cases failed to show any specific abnormality that could reasonably be attributed to zidovudine therapy.


METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.


Synergistic effect of carbapenem-teicoplanin combination during severe Rhodococcus equi pneumonia in a kidney transplant recipient.


The considerable exposure to chemicals, time course and unusual pattern of organ involvement suggested a diagnosis of occupational scleroderma.


When prescribing mannitol to decrease intraocular pressure, the physician must be alert to potential complications.


These symptoms did not recur after discontinuation of the drug.


Once the diagnosis of acute cerebral infarction is confirmed, thrombolytic therapy should be administrated within the time window of 3 hours.


They have lipid levels drawn annually and are seen by both an endocrinologist and a flight surgeon for general medical examinations.


CASE SUMMARY: A 66-year-old man with a background history of breast carcinoma was admitted with pleuritic chest pain.


Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.


Fifteen patients presented between January 1986 and January 1991 with deterioration in renal function coincident with the introduction of angiotensin converting enzyme inhibitors.


While both amiodarone and digoxin can cause permanent visual changes, the ocular effects are often reversible.


Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.


BACKGROUND: The antimycotic synthetic azole compounds are known to lead to toxic liver injury.


Gadolinium enhancement of anterior lumbosacral spinal nerve roots was demonstrated in all three patients, and an elevation of cerebrospinal fluid immunoglobulin G synthesis was evident in two patients with more severe symptoms.


Pulmonary leukostasis secondary to all-trans retinoic acid in the treatment of acute promyelocytic leukemia in first relapse.


A wide range of autoimmune disorders have been described in DiGeorge syndrome and velocardiofacial syndrome, including one prior report of autoimmune hemolytic anemia and immune thrombocytopenia.


Steroid therapy improved the airways of the other 8 patients.


Better appetite was subjectively noted by 81% of patients.


Concurrent use of reteplase and lepirudin in the treatment of acute anterior wall myocardial infarction.


However, brain metastasis was diagnosed.


The patient presented to the emergency department with a few weeks' history of irritability, constipation and intermittent vomiting.


In patients with occult hepatitis B virus (HBV) infection, acute exacerbation may occur when they become immunocompromised.


Aliskiren-associated acute renal failure with hyperkalemia.


We discuss the potential mechanisms associated to OXC and status migrainosus, drug-induced headaches and uncontrolled headaches.


Laryngeal dyspnea in relation to an interaction between acenocoumarol and topical econazole lotion.


We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.


Both recovered after 10 days of intraperitoneal administration of cefazolin and tobramycin.


Five days after discharge (day 1), she developed bilateral lower extremity arterial thrombi and underwent heparinization and successful lower extremity thrombectomies.


Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.


Treatment with ketamine met with moderate success, and then large doses of lorazepam and midazalam were used.


Abemayor).


OBJECTIVE: To evaluate the simple medication regimen, all psychotropics were given at night for patients with chronic schizophrenia, who had been taking them at least twice a day for more than 12 weeks before the entry.


We describe the clinical course, renal function, and blood viral measurement in 6 renal transplant recipients with BKVN who were treated with low doses of cidofovir.


Imaging findings were compatible with left maxillary, ethmoidal, and sphenoidal sinusitis.


It is not certain to what extent drug therapy, physiological and metabolic changes consequent on prolonged seizures, hitherto undiscovered infective agents, or a combination of any of these may play in such a process.


Before desensitization, the proportion of CFSElow CD4+ cells in whole CD4+ was 3.09%; 13.6% of CFSElow CD4+ cells were stained with anti-interferon gamma antibody.


A 56-year-old white woman with a diagnosis of reactive depression developed severe UI after a 30 days' treatment with venlafaxine 75 mg/day.


In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.


OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.


We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis.


A 47-year-old male with bipolar I disorder/hallucinations presented to the Veterans Affairs Medical Center (VAMC) with suicidal ideations.


