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22,705,133 | 2012-11-20 | 2012-07-03 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Rate of re-bleeding of arteriovenous malformations in the first year after rupture. | Gross Bradley A, Du Rose | eng | null | Journal Article | null | IM | 22705133, S0967-5868(12)00020-3, 10.1016/j.jocn.2011.12.005 | Prior rupture is an established risk factor for subsequent hemorrhage from arteriovenous malformations (AVM). Recent natural history studies have reinvigorated the important concept that the re-bleed rate is not constant; rather, it is particularly greater in the first year after hemorrhage. In this study, we reviewed our own cohort of 129 patients with AVMs. Eighty-one presented with hemorrhage (63%), and of these patients, 38 had at least one month of subsequent clinical follow-up and were included in our analysis. Over a total of 140 patient-years, the annual re-hemorrhage rate was 7.9%, though it was 15.8% in the first year. Two-thirds of those AVM that hemorrhaged in the first year were associated with aneurysms. The overall permanent morbidity of re-hemorrhage was 45%; the mortality rate was 9%. Although the re-hemorrhage rate in the first year varied from 6% to 15.8% across series in the literature, it was generally double the overall re-hemorrhage rate provided in each study. These results have significant therapeutic implications, favoring surgical treatment of ruptured AVM and/or their associated aneurysm when feasible to avoid the incumbent greater risk of early rehemorrhage. | Adult, Arteriovenous Malformations, Cohort Studies, Female, Hemorrhage, Humans, Male, Retrospective Studies | null |
22,705,134 | 2012-11-20 | 2012-07-03 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Traumatic and spontaneous carotid and vertebral artery dissection in a level 1 trauma center. | Lleva P, Ahluwalia B S, Marks S, Sahni R, Tenner M, Risucci D A, Lai H M, Li J | eng | null | Journal Article | null | IM | 22705134, S0967-5868(12)00021-5, 10.1016/j.jocn.2011.11.018 | This study aimed to compare traumatic and spontaneous carotid artery dissection (CAD) and vertebral artery dissection (VAD) with respect to age, pre-morbid risk factors, and site of dissection. Chart review was performed for 49 patients with CAD and VAD admitted to Westchester Medical Center, a level 1 trauma center, from 1999 to 2007. Presentation was categorized into traumatic (n=28, 57%) or spontaneous dissection (n=21, 43%). Pre-morbid risk factors were analyzed. Location of dissection was identified and categorized into four possible segments. Patients with spontaneous dissection were likely to be over the age of 50 years (p<0.05), and had significantly higher proportions of coronary artery disease (33% compared to 7%, p<0.05), hypertension (57% compared to 18%; p<0.01), and hypercholesterolemia (29% compared to 0%; p<0.01). Of the 49 patients, 42 had imaging studies available for segmental analysis. In both traumatic CAD and VAD, dissection at Segment III (corresponds with the first and second cervical vertebrae), was the most common site (37.5% and 50%, respectively, p<0.05). In contrast, Segment I (origin of the vessel to the fifth cervical vertebrae) was the most common site for spontaneous CAD and VAD (55% and 77%, respectively, p<0.05). This cross-sectional study suggests that etiology plays an important role in the location of dissection. Traumatic CAD and VAD occur most commonly in Segment III. Spontaneous CAD and VAD occur most commonly in Segment I and are associated with increasing age and premorbid cerebrovascular risk factors. | Adult, Carotid Artery, Internal, Dissection, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Risk Factors, Tomography, X-Ray Computed, Trauma Centers, Vertebral Artery Dissection | null |
22,705,135 | 2012-11-20 | 2012-07-03 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Lumboperitoneal shunts for the treatment of normal pressure hydrocephalus. | Bloch Orin, McDermott Michael W | eng | null | Journal Article | null | IM | 22705135, S0967-5868(12)00022-7, 10.1016/j.jocn.2011.11.019 | Ventriculoperitoneal shunt placement is the standard of care for idiopathic normal pressure hydrocephalus (iNPH). Studies have reported shunt complication rates up to 38%, with subdural hemorrhage rates as high as 10%. Lumboperitoneal (LP) shunts with horizontal-vertical valves (HVV) are an alternative for cerebrospinal fluid (CSF) diversion that avoids direct cerebral injury and may reduce the risk of overdrainage. Here we reviewed our experience with LP-HVV shunt placement for iNPH. We retrospectively reviewed our 33 patients with LP-HVV shunts inserted for the treatment of iNPH from 1998 to 2009. Patients were evaluated for improvements in gait, urinary function, and dementia after shunt placement. All patients had evidence of ventriculomegaly and a positive response to pre-operative lumbar puncture or extended lumbar drainage. All 33 (100%) patients had pre-operative gait dysfunction, 28 (85%) had incontinence, and 20 (61%) had memory deficits. Mean follow-up time was 19 months. Following shunt placement, 33/33 (100%) patients demonstrated improved gait, 13/28 (46%) had improvement in incontinence, and 11/20 (55%) had improvement in memory. Shunt failures requiring revision occurred in nine patients (27%), with an average time to failure of 11 months. Infections occurred in two patients (6%). There were no neurologic complications, including no hemorrhages. Thus, LP-HVV shunt placement is a safe and effective alternative to ventriculoperitoneal shunting for iNPH, resulting in significant symptomatic improvement with a low risk of overdrainage. It should be considered as an option for the treatment of patients with iNPH who demonstrate clinical improvement following lumbar drainage. | Aged, Aged, 80 and over, Female, Gait Disorders, Neurologic, Humans, Hydrocephalus, Normal Pressure, Longitudinal Studies, Lumbosacral Region, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Ventriculoperitoneal Shunt | null |
22,705,136 | 2012-12-27 | 2012-08-13 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Reliability and diagnostic characteristics of clinical tests of upper limb motor function. | Amer M, Hubert G, Sullivan S J, Herbison P, Franz E A, Hammond-Tooke G D | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705136, S0967-5868(12)00029-X, 10.1016/j.jocn.2011.12.007 | There is a paucity of information on the inter-rater reliability and predictive value of components of the neurological examination. Selected tests of upper limb motor function were studied in 34 patients with Parkinson's disease, upper motor neuron disease or cerebellar disease and in 25 control participants. Video recordings were independently evaluated and scored by two clinicians to determine inter-rater reliability (kappa) and predictive values. Kappa values ranged from 0.00 to 0.73. Highest positive predictive values (PPV) were obtained for the Barré test, arm raise, forearm rolling and finger nose tests. Negative predictive values (NPV) were mostly low, with highest values for unimanual sequential finger tap and rhythmic tap. The combined tests had PPV of 0.58 and NPV of 0.73. This study demonstrates that these clinical tests have poor inter-rater reliability and low negative predictive value when used in isolation. | Adult, Aged, Aged, 80 and over, Arm, Cerebellar Diseases, Female, Fingers, Functional Laterality, Hand, Hand Strength, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Neuron Disease, Movement Disorders, Muscle Strength, Neuroimaging, Neurologic Examination, Observer Variation, Parkinson Disease, Predictive Value of Tests, Psychomotor Performance, Reproducibility of Results, Upper Extremity | null |
22,705,137 | 2012-12-27 | 2022-03-18 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | The application of a radiographically determined ratio as a new technique to identify the optimal level of transverse skin incision for anterior cervical spine surgery. | Leonard Michael, Kennedy Cian, Heneghan Helen, Cabe John Mc | eng | null | Journal Article | null | IM | 22705137, S0967-5868(12)00028-8, 10.1016/j.jocn.2011.12.006 | A transverse skin incision for anterior cervical spine surgery gives an excellent cosmetic result but is not extensile, thus accuracy of incision placement is essential. We describe a new, fast and inexpensive method of accurate transverse skin incision placement that does not rely on anatomical landmarks or intraoperative fluoroscopy. A ratio, determined by measurements from a lateral cervical spine radiograph, was applied to measurements on the patients' neck to determine the site for incision. The use of a ratio was designed to remove any inaccuracies related to X-ray magnification differences. A retrospective review of 54 consecutive anterior cervical spine procedures undertaken with this technique was performed. The operative level ranged from C2-C3 to C7-T1, the most common being C5-C6. Post-operative radiographic measurement of the incision site (marked by skin clips) demonstrated a mean distance of 5 mm (range 1-8 mm) from the centre of the skin clips to the predetermined ideal midpoint for each individual. In no case was it necessary to radically extend or to make a separate incision. The technique described is an accurate method of determining the level of transverse skin incision placement for cervical spine surgery that reduces intra-operative fluoroscopy time, radiation dose and expense. | Adult, Aged, Aged, 80 and over, Cervical Vertebrae, Diskectomy, Female, Humans, Male, Middle Aged, Neurosurgical Procedures, Postoperative Complications, Retrospective Studies, Skin, Spinal Fusion, Spine, Tomography, X-Ray Computed, Total Disc Replacement, Treatment Outcome | null |
22,705,138 | 2012-11-20 | 2012-07-03 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Spontaneous low pressure headache - a review and illustrative patient. | Lahoria Rajat, Allport Louise, Glenn Derek, Masters Lynette, Shnier Ron, Davies Mark, Hersch Mark | eng | null | Case Reports, Journal Article, Review | null | IM | 22705138, S0967-5868(12)00076-8, 10.1016/j.jocn.2011.12.014 | Low pressure headache typically occurs as a complication of dural puncture. "Spontaneous" low pressure headache is a relatively rare but under-recognised cause of intractable headache. Clinical suspicion of this condition warrants imaging of the brain to confirm the diagnosis; spinal imaging may be needed to identify the site of the leak. Epidural blood patching may be necessary to seal the leak - CT fluoroscopy may be helpful in delivering the patch directly to the site of the leak. Surgical intervention may be required in intractable cases. We describe a patient with spontaneous intracranial hypotension and review the clinical and radiological features of this syndrome. | Adult, Brain, Female, Headache, Humans, Intracranial Hypotension, Magnetic Resonance Imaging, Myography, Spinal Cord | null |
22,705,139 | 2013-03-07 | 2022-04-09 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | A longitudinal study of sensory biomarkers of progression in patients with diabetic peripheral neuropathy using skin biopsies. | Narayanaswamy H, Facer P, Misra V P, Timmers M, Byttebier G, Meert T, Anand P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Biomarkers, GAP-43 Protein, TRPV Cation Channels, TRPV1 protein, human, Histamine | IM | 22705139, S0967-5868(12)00200-7, 10.1016/j.jocn.2011.12.026 | We aimed to identify biomarkers in skin punch biopsies that could be used to monitor progression of diabetic peripheral neuropathy (DPN), and, in future studies, to assess the efficacy of agents that may reduce progression. Patients with DPN were studied with clinical assessments, skin biopsies, quantitative sensory testing (QST), histamine-induced skin flare, nerve conduction studies and contact heat-evoked potentials (CHEPS). Skin biopsies were performed on two visits with a 6 month interval (n=29 patients) to quantify intraepidermal (IENF) and subepidermal (SENF) nerve fibres immunoreactive for: protein gene product 9.5 (PGP9.5), a pan-neuronal marker; transient receptor potential cation channel vanilloid 1 (TRPV1), the heat and capsaicin receptor; and growth associated protein-43 (GAP-43), a marker of regenerating fibres. The IENF were counted along the length of four non-consecutive sections, and results were expressed as fibres per millimetre length of section. SENF were measured by image analysis, and the area of highlighted immunoreactivity was obtained as a percentage (% area) of the field scanned. QST, skin flare and CHEPS were also performed at the two visits. We found that IENF and SENF were significantly reduced for both PGP9.5 and TRPV1 between the first and second skin biopsy over 6months. The annual rate ± standard error of the mean of IENF loss was 3.76 ± 1.46 fibres/mm for PGP9.5, and 3.13 ± 0.58 fibres/mm for TRPV1. The other tests did not show significant changes. Strongly positive GAP-43 nerve fibres were found in deep dermis in the patients with diabetes, even in those with an absence of IENF. We conclude that PGP9.5 and TRPV1 IENF and SENF in skin biopsies are useful markers of progression in DPN, whereas GAP-43 SENF could potentially help detect nerve regeneration in severe neuropathy. | Adult, Aged, Biomarkers, Biopsy, Diabetic Neuropathies, Disease Progression, Evoked Potentials, Female, GAP-43 Protein, Histamine, Hot Temperature, Humans, Immunohistochemistry, Longitudinal Studies, Male, Middle Aged, Neural Conduction, Neurologic Examination, Pain Measurement, Peripheral Nervous System Diseases, Sensation, Skin, TRPV Cation Channels, Vibration | null |
22,705,141 | 2012-11-20 | 2012-07-03 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | The relationship between arm dystonia in corticobasal degeneration and handedness. | Rana Abdul Qayyum, Ansari Hamza, Siddiqui Ishraq | eng | null | Journal Article | null | IM | 22705141, S0967-5868(12)00011-2, 10.1016/j.jocn.2011.10.012 | Corticobasal degeneration is a progressive neurodegenerative disease involving the cerebral cortex and basal ganglia and leads primarily to motor symptoms and cognitive dysfunction. Unilateral arm dystonia is a common presenting symptom in many patients with corticobasal degeneration. This study attempts to determine if a relationship exists between arm dystonia in corticobasal degeneration and the handedness of the patient. A chart review of 12 right-handed patients (six males and six females) diagnosed with corticobasal degeneration seen in a Parkinson's disease clinic was conducted. With the exception of a single individual who was afflicted in her dominant arm, all had dystonia in their left arm. The ages of the female patients were substantially lower than their male counterparts. Although the sample size of the patient population is small, the results raise an interesting question: is arm dystonia in corticobasal degeneration more commonly seen on the contralateral side of the dominant hand. Further observation is needed to establish a correlation. | Age Factors, Aged, Aged, 80 and over, Arm, Basal Ganglia Diseases, Dystonia, Female, Functional Laterality, Humans, Male, Middle Aged, Sex Factors | null |
22,705,140 | 2012-11-20 | 2019-12-10 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Analysis of data from the CDC/FDA vaccine adverse event reporting system (1990-2009) on Guillain-Barre syndrome after hepatitis vaccination in the USA. | Souayah Nizar, Yacoub Hussam A, Khan Hafiz M R, Farhad Khosro, Maybodi Leila, Qureshi Adnan I, Menkes Daniel L | eng | null | Journal Article | Influenza Vaccines | IM | 22705140, S0967-5868(12)00025-2, 10.1016/j.jocn.2011.11.022 | We used data from the Vaccine Adverse Event Reporting System, supplemented by additional data provided by the Center for Biologics Evaluation and Research, to identify 189 patients with Guillain-Barré syndrome (GBS) reported after hepatitis vaccination with a mean age of 30.65 years, affecting men and women equally. Among vaccinated patients, 133 (70%) developed GBS within six weeks, 30 (15.9%) after six weeks, and for the remaining 26 (13.7%), the time between GBS occurrence and vaccination was not specified. The reporting rate of post-hepatitis vaccine GBS is approximately 3.4 cases per one million vaccinations, which is in the range expected in the general population. The unbalanced distribution of reports in the first six weeks after vaccination suggests that some cases of GBS may be triggered by vaccination. Nonetheless, the low incidence of hepatitis vaccine-associated GBS, and the dramatic incidence reduction of hepatitis and its complications after vaccination, support the current guidelines for vaccination. | Adolescent, Adult, Adverse Drug Reaction Reporting Systems, Centers for Disease Control and Prevention, U.S., Child, Female, Guillain-Barre Syndrome, Humans, Incidence, Influenza Vaccines, Male, Retrospective Studies, Time Factors, United States, United States Food and Drug Administration, Young Adult | null |
22,705,142 | 2012-11-20 | 2022-03-18 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Hearing preservation after LINAC radiosurgery and LINAC radiotherapy for vestibular schwannoma. | Fong Brendan M, Pezeshkian Patrick, Nagasawa Daniel T, De Salles Antonio, Gopen Quinton, Yang Isaac | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | null | IM | 22705142, S0967-5868(12)00068-9, 10.1016/j.jocn.2012.01.015 | Linear accelerators (LINAC) can deliver both radiosurgery and fractionated radiotherapy. In this systematic analysis, we compare hearing preservation in patients with vestibular schwannomas (VS) treated with either LINAC-based radiotherapy (SRT) or LINAC-based radiosurgery (SRS), with an emphasis on the prognostic implications of tumor size and patient age. A total of 400 patients met our criteria for LINAC SRS, with an average hearing preservation rate of 66.3%. Patients with smaller tumors (<3.0 cm(3)) treated with SRS had similar hearing preservation rates to those with larger tumors. However, younger patients (<55 years) demonstrated improved hearing preservation compared to older patients (≥55 years). When comparing LINAC SRS to LINAC SRT directly, hearing preservation was similar in patients with smaller tumors. However, patients with larger tumors (≥3.0cm(3)) who received SRT had higher hearing preservation rates than those who received SRS. A total of 629 patients met our criteria for LINAC SRT, with an average hearing preservation rate of 75.3%. Patients with larger tumors who received SRT had better hearing outcomes than those with smaller tumors, while there was no significant difference in hearing preservation in younger patients compared to older patients. When comparing LINAC SRS to LINAC SRT directly, younger patients had similar hearing preservation rates. However, older patients who received SRT had improved hearing preservation compared to those who received SRS. In a direct comparison of average hearing preservation, patients who received SRT had higher hearing preservation rates than those who underwent SRS. Prospective studies will be needed to further characterize radiation dose and other variables. | Databases, Factual, Hearing, Humans, Meta-Analysis as Topic, Neuroma, Acoustic, Radiation Oncology, Radiosurgery, Recovery of Function | null |
