diff --git "a/PLOD-CW-25-Train.conll" "b/PLOD-CW-25-Train.conll"
new file mode 100644--- /dev/null
+++ "b/PLOD-CW-25-Train.conll"
@@ -0,0 +1,84548 @@
+MRR NOUN B-AC
+, PUNCT O
+mortality NOUN B-LF
+rate NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+TBI PROPN B-AC
+, PUNCT O
+traumatic ADJ B-LF
+brain NOUN I-LF
+injury NOUN I-LF
+. PUNCT O
+
+HPC PROPN B-AC
+, PUNCT O
+hippocampus NOUN B-LF
+; PUNCT O
+mOFC NOUN O
+, PUNCT O
+medial ADJ O
+OFC PROPN B-AC
+; PUNCT O
+OFC PROPN B-AC
+, PUNCT O
+orbitofrontal ADJ B-LF
+cortex NOUN I-LF
+; PUNCT O
+PPI NOUN B-AC
+, PUNCT O
+psychophysiological ADJ B-LF
+interaction NOUN I-LF
+. PUNCT O
+
+In ADP O
+addition NOUN O
+to ADP O
+the DET O
+effects NOUN O
+on ADP O
+cell NOUN O
+growth NOUN O
+and CCONJ O
+migration NOUN O
+, PUNCT O
+the DET O
+18β NOUN B-AC
+- PUNCT B-AC
+GA NOUN B-AC
+- PUNCT B-AC
+d NOUN B-AC
+used VERB O
+in ADP O
+this DET O
+study NOUN O
+could AUX O
+also ADV O
+up ADV O
+- PUNCT O
+regulate VERB O
+expression NOUN O
+of ADP O
+aquaporin-3 NOUN B-LF
+( PUNCT O
+AQP-3 NOUN B-AC
+) PUNCT O
+in ADP O
+fibroblasts NOUN O
+and CCONJ O
+keratinocytes NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+HC PROPN B-AC
+, PUNCT O
+C NOUN B-LF
+- PUNCT I-LF
+terminal ADJ I-LF
+receptor NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+domain NOUN I-LF
+; PUNCT O
+ka NOUN B-AC
+, PUNCT O
+association NOUN B-LF
+rate NOUN I-LF
+constant ADJ I-LF
+; PUNCT O
+kd NOUN B-AC
+, PUNCT O
+dissociation NOUN B-LF
+rate NOUN I-LF
+constant ADJ I-LF
+; PUNCT O
+KD NOUN B-AC
+, PUNCT O
+equilibrium NOUN B-LF
+dissociation NOUN I-LF
+constant ADJ I-LF
+; PUNCT O
+ND PROPN B-AC
+, PUNCT O
+nanodisc NOUN B-LF
+; PUNCT O
+Syt PROPN B-AC
+, PUNCT O
+synaptotagmin NOUN B-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+
+LL PROPN B-AC
+: PUNCT O
+lower ADJ B-LF
+limit NOUN I-LF
+, PUNCT O
+UL PROPN B-AC
+: PUNCT O
+upper ADJ B-LF
+limit NOUN I-LF
+. PUNCT O
+
+Transcriptome NOUN O
+analysis NOUN O
+revealed VERB O
+up NOUN O
+- PUNCT O
+regulation NOUN O
+of ADP O
+G1 PROPN O
+/ SYM O
+S PROPN O
+phase NOUN O
+transition NOUN O
+genes NOUN O
+( PUNCT O
+myelocytomatosis NOUN B-LF
+oncogene NOUN I-LF
+cellular ADJ I-LF
+homolog NOUN I-LF
+[ PUNCT O
+Myc PROPN B-AC
+] PUNCT O
+, PUNCT O
+cyclin NOUN O
+D1/3 PROPN O
+, PUNCT O
+chromatin NOUN B-LF
+licensing NOUN I-LF
+and CCONJ I-LF
+DNA NOUN I-LF
+replication NOUN I-LF
+factor NOUN I-LF
+1 NUM I-LF
+[ PUNCT O
+Cdt1 PROPN B-AC
+] PUNCT O
+) PUNCT O
+, PUNCT O
+concomitant ADJ O
+with ADP O
+increased VERB O
+phosphorylation NOUN O
+of ADP O
+the DET O
+retinoblastoma NOUN B-LF
+( PUNCT O
+RB PROPN B-AC
+) PUNCT O
+protein NOUN O
+by ADP O
+cyclin NOUN O
+- PUNCT O
+dependent ADJ O
+kinase NOUN O
+( PUNCT O
+CDK PROPN B-AC
+) PUNCT O
+4/6 NUM O
+and CCONJ O
+increased VERB O
+G1 PROPN O
+- PUNCT O
+S PROPN O
+progression NOUN O
+. PUNCT O
+
+Functional ADJ O
+status NOUN O
+was AUX O
+measured VERB O
+using VERB O
+the DET O
+validated VERB O
+MDS PROPN B-AC
+- PUNCT O
+ADL PROPN B-AC
+scale NOUN O
+, PUNCT O
+which PRON O
+aggregates VERB O
+7 NUM O
+activities NOUN B-LF
+of ADP I-LF
+daily ADJ I-LF
+living NOUN I-LF
+( PUNCT O
+ADL PROPN B-AC
+) PUNCT O
+items NOUN O
+into ADP O
+a DET O
+28 NUM O
+- PUNCT O
+point NOUN O
+scale NOUN O
+with ADP O
+0 NUM O
+indicating VERB O
+independence NOUN O
+and CCONJ O
+28 NUM O
+indicating VERB O
+total ADJ O
+dependence NOUN O
+[ PUNCT O
+18,19 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+screened VERB O
+primary ADJ O
+RNA NOUN O
+samples NOUN O
+from ADP O
+human ADJ O
+blood NOUN O
+, PUNCT O
+colon NOUN O
+, PUNCT O
+placenta NOUN O
+, PUNCT O
+and CCONJ O
+testis NOUN O
+by ADP O
+5′ NUM O
+rapid ADJ B-LF
+amplification NOUN I-LF
+of ADP I-LF
+cDNA NOUN I-LF
+ends NOUN I-LF
+( PUNCT O
+RACE NOUN B-AC
+) PUNCT O
+and CCONJ O
+could AUX O
+not PART O
+confirm VERB O
+this DET O
+TSS NOUN B-AC
+in ADP O
+these DET O
+tissues NOUN O
+. PUNCT O
+
+n NOUN O
+, PUNCT O
+number NOUN O
+of ADP O
+patients NOUN O
+in ADP O
+subgroup NOUN O
+of ADP O
+interest NOUN O
+. PUNCT O
+aOR PROPN B-AC
+, PUNCT O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratios NOUN I-LF
+— PUNCT O
+adjustment NOUN O
+described VERB O
+in ADP O
+footnotes NOUN O
+for ADP O
+Table NOUN O
+3 NUM O
+. PUNCT O
+
+The DET O
+proteins NOUN O
+Raptor PROPN O
+and CCONJ O
+Rictor PROPN B-AC
+( PUNCT O
+rapamycin NOUN B-LF
+- ADJ I-LF
+insensitive ADJ I-LF
+companion NOUN I-LF
+of ADP I-LF
+mTOR PROPN I-LF
+) PUNCT O
+are AUX O
+mutually ADV O
+- ADJ O
+exclusive ADJ O
+binding VERB O
+partners NOUN O
+for ADP O
+TOR PROPN B-AC
+and CCONJ O
+define VERB O
+the DET O
+TORC1 NOUN O
+and CCONJ O
+TORC2 PROPN O
+complexes NOUN O
+, PUNCT O
+respectively ADV O
+[ X O
+3 NUM O
+] PUNCT O
+. PUNCT O
+
+It PRON O
+is AUX O
+quite ADV O
+plausible ADJ O
+that SCONJ O
+AMPK PROPN B-AC
+cooperates VERB O
+with ADP O
+FOrkhead PROPN B-LF
+boX PROPN I-LF
+O PROPN I-LF
+( PUNCT O
+FOXO)/DAF-16 PROPN B-AC
+to PART O
+maintain VERB O
+this DET O
+state NOUN O
+throughout ADP O
+the DET O
+diapause NOUN O
+and/or CCONJ O
+in ADP O
+other ADJ O
+situations NOUN O
+of ADP O
+energy NOUN O
+stress NOUN O
+. PUNCT O
+
+Full ADJ O
+model NOUN O
+( PUNCT O
+red ADJ O
+curve NOUN O
+) PUNCT O
+includes VERB O
+the DET O
+diabetes NOUN O
+risk NOUN O
+score NOUN O
+, PUNCT O
+FPG PROPN B-AC
+, PUNCT O
+A1C PROPN O
+and CCONJ O
+FLI NOUN B-AC
+. PUNCT O
+The DET O
+blue ADJ O
+curves NOUN O
+correspond VERB O
+to ADP O
+the DET O
+same ADJ O
+model NOUN O
+after ADP O
+the DET O
+exclusion NOUN O
+of ADP O
+one NUM O
+of ADP O
+the DET O
+components NOUN O
+: PUNCT O
+diabetes NOUN O
+risk NOUN O
+score NOUN O
+( PUNCT O
+A NOUN O
+) PUNCT O
+, PUNCT O
+FPG PROPN B-AC
+( PUNCT O
+B NOUN O
+) PUNCT O
+, PUNCT O
+A1C PROPN O
+( PUNCT O
+C NOUN O
+) PUNCT O
+and CCONJ O
+FLI NOUN B-AC
+( PUNCT O
+D NOUN O
+) PUNCT O
+. PUNCT O
+FLI NOUN B-AC
+: PUNCT O
+fatty ADJ B-LF
+liver NOUN I-LF
+index NOUN I-LF
+. PUNCT O
+
+Insets NOUN O
+show VERB O
+representative ADJ O
+examples NOUN O
+of ADP O
+RFP NOUN O
+- PUNCT O
+positive ADJ O
+nuclei NOUN O
+( PUNCT O
+outlined VERB O
+by ADP O
+dashed VERB O
+yellow ADJ O
+lines NOUN O
+) PUNCT O
+that PRON O
+are AUX O
+either CCONJ O
+Ki67 NOUN O
+- PUNCT O
+positive ADJ O
+( PUNCT O
+yellow ADJ O
+arrows NOUN O
+, PUNCT O
+see VERB O
+also ADV O
+main ADJ O
+panels NOUN O
+) PUNCT O
+or CCONJ O
+- PUNCT O
+negative ADJ O
+( PUNCT O
+yellow ADJ O
+arrowheads NOUN O
+) PUNCT O
+; PUNCT O
+scale NOUN O
+bars NOUN O
+, PUNCT O
+5 NUM O
+μm NOUN O
+. PUNCT O
+( PUNCT O
+K NOUN O
+) PUNCT O
+Quantification NOUN O
+of ADP O
+Ki67- NOUN O
+and CCONJ O
+RFP NOUN O
+- PUNCT O
+positive ADJ O
+cells NOUN O
+in ADP O
+the DET O
+cortical ADJ O
+wall NOUN O
+( PUNCT O
+total ADJ O
+) PUNCT O
+, PUNCT O
+VZ PROPN B-AC
+and CCONJ O
+SVZ PROPN B-AC
+, PUNCT O
+expressed VERB O
+as ADP O
+percentage NOUN O
+of ADP O
+all DET O
+RFP NOUN O
+- PUNCT O
+positive ADJ O
+cells NOUN O
+in ADP O
+the DET O
+cortical ADJ O
+wall NOUN O
+( PUNCT O
+200 NUM O
+- PUNCT O
+μm NOUN O
+wide ADJ O
+area NOUN O
+) PUNCT O
+, PUNCT O
+upon SCONJ O
+control NOUN O
+( PUNCT O
+Con PROPN O
+, PUNCT O
+white ADJ O
+) PUNCT O
+and CCONJ O
+Pax6 PROPN O
+( PUNCT O
+black ADJ O
+) PUNCT O
+electroporation NOUN O
+. PUNCT O
+( PUNCT O
+E PROPN O
+, PUNCT O
+G PROPN O
+, PUNCT O
+H NOUN O
+, PUNCT O
+K NOUN O
+) PUNCT O
+Mean NOUN O
+of ADP O
+nine NUM O
+embryos NOUN O
+( PUNCT O
+three NUM O
+independent ADJ O
+experiments NOUN O
+with ADP O
+three NUM O
+embryos NOUN O
+each PRON O
+) PUNCT O
+; PUNCT O
+error NOUN O
+bars NOUN O
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+( PUNCT O
+SEM PROPN B-AC
+) PUNCT O
+. PUNCT O
+* PUNCT O
+p NOUN O
+< X O
+0.05 NUM O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< X O
+0.01 NUM O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< X O
+0.001 NUM O
+. PUNCT O
+
+HbA1c NOUN B-AC
+, PUNCT O
+glycated ADJ B-LF
+haemoglobin NOUN I-LF
+; PUNCT O
+HOMA PROPN B-AC
+- PUNCT B-AC
+B PROPN B-AC
+, PUNCT O
+homeostatic ADJ B-LF
+model NOUN I-LF
+assessment NOUN I-LF
+of ADP I-LF
+beta NOUN I-LF
+cell NOUN I-LF
+function NOUN I-LF
+; PUNCT O
+HOMA PROPN B-AC
+- PUNCT B-AC
+IR PROPN B-AC
+, PUNCT O
+homeostatic ADJ B-LF
+model NOUN I-LF
+assessment NOUN I-LF
+of ADP I-LF
+insulin NOUN I-LF
+resistance NOUN I-LF
+. PUNCT O
+
+A DET O
+major ADJ O
+goal NOUN O
+of ADP O
+quantitative ADJ O
+immunology NOUN O
+is AUX O
+to PART O
+be AUX O
+able ADJ O
+to PART O
+detect VERB O
+and CCONJ O
+predict VERB O
+T PROPN B-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+TCR NOUN B-AC
+) PUNCT O
+specificity NOUN O
+from ADP O
+high ADJ B-LF
+- PUNCT I-LF
+throughput NOUN I-LF
+sequencing NOUN I-LF
+of ADP I-LF
+TCR NOUN I-LF
+repertoires NOUN I-LF
+( PUNCT O
+RepSeq PROPN B-AC
+) PUNCT O
+data NOUN O
+. PUNCT O
+
+We PRON O
+evaluated VERB O
+the DET O
+association NOUN O
+between ADP O
+drought NOUN O
+at ADP O
+the DET O
+date NOUN O
+of ADP O
+birth NOUN O
+and CCONJ O
+receipt NOUN O
+of ADP O
+bacillus NOUN B-LF
+Calmette PROPN I-LF
+– PUNCT I-LF
+Guérin PROPN I-LF
+( PUNCT O
+BCG PROPN B-AC
+) PUNCT O
+, PUNCT O
+diphtheria NOUN B-LF
+– PUNCT I-LF
+pertussis NOUN I-LF
+– PUNCT I-LF
+tetanus NOUN I-LF
+( PUNCT O
+DPT PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+polio NOUN O
+vaccinations NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+association NOUN O
+between ADP O
+drought NOUN O
+at ADP O
+12 NUM O
+months NOUN O
+of ADP O
+age NOUN O
+and CCONJ O
+receipt NOUN O
+of ADP O
+measles NOUN O
+vaccination NOUN O
+. PUNCT O
+
+Therefore ADV O
+, PUNCT O
+in ADP O
+this DET O
+study NOUN O
+we PRON O
+have AUX O
+created VERB O
+a DET O
+vaccine NOUN O
+delivery NOUN O
+platform NOUN O
+for ADP O
+synthetic ADJ O
+minimal ADJ O
+immunogens NOUN O
+that PRON O
+would AUX O
+improve VERB O
+their PRON O
+immunogenicity NOUN O
+and CCONJ O
+can AUX O
+be AUX O
+linked VERB O
+directly ADV O
+to ADP O
+potent ADJ O
+Toll PROPN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptor NOUN I-LF
+( PUNCT O
+TLR PROPN B-AC
+) PUNCT O
+7/8 NUM O
+agonist NOUN O
+adjuvants NOUN O
+[ PUNCT O
+35 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+Cochrane PROPN O
+’s PART O
+Q NOUN O
+- NOUN O
+test NOUN O
+was AUX O
+performed VERB O
+and CCONJ O
+I2 PROPN O
+statistics NOUN O
+were AUX O
+obtained VERB O
+, PUNCT O
+using VERB O
+a DET O
+predefined VERB O
+significance NOUN O
+threshold NOUN O
+of ADP O
+0.05.If NUM O
+P≥0.05 NUM O
+, PUNCT O
+it PRON O
+was AUX O
+considered VERB O
+that SCONJ O
+there PRON O
+was AUX O
+no DET O
+heterogeneity NOUN O
+between ADP O
+studies NOUN O
+; PUNCT O
+and CCONJ O
+a DET O
+fixed ADJ B-LF
+effects NOUN I-LF
+model NOUN I-LF
+( PUNCT O
+FEM PROPN B-AC
+) PUNCT O
+was AUX O
+used VERB O
+for ADP O
+the DET O
+analysis NOUN O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+NA PROPN O
+, PUNCT O
+not PART O
+adopted VERB O
+; PUNCT O
+NS PROPN O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+ALBI PROPN B-AC
+, PUNCT O
+Albumin PROPN B-LF
+- PUNCT I-LF
+Bilirubin PROPN I-LF
+. PUNCT O
+
+On ADP O
+the DET O
+other ADJ O
+hand NOUN O
+, PUNCT O
+A NOUN B-AC
+- PUNCT B-AC
+to ADP B-AC
+- PUNCT B-AC
+I NOUN B-AC
+RNA NOUN B-AC
+editing NOUN B-AC
+is AUX O
+catalyzed VERB O
+by ADP O
+adenosine NOUN B-LF
+deaminase NOUN I-LF
+acting VERB I-LF
+on ADP I-LF
+RNA NOUN I-LF
+( PUNCT O
+ADAR PROPN B-AC
+) PUNCT O
+enzymes NOUN O
+, PUNCT O
+ADAR1 PROPN O
+and CCONJ O
+ADAR2 PROPN O
+, PUNCT O
+that PRON O
+specifically ADV O
+bind VERB O
+to ADP O
+double ADJ B-LF
+- PUNCT I-LF
+stranded ADJ I-LF
+RNA NOUN I-LF
+( PUNCT O
+dsRNA NOUN B-AC
+) PUNCT O
+[ PUNCT O
+17,18 NUM O
+] PUNCT O
+. PUNCT O
+
+OR PROPN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+Lapa PROPN O
+, PUNCT O
+laparoscopy NOUN O
+; PUNCT O
+CRT PROPN B-AC
+, PUNCT O
+chemoradiotherapy NOUN B-LF
+. PUNCT O
+
+The DET O
+definition NOUN O
+of ADP O
+an DET O
+iMotif PROPN B-AC
+depends VERB O
+on ADP O
+the DET O
+minimum ADJ O
+number NOUN O
+of ADP O
+common ADJ O
+partners NOUN O
+required VERB O
+in ADP O
+order NOUN O
+to PART O
+consider VERB O
+the DET O
+given VERB O
+binary ADJ O
+protein NOUN O
+interactions NOUN O
+mediated VERB O
+through ADP O
+a DET O
+common ADJ O
+interacting VERB B-LF
+motif NOUN I-LF
+. PUNCT O
+
+All DET O
+the DET O
+genes NOUN O
+in ADP O
+the DET O
+pathway NOUN O
+are AUX O
+known VERB O
+to ADP O
+be AUX O
+coregulated VERB O
+by ADP O
+the DET O
+same ADJ O
+transcription NOUN O
+factors NOUN O
+, PUNCT O
+but CCONJ O
+we PRON O
+observed VERB O
+drastically ADV O
+different ADJ O
+dynamic ADJ O
+responses NOUN O
+for ADP O
+enzymes NOUN O
+upstream ADJ O
+and CCONJ O
+immediately ADV O
+downstream ADJ O
+of ADP O
+the DET O
+key ADJ O
+control NOUN O
+point NOUN O
+— PUNCT O
+the DET O
+intermediate ADJ O
+metabolite NOUN O
+α NOUN B-LF
+- NOUN I-LF
+isopropylmalate NOUN I-LF
+( PUNCT O
+αIPM PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+couples VERB O
+metabolic ADJ O
+activity NOUN O
+to ADP O
+transcriptional ADJ O
+regulation NOUN O
+. PUNCT O
+
+An DET O
+interesting ADJ O
+finding NOUN O
+during ADP O
+this PRON O
+study NOUN O
+was AUX O
+that SCONJ O
+a DET O
+higher ADJ O
+dose NOUN O
+of ADP O
+LA PROPN B-AC
+( PUNCT O
+10 NUM O
+μM NOUN O
+) PUNCT O
+did AUX O
+not PART O
+elicit VERB O
+a DET O
+recovery NOUN O
+response NOUN O
+as ADP O
+compared VERB O
+to ADP O
+1 NUM O
+μM NOUN O
+of ADP O
+LA PROPN B-AC
+. PUNCT O
+One NUM O
+explanation NOUN O
+for ADP O
+this PRON O
+is AUX O
+that SCONJ O
+LA PROPN B-AC
+at ADP O
+higher ADJ O
+doses NOUN O
+is AUX O
+fragmented VERB O
+into ADP O
+smaller ADJ O
+peptide NOUN O
+fragments NOUN O
+that SCONJ O
+inhibit VERB O
+the DET O
+reparative ADJ O
+effects NOUN O
+of ADP O
+LA PROPN B-AC
+. PUNCT O
+Indeed ADV O
+, PUNCT O
+analysis NOUN O
+of ADP O
+the DET O
+bathing NOUN O
+solution NOUN O
+containing VERB O
+LA PROPN B-AC
+revealed VERB O
+at ADP O
+least ADV O
+4 NUM O
+fragments NOUN O
+of ADP O
+LA PROPN B-AC
+were AUX O
+present ADJ O
+, PUNCT O
+and CCONJ O
+application NOUN O
+of ADP O
+a DET O
+higher ADJ O
+dose NOUN O
+of ADP O
+F2 PROPN B-AC
+( PUNCT O
+10 NUM O
+μM NOUN O
+) PUNCT O
+in ADP O
+particular ADJ O
+inhibited VERB O
+the DET O
+recovery NOUN O
+response NOUN O
+induced VERB O
+by ADP O
+LA PROPN B-AC
+. PUNCT O
+We PRON O
+also ADV O
+determined VERB O
+that SCONJ O
+F1 PROPN B-AC
+and CCONJ O
+F2 PROPN B-AC
+are AUX O
+formed VERB O
+by ADP O
+the DET O
+brush NOUN O
+border NOUN O
+enzyme NOUN O
+aminopeptidase NOUN B-LF
+M PROPN I-LF
+when SCONJ O
+AM PROPN B-AC
+was AUX O
+incubated VERB O
+with ADP O
+LA PROPN B-AC
+in ADP O
+vitro ADV O
+. PUNCT O
+
+A DET O
+forward ADJ O
+genetic ADJ O
+screen NOUN O
+for ADP O
+immunocompromised ADJ O
+mutants NOUN O
+demonstrated VERB O
+a DET O
+requirement NOUN O
+for ADP O
+a DET O
+conserved VERB O
+p38 NOUN O
+mitogen NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT O
+MAPK PROPN B-AC
+) PUNCT O
+pathway NOUN O
+in ADP O
+C. PROPN O
+elegans NOUN O
+immunity NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+H. PROPN O
+dujardini PROPN O
+had VERB O
+40 NUM O
+UDP PROPN B-AC
+glycosyltransferase NOUN O
+genes NOUN O
+, PUNCT O
+29 NUM O
+of ADP O
+which PRON O
+were AUX O
+classified VERB O
+as ADP O
+glucuronosyltransferase NOUN O
+( PUNCT O
+UGT PROPN B-AC
+, PUNCT O
+K00699 NOUN O
+) PUNCT O
+by ADP O
+Kyoto PROPN B-LF
+Encyclopedia PROPN I-LF
+of ADP I-LF
+Genes PROPN I-LF
+and CCONJ I-LF
+Genomes PROPN I-LF
+( PUNCT O
+KEGG PROPN B-AC
+) PUNCT O
+ORTHOLOG PROPN O
+mapping NOUN O
+with ADP O
+the DET O
+KEGG PROPN B-LF
+Automatic PROPN I-LF
+Annotation PROPN I-LF
+Server PROPN I-LF
+( PUNCT O
+KAAS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+70 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+of ADP O
+these DET O
+27 NUM O
+were AUX O
+HGT PROPN B-AC
+candidates NOUN O
+. PUNCT O
+
+ALT PROPN B-AC
+: PUNCT O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+, PUNCT O
+AST PROPN B-AC
+: PUNCT O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+, PUNCT O
+HDL NOUN O
+- PUNCT O
+C PROPN O
+: PUNCT O
+high ADJ O
+- PUNCT O
+density NOUN O
+lipoprotein NOUN O
+cholesterol NOUN O
+, PUNCT O
+HFD NOUN B-AC
+: PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+, PUNCT O
+LDL NOUN O
+- PUNCT O
+C PROPN O
+: PUNCT O
+low ADJ O
+- PUNCT O
+density NOUN O
+lipoprotein NOUN O
+cholesterol NOUN O
+, PUNCT O
+VLDL NOUN O
+- PUNCT O
+C PROPN O
+: PUNCT O
+very ADV O
+- PUNCT O
+low ADJ O
+- PUNCT O
+density NOUN O
+lipoprotein NOUN O
+cholesterol NOUN O
+. PUNCT O
+
+( PUNCT O
+A X O
+) PUNCT O
+Mouse NOUN B-LF
+brain NOUN I-LF
+capillary ADJ I-LF
+endothelial ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+mBECs NOUN B-AC
+) PUNCT O
+are AUX O
+isolated VERB O
+on ADP O
+day NOUN O
+-4 NUM O
+, PUNCT O
+while SCONJ O
+both CCONJ O
+rat NOUN O
+BECs NOUN B-AC
+( PUNCT O
+rBECs NOUN B-AC
+) PUNCT O
+and CCONJ O
+porcine NOUN O
+BECs NOUN B-AC
+( PUNCT O
+pBECs NOUN B-AC
+) PUNCT O
+are AUX O
+isolated VERB O
+on ADP O
+day NOUN O
+-3 NUM O
+. PUNCT O
+
+In ADP O
+Ube3A PROPN O
+deficient ADJ O
+mice NOUN O
+, PUNCT O
+the DET O
+BDNF PROPN B-AC
+- PUNCT O
+induced VERB O
+recruitment NOUN O
+of ADP O
+PSD-95 PROPN B-AC
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+PLCγ NOUN O
+and CCONJ O
+Grb2 PROPN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+binder NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+Gab1 PROPN B-AC
+) PUNCT O
+with ADP O
+TrkB PROPN O
+receptors NOUN O
+was AUX O
+attenuated VERB O
+, PUNCT O
+resulting VERB O
+in ADP O
+reduced VERB O
+activation NOUN O
+of ADP O
+PLCγ NOUN O
+- PUNCT O
+α NOUN B-LF
+- PUNCT I-LF
+calcium NOUN I-LF
+/ SYM I-LF
+calmodulin NOUN I-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+II PROPN I-LF
+( PUNCT O
+CaMKII PROPN B-AC
+) PUNCT O
+and CCONJ O
+PI3K PROPN O
+- PUNCT O
+Akt PROPN O
+, PUNCT O
+but CCONJ O
+leaving VERB O
+the DET O
+extracellular ADJ O
+signal NOUN O
+- PUNCT O
+regulated VERB O
+kinase NOUN O
+( PUNCT O
+Erk PROPN O
+) PUNCT O
+pathway NOUN O
+intact ADJ O
+. PUNCT O
+
+AHR NOUN B-AC
+: PUNCT O
+Adjusted VERB B-LF
+Hazard NOUN I-LF
+Ratio NOUN I-LF
+; PUNCT O
+ART NOUN B-AC
+: PUNCT O
+Antiretroviral ADJ B-LF
+Therapy PROPN I-LF
+; PUNCT O
+CHR NOUN B-AC
+: PUNCT O
+Crude ADJ B-LF
+Hazard NOUN I-LF
+Ratio NOUN I-LF
+; PUNCT O
+CI NOUN O
+: PUNCT O
+Confidence NOUN O
+Interval NOUN O
+; PUNCT O
+CPT NOUN B-AC
+: PUNCT O
+Cotrimoxazole PROPN O
+Preventive PROPN O
+Therapy PROPN O
+; PUNCT O
+IPT PROPN B-AC
+: PUNCT O
+Isoniazid PROPN O
+Prophylactic PROPN O
+Therapy PROPN O
+; PUNCT O
+TB NOUN O
+: PUNCT O
+Tuberculosis NOUN O
+
+Bladder NOUN O
+pain NOUN O
+commonly ADV O
+occurs VERB O
+without ADP O
+obvious ADJ O
+bladder NOUN O
+pathology NOUN O
+and CCONJ O
+is AUX O
+a DET O
+cardinal ADJ O
+symptom NOUN O
+of ADP O
+interstitial ADJ B-LF
+cystitis NOUN I-LF
+/ SYM I-LF
+painful ADJ I-LF
+bladder NOUN I-LF
+syndrome NOUN I-LF
+( PUNCT O
+IC PROPN B-AC
+/ SYM B-AC
+PBS PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+chronic ADJ O
+condition NOUN O
+with ADP O
+unknown ADJ O
+etiology NOUN O
+affecting VERB O
+2.7–6.5 NUM O
+% NOUN O
+of ADP O
+women NOUN O
+in ADP O
+the DET O
+U.S. PROPN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+NNRTI PROPN B-AC
+, PUNCT O
+non ADJ B-LF
+- ADJ I-LF
+nucleoside NOUN I-LF
+reverse ADJ I-LF
+transcriptase NOUN I-LF
+inhibitor NOUN I-LF
+; PUNCT O
+NRTI PROPN B-AC
+, PUNCT O
+nucleoside NOUN B-LF
+reverse ADJ I-LF
+transcriptase NOUN I-LF
+inhibitor NOUN I-LF
+; PUNCT O
+VL PROPN B-AC
+, PUNCT O
+viral ADJ B-LF
+load NOUN I-LF
+. PUNCT O
+
+CHW PROPN B-AC
+, PUNCT O
+community NOUN B-LF
+health NOUN I-LF
+worker NOUN I-LF
+; PUNCT O
+HF PROPN B-AC
+, PUNCT O
+health NOUN B-LF
+facility NOUN I-LF
+; PUNCT O
+RRS PROPN B-AC
+, PUNCT O
+rapid ADJ B-LF
+reporting NOUN I-LF
+system NOUN I-LF
+. PUNCT O
+
+Phosphorylated VERB O
+LuxO PROPN O
+activates VERB O
+the DET O
+transcription NOUN O
+of ADP O
+the DET O
+genes NOUN O
+encoding VERB O
+the DET O
+small ADJ B-LF
+RNAs NOUN I-LF
+( PUNCT O
+sRNAs NOUN B-AC
+) PUNCT O
+Qrr1 PROPN O
+- ADV O
+4 NUM O
+, PUNCT O
+which PRON O
+in ADP O
+turn NOUN O
+post ADV O
+- ADV O
+transcriptionally ADV O
+activate VERB O
+AphA PROPN O
+and CCONJ O
+repress VERB O
+HapR. PROPN O
+
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild NOUN B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+A DET O
+more ADV O
+neurophysiologically ADV O
+grounded ADJ O
+interpretation NOUN O
+of ADP O
+the DET O
+MMN PROPN B-AC
+, PUNCT O
+known VERB O
+as ADP O
+the DET O
+adaptation NOUN O
+hypothesis NOUN O
+, PUNCT O
+denies VERB O
+the DET O
+existence NOUN O
+of ADP O
+a DET O
+genuine ADJ O
+process NOUN O
+of ADP O
+deviance NOUN O
+detection NOUN O
+, PUNCT O
+arguing VERB O
+that SCONJ O
+the DET O
+STD PROPN B-AC
+induces VERB O
+stimulus NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+adaptation NOUN I-LF
+( PUNCT O
+SSA PROPN B-AC
+) PUNCT O
+on ADP O
+AC PROPN B-AC
+neurons NOUN O
+[ X O
+15,16 NUM O
+] PUNCT O
+, PUNCT O
+whose DET O
+frequency NOUN O
+channels NOUN O
+simply ADV O
+remain VERB O
+fresh ADJ O
+to ADP O
+keep VERB O
+responding VERB O
+to ADP O
+the DET O
+DEV PROPN B-AC
+[ X O
+17,18 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+North PROPN B-LF
+American PROPN I-LF
+Consortium PROPN I-LF
+for ADP I-LF
+the DET I-LF
+Study PROPN I-LF
+of ADP I-LF
+End PROPN I-LF
+- PUNCT I-LF
+stage NOUN I-LF
+Liver PROPN I-LF
+Disease PROPN I-LF
+- PUNCT I-LF
+Acute PROPN I-LF
+on ADP I-LF
+Chronic PROPN I-LF
+Liver PROPN I-LF
+Failure PROPN I-LF
+( PUNCT O
+NACSELD PROPN B-AC
+- PUNCT B-AC
+ACLF PROPN B-AC
+) PUNCT O
+definition NOUN O
+was AUX O
+used VERB O
+to PART O
+categorize VERB O
+patients NOUN O
+with ADP O
+acute ADJ O
+on ADP O
+chronic ADJ O
+liver NOUN O
+failure NOUN O
+on ADP O
+the DET O
+first ADJ O
+day NOUN O
+of ADP O
+hospitalization NOUN O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+conducted VERB O
+health NOUN O
+facility NOUN O
+assessments NOUN O
+between ADP O
+July PROPN O
+2015 NUM O
+- PUNCT O
+April PROPN O
+2016 NUM O
+, PUNCT O
+with ADP O
+retrospective ADJ O
+review NOUN O
+of ADP O
+admission NOUN O
+events NOUN O
+between ADP O
+1st NOUN O
+July PROPN O
+2014 NUM O
+and CCONJ O
+30th NOUN O
+June PROPN O
+2015 NUM O
+, PUNCT O
+and CCONJ O
+used VERB O
+estimates NOUN O
+of ADP O
+population NOUN O
+- PUNCT O
+based VERB O
+incidence NOUN O
+of ADP O
+neonatal ADJ O
+conditions NOUN O
+in ADP O
+Nairobi PROPN O
+to PART O
+explore VERB O
+access NOUN O
+and CCONJ O
+evaluate VERB O
+readiness NOUN O
+of ADP O
+public ADJ O
+, PUNCT O
+private ADJ B-LF
+not PART I-LF
+- PUNCT I-LF
+for ADP I-LF
+- PUNCT I-LF
+profit NOUN I-LF
+( PUNCT O
+mission NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+private ADJ B-LF
+- PUNCT I-LF
+for ADP I-LF
+- PUNCT I-LF
+profit NOUN I-LF
+( PUNCT O
+private ADJ B-AC
+) PUNCT O
+sector NOUN O
+facilities NOUN O
+providing VERB O
+24/7 NUM B-AC
+inpatient ADJ O
+neonatal ADJ O
+care NOUN O
+in ADP O
+Nairobi PROPN O
+City PROPN O
+County PROPN O
+. PUNCT O
+
+BIC PROPN B-AC
+, PUNCT O
+Bayesian PROPN B-LF
+Information PROPN I-LF
+Criterion PROPN I-LF
+, PUNCT O
+ME PROPN B-AC
+, PUNCT O
+master NOUN B-LF
+equation NOUN I-LF
+. PUNCT O
+
+DMSO PROPN O
+, PUNCT O
+dimethyl NOUN O
+sulfoxide NOUN O
+; PUNCT O
+NPM1 PROPN B-AC
+, PUNCT O
+Nucleophosmin NOUN B-LF
+1 NUM I-LF
+; PUNCT O
+p53 NOUN B-AC
+: PUNCT O
+protein NOUN B-LF
+53 NUM I-LF
+; PUNCT O
+siRNA NOUN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+; PUNCT O
+S34F PROPN B-AC
+, PUNCT O
+serine-34 NOUN B-LF
+to ADP I-LF
+phenylalanine NOUN I-LF
+substitution NOUN I-LF
+; PUNCT O
+WST-1 PROPN B-AC
+, PUNCT O
+water NOUN B-LF
+- PUNCT I-LF
+soluble ADJ I-LF
+tetrazolium-1 NOUN I-LF
+; PUNCT O
+wt NOUN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+X NOUN B-LF
+- PUNCT I-LF
+ray NOUN I-LF
+absorption NOUN I-LF
+spectroscopy NOUN I-LF
+( PUNCT O
+XAS NOUN B-AC
+) PUNCT O
+facilitates VERB O
+monitoring NOUN O
+of ADP O
+redox NOUN O
+and CCONJ O
+geometry NOUN O
+changes NOUN O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+determination NOUN O
+of ADP O
+precise ADJ O
+interatomic ADJ O
+distances NOUN O
+at ADP O
+protein NOUN O
+- PUNCT O
+bound VERB O
+metal NOUN O
+centers NOUN O
+[ PUNCT O
+27 NUM O
+, PUNCT O
+28 NUM O
+] PUNCT O
+. PUNCT O
+
+Bayley PROPN B-AC
+- PUNCT B-AC
+III PROPN B-AC
+, PUNCT O
+Bayley PROPN B-LF
+Scales PROPN I-LF
+of ADP I-LF
+Infant PROPN I-LF
+and CCONJ I-LF
+Toddler PROPN I-LF
+Development PROPN I-LF
+– PUNCT I-LF
+Third PROPN I-LF
+Edition PROPN I-LF
+; PUNCT O
+CBQ PROPN B-AC
+, PUNCT O
+Children NOUN B-LF
+’s PART I-LF
+Behavior NOUN I-LF
+Questionnaire NOUN I-LF
+; PUNCT O
+SDQ PROPN B-AC
+, PUNCT O
+Strengths NOUN B-LF
+and CCONJ I-LF
+Difficulties PROPN I-LF
+Questionnaire NOUN I-LF
+. PUNCT O
+
+AC PROPN B-AC
+, PUNCT O
+auditory ADJ B-LF
+cortex NOUN I-LF
+; PUNCT O
+BF NOUN B-AC
+, PUNCT O
+best ADJ B-LF
+frequency NOUN I-LF
+; PUNCT O
+CF NOUN B-AC
+, PUNCT O
+characteristic ADJ B-LF
+frequency NOUN I-LF
+; PUNCT O
+PSTH NOUN B-AC
+, PUNCT O
+peri NOUN B-LF
+- PUNCT I-LF
+stimulus NOUN I-LF
+time NOUN I-LF
+histogram NOUN I-LF
+. PUNCT O
+
+AAV PROPN B-AC
+, PUNCT O
+adeno NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+virus NOUN I-LF
+; PUNCT O
+CNO PROPN B-AC
+, PUNCT O
+clozapine NOUN B-LF
+- PUNCT I-LF
+n CCONJ I-LF
+- PUNCT I-LF
+oxide NOUN I-LF
+; PUNCT O
+hSyn PROPN O
+, PUNCT O
+human ADJ O
+Synapsin-1 PROPN O
+; PUNCT O
+i.p NOUN B-AC
+. PUNCT O
+, PUNCT O
+intraperitoneal ADJ B-LF
+; PUNCT O
+L PROPN O
+- PUNCT O
+ITR PROPN O
+, PUNCT O
+left ADJ O
+inverted ADJ O
+terminal ADJ O
+repeat NOUN O
+; PUNCT O
+LH PROPN B-AC
+, PUNCT O
+lateral ADJ B-LF
+hypothalamic ADJ I-LF
+area NOUN I-LF
+; PUNCT O
+LMA PROPN B-AC
+, PUNCT O
+locomotor ADJ B-LF
+activity NOUN I-LF
+; PUNCT O
+NREM PROPN B-AC
+, PUNCT O
+non ADJ B-LF
+- PUNCT I-LF
+rapid ADJ I-LF
+eye NOUN I-LF
+movement NOUN I-LF
+; PUNCT O
+Nts PROPN B-AC
+, PUNCT O
+neurotensin NOUN B-LF
+; PUNCT O
+R PROPN O
+- PUNCT O
+ITR PROPN O
+, PUNCT O
+right ADJ O
+inverted ADJ O
+terminal ADJ O
+repeat NOUN O
+; PUNCT O
+REM PROPN B-AC
+, PUNCT O
+rapid ADJ B-LF
+eye NOUN I-LF
+movement NOUN I-LF
+; PUNCT O
+RM PROPN O
+, PUNCT O
+repeated VERB O
+measures NOUN O
+; PUNCT O
+SA PROPN O
+, PUNCT O
+saline NOUN O
+; PUNCT O
+Tb PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+temperature NOUN I-LF
+; PUNCT O
+WPRE PROPN B-AC
+, PUNCT O
+woodchuck NOUN B-LF
+hepatitis NOUN I-LF
+virus NOUN I-LF
+posttranscriptional ADJ I-LF
+control NOUN I-LF
+element NOUN I-LF
+. PUNCT O
+
+We PRON O
+examined VERB O
+GAPDH PROPN B-AC
+properties NOUN O
+in ADP O
+acute ADJ O
+mouse NOUN O
+liver NOUN O
+injury NOUN O
+due ADP O
+to ADP O
+ethanol NOUN O
+and/or CCONJ O
+acetaminophen NOUN B-LF
+( PUNCT O
+APAP PROPN B-AC
+) PUNCT O
+treatment NOUN O
+. PUNCT O
+
+This DET O
+property NOUN O
+allows VERB O
+MIS416 PROPN O
+to ADP O
+be AUX O
+exploited VERB O
+as ADP O
+a DET O
+vehicle NOUN O
+for ADP O
+the DET O
+delivery NOUN O
+of ADP O
+peptide NOUN O
+antigens NOUN O
+or CCONJ O
+other ADJ O
+molecules NOUN O
+( PUNCT O
+for ADP O
+example NOUN O
+, PUNCT O
+nucleic ADJ O
+acids NOUN O
+) PUNCT O
+to ADP O
+DCs PROPN B-AC
+. PUNCT O
+We PRON O
+previously ADV O
+showed VERB O
+that SCONJ O
+covalent ADJ O
+( PUNCT O
+non ADJ O
+- ADJ O
+cleavable ADJ O
+) PUNCT O
+conjugation NOUN O
+of ADP O
+OVA PROPN B-AC
+, PUNCT O
+a DET O
+model NOUN O
+antigen NOUN O
+derived VERB O
+from ADP O
+ovalbumin NOUN B-LF
+, PUNCT O
+to ADP O
+MIS416 PROPN O
+enhanced VERB O
+immune ADJ O
+responses NOUN O
+in ADP O
+DCs PROPN B-AC
+in ADP O
+vivo ADJ O
+, PUNCT O
+compared VERB O
+to ADP O
+unconjugated ADJ O
+MIS416 PROPN O
+and CCONJ O
+OVA PROPN B-AC
+. PUNCT O
+Intracellular ADJ O
+trafficking NOUN O
+promotes VERB O
+the DET O
+lysosomal ADJ O
+degradation NOUN O
+of ADP O
+MIS416 PROPN O
+, PUNCT O
+leading VERB O
+to ADP O
+the DET O
+destruction NOUN O
+of ADP O
+MIS416 PROPN O
+plus CCONJ O
+the DET O
+associated VERB O
+cargos NOUN O
+conjugated VERB O
+to ADP O
+MIS416 PROPN O
+. PUNCT O
+
+The DET O
+results NOUN O
+revealed VERB O
+that SCONJ O
+PFKP PROPN B-AC
+protein NOUN O
+levels NOUN O
+were AUX O
+positively ADV O
+related ADJ O
+to ADP O
+American PROPN B-LF
+Joint PROPN I-LF
+Committee PROPN I-LF
+on ADP I-LF
+Cancer PROPN I-LF
+( PUNCT O
+AJCC PROPN B-AC
+) PUNCT O
+stage NOUN O
+( PUNCT O
+P NOUN O
+= SYM O
+0.042 NUM O
+, PUNCT O
+Table NOUN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+To PART O
+determine VERB O
+the DET O
+thermal ADJ O
+stability NOUN O
+of ADP O
+M10.5 NUM O
+, PUNCT O
+we PRON O
+monitored VERB O
+heat NOUN O
+- PUNCT O
+induced VERB O
+unfolding NOUN O
+by ADP O
+recording VERB O
+the DET O
+circular ADJ B-LF
+dichroism NOUN I-LF
+( PUNCT O
+CD NOUN B-AC
+) PUNCT O
+signal NOUN O
+at ADP O
+223 NUM O
+nm NOUN O
+as ADP O
+a DET O
+function NOUN O
+of ADP O
+increasing VERB O
+temperature NOUN O
+. PUNCT O
+
+Mature ADJ O
+gametocytes NOUN O
+are AUX O
+sexually ADV O
+dimorphic ADJ O
+, PUNCT O
+forming VERB O
+microgametocytes NOUN O
+and CCONJ O
+macrogametocytes NOUN O
+that PRON O
+escape VERB O
+the DET O
+red ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+( PUNCT O
+RBC NOUN B-AC
+) PUNCT O
+and CCONJ O
+produce VERB O
+male ADJ O
+and CCONJ O
+female ADJ O
+gametes NOUN O
+in ADP O
+the DET O
+blood NOUN O
+meal NOUN O
+of ADP O
+the DET O
+mosquito NOUN O
+by ADP O
+processes NOUN O
+known VERB O
+as ADP O
+exflagellation NOUN O
+[ X O
+8 NUM O
+] X O
+and CCONJ O
+activation NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+we PRON O
+estimated VERB O
+the DET O
+likelihood NOUN B-LF
+to ADP I-LF
+be AUX I-LF
+helped VERB I-LF
+or CCONJ I-LF
+harmed VERB I-LF
+( PUNCT O
+LHH PROPN B-AC
+) PUNCT O
+, PUNCT O
+defined VERB O
+as ADP O
+the DET O
+ratio NOUN O
+of ADP O
+the DET O
+NNH NOUN B-AC
+to ADP O
+NNT NOUN B-AC
+; PUNCT O
+LLH PROPN O
+values NOUN O
+< ADP O
+1 NUM O
+indicated VERB O
+that SCONJ O
+the DET O
+number NOUN O
+of ADP O
+incident NOUN O
+cases NOUN O
+of ADP O
+T2D NOUN B-AC
+incurred VERB O
+exceeded VERB O
+the DET O
+number NOUN O
+of ADP O
+ASCVD PROPN B-AC
+events NOUN O
+prevented VERB O
+[ PUNCT O
+38 NUM O
+] PUNCT O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+HKDB PROPN B-AC
+, PUNCT O
+Hong PROPN B-LF
+Kong PROPN I-LF
+Diabetes PROPN I-LF
+Biobank PROPN I-LF
+; PUNCT O
+PRS PROPN B-AC
+, PUNCT O
+polygenic ADJ B-LF
+risk NOUN I-LF
+score NOUN I-LF
+. PUNCT O
+
+To ADP O
+date NOUN O
+, PUNCT O
+several ADJ O
+candidates NOUN O
+have AUX O
+been AUX O
+proposed VERB O
+to PART O
+act VERB O
+as ADP O
+self NOUN O
+- X O
+Ags NOUN B-AC
+for ADP O
+iNKT PROPN B-AC
+cells NOUN O
+, PUNCT O
+including VERB O
+β NOUN O
+- X O
+linked ADJ O
+glycosphingolipids NOUN B-LF
+( PUNCT O
+GSLs PROPN B-AC
+) PUNCT O
+( PUNCT O
+isoglobotrihexosylceramide NOUN B-LF
+[ PUNCT O
+iGb3 X B-AC
+] PUNCT O
+[ PUNCT O
+4,5 NUM O
+] PUNCT O
+, PUNCT O
+gangliosides NOUN O
+[ PUNCT O
+6,7 NUM O
+] PUNCT O
+and CCONJ O
+β NOUN B-LF
+- X I-LF
+glucosylceramide NOUN I-LF
+[ PUNCT O
+β NOUN B-AC
+- X B-AC
+GlcCer X B-AC
+] PUNCT O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+phospholipids NOUN O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+
+Additionally ADV O
+, PUNCT O
+dried VERB B-LF
+blood NOUN I-LF
+spots NOUN I-LF
+( PUNCT O
+DBS NOUN B-AC
+) PUNCT O
+were AUX O
+collected VERB O
+and CCONJ O
+stored VERB O
+for ADP O
+molecular ADJ O
+testing NOUN O
+of ADP O
+parasites NOUN O
+. PUNCT O
+
+Volunteers NOUN O
+transcribe VERB O
+patient NOUN O
+demographic ADJ O
+, PUNCT O
+diagnostic ADJ O
+, PUNCT O
+and CCONJ O
+treatment NOUN O
+data NOUN O
+into ADP O
+the DET O
+patient NOUN B-LF
+information NOUN I-LF
+system NOUN I-LF
+( PUNCT O
+PIS PROPN B-AC
+) PUNCT O
+software NOUN O
+( PUNCT O
+custom ADV O
+- PUNCT O
+built VERB O
+by ADP O
+Orbis PROPN O
+Bangladesh PROPN O
+, PUNCT O
+Dhaka PROPN O
+, PUNCT O
+Bangladesh PROPN O
+) PUNCT O
+. PUNCT O
+
+DR NOUN B-AC
+- PUNCT B-AC
+TB NOUN B-AC
+, PUNCT O
+drug NOUN B-LF
+- PUNCT I-LF
+resistant ADJ I-LF
+tuberculosis NOUN I-LF
+; PUNCT O
+TB NOUN B-AC
+, PUNCT O
+tuberculosis NOUN B-LF
+. PUNCT O
+
+Please INTJ O
+add VERB O
+the DET O
+following ADJ O
+statement NOUN O
+, PUNCT O
+or CCONJ O
+similar ADJ O
+, PUNCT O
+to ADP O
+the DET O
+Methods NOUN O
+: PUNCT O
+" PUNCT O
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+as ADP O
+per ADP O
+the DET O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+guideline NOUN O
+( PUNCT O
+S1 PROPN O
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+" PUNCT O
+
+Accordingly ADV O
+, PUNCT O
+this DET O
+research NOUN O
+proposes VERB O
+a DET O
+Memetic PROPN O
+Differential PROPN B-LF
+Evolution PROPN I-LF
+algorithm NOUN I-LF
+( PUNCT O
+MDETC PROPN B-AC
+) PUNCT O
+to PART O
+solve VERB O
+the DET O
+text NOUN O
+clustering NOUN O
+problem NOUN O
+, PUNCT O
+which PRON O
+aims VERB O
+to PART O
+address VERB O
+the DET O
+effect NOUN O
+of ADP O
+the DET O
+hybridization NOUN O
+between ADP O
+the DET O
+differential ADJ O
+evolution NOUN O
+( PUNCT O
+DE PROPN B-AC
+) PUNCT O
+mutation NOUN O
+strategy NOUN O
+with ADP O
+the DET O
+memetic ADJ B-LF
+algorithm NOUN I-LF
+( PUNCT O
+MA NOUN B-AC
+) PUNCT O
+. PUNCT O
+This DET O
+hybridization NOUN O
+intends VERB O
+to PART O
+enhance VERB O
+the DET O
+quality NOUN O
+of ADP O
+text NOUN O
+clustering NOUN O
+and CCONJ O
+improve VERB O
+the DET O
+exploitation NOUN O
+and CCONJ O
+exploration NOUN O
+capabilities NOUN O
+of ADP O
+the DET O
+algorithm NOUN O
+. PUNCT O
+
+AUC PROPN B-AC
+is AUX O
+the DET O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+receiver NOUN I-LF
+operating NOUN I-LF
+characteristic NOUN I-LF
+curve NOUN I-LF
+, PUNCT O
+COR PROPN O
+is AUX O
+point NOUN O
+biserial ADJ O
+correlation NOUN O
+coefficient NOUN O
+, PUNCT O
+AIC PROPN O
+is AUX O
+the DET O
+Akaike PROPN O
+information NOUN O
+criterion NOUN O
+, PUNCT O
+and CCONJ O
+BIC PROPN O
+is AUX O
+the DET O
+Bayesian ADJ O
+information NOUN O
+criterion NOUN O
+. PUNCT O
+
+Minimal ADJ B-LF
+medium NOUN I-LF
+( PUNCT O
+MM NOUN B-AC
+) PUNCT O
+was AUX O
+formulated VERB O
+as SCONJ O
+previously ADV O
+described VERB O
+[ X O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+AL PROPN O
+, PUNCT O
+artemether NOUN O
+– SYM O
+lumefantrine NOUN O
+fixed ADJ O
+- PUNCT O
+dose NOUN O
+combination NOUN O
+; PUNCT O
+AQ PROPN O
++ SYM O
+AS PROPN O
+, PUNCT O
+artesunate NOUN O
++ SYM O
+amodiaquine NOUN O
+non ADJ O
+- PUNCT O
+fixed ADJ O
+dose NOUN O
+combination NOUN O
+; PUNCT O
+ASAQ PROPN B-AC
+, PUNCT O
+artesunate NOUN B-LF
+– SYM I-LF
+amodiaquine NOUN I-LF
+fixed ADJ O
+- PUNCT O
+dose NOUN O
+combination NOUN O
+; PUNCT O
+CQ PROPN O
+, PUNCT O
+chloroquine NOUN O
+; PUNCT O
+DP PROPN O
+, PUNCT O
+dihydroartemisinin NOUN O
+– SYM O
+piperaquine NOUN O
+fixed ADJ O
+- PUNCT O
+dose NOUN O
+combination NOUN O
+; PUNCT O
+ECG PROPN O
+, PUNCT O
+electrocardiogram NOUN O
+; PUNCT O
+PA PROPN O
+, PUNCT O
+pyronaridine NOUN O
+– SYM O
+artesunate NOUN O
+fixed ADJ O
+- PUNCT O
+dose NOUN O
+combination NOUN O
+; PUNCT O
+PK PROPN O
+, PUNCT O
+pharmacokinetic ADJ O
+; PUNCT O
+TdP PROPN B-AC
+, PUNCT O
+torsades X B-LF
+de X I-LF
+pointes X I-LF
+; PUNCT O
+WANECAM PROPN B-AC
+, PUNCT O
+West PROPN B-LF
+African PROPN I-LF
+Network PROPN I-LF
+for ADP I-LF
+Clinical PROPN I-LF
+Trials PROPN I-LF
+of ADP I-LF
+Antimalarial PROPN I-LF
+Drugs PROPN I-LF
+. PUNCT O
+
+Diamond NOUN O
+denotes VERB O
+the DET O
+pooled VERB O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+) PUNCT O
+indicating VERB O
+reduced VERB O
+risk NOUN O
+( PUNCT O
+OR NOUN B-AC
+0.37 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+conducted VERB O
+a DET O
+prospective ADJ O
+, PUNCT O
+single ADJ O
+- PUNCT O
+center NOUN O
+, PUNCT O
+cohort NOUN O
+study NOUN O
+in ADP O
+the DET O
+Liver PROPN O
+Transplant PROPN O
+Unit PROPN O
+at ADP O
+King PROPN B-LF
+Faisal PROPN I-LF
+Specialist PROPN I-LF
+Hospital PROPN I-LF
+and CCONJ I-LF
+Research PROPN I-LF
+Centre PROPN I-LF
+( PUNCT O
+KFSH&RC PROPN B-AC
+) PUNCT O
+from ADP O
+April PROPN O
+2016 NUM O
+to ADP O
+February PROPN O
+2020 NUM O
+. PUNCT O
+
+Body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+was AUX O
+calculated VERB O
+as ADP O
+weight NOUN O
+( PUNCT O
+kg)/height NOUN O
+( PUNCT O
+m NOUN O
+) PUNCT O
+squared VERB O
+. PUNCT O
+
+ANC PROPN B-AC
+: PUNCT O
+Antenatal ADJ B-LF
+care NOUN I-LF
+. PUNCT O
+
+Serum ADJ B-LF
+amyloid NOUN I-LF
+A PROPN I-LF
+( PUNCT O
+SAA PROPN B-AC
+) PUNCT O
+phosphorylated VERB O
+at ADP O
+serine NOUN O
+166 NUM O
+( PUNCT O
+pS166 NOUN O
+) PUNCT O
+, PUNCT O
+kininogen NOUN O
+1 NUM O
+phosphorylated VERB O
+at ADP O
+threonine NOUN O
+326 NUM O
+( PUNCT O
+pT326 NOUN O
+) PUNCT O
+, PUNCT O
+Fibrinogen NOUN O
+α NOUN O
+phosphorylated VERB O
+at ADP O
+threonine NOUN O
+20 NUM O
+( PUNCT O
+pT20 NOUN O
+) PUNCT O
+and CCONJ O
+at ADP O
+serine NOUN O
+22 NUM O
+( PUNCT O
+pS22 NOUN O
+) PUNCT O
+are AUX O
+shown VERB O
+for ADP O
+samples NOUN O
+from ADP O
+controls NOUN O
+( PUNCT O
+C NOUN O
+) PUNCT O
+and CCONJ O
+samples NOUN O
+from ADP O
+dogs NOUN O
+suffering VERB O
+from ADP O
+babesiosis NOUN O
+( PUNCT O
+B NOUN O
+) PUNCT O
+. PUNCT O
+p NOUN O
+- PUNCT O
+value NOUN O
+for ADP O
+the DET O
+comparison NOUN O
+C NOUN O
+vs. ADP O
+
+Previously ADV O
+, PUNCT O
+it PRON O
+was AUX O
+shown VERB O
+that SCONJ O
+endothelial ADJ B-LF
+progenitor NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+EPCs NOUN B-AC
+) PUNCT O
+are AUX O
+increased VERB O
+during ADP O
+human ADJ O
+pregnancy NOUN O
+[ X O
+72 NUM O
+] PUNCT O
+and CCONJ O
+that SCONJ O
+EPCs NOUN B-AC
+directly ADV O
+contribute VERB O
+to ADP O
+ECs NOUN B-AC
+within ADP O
+decidual ADJ O
+vasculature NOUN O
+by ADP O
+vasculogenesis NOUN O
+in ADP O
+mouse NOUN O
+pregnancy NOUN O
+[ X O
+73 NUM O
+] PUNCT O
+. PUNCT O
+
+Our PRON O
+group NOUN O
+has AUX O
+therefore ADV O
+utilized VERB O
+a DET O
+glycosylation NOUN B-LF
+independent ADJ I-LF
+lysosomal NOUN I-LF
+targeting NOUN I-LF
+( PUNCT O
+GILT PROPN B-AC
+) PUNCT O
+system NOUN O
+, PUNCT O
+whereby SCONJ O
+IGF2 PROPN B-AC
+has AUX O
+been AUX O
+fused VERB O
+to ADP O
+rhNAGLU NOUN B-AC
+( PUNCT O
+rhNAGLU NOUN B-AC
+- PUNCT O
+IGF2 PROPN B-AC
+; PUNCT O
+BMN PROPN O
+250 NUM O
+) PUNCT O
+to ADP O
+mediate VERB O
+CI NOUN B-AC
+- PUNCT B-AC
+MPR NOUN B-AC
+- PUNCT O
+mediated VERB O
+cellular ADJ O
+uptake NOUN O
+and CCONJ O
+delivery NOUN O
+to ADP O
+lysosomes NOUN O
+[ X O
+18–20 NUM O
+] PUNCT O
+. PUNCT O
+
+Logistic ADJ O
+regression NOUN O
+analyses NOUN O
+were AUX O
+used VERB O
+to PART O
+determine VERB O
+whether SCONJ O
+MS PROPN B-AC
+and/or CCONJ O
+its PRON O
+various ADJ O
+components NOUN O
+were AUX O
+significant ADJ O
+factors NOUN O
+associated VERB O
+with ADP O
+the DET O
+presence NOUN O
+of ADP O
+SDB PROPN B-AC
+. PUNCT O
+Continuous ADJ O
+data NOUN O
+were AUX O
+expressed VERB O
+as ADP O
+the DET O
+mean NOUN O
+± SYM O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT O
+SD NOUN B-AC
+) PUNCT O
+and CCONJ O
+compared VERB O
+by ADP O
+Student PROPN O
+t NOUN O
+test NOUN O
+or CCONJ O
+non ADJ O
+- ADJ O
+parametric ADJ O
+test NOUN O
+, PUNCT O
+when SCONJ O
+appropriate ADJ O
+. PUNCT O
+
+The DET O
+sporozoites NOUN O
+travel VERB O
+to ADP O
+the DET O
+liver NOUN O
+and CCONJ O
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+in ADP O
+hepatocytes NOUN O
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+exoerythrocytic ADJ B-LF
+forms NOUN I-LF
+( PUNCT O
+EEFs NOUN B-AC
+) PUNCT O
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+5,6 NUM O
+] PUNCT O
+. PUNCT O
+
+Objective NOUN O
+of ADP O
+this DET O
+study NOUN O
+was AUX O
+to PART O
+evaluate VERB O
+the DET O
+effectiveness NOUN O
+of ADP O
+the DET O
+iterative ADJ B-LF
+reconstruction NOUN I-LF
+of ADP I-LF
+high ADJ I-LF
+- PUNCT I-LF
+pitch NOUN I-LF
+dual ADJ I-LF
+- PUNCT I-LF
+source NOUN I-LF
+chest NOUN I-LF
+CT NOUN I-LF
+( PUNCT O
+IR NOUN B-AC
+- PUNCT B-AC
+HP NOUN B-AC
+- PUNCT B-AC
+CT NOUN B-AC
+) PUNCT O
+scanned VERB O
+with ADP O
+low ADJ O
+radiation NOUN O
+exposure NOUN O
+compared VERB O
+with ADP O
+low ADJ O
+dose NOUN O
+chest NOUN O
+CT NOUN O
+( PUNCT O
+LDCT PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+The DET O
+differentially ADV B-LF
+methylated VERB I-LF
+regions NOUN I-LF
+( PUNCT O
+DMRs NOUN B-AC
+) PUNCT O
+that PRON O
+were AUX O
+located VERB O
+in ADP O
+promoter NOUN O
+regions NOUN O
+and CCONJ O
+completely ADV O
+overlapped VERB O
+with ADP O
+CpG NOUN B-LF
+islands NOUN I-LF
+( PUNCT O
+CGI PROPN B-AC
+) PUNCT O
+were AUX O
+identified VERB O
+as ADP O
+candidate NOUN O
+DMRs NOUN B-AC
+. PUNCT O
+Gene NOUN B-LF
+ontology NOUN I-LF
+( PUNCT O
+GO PROPN B-AC
+) PUNCT O
+analysis NOUN O
+and CCONJ O
+Pathway PROPN O
+analysis NOUN O
+were AUX O
+performed VERB O
+to PART O
+determine VERB O
+the DET O
+roles NOUN O
+of ADP O
+the DET O
+candidate NOUN O
+DMRs NOUN B-AC
+’ PART O
+corresponding VERB O
+genes NOUN O
+in ADP O
+biological ADJ O
+pathways NOUN O
+or CCONJ O
+identify VERB O
+GO PROPN B-AC
+terms NOUN O
+using VERB O
+MAS PROPN O
+3.0 NUM O
+( PUNCT O
+http://bioinfo.capitalbio.com/mas3/ X O
+) PUNCT O
+. PUNCT O
+
+LN PROPN B-AC
+, PUNCT O
+linear ADJ B-LF
+– PUNCT I-LF
+nonlinear ADJ I-LF
+; PUNCT O
+STRF PROPN B-AC
+, PUNCT O
+spectrotemporal ADJ B-LF
+receptive ADJ I-LF
+field NOUN I-LF
+. PUNCT O
+
+MDA PROPN B-AC
+is AUX O
+unstable ADJ O
+and CCONJ O
+can AUX O
+further ADV O
+react VERB O
+with ADP O
+acetaldehyde NOUN O
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+form VERB O
+malondialdehyde NOUN B-LF
+acetaldehyde NOUN I-LF
+- PUNCT O
+modified VERB O
+LDL PROPN B-AC
+( PUNCT O
+MAA PROPN B-AC
+- PUNCT O
+LDL PROPN B-AC
+) PUNCT O
+[ PUNCT O
+4–6 NUM O
+] PUNCT O
+. PUNCT O
+
+At ADP O
+12 NUM O
+weeks NOUN O
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+infant NOUN O
+age NOUN O
+, PUNCT O
+mean ADJ O
+anti ADJ O
+- ADJ O
+diphtheria ADJ O
+titres NOUN O
+were AUX O
+significantly ADV O
+higher ADJ O
+in ADP O
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+born VERB O
+to ADP O
+mothers NOUN O
+who PRON O
+received VERB O
+MMN PROPN B-AC
+( PUNCT O
+0.16 NUM O
+IU NOUN O
+/ SYM O
+mL NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X O
+CI NOUN B-AC
+] X O
+0.14–0.19 NUM O
+) PUNCT O
+or CCONJ O
+PE PROPN B-AC
++ SYM O
+MMN PROPN B-AC
+( PUNCT O
+0.14 NUM O
+IU NOUN O
+/ SYM O
+mL NOUN O
+, PUNCT O
+0.12–0.16 NUM O
+) PUNCT O
+during ADP O
+pregnancy NOUN O
+compared VERB O
+with ADP O
+FeFol PROPN B-AC
+( PUNCT O
+0.10 NUM O
+IU NOUN O
+/ SYM O
+mL NOUN O
+, PUNCT O
+0.09–0.12 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+most ADV O
+common ADJ O
+diagnoses NOUN O
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+tract NOUN O
+infection NOUN O
+caused VERB O
+by ADP O
+RSV PROPN O
+, PUNCT O
+influenza NOUN O
+B PROPN O
+, PUNCT O
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+, PUNCT O
+enterovirus NOUN O
+and CCONJ O
+influenza NOUN O
+A PROPN O
+, PUNCT O
+whereas SCONJ O
+the DET O
+most ADV O
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+bacterial ADJ O
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+Group PROPN B-LF
+A PROPN I-LF
+streptococci NOUN I-LF
+( PUNCT O
+GAS PROPN B-AC
+) PUNCT O
+, PUNCT O
+CXR PROPN B-AC
+- PUNCT O
+confirmed VERB O
+pneumonia NOUN O
+and CCONJ O
+Shigella PROPN O
+gastroenteritis NOUN O
+( PUNCT O
+Fig NOUN O
+6 NUM O
+, PUNCT O
+Fig NOUN O
+7B NUM O
+and CCONJ O
+7C NUM O
+) PUNCT O
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+Lopez PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+reported VERB O
+that SCONJ O
+GE PROPN O
+deteriorates VERB O
+as SCONJ O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+increases VERB O
+in ADP O
+nondiabetic ADJ O
+individuals NOUN O
+, PUNCT O
+whereas SCONJ O
+Healy PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+reported VERB O
+contrasting VERB O
+findings NOUN O
+[ PUNCT O
+13 NUM O
+, PUNCT O
+14 NUM O
+] PUNCT O
+. PUNCT O
+
+TY PROPN B-AC
+, PUNCT O
+time NOUN O
+yield NOUN O
+; PUNCT O
+STY PROPN B-AC
+, PUNCT O
+space NOUN O
+- PUNCT O
+time NOUN O
+yield NOUN O
+; PUNCT O
+VB PROPN B-AC
+, PUNCT O
+virus NOUN B-LF
+bioreactor NOUN I-LF
+. PUNCT O
+
+The DET O
+study NOUN O
+was AUX O
+approved VERB O
+by ADP O
+the DET O
+scientific ADJ O
+committee NOUN O
+of ADP O
+the DET O
+Dutch ADJ B-LF
+pathology NOUN I-LF
+registry NOUN I-LF
+( PUNCT O
+PALGA PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+Dutch ADJ O
+perinatal ADJ O
+registry NOUN O
+( PUNCT O
+Perined PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+ER NOUN B-AC
+, PUNCT O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+. PUNCT O
+
+Mohammadi PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+[ X O
+68 NUM O
+] X O
+investigated VERB O
+antibacterial ADJ O
+efficacy NOUN O
+on ADP O
+Streptococcus PROPN B-LF
+mutans NOUN I-LF
+( PUNCT O
+S. PROPN B-AC
+mutans NOUN B-AC
+) PUNCT O
+and CCONJ O
+S. PROPN B-AC
+aureus NOUN B-AC
+, PUNCT O
+while SCONJ O
+Morgental PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+[ X O
+16 NUM O
+] X O
+used VERB O
+E. NOUN B-AC
+faecalis NOUN B-AC
+. PUNCT O
+
+Beside ADP O
+being AUX O
+a DET O
+risk NOUN O
+factor NOUN O
+for ADP O
+end ADJ B-LF
+- ADJ I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD PROPN B-AC
+) PUNCT O
+, PUNCT O
+CKD PROPN B-AC
+is AUX O
+an DET O
+important ADJ O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+( PUNCT O
+CVD NOUN B-AC
+) PUNCT O
+risk NOUN O
+factor NOUN O
+, PUNCT O
+and CCONJ O
+most ADJ O
+patients NOUN O
+with ADP O
+CKD PROPN B-AC
+die VERB O
+from ADP O
+CVD NOUN B-AC
+before SCONJ O
+any DET O
+renal ADJ O
+replacement NOUN O
+therapy NOUN O
+is AUX O
+initiated VERB O
+[ X O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Measurements NOUN O
+were AUX O
+conducted VERB O
+at ADP O
+12 NUM O
+and CCONJ O
+24 NUM O
+days NOUN B-LF
+after ADP I-LF
+planting NOUN I-LF
+( PUNCT O
+DAP PROPN B-AC
+) PUNCT O
+. PUNCT O
+Data NOUN O
+presented VERB O
+are AUX O
+means NOUN O
+± ADP O
+standard ADJ O
+error NOUN O
+. PUNCT O
+
+Screening NOUN O
+mammograms NOUN O
+are AUX O
+interpreted VERB O
+according VERB O
+to ADP O
+the DET O
+Breast PROPN B-LF
+Imaging PROPN I-LF
+Reporting PROPN I-LF
+and CCONJ I-LF
+Data PROPN I-LF
+System PROPN I-LF
+( PUNCT O
+BI PROPN B-AC
+- PUNCT B-AC
+RADS PROPN B-AC
+) PUNCT O
+scale NOUN O
+by ADP O
+trained VERB O
+breast NOUN O
+radiologists NOUN O
+[ PUNCT O
+19 NUM O
+] PUNCT O
+. PUNCT O
+
+Data NOUN O
+were AUX O
+collected VERB O
+from ADP O
+GeneXpert PROPN O
+software NOUN O
+and CCONJ O
+Laboratory PROPN B-LF
+Information PROPN I-LF
+System PROPN I-LF
+( PUNCT O
+LIS PROPN B-AC
+) PUNCT O
+databases NOUN O
+. PUNCT O
+
+The DET O
+Danish PROPN B-LF
+National PROPN I-LF
+Birth PROPN I-LF
+Cohort PROPN I-LF
+( PUNCT O
+DNBC PROPN B-AC
+) PUNCT O
+is AUX O
+, PUNCT O
+to PART O
+our PRON O
+knowledge NOUN O
+, PUNCT O
+one NUM O
+of ADP O
+the DET O
+first ADJ O
+large ADJ O
+prospective ADJ O
+studies NOUN O
+to PART O
+comprehensively ADV O
+assess VERB O
+dietary ADJ O
+intake NOUN O
+in ADP O
+pregnancy NOUN O
+and CCONJ O
+again ADV O
+during ADP O
+the DET O
+adolescent ADJ O
+years NOUN O
+. PUNCT O
+
+Such ADJ O
+resistance NOUN O
+can AUX O
+be AUX O
+explained VERB O
+by ADP O
+the DET O
+presence NOUN O
+, PUNCT O
+inside ADP O
+the DET O
+core NOUN O
+, PUNCT O
+of ADP O
+α NOUN O
+/ SYM O
+β NOUN O
+- PUNCT O
+type NOUN O
+small ADJ B-LF
+, PUNCT I-LF
+acid NOUN I-LF
+- PUNCT I-LF
+soluble ADJ I-LF
+spore NOUN I-LF
+proteins NOUN I-LF
+( PUNCT O
+SASPs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Confusion NOUN O
+matrices NOUN O
+of ADP O
+deep ADJ O
+transfer NOUN O
+learning NOUN O
+models NOUN O
+and CCONJ O
+ophthalmologists NOUN O
+in ADP O
+detecting VERB O
+activated VERB O
+dendritic ADJ B-LF
+cells NOUN I-LF
+( PUNCT O
+DCs NOUN B-AC
+) PUNCT O
+and CCONJ O
+inflammatory ADJ O
+cells NOUN O
+are AUX O
+shown VERB O
+. PUNCT O
+
+In ADP O
+order NOUN O
+to ADP O
+demonstrate VERB O
+the DET O
+involvement NOUN O
+of ADP O
+Nrf2 NOUN B-AC
+in ADP O
+the DET O
+activation NOUN O
+of ADP O
+HO-1 NOUN B-AC
+, PUNCT O
+GCLM PROPN B-AC
+and CCONJ O
+x NOUN B-AC
+- ADJ B-AC
+CT NOUN B-AC
+, PUNCT O
+Nrf2 NOUN B-AC
+activity NOUN O
+in ADP O
+BTZ PROPN B-AC
+- ADJ O
+treated VERB O
+cells NOUN O
+has AUX O
+been AUX O
+inhibited VERB O
+by ADP O
+all DET B-LF
+- ADJ I-LF
+trans ADJ I-LF
+- ADJ I-LF
+Retinoic ADJ I-LF
+acid NOUN I-LF
+( PUNCT O
+ATRA PROPN B-AC
+) PUNCT O
+. PUNCT O
+Indeed ADV O
+, PUNCT O
+retinoic ADJ O
+acid NOUN O
+receptors NOUN O
+RARalpha PROPN O
+and CCONJ O
+RXR PROPN O
+have AUX O
+been AUX O
+demonstrated VERB O
+to ADP O
+interfere VERB O
+with ADP O
+the DET O
+binding NOUN O
+of ADP O
+Nrf2 NOUN B-AC
+to ADP O
+ARE NOUN B-AC
+sequences NOUN O
+, PUNCT O
+decreasing VERB O
+the DET O
+transcription NOUN O
+of ADP O
+its PRON O
+target NOUN O
+genes NOUN O
+[ PUNCT O
+49 NUM O
+, PUNCT O
+67 NUM O
+] PUNCT O
+. PUNCT O
+
+Tuberculosis NOUN B-LF
+minisite NOUN O
+from ADP O
+the DET O
+World PROPN O
+Health PROPN O
+Organization PROPN O
+, PUNCT O
+providing VERB O
+data NOUN O
+on ADP O
+tuberculosis NOUN B-LF
+worldwide ADV O
+, PUNCT O
+details NOUN O
+of ADP O
+the DET O
+Stop VERB O
+TB PROPN B-AC
+strategy NOUN O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+fact NOUN O
+sheets NOUN O
+and CCONJ O
+current ADJ O
+guidelines NOUN O
+
+Previous ADJ O
+investigations NOUN O
+have AUX O
+determined VERB O
+the DET O
+role NOUN O
+of ADP O
+several ADJ O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT O
+SNPs NOUN B-AC
+) PUNCT O
+to PART O
+explain VERB O
+inter ADJ O
+- ADJ O
+individual ADJ O
+variability NOUN O
+of ADP O
+serum ADJ O
+creatine NOUN B-LF
+kinase NOUN I-LF
+( PUNCT O
+CK PROPN B-AC
+) PUNCT O
+concentrations NOUN O
+after ADP O
+exertional ADJ O
+muscle NOUN O
+damage NOUN O
+. PUNCT O
+
+All DET O
+predicted VERB O
+gene NOUN O
+- PUNCT O
+order NOUN O
+disruptions NOUN O
+identified VERB O
+using VERB O
+this DET O
+gene NOUN O
+- PUNCT O
+based VERB O
+BLAST NOUN O
+approach NOUN O
+are AUX O
+also ADV O
+identified VERB O
+as ADP O
+termini NOUN O
+of ADP O
+whole ADJ O
+- PUNCT O
+genome NOUN O
+global ADJ O
+alignments NOUN O
+at ADP O
+the DET B-LF
+University PROPN I-LF
+of ADP I-LF
+California PROPN I-LF
+, PUNCT I-LF
+Santa PROPN I-LF
+Cruz PROPN I-LF
+( PUNCT O
+UCSC PROPN B-AC
+) PUNCT O
+[ PUNCT O
+65 NUM O
+] PUNCT O
+. PUNCT O
+
+Cul4b PROPN B-AC
+, PUNCT O
+Cullin-4b NOUN B-LF
+; PUNCT O
+TCR PROPN B-AC
+, PUNCT O
+T PROPN B-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+We PRON O
+compared VERB O
+F75 PROPN B-AC
+to ADP O
+the DET O
+modified VERB B-LF
+F75 PROPN I-LF
+( PUNCT O
+mF75 NOUN B-AC
+) PUNCT O
+formulation NOUN O
+( PUNCT O
+Table PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+“ PUNCT O
+Negative ADJ B-LF
+Histopathology NOUN O
+” PUNCT O
+( PUNCT O
+NEG)–absence NOUN B-AC
+of ADP O
+granulomatous ADJ O
+changes NOUN O
+resembling VERB O
+OJD PROPN B-AC
+and CCONJ O
+no DET O
+AFOs NOUN B-AC
+detected VERB O
+. PUNCT O
+
+For ADP O
+the DET O
+underlying VERB O
+data NOUN O
+, PUNCT O
+see VERB O
+https://osf.io/VSZCB/. X O
+EEG NOUN B-AC
+, PUNCT O
+electroencephalography NOUN B-LF
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+highly ADV B-LF
+reducing VERB I-LF
+; PUNCT O
+NR PROPN B-AC
+, PUNCT O
+nonreducing VERB B-LF
+; PUNCT O
+NRPS PROPN B-AC
+, PUNCT O
+nonribosomal ADJ B-LF
+peptide NOUN I-LF
+synthase NOUN I-LF
+; PUNCT O
+PKS PROPN B-AC
+, PUNCT O
+polyketide NOUN B-LF
+synthase NOUN I-LF
+; PUNCT O
+SM PROPN B-AC
+, PUNCT O
+secondary ADJ B-LF
+metabolite NOUN I-LF
+. PUNCT O
+
+The DET O
+pulmonary ADJ O
+collectins NOUN O
+, PUNCT O
+surfactant NOUN B-LF
+proteins NOUN I-LF
+A PROPN O
+and CCONJ O
+D PROPN O
+( PUNCT O
+SP PROPN B-AC
+- PUNCT O
+A PROPN O
+and CCONJ O
+SP PROPN B-AC
+- PUNCT O
+D PROPN O
+) PUNCT O
+have AUX O
+been AUX O
+implicated VERB O
+in ADP O
+the DET O
+regulation NOUN O
+of ADP O
+the DET O
+innate ADJ O
+immune ADJ O
+system NOUN O
+within ADP O
+the DET O
+lung NOUN O
+. PUNCT O
+
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+RR PROPN B-AC
+, PUNCT O
+risk NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+Cytosolic ADJ O
+β NOUN O
+- PUNCT O
+catenin NOUN O
+protein NOUN O
+becomes VERB O
+stabilized ADJ O
+and CCONJ O
+newly ADV O
+synthesized VERB O
+β NOUN O
+- PUNCT O
+catenin NOUN O
+is AUX O
+able ADJ O
+to ADP O
+accumulate VERB O
+and CCONJ O
+then ADV O
+translocate VERB O
+to ADP O
+the DET O
+nucleus NOUN O
+where SCONJ O
+binding VERB O
+to ADP O
+T NOUN B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+factor NOUN I-LF
+( PUNCT O
+TCF)/lymphoid NOUN B-LF
+enhancer NOUN I-LF
+factor NOUN I-LF
+( PUNCT O
+LEF PROPN B-AC
+) PUNCT O
+transcription NOUN O
+factors NOUN O
+leads VERB O
+to ADP O
+the DET O
+activation NOUN O
+of ADP O
+target NOUN O
+gene NOUN O
+expression NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+IPA PROPN B-AC
+, PUNCT O
+Ingenuity PROPN B-LF
+Pathway PROPN I-LF
+Analysis NOUN I-LF
+. PUNCT O
+
+Moreover ADV O
+, PUNCT O
+the DET O
+release NOUN O
+of ADP O
+exosomes NOUN O
+from ADP O
+cells NOUN O
+was AUX O
+also ADV O
+observed VERB O
+following VERB O
+ionomycin NOUN O
+addition NOUN O
+but CCONJ O
+not PART O
+with ADP O
+granulocyte NOUN B-LF
+macrophage NOUN I-LF
+– PUNCT I-LF
+colony NOUN I-LF
+- PUNCT I-LF
+stimulating VERB I-LF
+factor NOUN I-LF
+( PUNCT O
+GM PROPN B-AC
+– PUNCT B-AC
+CSF PROPN B-AC
+) PUNCT O
+treatment NOUN O
+( PUNCT O
+S2C PROPN O
+and CCONJ O
+S2D PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+PPV PROPN B-AC
+) PUNCT O
+represents VERB O
+the DET O
+proportion NOUN O
+of ADP O
+test ADJ O
+- PUNCT O
+positive ADJ O
+specimens NOUN O
+that PRON O
+truly ADV O
+present VERB O
+the DET O
+target NOUN O
+disorder NOUN O
+, PUNCT O
+while SCONJ O
+the DET O
+negative ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+NPV PROPN B-AC
+) PUNCT O
+represents VERB O
+the DET O
+proportion NOUN O
+of ADP O
+test ADJ O
+- PUNCT O
+negative ADJ O
+specimens NOUN O
+that PRON O
+truly ADV O
+do AUX O
+not PART O
+present VERB O
+the DET O
+target NOUN O
+disorder NOUN O
+: PUNCT O
+and CCONJ O
+
+Underlying VERB O
+data NOUN O
+for ADP O
+Fig NOUN O
+8 NUM O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+br PROPN B-AC
+, PUNCT O
+broad ADJ B-LF
+; PUNCT O
+d NOUN O
+, PUNCT O
+day NOUN O
+; PUNCT O
+Dcp-1 PROPN B-AC
+, PUNCT O
+Death PROPN B-LF
+Caspase-1 PROPN I-LF
+; PUNCT O
+Dilp8 PROPN B-AC
+, PUNCT O
+Drosophila PROPN B-LF
+Insulin PROPN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+peptide NOUN I-LF
+8 NUM I-LF
+; PUNCT O
+EcRDN PROPN B-AC
+, PUNCT O
+dominant ADJ B-LF
+negative ADJ I-LF
+form NOUN I-LF
+of ADP I-LF
+ecdysone NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+egr NOUN B-AC
+, PUNCT O
+eiger NOUN B-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+L3 PROPN B-AC
+, PUNCT O
+third ADJ B-LF
+larval ADJ I-LF
+stage NOUN I-LF
+; PUNCT O
+Mmp1 PROPN B-AC
+, PUNCT O
+Matrix PROPN B-LF
+metalloprotease NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+RNAi PROPN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT O
+rnts PROPN B-AC
+, PUNCT O
+rotund NOUN O
+- PUNCT O
+GAL4 PROPN O
+, PUNCT O
+tubulin NOUN O
+- PUNCT O
+GAL80thermo NOUN O
+- PUNCT O
+sensitive ADJ O
+; PUNCT O
+R0 PROPN B-AC
+, PUNCT O
+beginning NOUN B-LF
+of ADP I-LF
+the DET I-LF
+recovery NOUN I-LF
+period NOUN I-LF
+; PUNCT O
+vol NOUN B-AC
+, PUNCT O
+volume NOUN B-LF
+; PUNCT O
+Wg PROPN B-AC
+, PUNCT O
+Wingless PROPN B-LF
+; PUNCT O
+yw NOUN B-AC
+, PUNCT O
+yellow ADJ B-LF
+, PUNCT I-LF
+white ADJ I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+ddPCR NOUN O
+, PUNCT O
+droplet NOUN O
+digital ADJ O
+PCR NOUN O
+; PUNCT O
+preBötC NOUN B-AC
+, PUNCT O
+pre ADJ B-LF
+- ADJ I-LF
+Bötzinger ADJ I-LF
+complex NOUN I-LF
+; PUNCT O
+shRNA NOUN B-AC
+, PUNCT O
+short ADJ B-LF
+hairpin NOUN I-LF
+RNA NOUN I-LF
+; PUNCT O
+Trp NOUN B-AC
+, PUNCT O
+transient ADJ B-LF
+receptor NOUN I-LF
+potential NOUN I-LF
+. PUNCT O
+
+For ADP O
+underlying VERB O
+data NOUN O
+, PUNCT O
+see VERB O
+S1 PROPN O
+Data PROPN O
+file NOUN O
+. PUNCT O
+α PROPN B-AC
+- PUNCT B-AC
+SMA PROPN B-AC
+, PUNCT O
+alpha ADJ B-LF
+- PUNCT I-LF
+smooth ADJ I-LF
+muscle NOUN I-LF
+actin NOUN I-LF
+; PUNCT O
+CCl4 PROPN B-AC
+, PUNCT O
+carbon NOUN B-LF
+tetrachloride NOUN I-LF
+; PUNCT O
+cIAP PROPN B-AC
+, PUNCT O
+cellular ADJ B-LF
+inhibitor NOUN I-LF
+of ADP I-LF
+apoptosis NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+Hgf PROPN B-AC
+, PUNCT O
+hepatocyte NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+; PUNCT O
+med23 NOUN O
+, PUNCT O
+Mediator PROPN O
+complex NOUN O
+subunit NOUN O
+23 NUM O
+; PUNCT O
+med23Δli NOUN B-AC
+, PUNCT O
+liver NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+knockout NOUN I-LF
+of ADP I-LF
+Med23 PROPN I-LF
+; PUNCT O
+med23f NOUN B-AC
+/ SYM B-AC
+f NOUN B-AC
+, PUNCT O
+med23 NOUN B-LF
+- PUNCT I-LF
+floxed VERB I-LF
+; PUNCT O
+PCNA PROPN B-AC
+, PUNCT O
+proliferating VERB B-LF
+cell NOUN I-LF
+nuclear ADJ I-LF
+antigen NOUN I-LF
+; PUNCT O
+qRT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+, PUNCT O
+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+PCR NOUN I-LF
+. PUNCT O
+
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+His2Av PROPN B-AC
+, PUNCT O
+histone NOUN B-LF
+2A NOUN I-LF
+variant NOUN I-LF
+; PUNCT O
+MTB PROPN O
+, PUNCT O
+mid NOUN O
+- NOUN O
+blastula NOUN O
+transition NOUN O
+; PUNCT O
+RFP PROPN B-AC
+, PUNCT O
+red ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+Rif1 PROPN B-AC
+, PUNCT O
+Rap1 NOUN O
+interacting VERB O
+factor NOUN O
+. PUNCT O
+
+Kinesin PROPN B-LF
+family NOUN I-LF
+member NOUN I-LF
+20A PROPN I-LF
+( PUNCT O
+KIF20A PROPN B-AC
+, PUNCT O
+also ADV O
+known VERB O
+as ADP O
+RAB6KIFL PROPN O
+) PUNCT O
+belongs VERB O
+to ADP O
+kinesin PROPN O
+superfamily-6 NOUN O
+and CCONJ O
+contains VERB O
+a DET O
+conserved ADJ O
+motor NOUN O
+domain NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+IQR PROPN B-AC
+, PUNCT O
+interquartile ADJ B-LF
+range NOUN I-LF
+; PUNCT O
+MCW PROPN O
+, PUNCT O
+married ADJ O
+, PUNCT O
+cohabitating VERB O
+, PUNCT O
+widowed VERB O
+; PUNCT O
+PedsQL PROPN O
+, PUNCT O
+Pediatric PROPN O
+Quality PROPN O
+of ADP O
+Life PROPN O
+Inventory PROPN O
+; PUNCT O
+SES PROPN B-AC
+, PUNCT O
+socioeconomic ADJ B-LF
+status NOUN I-LF
+; PUNCT O
+SO PROPN O
+, PUNCT O
+single ADJ O
+, PUNCT O
+other ADJ O
+; PUNCT O
+SRH PROPN B-AC
+, PUNCT O
+sexual ADJ B-LF
+and CCONJ I-LF
+reproductive ADJ I-LF
+health NOUN I-LF
+. PUNCT O
+
+F PROPN B-AC
+- PUNCT B-AC
+actin NOUN B-AC
+, PUNCT O
+filamentous ADJ B-LF
+actin NOUN I-LF
+; PUNCT O
+HEK PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+embryonic ADJ I-LF
+kidney NOUN I-LF
+; PUNCT O
+MBP PROPN B-AC
+, PUNCT O
+maltose NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+; PUNCT O
+pel NOUN O
+, PUNCT O
+pellet NOUN O
+; PUNCT O
+sup NOUN O
+, PUNCT O
+supernatant NOUN O
+; PUNCT O
+TccC3HVR PROPN B-AC
+, PUNCT O
+hypervariable ADJ B-LF
+region NOUN I-LF
+of ADP I-LF
+TccC3 PROPN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Two NUM O
+developments NOUN O
+facilitated VERB O
+the DET O
+shift NOUN O
+to ADP O
+the DET O
+outpatient NOUN O
+model NOUN O
+: PUNCT O
+first ADV O
+, PUNCT O
+the DET O
+introduction NOUN O
+of ADP O
+mid ADJ B-LF
+- PUNCT I-LF
+upper ADJ I-LF
+arm NOUN I-LF
+circumference NOUN I-LF
+( PUNCT O
+MUAC PROPN B-AC
+) PUNCT O
+as ADP O
+an DET O
+additional ADJ O
+diagnostic ADJ O
+tool NOUN O
+; PUNCT O
+this DET O
+change NOUN O
+made VERB O
+case NOUN O
+detection NOUN O
+by ADP O
+CHWs PROPN B-AC
+more ADV O
+convenient ADJ O
+and CCONJ O
+affordable ADJ O
+than ADP O
+using VERB O
+weight NOUN B-LF
+- PUNCT I-LF
+for ADP I-LF
+- PUNCT I-LF
+length NOUN I-LF
+Z NOUN I-LF
+- PUNCT I-LF
+scores NOUN I-LF
+( PUNCT O
+WLZs PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+require VERB O
+the DET O
+measurement NOUN O
+of ADP O
+both CCONJ O
+weight NOUN O
+and CCONJ O
+length NOUN O
+. PUNCT O
+
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+OR PROPN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+AW PROPN B-AC
+, PUNCT O
+active ADJ B-LF
+wake NOUN I-LF
+; PUNCT O
+cMC NOUN B-AC
+, PUNCT O
+caudal ADJ B-LF
+medial ADJ I-LF
+cortex NOUN I-LF
+; PUNCT O
+ECG PROPN B-AC
+, PUNCT O
+electrocardiogram NOUN B-LF
+; PUNCT O
+EMG PROPN B-AC
+, PUNCT O
+electromyogram NOUN B-LF
+; PUNCT O
+EOG PROPN B-AC
+, PUNCT O
+electro NOUN B-LF
+- NOUN I-LF
+oculogram NOUN I-LF
+; PUNCT O
+LFP PROPN B-AC
+, PUNCT O
+local ADJ B-LF
+field NOUN I-LF
+potential NOUN I-LF
+; PUNCT O
+QW PROPN B-AC
+, PUNCT O
+quiet ADJ B-LF
+wake NOUN I-LF
+. PUNCT O
+
+EEA1 PROPN B-AC
+, PUNCT O
+early ADJ B-LF
+endosome NOUN I-LF
+antigen NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+FCHSD2 PROPN B-AC
+, PUNCT O
+FCH PROPN B-LF
+/ SYM I-LF
+F PROPN I-LF
+- PUNCT I-LF
+BAR PROPN I-LF
+and CCONJ I-LF
+Double PROPN I-LF
+SH3 PROPN I-LF
+Domain PROPN I-LF
+- PUNCT I-LF
+Containing PROPN I-LF
+Protein PROPN I-LF
+; PUNCT O
+LAMP1 PROPN B-AC
+, PUNCT O
+lysosome NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+membrane NOUN I-LF
+glycoprotein NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+MET PROPN B-AC
+, PUNCT O
+proto NOUN B-LF
+- PUNCT I-LF
+oncogene NOUN I-LF
+c NOUN I-LF
+- PUNCT I-LF
+Met PROPN I-LF
+; PUNCT O
+siCtrl PROPN O
+, PUNCT O
+control NOUN O
+siRNA NOUN B-AC
+; PUNCT O
+siRNA NOUN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+. PUNCT O
+
+We PRON O
+carried VERB O
+out ADP O
+systematic ADJ O
+experiments NOUN O
+to PART O
+determine VERB O
+if SCONJ O
+the DET O
+peptide NOUN O
+detergents NOUN O
+A6 PROPN B-AC
+K PROPN B-AC
+( PUNCT O
+molecular ADJ O
+weight NOUN O
+= PUNCT O
+615 NUM O
+Da NOUN O
+, PUNCT O
+CAC NOUN B-AC
+= PUNCT O
+1.6 NUM O
+mM NOUN O
+in ADP O
+water NOUN O
+, PUNCT O
+approximately ADV O
+0.23 NUM O
+mM NOUN O
+in ADP O
+phosphate NOUN B-LF
+- PUNCT I-LF
+buffered VERB I-LF
+saline NOUN I-LF
+[ PUNCT O
+PBS PROPN B-AC
+] PUNCT O
+) PUNCT O
+and CCONJ O
+acetyl NOUN B-LF
+- PUNCT I-LF
+VVVVVVD NOUN I-LF
+( PUNCT O
+V6D PROPN B-AC
+) PUNCT O
+( PUNCT O
+molecular ADJ O
+weight NOUN O
+= PUNCT O
+783 NUM O
+Da NOUN O
+, PUNCT O
+CAC NOUN B-AC
+= PUNCT O
+0.7 NUM O
+mM NOUN O
+in ADP O
+water NOUN O
+, PUNCT O
+approximately ADV O
+0.1 NUM O
+mM NOUN O
+in ADP O
+PBS PROPN B-AC
+) PUNCT O
+could AUX O
+stabilize VERB O
+PS PROPN B-AC
+- PUNCT B-AC
+I PROPN B-AC
+complex NOUN O
+during ADP O
+the DET O
+drying VERB O
+process NOUN O
+. PUNCT O
+
+The DET O
+XRD NOUN O
+scan NOUN O
+of ADP O
+the DET O
+synthesized VERB O
+AuNPs PROPN B-AC
+showed VERB O
+a DET O
+significant ADJ O
+diffraction NOUN O
+peak NOUN O
+at ADP O
+2θ NOUN O
+angle NOUN O
+: PUNCT O
+38.1 NUM O
+° NOUN O
+corresponding VERB O
+to ADP O
+111crystal NOUN O
+plane NOUN O
+of ADP O
+face NOUN O
+- PUNCT O
+centered VERB O
+gold NOUN O
+in ADP O
+the DET O
+nanoparticles NOUN B-LF
+solution NOUN O
+made VERB O
+from ADP O
+metabolites NOUN O
+extracted VERB O
+from ADP O
+mammalian ADJ O
+cells NOUN O
+( PUNCT O
+AuNP2 PROPN O
+and CCONJ O
+AuNP4 PROPN O
+) PUNCT O
+, PUNCT O
+but CCONJ O
+not PART O
+from ADP O
+metabolites NOUN O
+solution NOUN O
+extracted VERB O
+from ADP O
+cell NOUN O
+- PUNCT O
+free ADJ O
+supernatants NOUN O
+or CCONJ O
+PBS PROPN O
+solution NOUN O
+, PUNCT O
+employed VERB O
+as ADP O
+control NOUN O
+( PUNCT O
+Fig NOUN O
+4A NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+formation NOUN O
+of ADP O
+AuNPs PROPN B-AC
+was AUX O
+confirmed VERB O
+by ADP O
+the DET O
+energy NOUN O
+dispersive ADJ O
+spectroscopy NOUN O
+( PUNCT O
+EDS PROPN O
+) PUNCT O
+( PUNCT O
+Fig NOUN O
+4B NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+EDS PROPN O
+profile NOUN O
+showed VERB O
+a DET O
+strong ADJ O
+Au3 NOUN O
++ NOUN O
+signal NOUN O
+from ADP O
+the DET O
+NPs PROPN B-AC
+solution NOUN O
+made VERB O
+from ADP O
+the DET O
+metabolites NOUN O
+extracted VERB O
+from ADP O
+mammalian ADJ O
+cells NOUN O
+. PUNCT O
+
+However ADV O
+, PUNCT O
+EUS PROPN B-AC
+is AUX O
+a DET O
+tedious ADJ O
+procedure NOUN O
+, PUNCT O
+with ADP O
+poor ADJ O
+image NOUN O
+and CCONJ O
+inter ADJ O
+- PUNCT O
+observer ADJ O
+variation NOUN O
+for ADP O
+the DET O
+staging NOUN O
+of ADP O
+EGC PROPN B-AC
+, PUNCT O
+compared VERB O
+with ADP O
+conventional ADJ O
+white ADJ B-LF
+- PUNCT I-LF
+light NOUN I-LF
+endoscopy NOUN I-LF
+( PUNCT O
+WLE PROPN B-AC
+) PUNCT O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+UPRmt NOUN B-AC
+, PUNCT O
+mitochondrial ADJ O
+unfolded VERB B-LF
+protein NOUN I-LF
+response NOUN I-LF
+. PUNCT O
+
+Samples NOUN O
+were AUX O
+analyzed VERB O
+for ADP O
+serum ADJ O
+β ADJ B-LF
+- ADJ I-LF
+aminoisobutyric ADJ I-LF
+acid NOUN I-LF
+( PUNCT O
+BAIB NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+urine NOUN O
+for ADP O
+cystatin NOUN O
+B NOUN O
+and CCONJ O
+clusterin NOUN O
+. PUNCT O
+
+The DET O
+decolorization NOUN O
+of ADP O
+azobenzene NOUN O
+( PUNCT O
+AZ PROPN B-AC
+) PUNCT O
+and CCONJ O
+azo NOUN O
+dyes NOUN O
+( PUNCT O
+RR241 NOUN O
+, PUNCT O
+methyl NOUN B-LF
+red NOUN I-LF
+( PUNCT O
+MR PROPN B-AC
+) PUNCT O
+and CCONJ O
+congo NOUN B-LF
+red NOUN I-LF
+( PUNCT O
+CR NOUN B-AC
+) PUNCT O
+by ADP O
+the DET O
+purified VERB O
+enzyme NOUN O
+was AUX O
+investigated VERB O
+under ADP O
+varying VERB O
+conditions NOUN O
+. PUNCT O
+
+Values NOUN O
+for ADP O
+each DET O
+data NOUN O
+point NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+3 NUM B-AC
+M NOUN B-AC
+, PUNCT O
+3 NUM B-LF
+months NOUN I-LF
+old ADJ I-LF
+; PUNCT O
+26 NUM B-AC
+M NOUN B-AC
+, PUNCT O
+26 NUM B-LF
+months NOUN I-LF
+old ADJ I-LF
+; PUNCT O
+AV PROPN O
+, PUNCT O
+atrioventricular ADJ O
+; PUNCT O
+Cisd2 PROPN O
+, PUNCT O
+CDGSH PROPN O
+iron NOUN O
+- PUNCT O
+sulfur NOUN O
+domain NOUN O
+- PUNCT O
+containing VERB O
+protein NOUN O
+2 NUM O
+; PUNCT O
+Cx43 PROPN B-AC
+, PUNCT O
+Connexin PROPN B-LF
+43 NUM I-LF
+; PUNCT O
+DCF PROPN B-AC
+, PUNCT O
+2′ NUM B-LF
+, PUNCT I-LF
+7′-dichlorofluorescein NOUN I-LF
+; PUNCT O
+ECG PROPN B-AC
+, PUNCT O
+electrocardiography NOUN B-LF
+; PUNCT O
+Gapdh PROPN B-AC
+, PUNCT O
+glyceraldehyde NOUN B-LF
+3 NUM I-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+; PUNCT O
+IF PROPN B-AC
+, PUNCT O
+immunofluorescence NOUN B-LF
+; PUNCT O
+LV PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricle NOUN I-LF
+; PUNCT O
+MRI PROPN B-AC
+, PUNCT O
+magnetic ADJ O
+resonance NOUN O
+image NOUN O
+; PUNCT O
+RNS PROPN B-AC
+, PUNCT O
+reactive ADJ B-LF
+nitrogen NOUN I-LF
+species NOUN I-LF
+; PUNCT O
+ROS PROPN B-AC
+, PUNCT O
+reactive ADJ B-LF
+oxygen NOUN I-LF
+species NOUN I-LF
+; PUNCT O
+Serca2a PROPN B-AC
+, PUNCT O
+sarco NOUN B-LF
+/ SYM I-LF
+endoplasmic ADJ I-LF
+reticulum NOUN I-LF
+Ca2 NOUN I-LF
++ NOUN I-LF
+-ATPase NOUN I-LF
+; PUNCT O
+TBQ PROPN B-AC
+, PUNCT O
+2,5 NUM B-LF
+- PUNCT I-LF
+Di NOUN I-LF
+- PUNCT I-LF
+tert NOUN I-LF
+- PUNCT I-LF
+butylhydroquinone NOUN I-LF
+; PUNCT O
+TEM PROPN B-AC
+, PUNCT O
+transmission NOUN B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+; PUNCT O
+TG PROPN B-AC
+, PUNCT O
+transgenic ADJ B-LF
+; PUNCT O
+WGA PROPN O
+, PUNCT O
+wheat NOUN O
+germ NOUN O
+agglutinin NOUN O
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+type NOUN I-LF
+. PUNCT O
+
+Principal ADJ B-LF
+coordinate NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+PCoA PROPN B-AC
+) PUNCT O
+plots NOUN O
+for ADP O
+unweighted ADJ O
+UniFrac PROPN O
+distances NOUN O
+and CCONJ O
+Bray PROPN O
+Curtis PROPN O
+dissimilarities NOUN O
+were AUX O
+generated VERB O
+with ADP O
+QIIME2 PROPN O
+. PUNCT O
+The DET O
+ANOSIM PROPN B-AC
+( PUNCT O
+Analysis PROPN B-LF
+of ADP I-LF
+Similarity PROPN I-LF
+) PUNCT O
+test NOUN O
+within ADP O
+PRIMER PROPN O
+6 NUM O
+software NOUN O
+package NOUN O
+( PUNCT O
+PRIMER PROPN O
+- PUNCT O
+E PROPN O
+Ltd. PROPN O
+, PUNCT O
+Luton PROPN O
+, PUNCT O
+UK PROPN O
+) PUNCT O
+was AUX O
+performed VERB O
+on ADP O
+the DET O
+weighted ADJ O
+and CCONJ O
+unweighted ADJ O
+UniFrac PROPN O
+and CCONJ O
+Bray PROPN O
+Curtis PROPN O
+distance NOUN O
+metrics NOUN O
+to PART O
+find VERB O
+significant ADJ O
+differences NOUN O
+in ADP O
+microbial ADJ O
+communities NOUN O
+between ADP O
+groups NOUN O
+. PUNCT O
+
+Significantly ADV O
+, PUNCT O
+gp95 PROPN O
+’s PART O
+stimulation NOUN O
+of ADP O
+NMDARs NOUN B-AC
+activates VERB O
+cGMP NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+II NUM I-LF
+( PUNCT O
+cGKII PROPN B-AC
+) PUNCT O
+through ADP O
+the DET O
+activation NOUN O
+of ADP O
+the DET O
+neuronal ADJ B-LF
+nitric NOUN I-LF
+oxide NOUN I-LF
+synthase NOUN I-LF
+( PUNCT O
+nNOS)-cGMP NOUN B-AC
+pathway NOUN O
+, PUNCT O
+which PRON O
+increases VERB O
+Ca2 NOUN O
++ NOUN O
+release NOUN O
+from ADP O
+the DET O
+ER NOUN B-AC
+and CCONJ O
+promotes VERB O
+surface NOUN O
+expression NOUN O
+of ADP O
+AMPA PROPN O
+receptors NOUN O
+, PUNCT O
+leading VERB O
+to ADP O
+an DET O
+increase NOUN O
+in ADP O
+synaptic ADJ O
+activity NOUN O
+. PUNCT O
+
+As SCONJ O
+shown VERB O
+in ADP O
+Fig NOUN O
+1 NUM O
+( PUNCT O
+and CCONJ O
+in ADP O
+S1 PROPN O
+Table PROPN O
+) PUNCT O
+, PUNCT O
+these PRON O
+included VERB O
+plasma NOUN O
+IgA PROPN O
+anti ADJ O
+- PUNCT O
+LPS PROPN B-AC
+antibody NOUN O
+, PUNCT O
+zonulin NOUN O
+( PUNCT O
+in ADP O
+all DET O
+children NOUN O
+for ADP O
+WAZ PROPN B-AC
+and CCONJ O
+, PUNCT O
+for ADP O
+HAZ PROPN B-AC
+in ADP O
+children NOUN O
+> NUM O
+12 NUM O
+months NOUN O
+old ADJ O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+I PROPN B-AC
+- PUNCT B-AC
+FABP PROPN B-AC
+. PUNCT O
+IgA PROPN O
+anti ADJ O
+- PUNCT O
+flagellin ADJ O
+and CCONJ O
+anti ADJ O
+- PUNCT O
+LPS PROPN B-AC
+antibodies NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+292 NUM O
+; PUNCT O
+r NOUN O
+= SYM O
+0.15 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.011 NUM O
+and CCONJ O
+r NOUN O
+= SYM O
+0.14 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.017 NUM O
+) PUNCT O
+as ADP O
+well ADV O
+as ADP O
+intestinal ADJ B-LF
+fatty NOUN I-LF
+acid NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+( PUNCT O
+I PROPN B-AC
+- PUNCT B-AC
+FABP PROPN B-AC
+; PUNCT O
+n NOUN O
+= SYM O
+281 NUM O
+; PUNCT O
+r NOUN O
+= SYM O
+0.14 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.024 NUM O
+) PUNCT O
+associate VERB O
+with ADP O
+worse ADJ O
+stunting NOUN O
+( PUNCT O
+i.e. X O
+lower ADJ O
+HAZ PROPN B-AC
+SS PROPN O
+scores NOUN O
+) PUNCT O
+at ADP O
+the DET O
+time NOUN O
+of ADP O
+enrollment NOUN O
+, PUNCT O
+suggesting VERB O
+greater ADJ O
+prior ADJ O
+exposure NOUN O
+to ADP O
+LPS PROPN B-AC
+and CCONJ O
+release NOUN O
+of ADP O
+an DET O
+intestinal ADJ O
+cytosolic ADJ O
+protein NOUN O
+, PUNCT O
+thus ADV O
+enterocyte NOUN O
+damage NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+While SCONJ O
+using VERB O
+fluorescence NOUN B-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+( PUNCT O
+FISH PROPN B-AC
+) PUNCT O
+to PART O
+visualize VERB O
+the DET O
+Xic NOUN B-AC
+in ADP O
+female ADJ O
+ES NOUN B-AC
+cells NOUN O
+fixed VERB O
+with ADP O
+paraformaldehyde NOUN B-LF
+( PUNCT O
+PFA PROPN B-AC
+) PUNCT O
+, PUNCT O
+we PRON O
+observed VERB O
+that SCONJ O
+a DET O
+high ADJ O
+frequency NOUN O
+of ADP O
+cells NOUN O
+displayed VERB O
+a DET O
+single ADJ O
+pinpoint NOUN O
+FISH PROPN B-AC
+signal NOUN O
+at ADP O
+one NUM O
+allele NOUN O
+and CCONJ O
+a DET O
+double ADJ O
+pinpoint NOUN O
+at ADP O
+the DET O
+other ADJ O
+. PUNCT O
+
+In ADP O
+the DET O
+foreseeable ADJ O
+future NOUN O
+, PUNCT O
+patients NOUN O
+with ADP O
+hepatitis PROPN B-LF
+C PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+HCV PROPN B-AC
+) PUNCT O
+with ADP O
+good ADJ O
+healthcare NOUN O
+access NOUN O
+will AUX O
+all PRON O
+have AUX O
+been AUX O
+cured VERB O
+and CCONJ O
+the DET O
+lost VERB B-LF
+to PART I-LF
+follow VERB I-LF
+- PUNCT I-LF
+up ADP I-LF
+( PUNCT O
+LFU PROPN B-AC
+) PUNCT O
+HCV PROPN B-AC
+- PUNCT O
+population NOUN O
+will AUX O
+increasingly ADV O
+exist VERB O
+of ADP O
+hard ADJ O
+- PUNCT O
+to PART O
+- PUNCT O
+reach VERB O
+patients NOUN O
+. PUNCT O
+
+The DET O
+most ADV O
+recent ADJ O
+IA PROPN B-AC
+- PUNCT O
+based VERB O
+challenge NOUN O
+by ADP O
+a DET O
+tobacco NOUN O
+company NOUN O
+( PUNCT O
+of ADP O
+which PRON O
+we PRON O
+are AUX O
+aware ADJ O
+) PUNCT O
+was AUX O
+to PART O
+write VERB O
+to PART O
+the DET O
+Chairman PROPN O
+of ADP O
+the DET O
+European PROPN O
+Commission PROPN O
+'s PART O
+internal ADJ O
+Impact PROPN B-LF
+Assessment PROPN I-LF
+Board PROPN O
+in ADP O
+July PROPN O
+2008 NUM O
+to PART O
+complain VERB O
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+- PUNCT O
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+Cardiovascular ADJ O
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+most ADV O
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+- PUNCT I-LF
+income NOUN I-LF
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+( PUNCT O
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+) PUNCT O
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+We PRON O
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+The DET O
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+( PUNCT O
+ROC PROPN B-AC
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+In ADP O
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+( PUNCT O
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+Recent ADJ O
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+( PUNCT O
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+- PUNCT B-AC
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+SDF NOUN B-AC
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+. PUNCT O
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+In ADP O
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+one NUM O
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+( PUNCT O
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+
+BMI NOUN B-AC
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+
+The DET O
+angiomotin PROPN B-LF
+( PUNCT O
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+- PUNCT I-LF
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+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
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+) PUNCT O
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+role NOUN O
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+the DET O
+inhibition NOUN O
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+Importantly ADV O
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+the DET O
+Western ADJ O
+cohort NOUN O
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+metabolic ADJ O
+health NOUN O
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+( PUNCT O
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+) PUNCT O
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+9 NUM O
+, PUNCT O
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+] PUNCT O
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+The DET O
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+curve NOUN I-LF
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+( PUNCT O
+RE PROPN B-AC
+) PUNCT O
+at ADP O
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+time NOUN O
+- ADJ O
+point NOUN O
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+DCE PROPN B-AC
+- ADJ B-AC
+MRI NOUN B-AC
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+RE PROPN B-AC
+at ADP O
+a DET O
+given VERB O
+time NOUN O
+- ADJ O
+point NOUN O
+is AUX O
+defined VERB O
+as ADP O
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+- ADJ O
+SI0)/SI0×100%(1 NUM O
+) PUNCT O
+where SCONJ O
+SI0 PROPN O
+is AUX O
+the DET O
+average ADJ O
+pre ADJ O
+- ADJ O
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+signal NOUN O
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+and CCONJ O
+SIt PROPN O
+is AUX O
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+MR PROPN B-AC
+signal NOUN O
+intensity NOUN O
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+time NOUN O
+t. PUNCT O
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+Fragments NOUN B-LF
+per ADP I-LF
+kilobase NOUN I-LF
+of ADP I-LF
+transcript NOUN I-LF
+per ADP I-LF
+million NUM I-LF
+mapped VERB I-LF
+reads NOUN I-LF
+( PUNCT O
+FPKMs PROPN B-AC
+) PUNCT O
+expression NOUN O
+data NOUN O
+of ADP O
+miRNA NOUN O
+targets NOUN O
+were AUX O
+generated VERB O
+from ADP O
+our PRON O
+previous ADJ O
+study NOUN O
+using VERB O
+RNA NOUN O
+sequencing NOUN O
+[ PUNCT O
+52 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+this DET O
+current ADJ O
+study NOUN O
+, PUNCT O
+we PRON O
+developed VERB O
+a DET O
+novel ADJ O
+high ADJ O
+- PUNCT O
+throughput NOUN O
+platform NOUN O
+for ADP O
+quantifying VERB O
+FGF23 NOUN B-AC
+, PUNCT O
+used VERB O
+a DET O
+clinically ADV O
+utilised VERB O
+platform NOUN O
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+N NOUN B-LF
+- PUNCT I-LF
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+- PUNCT I-LF
+B NOUN I-LF
+- PUNCT I-LF
+type NOUN I-LF
+natriuretic ADJ I-LF
+peptide NOUN I-LF
+( PUNCT O
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+- PUNCT B-AC
+proBNP NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+quantified VERB O
+these DET O
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+the DET O
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+tested VERB O
+patients NOUN O
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+as ADP O
+in ADP O
+an DET O
+unselected ADJ O
+independent ADJ O
+cohort NOUN O
+of ADP O
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+to ADP O
+hospital NOUN O
+, PUNCT O
+for ADP O
+validation NOUN O
+. PUNCT O
+
+We PRON O
+tested VERB O
+for ADP O
+an DET O
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+of ADP O
+the DET O
+proportion NOUN O
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+species NOUN O
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+a DET O
+clade NOUN O
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+breed VERB O
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+tropics NOUN O
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+- PUNCT O
+regime NOUN O
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+( PUNCT O
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+R PROPN O
+package NOUN O
+caper NOUN O
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+89 NUM O
+] PUNCT O
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+signal NOUN O
+( PUNCT O
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+) PUNCT O
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+optimization NOUN O
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+0 NUM O
+≤ SYM O
+λ NOUN O
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+1 NUM O
+. PUNCT O
+
+Stocks NOUN O
+of ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+Smith PROPN O
+Strain PROPN O
+MCMV PROPN B-AC
+salivary ADJ O
+gland NOUN O
+extracts NOUN O
+[ X O
+14 NUM O
+] PUNCT O
+and CCONJ O
+bacterial ADJ B-LF
+artificial ADJ I-LF
+chromosome NOUN I-LF
+( PUNCT O
+BAC)-derived PROPN B-AC
+wild ADJ O
+- PUNCT O
+type NOUN O
+, PUNCT O
+DN PROPN O
+- PUNCT O
+SCP PROPN O
+- PUNCT O
+MCMV PROPN B-AC
+[ X O
+44 NUM O
+] PUNCT O
+, PUNCT O
+Δm157 NOUN O
+- PUNCT O
+MCMV PROPN B-AC
+, PUNCT O
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+- PUNCT O
+revertant NOUN O
+were AUX O
+prepared VERB O
+as SCONJ O
+previously ADV O
+described VERB O
+[ X O
+73 NUM O
+] PUNCT O
+. PUNCT O
+
+DIC PROPN B-AC
+, PUNCT O
+differential ADJ B-LF
+interference NOUN I-LF
+contrast NOUN I-LF
+; PUNCT O
+FUS PROPN B-AC
+, PUNCT O
+Fused VERB B-LF
+in ADP I-LF
+sarcoma NOUN I-LF
+. PUNCT O
+
+Pro ADJ O
+- NOUN O
+inflammatory ADJ O
+cytokines NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+TNF NOUN B-AC
+- NOUN O
+α NOUN O
+and CCONJ O
+IL-6 NOUN B-AC
+, PUNCT O
+have AUX O
+been AUX O
+shown VERB O
+to PART O
+increase VERB O
+in ADP O
+the DET O
+liver NOUN O
+of ADP O
+carbon NOUN B-LF
+tetrachloride NOUN I-LF
+( PUNCT O
+CCl4)-induced NOUN B-AC
+hepatitis NOUN O
+[ PUNCT O
+13 NUM O
+] PUNCT O
+. PUNCT O
+
+CSF PROPN O
+, PUNCT O
+cerebrospinal ADJ O
+fluid NOUN O
+; PUNCT O
+HLA PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+leucocyte NOUN I-LF
+antigen NOUN I-LF
+. PUNCT O
+
+Kidney NOUN O
+function NOUN O
+was AUX O
+assessed VERB O
+using VERB O
+point NOUN B-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+care NOUN I-LF
+( PUNCT O
+POC PROPN B-AC
+) PUNCT O
+tests NOUN O
+that PRON O
+included VERB O
+a DET O
+test NOUN O
+strip NOUN O
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+measuring VERB O
+creatinine NOUN O
+level NOUN O
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+the DET O
+blood NOUN O
+using VERB O
+a DET O
+portable ADJ O
+device NOUN O
+and CCONJ O
+a DET O
+urine NOUN O
+dipstick NOUN O
+test NOUN O
+to PART O