The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.


They are usually localized reactions such as ecchymoses, erythematous plaques, and nodules.


The nasal challenge test with a calcitonin nasal spray, up to 150 UI, was negative.


We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.


Diagnosis of DPD deficiency must be confirmed by specialized laboratory tests.


Her best-corrected visual acuity was 0.9 in the right (RE) and 1.0 in the left eye (LE).


Cytogenetic studies of the bone marrow performed after the development of acute leukemia showed chromosome abnormalities in all five patients examined, with hypodiploidy and loss of B and C group chromosomes.


Diagnosis of toxoplasmosis was confirmed by muscle biopsy and seroconversion.


Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.


METHOD: In an effort to refine MAOI dietary recommendations, we report a case of hypertensive crisis following the consumption of a modest amount of tap beer.


The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.


Two separate blood cultures yielded C. indologenes.


Fungal peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD) has been associated with high mortality and high CAPD-discontinuation rates.


CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.


Hypoxia was documented in one case and probably present in the other.


Broad-spectrum antibiotic therapy and percutaneous abscess drainage under the guidance of computed tomography resulted in a satisfactory resolution of the abscess.


This potential long-term risk has medicolegal implications for informed consent and for the potential use of both permanent fillers and interferon.


On the third day, zafirlukast (20 mg twice daily) was reintroduced to the regimen, and the theophylline therapy was continued.


The overall toxicity is substantially less than standard induction chemotherapy, with the notable exception of deaths attributed to the development of pulmonary leukostasis coinciding with a rapid increase in the number of mature neutrophils.


It is of interest that all of his teeth were extremely large and subsequently showed severe crowding in the dental arches.


METHODS: We present the clinical and laboratory findings and describe the clinical course of our patient.


The reversal of symptoms and radiographic demonstration of relief of obstruction after oral steroid therapy are discussed.


Although the possibility of this interaction has been noted, no previously documented occurrence of this interaction has been identified.


The chimeric anti-CD20 monoclonal antibody, rituximab, is a promising treatment for cutaneous B-cell lymphomas.


Review of the current literature confirms the importance of 3D dose planning in avoiding this complication and high-lights the role of MRI in establishing the diagnosis of radiation-induced optic neuropathy.


Clinicians have been aware of lithium toxicity for many years and traditionally have administered thiazide diuretics for lithium-induced polyuria and nephrogenic diabetes insipidus.


METHODS: No reports describing alcohol neurolysis of the superior cluneal nerve exist in the relevant literature.


CONCLUSION: To our knowledge, this is the first case report of delayed onset of cerebral infarction caused by an embolism after CPS fixation.


INTRODUCTION: Significant decreases in tumour recurrence rates of up to 50% are reported after one immediate postoperative instillation of chemotherapeutic drugs, such as epirubicin or mitomycin C.


Thiazolidinedione-induced edema.


Biopsy taken from the site did not reveal any granulomatous or atrophic changes and cultures of the biopsy did not yield any organism.


Post-transfusion purpura as the main manifestation of a trilineal transfusion reaction, responsive to steroids: flow-cytometric investigation of granulocyte and platelet antibodies.


After the remission of the hypoalbuminemia and thrombocytopenia, the macular edema observed by OCT disappeared and visual acuity returned to normal.


Cerebral angiography disclosed occlusions and narrowing of both internal carotid arteries at the supraclinoid portions, where multiple cysts were found on the MRI.


Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.


Additional drugs present included hydrocodone and morphine (nonconjugated) at 0.16 and 0.04 microg/mL, respectively.


Possible interactions between the putatively hyperactive dopaminergic system and corticosteroids are discussed.


This is the third report of reversible hepatic decompensation associated with prolonged MTX therapy in patients with rheumatoid arthritis.


RESULTS: Ethambutol, and to a lesser extent isoniazid, are both implicated in the development of visually related side effects.