22,705,143 | 2012-11-20 | 2013-11-21 | 1532-2653 | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | Open-label study of combination therapy with isoniazid for management of refractory neuropathic pain. | Feng Yanqing, Guo Ning, Sun Qiaosong, Chen Xi, Liu Junxiu, Lai Rong, Huang Fan | eng | null | Journal Article | Anticonvulsants, Fatty Acid Synthesis Inhibitors, Isoniazid | IM | 22705143, S0967-5868(12)00012-4, 10.1016/j.jocn.2011.09.034 | Although there have been improvements in treatment, neuropathic pain often remains unresponsive to all treatment modalities. This pilot study assessed the efficacy of combination therapy with isoniazid for the treatment of intractable neuropathic pain. We conducted this prospective, open-label, add-on study in 45 consecutive patients who suffered from treatment-refractory neuropathic pain. The patients were given combination therapy with 8 mg/kg of isoniazid and were followed for a minimum of eight weeks. Pain relief was recorded using the visual analogue scale (VAS) score. Secondary measures included sleep interference scores and the Patient Global Impression of Change (PGIC) scale. There was a significant decrease in the mean VAS score following eight weeks of treatment compared with the baseline. In addition, PGIC and mean sleep score also improved. This study suggests that combination therapy with isoniazid has potent analgesic properties and may therefore be useful in the management of intractable neuropathic pain. | Adult, Aged, Anticonvulsants, Drug Therapy, Combination, Fatty Acid Synthesis Inhibitors, Female, Follow-Up Studies, Humans, Isoniazid, Male, Middle Aged, Neuralgia, Pain Measurement, Pilot Projects, Young Adult | null |
22,705,145 | 2012-12-17 | 2016-11-25 | 1095-8584 | Journal of molecular and cellular cardiology | Interaction of the cardiovascular risk marker asymmetric dimethylarginine (ADMA) with the human cationic amino acid transporter 1 (CAT1). | Strobel Joachim, Mieth Maren, Endress Beate, Auge Daniel, König Jörg, Fromm Martin F, Maas Renke | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Biomarkers, Cationic Amino Acid Transporter 1, N,N-dimethylarginine, Metformin, Arginine | IM | 22705145, S0022-2828(12)00214-3, 10.1016/j.yjmcc.2012.06.002 | Elevated plasma concentrations of endogenously formed asymmetric (ADMA) and symmetric dimethyl-l-arginine (SDMA) are associated with adverse clinical outcomes. Our aim was to investigate the cellular uptake properties of ADMA by the human cationic amino acid transporter 1 (CAT1; SLC7A1). Human embryonic kidney cells (HEK293) stably overexpressing CAT1 (HEK-CAT1) and vector-transfected control cells (HEK-VC) were established to determine cellular uptake of labeled [(3)H]ADMA and [(3)H]l-arginine. Uptake of ADMA and l-arginine were significantly (p<0.001) higher in HEK-CAT1 than in HEK-VC at all investigated concentrations. Apparent V(max) values of cellular ADMA and l-arginine uptake by CAT1 were 26.9 ± 0.8 and 11.0 ± 0.2 nmol mg protein(-1) min(-1), respectively. K(m) values were 183 ± 21 μmoll(-1) (ADMA) and 519 ± 36 μmoll(-1) (l-arginine). Uptake of ADMA was inhibited by l-arginine and SDMA with IC(50) values (95% CI) of 227 (69-742) μmoll(-1) and 273 (191-390) μmoll(-1), respectively. ADMA and SDMA inhibited CAT1-mediated uptake of l-arginine with IC(50) values of 758 (460-1251) μmoll(-1) and 789 (481-1295) μmoll(-1), respectively. Efflux of ADMA was significantly increased in HEK-CAT1 cells as compared to HEK-VC (p<0.05). CAT1 mediates the cellular uptake of ADMA. In its physiological concentration range ADMA is unlikely to impair CAT1-mediated transport of l-arginine. Conversely, high (but still physiological) concentrations of l-arginine can inhibit CAT1-mediated cellular uptake of ADMA. | Arginine, Biological Transport, Biomarkers, Cardiovascular Diseases, Cationic Amino Acid Transporter 1, Gene Expression, HEK293 Cells, Humans, Kinesics, Metformin, Risk | null |
22,705,146 | 2013-04-04 | 2023-11-04 | 1873-6815 | Experimental gerontology | Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain. | Thal Dietmar Rudolf, Grinberg Lea Tenenholz, Attems Johannes | eng | P50 AG023501 (NIA NIH HHS, United States); 1R01AG040311-01A1 (NIA NIH HHS, United States); R01 AG040311 (NIA NIH HHS, United States); R173/1110 (The Dunhill Medical Trust, United Kingdom); G1100540 (Medical Research Council, United Kingdom); G0900652 (Medical Research Council, United Kingdom); 2P50 AG023501-06 (NIA NIH HHS, United States); G0400074 (Medical Research Council, United Kingdom); G0502157 (Medical Research Council, United Kingdom) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review | null | IM | 22705146, S0531-5565(12)00153-2, 10.1016/j.exger.2012.05.023, PMC3470831, NIHMS386557, 10807728, 6375662, 20946241, 22410648, 12154250, 20595656, 21778438, 20204386, 3487952, 19225789, 22341035, 2011243, 10202244, 20155424, 1759558, 1763890, 3893019, 22705312, 11403164, 22377814, 9736023, 10952063, 22133276, 17717316, 22385790, 18525132, 10570203, 19521084, 11935038, 21422755, 22301385, 22426770, 15100718, 8878478, 19260033, 12154256, 11089571, 16957923, 16917086, 22390883, 15211074, 10926944, 18716559, 12417364, 19161908, 14512367, 21956727, 4135618, 16866990, 19349602, 3159021, 16170565, 8094895, 3963770, 19483658, 12146804, 1258104, 7604429, 18369648, 20846674, 11222652, 17469117, 11770901, 9330961, 6823683, 22944481, 18624777, 7670967, 18359131, 22002422, 21706175, 22162060, 19749406, 14692704, 19578713, 10489957, 5505685, 12480742, 11005257, 20396480, 18208483, 8414012, 15885064, 22265587, 1699693, 22101365, 22170742, 20920816, 1381856, 17719631, 8181179, 1632466, 21940957, 12084879, 19002474, 3415200, 8786397, 3941328 | The diagnosis of vascular dementia (VaD) describes a group of various vessel disorders with different types of vascular lesions that finally contribute to the development of dementia. Most common forms of VaD in the elderly brain are subcortical vascular encephalopathy, strategic infarct dementia, and the multi infarct encephalopathy. Hereditary forms of VaD are rare. Most common is the cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Sporadic forms of VaD are caused by degenerative vessel disorders such as atherosclerosis, small vessel disease (SVD) including small vessel arteriosclerosis, arteriolosclerosis, and lipohyalinosis, and cerebral amyloid angiopathy (CAA). Less frequently inflammatory vessel disorders and tumor-associated vessel lesions (e.g. angiocentric T-cell or angiotropic large cell lymphoma) can cause symptoms of dementia. Here, we review and discuss the impact of vessel disorders to distinct vascular brain tissue lesions and to the development of dementia in elderly individuals. The impact of coexisting neurodegenerative pathology in the elderly brain to VaD as well as the correlation between SVD and CAA expansion in the brain parenchyma with that of Alzheimer's disease (AD)-related pathology is highlighted. We conclude that "pure" VaD is rare and most frequently caused by infarctions. However, there is a significant contribution of vascular lesions and vessel pathology to the development of dementia that may go beyond tissue damage due to vascular lesions. Insufficient blood blow and alterations of the perivascular drainage mechanisms of the brain may also lead to a reduced protein clearance from extracellular space and subsequent increase of proteins in the brain parenchyma, such as the amyloid β-protein, and foster, thereby, the development of AD-related neurodegeneration. As such, it seems to be important for clinical practice to consider treatment of potentially coexisting AD pathology in cognitively impaired patients with vascular lesions. | Aged, Aged, 80 and over, Alzheimer Disease, Arteriosclerosis, Blood Vessels, Brain, Cerebral Amyloid Angiopathy, Dementia, Vascular, Female, Humans, Male, Middle Aged | null |
22,705,147 | 2012-12-17 | 2018-12-01 | 1873-2763 | Bone | Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway. | Yue Li, Durand Marianne, Lebeau Jacob M Christian, Hogan Philippe, McManus Stephen, Roux Sophie, de Brum-Fernandes Artur J | eng | MOP89786 (Canadian Institutes of Health Research, Canada) | Journal Article, Research Support, Non-U.S. Gov't | Isoenzymes, Receptors, Immunologic, Receptors, Prostaglandin, Acid Phosphatase, Tartrate-Resistant Acid Phosphatase, Caspases, Prostaglandin D2, prostaglandin D2 receptor | IM | 22705147, S8756-3282(12)00926-X, 10.1016/j.bone.2012.06.003 | Prostaglandin D(2) (PGD(2)) is a lipid mediator synthesized from arachidonic acid that directly activates two specific receptors, the D-type prostanoid (DP) receptor and chemoattractant receptor homologous molecule expressed on T-helper type 2 cells (CRTH2). PGD(2) can affect bone metabolism by influencing both osteoblast and osteoclast (OC) functions, both cells involved in bone remodeling and in in vivo fracture repair as well. The objective of the present study was to determine the effects of PGD(2), acting through its two specific receptors, on human OC apoptosis. Human OCs were differentiated in vitro from peripheral blood mononuclear cells in the presence of receptor activator for nuclear factor κB ligand (RANKL) and macrophage-colony stimulating factor (M-CSF), and treated with PGD(2), its specific agonists and antagonists. Treatment with PGD(2) for 24hours in the presence of naproxen (10μM) to inhibit endogenous prostaglandin production increased the percentage of apoptotic OCs in a dose-dependent manner, as did the specific CRTH2 agonist compound DK-PGD(2) but not the DP agonist compound BW 245C. In the absence of naproxen, the CRTH2 antagonist compound CAY 10471 reduced OC apoptosis rate but the DP antagonist BW A868C had no effect. The induction of PGD(2)-CRTH2 dependent apoptosis was associated with the activation of caspase-9, but not caspase-8, leading to caspase-3 cleavage. These data show that PGD(2) induces human OC apoptosis through activation of CRTH2 and the apoptosis intrinsic pathway. | Acid Phosphatase, Apoptosis, Blotting, Western, Caspases, Cell Differentiation, Humans, Isoenzymes, Osteoclasts, Prostaglandin D2, Receptors, Immunologic, Receptors, Prostaglandin, Serum, Signal Transduction, Staining and Labeling, Tartrate-Resistant Acid Phosphatase | null |
22,705,149 | 2012-12-17 | 2021-10-21 | 1873-2763 | Bone | Automated threshold-independent cortex segmentation by 3D-texture analysis of HR-pQCT scans. | Valentinitsch Alexander, Patsch Janina M, Deutschmann Julia, Schueller-Weidekamm Claudia, Resch Heinrich, Kainberger Franz, Langs Georg | eng | P 22578 (Austrian Science Fund FWF, Austria) | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705149, S8756-3282(12)00928-3, 10.1016/j.bone.2012.06.005 | The quantitative assessment of metabolic bone diseases relies on tissue properties such as bone mineral density (BMD) and bone microarchitecture. In spite of an increasing number of publications using high-resolution peripheral quantitative computed-tomography (HR-pQCT), the accurate and reproducible separation of cortical and trabecular bone remains challenging. In this paper, we present a novel, fully automated, threshold-independent technique for the segmentation of cortical and trabecular bone in HR-pQCT scans. This novel post-processing method is based on modeling appearance characteristics from manually annotated cases. In our experiments the algorithm automatically selected texture features with high differentiating power and trained a classifier to separate cortical and trabecular bone. From this mask, cortical thickness and tissue volume could be calculated with high accuracy. The overlap between the proposed threshold-independent segmentation tool (TIST) and manual contouring was 0.904±0.045 (Dice coefficient). In our experiments, TIST obtained higher overall accuracy in our measurements than other techniques. | Aged, Aged, 80 and over, Algorithms, Automation, Female, Humans, Imaging, Three-Dimensional, Male, Middle Aged, Organ Size, Radius, Regression Analysis, Tissue Donors, Tomography, X-Ray Computed | null |
22,705,150 | 2013-01-24 | 2015-11-19 | 1095-9254 | Journal of adolescence | Adolescents who self-harm: professional staff knowledge, attitudes and training needs. | Timson Debbie, Priest Helena, Clark-Carter David | eng | null | Journal Article | null | IM | 22705150, S0140-1971(12)00078-4, 10.1016/j.adolescence.2012.05.001 | This study aimed to investigate professional staff attitudes and knowledge about adolescents who engage in self-harming behaviour and to identify training needs. Previous research has suggested that medical and health care staff perceptions may reinforce the stigma associated with such behaviour and therefore jeopardise the effectiveness of interventions. To date, no available research exists on the views of school teachers. Participants recruited for the study were 120 qualified professionals working within an Accident and Emergency Department (A&E), Child & Adolescent Mental Health Services (CAMHS) and a Secondary School, based within the West Midlands, United Kingdom. Results demonstrated statistically significant differences between the groups. CAMHS staff were more knowledgeable and felt more effective than either A&E staff or teachers, whereas A&E staff expressed more negative attitudes. 95% of all staff reported that they would benefit from further training. These findings are discussed in relation to practice issues. | Adolescent, Factor Analysis, Statistical, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Self-Injurious Behavior, Surveys and Questionnaires | null |
22,705,148 | 2012-12-17 | 2016-11-25 | 1873-2763 | Bone | Mild to moderate cognitive impairment is a major risk factor for mortality and nursing home admission in the first year after hip fracture. | Schaller F, Sidelnikov E, Theiler R, Egli A, Staehelin H B, Dick W, Dawson-Hughes B, Grob D, Platz A, Can U, Bischoff-Ferrari H A | eng | null | Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | null | IM | 22705148, S8756-3282(12)00927-1, 10.1016/j.bone.2012.06.004 | It is not well established if and to what extent mild to moderate cognitive impairment predicts mortality and risk of nursing home admission after hip fracture. | Aged, 80 and over, Cognitive Dysfunction, Female, Hip Fractures, Hospitalization, Humans, Male, Nursing Homes, Risk Factors, Survival Analysis, Switzerland | null |
22,705,144 | 2013-02-05 | 2016-11-25 | 1878-0938 | Cardiovascular revascularization medicine : including molecular interventions | Dramatic improvement in hypoxemic respiratory failure after patent foramen ovale closure in a patient with obesity hypoventilation syndrome. | Mehrotra Amit K, Cork David P, Weiss Sandra A, Shah Atman P | eng | null | Case Reports, Journal Article | null | IM | 22705144, S1553-8389(12)00155-8, 10.1016/j.carrev.2012.05.002 | We report a case of a patient with pulmonary hypertension who presented with acute hypoxemic respiratory failure. The patient had continued refractory hypoxemia despite a prolonged ICU admission that included ventilatory support, and empiric therapy for pulmonary embolism and pneumonia. Transthoracic echocardiography (TTE) revealed a patent foramen ovale (PFO), which after percutaneous closure resulted in profound improvement in hypoxemia and clinical status. | Cardiac Catheterization, Electrocardiography, Foramen Ovale, Patent, Humans, Hypertension, Pulmonary, Hypoxia, Male, Middle Aged, Obesity, Morbid, Radiography, Interventional, Respiratory Insufficiency, Septal Occluder Device, Treatment Outcome | null |
22,705,151 | 2013-02-19 | 2025-01-03 | 1096-0023 | Cytokine | ssICAM-1, IL-21 and IL-23 in patients with tick borne encephalitis and neuroborreliosis. | Moniuszko Anna, Pancewicz Sławomir, Czupryna Piotr, Grygorczuk Sambor, Świerzbińska Renata, Kondrusik Maciej, Penza Paweł, Zajkowska Joanna | eng | null | Journal Article | ICAM1 protein, human, Interleukin-23, Interleukins, Intercellular Adhesion Molecule-1, Interleukin-21 | IM | 22705151, S1043-4666(12)00188-3, 10.1016/j.cyto.2012.05.007, PMC7128343, 18570589, 12098511, 12162874, 21947740, 17010588, 21085578, 22133343, 17581588, 16039904, 21629771, 19890092, 16200070, 19810097, 12402172, 16966222, 11080742, 19200759, 20626298, 16909787, 21338381, 17212614, 21529366, 18975343, 18325811, 21507218, 11086043, 18759008, 16027879 | There have been few reports on the role of Intercellular Adhesion Molecule 1 (ICAM-1), but not interleukin-21 (IL-21) and interleukin-23 (IL-23) in tick-borne encephalitis (TBE) and neuroborreliosis (NB). We postulate that these two interleukins may participate in the early phase of TBE and NB. The aim of the study was to measure serum and cerebrospinal fluid (CSF) concentration of ICAM-1, IL-21 and IL-23 in patients with TBE and NB before treatment and to assess their usefulness in the diagnosis and monitoring of inflammatory process in TBE and NB. | Adult, Aged, Aged, 80 and over, Case-Control Studies, Encephalitis, Tick-Borne, Female, Humans, Intercellular Adhesion Molecule-1, Interleukin-23, Interleukins, Lyme Neuroborreliosis, Male, Middle Aged, Platelet Count, Solubility, Interleukin-21 | null |
22,705,153 | 2013-02-01 | 2013-11-21 | 1096-0023 | Cytokine | Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV). | Fan Hebin, Zhu Zhenni, Wang Yang, Zhang Xiaoyong, Lu Yinping, Tao Yuanqing, Fan Wei, Wang Zhongdong, Wang Hu, Roggendorf Micheal, Lu Mengji, Wang Baoju, Yang Dongliang | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Interferon-alpha, Myxovirus Resistance Proteins, Receptor, Interferon alpha-beta, Interferon-gamma, GTP-Binding Proteins | IM | 22705153, S1043-4666(12)00209-8, 10.1016/j.cyto.2012.05.013 | Type I interferons (IFN-α/β) serve as the first line of defense against viral infection and share the same type I IFN receptor (IFNAR) complex, which is composed of IFNAR1 and -2. The Eastern woodchuck (Marmota monax) and Chinese woodchuck (Marmota himalayana) are suitable for studying hepatitis B virus (HBV) infection. Here, the complete or partial sequences of the IFNARs of both species were obtained and analyzed. Small interference RNAs targeting wIFNAR1 and -2 specifically down-regulated the expression of wIFNAR1 and -2 and the IFN-stimulated gene MxA in a woodchuck cell line, respectively. IFNAR2 was significantly up-regulated in primary woodchuck hepatocytes stimulated with IFN-α or -γ. The expression of woodchuck IFNAR1 and -2 was decreased in woodchucks chronically infected with woodchuck hepatitis virus (WHV). These results are essential for studying type I IFN-related innate immunity and therapy in hepadnaviral infection in the woodchuck model. | Amino Acid Sequence, Animals, Cell Line, Cloning, Molecular, GTP-Binding Proteins, Gene Expression, Hepatitis B, Hepatitis B Virus, Woodchuck, Hepatocytes, Host-Pathogen Interactions, Interferon-alpha, Interferon-gamma, Liver, Marmota, Molecular Sequence Data, Myxovirus Resistance Proteins, Phylogeny, RNA Interference, Receptor, Interferon alpha-beta, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Species Specificity | null |