+evaluate VERB O
+for ADP O
+proteinuria NOUN O
+. PUNCT O
+
+We PRON O
+studied VERB O
+the DET O
+effects NOUN O
+of ADP O
+vernalization NOUN O
+, PUNCT O
+ambient ADJ O
+growth NOUN O
+temperature NOUN O
+, PUNCT O
+and CCONJ O
+photoperiod NOUN O
+, PUNCT O
+using VERB O
+four NUM O
+different ADJ O
+environments NOUN O
+: PUNCT O
+23 NUM B-LF
+° NOUN I-LF
+C NOUN I-LF
+long ADJ I-LF
+days NOUN I-LF
+( PUNCT O
+23LD NUM B-AC
+) PUNCT O
+, PUNCT O
+16 NUM B-LF
+° NOUN I-LF
+C NOUN I-LF
+long ADJ I-LF
+days NOUN I-LF
+( PUNCT O
+16LD NUM B-AC
+) PUNCT O
+, PUNCT O
+16 NUM B-LF
+° NOUN I-LF
+C NOUN I-LF
+long ADJ I-LF
+days NOUN I-LF
+after ADP I-LF
+5 NUM I-LF
+wk NOUN I-LF
+vernalization NOUN I-LF
+( PUNCT O
+16LDV NOUN B-AC
+) PUNCT O
+, PUNCT O
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+23 NUM B-LF
+° NOUN I-LF
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+short ADJ I-LF
+days NOUN I-LF
+( PUNCT O
+23SD NUM B-AC
+) PUNCT O
+. PUNCT O
+DTF PROPN B-AC
+and CCONJ O
+TLN PROPN O
+data NOUN O
+from ADP O
+155 NUM O
+wild ADJ O
+strains NOUN O
+, PUNCT O
+along ADP O
+with ADP O
+the DET O
+common ADJ O
+laboratory NOUN O
+strains NOUN O
+Col-0 PROPN B-AC
+and CCONJ O
+Ler PROPN B-AC
+and CCONJ O
+32 NUM O
+flowering ADJ O
+time NOUN O
+mutants NOUN O
+in ADP O
+Col-0 PROPN B-AC
+or CCONJ O
+Ler PROPN B-AC
+backgrounds NOUN O
+, PUNCT O
+passed VERB O
+our PRON O
+quality NOUN O
+controls NOUN O
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+at ADV O
+least ADV O
+two NUM O
+conditions NOUN O
+. PUNCT O
+
+Aussie PROPN B-AC
+- PUNCT B-AC
+FIT PROPN B-AC
+, PUNCT O
+Australian ADJ B-LF
+Fans NOUN I-LF
+in ADP I-LF
+Training NOUN I-LF
+; PUNCT O
+CONSORT PROPN B-AC
+, PUNCT O
+Consolidated VERB B-LF
+Standards NOUN I-LF
+of ADP I-LF
+Reporting NOUN I-LF
+Trials NOUN I-LF
+. PUNCT O
+
+EIA NOUN B-AC
+- NOUN O
+positive ADJ O
+samples NOUN O
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+cultured VERB O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+and CCONJ O
+C. NOUN O
+difficile ADJ O
+isolates NOUN O
+genotyped VERB O
+by ADP O
+multi ADJ B-LF
+- NOUN I-LF
+locus NOUN I-LF
+sequence NOUN I-LF
+typing NOUN I-LF
+( PUNCT O
+MLST NOUN B-AC
+) PUNCT O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+. PUNCT O
+
+Here ADV O
+we PRON O
+sought VERB O
+to PART O
+validate VERB O
+the DET O
+glycoforms NOUN O
+as ADP O
+a DET O
+biomarker NOUN O
+of ADP O
+mucinous ADJ O
+cysts NOUN O
+and CCONJ O
+to PART O
+specify VERB O
+the DET O
+oligosaccharide NOUN O
+linkages NOUN O
+that SCONJ O
+characterize VERB O
+MUC5AC PROPN O
+. PUNCT O
+We PRON O
+hypothesized VERB O
+that SCONJ O
+mucinous ADJ O
+cysts NOUN O
+secrete VERB O
+MUC5AC PROPN O
+displaying VERB O
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+N NOUN B-LF
+- NOUN I-LF
+acetylglucosamine NOUN I-LF
+( PUNCT O
+GlcNAc PROPN B-AC
+) PUNCT O
+in ADP O
+either CCONJ O
+alpha NOUN O
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+beta NOUN O
+linkage NOUN O
+. PUNCT O
+
+YACs NOUN B-AC
+were AUX O
+retrofitted VERB O
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+artificial ADJ I-LF
+chromosomes NOUN I-LF
+( PUNCT O
+BACs PROPN B-AC
+) PUNCT O
+by ADP O
+homologous ADJ O
+recombination NOUN O
+in ADP O
+yeast NOUN O
+using VERB O
+a DET O
+BAC PROPN B-AC
+/ SYM O
+NeoR PROPN O
+retrofitting VERB O
+vector NOUN O
+, PUNCT O
+BRV1 PROPN O
+, PUNCT O
+and CCONJ O
+then ADV O
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+DH10B PROPN O
+E. PROPN O
+coli PROPN O
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+( PUNCT O
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+and CCONJ O
+Larionov PROPN O
+1999 NUM O
+) PUNCT O
+. PUNCT O
+
+HFpEF PROPN B-AC
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+, PUNCT O
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+ventricular ADJ I-LF
+( PUNCT O
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+) PUNCT O
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+impairment NOUN O
+, PUNCT O
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+filling NOUN O
+pressures NOUN O
+. PUNCT O
+
+BMDM PROPN B-AC
+, PUNCT O
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+– PUNCT I-LF
+derived VERB I-LF
+MΦ PROPN I-LF
+; PUNCT O
+HS PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+salt NOUN I-LF
+; PUNCT O
+MΦ PROPN B-AC
+, PUNCT O
+monocyte NOUN B-LF
+/ SYM I-LF
+macrophage NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+cell NOUN I-LF
+; PUNCT O
+NCX PROPN B-AC
+, PUNCT O
+Na+/Ca2 NOUN B-LF
++ NUM I-LF
+exchanger NOUN I-LF
+; PUNCT O
+ns NOUN B-AC
+, PUNCT O
+nonsilencing NOUN B-LF
+; PUNCT O
+siRNA NOUN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+; PUNCT O
+Slc8 NOUN O
+, PUNCT O
+solute NOUN O
+carrier NOUN O
+family NOUN O
+8 NUM O
+; PUNCT O
+VR NOUN O
+, PUNCT O
+voltage NOUN O
+ramp NOUN O
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+growth NOUN O
+factor NOUN O
+stimulation NOUN O
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+mTORC1 NOUN B-AC
+via ADP O
+the DET O
+GTPase PROPN B-AC
+Rheb PROPN O
+, PUNCT O
+whereas SCONJ O
+amino ADJ O
+acids NOUN O
+activate VERB O
+mTORC1 NOUN B-AC
+through ADP O
+the DET O
+heterodimeric ADJ O
+Rag PROPN O
+, PUNCT O
+adenosine ADJ B-LF
+diphosphate NOUN I-LF
+ribosylation NOUN I-LF
+factor-1 NOUN I-LF
+( PUNCT O
+Arf1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+Rab1 PROPN O
+GTPases PROPN B-AC
+[ X O
+8–11 NUM O
+] PUNCT O
+. PUNCT O
+
+Testicular ADJ B-LF
+germ NOUN I-LF
+cell NOUN I-LF
+tumor NOUN I-LF
+( PUNCT O
+TGCT PROPN B-AC
+) PUNCT O
+patients NOUN O
+and CCONJ O
+survivors NOUN O
+have VERB O
+excess ADJ O
+mortality NOUN O
+compared VERB O
+to ADP O
+the DET O
+general ADJ O
+male ADJ O
+population NOUN O
+, PUNCT O
+but CCONJ O
+relative ADJ B-LF
+survival NOUN I-LF
+( PUNCT O
+RS NOUN B-AC
+) PUNCT O
+has AUX O
+been AUX O
+scarcely ADV O
+studied VERB O
+. PUNCT O
+
+EGFP PROPN B-AC
+, PUNCT O
+enhanced ADJ B-LF
+green ADJ I-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+Epac PROPN O
+, PUNCT O
+exchange NOUN O
+protein NOUN O
+directly ADV O
+activated VERB O
+by ADP O
+cAMP NOUN B-AC
+; PUNCT O
+GAPDH PROPN B-AC
+, PUNCT O
+glyceraldehyde NOUN B-LF
+3 NUM I-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+; PUNCT O
+HA3 PROPN B-AC
+, PUNCT O
+triple ADJ B-LF
+hemagglutinin NOUN I-LF
+; PUNCT O
+IFA PROPN B-AC
+, PUNCT O
+immunofluorescence NOUN B-LF
+assay NOUN I-LF
+; PUNCT O
+PKAc PROPN B-AC
+, PUNCT O
+catalytic ADJ B-LF
+subunit NOUN I-LF
+of ADP I-LF
+cAMP NOUN I-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+; PUNCT O
+PMV PROPN O
+, PUNCT O
+plasmepsin NOUN O
+V NOUN O
+; PUNCT O
+RAP PROPN B-AC
+, PUNCT O
+rapamycin NOUN B-LF
+. PUNCT O
+
+* PUNCT O
+* PUNCT O
+PCa NOUN B-AC
+: PUNCT O
+Prostate NOUN B-LF
+cancer NOUN I-LF
+. PUNCT O
+
+A. X O
+The DET O
+network NOUN O
+’s PART O
+strongly ADV B-LF
+connected VERB I-LF
+component NOUN I-LF
+( PUNCT O
+SCC PROPN B-AC
+) PUNCT O
+comprises VERB O
+almost ADV O
+half NOUN O
+of ADP O
+the DET O
+nodes NOUN O
+and CCONJ O
+more ADJ O
+than ADP O
+two NUM O
+- PUNCT O
+thirds NOUN O
+of ADP O
+the DET O
+edges NOUN O
+; PUNCT O
+it PRON O
+contains VERB O
+both CCONJ O
+positive ADJ O
+and CCONJ O
+negative ADJ O
+feedback NOUN O
+loops NOUN O
+. PUNCT O
+
+The DET O
+Pan PROPN B-LF
+American PROPN I-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+PAHO PROPN B-AC
+) PUNCT O
+and CCONJ O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+published VERB O
+an DET O
+alert NOUN O
+about ADP O
+a DET O
+possible ADJ O
+association NOUN O
+with ADP O
+increases NOUN O
+in ADP O
+reports NOUN O
+of ADP O
+congenital ADJ O
+abnormalities NOUN O
+and CCONJ O
+Guillain PROPN B-LF
+– PUNCT I-LF
+Barré PROPN I-LF
+syndrome NOUN I-LF
+( PUNCT O
+GBS PROPN B-AC
+) PUNCT O
+on ADP O
+December PROPN O
+1 NUM O
+, PUNCT O
+2015 NUM O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+SOFA PROPN B-AC
+: PUNCT O
+sequential ADJ B-LF
+organ NOUN I-LF
+failure NOUN I-LF
+assessment NOUN I-LF
+, PUNCT O
+SAPS PROPN B-AC
+II NUM B-AC
+: PUNCT O
+simplified ADJ O
+acute ADJ O
+physiologic ADJ O
+score NOUN O
+, PUNCT O
+ISS PROPN B-AC
+: PUNCT O
+injury NOUN B-LF
+severity NOUN I-LF
+score NOUN I-LF
+, PUNCT O
+AIS PROPN B-AC
+: PUNCT O
+abbreviated ADJ B-LF
+injury NOUN I-LF
+scale NOUN I-LF
+, PUNCT O
+SAP PROPN B-AC
+: PUNCT O
+systolic ADJ B-LF
+arterial ADJ I-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+, PUNCT O
+ICU PROPN B-AC
+: PUNCT O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+, PUNCT O
+LOS PROPN B-AC
+: PUNCT O
+length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+. PUNCT O
+
+CNO PROPN B-AC
+, PUNCT O
+clozapine NOUN B-LF
+- PUNCT I-LF
+n CCONJ I-LF
+- PUNCT I-LF
+oxide NOUN I-LF
+; PUNCT O
+LH PROPN B-AC
+, PUNCT O
+lateral ADJ B-LF
+hypothalamic ADJ I-LF
+area NOUN I-LF
+; PUNCT O
+Nts PROPN B-AC
+, PUNCT O
+neurotensin NOUN B-LF
+. PUNCT O
+
+* PUNCT O
+HF PROPN B-AC
+= PUNCT O
+Health PROPN B-LF
+Facility PROPN I-LF
+. PUNCT O
+
+GABA NOUN B-AC
+, PUNCT O
+γ NOUN B-LF
+- PUNCT I-LF
+aminobutyric ADJ I-LF
+acid NOUN I-LF
+; PUNCT O
+gad NOUN B-AC
+, PUNCT O
+glutamate NOUN B-LF
+decarboxylase NOUN I-LF
+enzyme NOUN I-LF
+gene NOUN I-LF
+. PUNCT O
+
+Streck NOUN O
+= PUNCT O
+cfDNA NOUN B-AC
+Urine NOUN O
+Preserve PROPN O
+, PUNCT O
+UCM PROPN B-AC
+= PUNCT O
+Urine NOUN B-LF
+conservation NOUN I-LF
+medium NOUN I-LF
+. PUNCT O
+
+These DET O
+small ADJ O
+regulatory ADJ O
+RNAs NOUN O
+are AUX O
+mainly ADV O
+of ADP O
+two NUM O
+types NOUN O
+; PUNCT O
+microRNAs NOUN B-LF
+( PUNCT O
+miRNAs NOUN B-AC
+) PUNCT O
+and CCONJ O
+short ADJ B-LF
+interfering VERB I-LF
+RNAs NOUN I-LF
+( PUNCT O
+siRNAs NOUN B-AC
+) PUNCT O
+, PUNCT O
+both PRON O
+of ADP O
+which PRON O
+consist VERB O
+of ADP O
+21–24 NUM O
+nucleotide NOUN O
+and CCONJ O
+are AUX O
+generated VERB O
+from ADP O
+the DET O
+synthesis NOUN O
+processes NOUN O
+of ADP O
+double ADJ B-LF
+- PUNCT I-LF
+stranded ADJ I-LF
+RNAs NOUN I-LF
+( PUNCT O
+dsRNA NOUN B-AC
+) PUNCT O
+[ PUNCT O
+1,2 NUM O
+] PUNCT O
+. PUNCT O
+
+Local ADJ O
+values NOUN O
+of ADP O
+spatiotemporal ADJ O
+contrast NOUN O
+ranged VERB O
+from ADP O
+6 NUM O
+% NOUN O
+to ADP O
+50 NUM O
+% NOUN O
+root NOUN B-LF
+- PUNCT I-LF
+mean NOUN I-LF
+- PUNCT I-LF
+squared VERB I-LF
+( PUNCT O
+RMS PROPN B-AC
+) PUNCT O
+contrast NOUN O
+( PUNCT O
+see VERB O
+Methods NOUN O
+) PUNCT O
+. PUNCT O
+
+BC NOUN B-AC
+= PUNCT O
+breast NOUN B-LF
+cancer NOUN I-LF
+symptom NOUN O
+; PUNCT O
+GP NOUN O
+= PUNCT O
+general ADJ O
+population NOUN O
+
+NC PROPN O
+: PUNCT O
+Normal ADJ O
+control NOUN O
+; PUNCT O
+EG PROPN B-AC
+: PUNCT O
+Ethylene NOUN B-LF
+glycol NOUN I-LF
+; PUNCT O
+CYS PROPN B-AC
+: PUNCT O
+Cystone PROPN B-LF
+; PUNCT O
+STS PROPN B-AC
+: PUNCT O
+Sodium NOUN B-LF
+thiosulfate NOUN I-LF
+; PUNCT O
+CAND NOUN B-AC
+: PUNCT O
+Candesartan PROPN B-LF
+. PUNCT O
+
+LFP NOUN B-AC
+, PUNCT O
+local ADJ B-LF
+field NOUN I-LF
+potential NOUN I-LF
+; PUNCT O
+MG NOUN B-AC
+, PUNCT O
+mid ADJ B-LF
+- ADJ I-LF
+frequency ADJ I-LF
+gamma NOUN I-LF
+; PUNCT O
+SG NOUN B-AC
+, PUNCT O
+slow ADJ B-LF
+gamma NOUN I-LF
+. PUNCT O
+
+AUC PROPN B-AC
+, PUNCT O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+receiver NOUN I-LF
+operating NOUN I-LF
+characteristics NOUN I-LF
+curve NOUN I-LF
+; PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+XGBoost PROPN B-AC
+, PUNCT O
+extreme ADJ B-LF
+gradient NOUN I-LF
+boost NOUN I-LF
+. PUNCT O
+
+Corn NOUN O
+soy NOUN O
+blend NOUN O
+with ADP O
+extra ADJ O
+micronutrients NOUN O
+( PUNCT O
+CSB PROPN O
+) PUNCT O
+is AUX O
+a DET O
+widely ADV O
+- PUNCT O
+applied VERB O
+ready ADJ B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+use VERB I-LF
+supplementary ADJ I-LF
+food NOUN I-LF
+( PUNCT O
+RUSF PROPN B-AC
+) PUNCT O
+to PART O
+treat VERB O
+malnourished ADJ O
+children NOUN O
+. PUNCT O
+
+IMD PROPN B-AC
+, PUNCT O
+Index PROPN B-LF
+of ADP I-LF
+Multiple PROPN I-LF
+Deprivation PROPN I-LF
+. PUNCT O
+
+M NOUN O
+: PUNCT O
+males NOUN O
+; PUNCT O
+F NOUN O
+: PUNCT O
+females NOUN O
+; PUNCT O
+P NOUN O
+- NOUN O
+S NOUN O
+: PUNCT O
+phase NOUN O
+- NOUN O
+sensitive ADJ O
+device NOUN O
+; PUNCT O
+BIA NOUN B-AC
+: PUNCT O
+bioelectrical ADJ B-LF
+impedance NOUN I-LF
+analysis NOUN I-LF
+; PUNCT O
+BIVA NOUN B-AC
+: PUNCT O
+bioelectrical ADJ B-LF
+impedance NOUN I-LF
+vector NOUN I-LF
+analysis NOUN I-LF
+; PUNCT O
+DXA NOUN B-AC
+: PUNCT O
+dual ADJ B-LF
+- NOUN I-LF
+energy NOUN I-LF
+X NOUN I-LF
+- NOUN I-LF
+ray NOUN I-LF
+absorptiometry NOUN I-LF
+; PUNCT O
+R NOUN O
+: PUNCT O
+resistance NOUN O
+; PUNCT O
+Xc NOUN B-AC
+: PUNCT O
+reactance NOUN O
+; PUNCT O
+PA NOUN B-AC
+: PUNCT O
+phase NOUN B-LF
+angle NOUN I-LF
+; PUNCT O
+h NOUN O
+: PUNCT O
+height NOUN O
+; PUNCT O
+BM NOUN B-AC
+: PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+; PUNCT O
+RPE NOUN O
+: PUNCT O
+rating NOUN O
+of ADP O
+perceived VERB O
+exertion NOUN O
+; PUNCT O
+BMI PROPN B-AC
+: PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+
+To PART O
+obtain VERB O
+the DET O
+most ADV O
+robust ADJ O
+prediction NOUN O
+of ADP O
+QTLs NOUN B-AC
+, PUNCT O
+several ADJ O
+mapping NOUN O
+methods NOUN O
+were AUX O
+applied VERB O
+to PART O
+search VERB O
+for ADP O
+QTLs NOUN B-AC
+, PUNCT O
+including VERB O
+single ADJ O
+marker NOUN O
+analysis NOUN O
+[ PUNCT O
+36 NUM O
+] PUNCT O
+, PUNCT O
+interval NOUN B-LF
+mapping NOUN I-LF
+( PUNCT O
+IM PROPN B-AC
+) PUNCT O
+[ PUNCT O
+37 NUM O
+] PUNCT O
+, PUNCT O
+composite ADJ B-LF
+interval NOUN I-LF
+mapping NOUN I-LF
+( PUNCT O
+CIM PROPN B-AC
+) PUNCT O
+[ PUNCT O
+38,39 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+multiple ADJ B-LF
+interval NOUN I-LF
+mapping NOUN I-LF
+( PUNCT O
+MIM PROPN B-AC
+) PUNCT O
+[ PUNCT O
+40 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
+regimen NOUN O
+was AUX O
+intended VERB O
+to PART O
+mimic VERB O
+the DET O
+in ADP O
+vivo ADJ O
+behavioral ADJ O
+experiments NOUN O
+, PUNCT O
+in ADP O
+which PRON O
+spatial ADJ O
+learning NOUN O
+is AUX O
+tested VERB O
+long ADV O
+after SCONJ O
+FGL PROPN B-AC
+has AUX O
+been AUX O
+cleared VERB O
+from ADP O
+cerebrospinal ADJ B-LF
+fluid NOUN I-LF
+( PUNCT O
+CSF PROPN B-AC
+) PUNCT O
+[ PUNCT O
+13 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+began VERB O
+by ADP O
+cloning VERB O
+the DET O
+CD4 NOUN O
+genes NOUN O
+of ADP O
+15 NUM O
+primate ADJ O
+species NOUN O
+, PUNCT O
+plus CCONJ O
+human ADJ O
+CD4 NOUN O
+. PUNCT O
+Using VERB O
+retroviral ADJ O
+transduction NOUN O
+, PUNCT O
+we PRON O
+stably ADV O
+introduced VERB O
+these DET O
+genes NOUN O
+into ADP O
+Cf2Th NOUN O
+cells NOUN O
+( PUNCT O
+dog NOUN O
+thymocytes NOUN O
+) PUNCT O
+that PRON O
+had AUX O
+also ADV O
+been AUX O
+engineered VERB O
+to PART O
+express VERB O
+the DET O
+human ADJ O
+C PROPN B-LF
+- PUNCT I-LF
+C PROPN I-LF
+motif NOUN I-LF
+chemokine NOUN I-LF
+receptor NOUN I-LF
+5 NUM I-LF
+( PUNCT O
+CCR5 PROPN B-AC
+) PUNCT O
+coreceptor NOUN O
+for ADP O
+HIV-1 PROPN O
+entry NOUN O
+( PUNCT O
+S1 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+SCO PROPN B-LF
+- ADJ I-LF
+spondin ADJ I-LF
+- ADJ I-LF
+like ADJ I-LF
+
+Underlying ADJ O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+hpf PROPN B-AC
+, PUNCT O
+hours NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+; PUNCT O
+KD PROPN B-AC
+, PUNCT O
+knock NOUN B-LF
+- PUNCT I-LF
+down NOUN I-LF
+; PUNCT O
+n.s PROPN O
+. PUNCT O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+PhR PROPN B-AC
+, PUNCT O
+photoreceptor NOUN B-LF
+; PUNCT O
+WT PROPN O
+, PUNCT O
+wild ADJ O
+type NOUN O
+. PUNCT O
+
+SA NOUN B-AC
+: PUNCT O
+suture NOUN B-LF
+anchor NOUN I-LF
+, PUNCT O
+TS NOUN B-AC
+: PUNCT O
+transosseous ADJ B-LF
+suture NOUN I-LF
+, PUNCT O
+BMI NOUN B-AC
+: PUNCT O
+body NOUN O
+- PUNCT O
+mass NOUN O
+index NOUN O
+
+Proopiomelanocortin NOUN B-LF
+( PUNCT O
+POMC PROPN B-AC
+) PUNCT O
+and CCONJ O
+proenkephalin NOUN B-LF
+( PUNCT O
+PENK PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+precursors NOUN O
+of ADP O
+the DET O
+endogenous ADJ O
+peptide NOUN O
+ligands NOUN O
+endorphins NOUN O
+and CCONJ O
+enkephalins NOUN O
+, PUNCT O
+have AUX O
+been AUX O
+detected VERB O
+in ADP O
+human ADJ O
+skin NOUN O
+[ PUNCT O
+7 NUM O
+, PUNCT O
+9–15 NUM O
+] PUNCT O
+. PUNCT O
+
+† PUNCT O
+C.I. PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+HU PROPN O
+, PUNCT O
+Hounsfield PROPN O
+unit NOUN O
+; PUNCT O
+HUHA PROPN B-AC
+, PUNCT O
+Hounsfield PROPN B-LF
+unit NOUN I-LF
+histogram NOUN I-LF
+analysis NOUN I-LF
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+. PUNCT O
+
+The PRON O
+curve NOUN O
+line NOUN O
+represents VERB O
+alkali NOUN B-LF
+- PUNCT I-LF
+salt NOUN I-LF
+tolerance NOUN I-LF
+trait NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+ASTTI NOUN B-AC
+) PUNCT O
+. PUNCT O
+The PRON O
+greater ADJ O
+the DET O
+ASTTI NOUN B-AC
+, PUNCT O
+the DET O
+better ADJ O
+the DET O
+alkali NOUN O
+salt NOUN O
+tolerance NOUN O
+. PUNCT O
+
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+OR PROPN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+W NOUN O
+, PUNCT O
+weight NOUN O
+. PUNCT O
+
+Bulimia PROPN B-LF
+nervosa NOUN I-LF
+( PUNCT O
+BN PROPN B-AC
+) PUNCT O
+describes VERB O
+recurring VERB O
+episodes NOUN O
+of ADP O
+binge NOUN O
+eating NOUN O
+and CCONJ O
+inappropriate ADJ O
+compensatory ADJ O
+behaviour NOUN O
+to PART O
+prevent VERB O
+weight NOUN O
+gain NOUN O
+. PUNCT O
+
+Three NUM O
+polyproline NOUN B-LF
+II NUM I-LF
+helix NOUN O
+regions NOUN O
+— PUNCT O
+P13 NOUN O
+– SYM O
+P16 NOUN O
+( PUNCT O
+PPII-1 NOUN B-AC
+) PUNCT O
+, PUNCT O
+P19 PROPN O
+– SYM O
+P22 NOUN O
+( PUNCT O
+PPII-2 NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+P28 PROPN O
+– SYM O
+P31 NOUN O
+( PUNCT O
+PPII-3 NOUN B-AC
+) PUNCT O
+— PUNCT O
+are AUX O
+labeled VERB O
+. PUNCT O
+( PUNCT O
+C NOUN O
+– SYM O
+D NOUN O
+) PUNCT O
+Increase NOUN O
+in ADP O
+surface NOUN O
+area NOUN O
+in ADP O
+larger ADJ O
+PXX33 PROPN O
+polypeptides NOUN O
+( PUNCT O
+C NOUN O
+) PUNCT O
+versus ADP O
+PXX12 PROPN O
+polypeptides NOUN O
+( PUNCT O
+D NOUN O
+) PUNCT O
+, PUNCT O
+resulting VERB O
+in ADP O
+increased VERB O
+interaction NOUN O
+, PUNCT O
+van PROPN O
+der PROPN O
+Waals PROPN O
+attraction NOUN O
+, PUNCT O
+and CCONJ O
+denser ADJ O
+aggregates NOUN O
+. PUNCT O
+
+The DET O
+recorded VERB O
+comorbidities NOUN O
+were AUX O
+hypertension NOUN B-LF
+( PUNCT O
+HT PROPN B-AC
+) PUNCT O
+, PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+( PUNCT O
+DM PROPN B-AC
+) PUNCT O
+, PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+COPD PROPN B-AC
+) PUNCT O
+, PUNCT O
+stroke NOUN O
+, PUNCT O
+cirrhosis NOUN O
+, PUNCT O
+and CCONJ O
+end NOUN B-LF
+- PUNCT I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD PROPN B-AC
+) PUNCT O
+. PUNCT O
+Specifically ADV O
+, PUNCT O
+ESRD PROPN B-AC
+was AUX O
+defined VERB O
+as ADP O
+estimated VERB O
+GFR NOUN O
+< ADP O
+15 NUM O
+mL NOUN O
+/ SYM O
+min/1.73m2 NUM O
+with ADP O
+long ADJ O
+- PUNCT O
+term NOUN O
+dialysis NOUN O
+therapy NOUN O
+. PUNCT O
+
+topoisomerase NOUN B-LF
+I NOUN I-LF
+- PUNCT I-LF
+activated VERB I-LF
+pCR2.1 NOUN I-LF
+- PUNCT I-LF
+TOPO NOUN I-LF
+vector NOUN I-LF
+
+Primary ADJ O
+outcome NOUN O
+was AUX O
+post ADJ B-LF
+- PUNCT I-LF
+traumatic ADJ I-LF
+stress NOUN I-LF
+disorder NOUN I-LF
+( PUNCT O
+PTSD PROPN B-AC
+) PUNCT O
+symptoms NOUN O
+or CCONJ O
+caseness NOUN O
+, PUNCT O
+and CCONJ O
+secondary ADJ O
+outcomes NOUN O
+were AUX O
+depression NOUN O
+symptoms NOUN O
+, PUNCT O
+functioning NOUN O
+, PUNCT O
+quality NOUN O
+of ADP O
+life NOUN O
+, PUNCT O
+and CCONJ O
+adverse ADJ O
+effects NOUN O
+, PUNCT O
+after ADP O
+treatment NOUN O
+and CCONJ O
+at ADV O
+follow NOUN O
+- PUNCT O
+up NOUN O
+of ADP O
+at ADV O
+least ADV O
+3 NUM O
+months NOUN O
+. PUNCT O
+
+Combinations NOUN O
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+PA PROPN B-AC
+plus CCONJ O
+EF PROPN B-AC
+or CCONJ O
+LF PROPN B-AC
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+respectively ADV O
+referred VERB O
+to ADP O
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+toxin NOUN O
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+LeTx PROPN B-AC
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+[ PUNCT O
+13 NUM O
+] PUNCT O
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+
+CTX PROPN B-AC
+- PUNCT B-AC
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+- PUNCT I-LF
+terminal ADJ I-LF
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+type NOUN I-LF
+I NUM I-LF
+collagen NOUN I-LF
+; PUNCT O
+ELISA PROPN O
+, PUNCT O
+enzyme NOUN O
+linked VERB O
+immunosorbent NOUN O
+assay NOUN O
+; PUNCT O
+M PROPN B-AC
+- PUNCT B-AC
+CSF PROPN B-AC
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+macrophage NOUN B-LF
+colony NOUN I-LF
+- PUNCT I-LF
+stimulating VERB I-LF
+factor NOUN I-LF
+; PUNCT O
+OVX PROPN B-AC
+, PUNCT O
+ovariectomy NOUN B-LF
+- PUNCT O
+induced VERB O
+bone NOUN O
+loss NOUN O
+; PUNCT O
+PBS PROPN B-AC
+, PUNCT O
+phosphate NOUN B-LF
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+buffered VERB I-LF
+saline NOUN I-LF
+; PUNCT O
+RGD PROPN B-AC
+, PUNCT O
+Arginine PROPN B-LF
+- PUNCT I-LF
+Glycine PROPN I-LF
+- PUNCT I-LF
+Aspartic NOUN I-LF
+acid NOUN I-LF
+; PUNCT O
+s.c X O
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+WT PROPN B-AC
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+type NOUN I-LF
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+
+Loss NOUN O
+of ADP O
+BBS PROPN B-AC
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+entry NOUN O
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+exit NOUN O
+of ADP O
+signalling VERB O
+receptors NOUN O
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+3 NUM I-LF
+( PUNCT O
+Sstr3 NOUN B-AC
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+melanin NOUN B-LF
+- PUNCT I-LF
+concentrating VERB I-LF
+hormone NOUN I-LF
+receptor NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+Mchr1 NOUN B-AC
+) PUNCT O
+, PUNCT O
+dopamine NOUN B-LF
+receptors NOUN I-LF
+( PUNCT O
+D1 NOUN B-AC
+) PUNCT O
+, PUNCT O
+G NOUN B-LF
+- PUNCT I-LF
+protein NOUN I-LF
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+receptor NOUN I-LF
+161 NUM I-LF
+( PUNCT O
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+neurotrophic ADJ I-LF
+factor NOUN I-LF
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+] PUNCT O
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+This DET O
+study NOUN O
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+accordance NOUN O
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+REporting NOUN B-LF
+of ADP I-LF
+studies NOUN I-LF
+Conducted VERB I-LF
+using VERB I-LF
+Observational ADJ I-LF
+Routinely ADV I-LF
+collected VERB I-LF
+health NOUN I-LF
+Data NOUN I-LF
+( PUNCT O
+RECORD NOUN B-AC
+) PUNCT O
+statement NOUN O
+( PUNCT O
+see VERB O
+S1 PROPN O
+Checklist NOUN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+further ADV O
+showed VERB O
+that SCONJ O
+the DET O
+eye NOUN B-LF
+- PUNCT I-LF
+enriched VERB I-LF
+kainate NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+EKAR PROPN B-AC
+) PUNCT O
+receives VERB O
+the DET O
+retrograde ADJ O
+glutamate NOUN O
+signal NOUN O
+in ADP O
+photoreceptor NOUN O
+terminals NOUN O
+. PUNCT O
+
+We PRON O
+then ADV O
+verified VERB O
+each DET O
+candidate NOUN O
+by ADP O
+using VERB O
+Integrative PROPN B-LF
+Genomics PROPN I-LF
+Viewer PROPN I-LF
+( PUNCT O
+IGV PROPN B-AC
+, PUNCT O
+[ X O
+38–40 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Cotrimoxazole NOUN B-LF
+( PUNCT O
+CTX PROPN B-AC
+) PUNCT O
+prophylaxis NOUN O
+is AUX O
+recommended VERB O
+by ADP O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+for ADP O
+HIV-1 NUM B-AC
+- PUNCT O
+infected VERB O
+individuals NOUN O
+in ADP O
+settings NOUN O
+with ADP O
+high ADJ O
+infectious ADJ O
+disease NOUN O
+prevalence NOUN O
+. PUNCT O
+
+Scaffold NOUN B-LF
+/ SYM I-LF
+matrix NOUN I-LF
+attachment NOUN I-LF
+regions NOUN I-LF
+( PUNCT O
+S PROPN B-AC
+/ SYM B-AC
+MARs PROPN O
+) PUNCT O
+are AUX O
+AT NOUN O
+- PUNCT O
+rich ADJ O
+DNA NOUN O
+sequences NOUN O
+that PRON O
+mediate VERB O
+structural ADJ O
+organization NOUN O
+of ADP O
+the DET O
+chromatin NOUN O
+within ADP O
+the DET O
+nucleus NOUN O
+. PUNCT O
+
+To PART O
+further ADV O
+characterize VERB O
+the DET O
+interaction NOUN O
+of ADP O
+PAL PROPN B-AC
+- PUNCT O
+CRID3 PROPN O
+with ADP O
+components NOUN O
+of ADP O
+the DET O
+NLRP3 PROPN B-AC
+inflammasome NOUN O
+, PUNCT O
+we PRON O
+assessed VERB O
+binding VERB O
+to ADP O
+human ADJ O
+never ADV B-LF
+- PUNCT I-LF
+in ADP I-LF
+- PUNCT I-LF
+mitosis NOUN I-LF
+- PUNCT I-LF
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+- PUNCT I-LF
+a NOUN I-LF
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+related VERB I-LF
+kinase NOUN I-LF
+7 NUM I-LF
+( PUNCT O
+NEK7 PROPN B-AC
+) PUNCT O
+, PUNCT O
+apoptosis NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+speck NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+ASC PROPN B-AC
+) PUNCT O
+, PUNCT O
+Casp1 PROPN B-AC
+, PUNCT O
+and CCONJ O
+GSDMD PROPN B-AC
+. PUNCT O
+PAL PROPN B-AC
+- PUNCT O
+CRID3 PROPN O
+failed VERB O
+to ADP O
+label VERB O
+the DET O
+NLRP3 PROPN B-AC
+inflammasome NOUN O
+components NOUN O
+in ADP O
+the DET O
+panel NOUN O
+apart ADV O
+from ADP O
+NLRP3 PROPN B-AC
+( PUNCT O
+Fig PROPN O
+1F NUM O
+) PUNCT O
+. PUNCT O
+Collectively ADV O
+, PUNCT O
+these DET O
+results NOUN O
+suggest VERB O
+that SCONJ O
+CRID PROPN B-AC
+compounds NOUN O
+, PUNCT O
+including VERB O
+MCC950 PROPN O
+/ SYM O
+CRID3 PROPN O
+, PUNCT O
+inhibit VERB O
+NLRP3 PROPN B-AC
+inflammasome NOUN O
+signaling NOUN O
+by ADP O
+directly ADV O
+binding VERB O
+to ADP O
+NLRP3 PROPN B-AC
+. PUNCT O
+
+We PRON O
+examined VERB O
+circulating VERB O
+plasma NOUN O
+LECT2 NOUN B-AC
+levels NOUN O
+in ADP O
+the DET O
+subjects NOUN O
+with ADP O
+non ADJ B-LF
+- ADJ I-LF
+alcoholic ADJ I-LF
+fatty ADJ I-LF
+liver NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+NAFLD PROPN B-AC
+) PUNCT O
+or CCONJ O
+metabolic ADJ O
+syndrome NOUN O
+. PUNCT O
+
+The DET O
+new ADJ O
+model NOUN O
+expands VERB O
+the DET O
+currently ADV O
+prevailing ADJ O
+diffusion NOUN O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+MRI PROPN B-AC
+) PUNCT O
+tractography NOUN O
+approach NOUN O
+by ADP O
+incorporation NOUN O
+of ADP O
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+features NOUN O
+of ADP O
+cortical ADJ O
+microstructure NOUN O
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+cortico ADJ O
+– ADJ O
+cortical ADJ O
+proximity NOUN O
+. PUNCT O
+
+BPS PROPN B-AC
+, PUNCT O
+biosurfactant ADJ B-LF
+polysaccharide NOUN I-LF
+; PUNCT O
+BYK PROPN B-AC
+, PUNCT O
+bacterial ADJ B-LF
+tyrosine NOUN I-LF
+autokinase NOUN I-LF
+; PUNCT O
+EPS PROPN B-AC
+, PUNCT O
+exopolysaccharide NOUN B-LF
+; PUNCT O
+IM PROPN B-AC
+, PUNCT O
+inner ADJ B-LF
+membrane NOUN I-LF
+; PUNCT O
+MASC PROPN B-AC
+, PUNCT O
+major ADJ B-LF
+spore NOUN I-LF
+coat NOUN I-LF
+; PUNCT O
+OM PROPN B-AC
+, PUNCT O
+outer ADJ B-LF
+membrane NOUN I-LF
+. PUNCT O
+
+Thematic ADJ O
+analysis NOUN O
+was AUX O
+applied VERB O
+, PUNCT O
+and CCONJ O
+key ADJ O
+themes NOUN O
+were AUX O
+developed VERB O
+based VERB O
+on ADP O
+Kolb PROPN O
+’s PART O
+ELT PROPN B-AC
+( PUNCT O
+Experiential ADJ B-LF
+learning NOUN I-LF
+theory NOUN I-LF
+) PUNCT O
+. PUNCT O
+
+GGOH PROPN B-AC
+, PUNCT O
+geranylgeraniol NOUN B-LF
+; PUNCT O
+IDC PROPN B-AC
+, PUNCT O
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+developmental ADJ I-LF
+cycle NOUN I-LF
+; PUNCT O
+IPP PROPN B-AC
+, PUNCT O
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+pyrophosphate NOUN I-LF
+; PUNCT O
+ns NOUN O
+, PUNCT O
+not PART O
+significant ADJ O
+. PUNCT O
+
+Parameter NOUN B-LF
+profile NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+IPP PROPN B-AC
+) PUNCT O
+
+Rumah PROPN B-LF
+- PUNCT I-LF
+Sakit PROPN I-LF
+- PUNCT I-LF
+Umum PROPN I-LF
+- PUNCT I-LF
+Daerah PROPN I-LF
+( PUNCT O
+RSUD PROPN B-AC
+) PUNCT O
+is AUX O
+the DET O
+major ADJ O
+regional ADJ O
+hospital NOUN O
+in ADP O
+the DET O
+Mimika PROPN O
+District PROPN O
+of ADP O
+Papua PROPN O
+, PUNCT O
+Indonesia PROPN O
+. PUNCT O
+
+The DET O
+classical ADJ O
+parameters NOUN O
+of ADP O
+HRV NOUN B-AC
+, PUNCT O
+the DET O
+frequency NOUN O
+parameters NOUN O
+of ADP O
+the DET O
+Low PROPN B-LF
+Frequency PROPN I-LF
+( PUNCT O
+LF PROPN B-AC
+) PUNCT O
+and CCONJ O
+High PROPN B-LF
+Frequency PROPN I-LF
+( PUNCT O
+HF PROPN B-AC
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+, PUNCT O
+and CCONJ O
+their PRON O
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+values NOUN O
+, PUNCT O
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+as ADV O
+well ADV O
+. PUNCT O
+
+We PRON O
+made VERB O
+use NOUN O
+of ADP O
+the DET O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+( PUNCT O
+GFP PROPN B-AC
+) PUNCT O
+transgenic ADJ O
+line NOUN O
+her5pac NOUN O
+: NOUN O
+egfp PROPN O
+[ X O
+24 NUM O
+] PUNCT O
+, PUNCT O
+which PRON O
+shows VERB O
+a DET O
+very ADV O
+robust ADJ O
+GFP PROPN B-AC
+expression NOUN O
+in ADP O
+a DET O
+V NOUN O
+- ADJ O
+shaped ADJ O
+territory NOUN O
+covering VERB O
+the DET O
+anlagen NOUN O
+of ADP O
+the DET O
+midbrain NOUN O
+and CCONJ O
+rostral ADJ O
+hindbrain NOUN O
+at ADP O
+bud NOUN O
+stage NOUN O
+. PUNCT O
+
+In ADP O
+Vancouver PROPN O
+study NOUN O
+center NOUN O
+, PUNCT O
+8 NUM O
+% NOUN O
+of ADP O
+the DET O
+subjects NOUN O
+presented VERB O
+with ADP O
+hyperhidrosis NOUN B-LF
+as SCONJ O
+the DET O
+primary ADJ O
+concern NOUN O
+, PUNCT O
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+compared VERB O
+with ADP O
+no DET O
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+patients NOUN O
+in ADP O
+the DET O
+Shanghai PROPN O
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+( PUNCT O
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+1 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+2.5E-20 NUM O
+) PUNCT O
+, PUNCT O
+indicating VERB O
+there PRON O
+is VERB O
+a DET O
+low ADJ O
+level NOUN O
+of ADP O
+awareness NOUN O
+of ADP O
+HH PROPN B-AC
+in ADP O
+Shanghai PROPN O
+. PUNCT O
+
+HMD NOUN B-AC
+- PUNCT O
+Hyaline NOUN B-LF
+membrane NOUN I-LF
+disease NOUN I-LF
+, PUNCT O
+ANC NOUN B-AC
+- PUNCT O
+Antenatal ADJ B-LF
+care NOUN I-LF
+, PUNCT O
+APH NOUN B-AC
+- PUNCT O
+Antepartum NOUN B-LF
+Hemorrhage NOUN I-LF
+, PUNCT O
+COR NOUN O
+- PUNCT O
+Crude NOUN O
+odd ADJ O
+ratio NOUN O
+, PUNCT O
+AOR NOUN B-AC
+- PUNCT O
+Adjusted VERB B-LF
+Odd ADJ I-LF
+Ratio NOUN I-LF
+
+N2RA NOUN B-AC
+/ SYM O
+RA NOUN O
+; PUNCT O
+N1+/RA NOUN B-AC
+, PUNCT O
+Notch1 PROPN B-LF
+/ SYM O
+Notch2 NOUN O
+RA NOUN O
+homozygous ADJ O
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+Arg PROPN O
+( PUNCT O
+N1R1974 NOUN O
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+N2R1934 PROPN O
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+Ala PROPN O
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+; PUNCT O
+SMZL PROPN B-AC
+, PUNCT O
+splenic ADJ B-LF
+marginal ADJ I-LF
+zone NOUN I-LF
+B PROPN I-LF
+- PUNCT I-LF
+cell NOUN I-LF
+lymphoma NOUN I-LF
+. PUNCT O
+
+Sequence NOUN O
+analysis NOUN O
+of ADP O
+random ADJ O
+sheared VERB O
+fragments NOUN O
+[ PUNCT O
+20 NUM O
+] PUNCT O
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+( PUNCT O
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+artificial ADJ I-LF
+chromosome NOUN I-LF
+) PUNCT O
+end NOUN O
+sequences NOUN O
+( PUNCT O
+BESs PROPN B-AC
+) PUNCT O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+complete ADJ O
+BAC PROPN B-AC
+sequences NOUN O
+from ADP O
+100 NUM O
+random ADJ O
+regions NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+showed VERB O
+that SCONJ O
+about ADV O
+two NUM O
+- PUNCT O
+thirds NOUN O
+of ADP O
+the DET O
+maize NOUN O
+genome NOUN O
+consists VERB O
+of ADP O
+transposable ADJ O
+elements NOUN O
+, PUNCT O
+with ADP O
+95 NUM O
+% NOUN O
+of ADP O
+those PRON O
+being AUX O
+retrotransposons NOUN O
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+
+The DET O
+first ADJ B-LF
+dry ADJ I-LF
+season NOUN I-LF
+D1 PROPN B-AC
+( PUNCT O
+May PROPN O
+2013 NUM O
+– SYM O
+October PROPN O
+2013 NUM O
+) PUNCT O
+began VERB O
+immediately ADV O
+after ADP O
+the DET O
+releases NOUN O
+, PUNCT O
+followed VERB O
+by ADP O
+the DET O
+first ADJ B-LF
+wet ADJ I-LF
+season NOUN I-LF
+W1 PROPN B-AC
+( PUNCT O
+November PROPN O
+2013 NUM O
+– SYM O
+April PROPN O
+2014 NUM O
+) PUNCT O
+, PUNCT O
+the DET O
+second ADJ B-LF
+dry ADJ I-LF
+season NOUN I-LF
+D2 PROPN B-AC
+( PUNCT O
+May PROPN O
+2014 NUM O
+– SYM O
+Oct PROPN O
+2014 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+second ADJ B-LF
+wet ADJ I-LF
+season NOUN I-LF
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+( PUNCT O
+Nov PROPN O
+2014 NUM O
+– SYM O
+Apr PROPN O
+2015 NUM O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+human ADJ O
+functional ADJ B-LF
+magnetic ADJ I-LF
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+imaging NOUN I-LF
+( PUNCT O
+fMRI NOUN B-AC
+) PUNCT O
+studies NOUN O
+have AUX O
+also ADV O
+examined VERB O
+whether SCONJ O
+activity NOUN O
+throughout ADP O
+the DET O
+brain NOUN O
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+reward NOUN O
+PEs NOUN B-AC
+[ PUNCT O
+8–14 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
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+a DET O
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+- PUNCT O
+blind ADJ O
+randomised ADJ O
+controlled ADJ O
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+small ADJ B-LF
+- PUNCT I-LF
+quantity NOUN I-LF
+lipid NOUN I-LF
+- PUNCT I-LF
+based VERB I-LF
+nutrient NOUN I-LF
+supplements NOUN I-LF
+( PUNCT O
+SQ PROPN B-AC
+- PUNCT B-AC
+LNS PROPN B-AC
+) PUNCT O
+fortified VERB O
+with ADP O
+23 NUM O
+micronutrients NOUN O
+in ADP O
+children NOUN O
+aged ADJ O
+6 NUM O
+months NOUN B-LF
+( PUNCT O
+mo NOUN B-AC
+) PUNCT O
+to PART O
+5 NUM O
+years NOUN O
+( PUNCT O
+y NOUN O
+) PUNCT O
+presenting VERB O
+with ADP O
+an DET O
+illness NOUN O
+at ADP O
+a DET O
+rural ADJ O
+primary ADJ O
+healthcare NOUN O
+centre NOUN O
+in ADP O
+The DET O
+Gambia PROPN O
+. PUNCT O
+
+CHO PROPN B-AC
+, PUNCT O
+Chinese ADJ O
+Hamster NOUN O
+Ovary PROPN O
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
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+. PUNCT O
+
+Screening NOUN O
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+reviewers NOUN O
+( PUNCT O
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+) PUNCT O
+, PUNCT O
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+online ADJ O
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+software NOUN O
+( PUNCT O
+Distiller PROPN B-LF
+Systematic PROPN I-LF
+Review PROPN I-LF
+( PUNCT O
+DSR PROPN B-AC
+) PUNCT O
+Software PROPN O
+; PUNCT O
+Evidence PROPN O
+Partners PROPN O
+Inc PROPN O
+, PUNCT O
+Ottawa PROPN O
+, PUNCT O
+Canada PROPN O
+) PUNCT O
+. PUNCT O
+
+An DET O
+ontology NOUN O
+helps VERB O
+to PART O
+clarify VERB O
+a DET O
+domain NOUN O
+'s PART O
+semantics NOUN O
+for ADP O
+everyday ADJ O
+use NOUN O
+, PUNCT O
+as SCONJ O
+is AUX O
+nicely ADV O
+demonstrated VERB O
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+Ontology PROPN I-LF
+( PUNCT O
+GO PROPN B-AC
+; PUNCT O
+The DET O
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+Ontology PROPN I-LF
+Consortium PROPN O
+2000 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+carbohydrate NOUN O
+composition NOUN O
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+extracts NOUN O
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+using VERB O
+polysaccharide NOUN B-LF
+analysis NOUN I-LF
+by ADP I-LF
+carbohydrate NOUN I-LF
+gel NOUN I-LF
+electrophoresis NOUN I-LF
+( PUNCT O
+PACE PROPN B-AC
+) PUNCT O
+and CCONJ O
+high ADJ O
+- NOUN O
+performance NOUN O
+anion NOUN O
+- NOUN O
+exchange NOUN O
+chromatography NOUN O
+( PUNCT O
+HPAEC PROPN O
+) PUNCT O
+. PUNCT O
+Whether SCONJ O
+there PRON O
+were VERB O
+any DET O
+proteinaceous ADJ O
+moieties NOUN O
+linked VERB O
+to ADP O
+β NOUN O
+- NOUN O
+glucan NOUN O
+was AUX O
+also ADV O
+examined VERB O
+. PUNCT O
+
+MC4R PROPN B-AC
+, PUNCT O
+melanocortin NOUN B-LF
+4 NUM I-LF
+receptor NOUN I-LF
+gene NOUN O
+; PUNCT O
+PRSBMI PROPN B-AC
+, PUNCT O
+polygenic ADJ B-LF
+risk NOUN I-LF
+score NOUN I-LF
+for ADP I-LF
+BMI PROPN I-LF
+. PUNCT O
+
+OR CCONJ B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+In ADP O
+both CCONJ O
+SEEG PROPN B-AC
+( PUNCT O
+Fig PROPN O
+4A NUM O
+and CCONJ O
+4B NOUN O
+) PUNCT O
+and CCONJ O
+MEG PROPN B-AC
+( PUNCT O
+Fig PROPN O
+4C NUM O
+and CCONJ O
+4D NUM O
+) PUNCT O
+, PUNCT O
+the DET O
+connection NOUN O
+density NOUN O
+spectra NOUN O
+revealed VERB O
+an DET O
+LF NOUN B-AC
+α NOUN O
+peak NOUN O
+at ADP O
+ratios NOUN O
+1:2 NUM O
+and CCONJ O
+1:3 NUM O
+, PUNCT O
+which PRON O
+indicates VERB O
+significant ADJ O
+CFS PROPN B-AC
+coupling NOUN O
+between ADP O
+α NOUN O
+with ADP O
+β NOUN O
+and CCONJ O
+γ NOUN O
+oscillations NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+α NOUN O
+: NOUN O
+β NOUN O
+and CCONJ O
+α NOUN O
+: NOUN O
+γ NOUN O
+CFS PROPN B-AC
+. PUNCT O
+In ADP O
+SEEG PROPN B-AC
+, PUNCT O
+the DET O
+frequency NOUN O
+range NOUN O
+of ADP O
+this DET O
+peak NOUN O
+was AUX O
+approximately ADV O
+6–12 NUM O
+Hz NOUN O
+and CCONJ O
+in ADP O
+MEG PROPN B-AC
+, PUNCT O
+7–15 NUM O
+Hz NOUN O
+. PUNCT O
+This DET O
+elevated ADJ O
+amount NOUN O
+of ADP O
+significant ADJ O
+interareal ADJ O
+α NOUN O
+: NOUN O
+β NOUN O
+and CCONJ O
+α NOUN O
+: NOUN O
+γ NOUN O
+CFS PROPN B-AC
+was AUX O
+also ADV O
+reflected VERB O
+as ADP O
+a DET O
+peak NOUN O
+in ADP O
+the DET O
+corresponding ADJ O
+graph NOUN B-LF
+strength NOUN I-LF
+( PUNCT O
+GS PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+shows VERB O
+that SCONJ O
+these DET O
+CFS PROPN B-AC
+connections NOUN O
+were AUX O
+also ADV O
+stronger ADJ O
+in ADP O
+terms NOUN O
+of ADP O
+the DET O
+phase NOUN O
+- PUNCT O
+locking NOUN O
+strength NOUN O
+( PUNCT O
+S3 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+our PRON O
+present ADJ O
+study NOUN O
+, PUNCT O
+we PRON O
+hypothesize VERB O
+that SCONJ O
+the DET O
+protective ADJ O
+role NOUN O
+of ADP O
+melatonin NOUN O
+in ADP O
+decreasing VERB O
+M1 NOUN O
+phenotype NOUN O
+switching NOUN O
+depends VERB O
+on ADP O
+uncoupling VERB B-LF
+protein NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+UCP2 PROPN B-AC
+) PUNCT O
+pathway NOUN O
+in ADP O
+prorenin NOUN O
+- PUNCT O
+treated VERB O
+microglia NOUN O
+. PUNCT O
+
+Persons NOUN O
+with ADP O
+both PRON O
+CA- NOUN B-AC
+and CCONJ O
+HA PROPN B-AC
+- PUNCT O
+MRSA PROPN B-AC
+in ADP O
+repeated VERB O
+samplings NOUN O
+were AUX O
+classified VERB O
+as ADP O
+having VERB O
+a DET O
+mixed VERB O
+infection NOUN O
+and CCONJ O
+excluded VERB O
+from ADP O
+analyses NOUN O
+of ADP O
+CA- NOUN B-AC
+and CCONJ O
+HA PROPN B-AC
+- PUNCT O
+MRSA PROPN B-AC
+but CCONJ O
+included VERB O
+in ADP O
+the DET O
+analysis NOUN O
+of ADP O
+all DET O
+MRSA PROPN B-AC
+. PUNCT O
+Boundary ADJ O
+data NOUN O
+for ADP O
+mapping VERB O
+2011 NUM O
+small ADJ O
+geographies NOUN O
+( PUNCT O
+named VERB O
+Lower PROPN B-LF
+Layer PROPN I-LF
+Super PROPN I-LF
+Output PROPN I-LF
+Areas PROPN I-LF
+[ PUNCT O
+LSOAs PROPN B-AC
+] PUNCT O
+) PUNCT O
+in ADP O
+catchment NOUN O
+areas NOUN O
+were AUX O
+obtained VERB O
+from ADP O
+the DET O
+Office PROPN O
+for ADP O
+National PROPN O
+Statistics PROPN O
+, PUNCT O
+UK PROPN B-AC
+[ PUNCT O
+34 NUM O
+] PUNCT O
+. PUNCT O
+
+As ADP O
+a DET O
+positive ADJ O
+control NOUN O
+, PUNCT O
+we PRON O
+examined VERB O
+SMO PROPN O
+colocalization NOUN O
+with ADP O
+nanobody NOUN B-LF
+( PUNCT O
+Nb NOUN B-AC
+) PUNCT O
+NbSmo2 NOUN O
+, PUNCT O
+which PRON O
+binds VERB O
+efficiently ADV O
+and CCONJ O
+specifically ADV O
+to ADP O
+the DET O
+activated VERB O
+conformation NOUN O
+of ADP O
+SMO PROPN O
+( PUNCT O
+Figs NOUN O
+2A NOUN O
+and CCONJ O
+S2B PROPN O
+and CCONJ O
+S2C NOUN O
+) PUNCT O
+via ADP O
+an DET O
+intracellular ADJ O
+epitope NOUN O
+within ADP O
+the DET O
+seven NUM B-LF
+- PUNCT I-LF
+transmembrane NOUN I-LF
+( PUNCT O
+7TM NOUN B-AC
+) PUNCT O
+domain NOUN O
+( PUNCT O
+S2C NOUN O
+– SYM O
+S2E NOUN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+CTNNB1 PROPN O
+, PUNCT O
+catenin NOUN O
+beta-1 NOUN O
+; PUNCT O
+HCC PROPN B-AC
+, PUNCT O
+hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+; PUNCT O
+IHC PROPN B-AC
+, PUNCT O
+immunoblotting NOUN O
+analyses NOUN O
+; PUNCT O
+MT PROPN B-AC
+, PUNCT O
+mutant NOUN B-LF
+; PUNCT O
+PGM1 PROPN B-AC
+, PUNCT O
+phosphoglucomutase NOUN B-LF
+1 NUM I-LF
+; PUNCT O
+TP53 PROPN O
+, PUNCT O
+Cellular ADJ O
+tumor NOUN O
+antigen NOUN O
+p53 NOUN O
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Other ADJ O
+variables NOUN O
+were AUX O
+recorded VERB O
+, PUNCT O
+or CCONJ O
+automatically ADV O
+calculated VERB O
+, PUNCT O
+at ADP O
+60 NUM O
+- PUNCT O
+sec NOUN O
+intervals NOUN O
+( PUNCT O
+heart NOUN O
+rate NOUN O
+, PUNCT O
+ETCO2 NOUN B-AC
+, PUNCT O
+central ADJ B-LF
+venous ADJ I-LF
+pressure NOUN I-LF
+[ PUNCT O
+CVP NOUN B-AC
+] PUNCT O
+, PUNCT O
+systemic ADJ B-LF
+vascular ADJ I-LF
+resistance NOUN I-LF
+[ PUNCT O
+SVR PROPN B-AC
+] PUNCT O
+, PUNCT O
+CO NOUN B-AC
+, PUNCT O
+stroke NOUN B-LF
+volume NOUN I-LF
+[ PUNCT O
+SV NOUN B-AC
+] PUNCT O
+, PUNCT O
+and CCONJ O
+core NOUN O
+temperature NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+AGT NOUN B-AC
+– SYM O
+Pex5p NOUN O
+structure NOUN O
+is AUX O
+the DET O
+second ADJ O
+cargo NOUN O
+protein NOUN O
+– SYM O
+Pex5p NOUN O
+receptor NOUN O
+complex NOUN O
+determined VERB O
+to ADP O
+date NOUN O
+, PUNCT O
+the DET O
+first ADJ O
+being AUX O
+sterol NOUN B-LF
+carrier NOUN I-LF
+protein NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+SCP2)–Pex5p NOUN B-AC
+[ PUNCT O
+15 NUM O
+] PUNCT O
+. PUNCT O
+
+Members NOUN O
+( PUNCT O
+female ADJ O
+and CCONJ O
+male NOUN O
+heads NOUN O
+, PUNCT O
+and CCONJ O
+other ADJ O
+married VERB O
+male NOUN O
+and CCONJ O
+female ADJ O
+in ADP O
+the DET O
+household NOUN O
+) PUNCT O
+from ADP O
+all DET O
+the DET O
+three NUM O
+categories NOUN O
+of ADP O
+households NOUN O
+were AUX O
+selected VERB O
+purposefully ADV O
+based VERB O
+on ADP O
+their PRON O
+availability NOUN O
+and CCONJ O
+willingness NOUN O
+to PART O
+participate VERB O
+in ADP O
+individual ADJ O
+in- PUNCT O
+depth NOUN O
+interviews NOUN O
+( PUNCT O
+IDIs NOUN B-AC
+) PUNCT O
+and CCONJ O
+focus NOUN B-LF
+group NOUN I-LF
+discussions NOUN I-LF
+( PUNCT O
+FGDs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Because SCONJ O
+the DET O
+capacity NOUN O
+to PART O
+amplify VERB O
+viral ADJ B-LF
+RNA NOUN I-LF
+( PUNCT O
+vRNA NOUN B-AC
+) PUNCT O
+by ADP O
+RT NOUN O
+- PUNCT O
+PCR NOUN O
+from ADP O
+the DET O
+feces NOUN O
+of ADP O
+captive ADJ O
+primates NOUN O
+correlates VERB O
+with ADP O
+the DET O
+amount NOUN O
+of ADP O
+virus NOUN O
+in ADP O
+plasma NOUN O
+[ PUNCT O
+61 NUM O
+] PUNCT O
+, PUNCT O
+we PRON O
+used VERB O
+this PRON O
+as ADP O
+a DET O
+proxy NOUN O
+measure NOUN O
+for ADP O
+the DET O
+systemic ADJ O
+VL NOUN B-AC
+of ADP O
+wild ADJ O
+chimpanzees NOUN O
+( PUNCT O
+see VERB O
+Materials NOUN O
+and CCONJ O
+Methods NOUN O
+for ADP O
+more ADJ O
+detail NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+United PROPN B-LF
+Nations PROPN I-LF
+Children PROPN I-LF
+'s PART I-LF
+Fund PROPN I-LF
+( PUNCT O
+UNICEF PROPN B-AC
+) PUNCT O
+have AUX O
+developed VERB O
+a DET O
+comprehensive ADJ O
+strategy NOUN O
+for ADP O
+sustainable ADJ O
+measles NOUN O
+mortality NOUN O
+reduction NOUN O
+, PUNCT O
+with ADP O
+the DET O
+goal NOUN O
+of ADP O
+a DET O
+90 NUM O
+% NOUN O
+reduction NOUN O
+in ADP O
+global ADJ O
+measles NOUN O
+deaths NOUN O
+( PUNCT O
+compared VERB O
+with ADP O
+2000 NUM O
+levels NOUN O
+) PUNCT O
+by ADP O
+2010 NUM O
+. PUNCT O
+
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+as ADP O
+per ADP O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+guidelines NOUN O
+( PUNCT O
+S1 PROPN O
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+predictive ADJ O
+ability NOUN O
+of ADP O
+the DET O
+model NOUN O
+was AUX O
+assessed VERB O
+by ADP O
+determining VERB O
+the DET O
+discrimination NOUN O
+, PUNCT O
+using VERB O
+the DET O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+of ADP I-LF
+receiver NOUN I-LF
+operator NOUN I-LF
+characteristics NOUN I-LF
+( PUNCT O
+AUROC PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+its PRON O
+calibration NOUN O
+. PUNCT O
+
+The DET O
+quality NOUN O
+terms NOUN O
+come VERB O
+from ADP O
+the DET O
+Phenotype PROPN B-LF
+and CCONJ I-LF
+Trait PROPN I-LF
+Ontology PROPN I-LF
+( PUNCT O
+PATO PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+designed VERB O
+to PART O
+be AUX O
+used VERB O
+in ADP O
+combination NOUN O
+with ADP O
+species ADJ O
+- ADJ O
+specific ADJ O
+anatomical ADJ O
+ontologies NOUN O
+or CCONJ O
+other ADJ O
+cross ADJ O
+- ADJ O
+species ADJ O
+entity NOUN O
+ontologies NOUN O
+( PUNCT O
+see VERB O
+, PUNCT O
+for ADP O
+example NOUN O
+, PUNCT O
+[ X O
+11]–[13 X O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Sections NOUN O
+( PUNCT O
+5 NUM O
+μm NOUN O
+) PUNCT O
+were AUX O
+stained VERB O
+with ADP O
+hematoxylin NOUN B-LF
+– PUNCT I-LF
+eosin NOUN I-LF
+( PUNCT O
+HE PROPN B-AC
+) PUNCT O
+. PUNCT O
+For ADP O
+whole ADJ O
+- PUNCT O
+mount NOUN O
+analysis NOUN O
+, PUNCT O
+mammary ADJ O
+glands NOUN O
+were AUX O
+harvested VERB O
+and CCONJ O
+fixed VERB O
+in ADP O
+Carnoy PROPN O
+’s PART O
+solution NOUN O
+( PUNCT O
+6:3:1 NUM O
+of ADP O
+100 NUM O
+% NOUN O
+ethanol NOUN O
+, PUNCT O
+chloroform NOUN O
+, PUNCT O
+and CCONJ O
+glacial ADJ O
+acetic ADJ O
+acid NOUN O
+) PUNCT O
+and CCONJ O
+stained VERB O
+with ADP O
+Carmine PROPN O
+alum NOUN O
+. PUNCT O
+
+Immunohistochemistry NOUN B-LF
+( PUNCT O
+IHC NOUN B-AC
+) PUNCT O
+detected VERB O
+MET PROPN B-AC
+expression NOUN O
+in ADP O
+the DET O
+ducts NOUN O
+of ADP O
+METfl NOUN O
+/ SYM O
+fl NOUN O
+and CCONJ O
+MET-/- NOUN B-AC
+mice NOUN O
+. PUNCT O
+
+In ADP O
+GP PROPN O
+visits NOUN O
+for SCONJ O
+the DET O
+one NUM O
+- PUNCT O
+off NOUN O
+Healthy PROPN B-LF
+Kids PROPN I-LF
+Check PROPN I-LF
+( PUNCT O
+HKC PROPN B-AC
+) PUNCT O
+prior ADV O
+to PART O
+school NOUN O
+entry NOUN O
+( PUNCT O
+that PRON O
+stopped VERB O
+being AUX O
+reimbursed VERB O
+in ADP O
+November PROPN O
+2015 NUM O
+, PUNCT O
+and CCONJ O
+was AUX O
+rescinded VERB O
+in ADP O
+July PROPN O
+2016 NUM O
+) PUNCT O
+, PUNCT O
+there PRON O
+were VERB O
+several ADJ O
+opportunities NOUN O
+for SCONJ O
+the DET O
+family NOUN O
+to PART O
+discuss VERB O
+WCC PROPN B-AC
+activities NOUN O
+. PUNCT O
+
+Patients NOUN O
+were AUX O
+recruited VERB O
+by ADP O
+their PRON O
+treating VERB O
+clinicians NOUN O
+to ADP O
+CASCADE PROPN B-AC
+, PUNCT O
+a DET O
+prospective ADJ B-LF
+community NOUN I-LF
+- PUNCT I-LF
+based VERB I-LF
+rapid ADJ I-LF
+autopsy NOUN I-LF
+program NOUN I-LF
+[ X O
+9 NUM O
+] X O
+conducted VERB O
+in ADP O
+association NOUN O
+with ADP O
+the DET O
+Kathleen PROPN B-LF
+Cuningham PROPN I-LF
+Foundation PROPN I-LF
+Consortium PROPN I-LF
+for ADP I-LF
+Research PROPN I-LF
+into ADP I-LF
+Familial PROPN I-LF
+Breast PROPN I-LF
+Cancer PROPN I-LF
+( PUNCT O
+kConFab PROPN B-AC
+) PUNCT O
+and CCONJ O
+approved VERB O
+by ADP O
+the DET O
+Human PROPN O
+Research PROPN O
+Ethics PROPN O
+Committee PROPN O
+of ADP O
+the DET O
+Peter PROPN O
+MacCallum PROPN O
+Cancer PROPN O
+Centre PROPN O
+, PUNCT O
+Melbourne PROPN O
+( PUNCT O
+HREC PROPN O
+approval NOUN O
+numbers NOUN O
+: PUNCT O
+CASCADE PROPN B-AC
+13/122 NUM O
+, PUNCT O
+kConFab PROPN B-AC
+92/97 NUM O
+and CCONJ O
+11/102 NUM O
+) PUNCT O
+. PUNCT O
+
+Of ADP O
+this DET O
+number NOUN O
+, PUNCT O
+nearly ADV O
+82 NUM O
+% NOUN O
+had VERB O
+Multidrug NOUN O
+resistance NOUN O
+- PUNCT O
+TB PROPN B-AC
+( PUNCT O
+MDR PROPN O
+- PUNCT O
+TB PROPN B-AC
+) PUNCT O
+caused VERB O
+by ADP O
+MTBC PROPN B-AC
+resistant ADJ O
+to ADP O
+both CCONJ O
+rifampicin NOUN B-LF
+( PUNCT O
+RIF PROPN B-AC
+) PUNCT O
+and CCONJ O
+isoniazid NOUN B-LF
+( PUNCT O
+INH PROPN B-AC
+) PUNCT O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Data NOUN O
+were AUX O
+extracted VERB O
+through ADP O
+a DET O
+standardized ADJ O
+form NOUN O
+, PUNCT O
+which PRON O
+was AUX O
+in ADP O
+accordance NOUN O
+with ADP O
+the DET O
+Preferred PROPN B-LF
+Reporting PROPN I-LF
+Items PROPN I-LF
+for ADP I-LF
+Systematic PROPN I-LF
+reviews PROPN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PROPN I-LF
+Analyses PROPN I-LF
+( PUNCT O
+PRISMA PROPN B-AC
+) PUNCT O
+statement NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+Twenty NUM O
+- PUNCT O
+nine NUM O
+healthy ADJ O
+, PUNCT O
+moderately ADV O
+- PUNCT O
+active ADJ O
+men NOUN O
+( PUNCT O
+mean NOUN O
+± SYM O
+SD NOUN B-AC
+; PUNCT O
+age NOUN O
+24.5 NUM O
+± SYM O
+4.7 NUM O
+y NOUN O
+; PUNCT O
+body NOUN O
+mass NOUN O
+74.9 NUM O
+± SYM O
+10.8 NUM O
+kg NOUN O
+; PUNCT O
+height NOUN O
+179.7 NUM O
+± SYM O
+6.5 NUM O
+cm NOUN O
+) PUNCT O
+performed VERB O
+either CCONJ O
+resistance NOUN O
+- PUNCT O
+only ADV O
+training NOUN O
+( PUNCT O
+RT NOUN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+9 NUM O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+same ADJ O
+- PUNCT O
+day NOUN O
+concurrent ADJ O
+training NOUN O
+whereby SCONJ O
+high ADJ B-LF
+- PUNCT I-LF
+intensity NOUN I-LF
+interval NOUN I-LF
+training NOUN I-LF
+was AUX O
+performed VERB O
+either CCONJ O
+3 NUM O
+hours NOUN O
+before ADP O
+( PUNCT O
+HIIT+RT NOUN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+10 NUM O
+) PUNCT O
+or CCONJ O
+after ADP O
+resistance NOUN O
+training NOUN O
+( PUNCT O
+RT+HIIT NOUN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+10 NUM O
+) PUNCT O
+, PUNCT O
+for ADP O
+3 NUM O
+d.wk-1 NOUN B-AC
+over ADP O
+9 NUM O
+weeks NOUN O
+. PUNCT O
+
+Both CCONJ O
+CSR PROPN B-AC
+and CCONJ O
+SHM PROPN B-AC
+are AUX O
+initiated VERB O
+by ADP O
+and CCONJ O
+critically ADV O
+dependent ADJ O
+upon SCONJ O
+the DET O
+expression NOUN O
+of ADP O
+the DET O
+enzyme NOUN O
+activation NOUN B-LF
+- PUNCT I-LF
+induced VERB I-LF
+cytidine NOUN I-LF
+deaminase NOUN I-LF
+( PUNCT O
+AID PROPN B-AC
+) PUNCT O
+[ PUNCT O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+authors NOUN O
+said VERB O
+that SCONJ O
+they PRON O
+used VERB O
+the DET O
+Child PROPN B-LF
+Feeding PROPN I-LF
+Questionnaire PROPN I-LF
+for ADP I-LF
+adolescents NOUN I-LF
+( PUNCT O
+CFQ PROPN B-AC
+- PUNCT B-AC
+A PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+that SCONJ O
+, PUNCT O
+for ADP O
+this DET O
+study NOUN O
+, PUNCT O
+the DET O
+questionnaire NOUN O
+was AUX O
+translated VERB O
+into ADP O
+German ADJ O
+language NOUN O
+. PUNCT O
+
+cTN NOUN O
+= PUNCT O
+total ADJ O
+nitrogen NOUN O
+, PUNCT O
+TP NOUN B-AC
+= PUNCT O
+total ADJ B-LF
+phosphorus NOUN I-LF
+, PUNCT O
+TK NOUN B-AC
+= PUNCT O
+total ADJ B-LF
+potassium NOUN I-LF
+, PUNCT O
+AN NOUN B-AC
+= PUNCT O
+available ADJ B-LF
+nitrogen NOUN I-LF
+, PUNCT O
+AK NOUN B-AC
+= PUNCT O
+available ADJ B-LF
+potassium NOUN I-LF
+, PUNCT O
+AP NOUN B-AC
+= PUNCT O
+available ADJ B-LF
+phosphorus NOUN I-LF
+, PUNCT O
+SMC PROPN B-AC
+= PUNCT O
+soil NOUN B-LF
+moisture NOUN I-LF
+content NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+DI PROPN B-AC
+, PUNCT O
+Dietary PROPN B-LF
+Index PROPN I-LF
+; PUNCT O
+EPIC PROPN B-AC
+, PUNCT O
+European PROPN B-LF
+Prospective PROPN I-LF
+Investigation PROPN I-LF
+into ADP I-LF
+Cancer PROPN I-LF
+and CCONJ I-LF
+Nutrition PROPN I-LF
+; PUNCT O
+FSAm PROPN B-AC
+- PUNCT B-AC
+NPS PROPN B-AC
+, PUNCT O
+Nutrient PROPN O
+Profiling PROPN O
+System PROPN O
+of ADP O
+the DET O
+British PROPN O
+Food PROPN O
+Standards PROPN O
+Agency PROPN O
+( PUNCT O
+modified VERB O
+version NOUN O
+) PUNCT O
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+The DET O
+Field PROPN B-LF
+Health PROPN I-LF
+Services PROPN I-LF
+Information PROPN I-LF
+System PROPN I-LF
+( PUNCT O
+FHSIS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+43 NUM O
+] PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+managed VERB O
+by ADP O
+the DET O
+DOH PROPN B-AC
+, PUNCT O
+contains VERB O
+the DET O
+official ADJ O
+health NOUN O
+data NOUN O
+of ADP O
+the DET O
+Philippine ADJ O
+government NOUN O
+. PUNCT O
+
+To PART O
+determine VERB O
+which PRON O
+parameter NOUN O
+underlies VERB O
+predominantly ADV O
+the DET O
+slowness NOUN O
+of ADP O
+the DET O
+HRF NOUN B-AC
+in ADP O
+S1BF PROPN B-AC
+, PUNCT O
+we PRON O
+generated VERB O
+different ADJ O
+HRFs NOUN B-AC
+using VERB O
+prior ADJ O
+values NOUN O
+of ADP O
+the DET O
+hemodynamic ADJ O
+parameters NOUN O
+, PUNCT O
+with ADP O
+the DET O
+exception NOUN O
+of ADP O
+one NUM O
+parameter NOUN O
+, PUNCT O
+which PRON O
+was AUX O
+set VERB O
+to PART O
+the DET O
+value NOUN O
+estimated VERB O
+in ADP O
+S1BF PROPN B-AC
+( PUNCT O
+Figure PROPN O
+3B NUM O
+) PUNCT O
+. PUNCT O
+This PRON O
+allowed VERB O
+us PRON O
+to PART O
+conclude VERB O
+that SCONJ O
+the DET O
+strong ADJ O
+decrease NOUN O
+of ADP O
+the DET O
+autoregulation NOUN O
+constant NOUN O
+γ NOUN O
+, PUNCT O
+instantiating VERB O
+a DET O
+stable ADJ O
+feedback NOUN O
+of ADP O
+changes NOUN O
+in ADP O
+cerebral ADJ B-LF
+blood NOUN I-LF
+flow NOUN I-LF
+( PUNCT O
+CBF PROPN B-AC
+) PUNCT O
+on ADP O
+vasodilatatory ADJ O
+effects NOUN O
+( PUNCT O
+see VERB O
+Equation NOUN O
+1 NUM O
+) PUNCT O
+, PUNCT O
+is AUX O
+the DET O
+main ADJ O
+cause NOUN O
+of ADP O
+the DET O
+pathological ADJ O
+hemodynamics NOUN O
+observed VERB O
+. PUNCT O
+
+Subsequently ADV O
+, PUNCT O
+several ADJ O
+additional ADJ O
+compounds NOUN O
+have VERB O
+been AUX O
+reported VERB O
+to PART O
+specifically ADV O
+inhibit VERB O
+the DET O
+NLRP3 PROPN B-AC
+inflammasome NOUN O
+pathway NOUN O
+, PUNCT O
+but CCONJ O
+the DET O
+majority NOUN O
+of ADP O
+these DET O
+agents NOUN O
+have VERB O
+weak ADJ O
+activity NOUN O
+against ADP O
+the DET O
+NLRP3 PROPN B-AC
+inflammasome NOUN O
+pathway NOUN O
+( PUNCT O
+μM PROPN O
+IC50 NUM B-AC
+concentrations NOUN O
+) PUNCT O
+and CCONJ O
+may AUX O
+target VERB O
+nuclear ADJ B-LF
+factor NOUN I-LF
+κB PROPN I-LF
+( PUNCT O
+NF PROPN B-AC
+- NOUN B-AC
+κB PROPN B-AC
+) PUNCT O
+signaling NOUN O
+and CCONJ O
+other ADJ O
+immune ADJ O
+pathways NOUN O
+( PUNCT O
+reviewed VERB O
+in ADP O
+[ X O
+10 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+The DET O
+mammograms NOUN O
+were AUX O
+processed VERB O
+using VERB O
+a DET O
+volumetric ADJ B-LF
+breast NOUN I-LF
+density NOUN I-LF
+( PUNCT O
+VBD PROPN B-AC
+) PUNCT O
+measurement NOUN O
+software NOUN O
+( PUNCT O
+Volpara PROPN O
+) PUNCT O
+to PART O
+assess VERB O
+compression NOUN O
+force NOUN O
+, PUNCT O
+compression NOUN O
+pressure NOUN O
+, PUNCT O
+compressed ADJ B-LF
+breast NOUN I-LF
+thickness NOUN I-LF
+( PUNCT O
+CBT PROPN B-AC
+) PUNCT O
+, PUNCT O
+breast NOUN O
+volume NOUN O
+, PUNCT O
+VBD PROPN B-AC
+and CCONJ O
+MGD PROPN B-AC
+against ADP O
+breast NOUN O
+contact NOUN O
+area NOUN O
+. PUNCT O
+
+b X O
+CI NOUN B-AC
+; PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+. PUNCT O
+
+In ADP O
+order NOUN O
+to PART O
+have AUX O
+a DET O
+better ADJ O
+understanding NOUN O
+of ADP O
+how SCONJ O
+these DET O
+Hbs NOUN B-AC
+are AUX O
+affected VERB O
+by ADP O
+the DET O
+symbiosis NOUN O
+and CCONJ O
+their PRON O
+environment NOUN O
+, PUNCT O
+we PRON O
+evaluated VERB O
+hemoglobin NOUN B-LF
+gene NOUN O
+expression NOUN O
+in ADP O
+different ADJ O
+juvenile ADJ O
+clam NOUN O
+tissues NOUN O
+at ADP O
+the DET O
+RNA NOUN O
+level NOUN O
+, PUNCT O
+comparing VERB O
+two NUM O
+groups NOUN O
+of ADP O
+clams NOUN O
+living VERB O
+in ADP O
+two NUM O
+different ADJ O
+environments NOUN O
+, PUNCT O
+sulfide NOUN O
+- PUNCT O
+rich ADJ O
+and CCONJ O
+sulfide NOUN O
+- PUNCT O
+poor ADJ O
+. PUNCT O
+
+GT PROPN B-AC
+uses VERB O
+internet NOUN B-LF
+protocol NOUN I-LF
+( PUNCT O
+IP NOUN B-AC
+) PUNCT O
+addresses NOUN O
+from ADP O
+server NOUN O
+logs NOUN O
+to PART O
+assign VERB O
+the DET O
+origin NOUN O
+of ADP O
+web NOUN O
+search NOUN O
+queries NOUN O
+. PUNCT O
+
+ChIP NOUN B-AC
+- PUNCT O
+qPCR NOUN O
+, PUNCT O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+followed VERB O
+by ADP O
+quantitative ADJ O
+PCR NOUN O
+. PUNCT O
+
+AA PROPN O
+, PUNCT O
+amino NOUN O
+acid NOUN O
+; PUNCT O
+ACE2 PROPN B-AC
+, PUNCT O
+angiotensin NOUN B-LF
+converting VERB I-LF
+enzyme NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+COVID-19 PROPN B-AC
+, PUNCT O
+coronavirus NOUN B-LF
+disease NOUN I-LF
+2019 NUM I-LF
+; PUNCT O
+FP PROPN O
+, PUNCT O
+fusion NOUN O
+peptide NOUN O
+; PUNCT O
+HR1 PROPN O
+, PUNCT O
+heptad NOUN O
+repeat NOUN O
+1 NUM O
+; PUNCT O
+NTD PROPN O
+, PUNCT O
+N NOUN O
+- PUNCT O
+terminal ADJ O
+domain NOUN O
+; PUNCT O
+RBD PROPN B-AC
+, PUNCT O
+receptor NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+domain NOUN I-LF
+; PUNCT O
+RBM PROPN O
+, PUNCT O
+receptor NOUN O
+- PUNCT O
+binding VERB O
+motif NOUN O
+; PUNCT O
+S PROPN O
+, PUNCT O
+spike NOUN O
+; PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+, PUNCT O
+severe ADJ B-LF
+acute ADJ I-LF
+respiratory ADJ I-LF
+syndrome NOUN I-LF
+coronavirus NOUN I-LF
+2 NUM I-LF
+. PUNCT O
+
+The DET O
+open ADJ O
+structure NOUN O
+of ADP O
+P. NOUN O
+aeruginosa NOUN O
+lipase NOUN O
+was AUX O
+obtained VERB O
+from ADP O
+the DET O
+Protein PROPN B-LF
+Data PROPN I-LF
+Bank PROPN I-LF
+( PUNCT O
+PDB PROPN B-AC
+) PUNCT O
+. PUNCT O
+This PRON O
+was AUX O
+solvated VERB O
+in ADP O
+explicit ADJ O
+water NOUN O
+and CCONJ O
+energy NOUN O
+minimized VERB O
+. PUNCT O
+
+SD NOUN B-AC
+: PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+IQR PROPN B-AC
+, PUNCT O
+Interquartile ADJ B-LF
+range NOUN I-LF
+; PUNCT O
+SO2 PROPN O
+, PUNCT O
+oxygen NOUN O
+saturation NOUN O
+; PUNCT O
+BPS PROPN O
+, PUNCT O
+blood NOUN O
+pressure NOUN O
+systolic NOUN O
+; PUNCT O
+BPD PROPN O
+, PUNCT O
+blood NOUN O
+pressure NOUN O
+diastolic NOUN O
+; PUNCT O
+PR NOUN O
+, PUNCT O
+pulse NOUN O
+rate NOUN O
+; PUNCT O
+ED PROPN B-AC
+, PUNCT O
+emergency NOUN B-LF
+department NOUN I-LF
+; PUNCT O
+COPD PROPN B-AC
+, PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+WBC PROPN O
+, PUNCT O
+white ADJ O
+blood NOUN O
+cell NOUN O
+count NOUN O
+; PUNCT O
+ProADM PROPN B-AC
+, PUNCT O
+pro ADJ O
+- ADJ O
+adrenomedullin NOUN O
+; PUNCT O
+ICU PROPN B-AC
+, PUNCT O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+. PUNCT O
+
+bpMRI NOUN B-AC
+, PUNCT O
+biparametric ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+; PUNCT O
+NPV NOUN B-AC
+, PUNCT O
+negative ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+; PUNCT O
+PPV NOUN O
+, PUNCT O
+positive ADJ O
+predictive ADJ O
+value NOUN O
+; PUNCT O
+PSA PROPN B-AC
+, PUNCT O
+prostate NOUN B-LF
+specific ADJ I-LF
+antigen NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+WC PROPN O
+, PUNCT O
+waist NOUN O
+circumference NOUN O
+; PUNCT O
+FBG PROPN O
+, PUNCT O
+fasting ADJ O
+blood NOUN O
+glucose NOUN O
+; PUNCT O
+SBP PROPN B-AC
+, PUNCT O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+; PUNCT O
+AST PROPN B-AC
+, PUNCT O
+aspartate NOUN O
+aminotransferase NOUN O
+; PUNCT O
+ALT PROPN O
+, PUNCT O
+alanine NOUN O
+aminotransferase NOUN O
+; PUNCT O
+LDL PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+HDL PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+hs NOUN B-AC
+- PUNCT B-AC
+CRP PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+sensitivity NOUN I-LF
+C NOUN I-LF
+- PUNCT I-LF
+reactive NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+APRI PROPN B-AC
+, PUNCT O
+aspartate NOUN O
+aminotransferase NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+platelet NOUN O
+ratio NOUN O
+index NOUN O
+. PUNCT O
+
+Myofibroblasts NOUN O
+are AUX O
+characterized VERB O
+by ADP O
+excessive ADJ O
+production NOUN O
+of ADP O
+ECM PROPN B-AC
+components NOUN O
+and CCONJ O
+the DET O
+alpha NOUN B-LF
+- PUNCT I-LF
+smooth ADJ I-LF
+muscle NOUN I-LF
+actin NOUN I-LF
+( PUNCT O
+αSMA PROPN B-AC
+) PUNCT O
+containing VERB O
+stress NOUN O
+fiber NOUN O
+formation NOUN O
+which PRON O
+contributes VERB O
+to ADP O
+contraction NOUN O
+of ADP O
+the DET O
+tissue NOUN O
+[ PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+To PART O
+overcome VERB O
+these DET O
+difficulties NOUN O
+, PUNCT O
+we PRON O
+recently ADV O
+developed VERB O
+a DET O
+simple ADJ O
+measure NOUN O
+of ADP O
+intra ADJ O
+- PUNCT O
+tumor NOUN O
+genetic ADJ O
+heterogeneity NOUN O
+[ X O
+30,31 NUM O
+] PUNCT O
+based VERB O
+on ADP O
+whole ADJ B-LF
+- PUNCT I-LF
+exome NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT O
+WES PROPN B-AC
+) PUNCT O
+of ADP O
+tumor NOUN O
+and CCONJ O
+matched VERB O
+normal ADJ O
+DNA NOUN O
+. PUNCT O
+With SCONJ O
+WES PROPN B-AC
+expected VERB O
+to PART O
+play VERB O
+a DET O
+significant ADJ O
+role NOUN O
+soon ADV O
+in ADP O
+clinical ADJ O
+oncology NOUN O
+[ X O
+8,32 NUM O
+] PUNCT O
+, PUNCT O
+a DET O
+measure NOUN O
+of ADP O
+heterogeneity NOUN O
+based VERB O
+on ADP O
+this DET O
+technology NOUN O
+could AUX O
+be AUX O
+widely ADV O
+used VERB O
+in ADP O
+practice NOUN O
+. PUNCT O
+
+Next ADV O
+, PUNCT O
+we PRON O
+investigated VERB O
+the DET O
+effect NOUN O
+of ADP O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+( PUNCT O
+HFD PROPN B-AC
+) PUNCT O
+on ADP O
+metabolic ADJ O
+parameters NOUN O
+of ADP O
+TLR2 PROPN B-AC
+KO PROPN B-AC
+mice NOUN O
+. PUNCT O
+
+Edges NOUN O
+of ADP O
+the DET O
+phylogeny NOUN O
+were AUX O
+arbitrarily ADV O
+colored VERB O
+for ADP O
+illustrative ADJ O
+purposes NOUN O
+. PUNCT O
+( PUNCT O
+B NOUN O
+) PUNCT O
+The DET O
+distribution NOUN O
+of ADP O
+gold ADJ B-LF
+standard ADJ I-LF
+viral ADJ I-LF
+load NOUN I-LF
+( PUNCT O
+GSVL PROPN B-AC
+) PUNCT O
+over ADP O
+evolutionary ADJ O
+time NOUN O
+( PUNCT O
+as SCONJ O
+quantified VERB O
+by ADP O
+root NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+tip NOUN O
+distance NOUN O
+[ PUNCT O
+i.e. X O
+, PUNCT O
+distance NOUN O
+from ADP O
+the DET O
+common ADJ O
+ancestor NOUN O
+as SCONJ O
+assessed VERB O
+by ADP O
+the DET O
+phylogeny NOUN O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+chose VERB O
+the DET O
+best ADJ O
+cluster NOUN O
+number NOUN O
+( PUNCT O
+K NOUN O
+= SYM O
+4 NUM O
+) PUNCT O
+using VERB O
+subject ADJ O
+matter NOUN O
+expertise NOUN O
+based VERB O
+on ADP O
+a DET O
+combination NOUN O
+of ADP O
+factors NOUN O
+( PUNCT O
+log NOUN O
+- PUNCT O
+rank NOUN O
+p NOUN O
+< ADP O
+0.05 NUM O
+; PUNCT O
+S1 PROPN O
+Fig PROPN O
+and CCONJ O
+S2 PROPN O
+Table PROPN O
+): PUNCT O
+( PUNCT O
+i X O
+) PUNCT O
+significantly ADV O
+distinguishable ADJ O
+survival NOUN O
+rate NOUN O
+and CCONJ O
+cardiovascular ADJ O
+outcome NOUN O
+by ADP O
+Kaplan PROPN B-LF
+– PUNCT I-LF
+Meier PROPN I-LF
+( PUNCT O
+KM PROPN B-AC
+) PUNCT O
+estimator NOUN O
+with ADP O
+log NOUN O
+- PUNCT O
+rank NOUN O
+test NOUN O
+; PUNCT O
+and CCONJ O
+( PUNCT O
+ii X O
+) PUNCT O
+the DET O
+highest ADJ O
+number NOUN O
+of ADP O
+clusters NOUN O
+to PART O
+identify VERB O
+more ADJ O
+new ADJ O
+patient NOUN O
+subgroups NOUN O
+. PUNCT O
+
+Other ADJ O
+methodologies NOUN O
+have AUX O
+been AUX O
+proposed VERB O
+: PUNCT O
+adaptive ADJ O
+threshold NOUN O
+that PRON O
+allows VERB O
+consideration NOUN O
+of ADP O
+the DET O
+background NOUN O
+activity NOUN O
+or CCONJ O
+more ADV O
+sophisticated ADJ O
+methods NOUN O
+such ADJ O
+as ADP O
+fuzzy ADJ B-LF
+C PROPN I-LF
+mean NOUN I-LF
+( PUNCT O
+FCM PROPN B-AC
+) PUNCT O
+and CCONJ O
+fuzzy ADJ B-LF
+locally ADV I-LF
+adaptive ADJ I-LF
+Bayesian PROPN I-LF
+( PUNCT O
+FLAB PROPN B-AC
+) PUNCT O
+algorithms NOUN O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+To ADP O
+this DET O
+end NOUN O
+, PUNCT O
+we PRON O
+performed VERB O
+RNA NOUN B-LF
+interference NOUN I-LF
+( PUNCT O
+RNAi)-mediated NOUN B-AC
+knockdowns NOUN O
+of ADP O
+Hh NOUN B-AC
+and CCONJ O
+Dpp NOUN B-AC
+levels NOUN O
+by ADP O
+expressing VERB O
+RNAi NOUN B-AC
+lines NOUN O
+under ADP O
+the DET O
+control NOUN O
+of ADP O
+GMR PROPN B-AC
+- PUNCT O
+Gal4 PROPN O
+while SCONJ O
+simultaneously ADV O
+inducing VERB O
+apoptosis NOUN O
+using VERB O
+UAS PROPN O
+- PUNCT O
+rpr NOUN O
+. PUNCT O
+
+2D ADJ B-LF
+HeLa PROPN I-LF
+dataset NOUN I-LF
+
+Gene PROPN O
+completeness NOUN O
+was AUX O
+assessed VERB O
+by ADP O
+comparing VERB O
+sets NOUN O
+of ADP O
+core ADJ O
+eukaryotic ADJ O
+genes NOUN O
+to ADP O
+each DET O
+reference NOUN O
+assembly NOUN O
+using VERB O
+Core PROPN B-LF
+Eukaryotic PROPN I-LF
+Gene PROPN I-LF
+Mapping PROPN I-LF
+Approach PROPN I-LF
+( PUNCT O
+CEGMA PROPN B-AC
+) PUNCT O
+and CCONJ O
+Benchmarking VERB B-LF
+Universal PROPN I-LF
+Single PROPN I-LF
+- PUNCT I-LF
+Copy PROPN I-LF
+Orthologs PROPN I-LF
+( PUNCT O
+BUSCO PROPN B-AC
+) PUNCT O
+[ X O
+44,45 NUM O
+] PUNCT O
+. PUNCT O
+
+Human ADJ B-LF
+Exonic ADJ I-LF
+Evidence NOUN I-LF
+- PUNCT I-LF
+Based VERB I-LF
+Oligonucleotide NOUN I-LF
+( PUNCT O
+HEEBO PROPN B-AC
+) PUNCT O
+microarrays NOUN O
+( PUNCT O
+Microarrays NOUN O
+, PUNCT O
+Nashville PROPN O
+, PUNCT O
+Tennessee PROPN O
+) PUNCT O
+were AUX O
+used VERB O
+to PART O
+analyze VERB O
+changes NOUN O
+in ADP O
+gene NOUN O
+expression NOUN O
+within ADP O
+the DET O
+PFC PROPN B-AC
+. PUNCT O
+Four NUM O
+μg NOUN O
+of ADP O
+total ADJ O
+RNA NOUN O
+( PUNCT O
+RIN NOUN O
+> SYM O
+5.0 NUM O
+, PUNCT O
+A260/280 NUM O
+> SYM O
+2.0 NUM O
+) PUNCT O
+from ADP O
+PTSD PROPN B-AC
+( PUNCT O
+n NOUN O
+= SYM O
+6 NUM O
+) PUNCT O
+and CCONJ O
+matched VERB O
+control NOUN O
+human ADJ O
+samples NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+6 NUM O
+) PUNCT O
+were AUX O
+reverse ADV O
+transcribed VERB O
+into ADP O
+cDNA NOUN O
+and CCONJ O
+indirectly ADV O
+labeled VERB O
+with ADP O
+highly ADV O
+sensitive ADJ O
+fluorescent ADJ O
+technology NOUN O
+( PUNCT O
+Genisphere PROPN O
+, PUNCT O
+Hatfield PROPN O
+, PUNCT O
+Pennsylvania PROPN O
+) PUNCT O
+. PUNCT O
+
+LA PROPN B-AC
+: PUNCT O
+left ADJ B-LF
+atrium NOUN I-LF
+. PUNCT O
+
+Interestingly ADV O
+, PUNCT O
+the DET O
+transcriptomic ADJ O
+patterns NOUN O
+of ADP O
+the DET O
+brain NOUN O
+and CCONJ O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PBMCs NOUN B-AC
+) PUNCT O
+overlap VERB O
+, PUNCT O
+about ADV O
+80 NUM O
+% NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+6 X O
+. PUNCT O
+Discussion NOUN O
+: PUNCT O
+1 X O
+) PUNCT O
+Line NOUN O
+217 NUM O
+- SYM O
+220 NUM O
+: PUNCT O
+typo NOUN O
+and CCONJ O
+consider VERB O
+use NOUN O
+of ADP O
+standard ADJ O
+reference NOUN O
+for ADP O
+“ PUNCT O
+mean ADJ O
+difference NOUN O
+” PUNCT O
+( PUNCT O
+bias NOUN O
+) PUNCT O
+as ADP O
+the DET O
+quantified VERB O
+degree NOUN O
+of ADP O
+agreement NOUN O
+and CCONJ O
+“ PUNCT O
+limits NOUN B-LF
+of ADP I-LF
+agreement NOUN I-LF
+” PUNCT O
+( PUNCT O
+precision NOUN O
+) PUNCT O
+as ADP O
+SD NOUN B-AC
+and CCONJ O
+the DET O
+95 NUM O
+% NOUN O
+LOAs NOUN B-AC
+. PUNCT O
+2 X O
+) PUNCT O
+Line NOUN O
+240 NUM O
+– PUNCT O
+this PRON O
+statement NOUN O
+re ADP O
+: PUNCT O
+“ PUNCT O
+… PUNCT O
+although SCONJ O
+this PRON O
+was AUX O
+not PART O
+statistically ADV O
+significant ADJ O
+” PUNCT O
+was AUX O
+not PART O
+clear ADJ O
+to ADP O
+me PRON O
+. PUNCT O
+3 X O
+) PUNCT O
+Line NOUN O
+266 NUM O
+- SYM O
+270 NUM O
+: PUNCT O
+recommend VERB O
+using VERB O
+hypothermic ADJ O
+and CCONJ O
+febrile ADJ O
+range NOUN O
+temperatures NOUN O
+. PUNCT O
+
+In ADP O
+2003 NUM O
+and CCONJ O
+2009 NUM O
+, PUNCT O
+Carmichael PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+focused VERB O
+on ADP O
+both CCONJ O
+conotruncal ADJ O
+defects NOUN O
+: PUNCT O
+Tetralogy PROPN B-LF
+Of ADP I-LF
+Fallot PROPN I-LF
+( PUNCT O
+TOF PROPN B-AC
+) PUNCT O
+and CCONJ O
+dextro ADJ O
+- PUNCT O
+Transposition PROPN O
+of ADP O
+Great PROPN O
+Arteries PROPN O
+( PUNCT O
+dTGA)[9,27 NOUN O
+] PUNCT O
+. PUNCT O
+
+A DET O
+root NOUN B-LF
+- PUNCT I-LF
+mean NOUN I-LF
+– PUNCT I-LF
+squared VERB I-LF
+deviation NOUN I-LF
+( PUNCT O
+RMSD PROPN B-AC
+) PUNCT O
+value NOUN O
+, PUNCT O
+or CCONJ O
+any DET O
+linear ADJ O
+transformation NOUN O
+of ADP O
+this PRON O
+, PUNCT O
+often ADV O
+remains VERB O
+dependent ADJ O
+on ADP O
+the DET O
+number NOUN O
+of ADP O
+aligned VERB O
+residues NOUN O
+. PUNCT O
+
+Proportion NOUN O
+of ADP O
+patients NOUN O
+meeting VERB O
+at ADV O
+least ADV O
+one NUM O
+of ADP O
+nine NUM O
+indicators NOUN O
+of ADP O
+high ADJ O
+- PUNCT O
+risk NOUN O
+NSAID PROPN B-AC
+and CCONJ O
+anti ADJ O
+- PUNCT O
+platelet ADJ O
+prescribing NOUN O
+: PUNCT O
+prescription NOUN O
+of ADP O
+a DET O
+traditional ADJ O
+oral ADJ O
+NSAID PROPN B-AC
+or CCONJ O
+low ADJ O
+- PUNCT O
+dose NOUN O
+aspirin NOUN O
+in ADP O
+patients NOUN O
+with ADP O
+a DET O
+history NOUN O
+of ADP O
+peptic ADJ O
+ulceration NOUN O
+without ADP O
+co NOUN O
+- PUNCT O
+prescription NOUN O
+of ADP O
+gastro NOUN O
+- PUNCT O
+protection;traditional NOUN O
+oral ADJ O
+NSAID PROPN B-AC
+in ADP O
+patients NOUN O
+aged VERB O
+75 NUM O
+years NOUN O
+or CCONJ O
+over ADV O
+without ADP O
+co NOUN O
+- PUNCT O
+prescription NOUN O
+of ADP O
+gastro NOUN O
+- PUNCT O
+protection;traditional NOUN O
+oral ADJ O
+NSAID PROPN B-AC
+and CCONJ O
+aspirin NOUN O
+in ADP O
+patients NOUN O
+aged VERB O
+65 NUM O
+years NOUN O
+or CCONJ O
+over ADV O
+without ADP O
+co NOUN O
+- PUNCT O
+prescription NOUN O
+of ADP O
+gastro NOUN O
+- PUNCT O
+protection;aspirin NOUN O
+and CCONJ O
+clopidogrel NOUN O
+in ADP O
+patients NOUN O
+aged VERB O
+65 NUM O
+years NOUN O
+or CCONJ O
+over ADV O
+without ADP O
+co NOUN O
+- PUNCT O
+prescription NOUN O
+of ADP O
+gastro NOUN O
+- PUNCT O
+protection;warfarin NOUN O
+and CCONJ O
+traditional ADJ O
+oral ADJ O
+NSAID;warfarin PROPN B-AC
+and CCONJ O
+low ADJ O
+- PUNCT O
+dose NOUN O
+aspirin NOUN O
+or CCONJ O
+clopidogrel NOUN O
+without ADP O
+co NOUN O
+- PUNCT O
+prescription NOUN O
+of ADP O
+gastro NOUN O
+- PUNCT O
+protection;oral NOUN O
+NSAID PROPN B-AC
+in ADP O
+patients NOUN O
+with ADP O
+heart NOUN O
+failure;oral NOUN O
+NSAID PROPN B-AC
+in ADP O
+patients NOUN O
+prescribed VERB O
+both CCONJ O
+a DET O
+diuretic ADJ O
+and CCONJ O
+an DET O
+angiotensin NOUN B-LF
+- PUNCT I-LF
+converting VERB I-LF
+- PUNCT I-LF
+enzyme NOUN I-LF
+inhibitor NOUN I-LF
+( PUNCT O
+ACE PROPN B-AC
+- PUNCT B-AC
+I PROPN B-AC
+) PUNCT O
+or CCONJ O
+angiotensin NOUN B-LF
+receptor NOUN I-LF
+blocker NOUN I-LF
+( PUNCT O
+ARB);oral PROPN B-AC
+NSAID PROPN B-AC
+in ADP O
+patients NOUN O
+with ADP O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CKD PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+The DET O
+Rho PROPN O
+GTPases PROPN O
+exhibit VERB O
+guanine NOUN O
+nucleotide NOUN O
+– PUNCT O
+binding VERB O
+activity NOUN O
+and CCONJ O
+function VERB O
+as ADP O
+molecular ADJ O
+switches NOUN O
+, PUNCT O
+cycling VERB O
+between ADP O
+an DET O
+inactive ADJ O
+GDP(guanosine NOUN B-LF
+5′-bis NUM I-LF
+phosphate)-bound VERB I-LF
+form NOUN O
+and CCONJ O
+an DET O
+active ADJ O
+GTP PROPN B-AC
+- PUNCT O
+bound VERB O
+form NOUN O
+. PUNCT O
+
+Interactions NOUN O
+were AUX O
+tested VERB O
+between ADP O
+variables NOUN O
+in ADP O
+the DET O
+multivariable ADJ O
+model NOUN O
+, PUNCT O
+and CCONJ O
+all DET O
+variables NOUN O
+were AUX O
+tested VERB O
+for ADP O
+their PRON O
+inclusion NOUN O
+and CCONJ O
+interactions NOUN O
+with ADP O
+variables NOUN O
+in ADP O
+the DET O
+final ADJ O
+model NOUN O
+. PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+for ADP O
+the DET O
+model NOUN O
+fit NOUN O
+were AUX O
+calculated VERB O
+from ADP O
+the DET O
+standard ADJ B-LF
+error NOUN I-LF
+( PUNCT O
+SE NOUN B-AC
+) PUNCT O
+of ADP O
+the DET O
+fixed VERB O
+effects NOUN O
+. PUNCT O
+
+For ADP O
+PCA NOUN B-AC
+model NOUN O
+generation NOUN O
+tissue NOUN O
+type NOUN O
+- PUNCT O
+associated VERB O
+spectra NOUN O
+were AUX O
+selected VERB O
+with ADP O
+the DET O
+CytoSpec PROPN O
+™ NUM O
+software NOUN O
+and CCONJ O
+then ADV O
+ROIs NOUN B-AC
+( PUNCT O
+regions NOUN B-LF
+of ADP I-LF
+interest NOUN I-LF
+) PUNCT O
+were AUX O
+assigned VERB O
+. PUNCT O
+
+OR CCONJ B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+Drosophila PROPN O
+contains VERB O
+a DET O
+single ADJ O
+myosin NOUN B-LF
+heavy ADJ I-LF
+chain NOUN I-LF
+gene NOUN O
+, PUNCT O
+Mhc PROPN B-AC
+. PUNCT O
+
+Development NOUN O
+of ADP O
+an DET O
+effective ADJ O
+herpes NOUN B-LF
+simplex NOUN I-LF
+virus NOUN I-LF
+type NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+HSV-2 PROPN B-AC
+) PUNCT O
+prophylactic ADJ O
+vaccine NOUN O
+is AUX O
+a DET O
+global ADJ O
+priority NOUN O
+to PART O
+improve VERB O
+sexual ADJ O
+health NOUN O
+[ X O
+1,2 NUM O
+] PUNCT O
+. PUNCT O
+
+A DET O
+subset NOUN O
+of ADP O
+human ADJ O
+cancers NOUN O
+and CCONJ O
+immortalized ADJ O
+cell NOUN O
+lines NOUN O
+maintains VERB O
+telomeres NOUN O
+in ADP O
+the DET O
+absence NOUN O
+of ADP O
+telomerase NOUN O
+activity NOUN O
+using VERB O
+the DET O
+alternative ADJ B-LF
+lengthening NOUN I-LF
+of ADP I-LF
+telomeres NOUN I-LF
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+pathway NOUN O
+[ X O
+1–3 NUM O
+] PUNCT O
+. PUNCT O
+
+CKD PROPN B-AC
+primitive ADJ O
+diagnoses NOUN O
+were AUX O
+grouped VERB O
+as ADP O
+diabetic ADJ B-LF
+nephropathy NOUN I-LF
+( PUNCT O
+DN PROPN B-AC
+) PUNCT O
+, PUNCT O
+hypertensive ADJ B-LF
+nephropathy NOUN I-LF
+( PUNCT O
+HTN PROPN B-AC
+) PUNCT O
+, PUNCT O
+glomerulonephritis NOUN B-LF
+( PUNCT O
+GN PROPN B-AC
+) PUNCT O
+, PUNCT O
+tubulo ADJ B-LF
+- PUNCT I-LF
+intersitial ADJ I-LF
+nephritis NOUN I-LF
+( PUNCT O
+TIN PROPN B-AC
+) PUNCT O
+or CCONJ O
+polycystic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+PKD PROPN B-AC
+) PUNCT O
+. PUNCT O
+Diagnosis NOUN O
+of ADP O
+GN PROPN B-AC
+was AUX O
+biopsy NOUN O
+- PUNCT O
+proven VERB O
+for ADP O
+all DET O
+patients NOUN O
+. PUNCT O
+
+Initially ADV O
+, PUNCT O
+tidal ADJ O
+volume NOUN O
+was AUX O
+10 NUM O
+mL NOUN O
+x SYM O
+kg-1 NOUN O
+, PUNCT O
+PEEP NOUN B-AC
+5 NUM O
+cm NOUN O
+H2O NOUN O
+, PUNCT O
+respiratory ADJ O
+rate NOUN O
+25 NUM O
+x SYM O
+min-1 NOUN B-AC
+and CCONJ O
+inspired VERB B-LF
+oxygen NOUN I-LF
+fraction NOUN I-LF
+( PUNCT O
+FiO2 NOUN B-AC
+) PUNCT O
+0.3 NUM O
+. PUNCT O
+
+A DET O
+NanoAnalyzer PROPN O
+N30 PROPN O
+instrument NOUN O
+equipped VERB O
+with ADP O
+a DET O
+dual ADJ O
+488/640 NUM O
+nm NOUN O
+laser NOUN O
+and CCONJ O
+single ADJ B-LF
+- PUNCT I-LF
+photon NOUN I-LF
+counting NOUN I-LF
+avalanche NOUN I-LF
+photodiodes NOUN I-LF
+detectors NOUN I-LF
+( PUNCT O
+SPCM PROPN B-AC
+APDs NOUN O
+) PUNCT O
+was AUX O
+used VERB O
+for ADP O
+detection NOUN O
+of ADP O
+the DET O
+EV PROPN B-AC
+isolates NOUN O
+. PUNCT O
+
+EGFP PROPN O
+, PUNCT O
+enhanced ADJ O
+green ADJ O
+fluorescent ADJ O
+protein NOUN O
+; PUNCT O
+iLID PROPN B-AC
+, PUNCT O
+improved ADJ B-LF
+light NOUN I-LF
+- PUNCT I-LF
+induced VERB I-LF
+dimer NOUN I-LF
+; PUNCT O
+MTOC PROPN B-AC
+, PUNCT O
+microtubule NOUN B-LF
+organizing VERB I-LF
+center NOUN I-LF
+; PUNCT O
+PACT PROPN B-AC
+, PUNCT O
+pericentrin NOUN B-LF
+- PUNCT I-LF
+AKAP-450 NOUN I-LF
+containing VERB I-LF
+targeting NOUN I-LF
+; PUNCT O
+SspB PROPN B-AC
+, PUNCT O
+Stringent ADJ B-LF
+starvation NOUN I-LF
+protein NOUN I-LF
+B PROPN I-LF
+; PUNCT O
+UAS PROPN O
+, PUNCT O
+upstream ADJ O
+activation NOUN O
+sequence NOUN O
+. PUNCT O
+
+HA PROPN B-AC
+, PUNCT O
+haemagglutinin NOUN B-LF
+; PUNCT O
+HD PROPN B-AC
+- PUNCT B-AC
+MAP PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+microarray NOUN I-LF
+patch NOUN I-LF
+; PUNCT O
+IM PROPN B-AC
+, PUNCT O
+intramuscular NOUN B-LF
+. PUNCT O
+
+Here ADV O
+we PRON O
+set VERB O
+out ADP O
+to PART O
+find VERB O
+an DET O
+alternative ADJ O
+sampling NOUN O
+technique NOUN O
+for ADP O
+collecting VERB O
+outdoor ADJ O
+mosquitoes NOUN O
+in ADP O
+Lao PROPN O
+PDR PROPN B-AC
+. PUNCT O
+In ADP O
+the DET O
+first ADJ O
+experiment NOUN O
+we PRON O
+compared VERB O
+the DET O
+human NOUN B-LF
+- PUNCT I-LF
+baited VERB I-LF
+double ADJ I-LF
+net NOUN I-LF
+trap NOUN O
+( PUNCT O
+HDN PROPN B-AC
+) PUNCT O
+, PUNCT O
+CDC PROPN B-AC
+light ADJ O
+trap NOUN O
+, PUNCT O
+BG PROPN B-AC
+Sentinel PROPN O
+trap NOUN O
+and CCONJ O
+Suna PROPN O
+trap NOUN O
+. PUNCT O
+
+At ADP O
+the DET O
+organelle NOUN O
+level NOUN O
+, PUNCT O
+if SCONJ O
+the DET O
+lysosomal ADJ O
+membrane NOUN O
+is AUX O
+mildly ADV O
+damaged VERB O
+by ADP O
+insults NOUN O
+like ADP O
+lysosomotropic ADJ O
+compounds NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+L NOUN B-LF
+- PUNCT I-LF
+leucyl NOUN I-LF
+- PUNCT I-LF
+L NOUN I-LF
+- PUNCT I-LF
+leucine NOUN I-LF
+methyl NOUN I-LF
+ester NOUN I-LF
+( PUNCT O
+LLOMe PROPN B-AC
+) PUNCT O
+or CCONJ O
+iron NOUN O
+- PUNCT O
+dependent ADJ O
+oxidative ADJ O
+stress NOUN O
+, PUNCT O
+the DET O
+endosomal ADJ B-LF
+sorting VERB I-LF
+complexes NOUN I-LF
+required VERB I-LF
+for ADP I-LF
+transport NOUN I-LF
+( PUNCT O
+ESCRT PROPN B-AC
+) PUNCT O
+machinery NOUN O
+can AUX O
+be AUX O
+recruited VERB O
+to PART O
+the DET O
+lysosome NOUN O
+surface NOUN O
+to PART O
+repair VERB O
+the DET O
+membrane NOUN O
+[ X O
+16–18 NUM O
+] PUNCT O
+. PUNCT O
+
+As SCONJ O
+T PROPN O
+cell NOUN O
+migration NOUN O
+is AUX O
+activated VERB O
+by ADP O
+several ADJ O
+chemokines NOUN O
+, PUNCT O
+leading VERB O
+to ADP O
+different ADJ O
+responses NOUN O
+[ PUNCT O
+11 NUM O
+] PUNCT O
+, PUNCT O
+we PRON O
+also ADV O
+tested VERB O
+the DET O
+effect NOUN O
+of ADP O
+lactate NOUN O
+on ADP O
+chemokine NOUN B-LF
+( PUNCT I-LF
+C NOUN I-LF
+- PUNCT I-LF
+C NOUN I-LF
+motif NOUN I-LF
+) PUNCT I-LF
+ligand NOUN I-LF
+( PUNCT O
+CCL)5 NOUN B-AC
+- PUNCT O
+induced VERB O
+chemotaxis NOUN O
+. PUNCT O
+
+Key ADJ O
+: PUNCT O
+IHC PROPN B-AC
+, PUNCT O
+immunohistochemistry NOUN B-LF
+; PUNCT O
+INMB PROPN O
+, PUNCT O
+incremental ADJ O
+net ADJ O
+monetary ADJ O
+benefit NOUN O
+( PUNCT O
+presented VERB O
+per ADP O
+proband NOUN O
+) PUNCT O
+; PUNCT O
+QALY PROPN B-AC
+, PUNCT O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+years NOUN I-LF
+; PUNCT O
+WTP PROPN O
+, PUNCT O
+willingness NOUN O
+- PUNCT O
+to PART O
+- PUNCT O
+pay VERB O
+; PUNCT O
+S5 PROPN O
+Appendix NOUN O
+gives VERB O
+details NOUN O
+of ADP O
+all DET O
+parameter NOUN O
+abbreviations NOUN O
+. PUNCT O
+
+For ADP O
+each DET O
+block NOUN O
+group NOUN O
+, PUNCT O
+we PRON O
+calculated VERB O
+measures NOUN O
+of ADP O
+accessibility NOUN O
+to ADP O
+health NOUN O
+facilities NOUN O
+, PUNCT O
+including VERB O
+minimum ADJ O
+distance NOUN O
+from ADP O
+the DET O
+the DET O
+geographic ADJ O
+centers NOUN O
+of ADP O
+each DET O
+block NOUN O
+group NOUN O
+to ADP O
+hospitals NOUN O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+, PUNCT O
+pharmacies NOUN O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+, PUNCT O
+federally ADV B-LF
+qualified ADJ I-LF
+health NOUN I-LF
+centers NOUN I-LF
+( PUNCT O
+FQHCs PROPN B-AC
+) PUNCT O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+, PUNCT O
+buprenorphine NOUN O
+prescribing VERB O
+physicians NOUN O
+, PUNCT O
+and CCONJ O
+Substance PROPN B-LF
+Abuse PROPN I-LF
+and CCONJ I-LF
+Mental PROPN I-LF
+Health PROPN I-LF
+Services PROPN I-LF
+Administration PROPN I-LF
+( PUNCT O
+SAMHSA PROPN B-AC
+) PUNCT O
+Opioid PROPN B-LF
+Treatment PROPN I-LF
+Programs PROPN I-LF
+( PUNCT O
+OTPs PROPN B-AC
+) PUNCT O
+[ PUNCT O
+32 NUM O
+] PUNCT O
+; PUNCT O
+and CCONJ O
+the DET O
+distance NOUN O
+to ADP O
+the DET O
+closest ADJ O
+fire NOUN O
+department NOUN O
+[ PUNCT O
+33 NUM O
+] PUNCT O
+. PUNCT O
+
+Briefly ADV O
+, PUNCT O
+we PRON O
+acquired VERB O
+the DET O
+15N NUM O
+backbone NOUN O
+relaxation NOUN O
+data NOUN O
+T1 NOUN O
+, PUNCT O
+T2 NOUN O
+, PUNCT O
+and CCONJ O
+[ X O
+1H]-15N NOUN O
+steady ADJ O
+- PUNCT O
+state NOUN O
+heteronuclear ADJ O
+Nuclear PROPN O
+Overhauser PROPN O
+Effect PROPN O
+( PUNCT O
+hNOE PROPN B-AC
+) PUNCT O
+( PUNCT O
+S2 PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+Carr PROPN B-LF
+– PUNCT I-LF
+Purcell PROPN I-LF
+– PUNCT I-LF
+Meiboom PROPN I-LF
+– PUNCT I-LF
+Gill PROPN I-LF
+( PUNCT O
+CPMG PROPN B-AC
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+relaxation NOUN O
+dispersion NOUN O
+data NOUN O
+for ADP O
+the DET O
+NTD PROPN B-AC
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+50 NUM O
+μM NOUN O
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+5 NUM O
+mM NOUN O
+sodium NOUN O
+phosphate NOUN O
+buffer NOUN O
+( PUNCT O
+pH NOUN O
+6.0 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+top ADJ O
+- PUNCT O
+view NOUN O
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+MLA PROPN B-AC