A 40-year-old man had undergone instrumented posterior lumbar interbody fusion at the L5/S1 level approximately 1 year previously.


Careful consideration must be made of the choice of environment in which intravenous loading is done (e.g., emergency department, intensive care unit), as dictated by patient parameters, nursing staff levels, and planned disposition.


We report one case each of CAPD-related peritonitis caused by Aspergillus terreus and Mucor sp., which have previously been described in the literature once and twice, respectively.


Two heroin addicts, aged 34 and 19 years, developed ballistic movements after intravenous heroin overdose.


If it is used for diagnostic purposes, resuscitative equipment should be readily available.


In these patients, long-acting octreotide may trigger serious hypoglycemia.


Therapeutic options to treat this dangerous imbalance comprise calcium gluconate, insulin plus glucose, albuterol/salbutamol inhalation.


5-Azacytidine and fetal hemoglobin.


In our patient, an objective causality scale showed that therapeutic doses of colchicine for FMF were the definite cause of myopathy, even though his renal and hepatic function were normal.


AIM: To report a patient with diabetic rubeosis who suffered from acute retinal ischemic change and stroke after intravitreal injection of bevacizumab.


Possible risk of invasive pulmonary aspergillosis with marijuana use during chemotherapy for small cell lung cancer.


Examination of the bronchoalveolar lavage fluid revealed an increased eosinophil count.


Hepatitis C virus RNA was negative after 12 mo of treatment.


Subsequent radiologic examination revealed rachitic bone and joint changes.


Clearly, more effective therapies are needed for this rapidly lethal disease.


The mechanism behind this observation may be similar to that of previously reported protease inhibitor-associated fat redistribution, but instead involving the adipose tissue of discrete uncommon benign tumors.


We here report on two patients who received imatinib in the presence of increased bilirubin and/or cholestasis parameters.


We suspect a possible cause-and-effect relationship, which has not previously been reported in the literature.


The patient had received methotrexate alone for more than 10 years without any signs of severe liver damage.


The VPA concentration following this dose escalation was 392 micromol/L, and the patient improved clinically.


The first patient developed a histologically documented acute hepatitis and recovered after 3 weeks.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


A 17-year-old anuric female patient with end-stage renal failure received a massive overdose of vancomycin and was treated with high-flux hemodiafiltration, as described in this report.


Aminoglycoside-induced renal toxicity is well known and may manifest with nonoliguric renal failure or renal tubular dysfunction.


A 74-year-old man with well-compensated systolic dysfunction and longstanding type 2 diabetes mellitus treated with glyburide began therapy with rosiglitazone 4 mg/day, which was increased to 8 mg/day after 1 month.


He was admitted to the hospital for treatment after failing to improve on oral ciprofloxacin and inhaled tobramycin.


A 57-year-old woman with end-stage renal disease presumed secondary to chronic glomerulonephritis underwent a living related renal allograft transplantation.


Aortic transgraft hemorrhage is an unusual complication following thrombolytic therapy that can occur months to years after aortic surgery.


A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide.


The clinical picture was characterized by visual hallucinations, agitation, anxiety, but no disorientation, and a severe cerebello-myoclonic syndrome with total inability to stand up and walk, which was fully reversible on discontinuing the medication.


As emergency surgical intervention of thrombotic prosthetic cardiac valves is correlated with high mortality, fibrinolytic therapy has been recently recommended as a therapy with high efficacy and no severe side effects.


Candida dubliniensis is an emerging fungal pathogen, especially in immunodeficient patients.


Vancomycin administration led to a good outcome for this patient.


In this case series, the course of mild to severe OHSS was evaluated in 19 intact twin pregnancies after IVF/ICSI.


We present a case of an abscess in this site which was a complication of chemotherapy and was the result of haematogenous spread.


He underwent uneventful cataract extraction surgery and intraocular lens implantation of the right eye.