22,705,154 | 2012-11-19 | 2017-11-16 | 0006-3002 | Biochimica et biophysica acta | ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP. | Lee Wing-Kee, Chakraborty Prabir K, Roussa Eleni, Wolff Natascha A, Thévenod Frank | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Best3 protein, rat, Bestrophins, Chloride Channels, Reactive Oxygen Species, Cadmium, Tunicamycin, Transcription Factor CHOP, Thapsigargin, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Calcium | IM | 22705154, S0167-4889(12)00158-9, 10.1016/j.bbamcr.2012.06.003 | Upon endoplasmic reticulum (ER) stress induction, cells endeavor to survive by engaging the adaptive stress response known as the unfolded protein response or by removing aggregated proteins via autophagy. Chronic ER stress culminates in apoptotic cell death, which involves induction of pro-apoptotic CHOP. Here, we show that bestrophin-3 (Best-3), a protein previously associated with Ca(2+)-activated Cl(-) channel activity, is upregulated by the ER stressors, thapsigargin (TG), tunicamycin (TUN) and the toxic metal Cd(2+). In cultured rat kidney proximal tubule cells, ER stress, CHOP and cell death were induced after 6h by Cd(2+) (25μM), TG (3μM) and TUN (6μM), were associated with increased cytosolic Ca(2+) and downstream formation of reactive oxygen species and attenuated by the Ca(2+) chelator BAPTA-AM (10μM), the antioxidant α-tocopherol (100μM), or overexpression of catalase (CAT). Immunofluorescence staining showed Best-3 expression in the plasma membrane, nuclei and intracellular compartments, though not in the ER, in cultured cells and rat kidney cortex sections. Best-3 mRNA was augmented by ER stress and signaled through increased Ca(2+), oxidative stress and ERK1/2 phosphorylation, because it was attenuated by α-tocopherol, CAT expression, BAPTA-AM, calmodulin kinase inhibitor calmidazolium (40μM), ERK1/2 inhibitor U0126 (10μM), and ERK1/2 RNAi. Knockdown of Best-3 resulted in decreased cell number consequentially of cell death, as determined by nuclear staining and PARP-1 cleavage. Furthermore, reduced ER stress-cell death by Best-3 overexpression is attributed to diminished CHOP. Since Best-3 overexpression did not affect upstream signaling pathways, we hypothesize that Best-3 possibly interferes with CHOP transcription. From our novel observations, we conclude that ERK1/2-dependent Best-3 activation regulates cell fate decisions during ER stress by suppressing CHOP induction and death. | Animals, Bestrophins, Cadmium, Calcium, Cell Death, Cell Lineage, Cell Membrane, Cell Nucleus, Chloride Channels, Cytoprotection, Endoplasmic Reticulum Stress, Enzyme Activation, Epithelial Cells, Kidney, Kinetics, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Models, Biological, Phosphorylation, Rats, Reactive Oxygen Species, Signal Transduction, Thapsigargin, Transcription Factor CHOP, Tunicamycin, Unfolded Protein Response, Up-Regulation | null |
22,705,155 | 2013-02-21 | 2022-04-08 | 0006-3002 | Biochimica et biophysica acta | In vitro cultured human Sertoli cells secrete high amounts of acetate that is stimulated by 17β-estradiol and suppressed by insulin deprivation. | Alves Marco G, Socorro Sílvia, Silva Joaquina, Barros Alberto, Sousa Mário, Cavaco José E, Oliveira Pedro F | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Acetates, Androgens, Insulin, Dihydrotestosterone, Estradiol, Acetyl-CoA Hydrolase | IM | 22705155, S0167-4889(12)00157-7, 10.1016/j.bbamcr.2012.06.002 | Several important functions for a successful spermatogenesis are dependent on Sertoli cells (SCs). Besides their unique characteristics as support cells, they produce essential cofactors and metabolites, and are responsible for nurturing the developing germ cells. The continuous production of lipids, phospholipids and proteins by germ cells must require high amounts of metabolic precursors. Thus, we hypothesized that hSCs could produce acetate in a hormonally-regulated manner. | Acetates, Acetyl-CoA Hydrolase, Androgens, Cells, Cultured, Dihydrotestosterone, Estradiol, Gene Expression, Humans, Insulin, Male, Sertoli Cells | null |
22,705,156 | 2012-10-12 | 2020-12-09 | 1873-3468 | FEBS letters | WNT-3a modulates platelet function by regulating small GTPase activity. | Steele Brian M, Harper Matthew T, Smolenski Albert P, Alkazemi Naheda, Poole Alastair W, Fitzgerald Desmond J, Maguire Patricia B | eng | RG/10/006/28299 (British Heart Foundation, United Kingdom) | Journal Article, Research Support, Non-U.S. Gov't | Adaptor Proteins, Signal Transducing, DAAM1 protein, human, Microfilament Proteins, Recombinant Proteins, Wnt3A Protein, Guanosine Triphosphate, RAP1B protein, human, Monomeric GTP-Binding Proteins, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein, rap GTP-Binding Proteins, rho GTP-Binding Proteins | IM | 22705156, S0014-5793(12)00446-2, 10.1016/j.febslet.2012.05.060 | Here we provide evidence that WNT-3a modulates platelet function by regulating the activity of four key GTPase proteins: Rap1, Cdc42, Rac1 and RhoA. We observe WNT-3a to differentially regulate small GTPase activity in platelets, promoting the GDP-bound form of Rap1b to inhibit integrin-α(IIb)β(3) adhesion, while concomitantly increasing Cdc42 and Rac1-GTP levels thereby disrupting normal platelet spreading. We demonstrate that Daam-1 interacts with Dishevelled upon platelet activation, which correlates with increased RhoA-GTP levels. Upon pre-treatment with WNT-3a, this complex disassociates, concurrent with a reduction in RhoA-GTP. Together these data implicate WNT-3a as a novel upstream regulator of small GTPase activity in platelets. | Adaptor Proteins, Signal Transducing, Blood Platelets, Densitometry, Extracellular Matrix, Gene Expression Regulation, Guanosine Triphosphate, Humans, Hydrolysis, Microfilament Proteins, Models, Biological, Monomeric GTP-Binding Proteins, Recombinant Proteins, Signal Transduction, Wnt3A Protein, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein, rap GTP-Binding Proteins, rho GTP-Binding Proteins | null |
22,705,152 | 2013-02-19 | 2024-06-10 | 1096-0023 | Cytokine | Effect of anticoagulants on multiplexed measurement of cytokine/chemokines in healthy subjects. | Biancotto Angélique, Feng Xingmin, Langweiler Marc, Young Neal S, McCoy J Philip | eng | Z99 HL999999 (Intramural NIH HHS, United States); ZIC HL005905 (Intramural NIH HHS, United States); ZIC HL005905-04 (Intramural NIH HHS, United States) | Journal Article | Anticoagulants, Chemokines, Reagent Kits, Diagnostic | IM | 22705152, S1043-4666(12)00215-3, 10.1016/j.cyto.2012.05.019, PMC3449030, NIHMS381099, 3871966, 12807715, 9339389, 22001645, 9558730, 16856875, 16527885, 21715603, 15914794, 15620530, 1381403, 16481199, 19058974, 19064561, 17337289, 19748508, 19394338, 16481197 | Cytokines are humoral regulatory molecules that act together in immunologic pathways. Monitoring cytokines and their variations within physiologic ranges is critical for biomarker discovery. Therefore, we evaluated the performance characteristics of 72 analytes measured by multiplex cytokine immunoassay, with an emphasis on the differences of analytes measured in serum compared to plasma, and, in plasma, on the impact of anticoagulants on the cytokine measurement. | Anticoagulants, Blood Coagulation, Chemokines, Health, Humans, Immunoassay, Reagent Kits, Diagnostic | null |
22,705,157 | 2013-08-23 | 2013-02-01 | 1879-1476 | Auris, nasus, larynx | 3D body segment oscillation and gait analysis for vestibular disorders. | Lang Juntian, Ishikawa Kazuo, Hatakeyama Kazutoshi, Wong Weng Hoe, Yin Min, Saito Takashi, Sibata Yutaka | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705157, S0385-8146(12)00015-6, 10.1016/j.anl.2011.11.007 | To investigate the patterns of gait and locomotion in three dimension space in patients with vestibular disorders. | Adult, Aged, Analysis of Variance, Case-Control Studies, Female, Gait, Humans, Locomotion, Male, Middle Aged, Movement, Proprioception, Vestibular Diseases, Young Adult | null |
22,705,158 | 2013-01-10 | 2022-12-07 | 1879-1271 | Clinical biomechanics (Bristol, Avon) | Comparison of four reconstruction methods after total sacrectomy: a finite element study. | Zhu Rui, Cheng Li-ming, Yu Yan, Zander Thomas, Chen Bo, Rohlmann Antonius | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705158, S0268-0033(12)00107-6, 10.1016/j.clinbiomech.2012.05.008 | After total sacrectomy, it is mandatory to reconstruct the continuity between the lumbar spine and the pelvis. Only few biomechanical analyses exist which compare different reconstructions. Therefore, the aim of this study was to compare the lumbo-pelvic motion and the relative risk of implant breakage for four different reconstructions after total sacrectomy. | Biomechanical Phenomena, Bone Screws, Elastic Modulus, Finite Element Analysis, Humans, Materials Testing, Motion, Orthopedic Procedures, Pelvis, Range of Motion, Articular, Plastic Surgery Procedures, Reproducibility of Results, Rotation, Sacrum, Spine | null |
22,705,159 | 2012-12-03 | 2014-05-29 | 1872-8383 | Trends in ecology & evolution | The impact of learning on sexual selection and speciation. | Verzijden Machteld N, ten Cate Carel, Servedio Maria R, Kozak Genevieve M, Boughman Jenny W, Svensson Erik I | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review | null | IM | 22705159, S0169-5347(12)00122-X, 10.1016/j.tree.2012.05.007 | Learning is widespread in nature, occurring in most animal taxa and in several different ecological contexts and, thus, might play a key role in evolutionary processes. Here, we review the accumulating empirical evidence for the involvement of learning in mate choice and the consequences for sexual selection and reproductive isolation. We distinguish two broad categories: learned mate preferences and learned traits under mate selection (such as bird song). We point out that the context of learning, namely how and when learning takes place, often makes a crucial difference to the predicted evolutionary outcome. Factors causing biases in learning and when one should expect the evolution of learning itself are also explored. | Animals, Biological Evolution, Genetic Speciation, Learning, Mating Preference, Animal, Phenotype, Sex Characteristics | null |
22,705,161 | 2012-10-17 | 2016-11-25 | 1532-2165 | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | An association between chronic obstructive pulmonary disease and abdominal aortic aneurysm beyond smoking: results from a case-control study. | Meijer C A, Kokje V B C, van Tongeren R B M, Hamming J F, van Bockel J H, Möller G M, Lindeman J H N | eng | null | Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | Doxycycline | IM | 22705161, S1078-5884(12)00340-1, 10.1016/j.ejvs.2012.05.016 | It is currently unclear whether the parallels between abdominal aortic aneurysms (AAAs) and chronic obstructive pulmonary disease (COPD) are explained by common risk factors alone, such as cigarette smoking, or by a predetermined cause. Given the persistent controversy with regard to the association between AAA and COPD, we studied this association in depth. | Aged, Aortic Aneurysm, Abdominal, Case-Control Studies, Chi-Square Distribution, Doxycycline, Female, Forced Expiratory Volume, Humans, Linear Models, Logistic Models, Lung, Male, Middle Aged, Multivariate Analysis, Netherlands, Odds Ratio, Prevalence, Pulmonary Disease, Chronic Obstructive, Risk Assessment, Risk Factors, Smoking, Spirometry, Surveys and Questionnaires, Ultrasonography, Vital Capacity | null |
22,705,160 | 2012-11-02 | 2022-03-11 | 1532-2165 | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | AAA with a challenging neck: early outcomes using the Endurant stent-graft system. | Setacci F, Sirignano P, de Donato G, Chisci E, Iacoponi F, Galzerano G, Palasciano G, Cappelli A, Setacci C | eng | null | Journal Article | null | IM | 22705160, S1078-5884(12)00320-6, 10.1016/j.ejvs.2012.04.031 | The efficacy and safety of endovascular aneurysm repair is disputable in aneurysms with a short, angulated, wide, conical, or thrombus-lined neck making a reliable seal difficult to achieve. The influence of a challenging neck on early results using the Endurant stent-graft system in high risk patients was investigated. | Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, Aortography, Blood Vessel Prosthesis, Blood Vessel Prosthesis Implantation, Chi-Square Distribution, Elective Surgical Procedures, Endovascular Procedures, Female, Humans, Italy, Male, Prosthesis Design, Retrospective Studies, Risk Assessment, Risk Factors, Stents, Tomography, X-Ray Computed, Treatment Outcome | null |
22,705,162 | 2012-10-17 | 2022-12-07 | 1532-2165 | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | Epidemiology of peripheral artery disease in elder general population of two cities of Central Africa: Bangui and Brazzaville. | Guerchet M, Aboyans V, Mbelesso P, Mouanga A M, Salazar J, Bandzouzi B, Tabo A, Clément J P, Preux P M, Lacroix P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705162, S1078-5884(12)00343-7, 10.1016/j.ejvs.2012.05.019 | Peripheral artery disease (PAD) is a common condition in Western countries, mostly in the elderly. Little is known about the epidemiology of PAD in Africa. We sought to determine the prevalence of this condition in the elderly in two community-dwelling cohorts in Central Africa. | Age Factors, Aged, Aged, 80 and over, Ankle Brachial Index, Black People, Central African Republic, Congo, Cross-Sectional Studies, Female, Humans, Logistic Models, Male, Multivariate Analysis, Odds Ratio, Peripheral Arterial Disease, Prevalence, Prospective Studies, Risk Assessment, Risk Factors, Urban Health | null |
22,705,163 | 2012-10-17 | 2022-03-30 | 1532-2165 | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | A systematic review and meta-analysis of randomised controlled trials comparing endovenous ablation and surgical intervention in patients with varicose vein. | Siribumrungwong B, Noorit P, Wilasrusmee C, Attia J, Thakkinstian A | eng | null | Journal Article, Meta-Analysis, Review, Systematic Review | null | IM | 22705163, S1078-5884(12)00341-3, 10.1016/j.ejvs.2012.05.017 | A systematic review and meta-analysis was conducted to compare clinical outcomes between endovenous laser ablation (EVLA), radiofrequency ablation (RFA), ultrasound-guided foam sclerotherapy (UGFS) and surgery. | Ablation Techniques, Adult, Catheter Ablation, Endovascular Procedures, Evidence-Based Medicine, Female, Humans, Laser Therapy, Male, Middle Aged, Odds Ratio, Postoperative Complications, Randomized Controlled Trials as Topic, Recurrence, Risk Assessment, Risk Factors, Sclerotherapy, Time Factors, Treatment Outcome, Varicose Veins, Vascular Surgical Procedures | null |
22,705,167 | 2013-01-17 | 2012-08-21 | 1872-7697 | International journal of psychophysiology : official journal of the International Organization of Psychophysiology | Short-term cardiovascular responses to changing task demands. | Stuiver A, de Waard D, Brookhuis K A, Dijksterhuis C, Lewis-Evans B, Mulder L J M | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705167, S0167-8760(12)00168-7, 10.1016/j.ijpsycho.2012.06.003 | When measuring operator states the predictive power of cardiovascular and respiratory measures in relation to mental workload has been questioned. One of the main questions is to what extent do cardiovascular measures actually reflect mental workload. This question arises because good measures of mental workload should be sensitive to changes in mental effort alone and not to other influences or at least the changes associated with mental workload should be easy to isolate. In the case of cardiovascular measures, the physiological change brought on by the baroreflex is a compensatory control effect that can potentially overshadow changes in physiology due to mental effort and therefore reduce the usefulness of cardiovascular measures. However, this does not need to be the case. Despite the effects caused by the baroreflex differences in heart rate, heart rate variability and other cardiovascular measures associated with task related effort can still be found using short-term response patterns. The short-segment analysis approach described in this paper is based on a time-frequency method in which the spectral power of the cardiovascular measures in specified spectral bands is computed from small time segments, i.e. 30 s. To demonstrate the effectiveness of this technique two studies which made use of a simulation of an ambulance dispatcher's task are described, both with easy and difficult task conditions. A short-lasting increase in task demand was found to be reflected in short-lasting increases in heart rate and blood pressure in combination with corresponding decreases in heart rate variability and blood pressure variability. These effects were larger in easy task conditions than in hard conditions, likely due to a higher overall effort-level during the hard task conditions. However, the developed measures are still very sensitive to mental effort and if this brief segmentation approach is used cardiovascular measures show promise as good candidates for reflecting mental effort during the assessment of operator state. | Adult, Ambulances, Baroreflex, Blood Pressure, Computer Simulation, Electrocardiography, Female, Heart Rate, Humans, Male, Spectrum Analysis, Workload, Young Adult | null |
22,705,164 | 2013-01-10 | 2012-08-13 | 1873-2054 | Health & place | Positive effect of a targeted intervention to improve access and availability of fruit and vegetables in an area of deprivation. | Jennings Amy, Cassidy Aedín, Winters Tim, Barnes Sarah, Lipp Alistair, Holland Richard, Welch Ailsa | eng | null | Journal Article | null | null | 22705164, S1353-8292(12)00077-9, 10.1016/j.healthplace.2012.05.001 | Increasing fruit and vegetable intake has the potential to prevent chronic disease risk but substantial inequalities in intake exist between advantaged and disadvantaged communities. Access and availability of fruit and vegetables have been shown to be important determinants of intake. The current study aimed to evaluate the effectiveness of a Mobile Food Store intervention to improve access to fruit and vegetables by making cost-price produce available to targeted communities. Postcode mapping identified communities with low fruit and vegetable intake and high chronic disease risk. The Mobile Food Store travelled to these communities each week. Evaluation of self-reported fruit and vegetable intake was collected by validated questionnaire for 255 users (62% response rate). Store use resulted in a significant increase in intake (1.2 portions per day, 95%CI 0.83-1.48; p<0.001) which was greater than all but one previous intervention in the UK. The targeted model of improving access to fruit and vegetables was effective in increasing intake; however future controlled trials are required to objectively examine potential effects on fruit and vegetable intake and health outcomes. | Adolescent, Adult, Aged, Female, Fruit, Health Promotion, Humans, Male, Middle Aged, Poverty Areas, Self Report, Vegetables, Young Adult | null |
22,705,166 | 2012-11-28 | 2012-07-31 | 0968-0004 | Trends in biochemical sciences | Linear motifs: lost in (pre)translation. | Weatheritt Robert J, Gibson Toby J | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | MicroRNAs, Protein Isoforms, RNA, Messenger | IM | 22705166, S0968-0004(12)00069-2, 10.1016/j.tibs.2012.05.001 | Pretranslational modification by alternative splicing, alternative promoter usage and RNA editing enables the production of multiple protein isoforms from a single gene. A large quantity of data now supports the notion that short linear motifs (SLiMs), which are protein interaction modules enriched within intrinsically disordered regions, are key for the functional diversification of these isoforms. The inclusion or removal of these SLiMs can switch the subcellular localisation of an isoform, promote cooperative associations, refine the affinity of an interaction, coordinate phase transitions within the cell, and even create isoforms of opposing function. This article discusses the novel functionality enabled by the addition or removal of SLiM-containing exons by pretranslational modifications, such as alternative splicing and alternative promoter usage, and how these alterations enable the creation and modulation of complex regulatory and signalling pathways. | Alternative Splicing, Amino Acid Motifs, Animals, Apoptosis, Exons, Humans, MicroRNAs, Promoter Regions, Genetic, Protein Biosynthesis, Protein Interaction Mapping, Protein Isoforms, Protein Processing, Post-Translational, Protein Structure, Tertiary, RNA Editing, RNA, Messenger, Signal Transduction | null |