+( PUNCT O
+Fig NOUN O
+4A NOUN O
+) PUNCT O
+shows VERB O
+that SCONJ O
+the DET O
+MLA PROPN B-AC
+- PUNCT O
+protein NOUN O
+interactions NOUN O
+mimic VERB O
+the DET O
+substrate NOUN O
+analogue NOUN O
+barbiturate NOUN B-LF
+( PUNCT O
+BAR)-protein NOUN B-AC
+interactions NOUN O
+at ADP O
+A NOUN O
+and CCONJ O
+B NOUN O
+carbonyl NOUN O
+- PUNCT O
+binding VERB O
+sites NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
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+days NOUN O
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+AUC0–24ss NOUN B-AC
+= PUNCT O
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+0–24 NUM O
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+- PUNCT B-AC
+TB PROPN B-AC
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+- PUNCT I-LF
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+tuberculosis NOUN I-LF
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+
+AD PROPN B-AC
+- PUNCT B-AC
+CM PROPN B-AC
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+Alzheimer PROPN B-LF
+disease NOUN I-LF
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+signature NOUN I-LF
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+glucose NOUN I-LF
+metabolism NOUN I-LF
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+- PUNCT B-AC
+CT PROPN B-AC
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+Alzheimer PROPN B-LF
+disease NOUN I-LF
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+signature NOUN I-LF
+cortical ADJ I-LF
+thickness NOUN I-LF
+; PUNCT O
+B NOUN O
+, PUNCT O
+unstandardized ADJ O
+regression NOUN O
+coefficient NOUN O
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+, PUNCT O
+standard ADJ B-LF
+drink NOUN I-LF
+; PUNCT O
+SUVR NOUN B-AC
+, PUNCT O
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+uptake NOUN I-LF
+value NOUN I-LF
+ratio NOUN I-LF
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+WMH PROPN B-AC
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+matter NOUN I-LF
+hyperintensity NOUN I-LF
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+Studies NOUN O
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+lamin NOUN O
+A NOUN O
+/ SYM O
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+mouse NOUN O
+models NOUN O
+indicate VERB O
+that SCONJ O
+loss NOUN O
+of ADP O
+function NOUN O
+of ADP O
+lamin NOUN O
+A NOUN O
+/ SYM O
+C NOUN O
+proteins NOUN O
+also ADV O
+develops VERB O
+some PRON O
+of ADP O
+the DET O
+laminopathies NOUN O
+, PUNCT O
+including VERB O
+muscular ADJ O
+dystrophy NOUN O
+, PUNCT O
+dilated VERB B-LF
+cardiomyopathy NOUN I-LF
+( PUNCT O
+DCM PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+Charcot PROPN B-LF
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+– PUNCT I-LF
+Tooth PROPN I-LF
+disorder NOUN I-LF
+, PUNCT I-LF
+type NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+CMT2 NOUN B-AC
+) PUNCT O
+[ PUNCT O
+14,23,24 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
+study NOUN O
+is AUX O
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+as ADP O
+per ADP O
+the DET O
+Consolidated PROPN B-LF
+Health PROPN I-LF
+Economic PROPN I-LF
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+Reporting PROPN I-LF
+Standards PROPN I-LF
+( PUNCT O
+CHEERS PROPN B-AC
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+( PUNCT O
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+Checklist PROPN O
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+To PART O
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+[ X O
+FDR NOUN B-AC
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+= SYM O
+0.01 NUM O
+) PUNCT O
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+
+When SCONJ O
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+, PUNCT O
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+following ADJ O
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+( PUNCT O
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+, PUNCT O
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+( PUNCT O
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+, PUNCT O
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+( PUNCT O
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+( PUNCT O
+DAPI PROPN B-AC
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+1 NUM O
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+( PUNCT O
+1–1,000 NUM O
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+) PUNCT O
+, PUNCT O
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+( PUNCT O
+0.2 NUM O
+% PUNCT O
+) PUNCT O
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+L NOUN O
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+these DET O
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+
+BW PROPN B-AC
+body NOUN B-LF
+weight NOUN I-LF
+; PUNCT O
+FPG PROPN O
+Fasting NOUN O
+plasma NOUN O
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+test NOUN I-LF
+; PUNCT O
+ITT PROPN B-AC
+insulin NOUN B-LF
+tolerance NOUN I-LF
+test NOUN I-LF
+; PUNCT O
+TG NOUN B-AC
+triglyceride NOUN B-LF
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+Alanine PROPN B-LF
+Aminotransferase NOUN I-LF
+. PUNCT O
+
+Values NOUN O
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+median NOUN O
+( PUNCT O
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+
+The DET O
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+in ADP O
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+- PUNCT O
+of ADP O
+- PUNCT O
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+, PUNCT O
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+, PUNCT O
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+] PUNCT O
+. PUNCT O
+
+cDNA NOUN B-AC
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+[ X O
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+] PUNCT O
+) PUNCT O
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+cloned VERB O
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+cDNA NOUN B-AC
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+the DET O
+pGEX6P-3 PROPN O
+plasmid NOUN O
+( PUNCT O
+GE PROPN O
+Healthcare PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+and CCONJ O
+expressed VERB O
+as ADP O
+GST PROPN B-AC
+- PUNCT O
+fusion NOUN O
+proteins NOUN O
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+- PUNCT O
+efficiency NOUN O
+BL21(DE3 PROPN O
+) PUNCT O
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+, PUNCT O
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+. PUNCT O
+
+The DET O
+measures NOUN O
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+, PUNCT O
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+( PUNCT O
+MOR PROPN B-AC
+) PUNCT O
+, PUNCT O
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+Variance PROPN I-LF
+( PUNCT O
+PCV PROPN B-AC
+) PUNCT O
+. PUNCT O
+ICC PROPN B-AC
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+used VERB O
+to PART O
+explain VERB O
+cluster NOUN O
+variation NOUN O
+while SCONJ O
+MOR PROPN B-AC
+is AUX O
+a DET O
+measure NOUN O
+of ADP O
+unexplained ADJ O
+cluster NOUN O
+heterogeneity NOUN O
+[ PUNCT O
+27 NUM O
+] PUNCT O
+. PUNCT O
+
+However ADV O
+there PRON O
+is VERB O
+an DET O
+attractive ADJ O
+, PUNCT O
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+use NOUN O
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+) PUNCT O
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+] X O
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+( PUNCT O
+TiO2 NOUN O
+) PUNCT O
+, PUNCT O
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+
+Overall ADV O
+, PUNCT O
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+- NOUN O
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+
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+
+This DET O
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+TAG PROPN B-AC
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+- PUNCT O
+chain NOUN O
+acyl NOUN O
+- PUNCT O
+coenzyme NOUN O
+A NOUN O
+( PUNCT O
+CoA PROPN O
+) PUNCT O
+molecules NOUN O
+as ADP O
+acyl NOUN O
+donors NOUN O
+and CCONJ O
+long ADJ O
+- PUNCT O
+chain NOUN O
+fatty ADJ O
+alcohols NOUN O
+or CCONJ O
+diacylglycerols NOUN B-LF
+( PUNCT O
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+
+The DET O
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+( PUNCT O
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+[ X O
+14–16 NUM O
+] PUNCT O
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+17,18 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
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+Reporting PROPN I-LF
+Trials PROPN I-LF
+( PUNCT O
+CONSORT PROPN B-AC
+) PUNCT O
+guideline NOUN O
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+. PUNCT O
+
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+- PUNCT I-LF
+care NOUN I-LF
+provider NOUN I-LF
+. PUNCT O
+
+The DET O
+laboratory NOUN O
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+) PUNCT O
+, PUNCT O
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+( PUNCT O
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+) PUNCT O
+, PUNCT O
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+( PUNCT O
+HbA1c NOUN B-AC
+) PUNCT O
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+
+Access NOUN O
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+Brazil PROPN O
+) PUNCT O
+and CCONJ O
+3-(4,5 NUM B-LF
+- PUNCT I-LF
+dimethylthiazol-2 NOUN I-LF
+- PUNCT I-LF
+yl)-2,5 NUM I-LF
+- PUNCT I-LF
+diphenyltetrazolium NOUN I-LF
+bromide NOUN I-LF
+( PUNCT O
+MTT PROPN B-AC
+) PUNCT O
+was AUX O
+from ADP O
+Calbiochem PROPN O
+Corp. PROPN O
+( PUNCT O
+La PROPN O
+Jolla PROPN O
+, PUNCT O
+CA PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+primary ADJ O
+endpoint NOUN O
+was AUX O
+the DET O
+RFS PROPN B-AC
+, PUNCT O
+the DET O
+exposure NOUN O
+variable NOUN O
+was AUX O
+the DET O
+PMI PROPN B-AC
+, PUNCT O
+and CCONJ O
+the DET O
+overall ADJ B-LF
+survival NOUN I-LF
+( PUNCT O
+OS PROPN B-AC
+) PUNCT O
+and CCONJ O
+cancer NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+survival NOUN I-LF
+( PUNCT O
+CSS PROPN B-AC
+) PUNCT O
+were AUX O
+secondary ADJ O
+endpoints NOUN O
+. PUNCT O
+
+CTD PROPN B-AC
+, PUNCT O
+C NOUN B-LF
+- PUNCT I-LF
+terminal ADJ I-LF
+domain NOUN I-LF
+; PUNCT O
+HNH NOUN B-AC
+, PUNCT O
+HNH NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+nuclease NOUN I-LF
+; PUNCT O
+NUC PROPN B-AC
+lobe NOUN B-AC
+, PUNCT O
+nuclease NOUN B-LF
+lobe NOUN I-LF
+; PUNCT O
+PAM PROPN B-AC
+, PUNCT O
+protospacer NOUN B-LF
+adjacent ADJ I-LF
+motif NOUN I-LF
+; PUNCT O
+REC PROPN B-AC
+lobe NOUN B-AC
+, PUNCT O
+α ADJ B-LF
+- PUNCT I-LF
+helical ADJ I-LF
+recognition NOUN I-LF
+lobe NOUN I-LF
+; PUNCT O
+RuvC NOUN B-AC
+, PUNCT O
+RuvC NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+nuclease NOUN I-LF
+; PUNCT O
+sgRNA NOUN B-AC
+, PUNCT O
+single ADJ B-LF
+- PUNCT I-LF
+guide NOUN I-LF
+RNA NOUN I-LF
+; PUNCT O
+SpCas9 PROPN B-AC
+, PUNCT O
+Streptococcus PROPN B-LF
+pyogenes NOUN I-LF
+Cas9 PROPN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild NOUN B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+The DET O
+auditory ADJ B-LF
+nerves NOUN I-LF
+( PUNCT O
+AN PROPN B-AC
+) PUNCT O
+are AUX O
+modeled VERB O
+as ADP O
+leaky ADJ O
+integrate VERB O
+- PUNCT O
+and CCONJ O
+- PUNCT O
+fire VERB O
+neurons NOUN O
+with ADP O
+stochastically ADV O
+variable ADJ O
+absolute ADJ O
+and CCONJ O
+relative ADJ O
+refractory ADJ O
+times NOUN O
+, PUNCT O
+latency NOUN O
+and CCONJ O
+jitter NOUN O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+a DET O
+neuronal ADJ O
+membrane NOUN O
+noise NOUN O
+. PUNCT O
+
+CVD NOUN B-AC
+, PUNCT O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+; PUNCT O
+HR NOUN O
+, PUNCT O
+hazard NOUN O
+ratio NOUN O
+; PUNCT O
+IR NOUN O
+, PUNCT O
+incidence NOUN O
+rate NOUN O
+. PUNCT O
+
+TEM PROPN B-AC
+, PUNCT O
+transmission NOUN B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+; PUNCT O
+Tf PROPN B-AC
+- PUNCT B-AC
+LPA PROPN B-AC
+, PUNCT O
+Top PROPN B-LF
+- PUNCT I-LF
+Fluor NOUN I-LF
+lysophosphatidic NOUN I-LF
+acid NOUN I-LF
+. PUNCT O
+
+Reliable ADJ O
+estimates NOUN O
+of ADP O
+measures NOUN O
+of ADP O
+mortality NOUN O
+from ADP O
+severe ADJ B-LF
+acute ADJ I-LF
+respiratory ADJ I-LF
+syndrome NOUN I-LF
+coronavirus NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+) PUNCT O
+infection NOUN O
+are AUX O
+needed VERB O
+to PART O
+understand VERB O
+clinical ADJ O
+prognosis NOUN O
+, PUNCT O
+to PART O
+plan VERB O
+healthcare NOUN O
+capacity NOUN O
+, PUNCT O
+and CCONJ O
+for ADP O
+epidemic NOUN O
+forecasting NOUN O
+. PUNCT O
+
+ESCC PROPN B-AC
+, PUNCT O
+esophageal ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+; PUNCT O
+HC PROPN O
+, PUNCT O
+healthy ADJ O
+control NOUN O
+; PUNCT O
+HRA PROPN O
+, PUNCT O
+health NOUN O
+risk NOUN O
+appraisal NOUN O
+; PUNCT O
+HPSCC PROPN B-AC
+, PUNCT O
+hypopharyngeal ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+; PUNCT O
+SCC PROPN O
+, PUNCT O
+squamous ADJ O
+cell NOUN O
+carcinoma NOUN O
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+. PUNCT O
+
+TUN PROPN B-AC
+and CCONJ O
+EVN PROPN B-AC
+are AUX O
+both PRON O
+involved ADJ O
+in ADP O
+protein NOUN O
+N NOUN O
+- PUNCT O
+glycosylation NOUN O
+in ADP O
+the DET O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT O
+ER PROPN B-AC
+) PUNCT O
+and CCONJ O
+encode VERB O
+a DET O
+putative ADJ O
+uridine NOUN B-LF
+diphosphate NOUN I-LF
+( PUNCT O
+UDP)-glycosyltransferase NOUN B-AC
+superfamily NOUN O
+protein NOUN O
+and CCONJ O
+a DET O
+dolichol NOUN O
+kinase NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+Statistical ADJ O
+heterogeneity NOUN B-LF
+( PUNCT O
+I2 NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+IL6 PROPN B-AC
+makes VERB O
+direct ADJ O
+interaction NOUN O
+with ADP O
+NFkB PROPN O
+( PUNCT O
+complex NOUN O
+) PUNCT O
+, PUNCT O
+P38 PROPN O
+MAPK PROPN O
+, PUNCT O
+and CCONJ O
+TNF PROPN O
+. PUNCT O
+Akt PROPN O
+/ SYM O
+PI3 PROPN O
+K PROPN O
+was AUX O
+also ADV O
+reported VERB O
+in ADP O
+our PRON O
+previous ADJ O
+findings NOUN O
+, PUNCT O
+for ADP O
+which PRON O
+it PRON O
+was AUX O
+an DET O
+important ADJ O
+member NOUN O
+of ADP O
+a DET O
+network NOUN O
+formed VERB O
+by ADP O
+genes NOUN O
+of ADP O
+metastatic ADJ B-LF
+clear ADJ I-LF
+cell NOUN I-LF
+renal ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+( PUNCT O
+mccRCC PROPN B-AC
+) PUNCT O
+cell NOUN O
+line NOUN O
+Caki-1 PROPN O
+[ PUNCT O
+97 NUM O
+] PUNCT O
+. PUNCT O
+
+Systemic ADJ O
+inflammation NOUN O
+is AUX O
+often ADV O
+reflected VERB O
+by ADP O
+increased VERB O
+circulating VERB O
+C NOUN B-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+CRP PROPN B-AC
+) PUNCT O
+levels NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AF PROPN B-AC
+, PUNCT O
+atrial ADJ B-LF
+fibrillation NOUN I-LF
+; PUNCT O
+ECG PROPN B-AC
+, PUNCT O
+electrocardiogram NOUN B-LF
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+sBP NOUN B-AC
+, PUNCT O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+. PUNCT O
+
+It PRON O
+is AUX O
+therefore ADV O
+liable ADJ O
+to PART O
+capture VERB O
+cases NOUN O
+of ADP O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CKD PROPN B-AC
+) PUNCT O
+with ADP O
+relatively ADV O
+mild ADJ O
+creatinine NOUN O
+elevations NOUN O
+. PUNCT O
+
+Further ADJ O
+p53 NOUN O
+epigenetic ADJ O
+profiling NOUN O
+was AUX O
+done VERB O
+by ADP O
+Methylation NOUN B-LF
+specific ADJ I-LF
+PCR NOUN I-LF
+( PUNCT O
+MS PROPN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+) PUNCT O
+and CCONJ O
+western ADJ O
+blotting NOUN O
+by ADP O
+using VERB O
+p53 NOUN O
+acetylation NOUN O
+specific ADJ O
+antibodies NOUN O
+. PUNCT O
+
+Weiner PROPN O
+, PUNCT O
+MD PROPN O
+. PUNCT O
+The DET O
+primary ADJ O
+goal NOUN O
+of ADP O
+ADNI PROPN B-AC
+has AUX O
+been AUX O
+to ADP O
+test VERB O
+whether SCONJ O
+serial ADJ O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+MRI PROPN B-AC
+) PUNCT O
+, PUNCT O
+positron NOUN B-LF
+emission NOUN I-LF
+tomography NOUN I-LF
+( PUNCT O
+PET PROPN B-AC
+) PUNCT O
+, PUNCT O
+other ADJ O
+biological ADJ O
+markers NOUN O
+, PUNCT O
+and CCONJ O
+clinical ADJ O
+and CCONJ O
+neuropsychological ADJ O
+assessment NOUN O
+can AUX O
+be AUX O
+combined VERB O
+to ADP O
+measure VERB O
+the DET O
+progression NOUN O
+of ADP O
+mild ADJ B-LF
+cognitive ADJ I-LF
+impairment NOUN I-LF
+( PUNCT O
+MCI PROPN B-AC
+) PUNCT O
+and CCONJ O
+early ADJ O
+Alzheimer PROPN B-LF
+’s PART I-LF
+disease NOUN I-LF
+( PUNCT O
+AD PROPN B-AC
+) PUNCT O
+. PUNCT O
+For ADP O
+up ADP O
+- PUNCT O
+to ADP O
+- PUNCT O
+date NOUN O
+information NOUN O
+, PUNCT O
+see VERB O
+www.adni-info.org X O
+. PUNCT O
+
+England PROPN O
+has VERB O
+a DET O
+national ADJ O
+HIV PROPN B-LF
+self NOUN I-LF
+- PUNCT I-LF
+sampling VERB I-LF
+( PUNCT O
+HIVSS PROPN B-AC
+) PUNCT O
+service NOUN O
+, PUNCT O
+where SCONJ O
+an DET O
+individual NOUN O
+takes VERB O
+a DET O
+sample NOUN O
+which PRON O
+they PRON O
+then ADV O
+post VERB O
+back ADV O
+to ADP O
+the DET O
+laboratory NOUN O
+where SCONJ O
+it PRON O
+is AUX O
+processed VERB O
+and CCONJ O
+the DET O
+patient NOUN O
+is AUX O
+contacted VERB O
+with ADP O
+the DET O
+result NOUN O
+[ X O
+8 NUM O
+, PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+
+EGFR PROPN B-AC
+: PUNCT O
+epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+ICER PROPN B-AC
+: PUNCT O
+incremental ADJ B-LF
+cost NOUN I-LF
+- PUNCT I-LF
+effectiveness NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+QALE PROPN B-AC
+: PUNCT O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+expectancy NOUN I-LF
+; PUNCT O
+QALY PROPN B-AC
+: PUNCT O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+year NOUN I-LF
+; PUNCT O
+TKI PROPN B-AC
+: PUNCT O
+tyrosine NOUN B-LF
+kinase NOUN I-LF
+inhibitor NOUN I-LF
+
+Alb NOUN O
+, PUNCT O
+albumin NOUN O
+; PUNCT O
+APOA2 PROPN B-AC
+, PUNCT O
+apolipoprotein NOUN B-LF
+A2 PROPN I-LF
+; PUNCT O
+Cont PROPN O
+, PUNCT O
+control NOUN O
+; PUNCT O
+E NOUN B-AC
+- PUNCT B-AC
+cad NOUN B-AC
+, PUNCT O
+E NOUN B-LF
+- PUNCT I-LF
+cadherin NOUN I-LF
+; PUNCT O
+EF1 PROPN B-AC
+, PUNCT O
+Human NOUN B-LF
+elongation NOUN I-LF
+factor-1 NOUN I-LF
+alpha NOUN I-LF
+promoter NOUN I-LF
+; PUNCT O
+FGF7 NOUN O
+, PUNCT O
+fibroblast NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+7 NUM I-LF
+; PUNCT O
+FGFR2 PROPN O
+, PUNCT O
+fibroblast NOUN O
+growth NOUN O
+factor NOUN O
+receptor NOUN O
+2 NUM O
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+HNF4α PROPN B-AC
+, PUNCT O
+hepatocyte NOUN B-LF
+nuclear ADJ I-LF
+factor NOUN I-LF
+4 NUM I-LF
+- PUNCT I-LF
+alpha NOUN I-LF
+; PUNCT O
+IRS2 NOUN O
+, PUNCT O
+insulin NOUN B-LF
+receptor NOUN I-LF
+substrate NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+Lenti PROPN B-AC
+- PUNCT B-AC
+mIrs2 PROPN B-AC
+, PUNCT O
+murine NOUN B-LF
+Irs2 PROPN I-LF
+transgene NOUN I-LF
+not PART I-LF
+targeted VERB I-LF
+by ADP I-LF
+human ADJ I-LF
+- PUNCT I-LF
+gene NOUN I-LF
+– PUNCT I-LF
+silencing VERB I-LF
+construct NOUN I-LF
+; PUNCT O
+mRNA NOUN B-AC
+, PUNCT O
+messenger NOUN B-LF
+RNA NOUN I-LF
+; PUNCT O
+pAPOA2 PROPN B-AC
+, PUNCT O
+human ADJ O
+APOA2 PROPN B-LF
+promoter NOUN I-LF
+; PUNCT O
+pIRS2 PROPN B-AC
+, PUNCT O
+IRS2 NOUN B-LF
+promoter NOUN I-LF
+; PUNCT O
+rFgf7 NOUN B-AC
+, PUNCT O
+recombinant ADJ B-LF
+Fgf7 NOUN I-LF
+; PUNCT O
+rhFGF7 PROPN B-AC
+, PUNCT O
+recombinant ADJ B-LF
+human ADJ I-LF
+FGF7 NOUN I-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+qPCR PROPN B-AC
+, PUNCT O
+reverse ADJ B-LF
+transcriptase NOUN I-LF
+- PUNCT I-LF
+quantitative ADJ I-LF
+PCR NOUN I-LF
+; PUNCT O
+RU PROPN B-AC
+, PUNCT O
+relative ADJ B-LF
+unit NOUN I-LF
+; PUNCT O
+sh NOUN O
+- PUNCT O
+IRS2 NOUN O
+, PUNCT O
+shRNA NOUN B-AC
+- PUNCT O
+targeting VERB O
+IRS2 NOUN O
+; PUNCT O
+sh NOUN B-AC
+- PUNCT B-AC
+luc NOUN B-AC
+, PUNCT O
+control NOUN B-LF
+luciferase NOUN I-LF
+; PUNCT O
+shRNA NOUN B-AC
+, PUNCT O
+short ADJ B-LF
+hairpin NOUN I-LF
+RNA NOUN I-LF
+; PUNCT O
+sh NOUN O
+- PUNCT O
+scram NOUN O
+, PUNCT O
+scrambled ADJ O
+shRNA NOUN B-AC
+. PUNCT O
+
+In ADP O
+segments NOUN O
+of ADP O
+the DET O
+thoracic ADJ O
+aorta NOUN O
+and CCONJ O
+femoral ADJ O
+artery NOUN O
+contracted VERB O
+with ADP O
+256 NUM O
+nM NOUN O
+endothelin-1 NOUN O
+, PUNCT O
+the DET O
+relaxing VERB O
+effects NOUN O
+of ADP O
+Ach PROPN B-AC
+were AUX O
+reversed VERB O
+by ADP O
+100 NUM O
+μM NOUN O
+L NOUN B-LF
+- PUNCT I-LF
+NG NOUN I-LF
+- PUNCT I-LF
+nitro NOUN I-LF
+arginine NOUN I-LF
+methyl NOUN I-LF
+ester NOUN I-LF
+( PUNCT O
+L NOUN B-AC
+- PUNCT B-AC
+NAME PROPN B-AC
+) PUNCT O
+( PUNCT O
+a DET O
+pharmacological ADJ O
+inhibitor NOUN O
+of ADP O
+NOSs PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+this PRON O
+did AUX O
+not PART O
+differ VERB O
+significantly ADV O
+between ADP O
+preparations NOUN O
+of ADP O
+KI PROPN B-AC
+and CCONJ O
+WT PROPN B-AC
+mice NOUN O
+( PUNCT O
+S5 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+Ontario PROPN O
+, PUNCT O
+it PRON O
+is AUX O
+mandatory ADJ O
+for ADP O
+all DET O
+long ADJ O
+- PUNCT O
+stay NOUN O
+home NOUN O
+care NOUN O
+clients NOUN O
+to PART O
+be AUX O
+assessed VERB O
+with ADP O
+a DET O
+comprehensive ADJ O
+clinical ADJ O
+assessment NOUN O
+tool NOUN O
+, PUNCT O
+the DET O
+Resident PROPN B-LF
+Assessment PROPN I-LF
+Instrument PROPN I-LF
+for ADP I-LF
+Home PROPN I-LF
+Care PROPN I-LF
+( PUNCT O
+RAI PROPN B-AC
+- PUNCT B-AC
+HC PROPN B-AC
+) PUNCT O
+, PUNCT O
+on ADP O
+a DET O
+semiannual ADJ O
+basis NOUN O
+. PUNCT O
+
+SCA3 PROPN B-AC
+is AUX O
+caused VERB O
+by ADP O
+an DET O
+unstable ADJ O
+cytosine NOUN B-LF
+- PUNCT I-LF
+adenine NOUN I-LF
+- PUNCT I-LF
+guanine NOUN I-LF
+( PUNCT O
+CAG PROPN B-AC
+) PUNCT O
+trinucleotide NOUN O
+expansion NOUN O
+mutation NOUN O
+in ADP O
+the DET O
+ATXN3 PROPN O
+gene NOUN O
+leading VERB O
+to ADP O
+an DET O
+expanded VERB O
+polyQ NOUN O
+tract NOUN O
+within ADP O
+the DET O
+ataxin-3 NOUN B-LF
+( PUNCT O
+ATX-3 PROPN B-AC
+) PUNCT O
+protein NOUN O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+Information NOUN O
+in ADP O
+the DET O
+OHIP PROPN B-AC
+Database PROPN O
+is AUX O
+recorded VERB O
+using VERB O
+physician NOUN O
+billing NOUN O
+claims NOUN O
+; PUNCT O
+information NOUN O
+in ADP O
+hospital NOUN O
+databases NOUN O
+is AUX O
+recorded VERB O
+using VERB O
+the DET O
+Canadian PROPN O
+Coding PROPN O
+Standards PROPN O
+for ADP O
+the DET O
+International PROPN B-LF
+Statistical PROPN I-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+and CCONJ I-LF
+Related PROPN I-LF
+Health PROPN I-LF
+Problems PROPN I-LF
+, PUNCT O
+10th ADJ O
+revision NOUN O
+( PUNCT O
+ICD-10 PROPN B-AC
+) PUNCT O
+or CCONJ O
+Diagnostic PROPN B-LF
+and CCONJ I-LF
+Statistical PROPN I-LF
+Manual PROPN I-LF
+of ADP I-LF
+Mental PROPN I-LF
+Disorders PROPN I-LF
+, PUNCT O
+4th ADJ O
+edition NOUN O
+( PUNCT O
+DSM PROPN B-AC
+- PUNCT O
+IV PROPN O
+) PUNCT O
+. PUNCT O
+The DET O
+information NOUN O
+in ADP O
+these DET O
+databases NOUN O
+has AUX O
+been AUX O
+shown VERB O
+to PART O
+be AUX O
+complete ADJ O
+and CCONJ O
+reliable ADJ O
+; PUNCT O
+sociodemographic ADJ O
+data NOUN O
+, PUNCT O
+physician NOUN O
+billing NOUN O
+claims NOUN O
+, PUNCT O
+and CCONJ O
+primary ADJ O
+diagnoses NOUN O
+in ADP O
+hospital NOUN O
+data NOUN O
+sets NOUN O
+have VERB O
+excellent ADJ O
+completeness NOUN O
+and CCONJ O
+accuracy NOUN O
+[ PUNCT O
+19 NUM O
+] PUNCT O
+. PUNCT O
+
+After ADP O
+collecting VERB O
+5ml NUM O
+of ADP O
+venous ADJ O
+blood NOUN O
+sample NOUN O
+in ADP O
+EDTA PROPN B-AC
+tube NOUN O
+from ADP O
+each DET O
+study NOUN O
+participants NOUN O
+, PUNCT O
+CBC PROPN O
+results NOUN O
+which PRON O
+include VERB O
+RBC NOUN O
+parameters NOUN O
+( PUNCT O
+RBC NOUN O
+count NOUN O
+, PUNCT O
+Hgb NOUN B-AC
+, PUNCT O
+mean ADJ B-LF
+cell NOUN I-LF
+hemoglobin NOUN I-LF
+( PUNCT O
+MCH PROPN B-AC
+) PUNCT O
+, PUNCT O
+mean ADJ B-LF
+cell NOUN I-LF
+hemoglobin NOUN I-LF
+concentration NOUN I-LF
+( PUNCT O
+MCHC PROPN B-AC
+) PUNCT O
+and CCONJ O
+mean ADJ B-LF
+cell NOUN I-LF
+volume NOUN I-LF
+( PUNCT O
+MCV PROPN B-AC
+) PUNCT O
+) PUNCT O
+, PUNCT O
+WBC NOUN O
+parameters NOUN O
+( PUNCT O
+WBC NOUN O
+count NOUN O
+, PUNCT O
+absolute ADJ O
+neutrophil NOUN O
+count NOUN O
+, PUNCT O
+neutrophil NOUN O
+percentage NOUN O
+, PUNCT O
+lymphocyte NOUN O
+count NOUN O
+, PUNCT O
+lymphocyte NOUN O
+percentage NOUN O
+, PUNCT O
+mixed ADJ O
+count NOUN O
+that PRON O
+encompasses VERB O
+eosinophil ADJ O
+, PUNCT O
+basophil ADJ O
+and CCONJ O
+monocyte NOUN O
+and CCONJ O
+mixed ADJ O
+cell NOUN O
+percentage NOUN O
+) PUNCT O
+and CCONJ O
+platelet NOUN O
+parameter NOUN O
+( PUNCT O
+platelet NOUN O
+count NOUN O
+and CCONJ O
+mean ADJ O
+platelet NOUN O
+volume NOUN O
+) PUNCT O
+were AUX O
+determined VERB O
+using VERB O
+sysmex PROPN O
+KX21 PROPN O
+hematology NOUN O
+analyzer NOUN O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+assisted ADJ B-LF
+reproductive ADJ I-LF
+technology NOUN I-LF
+; PUNCT O
+SC PROPN B-AC
+, PUNCT O
+spontaneous ADJ B-LF
+conception NOUN I-LF
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+IQR PROPN B-AC
+, PUNCT O
+interquartile ADJ B-LF
+range NOUN I-LF
+
+PPTs NOUN B-AC
+: PUNCT O
+pressure NOUN B-LF
+pain NOUN I-LF
+thresholds NOUN I-LF
+; PUNCT O
+TePs PROPN B-AC
+: PUNCT O
+tender NOUN B-LF
+points NOUN I-LF
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+explored VERB O
+the DET O
+role NOUN O
+of ADP O
+the DET O
+hypoxia NOUN B-LF
+- PUNCT I-LF
+inducible ADJ I-LF
+factors NOUN I-LF
+( PUNCT O
+HIFs NOUN B-AC
+) PUNCT O
+, PUNCT O
+HIF-1α NOUN B-AC
+( PUNCT O
+encoded VERB O
+by ADP O
+HIF1A PROPN O
+) PUNCT O
+and CCONJ O
+HIF-2α NOUN B-AC
+( PUNCT O
+encoded VERB O
+by ADP O
+EPAS1 PROPN O
+) PUNCT O
+. PUNCT O
+
+SA NOUN B-AC
+: PUNCT O
+suture NOUN B-LF
+anchor NOUN I-LF
+, PUNCT O
+TS NOUN B-AC
+: PUNCT O
+transosseous ADJ B-LF
+suture NOUN I-LF
+, PUNCT O
+QTR NOUN B-AC
+: PUNCT O
+quadriceps NOUN B-LF
+tendon NOUN I-LF
+rupture NOUN I-LF
+. PUNCT O
+
+Compared VERB O
+to PART O
+baseline NOUN O
+, NOUN O
+women NOUN O
+whose DET O
+most ADV O
+recent ADJ O
+pregnancy NOUN O
+occurred VERB O
+during ADP O
+the DET O
+implementation NOUN O
+period NOUN O
+were AUX O
+substantially ADV O
+more ADV O
+likely ADJ O
+to PART O
+receive VERB O
+antenatal ADJ O
+care NOUN O
+( PUNCT O
+71.8 NUM O
+% NOUN O
+versus ADP O
+39.3 NUM O
+% NOUN O
+, NOUN O
+prevalence NOUN B-LF
+rate NOUN I-LF
+ratio NOUN I-LF
+[ PUNCT O
+PRR NOUN B-AC
+] PUNCT O
+= X O
+1.83 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+1.64–2.04 NUM O
+] PUNCT O
+) PUNCT O
+and CCONJ O
+specific ADJ O
+interventions NOUN O
+such ADJ O
+as ADP O
+urine NOUN O
+testing NOUN O
+( PUNCT O
+42.4 NUM O
+% NOUN O
+versus ADP O
+15.7 NUM O
+% NOUN O
+, NOUN O
+PRR NOUN B-AC
+= X O
+2.69 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+2.69–3.54 NUM O
+] PUNCT O
+) PUNCT O
+, NOUN O
+malaria NOUN O
+screening NOUN O
+( PUNCT O
+55.9 NUM O
+% NOUN O
+versus ADP O
+21.9 NUM O
+% NOUN O
+, NOUN O
+PRR NOUN B-AC
+= X O
+2.88 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+2.15–3.85 NUM O
+] PUNCT O
+) PUNCT O
+, NOUN O
+and CCONJ O
+deworming NOUN O
+( PUNCT O
+58.2 NUM O
+% NOUN O
+versus ADP O
+4.1 NUM O
+% NOUN O
+, NOUN O
+PRR NOUN B-AC
+= X O
+14.18 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+10.76–18.71 NUM O
+] PUNCT O
+. PUNCT O
+
+One NUM O
+of ADP O
+the DET O
+best ADJ O
+surrogates NOUN O
+of ADP O
+chronic ADJ O
+inflammation NOUN O
+in ADP O
+the DET O
+pathogenesis NOUN O
+of ADP O
+tumor NOUN O
+is AUX O
+interleukin-6 NOUN B-LF
+( PUNCT O
+IL-6 PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+pleiotropic ADJ O
+inflammatory ADJ O
+cytokine NOUN O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+All DET O
+reconstructed VERB O
+sequences NOUN O
+were AUX O
+also ADV O
+subjected VERB O
+to ADP O
+an DET O
+alignment NOUN O
+- PUNCT O
+free ADJ O
+approach NOUN O
+using VERB O
+feature NOUN B-LF
+frequency NOUN I-LF
+profiling NOUN I-LF
+( PUNCT O
+FFP PROPN B-AC
+) PUNCT O
+[ X O
+53 NUM O
+] PUNCT O
+. PUNCT O
+
+Clinical ADJ O
+outcomes NOUN O
+were AUX O
+defined VERB O
+as ADP O
+rates NOUN O
+of ADP O
+admission NOUN O
+to ADP O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+( PUNCT O
+ICU PROPN B-AC
+) PUNCT O
+and CCONJ O
+in ADP O
+- PUNCT O
+hospital NOUN O
+mortality NOUN O
+and CCONJ O
+were AUX O
+monitored VERB O
+until ADP O
+the DET O
+10th ADJ O
+June PROPN O
+2020 NUM O
+. PUNCT O
+
+Apoptosis NOUN O
+of ADP O
+both PRON O
+, PUNCT O
+mitoNEET NOUN O
+- PUNCT O
+KD PROPN B-AC
+and CCONJ O
+control NOUN O
+cells NOUN O
+was AUX O
+diminished VERB O
+to ADP O
+comparable ADJ O
+levels NOUN O
+by ADP O
+using VERB O
+the DET O
+antioxidants NOUN O
+Tiron PROPN O
+and CCONJ O
+glutathione NOUN B-LF
+compound NOUN I-LF
+glutathione NOUN I-LF
+reduced VERB I-LF
+ethyl NOUN I-LF
+ester NOUN I-LF
+( PUNCT O
+GSH NOUN B-AC
+- PUNCT B-AC
+MEE PROPN B-AC
+) PUNCT O
+, PUNCT O
+indicating VERB O
+that SCONJ O
+mitoNEET NOUN O
+- PUNCT O
+dependent ADJ O
+apoptosis NOUN O
+is AUX O
+mediated VERB O
+by ADP O
+oxidative ADJ O
+stress NOUN O
+. PUNCT O
+
+A DET O
+milestone NOUN O
+meta NOUN O
+- NOUN O
+analysis NOUN O
+[ X O
+11 X O
+] X O
+mentioned VERB O
+the DET O
+independent ADJ O
+predictors NOUN O
+of ADP O
+CIN PROPN B-AC
+included VERB O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CKD PROPN B-AC
+) PUNCT O
+, PUNCT O
+CKD PROPN B-AC
+with ADP O
+DM PROPN B-AC
+, PUNCT O
+and CCONJ O
+use NOUN O
+of ADP O
+LOCM PROPN B-AC
+. PUNCT O
+However ADV O
+, PUNCT O
+CKD PROPN B-AC
+with ADP O
+DM PROPN B-AC
+group NOUN O
+had VERB O
+a DET O
+much ADV O
+higher ADJ O
+increase NOUN O
+of ADP O
+maximum ADJ O
+serum NOUN B-LF
+creatinine NOUN I-LF
+( PUNCT O
+SCr NOUN B-AC
+) PUNCT O
+, PUNCT O
+than ADP O
+CKD PROPN B-AC
+without ADP O
+DM PROPN B-AC
+after ADP O
+contrast NOUN O
+exposure NOUN O
+. PUNCT O
+
+The DET O
+mRNA NOUN O
+expression NOUN O
+of ADP O
+the DET O
+collagen NOUN B-LF
+I NUM I-LF
+, PUNCT O
+collagen NOUN O
+III NUM O
+and CCONJ O
+collagen NOUN O
+VI NUM O
+genes NOUN O
+was AUX O
+higher ADJ O
+in ADP O
+the DET O
+diaphragm NOUN O
+fibrogenic ADJ O
+cells NOUN O
+than ADP O
+in ADP O
+the DET O
+quadriceps NOUN O
+fibrogenic ADJ O
+cells NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+mRNA NOUN O
+expression NOUN O
+of ADP O
+the DET O
+fibronectin NOUN O
+gene NOUN O
+was AUX O
+similar ADJ O
+( PUNCT O
+Fig PROPN O
+4C NUM O
+) PUNCT O
+. PUNCT O
+Therefore ADV O
+, PUNCT O
+consistent ADJ O
+with ADP O
+more ADV O
+severe ADJ O
+fibrosis NOUN O
+in ADP O
+the DET O
+ColI PROPN B-AC
+- PROPN O
+GFP PROPN O
+/ SYM O
+mdx5cv NOUN O
+diaphragm NOUN O
+, PUNCT O
+the DET O
+ColI PROPN B-AC
+- PROPN O
+GFP PROPN O
+/ SYM O
+mdx5cv NOUN O
+diaphragm NOUN O
+fibrogenic ADJ O
+cells NOUN O
+exert VERB O
+a DET O
+higher ADJ O
+fibrogenic ADJ O
+function NOUN O
+than ADP O
+the DET O
+quadriceps NOUN O
+fibrogenic ADJ O
+cells NOUN O
+despite SCONJ O
+a DET O
+low ADJ O
+level NOUN O
+of ADP O
+α PROPN B-AC
+- PROPN B-AC
+SMA PROPN B-AC
+expression NOUN O
+by ADP O
+the DET O
+diaphragm NOUN O
+fibrogenic ADJ O
+cells NOUN O
+. PUNCT O
+α PROPN B-AC
+- PROPN B-AC
+SMA PROPN B-AC
+is AUX O
+not PART O
+a DET O
+marker NOUN O
+for ADP O
+the DET O
+fibrogenic ADJ O
+function NOUN O
+of ADP O
+fibrogenic ADJ O
+cells NOUN O
+in ADP O
+dystrophic ADJ O
+muscles NOUN O
+. PUNCT O
+
+Mouse ADJ O
+IgG1 NOUN O
+was AUX O
+used VERB O
+as ADP O
+a DET O
+control NOUN O
+of ADP O
+anti NOUN O
+- PUNCT O
+erbB1 NOUN O
+. PUNCT O
+Human ADJ O
+fibroblasts NOUN O
+and CCONJ O
+human ADJ B-LF
+umbilical ADJ I-LF
+vein NOUN I-LF
+endothelial ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+HUVECs NOUN B-AC
+) PUNCT O
+were AUX O
+cultured VERB O
+in ADP O
+96 NUM O
+- PUNCT O
+well NOUN O
+plates NOUN O
+. PUNCT O
+
+Metabolomics NOUN O
+technologies NOUN O
+based VERB O
+on ADP O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+( PUNCT O
+MS PROPN B-AC
+) PUNCT O
+and CCONJ O
+nuclear ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+( PUNCT O
+NMR PROPN B-AC
+) PUNCT O
+have AUX O
+enabled VERB O
+the DET O
+systematic ADJ O
+quantification NOUN O
+of ADP O
+hundreds NOUN O
+of ADP O
+metabolites NOUN O
+( PUNCT O
+the DET O
+“ PUNCT O
+metabolome NOUN O
+” PUNCT O
+) PUNCT O
+from ADP O
+a DET O
+single ADJ O
+biological ADJ O
+sample NOUN O
+. PUNCT O
+
+Aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+AST PROPN B-AC
+) PUNCT O
+and CCONJ O
+alanine ADJ B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+activities NOUN O
+in ADP O
+plasma NOUN O
+were AUX O
+determined VERB O
+using VERB O
+corresponding ADJ O
+colorimetric ADJ O
+assay NOUN O
+kits NOUN O
+supplied VERB O
+by ADP O
+Sigma PROPN O
+- PUNCT O
+Aldrich PROPN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AFP PROPN B-AC
+, PUNCT O
+alpha NOUN B-LF
+- PUNCT I-LF
+fetoprotein NOUN I-LF
+; PUNCT O
+IQR PROPN O
+, PUNCT O
+interquartile ADJ O
+range NOUN O
+; PUNCT O
+PEIT PROPN O
+, PUNCT O
+percutaneous ADJ O
+ethanol NOUN O
+injection NOUN O
+therapy NOUN O
+; PUNCT O
+RFA PROPN O
+, PUNCT O
+radiofrequency ADJ O
+ablation NOUN O
+; PUNCT O
+RT PROPN O
+, PUNCT O
+radiotherapy NOUN O
+; PUNCT O
+TACE PROPN O
+, PUNCT O
+transarterial ADJ O
+chemoembolization NOUN O
+. PUNCT O
+
+Karyotype NOUN O
+and CCONJ O
+genome NOUN O
+- PUNCT O
+wide ADJ O
+copy NOUN B-LF
+number NOUN I-LF
+variation NOUN I-LF
+( PUNCT O
+CNV PROPN B-AC
+) PUNCT O
+analyses NOUN O
+demonstrated VERB O
+that PRON O
+genomic ADJ O
+integrity NOUN O
+was AUX O
+maintained VERB O
+in ADP O
+YAP−/− NOUN B-AC
+and CCONJ O
+TAZ−/− NOUN B-AC
+hESCs NOUN B-AC
+after ADP O
+more ADJ O
+than ADP O
+30 NUM O
+passages NOUN O
+( PUNCT O
+Figs NOUN O
+1F NOUN O
+and CCONJ O
+S1F NOUN O
+) PUNCT O
+. PUNCT O
+Moreover ADV O
+, PUNCT O
+YAP−/− NOUN B-AC
+and CCONJ O
+TAZ−/− NOUN B-AC
+hESCs NOUN B-AC
+displayed VERB O
+transcriptional ADJ O
+profiles NOUN O
+that PRON O
+were AUX O
+highly ADV O
+similar ADJ O
+to ADP O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT O
+WT PROPN B-AC
+) PUNCT O
+hESCs NOUN B-AC
+( PUNCT O
+Fig NOUN O
+1 NUM O
+G NOUN O
+) PUNCT O
+. PUNCT O
+
+HbA1c NOUN B-AC
+, PUNCT O
+hemoglobin NOUN B-LF
+A1c NOUN I-LF
+. PUNCT O
+
+Figures NOUN O
+for ADP O
+the DET O
+65 NUM O
++ NUM O
+-y NOUN O
+age NOUN O
+group NOUN O
+from ADP O
+2004/2005 NUM O
+onwards ADV O
+were AUX O
+taken VERB O
+from ADP O
+the DET O
+Health PROPN B-LF
+Protection PROPN I-LF
+Agency PROPN I-LF
+/ SYM I-LF
+Department PROPN I-LF
+of ADP I-LF
+Health PROPN I-LF
+( PUNCT O
+HPA PROPN B-AC
+/ SYM B-AC
+DH PROPN B-AC
+) PUNCT O
+annual ADJ O
+reports NOUN O
+on ADP O
+the DET O
+influenza NOUN O
+programme NOUN O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+Then ADV O
+, PUNCT O
+heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+HR NOUN B-AC
+) PUNCT O
+, PUNCT O
+systolic ADJ O
+arterial ADJ O
+pressure NOUN O
+( PUNCT O
+SAP PROPN B-AC
+) PUNCT O
+, PUNCT O
+diastolic ADJ B-LF
+arterial ADJ I-LF
+pressure NOUN I-LF
+( PUNCT O
+DAP PROPN B-AC
+) PUNCT O
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+systolic ADJ I-LF
+pressure NOUN I-LF
+( PUNCT O
+LVSP PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+left ADJ B-LF
+ventricular ADJ I-LF
+end NOUN I-LF
+- NOUN I-LF
+diastolic ADJ I-LF
+pressure NOUN I-LF
+( PUNCT O
+LVEDP PROPN B-AC
+) PUNCT O
+were AUX O
+recorded VERB O
+using VERB O
+an DET O
+Ultra PROPN O
+- NOUN O
+Miniature PROPN O
+Pressure PROPN O
+Catheter PROPN O
+( PUNCT O
+Scisense PROPN O
+advancing VERB O
+micro NOUN O
+- NOUN O
+sensor NOUN O
+technology NOUN O
+™ PUNCT O
+, PUNCT O
+USA PROPN O
+/ SYM O
+CAN PROPN O
+) PUNCT O
+under ADP O
+mild ADJ O
+anaesthesia NOUN O
+( PUNCT O
+1 NUM O
+% NOUN O
+isoflurane NOUN O
+, PUNCT O
+heart NOUN B-LF
+rate NOUN I-LF
+: PUNCT O
+~500 NUM O
+min–1 NOUN O
+) PUNCT O
+. PUNCT O
+
+PSO NOUN B-AC
+: PUNCT O
+post NOUN B-LF
+- PUNCT I-LF
+outlier NOUN I-LF
+; PUNCT O
+N NOUN O
+: PUNCT O
+number NOUN O
+of ADP O
+included VERB O
+studies NOUN O
+; PUNCT O
+n NOUN O
+: PUNCT O
+sample NOUN O
+size NOUN O
+; PUNCT O
+Pc NOUN B-AC
+: PUNCT O
+Bonferroni NOUN O
+- PUNCT O
+corrected VERB O
+P NOUN O
+- PUNCT O
+value NOUN O
+; PUNCT O
+Pci NOUN B-AC
+: PUNCT O
+Bonferroni NOUN B-LF
+- PUNCT I-LF
+corrected VERB I-LF
+P NOUN I-LF
+- PUNCT I-LF
+value NOUN I-LF
+for ADP I-LF
+interaction NOUN I-LF
+; PUNCT O
+OR NOUN B-AC
+: PUNCT O
+odd ADJ O
+ratio NOUN O
+; PUNCT O
+CI NOUN B-AC
+: PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+
+MSC PROPN B-AC
+, PUNCT O
+multi ADJ B-LF
+- ADJ I-LF
+tRNA ADJ I-LF
+synthetase NOUN I-LF
+complex NOUN I-LF
+. PUNCT O
+
+The DET O
+objective NOUN O
+of ADP O
+this DET O
+study NOUN O
+was AUX O
+to PART O
+assess VERB O
+the DET O
+classification NOUN O
+capability NOUN O
+of ADP O
+Breast PROPN B-LF
+Imaging PROPN I-LF
+Reporting PROPN I-LF
+and CCONJ I-LF
+Data PROPN I-LF
+System PROPN I-LF
+( PUNCT O
+BI PROPN B-AC
+- PUNCT B-AC
+RADS PROPN B-AC
+) PUNCT O
+ultrasound NOUN O
+feature NOUN O
+descriptors NOUN O
+targeting VERB O
+established VERB O
+commercial ADJ O
+transcriptomic ADJ O
+gene NOUN O
+signatures NOUN O
+that PRON O
+guide VERB O
+management NOUN O
+of ADP O
+breast NOUN O
+cancer NOUN O
+. PUNCT O
+
+These DET O
+findings NOUN O
+support VERB O
+the DET O
+current ADJ O
+World PROPN O
+Health PROPN O
+Organization/ PROPN O
+United PROPN B-LF
+Nations PROPN I-LF
+Children PROPN I-LF
+'s PART I-LF
+Emergency PROPN I-LF
+Fund PROPN I-LF
+( PUNCT O
+UNICEF PROPN B-AC
+) PUNCT O
+system NOUN O
+that PRON O
+categorizes VERB O
+shared ADJ O
+sanitation NOUN O
+as ADP O
+unimproved ADJ O
+. PUNCT O
+
+Prior ADV O
+to ADP O
+stimulation NOUN O
+, PUNCT O
+cells NOUN O
+were AUX O
+washed VERB O
+once ADV O
+with ADP O
+phosphate NOUN B-LF
+- PUNCT I-LF
+buffered VERB I-LF
+saline NOUN I-LF
+( PUNCT O
+PBS PROPN B-AC
+) PUNCT O
+and CCONJ O
+incubated VERB O
+for ADP O
+the DET O
+indicated VERB O
+time NOUN O
+periods NOUN O
+in ADP O
+cell NOUN O
+culture NOUN O
+medium NOUN O
+containing VERB O
+the DET O
+different ADJ O
+agents NOUN O
+at ADP O
+the DET O
+indicated VERB O
+concentrations NOUN O
+. PUNCT O
+
+Body NOUN O
+composition NOUN O
+also ADV O
+differed VERB O
+, PUNCT O
+with ADP O
+dual ADJ B-LF
+- NOUN I-LF
+energy NOUN I-LF
+X NOUN I-LF
+- NOUN I-LF
+ray NOUN I-LF
+absorptiometry NOUN I-LF
+( PUNCT O
+DEXA PROPN B-AC
+) PUNCT O
+scans NOUN O
+showing VERB O
+a DET O
+higher ADJ O
+percent NOUN O
+of ADP O
+body NOUN O
+fat NOUN O
+in ADP O
+Oct1-/- NOUN O
+compared VERB O
+to ADP O
+Oct1+/+ NOUN O
+mice NOUN O
+( PUNCT O
+p NOUN O
+= SYM O
+0.001 NUM O
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+2C NUM O
+) PUNCT O
+. PUNCT O
+Consistent ADJ O
+with ADP O
+the DET O
+greater ADJ O
+proportion NOUN O
+of ADP O
+body NOUN O
+fat NOUN O
+, PUNCT O
+Oct1-/- NOUN O
+mice NOUN O
+had VERB O
+greater ADJ O
+epididymal ADJ O
+fat NOUN O
+pad NOUN O
+weights NOUN O
+and CCONJ O
+reduced VERB O
+liver NOUN O
+weight NOUN O
+compared VERB O
+to ADP O
+Oct1+/+ NOUN O
+mice NOUN O
+( PUNCT O
+p NOUN O
+< SYM O
+0.0001 NUM O
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+2D NUM O
+and CCONJ O
+S2E PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+Stigma NOUN O
+and CCONJ O
+high ADJ O
+- PUNCT O
+care NOUN O
+needs NOUN O
+can AUX O
+present VERB O
+barriers NOUN O
+to ADP O
+the DET O
+provision NOUN O
+of ADP O
+high ADJ O
+- PUNCT O
+quality NOUN O
+primary ADJ O
+care NOUN O
+for ADP O
+people NOUN O
+with ADP O
+opioid NOUN B-LF
+use NOUN I-LF
+disorder NOUN I-LF
+( PUNCT O
+OUD PROPN B-AC
+) PUNCT O
+and CCONJ O
+those PRON O
+prescribed VERB O
+opioids NOUN O
+for ADP O
+chronic ADJ O
+pain NOUN O
+. PUNCT O
+
+The DET O
+prevalence NOUN O
+of ADP O
+obesity NOUN O
+, PUNCT O
+the DET O
+strongest ADJ O
+known VERB O
+risk NOUN O
+factor NOUN O
+for ADP O
+type NOUN O
+2 NUM O
+diabetes NOUN O
+, PUNCT O
+has AUX O
+increased VERB O
+across ADP O
+the DET O
+world NOUN O
+, PUNCT O
+and CCONJ O
+more ADV O
+so ADV O
+in ADP O
+African ADJ O
+women NOUN O
+, PUNCT O
+with ADP O
+a DET O
+recent ADJ O
+meta NOUN O
+- NOUN O
+analysis NOUN O
+showing VERB O
+that SCONJ O
+in ADP O
+this DET O
+group NOUN O
+, PUNCT O
+mean ADJ O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+increased VERB O
+from ADP O
+22 NUM O
+kg NOUN O
+/ SYM O
+m2 NUM O
+in ADP O
+1980 NUM O
+to ADP O
+25 NUM O
+kg NOUN O
+/ SYM O
+m2 NUM O
+in ADP O
+2014 NUM O
+[ PUNCT O
+3 NUM O
+] PUNCT O
+. PUNCT O
+
+MALDI PROPN B-AC
+- PUNCT B-AC
+TOF PROPN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+, PUNCT O
+matrix NOUN B-LF
+- PUNCT I-LF
+assisted VERB I-LF
+laser NOUN I-LF
+desorption NOUN I-LF
+/ SYM I-LF
+ionization NOUN I-LF
+time NOUN I-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+flight NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+; PUNCT O
+mamA NOUN B-AC
+, PUNCT O
+methylarginine NOUN B-LF
+modification NOUN I-LF
+; PUNCT O
+mcmA NOUN B-AC
+, PUNCT O
+methylcysteine NOUN B-LF
+modification NOUN I-LF
+; PUNCT O
+MCR PROPN B-AC
+, PUNCT O
+methyl NOUN B-LF
+- PUNCT I-LF
+coenzyme NOUN I-LF
+M PROPN I-LF
+reductase NOUN I-LF
+; PUNCT O
+McrA PROPN B-AC
+, PUNCT O
+alpha NOUN B-LF
+subunit NOUN I-LF
+of ADP I-LF
+MCR PROPN I-LF
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+NA NOUN O
+, PUNCT O
+not PART O
+available ADJ O
+. PUNCT O
+
+( PUNCT O
+a X O
+) PUNCT O
+66 NUM O
+propensity NOUN O
+score NOUN O
+- PUNCT O
+matched VERB O
+patients NOUN O
+in ADP O
+each PRON O
+of ADP O
+peg NOUN O
+- PUNCT O
+interferon NOUN B-LF
+and CCONJ O
+ribavirin NOUN O
+( PUNCT O
+PEG PROPN B-AC
+- PUNCT B-AC
+IFN PROPN B-AC
+/ SYM B-AC
+RBV PROPN B-AC
+) PUNCT O
+and CCONJ O
+daclatasvir NOUN B-LF
+plus CCONJ I-LF
+asunaprevir NOUN I-LF
+( PUNCT O
+DCV PROPN B-AC
+/ SYM B-AC
+ASV PROPN B-AC
+) PUNCT O
+groups NOUN O
+were AUX O
+analyzed VERB O
+. PUNCT O
+( PUNCT O
+b X O
+) PUNCT O
+Patients NOUN O
+were AUX O
+grouped VERB O
+by ADP O
+FIB4 PROPN O
+index NOUN O
+. PUNCT O
+
+Data NOUN O
+denote VERB O
+mean ADJ O
+± ADJ O
+SEM NOUN O
+, PUNCT O
+Student NOUN O
+t NOUN O
+test NOUN O
+( PUNCT O
+D NOUN O
+, PUNCT O
+F NOUN O
+) PUNCT O
+, PUNCT O
+* PUNCT O
+p NOUN O
+< ADP O
+0.05 NUM O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< ADP O
+0.001 NUM O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< ADP O
+0.0001 NUM O
+. PUNCT O
+a.u NOUN O
+. PUNCT O
+, PUNCT O
+arbitrary ADJ O
+unit NOUN O
+; PUNCT O
+AZ PROPN B-AC
+, PUNCT O
+active ADJ B-LF
+zone NOUN I-LF
+; PUNCT O
+Brp PROPN B-AC
+, PUNCT O
+Bruchpilot NOUN B-LF
+; PUNCT O
+cpx PROPN B-AC
+, PUNCT O
+complexin NOUN B-LF
+; PUNCT O
+Ctrl PROPN B-AC
+, PUNCT O
+control NOUN B-LF
+; PUNCT O
+eEJC PROPN B-AC
+, PUNCT O
+evoked VERB B-LF
+EJC PROPN I-LF
+; PUNCT O
+EJC PROPN B-AC
+, PUNCT O
+excitatory ADJ B-LF
+junction NOUN I-LF
+current NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+HEK PROPN O
+, PUNCT O
+human ADJ O
+embryonic ADJ O
+kidney NOUN O
+; PUNCT O
+HRP PROPN B-AC
+, PUNCT O
+horseradish NOUN B-LF
+peroxidase NOUN I-LF
+; PUNCT O
+mEJC PROPN B-AC
+, PUNCT O
+miniature ADJ B-LF
+EJC PROPN I-LF
+; PUNCT O
+NMJ PROPN B-AC
+, PUNCT O
+neuromuscular ADJ B-LF
+junction NOUN I-LF
+; PUNCT O
+NO PROPN B-AC
+, PUNCT O
+nitric NOUN B-LF
+oxide NOUN I-LF
+; PUNCT O
+PLA PROPN B-AC
+, PUNCT O
+proximity NOUN B-LF
+ligation NOUN I-LF
+assay NOUN I-LF
+; PUNCT O
+QC PROPN B-AC
+, PUNCT O
+quantal ADJ B-LF
+content NOUN I-LF
+; PUNCT O
+STED PROPN B-AC
+, PUNCT O
+stimulated ADJ B-LF
+emission NOUN I-LF
+depletion NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Interestingly ADV O
+, PUNCT O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+, PUNCT O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+AST PROPN B-AC
+) PUNCT O
+, PUNCT O
+bilirubin NOUN O
+, PUNCT O
+total ADJ B-LF
+cholesterol NOUN I-LF
+( PUNCT O
+TC PROPN B-AC
+) PUNCT O
+and CCONJ O
+triglyceride NOUN B-LF
+( PUNCT O
+TG NOUN B-AC
+) PUNCT O
+profiles NOUN O
+confirms VERB O
+USG PROPN B-AC
+images NOUN O
+of ADP O
+overweight ADJ O
+, PUNCT O
+obese ADJ O
+patients NOUN O
+. PUNCT O
+
+ANC PROPN B-AC
+, PUNCT O
+anteriormost NOUN B-LF
+NC PROPN I-LF
+; PUNCT O
+Ecad PROPN B-AC
+, PUNCT O
+Ecadherin NOUN B-LF
+; PUNCT O
+ERC PROPN B-AC
+, PUNCT O
+entrance NOUN B-LF
+RC PROPN I-LF
+; PUNCT O
+ES9 PROPN B-AC
+, PUNCT O
+early ADJ B-LF
+S9 NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+LS9 PROPN B-AC
+, PUNCT O
+late ADJ B-LF
+S9 NOUN I-LF
+; PUNCT O
+MS9 PROPN B-AC
+, PUNCT O
+mid ADJ B-LF
+S9 NOUN I-LF
+; PUNCT O
+NC PROPN B-AC
+, PUNCT O
+nurse NOUN B-LF
+cell NOUN I-LF
+; PUNCT O
+Oo PROPN O
+, PUNCT O
+oocyte NOUN O
+; PUNCT O
+PNC PROPN B-AC
+, PUNCT O
+posteriormost NOUN B-LF
+NC PROPN I-LF
+; PUNCT O
+RC PROPN B-AC
+, PUNCT O
+ring NOUN B-LF
+canal NOUN I-LF
+; PUNCT O
+S PROPN O
+, PUNCT O
+stage NOUN O
+. PUNCT O
+
+Based VERB O
+on ADP O
+the DET O
+HTS PROPN B-AC
+data NOUN O
+from ADP O
+the DET O
+Argonaute PROPN B-LF
+( PUNCT O
+AGO)-associated PROPN B-AC
+sRNAs NOUN B-AC
+, PUNCT O
+many ADJ O
+Pol PROPN B-AC
+IV- PROPN O
+, PUNCT O
+RDR- PROPN B-AC
+and CCONJ O
+DCL PROPN B-AC
+- PUNCT O
+dependent ADJ O
+PASRs NOUN B-AC
+and CCONJ O
+TASRs NOUN B-AC
+were AUX O
+preferentially ADV O
+loaded VERB O
+into ADP O
+AGO4 PROPN O
+silencing VERB O
+complexes NOUN O
+. PUNCT O
+
+We PRON O
+aimed VERB O
+to PART O
+develop VERB O
+and CCONJ O
+validate VERB O
+vital ADJ O
+sign NOUN O
+based VERB O
+Manchester PROPN B-LF
+Triage PROPN I-LF
+System PROPN I-LF
+( PUNCT O
+MTS PROPN B-AC
+) PUNCT O
+discriminators NOUN O
+to PART O
+improve VERB O
+triage NOUN O
+of ADP O
+children NOUN O
+at ADP O
+the DET O
+emergency NOUN O
+department NOUN O
+. PUNCT O
+
+AA PROPN B-AC
+, PUNCT O
+aortic ADJ B-LF
+arch NOUN I-LF
+; PUNCT O
+dpf PROPN B-AC
+, PUNCT O
+days NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+IF PROPN B-AC
+, PUNCT O
+mmunofluorescence NOUN O
+; PUNCT O
+kdrl PROPN B-AC
+, PUNCT O
+kinase NOUN B-LF
+insert NOUN I-LF
+domain NOUN I-LF
+receptor NOUN I-LF
+like ADP I-LF
+. PUNCT O
+
+To PART O
+further ADV O
+test VERB O
+whether SCONJ O
+directional ADJ O
+migration NOUN O
+of ADP O
+antigen NOUN O
+- VERB O
+engaged VERB O
+B NOUN O
+cells NOUN O
+to ADP O
+the DET O
+B NOUN B-AC
+/ SYM B-AC
+T NOUN B-AC
+boundary NOUN O
+occurred VERB O
+in ADP O
+response NOUN O
+to ADP O
+a DET O
+CCR7 PROPN O
+ligand NOUN O
+gradient NOUN O
+, PUNCT O
+we PRON O
+tracked VERB O
+the DET O
+migration NOUN O
+of ADP O
+carboxyfluorescein NOUN B-LF
+diacetate NOUN I-LF
+succinimidyl NOUN I-LF
+ester NOUN I-LF
+( PUNCT O
+CFSE)–labeled VERB B-AC
+CCR7−/− NOUN O
+Ig NOUN B-AC
+- VERB B-AC
+tg NOUN B-AC
+B NOUN O
+cells NOUN O
+in ADP O
+wild ADJ O
+- VERB O
+type NOUN O
+recipients NOUN O
+1–4 NUM O
+h NOUN O
+after ADP O
+antigen NOUN O
+exposure NOUN O
+. PUNCT O
+5-(and-6)-(((4 NUM B-LF
+- VERB I-LF
+chloromethyl)benzoyl)amino)tetramethylrhodamine NOUN I-LF
+( PUNCT O
+CMTMR)–labeled NOUN B-AC
+CCR7+/+ NOUN O
+Ig NOUN B-AC
+- VERB B-AC
+tg NOUN B-AC
+B NOUN O
+cells NOUN O
+were AUX O
+co VERB O
+- VERB O
+transferred VERB O
+with ADP O
+the DET O
+CCR7−/− NOUN O
+cells NOUN O
+as ADP O
+an DET O
+internal ADJ O
+control NOUN O
+. PUNCT O
+
+The DET O
+malaria NOUN O
+genome NOUN O
+sequencing NOUN O
+consortium NOUN O
+estimates VERB O
+that SCONJ O
+more ADJ O
+than ADP O
+60 NUM O
+% NOUN O
+of ADP O
+the DET O
+5,409 NUM O
+predicted VERB O
+open ADJ B-LF
+reading NOUN I-LF
+frames NOUN I-LF
+( PUNCT O
+ORFs PROPN B-AC
+) PUNCT O
+lack VERB O
+sequence NOUN O
+similarity NOUN O
+to ADP O
+genes NOUN O
+from ADP O
+any DET O
+other ADJ O
+known VERB O
+organism NOUN O
+( PUNCT O
+Gardner PROPN O
+et CCONJ O
+al X O
+. PUNCT O
+2002 NUM O
+) PUNCT O
+. PUNCT O
+
+All DET O
+continuous ADJ O
+social ADJ O
+determinant ADJ O
+exposure NOUN O
+variables NOUN O
+were AUX O
+standardized VERB O
+to PART O
+a DET O
+1 NUM O
+– PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT O
+SD NOUN B-AC
+) PUNCT O
+change NOUN O
+to PART O
+allow VERB O
+for ADP O
+direct ADJ O
+comparisons NOUN O
+of ADP O
+effect NOUN O
+sizes NOUN O
+across ADP O
+social ADJ O
+determinants NOUN O
+. PUNCT O
+
+Furthermore ADV O
+, PUNCT O
+MAX2 PROPN B-AC
+directly ADV O
+interacts VERB O
+with ADP O
+the DET O
+BR PROPN B-AC
+transcriptional ADJ O
+effector NOUN O
+bri1 PROPN B-LF
+- PUNCT I-LF
+EMS PROPN I-LF
+- PUNCT I-LF
+SUPPRESSOR PROPN I-LF
+1 NUM I-LF
+( PUNCT O
+BES1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+leading VERB O
+to ADP O
+accelerated VERB O
+BES1 PROPN B-AC
+degradation NOUN O
+[ PUNCT O
+33 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+predicted VERB O
+that SCONJ O
+novelty NOUN O
+would AUX O
+lead VERB O
+to ADP O
+a DET O
+learning NOUN O
+- PUNCT O
+independent ADJ O
+increase NOUN O
+in ADP O
+immediate ADJ B-LF
+early ADJ I-LF
+gene NOUN I-LF
+( PUNCT O
+IEG PROPN B-AC
+) PUNCT O
+mRNA NOUN O
+expression NOUN O
+in ADP O
+the DET O
+hippocampus NOUN O
+related VERB O
+to ADP O
+the DET O
+production NOUN O
+of ADP O
+plasticity NOUN O
+- PUNCT O
+related VERB O
+proteins NOUN O
+implicated VERB O
+in ADP O
+synaptic ADJ O
+tagging NOUN O
+and CCONJ O
+capture NOUN O
+[ X O
+32 NUM O
+] PUNCT O
+and CCONJ O
+the DET O
+consequent ADJ O
+consolidation NOUN O
+of ADP O
+hippocampal ADJ O
+traces NOUN O
+[ X O
+29 NUM O
+] PUNCT O
+. PUNCT O
+
+ACKR PROPN B-AC
+, PUNCT O
+atypical ADJ B-LF
+chemokine NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+E PROPN O
+, PUNCT O
+embryonic ADJ O
+day NOUN O
+; PUNCT O
+FSC PROPN O
+, PUNCT O
+forward ADJ O
+scatter NOUN O
+; PUNCT O
+SSC PROPN O
+, PUNCT O
+side NOUN O
+scatter NOUN O
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+type NOUN I-LF
+; PUNCT O
+YS PROPN B-AC
+, PUNCT O
+yolk NOUN B-LF
+sac NOUN I-LF
+. PUNCT O
+
+Nitrogen NOUN O
+- PUNCT O
+fixing VERB O
+root NOUN B-LF
+nodule NOUN I-LF
+symbiosis NOUN I-LF
+( PUNCT O
+RNS NOUN B-AC
+) PUNCT O
+occurs VERB O
+in ADP O
+two NUM O
+major ADJ O
+forms NOUN O
+. PUNCT O
+
+Lung NOUN B-LF
+adenocarcinoma NOUN I-LF
+( PUNCT O
+LUAD PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+main ADJ O
+subtype NOUN O
+of ADP O
+NSCLC PROPN B-AC
+, PUNCT O
+accounts VERB O
+for ADP O
+approximately ADV O
+40 NUM O
+% NOUN O
+of ADP O
+lung NOUN O
+cancer NOUN O
+patients NOUN O
+. PUNCT O
+
+The DET O
+oldest ADJ O
+cholinergic ADJ O
+hypothesis NOUN O
+is AUX O
+used VERB O
+to PART O
+elevate VERB O
+the DET O
+level NOUN O
+of ADP O
+cognitive ADJ O
+impairment NOUN O
+and CCONJ O
+acetylcholinesterase NOUN B-LF
+( PUNCT O
+AChE PROPN B-AC
+) PUNCT O
+comprises VERB O
+the DET O
+major ADJ O
+targeted VERB O
+enzyme NOUN O
+in ADP O
+AD PROPN B-AC
+. PUNCT O
+Thus ADV O
+, PUNCT O
+acetylcholinesterase NOUN B-LF
+inhibitors NOUN I-LF
+( PUNCT O
+AChEI PROPN B-AC
+) PUNCT O
+constitutes VERB O
+the DET O
+essential ADJ O
+remedy NOUN O
+for ADP O
+the DET O
+treatment NOUN O
+of ADP O
+AD PROPN B-AC
+. PUNCT O
+The DET O
+study NOUN O
+aims VERB O
+to PART O
+evaluate VERB O
+the DET O
+interactions NOUN O
+between ADP O
+natural ADJ O
+molecules NOUN O
+and CCONJ O
+AChE PROPN B-AC
+by ADP O
+Surface PROPN B-LF
+Plasmon PROPN I-LF
+Resonance PROPN I-LF
+( PUNCT O
+SPR PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+molecules NOUN O
+like ADP O
+alkaloids NOUN O
+, PUNCT O
+polyphenols NOUN O
+and CCONJ O
+substrates NOUN O
+of ADP O
+AChE PROPN B-AC
+have AUX O
+been AUX O
+considered VERB O
+for ADP O
+the DET O
+study NOUN O
+with ADP O
+a DET O
+major ADJ O
+emphasis NOUN O
+on ADP O
+affinity NOUN O
+and CCONJ O
+kinetics NOUN O
+. PUNCT O
+
+RIP PROPN B-AC
+TG PROPN B-AC
+and CCONJ O
+WT PROPN B-AC
+littermates NOUN O
+fed VERB O
+a DET O
+chow NOUN B-LF
+diet NOUN I-LF
+( PUNCT O
+CD PROPN B-AC
+) PUNCT O
+exhibited VERB O
+similar ADJ O
+body NOUN B-LF
+weight NOUN I-LF
+( PUNCT O
+BW NOUN B-AC
+) PUNCT O
+, PUNCT O
+glucose NOUN O
+tolerance NOUN O
+, PUNCT O
+insulin NOUN O
+sensitivity NOUN O
+, PUNCT O
+blood NOUN O
+glucose NOUN O
+, PUNCT O
+blood NOUN O
+insulin NOUN O
+, PUNCT O
+and CCONJ O
+tissue NOUN O
+morphology NOUN O
+( PUNCT O
+S3B NOUN O
+– SYM O
+S3H NOUN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+No PROPN O
+. PUNCT O
+Mfr PROPN O
+. PUNCT O
+: PUNCT O
+number NOUN O
+of ADP O
+manufactures NOUN O
+; PUNCT O
+DDD PROPN B-AC
+: PUNCT O
+Defined VERB B-LF
+daily ADJ I-LF
+dose NOUN I-LF
+. PUNCT O
+
+The DET O
+pellet NOUN O
+durability NOUN O
+was AUX O
+presented VERB O
+as ADP O
+a DET O
+Pellet PROPN B-LF
+Durability PROPN I-LF
+Index PROPN I-LF
+( PUNCT O
+PDI PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+was AUX O
+measured VERB O
+using VERB O
+the DET O
+“ PUNCT O
+Pfost PROPN O
+” PUNCT O
+method NOUN O
+and CCONJ O
+expressed VERB O
+on ADP O
+a DET O
+percentage NOUN O
+basis NOUN O
+[ PUNCT O
+29 NUM O
+] PUNCT O
+. PUNCT O
+
+CRL PROPN O
+, PUNCT O
+control NOUN O
+; PUNCT O
+IF1 NOUN B-AC
+, PUNCT O
+ATPase NOUN B-LF
+inhibitory ADJ I-LF
+factor NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+IF1KO PROPN B-AC
+, PUNCT O
+IF1 NOUN B-LF
+knockout NOUN I-LF
+; PUNCT O
+IF1TG PROPN B-AC
+, PUNCT O
+IF1 NOUN B-LF
+overexpressing ADJ I-LF
+transgenic ADJ I-LF
+. PUNCT O
+
+NMIBC PROPN B-AC
+is AUX O
+treated VERB O
+by ADP O
+transurethral ADJ B-LF
+resection NOUN I-LF
+of ADP I-LF
+the DET I-LF
+bladder NOUN I-LF
+tumor NOUN I-LF
+( PUNCT O
+TURBT PROPN B-AC
+) PUNCT O
+, PUNCT O
+followed VERB O
+by ADP O
+the DET O
+administration NOUN O
+of ADP O
+adjuvant ADJ O
+intravesical ADJ O
+treatment NOUN O
+with ADP O
+bacillus NOUN B-LF
+Calmette PROPN I-LF
+- PUNCT I-LF
+Guerin PROPN I-LF
+( PUNCT O
+BCG PROPN B-AC
+) PUNCT O
+or CCONJ O
+chemotherapeutic ADJ O
+agents NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+adriamycin NOUN B-LF
+( PUNCT O
+ADM PROPN B-AC
+) PUNCT O
+, PUNCT O
+mitomycin NOUN B-LF
+C PROPN I-LF
+( PUNCT O
+MMC PROPN B-AC
+) PUNCT O
+, PUNCT O
+gemcitabine NOUN B-LF
+( PUNCT O
+GEM PROPN B-AC
+) PUNCT O
+, PUNCT O
+or CCONJ O
+docetaxel NOUN B-LF
+( PUNCT O
+DTX PROPN B-AC
+) PUNCT O
+[ PUNCT O
+4 NUM O
+, PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+COVID-19 NOUN B-AC
+, PUNCT O
+coronavirus NOUN B-LF
+disease NOUN I-LF
+2019 NUM I-LF
+. PUNCT O
+
+The DET O
+HT15 PROPN O
+team NOUN O
+used VERB O
+brief ADJ O
+messages NOUN O
+delivered VERB O
+by ADP O
+short ADJ B-LF
+message NOUN I-LF
+service NOUN I-LF
+( PUNCT O
+SMS PROPN B-AC
+) PUNCT O
+to PART O
+provide VERB O
+study NOUN O
+participants NOUN O
+with ADP O
+post ADJ O
+- ADJ O
+clinic ADJ O
+visit NOUN O
+support NOUN O
+. PUNCT O
+
+The DET O
+recombinant ADJ O
+plasmids NOUN O
+were AUX O
+used VERB O
+as ADP O
+templates NOUN O
+for ADP O
+RNA NOUN O
+synthesis NOUN O
+using VERB O
+the DET O
+T7 PROPN O
+Megascript PROPN O
+kit NOUN O
+( PUNCT O
+Ambion PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+15 NUM O
+μg NOUN O
+of ADP O
+double ADJ B-LF
+- PUNCT I-LF
+stranded ADJ I-LF
+RNA NOUN I-LF
+( PUNCT O
+dsRNA NOUN B-AC
+) PUNCT O
+were AUX O
+added VERB O
+to ADP O
+106 NUM O
+cells NOUN O
+in ADP O
+all DET O
+RNAi NOUN B-AC
+experiments NOUN O
+. PUNCT O
+
+Clinical PROPN O
+and CCONJ O
+neuropsychological ADJ O
+data NOUN O
+were AUX O
+reviewed VERB O
+at ADP O
+multidisciplinary ADJ O
+consensus NOUN O
+case NOUN O
+conferences NOUN O
+if SCONJ O
+they PRON O
+made VERB O
+four NUM O
+or CCONJ O
+more ADJ O
+errors NOUN O
+on ADP O
+the DET O
+Blessed PROPN B-LF
+Information PROPN I-LF
+, PUNCT I-LF
+Memory PROPN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+Concentration PROPN I-LF
+( PUNCT O
+BIMC PROPN B-AC
+) PUNCT O
+test NOUN O
+, PUNCT O
+if SCONJ O
+their PRON O
+Clinical PROPN B-LF
+Dementia PROPN I-LF
+Rating PROPN I-LF
+( PUNCT O
+CDR PROPN B-AC
+) PUNCT O
+score NOUN O
+was AUX O
+equal ADJ O
+to ADP O
+or CCONJ O
+greater ADJ O
+than ADP O
+0.5 NUM O
+, PUNCT O
+or CCONJ O
+if SCONJ O
+concerns NOUN O
+were AUX O
+raised VERB O
+about ADP O
+their PRON O
+cognitive ADJ O
+status NOUN O
+by ADP O
+a DET O
+reliable ADJ O
+informant NOUN O
+. PUNCT O
+
+Fatality NOUN O
+rates NOUN O
+were AUX O
+analyzed VERB O
+according VERB O
+to ADP O
+hospitalization NOUN O
+, PUNCT O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+( PUNCT O
+ICU PROPN B-AC
+) PUNCT O
+admission NOUN O
+, PUNCT O
+and CCONJ O
+mechanical ADJ B-LF
+ventilation NOUN I-LF
+( PUNCT O
+MV PROPN B-AC
+) PUNCT O
+requirement NOUN O
+. PUNCT O
+
+CFU PROPN B-AC
+, PUNCT O
+colony NOUN B-LF
+forming VERB I-LF
+unit NOUN I-LF
+. PUNCT O
+
+Indeed ADV O
+, PUNCT O
+increased VERB O
+expression NOUN O
+of ADP O
+genes NOUN O
+in ADP O
+NF PROPN B-AC
+- PUNCT B-AC
+κB PROPN B-AC
+pathway NOUN O
+in ADP O
+human ADJ O
+patient NOUN O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PBMCs PROPN B-AC
+) PUNCT O
+was AUX O
+observed VERB O
+in ADP O
+single ADJ O
+- PUNCT O
+cell NOUN O
+RNA NOUN O
+sequencing NOUN O
+[ PUNCT O
+29 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+stage NOUN O
+one NUM O
+, PUNCT O
+after SCONJ O
+the DET O
+nine NUM O
+administrative ADJ O
+units NOUN O
+were AUX O
+stratified VERB O
+into ADP O
+12 NUM O
+urban ADJ O
+and CCONJ O
+11 NUM O
+rural ADJ O
+strata NOUN O
+, PUNCT O
+Enumeration PROPN B-LF
+Areas PROPN I-LF
+( PUNCT O
+EAs PROPN B-AC
+) PUNCT O
+were AUX O
+selected VERB O
+proportional ADJ O
+to ADP O
+the DET O
+household NOUN O
+size NOUN O
+of ADP O
+the DET O
+cluster NOUN O
+. PUNCT O
+
+Chlorophyll NOUN B-LF
+( PUNCT O
+Chl PROPN B-AC
+) PUNCT O
+was AUX O
+extracted VERB O
+from ADP O
+fresh ADJ O
+leaf NOUN O
+tissue NOUN O
+treated VERB O
+with ADP O
+25 NUM O
+mL NOUN O
+of ADP O
+ethanol NOUN O
+/ NOUN O
+acetone NOUN O
+( PUNCT O
+1/1 NUM O
+, PUNCT O
+v NOUN O
+/ NOUN O
+v NOUN O
+) PUNCT O
+for ADP O
+24 NUM O
+h NOUN O
+in ADP O
+the DET O
+dark NOUN O
+. PUNCT O
+
+Another DET O
+strength NOUN O
+of ADP O
+the DET O
+kSORT PROPN B-AC
+assay NOUN O
+is AUX O
+its PRON O
+high ADJ O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+PPV NOUN B-AC
+) NOUN O
+( PUNCT O
+93.21 NUM O
+% NOUN O
+) NOUN O
+for ADP O
+detecting VERB O
+AR PROPN B-AC
+in ADP O
+a DET O
+PB PROPN B-AC
+sample NOUN O
+. PUNCT O
+
+Moreover ADV O
+, PUNCT O
+lactate NOUN B-LF
+dehydrogenase NOUN I-LF
+( PUNCT O
+LDH PROPN B-AC
+) PUNCT O
+analysis NOUN O
+of ADP O
+co ADJ O
+- ADJ O
+culture ADJ O
+supernatants NOUN O
+indicated VERB O
+that SCONJ O
+cytochalasin NOUN O
+D NOUN O
+concentration NOUN O
+employed VERB O
+in ADP O
+these DET O
+studies NOUN O
+was AUX O
+not PART O
+cytotoxic ADJ O
+to ADP O
+alveolar ADJ O
+macrophages NOUN O
+( PUNCT O
+unpublished ADJ O
+data NOUN O
+) PUNCT O
+. PUNCT O
+
+During ADP O
+the DET O
+entry NOUN O
+process NOUN O
+, PUNCT O
+the DET O
+human ADJ B-LF
+immunodeficiency NOUN I-LF
+virus NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+HIV-1 PROPN B-AC
+) PUNCT O
+envelope NOUN B-LF
+glycoprotein NOUN I-LF
+( PUNCT O
+Env PROPN B-AC
+) PUNCT O
+trimer NOUN O
+undergoes VERB O
+a DET O
+sequence NOUN O
+of ADP O
+conformational ADJ O
+changes NOUN O
+triggered VERB O
+by ADP O
+both CCONJ O
+CD4 NOUN O
+and CCONJ O
+coreceptor NOUN O
+engagement NOUN O
+. PUNCT O
+
+To PART O
+avoid VERB O
+cases NOUN O
+of ADP O
+unclear ADJ O
+orthology NOUN O
+, PUNCT O
+we PRON O
+required VERB O
+both DET O
+genes NOUN O
+to PART O
+be AUX O
+the DET O
+only ADJ O
+members NOUN O
+of ADP O
+their PRON O
+respective ADJ O
+COGs NOUN B-AC
+( PUNCT O
+conserved VERB B-LF
+orthologous ADJ I-LF
+groups NOUN I-LF
+[ X O
+36 NUM O
+] X O
+in ADP O
+E. PROPN O
+coli PROPN O
+K12 PROPN O
+( PUNCT O
+see VERB O
+Materials NOUN O
+and CCONJ O
+Methods NOUN O
+) PUNCT O
+. PUNCT O
+
+OS PROPN B-AC
+, PUNCT O
+overall ADJ B-LF
+survival NOUN I-LF
+; PUNCT O
+PFS PROPN B-AC
+, PUNCT O
+progression NOUN B-LF
+- PUNCT I-LF
+free ADJ I-LF
+survival NOUN I-LF
+. PUNCT O
+
+In ADP O
+this DET O
+observational ADJ O
+study NOUN O
+we PRON O
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+all DET O
+fourth ADJ O
+- ADJ O
+year NOUN O
+undergraduate ADJ O
+medical ADJ O
+students NOUN O
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+a DET O
+French ADJ O
+medical ADJ O
+school NOUN O
+who PRON O
+undertook VERB O
+a DET O
+CS PROPN B-AC
+objective ADJ B-LF
+structured VERB I-LF
+clinical ADJ I-LF
+examination ADJ I-LF
+( PUNCT O
+OSCE PROPN B-AC
+) PUNCT O
+and CCONJ O
+who PRON O
+answered VERB O
+a DET O
+post ADJ O
+- ADJ O
+examination ADJ O
+survey NOUN O
+. PUNCT O
+
+DD PROPN B-AC
+, PUNCT O
+constant ADJ B-LF
+darkness NOUN I-LF
+. PUNCT O
+
+In ADP O
+145 NUM O
+healthy ADJ O
+, PUNCT O
+term NOUN O
+- PUNCT O
+born VERB O
+infants NOUN O
+( PUNCT O
+85 NUM O
+boys NOUN O
+) PUNCT O
+, PUNCT O
+we PRON O
+measured VERB O
+LTL NOUN B-AC
+in ADP O
+blood NOUN O
+, PUNCT O
+expressed VERB O
+as ADP O
+telomere NOUN B-LF
+to ADP I-LF
+single ADJ I-LF
+- PUNCT I-LF
+gene NOUN I-LF
+copy NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+T NOUN B-AC
+/ SYM B-AC
+S NOUN B-AC
+ratio NOUN B-AC
+) PUNCT O
+, PUNCT O
+at ADP O
+3 NUM O
+months NOUN O
+and CCONJ O
+2 NUM O
+years NOUN O
+by ADP O
+quantitative ADJ O
+PCR NOUN O
+technique NOUN O
+. PUNCT O
+
+These DET O
+offline ADJ O
+improvements NOUN O
+were AUX O
+linked VERB O
+to ADP O
+both PRON O
+replay NOUN O
+of ADP O
+task NOUN O
+- ADJ O
+related VERB O
+ensembles NOUN O
+during ADP O
+non ADJ B-LF
+- ADJ I-LF
+rapid ADJ I-LF
+eye NOUN I-LF
+movement NOUN I-LF
+( PUNCT O
+NREM PROPN B-AC
+) PUNCT O
+sleep NOUN O
+and CCONJ O
+temporal ADJ O
+shifts NOUN O
+that PRON O
+more ADV O
+tightly ADV O
+bound VERB O
+motor NOUN O
+cortical ADJ O
+ensembles NOUN O
+to ADP O
+movements NOUN O
+; PUNCT O
+such ADJ O
+offline ADJ O
+gains NOUN O
+and CCONJ O
+temporal ADJ O
+shifts NOUN O
+were AUX O
+not PART O
+evident ADJ O
+with ADP O
+sleep NOUN O
+restriction NOUN O
+. PUNCT O
+
+With ADP O
+this DET O
+expanded VERB O
+dataset NOUN O
+, PUNCT O
+we PRON O
+are AUX O
+able ADJ O
+to PART O
+put VERB O
+the DET O
+results NOUN O
+from ADP O
+Shaw PROPN O
+et X O
+al NOUN O
+. PUNCT O
+[ X O
+27 NUM O
+] X O
+in ADP O
+a DET O
+larger ADJ O
+context NOUN O
+, PUNCT O
+and CCONJ O
+determine VERB O
+whether SCONJ O
+there PRON O
+have AUX O
+been AUX O
+consistent ADJ O
+changes NOUN O
+in ADP O
+grassland NOUN O
+net NOUN B-LF
+primary ADJ I-LF
+production NOUN I-LF
+( PUNCT O
+NPP PROPN B-AC
+) PUNCT O
+that PRON O
+could AUX O
+directly ADV O
+affect VERB O
+the DET O
+amount NOUN O
+of ADP O
+C PROPN O
+stored VERB O
+in ADP O
+this DET O
+ecosystem NOUN O
+. PUNCT O
+
+To ADP O
+this DET O
+end NOUN O
+, PUNCT O
+we PRON O
+analyzed VERB O
+Dvl PROPN B-AC
+phosphorylation NOUN O
+in ADP O
+response NOUN O
+to ADP O
+Wnt5a PROPN O
+treatment NOUN O
+in ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+versus ADP O
+APP PROPN B-AC
+/ SYM O
+APLP2 PROPN O
+double ADJ B-LF
+knock ADJ I-LF
+- PUNCT I-LF
+out ADP I-LF
+mouse NOUN B-LF
+embryonic ADJ I-LF
+fibroblast NOUN I-LF
+( PUNCT O
+dKO PROPN B-AC
+MEFs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Microbial ADJ O
+community NOUN O
+analysis NOUN O
+was AUX O
+performed VERB O
+using VERB O
+the DET O
+Human PROPN B-LF
+Gut PROPN I-LF
+Chip PROPN I-LF
+( PUNCT O
+HuGChip PROPN B-AC
+) PUNCT O
+( PUNCT O
+GSE44752 PROPN O
+) PUNCT O
+as SCONJ O
+described VERB O
+[ PUNCT O
+29 NUM O
+] PUNCT O
+. PUNCT O
+
+Unexpectedly ADV O
+, PUNCT O
+we PRON O
+found VERB O
+that SCONJ O
+Notch1 NOUN O
+- PUNCT O
+expressing VERB O
+cells NOUN O
+invariably ADV O
+lacked VERB O
+the DET O
+expression NOUN O
+of ADP O
+ERα NOUN B-AC
+and CCONJ O
+PR NOUN B-AC
+( PUNCT O
+Fig NOUN O
+. PUNCT O
+2F NUM O
+, PUNCT O
+G NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+we PRON O
+confirmed VERB O
+these DET O
+results NOUN O
+by ADP O
+quantitative ADJ B-LF
+Real ADJ I-LF
+Time PROPN I-LF
+Polymerase PROPN I-LF
+Chain PROPN I-LF
+Reaction PROPN I-LF
+( PUNCT O
+qRT NOUN B-AC
+- PUNCT B-AC
+PCR PROPN B-AC
+) PUNCT O
+in ADP O
+sorted VERB O
+GFP PROPN B-AC
+- PUNCT O
+labeled VERB O
+cells NOUN O
+( PUNCT O
+S3B NOUN O
+, PUNCT O
+C NOUN O
+Fig NOUN O
+. PUNCT O
+) PUNCT O
+. PUNCT O
+
+The DET O
+lectin NOUN O
+staining NOUN O
+was AUX O
+demonstrated VERB O
+with ADP O
+fluorescently ADV O
+labeled VERB O
+Concavalia PROPN O
+ensiformis NOUN O
+( PUNCT O
+ConA PROPN B-AC
+) PUNCT O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+, PUNCT O
+Lycopersicon NOUN B-LF
+esculentum NOUN I-LF
+lectin NOUN I-LF
+( PUNCT O
+LEL PROPN B-AC
+) PUNCT O
+[ PUNCT O
+19 NUM O
+] PUNCT O
+, PUNCT O
+Sambucus NOUN O
+nigra NOUN O
+( PUNCT O
+SNL PROPN B-AC
+) PUNCT O
+[ PUNCT O
+20 NUM O
+] PUNCT O
+, PUNCT O
+Solanum NOUN O
+tuberosum NOUN O
+( PUNCT O
+STA PROPN B-AC
+) PUNCT O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+and CCONJ O
+wheat NOUN B-LF
+germ NOUN I-LF
+agglutinin NOUN I-LF
+( PUNCT O
+WGA PROPN B-AC
+) PUNCT O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+Light ADJ O
+, PUNCT O
+light ADJ O
+- PUNCT O
+intensity NOUN O
+activity NOUN O
+; PUNCT O
+MVPA PROPN B-AC
+, PUNCT O
+moderate ADJ B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+vigorous ADJ I-LF
+physical ADJ I-LF
+activity NOUN I-LF
+; PUNCT O
+Sed PROPN O
+, PUNCT O
+sedentary ADJ O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+ADL PROPN B-AC
+, PUNCT O
+activities NOUN B-LF
+of ADP I-LF
+daily ADJ I-LF
+living NOUN I-LF
+; PUNCT O
+BMI PROPN O
+, PUNCT O
+body NOUN O
+mass NOUN O
+index NOUN O
+; PUNCT O
+CON PROPN O
+, PUNCT O
+Control NOUN O
+; PUNCT O
+CVD NOUN B-AC
+, PUNCT O
+Cardiovascular ADJ B-LF
+disease NOUN I-LF
+; PUNCT O
+FLIP PROPN B-AC
+, PUNCT O
+Flooring PROPN B-LF
+for ADP I-LF
+Injury PROPN I-LF
+Prevention PROPN I-LF
+; PUNCT O
+INT PROPN O
+, PUNCT O
+intervention NOUN O
+; PUNCT O
+TIA PROPN B-AC
+, PUNCT O
+transient ADJ B-LF
+ischemic ADJ I-LF
+attack NOUN I-LF
+. PUNCT O
+
+FEL PROPN B-AC
+: PUNCT O
+fixed VERB B-LF
+- PUNCT I-LF
+effects NOUN I-LF
+likelihood NOUN I-LF
+; PUNCT O
+FUBAR PROPN B-AC
+: PUNCT O
+fast ADJ B-LF
+unconstrained ADJ I-LF
+Bayesian ADJ I-LF
+approximation NOUN I-LF
+; PUNCT O
+IFEL PROPN B-AC
+: PUNCT O
+random ADJ B-LF
+- PUNCT I-LF
+effects NOUN I-LF
+likelihood NOUN I-LF
+; PUNCT O
+MEME PROPN B-AC
+: PUNCT O
+mixed VERB B-LF
+- PUNCT I-LF
+effects NOUN I-LF
+model NOUN I-LF
+of ADP I-LF
+evolution NOUN I-LF
+; PUNCT O
+REL PROPN B-AC
+: PUNCT O
+internal ADJ B-LF
+branch NOUN I-LF
+fixed VERB I-LF
+- PUNCT I-LF
+effects NOUN I-LF
+likelihood NOUN I-LF
+; PUNCT O
+SLAC PROPN B-AC
+: PUNCT O
+single ADJ O
+- PUNCT O
+likelihood NOUN O
+ancestor NOUN O
+. PUNCT O
+
+They PRON O
+have VERB O
+important ADJ O
+roles NOUN O
+in ADP O
+receptor NOUN B-LF
+tyrosine NOUN I-LF
+kinase NOUN I-LF
+( PUNCT O
+RTK PROPN B-AC
+) PUNCT O
+and CCONJ O
+Notch PROPN O
+signalling NOUN O
+, PUNCT O
+highlighted VERB O
+by ADP O
+phenotypic ADJ O
+resemblance NOUN O
+of ADP O
+ADAM PROPN B-AC
+10/17 NUM O
+knockouts NOUN O
+with ADP O
+those PRON O
+of ADP O
+Notch PROPN O
+, PUNCT O
+the DET O
+epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+EGFR PROPN B-AC
+) PUNCT O
+and CCONJ O
+EGFR PROPN B-AC
+ligands NOUN O
+[ PUNCT O
+2],[3],[4],[5 NUM O
+] PUNCT O
+. PUNCT O
+
+Charlson PROPN B-LF
+Comorbidity PROPN I-LF
+Index PROPN I-LF
+( PUNCT O
+CCI PROPN B-AC
+) PUNCT O
+[ X O
+31 NUM O
+] X O
+was AUX O
+used VERB O
+to PART O
+categorize VERB O
+comorbidity NOUN O
+of ADP O
+the DET O
+patients NOUN O
+. PUNCT O
+
+A DET O
+population NOUN O
+of ADP O
+10,000 NUM O
+living VERB O
+cells NOUN O
+was AUX O
+captured VERB O
+and CCONJ O
+analyzed VERB O
+, PUNCT O
+and CCONJ O
+all DET O
+fluorescence NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+cell NOUN I-LF
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+( PUNCT O
+FACS PROPN B-AC
+) PUNCT O
+experiments NOUN O
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+performed VERB O
+using VERB O
+MOFLO PROPN O
+ASTRIOS PROPN O
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+( PUNCT O
+BECKMAN PROPN O
+COULTER PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
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+software NOUN O
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+. PUNCT O
+
+SP NOUN B-AC
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+. PUNCT O
+
+Chronic ADJ O
+kidney NOUN O
+disease NOUN O
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+defined VERB O
+as ADP O
+an DET O
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+( PUNCT O
+eGFR PROPN B-AC
+) PUNCT O
+< ADP O
+60 NUM O
+ml NOUN O
+/ SYM O
+min/1.73m2 NUM O
+by ADP O
+the PRON O
+Modification PROPN O
+of ADP O
+Diet PROPN O
+in ADP O
+Renal PROPN O
+Disease PROPN O
+formula.[24 NOUN O
+] PUNCT O
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+( PUNCT O
+HFPEF PROPN B-AC
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+defined VERB O
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+( PUNCT O
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+≥40%.[25 NUM O
+] PUNCT O
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+CHA2DS2 PROPN O
+- PUNCT O
+VASc PROPN O
+score NOUN O
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+each DET O
+patient NOUN O
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+( PUNCT O
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+: PUNCT O
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+heart NOUN B-LF
+failure NOUN I-LF
+[ PUNCT O
+1 NUM O
+point NOUN O
+] PUNCT O
+; PUNCT O
+H NOUN O
+: PUNCT O
+hypertension NOUN O
+[ PUNCT O
+1 NUM O
+point NOUN O
+] PUNCT O
+; PUNCT O
+A2 X O
+: PUNCT O
+age NOUN O
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+years NOUN O
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+1 NUM O
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+] PUNCT O
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+years NOUN O
+[ PUNCT O
+2 NUM O
+points NOUN O
+] PUNCT O
+; PUNCT O
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+: PUNCT O
+diabetes NOUN O
+mellitus NOUN O
+[ PUNCT O
+1 NUM O
+point NOUN O
+] PUNCT O
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+stroke NOUN O
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+ischemic ADJ O
+attack NOUN O
+[ PUNCT O
+2 NUM O
+points NOUN O
+] PUNCT O
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+V NOUN O
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+vascular ADJ O
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+as ADP O
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+vascular ADJ O
+disease NOUN O
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+1 NUM O
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+= PUNCT O
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+] PUNCT O
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+RMSEA PROPN B-AC
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+MDCK PROPN B-AC
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+T PROPN O
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+, PUNCT O
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+( PUNCT O
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+) PUNCT O
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+monkey NOUN O
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+( PUNCT O
+Vero PROPN O
+) PUNCT O
+cells NOUN O
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+the DET O
+American PROPN O
+Type PROPN O
+Culture PROPN O
+Collection PROPN O
+( PUNCT O
+Manassas PROPN O
+, PUNCT O
+Virginia PROPN O
+, PUNCT O
+United PROPN O
+States PROPN O
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+America PROPN O
+) PUNCT O
+and CCONJ O
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+in ADP O
+the DET O
+appropriate ADJ O
+medium NOUN O
+( PUNCT O
+MDCK PROPN B-AC
+cells NOUN O
+: PUNCT O
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+Essential PROPN I-LF
+Medium PROPN I-LF
+Eagle PROPN I-LF
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+Earle PROPN O
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+BBS PROPN O
+( PUNCT O
+MEME PROPN B-AC
+) PUNCT O
+, PUNCT O
+Lonza PROPN O
+, PUNCT O
+Basel PROPN O
+, PUNCT O
+Switzerland PROPN O
+; PUNCT O
+293 PROPN O
+T PROPN O
+, PUNCT O
+A549 PROPN O
+, PUNCT O
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+( PUNCT O
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+) PUNCT O
+, PUNCT O
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+, PUNCT O
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+, PUNCT O
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+, PUNCT O
+USA PROPN O
+) PUNCT O
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+10 NUM O
+% NOUN O
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+37 NUM O
+° NOUN O
+C NOUN O
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+
+To PART O
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+all DET O
+selected VERB O
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+in ADP O
+vivo ADJ O
+, PUNCT O
+we PRON O
+employed VERB O
+a DET O
+protein NOUN O
+import NOUN O
+assay NOUN O
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+, PUNCT O
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+green ADJ I-LF
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+protein NOUN I-LF
+( PUNCT O
+EGFP)-tagged VERB B-AC
+AGT PROPN B-AC
+. PUNCT O
+When SCONJ O
+expressing VERB O
+EGFP PROPN B-AC
+- PUNCT O
+AGT PROPN B-AC
+without ADP O
+further ADJ O
+modification NOUN O
+in ADP O
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+we PRON O
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+that SCONJ O
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+than ADP O
+90 NUM O
+% NOUN O
+of ADP O
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+cells NOUN O
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+) PUNCT O
+. PUNCT O
+
+Additionally ADV O
+, PUNCT O
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+of ADP O
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+values NOUN I-LF
+( PUNCT O
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+) PUNCT O
+and CCONJ O
+longer ADJ O
+mean ADJ B-LF
+residence NOUN I-LF
+time NOUN I-LF
+( PUNCT O
+MRT NOUN B-AC
+) PUNCT O
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+significant ADJ O
+differences NOUN O
+. PUNCT O
+
+Secondary ADJ O
+outcomes NOUN O
+included VERB O
+BP PROPN B-AC
+score NOUN O
+, PUNCT O
+adenoma NOUN B-LF
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+rate NOUN I-LF
+( PUNCT O
+ADR PROPN B-AC
+) PUNCT O
+, PUNCT O
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+( PUNCT O
+PDR NOUN B-AC
+) PUNCT O
+, PUNCT O
+insertion NOUN O
+time NOUN O
+, PUNCT O
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+, PUNCT O
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+events NOUN O
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+80 NUM O
+% NOUN O
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+and CCONJ O
+diet NOUN O
+compliance NOUN O
+. PUNCT O
+
+d X O
+Mean NOUN O
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+AZ PROPN B-AC
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+, PUNCT O
+Bruchpilot NOUN B-LF
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+, PUNCT O
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+, PUNCT O
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+- PUNCT I-LF
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+
+Immobilized ADJ B-LF
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+( PUNCT O
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+( PUNCT O
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+, PUNCT O
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+and CCONJ O
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+prepared VERB O
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+with ADP O
+cup NOUN O
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+
+Empirical ADJ O
+studies NOUN O
+and CCONJ O
+population NOUN O
+- PUNCT O
+level NOUN O
+policy NOUN O
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+the DET O
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+( PUNCT O
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+. PUNCT O
+
+Diabetes PROPN O
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+. PUNCT O
+
+Colony NOUN B-LF
+- PUNCT I-LF
+forming VERB I-LF
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+° NOUN O
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+. PUNCT O
+
+In ADP O
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+, PUNCT O
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+( PUNCT O
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+CFU PROPN O
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+( PUNCT O
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+S2A PROPN O
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+) PUNCT O
+. PUNCT O
+
+Assumptions NOUN O
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+- PUNCT O
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+We PRON O
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+( PUNCT O
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+) PUNCT O
+, PUNCT O
+negative ADJ B-LF
+likelihood NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+NLR PROPN B-AC
+) PUNCT O
+, PUNCT O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+PPV PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+negative ADJ B-LF
+predictive ADJ I-LF
+values NOUN I-LF
+( PUNCT O
+NPVs NOUN B-AC
+) PUNCT O
+for ADP O
+each DET O
+score NOUN O
+. PUNCT O
+
+DKO PROPN B-AC
+, PUNCT O
+double ADJ B-LF
+knockout NOUN I-LF
+; PUNCT O
+LSK PROPN B-AC
+, PUNCT O
+Lin−Sca1+cKit+ NOUN O
+; PUNCT O
+RNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+RNA NOUN O
+sequencing NOUN O
+. PUNCT O
+
+SIS PROPN B-AC
+- PUNCT O
+ECM PROPN B-AC
+; PUNCT O
+Small ADJ B-LF
+intestinal ADJ I-LF
+submucosa NOUN I-LF
+extra ADJ B-LF
+cellular ADJ I-LF
+matrix NOUN I-LF
+. PUNCT O
+* PUNCT O
+Decellularized VERB O
+. PUNCT O
+
+OR NOUN B-AC
+, PUNCT O
+Odds NOUN B-LF
+Ratio NOUN I-LF
+; PUNCT O
+CI NOUN B-AC
+, PUNCT O
+Confidence NOUN B-LF
+Interval NOUN I-LF
+; PUNCT O
+ref NOUN O
+, PUNCT O
+reference NOUN O
+; PUNCT O
+N NOUN O
+, PUNCT O
+number NOUN O
+. PUNCT O
+
+MYLK PROPN B-AC
+encodes VERB O
+the DET O
+multi ADJ O
+- ADJ O
+functional ADJ O
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+light ADJ I-LF
+chain NOUN I-LF
+kinase NOUN I-LF
+( PUNCT O
+MLCK PROPN B-AC
+) PUNCT O
+which PRON O
+is AUX O
+involved ADJ O
+in ADP O
+diverse ADJ O
+functions NOUN O
+in ADP O
+multiple ADJ O
+types NOUN O
+of ADP O
+cancer NOUN O
+. PUNCT O
+
+To PART O
+prepare VERB O
+antibiotic ADJ O
+disc NOUN O
+we PRON O
+followed VERB O
+the DET O
+procedure NOUN O
+suggested VERB O
+by ADP O
+Clinical PROPN B-LF
+Laboratory PROPN I-LF
+Standard PROPN I-LF
+Institute PROPN I-LF
+( PUNCT O
+CLSI PROPN B-AC
+) PUNCT O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+metabolic ADJ O
+and CCONJ O
+dietary ADJ O
+factors NOUN O
+, PUNCT O
+external ADJ O
+validation NOUN O
+was AUX O
+performed VERB O
+by ADP O
+evaluating VERB O
+data NOUN O
+of ADP O
+the DET O
+US PROPN O
+National PROPN B-LF
+Health PROPN I-LF
+and CCONJ I-LF
+Nutrition PROPN I-LF
+Examination PROPN I-LF
+Survey PROPN I-LF
+( PUNCT O
+NHANES PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+A DET O
+further ADJ O
+change NOUN O
+that PRON O
+is AUX O
+likely ADJ O
+to PART O
+be AUX O
+required VERB O
+to PART O
+allow VERB O
+cells NOUN O
+using VERB O
+the DET O
+ALT PROPN B-AC
+pathway NOUN O
+to PART O
+escape VERB O
+telomere NOUN O
+crisis NOUN O
+is AUX O
+a DET O
+deficiency NOUN O
+in ADP O
+the DET O
+cyclic ADJ B-LF
+GMP PROPN I-LF
+- PUNCT I-LF
+AMP PROPN I-LF
+synthase NOUN I-LF
+( PUNCT O
+cGAS)–stimulator NOUN B-LF
+of ADP I-LF
+interferon NOUN I-LF
+genes NOUN I-LF
+( PUNCT O
+STING PROPN B-AC
+) PUNCT O
+pathway NOUN O
+. PUNCT O
+
+LiST PROPN B-AC
+, PUNCT O
+Lives NOUN B-LF
+Saved VERB I-LF
+Tool NOUN I-LF
+. PUNCT O
+
+Approval NOUN O
+for ADP O
+the DET O
+use NOUN O
+of ADP O
+anonymised ADJ O
+data NOUN O
+in ADP O
+this DET O
+study NOUN O
+was AUX O
+granted VERB O
+by ADP O
+an DET O
+independent ADJ O
+Information PROPN B-LF
+Governance PROPN I-LF
+Review PROPN I-LF
+Panel PROPN I-LF
+( PUNCT O
+IGRP PROPN B-AC
+) PUNCT O
+, PUNCT O
+with SCONJ O
+membership NOUN O
+comprised VERB O
+of ADP O
+senior ADJ O
+representatives NOUN O
+from ADP O
+the DET O
+British PROPN B-LF
+Medical PROPN I-LF
+Association PROPN I-LF
+( PUNCT O
+BMA PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+National PROPN B-LF
+Research PROPN I-LF
+Ethics PROPN I-LF
+Service PROPN I-LF
+( PUNCT O
+NRES PROPN B-AC
+) PUNCT O
+, PUNCT O
+Public PROPN B-LF
+Health PROPN I-LF
+Wales PROPN I-LF
+and CCONJ I-LF
+NHS PROPN I-LF
+Wales PROPN I-LF
+Informatics PROPN I-LF
+Service PROPN I-LF
+( PUNCT O
+NWIS PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Therefore ADV O
+the DET O
+local ADJ O
+authorities NOUN O
+at ADP O
+each DET O
+level NOUN O
+of ADP O
+health NOUN O
+sector NOUN O
+or CCONJ O
+the DET O
+nongovernmental ADJ O
+organizations NOUN O
+working VERB O
+to PART O
+improve VERB O
+maternal ADJ O
+health NOUN O
+need VERB O
+to PART O
+provide VERB O
+training NOUN O
+on ADP O
+focused VERB O
+antenatal ADJ B-LF
+care NOUN I-LF
+protocol NOUN O
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+ANC PROPN B-AC