BACKGROUND: Platinum-based chemotherapy agents have been associated with potentially fatal acute immune-mediated hemolytic anemia.


Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain.


Two patients with RAS responded with a rise in haemoglobin concentration to > 130 g/l.


Immunophenotyping these lesions revealed a dense LCA+, CD2+, CD3+, CD4+, CD5+, CD7+, CD45+, CD45RO+ T-cell infiltrate admixed with many factor XIIIa+ dendrocytes.


He required intensive treatment and support for 13 days.


We present a case of a newly acquired herpetic infection in the graft after penetrating keratoplasty.


Review of the literature relating to methicillin-induced nephropathy suggests a hypersensitivity origin for this disorder, but immunologic and ultrastructural investigation to date has failed to elucidate pathogenesis.


In order to develop optimal schedules for exogenous TPO administration it might be important to consider endogenous TPO response characteristics.


Intravenous haloperidol is generally well tolerated, but multiform ventricular tachycardia has been reported.


A rare case of advanced ovarian carcinoma who developed difficulty walking 25 days after treatment with weekly paclitaxel.


Cerebral sinus thrombosis associated with acquired free protein S deficiency is very rare.


Therapy was discontinued at a cumulative dose of adriamycin of 600 mg/m2.


He underwent hospital admission, early intubation, intensive care for nine days and hospitalization for six weeks.


Behavioral side effects associated with clonazepam may include agitation, aggression, hyperactivity, irritability, property destruction, and temper tantrums.


Proposed mechanisms include von Willebrand Factor abnormalities, decreased prostacyclin production, and immune complex formation.


MEASUREMENTS AND MAIN RESULTS: A patient recovering from acute respiratory distress syndrome developed septic shock from Pseudomonas aeruginosa bacteremia while in the medical intensive care unit.


RESULTS: Onset of symptoms of infection occurred after a mean of 20 days (range, 11 days-6 weeks) after LASIK or an enhancement procedure.


The third patient had been suffering from serious akathisia while on risperidone, and was cured after switching to olanzapine, but thereafter the patient suffered from RLS at nighttime.


Clozapine was approved by the U.S.


A striking feature of the neoplasms was cholestasis.


Magnetic resonance spectra provided a noninvasive means of monitoring CNS response.


The most-common ocular symptom is colored rings around lights.


Intractable severe bleeding from his oral mucositis necessitated treatment with a continuous infusion of 8-ornithine-vasopressin for 8 days.


Teamwork and skillful airway management prevented this patient's demise.


She was treated with methylprednisolone (40 mg i.v. q6h), aminophylline (loading with 5 mg/kg and maintained with 0.6 mg/kg/hr i.v. drip), nebulized terbutaline sulphate (5 mg q6h), oral procaterol 12.5 micrograms bid, along with oxygen therapy.


Tolerance of sunitinib in dialyzed patients with metastatic renal cell carcinoma.


Disseminated fusariosis.


Also, he developed similar signs and symptoms when he was administered tobramycin intravenously on one occasion at 5 1/2 years.


This report suggests that anemia can occur due to MMF, in particular when it is given with prednisone, a side effect well documented in the transplantation literature when the triple combination of MMF, cyclosporine and prednisone is used.


RESULTS: Two of three melanoma patients had objective responses.


These measurements (720 before and 832 on therapy) suggested that both early and late dumping symptoms are causally related to the rate of glucose elevation and decline, rather than to glucose peak and nadir, respectively.


PURPOSE: To illustrate the multiple causes of hypoxemia to be considered following cardiopulmonary bypass and how therapy given to improve oxygen delivery may have contributed to a decrease in arterial oxygen saturation to life-threatening levels.


Case histories, including medication lists, liver biopsy and laboratory data were reviewed.


This report describes a case of fatal haemolytic uraemic syndrome (HUS) developing in a child with acute lymphoblastic leukaemia (ALL) during induction chemotherapy.