22,705,168 | 2013-01-17 | 2014-03-25 | 1872-7697 | International journal of psychophysiology : official journal of the International Organization of Psychophysiology | Brain potentials in outcome evaluation: when social comparison takes effect. | Wu Yan, Zhang Dexuan, Elieson Bill, Zhou Xiaolin | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705168, S0167-8760(12)00169-9, 10.1016/j.ijpsycho.2012.06.004 | Social comparison, in which people evaluate their opinions and abilities by comparing them with the opinions and abilities of others, is a central feature of human social life. Previous work has highlighted the importance of social comparison in reward processing. However, the time-course of the social comparison effect in outcome evaluation remains largely unknown. The purpose of this study was to explore to what extent brain activity is modulated by social comparison between an individual and their anonymous partner. Event-related potentials (ERPs) were measured while the participants viewed their own and their partner's gain and loss outcomes based on their performance in a dot estimation task. Analysis of ERPs revealed that the feedback-related negativity (FRN) amplitude differences between gains and losses were not modulated by social comparison. In contrast, the P300 was larger for gains and showed an effect of social comparison independent of feedback valence. A late component, the late positive potential (LPP), was also modulated by social comparison, but it was insensitive to feedback valence. The data suggest that social comparison modulates outcome evaluation at several points in the information processing stream. Social comparison has no effect on the early coarse evaluation stage, but modulates the late cognitive/affective appraisal and re-appraisal processes. These findings provide neurophysiological evidence for the importance of social comparisons in outcome evaluations by the human brain. | Analysis of Variance, Brain, Brain Mapping, Electroencephalography, Evoked Potentials, Feedback, Psychological, Female, Gambling, Humans, Interpersonal Relations, Male, Reaction Time, Reward, Students, Universities | null |
22,705,169 | 2013-01-17 | 2012-08-21 | 1872-7697 | International journal of psychophysiology : official journal of the International Organization of Psychophysiology | Why do you smile at me while I'm in pain? --Pain selectively modulates voluntary facial muscle responses to happy faces. | Gerdes Antje B M, Wieser Matthias J, Alpers Georg W, Strack Fritz, Pauli Paul | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705169, S0167-8760(12)00167-5, 10.1016/j.ijpsycho.2012.06.002 | It has been well documented that emotional stimuli modulate pain perception, but little is known about the reverse influence pain may have on emotion processing. According to the motivational priming theory, pain should facilitate the processing of unpleasant and hamper the processing of pleasant affective stimuli. To this end, we investigated the influence of tonic pain on the processing of happy and angry faces in 30 healthy participants. As a measure of affect processing, the interference of picture content on participants' voluntary reactions to the pictures either with a compatible or an incompatible facial muscle (M. zygomaticus major ["smile"] or M. corrugator supercilii ["frown"]) was recorded by electromyogram (EMG). Additionally, participants rated valence and arousal of each picture. During both tasks, the participants received either painful or non-painful pressure stimulation. Pain stimulation was generally associated with slower compatible and incompatible muscle responses (M. zygomaticus and M. corrugator) and fewer erroneous incompatible (M. corrugator) responses to happy faces. However, pain did not affect muscle responses to angry faces and explicit valence and arousal ratings. Thus, pain seems to selectively influence the responses to happy faces, which may result from a slowed processing of incongruent information (happy/pain). That happy faces are processed differently during pain may bear important implications for social interactions during acute and possibly even chronic pain states. | Adult, Analysis of Variance, Electromyography, Facial Expression, Facial Muscles, Female, Happiness, Humans, Male, Pain, Pain Measurement, Photic Stimulation, Reaction Time, Smiling, Young Adult | null |
22,705,171 | 2012-11-07 | 2017-11-16 | 1096-0309 | Analytical biochemistry | Performance of fluorescent europium(III) nanoparticles and colloidal gold reporters in lateral flow bioaffinity assay. | Juntunen Etvi, Myyryläinen Tiina, Salminen Teppo, Soukka Tero, Pettersson Kim | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Gold Colloid, Serum Albumin, Bovine, Europium, Prostate-Specific Antigen | IM | 22705171, S0003-2697(12)00309-0, 10.1016/j.ab.2012.06.005 | Lateral flow (LF) immunoassays (i.e., immunochromatographic assays) have traditionally been applied to analytes that do not require very high analytical sensitivity or quantitative results. The selection of potential analytes is often limited by the performance characteristics of the assay technology. Analytes with more demanding sensitivity requirements call for reporter systems enabling high analytical sensitivity. In this study, we systematically compared the performance of fluorescent europium(III) [Eu(III)] chelate dyed polystyrene nanoparticles and colloidal gold particles in lateral flow assays. The effect of time-resolved measurement mode was also studied. Because binder molecules used in immunoassays might not behave similarly when conjugated to different reporter particles, two model assays were constructed to provide reliable technical comparison of the two reporter systems. The comparative experiment demonstrated that the fluorescent nanoparticles yielded 7- and 300-fold better sensitivity compared with colloidal gold in the two test systems, respectively. Although the two reporter particles may induce variable effects using individual binders, overall the high specific activity of Eu(III) nanoparticles has superior potential over colloidal gold particles for the development of robust high-sensitivity bioaffinity assays. | Animals, Biotinylation, Cattle, Europium, Fluorescence, Gold Colloid, Humans, Immunoassay, Metal Nanoparticles, Prostate-Specific Antigen, Rheology, Serum Albumin, Bovine, Signal-To-Noise Ratio, Time Factors | null |
22,705,170 | 2012-10-19 | 2015-11-19 | 1873-376X | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences | Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples. | Desoubries Charlotte, Chapuis-Hugon Florence, Bossée Anne, Pichon Valérie | eng | null | Journal Article | Chemical Warfare Agents, Organophosphorus Compounds, Polypropylenes, Water, Sodium Chloride, 1-Octanol | IM | 22705170, S1570-0232(12)00310-8, 10.1016/j.jchromb.2012.05.029 | Degradation products of chemical warfare agents are considered as important environmental and biological markers of chemical attacks. Alkyl methylphosphonic acids (AMPAs), resulting from the fast hydrolysis of nerve agents, such as sarin and soman, and the methylphosphonic acid (MPA), final degradation product of AMPAs, were determined from complex matrices by using an emergent and miniaturized extraction technique, the hollow fiber liquid-phase microextraction (HF-LPME), before their analysis by liquid chromatography coupled to mass spectrometry (LC-MS). After studying different conditions of separation in the reversed phase LC-MS analysis, the sample treatment method was set up. The three-phase HF-LPME was carried out by using a porous polypropylene (PP) hollow fiber impregnated with 1-octanol that separates the donor and acceptor aqueous media. Various extraction parameters were evaluated such as the volume of the sample, the effect of the pH and the salt addition to the sample, the pH of the acceptor phase, the extraction temperature, the stirring speed of the sample, the immersion time in the organic solvent and the time of extraction. The optimum conditions were applied to the determination of MPA and five AMPAs in real samples, such as surface waters and urine. Compounds were extracted from a 3 mL acidified sample into only 6 μL of alkaline water without any other pretreatment of the complex matrices. Enrichment factors (EFs) higher than 170 were obtained for three less polar AMPAs. Limits of quantification (LOQs) in the 0.013-5.3 ng mL(-1) range were obtained after microextraction of AMPAs from river water and in the range of 0.056-4.8 ng mL(-1) from urine samples with RSD values between 1 and 9%. | 1-Octanol, Chemical Warfare Agents, Chromatography, Liquid, Humans, Hydrogen-Ion Concentration, Linear Models, Liquid-Liquid Extraction, Mass Spectrometry, Organophosphorus Compounds, Polypropylenes, Reproducibility of Results, Rivers, Sensitivity and Specificity, Sodium Chloride, Temperature, Water | null |
22,705,172 | 2012-11-07 | 2013-11-21 | 1096-0309 | Analytical biochemistry | Development of a sandwich format, amperometric screen-printed uric acid biosensor for urine analysis. | Kanyong P, Pemberton R M, Jackson S K, Hart J P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Buffers, Uric Acid | IM | 22705172, S0003-2697(12)00310-7, 10.1016/j.ab.2012.05.027 | A screen-printed carbon electrode (SPCE) incorporating the electrocatalyst cobalt phthalocyanine (CoPC), fabricated using a water-based ink formulation, has been investigated as the base transducer for a uric acid biosensor. A sandwich biosensor was fabricated by first depositing cellulose acetate (CA) onto this transducer (CoPC-SPCE), followed by uricase (UOX) and finally a polycarbonate (PC) membrane; this device is designated PC-UOX-CA-CoPC-SPCE. This biosensor was used in conjunction with chronoamperometry to optimize the conditions for the analysis of urine: temperature, 35°C; buffer, pH 9.2; ionic strength, 50 mM; uricase, 0.6 U; incubation time, 180 s. The proposed biosensor was applied to urine from a healthy subject. The precision determined on unspiked urine (n=6) was 5.82%. Urine was fortified with 0.225 mM UA, and the resulting precision and recovery were 4.21 and 97.3%, respectively. The linear working range of the biosensor was found to be 0.015 to 0.25 mM (the former represents the detection limit), and the sensitivity was calculated to be 2.10 μA/mM. | Biosensing Techniques, Buffers, Calibration, Electrochemistry, Humans, Uric Acid, Urinalysis | null |
22,705,165 | 2012-12-11 | 2012-10-05 | 1528-3968 | Nursing outlook | Media images and screen representations of nurses. | Heilemann Marysue V | eng | null | Editorial, Introductory Journal Article | null | IM | 22705165, S0029-6554(12)00080-2, 10.1016/j.outlook.2012.04.003 | null | Humans, Mass Media, Nurse's Role, Stereotyping | null |
22,705,174 | 2013-04-12 | 2012-11-02 | 1873-2518 | Vaccine | Projected health impact and cost-effectiveness of rotavirus vaccination among children <5 years of age in China. | Liu Na, Yen Catherine, Fang Zhao-yin, Tate Jacqueline E, Jiang Baoming, Parashar Umesh D, Zeng Guang, Duan Zhao-jun | eng | null | Journal Article | Rotavirus Vaccines | IM | 22705174, S0264-410X(12)00836-5, 10.1016/j.vaccine.2012.05.084 | Two rotavirus vaccines have been licensed globally since 2006. In China, only a lamb rotavirus vaccine is licensed and several new rotavirus vaccines are in development. Data regarding the projected health impact and cost-effectiveness of vaccination of children in China against rotavirus will assist policy makers in developing recommendations for vaccination. | Child, Preschool, China, Cost-Benefit Analysis, Female, Health Policy, Humans, Infant, Male, Models, Statistical, Rotavirus Infections, Rotavirus Vaccines, Vaccination | null |
22,705,173 | 2013-01-10 | 2016-11-25 | 1873-2518 | Vaccine | Immunization with the conjugate vaccine Vi-CRM₁₉₇ against Salmonella typhi induces Vi-specific mucosal and systemic immune responses in mice. | Fiorino Fabio, Ciabattini Annalisa, Rondini Simona, Pozzi Gianni, Martin Laura B, Medaglini Donata | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antibodies, Bacterial, Bacterial Proteins, Immunoglobulin A, Immunoglobulin G, Polysaccharides, Bacterial, Typhoid-Paratyphoid Vaccines, Vaccines, Conjugate, CRM197 (non-toxic variant of diphtheria toxin) | IM | 22705173, S0264-410X(12)00833-X, 10.1016/j.vaccine.2012.05.081 | Typhoid fever is a public health problem, especially among young children in developing countries. To address this need, a glycoconjugate vaccine Vi-CRM₁₉₇, composed of the polysaccharide antigen Vi covalently conjugated to the non-toxic mutant of diphtheria toxin CRM₁₉₇, is under development. Here, we assessed the antibody and cellular responses, both local and systemic, following subcutaneous injection of Vi-CRM₁₉₇. The glycoconjugate elicited Vi-specific serum IgG titers significantly higher than unconjugated Vi, with prevalence of IgG1 that persisted for at least 60 days after immunization. Vi-specific IgG, but not IgA, were present in intestinal washes. Lymphocytes proliferation after restimulation with Vi-CRM₁₉₇ was observed in spleen and mesenteric lymph nodes. These data confirm the immunogenicity of Vi-CRM₁₉₇ and demonstrate that the vaccine-specific antibody and cellular immune responses are present also in the intestinal tract, thus strengthening the suitability of Vi-CRM₁₉₇ as a promising candidate vaccine against Salmonella Typhi. | Animals, Antibodies, Bacterial, Antibody Formation, Bacterial Proteins, Cell Proliferation, Immunity, Cellular, Immunity, Mucosal, Immunoglobulin A, Immunoglobulin G, Lymph Nodes, Mice, Mice, Inbred BALB C, Polysaccharides, Bacterial, Salmonella typhi, Spleen, T-Lymphocytes, Typhoid Fever, Typhoid-Paratyphoid Vaccines, Vaccines, Conjugate | null |
22,705,176 | 2014-06-03 | 2024-01-09 | 1879-0291 | Marine environmental research | Salinity critical threshold values for photosynthesis of two cosmopolitan seaweed species: providing baselines for potential shifts on seaweed assemblages. | Scherner Fernando, Ventura Robson, Barufi José Bonomi, Horta Paulo Antunes | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705176, S0141-1136(12)00106-7, 10.1016/j.marenvres.2012.05.007 | Climate change has increased precipitation in several South American regions leading to higher freshwater inputs into marine systems with potential to cause salinity declines along the coast. The current salinity profile on the southern coast of Brazil was surveyed during four years providing a baseline of the current salinity pattern in the region. Additionally, the effects of salinity decreases on the photosynthesis of the seaweeds Ulva lactuca and Sargassum stenophyllum were investigated in laboratory. Seaweeds were cultured at salinities 5, 15 and 34 and at the mean winter and summer temperatures. Photosynthetic performance was measured following 24 and 96 h from the beginning of experiment. U. lactuca remained practically unaltered by low salinities while S. stenophyllum presented declines of important photosynthetic parameters. This is due to the different regulation abilities of energy distribution at the PSII of the two species. These differences have potential to lead to seaweed community shifts. | Biodiversity, Climate Change, Data Collection, Fluorometry, Photosynthesis, Salinity, Sargassum, Seasons, Temperature, Ulva | Climate change, Freshwater, Photosynthetic performance, Rainfall, Salinity, Sargassum stenophyllum, South America, Ulva lactuca |
22,705,175 | 2012-11-29 | 2022-03-30 | 1873-2518 | Vaccine | The structure of HBsAg particles is not modified upon their adsorption on aluminium hydroxide gel. | Greiner Vanille J, Ronzon Frédéric, Larquet Eric, Desbat Bernard, Estèves Catherine, Bonvin Julie, Gréco Frédéric, Manin Catherine, Klymchenko Andrey S, Mély Yves | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't | Flavonoids, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Lipids, Vaccines, Virus-Like Particle, Aluminum Hydroxide, 3-hydroxyflavone | IM | 22705175, S0264-410X(12)00834-1, 10.1016/j.vaccine.2012.05.082 | Current Hepatitis B vaccines are based on recombinant Hepatitis B surface antigen (HBsAg) virus-like particles adsorbed on aluminium (Al) gel. These particles exhibit a lipoprotein-like structure with about 70 protein S molecules in association with various types of lipids. To determine whether the adsorption on Al gel affects HBsAg structure, we investigated the effect of adsorption and mild desorption processes on the protein and lipid parts of the particles, using various techniques. Electron microscopy showed that the size and morphology of native and desorbed HBsAg particles were comparable. Moreover, infrared and Raman spectroscopy revealed that the secondary structure of the S proteins was not affected by the adsorption/desorption process. Affinity measurements with Surface Plasmon Resonance showed no difference between native and desorbed HBsAg for HBsAg-specific RF-1 monoclonal antibody. Steady-state and time-resolved fluorescence data of the intrinsic fluorescence of the S proteins further indicated that the adsorption/desorption of HBsAg particles on Al gel did not modify the environment of the most emitting Trp residues, confirming that the conformation of the S proteins remains intact. Moreover, using environment-sensitive 3-hydroxyflavone probes, no significant changes of the lipid core and lipid membrane surface of the HBsAg particles were observed during the adsorption/desorption process. Finally, the ratio between lipids and proteins in the particles was found to be similar before and after the adsorption/desorption process. Taken together, our data show that adsorption on Al gel does not affect the structure of the HBsAg particles. | Adsorption, Aluminum Hydroxide, Circular Dichroism, Flavonoids, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Lipids, Microscopy, Electron, Protein Structure, Secondary, Spectrometry, Fluorescence, Spectrophotometry, Infrared, Surface Plasmon Resonance, Vaccines, Virus-Like Particle | null |
22,705,179 | 2012-11-28 | 2012-07-31 | 1095-8541 | Journal of theoretical biology | Cultural evolution of a belief controlling human mate choice: dynamic modeling of the hinoeuma superstition in Japan. | Tanaka Cinthia Marie, Iwasa Yoh | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705179, S0022-5193(12)00278-0, 10.1016/j.jtbi.2012.06.001 | We develop a simple cultural dynamics model to dicuss the spread of the hinoeuma superstition in Japan. A large drop in the number of newborn babies observed in 1966 was attributed mainly to parents' avoiding having a child born in a hinoeuma year. Presumably, Japanese parents were afraid that a daughter born in 1966 (a hinoeuma year) might later have difficulty finding a mate. We construct mathematical models to examine whether the hinoeuma superstition would likely become extinct or be stably maintained in the population. We classify members of a population according to whether they believed the hinoeuma superstition (believer or nonbeliever), their gender (male or female), and their year of birth (born in a hinoeuma year or not). We compare several cases that differ according to (1) whether the belief in the superstition was transmitted to children by matrilineal, patrilineal, or Mendelian inheritance; (2) which parent controlled the timing of pregnancy and childbirth (maternal or paternal birth control); and (3) the probability of birth control failure. Our results show that the hinoeuma superstition is likely to spread if the mother has a strong influence on birth control and on the belief of their children. In contrast, if birth control is paternal and the belief is passed down from father to child, the hinoeuma superstition is likely to become extinct. In between these extremes, whether the superstition becomes extinct or fixed in the population depends on the initial frequency of believers in the population. | Choice Behavior, Contraception, Cultural Evolution, Culture, Fathers, Female, Humans, Inheritance Patterns, Japan, Male, Models, Biological, Mothers, Sexual Partners, Superstitions | null |