+providers NOUN O
+. PUNCT O
+
+Obesity PROPN O
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+been AUX O
+consistently ADV O
+associated VERB O
+with ADP O
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+certain ADJ O
+chronic ADJ O
+diseases NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+( PUNCT O
+CVD NOUN B-AC
+) PUNCT O
+, PUNCT O
+type NOUN B-LF
+2 NUM I-LF
+diabetes NOUN I-LF
+( PUNCT O
+T2D NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+cancer NOUN O
+[ PUNCT O
+1–4 NUM O
+] PUNCT O
+. PUNCT O
+
+Important ADJ O
+differences NOUN O
+exist VERB O
+in ADP O
+the DET O
+diagnosis NOUN O
+of ADP O
+malnutrition NOUN O
+when SCONJ O
+comparing VERB O
+the DET O
+2006 NUM O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+Child PROPN O
+Growth PROPN O
+Standards PROPN O
+and CCONJ O
+the DET O
+1977 NUM O
+National PROPN B-LF
+Center PROPN I-LF
+for ADP I-LF
+Health PROPN I-LF
+Statistics PROPN I-LF
+( PUNCT O
+NCHS PROPN B-AC
+) PUNCT O
+reference NOUN O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+LTFU PROPN B-AC
+, PUNCT O
+loss NOUN B-LF
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+- PUNCT I-LF
+up NOUN I-LF
+; PUNCT O
+MPR PROPN B-AC
+, PUNCT O
+medication NOUN B-LF
+possession NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+
+1 NUM O
+Applies VERB O
+to ADP O
+CARE PROPN B-AC
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+II PROPN B-AC
+( PUNCT O
+Integrated PROPN B-LF
+Nutrition PROPN I-LF
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+Health PROPN I-LF
+Program–“Intervention PROPN I-LF
+district NOUN O
+” PUNCT O
+) PUNCT O
+. PUNCT O
+
+ChR2 PROPN B-AC
+, PUNCT O
+channelrhodopsin NOUN B-LF
+; PUNCT O
+F PROPN B-AC
+/ SYM B-AC
+F0 PROPN B-AC
+, PUNCT O
+fluorescence NOUN B-LF
+over ADP I-LF
+background NOUN I-LF
+; PUNCT O
+FFT PROPN B-AC
+, PUNCT O
+fast ADJ B-LF
+Fourier NOUN I-LF
+transform NOUN I-LF
+; PUNCT O
+GCaMP6 PROPN B-AC
+, PUNCT O
+circular ADJ B-LF
+permutated ADJ I-LF
+green ADJ I-LF
+florescent ADJ I-LF
+protein NOUN I-LF
+- PUNCT I-LF
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+M13 PROPN I-LF
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+6 NUM I-LF
+; PUNCT O
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+, PUNCT O
+Histone PROPN B-LF
+2B NUM I-LF
+; PUNCT O
+NLS PROPN O
+, PUNCT O
+nuclear ADJ O
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+sequence NOUN O
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+mutated VERB B-LF
+channelrhodopsin NOUN I-LF
+; PUNCT O
+YFP PROPN O
+, PUNCT O
+yellow ADJ O
+fluorescent ADJ O
+protein NOUN O
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+
+Note VERB O
+: PUNCT O
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+represent VERB O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+. PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+relative ADJ B-LF
+risk NOUN I-LF
+. PUNCT O
+
+Bioluminescence NOUN B-LF
+resonance NOUN I-LF
+energy NOUN I-LF
+transfer NOUN I-LF
+( PUNCT O
+BRET PROPN B-AC
+) PUNCT O
+plasmids NOUN O
+were AUX O
+created VERB O
+and CCONJ O
+synthesized VERB O
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+Genscript PROPN O
+( PUNCT O
+Piscataway PROPN O
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+) PUNCT O
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+- PUNCT B-AC
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+- PUNCT B-AC
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+- PUNCT B-AC
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+) PUNCT O
+. PUNCT O
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+GSEA PROPN B-AC
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+biological ADJ O
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+Underlying VERB O
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+RU486 NOUN B-AC
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+Control NOUN O
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+shown VERB O
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+Herskowitz PROPN I-LF
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+( PUNCT O
+LBH PROPN B-AC
+) PUNCT O
+containing VERB O
+100 NUM O
+μg NOUN O
+/ SYM O
+ml NOUN O
+chloramphenicol NOUN O
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+whereas SCONJ O
+Lac+ NOUN O
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+- PUNCT O
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+cells NOUN O
+, PUNCT O
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+those PRON O
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+
+The DET O
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+the DET O
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+
+ACT PROPN B-AC
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+
+CI PROPN B-AC
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+) PUNCT O
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+genital ADJ O
+tract NOUN O
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+OSOM PROPN O
+Trichomonas PROPN O
+and CCONJ O
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+Blue PROPN O
+( PUNCT O
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+Lexington PROPN O
+, PUNCT O
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+) PUNCT O
+, PUNCT O
+and CCONJ O
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+Determine PROPN O
+Syphilis PROPN O
+( PUNCT O
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+, PUNCT O
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+, PUNCT O
+USA PROPN O
+) PUNCT O
+RDT NOUN B-AC
+for ADP O
+whole ADJ O
+blood NOUN O
+with ADP O
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+Rapid PROPN O
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+Reagin PROPN O
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+according VERB O
+to ADP O
+package NOUN O
+instructions NOUN O
+. PUNCT O
+
+To PART O
+determine VERB O
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+( PUNCT O
+CNS PROPN B-AC
+) PUNCT O
+hemangioblastomas NOUN O
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+von PROPN B-LF
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+, PUNCT O
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+characterized VERB O
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+differentiated VERB O
+neoplastic ADJ O
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+hemangioblastomas NOUN O
+removed VERB O
+from ADP O
+VHL PROPN B-AC
+patients NOUN O
+. PUNCT O
+
+Flies NOUN O
+detect VERB O
+volatile ADJ O
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+other ADJ O
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+courtship NOUN O
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+olfactory ADJ B-LF
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+( PUNCT O
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+) PUNCT O
+expressed VERB O
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+12 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
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+) PUNCT O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+http://neurovault.org/collections/2503/. X O
+
+Instead ADV O
+, PUNCT O
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+mice NOUN O
+lacking VERB O
+the DET O
+adaptor NOUN O
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+domain NOUN I-LF
+- PUNCT I-LF
+containing VERB I-LF
+leukocyte NOUN I-LF
+protein-76 NOUN I-LF
+( PUNCT O
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+) PUNCT O
+. PUNCT O
+
+The DET O
+World PROPN O
+Health PROPN O
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+) PUNCT O
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+( PUNCT O
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+- ADJ B-AC
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+) PUNCT O
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+3 NUM O
+] PUNCT O
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+
+Diagnostics NOUN O
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+( PUNCT O
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+
+Activation NOUN O
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+GαS PROPN O
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+PKA PROPN B-AC
+. PUNCT O
+Unknown ADJ O
+PKA PROPN B-AC
+substrates NOUN O
+likely ADV O
+trigger VERB O
+in ADP O
+parallel ADJ O
+Cdk1 PROPN O
+activation NOUN O
+and CCONJ O
+thus ADV O
+GVBD PROPN B-AC
+, PUNCT O
+and CCONJ O
+Mos1 PROPN O
+synthesis NOUN O
+to PART O
+initiate VERB O
+the DET O
+MAPK PROPN O
+cascade NOUN O
+. PUNCT O
+; PUNCT O
+Br PROPN B-AC
+- PUNCT B-AC
+cAMP NOUN B-AC
+, PUNCT O
+bromoadenosine NOUN B-LF
+3′,5′-cyclic NOUN I-LF
+monophosphate NOUN I-LF
+; PUNCT O
+GST PROPN B-AC
+, PUNCT O
+Glutathione PROPN B-LF
+- PUNCT I-LF
+S PROPN I-LF
+- PUNCT I-LF
+Transferase PROPN I-LF
+; PUNCT O
+GVBD PROPN B-AC
+, PUNCT O
+germinal ADJ B-LF
+vesicle NOUN I-LF
+breakdown NOUN I-LF
+; PUNCT O
+MIH PROPN B-AC
+, PUNCT O
+maturation NOUN B-LF
+- PUNCT I-LF
+inducing VERB I-LF
+hormone NOUN I-LF
+; PUNCT O
+MIHR PROPN B-AC
+, PUNCT O
+MIH PROPN B-LF
+receptor NOUN I-LF
+; PUNCT O
+PKA PROPN B-AC
+, PUNCT O
+protein NOUN O
+kinase NOUN O
+A. NOUN O
+
+As ADP O
+part NOUN O
+of ADP O
+quality NOUN B-LF
+control NOUN I-LF
+( PUNCT O
+QC PROPN B-AC
+) PUNCT O
+, NOUN O
+the DET O
+following ADJ O
+were AUX O
+excluded VERB O
+: PUNCT O
+SNP NOUN B-AC
+markers NOUN O
+with ADP O
+unknown ADJ O
+genomic ADJ O
+position NOUN O
+, NOUN O
+located VERB O
+on ADP O
+sex NOUN O
+chromosomes NOUN O
+, NOUN O
+monomorphic ADJ O
+and CCONJ O
+markers NOUN O
+with ADP O
+minor ADJ O
+allele NOUN O
+frequency NOUN O
+( PUNCT O
+MAF PROPN O
+) PUNCT O
+bellow NOUN O
+0.05 NUM O
+, NOUN O
+call NOUN O
+rate NOUN O
+bellow NOUN O
+90 NUM O
+% NOUN O
+, NOUN O
+with ADP O
+excess ADJ O
+markers NOUN O
+heterozygous ADJ O
+genotypes NOUN O
+and CCONJ O
+those PRON O
+who PRON O
+had VERB O
+a DET O
+mean ADJ O
+intensity NOUN O
+of ADP O
+the DET O
+low ADJ O
+cluster NOUN O
+. PUNCT O
+
+Typhimurium NOUN O
+, PUNCT O
+S. PROPN O
+enterica NOUN O
+serovar NOUN O
+Typhimurium NOUN O
+; PUNCT O
+SCFA PROPN B-AC
+, PUNCT O
+short ADJ B-LF
+- PUNCT I-LF
+chain NOUN I-LF
+fatty ADJ I-LF
+acid NOUN I-LF
+. PUNCT O
+
+The DET O
+terms NOUN O
+Positive PROPN B-LF
+Percent NOUN I-LF
+Agreement PROPN I-LF
+( PUNCT O
+PPA PROPN B-AC
+) PUNCT O
+and CCONJ O
+Negative PROPN B-LF
+Percent NOUN I-LF
+Agreement PROPN I-LF
+( PUNCT O
+NPA PROPN B-AC
+) PUNCT O
+should AUX O
+be AUX O
+used VERB O
+in ADP O
+place NOUN O
+of ADP O
+Sensitivity PROPN O
+and CCONJ O
+Specificity PROPN O
+, PUNCT O
+respectively ADV O
+, PUNCT O
+when SCONJ O
+the DET O
+comparator NOUN O
+is AUX O
+known VERB O
+to PART O
+contain VERB O
+uncertainty NOUN O
+. PUNCT O
+
+The DET O
+model NOUN O
+'s PART O
+primary ADJ O
+outcome NOUN O
+measure NOUN O
+is AUX O
+the DET O
+cost NOUN O
+per ADP O
+disability NOUN B-LF
+adjusted VERB I-LF
+life NOUN I-LF
+year NOUN I-LF
+( PUNCT O
+DALY PROPN B-AC
+) PUNCT O
+averted VERB O
+. PUNCT O
+
+Mice NOUN O
+were AUX O
+exposed VERB O
+to ADP O
+blue ADJ O
+and CCONJ O
+green ADJ O
+light NOUN O
+stimuli NOUN O
+and CCONJ O
+after ADP O
+30 NUM O
+min NOUN O
+SCN PROPN B-AC
+and CCONJ O
+VLPO PROPN B-AC
+were AUX O
+collected VERB O
+for ADP O
+gene NOUN O
+expression NOUN O
+analysis NOUN O
+using VERB O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+( PUNCT O
+qPCR NOUN B-AC
+) PUNCT O
+. PUNCT O
+Consistent ADJ O
+with ADP O
+our PRON O
+previous ADJ O
+findings NOUN O
+( PUNCT O
+Fig NOUN O
+4A NUM O
+) PUNCT O
+, PUNCT O
+we PRON O
+found VERB O
+that SCONJ O
+blue ADJ O
+light NOUN O
+produced VERB O
+a DET O
+larger ADJ O
+Fos PROPN O
+induction NOUN O
+in ADP O
+the DET O
+SCN PROPN B-AC
+than ADP O
+green ADJ O
+light NOUN O
+. PUNCT O
+
+C NOUN B-AC
+- PUNCT B-AC
+value NOUN B-AC
+; PUNCT O
+DNA NOUN B-LF
+content NOUN I-LF
+value NOUN I-LF
+; PUNCT O
+CW PROPN B-AC
+, PUNCT O
+critical ADJ B-LF
+weight NOUN I-LF
+; PUNCT O
+L2 NOUN B-AC
+, PUNCT O
+second ADJ B-LF
+instar NOUN I-LF
+; PUNCT O
+L3 PROPN B-AC
+, PUNCT O
+third ADJ B-LF
+instar NOUN I-LF
+; PUNCT O
+PG PROPN B-AC
+, PUNCT O
+prothoracic ADJ B-LF
+gland NOUN I-LF
+; PUNCT O
+TOR PROPN B-AC
+, PUNCT O
+target NOUN B-LF
+of ADP I-LF
+rapamycin NOUN I-LF
+. PUNCT O
+
+HT NOUN O
+, PUNCT O
+heterozygous ADJ O
+; PUNCT O
+ns NOUN B-AC
+, PUNCT O
+not PART B-LF
+significant ADJ I-LF
+; PUNCT O
+P NOUN O
+, PUNCT O
+postnatal ADJ O
+day NOUN O
+; PUNCT O
+WT NOUN B-AC
+, PUNCT O
+wild ADJ B-LF
+type NOUN I-LF
+. PUNCT O
+
+fH NOUN B-AC
+= VERB O
+heart NOUN B-LF
+rate NOUN I-LF
+; PUNCT O
+PI NOUN B-AC
+= VERB O
+pulse NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+Ps NOUN B-AC
+= VERB O
+systolic ADJ O
+pressure NOUN O
+; PUNCT O
+Pd NOUN B-AC
+= VERB O
+diastolic ADJ O
+pressure NOUN O
+; PUNCT O
+Pm NOUN B-AC
+= VERB O
+mean ADJ B-LF
+arterial ADJ I-LF
+pressure NOUN I-LF
+; PUNCT O
+Pp NOUN B-AC
+= VERB O
+pulse NOUN B-LF
+pressure NOUN I-LF
+; PUNCT O
+Gop NOUN B-AC
+= VERB O
+baroreflex ADJ B-LF
+gain NOUN I-LF
+at ADP I-LF
+the DET I-LF
+operating NOUN I-LF
+point NOUN I-LF
+; PUNCT O
+BEI NOUN B-AC
+= VERB O
+baroreflex ADJ B-LF
+effectiveness NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+τ NOUN O
+= VERB O
+pressure NOUN O
+decay NOUN O
+time NOUN O
+constant ADJ O
+; PUNCT O
+τ NOUN O
+/ SYM O
+PI NOUN B-AC
+= VERB O
+ratio NOUN O
+between ADP O
+pressure NOUN O
+decay NOUN O
+time NOUN O
+constant ADJ O
+and CCONJ O
+pulse NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+OPF NOUN B-AC
+= VERB O
+oscillatory ADJ B-LF
+power NOUN I-LF
+fraction NOUN I-LF
+. PUNCT O
+
+This DET O
+study NOUN O
+is AUX O
+a DET O
+secondary ADJ O
+data NOUN O
+analysis NOUN O
+of ADP O
+the DET O
+2015–16 NUM O
+Myanmar PROPN B-LF
+Demographic PROPN I-LF
+and CCONJ I-LF
+Health PROPN I-LF
+Survey PROPN I-LF
+( PUNCT O
+MDHS PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+a DET O
+cross ADJ O
+- PUNCT O
+sectional ADJ O
+nationally ADV O
+representative ADJ O
+population NOUN O
+- PUNCT O
+based VERB O
+survey NOUN O
+. PUNCT O
+
+In ADP O
+this DET O
+assay NOUN O
+, PUNCT O
+a DET O
+premixed VERB O
+Annexin PROPN O
+V PROPN O
+in ADP O
+combination NOUN O
+with ADP O
+a DET O
+dead ADJ O
+cell NOUN O
+marker NOUN O
+, PUNCT O
+7 NUM B-LF
+- PUNCT I-LF
+amino NOUN I-LF
+actinomycin NOUN I-LF
+( PUNCT O
+7 NUM B-AC
+- PUNCT B-AC
+AAD PROPN B-AC
+) PUNCT O
+is AUX O
+used VERB O
+. PUNCT O
+
+The DET O
+source NOUN O
+population NOUN O
+were AUX O
+all PRON O
+records NOUN O
+children NOUN O
+aged ADJ O
+6–59 NUM O
+months NOUN O
+with ADP O
+SAM PROPN B-AC
+admitted VERB O
+to ADP O
+Therapeutic PROPN B-LF
+Feeding PROPN I-LF
+Center PROPN I-LF
+( PUNCT O
+TFC PROPN B-AC
+) PUNCT O
+at ADP O
+the DET O
+UOGCSH PROPN B-AC
+from ADP O
+January1/2014 NUM O
+to ADP O
+December PROPN O
+30/ NUM O
+2016 NUM O
+. PUNCT O
+
+Human ADJ O
+monocytes NOUN O
+are AUX O
+broadly ADV O
+classified VERB O
+into ADP O
+three NUM O
+phenotypically ADV O
+and CCONJ O
+functionally ADV O
+distinct ADJ O
+subsets NOUN O
+, PUNCT O
+based VERB O
+on ADP O
+CD14 PROPN O
+and CCONJ O
+CD16 PROPN O
+expression NOUN O
+; PUNCT O
+which PRON O
+likely ADV O
+represent VERB O
+different ADJ O
+stages NOUN O
+of ADP O
+maturity NOUN O
+and CCONJ O
+differentiation NOUN O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+‘ PUNCT O
+Classical ADJ O
+’ PUNCT O
+CD14high NOUN O
+/ SYM O
+CD16- NOUN O
+monocytes NOUN O
+( PUNCT O
+comprising VERB O
+~80 NUM O
+% NOUN O
+of ADP O
+peripheral ADJ O
+blood NOUN O
+monocytes NOUN O
+) PUNCT O
+express VERB O
+high ADJ O
+levels NOUN O
+of ADP O
+chemokine NOUN B-LF
+( PUNCT I-LF
+C PROPN I-LF
+- PUNCT I-LF
+C PROPN I-LF
+motif NOUN I-LF
+) PUNCT I-LF
+receptor NOUN I-LF
+( PUNCT O
+CCR)2 PROPN B-AC
+and CCONJ O
+exhibit VERB O
+strong ADJ O
+phagocytic ADJ O
+capacity NOUN O
+. PUNCT O
+
+ALS PROPN B-AC
+, PUNCT O
+amyotrophic ADJ B-LF
+lateral ADJ I-LF
+sclerosis NOUN I-LF
+; PUNCT O
+CI NOUN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+LOS NOUN O
+, PUNCT O
+length NOUN O
+of ADP O
+stay NOUN O
+; PUNCT O
+NA NOUN O
+, PUNCT O
+not PART O
+applicable ADJ O
+; PUNCT O
+NDD NOUN B-AC
+, PUNCT O
+neurodegenerative ADJ B-LF
+disease NOUN I-LF
+; PUNCT O
+PD NOUN B-AC
+, PUNCT O
+Parkinson PROPN B-LF
+disease NOUN I-LF
+; PUNCT O
+TBI PROPN B-AC
+, PUNCT O
+traumatic ADJ B-LF
+brain NOUN I-LF
+injury NOUN I-LF
+. PUNCT O
+
+SD NOUN B-AC
+: PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+DM NOUN B-AC
+: PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+, PUNCT O
+GERD NOUN B-AC
+: PUNCT O
+gastroesophageal ADJ O
+reflux NOUN O
+disease NOUN O
+
+We PRON O
+classified VERB O
+each DET O
+EOC PROPN B-AC
+into ADP O
+five NUM O
+groups NOUN O
+based VERB O
+on ADP O
+their PRON O
+troponin NOUN O
+pattern NOUN O
+and CCONJ O
+primary ADJ O
+/ SYM O
+secondary ADJ O
+discharge NOUN O
+diagnoses NOUN O
+to PART O
+maximally ADV O
+align VERB O
+with ADP O
+the DET O
+Fourth PROPN O
+Universal PROPN O
+Definition PROPN O
+of ADP O
+MI PROPN B-AC
+. PUNCT O
+Episodes NOUN B-LF
+of ADP I-LF
+care NOUN I-LF
+rather ADV O
+than ADP O
+individual NOUN O
+patient NOUN O
+- PUNCT O
+level NOUN O
+analysis NOUN O
+was AUX O
+chosen VERB O
+as SCONJ O
+pattern NOUN O
+characterisation NOUN O
+of ADP O
+hs NOUN O
+- PUNCT O
+cTnT NOUN O
+allows VERB O
+for ADP O
+dynamic ADJ O
+risk NOUN O
+assessment NOUN O
+which PRON O
+is AUX O
+expected VERB O
+to PART O
+vary VERB O
+in ADP O
+an DET O
+individual NOUN O
+over ADP O
+time NOUN O
+. PUNCT O
+
+NCBI PROPN B-AC
+, PUNCT O
+National PROPN B-LF
+Center PROPN I-LF
+for ADP I-LF
+Biotechnology PROPN I-LF
+Information PROPN I-LF
+; PUNCT O
+TOM PROPN B-AC
+, PUNCT O
+translocase NOUN B-LF
+of ADP I-LF
+the DET I-LF
+outer ADJ I-LF
+membrane NOUN I-LF
+; PUNCT O
+TvTom PROPN O
+, PUNCT O
+T. NOUN O
+vaginalis NOUN O
+TOM PROPN B-AC
+. PUNCT O
+
+Carriers NOUN O
+were AUX O
+repeatedly ADV O
+outcrossed VERB O
+until SCONJ O
+recombinants NOUN O
+were AUX O
+obtained VERB O
+separating VERB O
+pedigree NOUN O
+M PROPN O
+insertion NOUN O
+03A-0033 NUM O
+, PUNCT O
+in ADP O
+the DET O
+mouse NOUN B-LF
+carbonic ADJ I-LF
+anhydrase NOUN I-LF
+10 NUM I-LF
+gene NOUN I-LF
+( PUNCT O
+Car10 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+pedigree NOUN O
+V NOUN O
+insertion NOUN O
+03A-0063 NUM O
+, PUNCT O
+in ADP O
+the DET O
+mouse NOUN O
+myosin NOUN B-LF
+heavy ADJ I-LF
+chain NOUN I-LF
+2 NUM I-LF
+gene NOUN I-LF
+( PUNCT O
+Myh2 PROPN B-AC
+) PUNCT O
+( PUNCT O
+Table PROPN O
+S1 NOUN O
+) PUNCT O
+, PUNCT O
+from ADP O
+all DET O
+other ADJ O
+insertions NOUN O
+and CCONJ O
+the DET O
+donor NOUN O
+site NOUN O
+( PUNCT O
+unpublished ADJ O
+data NOUN O
+) PUNCT O
+. PUNCT O
+
+First ADV O
+, PUNCT O
+arguments NOUN O
+and CCONJ O
+frames NOUN O
+were AUX O
+developed VERB O
+to PART O
+challenge VERB O
+the DET O
+FCTC PROPN B-AC
+, PUNCT O
+including VERB O
+: PUNCT O
+claiming VERB O
+there PRON O
+would AUX O
+be AUX O
+damaging ADJ O
+economic ADJ O
+consequences NOUN O
+; PUNCT O
+depicting VERB O
+tobacco NOUN O
+control NOUN O
+as ADP O
+an DET O
+agenda NOUN O
+promoted VERB O
+by ADP O
+high ADJ O
+- PUNCT O
+income NOUN O
+countries NOUN O
+; PUNCT O
+alleging VERB O
+the DET O
+treaty NOUN O
+conflicted VERB O
+with ADP O
+trade NOUN O
+agreements NOUN O
+, PUNCT O
+“ PUNCT O
+good ADJ O
+governance NOUN O
+, PUNCT O
+” PUNCT O
+and CCONJ O
+national ADJ O
+sovereignty NOUN O
+; PUNCT O
+questioning VERB O
+WHO PROPN B-AC
+'s PART O
+mandate NOUN O
+; PUNCT O
+claiming VERB O
+the DET O
+FCTC PROPN B-AC
+would AUX O
+set VERB O
+a DET O
+precedent NOUN O
+for ADP O
+issues NOUN O
+beyond ADP O
+tobacco NOUN O
+; PUNCT O
+and CCONJ O
+presenting VERB O
+corporate ADJ B-LF
+social ADJ I-LF
+responsibility NOUN I-LF
+( PUNCT O
+CSR PROPN B-AC
+) PUNCT O
+as ADP O
+an DET O
+alternative NOUN O
+. PUNCT O
+
+Photoactivatable ADJ B-LF
+and CCONJ I-LF
+clickable ADJ I-LF
+sphingosine NOUN I-LF
+( PUNCT O
+pacSph NOUN B-AC
+, PUNCT O
+S1 PROPN O
+Fig PROPN O
+) PUNCT O
+is AUX O
+a DET O
+promising ADJ O
+new ADJ O
+addition NOUN O
+to PART O
+the DET O
+tool NOUN O
+set NOUN O
+, PUNCT O
+as SCONJ O
+it PRON O
+enables VERB O
+to PART O
+specifically ADV O
+crosslink VERB O
+sphingolipids NOUN O
+to PART O
+interacting VERB O
+proteins NOUN O
+via ADP O
+the DET O
+diazirine NOUN O
+group NOUN O
+and CCONJ O
+provides VERB O
+an DET O
+additional ADJ O
+click NOUN O
+functionality NOUN O
+to PART O
+allow VERB O
+for ADP O
+detection NOUN O
+by ADP O
+adding VERB O
+a DET O
+fluorophore NOUN O
+or CCONJ O
+enrichment NOUN O
+by ADP O
+adding VERB O
+a DET O
+tag NOUN O
+for ADP O
+affinity NOUN O
+purification NOUN O
+[ PUNCT O
+11 NUM O
+, PUNCT O
+15 NUM O
+] PUNCT O
+. PUNCT O
+
+UUO PROPN B-AC
+induced VERB O
+monocyte NOUN O
+renal ADJ O
+infiltration NOUN O
+, PUNCT O
+tubular ADJ O
+cell NOUN O
+apoptosis NOUN O
+, PUNCT O
+tubular ADJ O
+atrophy NOUN O
+, PUNCT O
+interstitial ADJ O
+fibrosis NOUN O
+and CCONJ O
+overexpression NOUN O
+of ADP O
+TGFβ NOUN B-AC
+, PUNCT O
+Renin PROPN B-LF
+mRNA NOUN I-LF
+( PUNCT O
+RENmRNA NOUN B-AC
+) PUNCT O
+, PUNCT O
+increase NOUN O
+of ADP O
+Renin PROPN O
+, PUNCT O
+Angiotensin NOUN B-LF
+II NUM I-LF
+( PUNCT O
+AII PROPN B-AC
+) PUNCT O
+and CCONJ O
+aldosterone NOUN O
+serum NOUN O
+levels NOUN O
+. PUNCT O
+
+Among ADP O
+the DET O
+most ADV O
+important ADJ O
+chloroplast NOUN O
+antioxidative ADJ O
+enzymes NOUN O
+are AUX O
+Cu NOUN O
+, PUNCT O
+Zn NOUN O
+- PUNCT O
+superoxide NOUN B-LF
+dismutase NOUN I-LF
+( PUNCT O
+Cu NOUN O
+, PUNCT O
+Zn NOUN O
+- PUNCT O
+SOD PROPN B-AC
+) PUNCT O
+, PUNCT O
+ascorbate NOUN B-LF
+peroxidase NOUN I-LF
+( PUNCT O
+APX PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+glutathione NOUN B-LF
+reductase NOUN I-LF
+( PUNCT O
+GR NOUN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+are AUX O
+frequently ADV O
+complemented VERB O
+with ADP O
+the DET O
+extra ADJ O
+chloroplast NOUN O
+action NOUN O
+of ADP O
+catalase NOUN B-LF
+( PUNCT O
+CAT PROPN B-AC
+) PUNCT O
+, PUNCT O
+when SCONJ O
+H2O2 NOUN B-AC
+diffuses VERB O
+to ADP O
+out ADP O
+of ADP O
+chloroplast NOUN O
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+B. PROPN O
+anthracis PROPN O
+PGN PROPN B-AC
+has VERB O
+a DET O
+stem NOUN O
+peptide NOUN O
+consisting VERB O
+of ADP O
+three NUM O
+amino NOUN O
+acids NOUN O
+including VERB O
+diaminopimelic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+DAP PROPN B-AC
+) PUNCT O
+[ X O
+3 NUM O
+] PUNCT O
+, PUNCT O
+while SCONJ O
+S. PROPN O
+aureus PROPN O
+contains VERB O
+a DET O
+lysine NOUN O
+residue NOUN O
+in ADP O
+the DET O
+DAP PROPN B-AC
+position NOUN O
+and CCONJ O
+has VERB O
+a DET O
+pentapeptide NOUN O
+stem NOUN O
+linked VERB O
+by ADP O
+a DET O
+pentaglycyl NOUN O
+bridge NOUN O
+[ X O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+Compared VERB O
+to PART O
+vaginal ADJ O
+delivery NOUN O
+, PUNCT O
+cesarean ADJ O
+delivery NOUN O
+was AUX O
+associated VERB O
+with ADP O
+decreased VERB O
+risk NOUN O
+of ADP O
+urinary ADJ O
+incontinence NOUN O
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+) PUNCT O
+0.56 NUM O
+( PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+0.47 NUM O
+to PART O
+0.66 NUM O
+; PUNCT O
+n NOUN O
+= SYM O
+58,900 NUM O
+; PUNCT O
+8 NUM O
+studies NOUN O
+) PUNCT O
+and CCONJ O
+pelvic ADJ O
+organ NOUN O
+prolapse NOUN O
+( PUNCT O
+OR NOUN B-AC
+0.29 NUM O
+, PUNCT O
+0.17 NUM O
+to PART O
+0.51 NUM O
+; PUNCT O
+n NOUN O
+= SYM O
+39,208 NUM O
+; PUNCT O
+2 NUM O
+studies NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+term NOUN O
+adaptive ADJ B-LF
+neuro ADJ I-LF
+- ADJ I-LF
+fuzzy ADJ I-LF
+inference NOUN I-LF
+system NOUN I-LF
+( PUNCT O
+ANFIS PROPN B-AC
+) PUNCT O
+was AUX O
+first ADV O
+introduced VERB O
+by ADP O
+Jang PROPN O
+in ADP O
+1993 NUM O
+. PUNCT O
+
+Extracellular ADJ B-LF
+signal NOUN I-LF
+- PUNCT I-LF
+regulated VERB I-LF
+kinase NOUN I-LF
+( PUNCT O
+ERK PROPN B-AC
+) PUNCT O
+stands VERB O
+out ADP O
+as ADP O
+important ADJ O
+positive ADJ O
+[ X O
+2,3][4,5 NUM O
+] X O
+and CCONJ O
+negative ADJ O
+[ X O
+6 X O
+] X O
+regulator NOUN O
+of ADP O
+the DET O
+adipocyte NOUN O
+differentiation NOUN O
+process NOUN O
+. PUNCT O
+
+Sample NOUN O
+size NOUN O
+calculations NOUN O
+for ADP O
+reliability NOUN O
+measures NOUN O
+indicate VERB O
+that SCONJ O
+50–100 NUM O
+persons NOUN O
+are AUX O
+recommended VERB O
+when SCONJ O
+two NUM O
+raters NOUN O
+are AUX O
+used VERB O
+, PUNCT O
+and CCONJ O
+aiming VERB O
+for ADP O
+the DET O
+precision NOUN O
+of ADP O
+CIs NOUN B-AC
+( PUNCT O
+confidence NOUN B-LF
+intervals NOUN I-LF
+) PUNCT O
+of ADP O
++ NOUN O
+/- NOUN O
+0.1 NUM O
+and CCONJ O
+0.2 NUM O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+The DET O
+recent ADJ O
+whole ADJ O
+- PUNCT O
+genome NOUN O
+scan NOUN O
+for ADP O
+breast NOUN O
+cancer NOUN O
+has AUX O
+revealed VERB O
+the DET O
+FGFR2 PROPN B-AC
+( PUNCT O
+fibroblast NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+2 NUM I-LF
+) PUNCT O
+gene NOUN O
+as ADP O
+a DET O
+locus NOUN O
+associated VERB O
+with ADP O
+a DET O
+small ADJ O
+, PUNCT O
+but CCONJ O
+highly ADV O
+significant ADJ O
+, PUNCT O
+increase NOUN O
+in ADP O
+the DET O
+risk NOUN O
+of ADP O
+developing VERB O
+breast NOUN O
+cancer NOUN O
+. PUNCT O
+
+CSP PROPN B-AC
+, PUNCT O
+carotid ADJ B-LF
+sinus NOUN I-LF
+pressure NOUN I-LF
+( PUNCT O
+mmHg NOUN O
+) PUNCT O
+; PUNCT O
+AP NOUN B-AC
+, PUNCT O
+arterial ADJ B-LF
+pressure NOUN I-LF
+( PUNCT O
+mmHg NOUN O
+) PUNCT O
+; PUNCT O
+SNA NOUN B-AC
+, PUNCT O
+sympathetic ADJ B-LF
+nerve NOUN I-LF
+activity NOUN I-LF
+( PUNCT O
+a.u NOUN O
+. PUNCT O
+) PUNCT O
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+bpm NOUN O
+) PUNCT O
+; PUNCT O
+SVR NOUN B-AC
+, PUNCT O
+systemic ADJ B-LF
+vascular ADJ I-LF
+resistance NOUN I-LF
+( PUNCT O
+mmHg•min NOUN O
+/ SYM O
+ml NOUN O
+) PUNCT O
+; PUNCT O
+CO NOUN B-AC
+, PUNCT O
+cardiac ADJ B-LF
+output NOUN I-LF
+( PUNCT O
+ml NOUN O
+/ SYM O
+min NOUN O
+) PUNCT O
+. PUNCT O
+
+On ADP O
+the DET O
+contrary NOUN O
+, PUNCT O
+the DET O
+single ADJ B-LF
+- PUNCT I-LF
+molecule NOUN I-LF
+force NOUN I-LF
+spectroscopy NOUN I-LF
+( PUNCT O
+SMFS PROPN B-AC
+) PUNCT O
+approach NOUN O
+reported VERB O
+here ADV O
+describes VERB O
+, PUNCT O
+by ADP O
+design NOUN O
+, PUNCT O
+the DET O
+conformational ADJ O
+equilibrium NOUN O
+of ADP O
+the DET O
+monomeric ADJ O
+form NOUN O
+. PUNCT O
+
+Relative ADJ O
+kinase NOUN O
+frequencies NOUN O
+across ADP O
+the DET O
+48 NUM O
+species NOUN O
+were AUX O
+calculated VERB O
+for ADP O
+the DET O
+CDK NOUN B-AC
+family NOUN O
+, PUNCT O
+and CCONJ O
+motif NOUN O
+enrichments NOUN O
+were AUX O
+calculated VERB O
+for ADP O
+its PRON O
+cognate ADJ O
+substrate NOUN O
+motif NOUN O
+( PUNCT O
+S NOUN B-AC
+/ SYM B-AC
+T NOUN B-AC
+- PUNCT O
+P NOUN O
+- PUNCT O
+x NOUN O
+- PUNCT O
+K PROPN O
+) PUNCT O
+. PUNCT O
+CDK NOUN B-AC
+, PUNCT O
+Cyclin NOUN B-LF
+- PUNCT I-LF
+Dependent PROPN I-LF
+Kinase PROPN I-LF
+. PUNCT O
+
+For ADP O
+the DET O
+2 NUM O
+COVID-19 PROPN B-AC
+survivors NOUN O
+not PART O
+undergoing VERB O
+cardiac ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+, PUNCT O
+one NUM O
+was AUX O
+implanted VERB O
+with ADP O
+CMR NOUN B-AC
+- PUNCT O
+noncompatible ADJ O
+pacemaker NOUN O
+and CCONJ O
+the DET O
+other ADJ O
+refused VERB O
+to ADP O
+participate VERB O
+due ADP O
+to ADP O
+claustrophobia NOUN O
+. PUNCT O
+
+Total ADJ O
+RNA NOUN O
+from ADP O
+tumor NOUN O
+cells NOUN O
+was AUX O
+isolated VERB O
+by ADP O
+an DET O
+RNA NOUN O
+extraction NOUN O
+kit NOUN O
+( PUNCT O
+Qiagen PROPN O
+) PUNCT O
+and CCONJ O
+cDNA NOUN O
+synthesis NOUN O
+and CCONJ O
+real ADJ O
+- PUNCT O
+time NOUN O
+( PUNCT O
+RT)-PCR NOUN O
+were AUX O
+performed VERB O
+using VERB O
+the DET O
+first ADJ O
+strand NOUN O
+cDNA NOUN O
+synthesis NOUN O
+kit NOUN O
+( PUNCT O
+Fermentas PROPN O
+) PUNCT O
+and CCONJ O
+SYBR PROPN O
+Green PROPN O
+Master PROPN O
+Mix PROPN O
+kit NOUN O
+( PUNCT O
+Roche PROPN O
+) PUNCT O
+applying VERB O
+specific ADJ O
+primers NOUN O
+( PUNCT O
+Life PROPN O
+Technologies PROPN O
+) PUNCT O
+for ADP O
+human ADJ O
+leucine NOUN B-LF
+- PUNCT I-LF
+rich ADJ I-LF
+- PUNCT I-LF
+repeat NOUN I-LF
+- PUNCT I-LF
+containing VERB I-LF
+G NOUN I-LF
+- PUNCT I-LF
+protein NOUN I-LF
+- PUNCT I-LF
+coupled VERB I-LF
+- PUNCT I-LF
+receptor NOUN I-LF
+5 NUM I-LF
+( PUNCT O
+Lgr5 PROPN B-AC
+) PUNCT O
+and CCONJ O
+superoxide NOUN B-LF
+dismutase NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+SOD1 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Face NOUN O
+- VERB O
+to PART O
+- VERB O
+face NOUN O
+interviews NOUN O
+were AUX O
+carried VERB O
+out ADP O
+with ADP O
+the DET O
+heads NOUN O
+of ADP O
+premises NOUN O
+, PUNCT O
+health NOUN O
+leaders NOUN O
+or CCONJ O
+responsible ADJ O
+persons NOUN O
+of ADP O
+pest NOUN O
+control NOUN O
+or CCONJ O
+any DET O
+other ADJ O
+occupant NOUN O
+of ADP O
+the DET O
+premises NOUN O
+who PRON O
+knew VERB O
+about ADP O
+their PRON O
+program NOUN O
+of ADP O
+EFE PROPN B-AC
+. PUNCT O
+The DET O
+interviewers NOUN O
+used VERB O
+a DET O
+pre VERB O
+- VERB O
+tested VERB O
+questionnaire NOUN O
+to PART O
+obtain VERB O
+information NOUN O
+on ADP O
+interviewees NOUN O
+’ PART O
+knowledge NOUN O
+about ADP O
+mosquitoes NOUN O
+[ PUNCT O
+27 NUM O
+] PUNCT O
+, PUNCT O
+mosquito NOUN O
+infestation NOUN O
+in ADP O
+their PRON O
+premises NOUN O
+and CCONJ O
+management NOUN O
+efforts NOUN O
+, PUNCT O
+guidance NOUN O
+and CCONJ O
+supervision NOUN O
+of ADP O
+PHC PROPN B-LF
+System PROPN I-LF
+( PUNCT O
+PHCS PROPN B-AC
+) PUNCT O
+on ADP O
+mosquito NOUN O
+management NOUN O
+. PUNCT O
+
+The DET O
+SID PROPN B-AC
+and CCONJ O
+SEDD PROPN B-AC
+are AUX O
+made VERB O
+available ADJ O
+through ADP O
+the DET O
+Agency PROPN B-LF
+for ADP I-LF
+Healthcare PROPN I-LF
+Research PROPN I-LF
+and CCONJ I-LF
+Quality PROPN I-LF
+’s PART O
+( PUNCT O
+AHRQ PROPN B-AC
+) PUNCT O
+Healthcare PROPN O
+Cost PROPN O
+and CCONJ O
+Utilization PROPN O
+Project PROPN O
+, PUNCT O
+and CCONJ O
+include VERB O
+administrative ADJ O
+claims NOUN O
+data NOUN O
+submitted VERB O
+by ADP O
+all DET O
+participating VERB O
+hospitals NOUN O
+in ADP O
+New PROPN O
+York PROPN O
+State PROPN O
+. PUNCT O
+
+PM2.5 NUM B-AC
+, PUNCT O
+fine ADJ B-LF
+particulate ADJ I-LF
+matter NOUN I-LF
+( PUNCT O
+particulate ADJ O
+matter NOUN O
+with ADP O
+a DET O
+diameter NOUN O
+of ADP O
+< ADP O
+2.5 NUM O
+μm NOUN O
+) PUNCT O
+
+F PROPN B-AC
+- PUNCT B-AC
+BCA PROPN B-AC
+, PUNCT O
+Fsp1 PROPN O
+- PUNCT O
+Cre;Ctnnb1exon PROPN O
+3 NUM O
+fl/+ NOUN O
+; PUNCT O
+FSP1 PROPN B-AC
+, PUNCT O
+fibroblast NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+protein-1 NOUN I-LF
+; PUNCT O
+HE PROPN B-AC
+, PUNCT O
+hematoxylin NOUN B-LF
+– SYM I-LF
+eosin NOUN I-LF
+; PUNCT O
+WAT PROPN B-AC
+, PUNCT O
+white ADJ B-LF
+adipose ADJ I-LF
+tissue NOUN I-LF
+. PUNCT O
+
+The DET O
+clinicopathological ADJ O
+significance NOUN O
+of ADP O
+altered VERB O
+SWI PROPN B-AC
+/ SYM B-AC
+SNF PROPN B-AC
+complex NOUN O
+has AUX O
+not PART O
+been AUX O
+well ADV O
+evaluated VERB O
+in ADP O
+gastric ADJ B-LF
+cancer NOUN I-LF
+( PUNCT O
+GC PROPN B-AC
+) PUNCT O
+. PUNCT O
+We PRON O
+examined VERB O
+SMARCA2 PROPN O
+, PUNCT O
+SMARCA4 PROPN O
+, PUNCT O
+SMARCB1 PROPN O
+and CCONJ O
+ARID1A PROPN O
+expression NOUN O
+by ADP O
+immunohistochemistry NOUN O
+in ADP O
+1224 NUM O
+surgically ADV O
+resected VERB O
+GCs NOUN B-AC
+with ADP O
+subtyping VERB O
+into ADP O
+Epstein PROPN B-LF
+- ADJ I-LF
+Barr PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+EBV PROPN B-AC
+) PUNCT O
+, PUNCT O
+microsatellite NOUN B-LF
+instability NOUN I-LF
+( PUNCT O
+MSI PROPN B-AC
+) PUNCT O
+and CCONJ O
+non ADJ O
+- ADJ O
+EBV PROPN B-AC
+/ SYM O
+MSI PROPN B-AC
+Lauren PROPN O
+histotypes NOUN O
+. PUNCT O
+
+SEEG PROPN B-AC
+, PUNCT O
+stereotactic ADJ B-LF
+electroencephalography NOUN I-LF
+. PUNCT O
+
+It PRON O
+is AUX O
+also ADV O
+the DET O
+only ADJ O
+scoring NOUN O
+system NOUN O
+that PRON O
+takes VERB O
+diffuse ADJ B-LF
+axonal ADJ I-LF
+injury NOUN I-LF
+( PUNCT O
+DAI PROPN B-AC
+) PUNCT O
+visible ADJ O
+on ADP O
+CT PROPN B-AC
+into ADP O
+consideration NOUN O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+
+Ninety NUM O
+- PUNCT O
+six NUM O
+patients NOUN O
+undergoing VERB O
+mechanical ADJ O
+ventilation NOUN O
+in ADP O
+the DET O
+surgical ADJ O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+( PUNCT O
+ICU PROPN B-AC
+) PUNCT O
+were AUX O
+enrolled VERB O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+BD PROPN O
+, PUNCT O
+Becton PROPN O
+Dickinson PROPN O
+; PUNCT O
+BrdU PROPN B-AC
+, PUNCT O
+5 NUM B-LF
+- PUNCT I-LF
+bromodeoxyuridine NOUN I-LF
+; PUNCT O
+Cdc PROPN B-AC
+, PUNCT O
+cell NOUN B-LF
+division NOUN I-LF
+cycle NOUN I-LF
+; PUNCT O
+Cdk PROPN O
+, PUNCT O
+cell NOUN O
+cycle NOUN O
+dependent ADJ O
+kinase NOUN O
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+hMTBP PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+MTBP PROPN I-LF
+; PUNCT O
+IgG PROPN O
+, PUNCT O
+immunoglobulin NOUN O
+; PUNCT O
+Mcm PROPN B-AC
+, PUNCT O
+minichromosome NOUN B-LF
+maintenance NOUN I-LF
+; PUNCT O
+Med PROPN O
+, PUNCT O
+mediator NOUN O
+of ADP O
+transcription NOUN O
+; PUNCT O
+MTBP PROPN B-AC
+, PUNCT O
+Mdm2 NOUN B-LF
+binding VERB I-LF
+protein NOUN I-LF
+; PUNCT O
+Sld PROPN O
+, PUNCT O
+synthetic NOUN O
+lethal ADJ O
+with ADP O
+Dpb11 PROPN B-AC
+; PUNCT O
+TICRR PROPN O
+, PUNCT O
+TopBP1 PROPN B-AC
+interacting VERB O
+checkpoint NOUN O
+and CCONJ O
+replication NOUN O
+regulator NOUN O
+; PUNCT O
+TopBP1 PROPN B-AC
+, PUNCT O
+Topoisomerase NOUN O
+II NUM O
+binding VERB O
+protein NOUN O
+. PUNCT O
+
+BPD NOUN B-AC
+= PUNCT O
+borderline ADJ B-LF
+personality NOUN I-LF
+disorder NOUN I-LF
+, PUNCT O
+SAD NOUN B-AC
+= PUNCT O
+social ADJ B-LF
+anxiety NOUN I-LF
+disorder NOUN I-LF
+/ SYM O
+anxious ADJ O
+avoidant ADJ O
+personality NOUN O
+disorder NOUN O
+, PUNCT O
+HC NOUN B-AC
+= PUNCT O
+healthy ADJ B-LF
+control NOUN I-LF
+participants NOUN I-LF
+, PUNCT O
+DD NOUN B-AC
+= PUNCT O
+current ADJ O
+major ADJ O
+depressive ADJ O
+episode NOUN O
+or CCONJ O
+dysthymia NOUN O
+. PUNCT O
+
+The DET O
+digestion NOUN O
+of ADP O
+AX PROPN B-AC
+using VERB O
+a DET O
+specific ADJ O
+endoxylanase NOUN O
+results VERB O
+in ADP O
+the DET O
+release NOUN O
+of ADP O
+a DET O
+range NOUN O
+of ADP O
+AXOS PROPN B-AC
+, PUNCT O
+the DET O
+total ADJ O
+amount NOUN O
+of ADP O
+which PRON O
+( PUNCT O
+TOTAL PROPN B-LF
+AXOS PROPN I-LF
+) PUNCT O
+reflects VERB O
+the DET O
+content NOUN O
+of ADP O
+total ADJ O
+AX PROPN B-AC
+. PUNCT O
+The DET O
+Aegilops PROPN O
+species NOUN O
+had VERB O
+lower ADJ O
+TOTAL PROPN B-LF
+AXOS PROPN I-LF
+than ADP O
+wheat NOUN O
+during ADP O
+drought NOUN O
+stress NOUN O
+( PUNCT O
+Table PROPN O
+4 NUM O
+) PUNCT O
+, PUNCT O
+as SCONJ O
+also ADV O
+found VERB O
+for ADP O
+the DET O
+TOT PROPN B-AC
+- PUNCT O
+pentosan NOUN O
+content NOUN O
+, PUNCT O
+but CCONJ O
+no DET O
+differences NOUN O
+were AUX O
+observed VERB O
+in ADP O
+the DET O
+TOTAL PROPN B-LF
+AXOS PROPN I-LF
+contents NOUN O
+of ADP O
+the DET O
+addition NOUN O
+lines NOUN O
+( PUNCT O
+Table PROPN O
+3 NUM O
+, PUNCT O
+S4 NUM O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+GPAT2 PROPN O
+knockdown NOUN O
+was AUX O
+routinely ADV O
+assessed VERB O
+by ADP O
+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+PCR NOUN I-LF
+( PUNCT O
+qRT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+) PUNCT O
+[ X O
+8 NUM O
+] X O
+and CCONJ O
+Western ADJ O
+blot NOUN O
+. PUNCT O
+
+The DET O
+accurate ADJ O
+detection NOUN O
+of ADP O
+severe ADJ B-LF
+acute ADJ I-LF
+respiratory ADJ I-LF
+syndrome NOUN I-LF
+– PUNCT I-LF
+coronavirus NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+) PUNCT O
+is AUX O
+essential ADJ O
+for ADP O
+the DET O
+diagnosis NOUN O
+of ADP O
+coronavirus NOUN B-LF
+disease NOUN I-LF
+2019 NUM I-LF
+( PUNCT O
+COVID-19 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+E10.5 NUM B-AC
+, PUNCT O
+embryonic ADJ B-LF
+day NOUN I-LF
+10.5 NUM I-LF
+; PUNCT O
+E11.5 NUM B-AC
+, PUNCT O
+embryonic ADJ B-LF
+day NOUN I-LF
+11.5 NUM I-LF
+; PUNCT O
+E12.5 NUM B-AC
+, PUNCT O
+embryonic ADJ B-LF
+day NOUN I-LF
+12.5 NUM I-LF
+; PUNCT O
+EP PROPN O
+, PUNCT O
+embryo NOUN O
+proper ADJ O
+; PUNCT O
+IF PROPN B-AC
+, PUNCT O
+immunofluorescence NOUN B-LF
+; PUNCT O
+PECAM PROPN O
+, PUNCT O
+platelet NOUN O
+endothelial ADJ O
+cell NOUN O
+adhesion NOUN O
+molecule NOUN O
+; PUNCT O
+p NOUN O
+- PUNCT O
+RIPK3 NOUN O
+, PUNCT O
+phosphorylated VERB O
+RIPK3 NOUN O
+; PUNCT O
+RIPK1 PROPN B-AC
+, PUNCT O
+receptor NOUN B-LF
+interacting VERB I-LF
+serine NOUN I-LF
+/ SYM I-LF
+threonine NOUN I-LF
+kinase NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+YS PROPN O
+, PUNCT O
+yolk NOUN O
+sac NOUN O
+. PUNCT O
+
+CaM PROPN B-AC
+, PUNCT O
+calmodulin NOUN B-LF
+; PUNCT O
+HDX NOUN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+, PUNCT O
+hydrogen NOUN B-LF
+/ SYM I-LF
+deuterium NOUN I-LF
+exchange NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+. PUNCT O
+
+The DET O
+most ADV O
+recent ADJ O
+data NOUN O
+collected VERB O
+during ADP O
+the DET O
+Demographic PROPN B-LF
+and CCONJ I-LF
+Health PROPN I-LF
+Surveys PROPN I-LF
+( PUNCT O
+DHS PROPN B-AC
+) PUNCT O
+conducted VERB O
+between ADP O
+2010 NUM O
+and CCONJ O
+2018 NUM O
+in ADP O
+African ADJ O
+countries NOUN O
+was AUX O
+used VERB O
+. PUNCT O
+
+Feedback NOUN O
+pathways NOUN O
+involving VERB O
+enzymes NOUN O
+such ADJ O
+as ADP O
+riboflavin NOUN O
+kinase NOUN O
+( PUNCT O
+EC PROPN O
+2.7.1.26 NUM O
+) PUNCT O
+and CCONJ O
+FAD PROPN B-AC
+( PUNCT O
+flavin NOUN B-LF
+adenine NOUN I-LF
+dinucleotide NOUN I-LF
+) PUNCT O
+diphosphatase NOUN O
+( PUNCT O
+EC PROPN O
+3.6.1.18 NUM O
+) PUNCT O
+probably ADV O
+regulate VERB O
+intracellular ADJ O
+FMN PROPN B-AC
+to PART O
+titrate VERB O
+endogenous ADJ O
+flavoproteins NOUN O
+and CCONJ O
+miniSOG NOUN B-AC
+[ PUNCT O
+25 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+MAbs NOUN B-AC
+2F5 NUM O
+and CCONJ O
+4E10 PROPN O
+, PUNCT O
+which PRON O
+target VERB O
+conserved VERB O
+epitopes NOUN O
+within ADP O
+the DET O
+membrane NOUN B-LF
+- PUNCT I-LF
+proximal ADJ I-LF
+external ADJ I-LF
+region NOUN I-LF
+( PUNCT O
+MPER PROPN B-AC
+) PUNCT O
+of ADP O
+gp41 NOUN O
+, PUNCT O
+are AUX O
+unusually ADV O
+hydrophobic ADJ O
+and CCONJ O
+may AUX O
+even ADV O
+be AUX O
+autoreactive ADJ O
+[ PUNCT O
+12,13 NUM O
+] PUNCT O
+. PUNCT O
+
+Three NUM O
+classes NOUN O
+of ADP O
+protocols NOUN O
+for ADP O
+DR PROPN B-AC
+have AUX O
+been AUX O
+used VERB O
+to PART O
+extend VERB O
+lifespan NOUN O
+in ADP O
+C. PROPN O
+elegans NOUN O
+: PUNCT O
+“ PUNCT O
+axenic ADJ O
+” PUNCT O
+or CCONJ O
+“ PUNCT O
+dietary ADJ O
+deprivation NOUN O
+” PUNCT O
+dietary ADJ B-LF
+restriction NOUN I-LF
+with ADP O
+no DET O
+bacteria NOUN O
+[ PUNCT O
+16],[17],[5 NUM O
+. PUNCT O
+] PUNCT O
+, PUNCT O
+genetic ADJ O
+reduction NOUN O
+of ADP O
+feeding NOUN O
+rate NOUN O
+( PUNCT O
+e.g. X O
+, PUNCT O
+by ADP O
+mutation NOUN O
+in ADP O
+the DET O
+eat-2 NOUN O
+gene NOUN O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+optimized VERB O
+bacterial ADJ O
+dilution NOUN O
+in ADP O
+liquid NOUN O
+media NOUN O
+( PUNCT O
+bDR PROPN B-AC
+) PUNCT O
+[ PUNCT O
+19],[3],[8 NUM O
+] PUNCT O
+. PUNCT O
+
+RNA2 NOUN O
+also ADV O
+encodes VERB O
+protein NOUN O
+2b NUM O
+, PUNCT O
+in ADP O
+a DET O
+second ADJ O
+open ADJ B-LF
+reading NOUN I-LF
+frame NOUN I-LF
+( PUNCT O
+ORF PROPN B-AC
+) PUNCT O
+overlapping VERB O
+that PRON O
+for ADP O
+protein NOUN O
+2a NUM O
+, PUNCT O
+which PRON O
+is AUX O
+a DET O
+suppressor NOUN O
+of ADP O
+the DET O
+post ADJ O
+- PUNCT O
+transcriptional ADJ O
+gene NOUN O
+- PUNCT O
+silencing VERB O
+defense NOUN O
+of ADP O
+the DET O
+host NOUN O
+plant NOUN O
+. PUNCT O
+
+In ADP O
+the DET O
+presence NOUN O
+of ADP O
+Nrf2 PROPN B-AC
+activators NOUN O
+( PUNCT O
+oxidative ADJ O
+stress NOUN O
+, PUNCT O
+some DET O
+chemicals NOUN O
+including VERB O
+phytochemicals NOUN O
+) PUNCT O
+, PUNCT O
+the DET O
+Nrf2 PROPN B-AC
+dissociates VERB O
+from ADP O
+Keap1 PROPN O
+and CCONJ O
+translocates VERB O
+in ADP O
+to ADP O
+the DET O
+nucleus NOUN O
+where SCONJ O
+it PRON O
+assembles VERB O
+to ADP O
+a DET O
+cis ADJ O
+- PUNCT O
+acting VERB O
+regulatory ADJ O
+sequences NOUN O
+called VERB O
+antioxidant ADJ O
+response NOUN O
+element NOUN O
+( PUNCT O
+ARE PROPN O
+) PUNCT O
+or CCONJ O
+electrophile ADJ B-LF
+- PUNCT I-LF
+response NOUN I-LF
+element NOUN I-LF
+( PUNCT O
+EpRE PROPN B-AC
+) PUNCT O
+, PUNCT O
+located VERB O
+in ADP O
+the DET O
+promoter NOUN O
+region NOUN O
+of ADP O
+genes NOUN O
+encoding VERB O
+various ADJ O
+antioxidant ADJ O
+and CCONJ O
+phase NOUN O
+2 NUM O
+detoxifying VERB O
+enzymes NOUN O
+and CCONJ O
+resulting VERB O
+in ADP O
+their PRON O
+expression NOUN O
+[ PUNCT O
+8,10 NUM O
+] PUNCT O
+. PUNCT O
+
+Open ADJ O
+transforaminal ADJ B-LF
+lumbar NOUN I-LF
+interbody NOUN I-LF
+fusion NOUN I-LF
+( PUNCT O
+TLIF PROPN B-AC
+) PUNCT O
+and CCONJ O
+posterior ADJ B-LF
+lumbar NOUN I-LF
+interbody NOUN I-LF
+fusion NOUN I-LF
+( PUNCT O
+PLIF PROPN B-AC
+) PUNCT O
+are AUX O
+two NUM O
+widely ADV O
+used VERB O
+techniques NOUN O
+for ADP O
+spinal ADJ O
+fusion NOUN O
+. PUNCT O
+
+To PART O
+generate VERB O
+a DET O
+comprehensive ADJ O
+, PUNCT O
+deeply ADV O
+sampled VERB O
+C. PROPN O
+elegans PROPN O
+proteome NOUN O
+database NOUN O
+that PRON O
+can AUX O
+be AUX O
+used VERB O
+for ADP O
+quantitative ADJ O
+proteome NOUN O
+analysis NOUN O
+, PUNCT O
+we PRON O
+applied VERB O
+subcellular ADJ O
+and CCONJ O
+biochemical ADJ O
+fractionation NOUN O
+methods NOUN O
+to ADP O
+the DET O
+worm NOUN O
+proteins NOUN O
+, PUNCT O
+performed VERB O
+tryptic NOUN O
+digests NOUN O
+, PUNCT O
+separated VERB O
+the DET O
+resulting VERB O
+peptides NOUN O
+using VERB O
+a DET O
+variety NOUN O
+of ADP O
+techniques NOUN O
+, PUNCT O
+and CCONJ O
+identified VERB O
+the DET O
+peptides NOUN O
+by ADP O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+( PUNCT O
+MS NOUN B-AC
+) PUNCT O
+. PUNCT O
+This PRON O
+resulted VERB O
+in ADP O
+a DET O
+unique ADJ O
+global ADJ O
+view NOUN O
+on ADP O
+the DET O
+expression NOUN O
+status NOUN O
+of ADP O
+the DET O
+C. PROPN O
+elegans PROPN O
+proteome NOUN O
+. PUNCT O
+
+To ADP O
+our PRON O
+knowledge NOUN O
+, PUNCT O
+this DET O
+study NOUN O
+is AUX O
+the DET O
+first ADJ O
+to ADP O
+apply VERB O
+a DET O
+multistage NOUN O
+sampling NOUN O
+- PUNCT O
+based VERB O
+approach NOUN O
+to ADP O
+generating VERB O
+provincially ADV O
+representative ADJ O
+mortality NOUN O
+rates NOUN O
+for ADP O
+HIV PROPN O
+programs NOUN O
+in ADP O
+low- ADJ B-LF
+and CCONJ I-LF
+middle ADJ I-LF
+- PUNCT I-LF
+income NOUN I-LF
+countries NOUN I-LF
+( PUNCT O
+LMICs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+GLP-1R NOUN B-AC
+, PUNCT O
+glucagon NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+peptide-1 NOUN I-LF
+receptor NOUN I-LF
+. PUNCT O
+
+Educational ADJ O
+attainment NOUN O
+was AUX O
+also ADV O
+defined VERB O
+by ADP O
+asking VERB O
+“ PUNCT O
+Which PRON O
+of ADP O
+the DET O
+following ADJ O
+qualifications NOUN O
+do AUX O
+you PRON O
+have VERB O
+? PUNCT O
+” PUNCT O
+for ADP O
+which PRON O
+participants NOUN O
+could AUX O
+select VERB O
+more ADJ O
+than ADP O
+one NUM O
+option NOUN O
+, PUNCT O
+including VERB O
+“ PUNCT O
+College PROPN O
+or CCONJ O
+University PROPN O
+degree NOUN O
+, PUNCT O
+” PUNCT O
+“ PUNCT O
+A NOUN O
+levels NOUN O
+/ SYM O
+AS PROPN O
+levels NOUN O
+or CCONJ O
+equivalent NOUN O
+, PUNCT O
+” PUNCT O
+“ PUNCT O
+O PROPN O
+levels NOUN O
+/ SYM O
+GCSEs NOUN B-AC
+or CCONJ O
+equivalent NOUN O
+, PUNCT O
+” PUNCT O
+“ PUNCT O
+CESs NOUN O
+or CCONJ O
+equivalent NOUN O
+, PUNCT O
+” PUNCT O
+“ PUNCT O
+NVQ PROPN O
+or CCONJ O
+HND PROPN O
+or CCONJ O
+HNC PROPN O
+or CCONJ O
+equivalent NOUN O
+, PUNCT O
+” PUNCT O
+“ PUNCT O
+Other ADJ O
+professional ADJ O
+qualifications NOUN O
+, PUNCT O
+e.g. X O
+, PUNCT O
+nursing NOUN O
+, PUNCT O
+teaching NOUN O
+, PUNCT O
+” PUNCT O
+or CCONJ O
+“ PUNCT O
+None PROPN O
+of ADP O
+the DET O
+above ADJ O
+. PUNCT O
+” PUNCT O
+Participant NOUN O
+responses NOUN O
+were AUX O
+coded VERB O
+into ADP O
+categorical ADJ O
+variables NOUN O
+for ADP O
+degree NOUN O
+holders NOUN O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+for ADP O
+those PRON O
+who PRON O
+had AUX O
+completed VERB O
+advanced ADJ O
+- PUNCT O
+level NOUN O
+studies NOUN O
+( PUNCT O
+A NOUN O
+- PUNCT O
+level NOUN O
+) PUNCT O
+or CCONJ O
+had AUX O
+obtained VERB O
+their PRON O
+general ADJ B-LF
+certificate NOUN I-LF
+of ADP I-LF
+secondary ADJ I-LF
+education NOUN I-LF
+( PUNCT O
+GCSE PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+The DET O
+underlying VERB O
+data NOUN O
+for ADP O
+this DET O
+figure NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+cko NOUN B-AC
+, PUNCT O
+conditional ADJ B-LF
+knockout NOUN I-LF
+; PUNCT O
+HSA PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+alpha NOUN I-LF
+- PUNCT I-LF
+skeletal ADJ I-LF
+actin NOUN I-LF
+; PUNCT O
+IL PROPN B-AC
+, PUNCT O
+interleukin NOUN B-LF
+; PUNCT O
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+Lmna PROPN O
+, PUNCT O
+lamin NOUN O
+A PROPN O
+/ SYM O
+C PROPN O
+gene NOUN O
+; PUNCT O
+LmnaHSA PROPN B-AC
+- PUNCT B-AC
+cko NOUN B-AC
+, PUNCT O
+skeletal ADJ B-LF
+muscle NOUN I-LF
+– PUNCT I-LF
+specific ADJ I-LF
+Lmna PROPN I-LF
+- PUNCT I-LF
+cko NOUN I-LF
+mice NOUN I-LF
+; PUNCT O
+mo PROPN B-AC
+, PUNCT O
+months NOUN B-LF
+old ADJ I-LF
+. PUNCT O
+
+We PRON O
+applied VERB O
+CFA PROPN B-AC
+, PUNCT O
+bifactor ADJ O
+CFA PROPN B-AC
+, PUNCT O
+exploratory ADJ B-LF
+structural ADJ I-LF
+equation NOUN I-LF
+modeling NOUN I-LF
+( PUNCT O
+ESEM PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+bifactor ADJ O
+ESEM PROPN B-AC
+to ADP O
+the DET O
+AFM-2 PROPN B-AC
+( PUNCT O
+Study NOUN O
+1 NUM O
+) PUNCT O
+, PUNCT O
+ATQ PROPN B-AC
+- PUNCT B-AC
+P PROPN B-AC
+( PUNCT O
+Study NOUN O
+2 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+PHQ-9 PROPN B-AC
+( PUNCT O
+Study NOUN O
+4 NUM O
+) PUNCT O
+. PUNCT O
+
+NTBC PROPN B-AC
+, PUNCT O
+nitisinone PROPN B-LF
+. PUNCT O
+
+The DET O
+gross ADJ O
+pictures NOUN O
+of ADP O
+the DET O
+aorta NOUN O
+after ADP O
+laparotomy NOUN O
+at ADP O
+day-28 NUM O
+explant NOUN O
+showed VERB O
+increased VERB O
+external ADJ O
+diameter NOUN O
+and CCONJ O
+significant ADJ O
+inflammation NOUN O
+in ADP O
+the DET O
+PPE PROPN O
+group NOUN O
+( PUNCT O
+Fig NOUN O
+4A NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+outer ADJ O
+diameter NOUN O
+of ADP O
+the DET O
+aneurysmal ADJ O
+aortas NOUN O
+increased VERB O
+significantly ADV O
+above ADP O
+~ NUM O
+95 NUM O
+% NOUN O
+at ADP O
+day-14 NUM O
+and CCONJ O
+up ADP O
+to ADP O
+~200 NUM O
+% NOUN O
+at ADP O
+day-28 NUM O
+in ADP O
+the DET O
+PPE PROPN O
+treated VERB O
+mice NOUN O
+( PUNCT O
+Fig NOUN O
+4B NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+histology NOUN O
+at ADP O
+14 NUM O
+- PUNCT O
+day NOUN O
+explant NOUN O
+confirmed VERB O
+aneurysmal ADJ O
+expansion NOUN O
+and CCONJ O
+significantly ADV O
+degraded VERB O
+elastic ADJ O
+lamina NOUN O
+in ADP O
+PPE PROPN O
+treated VERB O
+group NOUN O
+( PUNCT O
+Fig NOUN O
+4C NUM O
+) PUNCT O
+. PUNCT O
+While SCONJ O
+external ADJ O
+diameter NOUN O
+continued VERB O
+to ADP O
+increase VERB O
+in ADP O
+untreated ADJ O
+group NOUN O
+, PUNCT O
+in ADP O
+EL PROPN B-AC
+- PUNCT B-AC
+PGG PROPN B-AC
+- PUNCT B-AC
+NPs PROPN B-AC
+group NOUN O
+, PUNCT O
+the DET O
+external ADJ O
+diameter NOUN O
+significantly ADV O
+decreased VERB O
+below ADP O
+~ NUM O
+45 NUM O
+% NOUN O
+in ADP O
+comparison NOUN O
+to ADP O
+PPE PROPN O
+treated VERB O
+group NOUN O
+at ADP O
+day-28 NUM O
+( PUNCT O
+Fig NOUN O
+4B NUM O
+) PUNCT O
+. PUNCT O
+These DET O
+data NOUN O
+suggest VERB O
+that SCONJ O
+site NOUN O
+- PUNCT O
+specific ADJ O
+delivery NOUN O
+of ADP O
+PGG PROPN B-AC
+with ADP O
+nanoparticles NOUN B-LF
+reverses VERB O
+already ADV O
+developed VERB O
+aneurysm NOUN O
+and CCONJ O
+restores VERB O
+arterial ADJ O
+mechanics NOUN O
+[ PUNCT O
+12–15 NUM O
+] PUNCT O
+. PUNCT O
+
+ACh NOUN B-AC
+: PUNCT O
+acetylcholine NOUN B-LF
+, PUNCT O
+BMM NOUN B-AC
+: PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+- PUNCT I-LF
+derived VERB I-LF
+macrophage NOUN I-LF
+, PUNCT O
+CIA NOUN B-AC
+: PUNCT O
+collagen NOUN B-LF
+- PUNCT I-LF
+induced VERB I-LF
+arthritis NOUN I-LF
+, PUNCT O
+NA NOUN B-AC
+: PUNCT O
+noradrenaline NOUN B-LF
+, PUNCT O
+SEM NOUN B-AC
+: PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+, PUNCT O
+p.i NOUN O
+. PUNCT O
+: PUNCT O
+post NOUN O
+- PUNCT O
+immunization NOUN O
+, PUNCT O
+TRAP NOUN B-AC
+: PUNCT O
+tartrate NOUN B-LF
+- PUNCT I-LF
+resistant ADJ I-LF
+acid NOUN I-LF
+phosphatase NOUN I-LF
+
+AZT PROPN B-AC
+, PUNCT O
+azidothymidine NOUN B-LF
+; PUNCT O
+BPS PROPN O
+, PUNCT O
+iron NOUN O
+starvation NOUN O
+- PUNCT O
+FeSO NOUN O
+; PUNCT O
+CCCP PROPN O
+, PUNCT O
+Carbonyl NOUN O
+cyanide NOUN O
+3 NUM O
+- PUNCT O
+chlorophenylhydrazone NOUN O
+; PUNCT O
+EGCG PROPN O
+, PUNCT O
+epigallocatechin NOUN O
+gallate NOUN O
+; PUNCT O
+MDR PROPN B-AC
+, PUNCT O
+multidrug NOUN B-LF
+- PUNCT I-LF
+resistant ADJ I-LF
+; PUNCT O
+MIC PROPN B-AC
+, PUNCT O
+minimum ADJ B-LF
+inhibitory ADJ I-LF
+concentration NOUN I-LF
+; PUNCT O
+MMS PROPN O
+, PUNCT O
+methyl NOUN O
+methanesulfonate NOUN O
+; PUNCT O
+PMS PROPN O
+, PUNCT O
+phenazine NOUN O
+methosulfate NOUN O
+
+Therefore ADV O
+, PUNCT O
+the DET O
+aim NOUN O
+of ADP O
+this DET O
+study NOUN O
+was AUX O
+to PART O
+research VERB O
+the DET O
+antitumor ADJ O
+effects NOUN O
+of ADP O
+the DET O
+ginsenoside NOUN B-LF
+Rk3 PROPN I-LF
+on ADP O
+esophageal ADJ O
+cancer NOUN O
+cell NOUN O
+lines NOUN O
+and CCONJ O
+to PART O
+investigate VERB O
+the DET O
+potential ADJ O
+molecular ADJ O
+mechanisms NOUN O
+by ADP O
+which PRON O
+it PRON O
+activates VERB O
+apoptosis NOUN O
+and CCONJ O
+autophagy NOUN O
+both CCONJ O
+in ADP O
+vitro ADJ O
+and CCONJ O
+in ADP O
+vivo ADJ O
+. PUNCT O
+
+The DET O
+6 NUM O
+immune NOUN O
+- PUNCT O
+mediated VERB O
+diseases NOUN O
+are AUX O
+Crohn PROPN B-LF
+disease NOUN I-LF
+( PUNCT O
+CD PROPN B-AC
+) PUNCT O
+, PUNCT O
+ulcerative ADJ B-LF
+colitis NOUN I-LF
+( PUNCT O
+UC PROPN B-AC
+) PUNCT O
+, PUNCT O
+type NOUN B-LF
+1 NUM I-LF
+diabetes NOUN I-LF
+( PUNCT O
+T1D PROPN B-AC
+) PUNCT O
+, PUNCT O
+rheumatoid ADJ B-LF
+arthritis NOUN I-LF
+( PUNCT O
+RA PROPN B-AC
+) PUNCT O
+, PUNCT O
+celiac ADJ B-LF
+disease NOUN I-LF
+( PUNCT O
+CeD PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+psoriasis NOUN O
+( PUNCT O
+PSOR PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+levels NOUN O
+of ADP O
+−log10(p NOUN O
+) PUNCT O
+> SYM O
+0 NUM O
+, PUNCT O
+−log10(p NOUN O
+) PUNCT O
+> SYM O
+1 NUM O
+, PUNCT O
+and CCONJ O
+−log10(p NOUN O
+) PUNCT O
+> SYM O
+2 NUM O
+correspond VERB O
+to ADP O
+p NOUN O
+< SYM O
+1 NUM O
+, PUNCT O
+p NOUN O
+< SYM O
+0.1 NUM O
+, PUNCT O
+and CCONJ O
+p NOUN O
+< SYM O
+0.01 NUM O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+Apc PROPN B-AC
+, PUNCT O
+adenomatous ADJ O
+polyposis NOUN O
+coli NOUN O
+; PUNCT O
+IL-22 NOUN B-AC
+, PUNCT O
+interleukin-22 NOUN B-LF
+; PUNCT O
+pSTAT3 NOUN B-AC
+, PUNCT O
+phosphorylated VERB B-LF
+STAT3 PROPN I-LF
+; PUNCT O
+STAT3 PROPN B-AC
+, PUNCT O
+signal NOUN B-LF
+transducer NOUN I-LF
+and CCONJ I-LF
+activator NOUN I-LF
+of ADP I-LF
+transcription NOUN I-LF
+3 NUM I-LF
+; PUNCT O
+Tyr705 PROPN O
+, PUNCT O
+Tyrosine PROPN O
+705 NUM O
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Although SCONJ O
+WHO PROPN O
+recommends VERB O
+viral ADJ B-LF
+load NOUN I-LF
+( PUNCT O
+VL PROPN B-AC
+) PUNCT O
+monitoring NOUN O
+for ADP O
+those PRON O
+on ADP O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+( PUNCT O
+ART PROPN B-AC
+) PUNCT O
+, PUNCT O
+availability NOUN O
+in ADP O
+low ADJ O
+- PUNCT O
+income NOUN O
+countries NOUN O
+remains VERB O
+limited ADJ O
+. PUNCT O
+
+( PUNCT O
+A PRON O
+) PUNCT O
+A PRON O
+drift NOUN O
+- PUNCT O
+corrected VERB O
+cryo NOUN B-AC
+- PUNCT B-AC
+EM PROPN B-AC
+micrograph NOUN O
+of ADP O
+the DET O
+dOrai PROPN B-AC
+- PUNCT O
+P288L PROPN O
+channel NOUN O
+. PUNCT O
+( PUNCT O
+B NOUN O
+) PUNCT O
+Ctffind PROPN O
+showed VERB O
+Thon NOUN O
+rings NOUN O
+in ADP O
+the DET O
+Fourier PROPN O
+spectrum NOUN O
+of ADP O
+the DET O
+image NOUN O
+in ADP O
+panel NOUN O
+A. PUNCT O
+( PUNCT O
+C NOUN O
+) PUNCT O
+Selected VERB O
+two NUM O
+- PUNCT O
+dimensional ADJ O
+class NOUN O
+averages NOUN O
+of ADP O
+the DET O
+dOrai PROPN B-AC
+- PUNCT O
+P288L PROPN O
+channel NOUN O
+. PUNCT O
+( PUNCT O
+D NOUN O
+) PUNCT O
+The DET O
+gold ADJ O
+- PUNCT O
+standard NOUN O
+FSC PROPN O
+coefficient NOUN O
+curve NOUN O
+of ADP O
+the DET O
+final ADJ O
+reconstruction NOUN O
+showed VERB O
+an DET O
+overall ADJ O
+resolution NOUN O
+of ADP O
+5.7 NUM O
+Å. PUNCT O
+( PUNCT O
+E NOUN O
+) PUNCT O
+Local ADJ O
+resolution NOUN O
+estimation NOUN O
+by ADP O
+ResMap PROPN O
+( PUNCT O
+http://resmap.sourceforge.net/ X O
+) PUNCT O
+. PUNCT O
+cryo NOUN B-AC
+- PUNCT B-AC
+EM PROPN B-AC
+, PUNCT O
+cryo NOUN O
+- PUNCT O
+electron NOUN O
+microscopy NOUN O
+; PUNCT O
+dOrai PROPN B-AC
+, PUNCT O
+Drosophila PROPN B-LF
+melanogaster NOUN I-LF
+Orai PROPN I-LF
+; PUNCT O
+FSC PROPN O
+, PUNCT O
+Fourier PROPN O
+shell NOUN O
+correlation NOUN O
+. PUNCT O
+
+AH NOUN B-AC
+– PUNCT O
+arterial ADJ B-LF
+hypertension NOUN I-LF
+, PUNCT O
+BA PROPN B-AC
+– PUNCT O
+bronchial NOUN B-LF
+asthma NOUN I-LF
+, PUNCT O
+CK NOUN B-AC
+– PUNCT O
+creatine NOUN B-LF
+kinase NOUN I-LF
+, PUNCT O
+CHD PROPN B-AC
+– PUNCT O
+coronary ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+, PUNCT O
+CHF PROPN B-AC
+- NOUN O
+congestive ADJ B-LF
+heart NOUN I-LF
+failure NOUN I-LF
+, PUNCT O
+CKD PROPN B-AC
+– PUNCT O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+, PUNCT O
+CRP- PROPN B-AC
+C NOUN B-LF
+- NOUN I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+, PUNCT O
+CT PROPN B-AC
+computer NOUN B-LF
+tomography NOUN I-LF
+, PUNCT O
+DBP PROPN B-AC
+– PUNCT O
+diastolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+, PUNCT O
+DM PROPN B-AC
+– PUNCT O
+Diabetes PROPN B-LF
+Mellitus PROPN I-LF
+type NOUN I-LF
+2 NUM I-LF
+, PUNCT O
+ESR PROPN B-AC
+– PUNCT O
+erythrocytes NOUN B-LF
+sedimentation NOUN I-LF
+rate NOUN I-LF
+, PUNCT O
+Hb NOUN B-AC
+– PUNCT O
+hemoglobin NOUN B-LF
+, PUNCT O
+HR NOUN B-AC
+– PUNCT O
+heart NOUN B-LF
+rate NOUN I-LF
+, PUNCT O
+MI PROPN B-AC
+– PUNCT O
+myocardial NOUN B-LF
+infarction NOUN I-LF
+, PUNCT O
+SBP PROPN B-AC
+– PUNCT O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+, PUNCT O
+WBC PROPN B-AC
+– PUNCT O
+white NOUN B-LF
+blood NOUN I-LF
+count NOUN I-LF
+. PUNCT O
+
+Underlying VERB O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+at ADP O
+https://osf.io/cbjq6/. X O
+fMRI NOUN B-AC
+, PUNCT O
+functional ADJ B-LF
+MRI NOUN I-LF
+; PUNCT O
+EVC PROPN B-AC
+, PUNCT O
+early ADJ B-LF
+visual ADJ I-LF
+cortex NOUN I-LF
+; PUNCT O
+std NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+D PROPN B-AC
+- PUNCT B-AC
+dimer NOUN B-AC
+, PUNCT O
+Dimerized VERB B-LF
+plasmin NOUN I-LF
+fragment NOUN I-LF
+D PROPN I-LF
+; PUNCT O
+CRP PROPN B-AC
+, PUNCT O
+C NOUN B-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+PCT PROPN B-AC
+, PUNCT O
+procalcitonin NOUN B-LF
+; PUNCT O
+LDH PROPN B-AC
+, PUNCT O
+lactate NOUN B-LF
+dehydrogenase NOUN I-LF
+; PUNCT O
+WBC PROPN B-AC
+, PUNCT O
+white ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+CK PROPN B-AC
+, PUNCT O
+creatinine NOUN B-LF
+kinase NOUN I-LF
+; PUNCT O
+AST PROPN B-AC
+, PUNCT O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+; PUNCT O
+CI NOUN O
+, PUNCT O
+confidential ADJ O
+interval NOUN O
+. PUNCT O
+
+Hazard NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+HRs NOUN B-AC
+) PUNCT O
+with ADP O
+95 NUM O
+% NOUN O
+CIs NOUN O
+were AUX O
+estimated VERB O
+using VERB O
+multivariable ADJ O
+Cox PROPN O
+regression NOUN O
+to PART O
+examine VERB O
+mortality NOUN O
+during ADP O
+the DET O
+study NOUN O
+period NOUN O
+. PUNCT O
+
+In ADP O
+line NOUN O
+with ADP O
+this DET O
+observation NOUN O
+, PUNCT O
+we PRON O
+found VERB O
+that SCONJ O
+simultaneous ADJ O
+inhibition NOUN O
+of ADP O
+the DET O
+2 NUM O
+major ADJ O
+receptors NOUN O
+of ADP O
+PGE2 PROPN B-AC
+— PUNCT O
+prostaglandin NOUN B-LF
+E2 PROPN I-LF
+receptor NOUN O
+2 NUM O
+( PUNCT O
+EP2 PROPN O
+) PUNCT O
+and CCONJ O
+EP4 PROPN O
+— PUNCT O
+on ADP O
+moDCs NOUN B-AC
+reduced VERB O
+the DET O
+ability NOUN O
+of ADP O
+SEAΔα-1 NOUN O
+/ SYM O
+ω-1 NOUN B-AC
+– PUNCT O
+stimulated VERB O
+moDCs NOUN B-AC
+to PART O
+induce VERB O
+a DET O
+Th2 NOUN B-AC
+response NOUN O
+( PUNCT O
+Fig PROPN O
+2C NUM O
+) PUNCT O
+. PUNCT O
+These DET O
+results NOUN O
+collectively ADV O
+demonstrate VERB O
+that SCONJ O
+SEA PROPN B-AC
+, PUNCT O
+independently ADV O
+of ADP O
+ω-1 NOUN B-AC
+, PUNCT O
+promotes VERB O
+PGE2 PROPN B-AC
+synthesis NOUN O
+by ADP O
+moDCs NOUN B-AC
+, PUNCT O
+which PRON O
+subsequently ADV O
+, PUNCT O
+in ADP O
+an DET O
+autocrine ADJ O
+manner NOUN O
+, PUNCT O
+conditions VERB O
+these DET O
+cells NOUN O
+to PART O
+acquire VERB O
+a DET O
+Th2 NOUN B-AC
+- PUNCT O
+polarizing VERB O
+phenotype NOUN O
+. PUNCT O
+
+SD PROPN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+; PUNCT O
+BCS PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+condition NOUN I-LF
+score NOUN I-LF
+; PUNCT O
+BOAS PROPN B-AC
+, PUNCT O
+brachycephalic ADJ B-LF
+obstructive ADJ I-LF
+airway NOUN I-LF
+syndrome NOUN I-LF
+; PUNCT O
+NA PROPN O
+, PUNCT O
+data NOUN O
+not PART O
+available ADJ O
+. PUNCT O
+
+The DET O
+nuclear ADJ O
+signal NOUN O
+obtained VERB O
+from ADP O
+the DET B-AC
+resulting VERB O
+image NOUN O
+was AUX O
+measured VERB O
+to PART O
+obtain VERB O
+the DET B-AC
+raw ADJ B-LF
+integrated VERB I-LF
+density NOUN I-LF
+( PUNCT O
+RID NOUN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+nuclear ADJ O
+area NOUN O
+was AUX O
+obtained VERB O
+from ADP O
+the DET B-AC
+mask NOUN O
+. PUNCT O
+
+Several ADJ O
+markers NOUN O
+have AUX O
+been AUX O
+individually ADV O
+used VERB O
+to PART O
+identify VERB O
+CMs PROPN B-AC
+( PUNCT O
+signal ADJ B-LF
+regulatory ADJ I-LF
+protein NOUN I-LF
+alpha NOUN I-LF
+[ X O
+SIRPα PROPN B-AC
+] PUNCT O
+, PUNCT O
+vascular ADJ B-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+1 NUM I-LF
+[ X O
+VCAM-1 PROPN B-AC
+] PUNCT O
+, PUNCT O
+Caveolin-3 NOUN B-LF
+[ X O
+Cav3 X B-AC
+] PUNCT O
+[ X O
+11–13 NUM O
+] PUNCT O
+) PUNCT O
+and CCONJ O
+their PRON O
+putative ADJ O
+adult NOUN O
+PRGs NOUN B-AC
+( PUNCT O
+stem NOUN B-LF
+cells NOUN I-LF
+antigen NOUN I-LF
+1 NUM I-LF
+[ X O
+Sca-1 NOUN B-AC
+] PUNCT O
+[ X O
+14,15 NUM O
+] PUNCT O
+, PUNCT O
+proto ADJ O
+- X O
+oncogene ADJ O
+receptor NOUN O
+tyrosine NOUN O
+kinase NOUN O
+[ X O
+c NOUN O
+- X O
+kit X O
+] PUNCT O
+[ X O
+16 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+FBs NOUN B-AC
+( PUNCT O
+discoidin NOUN B-LF
+domain NOUN I-LF
+receptor NOUN I-LF
+family NOUN I-LF
+member NOUN I-LF
+2 NUM I-LF
+[ X O
+Ddr2 PROPN B-AC
+] PUNCT O
+, PUNCT O
+thymus NOUN B-LF
+cell NOUN I-LF
+antigen NOUN I-LF
+1 NUM I-LF
+[ X O
+Thy1 PROPN B-AC
+] PUNCT O
+[ X O
+17,18 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+SMCs NOUN B-AC
+( PUNCT O
+platelet NOUN B-LF
+derived VERB I-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+beta NOUN I-LF
+[ X O
+PDGFrβ PROPN B-AC
+] PUNCT O
+[ X O
+19 NUM O
+] PUNCT O
+) PUNCT O
+and CCONJ O
+endothelial ADJ B-LF
+cells NOUN I-LF
+( PUNCT O
+ECs PROPN B-AC
+, PUNCT O
+platelet NOUN B-LF
+/ SYM I-LF
+endothelial ADJ I-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+1 NUM I-LF
+[ X O
+PECAM-1 PROPN B-AC
+] PUNCT O
+[ X O
+20 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+These DET O
+enzymes NOUN O
+catalyze VERB O
+the DET O
+hydroxylation NOUN O
+of ADP O
+proteins NOUN O
+, PUNCT O
+in ADP O
+a DET O
+manner NOUN O
+that PRON O
+is AUX O
+dependent ADJ O
+on ADP O
+the DET O
+availability NOUN O
+of ADP O
+molecular ADJ B-LF
+oxygen NOUN I-LF
+( PUNCT O
+O2 NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+One NUM O
+of ADP O
+the DET O
+most ADV O
+studied ADJ O
+mechanisms NOUN O
+of ADP O
+activation NOUN O
+of ADP O
+NRF2 PROPN B-AC
+are AUX O
+the DET O
+redox NOUN O
+stressors NOUN O
+, PUNCT O
+which PRON O
+put VERB O
+the DET O
+Kelch PROPN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+ECH NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+KEAP1 PROPN B-AC
+) PUNCT O
+out ADP O
+of ADP O
+play NOUN O
+. PUNCT O
+
+B NOUN O
+= PUNCT O
+Regression NOUN O
+coefficients NOUN O
+, PUNCT O
+OR NOUN B-AC
+= PUNCT O
+Odds NOUN B-LF
+ratio NOUN I-LF
+, PUNCT O
+BPMH NOUN B-AC
+= PUNCT O
+Best ADJ B-LF
+possible ADJ I-LF
+medication NOUN I-LF
+history NOUN I-LF
+
+A DET O
+health NOUN O
+facility NOUN O
+- ADJ O
+based VERB O
+cross ADJ O
+- ADJ O
+sectional ADJ O
+study NOUN O
+was AUX O
+conducted VERB O
+on ADP O
+403 NUM O
+neonates NOUN O
+admitted VERB O
+to ADP O
+the DET O
+neonatal ADJ B-LF
+intensive ADJ I-LF
+care NOUN I-LF
+units NOUN I-LF
+( PUNCT O
+NICUs PROPN B-AC
+) PUNCT O
+from ADP O
+January PROPN O
+2015 NUM O
+to ADP O
+December PROPN O
+2019 NUM O
+. PUNCT O
+
+Effective ADJ O
+treatment NOUN O
+is AUX O
+complicated VERB O
+by ADP O
+multidrug NOUN B-LF
+- PUNCT I-LF
+resistant ADJ I-LF
+TB PROPN B-AC
+( PUNCT O
+MDR PROPN B-AC
+TB PROPN B-AC
+) PUNCT O
+strains NOUN O
+that PRON O
+respond VERB O
+only ADV O
+to ADP O
+second ADJ O
+- PUNCT O
+line NOUN O
+drugs NOUN O
+. PUNCT O
+
+In ADP O
+concordance NOUN O
+, PUNCT O
+p38δFab PROPN O
+- PUNCT O
+KO PROPN O
+presented VERB O
+reduced VERB O
+energy NOUN O
+expenditure NOUN O
+, PUNCT O
+whole ADJ O
+- PUNCT O
+body NOUN O
+temperature NOUN O
+, PUNCT O
+and CCONJ O
+decreased VERB O
+BAT PROPN B-AC
+thermogenesis NOUN O
+( PUNCT O
+Fig PROPN O
+6E NUM O
+and CCONJ O
+6F NUM O
+) PUNCT O
+as ADP O
+well ADV O
+as ADP O
+lower ADJ O
+expression NOUN O
+levels NOUN O
+of ADP O
+Ucp1 PROPN O
+and CCONJ O
+Ppargc1β NOUN O
+in ADP O
+BAT PROPN B-AC
+( PUNCT O
+S10B NOUN O
+Fig PROPN O
+) PUNCT O
+with ADP O
+no DET O
+differences NOUN O
+in ADP O
+protein NOUN B-LF
+kinase NOUN I-LF
+A PROPN I-LF
+( PUNCT O
+PKA PROPN B-AC
+) PUNCT O
+phosphorylation NOUN O
+( PUNCT O
+S10C PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+IFN NOUN B-LF
+- NOUN I-LF
+α NOUN I-LF
+/ SYM I-LF
+β NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+IFNAR1 PROPN B-AC
+) PUNCT O
+signals NOUN O
+through ADP O
+the DET O
+JAK PROPN B-AC
+/ SYM O
+STAT PROPN B-AC
+pathway NOUN O
+by ADP O
+phosphorylation NOUN O
+of ADP O
+the DET O
+Janus PROPN B-LF
+kinase NOUN I-LF
+( PUNCT O
+JAK)1 PROPN B-AC
+, PUNCT O
+tyrosine NOUN O
+kinase NOUN O
+( PUNCT O
+Tyk)2 PROPN O
+, PUNCT O
+and CCONJ O
+signal NOUN B-LF
+transducer NOUN I-LF
+and CCONJ I-LF
+activator NOUN I-LF
+of ADP I-LF
+transcription NOUN I-LF
+( PUNCT O
+STAT)1 NOUN B-AC
+and CCONJ O
+STAT2 PROPN O
+, PUNCT O
+which PRON O
+subsequently ADV O
+modulates VERB O
+a DET O
+diverse ADJ O
+array NOUN O
+of ADP O
+genes NOUN O
+. PUNCT O
+
+The DET O
+disease NOUN O
+is AUX O
+characterised VERB O
+by ADP O
+the DET O
+deposition NOUN O
+in ADP O
+the DET O
+brain NOUN O
+of ADP O
+extracellular ADJ O
+plaques NOUN O
+of ADP O
+amyloid NOUN B-LF
+- PUNCT I-LF
+β NOUN I-LF
+( PUNCT O
+Aβ NOUN B-AC
+) PUNCT O
+which PRON O
+is AUX O
+derived VERB O
+from ADP O
+the DET O
+proteolytic ADJ O
+processing NOUN O
+of ADP O
+APP PROPN B-AC
+[ PUNCT O
+5 NUM O
+] PUNCT O
+, PUNCT O
+along ADP O
+with ADP O
+intracellular ADJ O
+neurofibrillary ADJ O
+tangles NOUN O
+of ADP O
+hyperphosphorylated VERB O
+tau NOUN O
+protein NOUN O
+[ PUNCT O
+6 NUM O
+] PUNCT O
+. PUNCT O
+
+KO PROPN B-AC
+, PUNCT O
+knock NOUN B-LF
+- PUNCT I-LF
+out NOUN I-LF
+; PUNCT O
+WT PROPN O
+, PUNCT O
+wild NOUN O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+We PRON O
+used VERB O
+Cox PROPN O
+- PUNCT O
+proportional ADJ O
+models NOUN O
+to PART O
+estimate VERB O
+minimally ADV O
+and CCONJ O
+fully ADV O
+adjusted VERB O
+hazard NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+HRs NOUN B-AC
+) PUNCT O
+with ADP O
+95 NUM O
+% NOUN O
+CIs NOUN O
+for ADP O
+mortality NOUN O
+following VERB O
+MAM PROPN B-AC
+and CCONJ O
+SAM PROPN B-AC
+by ADP O
+WLZ PROPN B-AC
+, PUNCT O
+MUAC PROPN B-AC
+, PUNCT O
+and CCONJ O
+oedema NOUN O
+( PUNCT O
+as ADP O
+relevant ADJ O
+) PUNCT O
+combined VERB O
+and CCONJ O
+then ADV O
+for ADP O
+individual ADJ O
+indicators NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+CrPAM PROPN O
+, PUNCT O
+C. NOUN O
+reinhardtii PROPN O
+peptidylglycine NOUN O
+α NOUN O
+- VERB O
+amidating VERB O
+monooxygenase NOUN O
+; PUNCT O
+FMG1 PROPN B-AC
+, PUNCT O
+flagellar ADJ B-LF
+membrane NOUN I-LF
+glycoprotein NOUN I-LF
+1 NUM I-LF
+. PUNCT O
+
+Type NOUN B-LF
+2 NUM I-LF
+diabetes NOUN I-LF
+mellitus NOUN I-LF
+( PUNCT O
+T2DM NOUN B-AC
+) PUNCT O
+disproportionately ADV O
+affects VERB O
+individuals NOUN O
+of ADP O
+nonwhite ADJ O
+ethnic ADJ O
+origin NOUN O
+. PUNCT O
+
+CFS PROPN B-AC
+, PUNCT O
+cross ADJ B-LF
+- ADJ I-LF
+frequency NOUN I-LF
+PS PROPN I-LF
+; PUNCT O
+HF PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+frequency NOUN I-LF
+; PUNCT O
+LF PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+frequency NOUN I-LF
+; PUNCT O
+MEG PROPN B-AC
+, PUNCT O
+magnetoencephalography NOUN B-LF
+; PUNCT O
+PAC PROPN B-AC
+, PUNCT O
+phase NOUN B-LF
+– PUNCT I-LF
+amplitude NOUN I-LF
+coupling NOUN I-LF
+; PUNCT O
+PS PROPN B-AC
+, PUNCT O
+phase NOUN B-LF
+synchrony NOUN I-LF
+; PUNCT O
+SEEG PROPN B-AC
+, PUNCT O
+stereoelectroencephalography NOUN B-LF
+. PUNCT O
+
+NSHD PROPN B-AC
+: PUNCT O
+Medical PROPN O
+Research PROPN O
+Council PROPN O
+National PROPN B-LF
+Survey PROPN I-LF
+of ADP I-LF
+Health PROPN I-LF
+and CCONJ I-LF
+Development PROPN I-LF
+, PUNCT O
+NCDS PROPN B-AC
+National PROPN B-LF
+Child PROPN I-LF
+Development PROPN I-LF
+Study PROPN I-LF
+, PUNCT O
+BCS PROPN B-AC
+: PUNCT O
+British PROPN B-LF
+Cohort PROPN I-LF
+Study PROPN I-LF
+, PUNCT O
+ALSPAC PROPN B-AC
+: PUNCT O
+Avon PROPN B-LF
+Longitudinal PROPN I-LF
+Study PROPN I-LF
+of ADP I-LF
+Parents PROPN I-LF
+and CCONJ I-LF
+Children PROPN I-LF
+, PUNCT O
+MCS PROPN B-AC
+: PUNCT O
+Millennium PROPN B-LF
+Cohort PROPN I-LF
+Study PROPN I-LF
+. PUNCT O
+
+Approaches NOUN O
+using VERB O
+HPV PROPN B-AC
+DNA NOUN O
+tests NOUN O
+can AUX O
+be AUX O
+easily ADV O
+adapted VERB O
+to ADP O
+resource NOUN O
+- PUNCT O
+limited VERB O
+settings NOUN O
+, PUNCT O
+allow VERB O
+for ADP O
+self NOUN O
+- PUNCT O
+collected VERB O
+samples NOUN O
+, PUNCT O
+and CCONJ O
+are AUX O
+less ADV O
+observer NOUN O
+dependent ADJ O
+than ADP O
+visual ADJ O
+inspection NOUN O
+methods NOUN O
+, PUNCT O
+which PRON O
+have VERB O
+variable ADJ O
+sensitivity NOUN O
+and CCONJ O
+specificity NOUN O
+among ADP O
+women NOUN B-LF
+living VERB I-LF
+with ADP I-LF
+HIV PROPN I-LF
+( PUNCT O
+WLHIV PROPN B-AC
+) PUNCT O
+[ PUNCT O
+4–6 NUM O
+] PUNCT O
+. PUNCT O
+
+Low ADJ O
+heart NOUN B-LF
+rate NOUN I-LF
+variability NOUN I-LF
+( PUNCT O
+HRV NOUN B-AC
+) PUNCT O
+has AUX O
+been AUX O
+linked VERB O
+to ADP O
+increased VERB O
+total ADJ O
+mortality NOUN O
+in ADP O
+the DET O
+general ADJ O
+population NOUN O
+; PUNCT O
+however ADV O
+, PUNCT O
+the DET O
+relationship NOUN O
+between ADP O
+low ADJ O
+HRV NOUN B-AC
+and CCONJ O
+sudden ADJ B-LF
+cardiac ADJ I-LF
+death NOUN I-LF
+( PUNCT O
+SCD NOUN B-AC
+) PUNCT O
+is AUX O
+less ADV O
+well ADV O
+- PUNCT O
+characterized VERB O
+. PUNCT O
+
+We PRON O
+aimed VERB O
+to PART O
+identify VERB O
+the DET O
+risk NOUN O
+factors NOUN O
+associated VERB O
+with ADP O
+colonic ADJ O
+cytomegalovirus NOUN B-LF
+( PUNCT O
+CMV NOUN B-AC
+) PUNCT O
+infection NOUN O
+in ADP O
+ulcerative ADJ B-LF
+colitis NOUN I-LF
+( PUNCT O
+UC PROPN B-AC
+) PUNCT O
+and CCONJ O
+to PART O
+compare VERB O
+the DET O
+clinical ADJ O
+course NOUN O
+between ADP O
+antiviral ADJ O
+therapy NOUN O
+- NOUN O
+treated VERB O
+and CCONJ O
+-untreated ADJ O
+groups NOUN O
+in ADP O
+mucosal ADJ O
+CMV NOUN B-AC
+- NOUN O
+polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+PCR PROPN B-AC
+) PUNCT O
+-positive ADJ O
+cases NOUN O
+. PUNCT O
+
+The DET O
+Model PROPN B-LF
+for ADP I-LF
+End PROPN I-LF
+Stage PROPN I-LF
+Liver PROPN I-LF
+Disease PROPN I-LF
+( PUNCT O
+MELD PROPN B-AC
+) PUNCT O
+has AUX O
+been AUX O
+used VERB O
+as ADP O
+the DET O
+method NOUN O
+of ADP O
+liver NOUN O
+graft NOUN O
+allocation NOUN O
+since SCONJ O
+2002 NUM O
+. PUNCT O
+
+Crohn PROPN B-LF
+’s PART I-LF
+disease NOUN I-LF
+[ X O
+CD NOUN B-AC
+] PUNCT O
+and CCONJ O
+ulcerative ADJ B-LF
+colitis NOUN I-LF
+[ X O
+UC])[1 X B-AC
+] PUNCT O
+. PUNCT O
+
+All DET O
+biological ADJ O
+processes NOUN O
+in ADP O
+apicomplexan ADJ O
+parasites NOUN O
+known VERB O
+to PART O
+require VERB O
+PKG PROPN B-AC
+are AUX O
+also ADV O
+thought VERB O
+to PART O
+rely VERB O
+on ADP O
+the DET O
+release NOUN O
+of ADP O
+Ca2 NOUN O
++ NOUN O
+from ADP O
+intracellular ADJ O
+stores NOUN O
+[ PUNCT O
+11],[31],[32],[35],[36 NUM O
+] PUNCT O
+, PUNCT O
+which PRON O
+in ADP O
+turn NOUN O
+activates VERB O
+distinct ADJ O
+stage NOUN O
+- PUNCT O
+specific ADJ O
+effector NOUN O
+pathways NOUN O
+including VERB O
+members NOUN O
+of ADP O
+a DET O
+family NOUN O
+of ADP O
+plant NOUN O
+- PUNCT O
+like ADJ O
+Ca2 NOUN B-LF
++ NOUN I-LF
+-dependent ADJ I-LF
+protein NOUN I-LF
+kinases NOUN I-LF
+( PUNCT O
+CDPKs PROPN B-AC
+) PUNCT O
+[ PUNCT O
+37 NUM O
+] PUNCT O
+. PUNCT O
+
+To PART O
+first ADV O
+assay VERB O
+this PRON O
+, PUNCT O
+TrkC PROPN B-AC
+- PUNCT B-AC
+KF PROPN B-AC
+was AUX O
+fused VERB O
+to PART O
+a DET O
+Gal4 PROPN O
+DNA NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+domain NOUN I-LF
+( PUNCT O
+DBD PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+SHEP PROPN O
+cells NOUN O
+were AUX O
+forced VERB O
+to PART O
+express VERB O
+TrkC PROPN B-AC
+- PUNCT B-AC
+KF PROPN B-AC
+- PUNCT O
+Gal4DBD PROPN O
+together ADV O
+with ADP O
+a DET O
+construct NOUN O
+encoding VERB O
+a DET O
+luciferase NOUN O
+reporter NOUN O
+gene NOUN O
+under ADP O
+the DET O
+control NOUN O
+of ADP O
+the DET O
+upstream ADJ B-LF
+activating VERB I-LF
+sequence NOUN I-LF
+( PUNCT O
+UAS)-GAL4 PROPN B-AC
+promoter NOUN O
+. PUNCT O
+
+We PRON O
+conducted VERB O
+a DET O
+retrospective ADJ O
+chart NOUN O
+review NOUN O
+of ADP O
+all DET O
+male ADJ O
+patients NOUN O
+seen VERB O
+in ADP O
+the DET O
+Pediatric PROPN O
+Endocrinology PROPN O
+Division PROPN O
+at ADP O
+Boston PROPN B-LF
+Children PROPN I-LF
+’s PART I-LF
+Hospital PROPN I-LF
+( PUNCT O
+BCH PROPN B-AC
+) PUNCT O
+between ADP O
+2001–2010 NUM O
+with ADP O
+an DET O
+International PROPN B-LF
+Statistical PROPN I-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+9th ADJ I-LF
+edition NOUN I-LF
+( PUNCT O
+ICD-9 NOUN B-AC
+) PUNCT O
+code NOUN O
+for ADP O
+PP PROPN B-AC
+( PUNCT O
+ICD-9 NOUN B-AC
+259.1 NUM O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+2013 NUM O
+, PUNCT O
+the DET O
+benchmark NOUN O
+CANONIC PROPN B-AC
+Study PROPN O
+by ADP O
+the DET B-LF
+European PROPN I-LF
+Association PROPN I-LF
+for ADP I-LF
+the DET I-LF
+Study PROPN I-LF
+of ADP I-LF
+the DET I-LF
+Liver PROPN I-LF
+- PUNCT O
+Chronic PROPN B-LF
+Liver PROPN I-LF
+Failure PROPN I-LF
+Consortium PROPN I-LF
+( PUNCT O
+EASL PROPN B-AC
+CLIF PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+) PUNCT O
+introduced VERB O
+the DET O
+concept NOUN O
+of ADP O
+analyzing VERB O
+each DET O
+“ PUNCT O
+acute ADJ B-LF
+decompensation NOUN I-LF
+( PUNCT O
+AD NOUN B-AC
+) PUNCT O
+” PUNCT O
+of ADP O
+cirrhosis NOUN O
+, PUNCT O
+characterized VERB O
+end NOUN O
+- PUNCT O
+organ NOUN O
+insufficiency NOUN O
+in ADP O
+six NUM O
+organ NOUN O
+systems NOUN O
+, PUNCT O
+and CCONJ O
+practically ADV O
+and CCONJ O
+clearly ADV O
+defined VERB O
+the DET O
+clinical ADJ O
+state NOUN O
+of ADP O
+“ PUNCT O
+acute ADJ B-LF
+- PUNCT I-LF
+on ADP I-LF
+- PUNCT I-LF
+chronic ADJ I-LF
+liver NOUN I-LF
+failure NOUN I-LF
+( PUNCT O
+ACLF PROPN B-AC
+) PUNCT O
+” PUNCT O
+[ PUNCT O
+3 NUM O
+] PUNCT O
+. PUNCT O
+
+AA PROPN O
+, PUNCT O
+CRY171A/280A PROPN O
+; PUNCT O
+CRY1 PROPN O
+, PUNCT O
+CRYPTOCHROME PROPN O
+1 NUM O
+; PUNCT O
+JMJD5 PROPN B-AC
+, PUNCT O
+JmjC PROPN B-LF
+domain NOUN I-LF
+– PUNCT I-LF
+containing VERB I-LF
+protein NOUN I-LF
+5 NUM I-LF
+. PUNCT O
+
+In ADP O
+order NOUN O
+to ADP O
+confirm VERB O
+that SCONJ O
+MITF PROPN O
+binds VERB O
+to ADP O
+these DET O
+loci NOUN O
+in ADP O
+mouse NOUN O
+melanocytes NOUN O
+, PUNCT O
+we PRON O
+assessed VERB O
+MITF PROPN O
+occupancy NOUN O
+using VERB O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+quantitative ADJ I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+ChIP PROPN B-AC
+- PUNCT B-AC
+qPCR PROPN B-AC
+) PUNCT O
+for ADP O
+three NUM O
+of ADP O
+the DET O
+seven NUM O
+ISGs NOUN B-AC
+in ADP O
+melan NOUN O
+- PUNCT O
+a NOUN O
+cells NOUN O
+. PUNCT O
+
+FDR PROPN O
+, PUNCT O
+false ADJ O
+discovery NOUN O
+rate NOUN O
+; PUNCT O
+iEEG PROPN B-AC
+, PUNCT O
+intracranial ADJ O
+electroencephalography NOUN O
+; PUNCT O
+ROI NOUN B-AC
+, PUNCT O
+region NOUN B-LF
+of ADP I-LF
+interest NOUN I-LF
+; PUNCT O
+SME NOUN B-AC
+, PUNCT O
+subsequent ADJ B-LF
+memory NOUN I-LF
+effect NOUN I-LF
+. PUNCT O
+
+Hormone NOUN O
+biosynthetic ADJ O
+mutants NOUN O
+that PRON O
+reduce VERB O
+production NOUN O
+of ADP O
+the DET O
+dafachronic ADJ B-LF
+acids NOUN I-LF
+( PUNCT O
+DAs PROPN B-AC
+) PUNCT O
+have VERB O
+a DET O
+characteristic ADJ O
+phenotypic ADJ O
+profile NOUN O
+. PUNCT O
+
+LV NOUN O
+/ SYM O
+RVES NOUN O
+/ SYM O
+DVI- NOUN O
+left ADJ O
+/ SYM O
+right ADJ O
+ventricular ADJ O
+end NOUN O
+- PUNCT O
+systolic ADJ O
+/ SYM O
+diastolic ADJ O
+volume NOUN O
+indexed VERB O
+, PUNCT O
+LV NOUN O
+/ SYM O
+RVEF- NOUN B-AC
+left ADJ O
+/ SYM O
+right ADJ B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+, PUNCT O
+RVOTD NOUN O
+/ SYM O
+VI- NOUN O
+right ADJ O
+ventricular ADJ O
+outflow NOUN O
+tract NOUN O
+diameter NOUN O
+/ SYM O
+volume NOUN O
+indexed VERB O
+. PUNCT O
+
+The DET O
+4 NUM O
+blue ADJ O
+arrows NOUN O
+indicate VERB O
+4 NUM O
+of ADP O
+the DET O
+above ADJ O
+8 NUM O
+patients NOUN O
+who PRON O
+were AUX O
+ctDNA PROPN B-AC
+non NOUN O
+- ADJ O
+clearance NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+4 NUM O
+yellow ADJ O
+arrows NOUN O
+indicate VERB O
+the DET O
+other ADJ O
+4 NUM O
+patients NOUN O
+who PRON O
+were AUX O
+ctDNA PROPN B-AC
+clearance NOUN O
+. PUNCT O
+( PUNCT O
+B X O
+) PUNCT O
+The DET O
+distribution NOUN O
+of ADP O
+patients NOUN O
+with ADP O
+acquired VERB O
+mutations NOUN O
+in ADP O
+different ADJ O
+clinicopathological ADJ O
+groups NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+103 NUM O
+) PUNCT O
+. PUNCT O
+cCR PROPN B-AC
+, PUNCT O
+clinical ADJ B-LF
+complete ADJ I-LF
+response NOUN I-LF
+; PUNCT O
+ctDNA PROPN B-AC
+, PUNCT O
+circulating VERB B-LF
+tumor NOUN I-LF
+DNA NOUN I-LF
+; PUNCT O
+MRI PROPN B-AC
+, PUNCT O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+; PUNCT O
+mrTRG PROPN B-AC
+, PUNCT O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+tumor NOUN I-LF
+regression NOUN I-LF
+grade NOUN I-LF
+; PUNCT O
+nCRT PROPN B-AC
+, PUNCT O
+neoadjuvant ADJ B-LF
+chemoradiotherapy NOUN I-LF
+; PUNCT O
+pCR NOUN B-AC
+, PUNCT O
+pathological ADJ B-LF
+complete ADJ I-LF
+response NOUN I-LF
+; PUNCT O
+pTRG PROPN B-AC
+, PUNCT O
+pathological ADJ B-LF
+tumor NOUN I-LF
+regression NOUN I-LF
+grade NOUN I-LF
+; PUNCT O
+VAF PROPN B-AC
+, PUNCT O
+variant NOUN B-LF
+allele NOUN I-LF
+frequency NOUN I-LF
+. PUNCT O
+
+No DET O
+volunteer NOUN O
+had VERB O
+a DET O
+positive ADJ O
+HIV PROPN O
+enzyme NOUN B-LF
+immunoassay NOUN I-LF
+( PUNCT O
+EIA PROPN B-AC
+) PUNCT O
+response NOUN O
+during ADP O
+the DET O
+study NOUN O
+. PUNCT O
+
+MCI PROPN B-AC
+, PUNCT O
+mild ADJ B-LF
+cognitive ADJ I-LF
+impairment NOUN I-LF
+
+We PRON O
+stimulated VERB O
+freshly ADV O
+isolated VERB O
+fetal ADJ O
+liver NOUN O
+cells NOUN O
+with ADP O
+Epo PROPN B-AC
+and CCONJ O
+examined VERB O
+the DET O
+resulting VERB O
+p NOUN B-AC
+- PUNCT B-AC
+Stat5 NOUN B-AC
+response NOUN O
+in ADP O
+each PRON O
+of ADP O
+the DET O
+fetal ADJ O
+liver NOUN O
+subsets NOUN O
+( PUNCT O
+Figure NOUN O
+S1A NOUN O
+; PUNCT O
+Figure NOUN O
+1C NUM O
+– SYM O
+E NOUN O
+) PUNCT O
+. PUNCT O
+We PRON O
+measured VERB O
+three NUM O
+aspects NOUN O
+of ADP O
+the DET O
+p NOUN B-AC
+- PUNCT B-AC
+Stat5 NOUN B-AC
+fluorescence NOUN O
+signal NOUN O
+( PUNCT O
+Figure NOUN O
+1C NUM O
+) PUNCT O
+. PUNCT O
+First ADV O
+, PUNCT O
+“ PUNCT O
+total ADJ O
+p NOUN B-AC
+- PUNCT B-AC
+Stat5 NOUN B-AC
+” PUNCT O
+corresponds VERB O
+to ADP O
+the DET O
+p NOUN B-AC
+- PUNCT B-AC
+Stat5 NOUN B-AC
+median ADJ B-LF
+fluorescence NOUN I-LF
+intensity NOUN I-LF
+( PUNCT O
+MFI PROPN B-AC
+) PUNCT O
+of ADP O
+the DET O
+entire ADJ O
+subset NOUN O
+population NOUN O
+; PUNCT O
+the DET O
+total ADJ O
+p NOUN B-AC
+- PUNCT B-AC
+Stat5 NOUN B-AC
+MFI PROPN B-AC
+of ADP O
+all DET O
+S3 PROPN O
+subset NOUN O
+cells NOUN O
+in ADP O
+the DET O
+red ADJ O
+histogram NOUN O
+, PUNCT O
+upper ADJ O
+panel NOUN O
+of ADP O
+Figure NOUN O
+1C NUM O
+, PUNCT O
+is AUX O
+1,200 NUM O
+fluorescence NOUN O
+units NOUN O
+. PUNCT O
+
+BMDC PROPN B-AC
+( PUNCT O
+Kb PROPN O
+haplotype NOUN O
+) PUNCT O
+were AUX O
+cultured VERB O
+from ADP O
+WT PROPN O
+and CCONJ O
+TLR2−/− NOUN O
+bone NOUN O
+marrow NOUN O
+for ADP O
+7 NUM O
+d NOUN O
+as SCONJ O
+described VERB O
+previously ADV O
+, PUNCT O
+then ADV O
+activated VERB O
+by ADP O
+incubating VERB O
+with ADP O
+100 NUM O
+μg NOUN O
+/ ADP O
+ml NOUN O
+GL26 NOUN O
+cell NOUN O
+extract NOUN O
+for ADP O
+24 NUM O
+h NOUN O
+( PUNCT O
+at ADP O
+37 NUM O
+° NOUN O
+C NOUN O
+) PUNCT O
+. PUNCT O
+CD4 PROPN O
+and CCONJ O
+CD8 PROPN O
+T NOUN O
+cells NOUN O
+were AUX O
+isolated VERB O
+using VERB O
+a DET O
+magnetic ADJ B-LF
+activated VERB I-LF
+cell NOUN I-LF
+sorter NOUN I-LF
+( PUNCT O
+MACS PROPN B-AC
+) PUNCT O
+from ADP O
+total ADJ O
+splenocytes NOUN O
+of ADP O
+Balb(c NOUN O
+) PUNCT O
+mice NOUN O
+( PUNCT O
+Kd PROPN O
+haplotype NOUN O
+) PUNCT O
+using VERB O
+mouse NOUN O
+CD4 PROPN O
+( PUNCT O
+L3T4 PROPN O
+) PUNCT O
+and CCONJ O
+CD8a NOUN O
+( PUNCT O
+Ly-2 PROPN O
+) PUNCT O
+magnetic ADJ O
+beads NOUN O
+( PUNCT O
+Miltenyi PROPN O
+Biotec PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+current ADJ O
+biomarkers NOUN O
+for ADP O
+diagnosis NOUN O
+of ADP O
+sepsis NOUN O
+or CCONJ O
+infections NOUN O
+include VERB O
+white ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+( PUNCT O
+WBC PROPN B-AC
+) PUNCT O
+count NOUN O
+, PUNCT O
+lactic ADJ O
+acid NOUN O
+, PUNCT O
+procalcitonin NOUN O
+, PUNCT O
+and CCONJ O
+C NOUN B-LF
+- NOUN I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+CRP PROPN B-AC
+) PUNCT O
+[ PUNCT O
+1–3 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET B-AC
+majority NOUN O
+of ADP O
+known VERB O
+virulence NOUN O
+factors NOUN O
+, PUNCT O
+including VERB O
+adhesins NOUN O
+( PUNCT O
+filamentous ADJ B-LF
+hemagglutinin NOUN I-LF
+[ PUNCT O
+FHA PROPN B-AC
+] PUNCT O
+, PUNCT O
+pertactin NOUN O
+, PUNCT O
+and CCONJ O
+fimbriae NOUN O
+) PUNCT O
+and CCONJ O
+toxins NOUN O
+( PUNCT O
+adenylate NOUN B-LF
+cyclase NOUN I-LF
+toxin NOUN I-LF
+[ PUNCT O
+ACT PROPN B-AC
+] PUNCT O
+and CCONJ O
+dermonecrotic ADJ O
+toxin NOUN O
+) PUNCT O
+are AUX O
+expressed VERB O
+by ADP O
+both DET O
+B. PROPN O
+bronchiseptica NOUN O
+and CCONJ O
+B. PROPN O
+pertussis NOUN O
+. PUNCT O
+
+Hazard NOUN B-LF
+quotient NOUN I-LF
+( PUNCT O
+HQ NOUN B-AC
+) PUNCT O
+was AUX O
+used VERB O
+for ADP O
+long ADJ O
+- PUNCT O
+term NOUN O
+risk NOUN O
+assessment NOUN O
+. PUNCT O
+HQ NOUN B-AC
+( PUNCT O
+% NOUN O
+) PUNCT O
+= SYM O
+EDI NOUN B-AC
+/ SYM O
+ADI PROPN B-AC
+× SYM O
+100(7 NUM O
+) PUNCT O
+where SCONJ O
+ADI PROPN B-AC
+was AUX O
+the DET O
+acceptable ADJ B-LF
+daily ADJ I-LF
+intake NOUN I-LF
+of ADP O
+a DET O
+pesticide NOUN O
+. PUNCT O
+
+This DET O
+study NOUN O
+was AUX O
+prospectively ADV O
+registered VERB O
+in ADP O
+International PROPN B-LF
+Prospective PROPN I-LF
+Register PROPN I-LF
+of ADP I-LF
+Systematic PROPN I-LF
+Reviews PROPN I-LF
+( PUNCT O
+PROSPERO PROPN B-AC
+; PUNCT O
+CRD42017069087 NUM O
+) PUNCT O
+. PUNCT O
+
+Patient PROPN B-LF
+Reported PROPN I-LF
+Outcomes NOUN I-LF
+( PUNCT O
+PRO PROPN B-AC
+) PUNCT O
+are AUX O
+established VERB O
+outcome NOUN O
+parameters NOUN O
+[ X O
+54 NUM O
+] PUNCT O
+. PUNCT O
+
+However ADV O
+, PUNCT O
+majority NOUN O
+( PUNCT O
