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README.md
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#
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[](https://opensource.org/licenses/MIT)
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- Shares some clinical features with ME/CFS
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- Similarly lacks definitive biomarkers and is diagnosed primarily by clinical assessment
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## Data Processing Guidelines
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To process this methylation data, we recommend the following pipeline:
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1. **Quality Control**:
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- Filter out probes on sex chromosomes
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- Remove known polymorphic or cross-reactive probes
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- Perform sample quality checks (detection p-values, intensity distributions)
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2. **Normalization**:
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- Beta-value calculation
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- BMIQ normalization for type I/II bias correction
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- Optional: ComBat batch correction if combining multiple datasets
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3. **Feature Selection**:
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- Differential methylation analysis to identify disease-associated CpG sites
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- Optional: Variance filtering to remove low-variability probes
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4. **Analysis**:
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- Recommended: Apply the Epigenomic Transformer Pipeline or similar methods
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- Alternative approaches: Logistic regression, random forest, XGBoost
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## Usage Example
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Here's a simple example of how to load and process this data using the `minfi` package in R:
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densityPlot(beta_norm, sampGroups=targets$Group)
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```
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## Research Applications
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This dataset is suitable for:
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1. Developing and validating diagnostic classifiers for ME/CFS and Long COVID
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2. Identifying epigenetic biomarkers specific to each condition
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3. Studying the biological mechanisms underlying these post-viral illnesses
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4. Comparing epigenetic patterns between ME/CFS and Long COVID
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5. Training machine learning models for disease classification
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## Citation Information
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If you use this dataset in your research, please cite:
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## Additional Resources
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For more information about the Epigenomic Transformer Pipeline developed using this data, please visit our [GitHub repository](https
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## Acknowledgements
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# Transformer Attention Heads in Epigenetics of ME/CFS and Long COVID
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[](https://opensource.org/licenses/MIT)
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- Shares some clinical features with ME/CFS
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- Similarly lacks definitive biomarkers and is diagnosed primarily by clinical assessment
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## Usage Example
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Here's a simple example of how to load and process this data using the `minfi` package in R:
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densityPlot(beta_norm, sampGroups=targets$Group)
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```
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## Citation Information
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If you use this dataset in your research, please cite:
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## Additional Resources
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For more information about the Epigenomic Transformer Pipeline developed using this data, please visit our [GitHub repository](https:github.com/VerisimilitudeX/EpiMECoV).
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## Acknowledgements
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