22,705,180 | 2013-12-03 | 2013-07-15 | 1873-5347 | Social science & medicine (1982) | Is physical activity in natural environments better for mental health than physical activity in other environments? | Mitchell Richard | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705180, S0277-9536(12)00356-5, 10.1016/j.socscimed.2012.04.012 | Experimental evidence suggests that there may be synergy between the psychological benefits of physical activity, and the restorative effects of contact with a natural environment; physical activity in a natural environment might produce greater mental health benefits than physical activity elsewhere. However, such experiments are typically short-term and, by definition, artificially control the participant types, physical activity and contact with nature. This observational study asked whether such effects can be detected in everyday settings at a population level. It used data from the Scottish Health Survey 2008, describing all environments in which respondents were physically active. Associations were sought between use of each environment, and then use of environments grouped as natural or non-natural, and the risk of poor mental health (measured by the General Health Questionnaire (GHQ)) and level of wellbeing (measured by the Warwick Edinburgh Mental health and Wellbeing Score (WEMWBS). Results showed an independent association between regular use of natural environments and a lower risk of poor mental health, but not for activity in other types of environment. For example, the odds of poor mental health (GHQ ≥ 4) among those regularly using woods or forests for physical activity were 0.557 (95% CI 0.323-0.962), compared to non-users. However, regular use of natural environments was not clearly associated with greater wellbeing, whilst regular use of non-natural environments was. The study concludes that physical activity in natural environments is associated with a reduction in the risk of poor mental health to a greater extent than physical activity in other environments, but also that activity in different types of environment may promote different kinds of positive psychological response. Access to natural environments for physical activity should be protected and promoted as a contribution to protecting and improving population mental health. | Environment, Environment Design, Health Surveys, Humans, Mental Health, Motor Activity, Scotland | Environment, Green space, Mental health, Physical activity, Scotland, UK, Wellbeing |
22,705,177 | 2013-05-22 | 2024-05-04 | 1872-9738 | Neurotoxicology and teratology | Neurobehavioral deficits at age 7 years associated with prenatal exposure to toxicants from maternal seafood diet. | Grandjean Philippe, Weihe Pal, Nielsen Flemming, Heinzow Birger, Debes Frodi, Budtz-Jørgensen Esben | eng | R01 ES009797 (NIEHS NIH HHS, United States); U01 ES009797 (NIEHS NIH HHS, United States); ES09797 (NIEHS NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural | Environmental Pollutants | IM | 22705177, S0892-0362(12)00120-1, 10.1016/j.ntt.2012.06.001, PMC3407364, NIHMS391348, 17067778, 8866532, 22146557, 16455139, 16169054, 8757236, 10430235, 3685941, 19165381, 21166449, 20890403, 15660622, 11485834, 20176542, 9392777, 17174709, 10802490, 10440491, 19012089, 17431478, 10428598, 21357386, 18853821, 21719373, 17692354, 20419070, 12513702, 18155821, 20868742, 1596101, 21679971 | To determine the possible neurotoxic impact of prenatal exposure to polychlorinated biphenyls (PCBs), we analyzed banked cord blood from a Faroese birth cohort for PCBs. The subjects were born in 1986-1987, and 917 cohort members had completed a series of neuropsychological tests at age 7 years. Major PCB congeners (118, 138, 153, and 180), the calculated total PCB concentration, and the PCB exposure estimated in a structural equation model showed weak associations with test deficits, with statistically significant negative associations only with the Boston Naming test. Likewise, neither hexachlorobenzene nor p,p'-dichlorodiphenyldichloroethylene showed clear links to neurobehavioral deficits. Thus, these associations were much weaker than those associated with the cord-blood mercury concentration, and adjustment for mercury substantially attenuated the regression coefficients for PCB exposure. When the outcomes were joined into motor and verbally mediated functions in a structural equation model, the PCB effects remained weak and virtually disappeared after adjustment for methylmercury exposure, while mercury remained statistically significant. Thus, in the presence of elevated methylmercury exposure, PCB neurotoxicity may be difficult to detect, and PCB exposure does not explain the methylmercury neurotoxicity previously reported in this cohort. | Adult, Child, Child Behavior Disorders, Cognition Disorders, Cohort Studies, Environmental Pollutants, Female, Food, Formulated, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Seafood | null |
22,705,181 | 2013-04-08 | 2022-06-30 | 1873-5347 | Social science & medicine (1982) | Sleeping, dreaming, and health in rural Indonesia and the urban U.S.: a cultural and experiential approach. | Hollan Douglas | eng | null | Journal Article | null | IM | 22705181, S0277-9536(12)00418-2, 10.1016/j.socscimed.2012.05.006 | Sleeping, dreaming, and health or well-being are all closely related phenomena from an experiential and cultural point of view, and yet all three are often studied in isolation from one another. In this paper, I use an ethnographic and clinical lens to compare and contrast patterns of sleeping and dreaming and their relationship to health in a rural Indonesian society and among urban middle class people in the US. I demonstrate how culturally shaped patterns of sleeping and dreaming become linked through social practice and the implication of these practices for health and well being. I underscore, in particular, the seamless connection between waking and non-waking life, how daytime activities affect patterns of sleeping and dreaming, but also how the emotional and behavioral residues of the night affect daytime life and experience. Data for the Indonesia case were collected during extended fieldwork in 1981-1983, while the U.S. data come from my ongoing part-time private practice of psychotherapy and psychoanalysis. | Cross-Cultural Comparison, Dreams, Humans, Indonesia, Rural Health, Sleep, United States, Urban Health | null |
22,705,182 | 2012-11-08 | 2012-07-09 | 1873-5347 | Social science & medicine (1982) | From cottage industry to a dominant mode of primary care: stages in the diffusion of a health care innovation (retail clinics). | McKinlay John B, Marceau Lisa D | eng | null | Journal Article | null | IM | 22705182, S0277-9536(12)00411-X, 10.1016/j.socscimed.2012.04.039 | Primary health care is essential to population health and there is increasing need for it, especially with an aging population with multiple comorbidities. Primary health care in the U.S. is widely considered in an ever-deepening crisis. This paper presents a detailed case study of the recent rise of a "disruptive innovation" - retail clinics - which have the potential to transform the face of primary health care in the US. We describe six stages in the diffusion of retail clinics, from cottage industry to a dominant mode for the delivery of primary health care, and consider sociopolitical influences that facilitate and impede their emerging potential. Retail clinics may provide a strategic opportunity to re-engineer the primary health care system, although they may also produce worrisome unanticipated consequences. Discussion concerning the potential threats and opportunities posed by retail clinics occurs in the absence of sound evidence concerning their comparative effectiveness and quality-of-care. This case study identifies the sociopolitical influences and processes that determine whether health care innovations rise or fall, and highlights critically important points along the pathway to health system change. | Commerce, Delivery of Health Care, Diffusion of Innovation, Humans, Primary Health Care, United States | null |
22,705,178 | 2012-12-17 | 2024-06-10 | 1528-0012 | Gastroenterology | Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver. | Ibrahim Junaid, Nguyen Andrew H, Rehman Adeel, Ochi Atsuo, Jamal Mohsin, Graffeo Christopher S, Henning Justin R, Zambirinis Constantinos P, Fallon Nina C, Barilla Rocky, Badar Sana, Mitchell Aaron, Rao Raghavendra S, Acehan Devrim, Frey Alan B, Miller George | eng | CA108573 (NCI NIH HHS, United States); R21 CA155649 (NCI NIH HHS, United States); CA155649 (NCI NIH HHS, United States); K08 DK085278 (NIDDK NIH HHS, United States); DK085278 (NIDDK NIH HHS, United States); R01 CA108573 (NCI NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't | Antigens, CD, Antigens, CD1d, B7-1 Antigen, B7-2 Antigen, CD11b Antigen, CD40 Antigens, Lipids, Tumor Necrosis Factor-alpha, Intercellular Adhesion Molecule-1, Leukocyte Common Antigens | IM | 22705178, S0016-5085(12)00819-0, 10.1053/j.gastro.2012.06.003, PMC3459067, NIHMS387347, 15486293, 16174093, 20080065, 20089704, 18835746, 20972472, 18669892, 12234994, 19424018, 12884867, 11912201, 19217323, 19575456, 20622859, 11415995, 20833718, 16163670, 18551047, 19201843, 18458347, 15690074, 14707074, 18213574, 19461119, 9220970, 21697460, 7992967, 19855130, 18789731, 16203857, 20042467 | Immune cells of the liver must be able to recognize and react to pathogens yet remain tolerant to food molecules and other nonpathogens. Dendritic cells (DCs) are believed to contribute to hepatic tolerance. Lipids have been implicated in dysfunction of DCs in cancer. Therefore, we investigated whether high lipid content in liver DCs affects induction of tolerance. | Adipogenesis, Animals, Antigens, CD, Antigens, CD1d, Apoptosis, B7-1 Antigen, B7-2 Antigen, CD11b Antigen, CD40 Antigens, Cells, Cultured, Dendritic Cells, Humans, Immune Tolerance, Intercellular Adhesion Molecule-1, Killer Cells, Natural, Leukocyte Common Antigens, Lipid Metabolism, Lipids, Liver, Lymphocyte Activation, Mice, Natural Killer T-Cells, Phenotype, T-Lymphocytes, T-Lymphocytes, Regulatory, Tumor Necrosis Factor-alpha | null |
22,705,184 | 2012-10-23 | 2016-11-25 | 1365-229X | Clinical radiology | MRI protocols for imaging paediatric brain tumours. | Craig E, Connolly D J A, Griffiths P D, Raghavan A, Lee V, Batty R | eng | null | Journal Article, Review | null | IM | 22705184, S0009-9260(12)00164-X, 10.1016/j.crad.2012.03.018 | To establish whether paediatric centres within the Children's Cancer and Leukaemia Group (CCLG) network employ magnetic resonance imaging (MRI) protocols for brain tumours according to the revised guidance. | Brain Neoplasms, Child, Clinical Protocols, Guidelines as Topic, Humans, Magnetic Resonance Imaging, Surveys and Questionnaires, United Kingdom | null |
22,705,185 | 2013-02-11 | 2022-04-08 | 1365-229X | Clinical radiology | Radiology curriculum for undergraduate medical studies--a consensus survey. | Mirsadraee S, Mankad K, McCoubrie P, Roberts T, Kessel D | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705185, S0009-9260(12)00160-2, 10.1016/j.crad.2012.03.017 | To establish an expert consensus of what, when, and how the teaching of radiology should be incorporated into the core undergraduate medical curriculum. | Consensus, Curriculum, Delphi Technique, Education, Medical, Undergraduate, Humans, Radiology, United Kingdom | null |
22,705,186 | 2013-05-29 | 2012-11-20 | 1872-7727 | European journal of radiology | Magnetic resonance fiber density mapping of age-related white matter changes. | Stadlbauer Andreas, Ganslandt Oliver, Salomonowitz Erich, Buchfelder Michael, Hammen Thilo, Bachmair Johanna, Eberhardt Knut | eng | null | Journal Article | null | IM | 22705186, S0720-048X(12)00258-6, 10.1016/j.ejrad.2012.05.029 | To introduce fiber density mapping (FDM) for investigation of age-related white matter (WM) changes and to compare its capabilities with conventional diffusion tensor imaging (DTI) post-processing. | Adolescent, Adult, Aged, Aged, 80 and over, Aging, Brain, Diffusion Tensor Imaging, Female, Humans, Image Interpretation, Computer-Assisted, Imaging, Three-Dimensional, Male, Middle Aged, Nerve Fibers, Myelinated, Reproducibility of Results, Sensitivity and Specificity, Young Adult | null |
22,705,187 | 2013-03-22 | 2016-11-25 | 1872-7727 | European journal of radiology | The relationship between the prevalance and size of lumbar ossified ligamentum flavum and the presence and degree of facet joint degeneration. | Ergun Tarkan, Lakadamyali Hatice | eng | null | Journal Article | null | IM | 22705187, S0720-048X(12)00236-7, 10.1016/j.ejrad.2012.05.009 | To investigate whether there is any relationship between the prevalence and the dimension of OLF and the presence and degree of facet joint degeneration. In addition, it revealed the prevalence and distribution of lumbar OLF with regard to age and spinal levels. | Adolescent, Adult, Age Distribution, Aged, Arthrography, Female, Humans, Ligamentum Flavum, Lumbar Vertebrae, Male, Middle Aged, Ossification, Heterotopic, Prevalence, Risk Factors, Tomography, X-Ray Computed, Turkey, Young Adult, Zygapophyseal Joint | null |
22,705,188 | 2013-09-04 | 2016-11-25 | 1464-3391 | Bioorganic & medicinal chemistry | Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors. | Compain Guillaume, Martin-Mingot Agnès, Maresca Alfonso, Thibaudeau Sebastien, Supuran Claudiu T | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antigens, Neoplasm, Carbonic Anhydrase Inhibitors, Sulfonamides, Fluorine, Carbonic Anhydrase I, Carbonic Anhydrase II, CA9 protein, human, Carbonic Anhydrase IX, Carbonic Anhydrases, carbonic anhydrase XII | IM | 22705188, S0968-0896(12)00411-7, 10.1016/j.bmc.2012.05.037 | A series of new, halogen containing N-substituted 4-aminobenzenesulfonamides were synthesized by using superacid HF/SbF5 chemistry and investigated as inhibitors of several human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, that is, the cytosolic hCA I and II and, the tumor-associated transmembrane isoforms hCA IX and XII. Despite the substitution of the sulfonamide function, the presence of fluorine atom(s) in β position of the sulfonamide function strongly favors hCA inhibition. A similar effect of the β-fluorinated alkyl substitution on the amino function has been also observed. Among the tested compounds, several chlorinated derivatives have been identified as selective nanomolar, tumor-associated isoforms inhibitors. These non-primary sulfonamides probably bind in the coumarin-binding site, at the entrance of the cavity, and not to the metal ion as the primary sulfonamide inhibitors. | Antigens, Neoplasm, Binding Sites, Carbonic Anhydrase I, Carbonic Anhydrase II, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Carbonic Anhydrases, Catalytic Domain, Fluorine, Humans, Molecular Docking Simulation, Neoplasms, Protein Binding, Structure-Activity Relationship, Sulfonamides | null |
22,705,183 | 2014-01-14 | 2013-03-04 | 1545-7206 | Psychosomatics | Lysis of catatonic withdrawal by propofol in a bone-marrow transplant recipient with adenovirus limbic encephalitis. | Alfson Elizabeth D, Awosika Oluwole O, Singhal Tarun, Fricchione Gregory L | eng | null | Case Reports, Journal Article | Hypnotics and Sedatives, Benzodiazepines, Tacrolimus, Propofol | IM | 22705183, S0033-3182(12)00044-8, 10.1016/j.psym.2012.03.003 | null | Adenovirus Infections, Human, Anxiety Disorders, Benzodiazepines, Bone Marrow Transplantation, Catatonia, Diagnosis, Differential, Fatal Outcome, Female, Herpesvirus 6, Human, Humans, Hypnotics and Sedatives, Immunocompromised Host, Leukemia, Prolymphocytic, T-Cell, Limbic Encephalitis, Middle Aged, Propofol, Psychomotor Agitation, Tacrolimus | null |
22,705,189 | 2012-11-02 | 2021-10-21 | 1464-3391 | Bioorganic & medicinal chemistry | Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases. | Mak Lok Hang, Knott Jessica, Scott Katherine A, Scott Claire, Whyte Gillian F, Ye Yu, Mann David J, Ces Oscar, Stivers James, Woscholski Rudiger | eng | R01 GM056834 (NIGMS NIH HHS, United States); R01 GM068626 (NIGMS NIH HHS, United States); GM068626 (NIGMS NIH HHS, United States); GM056834 (NIGMS NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't | Enzyme Inhibitors, Organometallic Compounds, Propionates, Antimony, cdc25 Phosphatases | IM | 22705189, S0968-0896(12)00414-2, 10.1016/j.bmc.2012.05.040, PMC3389297, NIHMS380016, 18508107, 17057753, 17328562, 10962003, 17568790, 15474001, 9192810, 17240976, 17135270, 19410499, 16039589, 8995372, 9873717, 15147864, 10702277, 9817026, 21643420, 12014959, 18042731, 15324805 | Arylstibonates structurally resemble phosphotyrosine side chains in proteins and here we addressed the ability of such compounds to act as inhibitors of a panel of mammalian tyrosine and dual-specificity phosphatases. Two arylstibonates both possessing a carboxylate side chain were identified as potent inhibitors of the protein tyrosine phosphatase PTP-ß. In addition, they inhibited the dual-specificity, cell cycle regulatory phosphatases Cdc25a and Cdc25b with sub-micromolar potency. However, the Cdc25c phosphatase was not affected demonstrating that arylstibonates may be viable leads from which to develop isoform specific Cdc25 inhibitors. | Antimony, Enzyme Inhibitors, Kinetics, Organometallic Compounds, Propionates, Structure-Activity Relationship, cdc25 Phosphatases | null |
22,705,190 | 2012-11-02 | 2016-11-25 | 1464-3391 | Bioorganic & medicinal chemistry | Synthesis and evaluation of a radioiodinated bladder cancer specific peptide. | Ha Yeong Su, Lee Hwa Young, An Gwang Il, Kim Jonghee, Kwak Wonjung, Lee Eun-Ju, Lee Seung-Min, Lee Byung-Heon, Kim In-San, Belay Takele, Lee Woonghee, Ahn Byeong-Cheol, Lee Jaetae, Yoo Jeongsoo | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Iodine Radioisotopes, Peptides, Radiopharmaceuticals | IM | 22705190, S0968-0896(12)00435-X, 10.1016/j.bmc.2012.05.049 | Bladder cancer is the second most common cancer of the urinary tract, however the invasive cystoscopy is still the standard technique for diagnosis and surveillance of bladder cancer. Herein, we radiolabel bladder cancer specific peptide with radioactive iodine ((131/124)I) and evaluate its potential as a new radiopharmaceutical for the non-invasive diagnosis of bladder cancer. A 9-mer bladder cancer specific peptide (BP) was conjugated with tyrosine and cyclized by disulfide bond formation to give Y-BP, which was further radioiodinated to give [(131/124)I]Y-BP in good radiochemical yield. The biodistribution data showed the high selectivity of [(124)I]Y-BP in HT1376 human bladder cancer xenograft models with a tumor-to-muscle ratio of 6.2. This tumor targeting was not observed in control B16F10 melanoma tumor models. In microPET studies, while the control scrambled peptide, [(124)I]Y-sBP, did not accumulate in either the bladder cancer or melanoma, [(124)I]Y-BP showed high tumor uptake only in animals with HT1376 bladder cancer cells. Furthermore, [(124)I]Y-BP showed superior bladder cancer uptake even compared to most commonly used cancer imaging tracer, [(18)F]FDG. The experimental results suggest the potential of [(124)I]Y-BP as a new radiopharmaceutical for the non-invasive diagnosis of bladder cancer with high binding affinity and selectivity. | Amino Acid Sequence, Animals, Cell Line, Tumor, Cyclization, Humans, Iodine Radioisotopes, Melanoma, Experimental, Mice, Peptides, Positron-Emission Tomography, Protein Stability, Radiopharmaceuticals, Tissue Distribution, Transplantation, Heterologous, Urinary Bladder Neoplasms | null |