+88 NUM O
+% NOUN O
+) PUNCT O
+of ADP O
+the DET O
+HCC PROPN B-AC
+samples NOUN O
+used VERB O
+in ADP O
+their PRON O
+study NOUN O
+have VERB O
+hepatitis NOUN B-LF
+B NOUN I-LF
+virus NOUN I-LF
+( PUNCT O
+HBV PROPN B-AC
+) PUNCT O
+infection NOUN O
+and CCONJ O
+the DET O
+association NOUN O
+between ADP O
+Cu PROPN B-AC
+/ SYM O
+Zn PROPN B-AC
+and CCONJ O
+survival NOUN O
+was AUX O
+prominent ADJ O
+only ADV O
+among ADP O
+hepatitis NOUN O
+B NOUN O
+negative ADJ O
+patients NOUN O
+. PUNCT O
+
+Both DET O
+studies NOUN O
+were AUX O
+approved VERB O
+by ADP O
+the DET O
+Institutional PROPN O
+Review PROPN O
+Board PROPN O
+Committee PROPN O
+of ADP O
+the DET O
+Taiwan PROPN B-LF
+Centers PROPN I-LF
+for ADP I-LF
+Disease PROPN I-LF
+Control PROPN I-LF
+( PUNCT O
+CDC PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Failure NOUN O
+is AUX O
+given VERB O
+after ADP O
+1 NUM O
+and CCONJ O
+2 NUM O
+years NOUN O
+of ADP O
+ART PROPN B-AC
+. PUNCT O
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+DTG PROPN B-AC
+, PUNCT O
+dolutegravir NOUN B-LF
+; PUNCT O
+NNRTI PROPN B-AC
+, PUNCT O
+non ADJ B-LF
+- ADJ I-LF
+nucleoside ADJ I-LF
+reverse ADJ I-LF
+transcriptase NOUN I-LF
+inhibitor NOUN I-LF
+. PUNCT O
+
+ASC PROPN B-AC
+, PUNCT O
+apoptosis NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+speck NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+BMDM PROPN B-AC
+, PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+– PUNCT I-LF
+derived VERB I-LF
+macrophage NOUN I-LF
+; PUNCT O
+CRISPR NOUN B-AC
+- PUNCT B-AC
+Cas9 PROPN B-AC
+, PUNCT O
+clustered VERB B-LF
+regularly ADV I-LF
+interspersed VERB I-LF
+short ADJ I-LF
+palindromic ADJ I-LF
+repeats NOUN I-LF
+– PUNCT I-LF
+CRISPR NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+9 NUM I-LF
+; PUNCT O
+gRNA NOUN O
+, PUNCT O
+guide NOUN O
+RNA NOUN O
+; PUNCT O
+PAM PROPN O
+, PUNCT O
+protospacer NOUN O
+adjacent ADJ O
+motif NOUN O
+; PUNCT O
+PCR PROPN O
+, PUNCT O
+polymerase NOUN O
+chain NOUN O
+reaction NOUN O
+. PUNCT O
+
+As SCONJ O
+reported VERB O
+by ADP O
+Mendelian ADJ O
+randomization NOUN O
+studies NOUN O
+, PUNCT O
+a DET O
+lifetime NOUN O
+reduction NOUN O
+of ADP O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+cholesterol NOUN I-LF
+( PUNCT O
+LDL NOUN B-AC
+- PUNCT B-AC
+C NOUN B-AC
+) PUNCT O
+of ADP O
+1 NUM O
+mmol NOUN O
+/ SYM O
+l NOUN O
+might AUX O
+reduce VERB O
+the DET O
+potential ADJ O
+risk NOUN O
+of ADP O
+atherosclerotic ADJ O
+CVDs NOUN B-AC
+by ADP O
+over ADP O
+50 NUM O
+% NOUN O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+used VERB O
+the DET O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+( PUNCT O
+AUC PROPN B-AC
+) PUNCT O
+of ADP O
+a DET O
+receiver NOUN B-LF
+operator NOUN I-LF
+characteristics NOUN I-LF
+( PUNCT O
+ROC PROPN B-AC
+) PUNCT O
+graph NOUN O
+to PART O
+assess VERB O
+the DET O
+accuracy NOUN O
+of ADP O
+the DET O
+PwD PROPN B-AC
+, PUNCT O
+BED PROPN B-AC
+and CCONJ O
+Lag PROPN O
+assays NOUN O
+to PART O
+identify VERB O
+HIV PROPN O
+infection NOUN O
+recency NOUN O
+. PUNCT O
+
+This DET O
+study NOUN O
+used VERB O
+the DET O
+Life PROPN B-LF
+Support PROPN I-LF
+Preferences PROPN I-LF
+Questionnaire PROPN I-LF
+( PUNCT O
+LSPQ PROPN B-AC
+) PUNCT O
+to PART O
+explore VERB O
+whether SCONJ O
+family NOUN O
+carers NOUN O
+’ PART O
+choices NOUN O
+show VERB O
+agreement NOUN O
+with ADP O
+the DET O
+end NOUN O
+of ADP O
+life NOUN O
+care VERB O
+preferences NOUN O
+of ADP O
+the DET O
+person NOUN O
+with ADP O
+dementia NOUN O
+for ADP O
+whom PRON O
+they PRON O
+care VERB O
+and CCONJ O
+what DET O
+factors NOUN O
+influence VERB O
+this PRON O
+. PUNCT O
+
+Up ADP O
+to ADP O
+5 NUM O
+% NOUN O
+Gross PROPN B-LF
+Domestic PROPN I-LF
+Product PROPN I-LF
+( PUNCT O
+GDP PROPN B-AC
+) PUNCT O
+economic ADJ O
+loss NOUN O
+is AUX O
+attributed VERB O
+to ADP O
+Road NOUN O
+traffic NOUN O
+deaths NOUN O
+and CCONJ O
+injuries NOUN O
+in ADP O
+low ADJ O
+and CCONJ O
+middle NOUN O
+- PUNCT O
+income NOUN O
+countries NOUN O
+[ PUNCT O
+9 NUM O
+, PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+Arp2/3 NOUN B-AC
+, PUNCT O
+actin NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+protein NOUN I-LF
+2/3 NUM I-LF
+; PUNCT O
+WASp PROPN B-AC
+, PUNCT O
+Wiskott PROPN B-LF
+– PUNCT I-LF
+Aldrich PROPN I-LF
+syndrome PROPN I-LF
+protein NOUN I-LF
+. PUNCT O
+
+To PART O
+examine VERB O
+this PRON O
+, PUNCT O
+we PRON O
+performed VERB O
+glutathione NOUN B-LF
+s NOUN I-LF
+- NOUN I-LF
+transferase NOUN I-LF
+( PUNCT O
+GST PROPN B-AC
+) PUNCT O
+pull VERB O
+- NOUN O
+down ADP O
+experiments NOUN O
+followed VERB O
+by ADP O
+western ADJ O
+blot NOUN O
+confirmation NOUN O
+using VERB O
+recombinant ADJ O
+CsgF PROPN O
+variant NOUN O
+proteins NOUN O
+that PRON O
+are AUX O
+fused VERB O
+to ADP O
+GST PROPN B-AC
+C PROPN O
+- NOUN O
+terminally ADV O
+. PUNCT O
+
+While SCONJ O
+analysing VERB O
+the DET O
+proportion NOUN O
+of ADP O
+axons NOUN O
+that SCONJ O
+are AUX O
+myelinated VERB O
+at ADP O
+P40 NUM O
+, PUNCT O
+we PRON O
+observed VERB O
+, PUNCT O
+paradoxically ADV O
+, PUNCT O
+that SCONJ O
+despite SCONJ O
+the DET O
+reduced VERB O
+initiation NOUN O
+in ADP O
+smaller ADJ O
+diameter NOUN O
+axons NOUN O
+, PUNCT O
+fully ADV O
+compacted VERB O
+myelin NOUN O
+sheaths NOUN O
+that SCONJ O
+were AUX O
+formed VERB O
+in ADP O
+Scribble PROPN O
+cKO PROPN B-AC
+optic ADJ O
+nerve NOUN O
+and CCONJ O
+spinal ADJ O
+cord NOUN O
+( PUNCT O
+Fig PROPN O
+. PUNCT O
+7B NUM O
+, PUNCT O
+E NOUN O
+) PUNCT O
+appeared VERB O
+thicker ADJ O
+than ADP O
+those PRON O
+in ADP O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+animals NOUN O
+( PUNCT O
+Fig PROPN O
+. PUNCT O
+7A NUM O
+, PUNCT O
+D NOUN O
+) PUNCT O
+. PUNCT O
+Quantification NOUN O
+of ADP O
+the DET O
+g NOUN O
+- PUNCT O
+ratio NOUN O
+( PUNCT O
+the DET O
+ratio NOUN O
+of ADP O
+axon NOUN O
+circumference NOUN O
+to ADP O
+myelin NOUN O
+circumference NOUN O
+) PUNCT O
+confirmed VERB O
+this DET O
+, PUNCT O
+being AUX O
+decreased VERB O
+in ADP O
+Scribble PROPN O
+cKO PROPN B-AC
+optic ADJ O
+nerve NOUN O
+and CCONJ O
+spinal ADJ O
+cord NOUN O
+relative ADJ O
+to ADP O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+fibres NOUN O
+( PUNCT O
+Fig PROPN O
+. PUNCT O
+7 NUM O
+G NOUN O
+) PUNCT O
+. PUNCT O
+When SCONJ O
+this DET O
+ratio NOUN O
+was AUX O
+plotted VERB O
+against ADP O
+axon NOUN O
+diameter NOUN O
+, PUNCT O
+lower ADJ O
+values NOUN O
+were AUX O
+seen VERB O
+for ADP O
+all DET O
+axon NOUN O
+diameters NOUN O
+and CCONJ O
+the DET O
+equations NOUN O
+for ADP O
+the DET O
+best ADJ O
+- PUNCT O
+fit NOUN O
+lines NOUN O
+for ADP O
+WT PROPN B-AC
+and CCONJ O
+cKO PROPN B-AC
+datasets NOUN O
+obtained VERB O
+by ADP O
+linear ADJ O
+regression NOUN O
+differed VERB O
+significantly ADV O
+in ADP O
+both CCONJ O
+optic ADJ O
+nerve NOUN O
+( PUNCT O
+Fig PROPN O
+. PUNCT O
+7H NUM O
+) PUNCT O
+and CCONJ O
+spinal ADJ O
+cord NOUN O
+( PUNCT O
+Fig PROPN O
+. PUNCT O
+7I NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+periodicity NOUN O
+of ADP O
+myelin NOUN O
+lamellae NOUN O
+was AUX O
+unchanged ADJ O
+in ADP O
+both CCONJ O
+optic ADJ O
+nerve NOUN O
+and CCONJ O
+spinal ADJ O
+cord NOUN O
+( PUNCT O
+S2 PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+indicating VERB O
+that SCONJ O
+the DET O
+decreased VERB O
+g NOUN O
+- PUNCT O
+ratios NOUN O
+were AUX O
+due ADJ O
+to ADP O
+the DET O
+presence NOUN O
+of ADP O
+more ADJ O
+myelin NOUN O
+wraps NOUN O
+, PUNCT O
+not PART O
+increased VERB O
+spacing NOUN O
+between ADP O
+them PRON O
+. PUNCT O
+
+Mechanistically ADV O
+, PUNCT O
+the DET O
+N NOUN O
+- NOUN O
+terminus NOUN O
+of ADP O
+CEP290 PROPN B-AC
+directly ADV O
+recruits VERB O
+DAZ NOUN B-LF
+interacting VERB I-LF
+zinc NOUN I-LF
+finger NOUN I-LF
+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+DZIP1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+then ADV O
+recruits VERB O
+Chibby PROPN B-LF
+( PUNCT O
+CBY PROPN B-AC
+) PUNCT O
+and CCONJ O
+Rab8 PROPN O
+to PART O
+promote VERB O
+early ADJ O
+ciliary ADJ O
+membrane NOUN O
+formation NOUN O
+. PUNCT O
+
+This PRON O
+is AUX O
+consistent ADJ O
+with ADP O
+MHC PROPN B-AC
+class NOUN O
+I NUM O
+evolving VERB O
+faster ADV O
+than ADP O
+class NOUN O
+II NUM O
+because SCONJ O
+of ADP O
+pressure NOUN O
+from ADP O
+rapidly ADV O
+evolving VERB O
+intracellular ADJ O
+pathogens NOUN O
+such ADJ O
+as ADP O
+RNA NOUN O
+viruses NOUN O
+, PUNCT O
+like ADP O
+the DET O
+human ADJ B-LF
+immunodeficiency NOUN I-LF
+viruses NOUN I-LF
+( PUNCT O
+HIV PROPN B-AC
+) PUNCT O
+. PUNCT O
+In ADP O
+fact NOUN O
+, PUNCT O
+the DET O
+great ADJ O
+apes NOUN O
+( PUNCT O
+chimpanzee NOUN O
+, PUNCT O
+bonobo NOUN O
+, PUNCT O
+gorilla NOUN O
+, PUNCT O
+and CCONJ O
+orangutan NOUN O
+) PUNCT O
+are AUX O
+the DET O
+only ADJ O
+living VERB O
+species NOUN O
+that PRON O
+have VERB O
+orthologs NOUN O
+of ADP O
+all DET O
+three NUM O
+polymorphic ADJ O
+human ADJ O
+MHC PROPN B-AC
+class NOUN O
+I NUM O
+molecules NOUN O
+, PUNCT O
+HLA PROPN O
+- PUNCT O
+A PROPN O
+, PUNCT O
+-B PROPN O
+, PUNCT O
+and CCONJ O
+-C PROPN O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+Furthermore ADV O
+, PUNCT O
+Dermitzakis PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+showed VERB O
+that PRON O
+conserved ADJ B-LF
+nongenic ADJ I-LF
+sequences NOUN I-LF
+( PUNCT O
+CNGs PROPN B-AC
+) PUNCT O
+, PUNCT O
+ungapped ADJ O
+100 NUM O
+- PUNCT O
+bp NOUN O
+fragments NOUN O
+with ADP O
+at ADV O
+least ADV O
+70 NUM O
+% NOUN O
+identity NOUN O
+between ADP O
+human NOUN O
+and CCONJ O
+mouse NOUN O
+that PRON O
+are AUX O
+presumed VERB O
+factor NOUN O
+- PUNCT O
+binding VERB O
+regions NOUN O
+, PUNCT O
+have VERB O
+no DET O
+significant ADJ O
+preference NOUN O
+for ADP O
+promoter NOUN O
+proximal ADJ O
+regions NOUN O
+[ X O
+27,28 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET B-LF
+ratio NOUN I-LF
+of ADP I-LF
+residual ADJ I-LF
+volume NOUN I-LF
+to ADP I-LF
+total ADJ I-LF
+lung NOUN I-LF
+capacity NOUN I-LF
+( PUNCT O
+RV NOUN B-AC
+/ SYM B-AC
+TLC NOUN B-AC
+) PUNCT O
+is AUX O
+a DET O
+more ADV O
+comprehensive ADJ O
+parameter NOUN O
+that PRON O
+could AUX O
+be AUX O
+readily ADV O
+calculated VERB O
+based VERB O
+on ADP O
+the DET O
+functional ADJ O
+residual ADJ O
+capacity NOUN O
+. PUNCT O
+
+We PRON O
+estimated VERB O
+the DET O
+association NOUN O
+of ADP O
+AO PROPN B-AC
+and CCONJ O
+cardiovascular ADJ B-LF
+risk NOUN I-LF
+factors NOUN I-LF
+( PUNCT O
+CVRF PROPN B-AC
+) PUNCT O
+and CCONJ O
+disease NOUN O
+in ADP O
+non ADJ O
+- ADJ O
+obese ADJ O
+adult ADJ O
+individuals NOUN O
+from ADP O
+Chile PROPN O
+. PUNCT O
+
+PSD PROPN B-AC
+, PUNCT O
+power NOUN B-LF
+spectrum NOUN I-LF
+density NOUN I-LF
+; PUNCT O
+ANOVA NOUN B-AC
+, PUNCT O
+analysis NOUN B-LF
+of ADP I-LF
+variance NOUN I-LF
+; PUNCT O
+SD NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviations NOUN I-LF
+. PUNCT O
+
+OUD PROPN B-AC
+, PUNCT O
+opioid NOUN B-LF
+use NOUN I-LF
+disorder NOUN I-LF
+. PUNCT O
+
+Since SCONJ O
+their PRON O
+introduction NOUN O
+in ADP O
+2009 NUM O
+, PUNCT O
+the DET O
+proportion NOUN O
+of ADP O
+direct ADJ B-LF
+oral ADJ I-LF
+anticoagulants NOUN I-LF
+( PUNCT O
+DOAC PROPN B-AC
+) PUNCT O
+is AUX O
+increasing VERB O
+constantly ADV O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+It PRON O
+has AUX O
+been AUX O
+reported VERB O
+that SCONJ O
+SJS PROPN B-AC
+/ SYM O
+TEN PROPN B-AC
+lesions NOUN O
+display VERB O
+a DET O
+mixed ADJ O
+Th1/ NOUN B-AC
+T PROPN B-LF
+helper NOUN I-LF
+type-2 NOUN I-LF
+( PUNCT O
+Th2 PROPN B-AC
+) PUNCT O
+pattern NOUN O
+[ PUNCT O
+38 NUM O
+] PUNCT O
+. PUNCT O
+
+* PUNCT O
+-refer VERB O
+to ADP O
+text NOUN O
+for ADP O
+detailed ADJ O
+summary NOUN O
+of ADP O
+visual ADJ O
+impairment/ NOUN O
+blindness NOUN O
+definitions NOUN O
+PXF- NOUN B-AC
+Pseudoexfoliation NOUN O
+; PUNCT O
+OHT NOUN B-AC
+- PUNCT O
+Ocular NOUN B-LF
+hypertension NOUN I-LF
+; PUNCT O
+PXG NOUN B-AC
+- PUNCT O
+Pseudoexfoliation NOUN B-LF
+glaucoma NOUN I-LF
+
+Mostly ADV O
+Upper ADJ B-LF
+respiratory ADJ I-LF
+tract NOUN I-LF
+infection NOUN I-LF
+( PUNCT O
+URTI PROPN B-AC
+) PUNCT O
+, PUNCT O
+Pneumonia NOUN O
+and CCONJ O
+acute ADJ O
+watery ADJ O
+diarrhea NOUN O
+received VERB O
+antibiotic ADJ O
+prescription NOUN O
+. PUNCT O
+
+Toll NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptors NOUN I-LF
+( PUNCT O
+TLRs PROPN B-AC
+) PUNCT O
+are AUX O
+a DET O
+class NOUN O
+of ADP O
+proteins NOUN O
+that PRON O
+play VERB O
+a DET O
+key ADJ O
+role NOUN O
+in ADP O
+the DET O
+innate ADJ O
+immune ADJ O
+system NOUN O
+. PUNCT O
+
+Most ADJ O
+circulating VERB O
+vitamin NOUN O
+D NOUN O
+is AUX O
+bound VERB O
+to ADP O
+vitamin NOUN B-LF
+D NOUN I-LF
+- VERB I-LF
+binding VERB I-LF
+protein NOUN I-LF
+( PUNCT O
+VDBP NOUN B-AC
+) PUNCT O
+( PUNCT O
+85~90 NUM O
+% PUNCT O
+) PUNCT O
+or CCONJ O
+albumin NOUN O
+( PUNCT O
+10~15 NUM O
+% PUNCT O
+) PUNCT O
+. PUNCT O
+
+Small ADJ B-LF
+ubiquitin NOUN I-LF
+- ADV I-LF
+like ADJ I-LF
+modifiers NOUN I-LF
+( PUNCT O
+SUMOs PROPN B-AC
+) PUNCT O
+conjugate VERB O
+to ADP O
+proteins NOUN O
+post ADV O
+- ADV O
+translationally ADV O
+, PUNCT O
+thereby ADV O
+affecting VERB O
+target NOUN O
+localization NOUN O
+, PUNCT O
+activity NOUN O
+and CCONJ O
+stability NOUN O
+. PUNCT O
+
+6 NUM B-LF
+- PUNCT I-LF
+bromoindirubin-3`-oxime NOUN I-LF
+( PUNCT O
+BIO PROPN B-AC
+) PUNCT O
+was AUX O
+purchased VERB O
+from ADP O
+Wako PROPN O
+( PUNCT O
+Japan PROPN O
+) PUNCT O
+. PUNCT O
+
+Lipoprotein NOUN B-LF
+- PUNCT I-LF
+deficient ADJ I-LF
+serum NOUN I-LF
+( PUNCT O
+LPDS PROPN B-AC
+) PUNCT O
+was AUX O
+prepared VERB O
+from ADP O
+FBS PROPN B-AC
+by ADP O
+ultracentrifugation NOUN O
+at ADP O
+a DET O
+density NOUN O
+of ADP O
+1.21 NUM O
+kg NOUN O
+/ SYM O
+L. NOUN O
+
+LFP PROPN B-AC
+, PUNCT O
+local ADJ B-LF
+field NOUN I-LF
+potential NOUN I-LF
+; PUNCT O
+MUA PROPN B-AC
+, PUNCT O
+multi ADJ B-LF
+- ADJ I-LF
+unit ADJ I-LF
+activity NOUN I-LF
+. PUNCT O
+
+The DET O
+topic NOUN O
+of ADP O
+the DET O
+end NOUN B-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+life NOUN I-LF
+( PUNCT O
+EOL PROPN B-AC
+) PUNCT O
+healthcare NOUN O
+costs NOUN O
+for ADP O
+cancer NOUN O
+patients NOUN O
+has AUX O
+been AUX O
+frequently ADV O
+discussed VERB O
+and CCONJ O
+researched VERB O
+primarily ADV O
+using VERB O
+health NOUN O
+administrative ADJ O
+data NOUN O
+since SCONJ O
+2000 NUM O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+This PRON O
+is AUX O
+a DET O
+meta NOUN O
+- NOUN O
+research NOUN O
+study NOUN O
+investigating VERB O
+the DET O
+evolution NOUN O
+of ADP O
+the DET O
+quality NOUN O
+of ADP O
+reporting NOUN O
+and CCONJ O
+key ADJ O
+methods NOUN O
+of ADP O
+randomized VERB B-LF
+controlled ADJ I-LF
+trials NOUN I-LF
+( PUNCT O
+RCTs NOUN B-AC
+) PUNCT O
+using VERB O
+meta NOUN O
+- NOUN O
+data NOUN O
+from ADP O
+a DET O
+huge ADJ O
+number NOUN O
+of ADP O
+published VERB O
+RCTs NOUN B-AC
+. PUNCT O
+To PART O
+handle VERB O
+such DET O
+an DET O
+impressive ADJ O
+number NOUN O
+of ADP O
+articles NOUN O
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+175,000 NUM O
+) PUNCT O
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+. PUNCT O
+
+Humanity NOUN O
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+unprecedented ADJ O
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+— PUNCT O
+the DET O
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+acute ADJ I-LF
+respiratory ADJ I-LF
+syndrome NOUN I-LF
+coronavirus NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+causes VERB O
+a DET O
+severe ADJ O
+respiratory ADJ O
+illness NOUN O
+— PUNCT O
+coronavirus NOUN O
+disease NOUN O
+2019 NUM O
+( PUNCT O
+COVID-19 NOUN O
+) PUNCT O
+pandemic NOUN O
+. PUNCT O
+
+Tikur PROPN B-LF
+Anbessa PROPN I-LF
+Specialized PROPN I-LF
+Hospital PROPN I-LF
+( PUNCT O
+TASH PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
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+, PUNCT O
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+, PUNCT O
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+
+The DET O
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+- PUNCT O
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+column NOUN O
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+with ADP O
+acetyl NOUN B-AC
+- PUNCT B-AC
+CoA NOUN B-AC
+( PUNCT O
+Sigma PROPN O
+, PUNCT O
+A2056 NUM O
+) PUNCT O
+and CCONJ O
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+A NOUN I-LF
+( PUNCT O
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+, PUNCT O
+C3144 NUM O
+) PUNCT O
+. PUNCT O
+
+( PUNCT O
+A X O
+) PUNCT O
+RFS PROPN B-AC
+stratified VERB O
+by ADP O
+baseline ADJ O
+ctDNA PROPN B-AC
+MAF PROPN B-AC
+quartiles NOUN O
+; PUNCT O
+MAF PROPN B-AC
+cut NOUN O
+- PUNCT O
+offs NOUN O
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+, PUNCT O
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+, PUNCT O
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+> SYM O
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+≤ SYM O
+7.2 NUM O
+, PUNCT O
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+> SYM O
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+. PUNCT O
+( PUNCT O
+B X O
+) PUNCT O
+Swimmer ADJ O
+plot NOUN O
+showing VERB O
+serial ADJ O
+ctDNA PROPN B-AC
+detectability NOUN O
+and CCONJ O
+clinical ADJ O
+outcomes NOUN O
+for ADP O
+patients NOUN O
+in ADP O
+cohort NOUN O
+1 NUM O
+and CCONJ O
+2 NUM O
+. PUNCT O
+( PUNCT O
+C X O
+) PUNCT O
+RFS PROPN B-AC
+according VERB O
+to ADP O
+serial ADJ O
+baseline ADJ O
+and CCONJ O
+postoperative ADJ O
+ctDNA PROPN B-AC
+status NOUN O
+. PUNCT O
+ctDNA PROPN B-AC
+, PUNCT O
+circulating VERB B-LF
+tumor NOUN I-LF
+DNA NOUN I-LF
+; PUNCT O
+MAF PROPN B-AC
+, PUNCT O
+mutant ADJ B-LF
+allele NOUN I-LF
+fraction NOUN I-LF
+; PUNCT O
+RFS PROPN B-AC
+, PUNCT O
+recurrence NOUN B-LF
+- PUNCT I-LF
+free ADJ I-LF
+survival NOUN I-LF
+. PUNCT O
+
+Eugonadal ADJ O
+men NOUN O
+with ADP O
+iron NOUN B-LF
+- PUNCT I-LF
+deficiency NOUN I-LF
+anemia NOUN I-LF
+( PUNCT O
+IDA PROPN B-AC
+) PUNCT O
+who PRON O
+received VERB O
+intravenous ADJ O
+iron NOUN O
+therapy NOUN O
+( PUNCT O
+800~1200 NUM O
+mg NOUN O
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+) PUNCT O
+for ADP O
+12 NUM O
+weeks NOUN O
+exhibited VERB O
+increased VERB O
+levels NOUN O
+of ADP O
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+, PUNCT O
+luteinizing VERB B-LF
+hormone NOUN I-LF
+( PUNCT O
+LH PROPN B-AC
+) PUNCT O
+, PUNCT O
+follicle NOUN B-LF
+- PUNCT I-LF
+stimulating VERB I-LF
+hormone NOUN I-LF
+( PUNCT O
+FSH PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+sperm NOUN O
+parameters NOUN O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
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+, PUNCT O
+diabetes NOUN B-LF
+type NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+DM2 NOUN B-AC
+, PUNCT O
+diabetes NOUN B-LF
+type NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+GDM NOUN B-AC
+, PUNCT O
+gestational ADJ B-LF
+diabetes NOUN I-LF
+; PUNCT O
+OR NOUN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+PE NOUN B-AC
+, PUNCT O
+preeclampsia NOUN B-LF
+; PUNCT O
+PGDM NOUN B-AC
+, PUNCT O
+pregestational ADJ O
+diabetes NOUN O
+; PUNCT O
+PR NOUN B-AC
+, PUNCT O
+prevalence NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+RR PROPN B-AC
+, PUNCT O
+risk NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+HF PROPN B-AC
+entry NOUN O
+into ADP O
+anagen PROPN O
+requires VERB O
+the DET O
+activation NOUN O
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+HF PROPN B-AC
+- PUNCT B-AC
+SCs NOUN B-AC
+and CCONJ O
+of ADP O
+progenitors NOUN O
+located VERB O
+in ADP O
+the DET O
+secondary ADJ O
+hair NOUN B-LF
+germ NOUN I-LF
+( PUNCT O
+HG PROPN B-AC
+) PUNCT O
+that PRON O
+expand VERB O
+to ADP O
+give VERB O
+rise NOUN O
+to ADP O
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+new ADJ O
+anagen PROPN O
+HF PROPN B-AC
+[ X O
+17]–[19 X O
+] PUNCT O
+. PUNCT O
+
+DIC PROPN B-AC
+, PUNCT O
+decline NOUN B-LF
+in ADP I-LF
+intrinsic ADJ I-LF
+capacity NOUN I-LF
+; PUNCT O
+ICD PROPN O
+-0 NUM O
+, PUNCT O
+International PROPN O
+Classification PROPN O
+of ADP O
+Diseases–10thRevision PROPN O
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+. PUNCT O
+
+synthetic ADJ B-LF
+UniSp6 PROPN I-LF
+RNA NOUN I-LF
+spike NOUN I-LF
+- PUNCT I-LF
+in NOUN I-LF
+
+RT NOUN B-AC
+- PUNCT B-AC
+qPCR NOUN B-AC
+, PUNCT O
+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+PCR NOUN I-LF
+. PUNCT O
+
+The DET O
+National PROPN B-LF
+Lung PROPN I-LF
+Screening PROPN I-LF
+Trial PROPN I-LF
+( PUNCT O
+NLST PROPN B-AC
+) PUNCT O
+showed VERB O
+that SCONJ O
+screening NOUN O
+with ADP O
+low ADJ O
+- PUNCT O
+dose NOUN O
+computed VERB B-LF
+tomography NOUN I-LF
+( PUNCT O
+CT NOUN B-AC
+) PUNCT O
+can AUX O
+reduce VERB O
+lung NOUN O
+cancer NOUN O
+mortality NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+pRNFL PROPN B-AC
+: PUNCT O
+peripapillary ADJ B-LF
+retinal ADJ I-LF
+nerve NOUN I-LF
+fiber NOUN I-LF
+layer NOUN I-LF
+; PUNCT O
+TML PROPN B-AC
+: PUNCT O
+total ADJ B-LF
+macular ADJ I-LF
+layer NOUN I-LF
+; PUNCT O
+mRNFL PROPN B-AC
+: PUNCT O
+macular ADJ B-LF
+retinal ADJ I-LF
+nerve NOUN I-LF
+fiber NOUN I-LF
+layer NOUN I-LF
+; PUNCT O
+mGCL PROPN B-AC
+: PUNCT O
+macular ADJ B-LF
+ganglion NOUN I-LF
+cell NOUN I-LF
+layer NOUN I-LF
+; PUNCT O
+Temp NOUN O
+- PUNCT O
+sup NOUN O
+: PUNCT O
+temporal ADJ O
+- PUNCT O
+superior ADJ O
+; PUNCT O
+Temp NOUN O
+- PUNCT O
+inf NOUN O
+: PUNCT O
+temporal ADJ O
+- PUNCT O
+inferior ADJ O
+; PUNCT O
+Nas NOUN O
+- PUNCT O
+sup NOUN O
+: PUNCT O
+nasal ADJ O
+- PUNCT O
+superior ADJ O
+; PUNCT O
+Nas NOUN O
+- PUNCT O
+inf NOUN O
+: PUNCT O
+nasal ADJ O
+- PUNCT O
+inferior ADJ O
+; PUNCT O
+SIM PROPN B-AC
+: PUNCT O
+superior ADJ O
+inner ADJ O
+macula NOUN O
+; PUNCT O
+IIM PROPN B-AC
+: PUNCT O
+inferior ADJ O
+inner ADJ O
+macula NOUN O
+; PUNCT O
+SOM PROPN B-AC
+: PUNCT O
+superior ADJ O
+outer ADJ O
+macula NOUN O
+; PUNCT O
+IOM PROPN B-AC
+: PUNCT O
+inferior ADJ O
+outer ADJ O
+macula NOUN O
+; PUNCT O
+AUROC PROPN B-AC
+: PUNCT O
+area NOUN O
+under ADP O
+the DET O
+receiver NOUN O
+operating NOUN O
+characteristic NOUN O
+; PUNCT O
+CI PROPN O
+: PUNCT O
+confidence NOUN O
+interval NOUN O
+. PUNCT O
+
+CAA PROPN B-AC
+, PUNCT O
+casamino NOUN B-LF
+acid NOUN I-LF
+medium NOUN I-LF
+; PUNCT O
+CAS PROPN B-AC
+, PUNCT O
+casein NOUN B-LF
+medium NOUN I-LF
+; PUNCT O
+CFU PROPN O
+, PUNCT O
+colony NOUN O
+forming VERB O
+units NOUN O
+; PUNCT O
+LB PROPN B-AC
+, PUNCT O
+Lysogeny PROPN B-LF
+broth NOUN I-LF
+; PUNCT O
+OD600 PROPN B-AC
+, PUNCT O
+optical ADJ B-LF
+density NOUN I-LF
+at ADP I-LF
+600 NUM I-LF
+nm NOUN I-LF
+. PUNCT O
+
+Sections NOUN O
+were AUX O
+blocked VERB O
+with ADP O
+5 NUM O
+% NOUN O
+donkey NOUN O
+- ADJ O
+serum NOUN O
+(= PUNCT O
+host NOUN O
+of ADP O
+secondary ADJ O
+antibody NOUN B-LF
+, PUNCT O
+Sigma PROPN O
+) PUNCT O
+for ADP O
+30 NUM O
+min NOUN O
+at ADP O
+room NOUN B-LF
+temperature NOUN I-LF
+( PUNCT O
+RT PROPN B-AC
+) PUNCT O
+and CCONJ O
+incubated VERB O
+with ADP O
+primary ADJ O
+antibodies NOUN O
+( PUNCT O
+AB PROPN B-AC
+) PUNCT O
+for ADP O
+insulin NOUN O
+( PUNCT O
+C27C9 NOUN O
+) PUNCT O
+or CCONJ O
+glucagon NOUN O
+( PUNCT O
+D16G10 NOUN O
+, PUNCT O
+both PRON O
+rabbit ADJ O
+monoclonal ADJ O
+AB PROPN B-AC
+, PUNCT O
+Cell PROPN O
+Signaling PROPN O
+, PUNCT O
+Cambridge PROPN O
+, PUNCT O
+UK PROPN O
+) PUNCT O
+for ADP O
+60 NUM O
+min NOUN O
+at ADP O
+RT PROPN B-AC
+. PUNCT O
+Slides NOUN O
+were AUX O
+washed VERB O
+thrice ADV O
+and CCONJ O
+incubated VERB O
+with ADP O
+secondary ADJ O
+AB PROPN B-AC
+( PUNCT O
+711 NUM O
+- ADJ O
+035 NUM O
+- ADJ O
+152 NUM O
+, PUNCT O
+donkey NOUN O
+anti ADJ O
+- ADJ O
+rabbit ADJ O
+polyclonal ADJ O
+AB PROPN B-AC
+, PUNCT O
+Dianova PROPN O
+, PUNCT O
+Hamburg PROPN O
+, PUNCT O
+Germany PROPN O
+) PUNCT O
+for ADP O
+30 NUM O
+min NOUN O
+at ADP O
+RT PROPN B-AC
+. PUNCT O
+Staining NOUN O
+was AUX O
+performed VERB O
+with ADP O
+DAB PROPN O
+Peroxidase PROPN O
+Substrate PROPN O
+Kit PROPN O
+( PUNCT O
+Liquid PROPN O
+DAB+Substrate PROPN O
+Chromogen PROPN O
+System PROPN O
+, PUNCT O
+Dako PROPN O
+) PUNCT O
+, PUNCT O
+following VERB O
+instructions NOUN O
+of ADP O
+the DET O
+manufacturer NOUN O
+. PUNCT O
+
+TEM NOUN B-AC
+, PUNCT O
+transmission NOUN B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+. PUNCT O
+
+We PRON O
+reasoned VERB O
+that SCONJ O
+impaired ADJ O
+snRNA NOUN O
+3′ NUM O
+end NOUN O
+cleavage NOUN O
+should AUX O
+increase VERB O
+the DET O
+levels NOUN O
+of ADP O
+pre ADJ B-AC
+- PUNCT B-AC
+snRNAs NOUN B-AC
+. PUNCT O
+From ADP O
+~ NUM O
+500 NUM O
+T NOUN O
+- PUNCT O
+DNA NOUN O
+insertion NOUN O
+lines NOUN O
+, PUNCT O
+we PRON O
+identified VERB O
+a DET O
+mutant NOUN O
+( PUNCT O
+Salk_036641C NOUN O
+) PUNCT O
+containing VERB O
+elevated ADJ O
+levels NOUN O
+of ADP O
+pre ADJ O
+- PUNCT O
+U2.3 ADJ O
+snRNA NOUN O
+relative ADJ O
+to ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+plants NOUN O
+( PUNCT O
+WT PROPN B-AC
+; PUNCT O
+Columbia-0 PROPN B-LF
+[ SYM O
+Col PROPN B-AC
+] PUNCT O
+) PUNCT O
+through ADP O
+reverse ADJ B-LF
+transcription NOUN I-LF
+PCR PROPN I-LF
+( PUNCT O
+RT PROPN B-AC
+- PUNCT B-AC
+PCR PROPN B-AC
+) PUNCT O
+analyses NOUN O
+( PUNCT O
+Fig PROPN O
+1A NOUN O
+and CCONJ O
+S1 PROPN O
+Data PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+clade NOUN O
+B PROPN O
+New PROPN B-LF
+World PROPN I-LF
+arenaviruses NOUN I-LF
+( PUNCT O
+NWAs PROPN B-AC
+) PUNCT O
+, PUNCT O
+including VERB O
+Junín PROPN O
+and CCONJ O
+Machupo PROPN O
+viruses NOUN O
+— PUNCT O
+the DET O
+causative ADJ O
+agents NOUN O
+of ADP O
+Argentine ADJ O
+and CCONJ O
+Bolivian ADJ O
+hemorrhagic ADJ O
+fever NOUN O
+, PUNCT O
+respectively ADV O
+— PUNCT O
+use VERB O
+human ADJ O
+but CCONJ O
+not PART O
+mouse NOUN O
+( PUNCT O
+Mus PROPN O
+) PUNCT O
+transferrin NOUN B-LF
+receptor NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+TfR1 PROPN B-AC
+) PUNCT O
+for ADP O
+cell NOUN O
+entry NOUN O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+, PUNCT O
+whereas SCONJ O
+the DET O
+Old PROPN B-LF
+World PROPN I-LF
+arenaviruses NOUN I-LF
+( PUNCT O
+OWAs PROPN B-AC
+) PUNCT O
+Lassa PROPN O
+virus NOUN O
+and CCONJ O
+lymphocytic ADJ B-LF
+choriomeningitis NOUN I-LF
+virus NOUN I-LF
+( PUNCT O
+LCMV PROPN B-AC
+) PUNCT O
+use VERB O
+alpha NOUN O
+- PUNCT O
+dystroglycan NOUN O
+[ PUNCT O
+3 NUM O
+] PUNCT O
+. PUNCT O
+
+Anc PROPN O
+, PUNCT O
+ancestral ADJ O
+lys− NOUN O
+strain NOUN O
+; PUNCT O
+ECM21 PROPN B-AC
+, PUNCT O
+extracellular ADJ B-LF
+mutant NOUN I-LF
+gene NOUN I-LF
+21 NUM I-LF
+; PUNCT O
+Evo PROPN O
+, PUNCT O
+an DET O
+evolved VERB O
+lys− NOUN O
+strain NOUN O
+; PUNCT O
+GSH PROPN B-AC
+, PUNCT O
+reduced VERB B-LF
+glutathione NOUN I-LF
+; PUNCT O
+HPLC PROPN B-AC
+, PUNCT O
+High PROPN B-LF
+- PUNCT I-LF
+Performance PROPN I-LF
+Liquid PROPN I-LF
+Chromatography PROPN I-LF
+; PUNCT O
+lys− NOUN O
+, PUNCT O
+lysine NOUN O
+- PUNCT O
+requiring VERB O
+mutant NOUN O
+; PUNCT O
+T2 PROPN O
+, PUNCT O
+doubling VERB O
+time NOUN O
+. PUNCT O
+
+The DET O
+incidence NOUN O
+of ADP O
+surgery NOUN O
+- PUNCT O
+related VERB O
+AE PROPN B-AC
+- PUNCT B-AC
+IPF PROPN B-AC
+or CCONJ O
+acute ADJ B-LF
+respiratory ADJ I-LF
+distress NOUN I-LF
+syndrome NOUN I-LF
+( PUNCT O
+ARDS PROPN B-AC
+) PUNCT O
+was AUX O
+significantly ADV O
+higher ADJ O
+in ADP O
+the DET O
+LC PROPN B-AC
+with ADP O
+IPF PROPN B-AC
+group NOUN O
+than ADP O
+in ADP O
+the DET O
+LC PROPN B-AC
+without ADP O
+IPF PROPN B-AC
+group NOUN O
+. PUNCT O
+
+Here ADV O
+we PRON O
+use VERB O
+all DET O
+- PUNCT O
+atom NOUN O
+molecular ADJ B-LF
+dynamics NOUN I-LF
+( PUNCT O
+MD NOUN B-AC
+) PUNCT O
+simulations NOUN O
+to PART O
+study VERB O
+transport NOUN O
+of ADP O
+single ADJ O
+cations NOUN O
+through ADP O
+the DET O
+charge NOUN O
+- PUNCT O
+selective ADJ O
+channel NOUN O
+of ADP O
+the DET O
+nicotinic ADJ B-LF
+acetylcholine NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+nAChR PROPN B-AC
+) PUNCT O
+from ADP O
+the DET O
+motor NOUN O
+endplate NOUN O
+. PUNCT O
+
+Anthropometric ADJ O
+and CCONJ O
+metabolic ADJ O
+risk NOUN O
+factors NOUN O
+for ADP O
+all DET O
+- PUNCT O
+cause NOUN O
+end NOUN B-LF
+- PUNCT I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD PROPN B-AC
+) PUNCT O
+may AUX O
+vary VERB O
+in ADP O
+their PRON O
+impact NOUN O
+depending VERB O
+on ADP O
+the DET O
+specific ADJ O
+primary ADJ O
+renal ADJ O
+disease NOUN O
+. PUNCT O
+
+FAME PROPN B-AC
+, PUNCT O
+fatty ADJ B-LF
+acid NOUN I-LF
+methyl NOUN I-LF
+ester NOUN I-LF
+; PUNCT O
+M PROPN O
+/ PROPN O
+LCFA PROPN B-AC
+, PUNCT O
+medium- ADJ O
+and CCONJ O
+long ADJ B-LF
+- PUNCT I-LF
+chain NOUN I-LF
+fatty ADJ I-LF
+acid NOUN I-LF
+; PUNCT O
+NEFA PROPN B-AC
+, PUNCT O
+nonesterified ADJ B-LF
+fatty ADJ I-LF
+acid NOUN I-LF
+; PUNCT O
+Pex PROPN O
+, PUNCT O
+peroxin NOUN O
+; PUNCT O
+TMRE PROPN B-AC
+, PUNCT O
+tetramethylrhodamine NOUN B-LF
+ethyl NOUN I-LF
+ester NOUN I-LF
+. PUNCT O
+
+Abnormal ADJ O
+RVOT PROPN B-AC
+was AUX O
+defined VERB O
+as ADP O
+the DET O
+presence NOUN O
+of ADP O
+RVOT PROPN B-AC
+regional ADJ B-LF
+wall NOUN I-LF
+motion NOUN I-LF
+abnormalities NOUN I-LF
+( PUNCT O
+RWMA PROPN B-AC
+; PUNCT O
+defined VERB O
+as ADP O
+akinesis NOUN O
+, PUNCT O
+dyskinesis NOUN O
+) PUNCT O
+or CCONJ O
+an DET O
+RVOT PROPN B-AC
+diameter NOUN O
+> ADP O
+25mm[22 NUM O
+] PUNCT O
+. PUNCT O
+
+MIHR PROPN B-AC
+, PUNCT O
+MIH PROPN B-LF
+receptor NOUN I-LF
+. PUNCT O
+
+Lipid NOUN O
+membranes NOUN O
+were AUX O
+prepared VERB O
+from ADP O
+cholesterol NOUN B-LF
+( PUNCT O
+CHOL PROPN B-AC
+) PUNCT O
+, PUNCT O
+1 NUM B-LF
+- PUNCT I-LF
+palmitoyl-2 NOUN I-LF
+- PUNCT I-LF
+oleoyl NOUN I-LF
+- PUNCT I-LF
+sn NOUN I-LF
+- PUNCT I-LF
+glycero-3 NOUN I-LF
+- PUNCT I-LF
+phospho NOUN I-LF
+- PUNCT I-LF
+L NOUN I-LF
+- PUNCT I-LF
+serine NOUN I-LF
+( PUNCT O
+POPS PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+1,2 NUM B-LF
+- PUNCT I-LF
+dipalmitoyl NOUN I-LF
+- PUNCT I-LF
+sn NOUN I-LF
+- PUNCT I-LF
+glycero-3 NOUN I-LF
+- PUNCT I-LF
+phosphocholine NOUN I-LF
+( PUNCT O
+PC PROPN B-AC
+) PUNCT O
+at ADP O
+1:7:2 NUM O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+AhR PROPN B-AC
+activation NOUN O
+increases VERB O
+detoxification NOUN O
+to PART O
+protect VERB O
+the DET O
+organism NOUN O
+from ADP O
+xenobiotic ADJ O
+exposure NOUN O
+by ADP O
+influencing VERB O
+the DET O
+gene NOUN O
+expression NOUN O
+and CCONJ O
+activity NOUN O
+of ADP O
+efflux ADJ O
+transporters NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+the DET O
+ABCG2 PROPN B-AC
+transporter NOUN O
+( PUNCT O
+ATP NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+cassette NOUN I-LF
+subfamily NOUN I-LF
+G PROPN I-LF
+2 NUM I-LF
+, PUNCT O
+Breast PROPN B-LF
+Cancer PROPN I-LF
+Resistance PROPN I-LF
+Protein PROPN I-LF
+, PUNCT O
+BCRP PROPN B-AC
+) PUNCT O
+[ PUNCT O
+11,16–18 NUM O
+] PUNCT O
+. PUNCT O
+
+Physical ADJ B-LF
+activity NOUN I-LF
+( PUNCT O
+PA NOUN B-AC
+) PUNCT O
+and CCONJ O
+diet NOUN O
+are AUX O
+the DET O
+modifiable ADJ O
+lifestyle NOUN O
+behaviors NOUN O
+that PRON O
+play VERB O
+significant ADJ O
+roles NOUN O
+in ADP O
+achieving VERB O
+and CCONJ O
+maintaining VERB O
+energy NOUN O
+balance NOUN O
+for ADP O
+both CCONJ O
+treatment NOUN O
+and CCONJ O
+prevention NOUN O
+of ADP O
+obesity NOUN O
+[ PUNCT O
+7,8 NUM O
+] PUNCT O
+. PUNCT O
+
+Ark1 PROPN O
+, PUNCT O
+aurora NOUN O
+- PUNCT O
+related VERB O
+kinase NOUN O
+1 NUM O
+; PUNCT O
+Brca1 PROPN B-AC
+, PUNCT O
+breast NOUN B-LF
+cancer NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+susceptibility NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+Cep112 PROPN B-AC
+, PUNCT O
+centrosomal ADJ B-LF
+protein NOUN I-LF
+112 NUM I-LF
+; PUNCT O
+Gapdh PROPN O
+, PUNCT O
+glyceride NOUN O
+3 NUM O
+- PUNCT O
+phosphate NOUN O
+dehydrogenase NOUN O
+; PUNCT O
+siRNA NOUN O
+, PUNCT O
+small ADJ O
+interfering VERB O
+RNA NOUN O
+. PUNCT O
+
+We PRON O
+evaluated VERB O
+the DET O
+assay NOUN O
+precision NOUN O
+, PUNCT O
+according VERB O
+to ADP O
+the DET O
+guideline NOUN O
+of ADP O
+The PRON B-LF
+Clinical PROPN I-LF
+& CCONJ I-LF
+Laboratory PROPN I-LF
+Standards PROPN I-LF
+Institute PROPN I-LF
+( PUNCT O
+CLSI PROPN B-AC
+) PUNCT O
+documents NOUN O
+EP15 PROPN O
+- SYM O
+A3 NOUN O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+Understanding VERB O
+geographic ADJ O
+inequalities NOUN O
+in ADP O
+coverage NOUN O
+of ADP O
+drinking NOUN O
+- PUNCT O
+water NOUN B-LF
+supply NOUN I-LF
+and CCONJ I-LF
+sanitation NOUN I-LF
+( PUNCT O
+WSS PROPN B-AC
+) PUNCT O
+will AUX O
+help VERB O
+track VERB O
+progress NOUN O
+towards ADP O
+universal ADJ O
+coverage NOUN O
+of ADP O
+water NOUN O
+and CCONJ O
+sanitation NOUN O
+by ADP O
+identifying VERB O
+marginalized VERB O
+populations NOUN O
+, PUNCT O
+thus ADV O
+helping VERB O
+to PART O
+control VERB O
+a DET O
+large ADJ O
+number NOUN O
+of ADP O
+infectious ADJ O
+diseases NOUN O
+. PUNCT O
+
+Brca1 PROPN B-AC
+, PUNCT O
+breast NOUN B-LF
+cancer NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+susceptibility NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+Cep112 PROPN B-AC
+, PUNCT O
+centrosomal ADJ B-LF
+protein NOUN I-LF
+112 NUM I-LF
+; PUNCT O
+FAM PROPN B-AC
+, PUNCT O
+fluorescein NOUN B-LF
+amidite NOUN I-LF
+; PUNCT O
+Ginir PROPN B-AC
+, PUNCT O
+Genomic PROPN B-LF
+Instability PROPN I-LF
+Inducing PROPN I-LF
+RNA NOUN I-LF
+; PUNCT O
+IgG PROPN O
+, PUNCT O
+immunoglobulin NOUN O
+G PROPN O
+; PUNCT O
+IP PROPN O
+, PUNCT O
+immunoprecipitation NOUN O
+; PUNCT O
+RIP PROPN B-AC
+, PUNCT O
+RNA NOUN B-LF
+- PUNCT I-LF
+immunoprecipitation NOUN I-LF
+; PUNCT O
+RNasin PROPN B-AC
+, PUNCT O
+RNase NOUN B-LF
+inhibitor NOUN I-LF
+; PUNCT O
+RT PROPN B-AC
+- PUNCT B-AC
+PCR PROPN B-AC
+, PUNCT O
+reverse ADJ O
+transcription NOUN O
+polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+; PUNCT O
+snRNA NOUN B-AC
+, PUNCT O
+small ADJ B-LF
+nuclear ADJ I-LF
+RNA NOUN I-LF
+. PUNCT O
+
+COPD NOUN B-AC
+= VERB O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+e NOUN O
+= VERB O
+exacerbations NOUN O
+. PUNCT O
+
+Several ADJ O
+U.S. PROPN O
+based VERB O
+studies NOUN O
+report NOUN O
+treatment NOUN O
+rates NOUN O
+with ADP O
+pegylated NOUN B-LF
+- PUNCT I-LF
+interferon NOUN I-LF
+( PUNCT O
+PEG PROPN B-AC
+- PUNCT B-AC
+IFN PROPN B-AC
+) PUNCT O
+and CCONJ O
+ribavirin NOUN B-LF
+( PUNCT O
+RBV PROPN B-AC
+) PUNCT O
+that SCONJ O
+range VERB O
+from ADP O
+nine NUM O
+to ADP O
+36%.[3–7 NUM O
+] PUNCT O
+In ADP O
+their PRON O
+report NOUN O
+the DET O
+WHO PROPN B-AC
+also ADV O
+estimates VERB O
+that SCONJ O
+under ADP O
+1 NUM O
+% NOUN O
+of ADP O
+treatment NOUN O
+eligible ADJ O
+CHC PROPN B-AC
+patients NOUN O
+worldwide ADV O
+have AUX O
+received VERB O
+antiviral ADJ O
+therapy.[2 NOUN O
+] PUNCT O
+
+Next ADV O
+, PUNCT O
+the DET O
+diabetic ADJ O
+rats NOUN O
+were AUX O
+randomly ADV O
+divided VERB O
+into ADP O
+three NUM O
+groups NOUN O
+: PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+( PUNCT O
+DM PROPN B-AC
+) PUNCT O
+group NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+6 NUM O
+) PUNCT O
+, PUNCT O
+Ad PROPN O
+- PUNCT O
+Sik1 PROPN O
+group NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+8) NUM O
+, PUNCT O
+and CCONJ O
+Ad PROPN B-AC
+- PUNCT B-AC
+GFP PROPN B-AC
+group NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+6 NUM O
+) PUNCT O
+. PUNCT O
+
+There PRON O
+are VERB O
+two NUM O
+previously ADV O
+reported VERB O
+transcription NOUN O
+factors NOUN O
+that PRON O
+utilize VERB O
+Prox1 PROPN O
+as ADP O
+co NOUN O
+- NOUN O
+repressor NOUN O
+via ADP O
+direct ADJ O
+interactions NOUN O
+to ADP O
+suppress VERB O
+gene NOUN O
+expression NOUN O
+in ADP O
+other ADJ O
+systems NOUN O
+, PUNCT O
+NR5A2 PROPN B-AC
+( PUNCT O
+Nuclear PROPN B-LF
+Receptor PROPN I-LF
+5A2 PROPN I-LF
+) PUNCT O
+and CCONJ O
+SF1 PROPN B-AC
+( PUNCT O
+Steroidogenic PROPN B-LF
+Factor PROPN I-LF
+1 NUM I-LF
+) PUNCT O
+, PUNCT O
+both PRON O
+belonging VERB O
+to ADP O
+the DET O
+family NOUN O
+of ADP O
+orphan ADJ O
+nuclear ADJ O
+receptors NOUN O
+[ X O
+34]–[36 X O
+] PUNCT O
+. PUNCT O
+
+Data NOUN O
+on ADP O
+age NOUN O
+, PUNCT O
+sex NOUN O
+, PUNCT O
+and CCONJ O
+SNAP PROPN B-AC
+participation NOUN O
+status NOUN O
+were AUX O
+acquired VERB O
+from ADP O
+the DET O
+National PROPN B-LF
+Health PROPN I-LF
+Interview PROPN I-LF
+Survey PROPN I-LF
+( PUNCT O
+NHIS PROPN B-AC
+) PUNCT O
+, PUNCT O
+2000–2009 NUM O
+. PUNCT O
+
+Orthologs NOUN O
+contrast VERB O
+to ADP O
+paralogs NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+genes NOUN O
+that PRON O
+diverged VERB O
+by ADP O
+gene NOUN O
+duplication NOUN O
+, PUNCT O
+and CCONJ O
+xenologs NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+homologous ADJ O
+genes NOUN O
+whose DET O
+history NOUN O
+of ADP O
+divergence NOUN O
+includes VERB O
+one NUM O
+or CCONJ O
+more ADJ O
+horizontal ADJ B-LF
+gene NOUN I-LF
+transfer NOUN I-LF
+( PUNCT O
+HGT PROPN B-AC
+) PUNCT O
+events NOUN O
+. PUNCT O
+
+Heterogeneity NOUN B-LF
+was AUX O
+measured VERB O
+by ADP O
+I2 PROPN B-AC
+statistics NOUN O
+( PUNCT O
+I2>50 NUM B-AC
+% NOUN O
+was AUX O
+regarded VERB O
+as ADP O
+heterogeneity NOUN B-LF
+) PUNCT O
+and CCONJ O
+Q PROPN O
+statistics NOUN O
+( PUNCT O
+P<0.1 NOUN O
+was AUX O
+considered VERB O
+heterogeneity NOUN B-LF
+) PUNCT O
+. PUNCT O
+
+Representatives NOUN O
+of ADP O
+this DET O
+cluster NOUN O
+included VERB O
+Tsukushi PROPN B-LF
+( PUNCT O
+Tsku PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+a DET O
+recently ADV O
+identified VERB O
+hepatokine NOUN O
+that PRON O
+can AUX O
+regulate VERB O
+BAT NOUN B-AC
+energy NOUN O
+expenditure NOUN O
+[ PUNCT O
+32 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+Stearoyl PROPN B-LF
+- PUNCT I-LF
+Coenzyme PROPN I-LF
+A PROPN I-LF
+Desaturase PROPN I-LF
+2 NUM I-LF
+( PUNCT O
+Scd2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+required VERB O
+for ADP O
+PPARg NOUN B-AC
+expression NOUN O
+in ADP O
+3T3 NOUN O
+- PUNCT O
+L1 NOUN O
+adipose ADJ O
+cells NOUN O
+[ PUNCT O
+33 NUM O
+] PUNCT O
+. PUNCT O
+
+Class NOUN O
+IV NUM O
+md NOUN B-AC
+neurons NOUN O
+can AUX O
+be AUX O
+identified VERB O
+with ADP O
+ppkEGFP PROPN O
+, PUNCT O
+which PRON O
+labels VERB O
+one NUM O
+intersegmental ADJ B-LF
+nerve NOUN I-LF
+( PUNCT O
+ISN PROPN B-AC
+) PUNCT O
+and CCONJ O
+two NUM O
+segmental ADJ B-LF
+nerve NOUN I-LF
+( PUNCT O
+SN PROPN B-AC
+) PUNCT O
+neurons NOUN O
+in ADP O
+each DET O
+hemisegment NOUN O
+[ PUNCT O
+9],[12 NUM O
+] PUNCT O
+. PUNCT O
+
+Ct NOUN B-AC
+, PUNCT O
+cycle NOUN B-LF
+threshold NOUN I-LF
+; PUNCT O
+MuV PROPN B-AC
+, PUNCT O
+mumps NOUN B-LF
+virus NOUN I-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+qPCR PROPN B-AC
+, PUNCT O
+real ADJ B-LF
+- PUNCT I-LF
+time NOUN I-LF
+quantitative ADJ I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+utilised VERB O
+a DET O
+large ADJ O
+international ADJ O
+registry NOUN O
+[ X O
+15 NUM O
+] X O
+of ADP O
+intensive ADJ O
+care NOUN O
+admissions NOUN O
+following VERB O
+cardiac ADJ O
+arrest NOUN O
+and CCONJ O
+applied VERB O
+a DET O
+variety NOUN O
+of ADP O
+ML NOUN B-AC
+methods NOUN O
+to ADP O
+improve VERB O
+the DET O
+prediction NOUN O
+of ADP O
+outcomes NOUN O
+, PUNCT O
+and CCONJ O
+compared VERB O
+these DET O
+methods NOUN O
+with ADP O
+logistic ADJ B-LF
+regression NOUN I-LF
+( PUNCT O
+LR NOUN B-AC
+) PUNCT O
+in ADP O
+addition NOUN O
+to ADP O
+existing VERB O
+gold ADJ O
+standard NOUN O
+generic ADJ O
+ICU PROPN B-AC
+illness NOUN O
+severity NOUN O
+scores NOUN O
+. PUNCT O
+
+Nursing NOUN O
+homes NOUN O
+were AUX O
+allocated VERB O
+to ADP O
+receive VERB O
+either CCONJ O
+the DET O
+WHELD PROPN O
+intervention NOUN O
+or CCONJ O
+TAU PROPN B-AC
+using VERB O
+secure ADJ O
+web NOUN O
+access NOUN O
+to ADP O
+the DET O
+remote ADJ O
+randomisation NOUN O
+centre NOUN O
+at ADP O
+the DET O
+North PROPN B-LF
+Wales PROPN I-LF
+Organisation PROPN I-LF
+for ADP I-LF
+Randomised PROPN I-LF
+Trials PROPN I-LF
+in ADP I-LF
+Health PROPN I-LF
+Clinical PROPN I-LF
+Trial PROPN I-LF
+Unit PROPN I-LF
+( PUNCT O
+NWORTH PROPN B-AC
+CTU PROPN B-AC
+) PUNCT O
+at ADP O
+Bangor PROPN O
+University PROPN O
+. PUNCT O
+
+We PRON O
+considered VERB O
+positive ADJ O
+cytology NOUN O
+as ADP O
+: PUNCT O
+Atypical PROPN B-LF
+Squamous PROPN I-LF
+Cells PROPN I-LF
+of ADP I-LF
+Undetermined PROPN I-LF
+Significance NOUN I-LF
+( PUNCT O
+ASC PROPN B-AC
+- PUNCT B-AC
+US PROPN B-AC
+) PUNCT O
+, PUNCT O
+Atypical PROPN O
+Squamous PROPN O
+Cells PROPN O
+can AUX O
+not AUX O
+exclude VERB O
+a DET O
+High ADJ B-LF
+- PUNCT I-LF
+grade NOUN I-LF
+Squamous PROPN I-LF
+Intraepithelial PROPN I-LF
+Lesion PROPN I-LF
+( PUNCT O
+ASC PROPN B-AC
+- PUNCT B-AC
+H PROPN B-AC
+) PUNCT O
+, PUNCT O
+Low ADJ B-LF
+- PUNCT I-LF
+grade NOUN I-LF
+Squamous PROPN I-LF
+Intraepithelial PROPN I-LF
+Lesion PROPN I-LF
+( PUNCT O
+LSIL PROPN B-AC
+) PUNCT O
+, PUNCT O
+High ADJ B-LF
+- PUNCT I-LF
+grade NOUN I-LF
+Squamous PROPN I-LF
+Intraepithelial PROPN I-LF
+Lesion PROPN I-LF
+( PUNCT O
+HSIL PROPN B-AC
+) PUNCT O
+, PUNCT O
+AGC PROPN B-AC
+( PUNCT O
+Atypical PROPN B-LF
+Glandular PROPN I-LF
+Cells PROPN I-LF
+) PUNCT O
+, PUNCT O
+Atypical PROPN B-LF
+Glandular PROPN I-LF
+Cells PROPN I-LF
+favour VERB O
+neoplastic ADJ O
+, PUNCT O
+endocervical ADJ O
+adenocarcinoma NOUN O
+in ADP O
+situ NOUN O
+or CCONJ O
+adenocarcinoma NOUN O
+. PUNCT O
+
+Oxidative ADJ O
+stress NOUN O
+was AUX O
+induced VERB O
+with ADP O
+H2O2 NOUN B-AC
+for ADP O
+an DET O
+hour NOUN O
+which PRON O
+was AUX O
+followed VERB O
+by ADP O
+supplementation NOUN O
+with ADP O
+different ADJ O
+ratios NOUN O
+of ADP O
+α NOUN B-AC
+- PUNCT B-AC
+TCP NOUN B-AC
+and CCONJ O
+tocotrienol NOUN B-LF
+- PUNCT I-LF
+rich ADJ I-LF
+fraction NOUN I-LF
+( PUNCT O
+TRF NOUN B-AC
+) PUNCT O
+for ADP O
+four NUM O
+hours NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+; PUNCT O
+FLR PROPN B-AC
+: PUNCT O
+Focal ADJ B-LF
+liver NOUN I-LF
+reaction NOUN I-LF
+; PUNCT O
+PBT PROPN B-AC
+: PUNCT O
+Proton NOUN B-LF
+beam NOUN I-LF
+therapy NOUN I-LF
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+investigated VERB O
+the DET O
+distribution NOUN O
+of ADP O
+particular ADJ O
+inhibitory ADJ O
+GAG PROPN B-AC
+chains NOUN O
+and CCONJ O
+CSPG PROPN B-AC
+subtypes NOUN O
+within ADP O
+multifasciculated ADJ O
+peripheral ADJ O
+nerves NOUN O
+and CCONJ O
+their PRON O
+susceptibility NOUN O
+to ADP O
+degradation NOUN O
+and CCONJ O
+inactivation NOUN O
+by ADP O
+a DET O
+chondroitinase NOUN O
+with ADP O
+greater ADJ O
+specificity NOUN O
+than ADP O
+the DET O
+pan ADJ O
+- PUNCT O
+specific ADJ O
+ChABC PROPN B-AC
+. PUNCT O
+Here ADV O
+we PRON O
+provide VERB O
+evidence NOUN O
+that SCONJ O
+the DET O
+endoneurial ADJ O
+compartment NOUN O
+contains VERB O
+CSPGs NOUN B-AC
+with ADP O
+GAG PROPN B-AC
+chains NOUN O
+that SCONJ O
+are AUX O
+more ADV O
+specifically ADV O
+degraded VERB O
+by ADP O
+chondroitinase NOUN B-LF
+C PROPN I-LF
+( PUNCT O
+ChC PROPN B-AC
+) PUNCT O
+and CCONJ O
+that SCONJ O
+ChC PROPN B-AC
+selectively ADV O
+enhances VERB O
+the DET O
+axon NOUN O
+growth NOUN O
+- PUNCT O
+promoting VERB O
+properties NOUN O
+of ADP O
+the DET O
+endoneurial ADJ O
+basal ADJ O
+lamina NOUN O
+. PUNCT O
+
+Secondly ADV O
+, PUNCT O
+we PRON O
+knocked VERB O
+down ADP O
+the DET O
+expression NOUN O
+of ADP O
+snn NOUN O
+in ADP O
+RAW264.7 NUM O
+cells NOUN O
+using VERB O
+siRNAs NOUN B-AC
+( PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNAs NOUN I-LF
+) PUNCT O
+( PUNCT O
+S5A NOUN O
+and CCONJ O
+S5B PROPN O
+Fig PROPN O
+) PUNCT O
+and CCONJ O
+monitored VERB O
+the DET O
+formation NOUN O
+of ADP O
+acidic ADJ O
+compartments NOUN O
+with ADP O
+Lysotracker PROPN O
+. PUNCT O
+snn NOUN O
+si NOUN O
+- PUNCT O
+RNA NOUN O
+- PUNCT O
+treated VERB O
+RAW PROPN O
+264.7 NUM O
+cells NOUN O
+showed VERB O
+abnormally ADV O
+large ADJ O
+acidic ADJ O
+aggregates NOUN O
+( PUNCT O
+Fig PROPN O
+5A–5C NUM O
+) PUNCT O
+mimicking VERB O
+the DET O
+hemo NOUN B-AC
+A4 NOUN O
+null NOUN O
+phenotype NOUN O
+observed VERB O
+in ADP O
+hemocytes NOUN O
+( PUNCT O
+Fig PROPN O
+2A NUM O
+” NOUN O
+and CCONJ O
+2L NUM O
+” NOUN O
+and CCONJ O
+S1G PROPN O
+– SYM O
+S1 NOUN O
+K NOUN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+CVD NOUN B-AC
+, PUNCT O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+. PUNCT O
+
+For ADP O
+descriptive ADJ O
+statistics NOUN O
+, PUNCT O
+continuous ADJ O
+variables NOUN O
+were AUX O
+reported VERB O
+as ADP O
+medians NOUN O
+( PUNCT O
+interquartile ADJ B-LF
+ranges NOUN I-LF
+[ PUNCT O
+IQRs NOUN B-AC
+] PUNCT O
+) PUNCT O
+; PUNCT O
+categorical ADJ O
+variables NOUN O
+were AUX O
+reported VERB O
+as ADP O
+percentages NOUN O
+. PUNCT O
+
+Directly ADV B-LF
+observed VERB I-LF
+therapy NOUN I-LF
+( PUNCT O
+DOT NOUN B-AC
+) PUNCT O
+is AUX O
+the DET O
+preferred VERB O
+strategy NOUN O
+for ADP O
+active ADJ O
+TB PROPN B-AC
+treatment NOUN O
+but CCONJ O
+requires VERB O
+substantial ADJ O
+resources NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AD PROPN B-AC
+, PUNCT O
+Alzheimer PROPN B-LF
+'s PART I-LF
+disease NOUN I-LF
+; PUNCT O
+EAE PROPN B-AC
+, PUNCT O
+experimental ADJ B-LF
+autoimmune ADJ I-LF
+encephalomyelitis NOUN I-LF
+; PUNCT O
+FCI PROPN B-AC
+, PUNCT O
+focal ADJ B-LF
+cerebral ADJ I-LF
+ischaemia NOUN I-LF
+; PUNCT O
+PD PROPN O
+, PUNCT O
+Parkinson PROPN O
+'s PART O
+disease NOUN O
+; PUNCT O
+SCI PROPN B-AC
+, PUNCT O
+spinal ADJ O
+cord NOUN O
+injury NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+IDU PROPN B-AC
+, PUNCT O
+injection NOUN B-LF
+drug NOUN I-LF
+use NOUN I-LF
+; PUNCT O
+OAT PROPN B-AC
+, PUNCT O
+opioid NOUN B-LF
+agonist ADJ I-LF
+treatment NOUN I-LF
+; PUNCT O
+PRIMER PROPN B-AC
+, PUNCT O
+Preventing VERB B-LF
+Injecting VERB I-LF
+by ADP I-LF
+Modifying VERB I-LF
+Existing VERB I-LF
+Responses NOUN I-LF
+
+Experiments NOUN O
+in ADP O
+support NOUN O
+of ADP O
+this PRON O
+showed VERB O
+that SCONJ O
+the DET O
+amount NOUN O
+of ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+DSPP PROPN B-AC
+( PUNCT O
+IPV PROPN B-AC
+) PUNCT O
+secreted VERB O
+by ADP O
+human ADJ B-LF
+embryonic ADJ I-LF
+kidney NOUN I-LF
+cell NOUN I-LF
+line NOUN I-LF
+293A NOUN I-LF
+( PUNCT O
+HEK293A PROPN B-AC
+) PUNCT O
+was AUX O
+inversely ADV O
+correlated VERB O
+with ADP O
+increasing VERB O
+amounts NOUN O
+of ADP O
+coexpressed VERB O
+mutant ADJ O
+protein NOUN O
+( PUNCT O
+IPD PROPN B-AC
+, PUNCT O
+isoleucine NOUN B-LF
+- PUNCT I-LF
+serine NOUN I-LF
+- PUNCT I-LF
+valine NOUN I-LF
+[ PUNCT O
+ISV PROPN B-AC
+] PUNCT O
+, PUNCT O
+or CCONJ O
+isoleucine NOUN B-LF
+- PUNCT I-LF
+threonine NOUN I-LF
+- PUNCT I-LF
+valine NOUN I-LF
+[ PUNCT O
+ITV]-DSPP PROPN B-AC
+) PUNCT O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+To PART O
+further ADV O
+investigate VERB O
+whether SCONJ O
+AMPK PROPN B-AC
+modulates VERB O
+some DET O
+aspect NOUN O
+of ADP O
+soma NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+germline NOUN O
+communication NOUN O
+through ADP O
+the DET O
+deployment NOUN O
+of ADP O
+somatically ADV O
+derived VERB O
+small ADJ O
+endogenous ADJ O
+RNAs NOUN O
+, PUNCT O
+we PRON O
+tested VERB O
+whether SCONJ O
+the DET O
+double ADJ B-LF
+- PUNCT I-LF
+stranded ADJ I-LF
+RNA NOUN I-LF
+( PUNCT O
+dsRNA NOUN B-AC
+) PUNCT O
+importer NOUN O
+Systemic PROPN O
+RNAi PROPN B-AC
+Defective PROPN O
+( PUNCT O
+sid)-1 PROPN O
+could AUX O
+affect VERB O
+the DET O
+PD PROPN B-AC
+sterility NOUN O
+of ADP O
+AMPK PROPN B-AC
+mutants NOUN O
+by ADP O
+impairing VERB O
+the DET O
+uptake NOUN O
+of ADP O
+small ADJ O
+dsRNAs NOUN B-AC
+[ X O
+41 NUM O
+] PUNCT O
+. PUNCT O
+
+Scale NOUN O
+bars NOUN O
+represent VERB O
+25 NUM O
+μm NOUN O
+. PUNCT O
+ac NOUN B-AC
+, PUNCT O
+anterior ADJ B-LF
+commissure NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+lvCB PROPN B-AC
+, PUNCT O
+larval ADJ O
+central ADJ O
+body NOUN O
+; PUNCT O
+NS PROPN B-AC
+, PUNCT O
+neural ADJ B-LF
+stage NOUN I-LF
+; PUNCT O
+Rx NOUN B-AC
+, PUNCT O
+retinal ADJ O
+homeobox NOUN O
+. PUNCT O
+
+Montelukast PROPN O
+is AUX O
+a DET O
+leukotriene NOUN B-LF
+receptor NOUN I-LF
+antagonist NOUN I-LF
+( PUNCT O
+LTRA NOUN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+possesses VERB O
+anti ADJ O
+- ADJ O
+inflammatory ADJ O
+effects NOUN O
+, PUNCT O
+especially ADV O
+on ADP O
+eosinophilic ADJ O
+inflammation NOUN O
+[ X O
+17 NUM O
+] X O
+and CCONJ O
+is AUX O
+thought VERB O
+to PART O
+impact VERB O
+on ADP O
+airway NOUN O
+remodeling NOUN O
+. PUNCT O
+
+HCA PROPN B-AC
+, PUNCT O
+hybrid ADJ B-LF
+cellular ADJ I-LF
+automata NOUN I-LF
+; PUNCT O
+RAF PROPN B-AC
+, PUNCT O
+rapidly ADV B-LF
+accelerated VERB I-LF
+fibrosarcoma NOUN I-LF
+; PUNCT O
+RAS PROPN B-AC
+, PUNCT O
+rat NOUN B-LF
+sarcoma NOUN I-LF
+. PUNCT O
+
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+PAS PROPN B-AC
+, PUNCT O
+phagophore NOUN B-LF
+assembly NOUN I-LF
+site NOUN I-LF
+; PUNCT O
+WT PROPN O
+, PUNCT O
+wild ADJ O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+Alternative ADJ O
+fragmentation NOUN O
+sites NOUN O
+tend VERB O
+to PART O
+map VERB O
+between ADP O
+predicted VERB O
+genes NOUN O
+in ADP O
+intergenic ADJ O
+regions NOUN O
+rather ADV O
+than ADP O
+within ADP O
+intragenic ADJ O
+regions NOUN O
+[ PUNCT O
+Table PROPN O
+S1 NUM O
+; PUNCT O
+we PRON O
+use VERB O
+inter ADJ O
+- ADJ O
+CDS PROPN B-AC
+regions NOUN O
+rather ADV O
+than ADP O
+intergenic ADJ O
+regions NOUN O
+since SCONJ O
+CDS PROPN B-AC
+( PUNCT O
+coding NOUN B-LF
+sequence NOUN I-LF
+) PUNCT O
+predictions NOUN O
+are AUX O
+more ADV O
+reliable ADJ O
+than ADP O
+UTRs NOUN B-AC
+( PUNCT O
+untranslated VERB B-LF
+regions NOUN I-LF
+) PUNCT O
+] PUNCT O
+. PUNCT O
+
+Each DET O
+unit NOUN O
+was AUX O
+represented VERB O
+by ADP O
+a DET O
+one NUM B-LF
+- PUNCT I-LF
+versus ADP I-LF
+- PUNCT I-LF
+all PRON I-LF
+( PUNCT O
+OVA NOUN B-AC
+) PUNCT O
+classifier NOUN O
+that DET O
+was AUX O
+trained VERB O
+by ADP O
+logistic ADJ O
+regression NOUN O
+to PART O
+report VERB O
+the DET O
+probability NOUN O
+of ADP O
+each DET O
+stimulus NOUN O
+given VERB O
+a DET O
+single ADJ O
+- PUNCT O
+trial NOUN O
+spike NOUN O
+train NOUN O
+( PUNCT O
+0–150 NUM O
+ms NOUN O
+after ADP O
+stimulus NOUN O
+onset NOUN O
+, PUNCT O
+binned VERB O
+using VERB O
+either CCONJ O
+10 NUM O
+ms NOUN O
+bins NOUN O
+or CCONJ O
+a DET O
+single ADJ O
+fixed VERB O
+time NOUN O
+bin NOUN O
+) PUNCT O
+, PUNCT O
+selected VERB O
+randomly ADV O
+from ADP O
+recorded VERB O
+spike NOUN O
+trains NOUN O
+for ADP O
+that DET O
+unit NOUN O
+. PUNCT O
+
+On ADP O
+very ADV O
+rare ADJ O
+occasions NOUN O
+, PUNCT O
+OPV PROPN B-AC
+may AUX O
+cause VERB O
+vaccine NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+paralytic ADJ I-LF
+poliomyelitis NOUN I-LF
+( PUNCT O
+VAPP PROPN B-AC
+) PUNCT O
+, PUNCT O
+at ADP O
+a DET O
+low ADJ O
+rate NOUN O
+of ADP O
+about ADV O
+1–2 NUM O
+cases NOUN O
+of ADP O
+VAPP PROPN B-AC
+per ADP O
+million NUM O
+primary ADJ O
+immunisations NOUN O
+[ PUNCT O
+3 NUM O
+] PUNCT O
+. PUNCT O
+
+Clinical ADJ O
+disease NOUN O
+activity NOUN O
+was AUX O
+documented VERB O
+using VERB O
+established VERB O
+clinical ADJ O
+parameters NOUN O
+of ADP O
+the DET O
+Crohn PROPN B-LF
+disease NOUN I-LF
+activity NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+CDAI PROPN B-AC
+) PUNCT O
+in ADP O
+CD PROPN B-AC
+[ X O
+15 NUM O
+] X O
+and CCONJ O
+the DET O
+colitis NOUN B-LF
+activity NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+CAI PROPN B-AC
+) PUNCT O
+[ X O
+16,17 NUM O
+] X O
+for ADP O
+UC PROPN B-AC
+patients NOUN O
+. PUNCT O
+
+All DET O
+these DET O
+metabolic ADJ O
+disorders NOUN O
+can AUX O
+be AUX O
+associated VERB O
+with ADP O
+hyperglycaemia NOUN O
+and CCONJ O
+underlying VERB O
+insulin NOUN O
+resistance NOUN O
+, PUNCT O
+and CCONJ O
+thereby ADV O
+with ADP O
+the DET O
+metabolic ADJ B-LF
+syndrome NOUN I-LF
+( PUNCT O
+MetS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+23 NUM O
+, PUNCT O
+24 NUM O
+] PUNCT O
+. PUNCT O
+
+Additionally ADV O
+, PUNCT O
+transcriptomes NOUN O
+were AUX O
+compared VERB O
+to ADP O
+their PRON O
+corresponding ADJ O
+genomic ADJ O
+sequences NOUN O
+as ADP O
+a DET O
+practical ADJ O
+approach NOUN O
+for ADP O
+the DET O
+detection NOUN O
+of ADP O
+RNA NOUN B-LF
+- PUNCT I-LF
+DNA NOUN I-LF
+differences NOUN I-LF
+( PUNCT O
+RDDs NOUN B-AC
+) PUNCT O
+and CCONJ O
+identification NOUN O
+of ADP O
+the DET O
+canonical ADJ O
+A NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+I NOUN O
+and CCONJ O
+C NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+U NOUN O
+RNA NOUN O
+editing NOUN O
+sites NOUN O
+in ADP O
+diverse ADJ O
+eukaryotes NOUN O
+[ PUNCT O
+6 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+particularly ADV O
+report VERB O
+on ADP O
+the DET O
+functional ADJ O
+significance NOUN O
+of ADP O
+CB1 PROPN B-AC
+receptor NOUN O
+interactions NOUN O
+with ADP O
+the DET O
+Wiskott PROPN B-LF
+- PUNCT I-LF
+Aldrich PROPN I-LF
+syndrome PROPN I-LF
+protein NOUN I-LF
+- PUNCT I-LF
+family NOUN I-LF
+verprolin NOUN I-LF
+- PUNCT I-LF
+homologous ADJ I-LF
+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+WAVE1)/SCAR1 PROPN B-AC
+complex NOUN O
+. PUNCT O
+
+Agreement NOUN O
+between ADP O
+the DET O
+PWD PROPN B-AC
+and CCONJ O
+their PRON O
+family NOUN O
+carer NOUN O
+responses NOUN O
+was AUX O
+assessed VERB O
+using VERB O
+Kappa PROPN O
+and CCONJ O
+Prevalence PROPN B-LF
+- PUNCT I-LF
+Adjusted PROPN I-LF
+Bias PROPN I-LF
+- PUNCT I-LF
+Adjusted PROPN I-LF
+Kappa PROPN I-LF
+( PUNCT O
+PABAK PROPN B-AC
+) PUNCT O
+statistics NOUN O
+. PUNCT O
+
+The DET O
+samples NOUN O
+were AUX O
+stored VERB O
+at ADP O
+-20 NUM O
+° NOUN O
+C NOUN O
+and CCONJ O
+analyzed VERB O
+within ADP O
+a DET O
+maximum NOUN O
+of ADP O
+2 NUM O
+years NOUN O
+for ADP O
+high ADJ B-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+( PUNCT O
+HDL PROPN B-AC
+) PUNCT O
+cholesterol NOUN O
+, PUNCT O
+low ADJ O
+density NOUN O
+density NOUN O
+lipoprotein NOUN O
+( PUNCT O
+LDL PROPN B-AC
+) PUNCT O
+cholesterol NOUN O
+and CCONJ O
+total ADJ O
+cholesterol NOUN O
+( PUNCT O
+TC PROPN O
+) PUNCT O
+, PUNCT O
+triacylglycerol NOUN O
+( PUNCT O
+TG PROPN O
+) PUNCT O
+and CCONJ O
+glycated VERB O
+hemaglobin NOUN O
+( PUNCT O
+HbA1c NOUN O
+) PUNCT O
+. PUNCT O
+
+Drug NOUN O
+- PUNCT O
+drug NOUN O
+interactions NOUN O
+between ADP O
+SB-415286 PROPN B-LF
+or CCONJ O
+LiCl PROPN B-AC
+and CCONJ O
+TRAIL PROPN B-AC
+were AUX O
+evaluated VERB O
+in ADP O
+AGS PROPN O
+cells NOUN O
+by ADP O
+MTT PROPN O
+assay NOUN O
+. PUNCT O
+
+In ADP O
+conjunction NOUN O
+with ADP O
+serial ADJ B-LF
+section NOUN I-LF
+light NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT O
+ssLM NOUN B-AC
+) PUNCT O
+, PUNCT O
+we PRON O
+use VERB O
+computational ADJ B-LF
+molecular ADJ I-LF
+phenotyping NOUN I-LF
+( PUNCT O
+CMP PROPN B-AC
+, PUNCT O
+see VERB O
+Marc PROPN O
+, PUNCT O
+Murry PROPN O
+, PUNCT O
+and CCONJ O
+Basinger PROPN O
+[ PUNCT O
+54 NUM O
+] PUNCT O
+and CCONJ O
+Marc PROPN O
+and CCONJ O
+Jones PROPN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+CS NOUN B-AC
+, PUNCT O
+complex ADJ B-LF
+spike NOUN I-LF
+. PUNCT O
+
+As ADP O
+in ADP O
+the DET O
+above ADJ O
+analysis NOUN O
+of ADP O
+gene NOUN O
+expression NOUN O
+, PUNCT O
+we PRON O
+measured VERB O
+the DET O
+percentage NOUN O
+of ADP O
+CTs NOUN B-AC
+in ADP O
+three NUM O
+concentric ADJ O
+nuclear ADJ O
+shells NOUN O
+of ADP O
+equal ADJ O
+area NOUN O
+( PUNCT O
+Figure PROPN O
+4A NUM O
+) PUNCT O
+. PUNCT O
+Unexpectedly ADV O
+, PUNCT O
+all DET O
+chromosomes NOUN O
+showed VERB O
+a DET O
+significant ADJ O
+enrichment NOUN O
+in ADP O
+the DET O
+central ADJ O
+portion NOUN O
+of ADP O
+the DET O
+nucleus NOUN O
+when SCONJ O
+compared VERB O
+with ADP O
+the DET O
+middle ADJ O
+or CCONJ O
+outer ADJ O
+shells NOUN O
+, PUNCT O
+regardless ADV O
+of ADP O
+cell NOUN O
+type NOUN O
+or CCONJ O
+chromosome NOUN O
+size NOUN O
+/ SYM O
+density NOUN O
+( PUNCT O
+analysis NOUN B-LF
+of ADP I-LF
+variance NOUN I-LF
+( PUNCT O
+ANOVA NOUN B-AC
+) PUNCT O
+, PUNCT O
+p NOUN O
+< ADP O
+0.0001 NUM O
+) PUNCT O
+( PUNCT O
+Figure PROPN O
+4B NUM O
+; PUNCT O
+for ADP O
+individual ADJ O
+chromosomes NOUN O
+, PUNCT O
+see VERB O
+Figure PROPN O
+S4 NUM O
+) PUNCT O
+. PUNCT O
+
+Controlling VERB O
+the DET O
+FDR NOUN B-AC
+at ADP O
+nominal ADJ O
+level NOUN O
+of ADP O
+20 NUM O
+% PUNCT O
+, PUNCT O
+we PRON O
+selected VERB O
+6 NUM O
+associated VERB O
+signals NOUN O
+: PUNCT O
+rs4879801 NOUN O
+( PUNCT O
+DNAI1 NOUN O
+, PUNCT O
+Dynein PROPN O
+intermediate NOUN O
+chain PROPN O
+1 NUM O
+, PUNCT O
+axonemal NOUN O
+) PUNCT O
+, PUNCT O
+rs1203638 NOUN O
+( PUNCT O
+PRDM2 NOUN B-AC
+, PUNCT O
+PR PROPN B-LF
+domain NOUN I-LF
+zinc NOUN I-LF
+finger NOUN I-LF
+protein NOUN I-LF
+2 NUM I-LF
+) PUNCT O
+, PUNCT O
+rs1626645 NOUN O
+and CCONJ O
+rs894324 NOUN O
+( PUNCT O
+ASB7 NOUN B-AC
+region NOUN O
+for ADP O
+the DET O
+last ADJ O
+2 NUM O
+, PUNCT O
+Ankyrin PROPN B-LF
+repeat NOUN I-LF
+and CCONJ I-LF
+SOCS PROPN I-LF
+box NOUN I-LF
+protein NOUN I-LF
+7 NUM I-LF
+) PUNCT O
+, PUNCT O
+rs4879795 NOUN O
+( PUNCT O
+DNAI1 NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+rs10508884 NOUN O
+( PUNCT O
+CXCL12 PROPN O
+) PUNCT O
+( PUNCT O
+Table NOUN O
+4 NUM O
+, PUNCT O
+Fig PROPN O
+5A NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+value NOUN O
+of ADP O
+the DET O
+genomic ADJ O
+control NOUN O
+was AUX O
+close ADJ O
+to ADP O
+one NUM O
+. PUNCT O
+
+Incremental ADJ B-LF
+cost NOUN I-LF
+- PUNCT I-LF
+effectiveness NOUN I-LF
+ratios NOUN I-LF
+( PUNCT O
+ICERs NOUN B-AC
+) PUNCT O
+were AUX O
+estimated VERB O
+to ADP O
+compare VERB O
+the DET O
+2 NUM O
+intervention NOUN O
+arms NOUN O
+to ADP O
+the DET O
+SOC PROPN B-AC
+arm NOUN O
+. PUNCT O
+
+During ADP O
+our PRON O
+ongoing ADJ O
+quest NOUN O
+for ADP O
+physiological ADJ O
+functions NOUN O
+of ADP O
+Smurfs PROPN B-AC
+, PUNCT O
+we PRON O
+found VERB O
+abnormal ADJ O
+accumulation NOUN O
+of ADP O
+lipid NOUN O
+droplets NOUN O
+in ADP O
+the DET O
+livers NOUN O
+of ADP O
+9–12 NUM O
+- PUNCT O
+month NOUN O
+- PUNCT O
+old ADJ O
+Smurf1 PROPN O
+knockout NOUN B-LF
+( PUNCT O
+KO PROPN B-AC
+) PUNCT O
+mice NOUN O
+and CCONJ O
+other ADJ O
+signs NOUN O
+that PRON O
+phenocopy VERB O
+NAFLD PROPN B-AC
+in ADP O
+human ADJ O
+patients NOUN O
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+the DET O
+cells NOUN O
+were AUX O
+cultured VERB O
+for ADP O
+11 NUM O
+days NOUN O
+in ADP O
+various ADJ O
+hepatocyte NOUN O
+culture NOUN O
+medium NOUN O
+with ADP O
+20 NUM O
+ng NOUN O
+/ SYM O
+ml NOUN O
+oncostatin NOUN B-LF
+M PROPN I-LF
+( PUNCT O
+OsM PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+At ADP O
+baseline NOUN O
+, PUNCT O
+1.5 NUM O
+% NOUN O
+had VERB O
+an DET O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+eGFR NOUN B-AC
+) PUNCT O
+< ADP O
+70 NUM O
+mL NOUN O
+/ SYM O
+min/1.73m2 NUM O
+. PUNCT O
+
+A NOUN B-AC
+/ SYM B-AC
+P NOUN B-AC
+, PUNCT O
+anterior ADJ B-LF
+– PUNCT I-LF
+posterior NOUN I-LF
+; PUNCT O
+BE PROPN B-AC
+, PUNCT O
+Boundary NOUN B-LF
+enhancer NOUN I-LF
+; PUNCT O
+D NOUN B-AC
+/ SYM B-AC
+V NOUN B-AC
+, PUNCT O
+dorso NOUN B-LF
+– PUNCT I-LF
+ventral NOUN I-LF
+; PUNCT O
+Dpp PROPN B-AC
+, PUNCT O
+Decapentaplegic NOUN B-LF
+; PUNCT O
+Ds PROPN B-AC
+, PUNCT O
+Dachsous NOUN B-LF
+; PUNCT O
+FF PROPN B-AC
+, PUNCT O
+feed NOUN B-LF
+- PUNCT I-LF
+forward NOUN I-LF
+; PUNCT O
+Fj PROPN B-AC
+, PUNCT O
+Four NUM B-LF
+- PUNCT I-LF
+Jointed PROPN I-LF
+; PUNCT O
+Ft PROPN B-AC
+, PUNCT O
+Fat PROPN B-LF
+; PUNCT O
+PCP PROPN O
+, PUNCT O
+planar NOUN O
+cell NOUN O
+polarity NOUN O
+; PUNCT O
+QE PROPN B-AC
+, PUNCT O
+Quadrant NOUN B-LF
+enhancer NOUN I-LF
+; PUNCT O
+Sd PROPN O
+, PUNCT O
+Scalloped VERB O
+; PUNCT O
+Vg PROPN B-AC
+, PUNCT O
+Vestigial NOUN B-LF
+; PUNCT O
+Wg PROPN B-AC
+, PUNCT O
+Wingless PROPN B-LF
+; PUNCT O
+Wts PROPN B-AC
+, PUNCT O
+Warts NOUN B-LF
+; PUNCT O
+Yki PROPN B-AC
+, PUNCT O
+Yorkie PROPN B-LF
+. PUNCT O
+
+All DET O
+participants NOUN O
+with ADP O
+AF PROPN B-AC
+qualified VERB O
+for ADP O
+anticoagulation NOUN O
+and CCONJ O
+were AUX O
+more ADV O
+likely ADJ O
+to PART O
+be AUX O
+male ADJ O
+( PUNCT O
+57.7 NUM O
+% PUNCT O
+) PUNCT O
+; PUNCT O
+be AUX O
+older ADJ O
+; PUNCT O
+have VERB O
+an DET O
+increased ADJ O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI NOUN B-AC
+) PUNCT O
+; PUNCT O
+and CCONJ O
+have VERB O
+a DET O
+CHA2DS2 PROPN B-AC
+- PUNCT B-AC
+VASc PROPN B-AC
+( PUNCT O
+Congestive ADJ B-LF
+heart NOUN I-LF
+failure NOUN I-LF
+, PUNCT I-LF
+Hypertension NOUN I-LF
+, PUNCT I-LF
+Age NOUN I-LF
+≥ ADP I-LF
+75 NUM I-LF
+years NOUN I-LF
+, PUNCT I-LF
+Diabetes NOUN I-LF
+, PUNCT I-LF
+previous ADJ I-LF
+Stroke NOUN I-LF
+, PUNCT I-LF
+Vascular ADJ I-LF
+disease NOUN I-LF
+, PUNCT I-LF
+Age NOUN I-LF
+65–74 NUM I-LF
+years NOUN I-LF
+, PUNCT I-LF
+Sex NOUN I-LF
+category NOUN I-LF
+) PUNCT O
+score NOUN O
+≥ ADP O
+3 NUM O
+. PUNCT O
+
+We PRON O
+identified VERB O
+a DET O
+brown ADJ O
+adipose ADJ O
+tissue NOUN O
+– PUNCT O
+enriched VERB O
+lncRNA NOUN B-AC
+, PUNCT O
+lncBATE10 PROPN O
+, PUNCT O
+that PRON O
+was AUX O
+governed VERB O
+by ADP O
+the DET O
+cAMP NOUN O
+- PUNCT O
+cAMP NOUN B-LF
+response NOUN I-LF
+element NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+( PUNCT O
+Creb PROPN B-AC
+) PUNCT O
+axis NOUN O
+and CCONJ O
+required VERB O
+for ADP O
+a DET O
+full ADJ O
+brown ADJ O
+fat NOUN O
+differentiation NOUN O
+and CCONJ O
+white ADJ O
+fat NOUN O
+browning NOUN O
+program NOUN O
+. PUNCT O
+
+Other ADJ O
+secondary ADJ O
+outcomes NOUN O
+were AUX O
+changes NOUN O
+in ADP O
+postprandial ADJ O
+endothelial ADJ O
+function NOUN O
+( PUNCT O
+FDR PROPN B-AC
+, PUNCT O
+peak ADJ O
+FBF PROPN B-AC
+, PUNCT O
+and CCONJ O
+duration NOUN O
+of ADP O
+RH NOUN B-AC
+) PUNCT O
+, PUNCT O
+nutritional ADJ O
+intake NOUN O
+, PUNCT O
+bodyweight NOUN O
+, PUNCT O
+body NOUN O
+fat NOUN O
+, PUNCT O
+plasma NOUN O
+levels NOUN O
+of ADP O
+glucose NOUN O
+and CCONJ O
+insulin NOUN O
+in ADP O
+the DET O
+fasting ADJ O
+and CCONJ O
+postprandial ADJ O
+states NOUN O
+, PUNCT O
+HbA1c NOUN B-AC
+, PUNCT O
+glycoalbumin NOUN O
+, PUNCT O
+triglyceride NOUN O
+, PUNCT O
+total NOUN O
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+( PUNCT O
+HDL)- PROPN B-AC
+and CCONJ O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+( PUNCT O
+LDL)-cholesterol NOUN B-AC
+, PUNCT O
+adiponectin NOUN O
+, PUNCT O
+ADMA PROPN B-AC
+, PUNCT O
+tissue NOUN B-LF
+plasminogen NOUN I-LF
+activator NOUN I-LF
+inhibitor-1 NOUN I-LF
+( PUNCT O
+tPAI-1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+high ADJ O
+- PUNCT O
+sensitivity NOUN O
+C NOUN O
+- PUNCT O
+reactive ADJ O
+protein NOUN O
+( PUNCT O
+hs NOUN O
+- PUNCT O
+CRP PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+urine NOUN O
+levels NOUN O
+of ADP O
+8 NUM O
+- PUNCT O
+isoprostane NOUN O
+. PUNCT O
+
+BRT PROPN B-AC
+, PUNCT O
+boosted VERB B-LF
+regression NOUN I-LF
+tree NOUN I-LF
+; PUNCT O
+Chla PROPN O
+, PUNCT O
+chlorophyll NOUN O
+- PUNCT O
+a DET O
+concentration NOUN O
+; PUNCT O
+Dist PROPN O
+coast NOUN O
+, PUNCT O
+distance NOUN O
+to ADP O
+nearest ADJ O
+coast NOUN O
+; PUNCT O
+Dist PROPN O
+CoralTri PROPN O
+, PUNCT O
+distance NOUN O
+to ADP O
+the DET O
+Coral PROPN O
+Triangle PROPN O
+; PUNCT O
+Dist PROPN O
+market NOUN O
+, PUNCT O
+distance NOUN O
+to ADP O
+nearest ADJ O
+market NOUN O
+; PUNCT O
+Dist PROPN O
+seamount NOUN O
+, PUNCT O
+distance NOUN O
+to ADP O
+nearest ADJ O
+seamount NOUN O
+with ADP O
+a DET O
+summit NOUN O
+depth NOUN O
+of ADP O
+< ADP O
+1,500 NUM O
+m NOUN O
+; PUNCT O
+SST PROPN B-AC
+, PUNCT O
+sea NOUN B-LF
+surface NOUN I-LF
+temperature NOUN I-LF
+. PUNCT O
+
+RTP PROPN B-AC
+, PUNCT O
+Arabidopsis PROPN O
+thaliana NOUN O
+ribulose NOUN O
+bisphosphate NOUN O
+carboxylase NOUN O
+small ADJ O
+subunit NOUN O
+transit NOUN O
+peptide NOUN O
+; PUNCT O
+SaSSy PROPN B-AC
+, PUNCT O
+Santalum PROPN O
+album NOUN O
+santalene NOUN B-LF
+synthase NOUN I-LF
+; PUNCT O
+FPS PROPN B-AC
+, PUNCT O
+A. NOUN O
+thaliana NOUN O
+farnesyl NOUN B-LF
+diphosphate NOUN I-LF
+synthase NOUN I-LF
+; PUNCT O
+HMGR PROPN B-AC
+, PUNCT O
+A. NOUN O
+thaliana NOUN O
+3 NUM B-LF
+- PUNCT I-LF
+hydroxy-3 NOUN I-LF
+- PUNCT I-LF
+methylglutaryl NOUN I-LF
+- PUNCT I-LF
+CoA NOUN I-LF
+reductase NOUN I-LF
+; PUNCT O
+tHMGR PROPN B-AC
+, PUNCT O
+A. NOUN O
+thaliana NOUN O
+truncated VERB O
+HMGR PROPN B-AC
+. PUNCT O
+SaCYP76F39v1 PROPN O
+, PUNCT O
+Santalum PROPN O
+album NOUN O
+santalene NOUN O
+/ SYM O
+bergamotene NOUN O
+oxidase(CYP76F39v1 NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+presented VERB O
+adjusted VERB O
+values NOUN O
+at ADP O
+3 NUM O
+, PUNCT O
+6 NUM O
+, PUNCT O
+9 NUM O
+and CCONJ O
+12 NUM O
+months NOUN O
+and CCONJ O
+their PRON O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+are AUX O
+similar ADJ O
+to ADP O
+the DET O
+unadjusted ADJ O
+values NOUN O
+( PUNCT O
+not PART O
+presented VERB O
+) PUNCT O
+. PUNCT O
+
+Underlying VERB O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+exorh PROPN B-AC
+, PUNCT O
+exorhodopsin NOUN B-LF
+; PUNCT O
+hpf NOUN B-AC
+, PUNCT O
+hours NOUN B-LF
+post NOUN I-LF
+fertilization NOUN I-LF
+; PUNCT O
+post NOUN O
+, PUNCT O
+posterior NOUN O
+; PUNCT O
+PhR NOUN B-AC
+, PUNCT O
+photoreceptor NOUN B-LF
+; PUNCT O
+PT NOUN B-AC
+, PUNCT O
+parietopsin NOUN B-LF
+. PUNCT O
+
+Urine NOUN O
+, PUNCT O
+blood NOUN O
+, PUNCT O
+and CCONJ O
+renal ADJ O
+tissues NOUN O
+were AUX O
+collected VERB O
+at ADP O
+the DET O
+end NOUN O
+of ADP O
+the DET O
+experiment NOUN O
+for ADP O
+assessment NOUN O
+of ADP O
+kidney NOUN O
+function NOUN O
+tests NOUN O
+( PUNCT O
+serum NOUN O
+creatinine NOUN O
+and CCONJ O
+urea NOUN O
+) PUNCT O
+, PUNCT O
+urinary ADJ O
+( PUNCT O
+8 NUM B-LF
+- NOUN I-LF
+hydroxydeoxyguanosine NOUN I-LF
+( PUNCT O
+8 NUM B-AC
+- NOUN B-AC
+OHdG NOUN B-AC
+) PUNCT O
+, PUNCT O
+calcium NOUN O
+and CCONJ O
+oxalate NOUN O
+) PUNCT O
+, PUNCT O
+inflammatory ADJ O
+and CCONJ O
+oxdative ADJ O
+stress NOUN O
+biomarkers NOUN O
+( PUNCT O
+transforming VERB B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+beta NOUN I-LF
+( PUNCT O
+TGF PROPN B-AC
+- NOUN B-AC
+β PROPN B-AC
+) PUNCT O
+, PUNCT O
+osteopontin NOUN B-LF
+( PUNCT O
+OPN PROPN B-AC
+) PUNCT O
+and CCONJ O
+ratio NOUN O
+of ADP O
+reduced VERB O
+glutathione NOUN O
+to ADP O
+oxidized VERB O
+glutathione NOUN O
+( PUNCT O
+GSH PROPN B-AC
+/ SYM B-AC
+GSSG PROPN B-AC
+) PUNCT O
+) PUNCT O
+in ADP O
+renal ADJ O
+tissue NOUN O
+. PUNCT O
+
+1H NOUN O
+, PUNCT O
+high ADJ O
+; PUNCT O
+L NOUN O
+, PUNCT O
+low ADJ O
+; PUNCT O
+NA PROPN O
+, PUNCT O
+not PART O
+applicable ADJ O
+; PUNCT O
+RCT PROPN B-AC
+, PUNCT O
+randomized ADJ B-LF
+controlled ADJ I-LF
+trial NOUN I-LF
+; PUNCT O
+ROB PROPN B-AC
+, PUNCT O
+risk NOUN B-LF
+of ADP I-LF
+bias NOUN I-LF
+; PUNCT O
+U NOUN O
+, PUNCT O
+unclear ADJ O
+. PUNCT O
+
+The DET O
+per ADP O
+- PUNCT O
+capita NOUN O
+– PUNCT O
+demand NOUN O
+( PUNCT O
+PCD NOUN O
+) PUNCT O
+expressed VERB O
+in ADP O
+liters NOUN B-LF
+per ADP I-LF
+capita NOUN I-LF
+per ADP I-LF
+day NOUN I-LF
+( PUNCT O
+lpcd NOUN B-AC
+) PUNCT O
+is AUX O
+the DET O
+coefficient NOUN O
+used VERB O
+for ADP O
+modeling VERB O
+water NOUN O
+demands NOUN O
+by ADP O
+population NOUN O
+dependent ADJ O
+sectors NOUN O
+. PUNCT O
+
+The DET O
+renin NOUN B-LF
+- PUNCT I-LF
+angiotensin NOUN I-LF
+aldosterone NOUN I-LF
+hormone NOUN I-LF
+system NOUN I-LF
+’s PART O
+( PUNCT O
+RAAS PROPN B-AC
+) PUNCT O
+main ADJ O
+function NOUN O
+is AUX O
+to PART O
+maintain VERB O
+the DET O
+homeostasis NOUN O
+of ADP O
+arterial ADJ O
+pressure NOUN O
+and CCONJ O
+of ADP O
+extracellular ADJ O
+fluids NOUN O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+ARV PROPN O
+= VERB O
+antiretroviral ADJ O
+; PUNCT O
+HTC PROPN B-AC
+= VERB O
+HIV PROPN B-LF
+testing NOUN I-LF
+and CCONJ I-LF
+counseling NOUN I-LF
+; PUNCT O
+PMTCT PROPN B-AC
+= VERB O
+prevention NOUN B-LF
+of ADP I-LF
+mother NOUN I-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+child NOUN I-LF
+transmission NOUN I-LF
+; PUNCT O
+VMMC PROPN B-AC
+= VERB O
+voluntary ADJ B-LF
+medical ADJ I-LF
+male ADJ I-LF
+circumcision NOUN I-LF
+. PUNCT O
+
+G PROPN B-LF
+protein NOUN I-LF
+– PUNCT I-LF
+coupled VERB I-LF
+receptors NOUN I-LF
+( PUNCT O
+GPCRs PROPN B-AC
+) PUNCT O
+exist VERB O
+in ADP O
+multiple ADJ O
+dynamic ADJ O
+states NOUN O
+( PUNCT O
+e.g. X O
+, PUNCT O
+ligand NOUN O
+- PUNCT O
+bound VERB O
+, PUNCT O
+inactive ADJ O
+, PUNCT O
+G PROPN B-AC
+protein NOUN B-AC
+– PUNCT O
+coupled VERB O
+) PUNCT O
+that PRON O
+influence VERB O
+G PROPN B-AC
+protein NOUN B-AC
+activation NOUN O
+and CCONJ O
+ultimately ADV O
+response NOUN O
+generation NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AMR PROPN B-AC
+, PUNCT O
+antimicrobial ADJ B-LF
+resistance NOUN I-LF
+. PUNCT O
+
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+per ADP O
+the DET O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+guidelines NOUN O
+( PUNCT O
+S4 NUM O
+Appendix NOUN O
+) PUNCT O
+. PUNCT O
+
+ACR PROPN B-AC
+, PUNCT O
+albumin NOUN B-LF
+: PUNCT I-LF
+creatinine NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+BP PROPN B-AC
+, PUNCT O
+blood NOUN B-LF
+pressure NOUN I-LF
+; PUNCT O
+CHD PROPN B-AC
+, PUNCT O
+coronary ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+CKD PROPN B-AC
+, PUNCT O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+eGFR NOUN B-AC
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+ESRD NOUN B-AC
+, PUNCT O
+end NOUN B-LF
+- PUNCT I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+HbA1c NOUN B-AC
+, PUNCT O
+hemoglobin NOUN B-LF
+A1c NOUN I-LF
+; PUNCT O
+HDL PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+JADE PROPN B-AC
+, PUNCT O
+Joint PROPN B-LF
+Asia PROPN I-LF
+Diabetes PROPN I-LF
+Evaluation PROPN I-LF
+; PUNCT O
+JADE PROPN B-AC
+- PUNCT B-AC
+P PROPN B-AC
+, PUNCT O
+JADE PROPN B-LF
+- PUNCT I-LF
+Personalized VERB I-LF
+; PUNCT O
+LDL PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+MI PROPN O
+, PUNCT O
+myocardial ADJ O
+infarction NOUN O
+; PUNCT O
+PVD PROPN B-AC
+, PUNCT O
+peripheral ADJ B-LF
+vascular ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+RASi PROPN B-AC
+, PUNCT O
+renin NOUN B-LF
+- PUNCT I-LF
+angiotensin NOUN I-LF
+system NOUN I-LF
+inhibitors NOUN I-LF
+. PUNCT O
+
+Coronavirus NOUN B-LF
+disease NOUN I-LF
+2019 NUM I-LF
+( PUNCT O
+COVID-19 NOUN B-AC
+) PUNCT O
+, PUNCT O
+caused VERB O
+by ADP O
+severe ADJ B-LF
+acute ADJ I-LF
+respiratory ADJ I-LF
+syndrome NOUN I-LF
+coronavirus-2 NOUN I-LF
+( PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+has AUX O
+caused VERB O
+a DET O
+pandemic NOUN O
+with ADP O
+millions NOUN O
+of ADP O
+cases NOUN O
+and CCONJ O
+deaths NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+ChIP PROPN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+sequencing NOUN I-LF
+; PUNCT O
+FOXO1 PROPN O
+, PUNCT O
+Forkhead PROPN O
+Box PROPN O
+O1 PROPN O
+; PUNCT O
+Fr PROPN B-AC
+. PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+proliferating VERB B-LF
+B NOUN I-LF
+cell NOUN I-LF
+progenitor NOUN I-LF
+; PUNCT O
+Fr PROPN B-AC
+. PUNCT B-AC
+D PROPN B-AC
+, PUNCT O
+differentiating VERB B-LF
+B NOUN I-LF
+cell NOUN I-LF
+progenitor NOUN I-LF
+; PUNCT O
+OR PROPN O
+, PUNCT O
+odds NOUN O
+ratio NOUN O
+; PUNCT O
+scRNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+single ADJ B-LF
+cell NOUN I-LF
+RNA NOUN I-LF
+sequencing NOUN I-LF
+; PUNCT O
+4 NUM B-AC
+- PUNCT B-AC
+OHT NOUN B-AC
+, PUNCT O
+4 NUM B-LF
+- PUNCT I-LF
+hydroxy NOUN I-LF
+- PUNCT I-LF
+tamoxifen NOUN I-LF
+. PUNCT O
+
+AURAH2 PROPN B-AC
+, PUNCT O
+The DET B-LF
+Attitudes PROPN I-LF
+to ADP I-LF
+and CCONJ I-LF
+Understanding PROPN I-LF
+of ADP I-LF
+Risk PROPN I-LF
+of ADP I-LF
+Acquisition PROPN I-LF
+of ADP I-LF
+HIV PROPN I-LF
+2 NUM I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+GBMSM PROPN B-AC
+, PUNCT O
+gay ADJ B-LF
+, PUNCT I-LF
+bisexual ADJ I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+other ADJ I-LF
+men NOUN I-LF
+who PRON I-LF
+have VERB I-LF
+sex NOUN I-LF
+with ADP I-LF
+men NOUN I-LF
+; PUNCT O
+IR PROPN B-AC
+, PUNCT O
+incidence NOUN B-LF
+rate NOUN I-LF
+; PUNCT O
+PY PROPN B-AC
+, PUNCT O
+person NOUN B-LF
+- PUNCT I-LF
+years NOUN I-LF
+. PUNCT O
+
+Briefly ADV O
+, PUNCT O
+DR1+DO PROPN B-AC
+- PUNCT O
+WT PROPN B-AC
+and CCONJ O
+DR1+DO PROPN B-AC
+- PUNCT O
+KO PROPN B-AC
+mice NOUN O
+received VERB O
+a DET O
+primary ADJ O
+subcutaneous ADJ O
+tail NOUN O
+injection NOUN O
+of ADP O
+bovine ADJ B-LF
+type NOUN I-LF
+II NUM I-LF
+collagen NOUN I-LF
+( PUNCT O
+bCII NOUN B-AC
+) PUNCT O
+protein NOUN O
+followed VERB O
+by ADP O
+a DET O
+second ADJ O
+subcutaneous ADJ O
+tail NOUN O
+immunization NOUN O
+21 NUM O
+days NOUN O
+later ADV O
+( PUNCT O
+Materials NOUN O
+and CCONJ O
+methods NOUN O
+) PUNCT O
+. PUNCT O
+
+FITC PROPN O
+, PUNCT O
+fluorescein NOUN O
+isothiocyanate NOUN O
+; PUNCT O
+G6PDH PROPN O
+, PUNCT O
+glucose-6 NUM O
+- PUNCT O
+phosphate NOUN O
+dehydrogenase NOUN O
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+The DET O
+STAT3 PROPN B-AC
+- PUNCT B-AC
+LPX PROPN B-AC
+had VERB O
+an DET O
+average ADJ O
+diameter NOUN O
+of ADP O
+3.50±0.29 NUM O
+μm NOUN O
+with ADP O
+an DET O
+average ADJ O
+concentration NOUN O
+of ADP O
+2×109 NUM O
+microbubbles NOUN B-LF
+/ SYM O
+mL NOUN O
+and CCONJ O
+a DET O
+loading NOUN O
+capacity NOUN O
+of ADP O
+50 NUM O
+μg NOUN O
+of ADP O
+STAT3 PROPN B-AC
+decoy NOUN O
+per ADP O
+1×109 NUM O
+microbubbles NOUN B-LF
+( PUNCT O
+5 NUM O
+- PUNCT O
+fold ADJ O
+higher ADJ O
+than ADP O
+STAT3 PROPN B-AC
+- PUNCT B-AC
+MB NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Using VERB O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+high ADJ I-LF
+- PUNCT I-LF
+resolution NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT O
+LC NOUN B-AC
+- PUNCT B-AC
+HR NOUN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+/ SYM B-AC
+MS PROPN B-AC
+) PUNCT O
+analysis NOUN O
+, PUNCT O
+we PRON O
+discovered VERB O
+1,360 NUM O
+differentially ADV O
+expressed VERB O
+proteins NOUN O
+in ADP O
+CLL PROPN B-AC
+patients NOUN O
+compared VERB O
+to PART O
+healthy ADJ O
+donors NOUN O
+, PUNCT O
+several ADJ O
+of ADP O
+which PRON O
+had AUX O
+been AUX O
+previously ADV O
+reported VERB O
+to PART O
+be AUX O
+associated VERB O
+with ADP O
+cancer NOUN O
+, PUNCT O
+yet CCONJ O
+four NUM O
+of ADP O
+which PRON O
+were AUX O
+identified VERB O
+as ADP O
+being AUX O
+associated VERB O
+with ADP O
+any DET O
+cancer NOUN O
+, PUNCT O
+including VERB O
+CLL PROPN B-AC
+, PUNCT O
+for ADP O
+the DET O
+first ADJ O
+time NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+IRE1 PROPN B-AC
+, PUNCT O
+inositol NOUN B-LF
+- PUNCT I-LF
+requiring VERB I-LF
+enzyme NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+eIF2 PROPN B-AC
+, PUNCT O
+eukaryotic ADJ B-LF
+initiation NOUN I-LF
+factor NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+CHOP PROPN B-AC
+, PUNCT O
+C NOUN B-LF
+/ SYM I-LF
+EBP NOUN I-LF
+- PUNCT I-LF
+homologous ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+HR PROPN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+HS PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+salt NOUN I-LF
+; PUNCT O
+LPS PROPN B-AC
+, PUNCT O
+lipopolysaccharide NOUN B-LF
+; PUNCT O
+MΦ PROPN B-AC
+, PUNCT O
+monocyte NOUN B-LF
+/ SYM I-LF
+macrophage NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+cell NOUN I-LF
+; PUNCT O
+[ X O
+Na+]i X O
+, PUNCT O
+intracellular ADJ O
+Na+ NOUN O
+in ADP O
+situ NOUN O
+; PUNCT O
+NS PROPN B-AC
+, PUNCT O
+normal ADJ B-LF
+salt NOUN I-LF
+. PUNCT O
+
+The DET O
+hypocholesterolaemic ADJ O
+effect NOUN O
+in ADP O
+the DET O
+liver NOUN O
+was AUX O
+associated VERB O
+with ADP O
+decreased VERB O
+relative ADJ O
+expression NOUN O
+of ADP O
+3 NUM O
+- PUNCT O
+hydroxy-3 NOUN O
+- PUNCT O
+methyl NOUN O
+- PUNCT O
+glutaryl NOUN O
+- PUNCT O
+coenzyme NOUN O
+A NOUN O
+reductase NOUN O
+( PUNCT O
+HMGCR PROPN O
+, PUNCT O
+a DET O
+key ADJ O
+enzyme NOUN O
+involved VERB O
+in ADP O
+cholesterol NOUN O
+synthesis NOUN O
+) PUNCT O
+and CCONJ O
+stearoyl NOUN B-LF
+- PUNCT I-LF
+CoA PROPN I-LF
+desaturase NOUN I-LF
+1(SCD-1 PROPN B-AC
+, PUNCT O
+a DET O
+key ADJ O
+lipogenic ADJ O
+enzyme NOUN O
+) PUNCT O
+( PUNCT O
+Figs NOUN O
+2 NUM O
+and CCONJ O
+3 NUM O
+) PUNCT O
+. PUNCT O
+
+Data NOUN O
+are AUX O
+reported VERB O
+as ADP O
+median ADJ O
+and CCONJ O
+interquartile ADJ B-LF
+range NOUN I-LF
+( PUNCT O
+IQR PROPN B-AC
+) PUNCT O
+or CCONJ O
+mean NOUN O
+± SYM O
+standard ADJ O
+deviation NOUN O
+for ADP O
+continuous ADJ O
+variables NOUN O
+and CCONJ O
+as ADP O
+proportions NOUN O
+for ADP O
+categorical ADJ O
+variables NOUN O
+. PUNCT O
+
+This DET O
+study NOUN O
+examines VERB O
+the DET O
+relationship NOUN O
+between ADP O
+IgE PROPN B-AC
+responses NOUN O
+to ADP O
+multiple ADJ O
+allergen NOUN O
+components NOUN O
+in ADP O
+component NOUN B-LF
+- PUNCT I-LF
+resolved VERB I-LF
+diagnostics NOUN I-LF
+( PUNCT O
+CRD PROPN B-AC
+) PUNCT O
+and CCONJ O
+their PRON O
+associations NOUN O
+with ADP O
+asthma NOUN O
+. PUNCT O
+
+All DET O
+media NOUN O
+were AUX O
+autoclaved VERB O
+at ADP O
+121 NUM O
+° NOUN O
+C NOUN O
+for ADP O
+21 NUM O
+min NOUN O
+, PUNCT O
+and CCONJ O
+once SCONJ O
+the DET O
+temperature NOUN O
+of ADP O
+the DET O
+media NOUN O
+was AUX O
+lower ADJ O
+than ADP O
+50 NUM O
+° NOUN O
+C NOUN O
+, PUNCT O
+glutamine(Gln NOUN B-LF
+) PUNCT O
+, PUNCT O
+acid NOUN B-LF
+hydrolysed VERB I-LF
+casein(CH NOUN I-LF
+) PUNCT O
+, PUNCT O
+inositol NOUN O
+, PUNCT O
+kanamycin(Kan NOUN B-LF
+) PUNCT O
+, PUNCT O
+gentamicin(Gen NOUN B-LF
+) PUNCT O
+, PUNCT O
+cefotaxime(Cef NOUN B-LF
+) PUNCT O
+, PUNCT O
+hygromycin NOUN B-LF
+B(Hyg PROPN I-LF
+) PUNCT O
+, PUNCT O
+Acetosyringone NOUN B-LF
+( PUNCT O
+As PROPN B-AC
+) PUNCT O
+, PUNCT O
+2 NUM O
+4 NUM O
+- PUNCT O
+D NOUN O
+and CCONJ O
+KT NOUN B-AC
+were AUX O
+added VERB O
+after ADP O
+filtering VERB O
+. PUNCT O
+
+The DET O
+objectives NOUN O
+of ADP O
+this DET O
+study NOUN O
+were AUX O
+to PART O
+( PUNCT O
+1 X O
+) PUNCT O
+simulate VERB O
+the DET O
+transmission NOUN O
+dynamics NOUN O
+of ADP O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+using VERB O
+publicly ADV O
+available ADJ O
+surveillance NOUN O
+data NOUN O
+and CCONJ O
+( PUNCT O
+2 X O
+) PUNCT O
+infer VERB O
+estimates NOUN O
+of ADP O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+mortality NOUN O
+adjusted VERB O
+for ADP O
+biases NOUN O
+and CCONJ O
+examine VERB O
+the DET O
+CFR PROPN B-AC
+, PUNCT O
+the DET O
+symptomatic ADJ B-LF
+case NOUN I-LF
+– PUNCT I-LF
+fatality NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+sCFR PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+infection NOUN B-LF
+– PUNCT I-LF
+fatality NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+IFR PROPN B-AC
+) PUNCT O
+in ADP O
+different ADJ O
+geographic ADJ O
+locations NOUN O
+. PUNCT O
+
+Statistical ADJ O
+significance NOUN O
+was AUX O
+performed VERB O
+by ADP O
+chi NOUN O
+- PUNCT O
+square ADJ O
+test NOUN O
+. PUNCT O
+( PUNCT O
+F NOUN O
+) PUNCT O
+A NOUN O
+proposed VERB O
+model NOUN O
+for ADP O
+P. PROPN O
+gingivalis PROPN O
+- PUNCT O
+induced VERB O
+aggressive ADJ O
+progression NOUN O
+of ADP O
+ESCC PROPN B-AC
+. PUNCT O
+ESCC PROPN B-AC
+, PUNCT O
+esophageal ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+; PUNCT O
+GARP PROPN B-AC
+, PUNCT O
+glycoprotein NOUN B-LF
+A NOUN I-LF
+repetitions NOUN I-LF
+predominant ADJ I-LF
+; PUNCT O
+IHC PROPN B-AC
+, PUNCT O
+immunohistochemistry NOUN B-LF
+; PUNCT O
+LAP PROPN O
+, PUNCT O
+latency NOUN O
+- PUNCT O
+associated VERB O
+protein NOUN O
+; PUNCT O
+Lats PROPN B-AC
+, PUNCT O
+large ADJ B-LF
+tumor NOUN I-LF
+suppressor NOUN I-LF
+homolog NOUN I-LF
+; PUNCT O
+Merlin PROPN B-AC
+, PUNCT O
+moesin NOUN B-LF
+- PUNCT I-LF
+ezrin NOUN I-LF
+- PUNCT I-LF
+radixin NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+pS PROPN O
+, PUNCT O
+phosphorylated VERB O
+serine NOUN O
+/ SYM O
+threonine NOUN O
+; PUNCT O
+pSmad PROPN B-AC
+, PUNCT O
+phosphorylated VERB B-LF
+Smad PROPN I-LF
+; PUNCT O
+SARA PROPN O
+, PUNCT O
+Smad PROPN O
+anchor NOUN O
+receptor NOUN O
+activation NOUN O
+; PUNCT O
+Smad PROPN O
+, PUNCT O
+Drosophila PROPN O
+mothers NOUN O
+against ADP O
+decapentaplegic ADJ O
+homolog NOUN O
+; PUNCT O
+TAZ PROPN B-AC
+, PUNCT O
+Transcriptional ADJ B-LF
+coactivator NOUN I-LF
+with ADP I-LF