Gastric stump lymphoma after distal gastrectomy for benign peptic ulcer: Report of a case.


Clonidine: a practical guide for usage in children.


MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction.


The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid.


CASE SUMMARIES: In each case, the patients were treated over 5 years with lovastatin and developed rhabdomyolysis that coincided with the completion of a prescribed regimen of a newer macrolide antibiotic.


Interaction between methotrexate and ciprofloxacin.


In 6 dogs with multicentric lymphosarcoma, salmonellosis developed shortly after the start of anticancer chemotherapy.


After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.


Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.


Bilateral ear infections, central nervous system lymphoma and infection, or other drug-induced neuropathies were excluded as possible etiologies for the deafness.


He was kept for observation, recovered well, and was discharged with prescriptions for prednisone and diphenhydramine hydrochloride.


Treatment consisted of catecholamines and repetitive infusions of Ringer lactate.


Again, the pneumonitis was fully reversible.


It was concluded that potassium loss occurred by a non-renal (intestinal) route in phosphate-induced hypokalemia.


Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.


It's much better now and I have more energy." Such comments justify our efforts on our patients' behalf.


It has also been advocated as an intervention for diagnostic use to assess uncommon types of tachycardia.


Although renal function showed gradual improvement after seven days of anuria, the recovery was slow and incomplete.


Liposomal amphotericin B in drug-resistant visceral leishmaniasis.


For the treatment of secondary hyperparathyroidism (HPTH-II) in dialysis patients and hypercalcemia in patients with parathyroid carcinoma.


As a clinical entity atrioventricular (AV) block due to hypothyroidism is rare.


Exceptionally long status and stupor increase the risk of medical complications.


However, its clinical utility in CMV treatment has not been described previously.


RESULTS: The patients sought treatment ten to 20 weeks (mean, 15 weeks) postoperatively.


Given that psychiatric symptoms are not included in the manufacturer's lists of adverse drug reactions, the incidence may be significantly higher.


A 33-year-old male presented with brown discolouration of the fingernails following the application of 4% hydroquinone in sorbolene cream and 0.1% tretinoin cream to the face intermittently for 9 months.


Irinotecan is metabolized by carboxylesterase to form an active SN-38, which is further conjugated and detoxified by UDP-glucuronosyltransferase (UGT) to yield its beta-glucuronide.


In such cases, conservative, nonsurgical measures, such as treatment with botulinum toxin, will provide excellent results.


After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension.


This helped us to find a proper therapeutic strategy for our patient.


To our knowledge, its drug-related occurrence has not been previously reported.


After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.


parvovirus B19 was assumed to induce the leukopenia by restraining myeloid proliferation.


Autopsy findings are discussed of a 23-month-old child exposed in utero to anticonvulsant therapy.


Here we report our experience with BC infection in four patients with acute leukemia or related disorders.


The infiltrate slowly resolved with topical antibiotics, and the best corrected visual acuity improved to 20/20.


Therefore, appropriate management of these behaviors seems necessary.


Verrucae plantaris--effective treatment with bleomycin: review of the literature and case presentations.


The authors describe the many disease and treatment-related causes for pain in patients with HIV disease, as well as common neurologic conditions that alter cognition and complicate the use of opioids.


We report a case of ST elevation in right precordial leads compatible with type 1 Brugada syndrome following administration of propafenone in a patient with Wolff-Parkinson-White syndrome who was receiving lithium at concentrations within therapeutic levels.


The mean duration of clozapine treatment was 12.10+/-6.26 years.


If epidural analgesia is used, opioids may be preferred over local anaesthetics in the immediate postoperative period to prevent masking of an anterior spinal artery syndrome.


After 2 months, antibiotic therapy was continued with one drug.


This treatment has the potential to cause severe vision loss as a result of intractable corticosteroid-induced glaucoma.


The management of this patient (aggressive surgical debridement and prolonged wound care) is reviewed as well as the review of the underlying processes.