22,705,191 | 2012-11-02 | 2013-11-21 | 1464-3391 | Bioorganic & medicinal chemistry | Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives. | Okaecwe Thokozile, Swanepoel Abraham J, Petzer Anél, Bergh Jacobus J, Petzer Jacobus P | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Monoamine Oxidase Inhibitors, Protein Isoforms, Recombinant Proteins, Caffeine, Monoamine Oxidase | IM | 22705191, S0968-0896(12)00422-1, 10.1016/j.bmc.2012.05.048 | A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives with potent MAO inhibitory activities, and to contribute to the known structure-activity relationships of MAO inhibition by caffeine derived compounds, the present study investigates the MAO inhibitory potencies of series of 8-phenoxymethylcaffeine and 8-[(phenylsulfanyl)methyl]caffeine derivatives. The results document that the 8-phenoxymethylcaffeine derivatives act as potent reversible inhibitors of MAO-B, with IC(50) values ranging from 0.148 to 5.78 μM. In contrast, the 8-[(phenylsulfanyl)methyl]caffeine derivatives were found to be weak inhibitors of MAO-B, with IC(50) values ranging from 4.05 to 124 μM. Neither the 8-phenoxymethylcaffeine nor the 8-[(phenylsulfanyl)methyl]caffeine derivatives exhibited high binding affinities for MAO-A. While less potent than the 8-benzyloxycaffeines as MAO-B inhibitors, this study concludes that 8-phenoxymethylcaffeines may act as useful leads for the design of MAO-B selective inhibitors. Such compounds may find application in the therapy of neurodegenerative disorders such as Parkinson's disease. Using molecular docking experiments, this study also proposes possible binding orientations of selected caffeine derivatives in the active sites of MAO-A and -B. | Binding Sites, Caffeine, Catalytic Domain, Computer Simulation, Humans, Kinetics, Monoamine Oxidase, Monoamine Oxidase Inhibitors, Protein Isoforms, Recombinant Proteins, Structure-Activity Relationship | null |
22,705,197 | 2012-11-29 | 2012-07-23 | 1873-7838 | Cognition | The folk conception of knowledge. | Starmans Christina, Friedman Ori | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705197, S0010-0277(12)00109-6, 10.1016/j.cognition.2012.05.017 | How do people decide which claims should be considered mere beliefs and which count as knowledge? Although little is known about how people attribute knowledge to others, philosophical debate about the nature of knowledge may provide a starting point. Traditionally, a belief that is both true and justified was thought to constitute knowledge. However, philosophers now agree that this account is inadequate, due largely to a class of counterexamples (termed "Gettier cases") in which a person's justified belief is true, but only due to luck. We report four experiments examining the effect of truth, justification, and "Gettiering" on people's knowledge attributions. These experiments show that: (1) people attribute knowledge to others only when their beliefs are both true and justified; (2) in contrast to contemporary philosophers, people also attribute knowledge to others in Gettier situations; and (3) knowledge is not attributed in one class of Gettier cases, but only because the agent's belief is based on "apparent" evidence. These findings suggest that the lay concept of knowledge is roughly consistent with the traditional account of knowledge as justified true belief, and also point to a major difference between the epistemic intuitions of laypeople and those of philosophers. | Adolescent, Adult, Aged, Aged, 80 and over, Analysis of Variance, Causality, Culture, Female, Humans, Intuition, Knowledge, Male, Middle Aged, Thinking, Young Adult | null |
22,705,195 | 2013-01-09 | 2012-08-08 | 1873-6130 | Economics and human biology | The dramatic increase in obesity among Americans is no secret. | Wilson Sven E, Crosnoe Robert, Daniels Kellie | eng | null | Introductory Journal Article | null | IM | 22705195, S1570-677X(12)00074-3, 10.1016/j.ehb.2012.05.003 | null | Adolescent, Adult, Age Factors, Body Weight, Child, Family Health, Forecasting, Humans, Incidence, Obesity, United States, Young Adult | null |
22,705,196 | 2014-01-24 | 2013-04-19 | 2210-741X | Clinics and research in hepatology and gastroenterology | Intraductal thermal injury using a heat probe and radiofrequency ablation electrode in a swine model of biliary stenosis. | Shin Jae Uk, Lee Kwang Hyuck, Kim Su-A, Choi Jong Hak, Kim Kwang Min, Lee Jong Kyun, Lee Kyu Taek, Choi Yoon-La | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705196, S2210-7401(12)00132-5, 10.1016/j.clinre.2012.04.013 | An animal model for bile duct stenosis using intraductal thermal injury has not yet been established. The aims of the current study were to develop biliary stenosis in a swine model by inducing intraductal thermal injury using a heat probe or radiofrequency ablation electrode and to investigate an effective and safe energy dose. | Animals, Biliary Tract Diseases, Cholangiography, Common Bile Duct, Constriction, Pathologic, Disease Models, Animal, Electrocoagulation, Swine | null |
22,705,199 | 2012-11-26 | 2018-12-01 | 1878-5905 | Biomaterials | Mechanisms of transcellular transport of wheat germ agglutinin-functionalized polymeric nanoparticles in Caco-2 cells. | Song Qingxiang, Yao Lei, Huang Meng, Hu Quanyin, Lu Qin, Wu Bingxian, Qi Hong, Rong Zhengxing, Jiang Xinguo, Gao Xiaoling, Chen Jun, Chen Hongzhuan | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Coumarins, Drug Carriers, Mutant Proteins, Wheat Germ Agglutinins, monomethoxypolyethyleneglycol-polylactide block copolymer, poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer, Polyglactin 910, Polyethylene Glycols, rab GTP-Binding Proteins | IM | 22705199, S0142-9612(12)00620-5, 10.1016/j.biomaterials.2012.05.066 | Transcellular transport is essential for transmucosal and plasma-to-tissue drug delivery by nanoparticles, whereas its fundamental pathways have not been fully clarified. In this study, an in-depth investigation was conducted into the intracellular itinerary and the transcytosis pathway of wheat germ agglutinin-functionalized nanoparticles (WGA-NP) with various polymer architectures in the Caco-2 cell model. GFP-Rabs, Rab4, Rab5, Rab7, Rab11, GTPases served as key regulators of vesicular transport, and their mutants were transfected to Caco-2 cells respectively to determine the cellular itinerary of WGA-NP and the role of Rabs therein. Transcytosis inhibition experiments indicated that transcellular transport of WGA-NP (PEG(3000)-PLA(40000) formulation) happened in a cytoskeleton-dependent manner and majorly by means of clathrin-mediated mechanism. Intracellular transport, especially the endolysosome pathway was found largely contribute to the transcytosis of WGA-NP. WGA-NP with shorter surface PEG length (2000) resulted in higher cellular association and more colocalization with the clathrin-mediated transport pathway, while that with longer surface PEG length (5000) avoided the clathrin-mediated transport pathway but achieved higher transcytosis after 4 h incubation. WGA-NP with PLGA as the core materials obtained elevated lysosome escape and enhanced transcytosis after 2 h incubation. These findings provided important evidence for the role of polymer architectures in modulating cellular transport of functionalized nanocarriers, and would be helpful in improving carrier design to enhance drug delivery. | Caco-2 Cells, Coumarins, Drug Carriers, Genetic Vectors, Humans, Microscopy, Confocal, Microscopy, Electron, Transmission, Mutant Proteins, Nanoparticles, Particle Size, Polyethylene Glycols, Polyglactin 910, Transcytosis, Wheat Germ Agglutinins, rab GTP-Binding Proteins | null |
22,705,192 | 2013-07-19 | 2017-11-16 | 1878-3279 | Immunobiology | The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis. | Toldi Gergely, Bajnok Anna, Dobi Diána, Kaposi Ambrus, Kovács László, Vásárhelyi Barna, Balog Attila | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Intermediate-Conductance Calcium-Activated Potassium Channels, KCNN4 protein, human, Kv1.3 Potassium Channel, Potassium Channel Blockers, Scorpion Venoms, margatoxin | IM | 22705192, S0171-2985(12)00116-7, 10.1016/j.imbio.2012.05.013 | The transient increase of the cytoplasmic free calcium level plays a key role in the process of lymphocyte activation. Kv1.3 and IKCa1 potassium channels are important regulators of the maintenance of calcium influx during lymphocyte activation and present a possible target for selective immunomodulation. | Adult, Arthritis, Rheumatoid, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Calcium Signaling, Case-Control Studies, Female, Humans, Intermediate-Conductance Calcium-Activated Potassium Channels, Kv1.3 Potassium Channel, Lymphocyte Activation, Male, Middle Aged, Molecular Targeted Therapy, Potassium Channel Blockers, Scorpion Venoms, Th1 Cells, Th2 Cells | null |
22,705,198 | 2012-11-29 | 2019-12-10 | 1873-7838 | Cognition | Representation of numerical and non-numerical order in children. | Berteletti Ilaria, Lucangeli Daniela, Zorzi Marco | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705198, S0010-0277(12)00107-2, 10.1016/j.cognition.2012.05.015 | The representation of numerical and non-numerical ordered sequences was investigated in children from preschool to grade 3. The child's conception of how sequence items map onto a spatial scale was tested using the Number-to-Position task (Siegler & Opfer, 2003) and new variants of the task designed to probe the representation of the alphabet (i.e., letter sequence) and the calendar year (i.e., month sequence). The representation of non-numerical order showed the same developmental pattern previously observed for numerical representation, with a logarithmic mapping in the youngest children and a shift to linear mapping in older children. Although the individual ability to position non-numerical items was related to the child's knowledge of the sequence, a significant amount of unique variance was explained by her type of number-line representation. These results suggest that the child's conception of numerical order is generalized to non-numerical sequences and that the concept of linearity is acquired in the numerical domain first and progressively extended to all ordinal sequences. | Aging, Analysis of Variance, Child, Child Development, Child, Preschool, Concept Formation, Female, Generalization, Psychological, Humans, Male, Mathematics, Mental Processes | null |
22,705,200 | 2012-11-29 | 2012-08-03 | 1872-7492 | Virus research | Generation and characterization of a Cowpox virus mutant lacking host range factor CP77. | Schuenadel Livia, Tischer B Karsten, Nitsche Andreas | eng | null | Journal Article | Viral Proteins | IM | 22705200, S0168-1702(12)00202-X, 10.1016/j.virusres.2012.06.005 | Cowpox virus (CPXV) host range factor CP77 was identified to be required for virus replication in Chinese hamster ovary (CHO) cells, but the underlying molecular mechanism by which CP77 modulates host range has remained unclear. Therefore, a CPXVΔCP77 deletion mutant was constructed by applying bacterial artificial chromosome (BAC) technology. Integrity of BAC-derived viral DNA was confirmed by whole genome sequencing. In vitro growth characteristics of CPXV wild type (WT), BAC-derived vCPXV WT and vCPXVΔCP77 were virtually indistinguishable in HEK293T cells, whereas in CHO-K1 cells replication of virus lacking CP77 was unambiguously attenuated. This block of viral replication was confirmed by lack of late viral protein expression. The replication defect of various Orthopoxviruses lacking CP77 in CHO cells could be restored by recombinant expression of CP77. Thus, for the first time, the described CP77-dependent host range effect in CHO cells was shown in the background of CPXV as well as Camelpox virus. To further characterize the mutant virus, cells of several different species were comparably infected with vCPXV WT and vCPXVΔCP77, respectively. Interestingly, except for CHO-K1 cells, vCPXV WT and vCPXVΔCP77 showed no significant difference in terms of morphology of cytopathic effects, expression of a late transcribed virus-encoded green fluorescent protein and virus reproduction, even in other hamster-derived cells. Additionally, in ovo inoculation with either virus revealed the same red-pock phenotype on chicken egg chorioallantoic membranes. Since the data presented indicate a CP77-dependent host range effect only for CHO cells, we conclude that the protein might mediate additional functions not identified yet. The vCPXVΔCP77 deletion mutant generated can now be applied as a useful tool to investigate the function of the putative host range protein CP77. | Animals, Cell Line, Cowpox, Cowpox virus, Cricetinae, Host Specificity, Humans, Sequence Deletion, Viral Proteins, Virus Replication | null |
22,705,193 | 2013-03-08 | 2013-11-21 | 1096-0961 | Blood cells, molecules & diseases | Splenectomy is a risk factor for developing hyperuricemia and nephrolithiasis in patients with thalassemia intermedia: a retrospective study. | Ricchi Paolo, Ammirabile Massimiliano, Costantini Silvia, Di Matola Tiziana, Spasiano Anna, Genna Maria Ludovica, Cinque Patrizia, Prossomariti Luciano | eng | null | Journal Article | Uric Acid, Creatinine | IM | 22705193, S1079-9796(12)00123-4, 10.1016/j.bcmd.2012.05.012 | Few data are available on the prevalence and the risk factors for the presence of kidney stones and hyperuricemia in patients with thalassemia intermedia. We retrospectively reviewed the charts and radiological studies of 89 patients with thalassemia intermedia followed at our clinic with routine biochemical examination and radiological imaging of the urinary tract. Renal calculi were identified in 11 patients (12%) and 22 patients (25%) were under uricosuric treatment for hyperucemia. The prevalence of nephrolithiasis increased with age but not in a statistically significant manner. Major risk factors for renal stone formation were splenectomy (in 91% of the cases) and higher number of erythroblasts. Patients with renal stones had higher mean creatinine level and lower GFR value with respect to those observed in patients not affected. Our data suggest that splenectomy, by further increasing erythrocyte turnover and number, may be directly involved in the pathogenesis of hyperuricemia and nephrolithiasis observed in thalassemia intermedia patients. | Adolescent, Adult, Age Factors, Aged, Creatinine, Erythroblasts, Erythrocyte Count, Erythrocytes, Female, Glomerular Filtration Rate, Humans, Hyperuricemia, Kidney Calculi, Male, Middle Aged, Retrospective Studies, Risk Factors, Splenectomy, Uric Acid, beta-Thalassemia | null |
22,705,202 | 2012-11-05 | 2012-09-04 | 1096-0384 | Archives of biochemistry and biophysics | Anti-bacterial monoclonal antibodies: back to the future? | Oleksiewicz Martin B, Nagy Gábor, Nagy Eszter | eng | null | Journal Article, Review | Anti-Bacterial Agents, Antibodies, Monoclonal | IM | 22705202, S0003-9861(12)00246-9, 10.1016/j.abb.2012.06.001 | Today's medicine has to deal with the emergence of multi-drug resistant bacteria, and is beginning to be confronted with pan-resistant microbes. This worsening inadequacy of the antibiotics concept, which has ruled infectious medicine in the last six decades creates an increasing unmet medical need that can be addressed by passive immunization. While past experience from the pre-antibiotic era with serum therapy was in many cases encouraging, antibacterial monoclonal antibodies have so far suffered high attrition rates in the clinic, generally from lack of efficacy. Yet, we believe that recent developments in a number of areas such as infectious disease pathogenesis research, translational medicine, mAb engineering, mAb manufacturing and rapid bedside diagnostics are converging to make the medium-term future permissive for antibacterial mAb development. Here, we review antibacterial mAb-based approaches that are or were in clinical development, and may potentially act as paradigms with regards to molecular targets, antibody formats and mode-of-action, pre-clinical validation and selection of most relevant patient populations, in order to increase the likelihood of successful product development in this field. | Animals, Anti-Bacterial Agents, Antibodies, Monoclonal, Bacteria, Bacterial Infections, Drug Discovery, Drug Resistance, Bacterial, Humans | null |
22,705,194 | 2013-05-28 | 2021-10-21 | 1879-1336 | Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology | The effect of C1 inhibitor on myocardial ischemia and reperfusion injury. | Lu Fengxin, Fernandes Stacey M, Davis Alvin E | eng | R01 AI057366 (NIAID NIH HHS, United States); R37 HD022082 (NICHD NIH HHS, United States); R37-HD22082 (NICHD NIH HHS, United States); R01-AI057366 (NIAID NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural | Biomarkers, Complement C1 Inhibitor Protein, Complement C3, Serping1 protein, mouse, Troponin I | IM | 22705194, S1054-8807(12)00057-9, 10.1016/j.carpath.2012.05.003, PMC3449044, NIHMS380021, 12472776, 11956243, 1868978, 2930506, 11733575, 11673555, 17576071, 12398824, 10601349, 11087237, 9815095, 12547703, 9681790, 19747734, 15879149, 641147, 2060111, 10556930, 8957415, 2244865, 9024160, 9843832, 10698339, 4993831, 2379317, 7882499, 18787060, 10330240, 9239393, 8182345, 8013522, 1888745, 16616762, 20019324, 10699156, 11257302, 8994423, 2698962, 10403475, 11748112, 8185717, 7805243, 2371562, 9631876, 11356621, 2010056, 8317336, 11057674, 10615413, 9655888, 7532174, 8476062 | Activation of the complement system has been demonstrated to be an important mechanism in the mediation of myocardial ischemia and reperfusion (MIR) injury. C1 inhibitor (C1INH) has been shown to be beneficial in experimental MIR models. The underlying mechanism of this effect has been assumed to result primarily from inhibition of complement system activation. We recently demonstrated that C1INH plays a direct role in suppression of leukocyte transmigration in the mouse intestinal ischemia and reperfusion model. The purpose of this study was to investigate the mechanism of the beneficial effect of C1INH in mouse MIR model. | Animals, Biomarkers, Chemotaxis, Leukocyte, Complement Activation, Complement C1 Inhibitor Protein, Complement C3, Disease Models, Animal, Injections, Intravenous, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Myocardial Infarction, Myocardial Reperfusion Injury, Myocardium, Neutrophil Infiltration, Troponin I | null |
22,705,204 | 2012-11-30 | 2022-04-10 | 1879-0135 | International journal for parasitology | The presence of Tregs does not preclude immunity to reinfection with Leishmania braziliensis. | C Falcão Sarah, de Moura Tatiana R, Clarêncio Jorge, Brodskyn Cláudia, Barral Aldina, de Oliveira Camila I | eng | null | Journal Article | null | IM | 22705204, S0020-7519(12)00145-2, 10.1016/j.ijpara.2012.05.006 | Leishmania spp. cause a broad spectrum of diseases collectively known as leishmaniasis. Leishmania braziliensis is the main etiological agent of American cutaneous leishmaniasis and mucocutaneous leishmaniasis. During experimental infection with L. braziliensis, BALB/c mice develop an adaptive immune response that is associated with lesion healing and, in parallel, parasite persistence within draining lymph nodes (dLNs). In the Leishmania major model of cutaneous leishmaniasis, regulatory T cells (Tregs) play an important role in immune regulation, preventing pathological immune responses but at the same time precluding sterile cure. In this study we investigated the role of Tregs during experimental infection with L. braziliensis. CD4(+)CD25(+) T cells were detected throughout the duration of clinical disease both at the ear and in dLNs of infected mice. These cells expressed Treg markers such as glucocorticoid-induced TNF-receptor-related protein (GITR), the α chain of the αεβ7 integrin (CD103), and the forkhead/winged helix transcription factor, Foxp3, and were able to suppress the proliferation of CD4(+)CD25(-) cells. Importantly, a high frequency of Foxp3(+) cells accumulated at the site of infection and in dLNs. We next investigated the outcome of a reinfection with L. braziliensis in terms of Treg distribution and disease reactivation. Interestingly, a secondary inoculation with L. braziliensis did not preclude an efficient recall response to L. braziliensis at a distal site, despite the presence of Tregs. Within dLNs, reinfection did not promote parasite dissemination or a differential recruitment of either CD4(+)CD25(+)Foxp3(+) or CD4(+)IL-10(+) T cells. On the contrary, parasites were mainly detected in the LN draining the primary infection site where a high frequency of CD4(+)IFN-γ(+) T cells was also present. Collectively these data show that during experimental infection, Tregs are present in healed mice but this population does not compromise an effective immune response upon reinfection with L. braziliensis. | Animals, Female, Humans, Immunity, Leishmania braziliensis, Leishmaniasis, Mice, Mice, Inbred BALB C, T-Lymphocytes, Regulatory | null |