+PDZ NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+motif NOUN I-LF
+; PUNCT O
+TEAD1 PROPN B-AC
+, PUNCT O
+TEA PROPN B-LF
+domain NOUN I-LF
+transcription NOUN I-LF
+factor1 NOUN I-LF
+; PUNCT O
+TGFβ PROPN B-AC
+, PUNCT O
+transforming VERB B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+- PUNCT I-LF
+β NOUN I-LF
+; PUNCT O
+TNM PROPN B-AC
+, PUNCT O
+tumor NOUN B-LF
+- PUNCT I-LF
+node NOUN I-LF
+metastasis NOUN I-LF
+; PUNCT O
+YAP PROPN B-AC
+, PUNCT O
+Yes PROPN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+. PUNCT O
+
+We PRON O
+defined VERB O
+A PROPN O
+Body PROPN B-LF
+Shape PROPN I-LF
+Index PROPN I-LF
+( PUNCT O
+ABSI PROPN B-AC
+) PUNCT O
+according VERB O
+to ADP O
+the DET O
+definition NOUN O
+by ADP O
+Krakauer PROPN O
+N.Y. PROPN O
+et NOUN O
+al NOUN O
+. NOUN O
+[ X O
+8 NUM O
+] X O
+based VERB O
+on ADP O
+WC PROPN B-AC
+adjusted VERB O
+for ADP O
+height NOUN O
+and CCONJ O
+weight NOUN O
+: PUNCT O
+ABSI PROPN B-AC
+= SYM O
+WCBMI2/3Height1/2 NUM O
+
+Residual ADJ B-LF
+dipolar ADJ I-LF
+couplings NOUN I-LF
+( PUNCT O
+RDCs PROPN B-AC
+) PUNCT O
+[ X O
+33 NUM O
+] PUNCT O
+report VERB O
+on ADP O
+time NOUN O
+and CCONJ O
+ensemble NOUN O
+- PUNCT O
+averaged VERB O
+conformations NOUN O
+[ X O
+34 NUM O
+] PUNCT O
+and CCONJ O
+can AUX O
+be AUX O
+used VERB O
+to PART O
+understand VERB O
+both CCONJ O
+the DET O
+structure NOUN O
+and CCONJ O
+dynamics NOUN O
+of ADP O
+disordered ADJ O
+proteins NOUN O
+[ X O
+35 NUM O
+] PUNCT O
+. PUNCT O
+
+Three NUM O
+- PUNCT O
+year NOUN O
+cumulative ADJ O
+mortality NOUN O
+risk NOUN O
+was AUX O
+3.2 NUM O
+% NOUN O
+( PUNCT O
+174/5,422 NUM O
+) PUNCT O
+in ADP O
+the DET O
+intervention NOUN O
+arm NOUN O
+and CCONJ O
+4.1 NUM O
+% NOUN O
+( PUNCT O
+225/5,426 NUM O
+) PUNCT O
+in ADP O
+the DET O
+control NOUN O
+arm NOUN O
+, PUNCT O
+corresponding VERB O
+to PART O
+a DET O
+21 NUM O
+% NOUN O
+reduction NOUN O
+in ADP O
+3 NUM O
+- PUNCT O
+year NOUN O
+mortality NOUN O
+in ADP O
+communities NOUN O
+that PRON O
+received VERB O
+the DET O
+SEARCH PROPN B-AC
+intervention NOUN O
+( PUNCT O
+aRR NOUN B-AC
+0.79 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+0.64 NUM O
+to PART O
+0.97 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.028 NUM O
+) PUNCT O
+( PUNCT O
+Figs NOUN O
+2 NUM O
+and CCONJ O
+3 NUM O
+, PUNCT O
+Table NOUN O
+D NOUN O
+in ADP O
+S1 NOUN O
+Tables NOUN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+used VERB O
+interrupted VERB B-LF
+time NOUN I-LF
+series NOUN I-LF
+( PUNCT O
+ITS PROPN B-AC
+) PUNCT O
+analysis NOUN O
+to PART O
+examine VERB O
+trends NOUN O
+in ADP O
+annual ADJ O
+LARC ADJ B-AC
+and CCONJ O
+non ADJ B-LF
+- ADJ I-LF
+LARC ADJ I-LF
+hormonal ADJ I-LF
+contraception NOUN I-LF
+( PUNCT O
+NLHC PROPN B-AC
+) PUNCT O
+uptake NOUN O
+and CCONJ O
+abortion NOUN O
+rates NOUN O
+, PUNCT O
+stratified VERB O
+by ADP O
+age NOUN O
+and CCONJ O
+deprivation NOUN O
+groups NOUN O
+, PUNCT O
+before ADP O
+and CCONJ O
+after SCONJ O
+the DET O
+P4P PROPN B-AC
+was AUX O
+introduced VERB O
+in ADP O
+2009/2010 NUM O
+. PUNCT O
+
+The DET O
+World PROPN O
+Health PROPN O
+Organization PROPN O
+( PUNCT O
+WHO PROPN O
+) PUNCT O
+provides VERB O
+information NOUN O
+( PUNCT O
+in ADP O
+several ADJ O
+languages NOUN O
+) PUNCT O
+on ADP O
+all DET O
+aspects NOUN O
+of ADP O
+tuberculosis NOUN O
+, PUNCT O
+including VERB O
+general ADJ O
+information NOUN O
+on ADP O
+tuberculosis NOUN O
+diagnostics NOUN O
+and CCONJ O
+specific ADJ O
+information NOUN O
+on ADP O
+the DET O
+roll NOUN O
+out ADP O
+of ADP O
+the DET O
+Xpert PROPN B-LF
+MTB PROPN I-LF
+/ SYM I-LF
+RIF PROPN I-LF
+test NOUN O
+; PUNCT O
+further ADJ O
+information NOUN O
+about ADP O
+WHO PROPN O
+'s PART O
+endorsement NOUN O
+of ADP O
+Xpert PROPN B-LF
+MTB PROPN I-LF
+/ SYM I-LF
+RIF PROPN I-LF
+is AUX O
+included VERB O
+in ADP O
+a DET O
+Strategic PROPN O
+and CCONJ O
+Technical PROPN O
+Advisory PROPN O
+Group PROPN O
+for ADP O
+Tuberculosis PROPN O
+report NOUN O
+; PUNCT O
+the DET O
+Global PROPN O
+Tuberculosis PROPN O
+Report PROPN O
+2013 NUM O
+provides VERB O
+information NOUN O
+about ADP O
+tuberculosis NOUN O
+around ADP O
+the DET O
+world NOUN O
+, PUNCT O
+including VERB O
+in ADP O
+India PROPN O
+
+They PRON O
+develop VERB O
+from ADP O
+a DET O
+cylinder NOUN O
+- PUNCT O
+shaped ADJ O
+invagination NOUN O
+of ADP O
+the DET O
+dental ADJ O
+lamina NOUN O
+, PUNCT O
+the DET O
+so ADV O
+- PUNCT O
+called VERB O
+dental ADJ O
+epithelium NOUN O
+[ X O
+24–26 NUM O
+] PUNCT O
+, PUNCT O
+where SCONJ O
+tooth NOUN O
+- PUNCT O
+specific ADJ O
+signaling NOUN O
+centers NOUN O
+, PUNCT O
+called VERB O
+primary ADJ B-LF
+enamel NOUN I-LF
+knots NOUN I-LF
+( PUNCT O
+PEKs PROPN B-AC
+) PUNCT O
+, PUNCT O
+are AUX O
+patterned VERB O
+. PUNCT O
+
+RAW264.7 NUM O
+cells NOUN O
+( PUNCT O
+kindly ADV O
+gifted VERB O
+by ADP O
+Ian PROPN O
+Clarke PROPN O
+, PUNCT O
+University PROPN O
+of ADP O
+Southampton PROPN O
+) PUNCT O
+and CCONJ O
+BHK-21 NOUN B-AC
+cells NOUN O
+( PUNCT O
+obtained VERB O
+from ADP O
+the DET O
+ATCC PROPN O
+; PUNCT O
+Manassas PROPN O
+, PUNCT O
+VA PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+were AUX O
+maintained VERB O
+in ADP O
+high ADJ O
+- PUNCT O
+glucose ADJ O
+Dulbecco PROPN B-LF
+’s PART I-LF
+Modified PROPN I-LF
+Eagle PROPN I-LF
+’s PART I-LF
+Medium PROPN I-LF
+( PUNCT O
+DMEM PROPN B-AC
+) PUNCT O
+supplemented VERB O
+with ADP O
+10 NUM O
+% NOUN O
+( PUNCT O
+v NOUN O
+/ SYM O
+v NOUN O
+) PUNCT O
+foetal ADJ O
+bovine ADJ O
+serum NOUN O
+, PUNCT O
+20 NUM O
+mM NOUN O
+HEPES PROPN O
+buffer NOUN O
+, PUNCT O
+and CCONJ O
+50 NUM O
+U NOUN O
+/ SYM O
+ml NOUN O
+penicillin NOUN O
+and CCONJ O
+streptomycin NOUN O
+. PUNCT O
+
+The DET O
+nurses NOUN B-LF
+’ PART I-LF
+willingness NOUN I-LF
+questionnaire NOUN I-LF
+( PUNCT O
+NWQ PROPN B-AC
+) PUNCT O
+was AUX O
+used VERB O
+to PART O
+measure VERB O
+the DET O
+willingness NOUN O
+of ADP O
+nurses NOUN O
+to PART O
+perform VERB O
+activities NOUN O
+on ADP O
+HIV PROPN B-AC
+- PUNCT O
+positive ADJ O
+patients NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+DV NOUN O
+= PUNCT O
+dependent ADJ O
+variable NOUN O
+; PUNCT O
+IV NOUN O
+= PUNCT O
+independent ADJ O
+variable NOUN O
+; PUNCT O
+β NOUN O
+= PUNCT O
+standardised ADJ O
+regression NOUN O
+coefficient NOUN O
+; PUNCT O
+B NOUN O
+= PUNCT O
+unstandardized ADJ O
+regression NOUN O
+coefficient NOUN O
+; PUNCT O
+MVPA NOUN B-AC
+= PUNCT O
+moderate ADJ B-LF
+to ADP I-LF
+vigorous ADJ I-LF
+physical ADJ I-LF
+activity NOUN I-LF
+; PUNCT O
+6MWD NOUN B-AC
+= PUNCT O
+six NUM B-LF
+- PUNCT I-LF
+minute NOUN I-LF
+walk NOUN I-LF
+distance NOUN I-LF
+, PUNCT O
+normalised VERB O
+to ADP O
+height NOUN O
+; PUNCT O
+RCH PROPN O
+= PUNCT O
+The DET O
+Royal PROPN O
+Children PROPN O
+’s PART O
+Hospital PROPN O
+, PUNCT O
+Melbourne PROPN O
+; PUNCT O
+CHW PROPN O
+= PUNCT O
+Children PROPN O
+’s PART O
+Hospital PROPN O
+Westmead PROPN O
+, PUNCT O
+Sydney PROPN O
+
+Protein NOUN B-LF
+energy NOUN I-LF
+wasting NOUN I-LF
+( PUNCT O
+PEW NOUN B-AC
+) PUNCT O
+and CCONJ O
+low ADJ O
+physical ADJ O
+activity NOUN O
+could AUX O
+impair VERB O
+muscle NOUN O
+quality NOUN O
+and CCONJ O
+contribute VERB O
+to ADP O
+muscle NOUN O
+weakness NOUN O
+beyond ADP O
+muscle NOUN O
+wasting NOUN O
+in ADP O
+these DET O
+patients NOUN O
+. PUNCT O
+
+To PART O
+address VERB O
+the DET O
+gap NOUN O
+regarding VERB O
+estimates NOUN O
+on ADP O
+the DET O
+burden NOUN O
+of ADP O
+stroke NOUN O
+in ADP O
+Brazilian ADJ O
+young ADJ O
+population NOUN O
+, PUNCT O
+this DET O
+study NOUN O
+aimed VERB O
+to PART O
+analyze VERB O
+stroke NOUN O
+- PUNCT O
+related VERB O
+mortality NOUN O
+and CCONJ O
+incidence NOUN O
+of ADP O
+hospital NOUN O
+admissions NOUN O
+in ADP O
+Brazilians NOUN O
+aged VERB O
+15 NUM O
+to PART O
+49 NUM O
+years NOUN O
+between ADP O
+2008 NUM O
+and CCONJ O
+2012 NUM O
+, PUNCT O
+by ADP O
+using VERB O
+data NOUN O
+provided VERB O
+by ADP O
+the DET O
+Department PROPN B-LF
+of ADP I-LF
+Informatics PROPN I-LF
+of ADP I-LF
+the DET I-LF
+National PROPN I-LF
+Health PROPN I-LF
+System PROPN I-LF
+( PUNCT O
+DATASUS PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+include VERB O
+96.1 NUM O
+% NOUN O
+of ADP O
+deaths NOUN O
+reports NOUN O
+in ADP O
+the DET O
+country NOUN O
+[ X O
+11 NUM O
+] PUNCT O
+and CCONJ O
+is AUX O
+maintained VERB O
+by ADP O
+the DET O
+Brazilian ADJ O
+Ministry PROPN O
+of ADP O
+Health PROPN O
+. PUNCT O
+
+Then ADV O
+, PUNCT O
+the DET O
+DNA PROPN O
+fragment NOUN O
+containing VERB O
+the DET O
+mouse NOUN O
+Ucp1 PROPN O
+gene NOUN O
+( PUNCT O
+-3.87 NUM O
+K NUM O
+to PART O
++248 NUM O
+( PUNCT O
+upstream NOUN O
+of ADP O
+ATG PROPN O
+) PUNCT O
+) PUNCT O
+, PUNCT O
+an DET O
+artificial ADJ O
+intron NOUN O
+, PUNCT O
+the DET O
+iRFP720 PROPN O
+gene NOUN O
+, PUNCT O
+the DET O
+bovine ADJ B-LF
+growth NOUN I-LF
+hormone NOUN I-LF
+polyadenylation NOUN I-LF
+signal NOUN I-LF
+( PUNCT O
+BGHpA PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+mouse NOUN O
+Ucp1 PROPN O
+gene NOUN O
+( PUNCT O
++249 NUM O
+to PART O
++4.56 NUM O
+K NUM O
+) PUNCT O
+were AUX O
+inserted VERB O
+sequentially ADV O
+into ADP O
+pBluescript PROPN O
+II NUM O
+KS PROPN O
+( PUNCT O
+- PUNCT O
+) PUNCT O
+vector NOUN O
+. PUNCT O
+
+Repetitive ADJ B-LF
+Transcranial PROPN I-LF
+Magnetic PROPN I-LF
+Stimulation PROPN I-LF
+[ PUNCT O
+rTMS PROPN B-AC
+] PUNCT O
+is AUX O
+increasingly ADV O
+being AUX O
+used VERB O
+to PART O
+treat VERB O
+Major PROPN B-LF
+Depressive PROPN I-LF
+Disorder PROPN I-LF
+[ PUNCT O
+MDD PROPN B-AC
+] PUNCT O
+. PUNCT O
+Given VERB O
+that PRON O
+not PART O
+all DET O
+patients NOUN O
+respond VERB O
+to PART O
+rTMS PROPN B-AC
+, PUNCT O
+it PRON O
+would AUX O
+be AUX O
+clinically ADV O
+useful ADJ O
+to PART O
+have VERB O
+reliable ADJ O
+biomarkers NOUN O
+that PRON O
+predict VERB O
+treatment NOUN O
+response NOUN O
+. PUNCT O
+
+The DET O
+author NOUN O
+did AUX O
+not PART O
+find VERB O
+safety NOUN O
+problems NOUN O
+reported VERB O
+by ADP O
+France PROPN O
+, PUNCT O
+Germany PROPN O
+, PUNCT O
+or CCONJ O
+the DET O
+United PROPN B-LF
+Kingdom PROPN I-LF
+( PUNCT O
+UK PROPN B-AC
+) PUNCT O
+related VERB O
+to ADP O
+the DET O
+five NUM O
+devices NOUN O
+rejected VERB O
+by ADP O
+the DET O
+FDA PROPN B-AC
+, PUNCT O
+and CCONJ O
+concluded VERB O
+( PUNCT O
+based VERB O
+on ADP O
+this DET O
+extremely ADV O
+limited ADJ O
+sample NOUN O
+) PUNCT O
+that SCONJ O
+the DET O
+EU PROPN B-AC
+regulatory ADJ O
+system NOUN O
+has VERB O
+a DET O
+lower ADJ O
+burden NOUN O
+of ADP O
+proof NOUN O
+for ADP O
+approval NOUN O
+and CCONJ O
+faster ADJ O
+approval NOUN O
+time NOUN O
+, PUNCT O
+without ADP O
+risk NOUN O
+to ADP O
+patient NOUN O
+safety NOUN O
+. PUNCT O
+
+BW NOUN B-AC
+= PUNCT O
+body NOUN B-LF
+weight NOUN I-LF
+. PUNCT O
+
+GalT PROPN B-AC
+- PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+GalT PROPN B-AC
+fused VERB O
+with ADP O
+GFP PROPN B-AC
+; PUNCT O
+Hrs PROPN B-AC
+, PUNCT O
+hepatocyte NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+- PUNCT I-LF
+regulated VERB I-LF
+tyrosine NOUN I-LF
+kinase NOUN I-LF
+substrate NOUN I-LF
+; PUNCT O
+Rab5 PROPN B-AC
+, PUNCT O
+Rabaptin PROPN O
+5 NUM O
+; PUNCT O
+RNAi NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+. PUNCT O
+
+Similarly ADV O
+, PUNCT O
+using VERB O
+Microsoft PROPN O
+Office PROPN O
+Excel PROPN O
+the DET O
+breed NOUN O
+- PUNCT O
+specific ADJ O
+SNP NOUN B-LF
+database NOUN I-LF
+of ADP O
+bovine ADJ O
+pituitary ADJ O
+gland NOUN O
+were AUX O
+further ADV O
+trimmed VERB O
+to ADP O
+a DET O
+highly ADV O
+reliable ADJ O
+breed NOUN O
+- PUNCT O
+specific ADJ O
+SNP NOUN B-AC
+- PUNCT B-AC
+db NOUN B-AC
+according VERB O
+to ADP O
+SNP NOUN B-AC
+type NOUN O
+, PUNCT O
+de X O
+novo X O
+SNP NOUN B-AC
+and CCONJ O
+annotated VERB O
+SNPs NOUN B-AC
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+PAD PROPN O
+. PUNCT O
+peripheral ADJ O
+artery NOUN O
+disease NOUN O
+; PUNCT O
+CVD NOUN O
+. PUNCT O
+cerebrovascular ADJ O
+disease NOUN O
+; PUNCT O
+TIA PROPN O
+. PUNCT O
+transient ADJ O
+ischemic ADJ O
+attack NOUN O
+; PUNCT O
+CAD NOUN B-AC
+. PUNCT O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+LVEF PROPN B-AC
+. PUNCT O
+left ADJ B-LF
+ventricle ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+; PUNCT O
+IABP PROPN B-AC
+. PUNCT O
+intra ADJ B-LF
+- ADJ I-LF
+aortic ADJ I-LF
+balloon NOUN I-LF
+pump NOUN I-LF
+; PUNCT O
+LAAO PROPN O
+. PUNCT O
+left ADJ O
+atrial ADJ O
+appendage NOUN O
+occlusion NOUN O
+. PUNCT O
+
+M NOUN O
+, PUNCT O
+Minus X O
+; PUNCT O
+map NOUN B-AC
+, PUNCT O
+mating NOUN B-LF
+type NOUN I-LF
+auxiliary ADJ I-LF
+plus NOUN I-LF
+; PUNCT O
+mfm NOUN B-AC
+, PUNCT O
+mating NOUN B-LF
+factor NOUN I-LF
+minus NOUN I-LF
+; PUNCT O
+P NOUN O
+, PUNCT O
+Plus NOUN O
+; PUNCT O
+So PROPN B-AC
+, PUNCT O
+Schizosaccharomyces NOUN B-LF
+octosporus NOUN I-LF
+; PUNCT O
+Sp PROPN B-AC
+, PUNCT O
+Schizosaccharomyces NOUN B-LF
+pombe NOUN I-LF
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+an DET O
+aliquot NOUN O
+of ADP O
+supernatant NOUN B-LF
+was AUX O
+incubated VERB O
+with ADP O
+VSV PROPN B-AC
+- PUNCT O
+NJ PROPN O
+neutralizing VERB O
+mAb NOUN B-AC
+H6B9D5 PROPN O
+prior ADV O
+to PART O
+testing VERB O
+the DET O
+remaining VERB O
+infectivity NOUN O
+[ PUNCT O
+see VERB O
+PFU PROPN B-AC
+/ SYM O
+ml PROPN O
+SN PROPN B-AC
+( SYM O
++ SYM O
+VSV PROPN B-AC
+- PUNCT O
+NJ PROPN O
+nAb PROPN B-AC
+) PUNCT O
+] PUNCT O
+to PART O
+discriminate VERB O
+rLCMV NOUN B-AC
+/ SYM B-AC
+INDG PROPN B-AC
+from ADP O
+rLCMV NOUN B-AC
+/ SYM B-AC
+NJG PROPN B-AC
+infectivity NOUN O
+. PUNCT O
+
+Few ADJ O
+published VERB O
+postoperative ADJ O
+risk NOUN O
+prediction NOUN O
+models NOUN O
+using VERB O
+electronic ADJ B-LF
+health NOUN I-LF
+record NOUN I-LF
+( PUNCT O
+EHR PROPN B-AC
+) PUNCT O
+data NOUN O
+exist VERB O
+. PUNCT O
+
+This PRON O
+results VERB O
+in ADP O
+a DET O
+Matthews PROPN B-LF
+correlation NOUN I-LF
+coefficient NOUN I-LF
+( PUNCT O
+MCC PROPN B-AC
+) PUNCT O
+of ADP O
+0.983 NUM O
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+demonstrate VERB O
+an DET O
+unexpected ADJ O
+role NOUN O
+of ADP O
+LSM12 PROPN B-AC
+and CCONJ O
+its PRON O
+downstream ADJ O
+effector NOUN O
+, PUNCT O
+exchange NOUN B-LF
+protein NOUN I-LF
+directly ADV I-LF
+activated VERB I-LF
+by ADP I-LF
+cyclic ADJ I-LF
+AMP PROPN I-LF
+1 NUM I-LF
+( PUNCT O
+EPAC1 PROPN B-AC
+; PUNCT O
+also ADV O
+known VERB O
+as ADP O
+RAPGEF3 PROPN O
+) PUNCT O
+in ADP O
+establishing VERB O
+a DET O
+robust ADJ O
+nucleocytoplasmic NOUN O
+gradient NOUN O
+of ADP O
+RAN PROPN O
+- PUNCT O
+GTP PROPN O
+. PUNCT O
+Consequently ADV O
+, PUNCT O
+LSM12 PROPN B-AC
+- PUNCT O
+EPAC1 PROPN B-AC
+constitutes VERB O
+an DET O
+ATXN2 NOUN B-AC
+- PUNCT O
+independent ADJ O
+neuroprotective ADJ O
+pathway NOUN O
+that PRON O
+sustains VERB O
+NCT PROPN B-AC
+and CCONJ O
+suppresses VERB O
+the DET O
+cellular ADJ O
+pathogenesis NOUN O
+of ADP O
+poly(GR)-induced ADJ O
+neurodegeneration NOUN O
+. PUNCT O
+
+FSEC PROPN B-AC
+, PUNCT O
+fluorescence NOUN B-LF
+detection NOUN I-LF
+size NOUN I-LF
+exclusion NOUN I-LF
+chromatography NOUN I-LF
+. PUNCT O
+
+CRC PROPN B-AC
+, PUNCT O
+colorectal ADJ B-LF
+cancer NOUN I-LF
+; PUNCT O
+DM NOUN B-AC
+, PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+; PUNCT O
+FDR NOUN B-AC
+, PUNCT O
+first ADJ B-LF
+- PUNCT I-LF
+degree NOUN I-LF
+relative NOUN I-LF
+. PUNCT O
+
+DO VERB B-AC
+, PUNCT O
+H2 PROPN O
+- PUNCT O
+O PROPN O
+; PUNCT O
+DR1 PROPN B-AC
+, PUNCT O
+HLA PROPN B-LF
+- PUNCT I-LF
+DR1 PROPN I-LF
+; PUNCT O
+KO NOUN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+The DET O
+proteins NOUN O
+were AUX O
+then ADV O
+assayed VERB O
+for ADP O
+dithiothreitol NOUN B-LF
+( PUNCT O
+DTT)- NOUN B-AC
+and CCONJ O
+Trx NOUN B-AC
+- PUNCT O
+dependent ADJ O
+Met NOUN B-AC
+- PUNCT B-AC
+SO NOUN B-AC
+reduction NOUN O
+. PUNCT O
+
+A DET O
+helper ADJ O
+plasmid NOUN O
+FHR PROPN O
+, PUNCT O
+that PRON O
+is AUX O
+nonmobile ADJ O
+and CCONJ O
+thus ADV O
+behaves VERB O
+like ADP O
+a DET O
+chromosomal ADJ O
+allele NOUN O
+, PUNCT O
+governs VERB O
+the DET O
+host NOUN O
+cell NOUN O
+donor NOUN O
+ability NOUN O
+for ADP O
+a DET O
+mobile ADJ O
+plasmid NOUN O
+C PROPN O
+, PUNCT O
+which PRON O
+confers VERB O
+chloramphenicol NOUN B-LF
+( PUNCT O
+Cm PROPN B-AC
+) PUNCT O
+resistance NOUN O
+. PUNCT O
+
+Mean ADJ B-LF
+differences NOUN I-LF
+( PUNCT O
+MDs NOUN B-AC
+) PUNCT O
+with ADP O
+95 NUM O
+% NOUN O
+CIs NOUN B-AC
+were AUX O
+calculated VERB O
+for ADP O
+continuous ADJ O
+outcomes NOUN O
+. PUNCT O
+
+FDC PROPN B-AC
+, PUNCT O
+single ADJ B-LF
+- PUNCT I-LF
+pill NOUN I-LF
+fixed ADJ I-LF
+- PUNCT I-LF
+dose NOUN I-LF
+combination NOUN I-LF
+. PUNCT O
+
+( PUNCT O
+A X O
+) PUNCT O
+Standard ADJ O
+histology NOUN O
+immunostaining NOUN O
+for ADP O
+high ADJ O
+molecular ADJ O
+weight NOUN O
+cytokeratins NOUN O
+and CCONJ O
+p63 NOUN O
+( PUNCT O
+basal ADJ O
+cell NOUN O
+markers NOUN O
+in ADP O
+brown ADJ O
+) PUNCT O
+and CCONJ O
+α NOUN O
+- PUNCT O
+methylacyl NOUN O
+- PUNCT O
+CoA NOUN O
+racemase NOUN O
+( PUNCT O
+cancer NOUN O
+cell NOUN O
+marker NOUN O
+in ADP O
+red ADJ O
+) PUNCT O
+, PUNCT O
+followed VERB O
+by ADP O
+hematoxylin NOUN B-LF
+and CCONJ I-LF
+eosin NOUN I-LF
+( PUNCT O
+H&E PROPN B-AC
+) PUNCT O
+counterstaining VERB O
+to PART O
+identify VERB O
+high ADJ B-LF
+- PUNCT I-LF
+grade NOUN I-LF
+prostatic ADJ I-LF
+intraepithelial ADJ I-LF
+neoplasia NOUN I-LF
+( PUNCT O
+HGPIN PROPN B-AC
+) PUNCT O
+and CCONJ O
+intraductal ADJ B-LF
+carcinoma NOUN I-LF
+of ADP I-LF
+the DET I-LF
+prostate NOUN I-LF
+( PUNCT O
+IDC PROPN B-AC
+- PUNCT B-AC
+P PROPN B-AC
+) PUNCT O
+along ADP O
+with ADP O
+adjacent ADJ O
+cancer NOUN O
+. PUNCT O
+
+Aβ NOUN B-AC
+, PUNCT O
+amyloid NOUN B-LF
+- PUNCT I-LF
+beta NOUN I-LF
+; PUNCT O
+B NOUN O
+, PUNCT O
+unstandardized ADJ O
+regression NOUN O
+coefficient NOUN O
+; PUNCT O
+OR NOUN O
+, PUNCT O
+odds NOUN O
+ratio NOUN O
+; PUNCT O
+SD NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+drink NOUN I-LF
+; PUNCT O
+SUVR PROPN B-AC
+, PUNCT O
+standardized ADJ B-LF
+uptake NOUN I-LF
+value NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+VL PROPN B-AC
+, PUNCT O
+viral ADJ B-LF
+load NOUN I-LF
+. PUNCT O
+
+Dub NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+dual ADJ B-LF
+- PUNCT I-LF
+barcoded NOUN I-LF
+shotgun NOUN I-LF
+expression NOUN I-LF
+library NOUN I-LF
+sequencing NOUN I-LF
+. PUNCT O
+
+AMI PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+myocardial ADJ I-LF
+infarction NOUN I-LF
+; PUNCT O
+COPD PROPN B-AC
+, PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+eGFR PROPN B-AC
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+LVEF PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+. PUNCT O
+
+We PRON O
+selected VERB O
+the DET O
+fourth ADJ O
+sniff NOUN O
+- PUNCT O
+response NOUN O
+during ADP O
+ethyl NOUN O
+butyrate NOUN O
+presentation NOUN O
+as ADP O
+the DET O
+basis NOUN O
+for ADP O
+our PRON O
+movie NOUN O
+( PUNCT O
+between ADP O
+vertical ADJ O
+lines NOUN O
+, PUNCT O
+magnified VERB O
+in SCONJ O
+D NOUN O
+) PUNCT O
+. PUNCT O
+Traces NOUN O
+were AUX O
+deconvolved VERB O
+( PUNCT O
+deconv NOUN O
+) PUNCT O
+with ADP O
+a DET O
+610 NUM O
+ms NOUN O
+off ADP O
+- PUNCT O
+time NOUN O
+constant NOUN O
+to PART O
+yield VERB O
+the DET O
+red ADJ O
+traces NOUN O
+. PUNCT O
+fps NOUN B-AC
+: PUNCT O
+frames NOUN B-LF
+per ADP I-LF
+second NOUN I-LF
+. PUNCT O
+( PUNCT O
+D NOUN O
+) PUNCT O
+The DET O
+temporal ADJ O
+dynamics NOUN O
+of ADP O
+the DET O
+S+ NOUN O
+movie NOUN O
+between ADP O
+the DET O
+anterior ADJ O
+and CCONJ O
+posterior ADJ O
+ROI NOUN O
+differ VERB O
+( PUNCT O
+red ADJ O
+traces NOUN O
+) PUNCT O
+, PUNCT O
+in SCONJ O
+that SCONJ O
+the DET O
+anterior ADJ O
+ROI NOUN O
+turns VERB O
+on ADP O
+and CCONJ O
+off ADP O
+more ADV O
+slowly ADV O
+. PUNCT O
+
+Hypoxia NOUN B-LF
+/ SYM I-LF
+normoxia NOUN I-LF
+( PUNCT O
+H NOUN B-AC
+/ SYM B-AC
+N NOUN B-AC
+) PUNCT O
+caused VERB O
+50 NUM O
+% NOUN O
+drop NOUN O
+in ADP O
+cell NOUN O
+viability NOUN O
+of ADP O
+AGS PROPN O
+, PUNCT O
+RIE1 PROPN O
+and CCONJ O
+Caco-2 PROPN O
+cells NOUN O
+but CCONJ O
+PSTI NOUN B-AC
+( PUNCT O
+10 NUM O
+μg NOUN O
+/ SYM O
+ml NOUN O
+) PUNCT O
+given VERB O
+prior- ADJ O
+or CCONJ O
+during ADP O
+- PUNCT O
+hypoxic ADJ O
+period NOUN O
+improved VERB O
+survival NOUN O
+by ADP O
+50 NUM O
+% NOUN O
+( PUNCT O
+p<0.01 NUM O
+) PUNCT O
+. PUNCT O
+
+To PART O
+further ADV O
+investigate VERB O
+the DET O
+role NOUN O
+of ADP O
+SNX3 PROPN O
+in ADP O
+early ADJ O
+- PUNCT O
+to ADP O
+- PUNCT O
+late ADJ O
+endosome NOUN O
+transport NOUN O
+, PUNCT O
+we PRON O
+made VERB O
+use NOUN O
+of ADP O
+vesicular ADJ B-LF
+stomatitis NOUN I-LF
+virus NOUN I-LF
+( PUNCT O
+VSV PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+infects VERB O
+cells NOUN O
+from ADP O
+the DET O
+endocytic ADJ O
+pathway NOUN O
+. PUNCT O
+
+RT NOUN B-AC
+= PUNCT O
+Retention NOUN B-LF
+Time NOUN I-LF
+; PUNCT O
+m NOUN B-AC
+/ SYM B-AC
+z NOUN B-AC
+= PUNCT O
+mass NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+charge NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+ppm NOUN B-AC
+= PUNCT O
+part NOUN B-LF
+per ADP I-LF
+million NUM I-LF
+; PUNCT O
+AUC NOUN B-AC
+= PUNCT O
+Area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+Curve NOUN I-LF
+; PUNCT O
+ROC NOUN B-AC
+= PUNCT O
+receiver NOUN B-LF
+operating NOUN I-LF
+characteristics NOUN I-LF
+; PUNCT O
+Sp NOUN B-AC
+= PUNCT O
+specificity NOUN B-LF
+; PUNCT O
+Se NOUN B-AC
+= PUNCT O
+sensitivity NOUN B-LF
+; PUNCT O
+the DET O
+optimal ADJ O
+threshold NOUN O
+used VERB O
+for ADP O
+specificity NOUN B-LF
+and CCONJ O
+sensitivity NOUN B-LF
+is AUX O
+the DET O
+point NOUN O
+closest ADJ O
+to ADP O
+the DET O
+top ADJ O
+- PUNCT O
+left ADJ O
+part NOUN O
+of ADP O
+the DET O
+plot NOUN O
+with ADP O
+perfect ADJ O
+sensitivity NOUN B-LF
+or CCONJ O
+specificity NOUN B-LF
+. PUNCT O
+
+REE X B-AC
+: PUNCT O
+resting VERB B-LF
+energy NOUN I-LF
+expenditure NOUN I-LF
+
+EPL PROPN B-AC
+, PUNCT O
+external ADJ B-LF
+plexiform ADJ I-LF
+layer NOUN I-LF
+; PUNCT O
+LFP PROPN B-AC
+, PUNCT O
+local ADJ B-LF
+field NOUN I-LF
+potential NOUN I-LF
+; PUNCT O
+MCL PROPN B-AC
+, PUNCT O
+mitral ADJ B-LF
+cell NOUN I-LF
+layer NOUN I-LF
+; PUNCT O
+MTC PROPN B-AC
+, PUNCT O
+mitral ADJ B-LF
+and CCONJ I-LF
+tufted ADJ I-LF
+cell NOUN I-LF
+; PUNCT O
+MUA PROPN B-AC
+, PUNCT O
+multiunit NOUN B-LF
+activity NOUN I-LF
+; PUNCT O
+OB NOUN B-AC
+, PUNCT O
+olfactory NOUN B-LF
+bulb NOUN I-LF
+; PUNCT O
+P NOUN O
+, PUNCT O
+postnatal ADJ O
+day NOUN O
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+respiration NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+rhythm NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+BC1 PROPN B-AC
+first ADJ B-LF
+breast NOUN I-LF
+cancer NOUN I-LF
+, PUNCT O
+BC2 PROPN B-AC
+second ADJ B-LF
+breast NOUN I-LF
+cancer NOUN I-LF
+, PUNCT O
+CBC PROPN B-AC
+Contralateral ADJ B-LF
+breast NOUN I-LF
+cancer NOUN I-LF
+, PUNCT O
+EGFR PROPN B-AC
+Epidermial ADJ O
+growth NOUN O
+factor NOUN O
+receptor NOUN O
+, PUNCT O
+ER PROPN O
+Estrogen PROPN O
+receptor NOUN O
+, PUNCT O
+HIF PROPN B-AC
+Hypoxia NOUN B-LF
+- PUNCT I-LF
+inducible ADJ I-LF
+factor NOUN I-LF
+. PUNCT O
+
+Participants NOUN O
+were AUX O
+randomized VERB O
+into ADP O
+three NUM O
+arms NOUN O
+: PUNCT O
+melarsoprol NOUN B-LF
+- PUNCT I-LF
+nifurtimox NOUN I-LF
+( PUNCT O
+M+N NOUN B-AC
+) PUNCT O
+, PUNCT O
+melarsoprol NOUN B-LF
+- PUNCT I-LF
+eflornithine NOUN I-LF
+( PUNCT O
+M+E NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+nifurtimox NOUN B-LF
+- PUNCT I-LF
+eflornithine NOUN I-LF
+( PUNCT O
+N+E NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+MSP-119 PROPN B-AC
+is AUX O
+made VERB O
+up ADP O
+of ADP O
+two NUM O
+epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+modules NOUN I-LF
+( PUNCT O
+EGF-1 PROPN B-AC
+and CCONJ O
+EGF-2 NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+These DET O
+responses NOUN O
+involve VERB O
+activation NOUN O
+of ADP O
+protein NOUN B-LF
+kinase NOUN I-LF
+R PROPN I-LF
+( PUNCT O
+PKR PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+leads VERB O
+to ADP O
+translational ADJ O
+arrest NOUN O
+[ X O
+28 NUM O
+] PUNCT O
+and CCONJ O
+formation NOUN O
+of ADP O
+stress NOUN O
+granules NOUN O
+[ X O
+22,30 NUM O
+] PUNCT O
+. PUNCT O
+
+Significance ADJ O
+P NOUN O
+values NOUN O
+were AUX O
+calculated VERB O
+using VERB O
+Tukey PROPN O
+'s PART O
+multiple ADJ O
+comparison NOUN O
+test NOUN O
+. PUNCT O
+cont PROPN O
+, PUNCT O
+control NOUN O
+; PUNCT O
+Fgf7 PROPN B-AC
+, PUNCT O
+fibroblast NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+7 NUM I-LF
+; PUNCT O
+rhFGF7 PROPN B-AC
+, PUNCT O
+recombinant ADJ B-LF
+human ADJ I-LF
+FGF7 NOUN I-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+qPCR NOUN B-AC
+, PUNCT O
+reverse ADJ B-LF
+transcriptase NOUN I-LF
+- PUNCT I-LF
+quantitative ADJ I-LF
+PCR NOUN I-LF
+; PUNCT O
+Spp1 NOUN B-AC
+, PUNCT O
+secreted VERB B-LF
+phosphoprotein NOUN I-LF
+1 NUM I-LF
+. PUNCT O
+
+Dendritic ADJ B-LF
+cells NOUN I-LF
+( PUNCT O
+DCs PROPN B-AC
+) PUNCT O
+are AUX O
+regarded VERB O
+as ADP O
+the DET O
+most ADV O
+potent ADJ O
+antigen NOUN B-LF
+presenting VERB I-LF
+cells NOUN I-LF
+( PUNCT O
+APCs PROPN B-AC
+) PUNCT O
+for ADP O
+induction NOUN O
+of ADP O
+( PUNCT O
+cancer NOUN O
+) PUNCT O
+antigen NOUN O
+- PUNCT O
+specific ADJ O
+CD8 PROPN O
++ NOUN O
+T PROPN O
+cell NOUN O
+responses NOUN O
+. PUNCT O
+
+The DET O
+Self PROPN B-LF
+Reporting PROPN I-LF
+Questionnaire-20 PROPN I-LF
+( PUNCT O
+SRQ-20 NOUN B-AC
+) PUNCT O
+is AUX O
+a DET O
+WHO PROPN O
+- PUNCT O
+endorsed VERB O
+measure NOUN O
+of ADP O
+psychological ADJ O
+distress NOUN O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+. PUNCT O
+
+α NOUN B-LF
+- PUNCT I-LF
+Galactosylceramide NOUN I-LF
+( PUNCT O
+αGC PROPN B-AC
+) PUNCT O
+was AUX O
+purchased VERB O
+from ADP O
+Avanti PROPN O
+Polar PROPN O
+Lipids PROPN O
+. PUNCT O
+
+To PART O
+test VERB O
+this DET O
+hypothesis NOUN O
+, PUNCT O
+rats NOUN O
+were AUX O
+fed VERB O
+a DET O
+control NOUN B-LF
+diet NOUN I-LF
+( PUNCT O
+CD NOUN B-AC
+) PUNCT O
+or CCONJ O
+high ADJ O
+fat NOUN O
+isocaloric ADJ O
+diets NOUN O
+containing VERB O
+either CCONJ O
+ω-3 NUM O
+PUFA NOUN B-AC
+( PUNCT O
+FD NOUN B-AC
+) PUNCT O
+or CCONJ O
+lard NOUN O
+( PUNCT O
+LD NOUN B-AC
+) PUNCT O
+for ADP O
+6 NUM O
+weeks NOUN O
+. PUNCT O
+
+ChIP PROPN B-AC
+, PUNCT O
+chromatin NOUN B-LF
+immunoprecipitation NOUN I-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+QPCR PROPN B-AC
+, PUNCT O
+quantitative ADJ B-LF
+real ADJ I-LF
+- PUNCT I-LF
+time NOUN I-LF
+PCR NOUN I-LF
+. PUNCT O
+
+AV PROPN B-AC
+, PUNCT O
+animal NOUN B-LF
+– PUNCT I-LF
+vegetal NOUN I-LF
+; PUNCT O
+hpf NOUN B-AC
+, PUNCT O
+hours NOUN B-LF
+post X I-LF
+fertilization NOUN I-LF
+; PUNCT O
+pSmad5 PROPN B-AC
+, PUNCT O
+phosphorylated VERB B-LF
+Smad5 PROPN I-LF
+; PUNCT O
+WT PROPN O
+, PUNCT O
+wild ADJ O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+Current ADJ O
+clinical ADJ O
+trials NOUN O
+involving VERB O
+CAR PROPN B-AC
+T PROPN O
+cell NOUN O
+therapy NOUN O
+in ADP O
+GC PROPN B-AC
+patients NOUN O
+are AUX O
+targeting VERB O
+HER2 PROPN B-AC
+, PUNCT O
+CEA PROPN B-AC
+, PUNCT O
+Mucin-1 PROPN O
+, PUNCT O
+and CCONJ O
+epithelial ADJ B-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+( PUNCT O
+EpCAM PROPN B-AC
+) PUNCT O
+[ PUNCT O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+BHDS PROPN B-AC
+: PUNCT O
+Birt PROPN B-LF
+- PUNCT I-LF
+Hogg PROPN I-LF
+- PUNCT I-LF
+Dubé PROPN I-LF
+syndrome NOUN I-LF
+; PUNCT O
+COPD PROPN B-AC
+: PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+LAM PROPN B-AC
+: PUNCT O
+lymphangioleiomyomatosis NOUN B-LF
+. PUNCT O
+
+We PRON O
+used VERB O
+a DET O
+conservative ADJ O
+nonlinear ADJ O
+risk NOUN O
+relationship NOUN O
+generated VERB O
+using VERB O
+both CCONJ O
+ambient ADJ O
+and CCONJ O
+HAP PROPN B-AC
+studies NOUN O
+and CCONJ O
+with ADP O
+uncertainty NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+UIs NOUN B-AC
+) PUNCT O
+accounting VERB O
+for ADP O
+between ADP O
+- PUNCT O
+study NOUN O
+heterogeneity NOUN O
+in ADP O
+risk NOUN O
+estimates NOUN O
+. PUNCT O
+
+To PART O
+inform VERB O
+the DET O
+current ADJ O
+review NOUN O
+of ADP O
+this DET O
+legislation NOUN O
+, PUNCT O
+this DET O
+paper NOUN O
+aims VERB O
+to ADP O
+explore VERB O
+transnational ADJ B-LF
+tobacco NOUN I-LF
+company NOUN I-LF
+( PUNCT O
+TTC PROPN B-AC
+) PUNCT O
+interests NOUN O
+in ADP O
+SLT PROPN B-AC
+and CCONJ O
+pure ADJ O
+nicotine NOUN O
+in ADP O
+Europe PROPN O
+from ADP O
+the DET O
+1970s NOUN O
+to ADP O
+the DET O
+present NOUN O
+, PUNCT O
+comparing VERB O
+them PRON O
+with ADP O
+TTCs PROPN B-AC
+' PART O
+public ADJ O
+claims NOUN O
+of ADP O
+support NOUN O
+for ADP O
+harm NOUN O
+reduction NOUN O
+. PUNCT O
+
+MPA PROPN B-AC
+, PUNCT O
+marine NOUN B-LF
+protected VERB I-LF
+area NOUN I-LF
+. PUNCT O
+
+In ADP O
+a DET O
+sample NOUN O
+of ADP O
+1818 NUM O
+participants NOUN O
+( PUNCT O
+52 NUM O
+% NOUN O
+female ADJ O
+, PUNCT O
+mean ADJ O
+age NOUN O
+54±12 NUM O
+years NOUN O
+) PUNCT O
+global ADJ B-LF
+longitudinal ADJ I-LF
+peak NOUN I-LF
+systolic NOUN I-LF
+strain NOUN I-LF
+( PUNCT O
+GL PROPN B-AC
+- PUNCT B-AC
+PSS PROPN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+1218 NUM O
+) PUNCT O
+, PUNCT O
+systolic NOUN O
+( PUNCT O
+GL PROPN B-AC
+- PUNCT B-AC
+SSR PROPN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+1506 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+early ADJ O
+( PUNCT O
+GL PROPN B-AC
+- PUNCT B-AC
+EDSR PROPN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+1506 NUM O
+) PUNCT O
+and CCONJ O
+late ADJ O
+diastolic ADJ O
+strain NOUN O
+rates NOUN O
+( PUNCT O
+GL PROPN B-AC
+- PUNCT B-AC
+LDSR PROPN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+1500 NUM O
+) PUNCT O
+were AUX O
+derived VERB O
+from ADP O
+2D ADJ O
+speckle NOUN O
+tracking NOUN O
+analysis NOUN O
+. PUNCT O
+
+Here ADV O
+we PRON O
+distinguish VERB O
+2 NUM O
+types NOUN O
+of ADP O
+microcephaly NOUN O
+: PUNCT O
+morphological ADJ B-LF
+microcephaly NOUN I-LF
+( PUNCT O
+MM PROPN B-AC
+) PUNCT O
+and CCONJ O
+microcephaly NOUN O
+with ADP O
+structural ADJ O
+CNS PROPN B-AC
+defects NOUN O
+( PUNCT O
+hereafter ADV O
+termed VERB O
+microcephaly NOUN B-LF
+with ADP I-LF
+structural ADJ I-LF
+brain NOUN I-LF
+defects NOUN I-LF
+[ PUNCT O
+MWSD PROPN B-AC
+] PUNCT O
+) PUNCT O
+, PUNCT O
+originally ADV O
+reported VERB O
+as ADP O
+‘ PUNCT O
+suspected ADJ O
+microcephaly NOUN O
+’ PUNCT O
+and CCONJ O
+‘ PUNCT O
+confirmed VERB O
+microcephaly NOUN O
+’ PUNCT O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+We PRON O
+used VERB O
+the DET O
+International PROPN B-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+, PUNCT I-LF
+Ninth PROPN I-LF
+Revision PROPN I-LF
+, PUNCT I-LF
+Clinical PROPN I-LF
+Modification PROPN I-LF
+( PUNCT O
+ICD-9 PROPN B-AC
+- PUNCT B-AC
+CM PROPN B-AC
+) PUNCT O
+to PART O
+define VERB O
+preoperative ADJ O
+coexisting ADJ O
+medical ADJ O
+conditions NOUN O
+and CCONJ O
+postoperative ADJ O
+complications NOUN O
+. PUNCT O
+
+This DET O
+paper NOUN O
+reports VERB O
+on ADP O
+findings NOUN O
+from ADP O
+cluster NOUN O
+- PUNCT O
+randomized VERB O
+impact NOUN O
+evaluations NOUN O
+of ADP O
+two NUM O
+at ADP O
+- PUNCT O
+scale NOUN O
+programs NOUN O
+, PUNCT O
+in ADP O
+Bangladesh PROPN O
+and CCONJ O
+Viet PROPN O
+Nam PROPN O
+, PUNCT O
+that PRON O
+provided VERB O
+intensified VERB O
+interpersonal ADJ B-LF
+counseling NOUN I-LF
+( PUNCT O
+IPC PROPN B-AC
+) PUNCT O
+to PART O
+pregnant ADJ O
+women NOUN O
+and CCONJ O
+mothers NOUN O
+of ADP O
+children NOUN O
+up ADP O
+to PART O
+2 NUM O
+y NOUN O
+of ADP O
+age NOUN O
+, PUNCT O
+combined VERB O
+with ADP O
+mass NOUN B-LF
+media NOUN I-LF
+( PUNCT O
+MM PROPN B-AC
+) PUNCT O
+, PUNCT O
+community NOUN B-LF
+mobilization NOUN I-LF
+( PUNCT O
+CM PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+policy NOUN B-LF
+advocacy NOUN I-LF
+( PUNCT O
+PA PROPN B-AC
+) PUNCT O
+intervention NOUN O
+components NOUN O
+, PUNCT O
+to PART O
+improve VERB O
+breastfeeding NOUN O
+practices NOUN O
+[ PUNCT O
+20 NUM O
+] PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+d NOUN B-AC
+- NOUN B-AC
+ManNAc PROPN B-AC
+, PUNCT O
+N NOUN B-LF
+- NOUN I-LF
+acetyl NOUN I-LF
+- NOUN I-LF
+d NOUN I-LF
+- NOUN I-LF
+mannosamine NOUN I-LF
+; PUNCT O
+d NOUN B-AC
+- NOUN B-AC
+ManNAcA PROPN B-AC
+, PUNCT O
+N NOUN B-LF
+- NOUN I-LF
+acetyl NOUN I-LF
+- NOUN I-LF
+d NOUN I-LF
+- NOUN I-LF
+mannosaminuronic NOUN I-LF
+acid NOUN I-LF
+; PUNCT O
+ppm NOUN B-AC
+, PUNCT O
+parts NOUN B-LF
+per ADP I-LF
+million NUM I-LF
+. PUNCT O
+
+Protein NOUN B-LF
+kinase NOUN I-LF
+C PROPN I-LF
+( PUNCT O
+PKC PROPN B-AC
+) PUNCT O
+inhibitors NOUN O
+( PUNCT O
+Ro318425 PROPN O
+, PUNCT O
+Gö6983 PROPN O
+, PUNCT O
+Gö6976 PROPN O
+) PUNCT O
+targeting VERB O
+classical ADJ O
+and CCONJ O
+atypical ADJ O
+PKCs NOUN B-AC
+, PUNCT O
+and CCONJ O
+the DET O
+inhibitor NOUN O
+PKC412 PROPN O
+, PUNCT O
+which PRON O
+mainly ADV O
+inhibits VERB O
+classical ADJ O
+PKCs NOUN B-AC
+, PUNCT O
+all PRON O
+substantially ADV O
+blocked VERB O
+PKB PROPN B-AC
+/ SYM B-AC
+Akt PROPN B-AC
+phosphorylation NOUN O
+in ADP O
+response NOUN O
+to ADP O
+thapsigargin NOUN O
+and CCONJ O
+phorbol NOUN B-LF
+12 NUM I-LF
+- PUNCT I-LF
+myristate NOUN I-LF
+13 NUM I-LF
+- PUNCT I-LF
+acetate NOUN I-LF
+( PUNCT O
+PMA PROPN B-AC
+) PUNCT O
+( PUNCT O
+Figures NOUN O
+3A NUM O
+and CCONJ O
+S2A NOUN O
+) PUNCT O
+. PUNCT O
+Rottlerin PROPN O
+, PUNCT O
+with ADP O
+a DET O
+limited ADJ O
+selectivity NOUN O
+for ADP O
+PKCδ PROPN O
+, PUNCT O
+had VERB O
+no DET O
+effect NOUN O
+on ADP O
+PKB PROPN B-AC
+/ SYM B-AC
+Akt PROPN B-AC
+activation NOUN O
+. PUNCT O
+
+Fresh ADJ O
+and CCONJ O
+dried VERB O
+plant NOUN O
+extracts NOUN O
+of ADP O
+the DET O
+various ADJ O
+solvents NOUN O
+( PUNCT O
+aqueous NOUN O
+, PUNCT O
+acetone NOUN O
+& CCONJ O
+ethanol NOUN O
+) PUNCT O
+were AUX O
+weighed VERB O
+and CCONJ O
+dissolved VERB O
+in ADP O
+dimethyl NOUN B-LF
+sulfoxide NOUN I-LF
+( PUNCT O
+DMSO PROPN B-AC
+) PUNCT O
+. PUNCT O
+They PRON O
+were AUX O
+then ADV O
+all PRON O
+sonicated VERB O
+for ADP O
+proper ADJ O
+solubilization NOUN O
+and CCONJ O
+stored VERB O
+at ADP O
+-20 NUM O
+° NOUN O
+C NOUN O
+. PUNCT O
+
+Hemodynamics NOUN O
+including VERB O
+heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+HR NOUN B-AC
+) PUNCT O
+, PUNCT O
+AP PROPN B-AC
+, PUNCT O
+CO PROPN B-AC
+, PUNCT O
+LVAD NOUN B-AC
+flow NOUN O
+, PUNCT O
+RAP PROPN B-AC
+and CCONJ O
+LAP PROPN B-AC
+were AUX O
+recorded VERB O
+simultaneously ADV O
+. PUNCT O
+
+To PART O
+determine VERB O
+the DET O
+expression NOUN O
+of ADP O
+SmInAct PROPN B-AC
+at ADP O
+the DET O
+transcript NOUN O
+level NOUN O
+, PUNCT O
+real ADJ O
+- PUNCT O
+time NOUN O
+reverse ADJ B-LF
+transcriptase NOUN I-LF
+– PUNCT I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+RT PROPN B-AC
+- PUNCT B-AC
+PCR PROPN B-AC
+) PUNCT O
+was AUX O
+performed VERB O
+on ADP O
+cDNA NOUN O
+from ADP O
+eggs NOUN O
+, PUNCT O
+adult ADJ O
+male ADJ O
+parasites NOUN O
+, PUNCT O
+and CCONJ O
+adult ADJ O
+female ADJ O
+parasites NOUN O
+from ADP O
+mixed VERB O
+- PUNCT O
+sex NOUN O
+infections NOUN O
+. PUNCT O
+
+We PRON O
+also ADV O
+detected VERB O
+amplification NOUN O
+of ADP O
+both CCONJ O
+enabled ADJ O
+homolog NOUN O
+( PUNCT O
+ENAH PROPN B-AC
+) PUNCT O
+and CCONJ O
+poly NOUN B-LF
+[ PUNCT I-LF
+ADP NOUN I-LF
+- PUNCT I-LF
+ribose NOUN I-LF
+] PUNCT I-LF
+polymerase NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+PARP1 PROPN B-AC
+) PUNCT O
+in ADP O
+CH157 PROPN O
+- PUNCT O
+MN PROPN O
+, PUNCT O
+although SCONJ O
+these DET O
+genes NOUN O
+have AUX O
+not PART O
+previously ADV O
+been AUX O
+implicated VERB O
+in ADP O
+meningiomas NOUN O
+tumorigenesis NOUN O
+[ PUNCT O
+30 NUM O
+, PUNCT O
+31 NUM O
+] PUNCT O
+. PUNCT O
+
+Phagocytosis NOUN O
+of ADP O
+C.albicans NOUN O
+initializes VERB O
+apoptosis NOUN O
+in ADP O
+monocytes NOUN O
+( PUNCT O
+phagocytosis NOUN B-LF
+induced VERB I-LF
+cell NOUN I-LF
+death NOUN I-LF
+, PUNCT O
+PICD PROPN B-AC
+) PUNCT O
+. PUNCT O
+PICD PROPN B-AC
+is AUX O
+reduced VERB O
+in ADP O
+neonatal ADJ O
+cord NOUN O
+blood NOUN O
+monocytes NOUN O
+( PUNCT O
+CBMO PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+HSR PROPN B-AC
+, PUNCT O
+Health NOUN B-LF
+Star NOUN I-LF
+Rating NOUN I-LF
+; PUNCT O
+NZ PROPN B-AC
+, PUNCT O
+New PROPN B-LF
+Zealand PROPN I-LF
+. PUNCT O
+
+DN PROPN B-AC
+, PUNCT O
+dominant NOUN B-LF
+- PUNCT I-LF
+negative ADJ I-LF
+; PUNCT O
+EC PROPN B-AC
+, PUNCT O
+endothelial ADJ B-LF
+cell NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+hpf NOUN B-AC
+, PUNCT O
+hours NOUN B-LF
+post X I-LF
+fertilization NOUN I-LF
+; PUNCT O
+HS PROPN B-AC
+, PUNCT O
+heat NOUN B-LF
+shock NOUN I-LF
+; PUNCT O
+n.s X O
+. PUNCT O
+, PUNCT O
+nonsignificant ADJ O
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+TF PROPN B-AC
+, PUNCT O
+transferrin NOUN B-LF
+; PUNCT O
+TRITC PROPN B-AC
+, PUNCT O
+tetramethylrhodamine NOUN B-LF
+; PUNCT O
+WISH NOUN B-AC
+, PUNCT O
+whole ADJ B-LF
+- PUNCT I-LF
+mount NOUN I-LF
+in ADP I-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+
+Fat NOUN B-LF
+- PUNCT I-LF
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+mass NOUN I-LF
+( PUNCT O
+FFM PROPN B-AC
+) PUNCT O
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+calculated VERB O
+as ADP O
+the DET O
+difference NOUN O
+between ADP O
+body NOUN O
+mass NOUN O
+and CCONJ O
+fat NOUN O
+mass NOUN O
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+
+OPCE PROPN B-AC
+, PUNCT O
+overall ADJ B-LF
+patient NOUN I-LF
+- PUNCT I-LF
+centered VERB I-LF
+primary ADJ I-LF
+care NOUN I-LF
+experience NOUN I-LF
+; PUNCT O
+PC PROPN B-AC
+, PUNCT O
+primary ADJ B-LF
+care NOUN I-LF
+; PUNCT O
+SRH PROPN B-AC
+, PUNCT O
+self NOUN B-LF
+- PUNCT I-LF
+rated VERB I-LF
+health NOUN I-LF
+. PUNCT O
+
+Spinal ADJ B-LF
+anesthesia NOUN I-LF
+( PUNCT O
+SA PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+form NOUN O
+of ADP O
+regional ADJ O
+anesthesia NOUN O
+( PUNCT O
+RA PROPN O
+) PUNCT O
+used VERB O
+frequently ADV O
+in ADP O
+various ADJ O
+lower ADJ O
+abdominal ADJ O
+, PUNCT O
+orthopedic ADJ O
+, PUNCT O
+and CCONJ O
+obstetric ADJ O
+operations NOUN O
+, PUNCT O
+including VERB O
+cesarean ADJ B-LF
+delivery NOUN I-LF
+( PUNCT O
+CD NOUN B-AC
+) PUNCT O
+[ PUNCT O
+1–4 NUM O
+] PUNCT O
+. PUNCT O
+
+There PRON O
+is VERB O
+a DET O
+high ADJ O
+level NOUN O
+of ADP O
+variability NOUN O
+in ADP O
+the DET O
+reported VERB O
+mortality NOUN O
+of ADP O
+PARDS NOUN B-AC
+[ X O
+28,29 NUM O
+] PUNCT O
+ranging VERB O
+from ADP O
+11.3 NUM O
+% NOUN O
+in ADP O
+a DET O
+study NOUN O
+including VERB O
+children NOUN O
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+acute ADJ B-LF
+lung NOUN I-LF
+injury NOUN I-LF
+( PUNCT O
+ALI PROPN B-AC
+) PUNCT O
+[ X O
+30 NUM O
+] PUNCT O
+to ADP O
+76.5 NUM O
+% NOUN O
+in ADP O
+a DET O
+study NOUN O
+of ADP O
+children NOUN O
+who PRON O
+have AUX O
+undergone VERB O
+haematopoietic ADJ O
+stem NOUN O
+cell NOUN O
+transplant NOUN O
+[ X O
+31 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+aim NOUN O
+of ADP O
+this DET O
+study NOUN O
+was AUX O
+to PART O
+investigate VERB O
+whether SCONJ O
+extracellular ADJ O
+vesicles NOUN O
+( PUNCT O
+EVs NOUN B-AC
+) PUNCT O
+produced VERB O
+by ADP O
+human ADJ O
+renal ADJ B-LF
+proximal ADJ I-LF
+tubular ADJ I-LF
+epithelial ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+RPTECs PROPN B-AC
+) PUNCT O
+may AUX O
+induce VERB O
+mesenchymal ADJ O
+- PUNCT O
+epithelial ADJ O
+transition NOUN O
+of ADP O
+bone NOUN O
+marrow NOUN O
+- PUNCT O
+derived VERB O
+mesenchymal ADJ B-LF
+stromal ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+MSCs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Adaptation NOUN O
+was AUX O
+less ADV O
+evident ADJ O
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+the DET O
+pelvis NOUN O
+at ADP O
+HF PROPN B-AC
+. PUNCT O
+For ADP O
+each DET O
+participant NOUN O
+and CCONJ O
+condition NOUN O
+, PUNCT O
+the DET O
+values NOUN O
+of ADP O
+the DET O
+amplitude NOUN O
+of ADP O
+the DET O
+head NOUN O
+and CCONJ O
+pelvis NOUN O
+PP NOUN B-AC
+displacements NOUN O
+over ADP O
+the DET O
+successive ADJ O
+cycles NOUN O
+were AUX O
+fitted VERB O
+with ADP O
+an DET O
+exponential ADJ O
+function NOUN O
+and CCONJ O
+the DET O
+time NOUN O
+constant NOUN O
+and CCONJ O
+adaptation NOUN B-LF
+index NOUN I-LF
+( PUNCT O
+AI PROPN B-AC
+) PUNCT O
+estimated VERB O
+. PUNCT O
+
+The DET O
+primers NOUN O
+used VERB O
+were AUX O
+as SCONJ O
+follows VERB O
+: PUNCT O
+GAPDH NOUN O
+( PUNCT O
+forward NOUN O
+, PUNCT O
+5’-ATC NUM O
+ACC PROPN O
+ATC PROPN O
+TTC PROPN O
+CAG PROPN O
+GAG PROPN O
+CGA-3 PROPN O
+’ NOUN O
+; PUNCT O
+reverse NOUN O
+, PUNCT O
+5’-TTC NOUN O
+TCC PROPN O
+ATG PROPN O
+GTG PROPN O
+GTG PROPN O
+AAG PROPN O
+ACG-3 PROPN O
+’ NOUN O
+) PUNCT O
+, PUNCT O
+collagen NOUN B-LF
+1A1 NOUN I-LF
+( PUNCT O
+COL1A1 NOUN B-AC
+; PUNCT O
+forward NOUN O
+, PUNCT O
+5’-AAG NOUN O
+GTG PROPN O
+CTG PROPN O
+ATG PROPN O
+GCT PROPN O
+CTC PROPN O
+CT-3 PROPN O
+’ NOUN O
+; PUNCT O
+reverse NOUN O
+, PUNCT O
+5’-CTG NOUN O
+GGA PROPN O
+CCA PROPN O
+CTT PROPN O
+TCA PROPN O
+CCC PROPN O
+TT-3 PROPN O
+’ NOUN O
+) PUNCT O
+, PUNCT O
+collagen NOUN B-LF
+1A2 NUM I-LF
+( PUNCT O
+COL1A2 PROPN B-AC
+; PUNCT O
+forward NOUN O
+, PUNCT O
+5’-GAA NOUN O
+AGA PROPN O
+AGG PROPN O
+GCT PROPN O
+TCG PROPN O
+TGG PROPN O
+TC-3 PROPN O
+’ NOUN O
+; PUNCT O
+reverse NOUN O
+, PUNCT O
+5’-CAG NOUN O
+CAG PROPN O
+TAC PROPN O
+CAG PROPN O
+CCT PROPN O
+CTC PROPN O
+CA-3 PROPN O
+’ NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+collagen NOUN B-LF
+3A1 NUM I-LF
+( PUNCT O
+COL3A1 NOUN B-AC
+; PUNCT O
+forward NOUN O
+, PUNCT O
+5’-AGG NOUN O
+TCC PROPN O
+TGC PROPN O
+GGG PROPN O
+TAA PROPN O
+CAC PROPN O
+T-3 PROPN O
+’ NOUN O
+; PUNCT O
+reverse NOUN O
+, PUNCT O
+5’-ACT NUM O
+TTC PROPN O
+ACC PROPN O
+CTT PROPN O
+GAC PROPN O
+ACC PROPN O
+CTG-3 PROPN O
+’ NOUN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+order NOUN O
+to ADP O
+address VERB O
+this PRON O
+, PUNCT O
+we PRON O
+solved VERB O
+the DET O
+structure NOUN O
+of ADP O
+the DET O
+Lifeact PROPN O
+– PUNCT O
+F PROPN B-AC
+- NOUN B-AC
+actin NOUN B-AC
+complex NOUN O
+using VERB O
+cryo NOUN B-AC
+- NOUN B-AC
+EM PROPN B-AC
+. PUNCT O
+The DET O
+3.5 NUM O
+Å NOUN O
+structure NOUN O
+reveals VERB O
+that SCONJ O
+Lifeact PROPN O
+binds VERB O
+to ADP O
+2 NUM O
+consecutive ADJ O
+actin NOUN O
+subunits NOUN O
+of ADP O
+the DET O
+same ADJ O
+strand NOUN O
+of ADP O
+the DET O
+filament NOUN O
+and CCONJ O
+displaces VERB O
+the DET O
+DNase PROPN B-LF
+I NOUN I-LF
+– PUNCT I-LF
+binding VERB I-LF
+loop NOUN I-LF
+( PUNCT O
+D NOUN B-AC
+- NOUN B-AC
+loop NOUN B-AC
+) PUNCT O
+upon SCONJ O
+binding VERB O
+. PUNCT O
+
+HV PROPN B-AC
+- PUNCT O
+Hepatic NOUN B-LF
+vein NOUN I-LF
+, PUNCT O
+ICL PROPN B-AC
+- PUNCT O
+inferior ADJ B-LF
+caudate ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+MML PROPN B-AC
+- PUNCT O
+middle ADJ B-LF
+median ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+LML PROPN B-AC
+- PUNCT O
+left ADJ B-LF
+median ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+LLL PROPN B-AC
+- PUNCT O
+left ADJ B-LF
+lateral ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+PV NOUN B-AC
+- PUNCT O
+portal ADJ B-LF
+vein NOUN I-LF
+, PUNCT O
+RIL PROPN B-AC
+- PUNCT O
+right ADJ B-LF
+inferior ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+RML PROPN B-AC
+- PUNCT O
+right ADJ B-LF
+median ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+RSL PROPN B-AC
+- PUNCT O
+right ADJ B-LF
+superior ADJ I-LF
+lobe NOUN I-LF
+, PUNCT O
+SCL NOUN B-AC
+- PUNCT O
+superior ADJ B-LF
+caudate ADJ I-LF
+lobe NOUN I-LF
+. PUNCT O
+
+AA PROPN B-AC
+, PUNCT O
+arachidonic ADJ B-LF
+acid NOUN I-LF
+; PUNCT O
+AEA PROPN B-AC
+, PUNCT O
+N NOUN B-LF
+- PUNCT I-LF
+arachidonoylethanolamide NOUN I-LF
+; PUNCT O
+PEA PROPN B-AC
+, PUNCT O
+palmitoylethanolamide NOUN B-LF
+. PUNCT O
+
+SNP NOUN B-AC
+, PUNCT O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphism NOUN I-LF
+; PUNCT O
+UTR NOUN B-AC
+, PUNCT O
+untranslated VERB B-LF
+region NOUN I-LF
+. PUNCT O
+
+We PRON O
+employed VERB O
+a DET O
+monoclonal ADJ B-LF
+antibody NOUN I-LF
+( PUNCT O
+mAb NOUN B-AC
+659 NUM O
+) PUNCT O
+specific ADJ O
+for ADP O
+the DET O
+unique ADJ O
+and CCONJ O
+intact ADJ O
+thrombin NOUN O
+- PUNCT O
+sensitive ADJ O
+site NOUN O
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+inhibition NOUN O
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+. PUNCT O
+We PRON O
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+significantly ADV O
+higher ADJ O
+levels NOUN O
+of ADP O
+OPN PROPN B-AC
+in ADP O
+33 NUM O
+cervical ADJ O
+cancer NOUN O
+patients NOUN O
+in ADP O
+both CCONJ O
+the DET O
+plasma NOUN O
+( PUNCT O
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++ ADJ O
+/- ADJ O
+SD NOUN O
+, PUNCT O
+612 NUM O
++ ADJ O
+/- ADJ O
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+mL NOUN O
+) PUNCT O
+and CCONJ O
+serum NOUN O
+( PUNCT O
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++ ADJ O
+/- ADJ O
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+/ NOUN O
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+) PUNCT O
+compared VERB O
+to ADP O
+healthy ADJ O
+subjects NOUN O
+[ PUNCT O
+409 NUM O
++ ADJ O
+/- ADJ O
+56 NUM O
+ng NOUN O
+/ NOUN O
+mL NOUN O
+, PUNCT O
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+31 NUM O
+plasma NOUN O
+samples NOUN O
+( PUNCT O
+P NOUN O
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+0.0001 NUM O
+) PUNCT O
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++ ADJ O
+/- ADJ O
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+ng NOUN O
+/ NOUN O
+mL NOUN O
+, PUNCT O
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+32 NUM O
+serum NOUN O
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+( PUNCT O
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+= SYM O
+0.0002 NUM O
+) PUNCT O
+, PUNCT O
+respectively ADV O
+] PUNCT O
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+
+Adverse ADJ B-LF
+events NOUN I-LF
+( PUNCT O
+AEs NOUN B-AC
+) PUNCT O
+and CCONJ O
+serious ADJ B-LF
+adverse ADJ I-LF
+events NOUN I-LF
+( PUNCT O
+SAEs NOUN B-AC
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+drug NOUN O
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+and CCONJ O
+treatment NOUN O
+group NOUN O
+. PUNCT O
+
+WT PROPN B-AC
+, PUNCT O
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+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Both CCONJ O
+healthy ADJ O
+volunteers NOUN O
+and CCONJ O
+trauma NOUN O
+patients NOUN O
+were AUX O
+enrolled VERB O
+and CCONJ O
+consented VERB O
+under ADP O
+an DET O
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+Virginia PROPN B-LF
+Commonwealth PROPN I-LF
+University PROPN I-LF
+( PUNCT O
+VCU PROPN B-AC
+) PUNCT O
+IRB PROPN B-AC
+protocol NOUN O
+. PUNCT O
+
+ITT PROPN O
+, PUNCT O
+intention NOUN O
+to PART O
+treat VERB O
+; PUNCT O
+RE PROPN B-AC
+, PUNCT O
+reinforced VERB B-LF
+education NOUN I-LF
+; PUNCT O
+SE PROPN B-AC
+, PUNCT O
+standard ADJ B-LF
+education NOUN I-LF
+; PUNCT O
+BP PROPN B-AC
+, PUNCT O
+bowel NOUN B-LF
+preparation NOUN I-LF
+; PUNCT O
+RCT NOUN B-AC
+, PUNCT O
+randomized ADJ B-LF
+controlled ADJ I-LF
+trial NOUN I-LF
+; PUNCT O
+SMS NOUN B-AC
+, PUNCT O
+short ADJ B-LF
+message NOUN I-LF
+service NOUN I-LF
+; PUNCT O
+NR NOUN O
+, PUNCT O
+not PART O
+reported VERB O
+
+Based VERB O
+on ADP O
+cell NOUN O
+cycle NOUN O
+– PUNCT O
+dependent ADJ O
+degradation NOUN O
+of ADP O
+chromatin NOUN B-LF
+licensing NOUN I-LF
+and CCONJ I-LF
+DNA NOUN I-LF
+replication NOUN I-LF
+factor NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+CDT1 PROPN B-AC
+) PUNCT O
+and CCONJ O
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+DNA NOUN I-LF
+replication NOUN I-LF
+inhibitor NOUN I-LF
+( PUNCT O
+GEMININ PROPN B-AC
+) PUNCT O
+proteins NOUN O
+, PUNCT O
+cells NOUN O
+show VERB O
+no DET O
+color NOUN O
+in ADP O
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+G1 PROPN O
+, PUNCT O
+red ADJ O
+in ADP O
+mid ADJ O
+/ SYM O
+late ADJ O
+G1 PROPN O
+, PUNCT O
+and CCONJ O
+green NOUN O
+in ADP O
+S NOUN O
+/ SYM O
+G2 NOUN O
+/ SYM O
+M NOUN O
+( PUNCT O
+S1A PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+All DET O
+single ADJ B-LF
+nucleotide NOUN I-LF
+variants NOUN I-LF
+( PUNCT O
+SNVs NOUN B-AC
+) PUNCT O
+and CCONJ O
+insertions NOUN O
+and CCONJ O
+deletions NOUN O
+( PUNCT O
+InDels NOUN B-AC
+) PUNCT O
+detected VERB O
+through ADP O
+bioinformatics NOUN O
+analysis NOUN O
+underwent VERB O
+visual ADJ O
+inspection NOUN O
+using VERB O
+the DET O
+IGV PROPN B-AC
+for ADP O
+confirmation NOUN O
+. PUNCT O
+
+Secondly ADV O
+, PUNCT O
+we PRON O
+employed VERB O
+a DET O
+correlation NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+feature NOUN I-LF
+selection NOUN I-LF
+( PUNCT O
+CFS PROPN B-AC
+) PUNCT O
+algorithm NOUN O
+[ PUNCT O
+16]-a NUM O
+WEKA PROPN O
+[ PUNCT O
+17 NUM O
+] X O
+tool NOUN O
+. PUNCT O
+
+Immunostained ADJ O
+serial ADJ O
+retinal ADJ O
+sections NOUN O
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+each PRON O
+divided VERB O
+into ADP O
+four NUM O
+regions NOUN O
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+to ADP O
+the DET O
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+nerve NOUN O
+and CCONJ O
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+( PUNCT O
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+SUP PROPN B-AC
+) PUNCT O
+, PUNCT O
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+( PUNCT O
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+) PUNCT O
+, PUNCT O
+superior ADJ B-LF
+optic ADJ I-LF
+nerve NOUN I-LF
+( PUNCT O
+SUP PROPN B-AC
+ON PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+inferior ADJ B-LF
+optic ADJ I-LF
+nerve NOUN I-LF
+( PUNCT O
+INF PROPN B-AC
+ON PROPN B-AC
+) PUNCT O
+. PUNCT O
+Each DET O
+region NOUN O
+was AUX O
+assigned VERB O
+a DET O
+percent NOUN O
+transduction NOUN O
+score NOUN O
+by ADP O
+an DET O
+independent ADJ O
+observer NOUN O
+that PRON O
+was AUX O
+based VERB O
+on ADP O
+the DET O
+number NOUN O
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+GFP PROPN B-AC
+- PUNCT O
+positive ADJ O
+cells NOUN O
+within ADP O
+the DET O
+region NOUN O
+. PUNCT O
+
+Semi ADJ O
+- PUNCT O
+structured ADJ O
+in ADP B-LF
+- PUNCT I-LF
+depth NOUN I-LF
+interview NOUN I-LF
+( PUNCT O
+IDI NOUN B-AC
+) PUNCT O
+guiding VERB O
+questions NOUN O
+were AUX O
+used VERB O
+. PUNCT O
+
+HRVT2 PROPN B-AC
+- PUNCT B-AC
+HFP PROPN B-AC
+& CCONJ B-AC
+HRVT2 PROPN B-AC
+- PUNCT B-AC
+HFP PROPN B-AC
+- PUNCT B-AC
+RSA PROPN B-AC
+= VERB O
+heart NOUN O
+rate NOUN O
+variability NOUN O
+thresholds NOUN O
+as SCONJ O
+determined VERB O
+from ADP O
+the DET O
+high ADJ O
+frequency NOUN O
+power NOUN O
+and CCONJ O
+from ADP O
+the DET O
+high ADJ O
+frequency NOUN O
+power NOUN O
+component NOUN O
+related VERB O
+to ADP O
+respiratory ADJ B-LF
+sinus NOUN I-LF
+arrhythmia NOUN I-LF
+, PUNCT O
+respectively ADV O
+; PUNCT O
+VT2 PROPN O
+= VERB O
+second ADJ O
+Ventilatory ADJ O
+threshold NOUN O
+. PUNCT O
+
+The DET O
+aim NOUN O
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+the DET O
+present ADJ O
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+trial NOUN I-LF
+( PUNCT O
+RCT PROPN B-AC
+) PUNCT O
+was AUX O
+to PART O
+determine VERB O
+the DET O
+impact NOUN O
+of ADP O
+such DET O
+a DET O
+patient NOUN O
+- PUNCT O
+centred VERB O
+approach NOUN O
+in ADP O
+CMR PROPN B-AC
+on ADP O
+patients NOUN O
+' PART O
+lives NOUN O
+, PUNCT O
+including VERB O
+HR NOUN B-AC
+- PUNCT B-AC
+QoL NOUN B-AC
+and CCONJ O
+health NOUN O
+problems NOUN O
+. PUNCT O
+
+It PRON O
+is AUX O
+common ADJ O
+for ADP O
+chiropractors NOUN O
+to PART O
+recommend VERB O
+“ PUNCT O
+maintenance NOUN B-LF
+care NOUN I-LF
+( PUNCT O
+MC PROPN B-AC
+) PUNCT O
+” PUNCT O
+, PUNCT O
+i.e. X O
+preventive ADJ O
+consultations NOUN O
+/ SYM O
+visits NOUN O
+for ADP O
+recurrent ADJ O
+and CCONJ O
+persistent ADJ O
+musculoskeletal ADJ O
+pain NOUN O
+and CCONJ O
+dysfunction NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+CFT NOUN B-AC
+, PUNCT O
+clot NOUN B-LF
+formation NOUN I-LF
+time NOUN I-LF
+; PUNCT O
+CT PROPN B-AC
+, PUNCT O
+clotting NOUN B-LF
+time NOUN I-LF
+; PUNCT O
+MCF PROPN B-AC
+, PUNCT O
+maximum ADJ B-LF
+clot NOUN I-LF
+firmness NOUN I-LF
+; PUNCT O
+ML NOUN B-AC
+, PUNCT O
+maximum ADJ B-LF
+lysis NOUN I-LF
+
+COPD NOUN B-AC
+, PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+. PUNCT O
+
+A DET O
+hallmark NOUN O
+of ADP O
+such ADJ O
+proteins NOUN O
+is AUX O
+the DET O
+presence NOUN O
+of ADP O
+a DET O
+130 NUM O
+- PUNCT O
+aa NOUN O
+Su(var NOUN B-LF
+) PUNCT I-LF
+, PUNCT I-LF
+Enhancer NOUN I-LF
+of ADP I-LF
+zeste NOUN I-LF
+, PUNCT I-LF
+Trithorax NOUN I-LF
+( PUNCT O
+SET PROPN B-AC
+) PUNCT O
+domain NOUN O
+. PUNCT O
+
+AF PROPN B-AC
+, PUNCT O
+atrial ADJ B-LF
+fibrillation NOUN I-LF
+; PUNCT O
+KMD PROPN B-AC
+, PUNCT O
+Kardia PROPN B-LF
+Mobile PROPN I-LF
+Device PROPN I-LF
+; PUNCT O
+SLECG PROPN B-AC
+, PUNCT O
+single ADJ B-LF
+- PUNCT I-LF
+lead NOUN I-LF
+ECG NOUN I-LF
+. PUNCT O
+
+Schisandra PROPN B-LF
+chinensis NOUN I-LF
+extracts NOUN I-LF
+( PUNCT O
+SEs NOUN B-AC
+) PUNCT O
+have AUX O
+traditionally ADV O
+been AUX O
+used VERB O
+as ADP O
+an DET O
+oriental ADJ O
+medicine NOUN O
+for ADP O
+the DET O
+treatment NOUN O
+of ADP O
+various ADJ O
+human ADJ O
+diseases NOUN O
+, PUNCT O
+however ADV O
+, PUNCT O
+their PRON O
+further ADJ O
+application NOUN O
+in ADP O
+the DET O
+biocontrol NOUN O
+of ADP O
+plant NOUN O
+disease NOUN O
+remains VERB O
+poorly ADV O
+understood VERB O
+. PUNCT O
+
+The DET O
+cDNA NOUN O
+encoding VERB O
+the DET O
+chimp NOUN O
+AR PROPN B-AC
+LBD PROPN B-AC
+( PUNCT O
+residues NOUN O
+663–919 NUM O
+— PUNCT O
+human ADJ O
+numbering NOUN O
+) PUNCT O
+, PUNCT O
+which PRON O
+displays VERB O
+100 NUM O
+% NOUN O
+identity NOUN O
+to ADP O
+the DET O
+human ADJ O
+form NOUN O
+in ADP O
+protein NOUN O
+sequence NOUN O
+, PUNCT O
+was AUX O
+cloned VERB O
+into ADP O
+a DET O
+modified VERB O
+pGEX-2 PROPN O
+T PROPN O
+vector NOUN O
+( PUNCT O
+Amersham PROPN O
+Biosciences PROPN O
+, PUNCT O
+Piscataway PROPN O
+, PUNCT O
+New PROPN O
+Jersey PROPN O
+, PUNCT O
+United PROPN O
+States PROPN O
+) PUNCT O
+and CCONJ O
+expressed VERB O
+as ADP O
+glutathione NOUN B-LF
+S PROPN I-LF
+- PROPN I-LF
+transferase NOUN I-LF
+( PUNCT O
+GST PROPN B-AC
+) PUNCT O
+fusion NOUN O
+protein NOUN O
+in ADP O
+the DET O
+E. PROPN O
+coli PROPN O
+strain NOUN O
+BL21 PROPN O
+( PUNCT O
+DE3 PROPN O
+) PUNCT O
+STAR PROPN O
+in ADP O
+the DET O
+presence NOUN O
+of ADP O
+10 NUM O
+μM NOUN O
+DHT PROPN B-AC
+. PUNCT O
+Induction NOUN O
+was AUX O
+carried VERB O
+out ADP O
+with ADP O
+30 NUM O
+μM NOUN O
+IPTG PROPN O
+at ADP O
+17 NUM O
+° NOUN O
+C NOUN O
+for ADP O
+16–18 NUM O
+h. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+NMVOC PROPN B-AC
+, PUNCT O
+non ADJ B-LF
+- ADJ I-LF
+methane ADJ I-LF
+volatile ADJ I-LF
+organic ADJ I-LF
+compound NOUN I-LF
+. PUNCT O
+
+The DET O
+terms NOUN O
+used VERB O
+were AUX O
+“ PUNCT O
+Killer PROPN B-LF
+Immunoglobulin PROPN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+Receptor PROPN I-LF
+” PUNCT O
+, PUNCT O
+‘ PUNCT O
+KIR PROPN B-AC
+” PUNCT O
+, PUNCT O
+“ PUNCT O
+HIV PROPN B-AC
+” PUNCT O
+, PUNCT O
+“ PUNCT O
+Human PROPN B-LF
+Immunodeficiency PROPN I-LF
+Virus PROPN I-LF
+” PUNCT O
+, PUNCT O
+“ PUNCT O
+HESN PROPN B-AC
+” PUNCT O
+“ PUNCT O
+HIV PROPN B-AC
+- PUNCT O
+exposed VERB O
+seronegative NOUN O
+” PUNCT O
+as ADP O
+medical ADJ O
+subject NOUN O
+headings NOUN O
+and CCONJ O
+text NOUN O
+, PUNCT O
+without ADP O
+language NOUN O
+restrictions NOUN O
+. PUNCT O
+
+The DET O
+method NOUN O
+of ADP O
+creating VERB O
+cancer NOUN B-LF
+tissue NOUN I-LF
+originated VERB I-LF
+spheroid NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+CTOS PROPN B-AC
+) PUNCT O
+is AUX O
+the DET O
+most ADV O
+powerful ADJ O
+technology NOUN O
+to PART O
+evaluate VERB O
+such DET O
+a DET O
+mouse NOUN O
+model NOUN O
+[ PUNCT O
+47 NUM O
+] PUNCT O
+. PUNCT O
+
+Only ADV O
+two NUM O
+proteins NOUN O
+, PUNCT O
+S100 NOUN B-LF
+calcium NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+A9 PROPN I-LF
+( PUNCT O
+S100a9 PROPN B-AC
+) PUNCT O
+and CCONJ O
+transthyretin NOUN B-LF
+( PUNCT O
+Ttr NOUN B-AC
+) PUNCT O
+which PRON O
+are AUX O
+involved ADJ O
+in ADP O
+calcium NOUN O
+signaling NOUN O
+and CCONJ O
+the DET O
+extracellular ADJ O
+region NOUN O
+, PUNCT O
+respectively ADV O
+, PUNCT O
+were AUX O
+commonly ADV O
+regulated VERB O
+by ADP O
+three NUM O
+different ADJ O
+treatments NOUN O
+. PUNCT O
+
+In ADP O
+contrast NOUN O
+, PUNCT O
+the DET O
+hypothesis NOUN O
+of ADP O
+an DET O
+unliganded ADJ O
+AncNR PROPN B-AC
+can AUX O
+explain VERB O
+the DET O
+structure NOUN O
+- PUNCT O
+function NOUN O
+relations NOUN O
+of ADP O
+only ADV O
+a DET O
+single ADJ O
+NR NOUN O
+as ADP O
+due ADJ O
+to PART O
+descent NOUN O
+from ADP O
+the DET O
+ancestral ADJ B-LF
+NR NOUN I-LF
+; PUNCT O
+it PRON O
+requires VERB O
+the DET O
+ancestral ADJ O
+basis NOUN O
+for ADP O
+ligand NOUN O
+- PUNCT O
+independent ADJ O
+activity NOUN O
+to PART O
+have AUX O
+been AUX O
+independently ADV O
+lost VERB O
+and CCONJ O
+replaced VERB O
+with ADP O
+different ADJ O
+underlying VERB O
+mechanisms NOUN O
+in ADP O
+all DET O
+other ADJ O
+lineages NOUN O
+of ADP O
+ligand NOUN O
+- PUNCT O
+independent ADJ O
+receptors NOUN O
+and CCONJ O
+the DET O
+shared VERB O
+mechanisms NOUN O
+for ADP O
+ligand NOUN O
+- PUNCT O
+dependent ADJ O
+activation NOUN O
+to PART O
+have AUX O
+been AUX O
+gained VERB O
+independently ADV O
+in ADP O
+the DET O
+many ADJ O
+lineages NOUN O
+of ADP O
+liganded ADJ O
+receptors NOUN O
+. PUNCT O
+
+The DET B-AC
+fracture NOUN O
+is AUX O
+viewed VERB O
+as ADP O
+a DET O
+tube NOUN O
+with ADP O
+a DET O
+rectangular ADJ O
+cross NOUN O
+- PUNCT O
+section NOUN O
+, PUNCT O
+and CCONJ O
+its PRON O
+hfr NOUN B-AC
+is AUX O
+calculated VERB O
+by ADP O
+[ PUNCT O
+26 NUM O
+] PUNCT O
+: PUNCT O
+hfr NOUN B-AC
+= X O
+Nufr⋅λWdfr(25 NOUN O
+) PUNCT O
+where SCONJ O
+dfr NOUN B-AC
+is AUX O
+the DET O
+equivalent ADJ O
+diameter NOUN O
+of ADP O
+the DET O
+fracture NOUN O
+tube NOUN O
+, PUNCT O
+and CCONJ O
+Nufr PROPN O
+is AUX O
+the DET O
+Nusselt PROPN O
+number NOUN O
+which PRON O
+is AUX O
+calculated VERB O
+by ADP O
+the DET O
+Dittus PROPN O
+- PUNCT O
+Boelter PROPN O
+Equation NOUN O
+[ PUNCT O
+26 NUM O
+] PUNCT O
+: PUNCT O
+Nufr=0.023Refr0.8Pr0.3(26 NUM O
+) PUNCT O
+where SCONJ O
+Refr X B-AC
+is AUX O
+the DET O
+Reynolds PROPN B-LF
+number NOUN I-LF
+of ADP I-LF
+flow NOUN I-LF
+in ADP I-LF
+the DET I-LF
+fracture NOUN I-LF
+, PUNCT O
+which PRON O
+is AUX O
+given VERB O
+by ADP O
+: PUNCT O
+Refr X B-AC
+= X O
+uwdfrνw(27 X O
+) PUNCT O
+
+An DET O
+incremental ADJ O
+cost NOUN O
+- PUNCT O
+utility NOUN O
+analysis NOUN O
+using VERB O
+a DET O
+Markov PROPN O
+model NOUN O
+was AUX O
+performed VERB O
+comparing VERB O
+guaiac PROPN O
+- PUNCT O
+based VERB O
+fecal ADJ B-LF
+occult ADJ I-LF
+blood NOUN I-LF
+test NOUN I-LF
+( PUNCT O
+FOBT PROPN B-AC
+) PUNCT O
+or CCONJ O
+fecal ADJ B-LF
+immunochemical ADJ I-LF
+test NOUN I-LF
+( PUNCT O
+FIT PROPN B-AC
+) PUNCT O
+annually ADV O
+, PUNCT O
+fecal ADJ O
+DNA NOUN O
+every DET O
+3 NUM O
+years NOUN O
+, PUNCT O
+flexible ADJ O
+sigmoidoscopy NOUN O
+or CCONJ O
+computed VERB O
+tomographic ADJ O
+colonography NOUN O
+every DET O
+5 NUM O
+years NOUN O
+, PUNCT O
+and CCONJ O
+colonoscopy NOUN O
+every DET O
+10 NUM O
+years NOUN O
+. PUNCT O
+
+Baseline ADJ O
+clinical ADJ O
+variables NOUN O
+, PUNCT O
+including VERB O
+age NOUN O
+, PUNCT O
+gender NOUN O
+, PUNCT O
+CF PROPN B-AC
+genotype NOUN O
+, PUNCT O
+pancreatic ADJ O
+insufficiency NOUN O
+, PUNCT O
+CF PROPN B-AC
+- PUNCT O
+related VERB O
+diabetes NOUN O
+and/or CCONJ O
+liver NOUN O
+disease NOUN O
+, PUNCT O
+body NOUN B-LF
+- PUNCT I-LF
+mass NOUN I-LF
+- PUNCT I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+at ADP O
+the DET O
+time NOUN O
+of ADP O
+the DET O
+recorded VERB O
+forced VERB B-LF
+expiratory ADJ I-LF
+volume NOUN I-LF
+in ADP I-LF
+the DET I-LF
+first ADJ I-LF
+second ADJ I-LF
+( PUNCT O
+FEV1 NOUN B-AC
+[ X O
+% NOUN O
+predicted VERB O
+] PUNCT O
+) PUNCT O
+in ADP O
+the DET O
+calendar NOUN O
+year NOUN O
+of ADP O
+sputum NOUN O
+collection NOUN O
+, PUNCT O
+the DET O
+aforementioned ADJ O
+FEV1 NOUN B-AC
+% NOUN O
+predicted VERB O
+, PUNCT O
+co NOUN O
+- PUNCT O
+pathogens NOUN O
+( PUNCT O
+Burkholderia PROPN O
+cepacia PROPN O
+complex NOUN O
+, PUNCT O
+Staphylococcus PROPN O
+aureus NOUN O
+, PUNCT O
+Achromobacter PROPN O
+and CCONJ O
+Aspergillus PROPN O
+species NOUN O
+) PUNCT O
+, PUNCT O
+maintenance NOUN O
+treatment NOUN O
+( PUNCT O
+azithromycin NOUN O
+, PUNCT O
+inhaled ADJ O
+antibiotics NOUN O
+and/or CCONJ O
+mucolytic ADJ O
+therapies NOUN O
+) PUNCT O
+, PUNCT O
+as SCONJ O
+well ADV O
+as SCONJ O
+treatment NOUN O
+episodes NOUN O
+requiring VERB O
+intravenous ADJ B-LF
+( PUNCT O
+IV PROPN B-AC
+) PUNCT O
+antibiotics NOUN O
+( PUNCT O
+number NOUN O
+of ADP O
+episodes NOUN O
+and CCONJ O
+days NOUN O
+of ADP O
+hospitalisation NOUN O
+) PUNCT O
+and CCONJ O
+the DET O
+number NOUN O
+of ADP O
+outpatient NOUN O
+visits NOUN O
+in ADP O
+the DET O
+12 NUM O
+- PUNCT O
+months NOUN O
+before ADP O
+sputum NOUN O
+collection NOUN O
+were AUX O
+recorded VERB O
+as SCONJ O
+described VERB O
+previously ADV O
+[ X O
+13 NUM O
+] PUNCT O
+. PUNCT O
+
+FEV1 PROPN B-AC
+– PUNCT O
+Forced VERB O
+Expiratory ADJ O
+Volume NOUN O
+in ADP O
+1st ADJ O
+Second NOUN O
+; PUNCT O
+FVC PROPN B-AC
+– PUNCT O
+Forced VERB B-LF
+Vital ADJ I-LF
+Capacity NOUN I-LF
+; PUNCT O
+REE PROPN B-AC
+– PUNCT O
+Resting VERB B-LF
+Energy NOUN I-LF
+Expenditure NOUN I-LF
+; PUNCT O
+Kcal NOUN O
+– PUNCT O
+Kilocalories NOUN O
+; PUNCT O
+FFM PROPN B-AC
+– PUNCT O
+Fat NOUN B-LF
+Free ADJ I-LF
+Mass. NOUN I-LF
+
+AD PROPN B-AC
+, PUNCT O
+aggregate ADJ B-LF
+data NOUN I-LF
+; PUNCT O
+HR PROPN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+IPD PROPN B-AC
+, PUNCT O
+individual ADJ B-LF
+participant NOUN I-LF
+data NOUN I-LF
+. PUNCT O
+
+ADAR1 NOUN B-AC
+, PUNCT O
+adenosine NOUN B-LF
+deaminase NOUN I-LF
+acting VERB I-LF
+on ADP I-LF
+RNA NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+ADAR1KO PROPN B-AC
+, PUNCT O
+fully ADV B-LF
+ADAR1 NOUN I-LF
+- PUNCT I-LF
+deficient ADJ I-LF
+; PUNCT O
+FL PROPN B-AC
+- PUNCT B-AC
+MAVS PROPN B-AC
+, PUNCT O
+full ADJ B-LF
+- PUNCT I-LF
+length NOUN I-LF
+MAVS PROPN I-LF
+; PUNCT O
+IFN PROPN B-AC
+, PUNCT O
+interferon NOUN B-LF
+; PUNCT O
+IRF3 NOUN B-AC
+, PUNCT O
+IFN PROPN B-LF
+regulatory ADJ I-LF
+transcription NOUN I-LF
+factor NOUN I-LF
+3 NUM I-LF
+; PUNCT O
+MAVS PROPN B-AC
+, PUNCT O
+mitochondrial ADJ B-LF
+antiviral ADJ I-LF
+signaling NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+MeV PROPN B-AC
+, PUNCT O
+measles NOUN B-LF
+virus NOUN I-LF
+; PUNCT O
+MOI PROPN B-AC
+, PUNCT O
+multiplicity NOUN B-LF
+of ADP I-LF
+infection NOUN I-LF
+; PUNCT O
+N PROPN O
+, PUNCT O
+nucleoprotein NOUN O
+; PUNCT O
+p150KO PROPN B-AC
+, PUNCT O
+selectively ADV B-LF
+ADAR1p150 NOUN I-LF
+- PUNCT I-LF
+deficient ADJ I-LF
+; PUNCT O
+pIRF3 PROPN O
+, PUNCT O
+phospho NOUN O
+- PUNCT O
+IRF3 NOUN B-AC
+; PUNCT O
+PKR NOUN B-AC
+, PUNCT O
+protein NOUN B-LF
+kinase NOUN I-LF
+R PROPN I-LF
+; PUNCT O
+pPKR PROPN O
+, PUNCT O
+phospho NOUN O
+- PUNCT O
+PKR NOUN B-AC
+; PUNCT O
+UI PROPN O
+, PUNCT O
+uninfected ADJ O
+. PUNCT O
+
+It PRON O
+would AUX O
+be AUX O
+interesting ADJ O
+to PART O
+see VERB O
+if SCONJ O
+this DET O
+low ADJ O
+intrinsic ADJ O
+DAP PROPN B-AC
+- PUNCT O
+PG NOUN B-AC
+hydrolyzing NOUN O
+activity NOUN O
+could AUX O
+be AUX O
+stimulated VERB O
+by ADP O
+another DET O
+hemolymph NOUN O
+protein(s NOUN O
+) PUNCT O
+that PRON O
+could AUX O
+associate VERB O
+with ADP O
+PGRP NOUN B-AC
+- PUNCT O
+SA PROPN O
+, PUNCT O
+such ADJ O
+as ADP O
+Gram NOUN B-LF
+- PUNCT I-LF
+negative ADJ I-LF
+bacteria NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+GNBP1 PROPN B-AC
+) PUNCT O
+( PUNCT O
+see VERB O
+below ADV O
+) PUNCT O
+. PUNCT O
+
+The DET O
+FAST PROPN O
+- PUNCT O
+MI PROPN O
+Tunisia PROPN O
+registry NOUN O
+was AUX O
+set VERB O
+up ADP O
+through ADP O
+a DET O
+close ADJ O
+collaboration NOUN O
+between ADP O
+the DET O
+Tunisian ADJ B-LF
+Society PROPN I-LF
+of ADP I-LF
+Cardiology PROPN I-LF
+and CCONJ I-LF
+Cardiovascular PROPN I-LF
+Surgery PROPN I-LF
+( PUNCT O
+TSCCS PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+French PROPN B-LF
+Society PROPN I-LF
+of ADP I-LF
+Cardiology PROPN I-LF
+( PUNCT O
+FSC PROPN B-AC
+) PUNCT O
+. PUNCT O
+Participation NOUN O
+in ADP O
+this DET O
+first ADJ O
+Tunisian ADJ O
+registry NOUN O
+was AUX O
+proposed VERB O
+to ADP O
+all DET O
+Tunisian ADJ O
+hospitals NOUN O
+( PUNCT O
+in ADP O
+both CCONJ O
+public ADJ O
+and CCONJ O
+private ADJ O
+sectors NOUN O
+) PUNCT O
+. PUNCT O
+
+As SCONJ O
+CPXV203 PROPN O
+N146 PROPN O
+is AUX O
+not PART O
+solvent NOUN O
+- PUNCT O
+accessible ADJ O
+, PUNCT O
+its PRON O
+lack NOUN O
+of ADP O
+glycosylation NOUN O
+( PUNCT O
+mass NOUN O
+spec NOUN O
+and CCONJ O
+PNGase PROPN O
+treatment NOUN O
+, PUNCT O
+unpublished ADJ O
+data NOUN O
+) PUNCT O
+is AUX O
+not PART O
+surprising ADJ O
+. PUNCT O
+( PUNCT O
+B NOUN O
+) PUNCT O
+Structure NOUN O
+- PUNCT O
+based VERB O
+alignment NOUN O
+( PUNCT O
+Dali PROPN O
+server NOUN O
+) PUNCT O
+of ADP O
+CPXV203 PROPN O
+with ADP O
+various ADJ O
+poxvirus NOUN O
+CKBPs NOUN B-AC
+: PUNCT O
+ectromelia NOUN O
+virus NOUN O
+( PUNCT O
+ECTV PROPN O
+) PUNCT O
+CrmD PROPN O
+C PROPN O
+- PUNCT O
+terminal ADJ O
+domain NOUN O
+( PUNCT O
+CrmD PROPN O
+- PUNCT O
+CTD PROPN O
+) PUNCT O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+, PUNCT O
+vaccinia NOUN O
+virus NOUN O
+( PUNCT O
+VACV PROPN O
+) PUNCT O
+A41 PROPN O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+, PUNCT O
+ECTV PROPN O
+vCCI NOUN O
+[ PUNCT O
+3 NUM O
+] PUNCT O
+, PUNCT O
+rabbitpox NOUN O
+( PUNCT O
+RPV PROPN O
+) PUNCT O
+vCCI NOUN O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+cowpox NOUN B-LF
+virus NOUN I-LF
+( PUNCT O
+CPXV PROPN B-AC
+) PUNCT O
+vCCI NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Extracted VERB B-LF
+ion NOUN I-LF
+chromatograms NOUN I-LF
+( PUNCT O
+EICs NOUN B-AC
+) PUNCT O
+were AUX O
+produced VERB O
+for ADP O
+each DET O
+standard NOUN O
+using VERB O
+the DET O
+ion NOUN O
+series NOUN O
+indicated VERB O
+in ADP O
+Table NOUN O
+A NOUN O
+in ADP O
+S2 PROPN O
+File PROPN O
+and CCONJ O
+a DET O
++ NOUN O
+/- NOUN O
+0.1 NUM O
+m NOUN B-AC
+/ SYM B-AC
+z NOUN B-AC
+tolerance NOUN O
+. PUNCT O
+
+Postpartum ADJ O
+depressive ADJ O
+symptom NOUN O
+was AUX O
+measured VERB O
+using VERB O
+the DET O
+Edinburg PROPN B-LF
+Postnatal PROPN I-LF
+Depression PROPN I-LF
+Scale PROPN I-LF
+( PUNCT O
+EPDS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+33 NUM O
+] PUNCT O
+. PUNCT O
+
+KOR PROPN B-AC
+left VERB B-LF
+, PUNCT I-LF
+KOR PROPN I-LF
+activity NOUN I-LF
+remained VERB I-LF
+; PUNCT O
+DOR PROPN B-AC
+left VERB B-LF
+, PUNCT I-LF
+DOR PROPN I-LF
+activity NOUN I-LF
+remained VERB I-LF
+; PUNCT O
+MOR PROPN B-AC
+left VERB B-LF
+, PUNCT I-LF
+MOR PROPN I-LF
+activity NOUN I-LF
+remained VERB I-LF
+. PUNCT O
+
+By ADP O
+subtracting VERB O
+the DET O
+risk NOUN O
+attributable ADJ O
+to ADP O
+main ADJ O
+effects NOUN O
+only ADV O
+from ADP O
+the DET O
+total ADJ O
+risk NOUN O
+, PUNCT O
+we PRON O
+isolated VERB O
+the DET O
+absolute ADJ B-LF
+risk NOUN I-LF
+due ADJ I-LF
+to ADP I-LF
+interaction NOUN I-LF
+( PUNCT O
+ARI NOUN B-AC
+) PUNCT O
+in ADP O
+the DET O
+additive ADJ O
+scale NOUN O
+for ADP O
+each DET O
+intersectional ADJ O
+stratum NOUN O
+. PUNCT O
+
+Serum ADJ O
+β2 NOUN O
+-microglobulin NOUN O
+levels NOUN O
+in ADP O
+Coronavirus PROPN B-LF
+Disease PROPN I-LF
+2019 NUM I-LF
+( PUNCT O
+Covid-19 PROPN B-AC
+): PUNCT O
+another DET O
+prognosticator NOUN O
+of ADP O
+disease NOUN O
+severity NOUN O
+? PUNCT O
+
+At ADP O
+the DET O
+same ADJ O
+time NOUN O
+, PUNCT O
+the DET O
+uncertainty NOUN O
+in ADP O
+these DET O
+projections NOUN O
+is AUX O
+accounted VERB O
+for ADP O
+in ADP O
+the DET O
+calculation NOUN O
+of ADP O
+standard ADJ B-LF
+errors NOUN I-LF
+( PUNCT O
+SEs NOUN B-AC
+) PUNCT O
+and CCONJ O
+test NOUN O
+statistics NOUN O
+. PUNCT O
+
+Diagnostic ADJ O
+imaging NOUN O
+studies NOUN O
+included VERB O
+chest NOUN B-LF
+radiograph NOUN I-LF
+( PUNCT O
+CR NOUN B-AC
+) PUNCT O
+and CCONJ O
+spiral ADJ O
+CT NOUN B-AC
+. PUNCT O
+
+Acute ADJ B-LF
+respiratory ADJ I-LF
+distress NOUN I-LF
+syndrome NOUN I-LF
+( PUNCT O
+ARDS PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+devastating ADJ O
+clinical ADJ O
+syndrome NOUN O
+with ADP O
+high ADJ O
+mortality NOUN O
+( PUNCT O
+about ADV O
+30%-50%)[1 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+Australian PROPN B-LF
+Trial PROPN I-LF
+in ADP I-LF
+Acute PROPN I-LF
+Hepatitis PROPN I-LF
+C PROPN I-LF
+( PUNCT O
+ATAHC PROPN B-AC
+) PUNCT O
+was AUX O
+a DET O
+prospective ADJ O
+, PUNCT O
+non ADJ O
+- ADJ O
+randomised ADJ O
+trial NOUN O
+of ADP O
+the DET O
+natural ADJ O
+history NOUN O
+and CCONJ O
+treatment NOUN O
+of ADP O
+recently ADV O
+acquired VERB O
+HCV PROPN B-AC
+infection NOUN O
+, PUNCT O
+and CCONJ O
+predominantly ADV O
+recruited VERB O
+PWID PROPN B-AC
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+as SCONJ O
+per ADP O
+the DET O
+reporting NOUN B-LF
+of ADP I-LF
+studies NOUN I-LF
+conducted VERB I-LF
+using VERB I-LF
+observational ADJ I-LF
+routinely ADV I-LF
+collected VERB I-LF
+health NOUN I-LF
+data NOUN I-LF
+statement NOUN I-LF
+for ADP I-LF
+pharmacoepidemiology NOUN I-LF
+( PUNCT O
+RECORD NOUN B-AC
+- PUNCT B-AC
+PE PROPN B-AC
+) PUNCT O
+guideline NOUN O
+( PUNCT O
+S1 PROPN O
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+
+ABOi PROPN B-AC
+, PUNCT O
+ABO PROPN B-LF
+incompatible ADJ I-LF
+; PUNCT O
+KT PROPN B-AC
+, PUNCT O
+kidney NOUN B-LF
+transplantation NOUN I-LF
+; PUNCT O
+ABOc PROPN B-AC
+, PUNCT O
+ABO PROPN B-LF
+compatible ADJ I-LF
+. PUNCT O
+
+The DET O
+galactose NOUN O
+plates NOUN O
+contained VERB O
+1 NUM O
+mg NOUN O
+/ SYM O
+l NOUN O
+of ADP O
+the DET O
+respiration NOUN O
+inhibitor NOUN O
+Antimycin PROPN B-LF
+A PROPN I-LF
+( PUNCT O
+AA PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+For ADP O
+making VERB O
+G NOUN B-LF
+- NOUN I-LF
+protein NOUN I-LF
+coupled VERB I-LF
+receptor NOUN I-LF
+( PUNCT O
+GPCR PROPN B-AC
+) PUNCT O
+transgenic ADJ O
+reporters NOUN O
+( PUNCT O
+listed VERB O
+in ADP O
+S3 PROPN O
+Table PROPN O
+) PUNCT O
+, PUNCT O
+a DET O
+PCR PROPN O
+fusion NOUN O
+approach NOUN O
+was AUX O
+used VERB O
+[ X O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+Accordingly ADV O
+, PUNCT O
+we PRON O
+need VERB O
+to PART O
+clarify VERB O
+which DET O
+risk NOUN O
+factors NOUN O
+promote VERB O
+DD PROPN B-AC
+to PART O
+establish VERB O
+preventive ADJ O
+measures NOUN O
+against ADP O
+DD PROPN B-AC
+. PUNCT O
+In ADP O
+the DET O
+present ADJ O
+study NOUN O
+, PUNCT O
+we PRON O
+focused VERB O
+on ADP O
+metabolic ADJ B-LF
+syndrome NOUN I-LF
+( PUNCT O
+MS PROPN B-AC
+) PUNCT O
+component NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+overweight NOUN B-LF
+( PUNCT O
+OW NOUN B-AC
+) PUNCT O
+, PUNCT O
+hypertension NOUN B-LF
+( PUNCT O
+HT NOUN B-AC
+) PUNCT O
+, PUNCT O
+dyslipidemia NOUN B-LF
+( PUNCT O
+DL NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+impaired ADJ B-LF
+glucose NOUN I-LF
+tolerance NOUN I-LF
+( PUNCT O
+IGT NOUN B-AC
+) PUNCT O
+, PUNCT O
+because SCONJ O
+MS PROPN B-AC
+component NOUN O
+has VERB O
+some DET O
+influence NOUN O
+on ADP O
+atherosclerosis NOUN O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+and CCONJ O
+accumulation NOUN O
+of ADP O
+MS PROPN B-AC
+component NOUN O
+increase VERB O
+the DET O
+risk NOUN O
+of ADP O
+atherosclerosis NOUN O
+events NOUN O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+Purified VERB O
+RAG NOUN O
+proteins NOUN O
+can AUX O
+, PUNCT O
+however ADV O
+, PUNCT O
+transpose VERB O
+a DET O
+DNA NOUN O
+sequence NOUN O
+flanked VERB O
+by ADP O
+two NUM O
+conserved VERB O
+sequence NOUN O
+elements NOUN O
+( PUNCT O
+recombination NOUN B-LF
+signal NOUN I-LF
+sequences NOUN I-LF
+or CCONJ O
+RSS NOUN B-AC
+) PUNCT O
+differing VERB O
+in ADP O
+length NOUN O
+( PUNCT O
+i.e. X O
+, PUNCT O
+a DET O
+12 NUM O
+- PUNCT O
+RSS NOUN B-AC
+and CCONJ O
+a DET O
+23 NUM O
+- PUNCT O
+RSS NOUN B-AC
+) PUNCT O
+into ADP O
+an DET O
+unrelated ADJ O
+DNA NOUN O
+target NOUN O
+[ X O
+5,6 NUM O
+] PUNCT O
+. PUNCT O
+
+A X O
+) PUNCT O
+grain NOUN B-LF
+yield NOUN I-LF
+per ADP O
+plant NOUN O
+( PUNCT O
+GY PROPN B-AC
+) PUNCT O
+, PUNCT O
+B X O
+) PUNCT O
+thousand NUM O
+kernel NOUN O
+weight NOUN O
+( PUNCT O
+TKW PROPN B-AC
+) PUNCT O
+, PUNCT O
+C X O
+) PUNCT O
+number NOUN B-LF
+of ADP I-LF
+kernels NOUN I-LF
+per ADP I-LF
+spike NOUN I-LF
+( PUNCT O
+NKS PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+D X O
+) PUNCT O
+number NOUN B-LF
+of ADP I-LF
+spikelets NOUN I-LF
+per ADP I-LF
+spike NOUN I-LF
+( PUNCT O
+NSS PROPN B-AC
+) PUNCT O
+. PUNCT O
+Values NOUN O
+are AUX O
+the DET O
+mean NOUN O
+± NOUN O
+SE NOUN O
+of ADP O
+four NUM O
+replicates NOUN O
+. PUNCT O
+
+EN PROPN B-AC
+: PUNCT O
+Enteral ADJ B-LF
+nutrition NOUN I-LF
+; PUNCT O
+IC PROPN O
+: PUNCT O
+Indirect ADJ O
+calorimetry NOUN O
+; PUNCT O
+ICU PROPN B-AC
+: PUNCT O
+Intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+; PUNCT O
+RRT NOUN O
+: PUNCT O
+Renal ADJ O
+replacement NOUN O
+therapy NOUN O
+; PUNCT O
+TPN NOUN B-AC
+: PUNCT O
+Total ADJ B-LF
+parenteral ADJ I-LF
+nutrition NOUN I-LF
+. PUNCT O
+
+The DET O
+Abbreviated PROPN B-LF
+Injury PROPN I-LF
+Scale PROPN I-LF
+( PUNCT O
+AIS PROPN B-AC
+) PUNCT O
+of ADP O
+body NOUN O
+regions NOUN O
+version NOUN O
+2005 NUM O
+and CCONJ O
+the DET O
+Injury PROPN B-LF
+Severity PROPN I-LF
+Score PROPN I-LF
+( PUNCT O
+ISS PROPN B-AC
+) PUNCT O
+were AUX O
+used VERB O
+as ADP O
+surrogate ADJ O
+measures NOUN O
+of ADP O
+injury NOUN O
+severity NOUN O
+. PUNCT O
+
+OD PROPN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratios NOUN I-LF
+; PUNCT O
+95%CI NOUN O
+, PUNCT O
+relative ADJ O
+95 NUM O
+% NOUN O
+confidence NOUN O
+intervals NOUN O
+
+Because SCONJ O
+each DET O
+mutant NOUN O
+was AUX O
+assayed VERB O
+at ADP O
+least ADV O
+three NUM O
+times NOUN O
+, PUNCT O
+the DET O
+hyperoxia NOUN O
+avoidance NOUN O
+index NOUN O
+could AUX O
+be AUX O
+used VERB O
+for ADP O
+standard ADJ O
+statistical ADJ O
+methods NOUN O
+such ADJ O
+as ADP O
+analysis NOUN B-LF
+of ADP I-LF
+variance NOUN I-LF
+( PUNCT O
+ANOVA NOUN B-AC
+) PUNCT O
+. PUNCT O
+In ADP O
+a DET O
+few ADJ O
+cases NOUN O
+, PUNCT O
+the DET O
+behavior NOUN O
+of ADP O
+animals NOUN O
+in ADP O
+the DET O
+gradients NOUN O
+showed VERB O
+a DET O
+significant ADJ O
+shift NOUN O
+in ADP O
+the DET O
+preferred VERB O
+oxygen NOUN O
+concentration NOUN O
+that PRON O
+was AUX O
+not PART O
+well ADV O
+described VERB O
+by ADP O
+the DET O
+hyperoxia NOUN O
+avoidance NOUN O
+index NOUN O
+, PUNCT O
+but CCONJ O
+could AUX O
+be AUX O
+described VERB O
+using VERB O
+the DET O
+median ADJ O
+preferred VERB O
+oxygen NOUN O
+concentration NOUN O
+. PUNCT O
+
+The DET O
+ratio NOUN O
+of ADP O
+percentage NOUN O
+of ADP O
+regulatory ADJ B-LF
+T PROPN I-LF
+cells NOUN I-LF
+( PUNCT O
+Treg NOUN B-AC
+) PUNCT O
+( PUNCT O
+mainly ADV O
+pTreg NOUN B-AC
+cells NOUN O
+[ PUNCT O
+17 NUM O
+] PUNCT O
+) PUNCT O
+to ADP O
+percentage NOUN O
+of ADP O
+conventional ADJ O
+T PROPN O
+( PUNCT O
+Tcon PROPN B-AC
+) PUNCT O
+cells NOUN O
+of ADP O
+Rag PROPN B-AC
+- PUNCT B-AC
+GFP PROPN B-AC
+- PUNCT B-AC
+neg PROPN B-AC
+in ADP O
+the DET O
+thymus NOUN O
+was AUX O
+decreased VERB O
+with ADP O
+age NOUN O
+( PUNCT O
+Fig PROPN O
+1D NUM O
+, PUNCT O
+left ADJ O
+panel NOUN O
+) PUNCT O
+, PUNCT O
+while SCONJ O
+the DET O
+absolute ADJ O
+cell NOUN O
+numbers NOUN O
+of ADP O
+both DET O
+Rag PROPN B-AC
+- PUNCT B-AC
+GFP PROPN B-AC
+- PUNCT B-AC
+neg PROPN B-AC
+populations NOUN O
+( PUNCT O
+Fig PROPN O
+1D NUM O
+, PUNCT O
+right ADJ O
+panel NOUN O
+) PUNCT O
+mirrored VERB O
+the DET O
+pattern NOUN O
+observed VERB O
+with ADP O
+the DET O
+Rag PROPN B-AC
+- PUNCT O
+GFP+ PROPN B-AC
+population NOUN O
+( PUNCT O
+Fig PROPN O
+1C NUM O
+, PUNCT O
+right ADJ O
+panel NOUN O
+) PUNCT O
+. PUNCT O
+
+DSS PROPN B-AC
+, PUNCT O
+dextran NOUN B-LF
+sodium NOUN I-LF
+sulfate NOUN I-LF
+; PUNCT O
+Rbpj PROPN B-AC
+, PUNCT O
+recombination NOUN B-LF
+signal NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+for ADP I-LF
+immunoglobulin NOUN I-LF
+kappa NOUN I-LF
+J NOUN I-LF
+region NOUN I-LF
+; PUNCT O
+TNBS PROPN O
+, PUNCT O
+2,4,6 NUM O
+- PUNCT O
+Trinitrobenzene NOUN O
+sulfonic ADJ O
+acid NOUN O
+. PUNCT O
+
+The DET O
+MVA PROPN O
+pathway NOUN O
+begins VERB O
+with ADP O
+condensation NOUN O
+of ADP O
+acetyl NOUN O
+- PUNCT O
+CoA PROPN O
+to ADP O
+acetoacetyl NOUN O
+- PUNCT O
+CoA PROPN O
+, PUNCT O
+which PRON O
+is AUX O
+then ADV O
+converted VERB O
+to ADP O
+isopentenyl NOUN B-LF
+diphosphate NOUN I-LF
+( PUNCT O
+IPP PROPN B-AC
+) PUNCT O
+through ADP O
+3 NUM B-LF
+- PUNCT I-LF
+hydroxy-3 NOUN I-LF
+- PUNCT I-LF
+methylglutaryl NOUN I-LF
+- PUNCT I-LF
+CoA PROPN I-LF
+( PUNCT O
+HMG PROPN B-AC
+- PUNCT B-AC
+CoA PROPN B-AC
+) PUNCT O
+and CCONJ O
+mevalonate NOUN O
+( PUNCT O
+MVA PROPN O
+) PUNCT O
+. PUNCT O
+IPP PROPN B-AC
+acts VERB O
+as ADP O
+a DET O
+precursor NOUN O
+of ADP O
+triterpenoids NOUN O
+. PUNCT O
+
+A DET O
+group NOUN O
+of ADP O
+Ashkenazi ADJ O
+Jewish ADJ O
+centenarians NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+213 NUM O
+) PUNCT O
+, PUNCT O
+their PRON O
+offspring NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+216 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+an DET O
+age NOUN O
+- PUNCT O
+matched VERB O
+Ashkenazi ADJ O
+control NOUN O
+group NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+258 NUM O
+) PUNCT O
+were AUX O
+genotyped VERB O
+for ADP O
+66 NUM O
+polymorphisms NOUN O
+in ADP O
+36 NUM O
+candidate NOUN O
+genes NOUN O
+related VERB O
+to ADP O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+( PUNCT O
+CVD NOUN B-AC
+) PUNCT O
+. PUNCT O
+These DET O
+genes NOUN O
+were AUX O
+tested VERB O
+for ADP O
+association NOUN O
+with ADP O
+serum NOUN O
+lipoprotein NOUN O
+levels NOUN O
+and CCONJ O
+particle NOUN O
+sizes NOUN O
+, PUNCT O
+apolipoprotein NOUN O
+A1 NOUN O
+, PUNCT O
+B PROPN O
+, PUNCT O
+and CCONJ O
+C-3 PROPN O
+levels NOUN O
+and CCONJ O
+with ADP O
+outcomes NOUN O
+of ADP O
+hypertension NOUN O
+, PUNCT O
+insulin NOUN O
+resistance NOUN O
+, PUNCT O
+and CCONJ O
+mortality NOUN O
+. PUNCT O
+
+Lmod PROPN B-AC
+, PUNCT O
+leiomodin PROPN B-LF
+; PUNCT O
+RCI PROPN B-AC
+, PUNCT O
+random ADJ B-LF
+coil NOUN I-LF
+index NOUN I-LF
+. PUNCT O
+
+We PRON O
+therefore ADV O
+searched VERB O
+relevant ADJ O
+ChIP PROPN B-AC
+data NOUN O
+, PUNCT O
+which PRON O
+revealed VERB O
+the DET O
+existence NOUN O
+of ADP O
+a DET O
+hotspot NOUN O
+for ADP O
+the DET O
+binding NOUN O
+of ADP O
+pluripotency NOUN O
+factors NOUN O
+, PUNCT O
+including VERB O
+Oct4 PROPN O
+, PUNCT O
+Nanog PROPN O
+, PUNCT O
+Sox2 PROPN O
+, PUNCT O
+and CCONJ O
+Klf4 PROPN O
+, PUNCT O
+in ADP O
+a DET O
+2 NUM O
+kb NOUN O
+region NOUN O
+lying VERB O
+1 NUM O
+kb NOUN O
+upstream ADV O
+of ADP O
+the DET O
+Nodal ADJ O
+transcription NOUN B-LF
+start NOUN I-LF
+site NOUN I-LF
+( PUNCT O
+TSS PROPN B-AC
+) PUNCT O
+( PUNCT O
+Figure NOUN O
+1A NOUN O
+) PUNCT O
+[ PUNCT O
+22]–[26 X O
+] PUNCT O
+. PUNCT O
+
+Reflexive ADJ O
+visual ADJ O
+responses NOUN O
+were AUX O
+assessed VERB O
+using VERB O
+an DET O
+optokinetic ADJ B-LF
+nystagmus NOUN I-LF
+( PUNCT O
+OKN PROPN B-AC
+) PUNCT O
+paradigm NOUN O
+. PUNCT O
+
+NLR PROPN B-AC
+, PUNCT O
+neutrophil NOUN B-LF
+- ADJ I-LF
+to ADP I-LF
+- ADJ I-LF
+lymphocyte NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+hs NOUN B-AC
+- ADJ B-AC
+CRP PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+sensitivity NOUN I-LF
+C NOUN I-LF
+- ADJ I-LF
+reactive NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+eGFR PROPN O
+, PUNCT O
+estimated VERB O
+glomerular ADJ O
+filtration NOUN O
+rate NOUN O
+according VERB O
+to ADP O
+the DET O
+Modification PROPN O