In this report, we review the pathophysiology of PLP and treatment options.


Pisa syndrome in a cohort of Alzheimer's disease patients.


During clarithromycin coadministration, four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine, such as drowsiness, dizziness, and ataxia, which resolved within 5 days after clarithromycin discontinuation.


We report a case of ruptured abdominal aortic aneurysm (AAA) in a patient receiving chemotherapy for pancreatic cancer.


Heavy pre- and post-transplant immunosuppression is a major risk factor for invasive fungal infection, which can involve remote organs and manifest in an indolent and atypical manner.


A 29-year-old man had continued treatment with anti-epileptic drugs under the diagnosis of epilepsy for 13 years.


Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal.


CONCLUSION: Marked visual field constriction appears to be associated with vigabatrin therapy.


Thereafter, the FK506 concentration in whole blood gradually decreased, and the hyperkalaemia and metabolic acidosis following RTA improved.


Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.


Auto-intoxication with flecainide and quinapril: ECG-changes, symptoms and treatment.


General anesthesia was induced.


Factors that suggested an association between the severe angioedematous reaction and BP topical application include the strong reaction to BP in the patch-test, the temporal relationship, the complete resolution of symptoms after the drug was withdrawn and the absence of other identified explanations.


Patients were followed up every 2 weeks after the laser treatment.


The gynecomastia regressed when the theophylline was discontinued.


Probable early acute hepatitis with parenteral amiodarone.


DISCUSSION: Several different agents are currently available to provide effective anticoagulation in patients who have immune- mediated HIT.


Tamoxifen side effects, age-related macular degeneration (AMD) or cancer associated retinopathy (CAR)?


Recurrent septicemia with lethal outcome during and after cyclosporine therapy in severe ulcerative colitis.


A patient experienced methadone withdrawal symptoms when combining these agents.


There are, however, case studies describing patients experiencing recurrences of tics following treatment with atomoxetine.


Approximately 75%-85% of patients with bladder cancer present with disease confined to the mucosa (stage Ta-CIS) or submucosa (stage T1).


A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy.


Although gabapentin withdrawal has been previously reported and usually consists of anxiety, diaphoresis, and palpitations, this is the first reported patient with generalized seizures and status epilepticus secondary to gabapentin withdrawal.


The second case, a 16-year-old African-American male with an absolute CD4+ cell count of 895 cells/mm3, presented with rickets and hypophosphatemia while receiving TDF-based HAART.


Due to relatively well preserved cellular immunity until 2003, no antiretroviral therapy (HAART) needed to be instituted.


A greater than 50% decrease in red cell transfusion requirement was observed in one patient with RA and one patient with AA.


Vaccination scar with soft-tissue atrophy restored by local insulin treatment.


CONCLUSIONS: This is the first report of a possible interaction between propafenone and citalopram, which caused propafenone adverse effects (eg, dizziness, falls) and mimicked coronary artery disease.


The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.


Report of two cases, personal experience and review of the literature.


When co-trimoxazole was stopped the red cell aplasia resolved.


He remained on a steady dose of 8000 mg/day for 9 months, almost doubled what is considered therapeutic.


Tc-99m labelled anti CD 66 antigranulocyte antibody imaging for assessment of bone marrow reserve.


In contrast, ultrarapid metabolizers with multiple CYP2D6 genes might require high doses of such drugs for optimal therapy.


Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.


Immunopathology detected in situ bound and circulating immunoglobulin G (IgG) autoantibodies to epithelial cell surfaces and circulating IgG autoantibodies against desmoglein 1.


Starting dosages were 134 and 201 mg/day, and were increased to 268 mg/day in both patients.


Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis.


These findings should lead to further study of the role of lithium in the treatment of this symptom complex in patients with PTSD.


A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.


The our case of patient with von Willebrand's disease type I indicates that this drug is very effective in bleeding after teeth extractions.