22,705,203 | 2012-11-30 | 2012-07-17 | 1879-0135 | International journal for parasitology | The importance of being regular: Caenorhabditis elegans and Pristionchus pacificus defecation mutants are hypersusceptible to bacterial pathogens. | Rae Robbie, Witte Hanh, Rödelsperger Christian, Sommer Ralf J | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Helminth Proteins | IM | 22705203, S0020-7519(12)00144-0, 10.1016/j.ijpara.2012.05.005 | Bacterial pathogens have shaped the evolution and survival of organisms throughout history, but little is known about the evolution of virulence mechanisms and the counteracting defence strategies of host species. The nematode model organisms, Caenorhabditis elegans and Pristionchus pacificus, feed on a wealth of bacteria in their natural soil environment, some of which can cause mortality. Previously, we have shown that these nematodes differ in their susceptibility to a range of human and insect pathogenic bacteria, with P. pacificus showing extreme resistance compared with C. elegans. Here, we isolated 400 strains of Bacillus from soil samples and fed their spores to both nematodes. Spores of six Bacillus strains were found to kill C. elegans but not P. pacificus. While the majority of Bacillus strains are benign to nematodes, observed pathogenicity is restricted to either the spore or the vegetative stage. We used the rapid C. elegans killer strain (Bacillus sp. 142) to conduct a screen for hypersusceptible P. pacificus mutants. Two P. pacificus mutants with severe muscle defects and an extended defecation cycle that die rapidly on Bacillus spores were isolated. These genes were identified to be homologous to C. elegans, unc-22 and unc-13. To test whether a similar relationship between defecation and bacterial pathogenesis exists in C. elegans, we used five known defecation mutants. Quantification of the defecation cycle in mutants also revealed a severe effect on survival in C. elegans. Thus, intestinal peristalsis is critical to nematode health and contributes significantly to survival when fed Gram-positive bacteria. | Animals, Bacillus, Caenorhabditis elegans, Helminth Proteins, Host-Pathogen Interactions, Molecular Sequence Data, Mutation, Nematoda, Soil Microbiology, Species Specificity, Staphylococcus aureus, Virulence | null |
22,705,201 | 2012-10-31 | 2023-12-13 | 1096-0384 | Archives of biochemistry and biophysics | Structural studies of N-terminal mutants of connexin 32 using (1)H NMR spectroscopy. | Kalmatsky B D, Batir Y, Bargiello T A, Dowd T L | eng | R01 GM046889 (NIGMS NIH HHS, United States); GM46889 (NIGMS NIH HHS, United States); ES009032 (NIEHS NIH HHS, United States); R01 GM098584 (NIGMS NIH HHS, United States); R01 ES009032 (NIEHS NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural | Connexins, Mutant Proteins, Peptide Fragments, Solutions | IM | 22705201, S0003-9861(12)00245-7, 10.1016/j.abb.2012.05.027, PMC3938314, NIHMS398615, 22037495, 19944606, 9364054, 19638273, 9757107, 4510294, 11032405, 2261440, 18372303, 20584891, 11053119, 2843644, 19340074, 6487311, 3233287, 10469726, 22911360, 8756691, 18831677, 10646523, 11325342, 8266101, 8744573, 7559494, 8520220, 7881270, 1507227, 8127371, 15094346, 8391867, 9878458, 16492141, 19277060, 18695008, 10825424, 22006989, 11463644, 1490109, 10207897, 8845350, 4351002, 15298899 | The amino terminus of gap junction proteins, connexins, plays a fundamental role in voltage gating and ion permeation. We have previously shown with (1)H NMR that the structure of the N-terminus of functional connexin molecules contains a flexible turn around G12 (Arch. Biochem. Biophys.490:9,2009) allowing the N-terminus to form a portion of the channel pore near the cytoplasmic entrance. The mutants of nonfunctional connexin molecules G12S and G12Y were found to prevent this turn. Previous functional studies of loci at which Cx32 mutations cause a peripheral neuropathy, Charcot-Marie-Tooth disease, have shown that G12S is not plasma membrane inserted. Presently, we solve the structure of nonfunctional Connexin 32 mutants W3D and Y7D which do not appear to be membrane inserted. Using 2D (1)H NMR, we report that similar to G12S and G12Y, alterations in hydrophobic sidechain interactions disrupt (Y7D) or constrain (W3D) the flexible turn around G12. The alteration in the open turn around residue 12, observed in all nonfunctional mutants G12S, G12Y, W3D and Y7D correlates with loss of function. We propose that loss of the open turn causes the N-terminus to extend out of the channel pore and this misfolding may target mutants for destruction in the endoplasmic reticulum. | Amino Acid Sequence, Connexins, Models, Molecular, Molecular Sequence Data, Mutant Proteins, Mutation, Nuclear Magnetic Resonance, Biomolecular, Peptide Fragments, Protein Conformation, Solutions, Gap Junction beta-1 Protein | null |
22,705,205 | 2013-01-15 | 2021-10-21 | 0006-3002 | Biochimica et biophysica acta | TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: a dominant role for Smad-2. | Michael Daryn R, Salter Rebecca C, Ramji Dipak P | eng | PG/08/073/25520 (British Heart Foundation, United Kingdom) | Journal Article, Research Support, Non-U.S. Gov't | CD36 Antigens, Lipoproteins, LDL, SMAD2 protein, human, SMAD3 protein, human, Scavenger Receptors, Class A, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta, Cholesterol, Lipoprotein Lipase | IM | 22705205, S0925-4439(12)00136-6, 10.1016/j.bbadis.2012.06.002, PMC3497875, 11352993, 1556191, 21830321, 11348881, 1744079, 17785805, 17056295, 15980430, 14534577, 17073770, 19041276, 14993291, 20543107, 15755745, 16728653, 18506886, 20410491, 19238796, 16139837, 21336306, 1436033, 15963479, 14992729, 12193044, 21601592, 16269335, 16105881, 19942084, 7675764, 14707038, 1999239, 218198, 21334453, 15166010, 17340614, 18460328, 20057170, 10625669, 11742878, 19074480, 10749696, 8947549, 16601234, 10468518, 19795348, 11418665, 17885219, 14568988, 11701621, 16614444, 15136587 | The anti-atherogenic cytokine, TGF-β, plays a key role during macrophage foam cell formation by modulating the expression of key genes involved in the control of cholesterol homeostasis. Unfortunately, the molecular mechanisms underlying these actions of TGF-β remain poorly understood. In this study we examine the effect of TGF-β on macrophage cholesterol homeostasis and delineate the role of Smads-2 and -3 during this process. Western blot analysis showed that TGF-β induces a rapid phosphorylation-dependent activation of Smad-2 and -3 in THP-1 and primary human monocyte-derived macrophages. Small interfering RNA-mediated knockdown of Smad-2/3 expression showed that the TGF-β-mediated regulation of key genes implicated in the uptake of modified low density lipoproteins and the efflux of cholesterol from foam cells was Smad-dependent. Additionally, through the use of virally delivered Smad-2 and/or Smad-3 short hairpin RNA, we demonstrate that TGF-β inhibits the uptake of modified LDL by macrophages through a Smad-dependent mechanism and that the TGF-β-mediated regulation of CD36, lipoprotein lipase and scavenger receptor-A gene expression was dependent on Smad-2. These studies reveal a crucial role for Smad signaling, particularly Smad-2, in the inhibition of foam cell formation by TGF-β through the regulation of expression of key genes involved in the control of macrophage cholesterol homeostasis. | CD36 Antigens, Cells, Cultured, Cholesterol, Foam Cells, Gene Expression, Homeostasis, Humans, Lipoprotein Lipase, Lipoproteins, LDL, Macrophages, Phosphorylation, Scavenger Receptors, Class A, Signal Transduction, Smad2 Protein, Smad3 Protein, Transforming Growth Factor beta | null |
22,705,206 | 2013-01-15 | 2016-11-26 | 0006-3002 | Biochimica et biophysica acta | Higher susceptibility to amyloid fibril formation of the recombinant ovine prion protein modified by transglutaminase. | Sorrentino Angela, Giosafatto Concetta Valeria L, Sirangelo Ivana, De Simone Carmela, Di Pierro Prospero, Porta Raffaele, Mariniello Loredana | eng | null | Journal Article | Amyloid, Prions, Protein Isoforms, Recombinant Proteins, Transglutaminases, Endopeptidase K | IM | 22705206, S0925-4439(12)00137-8, 10.1016/j.bbadis.2012.06.003 | Prion proteins are known as the main agents of transmissible spongiform encephalopathies affecting humans as well as animals. A recombinant ovine prion protein was found to be in vitro able to act as an effective substrate for a microbial isoform of transglutaminase, an enzyme catalyzing the formation of isopeptide bonds inside the proteins. We proved that transglutaminase modifies the structure of the prion protein by leading to the formation of three intra-molecular crosslinks and that the crosslinked protein form is more competent in amyloid formation compared to the unmodified one. In addition, the crosslinked prion protein was shown also to be more resistant to proteinase K digestion. Our findings suggest a possible use of transglutaminase in stabilizing the prion protein three-dimensional structure in order to investigate the molecular basis of the conversion of the protein into its pathological form. | Amino Acid Sequence, Amyloid, Animals, Endopeptidase K, Kinetics, Molecular Sequence Data, Prion Diseases, Prions, Protein Binding, Protein Isoforms, Recombinant Proteins, Sheep, Transglutaminases | null |
22,705,209 | 2012-11-02 | 2024-08-29 | 1878-4186 | Structure (London, England : 1993) | Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain. | Yuchi Zhiguang, Lau Kelvin, Van Petegem Filip | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S. | Protein Isoforms, Recombinant Proteins, Ryanodine Receptor Calcium Release Channel, Cyclic AMP-Dependent Protein Kinases, Calcium | IM | 22705209, S0969-2126(12)00174-8, 10.1016/j.str.2012.04.015 | Ryanodine Receptors (RyRs) are huge Ca²⁺ release channels in the endoplasmic reticulum membrane and form targets for phosphorylation and disease mutations. We present crystal structures of a domain in three RyR isoforms, containing the Ser2843 (RyR1) and Ser2808/Ser2814 (RyR2) phosphorylation sites. The RyR1 domain is the target for 11 disease mutations. Several of these are clustered near the phosphorylation sites, suggesting that phosphorylation and disease mutations may affect the same interface. The L2867G mutation causes a drastic thermal destabilization and aggregation at room temperature. Crystal structures for other disease mutants show that they affect surface properties and intradomain salt bridges. In vitro phosphorylation experiments show that up to five residues in one long loop of RyR2 can be phosphorylated by PKA or CaMKII. Docking into cryo-electron microscopy maps suggests a putative location in the clamp region, implying that mutations and phosphorylation may affect the allosteric motions within this area. | Amino Acid Sequence, Animals, Bacteroides, Calcium, Cryoelectron Microscopy, Crystallography, X-Ray, Cyclic AMP-Dependent Protein Kinases, Humans, Mice, Models, Molecular, Molecular Sequence Data, Mutation, Phosphorylation, Protein Isoforms, Protein Structure, Secondary, Protein Structure, Tertiary, Rabbits, Recombinant Proteins, Ryanodine Receptor Calcium Release Channel, Sequence Alignment, Sequence Homology, Amino Acid | null |
22,705,207 | 2012-11-02 | 2022-04-10 | 1878-4186 | Structure (London, England : 1993) | Structure and proposed mechanism for the pH-sensing Helicobacter pylori chemoreceptor TlpB. | Goers Sweeney Emily, Henderson J Nathan, Goers John, Wreden Christopher, Hicks Kevin G, Foster Jeneva K, Parthasarathy Raghuveer, Remington S James, Guillemin Karen | eng | F32 AI091098 (NIAID NIH HHS, United States); R01 DK075667 (NIDDK NIH HHS, United States); AI091098-02 (NIAID NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S. | Bacterial Proteins, Protons, Receptors, Cell Surface, Recombinant Proteins, Urea | IM | 22705207, S0969-2126(12)00181-5, 10.1016/j.str.2012.04.021, PMC3392440, NIHMS380960, 1315053, 15731083, 10357859, 6145023, 19026766, 10722597, 21663441, 7009572, 8516329, 17517875, 15761078, 10338211, 8637911, 19858104, 1891020, 19659782, 2819054, 15664919, 15972267, 17628132, 11369857, 16990134, 21109532, 2904568, 16855050, 19748334, 21933915, 18165013, 12867417, 16547053, 21602215, 9098027, 20683624, 15299315, 12471160, 19864420, 21665965, 19805102, 10466731, 18258261, 19759826, 19748340, 15044704, 1891021, 14512417, 10481014, 19217390, 19332820, 21791582, 11700325, 1660187, 20008068 | pH sensing is crucial for survival of most organisms, yet the molecular basis of such sensing is poorly understood. Here, we present an atomic resolution structure of the periplasmic portion of the acid-sensing chemoreceptor, TlpB, from the gastric pathogen Helicobacter pylori. The structure reveals a universal signaling fold, a PAS domain, with a molecule of urea bound with high affinity. Through biophysical, biochemical, and in vivo mutagenesis studies, we show that urea and the urea-binding site residues play critical roles in the ability of H. pylori to sense acid. Our signaling model predicts that protonation events at Asp114, affected by changes in pH, dictate the stability of TlpB through urea binding. | Amino Acid Sequence, Bacterial Proteins, Binding Sites, Crystallography, X-Ray, Dimerization, Escherichia coli, Helicobacter pylori, Hydrogen-Ion Concentration, Models, Molecular, Molecular Sequence Data, Mutation, Plasmids, Protein Binding, Protein Stability, Protein Structure, Secondary, Protein Structure, Tertiary, Protons, Receptors, Cell Surface, Recombinant Proteins, Sequence Alignment, Signal Transduction, Urea | null |
22,705,210 | 2012-11-02 | 2022-03-09 | 1878-4186 | Structure (London, England : 1993) | An internal water-retention site in the rhomboid intramembrane protease GlpG ensures catalytic efficiency. | Zhou Yanzi, Moin Syed M, Urban Sinisa, Zhang Yingkai | eng | R01 AI066025 (NIAID NIH HHS, United States); R01 GM079223 (NIGMS NIH HHS, United States); GM079223 (NIGMS NIH HHS, United States); AI066025 (NIAID NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S. | DNA-Binding Proteins, Escherichia coli Proteins, GlpG protein, E coli, Lipid Bilayers, Membrane Proteins, Recombinant Proteins, Water, Endopeptidases | IM | 22705210, S0969-2126(12)00182-7, 10.1016/j.str.2012.04.022, PMC3571093, NIHMS392731, 12798692, 19458713, 17976648, 17463085, 18979634, 17190827, 19226105, 21256137, 14747309, 17649971, 17099694, 16211538, 15684070, 17956719, 16731967, 18440799, 17051161, 10693756, 22797666, 17912756, 9129804, 3504214, 9860871, 17243153, 20070259, 17179147, 17114579, 19278654, 17637346, 17210913, 19421188 | Rhomboid proteases regulate key cellular pathways, but their biochemical mechanism including how water is made available to the membrane-immersed active site remains ambiguous. We performed four prolonged molecular dynamics simulations initiated from both gate-open and gate-closed states of Escherichia coli rhomboid GlpG in a phospholipid bilayer. GlpG was notably stable in both gating states, experiencing similar tilt and local membrane thinning, with no observable gating transitions, highlighting that gating is rate-limiting. Analysis of dynamics revealed rapid loss of crystallographic waters from the active site, but retention of a water cluster within a site formed by His141, Ser181, Ser185, and/or Gln189. Experimental interrogation of 14 engineered mutants revealed an essential role for at least Gln189 and Ser185 in catalysis with no effect on structural stability. Our studies indicate that spontaneous water supply to the intramembrane active site of rhomboid proteases is rare, but its availability for catalysis is ensured by an unanticipated active site element, the water-retention site. | Biocatalysis, Catalytic Domain, Cell Membrane, Crystallography, X-Ray, DNA-Binding Proteins, Endopeptidases, Enzyme Stability, Escherichia coli, Escherichia coli Proteins, Hydrogen Bonding, Kinetics, Lipid Bilayers, Membrane Proteins, Molecular Dynamics Simulation, Mutation, Protein Binding, Protein Structure, Secondary, Recombinant Proteins, Water | null |
22,705,208 | 2012-11-02 | 2023-01-06 | 1878-4186 | Structure (London, England : 1993) | Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. | Wang Chaojian, Chung Ben C, Yan Haidun, Lee Seok-Yong, Pitt Geoffrey S | eng | R01 HL071165 (NHLBI NIH HHS, United States); R01 HL088089 (NHLBI NIH HHS, United States); R01 HL71165 (NHLBI NIH HHS, United States); DP2 OD008380 (NIH HHS, United States); 1 DP2 OD008380-01 (NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't | Calmodulin, NAV1.5 Voltage-Gated Sodium Channel, Protein Isoforms, Recombinant Proteins, SCN5A protein, human, Sodium Channels, fibroblast growth factor 13, Fibroblast Growth Factors, Calcium | IM | 22705208, S0969-2126(12)00180-3, 10.1016/j.str.2012.05.001, PMC3610540, NIHMS380959, 15525788, 17054685, 12123606, 16166153, 21817159, 27754618, 21665954, 12721618, 19027780, 12815063, 20351042, 8790420, 19406745, 15130477, 18804930, 20139964, 17978045, 16002579, 11376006, 15655131, 12401812, 21743477, 10627139, 19129176, 20194124, 16223877, 10449714, 17678857, 17928445, 17715345, 15316014, 10944333, 18708744, 11517324, 8263940, 15840476, 15572765, 12489043, 20124702, 17028172, 17347258, 21566136, 21167176, 21439835, 7529940, 19461840, 16505387, 7716527, 9653027, 18287503, 12967988, 20129283, 12859953, 12610651, 19074138 | Voltage-gated Na⁺ (Na(V)) channels initiate neuronal action potentials. Na(V) channels are composed of a transmembrane domain responsible for voltage-dependent Na⁺ conduction and a cytosolic C-terminal domain (CTD) that regulates channel function through interactions with many auxiliary proteins, including fibroblast growth factor homologous factors (FHFs) and calmodulin (CaM). Most ion channel structural studies have focused on mechanisms of permeation and voltage-dependent gating but less is known about how intracellular domains modulate channel function. Here we report the crystal structure of the ternary complex of a human Na(V) CTD, an FHF, and Ca²⁺-free CaM at 2.2 Å. Combined with functional experiments based on structural insights, we present a platform for understanding the roles of these auxiliary proteins in Na(V) channel regulation and the molecular basis of mutations that lead to neuronal and cardiac diseases. Furthermore, we identify a critical interaction that contributes to the specificity of individual Na(V) CTD isoforms for distinctive FHFs. | Action Potentials, Amino Acid Sequence, Binding Sites, Calcium, Calmodulin, Calorimetry, Crystallography, X-Ray, Escherichia coli, Fibroblast Growth Factors, Humans, Models, Molecular, Molecular Sequence Data, Mutation, NAV1.5 Voltage-Gated Sodium Channel, Plasmids, Protein Binding, Protein Isoforms, Protein Structure, Secondary, Protein Structure, Tertiary, Recombinant Proteins, Sequence Alignment, Sodium Channels, Structure-Activity Relationship | null |