+of ADP O
+Diet PROPN O
+in ADP O
+Renal PROPN O
+Disease PROPN O
+equation NOUN O
+; PUNCT O
+LDL PROPN O
+, PUNCT O
+low ADJ O
+density NOUN O
+lipoprotein;HDL NOUN O
+, PUNCT O
+high ADJ O
+density NOUN O
+lipoprotein NOUN O
+; PUNCT O
+NT NOUN B-AC
+- ADJ B-AC
+proBNP PROPN B-AC
+, PUNCT O
+n NOUN O
+- ADJ O
+terminal ADJ O
+pro ADJ O
+brain NOUN O
+natriuretic ADJ O
+peptide NOUN O
+. PUNCT O
+
+DWV PROPN B-AC
+, PUNCT O
+deformed VERB B-LF
+wing NOUN I-LF
+virus NOUN I-LF
+. PUNCT O
+
+As ADP O
+such ADJ O
+, PUNCT O
+the DET O
+developing VERB O
+eye NOUN O
+acts VERB O
+as ADP O
+a DET O
+signaling VERB O
+center NOUN O
+nucleating VERB O
+anterior ADJ O
+segment NOUN O
+morphogenesis NOUN O
+, PUNCT O
+with ADP O
+paired VERB B-LF
+- PUNCT I-LF
+like ADJ I-LF
+homeodomain NOUN I-LF
+transcription NOUN I-LF
+factor NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+PITX2 PROPN B-AC
+) PUNCT O
+being AUX O
+the DET O
+potential ADJ O
+major ADJ O
+downstream ADJ O
+ATRA PROPN B-AC
+effector NOUN O
+in ADP O
+periocular ADJ O
+NCCs NOUN B-AC
+[ X O
+30,34–36 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+frequencies NOUN O
+of ADP O
+each DET O
+animal NOUN B-LF
+source NOUN I-LF
+foods NOUN I-LF
+the DET O
+women NOUN O
+ate VERB O
+within ADP O
+the DET O
+days NOUN O
+of ADP O
+a DET O
+week NOUN O
+were AUX O
+counted VERB O
+to PART O
+assess VERB O
+animal NOUN B-LF
+source NOUN I-LF
+food NOUN I-LF
+( PUNCT O
+ASF PROPN B-AC
+) PUNCT O
+consumption NOUN O
+. PUNCT O
+
+DD PROPN B-AC
+, PUNCT O
+diversity NOUN B-LF
+- PUNCT I-LF
+dependent VERB I-LF
+; PUNCT O
+MLE PROPN B-AC
+, PUNCT O
+maximum ADJ B-LF
+likelihood NOUN I-LF
+estimate NOUN I-LF
+; PUNCT O
+PGLS PROPN B-AC
+, PUNCT O
+phylogenetic ADJ B-LF
+generalized VERB I-LF
+least ADJ I-LF
+squares NOUN I-LF
+. PUNCT O
+
+Internal ADJ B-LF
+standards NOUN I-LF
+( PUNCT O
+ISTD PROPN B-AC
+) PUNCT O
+WS NOUN B-AC
+was AUX O
+prepared VERB O
+at ADP O
+2000 NUM O
+ng NOUN O
+/ SYM O
+mL NOUN O
+by ADP O
+adding VERB O
+the DET O
+required VERB O
+volumes NOUN O
+of ADP O
+three NUM O
+ISTD PROPN B-AC
+stock NOUN O
+solutions NOUN O
+, PUNCT O
+i.e. X O
+
+Finally ADV O
+, PUNCT O
+we PRON O
+also ADV O
+consider VERB O
+the DET O
+more ADV O
+canonical ADJ O
+prediction NOUN O
+that SCONJ O
+the DET O
+rTPJ PROPN B-AC
+may AUX O
+facilitate VERB O
+choice NOUN O
+of ADP O
+delayed VERB O
+rewards NOUN O
+by ADP O
+interacting VERB O
+with ADP O
+regions NOUN O
+related VERB O
+to ADP O
+impulse NOUN O
+control NOUN O
+during ADP O
+intertemporal ADJ O
+choice NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+dorsolateral ADJ B-LF
+prefrontal ADJ I-LF
+cortex NOUN I-LF
+( PUNCT O
+DLPFC PROPN B-AC
+) PUNCT O
+[ X O
+6,31 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+Sustainable PROPN O
+Development PROPN O
+Goals PROPN O
+include VERB O
+reducing VERB O
+inequalities NOUN O
+and CCONJ O
+making VERB O
+commitments NOUN O
+to ADP O
+universal ADJ B-LF
+health NOUN I-LF
+coverage NOUN I-LF
+( PUNCT O
+UHC PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+FEF25 NUM O
+- SYM O
+75 NUM O
+% NOUN O
+: PUNCT O
+forced VERB O
+expiratory ADJ O
+flow NOUN O
+at ADP O
+25–75 NUM O
+% NOUN O
+of ADP O
+FVC PROPN B-AC
+. PUNCT O
+FEV1 PROPN B-AC
+: PUNCT O
+1st ADJ B-LF
+s NOUN I-LF
+forced VERB I-LF
+expiratory ADJ I-LF
+volume NOUN I-LF
+. PUNCT O
+
+HSA PROPN B-AC
+is AUX O
+written VERB O
+out ADP O
+as ADP O
+human ADJ B-LF
+serum NOUN I-LF
+albumin NOUN I-LF
+. PUNCT O
+
+CRB-65 PROPN B-AC
+score NOUN B-AC
+, PUNCT O
+Confusion NOUN B-LF
+/ SYM I-LF
+Respiratory NOUN I-LF
+rate NOUN I-LF
+/ SYM I-LF
+Blood NOUN I-LF
+pressure NOUN I-LF
+/ SYM I-LF
+age NOUN I-LF
+≥ NUM I-LF
+65 NUM I-LF
+years NOUN I-LF
+score NOUN I-LF
+; PUNCT O
+qSOFA PROPN B-AC
+score NOUN B-AC
+, PUNCT O
+quick ADJ O
+Sequential PROPN O
+Organ PROPN O
+Failure PROPN O
+Assessment PROPN O
+score NOUN O
+; PUNCT O
+NEWS PROPN B-AC
+, PUNCT O
+National PROPN B-LF
+Early PROPN I-LF
+Warning PROPN I-LF
+Score PROPN I-LF
+
+Although SCONJ O
+imatinib PROPN O
+inhibits VERB O
+different ADJ O
+kinases NOUN O
+in ADP O
+various ADJ O
+diseases NOUN O
+( PUNCT O
+BCR NOUN O
+- PUNCT O
+ABL PROPN O
+in ADP O
+CML PROPN B-AC
+, PUNCT O
+KIT PROPN O
+or CCONJ O
+PDGFR NOUN O
+- PUNCT O
+alpha NOUN O
+in ADP O
+gastrointestinal ADJ B-LF
+stromal ADJ I-LF
+tumors NOUN I-LF
+[ PUNCT O
+GISTs PROPN B-AC
+] PUNCT O
+, PUNCT O
+and CCONJ O
+PDGFR NOUN O
+- PUNCT O
+alpha NOUN O
+in ADP O
+hypereosinophilic ADJ B-LF
+syndrome NOUN I-LF
+[ PUNCT O
+HES PROPN B-AC
+] PUNCT O
+) PUNCT O
+( PUNCT O
+reviewed VERB O
+in ADP O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+some DET O
+tumors NOUN O
+that PRON O
+become VERB O
+refractory ADJ O
+to PART O
+treatment NOUN O
+with ADP O
+imatinib PROPN O
+appear VERB O
+to PART O
+have VERB O
+analogous ADJ O
+secondary ADJ O
+mutations NOUN O
+in ADP O
+the DET O
+kinase NOUN O
+- PUNCT O
+coding VERB O
+domain NOUN O
+of ADP O
+the DET O
+genes NOUN O
+encoding VERB O
+these DET O
+three NUM O
+enzymes NOUN O
+. PUNCT O
+
+To PART O
+investigate VERB O
+the DET O
+correlation NOUN O
+between ADP O
+geographic ADJ O
+filling NOUN O
+delays NOUN O
+in ADP O
+the DET O
+choriocapillaris NOUN O
+using VERB O
+indocyanine ADJ B-LF
+green ADJ I-LF
+angiography NOUN I-LF
+( PUNCT O
+ICGA PROPN B-AC
+) PUNCT O
+images NOUN O
+and CCONJ O
+dilated VERB O
+vortex NOUN O
+veins NOUN O
+in ADP O
+central ADJ B-LF
+serous ADJ I-LF
+chorioretinopathy NOUN I-LF
+( PUNCT O
+CSC PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+IUCN PROPN B-AC
+, PUNCT O
+International PROPN B-LF
+Union PROPN I-LF
+for ADP I-LF
+Conservation PROPN I-LF
+of ADP I-LF
+Nature PROPN I-LF
+. PUNCT O
+
+Moreover ADV O
+, PUNCT O
+specific ADJ O
+African ADJ O
+trials NOUN O
+have AUX O
+indicated VERB O
+that SCONJ O
+the DET O
+use NOUN O
+of ADP O
+insecticide NOUN B-LF
+- PUNCT I-LF
+treated VERB I-LF
+nets NOUN I-LF
+( PUNCT O
+ITNs PROPN B-AC
+) PUNCT O
+or CCONJ O
+indoor ADJ O
+residual ADJ O
+spraying NOUN O
+can AUX O
+reduce VERB O
+mortality NOUN O
+of ADP O
+children NOUN O
+under ADP O
+five NUM O
+in ADP O
+Africa PROPN O
+[ PUNCT O
+6–9 NUM O
+] PUNCT O
+. PUNCT O
+
+Chronic ADJ B-LF
+low ADJ I-LF
+back NOUN I-LF
+pain NOUN I-LF
+( PUNCT O
+CLBP PROPN B-AC
+) PUNCT O
+is AUX O
+widely ADV O
+prevalent ADJ O
+, PUNCT O
+and CCONJ O
+in ADP O
+majority NOUN O
+it PRON O
+is AUX O
+nonspecific ADJ O
+( PUNCT O
+no DET O
+clear ADJ O
+etiology NOUN O
+) PUNCT O
+in ADP O
+nature NOUN O
+. PUNCT O
+
+These DET O
+results NOUN O
+were AUX O
+consistent ADJ O
+with ADP O
+the DET O
+ability NOUN O
+of ADP O
+CD5 PROPN O
+- PUNCT O
+2 NUM O
+to PART O
+inhibit VERB O
+neutrophil NOUN O
+migration NOUN O
+into ADP O
+inflamed ADJ O
+tissue NOUN O
+in ADP O
+the DET O
+MC38 PROPN O
+colon NOUN O
+carcinoma NOUN O
+, PUNCT O
+in ADP O
+which PRON O
+CD5 PROPN O
+- PUNCT O
+2 NUM O
+inhibited VERB O
+the DET O
+number NOUN O
+of ADP O
+CD11b+/granulocyte NOUN O
+( PUNCT O
+Gr)1hi NOUN B-AC
+in ADP O
+the DET O
+solid ADJ O
+tumor NOUN O
+tissue NOUN O
+. PUNCT O
+
+BMP PROPN B-AC
+, PUNCT O
+Bone PROPN B-LF
+Morphogenetic PROPN I-LF
+Protein PROPN I-LF
+; PUNCT O
+DV PROPN B-AC
+, PUNCT O
+dorsal ADJ B-LF
+– SYM I-LF
+ventral ADJ I-LF
+; PUNCT O
+scRNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+single ADJ B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+RNA NOUN I-LF
+sequencing NOUN I-LF
+. PUNCT O
+
+Natural ADJ B-LF
+killer NOUN I-LF
+( PUNCT O
+NK PROPN B-AC
+) PUNCT O
+cells NOUN O
+kill VERB O
+a DET O
+target NOUN O
+cell NOUN O
+by ADP O
+secreting VERB O
+perforin NOUN O
+into ADP O
+the DET O
+lytic ADJ O
+immunological ADJ O
+synapse NOUN O
+, PUNCT O
+a DET O
+specialized ADJ O
+interface NOUN O
+formed VERB O
+between ADP O
+the DET O
+NK PROPN B-AC
+cell NOUN O
+and CCONJ O
+its PRON O
+target NOUN O
+. PUNCT O
+
+CFU PROPN B-AC
+, PUNCT O
+colony NOUN B-LF
+- PUNCT I-LF
+forming VERB I-LF
+unit NOUN I-LF
+; PUNCT O
+KO PROPN O
+, PUNCT O
+knockout NOUN O
+; PUNCT O
+TCR PROPN B-AC
+, PUNCT O
+T NOUN B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+The DET O
+Multiple PROPN B-LF
+Sclerosis PROPN I-LF
+Impact PROPN I-LF
+Scale–29 PROPN I-LF
+( PUNCT O
+MSIS-29 PROPN B-AC
+) PUNCT O
+questionnaire NOUN O
+is AUX O
+a DET O
+PRO NOUN B-AC
+that PRON O
+assesses VERB O
+quality NOUN O
+of ADP O
+life NOUN O
+in ADP O
+people NOUN O
+with ADP O
+multiple ADJ B-LF
+sclerosis NOUN I-LF
+( PUNCT O
+MS PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+The DET O
+incidence NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+IR NOUN B-AC
+) PUNCT O
+of ADP O
+PD PROPN B-AC
+in ADP O
+the DET O
+GTZ PROPN B-AC
+- PUNCT O
+using VERB O
+group NOUN O
+( PUNCT O
+6.4 NUM O
+per ADP O
+10,000 NUM O
+patient NOUN O
+years NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X O
+CI NOUN B-AC
+] X O
+5.5–7.4 NUM O
+) PUNCT O
+was AUX O
+lower ADJ O
+than ADP O
+the DET O
+IR NOUN B-AC
+of ADP O
+PD PROPN B-AC
+in ADP O
+the DET O
+matched VERB O
+comparison NOUN O
+cohort NOUN O
+( PUNCT O
+8.8 NUM O
+per ADP O
+10,000 NUM O
+patient NOUN O
+years NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+8.1–9.6 NUM O
+) PUNCT O
+. PUNCT O
+
+SM NOUN B-AC
+, PUNCT O
+sphingomyelin NOUN B-LF
+; PUNCT O
+AA PROPN O
+, PUNCT O
+amino NOUN O
+acid NOUN O
+; PUNCT O
+CHO PROPN O
+, PUNCT O
+carbohydrate NOUN O
+; PUNCT O
+NT PROPN O
+, PUNCT O
+nucleotide NOUN O
+; PUNCT O
+CF_Vit PROPN O
+, PUNCT O
+cofactors NOUN O
+and CCONJ O
+vitamins NOUN O
+; PUNCT O
+Xeno PROPN O
+, PUNCT O
+xenobiotic NOUN O
+; PUNCT O
+FA PROPN B-AC
+, PUNCT O
+fatty ADJ B-LF
+acid NOUN I-LF
+; PUNCT O
+FDR NOUN B-AC
+, PUNCT O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+FC PROPN B-AC
+, PUNCT O
+fold NOUN B-LF
+change NOUN I-LF
+; PUNCT O
+CON PROPN B-AC
+, PUNCT O
+control NOUN B-LF
+diet NOUN I-LF
+; PUNCT O
+CPB PROPN B-AC
+, PUNCT O
+cardiac ADJ B-LF
+protection NOUN I-LF
+blend NOUN I-LF
+. PUNCT O
+
+Bypassing VERB O
+restricted ADJ O
+presentation NOUN O
+of ADP O
+conventional ADJ O
+antigens NOUN O
+which PRON O
+typically ADV O
+activate VERB O
+< NOUN O
+0.01 NUM O
+% NOUN O
+of ADP O
+T NOUN O
+cells NOUN O
+, PUNCT O
+superantigens NOUN O
+bind VERB O
+directly ADV O
+as ADP O
+intact ADJ O
+proteins NOUN O
+to PART O
+most ADJ O
+major ADJ B-LF
+histocompatibility NOUN I-LF
+class NOUN I-LF
+II PROPN I-LF
+( PUNCT O
+MHC PROPN B-AC
+- PROPN B-AC
+II PROPN B-AC
+) PUNCT O
+and CCONJ O
+T NOUN B-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+TCR PROPN B-AC
+) PUNCT O
+molecules NOUN O
+, PUNCT O
+activating VERB O
+up ADP O
+to PART O
+20 NUM O
+% NOUN O
+of ADP O
+T NOUN O
+cells NOUN O
+[ X O
+9]–[11 X O
+] PUNCT O
+. PUNCT O
+
+BU PROPN B-AC
+, PUNCT O
+Boston PROPN B-LF
+University PROPN I-LF
+; PUNCT O
+HU PROPN O
+, PUNCT O
+Harvard PROPN B-AC
+Univeristy PROPN O
+; PUNCT O
+tMRCA PROPN B-AC
+, PUNCT O
+time NOUN B-LF
+to ADP I-LF
+the DET I-LF
+most ADV I-LF
+recent ADJ I-LF
+common ADJ I-LF
+ancestor NOUN I-LF
+; PUNCT O
+UM PROPN O
+, PUNCT O
+University PROPN B-LF
+of ADP I-LF
+Massachusetts PROPN I-LF
+Amherst PROPN I-LF
+; PUNCT O
+UMass PROPN B-AC
+, PUNCT O
+University PROPN B-LF
+of ADP I-LF
+Massachusetts PROPN I-LF
+Amherst PROPN I-LF
+. PUNCT O
+
+In ADP O
+line NOUN O
+with ADP O
+this DET O
+widely ADV O
+accepted VERB O
+notion NOUN O
+, PUNCT O
+two NUM O
+independent ADJ O
+ATM PROPN B-LF
+inhibitors NOUN I-LF
+( PUNCT O
+ATMi PROPN B-AC
+) PUNCT O
+, PUNCT O
+KU-60019 PROPN B-LF
+( PUNCT O
+ATMi-1 PROPN B-AC
+) PUNCT O
+and CCONJ O
+KU-55933 NOUN B-LF
+( PUNCT O
+ATMi-2 NOUN B-AC
+) PUNCT O
+, PUNCT O
+significantly ADV O
+reduced VERB O
+DNA NOUN O
+repair NOUN O
+in ADP O
+general ADJ O
+( PUNCT O
+Fig PROPN O
+2A NOUN O
+) PUNCT O
+and CCONJ O
+HR NOUN B-AC
+( PUNCT O
+Fig PROPN O
+1F NUM O
+) PUNCT O
+. PUNCT O
+Interestingly ADV O
+, PUNCT O
+HITT PROPN B-AC
+completely ADV O
+lost VERB O
+its PRON O
+ability NOUN O
+to PART O
+regulate VERB O
+HR NOUN B-AC
+repair NOUN O
+in ADP O
+the DET O
+presence NOUN O
+of ADP O
+ATMi PROPN B-AC
+( PUNCT O
+Figs NOUN O
+1F NUM O
+and CCONJ O
+2A NOUN O
+) PUNCT O
+. PUNCT O
+ATMi PROPN B-AC
+had VERB O
+no DET O
+obvious ADJ O
+impacts NOUN O
+on ADP O
+HITT PROPN B-AC
+expression NOUN O
+levels NOUN O
+( PUNCT O
+S2A PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+LN PROPN B-AC
+hemilineage NOUN O
+produces VERB O
+LNs NOUN B-AC
+exclusively ADV O
+for ADP O
+the DET O
+AL PROPN B-AC
+, PUNCT O
+while SCONJ O
+the DET O
+PN PROPN B-AC
+hemilineage NOUN O
+generates VERB O
+not PART O
+only ADV O
+AL PROPN B-AC
+PNs NOUN B-AC
+but CCONJ O
+also ADV O
+PNs NOUN B-AC
+of ADP O
+the DET O
+antennal ADJ B-LF
+mechanosensory NOUN I-LF
+and CCONJ I-LF
+motor NOUN I-LF
+center NOUN I-LF
+( PUNCT O
+AMMC PROPN B-AC
+) PUNCT O
+and CCONJ O
+suboesophageal ADJ B-LF
+ganglion NOUN I-LF
+( PUNCT O
+SOG PROPN B-AC
+) PUNCT O
+. PUNCT O
+Furthermore ADV O
+, PUNCT O
+the DET O
+paired VERB O
+hemilineages NOUN O
+yield VERB O
+diverse ADJ O
+PNs NOUN B-AC
+and CCONJ O
+LNs NOUN B-AC
+concurrently ADV O
+but CCONJ O
+in ADP O
+distinct ADJ O
+temporal ADJ O
+patterns NOUN O
+. PUNCT O
+
+Idiopathic ADJ B-LF
+pulmonary ADJ I-LF
+fibrosis NOUN I-LF
+( PUNCT O
+IPF PROPN B-AC
+) PUNCT O
+constitutes VERB O
+the DET O
+most ADV O
+prevalent ADJ O
+type NOUN O
+of ADP O
+idiopathic ADJ B-LF
+interstitial ADJ I-LF
+pneumonia NOUN I-LF
+( PUNCT O
+IIP PROPN B-AC
+) PUNCT O
+, PUNCT O
+accounting VERB O
+for ADP O
+55 NUM O
+% NOUN O
+of ADP O
+IIP PROPN B-AC
+cases NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+ICD PROPN B-AC
+, PUNCT O
+International PROPN B-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+. PUNCT O
+
+Reported ADJ O
+Positive ADJ B-LF
+Predictive ADJ I-LF
+Values NOUN I-LF
+( PUNCT O
+PPVs NOUN B-AC
+) PUNCT O
+for ADP O
+BI PROPN O
+- PROPN O
+RADS PROPN O
+4 NUM O
+lesions NOUN O
+are AUX O
+low ADJ O
+, PUNCT O
+ranging VERB O
+from ADP O
+20–65.2 NUM O
+% NOUN O
+as SCONJ O
+assessed VERB O
+by ADP O
+histopathology NOUN O
+[ PUNCT O
+6–9 NUM O
+] PUNCT O
+. PUNCT O
+
+ACTs NOUN B-AC
+were AUX O
+purchased VERB O
+with ADP O
+support NOUN O
+from ADP O
+African PROPN O
+Development PROPN O
+Bank PROPN O
+and CCONJ O
+Global PROPN B-LF
+Fund PROPN I-LF
+to PART I-LF
+Fight VERB I-LF
+AIDS PROPN I-LF
+, PUNCT I-LF
+Tuberculosis PROPN I-LF
+and CCONJ I-LF
+Malaria PROPN I-LF
+( PUNCT O
+GFATM PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Pulse NOUN B-LF
+pressure NOUN I-LF
+( PUNCT O
+PP NOUN B-AC
+) PUNCT O
+was AUX O
+calculated VERB O
+by ADP O
+measuring VERB O
+the DET O
+difference NOUN O
+between ADP O
+SBP PROPN B-AC
+and CCONJ O
+DBP NOUN B-AC
+. PUNCT O
+
+VKAs PROPN B-AC
+carry VERB O
+a DET O
+considerable ADJ O
+risk NOUN O
+of ADP O
+adverse ADJ O
+thromboembolic ADJ O
+and CCONJ O
+bleeding NOUN O
+events NOUN O
+, PUNCT O
+particularly ADV O
+in ADP O
+the DET O
+case NOUN O
+of ADP O
+dose NOUN O
+deviations NOUN O
+when SCONJ O
+international ADJ B-LF
+normalized ADJ I-LF
+ratio NOUN I-LF
+( PUNCT O
+INR PROPN B-AC
+) PUNCT O
+values NOUN O
+are AUX O
+outside ADP O
+the DET O
+target NOUN O
+range NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+DAPI PROPN B-AC
+, PUNCT O
+4′,6 NUM B-LF
+- PUNCT I-LF
+diamidino-2 NOUN I-LF
+- PUNCT I-LF
+phenylindole NOUN I-LF
+; PUNCT O
+DIC PROPN O
+, PUNCT O
+differential ADJ O
+interference NOUN O
+contrast NOUN O
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+IDC PROPN B-AC
+, PUNCT O
+intraerythrocytic ADJ B-LF
+developmental ADJ I-LF
+cycle NOUN I-LF
+; PUNCT O
+iRBC PROPN B-AC
+, PUNCT O
+infected ADJ B-LF
+red ADJ I-LF
+blood NOUN I-LF
+cell NOUN I-LF
+. PUNCT O
+
+Treadmill NOUN O
+exercise NOUN O
+test NOUN O
+and CCONJ O
+cardiac ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+CMR PROPN B-AC
+) PUNCT O
+were AUX O
+performed VERB O
+according VERB O
+to ADP O
+initial ADJ O
+screening NOUN O
+results NOUN O
+. PUNCT O
+
+Our PRON O
+previous ADJ O
+reports NOUN O
+from ADP O
+this DET O
+program NOUN O
+have AUX O
+verified VERB O
+the DET O
+independent ADJ O
+prognostic ADJ O
+importance NOUN O
+of ADP O
+NTproBNP PROPN B-AC
+, PUNCT O
+cTnT NOUN B-AC
+- PUNCT B-AC
+hs NOUN B-AC
+, PUNCT O
+CRP NOUN B-AC
+- PUNCT B-AC
+hs NOUN B-AC
+, PUNCT O
+interleukin NOUN B-LF
+6 NUM I-LF
+( PUNCT O
+IL-6 PROPN B-AC
+) PUNCT O
+, PUNCT O
+growth NOUN B-LF
+differentiation NOUN I-LF
+factor NOUN I-LF
+15 NUM I-LF
+( PUNCT O
+GDF-15 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+lipoprotein NOUN B-LF
+associated VERB I-LF
+phospholipase NOUN I-LF
+A2 PROPN I-LF
+( PUNCT O
+Lp PROPN B-AC
+- PUNCT B-AC
+PLA2 PROPN B-AC
+) PUNCT O
+[ PUNCT O
+14–17 NUM O
+] PUNCT O
+. PUNCT O
+
+GLM PROPN B-AC
+, PUNCT O
+general ADJ B-LF
+linear ADJ I-LF
+model NOUN I-LF
+; PUNCT O
+EOG PROPN O
+, PUNCT O
+electrooculography NOUN O
+; PUNCT O
+freq NOUN O
+, PUNCT O
+frequency NOUN O
+; PUNCT O
+TF NOUN B-AC
+, PUNCT O
+time NOUN B-LF
+- PUNCT I-LF
+frequency NOUN I-LF
+. PUNCT O
+
+Pilot NOUN O
+studies NOUN O
+with ADP O
+exhaustive ADJ O
+sampling NOUN O
+, PUNCT O
+progressive ADJ O
+means NOUN O
+analysis NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+formula NOUN O
+of ADP O
+West PROPN O
+et X O
+al NOUN O
+. PUNCT O
+, PUNCT O
+[ X O
+166 NUM O
+] PUNCT O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+a PRON O
+posteriori X O
+power NOUN O
+analysis NOUN O
+, PUNCT O
+using VERB O
+data NOUN O
+from ADP O
+our PRON O
+previous ADJ O
+studies NOUN O
+of ADP O
+cell NOUN O
+and CCONJ O
+axon NOUN O
+densities NOUN O
+, PUNCT O
+or CCONJ O
+tract NOUN O
+tracing NOUN O
+of ADP O
+pathways NOUN O
+, PUNCT O
+took VERB O
+into ADP O
+consideration NOUN O
+all DET O
+known VERB O
+and CCONJ O
+estimated VERB O
+variables NOUN O
+, PUNCT O
+including VERB O
+age NOUN O
+, PUNCT O
+sex NOUN O
+, PUNCT O
+postmortem ADJ B-LF
+interval NOUN I-LF
+( PUNCT O
+PMI PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+other ADJ O
+diagnoses NOUN O
+. PUNCT O
+
+ICU PROPN B-AC
+, PUNCT O
+Intensive PROPN B-LF
+Care PROPN I-LF
+Unit PROPN I-LF
+; PUNCT O
+LSC PROPN B-AC
+, PUNCT O
+Life NOUN B-LF
+Supporting VERB I-LF
+Care PROPN I-LF
+; PUNCT O
+LSC PROPN B-AC
+- PUNCT B-AC
+L PROPN B-AC
+, PUNCT O
+Life NOUN B-LF
+Supporting VERB I-LF
+Care PROPN I-LF
+Limitation PROPN I-LF
+; PUNCT O
+SAPS PROPN B-AC
+II NUM B-AC
+, PUNCT O
+Simplified PROPN B-LF
+Acute PROPN I-LF
+Physiology PROPN I-LF
+Score PROPN I-LF
+; PUNCT O
+SOFA PROPN B-AC
+, PUNCT O
+Sequential PROPN B-LF
+Organ PROPN I-LF
+failure PROPN I-LF
+Assessment PROPN I-LF
+; PUNCT O
+LOS PROPN B-AC
+, PUNCT O
+Length PROPN B-LF
+of ADP I-LF
+stay NOUN I-LF
+; PUNCT O
+IMCU PROPN B-AC
+, PUNCT O
+Intermediate PROPN B-LF
+Care PROPN I-LF
+Unit PROPN I-LF
+. PUNCT O
+
+Dashed ADJ O
+vertical ADJ O
+red ADJ O
+lines NOUN O
+indicate VERB O
+the DET O
+age NOUN O
+at ADP O
+which PRON O
+individuals NOUN O
+with ADP O
+previously ADV O
+negative ADJ O
+FIT NOUN B-AC
+screening NOUN O
+reach VERB O
+the DET O
+detection NOUN O
+rate NOUN O
+and CCONJ O
+NNS PROPN B-AC
+of ADP O
+those PRON O
+previously ADV O
+unscreened ADJ O
+. PUNCT O
+FIT NOUN B-AC
+, PUNCT O
+fecal ADJ B-LF
+immunochemical ADJ I-LF
+test NOUN I-LF
+; PUNCT O
+NNS PROPN B-AC
+, PUNCT O
+number NOUN B-LF
+needed VERB I-LF
+to PART I-LF
+scope VERB I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+BP PROPN B-AC
+, PUNCT O
+blood NOUN B-LF
+pressure NOUN I-LF
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+relative ADJ B-LF
+risk NOUN I-LF
+. PUNCT O
+
+Recently ADV O
+, PUNCT O
+ancient ADJ O
+DNA NOUN O
+studies NOUN O
+from ADP O
+extinct ADJ O
+animal NOUN O
+specimens NOUN O
+, PUNCT O
+e.g. X O
+, PUNCT O
+the DET O
+Elephant PROPN O
+bird NOUN O
+and CCONJ O
+the DET O
+Tasmanian ADJ O
+tiger NOUN O
+have AUX O
+been AUX O
+carried VERB O
+out ADP O
+by ADP O
+high ADJ B-LF
+- PUNCT I-LF
+throughput NOUN I-LF
+, PUNCT I-LF
+“ PUNCT I-LF
+next ADJ I-LF
+- PUNCT I-LF
+generation NOUN I-LF
+” PUNCT I-LF
+DNA NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT O
+NGS PROPN B-AC
+) PUNCT O
+technologies NOUN O
+. PUNCT O
+
+At ADP O
+many ADJ O
+levels NOUN O
+of ADP O
+the DET O
+neuraxis NOUN O
+, PUNCT O
+the DET O
+dorsoventral ADJ O
+pattern NOUN O
+of ADP O
+progenitor NOUN O
+cells NOUN O
+, PUNCT O
+which PRON O
+later ADV O
+gives VERB O
+rise NOUN O
+to ADP O
+motor NOUN O
+, PUNCT O
+sensory ADJ O
+, PUNCT O
+and CCONJ O
+local ADJ O
+circuit NOUN O
+neurons NOUN O
+, PUNCT O
+is AUX O
+initiated VERB O
+by ADP O
+the DET O
+opponent NOUN O
+signaling NOUN O
+activities NOUN O
+of ADP O
+Sonic PROPN B-LF
+hedgehog NOUN I-LF
+( PUNCT O
+Shh PROPN B-AC
+) PUNCT O
+and CCONJ O
+bone NOUN O
+morphogenetic ADJ O
+proteins NOUN O
+[ PUNCT O
+2 NUM O
+, PUNCT O
+4 NUM O
+, PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Cancer NOUN O
+and CCONJ O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+( PUNCT O
+CVD NOUN B-AC
+) PUNCT O
+were AUX O
+previously ADV O
+considered VERB O
+2 NUM O
+different ADJ O
+pathologies NOUN O
+. PUNCT O
+
+Before ADP O
+hepatectomy NOUN O
+, PUNCT O
+each DET O
+patient NOUN O
+received VERB O
+ultrasonography NOUN O
+, PUNCT O
+contrast NOUN O
+- PUNCT O
+enhanced VERB O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+( PUNCT O
+MR PROPN B-AC
+) PUNCT O
+, PUNCT O
+and/or CCONJ O
+tri ADJ O
+- PUNCT O
+phase ADJ O
+contrast NOUN O
+enhanced VERB O
+helical ADJ O
+computed VERB B-LF
+tomography NOUN I-LF
+( PUNCT O
+CT PROPN B-AC
+) PUNCT O
+for ADP O
+the DET O
+diagnosis NOUN O
+of ADP O
+CHCC PROPN B-AC
+- PUNCT B-AC
+CC PROPN B-AC
+and CCONJ O
+evaluation NOUN O
+of ADP O
+the DET O
+tumor NOUN O
+. PUNCT O
+
+Polyethyleneimine NOUN B-LF
+( PUNCT O
+PEI PROPN B-AC
+) PUNCT O
+solution NOUN O
+( PUNCT O
+50 NUM O
+% NOUN O
+) PUNCT O
+, PUNCT O
+sodium NOUN O
+borate NOUN O
+, PUNCT O
+boric NOUN O
+acid NOUN O
+, PUNCT O
+and CCONJ O
+all DET O
+other ADJ O
+chemicals NOUN O
+( PUNCT O
+unless SCONJ O
+stated VERB O
+otherwise ADV O
+) PUNCT O
+are AUX O
+obtained VERB O
+from ADP O
+Sigma PROPN O
+- PUNCT O
+Aldrich PROPN O
+( PUNCT O
+Zwijndrecht PROPN O
+, PUNCT O
+The DET O
+Netherlands PROPN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+performed VERB O
+a DET O
+contemporary ADJ O
+systematic ADJ O
+review NOUN O
+of ADP O
+the DET O
+published VERB O
+literature NOUN O
+in ADP O
+accordance NOUN O
+with ADP O
+the DET O
+Preferred PROPN B-LF
+Reporting PROPN I-LF
+Items PROPN I-LF
+for ADP I-LF
+Systematic PROPN I-LF
+Reviews PROPN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PROPN I-LF
+Analyses PROPN I-LF
+( PUNCT O
+PRISMA PROPN B-AC
+) PUNCT O
+guidelines NOUN O
+( PUNCT O
+S1 PROPN O
+File PROPN O
+) PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+LGN PROPN B-AC
+, PUNCT O
+lateral ADJ B-LF
+geniculate ADJ I-LF
+nucleus NOUN I-LF
+; PUNCT O
+RF PROPN B-AC
+, PUNCT O
+receptive ADJ B-LF
+field NOUN I-LF
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+. PUNCT O
+
+Following VERB O
+phosphorylation NOUN O
+of ADP O
+the DET O
+scaffold NOUN O
+protein NOUN O
+LAT PROPN O
+by ADP O
+activated VERB O
+ZAP70 PROPN O
+, PUNCT O
+different ADJ O
+signaling NOUN O
+modules NOUN O
+including VERB O
+phospholipase NOUN B-LF
+Cγ(PLCγ NOUN I-LF
+) PUNCT O
+are AUX O
+activated VERB O
+and CCONJ O
+this PRON O
+culminates VERB O
+in ADP O
+T NOUN O
+cell NOUN O
+activation NOUN O
+[ PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+IC50 NOUN B-AC
+, PUNCT O
+half ADJ B-LF
+- PUNCT I-LF
+maximal ADJ I-LF
+inhibitory ADJ I-LF
+concentration NOUN I-LF
+; PUNCT O
+OD NOUN B-AC
+, PUNCT O
+optical ADJ B-LF
+density NOUN I-LF
+. PUNCT O
+
+Starting VERB O
+from ADP O
+the DET O
+N NOUN O
+- NOUN O
+terminus NOUN O
+, PUNCT O
+the DET O
+names NOUN O
+and CCONJ O
+in ADP O
+parenthesis NOUN O
+the DET O
+exact ADJ O
+amino NOUN O
+acid NOUN O
+sequences NOUN O
+of ADP O
+each DET O
+domain NOUN O
+are AUX O
+as SCONJ O
+follows VERB O
+: PUNCT O
+FimH PROPN O
+lectin NOUN O
+( PUNCT O
+1–158 NUM O
+) PUNCT O
+, PUNCT O
+FimH PROPN O
+pilin NOUN O
+( PUNCT O
+161–279 NUM O
+and CCONJ O
+1–12 NUM O
+of ADP O
+donated VERB O
+strand NOUN O
+by ADP O
+FimG PROPN O
+subunit NOUN O
+) PUNCT O
+, PUNCT O
+FimG PROPN O
+( PUNCT O
+16–144 NUM O
+and CCONJ O
+1–12 NUM O
+of ADP O
+donated VERB O
+strand NOUN O
+by ADP O
+FimF PROPN O
+subunit NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+FimF PROPN O
+( PUNCT O
+16–154 NUM O
+and CCONJ O
+1–12 NUM O
+of ADP O
+donated VERB O
+strand NOUN O
+by ADP O
+the DET O
+second ADJ O
+FimF PROPN O
+) PUNCT O
+. PUNCT O
+In ADP O
+this DET O
+article NOUN O
+, PUNCT O
+if SCONJ O
+not PART O
+specified VERB O
+, PUNCT O
+FimG PROPN O
+and CCONJ O
+FimF PROPN O
+always ADV O
+refer VERB O
+to ADP O
+the DET O
+domains NOUN O
+and CCONJ O
+FimH PROPN O
+to ADP O
+the DET O
+lectin NOUN B-LF
+domain NOUN I-LF
+( PUNCT O
+Ld PROPN B-AC
+) PUNCT O
+and CCONJ O
+pilin NOUN B-LF
+domain NOUN I-LF
+( PUNCT O
+Pd PROPN B-AC
+) PUNCT O
+including VERB O
+the DET O
+linker NOUN O
+chain NOUN O
+. PUNCT O
+
+Hch PROPN B-AC
+is AUX O
+defined VERB O
+to ADP O
+describe VERB O
+the DET B-LF
+maximum ADJ I-LF
+perpendicular ADJ I-LF
+distance NOUN I-LF
+from ADP I-LF
+the DET I-LF
+vertex NOUN I-LF
+of ADP I-LF
+the DET I-LF
+arc NOUN I-LF
+to ADP I-LF
+Lch PROPN I-LF
+. PUNCT O
+
+The DET O
+diagnoses NOUN O
+used VERB O
+in ADP O
+the DET O
+National PROPN O
+Health PROPN O
+Insurance PROPN O
+Research PROPN O
+Database PROPN O
+( PUNCT O
+NHIRD PROPN B-AC
+) PUNCT O
+are AUX O
+coded VERB O
+according VERB O
+to ADP O
+the DET O
+diagnostic ADJ O
+criteria NOUN O
+of ADP O
+the DET O
+International PROPN B-LF
+Classifications PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+, PUNCT I-LF
+Revision PROPN I-LF
+9 NUM I-LF
+, PUNCT I-LF
+Clinical PROPN I-LF
+Modification PROPN I-LF
+( PUNCT O
+ICD-9 PROPN B-AC
+- PUNCT B-AC
+CM PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+data NOUN O
+analysts NOUN O
+were AUX O
+staff NOUN O
+of ADP O
+Kaohsiung PROPN O
+Medical PROPN O
+Center PROPN O
+, PUNCT O
+a DET O
+site NOUN O
+of ADP O
+the DET O
+Collaboration PROPN O
+Center PROPN O
+of ADP O
+Health PROPN O
+Information PROPN O
+Application PROPN O
+, PUNCT O
+Ministry PROPN O
+of ADP O
+Health PROPN O
+and CCONJ O
+Welfare PROPN O
+. PUNCT O
+
+There PRON O
+are VERB O
+now ADV O
+several ADJ O
+classes NOUN O
+of ADP O
+ion NOUN O
+channels NOUN O
+implicated VERB O
+in ADP O
+the DET O
+eukaryotic ADJ O
+mechanotransduction NOUN O
+machinery NOUN O
+, PUNCT O
+including VERB O
+Piezo NOUN O
+1 NUM O
+and CCONJ O
+2 NUM O
+channels NOUN O
+[ PUNCT O
+11 NUM O
+] X O
+and CCONJ O
+transient ADJ B-LF
+receptor NOUN I-LF
+potential NOUN I-LF
+channels NOUN O
+, PUNCT O
+referred VERB O
+as ADP O
+TRP PROPN B-AC
+channels NOUN O
+. PUNCT O
+
+Moreover ADV O
+, PUNCT O
+detailed ADJ O
+clinical ADJ O
+data NOUN O
+of ADP O
+the DET O
+children NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+world NOUN B-LF
+health NOUN I-LF
+organization NOUN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+HIV PROPN B-AC
+disease NOUN O
+stage NOUN O
+, PUNCT O
+OI PROPN B-AC
+, PUNCT O
+type NOUN O
+of ADP O
+HAART PROPN B-AC
+and CCONJ O
+HAART PROPN B-AC
+experience NOUN O
+and CCONJ O
+duration NOUN O
+of ADP O
+HAART PROPN B-AC
+were AUX O
+collected VERB O
+by ADP O
+reviewing VERB O
+the DET O
+medical ADJ O
+record NOUN O
+of ADP O
+HIV PROPN B-AC
+infected VERB O
+children NOUN O
+. PUNCT O
+
+ML PROPN B-AC
+, PUNCT O
+maximum ADJ B-LF
+likelihood NOUN I-LF
+; PUNCT O
+MLE PROPN B-AC
+, PUNCT O
+maximum ADJ B-LF
+likelihood NOUN I-LF
+estimate NOUN I-LF
+; PUNCT O
+PGLS PROPN B-AC
+, PUNCT O
+phylogenetic ADJ B-LF
+generalized VERB I-LF
+least ADJ I-LF
+squares NOUN I-LF
+; PUNCT O
+pPC NOUN B-AC
+, PUNCT O
+phylogenetic ADJ B-LF
+principal ADJ I-LF
+component NOUN I-LF
+. PUNCT O
+
+CSF PROPN B-AC
+- PUNCT B-AC
+cNs NOUN O
+express VERB O
+the DET O
+transient ADJ O
+potential NOUN O
+receptor NOUN O
+channel NOUN O
+3 NUM O
+( PUNCT O
+Trpp3 PROPN O
+) PUNCT O
+, PUNCT O
+further ADV O
+referred VERB O
+to ADP O
+as ADP O
+Pkd2l1 PROPN B-AC
+( PUNCT O
+for ADP O
+Polycystic ADJ B-LF
+kidney NOUN I-LF
+disease-2 NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+1)[8,12,15 NUM I-LF
+] PUNCT O
+. PUNCT O
+
+This DET O
+effect NOUN O
+was AUX O
+particularly ADV O
+clear ADJ O
+with ADP O
+trimethylated VERB B-LF
+K4 NOUN I-LF
+( PUNCT O
+trimethyl NOUN B-AC
+- PUNCT B-AC
+K4 NOUN B-AC
+) PUNCT O
+H3 NOUN O
+, PUNCT O
+where SCONJ O
+appearance NOUN O
+of ADP O
+higher ADJ O
+bands NOUN O
+corresponded VERB O
+with ADP O
+complete ADJ O
+loss NOUN O
+of ADP O
+lower ADJ O
+bands NOUN O
+of ADP O
+the DET O
+ladder NOUN O
+( PUNCT O
+Figure NOUN O
+1C NUM O
+, PUNCT O
+panel NOUN O
+iii NUM O
+) PUNCT O
+. PUNCT O
+
+Importantly ADV O
+, PUNCT O
+concomitant ADJ O
+transfection NOUN O
+of ADP O
+MEFCtl PROPN O
+. PUNCT O
+cells NOUN O
+with ADP O
+an DET O
+siRNA NOUN O
+- PUNCT O
+resistant ADJ O
+, PUNCT O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT O
+WT PROPN B-AC
+) PUNCT O
+CK1δ NOUN O
+expression NOUN O
+vector NOUN O
+partially ADV O
+restored VERB O
+Chk1 PROPN B-AC
+activation NOUN O
+in ADP O
+response NOUN O
+to ADP O
+HU PROPN O
+( PUNCT O
+Fig PROPN O
+6 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+found VERB O
+both CCONJ O
+Dip2a PROPN O
+KO PROPN B-AC
+mice NOUN O
+and CCONJ O
+WT PROPN B-AC
+littermates NOUN O
+spent VERB O
+more ADJ O
+time NOUN O
+in ADP O
+the DET O
+chamber NOUN O
+with ADP O
+S1 PROPN B-AC
+( PUNCT O
+Fig PROPN O
+7H NOUN O
+and CCONJ O
+S8F PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+indicating VERB O
+an DET O
+equal ADJ O
+predilection NOUN O
+for ADP O
+S1 PROPN B-AC
+. PUNCT O
+In ADP O
+the DET O
+social ADJ O
+novelty NOUN O
+test NOUN O
+, PUNCT O
+another DET O
+unfamiliar ADJ O
+mouse NOUN O
+was AUX O
+introduced VERB O
+as ADP O
+a DET O
+novel ADJ O
+social ADJ O
+partner NOUN O
+( PUNCT O
+stranger NOUN B-LF
+2 NUM I-LF
+, PUNCT O
+S2 NOUN B-AC
+) PUNCT O
+into ADP O
+the DET O
+aforementioned ADJ O
+empty ADJ O
+cage NOUN O
+( PUNCT O
+S8 PROPN O
+G PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+FLOWERING VERB B-LF
+LOCUS PROPN I-LF
+T PROPN I-LF
+( PUNCT O
+FT PROPN B-AC
+) PUNCT O
+, PUNCT O
+widely ADV O
+conserved VERB O
+in ADP O
+angiosperms NOUN O
+, PUNCT O
+is AUX O
+a DET O
+major ADJ O
+component NOUN O
+of ADP O
+the DET O
+mobile ADJ O
+florigen NOUN O
+. PUNCT O
+
+Navigating VERB B-LF
+the DET I-LF
+healthcare NOUN I-LF
+system NOUN I-LF
+( PUNCT O
+NHS PROPN B-AC
+) PUNCT O
+( PUNCT O
+6 NUM O
+items NOUN O
+) PUNCT O
+, PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+N NOUN O
+, PUNCT O
+number NOUN O
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CI NOUN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+
+Although SCONJ O
+under ADP B-LF
+- PUNCT I-LF
+five NUM I-LF
+mortality NOUN I-LF
+rates NOUN I-LF
+( PUNCT O
+U5MR NOUN B-AC
+) PUNCT O
+and CCONJ O
+neonatal ADJ B-LF
+mortality NOUN I-LF
+rates NOUN I-LF
+( PUNCT O
+NMR NOUN B-AC
+) PUNCT O
+have AUX O
+declined VERB O
+globally ADV O
+, PUNCT O
+from ADP O
+91 NUM O
+and CCONJ O
+36 NUM O
+to ADP O
+43 NUM O
+and CCONJ O
+19 NUM O
+per ADP O
+1,000 NUM O
+live ADJ O
+births NOUN O
+between ADP O
+2000 NUM O
+and CCONJ O
+2015 NUM O
+respectively ADV O
+, PUNCT O
+the DET O
+degree NOUN O
+of ADP O
+progress NOUN O
+varies VERB O
+across ADP O
+countries NOUN O
+and CCONJ O
+regions NOUN O
+. PUNCT O
+
+Key ADJ B-LF
+Informant PROPN I-LF
+Interview PROPN I-LF
+( PUNCT O
+KII PROPN B-AC
+) PUNCT O
+Guide NOUN O
+. PUNCT O
+
+The DET O
+CFP PROPN B-AC
+and CCONJ O
+YFP PROPN B-AC
+genes NOUN O
+were AUX O
+obtained VERB O
+by ADP O
+introducing VERB O
+specific ADJ O
+mutations NOUN O
+in ADP O
+the DET O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+GFP PROPN B-AC
+) PUNCT O
+gene NOUN O
+. PUNCT O
+
+We PRON O
+performed VERB O
+1:1 NUM O
+propensity NOUN B-LF
+score NOUN I-LF
+( PUNCT O
+PS PROPN B-AC
+) PUNCT O
+matching NOUN O
+to PART O
+establish VERB O
+control NOUN O
+group NOUN O
+without ADP O
+colon NOUN O
+polyps NOUN O
+that PRON O
+mitigated VERB O
+the DET O
+confounding VERB O
+effects NOUN O
+of ADP O
+age NOUN O
+and CCONJ O
+sex NOUN O
+. PUNCT O
+
+sIgE PROPN B-AC
+, PUNCT O
+specific ADJ B-LF
+immunoglobulin NOUN I-LF
+E. NOUN I-LF
+
+Patients NOUN O
+were AUX O
+stratified VERB O
+into ADP O
+previously ADV B-LF
+known VERB I-LF
+hepatocellular ADJ I-LF
+carcinoma NOUN I-LF
+( PUNCT O
+kHCC NOUN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+141 NUM O
+) PUNCT O
+and CCONJ O
+incidental ADJ B-LF
+hepatocellular ADJ I-LF
+carcinoma NOUN I-LF
+( PUNCT O
+iHCC NOUN B-AC
+, PUNCT O
+n NOUN O
+= SYM O
+27 NUM O
+) PUNCT O
+. PUNCT O
+
+Spinal ADJ O
+extracellular ADJ B-LF
+signal NOUN I-LF
+- NOUN I-LF
+regulated VERB I-LF
+kinase NOUN I-LF
+( PUNCT O
+ERK PROPN B-AC
+) PUNCT O
+and CCONJ O
+c NOUN O
+- NOUN O
+Jun NOUN O
+N NOUN O
+- NOUN O
+terminal ADJ O
+kinase NOUN O
+phosphorylation NOUN O
+also ADV O
+peak VERB O
+in ADP O
+dorsal ADJ O
+horn NOUN O
+astrocytes NOUN O
+three NUM O
+weeks NOUN O
+after ADP O
+partial ADJ O
+sciatic ADJ O
+nerve NOUN O
+ligation NOUN O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+. PUNCT O
+
+Underlying VERB O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+ω-1 NOUN B-AC
+, PUNCT O
+omega-1 NOUN B-LF
+; PUNCT O
+BMDC PROPN B-AC
+, PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+– PUNCT I-LF
+derived VERB I-LF
+DC PROPN I-LF
+; PUNCT O
+CD4 PROPN B-AC
+, PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+4 NUM I-LF
+; PUNCT O
+IL-17A PROPN O
+, PUNCT O
+interleukin NOUN O
+17A NUM O
+; PUNCT O
+SEA PROPN B-AC
+, PUNCT O
+soluble ADJ B-LF
+egg NOUN I-LF
+antigen NOUN I-LF
+; PUNCT O
+Th17 PROPN O
+, PUNCT O
+T NOUN O
+helper NOUN O
+17 NUM O
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+GSH PROPN B-AC
+, PUNCT O
+reduced ADJ B-LF
+glutathione NOUN I-LF
+; PUNCT O
+GSX PROPN B-AC
+, PUNCT O
+glutathione NOUN B-LF
+S NOUN I-LF
+- PUNCT I-LF
+conjugate NOUN I-LF
+; PUNCT O
+HPLC PROPN B-AC
+, PUNCT O
+High PROPN B-LF
+- PUNCT I-LF
+Performance PROPN I-LF
+Liquid PROPN I-LF
+Chromatography NOUN I-LF
+; PUNCT O
+LC PROPN B-AC
+– PUNCT B-AC
+MS PROPN B-AC
+, PUNCT O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+– PUNCT I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+; PUNCT O
+met− NOUN O
+, PUNCT O
+methionine NOUN O
+- PUNCT O
+requiring VERB O
+mutant NOUN O
+; PUNCT O
+TCEP PROPN B-AC
+, PUNCT O
+tris(2 NOUN B-LF
+- PUNCT I-LF
+carboxyethyl)phosphine NOUN I-LF
+. PUNCT O
+
+Previous ADJ O
+network NOUN O
+meta ADJ O
+analyses NOUN O
+on ADP O
+hypoglycemic ADJ O
+drugs NOUN O
+were AUX O
+focused VERB O
+on ADP O
+intermediate ADJ O
+outcomes NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+glycated ADJ B-LF
+hemoglobin NOUN I-LF
+( PUNCT O
+HbA1c NOUN B-AC
+) PUNCT O
+, PUNCT O
+or CCONJ O
+did AUX O
+not PART O
+compare VERB O
+the DET O
+effect NOUN O
+of ADP O
+the DET O
+drugs NOUN O
+on ADP O
+mortality NOUN O
+or CCONJ O
+major ADJ B-LF
+adverse ADJ I-LF
+cardiovascular ADJ I-LF
+events NOUN I-LF
+( PUNCT O
+MACE PROPN B-AC
+) PUNCT O
+in ADP O
+the DET O
+absence NOUN O
+of ADP O
+data NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+reference NOUN O
+and CCONJ O
+intervention NOUN O
+TFA PROPN O
+intakes NOUN O
+and CCONJ O
+the DET O
+relative ADJ O
+risk NOUN O
+of ADP O
+IHD NOUN B-AC
+per ADP O
+% NOUN O
+E NOUN O
+of ADP O
+TFA PROPN O
+intake NOUN O
+were AUX O
+used VERB O
+to ADP O
+calculate VERB O
+the DET O
+potential ADJ B-LF
+impact NOUN I-LF
+fraction NOUN I-LF
+( PUNCT O
+PIF NOUN B-AC
+) PUNCT O
+for ADP O
+estimation NOUN O
+of ADP O
+the DET O
+proportional ADJ O
+change NOUN O
+in ADP O
+IHD NOUN B-AC
+incidence NOUN O
+due ADJ O
+to ADP O
+the DET O
+elimination NOUN O
+of ADP O
+iTFAs NOUN B-AC
+( PUNCT O
+Eq NOUN O
+( PUNCT O
+1 NUM O
+) PUNCT O
+) PUNCT O
+. PUNCT O
+
+It PRON O
+has AUX O
+been AUX O
+shown VERB O
+that SCONJ O
+HGF PROPN B-AC
+is AUX O
+expressed VERB O
+along ADP O
+this DET O
+anatomic ADJ O
+pathway NOUN O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+mice NOUN O
+with ADP O
+absence NOUN O
+of ADP O
+the DET O
+HGF PROPN B-AC
+receptor NOUN O
+c NOUN O
+- PUNCT O
+Met NOUN O
+fail VERB O
+to PART O
+form VERB O
+muscularized ADJ O
+pleuroperitoneal ADJ B-LF
+folds NOUN I-LF
+( PUNCT O
+PPFs NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+thus ADV O
+have VERB O
+amuscular ADJ O
+diaphragms NOUN O
+[ PUNCT O
+24,25 NUM O
+] PUNCT O
+. PUNCT O
+
+CI PROPN B-AC
+, PUNCT O
+competitive ADJ B-LF
+index NOUN I-LF
+. PUNCT O
+
+Prognostic ADJ O
+assessment NOUN O
+in ADP O
+patients NOUN O
+with ADP O
+hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+( PUNCT O
+HCC PROPN B-AC
+) PUNCT O
+remains VERB O
+controversial ADJ O
+. PUNCT O
+
+AMP PROPN B-AC
+, PUNCT O
+ampicillin NOUN B-LF
+; PUNCT O
+CHL PROPN B-AC
+, PUNCT O
+chloramphenicol NOUN B-LF
+; PUNCT O
+CIP PROPN B-AC
+, PUNCT O
+ciprofloxacin NOUN B-LF
+; PUNCT O
+CRO PROPN B-AC
+, PUNCT O
+ceftriaxone NOUN B-LF
+; PUNCT O
+DAP PROPN B-AC
+, PUNCT O
+daptomycin NOUN B-LF
+; PUNCT O
+DOX PROPN B-AC
+, PUNCT O
+doxycycline NOUN B-LF
+; PUNCT O
+FOF PROPN B-AC
+, PUNCT O
+fosfomycin NOUN B-LF
+; PUNCT O
+LVX PROPN O
+, PUNCT O
+levofloxacin NOUN O
+; PUNCT O
+LZD PROPN B-AC
+, PUNCT O
+linezolid NOUN B-LF
+; PUNCT O
+mut NOUN O
+, PUNCT O
+mutant NOUN O
+; PUNCT O
+NIT PROPN B-AC
+, PUNCT O
+nitrofurantoin NOUN B-LF
+; PUNCT O
+OD PROPN B-AC
+, PUNCT O
+optical ADJ B-LF
+density NOUN I-LF
+; PUNCT O
+OXA PROPN B-AC
+, PUNCT O
+oxacillin NOUN B-LF
+; PUNCT O
+RIF PROPN B-AC
+, PUNCT O
+rifampicin NOUN B-LF
+; PUNCT O
+SPT PROPN B-AC
+, PUNCT O
+spectinomycin NOUN B-LF
+; PUNCT O
+TET PROPN O
+, PUNCT O
+tetracycline NOUN O
+; PUNCT O
+TGC PROPN B-AC
+, PUNCT O
+tigecycline NOUN B-LF
+. PUNCT O
+
+OxLDL NOUN B-AC
+, PUNCT O
+oxLDL NOUN O
+/ SYM O
+HDL PROPN B-AC
+, PUNCT O
+and CCONJ O
+oxLDL NOUN O
+/ SYM O
+LDL NOUN B-AC
+correlated VERB O
+significantly ADV O
+with ADP O
+each DET O
+other ADJ O
+and CCONJ O
+with ADP O
+all DET O
+conventional ADJ O
+lipid NOUN O
+biomarkers NOUN O
+, PUNCT O
+total ADJ B-LF
+cholesterol NOUN I-LF
+( PUNCT O
+TC PROPN B-AC
+) PUNCT O
+, PUNCT O
+triglycerides NOUN B-LF
+( PUNCT O
+TG PROPN B-AC
+) PUNCT O
+, PUNCT O
+HDL PROPN B-AC
+and CCONJ O
+LDL NOUN B-AC
+( PUNCT O
+with ADP O
+the DET O
+exception NOUN O
+that SCONJ O
+oxLDL NOUN O
+/ SYM O
+LDL NOUN B-AC
+did AUX O
+not PART O
+correlate VERB O
+with ADP O
+TC PROPN B-AC
+) PUNCT O
+. PUNCT O
+HbA1c PROPN O
+was AUX O
+weakly ADV O
+correlated VERB O
+with ADP O
+TG PROPN B-AC
+and CCONJ O
+negatively ADV O
+correlated VERB O
+with ADP O
+HDL PROPN B-AC
+. PUNCT O
+CRP PROPN B-AC
+was AUX O
+also ADV O
+negatively ADV O
+correlated VERB O
+with ADP O
+HDL PROPN B-AC
+. PUNCT O
+IL6 PROPN B-AC
+was AUX O
+weakly ADV O
+correlated VERB O
+with ADP O
+TC PROPN B-AC
+and CCONJ O
+negatively ADV O
+correlated VERB O
+with ADP O
+TG PROPN B-AC
+. PUNCT O
+OxLDL NOUN B-AC
+, PUNCT O
+oxLDL NOUN O
+/ SYM O
+HDL PROPN B-AC
+and CCONJ O
+oxLDL NOUN O
+/ SYM O
+LDL NOUN B-AC
+were AUX O
+moderately ADV O
+correlated VERB O
+with ADP O
+CRP PROPN B-AC
+. PUNCT O
+OxLDL NOUN B-AC
+was AUX O
+negatively ADV O
+correlated VERB O
+with ADP O
+IL6 PROPN B-AC
+. PUNCT O
+CRP PROPN B-AC
+was AUX O
+moderately ADV O
+correlated VERB O
+with ADP O
+IL6 PROPN B-AC
+. PUNCT O
+OxLDL NOUN B-AC
+/ SYM O
+HDL PROPN B-AC
+and CCONJ O
+CRP PROPN B-AC
+were AUX O
+negatively ADV O
+correlated VERB O
+with ADP O
+age NOUN O
+. PUNCT O
+
+This DET O
+model NOUN O
+included VERB O
+the DET O
+4 NUM O
+biomarkers NOUN O
+NTproBNP PROPN B-AC
+, PUNCT O
+TIM-1 PROPN B-AC
+, PUNCT O
+osteopontin NOUN O
+, PUNCT O
+and CCONJ O
+tissue NOUN B-LF
+inhibitor NOUN I-LF
+of ADP I-LF
+metalloproteinase-1 NOUN I-LF
+( PUNCT O
+TIMP-1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+had VERB O
+a DET O
+c NOUN O
+- NOUN O
+index NOUN O
+of ADP O
+0.79 NUM O
+. PUNCT O
+
+AUC PROPN B-AC
+, PUNCT O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+; PUNCT O
+D PROPN O
+, PUNCT O
+dioptres NOUN O
+; PUNCT O
+DGC PROPN B-AC
+, PUNCT O
+Dongguan PROPN B-LF
+Guangming PROPN I-LF
+Ophthalmic PROPN I-LF
+Hospital PROPN I-LF
+; PUNCT O
+HKC PROPN B-AC
+, PUNCT O
+Xiuying PROPN B-LF
+Optometry PROPN I-LF
+Department PROPN I-LF
+in ADP I-LF
+Haikou PROPN I-LF
+City PROPN I-LF
+; PUNCT O
+HPD PROPN B-AC
+, PUNCT O
+Huangpu PROPN B-LF
+Optometry PROPN I-LF
+Department PROPN I-LF
+; PUNCT O
+HZC PROPN B-AC
+, PUNCT O
+Optometry PROPN B-LF
+Centre PROPN I-LF
+in ADP I-LF
+Huizhou PROPN I-LF
+City PROPN I-LF
+; PUNCT O
+HZD PROPN B-AC
+, PUNCT O
+Haizhu PROPN B-LF
+Optometry PROPN I-LF
+Department PROPN I-LF
+; PUNCT O
+LHD PROPN B-AC
+, PUNCT O
+Haikou PROPN B-LF
+Longhua PROPN I-LF
+Optometry PROPN I-LF
+Department PROPN I-LF
+; PUNCT O
+MAE PROPN B-AC
+, PUNCT O
+mean ADJ B-LF
+absolute ADJ I-LF
+error NOUN I-LF
+; PUNCT O
+PYD PROPN B-AC
+, PUNCT O
+Panyu PROPN B-LF
+Optometry PROPN I-LF
+Department PROPN I-LF
+. PUNCT O
+
+The DET O
+measured VERB O
+parameters NOUN O
+included VERB O
+body NOUN B-LF
+mass NOUN I-LF
+( PUNCT O
+BM PROPN B-AC
+) PUNCT O
+, PUNCT O
+fat NOUN O
+- PUNCT O
+free ADJ O
+mass NOUN O
+( PUNCT O
+FFM PROPN B-AC
+) PUNCT O
+, PUNCT O
+body NOUN B-LF
+fat NOUN I-LF
+( PUNCT O
+BF PROPN B-AC
+) PUNCT O
+, PUNCT O
+bone NOUN B-LF
+mineral NOUN I-LF
+content NOUN I-LF
+( PUNCT O
+BMC PROPN B-AC
+) PUNCT O
+, PUNCT O
+bone NOUN B-LF
+mineral NOUN I-LF
+density NOUN I-LF
+( PUNCT O
+BMD PROPN B-AC
+) PUNCT O
+. PUNCT O
+For ADP O
+the DET O
+whole ADJ O
+- PUNCT O
+body NOUN O
+analysis NOUN O
+, PUNCT O
+the DET O
+determined VERB O
+TEM PROPN B-AC
+was AUX O
+: PUNCT O
+BM PROPN B-AC
+at ADP O
+the DET O
+level NOUN O
+of ADP O
+0.12 NUM O
+kg NOUN O
+in ADP O
+females NOUN O
+and CCONJ O
+0.29 NUM O
+kg NOUN O
+in ADP O
+males NOUN O
+; PUNCT O
+BF PROPN B-AC
+0.25 NUM O
+kg NOUN O
+and CCONJ O
+0.44 NUM O
+% NOUN O
+females NOUN O
+, PUNCT O
+0.52 NUM O
+kg NOUN O
+and CCONJ O
+0.66 NUM O
+% NOUN O
+males NOUN O
+; PUNCT O
+FFM PROPN B-AC
+0.24 NUM O
+kg NOUN O
+females NOUN O
+and CCONJ O
+0.42 NUM O
+kg NOUN O
+males NOUN O
+; PUNCT O
+BMC PROPN B-AC
+0.02 NUM O
+kg NOUN O
+females NOUN O
+and CCONJ O
+males NOUN O
+; PUNCT O
+BMD PROPN B-AC
+0.01g NUM O
+/ SYM O
+cm2 NUM O
+females NOUN O
+and CCONJ O
+males NOUN O
+. PUNCT O
+
+In ADP O
+order NOUN O
+to PART O
+avoid VERB O
+exposure NOUN O
+, PUNCT O
+healthcare NOUN O
+workers NOUN O
+are AUX O
+required VERB O
+to PART O
+wear VERB O
+personal ADJ B-LF
+protective ADJ I-LF
+equipment NOUN I-LF
+( PUNCT O
+PPE PROPN B-AC
+) PUNCT O
+[ PUNCT O
+5 NUM O
+, PUNCT O
+6 NUM O
+] PUNCT O
+, PUNCT O
+of ADP O
+which PRON O
+, PUNCT O
+the DET O
+broad ADJ O
+distribution NOUN O
+and CCONJ O
+availability NOUN O
+is AUX O
+often ADV O
+a DET O
+challenge NOUN O
+especially ADV O
+before ADP O
+upcoming ADJ O
+outbreaks NOUN O
+. PUNCT O
+
+Globally ADV O
+, PUNCT O
+the DET O
+capacity NOUN O
+of ADP O
+available ADJ O
+CD4 NOUN B-AC
+instruments NOUN O
+was AUX O
+found VERB O
+to PART O
+be AUX O
+sufficient ADJ O
+to PART O
+meet VERB O
+the DET O
+demand NOUN O
+of ADP O
+all DET O
+people NOUN B-LF
+living VERB I-LF
+with ADP I-LF
+HIV PROPN I-LF
+/ SYM I-LF
+AIDS PROPN I-LF
+( PUNCT O
+PLWHA PROPN B-AC
+) PUNCT O
+, PUNCT O
+irrespective ADV O
+of ADP O
+treatment NOUN O
+status NOUN O
+; PUNCT O
+however ADV O
+, PUNCT O
+capacity NOUN O
+to PART O
+measure VERB O
+viral ADJ O
+load NOUN O
+was AUX O
+inadequate ADJ O
+to PART O
+cover VERB O
+needs NOUN O
+in ADP O
+most ADJ O
+reporting VERB O
+countries NOUN O
+. PUNCT O
+
+CI PROPN B-AC
+- PUNCT B-AC
+MPR PROPN B-AC
+, PUNCT O
+cation NOUN B-LF
+- PUNCT I-LF
+independent ADJ I-LF
+mannose NOUN I-LF
+6 NUM I-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+PX PROPN B-AC
+, PUNCT O
+phox NOUN B-LF
+- PUNCT I-LF
+homology NOUN I-LF
+; PUNCT O
+SNX PROPN B-AC
+, PUNCT O
+Sorting PROPN B-LF
+Nexin PROPN I-LF
+family NOUN I-LF
+. PUNCT O
+
+GFR PROPN B-AC
+= VERB O
+glomerular ADJ B-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+other ADJ O
+abbreviations NOUN O
+as ADP O
+in ADP O
+Table NOUN O
+2 NUM O
+. PUNCT O
+
+The DET O
+exclusion NOUN O
+criteria NOUN O
+were AUX O
+patients NOUN O
+with ADP O
+positive ADJ O
+urinalysis NOUN O
+and CCONJ O
+urine NOUN O
+culture NOUN O
+, PUNCT O
+patients NOUN O
+who PRON O
+had AUX O
+been AUX O
+exposed VERB O
+to PART O
+irradiation NOUN O
+or CCONJ O
+hormonal ADJ O
+therapy NOUN O
+in ADP O
+the DET O
+previous ADJ O
+six NUM O
+months NOUN O
+, PUNCT O
+patients NOUN O
+with ADP O
+neurological ADJ O
+diseases NOUN O
+, PUNCT O
+patients NOUN O
+using VERB O
+anticholinergic ADJ O
+drugs NOUN O
+, PUNCT O
+calcium NOUN O
+antagonists NOUN O
+, PUNCT O
+b NOUN O
+- PUNCT O
+antagonists NOUN O
+, PUNCT O
+or CCONJ O
+dopamine NOUN O
+antagonists NOUN O
+, PUNCT O
+patients NOUN O
+with ADP O
+a DET O
+grading NOUN O
+≥ ADP O
+grade NOUN O
+III NUM O
+according VERB O
+to PART O
+the DET O
+pelvic ADJ B-LF
+organ NOUN I-LF
+prolapse NOUN I-LF
+quantification NOUN I-LF
+system NOUN O
+( PUNCT O
+POP PROPN B-AC
+- PUNCT B-AC
+Q PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+those PRON O
+unable ADJ O
+to PART O
+satisfactorily ADV O
+answer VERB O
+the DET O
+questionnaires NOUN O
+and CCONJ O
+with ADP O
+severe ADJ O
+depression NOUN O
+. PUNCT O
+
+OA PROPN B-AC
+, PUNCT O
+elevated ADJ B-LF
+CO2 NOUN I-LF
+; PUNCT O
+T NOUN O
+, PUNCT O
+elevated ADJ O
+temperature NOUN O
+. PUNCT O
+
+Proliferating ADJ B-LF
+cell NOUN I-LF
+nuclear ADJ I-LF
+antigen NOUN I-LF
+( PUNCT O
+PCNA PROPN B-AC
+) PUNCT O
+was AUX O
+used VERB O
+as ADP O
+a DET O
+protein NOUN O
+loading NOUN O
+control NOUN O
+and CCONJ O
+was AUX O
+detected VERB O
+using VERB O
+a DET O
+mouse ADJ O
+monoclonal ADJ O
+antibody NOUN O
+( PUNCT O
+clone NOUN O
+PC10 PROPN O
+, PUNCT O
+Calbiochem PROPN O
+) PUNCT O
+followed VERB O
+by ADP O
+a DET O
+secondary ADJ O
+sheep NOUN O
+anti ADJ O
+- ADJ O
+mouse ADJ O
+antibody NOUN O
+conjugated VERB O
+to ADP O
+horseradish NOUN O
+peroxidase NOUN O
+. PUNCT O
+
+In ADP O
+Nayapara PROPN O
+, PUNCT O
+estimated VERB O
+seroprotection NOUN O
+among ADP O
+1- NUM O
+to PART O
+6 NUM O
+- PUNCT O
+year NOUN O
+- PUNCT O
+olds NOUN O
+was AUX O
+high ADJ O
+for ADP O
+measles NOUN O
+, PUNCT O
+rubella NOUN O
+, PUNCT O
+diphtheria NOUN O
+, PUNCT O
+and CCONJ O
+tetanus NOUN O
+( PUNCT O
+91%–98 NUM O
+% PUNCT O
+; PUNCT O
+95 NUM O
+% PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X O
+CI NOUN B-AC
+] X O
+87%–99 NUM O
+% PUNCT O
+) PUNCT O
+; PUNCT O
+children NOUN O
+> NUM O
+6 NUM O
+years NOUN O
+were AUX O
+not PART O
+assessed VERB O
+. PUNCT O
+
+FODMAP PROPN B-AC
+= PUNCT O
+Fermentable ADJ B-LF
+Oligosaccharides NOUN I-LF
+, PUNCT I-LF
+Disaccharides NOUN I-LF
+, PUNCT I-LF
+Monosaccharides NOUN I-LF
+and CCONJ I-LF
+Polyols NOUN I-LF
+; PUNCT O
+IBS PROPN B-AC
+= PUNCT O
+Irritable ADJ B-LF
+Bowel PROPN I-LF
+Syndrome PROPN I-LF
+; PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+D PROPN O
+= PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+Diarrhoeal PROPN O
+subtype NOUN O
+; PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+C PROPN O
+= PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+Constipation NOUN O
+subtype NOUN O
+; PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+M PROPN O
+/ SYM O
+A PROPN O
+= PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+Mixed PROPN O
+/ SYM O
+Alternation PROPN O
+subtype NOUN O
+; PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+U PROPN O
+= PUNCT O
+IBS PROPN B-AC
+- PUNCT O
+Unsubtyped PROPN O
+; PUNCT O
+Suppl NOUN O
+. PUNCT O
+= PUNCT O
+Supplementary ADJ O
+material NOUN O
+. PUNCT O
+
+A DET O
+total NOUN O
+of ADP O
+89 NUM O
+patients NOUN O
+with ADP O
+detectable ADJ O
+baseline NOUN O
+mutations NOUN O
+and CCONJ O
+serial ADJ O
+ctDNA PROPN B-AC
+testing NOUN O
+data NOUN O
+were AUX O
+included VERB O
+in ADP O
+the DET O
+analysis NOUN O
+. PUNCT O
+ctDNA PROPN B-AC
+, PUNCT O
+circulating VERB B-LF
+tumor NOUN I-LF
+DNA NOUN I-LF
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+HR_feature NOUN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+risk NOUN I-LF
+feature NOUN I-LF
+; PUNCT O
+nCRT PROPN B-AC
+, PUNCT O
+neoadjuvant ADJ B-LF
+chemoradiotherapy NOUN I-LF
+; PUNCT O
+RFS PROPN B-AC
+, PUNCT O
+recurrence NOUN B-LF
+- PUNCT I-LF
+free ADJ I-LF
+survival NOUN I-LF
+; PUNCT O
+95 NUM B-AC
+% NOUN B-AC
+CI NOUN B-AC
+, PUNCT O
+95 NUM B-LF
+% NOUN I-LF
+confidence NOUN I-LF
+interval NOUN I-LF
+. PUNCT O
+
+MLE PROPN B-AC
+, PUNCT O
+maximum ADJ B-LF
+likelihood NOUN I-LF
+estimate NOUN I-LF
+. PUNCT O
+
+d. X O
+Likelihood NOUN B-LF
+ratio NOUN I-LF
+statistics NOUN I-LF
+( PUNCT O
+LRS NOUN B-AC
+) PUNCT O
+were AUX O
+calculated VERB O
+using VERB O
+Map PROPN O
+Manager PROPN O
+QTXb20 PROPN O
+. PUNCT O
+
+During ADP O
+the DET O
+initiation NOUN O
+of ADP O
+autophagy NOUN O
+, PUNCT O
+several ADJ O
+other ADJ O
+key ADJ O
+modulators NOUN O
+of ADP O
+the DET O
+Becn-1 PROPN O
+- PUNCT O
+Vps34 PROPN O
+- PUNCT O
+Atg14L PROPN O
+complex NOUN O
+were AUX O
+identified VERB O
+, PUNCT O
+including VERB O
+Unc-51 PROPN B-LF
+Like ADP I-LF
+Autophagy PROPN I-LF
+Activating PROPN I-LF
+Kinase PROPN I-LF
+1 NUM I-LF
+( PUNCT O
+ULK1 PROPN B-AC
+) PUNCT O
+and CCONJ O
+Autophagy PROPN B-LF
+And CCONJ I-LF
+Beclin PROPN I-LF
+1 NUM I-LF
+Regulator PROPN I-LF
+1 NUM I-LF
+( PUNCT O
+AMBRA1 PROPN B-AC
+) PUNCT O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+Gensini PROPN B-LF
+Gavito PROPN I-LF
+Scale PROPN I-LF
+( PUNCT O
+GGS PROPN B-AC
+) PUNCT O
+is AUX O
+specifically ADV O
+validated VERB O
+in ADP O
+DRC PROPN O
+, PUNCT O
+and CCONJ O
+was AUX O
+used VERB O
+to PART O
+cross VERB O
+- VERB O
+validate VERB O
+findings NOUN O
+on ADP O
+early ADJ O
+child NOUN O
+neurodevelopment NOUN O
+, PUNCT O
+cognitive ADJ O
+ability NOUN O
+and CCONJ O
+motor NOUN O
+development NOUN O
+outcomes NOUN O
+. PUNCT O
+
+AF PROPN O
+– PUNCT O
+atrial ADJ O
+fibrillation NOUN O
+, PUNCT O
+AH PROPN B-AC
+– PUNCT O
+arterial ADJ B-LF
+hypertension NOUN I-LF
+, PUNCT O
+CHD PROPN B-AC
+– PUNCT O
+coronary ADJ B-LF
+heart NOUN I-LF
+diseases NOUN I-LF
+, PUNCT O
+CKD NOUN B-AC
+– PUNCT O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+, PUNCT O
+Hb NOUN B-AC
+– PUNCT O
+hemoglobin NOUN B-LF
+. PUNCT O
+* PUNCT O
+p<0.050 NUM O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AIC PROPN B-AC
+, PUNCT O
+Akaike PROPN B-LF
+information NOUN I-LF
+criterion NOUN I-LF
+; PUNCT O
+NB PROPN O
+, PUNCT O
+negative ADJ O
+binomial NOUN O
+; PUNCT O
+Poi PROPN O
+, PUNCT O
+Poisson PROPN O
+; PUNCT O
+rhinov NOUN O
+, PUNCT O
+rhinovirus NOUN O
+; PUNCT O
+RSV PROPN B-AC
+, PUNCT O
+respiratory ADJ B-LF
+syncytial ADJ I-LF
+virus NOUN I-LF
+; PUNCT O
+temp NOUN O
+, PUNCT O
+temperature NOUN O
+
+This DET O
+analysis NOUN O
+aimed VERB O
+to PART O
+examine VERB O
+the DET O
+association NOUN O
+between ADP O
+baseline ADJ O
+PNI PROPN B-AC
+index NOUN O
+and CCONJ O
+Overall PROPN B-LF
+Survival PROPN I-LF
+( PUNCT O
+OS PROPN B-AC
+) PUNCT O
+in ADP O
+patients NOUN O
+with ADP O
+HCC PROPN B-AC
+treated VERB O
+with ADP O
+sorafenib PROPN O
+. PUNCT O
+
+ICER PROPN B-AC
+= PUNCT O
+Incremental ADJ B-LF
+cost NOUN I-LF
+- PUNCT I-LF
+effectiveness NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+fFN PROPN B-AC
+, PUNCT O
+fetal ADJ B-LF
+fibronectin NOUN I-LF
+; PUNCT O
+NMB PROPN B-AC
+, PUNCT O
+net ADJ B-LF
+monetary ADJ I-LF
+benefit NOUN I-LF
+. PUNCT O
+
+This DET O
+experiment NOUN O
+is AUX O
+representative ADJ O
+of ADP O
+2 NUM O
+independent ADJ O
+replicates NOUN O
+. PUNCT O
+coIP PROPN B-AC
+, PUNCT O
+co NOUN B-LF
+- NOUN I-LF
+immunoprecipitation NOUN I-LF
+; PUNCT O
+IP PROPN O
+, PUNCT O
+immunoprecipitation NOUN O
+. PUNCT O
+
+The DET O
+risk NOUN O
+of ADP O
+developing VERB O
+osteoporosis NOUN O
+was AUX O
+higher ADJ O
+in ADP O
+the DET O
+early ADJ O
+H. PROPN O
+pylori PROPN O
+treatment NOUN O
+cohort NOUN O
+( PUNCT O
+hazard NOUN O
+ratio NOUN O
+[ X O
+HR NOUN O
+] X O
+= SYM O
+1.52 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X O
+CI NOUN B-AC
+] X O
+= SYM O
+1.23–1.89 NUM O
+) PUNCT O
+and CCONJ O
+late ADJ O
+H. PROPN O
+pylori PROPN O
+treatment NOUN O
+cohort NOUN O
+( PUNCT O
+HR NOUN O
+= SYM O
+1.69 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+= SYM O
+1.39–2.05 NUM O
+) PUNCT O
+, PUNCT O
+compared VERB O
+with ADP O
+the DET O
+risk NOUN O
+in ADP O
+the DET O
+control ADJ O
+cohort NOUN O
+. PUNCT O
+
+In ADP O
+our PRON O
+model NOUN O
+, PUNCT O
+V1 PROPN O
+received VERB O
+input NOUN O
+from ADP O
+lateral ADJ B-LF
+geniculate ADJ I-LF
+nucleus NOUN I-LF
+( PUNCT O
+LGN PROPN B-AC
+) PUNCT O
+relay NOUN O
+neurons NOUN O
+, PUNCT O
+here ADV O
+represented VERB O
+by ADP O
+a DET O
+direct ADJ O
+current ADJ O
+input NOUN O
+. PUNCT O
+
+PACE PROPN B-AC
+- PUNCT B-AC
+Lift NOUN B-AC
+, PUNCT O
+Pedometer NOUN B-LF
+Accelerometer NOUN I-LF
+Consultation PROPN I-LF
+Evaluation PROPN I-LF
+- PUNCT I-LF
+Lift NOUN I-LF
+; PUNCT O
+PACE PROPN B-AC
+- PUNCT B-AC
+UP PROPN B-AC
+, PUNCT O
+Pedometer NOUN B-LF
+And CCONJ I-LF
+Consultation PROPN I-LF
+Evaluation PROPN I-LF
+- PUNCT I-LF
+UP PROPN I-LF
+. PUNCT O
+
+AD PROPN B-AC
+: PUNCT O
+Aguadulce PROPN B-LF
+; PUNCT O
+LO PROPN B-AC
+: PUNCT O
+Luz PROPN O
+d’Otono PROPN O
+; PUNCT O
+RM NOUN B-AC
+: PUNCT O
+Reina PROPN B-LF
+Mora PROPN I-LF
+. PUNCT O
+
+The DET O
+majority NOUN O
+of ADP O
+patients NOUN O
+with ADP O
+NAFLD PROPN B-AC
+have VERB O
+simple ADJ O
+steatosis NOUN O
+( PUNCT O
+non ADJ B-LF
+- ADJ I-LF
+alcoholic ADJ I-LF
+fatty ADJ I-LF
+liver NOUN I-LF
+, PUNCT O
+NAFL PROPN B-AC
+) PUNCT O
+and CCONJ O
+only ADV O
+a DET O
+minority NOUN O
+have VERB O
+non ADJ B-LF
+- ADJ I-LF
+alcoholic ADJ I-LF
+steatohepatitis NOUN I-LF
+( PUNCT O
+NASH PROPN B-AC
+) PUNCT O
+, PUNCT O
+with ADP O
+or CCONJ O
+without ADP O
+fibrosis NOUN O
+. PUNCT O
+
+To PART O
+satisfy VERB O
+all DET O
+these DET O
+requirements NOUN O
+while SCONJ O
+maintaining VERB O
+high ADJ O
+scan NOUN O
+time NOUN O
+efficiency NOUN O
+, PUNCT O
+signal NOUN B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+noise NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+SNR NOUN B-AC
+) PUNCT O
+and CCONJ O
+spatial ADJ O
+resolution NOUN O
+often ADV O
+need VERB O
+to PART O
+be AUX O
+compromised VERB O
+when SCONJ O
+imaging VERB O
+on ADP O
+1.5 NUM O
+and CCONJ O
+3 NUM O
+T PROPN O
+scanners NOUN O
+. PUNCT O
+
+Changes NOUN O
+in ADP O
+renal ADJ O
+haemodynamics NOUN O
+are AUX O
+believed VERB O
+to ADP O
+be AUX O
+primarily ADV O
+related VERB O
+to ADP O
+the DET O
+increased ADJ O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+eGFR NOUN B-AC
+) PUNCT O
+towards ADP O
+the DET O
+hyperfiltration NOUN O
+state NOUN O
+in ADP O
+addition NOUN O
+to ADP O
+a DET O
+presence NOUN O
+of ADP O
+increased ADJ O
+filtration NOUN O
+fraction NOUN O
+[ PUNCT O
+39,40 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+larvae NOUN O
+have VERB O
+fluorescent ADJ O
+macrophages NOUN O
+( PUNCT O
+red ADJ O
+) PUNCT O
+and CCONJ O
+were AUX O
+injected VERB O
+with ADP O
+fluorescent ADJ O
+S. PROPN O
+aureus PROPN O
+( PUNCT O
+green ADJ O
+) PUNCT O
+and/or CCONJ O
+fluorescently ADV O
+labelled VERB O
+M. PROPN O
+luteus PROPN O
+PGN PROPN B-AC
+( PUNCT O
+blue ADJ O
+) PUNCT O
+G NOUN O
+- NOUN O
+I NOUN O
+Images NOUN O
+of ADP O
+infected ADJ O
+larvae NOUN O
+at ADP O
+2 NUM O
+hpi NOUN B-AC
+showing VERB O
+macrophages NOUN O
+containing VERB O
+S. PROPN O
+aureus PROPN O
+, PUNCT O
+scale NOUN O
+6.9 NUM O
+μm NOUN O
+, PUNCT O
+greyscale NOUN O
+insets NOUN O
+depict VERB O
+location NOUN O
+of ADP O
+fluorescence NOUN O
+signal NOUN O
+within ADP O
+the DET O
+hatched VERB O
+box NOUN O
+of ADP O
+the DET O
+main ADJ O
+image NOUN O
+, PUNCT O
+for ADP O
+ease NOUN O
+of ADP O
+visualisation NOUN O
+( PUNCT O
+G NOUN O
+) PUNCT O
+, PUNCT O
+M. PROPN O
+luteus PROPN O
+peptidoglycan NOUN B-LF
+scale NOUN O
+6.9 NUM O
+μm NOUN O
+( PUNCT O
+H NOUN O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+both PRON O
+scale NOUN O
+10 NUM O
+μm NOUN O
+( PUNCT O
+I NOUN O
+) PUNCT O
+, PUNCT O
+J PROPN O
+Area NOUN O
+of ADP O
+macrophage NOUN O
+taken VERB O
+up ADP O
+by ADP O
+S. PROPN O
+aureus PROPN O
+at ADP O
+2 NUM O
+hpi NOUN B-AC
+( PUNCT O
+n NOUN O
+= SYM O
+3 NUM O
+, PUNCT O
+14–21 NUM O
+larvae NOUN O
+per ADP O
+group NOUN O
+, PUNCT O
+unpaired ADJ O
+t NOUN O
+- NOUN O
+test NOUN O
+) PUNCT O
+K NOUN O
+Area NOUN O
+of ADP O
+macrophage NOUN O
+taken VERB O
+up ADP O
+by ADP O
+M. PROPN O
+luteus PROPN O
+PGN PROPN B-AC
+at ADP O
+2hpi NUM O
+( PUNCT O
+n NOUN O
+= SYM O
+3 NUM O
+, PUNCT O
+11–21 NUM O
+larvae NOUN O
+per ADP O
+group NOUN O
+, PUNCT O
+two NUM O
+- NOUN O
+tailed ADJ O
+unpaired ADJ O
+t NOUN O
+- NOUN O
+test NOUN O
+, PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+p<0.0004 NUM O
+) PUNCT O
+. PUNCT O
+
+There PRON O
+were VERB O
+increases NOUN O
+in ADP O
+both CCONJ O
+lower ADJ O
+and CCONJ O
+upper ADJ O
+normal ADJ O
+limits NOUN O
+for ADP O
+blood NOUN O
+neutrophil NOUN O
+, PUNCT O
+thyroid NOUN O
+profile NOUN O
+( PUNCT O
+triiodothyronine NOUN B-LF
+( PUNCT O
+T3 NOUN B-AC
+) PUNCT O
+and CCONJ O
+thyroxine NOUN B-LF
+( PUNCT O
+T4 NOUN B-AC
+) PUNCT O
+) PUNCT O
+, PUNCT O
+testosterone NOUN O
+, PUNCT O
+estradiol NOUN O
+, PUNCT O
+and CCONJ O
+progesterone NOUN O
+and CCONJ O
+decreases NOUN O
+for ADP O
+RBC NOUN B-AC
+, PUNCT O
+hemoglobin NOUN O
+( PUNCT O
+Hb NOUN O
+) PUNCT O
+, PUNCT O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+ALT NOUN B-AC
+) PUNCT O
+and CCONJ O
+creatinine NOUN B-LF
+( PUNCT O
+Cr NOUN B-AC
+) PUNCT O
+during ADP O
+their PRON O
+third ADJ O
+trimesters NOUN O
+. PUNCT O
+
+High ADJ O
+- NOUN O
+molecular ADJ O
+- NOUN O
+weight NOUN O
+PLA PROPN B-AC
+is AUX O
+mainly ADV O
+synthesized VERB O
+through ADP O
+the DET O
+ring NOUN B-LF
+- NOUN I-LF
+opening VERB I-LF
+polymerization NOUN I-LF
+( PUNCT O
+ROP NOUN B-AC
+) PUNCT O
+of ADP O
+D PROPN O
+, PUNCT O
+L NOUN O
+- NOUN O
+lactide NOUN O
+or CCONJ O
+L NOUN O
+- NOUN O
+lactide NOUN O
+catalyzed VERB O
+by ADP O
+coordination NOUN O
+compounds NOUN O
+[ X O
+1–4 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+automated VERB O
+annotation NOUN O
+programs NOUN O
+failed VERB O
+to PART O
+identify VERB O
+VRI PROPN B-AC
+, PUNCT O
+PDP1 PROPN B-AC
+and CCONJ O
+PER PROPN B-AC
+among ADP O
+the DET O
+L. PROPN O
+madurae PROPN O
+transcripts NOUN B-LF
+with ADP I-LF
+coding VERB I-LF
+regions NOUN I-LF
+( PUNCT O
+CDS PROPN B-AC
+) PUNCT O
+. PUNCT O
+These DET O
+results NOUN O
+underscore VERB O
+the DET O
+value NOUN O
+of ADP O
+targeted VERB O
+gene NOUN O
+discovery NOUN O
+in ADP O
+combination NOUN O
+with ADP O
+the DET O
+automated VERB O
+bioinformatics NOUN O
+tools NOUN O
+to PART O
+obtain VERB O
+a DET O
+complete ADJ O
+annotation NOUN O
+for ADP O
+a DET O
+de X O
+novo X O
+transcriptome NOUN O
+. PUNCT O
+
+Central ADJ B-LF
+nervous ADJ I-LF
+system NOUN I-LF
+( PUNCT O
+CNS PROPN B-AC
+) PUNCT O
+and CCONJ O
+urinary ADJ O
+tract NOUN O
+abnormalities NOUN O
+are AUX O
+common ADJ O
+human ADJ O
+malformations NOUN O
+, PUNCT O
+but CCONJ O
+their PRON O
+variability NOUN O
+and CCONJ O
+genetic ADJ O
+complexity NOUN O
+make VERB O
+it PRON O
+difficult ADJ O
+to PART O
+identify VERB O
+the DET O
+responsible ADJ O
+genes NOUN O
+. PUNCT O
+
+Human ADJ B-LF
+endogenous ADJ I-LF
+retroviruses NOUN I-LF
+( PUNCT O
+HERVs NOUN B-AC
+) PUNCT O
+are AUX O
+remnants NOUN O
+of ADP O
+ancient ADJ O
+infectious ADJ O
+agents NOUN O
+that PRON O
+have AUX O
+integrated VERB O
+into ADP O
+the DET O
+human ADJ O
+genome NOUN O
+. PUNCT O
+
+The DET O
+in ADP O
+vitro X O
+study NOUN O
+was AUX O
+conducted VERB O
+in ADP O
+a DET O
+2 NUM O
+( PUNCT O
+infection NOUN O
+status NOUN O
+; PUNCT O
+non ADJ O
+- ADJ O
+infected ADJ B-LF
+versus ADP O
+infected ADJ B-LF
+) PUNCT O
+× SYM O
+3 NUM O
+( PUNCT O
+diets NOUN O
+; PUNCT O
+control NOUN O
+, PUNCT O
+Mix1 NOUN B-AC
+and CCONJ O
+Mix2 NOUN B-AC
+) PUNCT O
+factorial ADJ O
+design NOUN O
+. PUNCT O
+
+The DET O
+raw ADJ O
+images NOUN O
+for ADP O
+D PROPN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Raw PROPN O
+Images PROPN O
+. PUNCT O
+dpi NOUN B-AC
+, PUNCT O
+days NOUN B-LF
+post NOUN I-LF
+- PUNCT I-LF
+infection NOUN I-LF
+; PUNCT O
+ORF NOUN B-AC
+, PUNCT O
+open ADJ B-LF
+reading NOUN I-LF
+frame NOUN I-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+, PUNCT O
+reverse ADJ B-LF
+transcription NOUN I-LF
+PCR NOUN I-LF
+; PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+, PUNCT O
+Severe PROPN B-LF
+Acute PROPN I-LF
+Respiratory PROPN I-LF
+Syndrome PROPN I-LF
+Coronavirus PROPN I-LF
+2 NUM I-LF
+; PUNCT O
+scRNA NOUN O
+- PUNCT O
+seq NOUN O
+, PUNCT O
+single ADJ O
+- PUNCT O
+cell NOUN O
+RNA NOUN O
+sequencing NOUN O
+; PUNCT O
+sgRNA NOUN B-AC
+, PUNCT O
+subgenomic ADJ B-LF
+RNA NOUN I-LF
+. PUNCT O
+
+Bacteria NOUN O
+contain VERB O
+eight NUM O
+lineages NOUN O
+of ADP O
+mobile ADJ O
+group NOUN O
+II NUM O
+introns NOUN O
+, PUNCT O
+which PRON O
+are AUX O
+distinguished VERB O
+by ADP O
+different ADJ O
+IEP PROPN B-AC
+types NOUN O
+( PUNCT O
+bacterial ADJ O
+A NOUN O
+– SYM O
+F PROPN O
+, PUNCT O
+mitochondrial ADJ B-LF
+- PUNCT I-LF
+like ADJ I-LF
+( PUNCT O
+ML PROPN B-AC
+) PUNCT O
+and CCONJ O
+chloroplast NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+( PUNCT O
+CL NOUN B-AC
+) PUNCT O
+) PUNCT O
+and CCONJ O
+distinct ADJ O
+RNA NOUN O
+structural ADJ O
+subgroups NOUN O
+( PUNCT O
+IIA PROPN O
+( PUNCT O
+ML PROPN B-AC
+) PUNCT O
+, PUNCT O
+IIB PROPN O
+( PUNCT O
+CL NOUN B-AC
+and CCONJ O
+bacterial ADJ O
+lineages NOUN O
+A NOUN O
+, PUNCT O
+B PROPN O
+, PUNCT O
+and CCONJ O
+D PROPN O
+– SYM O
+F PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+IIC PROPN O
+( PUNCT O
+bacterial ADJ O
+lineage NOUN O
+C NOUN O
+) PUNCT O
+) PUNCT O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+; PUNCT O
+YFP PROPN B-AC
+, PUNCT O
+yellow ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+ANC PROPN B-AC
+, PUNCT O
+antenatal ADJ B-LF
+care NOUN I-LF
+. PUNCT O
+
+Jumonji PROPN B-LF
+domain NOUN I-LF
+- PUNCT I-LF
+containing VERB I-LF
+6 NUM I-LF
+( PUNCT O
+JMJD6 PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+member NOUN O
+of ADP O
+the DET O
+Jumonji PROPN O
+C PROPN O
+domain NOUN O
+- PUNCT O
+containing VERB O
+family NOUN O
+of ADP O
+proteins NOUN O
+. PUNCT O
+
+HOMA PROPN B-AC
+- PUNCT B-AC
+IR PROPN B-AC
+, PUNCT O
+homeostasis NOUN B-LF
+model NOUN I-LF
+assessment NOUN I-LF
+of ADP I-LF
+insulin NOUN I-LF
+resistance NOUN I-LF
+. PUNCT O
+
+CRLM NOUN O
+: PUNCT O
+colorectal ADJ O
+liver NOUN O
+metastases NOUN O
+; PUNCT O
+iCCA NOUN B-AC
+: PUNCT O
+intrahepatic ADJ B-LF
+cholangiocarcinoma NOUN I-LF
+; PUNCT O
+pCCA NOUN B-AC
+: PUNCT O
+perihilar ADJ B-LF
+cholangiocarcinoma NOUN I-LF
+; PUNCT O
+HCC NOUN B-AC
+: PUNCT O
+hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+. PUNCT O
+
+Intravoxel NOUN B-LF
+incoherent ADJ I-LF
+motion NOUN I-LF
+( PUNCT O
+IVIM PROPN B-AC
+) PUNCT O
+imaging NOUN O
+concurrently ADV O
+measures VERB O
+diffusion NOUN O
+and CCONJ O
+perfusion NOUN O
+parameters NOUN O
+and CCONJ O
+has VERB O
+potential ADJ O
+applications NOUN O
+for ADP O
+brain NOUN O
+tumor NOUN O
+classification NOUN O
+. PUNCT O
+
+We PRON O
+also ADV O
+used VERB O
+multivariable ADJ B-LF
+MR NOUN I-LF
+( PUNCT O
+MVMR PROPN B-AC
+) PUNCT O
+as ADP O
+a DET O
+sensitivity NOUN O
+analysis NOUN O
+to PART O
+adjust VERB O
+for ADP O
+C NOUN B-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+CRP PROPN B-AC
+) PUNCT O
+, PUNCT O
+an DET O
+archetypal ADJ O
+inflammatory ADJ O
+marker NOUN O
+, PUNCT O
+as ADP O
+a DET O
+general ADJ O
+downstream ADJ O
+marker NOUN O
+of ADP O
+systemic ADJ O
+inflammation NOUN O
+. PUNCT O
+
+The DET O
+zoonotic ADJ O
+coronavirus NOUN O
+Severe PROPN B-LF
+Acute PROPN I-LF
+Respiratory PROPN I-LF
+Syndrome PROPN I-LF
+Coronavirus PROPN I-LF
+2 NUM I-LF
+( PUNCT O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+) PUNCT O
+first ADV O
+emerged VERB O
+in ADP O
+Wuhan PROPN O
+, PUNCT O
+Hubei PROPN O
+Province PROPN O
+, PUNCT O
+China PROPN O
+, PUNCT O
+in ADP O
+December PROPN O
+2019 NUM O
+and CCONJ O
+was AUX O
+soon ADV O
+recognized VERB O
+as ADP O
+the DET O
+etiological ADJ O
+agent NOUN O
+of ADP O
+Coronavirus PROPN B-LF
+Disease PROPN I-LF
+2019 NUM I-LF
+( PUNCT O
+COVID-19 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+IVW PROPN O
+, PUNCT O
+inverse NOUN O
+- PUNCT O
+variance NOUN O
+weighted VERB O
+; PUNCT O
+MR PROPN B-AC
+, PUNCT O
+Mendelian ADJ B-LF
+randomization NOUN I-LF
+; PUNCT O
+OR PROPN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+The DET O
+following VERB O
+formula NOUN O
+was AUX O
+used VERB O
+to ADP O
+obtain VERB O
+an DET O
+approximate ADJ O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+) PUNCT O
+of ADP O
+the DET O
+effect NOUN O
+of ADP O
+BMI PROPN B-AC
+on ADP O
+psoriasis NOUN O
+, PUNCT O
+as SCONJ O
+previously ADV O
+demonstrated VERB O
+by ADP O
+Perry PROPN O
+and CCONJ O
+colleagues NOUN O
+[ X O
+17 NUM O
+] X O
+: PUNCT O
+OR NOUN B-AC
+= SYM O
+exp(1.81×[SD×SMD NOUN B-AC
+] X O
+) PUNCT O
+such ADJ O
+that SCONJ O
+SD NOUN B-AC
+is AUX O
+the DET O
+standard ADJ B-LF
+deviation NOUN I-LF
+increase NOUN O
+in ADP O
+BMI PROPN B-AC
+per ADP O
+SD NOUN B-AC
+change NOUN O
+in ADP O
+the DET O
+BMI PROPN B-AC
+genetic ADJ O
+instrument NOUN O
+( PUNCT O
+genetic ADJ B-LF
+risk NOUN I-LF
+score NOUN I-LF
+[ X O
+GRS PROPN B-AC
+] X O
+) PUNCT O
+, PUNCT O
+SMD NOUN B-AC
+is AUX O
+the DET O
+standardized ADJ B-LF
+mean ADJ I-LF
+difference NOUN I-LF
+, PUNCT O
+and CCONJ O
+1.81 NUM O
+is AUX O
+the DET O
+scaling VERB O
+factor NOUN O
+used VERB O
+to ADP O
+convert VERB O
+SMDs NOUN B-AC
+to ADP O
+ln(ORs NOUN B-AC
+) PUNCT O
+[ X O
+18,19 X O
+] X O
+( PUNCT O
+S1 PROPN O
+Appendix NOUN O
+Supporting NOUN O
+Text PROPN O
+A NOUN O
+) PUNCT O
+. PUNCT O
+
+Top NOUN B-LF
+of ADP I-LF
+SF NOUN I-LF
+or CCONJ I-LF
+AS NOUN I-LF
+
+To PART O
+determine VERB O
+the DET O
+precise ADJ O
+identity NOUN O
+of ADP O
+X1 NOUN O
+fraction NOUN O
+, PUNCT O
+we PRON O
+executed VERB O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+( PUNCT O
+MS PROPN B-AC
+) PUNCT O
+analysis NOUN O
+, PUNCT O
+which PRON O
+revealed VERB O
+certain ADJ O
+PEtn PROPN B-AC
+- PUNCT B-AC
+Cer PROPN B-AC
+and CCONJ O
+PtdSer PROPN B-AC
+species NOUN O
+, PUNCT O
+as SCONJ O
+expected VERB O
+( PUNCT O
+Fig PROPN O
+1B NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+most ADV O
+prominent ADJ O
+peak NOUN O
+in ADP O
+this DET O
+fraction NOUN O
+with ADP O
+an DET O
+m NOUN O
+/ SYM O
+z NOUN O
+of ADP O
+850.5 NUM O
+, PUNCT O
+however ADV O
+, PUNCT O
+did AUX O
+not PART O
+correspond VERB O
+to ADP O
+a DET O
+PEtn PROPN B-AC
+- PUNCT B-AC
+Cer PROPN B-AC
+or CCONJ O
+PtdSer PROPN B-AC
+species NOUN O
+. PUNCT O
+
+Accordingly ADV O
+, PUNCT O
+step NOUN B-LF
+width NOUN I-LF
+variability NOUN I-LF
+( PUNCT O
+SWV PROPN B-AC
+) PUNCT O
+and CCONJ O
+step NOUN B-LF
+length NOUN I-LF
+variability NOUN I-LF
+( PUNCT O
+SLV NOUN B-AC
+) PUNCT O
+are AUX O
+generally ADV O
+considered VERB O
+markers NOUN O
+of ADP O
+reduced VERB O
+walking NOUN O
+balance NOUN O
+integrity NOUN O
+. PUNCT O
+
+The DET O
+coronavirus NOUN B-LF
+disease NOUN I-LF
+2019 NUM I-LF
+( PUNCT O
+COVID-19 NOUN B-AC
+) PUNCT O
+has AUX O
+become VERB O
+a DET O
+worst ADJ O
+pandemic NOUN O
+. PUNCT O
+
+Water NOUN O
+vapor NOUN O
+prevents VERB O
+temperature NOUN O
+from ADP O
+increasing VERB O
+with ADP O
+VOCs NOUN B-AC
+adsorption NOUN O
+equilibria NOUN O
+; PUNCT O
+when SCONJ O
+the DET O
+relative ADJ B-LF
+humidity NOUN I-LF
+( PUNCT O
+RH NOUN B-AC
+) PUNCT O
+increases NOUN O
+, PUNCT O
+the DET O
+adsorption NOUN O
+of ADP O
+VOCs NOUN B-AC
+by ADP O
+building NOUN O
+materials NOUN O
+decreases VERB O
+, PUNCT O
+but CCONJ O
+it PRON O
+increases NOUN O
+with ADP O
+polarity NOUN O
+increases NOUN O
+in ADP O
+VOC NOUN O
+molecules NOUN O
+[ X O
+6,7 NUM O
+] PUNCT O
+. PUNCT O
+
+SDFR PROPN B-AC
+rates NOUN O
+increased VERB O
+after ADP O
+introduction NOUN O
+of ADP O
+treat NOUN O
+- PUNCT O
+to PART O
+- PUNCT O
+target NOUN O
+( PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+[ PUNCT O
+HR PROPN B-AC
+] PUNCT O
+2006–2010 NUM O
+relative ADJ O
+to PART O
+1993–1996 NUM O
+: PUNCT O
+3.35 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.46 NUM O
+to PART O
+7.72 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.004 NUM O
+] PUNCT O
+; PUNCT O
+HR PROPN B-AC
+2011–2016 NUM O
+: PUNCT O
+4.57 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.80 NUM O
+to PART O
+11.6 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.001 NUM O
+] PUNCT O
+) PUNCT O
+in ADP O
+autoantibody NOUN O
+- PUNCT O
+positive ADJ O
+RA NOUN B-AC
+, PUNCT O
+but CCONJ O
+not PART O
+in ADP O
+autoantibody NOUN O
+- PUNCT O
+negative ADJ O
+RA NOUN B-AC
+. PUNCT O
+In ADP O
+autoantibody NOUN O
+- PUNCT O
+positive ADJ O
+RA NOUN B-AC
+, PUNCT O
+mortality NOUN O
+decreased VERB O
+significantly ADV O
+after ADP O
+the DET O
+introduction NOUN O
+of ADP O
+treat NOUN O
+- PUNCT O
+to PART O
+- PUNCT O
+target NOUN O
+treatment NOUN O
+adjustments NOUN O
+( PUNCT O
+HR PROPN B-AC
+2006–2010 NUM O
+: PUNCT O
+0.56 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+0.34 NUM O
+to PART O
+0.92 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.023 NUM O
+] PUNCT O
+; PUNCT O
+HR PROPN B-AC
+2011–2016 NUM O
+: PUNCT O
+0.33 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+0.14 NUM O
+to PART O
+0.77 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.010 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+but CCONJ O
+not PART O
+in ADP O
+autoantibody NOUN O
+- PUNCT O
+negative ADJ O
+RA NOUN B-AC
+( PUNCT O
+HR PROPN B-AC
+2006–2010 NUM O
+: PUNCT O
+0.79 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+0.40 NUM O
+to PART O
+1.56 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.50 NUM O
+] PUNCT O
+; PUNCT O
+HR PROPN B-AC
+2011–2016 NUM O
+: PUNCT O
+0.36 NUM O
+[ PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+0.10 NUM O
+to PART O
+1.34 NUM O
+; PUNCT O
+p NOUN O
+= SYM O
+0.13 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Ethical ADJ O
+approval NOUN O
+was AUX O
+obtained VERB O
+from ADP O
+the DET O
+Uganda PROPN B-LF
+National PROPN I-LF
+Council PROPN I-LF
+of ADP I-LF
+Science PROPN I-LF
+and CCONJ I-LF
+Technology PROPN I-LF
+( PUNCT O
+UNCST PROPN B-AC
+) PUNCT O
+on ADP O
+20th NUM O
+December PROPN O
+2010 NUM O
+and CCONJ O
+an DET O
+extension NOUN O
+for ADP O
+the DET O
+study NOUN O
+granted VERB O
+on ADP O
+11th ADJ O
+November PROPN O
+2011 NUM O
+. PUNCT O
+
+GPC PROPN B-AC
+, PUNCT O
+Global PROPN B-LF
+Prokaryotic PROPN I-LF
+Census PROPN I-LF
+. PUNCT O
+
+PRESENILIN PROPN B-LF
+2 NUM I-LF
+( PUNCT O
+PSEN2 PROPN B-AC
+) PUNCT O
+is AUX O
+one NUM O
+of ADP O
+the DET O
+genes NOUN O
+mutated VERB O
+in ADP O
+early ADJ B-LF
+onset NOUN I-LF
+familial ADJ I-LF
+Alzheimer PROPN I-LF
+’s PART I-LF
+disease NOUN I-LF
+( PUNCT O
+EOfAD PROPN B-AC
+) PUNCT O
+. PUNCT O
+PSEN2 PROPN B-AC
+shares VERB O
+significant ADJ O
+amino NOUN O
+acid NOUN O
+sequence NOUN O
+identity NOUN O
+with ADP O
+another DET O
+EOfAD PROPN B-AC
+- PUNCT O
+related VERB O
+gene NOUN O
+PRESENILIN PROPN B-LF
+1 NUM I-LF
+( PUNCT O
+PSEN1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+partial ADJ O
+functional ADJ O
+redundancy NOUN O
+is AUX O
+seen VERB O
+between ADP O
+these DET O
+two NUM O
+genes NOUN O
+. PUNCT O
+
+For ADP O
+Cisplatin PROPN O
+, PUNCT O
+Docetaxel PROPN O
+, PUNCT O
+Doxorubicin PROPN O
+, PUNCT O
+and CCONJ O
+Etoposide PROPN O
+, PUNCT O
+the DET O
+best ADV O
+performance NOUN O
+was AUX O
+attained VERB O
+for ADP O
++ NOUN O
+-5%c NOUN O
+and CCONJ O
++ NOUN O
+-10%c NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+best ADV O
+- PUNCT O
+performing VERB O
+algorithms NOUN O
+were AUX O
+always ADV O
+SVM PROPN B-AC
+or CCONJ O
+Random PROPN B-LF
+Forests PROPN I-LF
+( PUNCT O
+RF PROPN B-AC
+) PUNCT O
+( PUNCT O
+S1 PROPN O
+– SYM O
+S7 NUM O
+Tables PROPN O
+) PUNCT O
+. PUNCT O
+
+DOT PROPN B-AC
+, PUNCT O
+directly ADV B-LF
+observed VERB I-LF
+therapy NOUN I-LF
+; PUNCT O
+SAT PROPN B-AC
+, PUNCT O
+self NOUN B-LF
+- PUNCT I-LF
+administered VERB I-LF
+therapy NOUN I-LF
+; PUNCT O
+TB PROPN B-AC
+, PUNCT O
+tuberculosis NOUN B-LF
+. PUNCT O
+
+To PART O
+define VERB O
+the DET O
+aldesleukin NOUN O
+dose NOUN O
+response NOUN O
+for ADP O
+Tregs NOUN B-AC
+and CCONJ O
+to PART O
+find VERB O
+doses NOUN O
+that PRON O
+increase VERB O
+Tregs NOUN B-AC
+physiologically ADV O
+for ADP O
+treatment NOUN O
+of ADP O
+T1D PROPN B-AC
+, PUNCT O
+a DET O
+statistical ADJ O
+and CCONJ O
+systematic ADJ O
+approach NOUN O
+was AUX O
+taken VERB O
+by ADP O
+analysing VERB O
+the DET O
+pharmacokinetics NOUN O
+and CCONJ O
+pharmacodynamics NOUN O
+of ADP O
+single ADJ O
+doses NOUN O
+of ADP O
+subcutaneous ADJ O
+aldesleukin NOUN O
+in ADP O
+the DET O
+Adaptive PROPN B-LF
+Study PROPN I-LF
+of ADP I-LF
+IL-2 PROPN I-LF
+Dose PROPN I-LF
+on ADP I-LF
+Regulatory PROPN I-LF
+T PROPN I-LF
+Cells PROPN I-LF
+in ADP I-LF
+Type PROPN I-LF
+1 NUM I-LF
+Diabetes PROPN I-LF
+( PUNCT O
+DILT1D PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+single ADJ O
+centre NOUN O
+, PUNCT O
+non ADJ O
+- PUNCT O
+randomised ADJ O
+, PUNCT O
+open ADJ O
+label NOUN O
+, PUNCT O
+adaptive ADJ O
+dose NOUN O
+- PUNCT O
+finding VERB O
+trial NOUN O
+with ADP O
+40 NUM O
+adult NOUN O
+participants NOUN O
+with ADP O
+recently ADV O
+diagnosed VERB O
+T1D. NOUN B-AC
+
+Standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT O
+SD NOUN B-AC
+) PUNCT O
+in ADP O
+parantheses NOUN O
+. PUNCT O
+
+Other ADJ O
+abbreviations NOUN O
+: PUNCT O
+ISOpull PROPN B-AC
+, PUNCT O
+isometric ADJ B-LF
+pulls NOUN I-LF
+; PUNCT O
+MVIC PROPN O
+, PUNCT O
+maximal ADJ O
+voluntary ADJ O
+isometric ADJ O
+contraction NOUN O
+; PUNCT O
+reps NOUN O
+, PUNCT O
+repetitions NOUN O
+; PUNCT O
+RM PROPN B-AC
+, PUNCT O
+repetition NOUN B-LF
+maximum ADJ I-LF
+; PUNCT O
+ROM PROPN B-AC
+, PUNCT O
+range NOUN B-LF
+of ADP I-LF
+motion NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+; PUNCT O
+TD PROPN B-AC
+- PUNCT B-AC
+MET PROPN B-AC
+, PUNCT O
+metastatic ADJ B-LF
+tumor NOUN I-LF
+diameter NOUN I-LF
+; PUNCT O
+AVI PROPN B-AC
+, PUNCT O
+afferent ADJ B-LF
+vascular ADJ I-LF
+invasion NOUN I-LF
+; PUNCT O
+EVI PROPN B-AC
+, PUNCT O
+efferent ADJ B-LF
+vascular ADJ I-LF
+invasion NOUN I-LF
+. PUNCT O
+
+Therefore ADV O
+, PUNCT O
+the DET O
+primary ADJ O
+analyses NOUN O
+employed VERB O
+logistic NOUN O
+regression NOUN O
+to ADP O
+estimate VERB O
+adjusted VERB O
+odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+ORs NOUN B-AC
+) PUNCT O
+and CCONJ O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+for ADP O
+the DET O
+first ADJ O
+event NOUN O
+of ADP O
+the DET O
+outcomes NOUN O
+of ADP O
+interest NOUN O
+( PUNCT O
+as ADP O
+a DET O
+binary ADJ O
+endpoint NOUN O
+, PUNCT O
+ignoring VERB O
+the DET O
+time NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+event NOUN O
+) PUNCT O
+. PUNCT O
+
+Somatic ADJ O
+genetic ADJ O
+CDKN2A PROPN O
+, PUNCT O
+TP53 PROPN O
+, PUNCT O
+and CCONJ O
+DNA NOUN O
+content NOUN O
+abnormalities NOUN O
+are AUX O
+common ADJ O
+in ADP O
+many ADJ O
+human ADJ O
+cancers NOUN O
+and CCONJ O
+their PRON O
+precursors NOUN O
+, PUNCT O
+including VERB O
+esophageal ADJ B-LF
+adenocarcinoma NOUN I-LF
+( PUNCT O
+EA PROPN B-AC
+) PUNCT O
+and CCONJ O
+Barrett PROPN B-LF
+'s PART I-LF
+esophagus NOUN I-LF
+( PUNCT O
+BE PROPN B-AC
+) PUNCT O
+, PUNCT O
+conditions NOUN O
+for ADP O
+which PRON O
+aspirin NOUN O
+and CCONJ O
+other ADJ O
+nonsteroidal ADJ B-LF
+anti ADJ I-LF
+- ADJ I-LF
+inflammatory ADJ I-LF
+drugs NOUN I-LF
+( PUNCT O
+NSAIDs PROPN B-AC
+) PUNCT O
+have AUX O
+been AUX O
+proposed VERB O
+as ADP O
+possible ADJ O
+chemopreventive ADJ O
+agents NOUN O
+; PUNCT O
+however ADV O
+, PUNCT O
+little ADJ O
+is AUX O
+known VERB O
+about ADP O
+the DET O
+ability NOUN O
+of ADP O
+a DET O
+biomarker NOUN O
+panel NOUN O
+to ADP O
+predict VERB O
+progression NOUN O
+to ADP O
+cancer NOUN O
+nor CCONJ O
+how SCONJ O
+NSAID PROPN B-AC
+use NOUN O
+may AUX O
+modulate VERB O
+progression NOUN O
+. PUNCT O
+
+The DET O
+ARROW PROPN B-AC
+trial NOUN O
+'s PART O
+primary ADJ O
+aim NOUN O
+was AUX O
+to ADP O
+compare VERB O
+two NUM O
+monitoring NOUN O
+strategies NOUN O
+in ADP O
+children NOUN O
+starting VERB O
+ART PROPN B-AC
+. PUNCT O
+Accordingly ADV O
+, PUNCT O
+children NOUN O
+were AUX O
+randomised VERB O
+to ADP O
+either CCONJ O
+the DET O
+“ PUNCT O
+clinically ADV B-LF
+driven VERB I-LF
+monitoring NOUN I-LF
+” PUNCT O
+( PUNCT O
+CDM PROPN B-AC
+) PUNCT O
+or CCONJ O
+“ PUNCT O
+laboratory ADJ B-LF
+and CCONJ I-LF
+clinical ADJ I-LF
+monitoring NOUN I-LF
+” PUNCT O
+( PUNCT O
+LCM PROPN B-AC
+) PUNCT O
+group NOUN O
+. PUNCT O
+
+For ADP O
+continuous ADJ O
+variables NOUN O
+, PUNCT O
+the DET O
+mean NOUN O
+and CCONJ O
+standard ADJ B-LF
+deviation NOUN I-LF
+( PUNCT O
+SD NOUN B-AC
+) PUNCT O
+of ADP O
+WC PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+, PUNCT O
+TG PROPN B-AC
+, PUNCT O
+HDL PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+FBG PROPN B-AC
+, PUNCT O
+systolic ADJ O
+BP PROPN B-AC
+, PUNCT O
+and CCONJ O
+diastolic ADJ O
+BP PROPN B-AC
+for ADP O
+HBsAg PROPN B-AC
+positive ADJ O
+subjects NOUN O
+and CCONJ O
+the DET O
+controls NOUN O
+were AUX O
+extracted VERB O
+. PUNCT O
+
+These DET O
+proteins NOUN O
+bind VERB O
+sequentially ADV O
+to ADP O
+the DET O
+translocase NOUN B-LF
+of ADP I-LF
+the DET I-LF
+outer ADJ I-LF
+membrane NOUN I-LF
+( PUNCT O
+TOM PROPN B-AC
+) PUNCT O
+complex NOUN O
+situated VERB O
+in ADP O
+the DET O
+outer ADJ B-LF
+mitochondrial ADJ I-LF
+membrane NOUN I-LF
+( PUNCT O
+OMM PROPN B-AC
+) PUNCT O
+and CCONJ O
+then ADV O
+to ADP O
+the DET O
+translocase NOUN B-LF
+of ADP I-LF
+the DET I-LF
+inner ADJ I-LF
+membrane NOUN I-LF
+23 NUM I-LF
+( PUNCT O
+TIM23 PROPN B-AC
+) PUNCT O
+complex NOUN O
+. PUNCT O
+
+Uncoupling VERB B-LF
+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+UCP1 PROPN B-AC
+) PUNCT O
+is AUX O
+exclusively ADV O
+expressed VERB O
+in ADP O
+BAT PROPN B-AC
+and CCONJ O
+is AUX O
+localized VERB O
+to ADP O
+the DET O
+inner ADJ O
+membrane NOUN O
+of ADP O
+the DET O
+mitochondria NOUN O
+. PUNCT O
+
+TPM PROPN B-AC
+, PUNCT O
+transcripts NOUN B-LF
+per ADP I-LF
+million NUM I-LF
+. PUNCT O
+
+The DET O
+project NOUN O
+aims VERB O
+to PART O
+resolve VERB O
+the DET O
+technical ADJ O
+, PUNCT O
+social ADJ O
+and CCONJ O
+economic ADJ O
+bottlenecks NOUN O
+for ADP O
+PMF PROPN B-AC
+. PUNCT O
+It PRON O
+takes VERB O
+a DET O
+product NOUN O
+- PUNCT O
+led VERB O
+approach NOUN O
+with ADP O
+five NUM O
+small ADJ B-LF
+to PART I-LF
+medium ADJ I-LF
+enterprises NOUN I-LF
+( PUNCT O
+SMEs PROPN B-AC
+) PUNCT O
+involved VERB O
+in ADP O
+the DET O
+production NOUN O
+of ADP O
+medical ADJ O
+, PUNCT O
+veterinary ADJ O
+and CCONJ O
+diagnostic ADJ O
+products NOUN O
+— PUNCT O
+it PRON O
+also ADV O
+aims VERB O
+to PART O
+involve VERB O
+all DET O
+relevant ADJ O
+stakeholders NOUN O
+in ADP O
+the DET O
+process NOUN O
+of ADP O
+developing VERB O
+these DET O
+platforms NOUN O
+, PUNCT O
+including VERB O
+scientists NOUN O
+, PUNCT O
+representatives NOUN O
+of ADP O
+PMF PROPN B-AC
+businesses NOUN O
+and CCONJ O
+the DET O
+public NOUN O
+at ADP O
+large ADJ O
+. PUNCT O
+
+Pre ADJ O
+- ADJ O
+procedural ADJ O
+anticoagulation NOUN O
+was AUX O
+performed VERB O
+with ADP O
+either CCONJ O
+warfarin NOUN O
+or CCONJ O
+non ADJ B-LF
+- ADJ I-LF
+vitamin ADJ I-LF
+K NOUN I-LF
+oral ADJ I-LF
+anticoagulant NOUN I-LF
+( PUNCT O
+NOAC PROPN B-AC
+) PUNCT O
+. PUNCT O
+Some DET O
+patient NOUN O
+was AUX O
+not PART O
+prescribed VERB O
+with ADP O
+anticoagulants NOUN O
+. PUNCT O
+
+After ADP O
+solid ADJ O
+organ NOUN O
+transplantation NOUN O
+, PUNCT O
+the DET O
+production NOUN O
+of ADP O
+donor NOUN B-LF
+- NOUN I-LF
+specific ADJ I-LF
+allo NOUN I-LF
+- NOUN I-LF
+antibodies NOUN I-LF
+( PUNCT O
+DSA PROPN B-AC
+) PUNCT O
+is AUX O
+involved VERB O
+in ADP O
+both CCONJ O
+acute ADJ O
+and CCONJ O
+chronic ADJ O
+allograft NOUN O
+rejection NOUN O
+[ PUNCT O
+3 NUM O
+, PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+Preadipocyte ADJ O
+expression NOUN O
+of ADP O
+the DET O
+angiogenic ADJ O
+genes NOUN O
+vascular ADJ B-LF
+endothelial ADJ I-LF
+growth NOUN I-LF
+factor NOUN I-LF
+( PUNCT O
+VEGF PROPN B-AC
+) PUNCT O
+and CCONJ O
+nuclear ADJ B-LF
+factor NOUN I-LF
+of ADP I-LF
+activated VERB I-LF
+T PROPN I-LF
+- PUNCT I-LF
+cells NOUN I-LF
+3 NUM I-LF
+( PUNCT O
+NFATC3 PROPN B-AC
+) PUNCT O
+was AUX O
+measured VERB O
+after ADP O
+recombinant ADJ O
+sFRP2 NOUN O
+exposure NOUN O
+. PUNCT O
+
+On ADP O
+the DET O
+other ADJ O
+hand NOUN O
+, PUNCT O
+proneural ADJ O