The mother, applied hot compresses for 16 hours, starting 6.5 hours after the injection.


Disabling errors of skin keratinization.


CONCLUSIONS: Cefazolin was a probable cause of this patient's leukopenia.


This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk.


OBJECTIVES: To discuss the mechanism by which epidermal growth factor receptor (EGFR)-targeted agents work, the resulting cutaneous toxicities, the pathophysiology of the unique rash associated with these agents, and the management of these skin problems.


Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).


During the past 10 y, 25 children with a mean age of 2 y were admitted for clonidine intoxication.


Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.


The authors report five additional cases of capecitabine-induced multifocal leukoencephalopathy.


No neurological deficits occurred during the further course of the disease.


Its duration of action is brief and serious adverse effects have not been reported.


Oesophageal ulceration due to emepronium bromide.


Clinical examination revealed no evidence of vasculitis nor coagulopathy and initial neuroimaging (i.e., computed tomography, angiography, magnetic resonance imaging) demonstrated no features consistent with aneurysm, arteriovenous malformation (AVM), cavernoma, nor cerebral metastases.


In 1995 his blood pressure became difficult to control despite a sequential increase in his antihypertensive medication dosages and the addition of new medications.


Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.


This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.


We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.


This might be due to the fact that it has also been used to treat bacterial meningitis from organisms like Listeria monocytogenes, which is a common pathogen in the elderly and in infants.


The final visual acuity was 1.0 in both eyes.


Both cases had classical symptoms of Youssef's syndrome, i.e. cyclic hematuria, absence of vaginal bleeding and complete urinary continence.


A 22-year-old man with a synovial cell sarcoma attained an excellent response to therapy with adriamycin (NSC-123127) and dimethyltriazeno imidazole carboxamide (NSC-45388).


Data suggest that addition of amphetamine to varenicline may negate the partial agonism of varenicline, resulting in elimination of the smoking-cessation aid's benefits.


A rechallenge 3 months later caused similar pulmonary symptoms, confirming the association between the drug and the respiratory system.


RESULTS: The patient was seen on the eighth postoperative day with endophthalmitis that responded to medical treatment.


Methanol metabolism was effectively blocked by fomepizole even after ethanol had been eliminated, and the patient recovered 20/20 vision by day 14 with normal fundoscopy.


It should be emphasized that this syndrome may occur after irradiation and chemotherapy in patients with nasopharyngeal cancer.


OBJECTIVE: To evaluate the efficacy of the administration of insulin by a jet-injector device in stopping and reversing severe human insulin-induced lipoatrophy.


A 12-year-old, spayed female keeshond presenting with lethargy, anorexia, weight loss, and vomiting was diagnosed with multicentric lymphoma.


It is suggested that dopaminergic imbalance, as opposed to excessive dopaminergic blockade, may also play a role in the precipitation of NMS.


CONCLUSION: The contraction-associated hypofluorescence line, namely marginal crack line, indicates the early damage of retinal pigment epithelium and seems to lead to expanding macular chorioretinal atrophy typically seen in mCNV.


The muscle rigidity and hyperpyrexia were unresponsive to intravenous benztropine but resolved within one hour of intravenous dantrolene 2 mg/kg.


Cardiovascular, pulmonary, and neurologic complications also occur frequently.


Malignant hyperthermia (MH) in humans is usually triggered by volatile anaesthetics and depolarizing muscle relaxants.


Discontinuation of etanercept led to control of heart function.


Two patients who developed cholestatic liver disease after exposure to antibiotics are described.


Simple-blind oral challenge tests with amoxicillin (1 g) and cefuroxime (500 mg) were well-tolerated by both patients.


Not your typical pneumonia: a case of exogenous lipoid pneumonia.


This women was assessed yearly by ultrasonography and Pap smear.


Discontinuation of the statin improved his symptoms.


An adult male presented with central blindness after ingesting methanol.