22,705,211 | 2013-03-19 | 2021-10-21 | 1618-1298 | European journal of cell biology | Imaging of cell adhesion events in 3D matrix environments. | Jayo Asier, Parsons Maddy | eng | MR/J000647/1 (Medical Research Council, United Kingdom) | Journal Article, Research Support, Non-U.S. Gov't, Review | null | IM | 22705211, S0171-9335(12)00084-2, 10.1016/j.ejcb.2012.05.002 | Cell adhesion plays an essential role in development and homeostasis, but is also a key regulator of many diseases such as cancer and immune dysfunction. Numerous studies over the past three decades have revealed a wealth of information detailing signalling molecules required for cell adhesion to two-dimensional surfaces. However, in vivo many cells are completely surrounded by matrix and this will very likely influence the size, composition and dynamics of adhesive structures. The study of adhesion in cells within three-dimensional environments is still in its infancy, thus the role and regulation of adhesions in these complex environments remains unclear. The recent development of new experimental models coupled with significant advances in cell imaging approaches have provided platforms for researchers to begin to dissect adhesion signalling in cells in 3D matrices. Here we summarise the recent insights in cell adhesion formation and regulation in 3D model systems and the imaging approaches used to analyse these events. | Animals, Cell Adhesion, Extracellular Matrix, Fluorescence Recovery After Photobleaching, Fluorescence Resonance Energy Transfer, Microscopy, Confocal, Microscopy, Fluorescence, Multiphoton, Molecular Conformation | null |
22,705,212 | 2012-11-30 | 2022-04-08 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | What is the effect of timing of removal on the incidence and severity of complications? | Pogrel M Anthony | eng | null | Comparative Study, Journal Article, Review | null | IM | 22705212, S0278-2391(12)00519-8, 10.1016/j.joms.2012.04.028 | The purpose of this article is to summarize the literature that addresses the following question: "Among patients undergoing third molar removal, do patients who are younger, eg, <25 years, when compared with older patients, have a decreased risk for postoperative complications and more rapid recovery?" | Age Factors, Humans, Molar, Third, Periodontal Diseases, Postoperative Complications, Recovery of Function, Risk Factors, Surgical Wound Infection, Tooth Extraction, Tooth, Impacted, Trigeminal Nerve Injuries, Watchful Waiting | null |
22,705,213 | 2012-11-30 | 2012-08-24 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | How predictable is the position of third molars over time? | Phillips Ceib, White Raymond P | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | null | IM | 22705213, S0278-2391(12)00515-0, 10.1016/j.joms.2012.04.024 | The purpose of this study was to review contemporaneous longitudinal studies focused on changes in the position of third molars. | Asymptomatic Diseases, Forecasting, Humans, Longitudinal Studies, Molar, Third, Tooth Eruption, Tooth, Impacted | null |
22,705,216 | 2013-02-11 | 2022-04-10 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Hypermethylation of p16 tumor-suppressor gene in ameloblastic carcinoma, ameloblastoma, and dental follicles. | Khojasteh Arash, Khodayari Abbas, Rahimi Farzaneh, Ghaderian Mohamad Hossain, Jafarian Mohamad, Nayebi Alireza, Akbarzadeh Najar Reza, Tabatabayipanah Akram, Jahangirnia Alireza | eng | null | Journal Article | null | IM | 22705216, S0278-2391(12)00526-5, 10.1016/j.joms.2012.04.033 | The high rate of p16 gene alterations in malignant neoplasms suggests the important effect of this tumor-suppressor gene mutation on the malignant behavior of tumoral lesions. The present study investigated the possible methylation of the p16 tumor in ameloblastic carcinoma, ameloblastoma, and dental follicles. | Ameloblastoma, CpG Islands, DNA Methylation, Dental Sac, Disease Progression, Female, Genes, p16, Humans, Male, Mandibular Neoplasms, Mutation, Odontogenic Tumors | null |
22,705,214 | 2013-04-08 | 2014-11-20 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | "Twist technique" for pterygomaxillary dysjunction in minimally invasive Le Fort I osteotomy. | Hernández-Alfaro Federico, Guijarro-Martínez Raquel | eng | null | Comparative Study, Journal Article | null | IM | 22705214, S0278-2391(12)00523-X, 10.1016/j.joms.2012.04.032 | To present a new technique for effective, rapid, and safe pterygomaxillary dysjunction in the context of a minimally invasive Le Fort I protocol and to provide the authors' preliminary experience. | Adolescent, Adult, Aged, Child, Female, Humans, Hypesthesia, Male, Maxilla, Maxillary Osteotomy, Maxillary Sinus, Middle Aged, Minimally Invasive Surgical Procedures, Nasal Bone, Nasal Septum, Operative Time, Orbit, Orthognathic Surgical Procedures, Osteotomy, Le Fort, Postoperative Complications, Retrospective Studies, Rotation, Sphenoid Bone, Young Adult | null |
22,705,215 | 2012-11-30 | 2022-04-08 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | What are the risks of operative intervention? | Pogrel M Anthony | eng | null | Journal Article, Review | null | IM | 22705215, S0278-2391(12)00520-4, 10.1016/j.joms.2012.04.029 | The purpose of this article is to conduct a literature review, identify the studies with the highest level of evidence, and summarize the complications associated with operative treatment of impacted third molars (M3s). | Humans, Molar, Third, Periodontal Diseases, Postoperative Complications, Quality of Life, Risk Factors, Temporomandibular Joint Disorders, Tooth, Impacted, Trigeminal Nerve Injuries | null |
22,705,217 | 2013-04-08 | 2016-11-25 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Deep subfascial approach to the temporal area. | Kenkere Deepika, Srinath K S, Reddy Mallika | eng | null | Journal Article | null | IM | 22705217, S0278-2391(12)00510-1, 10.1016/j.joms.2012.04.019 | Surgical access to the temporomandibular joint (TMJ) and zygomatic arch is a challenge even to the experienced maxillofacial surgeon. The conventional subfascial approach to these structures carries the potential risk of transient paralysis of the frontalis and orbicularis oculi muscles. This article discusses the use of a deep subfascial approach to access the TMJ and zygomatic arch. This surgical technique provides a safe operating field without jeopardizing the branches of the facial nerve. | Ankylosis, Arthroplasty, Dermatologic Surgical Procedures, Dissection, Facial Nerve Injuries, Fasciotomy, Humans, Intraoperative Complications, Subcutaneous Tissue, Temporal Muscle, Temporomandibular Joint, Temporomandibular Joint Disorders, Zygoma, Zygomatic Fractures | null |
22,705,222 | 2013-02-11 | 2012-12-18 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | A regressing and metastasizing tumor--the choriocarcinoma. | Bakyalakshmi Karthikeyan, Bharathi Ramakrishnan, Ponniah Irulandy | eng | null | Case Reports, Journal Article | null | IM | 22705222, S0278-2391(12)00402-8, 10.1016/j.joms.2012.03.032 | null | Choriocarcinoma, Fatal Outcome, Female, Gingival Neoplasms, Humans, Liver Neoplasms, Lung Neoplasms, Neoplasm Regression, Spontaneous, Pancreatic Neoplasms, Young Adult | null |
22,705,220 | 2012-12-26 | 2016-11-25 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Bilateral cleft lip: a potential variant form of orofaciodigital syndrome type II? | Liu Yan-Bin, Xing Zhan-kui, Yang Lan, Li Long-jiang, Liu Ying, Liu Xiao-wen | eng | null | Case Reports, Journal Article | null | IM | 22705220, S0278-2391(11)01889-1, 10.1016/j.joms.2011.12.018 | null | Cleft Lip, Humans, Infant, Male, Orofaciodigital Syndromes, Ultrasonography, Prenatal | null |
22,705,219 | 2012-11-30 | 2022-04-09 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Inferior alveolar nerve sensory disturbance after impacted mandibular third molar evaluation using cone beam computed tomography and panoramic radiography: a pilot study. | Guerrero Maria Eugenia, Nackaerts Olivia, Beinsberger Jilke, Horner Keith, Schoenaers Joseph, Jacobs Reinhilde | eng | null | Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | null | IM | 22705219, S0278-2391(12)00505-8, 10.1016/j.joms.2012.04.015 | To measure sensory disturbances of the inferior alveolar nerve (IAN) after removal of impacted mandibular third molars using cone beam computed tomography (CBCT) and dental panoramic radiography (PAN) for preoperative assessment in a randomized controlled trial and to measure the efficacy of the observers' prediction of IAN exposure at surgery based on CBCT compared with PAN. | Chin, Cone-Beam Computed Tomography, Follow-Up Studies, Forecasting, Humans, Lip, Mandibular Nerve, Molar, Third, Patient Care Planning, Pilot Projects, Postoperative Complications, Radiography, Dental, Digital, Radiography, Panoramic, Risk Assessment, Sensory Thresholds, Somatosensory Disorders, Tooth Extraction, Tooth Socket, Tooth, Impacted, Touch, Treatment Outcome, Trigeminal Nerve Injuries | null |
22,705,223 | 2013-02-11 | 2022-03-17 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Unusual bevacizumab-related complication of an oral infection. | Magremanne Michèle, Lahon Morgan, De Ceulaer Joke, Reychler Hervé | eng | null | Case Reports, Journal Article | Angiogenesis Inhibitors, Antibodies, Monoclonal, Humanized, Recombinant Proteins, Bevacizumab | IM | 22705223, S0278-2391(12)00391-6, 10.1016/j.joms.2012.03.022 | null | Angiogenesis Inhibitors, Antibodies, Monoclonal, Humanized, Bevacizumab, Bisphosphonate-Associated Osteonecrosis of the Jaw, Brain Neoplasms, Enterobacter cloacae, Enterobacteriaceae Infections, Face, Fatal Outcome, Glioblastoma, Humans, Male, Mandibular Nerve, Middle Aged, Necrosis, Periodontal Abscess, Recombinant Proteins, Staphylococcal Infections, Surgical Wound Infection, Temporal Lobe | null |
22,705,221 | 2013-02-11 | 2018-12-02 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Maxillofacial metastases: a retrospective review of one institution's 15-year experience. | McClure Shawn A, Movahed Reza, Salama Andrew, Ord Robert A | eng | null | Journal Article, Review | null | IM | 22705221, S0278-2391(12)00443-0, 10.1016/j.joms.2012.04.009 | Metastasis to the maxillofacial region is a rare occurrence. In our retrospective study of patients with metastasis to the maxillofacial region, the subjects were evaluated to define the clinical behavior patterns in response to the treatment given. | Adenocarcinoma, Aged, Aged, 80 and over, Algorithms, Breast Neoplasms, Colonic Neoplasms, Cranial Irradiation, Female, Head and Neck Neoplasms, Hospitals, Special, Humans, Jaw Neoplasms, Lung Neoplasms, Male, Middle Aged, Mouth Neoplasms, Neoplasm Metastasis, Oral Surgical Procedures, Palliative Care, Retrospective Studies, Salivary Gland Neoplasms, Treatment Outcome | null |
22,705,218 | 2013-04-08 | 2013-01-28 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Assessment of blood loss and need for transfusion during bimaxillary surgery with or without maxillary setback. | Choi Bong-Kyoon, Yang Eun-Jung, Oh Kap Sung, Lo Lun-Jou | eng | null | Comparative Study, Journal Article | Hemoglobins | IM | 22705218, S0278-2391(12)00491-0, 10.1016/j.joms.2012.04.012 | The objective of this study was to compare the blood loss, transfusion needs, and operation times in subjects who underwent bimaxillary surgery with versus without maxillary setback. | Adolescent, Adult, Blood Loss, Surgical, Blood Transfusion, Facial Asymmetry, Female, Hemoglobins, Humans, Male, Mandibular Osteotomy, Maxillary Osteotomy, Operative Time, Orthognathic Surgical Procedures, Osteotomy, Le Fort, Osteotomy, Sagittal Split Ramus, Retrospective Studies, Sphenoid Bone, Young Adult | null |
22,705,224 | 2013-02-11 | 2015-11-19 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Effects of hyperbaric oxygen therapy on quality of life in maxillofacial patients with type III osteoradionecrosis. | Harding Sam, Courtney David, Hodder Simon, Bryson Philip | eng | null | Journal Article | null | IM | 22705224, S0278-2391(12)00490-9, 10.1016/j.joms.2012.04.011 | Over a 4-year period, 18 patients with type III osteoradionecrosis that developed an average of 55 months after radiotherapy treatment for head and neck cancers were referred for hyperbaric oxygen therapy (HBO(2)). | Attitude to Health, Dentition, Dyspnea, Eating, Emotions, Feeding and Eating Disorders, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, Hyperbaric Oxygenation, Male, Middle Aged, Osteoradionecrosis, Quality of Life, Range of Motion, Articular, Sleep Initiation and Maintenance Disorders, Social Behavior, Social Environment, Treatment Outcome | null |
22,705,225 | 2013-02-11 | 2022-12-07 | 1531-5053 | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | The folded tunnelized-facial artery myomucosal island flap: a new technique for total soft palate reconstruction. | Massarelli Olindo, Gobbi Roberta, Soma Damiano, Tullio Antonio | eng | null | Case Reports, Journal Article | null | IM | 22705225, S0278-2391(12)00400-4, 10.1016/j.joms.2012.03.030 | null | Aged, Arteries, Carcinoma, Squamous Cell, Humans, Male, Palatal Neoplasms, Palate, Soft, Plastic Surgery Procedures, Surgical Flaps, Uvula | null |
22,705,226 | 2013-04-01 | 2012-11-15 | 1872-8952 | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology | The latency distribution of motor evoked potentials in patients with multiple sclerosis. | Firmin Lea, Müller Samuel, Rösler Kai M | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705226, S1388-2457(12)00408-7, 10.1016/j.clinph.2012.05.008 | To compare the individual latency distributions of motor evoked potentials (MEP) in patients with multiple sclerosis (MS) to the previously reported results in healthy subjects (Firmin et al., 2011). | Adult, Case-Control Studies, Efferent Pathways, Evoked Potentials, Motor, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Neural Conduction, Peripheral Nerves, Reaction Time, Time Factors, Transcranial Magnetic Stimulation | null |
22,705,227 | 2013-04-01 | 2019-12-10 | 1872-8952 | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology | Automated single-trial assessment of laser-evoked potentials as an objective functional diagnostic tool for the nociceptive system. | Hatem S M, Hu L, Ragé M, Gierasimowicz A, Plaghki L, Bouhassira D, Attal N, Iannetti G D, Mouraux A | eng | null | Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705227, S1388-2457(12)00405-1, 10.1016/j.clinph.2012.05.007 | To assess the clinical usefulness of an automated analysis of event-related potentials (ERPs). | Adult, Case-Control Studies, Electroencephalography, Evidence-Based Medicine, Evoked Potentials, Evoked Potentials, Somatosensory, Female, Humans, Lasers, Linear Models, Male, Middle Aged, Nociceptors, Observer Variation, Reaction Time, Reproducibility of Results, Sensitivity and Specificity, Syringomyelia | null |
22,705,228 | 2013-01-08 | 2012-08-24 | 1879-0070 | Diagnostic microbiology and infectious disease | Streptococcus suis infection in Taiwan, 2000-2011. | Tsai Hsih-Yeh, Liao Chun-Hsing, Liu Chia-Ying, Huang Yu-Tsung, Teng Lee-Jene, Hsueh Po-Ren | eng | null | Journal Article | DNA, Bacterial, DNA, Ribosomal, RNA, Ribosomal, 16S | IM | 22705228, S0732-8893(12)00195-2, 10.1016/j.diagmicrobio.2012.05.013 | From 2000 to 2011, 8 patients with Streptococcus suis infections were identified in Taiwan. Six isolates were initially misidentified as Streptococcus acidominimus using commercial identification systems and later confirmed to be S. suis using 16S rRNA gene sequencing analysis. Among the 7 isolates available for further analysis, all belonged to biotype II. Three serotype I isolates possessed the same genotypes, indicating the possible clonal spread of S. suis. All of these patients survived. S. suis infection is underestimated in Taiwan. | Adult, Aged, Bacterial Typing Techniques, Cluster Analysis, DNA, Bacterial, DNA, Ribosomal, Female, Genotype, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Molecular Typing, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Streptococcal Infections, Streptococcus suis, Taiwan | null |
22,705,230 | 2013-04-29 | 2018-12-02 | 0035-3787 | Revue neurologique | [Impact of drug-free care in posterior cortical atrophy: Preliminary experience with a psycho-educative program]. | Videaud H, Torny F, Cartz-Piver L, Deschamps-Vergara N, Couratier P | fre | null | Clinical Trial, Journal Article | Pharmaceutical Preparations | IM | 22705230, S0035-3787(12)00784-9, 10.1016/j.neurol.2011.10.013 | Criteria for the diagnosis of posterior cortical atrophy (PCA) are well established, but little is known about the impact of drug-free care for patients and caregivers. | Aged, Atrophy, Brain, Caregivers, Cognitive Behavioral Therapy, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Neurodegenerative Diseases, Patient Education as Topic, Pharmaceutical Preparations, Pilot Projects, Quality of Life, Syndrome | null |
22,705,231 | 2013-04-29 | 2016-11-25 | 0035-3787 | Revue neurologique | [Peripheral neurosarcoidosis and chronic C hepatitis: Responsibility of antiviral therapies]. | Assenova M, Sacko A, Cadranel J-F, Logak M | fre | null | Case Reports, Letter | Antiviral Agents | IM | 22705231, S0035-3787(12)00803-X, 10.1016/j.neurol.2011.11.011 | null | Antiviral Agents, Central Nervous System Diseases, Chemical and Drug Induced Liver Injury, Female, Guillain-Barre Syndrome, Hepatitis C, Chronic, Humans, Middle Aged, Peripheral Nervous System Diseases, Sarcoidosis | null |
22,705,233 | 2013-09-03 | 2022-03-30 | 2212-4411 | Oral surgery, oral medicine, oral pathology and oral radiology | Prognostic factors for autotransplantation of teeth with complete root formation. | Aoyama Shoko, Yoshizawa Michiko, Niimi Kanae, Sugai Toshiko, Kitamura Nobutaka, Saito Chikara | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22705233, S2212-4403(12)00165-4, 10.1016/j.oooo.2011.09.037 | The aim of the present study was to evaluate the factors affecting the prognosis of the autotransplantation of teeth with complete root formation. | Adolescent, Adult, Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Prognosis, Radiography, Risk, Tooth, Tooth Root, Transplantation, Autologous, Treatment Failure | null |
22,705,232 | 2013-01-24 | 2024-11-27 | 1879-0631 | Life sciences | Nicotinic receptor and tobacco-related cancer. | Russo Patrizia, Cardinale Alessio, Margaritora Stefano, Cesario Alfredo | eng | null | Journal Article, Review | Receptors, Nicotinic, Nicotine | IM | 22705232, S0024-3205(12)00262-7, 10.1016/j.lfs.2012.05.003 | Currently, tobacco smoking causes approximately 5-6 million deaths per year including more than 35% of all cancer deaths. Nicotine, the addictive constituent of tobacco, and its derived carcinogenic nitrosamines, contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChR). Although the role of nicotine in cancerogenesis is still discussed controversially, it has been recently shown that nicotine induces DNA damages, via induction of oxidative stress, in bronchial epithelial cells. Moreover, nicotine is able to induce muscle sarcomas in A/J mice. In this mini-review we highlight the role of nAChR and nicotine in all cancer phases (induction, promotion and progression). Relevant new findings quoted in literature and some new experiments of our laboratory were reported and discussed. | Animals, Humans, Lung Neoplasms, Neoplasms, Nicotine, Polymorphism, Single Nucleotide, Receptors, Nicotinic, Tobacco Products | null |
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