+genes NOUN O
+are AUX O
+basic ADJ B-LF
+helix NOUN I-LF
+- PUNCT I-LF
+loop NOUN I-LF
+- PUNCT I-LF
+helix NOUN I-LF
+( PUNCT O
+bHLH PROPN B-AC
+) PUNCT O
+transcription NOUN O
+factors NOUN O
+that PRON O
+promote VERB O
+cell NOUN O
+cycle NOUN O
+exit NOUN O
+and CCONJ O
+neural ADJ O
+commitment NOUN O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+( PUNCT O
+A X O
+) PUNCT O
+Schematic NOUN O
+of ADP O
+the DET O
+rAAV NOUN B-AC
+expression NOUN O
+cassette NOUN O
+with ADP O
+internal ADJ B-LF
+tandem NOUN I-LF
+repeats NOUN I-LF
+( PUNCT O
+ITR PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+mGluR6 NOUN B-LF
+enhancer NOUN I-LF
+element NOUN I-LF
+( PUNCT O
+GRM6 PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+sv40 NOUN B-LF
+eukaryotic ADJ I-LF
+promoter NOUN I-LF
+sequence NOUN I-LF
+( PUNCT O
+psv40 NOUN B-AC
+) PUNCT O
+, PUNCT O
+an DET O
+internal ADJ B-LF
+ribosomal ADJ I-LF
+entry NOUN I-LF
+site NOUN I-LF
+( PUNCT O
+IRES PROPN B-AC
+) PUNCT O
+, PUNCT O
+woodchuck NOUN B-LF
+posttranscriptional ADJ I-LF
+regulatory ADJ I-LF
+element NOUN I-LF
+( PUNCT O
+WPRE PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+bovine ADJ B-LF
+growth NOUN I-LF
+hormone NOUN I-LF
+polyadenylation NOUN I-LF
+sequence NOUN I-LF
+( PUNCT O
+BGHpA PROPN B-AC
+) PUNCT O
+. PUNCT O
+( PUNCT O
+B X O
+) PUNCT O
+Retinal ADJ O
+whole ADJ O
+mount NOUN O
+transduced VERB O
+by ADP O
+intravitreal NOUN O
+injection NOUN O
+and CCONJ O
+stained VERB O
+with ADP O
+an DET O
+antibody NOUN O
+against ADP O
+TurboFP635 PROPN O
+. PUNCT O
+
+HF PROPN B-AC
+health NOUN B-LF
+facility NOUN I-LF
+“ PUNCT O
+-“unknown PUNCT O
+third ADJ O
+quartile NOUN O
+. PUNCT O
+
+The DET O
+authors NOUN O
+of ADP O
+the DET O
+current ADJ O
+study NOUN O
+investigated VERB O
+and CCONJ O
+compared VERB O
+the DET O
+effects NOUN O
+of ADP O
+three NUM O
+general ADJ O
+anesthetics NOUN O
+, PUNCT O
+isoflurane NOUN B-LF
+( PUNCT O
+Iso PROPN B-AC
+) PUNCT O
+, PUNCT O
+medetomidine NOUN B-LF
+/ SYM I-LF
+midazolam NOUN I-LF
+/ SYM I-LF
+fentanyl NOUN I-LF
+( PUNCT O
+MMF PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+ketamine NOUN B-LF
+/ SYM I-LF
+xylazine NOUN I-LF
+( PUNCT O
+Keta NOUN B-AC
+/ SYM B-AC
+Xyl NOUN B-AC
+) PUNCT O
+, PUNCT O
+on ADP O
+neuronal ADJ O
+activity NOUN O
+of ADP O
+the DET O
+mouse NOUN O
+hippocampus NOUN O
+and CCONJ O
+memory NOUN O
+consolidation NOUN O
+at ADP O
+the DET O
+behavioral ADJ O
+level NOUN O
+. PUNCT O
+
+Online ADJ O
+fNIRS PROPN B-AC
+classification NOUN O
+of ADP O
+personal ADJ O
+questions NOUN O
+with ADP O
+known VERB O
+answers NOUN O
+and CCONJ O
+open ADJ O
+questions NOUN O
+using VERB O
+linear ADJ O
+support NOUN B-LF
+vector NOUN I-LF
+machine NOUN I-LF
+( PUNCT O
+SVM PROPN B-AC
+) PUNCT O
+resulted VERB O
+in ADP O
+an DET O
+above ADP O
+- PUNCT O
+chance NOUN O
+- PUNCT O
+level NOUN O
+correct ADJ O
+response NOUN O
+rate NOUN O
+over ADP O
+70 NUM O
+% PUNCT O
+. PUNCT O
+
+Thoracic ADJ B-LF
+ossification NOUN I-LF
+of ADP I-LF
+the DET I-LF
+ligamentum NOUN I-LF
+flavum NOUN I-LF
+( PUNCT O
+TOLF PROPN B-AC
+) PUNCT O
+is AUX O
+characterized VERB O
+by ADP O
+ectopic ADJ O
+bone NOUN O
+formation NOUN O
+in ADP O
+the DET O
+ligamentum NOUN O
+flavum NOUN O
+and CCONJ O
+is AUX O
+considered VERB O
+to PART O
+be AUX O
+a DET O
+leading VERB O
+cause NOUN O
+of ADP O
+thoracic ADJ O
+spinal ADJ O
+canal NOUN O
+stenosis NOUN O
+and CCONJ O
+myelopathy NOUN O
+. PUNCT O
+
+Insight NOUN O
+in ADP O
+hospitalizations NOUN O
+in ADP O
+long ADJ O
+- PUNCT O
+term NOUN O
+childhood NOUN B-LF
+cancer NOUN I-LF
+survivors NOUN I-LF
+( PUNCT O
+CCS PROPN B-AC
+) PUNCT O
+is AUX O
+useful ADJ O
+to PART O
+understand VERB O
+the DET O
+impact NOUN O
+of ADP O
+long ADJ O
+- PUNCT O
+term NOUN O
+morbidity NOUN O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+PRISMA PROPN B-AC
+, PUNCT O
+Preferred ADJ B-LF
+Reporting NOUN I-LF
+Items NOUN I-LF
+for ADP I-LF
+Systematic ADJ I-LF
+Reviews NOUN I-LF
+and CCONJ I-LF
+Meta NOUN I-LF
+- NOUN I-LF
+Analysis NOUN I-LF
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+ARR PROPN B-AC
+, PUNCT O
+annual ADJ B-LF
+rate NOUN I-LF
+of ADP I-LF
+reduction NOUN I-LF
+; PUNCT O
+LLT PROPN B-AC
+, PUNCT O
+Li PROPN B-LF
+– PUNCT I-LF
+Lee PROPN I-LF
+– PUNCT I-LF
+Tuljapurkar PROPN I-LF
+; PUNCT O
+UN PROPN B-AC
+IGME PROPN B-AC
+, PUNCT O
+United PROPN B-LF
+Nations PROPN I-LF
+Inter PROPN I-LF
+- PROPN I-LF
+agency PROPN I-LF
+Group PROPN I-LF
+for ADP I-LF
+Child PROPN I-LF
+Mortality PROPN I-LF
+Estimation PROPN I-LF
+. PUNCT O
+
+Severe ADJ O
+alpha-1 NUM B-LF
+- PUNCT I-LF
+antitrypsin NOUN I-LF
+deficiency NOUN I-LF
+( PUNCT O
+AATD PROPN B-AC
+, PUNCT O
+MIM PROPN O
+# NOUN O
+613490 NUM O
+) PUNCT O
+affects VERB O
+approximately ADV O
+1 NUM O
+in ADP O
+2000 NUM O
+of ADP O
+the DET O
+Northern ADJ O
+European ADJ O
+population NOUN O
+. PUNCT O
+
+TTP NOUN B-AC
+= PUNCT O
+time NOUN B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+peak NOUN I-LF
+. PUNCT O
+
+Computed ADJ B-LF
+tomography NOUN I-LF
+( PUNCT O
+CT NOUN B-AC
+) PUNCT O
+scan NOUN O
+is AUX O
+widely ADV O
+used VERB O
+in ADP O
+clinics NOUN O
+for ADP O
+AF PROPN B-AC
+patients NOUN O
+especially ADV O
+when SCONJ O
+undergoing VERB O
+radiofrequency NOUN O
+catheter NOUN O
+ablation NOUN O
+. PUNCT O
+
+Clinical ADJ B-LF
+medication NOUN I-LF
+reviews NOUN I-LF
+( PUNCT O
+CMRs NOUN B-AC
+) PUNCT O
+are AUX O
+increasingly ADV O
+performed VERB O
+in ADP O
+older ADJ O
+persons NOUN O
+with ADP O
+multimorbidity NOUN O
+and CCONJ O
+polypharmacy NOUN O
+to PART O
+reduce VERB O
+drug NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+problems NOUN I-LF
+( PUNCT O
+DRPs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Cu PROPN B-AC
+reduced VERB O
+triglyceride NOUN B-LF
+( PUNCT O
+TG NOUN B-AC
+) PUNCT O
+storage NOUN O
+and CCONJ O
+secretion NOUN O
+. PUNCT O
+
+Repair NOUN O
+of ADP O
+DNA NOUN O
+breaks NOUN O
+by ADP O
+single ADJ B-LF
+- PUNCT I-LF
+strand NOUN I-LF
+annealing NOUN I-LF
+( PUNCT O
+SSA NOUN B-AC
+) PUNCT O
+is AUX O
+a DET O
+major ADJ O
+mechanism NOUN O
+for ADP O
+the DET O
+maintenance NOUN O
+of ADP O
+genomic ADJ O
+integrity NOUN O
+. PUNCT O
+
+Among ADP O
+the DET O
+947,091 NUM O
+patients NOUN O
+who PRON O
+underwent VERB O
+PCIs NOUN B-AC
+included VERB O
+in ADP O
+the DET O
+analytic ADJ O
+cohort NOUN O
+, PUNCT O
+the DET O
+mean NOUN O
+( PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+[ PUNCT O
+SD NOUN B-AC
+] PUNCT O
+) PUNCT O
+of ADP O
+their PRON O
+age NOUN O
+was AUX O
+64.8 NUM O
+( PUNCT O
+12.2 NUM O
+) PUNCT O
+years NOUN O
+, PUNCT O
+and CCONJ O
+636,078 NUM O
+( PUNCT O
+32.8 NUM O
+% NOUN O
+) PUNCT O
+were AUX O
+women NOUN O
+( PUNCT O
+S4 PROPN O
+Table PROPN O
+) PUNCT O
+. PUNCT O
+
+Many ADJ O
+countries NOUN O
+in ADP O
+sub ADJ O
+- PUNCT O
+Saharan PROPN O
+Africa PROPN O
+use VERB O
+sulfadoxine NOUN B-LF
+- PUNCT I-LF
+pyrimethamine NOUN I-LF
+( PUNCT O
+SP PROPN B-AC
+) PUNCT O
+for ADP O
+the DET O
+treatment NOUN O
+of ADP O
+clinical ADJ O
+malaria NOUN O
+in ADP O
+pregnancy NOUN O
+or CCONJ O
+have AUX O
+introduced VERB O
+intermittent ADJ B-LF
+preventive ADJ I-LF
+treatment NOUN I-LF
+in ADP I-LF
+pregnancy NOUN I-LF
+( PUNCT O
+IPTp NOUN B-AC
+) PUNCT O
+with ADP O
+SP PROPN B-AC
+as ADP O
+national ADJ O
+policy NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Source NOUN O
+data NOUN O
+for ADP O
+A PROPN O
+- PUNCT O
+C PROPN O
+and CCONJ O
+E PROPN O
+- PUNCT O
+H PROPN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+the DET O
+supplemental ADJ O
+data NOUN O
+file NOUN O
+( PUNCT O
+S1 PROPN O
+Data PROPN O
+) PUNCT O
+. PUNCT O
+2C PROPN B-AC
+, PUNCT O
+2 NUM B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+; PUNCT O
+Dppa2 PROPN O
+, PUNCT O
+developmental ADJ O
+pluripotency NOUN O
+associated VERB O
+2 NUM O
+; PUNCT O
+Dux PROPN B-AC
+, PUNCT O
+double ADJ B-LF
+homeobox NOUN I-LF
+; PUNCT O
+ESC PROPN B-AC
+, PUNCT O
+embryonic ADJ B-LF
+stem NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+IF PROPN B-AC
+, PUNCT O
+immunofluorescence NOUN B-LF
+; PUNCT O
+MERVL PROPN B-AC
+, PUNCT O
+murine NOUN O
+endogenous ADJ O
+retrovirus NOUN O
+- PUNCT O
+L NOUN O
+; PUNCT O
+NC PROPN O
+, PUNCT O
+negative ADJ O
+control NOUN O
+; PUNCT O
+Pias4 PROPN O
+, PUNCT O
+protein NOUN O
+inhibitor NOUN O
+of ADP O
+activated VERB O
+STAT PROPN O
+4 NUM O
+; PUNCT O
+PLA PROPN B-AC
+, PUNCT O
+proximity NOUN B-LF
+ligation NOUN I-LF
+assay NOUN I-LF
+; PUNCT O
+siRNA PROPN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+; PUNCT O
+Sumo2 PROPN O
+, PUNCT O
+small ADJ O
+ubiquitin NOUN O
+- PUNCT O
+like ADJ O
+modifier NOUN O
+2 NUM O
+; PUNCT O
+tdTomato PROPN B-AC
+, PUNCT O
+tandem ADJ B-LF
+dimeric ADJ I-LF
+Tomato PROPN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+PCR PROPN B-AC
+, PUNCT O
+Polymerase PROPN B-LF
+Chain PROPN I-LF
+Reaction PROPN I-LF
+; PUNCT O
+IQR PROPN O
+, PUNCT O
+Inter PROPN O
+Quartile PROPN O
+Range PROPN O
+. PUNCT O
+
+The DET O
+young ADJ O
+root NOUN O
+tissue NOUN O
+of ADP O
+rice NOUN O
+plant NOUN O
+( PUNCT O
+Oryza NOUN O
+sativa NOUN O
+‘ PUNCT O
+IR36 PROPN O
+’ PUNCT O
+) PUNCT O
+was AUX O
+treated VERB O
+similarly ADV O
+and CCONJ O
+used VERB O
+as ADP O
+the DET O
+reference NOUN O
+standard NOUN O
+( PUNCT O
+1.01pg/2C NOUN O
+) PUNCT O
+[ X O
+21 NUM O
+] X O
+The DET O
+nuclei NOUN O
+of ADP O
+both DET O
+the DET O
+plants NOUN O
+were AUX O
+then ADV O
+treated VERB O
+with ADP O
+50 NUM O
+μg NOUN O
+ml-1 NUM O
+RNase NOUN O
+A NOUN O
+and CCONJ O
+simultaneously ADV O
+stained VERB O
+with ADP O
+50 NUM O
+μg NOUN O
+ml-1 NUM O
+of ADP O
+propidium NOUN B-LF
+iodide NOUN I-LF
+( PUNCT O
+PI PROPN B-AC
+) PUNCT O
+prior ADV O
+to ADP O
+incubation NOUN O
+on ADP O
+ice NOUN O
+for ADP O
+10 NUM O
+min NOUN O
+. PUNCT O
+
+By ADP O
+comparing VERB O
+lipid NOUN O
+profiles NOUN O
+of ADP O
+phosphate NOUN O
+- PUNCT O
+starved VERB O
+WT PROPN O
+C. PROPN O
+neoformans NOUN O
+, PUNCT O
+PHO4 NOUN O
+( PUNCT O
+pho4Δ NOUN O
+) PUNCT O
+and CCONJ O
+BTA1 PROPN O
+( PUNCT O
+bta1Δ NOUN O
+) PUNCT O
+deletion NOUN O
+mutants NOUN O
+using VERB O
+thin ADJ O
+layer NOUN O
+chromatography NOUN O
+and CCONJ O
+liquid NOUN O
+chromatography NOUN O
+mass NOUN O
+spectrometry NOUN O
+, PUNCT O
+we PRON O
+showed VERB O
+that SCONJ O
+phosphatidylcholine NOUN B-LF
+( PUNCT O
+PC NOUN B-AC
+) PUNCT O
+is AUX O
+substituted VERB O
+by ADP O
+the DET O
+phosphorus NOUN O
+- PUNCT O
+free ADJ O
+betaine NOUN O
+lipids NOUN O
+diacylglyceryl NOUN B-LF
+- PUNCT I-LF
+N NOUN I-LF
+, PUNCT I-LF
+N NOUN I-LF
+, PUNCT I-LF
+N NOUN I-LF
+- PUNCT I-LF
+trimethylhomoserine NOUN I-LF
+( PUNCT O
+DGTS PROPN B-AC
+) PUNCT O
+and CCONJ O
+diacylgyceryl NOUN B-LF
+hydroxymethyl NOUN I-LF
+- PUNCT I-LF
+N NOUN I-LF
+, PUNCT I-LF
+N NOUN I-LF
+, PUNCT I-LF
+N NOUN I-LF
+- PUNCT I-LF
+trimethyl NOUN I-LF
+- PUNCT I-LF
+beta NOUN I-LF
+- PUNCT I-LF
+alanine NOUN I-LF
+( PUNCT O
+DGTA PROPN B-AC
+) PUNCT O
+in ADP O
+a DET O
+Pho4- NOUN O
+and CCONJ O
+Bta1 NOUN O
+- PUNCT O
+dependent ADJ O
+manner NOUN O
+, PUNCT O
+and CCONJ O
+that SCONJ O
+BTA1 PROPN O
+encodes VERB O
+a DET O
+functional ADJ O
+DGTS PROPN B-AC
+synthase NOUN O
+. PUNCT O
+
+The DET O
+prediction NOUN B-LF
+report NOUN I-LF
+status NOUN O
+is AUX O
+stored VERB O
+in ADP O
+RSU PROPN O
+- PUNCT O
+PR PROPN B-AC
+register NOUN O
+as SCONJ O
+shown VERB O
+in ADP O
+Table NOUN O
+5 NUM O
+. PUNCT O
+
+In ADP O
+intestinal ADJ O
+tissue NOUN O
+, PUNCT O
+IL-22 NOUN B-AC
+is AUX O
+mainly ADV O
+produced VERB O
+by ADP O
+ILC3 PROPN O
+cells NOUN O
+[ PUNCT O
+59 NUM O
+] PUNCT O
+, PUNCT O
+CD4 PROPN O
++ NOUN O
+T PROPN O
+cells NOUN O
+[ PUNCT O
+77 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+, PUNCT O
+to ADP O
+a DET O
+lesser ADJ O
+extent NOUN O
+, PUNCT O
+CD8 PROPN O
++ NOUN O
+T PROPN O
+cells NOUN O
+, PUNCT O
+T PROPN O
+- PUNCT O
+cell NOUN O
+receptor NOUN O
+( PUNCT O
+TCR)γδ NOUN O
+T PROPN O
+cells NOUN O
+, PUNCT O
+neutrophils NOUN O
+, PUNCT O
+and CCONJ O
+natural ADJ B-LF
+killer NOUN I-LF
+( PUNCT O
+NK PROPN B-AC
+) PUNCT O
+cells NOUN O
+[ PUNCT O
+78,79 NUM O
+] PUNCT O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+. PUNCT O
+
+No DET O
+personal ADJ O
+medical ADJ O
+history NOUN O
+of ADP O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+( PUNCT O
+MI NOUN B-AC
+) PUNCT O
+, PUNCT O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CAD PROPN B-AC
+) PUNCT O
+, PUNCT O
+peripheral ADJ B-LF
+arterial ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+PAD PROPN B-AC
+) PUNCT O
+, PUNCT O
+stroke NOUN O
+, PUNCT O
+cancer NOUN O
+, PUNCT O
+autoimmune ADJ O
+/ SYM O
+genetic ADJ O
+disease NOUN O
+, PUNCT O
+endocrine ADJ O
+disease NOUN O
+, PUNCT O
+diabetes NOUN O
+mellitus NOUN O
+, PUNCT O
+psychiatric ADJ O
+illness NOUN O
+, PUNCT O
+asthma NOUN O
+, PUNCT O
+or CCONJ O
+chronic ADJ O
+lung NOUN O
+disease NOUN O
+and CCONJ O
+chronic ADJ O
+infective ADJ O
+disease NOUN O
+. PUNCT O
+
+Although SCONJ O
+previous ADJ O
+studies NOUN O
+conducted VERB O
+in ADP O
+sub ADJ B-LF
+- PUNCT I-LF
+Saharan PROPN I-LF
+Africa PROPN I-LF
+( PUNCT O
+SSA PROPN B-AC
+) PUNCT O
+have AUX O
+made VERB O
+mention NOUN O
+of ADP O
+similar ADJ O
+barriers NOUN O
+to ADP O
+integrating VERB O
+NCD PROPN B-AC
+management NOUN O
+, PUNCT O
+majority NOUN O
+of ADP O
+the DET O
+studies NOUN O
+focused VERB O
+on ADP O
+other ADJ O
+chronic ADJ O
+diseases NOUN O
+( PUNCT O
+i.e. X O
+cervical ADJ O
+cancer NOUN O
+, PUNCT O
+mental ADJ O
+health NOUN O
+, PUNCT O
+diabetes NOUN O
+) PUNCT O
+but CCONJ O
+not PART O
+hypertension NOUN O
+, PUNCT O
+which PRON O
+is AUX O
+characterized VERB O
+as ADP O
+a DET O
+silent ADJ O
+killer NOUN O
+and CCONJ O
+is AUX O
+currently ADV O
+the DET O
+leading VERB O
+risk NOUN O
+factor NOUN O
+for ADP O
+CVD.[17–21 NUM B-AC
+] PUNCT O
+The DET O
+identification NOUN O
+of ADP O
+barriers NOUN O
+or CCONJ O
+enablers NOUN O
+by ADP O
+themselves PRON O
+are AUX O
+also ADV O
+not PART O
+a DET O
+new ADJ O
+undertaking NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+; PUNCT O
+however ADV O
+, PUNCT O
+our PRON O
+approach NOUN O
+to ADP O
+the DET O
+assessment NOUN O
+of ADP O
+these DET O
+barriers NOUN O
+across ADP O
+multiple ADJ O
+clinical ADJ O
+sites NOUN O
+is AUX O
+unique ADJ O
+and CCONJ O
+may AUX O
+potentially ADV O
+inform VERB O
+the DET O
+development NOUN O
+of ADP O
+interventions NOUN O
+targeting VERB O
+the DET O
+capabilities NOUN O
+, PUNCT O
+opportunities NOUN O
+, PUNCT O
+and CCONJ O
+motivations NOUN O
+for ADP O
+successful ADJ O
+service NOUN O
+delivery NOUN O
+of ADP O
+evidence NOUN O
+- PUNCT O
+based VERB O
+hypertension NOUN O
+interventions NOUN O
+within ADP O
+HIV PROPN B-AC
+clinics NOUN O
+. PUNCT O
+
+Performance NOUN O
+in ADP O
+distinguishing VERB O
+early ADJ O
+stage NOUN O
+PDAC PROPN B-AC
+( PUNCT O
+stage NOUN O
+I NOUN O
+– SYM O
+II NOUN O
+) PUNCT O
+( PUNCT O
+n NOUN O
+= SYM O
+80 NUM O
+) PUNCT O
+from ADP O
+control NOUN O
+samples NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+92 NUM O
+) PUNCT O
+( PUNCT O
+A NOUN O
+and CCONJ O
+C NOUN O
+) PUNCT O
+and CCONJ O
+benign ADJ O
+samples NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+108 NUM O
+) PUNCT O
+( PUNCT O
+B NOUN O
+and CCONJ O
+D NOUN O
+) PUNCT O
+. PUNCT O
+ROC PROPN B-AC
+curves NOUN O
+of ADP O
+CA19 PROPN O
+- PUNCT O
+9 NUM O
+and CCONJ O
+biomarker NOUN O
+panel NOUN O
+alone ADV O
+and CCONJ O
+in ADP O
+combination NOUN O
+( PUNCT O
+A NOUN O
+and CCONJ O
+B NOUN O
+) PUNCT O
+; PUNCT O
+summary NOUN O
+of ADP O
+the DET O
+performances NOUN O
+( PUNCT O
+C NOUN O
+and CCONJ O
+D NOUN O
+) PUNCT O
+. PUNCT O
+AUC PROPN B-AC
+, PUNCT O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+receiver NOUN I-LF
+operating NOUN I-LF
+characteristic NOUN I-LF
+curve NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+PDAC PROPN B-AC
+, PUNCT O
+pancreatic ADJ B-LF
+ductal ADJ I-LF
+adenocarcinoma NOUN I-LF
+; PUNCT O
+ROC PROPN B-AC
+, PUNCT O
+receiver NOUN B-LF
+operating NOUN I-LF
+characteristic NOUN I-LF
+; PUNCT O
+SN PROPN B-AC
+, PUNCT O
+sensitivity NOUN B-LF
+; PUNCT O
+SP PROPN B-AC
+, PUNCT O
+specificity NOUN B-LF
+. PUNCT O
+
+Total ADJ O
+RNA PROPN O
+quantity NOUN O
+was AUX O
+determined VERB O
+by ADP O
+the DET O
+absorbance NOUN O
+at ADP O
+260 NUM O
+nm NOUN O
+using VERB O
+a DET O
+nanoVue NOUN O
+spectrophotometer NOUN O
+( PUNCT O
+GE PROPN O
+Healthcare PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+. PUNCT O
+RNA PROPN O
+Integrity PROPN O
+was AUX O
+ensured VERB O
+by ADP O
+obtaining VERB O
+an DET O
+RNA PROPN B-LF
+Integrity PROPN I-LF
+Number PROPN I-LF
+— PUNCT O
+RIN PROPN B-AC
+> SYM O
+8 NUM O
+with ADP O
+Agilent PROPN O
+2100 NUM O
+Bioanalyzer PROPN O
+( PUNCT O
+Agilent PROPN O
+Technologies PROPN O
+, PUNCT O
+Germany PROPN O
+) PUNCT O
+[ PUNCT O
+30 NUM O
+] PUNCT O
+. PUNCT O
+
+Analyses NOUN O
+of ADP O
+human ADJ O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PBMCs PROPN B-AC
+) PUNCT O
+can AUX O
+be AUX O
+done VERB O
+on ADP O
+freshly ADV O
+collected VERB O
+blood NOUN O
+samples NOUN O
+or CCONJ O
+on ADP O
+cryopreserved ADJ O
+samples NOUN O
+. PUNCT O
+
+As SCONJ O
+expected VERB O
+from ADP O
+randomization NOUN O
+, PUNCT O
+baseline NOUN O
+characteristics NOUN O
+were AUX O
+similar ADJ O
+between ADP O
+arms NOUN O
+, PUNCT O
+with ADP O
+the DET O
+exception NOUN O
+of ADP O
+enrollment NOUN O
+head NOUN O
+circumference NOUN O
+z NOUN O
+- NOUN O
+scores NOUN O
+, PUNCT O
+which PRON O
+were AUX O
+higher ADJ O
+in ADP O
+the DET O
+nicotinamide NOUN O
+group NOUN O
+compared VERB O
+to ADP O
+placebo NOUN O
+( PUNCT O
+0.03 NUM O
+versus ADP O
+−0.09 NUM O
+, PUNCT O
+difference NOUN O
+0.12 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ X O
+CI NOUN B-AC
+] X O
+−0.249 NUM O
+, PUNCT O
+−0.01 NUM O
+) PUNCT O
+( PUNCT O
+Table PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+RR PROPN B-AC
+, PUNCT O
+risk NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+Underdetection NOUN O
+may AUX O
+also ADV O
+proceed VERB O
+from ADP O
+the DET O
+imperfect ADJ O
+characteristics NOUN O
+of ADP O
+RT PROPN B-AC
+- PUNCT B-AC
+PCR PROPN B-AC
+( PUNCT O
+reverse ADJ B-LF
+transcription NOUN I-LF
+- PUNCT I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+) PUNCT O
+tests NOUN O
+used VERB O
+to PART O
+identify VERB O
+infected ADJ O
+cases NOUN O
+. PUNCT O
+
+A DET O
+Community NOUN B-LF
+- PUNCT I-LF
+Led VERB I-LF
+Total PROPN I-LF
+Sanitation PROPN I-LF
+and CCONJ I-LF
+Hygiene PROPN I-LF
+program NOUN I-LF
+( PUNCT O
+CLTSH PROPN B-AC
+) PUNCT O
+has AUX O
+been AUX O
+put VERB O
+into ADP O
+practice NOUN O
+in ADP O
+all DET O
+rural ADJ O
+Kebeles PROPN O
+since SCONJ O
+2013 NUM O
+. PUNCT O
+
+The DET O
+progress NOUN O
+of ADP O
+the DET O
+reaction NOUN O
+was AUX O
+followed VERB O
+by ADP O
+high ADJ B-LF
+- PUNCT I-LF
+performance NOUN I-LF
+liquid NOUN I-LF
+chromatography NOUN I-LF
+( PUNCT O
+HPLC PROPN B-AC
+) PUNCT O
+analyses NOUN O
+. PUNCT O
+
+CaM PROPN B-AC
+, PUNCT O
+calmodulin NOUN B-LF
+; PUNCT O
+SR NOUN B-AC
+- PUNCT B-AC
+CD PROPN B-AC
+, PUNCT O
+synchrotron NOUN B-LF
+radiation NOUN I-LF
+circular ADJ I-LF
+dichroism NOUN I-LF
+. PUNCT O
+
+Error- NOUN O
+and CCONJ O
+feedback NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+potentials NOUN I-LF
+( PUNCT O
+error NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+negativity NOUN I-LF
+[ X O
+ERN PROPN B-AC
+] X O
+and CCONJ O
+feedback NOUN O
+potentials NOUN O
+[ X O
+FRPs PROPN B-AC
+] X O
+) PUNCT O
+recorded VERB O
+over ADP O
+the DET O
+medial ADJ O
+part NOUN O
+of ADP O
+the DET O
+frontal ADJ O
+lobe NOUN O
+in ADP O
+electroencephalography NOUN B-LF
+( PUNCT O
+EEG PROPN B-AC
+) PUNCT O
+[ X O
+5–7 NUM O
+] X O
+, PUNCT O
+electrocorticography NOUN B-LF
+( PUNCT O
+ECoG PROPN B-AC
+) PUNCT O
+[ X O
+8 NUM O
+] X O
+, PUNCT O
+and CCONJ O
+local ADJ B-LF
+field NOUN I-LF
+potential NOUN I-LF
+( PUNCT O
+LFP PROPN B-AC
+) PUNCT O
+[ X O
+9 NUM O
+] X O
+differentiate VERB O
+outcome NOUN O
+valences NOUN O
+. PUNCT O
+
+To PART O
+evaluate VERB O
+plasma NOUN O
+membrane NOUN O
+integrity NOUN O
+, PUNCT O
+cells NOUN O
+were AUX O
+grown VERB O
+in ADP O
+a DET O
+48 NUM O
+- PUNCT O
+well NOUN O
+microplate NOUN O
+, PUNCT O
+and CCONJ O
+a DET O
+commercial ADJ O
+kit NOUN O
+by ADP O
+the DET O
+decrease NOUN O
+of ADP O
+OD NOUN O
+at ADP O
+340 NUM O
+nm NOUN O
+( PUNCT O
+Wiener PROPN O
+lab NOUN O
+) PUNCT O
+was AUX O
+used VERB O
+to PART O
+measure VERB O
+the DET O
+release NOUN O
+of ADP O
+the DET O
+cytoplasmic ADJ O
+enzyme NOUN O
+lactate NOUN B-LF
+dehydrogenase NOUN I-LF
+( PUNCT O
+LDH PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+LLoQ PROPN O
+, PUNCT O
+lower ADJ O
+limit NOUN O
+of ADP O
+quantification NOUN O
+; PUNCT O
+PP PROPN B-AC
+, PUNCT O
+per ADP B-LF
+- PUNCT I-LF
+protocol NOUN I-LF
+; PUNCT O
+P3 PROPN B-AC
+, PUNCT O
+placebo NOUN B-LF
+group NOUN I-LF
+3 NUM I-LF
+; PUNCT O
+q NOUN O
+, PUNCT O
+quodque NOUN O
+; PUNCT O
+SC PROPN B-AC
+, PUNCT O
+subcutaneous ADJ B-LF
+; PUNCT O
+T1 PROPN B-AC
+, PUNCT O
+treatment NOUN B-LF
+group NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+T2 PROPN B-AC
+, PUNCT O
+treatment NOUN B-LF
+group NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+T3 PROPN B-AC
+, PUNCT O
+treatment NOUN B-LF
+group NOUN I-LF
+3 NUM I-LF
+; PUNCT O
+T4 PROPN B-AC
+, PUNCT O
+treatment NOUN B-LF
+group NOUN I-LF
+4 NUM I-LF
+; PUNCT O
+T5 PROPN B-AC
+, PUNCT O
+treatment NOUN B-LF
+group NOUN I-LF
+5 NUM I-LF
+. PUNCT O
+
+CDS PROPN B-AC
+, PUNCT O
+coding VERB B-LF
+DNA NOUN I-LF
+sequence NOUN I-LF
+; PUNCT O
+NGS PROPN O
+, PUNCT O
+next ADJ O
+- PUNCT O
+generation NOUN O
+sequencing NOUN O
+; PUNCT O
+RPF PROPN B-AC
+, PUNCT O
+ribosome NOUN B-LF
+- PUNCT I-LF
+protected VERB I-LF
+mRNA NOUN I-LF
+fragment NOUN I-LF
+; PUNCT O
+RPKM PROPN B-AC
+, PUNCT O
+reads NOUN B-LF
+per ADP I-LF
+kilobase NOUN I-LF
+of ADP I-LF
+transcript NOUN I-LF
+per ADP I-LF
+million NUM I-LF
+mapped VERB I-LF
+reads NOUN I-LF
+; PUNCT O
+uORF PROPN B-AC
+, PUNCT O
+upstream ADJ B-LF
+open ADJ I-LF
+reading NOUN I-LF
+frame NOUN I-LF
+; PUNCT O
+UTR PROPN B-AC
+, PUNCT O
+untranslated ADJ B-LF
+region NOUN I-LF
+. PUNCT O
+
+SMA PROPN B-LF
+type NOUN I-LF
+III NUM I-LF
+– PUNCT O
+In ADP O
+our PRON O
+cohort NOUN O
+of ADP O
+SMA3 PROPN B-AC
+, PUNCT O
+FVC PROPN B-AC
+and CCONJ O
+FEV1 PROPN B-AC
+were AUX O
+within ADP O
+predicted VERB O
+values NOUN O
+, PUNCT O
+with ADP O
+slightly ADV O
+lower ADJ O
+values NOUN O
+of ADP O
+PCF PROPN B-AC
+, PUNCT O
+and CCONJ O
+normal ADJ O
+ventilatory ADJ O
+and CCONJ O
+thoraco ADJ O
+- PUNCT O
+abdominal ADJ O
+patterns NOUN O
+. PUNCT O
+
+We PRON O
+recently ADV O
+identified VERB O
+the DET O
+cystein NOUN B-LF
+- ADJ I-LF
+rich ADJ I-LF
+inter ADJ I-LF
+- ADJ I-LF
+domain ADJ I-LF
+region NOUN I-LF
+1α NUM I-LF
+( PUNCT O
+CIDR1α NOUN B-AC
+) PUNCT O
+of ADP O
+the DET O
+Plasmodium PROPN O
+falciparum NOUN O
+membrane NOUN O
+protein NOUN O
+1 NUM O
+as ADP O
+a DET O
+polyclonal ADJ O
+B NOUN O
+cell NOUN O
+activator NOUN O
+that PRON O
+preferentially ADV O
+activates VERB O
+the DET O
+memory NOUN O
+compartment NOUN O
+, PUNCT O
+where SCONJ O
+EBV PROPN B-AC
+is AUX O
+known VERB O
+to PART O
+persist VERB O
+. PUNCT O
+
+Intra ADJ O
+- PUNCT O
+class NOUN O
+correlation NOUN O
+coefficients NOUN O
+( PUNCT O
+ICC NOUN B-AC
+) PUNCT O
+for ADP O
+surface NOUN O
+( PUNCT O
+in ADP O
+mm2 NUM O
+) PUNCT O
+and CCONJ O
+depth NOUN O
+( PUNCT O
+in ADP O
+mm NOUN O
+) PUNCT O
+between ADP O
+flat ADJ O
+panel NOUN O
+computed VERB O
+tomography NOUN O
+arthrography NOUN O
+( PUNCT O
+FPCT NOUN B-AC
+- PUNCT B-AC
+A NOUN B-AC
+) PUNCT O
+, PUNCT O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+arthrography NOUN I-LF
+( PUNCT O
+MR NOUN B-AC
+- PUNCT B-AC
+A NOUN B-AC
+) PUNCT O
+and CCONJ O
+cast VERB O
+specimens NOUN O
+. PUNCT O
+
+Importantly ADV O
+, PUNCT O
+the DET O
+simulations NOUN O
+only ADV O
+consider VERB O
+base NOUN O
+substitutions NOUN O
+, PUNCT O
+not PART O
+insertions NOUN B-LF
+or CCONJ I-LF
+deletions NOUN I-LF
+( PUNCT O
+indels NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Changes NOUN O
+in ADP O
+blood NOUN B-LF
+oxygen NOUN I-LF
+level NOUN I-LF
+– PUNCT I-LF
+dependent ADJ I-LF
+( PUNCT O
+BOLD PROPN B-AC
+) PUNCT O
+responses NOUN O
+elicited VERB O
+by ADP O
+congruent ADJ O
+audiovisual ADJ O
+stimuli NOUN O
+( PUNCT O
+AV PROPN O
+) PUNCT O
+have AUX O
+been AUX O
+compared VERB O
+to ADP O
+auditory ADJ O
+- PUNCT O
+only ADV O
+( PUNCT O
+AO NOUN O
+) PUNCT O
+, PUNCT O
+visual ADJ O
+- PUNCT O
+only ADV O
+( PUNCT O
+VO NOUN O
+) PUNCT O
+, PUNCT O
+their PRON O
+sum NOUN O
+( PUNCT O
+AO NOUN O
++ SYM O
+VO NOUN O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+their PRON O
+conjunction NOUN O
+( PUNCT O
+AO NOUN O
+∩ SYM O
+VO NOUN O
+) PUNCT O
+. PUNCT O
+Greater ADJ O
+activation NOUN O
+for ADP O
+the DET O
+congruent ADJ O
+audiovisual ADJ O
+condition NOUN O
+( PUNCT O
+AV PROPN O
+) PUNCT O
+compared VERB O
+to ADP O
+others NOUN O
+has AUX O
+been AUX O
+interpreted VERB O
+as ADP O
+a DET O
+signature NOUN O
+of ADP O
+audiovisual ADJ O
+speech NOUN O
+integration NOUN O
+. PUNCT O
+
+To PART O
+test VERB O
+the DET O
+hypothesis NOUN O
+that SCONJ O
+IPs NOUN B-AC
+and CCONJ O
+other ADJ O
+metabolites NOUN O
+modulate VERB O
+the DET O
+translocation NOUN O
+of ADP O
+dNTPs NOUN B-AC
+through ADP O
+CA PROPN O
+oligomers NOUN O
+, PUNCT O
+we PRON O
+have AUX O
+employed VERB O
+a DET O
+multipronged ADJ O
+approach NOUN O
+combining VERB O
+all DET O
+- PUNCT O
+atom NOUN O
+molecular ADJ B-LF
+dynamics NOUN I-LF
+( PUNCT O
+MD PROPN B-AC
+) PUNCT O
+simulations NOUN O
+[ PUNCT O
+19 NUM O
+] PUNCT O
+, PUNCT O
+atomic ADJ B-LF
+force NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT O
+AFM PROPN B-AC
+) PUNCT O
+, PUNCT O
+transmission NOUN B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+( PUNCT O
+TEM PROPN B-AC
+) PUNCT O
+, PUNCT O
+confocal ADJ O
+microscopy NOUN O
+, PUNCT O
+and CCONJ O
+virus NOUN O
+infectivity NOUN O
+assays NOUN O
+. PUNCT O
+
+HCP PROPN B-AC
+, PUNCT O
+healthcare NOUN B-LF
+professional NOUN I-LF
+. PUNCT O
+
+AUC PROPN B-AC
+, PUNCT O
+area NOUN O
+under ADP O
+the DET O
+receiver NOUN O
+operating VERB O
+characteristic ADJ O
+curve NOUN O
+; PUNCT O
+TG NOUN B-AC
+, PUNCT O
+trigeminal ADJ B-LF
+ganglion NOUN I-LF
+. PUNCT O
+
+DRG PROPN B-AC
+, PUNCT O
+dorsal ADJ B-LF
+root NOUN I-LF
+ganglia NOUN I-LF
+; PUNCT O
+S.C. PROPN O
+, PUNCT O
+spinal ADJ O
+cord NOUN O
+. PUNCT O
+
+GFP PROPN B-AC
+= PUNCT O
+the DET B-LF
+peel NOUN I-LF
+of ADP I-LF
+green ADJ I-LF
+fruit NOUN I-LF
+; PUNCT O
+GFS PROPN B-AC
+= PUNCT O
+the DET B-LF
+sarcocarp NOUN I-LF
+of ADP I-LF
+green ADJ I-LF
+fruit NOUN I-LF
+; PUNCT O
+FP PROPN B-AC
+= PUNCT O
+the DET B-LF
+peel NOUN I-LF
+of ADP I-LF
+red ADJ I-LF
+fruit NOUN I-LF
+; PUNCT O
+FS PROPN B-AC
+= PUNCT O
+the DET B-LF
+sarcocarp NOUN I-LF
+of ADP I-LF
+red ADJ I-LF
+fruit NOUN I-LF
+. PUNCT O
+
+The DET O
+obtained VERB O
+molecular ADJ O
+structure NOUN O
+suggests VERB O
+that SCONJ O
+, PUNCT O
+like ADP O
+its PRON O
+A. PROPN O
+thaliana PROPN O
+ortholog NOUN O
+, PUNCT O
+KDM1 PROPN O
+represents VERB O
+a DET O
+tetrameric ADJ O
+KV NOUN O
+channel NOUN O
+with ADP O
+a DET O
+non ADJ O
+- PUNCT O
+domain NOUN O
+- PUNCT O
+swapped VERB O
+subunit NOUN O
+arrangement NOUN O
+of ADP O
+its PRON O
+voltage NOUN B-LF
+- PUNCT I-LF
+sensing VERB I-LF
+domains NOUN I-LF
+( PUNCT O
+VSDs NOUN B-AC
+; PUNCT O
+S1 NOUN O
+to ADP O
+S4 PROPN O
+) PUNCT O
+and CCONJ O
+a DET O
+central ADJ O
+pore NOUN B-LF
+domain NOUN I-LF
+( PUNCT O
+PD NOUN B-AC
+; PUNCT O
+S5 PROPN O
+- PUNCT O
+P PROPN O
+- PUNCT O
+S6 PROPN O
+) PUNCT O
+, PUNCT O
+followed VERB O
+by ADP O
+a DET O
+“ PUNCT O
+C NOUN O
+- PUNCT O
+linker NOUN O
+” PUNCT O
+helix NOUN O
+and CCONJ O
+a DET O
+pseudo ADJ O
+cyclic ADJ O
+nucleotide NOUN O
+- PUNCT O
+binding VERB O
+domain NOUN O
+[ PUNCT O
+20 NUM O
+] PUNCT O
+. PUNCT O
+
+GCL PROPN O
+, PUNCT O
+ganglion NOUN O
+cell NOUN O
+layer NOUN O
+; PUNCT O
+INL PROPN B-AC
+, PUNCT O
+inner ADJ B-LF
+nuclear ADJ I-LF
+layer NOUN I-LF
+; PUNCT O
+ONL PROPN B-AC
+, PUNCT O
+outer ADJ B-LF
+nuclear ADJ I-LF
+layer NOUN I-LF
+; PUNCT O
+ON PROPN O
+, PUNCT O
+optic ADJ O
+nerve NOUN O
+; PUNCT O
+PZ PROPN O
+, PUNCT O
+proliferative ADJ O
+zone NOUN O
+. PUNCT O
+
+There PRON O
+were VERB O
+no DET O
+significant ADJ O
+differences NOUN O
+in ADP O
+outcome NOUN O
+between ADP O
+the DET O
+azithromycin NOUN O
+group NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+1,096 NUM O
+) PUNCT O
+and CCONJ O
+the DET O
+placebo NOUN O
+group NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+1,087 NUM O
+) PUNCT O
+in ADP O
+respect NOUN O
+of ADP O
+preterm ADJ O
+birth NOUN O
+( PUNCT O
+16.8 NUM O
+% NOUN O
+versus ADP O
+17.4 NUM O
+% NOUN O
+) PUNCT O
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT O
+OR PROPN B-AC
+) PUNCT O
+0.96 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN O
+interval NOUN O
+( PUNCT O
+0.76–1.21 NUM O
+) PUNCT O
+; PUNCT O
+mean ADJ O
+gestational ADJ O
+age NOUN O
+at ADP O
+delivery NOUN O
+( PUNCT O
+38.5 NUM O
+versus ADP O
+38.4 NUM O
+weeks NOUN O
+) PUNCT O
+, PUNCT O
+mean ADJ O
+difference NOUN O
+0.16 NUM O
+( PUNCT O
+−0.08 NUM O
+to PART O
+0.40 NUM O
+) PUNCT O
+; PUNCT O
+mean ADJ O
+birthweight NOUN O
+( PUNCT O
+3.03 NUM O
+versus ADP O
+2.99 NUM O
+kg NOUN O
+) PUNCT O
+, PUNCT O
+mean ADJ O
+difference NOUN O
+0.04 NUM O
+( PUNCT O
+−0.005 NUM O
+to PART O
+0.08 NUM O
+) PUNCT O
+; PUNCT O
+perinatal ADJ O
+deaths NOUN O
+( PUNCT O
+4.3 NUM O
+% NOUN O
+versus ADP O
+5.0 NUM O
+% NOUN O
+) PUNCT O
+, PUNCT O
+OR PROPN B-AC
+0.85 NUM O
+( PUNCT O
+0.53–1.38 NUM O
+) PUNCT O
+; PUNCT O
+or CCONJ O
+maternal ADJ O
+malarial ADJ O
+parasitaemia NOUN O
+( PUNCT O
+11.5 NUM O
+% NOUN O
+versus ADP O
+10.1 NUM O
+% NOUN O
+) PUNCT O
+, PUNCT O
+OR PROPN B-AC
+1.11 NUM O
+( PUNCT O
+0.84–1.49 NUM O
+) PUNCT O
+and CCONJ O
+anaemia NOUN O
+( PUNCT O
+44.1 NUM O
+% NOUN O
+versus ADP O
+41.3 NUM O
+% NOUN O
+) PUNCT O
+at ADP O
+28–32 NUM O
+weeks NOUN O
+, PUNCT O
+OR PROPN B-AC
+1.07 NUM O
+( PUNCT O
+0.88–1.30 NUM O
+) PUNCT O
+. PUNCT O
+
+Environmental ADJ B-LF
+enrichment NOUN I-LF
+significantly ADV O
+increased VERB O
+spatial ADJ O
+coherence NOUN O
+of ADP O
+pyramidal ADJ O
+cells NOUN O
+to ADP O
+0.256 NUM O
+± SYM O
+0.029 NUM O
+( PUNCT O
+p NOUN O
+= SYM O
+0.001 NUM O
+, PUNCT O
+Wald PROPN O
+Chi NOUN O
+- PUNCT O
+Square PROPN O
+8.637 NUM O
+, PUNCT O
+Cohen PROPN O
+’s PART O
+d NOUN O
+0.41 NUM O
+; PUNCT O
+MAM PROPN O
+- PUNCT O
+E PROPN O
+compared VERB O
+to ADP O
+MAM PROPN O
+unenriched ADJ O
+) PUNCT O
+, PUNCT O
+consistent ADJ O
+with ADP O
+our PRON O
+prior ADJ O
+findings NOUN O
+that SCONJ O
+EE PROPN B-AC
+significantly ADV O
+improves VERB O
+spatial ADJ O
+learning NOUN O
+and CCONJ O
+memory NOUN O
+. PUNCT O
+
+BMDM PROPN B-AC
+, PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+– PUNCT I-LF
+derived VERB I-LF
+MΦ PROPN I-LF
+; PUNCT O
+CFU PROPN O
+, PUNCT O
+colony NOUN O
+forming VERB O
+unit NOUN O
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+HS PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+salt NOUN I-LF
+; PUNCT O
+LPS PROPN B-AC
+, PUNCT O
+lipopolysaccharide NOUN B-LF
+; PUNCT O
+mLC3 PROPN B-AC
+, PUNCT O
+microtubule NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+light NOUN I-LF
+chain NOUN I-LF
+3 NUM I-LF
+; PUNCT O
+MΦ PROPN B-AC
+, PUNCT O
+monocyte NOUN B-LF
+/ SYM I-LF
+macrophage NOUN I-LF
+- PUNCT I-LF
+like ADJ I-LF
+cell NOUN I-LF
+; PUNCT O
+NFAT5 PROPN B-AC
+, PUNCT O
+nuclear ADJ B-LF
+factor NOUN I-LF
+of ADP I-LF
+activated VERB I-LF
+T PROPN I-LF
+cells NOUN I-LF
+5 NUM I-LF
+; PUNCT O
+Nos2 PROPN O
+, PUNCT O
+nitric NOUN O
+oxide NOUN O
+synthase NOUN O
+2 NUM O
+; PUNCT O
+NS PROPN B-AC
+, PUNCT O
+normal ADJ B-LF
+salt NOUN I-LF
+; PUNCT O
+ns PROPN B-AC
+, PUNCT O
+nonsilencing NOUN B-LF
+; PUNCT O
+n.s PROPN O
+. PUNCT O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+RFP PROPN B-AC
+, PUNCT O
+red ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+siRNA PROPN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+; PUNCT O
+Slc8 PROPN O
+, PUNCT O
+solute NOUN O
+carrier NOUN O
+family NOUN O
+8 NUM O
+. PUNCT O
+
+We PRON O
+have AUX O
+also ADV O
+developed VERB O
+matrix NOUN B-LF
+- PUNCT I-LF
+assisted VERB I-LF
+laser NOUN I-LF
+desorption NOUN I-LF
+/ SYM I-LF
+ionisation NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT O
+MALDI PROPN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+) PUNCT O
+assays NOUN O
+for ADP O
+high ADJ O
+- PUNCT O
+throughput NOUN O
+epigenotyping NOUN O
+of ADP O
+the DET O
+analysed VERB O
+regions NOUN O
+. PUNCT O
+
+LRR PROPN B-AC
+, PUNCT O
+leucine NOUN B-LF
+- PUNCT I-LF
+rich ADJ I-LF
+repeat NOUN I-LF
+. PUNCT O
+
+The DET O
+suspension NOUN B-LF
+glycan NOUN I-LF
+array NOUN I-LF
+( PUNCT O
+SGA PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+multiplex ADJ O
+analysis NOUN O
+system NOUN O
+permitting VERB O
+the DET O
+simultaneous ADJ O
+analysis NOUN O
+of ADP O
+multiple ADJ O
+different ADJ O
+biomolecules NOUN O
+and CCONJ O
+includes VERB O
+( PUNCT O
+i X O
+) PUNCT O
+the DET O
+production NOUN O
+of ADP O
+glycopolymers NOUN O
+composed VERB O
+of ADP O
+a DET O
+polyacrylamide NOUN O
+carrier NOUN O
+provided VERB O
+with ADP O
+end NOUN O
+biotin NOUN O
+groups NOUN O
+and CCONJ O
+side NOUN O
+- PUNCT O
+pendant NOUN O
+glycan NOUN O
+residues NOUN O
+chemically ADV O
+synthesized VERB O
+or CCONJ O
+purchased VERB O
+, PUNCT O
+( PUNCT O
+ii X O
+) PUNCT O
+the DET O
+coupling NOUN O
+of ADP O
+these DET O
+glycopolymers NOUN O
+to ADP O
+fluorescent ADJ O
+microbeads NOUN O
+, PUNCT O
+( PUNCT O
+iii X O
+) PUNCT O
+the DET O
+incubation NOUN O
+of ADP O
+these DET O
+beads NOUN O
+with ADP O
+serum NOUN O
+samples NOUN O
+, PUNCT O
+and CCONJ O
+( PUNCT O
+iv X O
+) PUNCT O
+the DET O
+measurement NOUN O
+of ADP O
+the DET O
+AGA PROPN B-AC
+hybridized VERB O
+to ADP O
+the DET O
+glycopolymers NOUN O
+( PUNCT O
+“ PUNCT O
+binding VERB O
+” PUNCT O
+) PUNCT O
+using VERB O
+fluorescently ADV O
+labelled VERB O
+reporter NOUN O
+molecules NOUN O
+( PUNCT O
+secondary ADJ O
+antibodies NOUN O
+) PUNCT O
+specific ADJ O
+for ADP O
+each DET O
+AGA PROPN B-AC
+with ADP O
+subsequent ADJ O
+data NOUN O
+analysis NOUN O
+. PUNCT O
+
+Methylation NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+PCR NOUN I-LF
+, PUNCT O
+while SCONJ O
+robust ADJ O
+, PUNCT O
+is AUX O
+extremely ADV O
+sensitive ADJ O
+and CCONJ O
+can AUX O
+detect VERB O
+methylated VERB O
+sequences NOUN O
+in ADP O
+the DET O
+presence NOUN O
+of ADP O
+large ADJ O
+amounts NOUN O
+of ADP O
+unmethylated VERB O
+DNA NOUN O
+. PUNCT O
+We PRON O
+used VERB O
+sodium NOUN O
+bisulfite NOUN O
+DNA NOUN O
+sequencing NOUN O
+to PART O
+confirm VERB O
+that SCONJ O
+the DET O
+MSP PROPN B-AC
+primer NOUN O
+sets NOUN O
+used VERB O
+in ADP O
+these DET O
+studies NOUN O
+amplified VERB O
+the DET O
+appropriate ADJ O
+target NOUN O
+sequences NOUN O
+and CCONJ O
+that SCONJ O
+these DET O
+sites NOUN O
+were AUX O
+bona ADJ O
+fide ADJ O
+hypermethylated ADJ O
+CpG NOUN O
+islands NOUN O
+. PUNCT O
+
+C PROPN O
+, PUNCT O
+CFP PROPN B-AC
+tag NOUN O
+; PUNCT O
+CC1 PROPN B-AC
+, PUNCT O
+coiled NOUN B-LF
+- PUNCT I-LF
+coil NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+CFP PROPN B-AC
+, PUNCT O
+cyan NOUN B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+; PUNCT O
+EF NOUN B-AC
+- PUNCT B-AC
+SAM PROPN B-AC
+, PUNCT O
+EF NOUN B-LF
+- PUNCT I-LF
+hand NOUN I-LF
+and CCONJ I-LF
+sterile ADJ I-LF
+alpha NOUN I-LF
+motif NOUN I-LF
+domain NOUN I-LF
+; PUNCT O
+K PROPN O
+, PUNCT O
+lysine NOUN O
+- PUNCT O
+rich ADJ O
+region NOUN O
+; PUNCT O
+NT PROPN B-AC
+, PUNCT O
+N PROPN B-LF
+terminus NOUN I-LF
+; PUNCT O
+PM PROPN B-AC
+, PUNCT O
+plasma NOUN B-LF
+membrane NOUN I-LF
+; PUNCT O
+SC PROPN B-AC
+, PUNCT O
+STIM1 PROPN B-LF
+- PUNCT I-LF
+CC1 PROPN I-LF
+construct NOUN I-LF
+; PUNCT O
+SOAR PROPN B-AC
+, PUNCT O
+STIM PROPN B-LF
+- PUNCT I-LF
+Orai NOUN I-LF
+– PUNCT I-LF
+activating VERB I-LF
+region NOUN I-LF
+; PUNCT O
+SOAR1L PROPN O
+, PUNCT O
+STIM1(343–491 NUM O
+) PUNCT O
+; PUNCT O
+STIM PROPN B-AC
+, PUNCT O
+stromal NOUN B-LF
+interaction NOUN I-LF
+molecule NOUN I-LF
+; PUNCT O
+sα1–4 NOUN O
+: PUNCT O
+α NOUN O
+helix NOUN O
+1 NUM O
+to PART O
+4 NUM O
+of ADP O
+SOAR PROPN B-AC
+region NOUN O
+; PUNCT O
+TM PROPN B-AC
+, PUNCT O
+transmembrane NOUN B-LF
+region NOUN I-LF
+; PUNCT O
+Y PROPN O
+, PUNCT O
+YFP PROPN B-AC
+tag NOUN O
+; PUNCT O
+YFP PROPN B-AC
+, PUNCT O
+yellow ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+. PUNCT O
+
+HDV PROPN B-AC
+, PUNCT O
+Hepatitis PROPN B-LF
+Delta PROPN I-LF
+Virus PROPN I-LF
+. PUNCT O
+
+Herein ADV O
+, PUNCT O
+we PRON O
+build VERB O
+up ADP O
+a DET O
+unique ADJ O
+system NOUN O
+, PUNCT O
+namely ADV O
+liquid NOUN B-LF
+chromatography NOUN I-LF
+gel NOUN B-LF
+electrophoresis NOUN I-LF
+inductively ADV B-LF
+coupled VERB I-LF
+plasma NOUN I-LF
+mass NOUN I-LF
+spectrometry NOUN I-LF
+( PUNCT O
+LC PROPN B-AC
+- PUNCT O
+GE PROPN B-AC
+- PUNCT O
+ICP NOUN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+) PUNCT O
+, PUNCT O
+allowing VERB O
+34 NUM O
+proteins NOUN O
+directly ADV O
+bound VERB O
+by ADP O
+silver NOUN O
+ions NOUN O
+to PART O
+be AUX O
+identified VERB O
+in ADP O
+Escherichia PROPN O
+coli PROPN O
+. PUNCT O
+
+In ADP O
+mammals NOUN O
+( PUNCT O
+upper ADJ O
+pathway NOUN O
+) PUNCT O
+, PUNCT O
+electrons NOUN O
+from ADP O
+NADPH PROPN O
+are AUX O
+transferred VERB O
+to ADP O
+an DET O
+oxidoreductase NOUN O
+flavoenzyme NOUN O
+, PUNCT O
+either CCONJ O
+thioredoxin NOUN B-LF
+reductase NOUN I-LF
+( PUNCT O
+TrxR PROPN B-AC
+) PUNCT O
+or CCONJ O
+glutathione NOUN B-LF
+reductase NOUN I-LF
+( PUNCT O
+GR PROPN B-AC
+) PUNCT O
+. PUNCT O
+Electrons NOUN O
+are AUX O
+then ADV O
+transferred VERB O
+from ADP O
+the DET O
+oxidoreductase NOUN O
+flavoenzyme NOUN O
+to ADP O
+the DET O
+appropriate ADJ O
+electron NOUN O
+carrier NOUN O
+, PUNCT O
+either CCONJ O
+oxidized VERB O
+thioredoxin NOUN B-LF
+( PUNCT O
+Trx PROPN B-AC
+- PUNCT O
+S2 PROPN O
+) PUNCT O
+or CCONJ O
+glutathione NOUN B-LF
+disulfide NOUN I-LF
+( PUNCT O
+GSSG PROPN B-AC
+) PUNCT O
+converting VERB O
+them PRON O
+to ADP O
+reduced VERB O
+thioredoxin NOUN B-LF
+( PUNCT O
+Trx-[SH]2 PROPN B-AC
+) PUNCT O
+or CCONJ O
+glutathione NOUN B-LF
+( PUNCT O
+GSH PROPN B-AC
+) PUNCT O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+Tuberculosis NOUN B-LF
+( PUNCT O
+TB PROPN B-AC
+) PUNCT O
+remains VERB O
+as ADP O
+one NUM O
+of ADP O
+the DET O
+main ADJ O
+causes NOUN O
+of ADP O
+deaths NOUN O
+among ADP O
+people NOUN B-LF
+living VERB I-LF
+with ADP I-LF
+HIV PROPN I-LF
+( PUNCT O
+PLHIV PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+We PRON O
+observed VERB O
+32 NUM O
+sequence NOUN B-LF
+types NOUN I-LF
+( PUNCT O
+STs NOUN B-AC
+) PUNCT O
+among ADP O
+the DET O
+132 NUM O
+Bordetella PROPN O
+isolates NOUN O
+. PUNCT O
+
+BC PROPN B-AC
+, PUNCT O
+breast NOUN B-LF
+cancer NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+HDL NOUN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+IVW NOUN O
+, PUNCT O
+inverse NOUN O
+- PUNCT O
+variance NOUN O
+weighted VERB O
+; PUNCT O
+LDL NOUN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+MR NOUN B-AC
+, PUNCT O
+Mendelian ADJ B-LF
+randomization NOUN I-LF
+; PUNCT O
+MVP PROPN B-AC
+, PUNCT O
+Million PROPN B-LF
+Veteran PROPN I-LF
+Program PROPN I-LF
+; PUNCT O
+OR NOUN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+TC NOUN B-AC
+, PUNCT O
+total ADJ B-LF
+cholesterol NOUN I-LF
+; PUNCT O
+TG NOUN B-AC
+, PUNCT O
+triglyceride NOUN B-LF
+. PUNCT O
+
+PMI PROPN B-AC
+, PUNCT O
+President PROPN B-LF
+’s PART I-LF
+Malaria PROPN I-LF
+Initiative PROPN I-LF
+. PUNCT O
+
+However ADV O
+, PUNCT O
+no DET O
+labeled VERB O
+cells NOUN O
+were AUX O
+observed VERB O
+in ADP O
+TRPV1 PROPN B-AC
+knock VERB B-LF
+- PUNCT I-LF
+out NOUN I-LF
+( PUNCT O
+KO PROPN B-AC
+) PUNCT O
+mice NOUN O
+( PUNCT O
+Fig PROPN O
+1B NUM O
+) PUNCT O
+. PUNCT O
+Additionally ADV O
+, PUNCT O
+western ADJ O
+blot NOUN O
+analysis NOUN O
+showed VERB O
+a DET O
+TRPV1 PROPN B-AC
+- PUNCT O
+positive ADJ O
+signal NOUN O
+in ADP O
+lysates NOUN O
+from ADP O
+the DET O
+ARC PROPN B-AC
+of ADP O
+control NOUN O
+but CCONJ O
+not PART O
+TRPV1 PROPN B-AC
+KO PROPN B-AC
+mice NOUN O
+( PUNCT O
+Fig PROPN O
+1C NUM O
+) PUNCT O
+. PUNCT O
+Importantly ADV O
+, PUNCT O
+immunostaining NOUN O
+, PUNCT O
+quantitative ADJ B-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+qPCR PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+western ADJ O
+blot NOUN O
+analysis NOUN O
+showed VERB O
+no DET O
+expression NOUN O
+of ADP O
+TRPV1 PROPN B-AC
+receptors NOUN O
+around ADP O
+the DET O
+ARC PROPN B-AC
+( PUNCT O
+S4B PROPN O
+, PUNCT O
+S4C PROPN O
+and CCONJ O
+S4D PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+CAM PROPN B-AC
+, PUNCT O
+CamK2a PROPN B-LF
+; PUNCT O
+NS PROPN O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+P PROPN O
+, PUNCT O
+postnatal ADJ O
+day NOUN O
+; PUNCT O
+USP PROPN B-AC
+, PUNCT O
+ubiquitin NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+protease NOUN I-LF
+; PUNCT O
+USV PROPN B-AC
+, PUNCT O
+ultrasonic ADJ B-LF
+vocalization NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+A DET O
+significant ADJ O
+minority NOUN O
+( PUNCT O
+around ADV O
+3 NUM O
+% NOUN O
+) PUNCT O
+of ADP O
+EC PROPN B-AC
+are AUX O
+caused VERB O
+by ADP O
+an DET O
+inherited VERB O
+genetic ADJ O
+predisposition NOUN O
+called VERB O
+Lynch PROPN B-LF
+syndrome NOUN I-LF
+( PUNCT O
+LS PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+SES PROPN B-AC
+, PUNCT O
+socioeconomic ADJ B-LF
+status NOUN I-LF
+. PUNCT O
+
+BC PROPN B-AC
+, PUNCT O
+betweenness NOUN B-LF
+centrality NOUN I-LF
+. PUNCT O
+
+Please INTJ O
+see VERB O
+page NOUN O
+12 NUM O
+, PUNCT O
+Methods NOUN O
+/ SYM O
+Outcome NOUN O
+measures NOUN O
+: PUNCT O
+Lines NOUN O
+243 NUM O
+- PUNCT O
+246 NUM O
+“ PUNCT O
+The DET O
+primary ADJ O
+outcome NOUN O
+of ADP O
+interest NOUN O
+was AUX O
+ICU PROPN B-AC
+- PUNCT B-AC
+LOS PROPN B-AC
+. PUNCT O
+Secondary ADJ O
+outcomes NOUN O
+included VERB O
+PaO2 NOUN B-AC
+, PUNCT O
+the DET O
+ratio NOUN O
+of ADP O
+the DET O
+partial ADJ B-LF
+pressure NOUN I-LF
+of ADP I-LF
+arterial ADJ I-LF
+oxygen NOUN I-LF
+and CCONJ O
+fraction NOUN B-LF
+of ADP I-LF
+inspired ADJ I-LF
+oxygen NOUN I-LF
+( PUNCT O
+PaO2 NOUN B-AC
+/ SYM O
+FiO2 NOUN B-AC
+) PUNCT O
+, PUNCT O
+PaCO2 NOUN B-AC
+, PUNCT O
+airway NOUN O
+clearance NOUN O
+, PUNCT O
+the DET O
+incidence NOUN O
+of ADP O
+pneumonia NOUN O
+, PUNCT O
+respiratory ADJ O
+rate NOUN O
+, PUNCT O
+and CCONJ O
+pulmonary ADJ O
+atelectasis NOUN O
+. PUNCT O
+” PUNCT O
+
+GLP-1 NOUN B-AC
+, PUNCT O
+glucagon NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+peptide NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+PYY3 NOUN B-AC
+- PUNCT B-AC
+36 NUM B-AC
+, PUNCT O
+peptide NOUN B-LF
+YY3 NOUN I-LF
+- PUNCT I-LF
+36 NUM I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+cCBT PROPN B-AC
+, PUNCT O
+computerised ADJ B-LF
+cognitive ADJ I-LF
+- PUNCT I-LF
+behaviour NOUN I-LF
+therapy NOUN I-LF
+; PUNCT O
+OCD PROPN B-AC
+, PUNCT O
+obsessive ADJ B-LF
+- PUNCT I-LF
+compulsive ADJ I-LF
+disorder NOUN I-LF
+. PUNCT O
+
+IR PROPN B-AC
+, PUNCT O
+ionotropic ADJ B-LF
+receptor NOUN I-LF
+; PUNCT O
+qPCR NOUN B-AC
+, PUNCT O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+. PUNCT O
+
+BP PROPN B-AC
+, PUNCT O
+blood NOUN B-LF
+pressure NOUN I-LF
+; PUNCT O
+CARDIoGRAMplusC4D PROPN B-AC
+, PUNCT O
+Coronary PROPN B-LF
+ARtery PROPN I-LF
+DIsease PROPN I-LF
+Genome PROPN I-LF
+wide ADJ I-LF
+Replication PROPN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PUNCT I-LF
+analysis PROPN I-LF
+( PUNCT I-LF
+CARDIoGRAM PROPN I-LF
+) PUNCT I-LF
+plus CCONJ I-LF
+The DET I-LF
+Coronary PROPN I-LF
+Artery PROPN I-LF
+Disease PROPN I-LF
+( PUNCT I-LF
+C4D PROPN I-LF
+) PUNCT I-LF
+Genetics PROPN I-LF
+consortium NOUN I-LF
+; PUNCT O
+FDR PROPN B-AC
+, PUNCT O
+false ADJ B-LF
+discovery NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+GLGC PROPN B-AC
+, PUNCT O
+Global PROPN B-LF
+Lipids PROPN I-LF
+Genetic PROPN I-LF
+Consortium PROPN I-LF
+; PUNCT O
+GRS PROPN B-AC
+, PUNCT O
+polygenic ADJ B-LF
+risk NOUN I-LF
+score NOUN I-LF
+; PUNCT O
+GUGC PROPN B-AC
+, PUNCT O
+Global PROPN O
+Urate PROPN O
+Genetic PROPN O
+Consortium PROPN O
+; PUNCT O
+GWAS PROPN B-AC
+, PUNCT O
+genome NOUN B-LF
+- PUNCT I-LF
+wide ADJ I-LF
+association NOUN I-LF
+study NOUN I-LF
+; PUNCT O
+ICBP PROPN B-AC
+, PUNCT O
+International PROPN B-LF
+Consortium PROPN I-LF
+for ADP I-LF
+Blood PROPN I-LF
+Pressure PROPN I-LF
+; PUNCT O
+ISGC PROPN B-AC
+, PUNCT O
+Ischaemic PROPN B-LF
+stroke NOUN I-LF
+Genetic PROPN I-LF
+Consortium PROPN I-LF
+; PUNCT O
+MR PROPN B-AC
+IVW PROPN B-AC
+, PUNCT O
+inverse ADJ B-LF
+variance NOUN I-LF
+weighted VERB I-LF
+mendelian ADJ I-LF
+randomization NOUN I-LF
+; PUNCT O
+MR PROPN B-AC
+- PUNCT B-AC
+MoE PROPN B-AC
+, PUNCT O
+a DET B-LF
+mixture NOUN I-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+experts NOUN I-LF
+machine NOUN I-LF
+learning NOUN I-LF
+framework NOUN I-LF
+of ADP I-LF
+mendelian ADJ I-LF
+randomization NOUN I-LF
+; PUNCT O
+PheWAS PROPN B-AC
+, PUNCT O
+phenome NOUN B-LF
+- PUNCT I-LF
+wide ADJ I-LF
+association NOUN I-LF
+study NOUN I-LF
+; PUNCT O
+PP PROPN B-AC
+, PUNCT O
+posterior ADJ B-LF
+probability NOUN I-LF
+; PUNCT O
+TreeWAS PROPN B-AC
+, PUNCT O
+tree NOUN B-LF
+- PUNCT I-LF
+structured ADJ I-LF
+phenotypic ADJ I-LF
+model NOUN I-LF
+. PUNCT O
+
+Alternatively ADV O
+, PUNCT O
+we PRON O
+transiently ADV O
+expressed VERB O
+35S PROPN O
+: PROPN O
+FTIP1 PROPN B-AC
+: PROPN O
+GFP PROPN B-AC
+with ADP O
+various ADJ O
+fluorescent ADJ O
+protein NOUN O
+- PUNCT O
+tagged VERB O
+organelle NOUN O
+markers NOUN O
+in ADP O
+N. PROPN O
+benthamiana PROPN O
+leaf NOUN O
+epidermal ADJ O
+cells NOUN O
+and CCONJ O
+found VERB O
+that SCONJ O
+FTIP1 PROPN B-AC
+: PROPN O
+GFP PROPN B-AC
+was AUX O
+mostly ADV O
+colocalized VERB O
+with ADP O
+an DET O
+endoplasmic ADJ B-LF
+reticulum NOUN I-LF
+( PUNCT O
+ER PROPN B-AC
+) PUNCT O
+marker NOUN O
+( PUNCT O
+Figure NOUN O
+3B NUM O
+, PUNCT O
+C NOUN O
+; PUNCT O
+Figure NOUN O
+S6 NOUN O
+) PUNCT O
+[ PUNCT O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+Robust ADJ O
+LTP NOUN B-AC
+of ADP O
+excitatory ADJ O
+synaptic ADJ O
+transmission NOUN O
+could AUX O
+be AUX O
+evoked VERB O
+by ADP O
+high ADJ B-LF
+- PUNCT I-LF
+frequency NOUN I-LF
+stimulations NOUN I-LF
+( PUNCT O
+HFS PROPN B-AC
+: PUNCT O
+four NUM O
+trains NOUN O
+of ADP O
+100 NUM O
+stimuli NOUN O
+at ADP O
+100 NUM O
+Hz NOUN O
+) PUNCT O
+in ADP O
+WT PROPN B-AC
+animals NOUN O
+. PUNCT O
+
+A PROPN O
+, PUNCT O
+aphidicolin NOUN O
+; PUNCT O
+DRAQ5 PROPN O
+, PUNCT O
+deep ADJ O
+red ADJ O
+anthraquinone NOUN O
+5 NUM O
+; PUNCT O
+hdac1 PROPN B-AC
+, PUNCT O
+histone NOUN B-LF
+- PUNCT I-LF
+deacetylase NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+hpf NOUN B-AC
+, PUNCT O
+hours NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+; PUNCT O
+HU PROPN O
+, PUNCT O
+hydroxyurea NOUN O
+; PUNCT O
+n.s PROPN O
+. PUNCT O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+PSE PROPN B-AC
+, PUNCT O
+pseudostratified ADJ B-LF
+epithelium NOUN I-LF
+. PUNCT O
+
+N1+/-;N2+/- NOUN B-AC
+, PUNCT O
+Notch1 PROPN B-LF
+/ SYM O
+Notch2 PROPN B-LF
+RA NOUN O
+hemizygous ADJ O
+; PUNCT O
+N2RA PROPN B-AC
+/ SYM O
+RA NOUN O
+, PUNCT O
+Notch2 PROPN B-LF
+RA NOUN O
+homozygous ADJ O
+; PUNCT O
+P0 NOUN O
+- PUNCT O
+1 NUM O
+, PUNCT O
+postnatal ADJ O
+day NOUN O
+0–1 NUM O
+; PUNCT O
+RA NOUN O
+, PUNCT O
+Arg PROPN O
+( PUNCT O
+N1R1974 PROPN O
+/ SYM O
+N2R1934 PROPN O
+) PUNCT O
+to ADP O
+Ala PROPN O
+substitution NOUN O
+; PUNCT O
+wt NOUN O
+, PUNCT O
+wild ADJ O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+R NOUN O
+: PUNCT O
+Reproductive ADJ O
+number NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+, PUNCT O
+95 NUM O
+% NOUN O
+Confidence NOUN B-LF
+Interval NOUN I-LF
+. PUNCT O
+
+Molecular ADJ O
+confirmation NOUN O
+of ADP O
+the DET O
+role NOUN O
+of ADP O
+Fyn PROPN O
+and CCONJ O
+c NOUN O
+- PUNCT O
+Cbl NOUN O
+in ADP O
+the DET O
+effects NOUN O
+of ADP O
+MeHg PROPN B-AC
+on ADP O
+levels NOUN O
+of ADP O
+PDGFRα PROPN B-AC
+was AUX O
+obtained VERB O
+by ADP O
+expression NOUN O
+of ADP O
+dominant ADJ O
+negative ADJ O
+c NOUN O
+- PUNCT O
+Cbl NOUN O
+, PUNCT O
+or CCONJ O
+small ADJ O
+inhibitory ADJ B-LF
+RNA NOUN I-LF
+( PUNCT O
+RNAi NOUN B-AC
+) PUNCT O
+for ADP O
+Fyn PROPN O
+or CCONJ O
+Cbl NOUN O
+, PUNCT O
+in ADP O
+MeHg PROPN B-AC
+- PUNCT O
+exposed VERB O
+O-2A NOUN B-AC
+/ SYM B-AC
+OPCs NOUN O
+. PUNCT O
+Expression NOUN O
+of ADP O
+the DET O
+dominant ADJ O
+- PUNCT O
+negative ADJ O
+( PUNCT O
+DN PROPN O
+) PUNCT O
+70z NOUN O
+mutant NOUN O
+of ADP O
+c NOUN O
+- PUNCT O
+Cbl NOUN O
+[ X O
+106–108 NUM O
+] X O
+in ADP O
+O-2A NOUN B-AC
+/ SYM B-AC
+OPCs NOUN O
+prevented VERB O
+MeHg PROPN B-AC
+- PUNCT O
+induced VERB O
+reductions NOUN O
+in ADP O
+levels NOUN O
+of ADP O
+PDGFRα PROPN B-AC
+( PUNCT O
+Figure NOUN O
+6A NUM O
+) PUNCT O
+. PUNCT O
+Reduction NOUN O
+in ADP O
+levels NOUN O
+of ADP O
+Fyn PROPN O
+protein NOUN O
+by ADP O
+introduction NOUN O
+of ADP O
+Fyn PROPN O
+- PUNCT O
+specific ADJ O
+small ADJ B-LF
+interfering ADJ I-LF
+RNA NOUN I-LF
+( PUNCT O
+siRNA NOUN B-AC
+) PUNCT O
+constructs NOUN O
+( PUNCT O
+Figure NOUN O
+6B NUM O
+) PUNCT O
+also ADV O
+protected VERB O
+against ADP O
+MeHg PROPN B-AC
+- PUNCT O
+induced VERB O
+reductions NOUN O
+in ADP O
+levels NOUN O
+of ADP O
+PDGFRα PROPN B-AC
+( PUNCT O
+Figure NOUN O
+6C NUM O
+) PUNCT O
+, PUNCT O
+as SCONJ O
+predicted VERB O
+by ADP O
+the DET O
+hypothesis NOUN O
+that SCONJ O
+MeHg PROPN B-AC
+- PUNCT O
+induced VERB O
+activation NOUN O
+of ADP O
+Fyn PROPN O
+mechanistically ADV O
+precedes VERB O
+reductions NOUN O
+in ADP O
+receptor NOUN O
+levels NOUN O
+. PUNCT O
+
+Data PROPN O
+are AUX O
+included VERB O
+in ADP O
+S2 PROPN O
+Data PROPN O
+. PUNCT O
+4HNE NOUN B-AC
+, PUNCT O
+4 NUM B-LF
+- PUNCT I-LF
+hydroxynonenal NOUN I-LF
+; PUNCT O
+BMDM PROPN B-AC
+, PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+– PUNCT I-LF
+derived VERB I-LF
+macrophage NOUN I-LF
+; PUNCT O
+LPS PROPN B-AC
+, PUNCT O
+lipopolysaccharides NOUN B-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+qPCR NOUN B-AC
+, PUNCT O
+reverse ADJ B-LF
+transcriptase NOUN I-LF
+quantitative ADJ I-LF
+PCR NOUN I-LF
+. PUNCT O
+
+Matching PROPN O
+Methods NOUN O
+: PUNCT O
+What PRON O
+the DET O
+aim NOUN O
+of ADP O
+taking VERB O
+into ADP O
+account NOUN O
+the DET O
+" PUNCT O
+similar ADJ O
+defined VERB B-LF
+daily ADJ I-LF
+dose NOUN I-LF
+( PUNCT O
+DDD)-prescription NOUN B-AC
+of ADP O
+the DET O
+studied VERB O
+drug NOUN O
+" PUNCT O
+for ADP O
+identifying VERB O
+controls NOUN O
+? PUNCT O
+
+Next PROPN B-LF
+Generation PROPN I-LF
+Sequencing PROPN I-LF
+( PUNCT O
+NGS PROPN B-AC
+) PUNCT O
+libraries NOUN O
+were AUX O
+prepared VERB O
+and CCONJ O
+polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+PCR)/reverse NOUN B-AC
+transcription NOUN O
+- PUNCT O
+PCR NOUN B-AC
+( PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+) PUNCT O
+were AUX O
+performed VERB O
+within ADP O
+7 NUM O
+days NOUN O
+. PUNCT O
+
+Small ADJ B-LF
+bowel NOUN I-LF
+adenocarcinoma NOUN I-LF
+( PUNCT O
+SBA PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+malignant ADJ O
+tumor NOUN O
+of ADP O
+the DET O
+small ADJ O
+intestine NOUN O
+mucosa NOUN O
+that PRON O
+is AUX O
+mostly ADV O
+located VERB O
+around ADP O
+the DET O
+duodenal ADJ O
+papilla NOUN O
+. PUNCT O
+
+CAD NOUN B-AC
+= PUNCT O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+, PUNCT O
+HR NOUN B-AC
+= PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+, PUNCT O
+95%CI NOUN B-AC
+= PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+, PUNCT O
+MI NOUN B-AC
+= PUNCT O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+, PUNCT O
+HF NOUN B-AC
+= PUNCT O
+heart NOUN B-LF
+failure NOUN I-LF
+. PUNCT O
+
+Mean ADJ O
+age NOUN O
+of ADP O
+participants NOUN O
+was AUX O
+56.3 NUM O
+years NOUN O
+( PUNCT O
+Standard PROPN B-LF
+Deviation PROPN I-LF
+( PUNCT O
+SD PROPN B-AC
+) PUNCT O
+= SYM O
+11.5 NUM O
+) PUNCT O
+, PUNCT O
+which PRON O
+ranges VERB O
+between ADP O
+30–86 NUM O
+years NOUN O
+. PUNCT O
+
+PE PROPN B-AC
+is AUX O
+also ADV O
+frequently ADV O
+co ADJ O
+- ADJ O
+morbid ADJ O
+with ADP O
+other ADJ O
+conditions NOUN O
+such ADJ O
+as ADP O
+intra ADJ B-LF
+- ADJ I-LF
+uterine ADJ I-LF
+growth NOUN I-LF
+restriction NOUN I-LF
+( PUNCT O
+IUGR PROPN B-AC
+) PUNCT O
+or CCONJ O
+small ADJ B-LF
+- ADJ I-LF
+for ADP I-LF
+- ADJ I-LF
+gestational ADJ I-LF
+age NOUN I-LF
+( PUNCT O
+SGA PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+symptoms NOUN O
+can AUX O
+often ADV O
+“ PUNCT O
+mimic VERB O
+” PUNCT O
+, PUNCT O
+or CCONJ O
+overlap VERB O
+, PUNCT O
+with ADP O
+those PRON O
+of ADP O
+other ADJ O
+syndromes NOUN O
+such ADJ O
+as ADP O
+HELPP PROPN O
+syndrome NOUN O
+— PUNCT O
+making VERB O
+diagnosis NOUN O
+a DET O
+distinctly ADV O
+non ADJ O
+- ADJ O
+trivial ADJ O
+matter NOUN O
+[ PUNCT O
+13 NUM O
+] PUNCT O
+. PUNCT O
+
+Several ADJ O
+professional ADJ O
+societies NOUN O
+, PUNCT O
+including VERB O
+AAGL PROPN B-AC
+( PUNCT O
+Elevating PROPN B-LF
+Gynecologic PROPN I-LF
+Surgery PROPN I-LF
+, PUNCT I-LF
+founded VERB I-LF
+as ADP I-LF
+American PROPN I-LF
+Association PROPN I-LF
+of ADP I-LF
+Gynecologic PROPN I-LF
+Laparoscopists PROPN I-LF
+) PUNCT O
+and CCONJ O
+American PROPN B-LF
+College PROPN I-LF
+of ADP I-LF
+Obstetricians PROPN I-LF
+and CCONJ I-LF
+Gynecologists PROPN I-LF
+( PUNCT O
+ACOG PROPN B-AC
+) PUNCT O
+, PUNCT O
+subsequently ADV O
+followed VERB O
+up ADP O
+with ADP O
+practice NOUN O
+guidelines NOUN O
+and CCONJ O
+committee NOUN O
+opinions NOUN O
+to PART O
+address VERB O
+this DET O
+issue NOUN O
+, PUNCT O
+along ADP O
+with ADP O
+updates NOUN O
+in ADP O
+the DET O
+literature NOUN O
+[ PUNCT O
+9 NUM O
+, PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+Conditional ADJ O
+logistic ADJ O
+regression NOUN O
+was AUX O
+used VERB O
+, PUNCT O
+adjusting VERB O
+for ADP O
+major ADJ O
+risk NOUN O
+factors NOUN O
+for ADP O
+GDM PROPN B-AC
+. PUNCT O
+After ADP O
+adjusting VERB O
+for ADP O
+covariates NOUN O
+, PUNCT O
+individual ADJ O
+n-3 NOUN O
+eicosapentaenoic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+EPA PROPN B-AC
+) PUNCT O
+, PUNCT O
+docosapentaenoic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+DPA PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+docosahexaenoic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+DHA PROPN B-AC
+) PUNCT O
+were AUX O
+inversely ADV O
+correlated VERB O
+with ADP O
+insulin NOUN O
+- PUNCT O
+resistance NOUN O
+markers NOUN O
+, PUNCT O
+whereas SCONJ O
+individual ADJ O
+n-6 NOUN O
+dihomo NOUN B-LF
+- PUNCT I-LF
+gamma NOUN I-LF
+- PUNCT I-LF
+linolenic NOUN I-LF
+acid NOUN I-LF
+( PUNCT O
+DGLA PROPN B-AC
+) PUNCT O
+was AUX O
+positively ADV O
+correlated VERB O
+with ADP O
+insulin NOUN O
+- PUNCT O
+resistance NOUN O
+markers NOUN O
+. PUNCT O
+
+DNL PROPN B-AC
+, PUNCT O
+de X B-LF
+novo X I-LF
+lipogenesis NOUN I-LF
+. PUNCT O
+
+The DET O
+air NOUN O
+pollution NOUN O
+data NOUN O
+was AUX O
+obtained VERB O
+from ADP O
+UK PROPN O
+’s PART O
+Department PROPN B-LF
+for ADP I-LF
+Environment PROPN I-LF
+, PUNCT I-LF
+Food PROPN I-LF
+and CCONJ I-LF
+Rural PROPN I-LF
+Affairs PROPN I-LF
+( PUNCT O
+DEFRA PROPN B-AC
+) PUNCT O
+and CCONJ O
+is AUX O
+freely ADV O
+available ADJ O
+from ADP O
+their PRON O
+website NOUN O
+at ADP O
+https://uk-air.defra.gov.uk/data/pcm-data X O
+. PUNCT O
+
+ADAR1 PROPN B-AC
+still ADV O
+edits VERB O
+some PRON O
+of ADP O
+it PRON O
+( PUNCT O
+blue ADJ O
+) PUNCT O
+, PUNCT O
+but CCONJ O
+unedited ADJ O
+dsRNA PROPN B-AC
+activates VERB O
+innate ADJ O
+immunity NOUN O
+( PUNCT O
+red ADJ O
+) PUNCT O
+. PUNCT O
+( PUNCT O
+C PROPN O
+) PUNCT O
+Schematic ADJ O
+representation NOUN O
+of ADP O
+the DET O
+generation NOUN O
+of ADP O
+immunogenic ADJ O
+duplex NOUN O
+RNA NOUN O
+( PUNCT O
+panhandle NOUN O
+structures NOUN O
+) PUNCT O
+during ADP O
+viral ADJ O
+infection NOUN O
+and CCONJ O
+the DET O
+impact NOUN O
+of ADP O
+ADAR1 PROPN B-AC
+on ADP O
+PKR- PROPN B-AC
+and CCONJ O
+MDA-5 PROPN B-AC
+- PUNCT O
+mediated VERB O
+innate ADJ O
+immunity NOUN O
+activation NOUN O
+by ADP O
+these DET O
+RNAs NOUN O
+. PUNCT O
+ADAR1 PROPN B-AC
+, PUNCT O
+adenosine NOUN B-LF
+deaminase NOUN I-LF
+acting VERB I-LF
+on ADP I-LF
+RNA NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+DI PROPN B-AC
+, PUNCT O
+defective ADJ B-LF
+interfering VERB I-LF
+; PUNCT O
+dsRNA PROPN B-AC
+, PUNCT O
+double ADJ O
+- PUNCT O
+stranded ADJ O
+RNA NOUN O
+; PUNCT O
+IFN PROPN B-AC
+, PUNCT O
+interferon NOUN B-LF
+; PUNCT O
+MDA-5 PROPN B-AC
+, PUNCT O
+melanoma NOUN B-LF
+differentiation NOUN I-LF
+– PUNCT I-LF
+associated VERB I-LF
+gene NOUN I-LF
+5 NUM I-LF
+; PUNCT O
+MeV PROPN B-AC
+- PUNCT B-AC
+CKO PROPN B-AC
+, PUNCT O
+MeV PROPN B-LF
+unable ADJ I-LF
+to PART I-LF
+express VERB I-LF
+C PROPN I-LF
+protein NOUN I-LF
+; PUNCT O
+PKR PROPN B-AC
+, PUNCT O
+protein NOUN B-LF
+kinase NOUN I-LF
+R. NOUN I-LF
+
+Hunter PROPN O
+and CCONJ O
+colleagues NOUN O
+[ X O
+4 X O
+] X O
+reported VERB O
+highly ADV O
+variable ADJ O
+frequencies NOUN O
+of ADP O
+disomes NOUN O
+for ADP O
+different ADJ O
+chromosomes NOUN B-LF
+, PUNCT O
+ranging VERB O
+from ADP O
+0 NUM O
+% PUNCT O
+( PUNCT O
+chromosome NOUN B-LF
+[ X O
+Chr NOUN B-AC
+] X O
+VI NOUN O
+) PUNCT O
+to ADP O
+27.2 NUM O
+% PUNCT O
+( PUNCT O
+Chr NOUN B-AC
+II NUM O
+) PUNCT O
+with ADP O
+a DET O
+mean ADJ O
+of ADP O
+12.2 NUM O
+% PUNCT O
+, PUNCT O
+corresponding VERB O
+to ADP O
+1.95 NUM O
+disomes NOUN O
+per ADP O
+cell NOUN O
+( PUNCT O
+mean ADJ O
+number NOUN O
+of ADP O
+disomes NOUN O
+= PUNCT O
+16 NUM O
+× SYM O
+mean ADJ O
+frequency NOUN O
+of ADP O
+nondisjunction NOUN O
+) PUNCT O
+. PUNCT O
+
+CEDIF PROPN B-AC
+, PUNCT O
+central ADJ B-LF
+dogma NOUN I-LF
+information NOUN I-LF
+flow NOUN I-LF
+; PUNCT O
+CT PROPN B-AC
+, PUNCT O
+constant ADJ B-LF
+time NOUN I-LF
+; PUNCT O
+R.E. PROPN O
+, PUNCT O
+relative ADJ O
+expression NOUN O
+; PUNCT O
+RNA NOUN B-AC
+- PROPN B-AC
+Seq PROPN B-AC
+, PUNCT O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT O
+STRING PROPN B-AC
+, PUNCT O
+Search PROPN B-LF
+Tool PROPN I-LF
+for ADP I-LF
+the DET I-LF
+Retrieval PROPN I-LF
+of ADP I-LF
+Interacting PROPN I-LF
+Genes PROPN I-LF
+/ SYM I-LF
+Proteins NOUN I-LF
+; PUNCT O
+UPR PROPN B-AC
+, PUNCT O
+Unfolded PROPN B-LF
+Protein PROPN I-LF
+Response PROPN I-LF
+; PUNCT O
+XBP1 PROPN O
+, PUNCT O
+X PROPN O
+- PROPN O
+box PROPN O
+Binding PROPN O
+Protein PROPN O
+1 NUM O
+; PUNCT O
+ZT PROPN B-AC
+, PUNCT O
+Zeitgeber PROPN B-LF
+time NOUN I-LF
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+a DET O
+point NOUN O
+mutation NOUN O
+introducing VERB O
+a DET O
+uORF NOUN B-AC
+in ADP O
+the DET O
+5′ NUM O
+UTR NOUN B-AC
+of ADP O
+CDKN2A PROPN B-AC
+decreases VERB O
+cyclin NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+kinase NOUN I-LF
+inhibitor NOUN I-LF
+2A NOUN I-LF
+( PUNCT O
+CDKN2A PROPN B-AC
+) PUNCT O
+protein NOUN O
+level NOUN O
+and CCONJ O
+causes VERB O
+melanoma NOUN O
+[ PUNCT O
+50 NUM O
+, PUNCT O
+51 NUM O
+] PUNCT O
+. PUNCT O
+
+Data NOUN O
+are AUX O
+available ADJ O
+at ADP O
+https://github.com/ZhixuanXu/Nonadaptive-alternative-TSSs X B-AC
+. PUNCT O
+BRE PROPN B-AC
+, PUNCT O
+TFIIB NOUN B-LF
+recognition NOUN I-LF
+element NOUN I-LF
+; PUNCT O
+DPE PROPN B-AC
+, PUNCT O
+downstream ADJ B-LF
+promoter NOUN I-LF
+element NOUN I-LF
+; PUNCT O
+INR PROPN B-AC
+, PUNCT O
+initiator NOUN B-LF
+; PUNCT O
+nt NOUN O
+, PUNCT O
+nucleotide NOUN O
+; PUNCT O
+TATA PROPN O
+, PUNCT O
+TATA PROPN O
+box NOUN O
+; PUNCT O
+TSS PROPN B-AC
+, PUNCT O
+transcription NOUN B-LF
+start NOUN I-LF
+site NOUN I-LF
+. PUNCT O
+
+EF PROPN B-AC
+, PUNCT O
+ejection NOUN B-LF
+fraction NOUN I-LF
+; PUNCT O
+CVA PROPN B-AC
+, PUNCT O
+cerebrovascular ADJ B-LF
+accident NOUN I-LF
+; PUNCT O
+NYHA PROPN B-AC
+, PUNCT O
+New PROPN B-LF
+York PROPN I-LF
+Heart PROPN I-LF
+Association PROPN I-LF
+; PUNCT O
+CRP PROPN B-AC
+, PUNCT O
+C NOUN B-LF
+- ADJ I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+, PUNCT O
+BUN PROPN O
+, PUNCT O
+blood NOUN O
+urea NOUN O
+nitrogen NOUN O
+; PUNCT O
+PVD NOUN B-AC
+, PUNCT O
+peripheral ADJ B-LF
+vascular ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+25(OH)D NOUN B-AC
+, PUNCT O
+25 NUM B-LF
+- ADJ I-LF
+hydroxy NOUN I-LF
+vitamin NOUN I-LF
+D NOUN I-LF
+
+Likelihood NOUN B-LF
+Ratio NOUN I-LF
+( PUNCT O
+LR PROPN B-AC
+) PUNCT O
+test NOUN O
+, PUNCT O
+Intra ADJ O
+- PUNCT O
+class NOUN O
+Correlation PROPN O
+Coefficient PROPN O
+( PUNCT O
+ICC PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+Median ADJ O
+Odds NOUN O
+Ratio NOUN O
+( PUNCT O
+MOR PROPN O
+) PUNCT O
+were AUX O
+computed VERB O
+to PART O
+measure VERB O
+the DET O
+variation NOUN O
+of ADP O
+anemia NOUN O
+across ADP O
+clusters NOUN O
+. PUNCT O
+
+AKD PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+AKI PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+kidney NOUN I-LF
+injury NOUN I-LF
+; PUNCT O
+CKD PROPN B-AC
+, PUNCT O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+NKD PROPN B-AC
+, PUNCT O
+no DET B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+. PUNCT O
+
+Rat ADJ O
+primary ADJ O
+dermal ADJ O
+fibroblasts NOUN O
+were AUX O
+purchased VERB O
+from ADP O
+the DET O
+European PROPN B-LF
+Collection PROPN I-LF
+of ADP I-LF
+Authenticated PROPN I-LF
+Cell PROPN I-LF
+Cultures PROPN I-LF
+( PUNCT O
+ECACC PROPN B-AC
+) PUNCT O
+( PUNCT O
+catalogue NOUN O
+number NOUN O
+06090769 NUM O
+) PUNCT O
+. PUNCT O
+
+Our PRON O
+results NOUN O
+from ADP O
+Nigeria PROPN O
+share VERB O
+similarities NOUN O
+and CCONJ O
+differences NOUN O
+with ADP O
+results NOUN O
+from ADP O
+oxygen NOUN O
+improvement NOUN O
+programs NOUN O
+in ADP O
+other ADJ O
+low- ADJ B-LF
+and CCONJ I-LF
+middle ADJ I-LF
+- PUNCT I-LF
+income NOUN I-LF
+countries NOUN I-LF
+( PUNCT O
+LMICs PROPN B-AC
+) PUNCT O
+[ PUNCT O
+3 NUM O
+, PUNCT O
+6 NUM O
+] PUNCT O
+. PUNCT O
+
+Pairwise ADJ O
+structure NOUN O
+alignment NOUN O
+programs NOUN O
+fall VERB O
+into ADP O
+three NUM O
+broad ADJ O
+classes NOUN O
+: PUNCT O
+the DET O
+first ADJ O
+class NOUN O
+, PUNCT O
+to PART O
+which PRON O
+Matt PROPN O
+belongs VERB O
+, PUNCT O
+are AUX O
+aligned VERB B-LF
+fragment NOUN I-LF
+pair NOUN I-LF
+( PUNCT O
+AFP PROPN B-AC
+) PUNCT O
+chaining NOUN O
+methods NOUN O
+[ X O
+13,14 NUM O
+] X O
+which PRON O
+do VERB O
+an DET O
+all PRON O
+- PUNCT O
+against ADP O
+- PUNCT O
+all PRON O
+best ADJ O
+transformation NOUN O
+of ADP O
+short ADJ O
+protein NOUN O
+fragments NOUN O
+from ADP O
+one NUM O
+protein NOUN O
+structure NOUN O
+onto ADP O
+another PRON O
+, PUNCT O
+and CCONJ O
+assemble VERB O
+these PRON O
+in ADP O
+a DET O
+geometrically ADV O
+consistent ADJ O
+fashion NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+. PUNCT O
+
+Arch PROPN B-AC
+, PUNCT O
+archaerhodopsin-3 NOUN B-LF
+; PUNCT O
+En1 PROPN B-AC
+, PUNCT O
+engrailed-1 NOUN B-LF
+; PUNCT O
+tdT PROPN B-AC
+, PUNCT O
+tdTomato PROPN B-LF
+. PUNCT O
+
+AP PROPN B-AC
+, PUNCT O
+alkaline ADJ B-LF
+phosphatase NOUN I-LF
+; PUNCT O
+ICTP PROPN B-AC
+, PUNCT O
+C NOUN B-LF
+- PUNCT I-LF
+telopeptide NOUN I-LF
+of ADP I-LF
+type-1 NOUN I-LF
+collagen NOUN I-LF
+; PUNCT O
+OPG PROPN B-AC
+, PUNCT O
+osteoprotegerin NOUN B-LF
+; PUNCT O
+PTH PROPN B-AC
+, PUNCT O
+parathyroid NOUN B-LF
+hormone NOUN I-LF
+; PUNCT O
+sRANKL PROPN O
+, PUNCT O
+soluble ADJ O
+receptor NOUN O
+activator NOUN O
+of ADP O
+nuclear ADJ O
+factor NOUN O
+kappa NOUN O
+B PROPN O
+ligand NOUN O
+; PUNCT O
+TP1NP PROPN B-AC
+, PUNCT O
+total ADJ B-LF
+procollagen NOUN I-LF
+type-1 NOUN I-LF
+intact ADJ I-LF
+N NOUN I-LF
+- PUNCT I-LF
+terminal ADJ I-LF
+propeptide NOUN I-LF
+; PUNCT O
+TRAP5b PROPN B-AC
+, PUNCT O
+tartrate NOUN B-LF
+- PUNCT I-LF
+resistant ADJ I-LF
+acid NOUN I-LF
+phosphatase NOUN I-LF
+type NOUN I-LF
+5b NUM I-LF
+. PUNCT O
+
+A. X O
+Correlation NOUN O
+between ADP O
+RDW PROPN B-AC
+and CCONJ O
+TNM PROPN O
+stage NOUN O
+of ADP O
+NSCLC PROPN B-AC
+. PUNCT O
+RDW PROPN B-AC
+red ADJ B-LF
+blood NOUN I-LF
+cell NOUN I-LF
+distribution NOUN I-LF
+width NOUN I-LF
+; PUNCT O
+NSCLC PROPN B-AC
+non ADJ B-LF
+- ADJ I-LF
+small ADJ I-LF
+cell NOUN I-LF
+lung NOUN I-LF
+cancer NOUN I-LF
+. PUNCT O
+
+Nevertheless ADV O
+, PUNCT O
+the DET O
+characteristics NOUN O
+of ADP O
+positively ADV B-LF
+selected VERB I-LF
+genes NOUN I-LF
+( PUNCT O
+PSGs PROPN B-AC
+) PUNCT O
+, PUNCT O
+have AUX O
+not PART O
+been AUX O
+well ADV O
+investigated VERB O
+. PUNCT O
+
+GIG PROPN B-AC
+is AUX O
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+the DET O
+BTB PROPN B-AC
+( PUNCT O
+Bric PROPN B-LF
+- NOUN I-LF
+a NOUN I-LF
+- NOUN I-LF
+brac PROPN I-LF
+, PUNCT I-LF
+Tramtrack PROPN I-LF
+and CCONJ I-LF
+Broad)/Kelch PROPN I-LF
+superfamily NOUN O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+See VERB O
+Text NOUN O
+S3 PROPN O
+for ADP O
+definitions NOUN O
+and CCONJ O
+calculations NOUN O
+of ADP O
+odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+1 NUM O
+, PUNCT O
+OR NOUN B-AC
+2 NUM O
+, PUNCT O
+and CCONJ O
+OR NOUN B-AC
+3 NUM O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+this DET O
+manner NOUN O
+, PUNCT O
+we PRON O
+defined VERB O
+five NUM O
+time NOUN B-LF
+classes NOUN I-LF
+( PUNCT O
+TC NOUN B-AC
+) PUNCT O
+and CCONJ O
+color NOUN O
+- PUNCT O
+coded VERB O
+them PRON O
+as SCONJ O
+follows VERB O
+: PUNCT O
+TC1 NOUN O
+in ADP O
+purple NOUN O
+: PUNCT O
+65–75 NUM O
+h NOUN O
+after ADP B-LF
+egg NOUN I-LF
+laying NOUN I-LF
+( PUNCT O
+AEL NOUN B-AC
+) PUNCT O
+; PUNCT O
+TC2 PROPN O
+in ADP O
+green NOUN O
+: PUNCT O
+75–85 NUM O
+h NOUN O
+AEL NOUN B-AC
+; PUNCT O
+TC3 PROPN O
+in ADP O
+orange NOUN O
+: PUNCT O
+85–95 NUM O
+h NOUN O
+AEL NOUN B-AC
+; PUNCT O
+TC4 PROPN O
+in ADP O
+blue NOUN O
+: PUNCT O
+95–105 NUM O
+h NOUN O
+AEL NOUN B-AC
+; PUNCT O
+TC5 PROPN O
+in ADP O
+red NOUN O
+: PUNCT O
+105–120 NUM O
+h NOUN O
+AEL NOUN B-AC
+( PUNCT O
+Figure NOUN O
+2A NUM O
+) PUNCT O
+. PUNCT O
+Note VERB O
+that SCONJ O
+timing NOUN O
+refers VERB O
+to ADP O
+hours NOUN O
+after ADP B-LF
+egg NOUN I-LF
+laying NOUN I-LF
+and CCONJ O
+not PART O
+to ADP O
+hours NOUN O
+after ADP O
+hatching NOUN O
+; PUNCT O
+a DET O
+larva NOUN O
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+70 NUM O
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+AEL NOUN B-AC
+would AUX O
+be AUX O
+46 NUM O
+- PUNCT O
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+- PUNCT O
+old ADJ O
+after ADP O
+hatching NOUN O
+. PUNCT O
+
+We PRON O
+also ADV O
+compared VERB O
+the DET O
+diagnostic ADJ B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+DOR PROPN B-AC
+) PUNCT O
+, PUNCT O
+heterogeneity NOUN O
+in ADP O
+DOR PROPN B-AC
+, PUNCT O
+and CCONJ O
+false ADJ B-LF
+positive ADJ I-LF
+rate NOUN I-LF
+( PUNCT O
+FPR NOUN B-AC
+) PUNCT O
+for ADP O
+each DET O
+signature NOUN O
+using VERB O
+bivariate ADJ O
+meta NOUN O
+- NOUN O
+analysis NOUN O
+. PUNCT O
+
+While SCONJ O
+inhibitors NOUN O
+of ADP O
+both CCONJ O
+histone NOUN B-LF
+deacetylase NOUN I-LF
+( PUNCT O
+HDAC PROPN B-AC
+) PUNCT O
+and CCONJ O
+lysine NOUN O
+- PUNCT O
+specific ADJ O
+demethylase-1 NOUN O
+( PUNCT O
+LSD1 PROPN B-AC
+) PUNCT O
+subunits NOUN O
+of ADP O
+the DET O
+NuRD PROPN B-AC
+complex NOUN O
+demonstrate VERB O
+single ADJ O
+agent NOUN O
+activity NOUN O
+in ADP O
+preclinical ADJ O
+models NOUN O
+, PUNCT O
+combination NOUN O
+strategies NOUN O
+have AUX O
+not PART O
+been AUX O
+investigated VERB O
+. PUNCT O
+
+Unadjusted ADJ O
+associations NOUN O
+of ADP O
+central ADJ O
+( PUNCT O
+A NOUN O
+- PUNCT O
+C NOUN O
+) PUNCT O
+and CCONJ O
+peripheral ADJ O
+( PUNCT O
+D NOUN O
+) PUNCT O
+pulse NOUN B-LF
+wave NOUN I-LF
+velocity NOUN I-LF
+( PUNCT O
+PWV PROPN B-AC
+) PUNCT O
+measures NOUN O
+with ADP O
+NT PROPN B-AC
+- PUNCT B-AC
+proBNP PROPN B-AC
+. PUNCT O
+
+Pheochromocytomas NOUN O
+can AUX O
+arise VERB O
+as ADP O
+a DET O
+result NOUN O
+of ADP O
+mutations NOUN O
+in ADP O
+the DET O
+following ADJ O
+disease NOUN O
+- PUNCT O
+associated VERB O
+genes NOUN O
+: PUNCT O
+RET PROPN O
+in ADP O
+multiple ADJ B-LF
+endocrine ADJ I-LF
+neoplasia NOUN I-LF
+type NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+MEN2 PROPN B-AC
+) PUNCT O
+; PUNCT O
+VHL PROPN B-AC
+in ADP O
+von PROPN B-LF
+Hippel PROPN I-LF
+- PUNCT I-LF
+Lindau PROPN I-LF
+disease NOUN I-LF
+( PUNCT O
+VHL PROPN B-AC
+) PUNCT O
+; PUNCT O
+NF1 PROPN B-AC
+in ADP O
+neurofibromatosis NOUN B-LF
+type NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+NF1 PROPN B-AC
+) PUNCT O
+; PUNCT O
+and CCONJ O
+succinate NOUN B-LF
+dehydrogenase NOUN I-LF
+( PUNCT O
+SDH PROPN B-AC
+) PUNCT O
+subunits NOUN O
+B NOUN O
+, PUNCT O
+C PROPN O
+, PUNCT O
+or CCONJ O
+D NOUN O
+in ADP O
+familial ADJ O
+paraganglioma NOUN O
+syndromes NOUN O
+type NOUN O
+4 NUM O
+( PUNCT O
+PGL4 PROPN O
+) PUNCT O
+, PUNCT O
+type NOUN O
+3 NUM O
+( PUNCT O
+PGL3 PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+type NOUN O
+1 NUM O
+( PUNCT O
+PGL1 PROPN O
+) PUNCT O
+, PUNCT O
+respectively ADV O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+have AUX O
+carefully ADV O
+analyzed VERB O
+the DET O
+transcription NOUN O
+profiles NOUN O
+of ADP O
+three NUM O
+highly ADV O
+purified ADJ O
+subpopulations NOUN O
+within ADP O
+the DET O
+mouse NOUN O
+adult NOUN O
+bone NOUN O
+marrow NOUN O
+lineage−/c NOUN O
+- PUNCT O
+kit+/Sca1 NOUN O
++ NOUN O
+( PUNCT O
+KLS PROPN O
+) PUNCT O
+fraction NOUN O
+: PUNCT O
+LT PROPN B-AC
+- PUNCT O
+HSC PROPN B-AC
+( PUNCT O
+defined VERB O
+as ADP O
+Thy1.1lo NOUN O
+/ SYM O
+Flk2− NOUN O
+KLS PROPN O
+) PUNCT O
+, PUNCT O
+short ADJ B-LF
+- PUNCT I-LF
+term NOUN I-LF
+( PUNCT O
+ST)-HSC PROPN B-AC
+( PUNCT O
+Thy1.1lo NOUN O
+/ SYM O
+Flk2 PROPN O
++ NOUN O
+KLS PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+multipotent ADJ O
+progenitors NOUN O
+( PUNCT O
+MPP PROPN B-AC
+) PUNCT O
+( PUNCT O
+Thy1.1−/Flk2 NOUN O
++ NOUN O
+KLS PROPN O
+) PUNCT O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+Normal ADJ O
+( PUNCT O
+NF PROPN B-AC
+) PUNCT O
+and CCONJ O
+cancer NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+fibroblasts NOUN I-LF
+( PUNCT O
+CAFs PROPN B-AC
+) PUNCT O
+were AUX O
+isolated VERB O
+previously ADV O
+[ X O
+1 X O
+] X O
+from ADP O
+female ADJ O
+patients NOUN O
+with ADP O
+ER NOUN B-AC
+positive ADJ O
+, PUNCT O
+HER–2 PROPN B-AC
+negative ADJ O
+, PUNCT O
+grade NOUN O
+2 NUM O
+ductal ADJ O
+NST PROPN O
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+with ADP O
+no DET O
+lymph NOUN O
+node NOUN O
+involvement NOUN O
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+
+Therefore ADV O
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+objective NOUN O
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+study NOUN O
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+to PART O
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+LCB PROPN B-AC
+containing VERB O
+a DET O
+mix NOUN O
+of ADP O
+pine NOUN B-LF
+bark NOUN I-LF
+( PUNCT O
+PB PROPN B-AC
+) PUNCT O
+, PUNCT O
+chopped VERB B-LF
+paper NOUN I-LF
+napkins NOUN I-LF
+( PUNCT O
+CPN PROPN B-AC
+) PUNCT O
+and CCONJ O
+brewing NOUN B-LF
+yeast NOUN I-LF
+hydrolysate NOUN I-LF
+( PUNCT O
+BYH PROPN B-AC
+) PUNCT O
+and CCONJ O
+LDPEoxo PROPN B-AC
+employing VERB O
+P. PROPN O
+ostreatus NOUN O
+at ADP O
+microcosm NOUN O
+scale NOUN O
+to PART O
+obtain VERB O
+oxidized VERB O
+LCB PROPN B-AC
+and CCONJ O
+biotransformed VERB O
+plastic NOUN O
+as ADP O
+RM PROPN B-AC
+to PART O
+produce VERB O
+biochar NOUN O
+enriched VERB O
+with ADP O
+PSB PROPN B-AC
+. PUNCT O
+Its PRON O
+potential ADJ O
+use NOUN O
+was AUX O
+evaluated VERB O
+as ADP O
+a DET O
+biofertilizer NOUN O
+in ADP O
+Allium PROPN O
+cepa PROPN O
+at ADP O
+seedbed NOUN O
+scale NOUN O
+. PUNCT O
+
+To PART O
+quantify VERB O
+how SCONJ O
+predictive ADJ O
+variations NOUN O
+in ADP O
+the DET O
+genomic ADJ O
+states NOUN O
+are AUX O
+of ADP O
+differential ADJ O
+gene NOUN O
+expression NOUN O
+at ADP O
+the DET O
+transcriptomic ADJ O
+level NOUN O
+, PUNCT O
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+compare VERB O
+Gene PROPN B-LF
+Ontology PROPN I-LF
+( PUNCT O
+GO PROPN B-AC
+) PUNCT O
+[ X O
+62,63 NUM O
+] X O
+terms NOUN O
+associated VERB O
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+consequence NOUN O
+genetic ADJ O
+sequence NOUN O
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+( PUNCT O
+“ PUNCT O
+low ADJ O
+, PUNCT O
+” PUNCT O
+“ PUNCT O
+moderate ADJ O
+, PUNCT O
+” PUNCT O
+and CCONJ O
+“ PUNCT O
+high ADJ O
+” PUNCT O
+IMPACT NOUN O
+scores NOUN O
+) PUNCT O
+and CCONJ O
+GO PROPN B-AC
+terms NOUN O
+associated VERB O
+with ADP O
+significantly ADV O
+differentially ADV B-LF
+expressed VERB I-LF
+genes NOUN I-LF
+( PUNCT O
+DEGs PROPN B-AC
+; PUNCT O
+adjusted VERB O
+p NOUN O
+< ADP O
+0.05 NUM O
+) PUNCT O
+. PUNCT O
+
+According VERB O
+to PART O
+the DET O
+diagnosis NOUN B-LF
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+characteristics NOUN I-LF
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+sclerosis NOUN I-LF
+common ADJ I-LF
+data NOUN I-LF
+elements NOUN I-LF
+from ADP I-LF
+the DET I-LF
+National PROPN I-LF
+Institute PROPN I-LF
+of ADP I-LF
+Neurological PROPN I-LF
+Disorders PROPN I-LF
+and CCONJ I-LF
+Stroke PROPN I-LF
+( PUNCT O
+MS PROPN B-AC
+CDEs NOUN B-AC
+) PUNCT O
+catalog NOUN O
+, PUNCT O
+more ADJ O
+than ADP O
+1600 NUM O
+distinct ADJ O
+CDEs NOUN B-AC
+have AUX O
+been AUX O
+developed VERB O
+to PART O
+document VERB O
+MS PROPN B-AC
+in ADP O
+clinical ADJ O
+trials NOUN O
+funded VERB O
+by ADP O
+NINDS PROPN B-AC
+, PUNCT O
+of ADP O
+which PRON O
+about ADV O
+20 NUM O
+items NOUN O
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+declared VERB O
+as ADP O
+core NOUN O
+or CCONJ O
+highly ADV O
+recommended VERB O
+, PUNCT O
+depending VERB O
+on ADP O
+the DET O
+study NOUN O
+type NOUN O
+[ PUNCT O
+55 NUM O
+] PUNCT O
+. PUNCT O
+
+Given VERB O
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+- PUNCT I-LF
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+( PUNCT O
+DR PROPN B-AC
+- PUNCT B-AC
+TB PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+key ADJ O
+driving VERB O
+factor NOUN O
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+TB PROPN B-AC
+mortality NOUN O
+globally ADV O
+, PUNCT O
+implementation NOUN O
+of ADP O
+comprehensive ADJ O
+, PUNCT O
+rapid ADJ O
+drug NOUN B-LF
+susceptibility NOUN I-LF
+testing NOUN I-LF
+( PUNCT O
+DST NOUN B-AC
+) PUNCT O
+is AUX O
+critical ADJ O
+in ADP O
+all DET O
+settings NOUN O
+. PUNCT O
+
+As ADV O
+many ADJ O
+as ADP O
+half NOUN O
+of ADP O
+cirrhotic ADJ O
+patients NOUN O
+showed VERB O
+signs NOUN O
+of ADP O
+diastolic ADJ O
+dysfunction NOUN O
+within ADP O
+the DET O
+first ADJ O
+week NOUN O
+after ADP O
+liver NOUN B-LF
+transplantation NOUN I-LF
+( PUNCT O
+LT NOUN B-AC
+) PUNCT O
+[ X O
+6,7 NUM O
+] PUNCT O
+. PUNCT O
+
+Basic ADJ B-LF
+Local PROPN I-LF
+Alignment PROPN I-LF
+Search PROPN I-LF
+Tool PROPN I-LF
+( PUNCT O
+Blast PROPN B-AC
+, PUNCT O
+Blastp PROPN O
+[ PUNCT O
+41 NUM O
+] PUNCT O
+) PUNCT O
+was AUX O
+employed VERB O
+to PART O
+detect VERB O
+the DET O
+sequences NOUN O
+that PRON O
+were AUX O
+mapped VERB O
+against ADP O
+the DET O
+non ADJ O
+- ADJ O
+redundant ADJ O
+NCBI PROPN B-AC
+protein NOUN O
+database NOUN O
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+the DET O
+best ADJ O
+Blast PROPN B-AC
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+. PUNCT O
+
+These DET O
+events NOUN O
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+reminiscent ADJ O
+of ADP O
+the DET O
+Salmonella PROPN O
+system NOUN O
+in ADP O
+which PRON O
+at ADP O
+high ADJ O
+multiplicity NOUN B-LF
+of ADP I-LF
+infection NOUN I-LF
+( PUNCT O
+MOI PROPN B-AC
+) PUNCT O
+, PUNCT O
+there PRON O
+is AUX O
+residual ADJ O
+IL-1β NOUN B-AC
+secretion NOUN O
+that PRON O
+is AUX O
+induced VERB O
+independently ADV O
+of ADP O
+cytosolic ADJ O
+flagellin NOUN O
+and CCONJ O
+, PUNCT O
+presumably ADV O
+, PUNCT O
+of ADP O
+Ipaf PROPN O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+contrast NOUN O
+to ADP O
+colon NOUN O
+cancer NOUN O
+, PUNCT O
+current ADJ O
+guidelines NOUN O
+recommend VERB O
+preoperative ADJ B-LF
+chemo NOUN I-LF
+- PUNCT I-LF
+radiotherapy NOUN I-LF
+( PUNCT O
+preCRT PROPN B-AC
+) PUNCT O
+for ADP O
+patients NOUN O
+with ADP O
+advanced ADJ O
+rectal ADJ O
+cancer.[3 NOUN O
+, PUNCT O
+5 NUM O
+] PUNCT O
+Previous ADJ O
+studies NOUN O
+evaluating VERB O
+the DET O
+optimal ADJ O
+timing NOUN O
+of ADP O
+AC PROPN B-AC
+specifically ADV O
+in ADP O
+rectal ADJ O
+cancer NOUN O
+suggested VERB O
+a DET O
+period NOUN O
+of ADP O
+8 NUM O
+weeks NOUN O
+after ADP O
+surgery NOUN O
+, PUNCT O
+similar ADJ O
+to ADP O
+colon NOUN O
+cancer NOUN O
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+however ADV O
+, PUNCT O
+preCRT PROPN B-AC
+was AUX O
+not PART O
+considered.[28 NUM O
+, PUNCT O
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+] PUNCT O
+Currently ADV O
+, PUNCT O
+there PRON O
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+evidence NOUN O
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+support VERB O
+to ADP O
+AC PROPN B-AC
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+patients NOUN O
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+received VERB O
+preCRT PROPN B-AC
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+MR PROPN B-AC
+, PUNCT O
+mendelian ADJ B-LF
+randomisation NOUN I-LF
+. PUNCT O
+
+In ADP O
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+, PUNCT O
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+PCP PROPN B-AC
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+virus NOUN I-LF
+( PUNCT O
+HIV PROPN B-AC
+) PUNCT O
+infection NOUN O
+and CCONJ O
+renal ADJ B-LF
+transplant NOUN I-LF
+recipients NOUN I-LF
+( PUNCT O
+RTRs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Lovastatin NOUN O
+, PUNCT O
+fluvastatin NOUN O
+sodium NOUN O
+, PUNCT O
+simvastatin NOUN O
+, PUNCT O
+atorvastatin NOUN O
+, PUNCT O
+CoQ10 PROPN B-AC
+, PUNCT O
+and CCONJ O
+mevalonic ADJ O
+acid NOUN O
+( PUNCT O
+MVA PROPN B-AC
+) PUNCT O
+were AUX O
+purchased VERB O
+from ADP O
+Cayman PROPN O
+Chemical PROPN O
+( PUNCT O
+Ann PROPN O
+Arbor PROPN O
+, PUNCT O
+MI PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+. PUNCT O
+2 NUM O
+- PUNCT O
+Deoxy NOUN O
+- PUNCT O
+D NOUN O
+- PUNCT O
+glucose NOUN O
+( PUNCT O
+2 NUM O
+- PUNCT O
+DG PROPN O
+) PUNCT O
+, PUNCT O
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+cyanide NOUN I-LF
+4-(trifluoromethoxy NOUN I-LF
+) PUNCT I-LF
+phenylhydrazone NOUN I-LF
+( PUNCT O
+FCCP PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+oligomycin NOUN O
+A PROPN O
+were AUX O
+purchased VERB O
+from ADP O
+MedChem PROPN O
+Express PROPN O
+( PUNCT O
+Monmouth PROPN O
+Junction PROPN O
+, PUNCT O
+NJ PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+. PUNCT O
+Cholesterol NOUN O
+- PUNCT O
+Water PROPN O
+Soluble PROPN O
+, PUNCT O
+FPP PROPN B-AC
+, PUNCT O
+geranylgeranyl NOUN B-LF
+pyrophosphate NOUN I-LF
+( PUNCT O
+GGPP PROPN B-AC
+) PUNCT O
+, PUNCT O
+trichloroacetic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+TCA PROPN B-AC
+) PUNCT O
+, PUNCT O
+CHX PROPN B-AC
+, PUNCT O
+MG132 PROPN O
+, PUNCT O
+DNase NOUN O
+- PUNCT O
+free ADJ O
+RNase PROPN O
+A PROPN O
+, PUNCT O
+triton NOUN O
+X-100 PROPN O
+, PUNCT O
+crystal NOUN O
+violet NOUN O
+, PUNCT O
+and CCONJ O
+sulforhodamine NOUN B-LF
+B PROPN I-LF
+( PUNCT O
+SRB PROPN B-AC
+) PUNCT O
+were AUX O
+obtained VERB O
+from ADP O
+Sigma PROPN O
+Aldrich PROPN O
+( PUNCT O
+St. PROPN O
+Louis PROPN O
+, PUNCT O
+MO PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+. PUNCT O
+Antibody NOUN O
+sources NOUN O
+were AUX O
+as SCONJ O
+follows VERB O
+: PUNCT O
+HMGCR PROPN B-AC
+( PUNCT O
+BD PROPN O
+Biosciences PROPN O
+, PUNCT O
+San PROPN O
+Jose PROPN O
+, PUNCT O
+CA PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+; PUNCT O
+PKM2 PROPN B-AC
+( PUNCT O
+Cell PROPN O
+Signaling PROPN O
+, PUNCT O
+Danvers PROPN O
+, PUNCT O
+MA PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+; PUNCT O
+Hsp90 PROPN O
+( PUNCT O
+Abcam PROPN O
+, PUNCT O
+Cambridge PROPN O
+, PUNCT O
+Cambridgeshire PROPN O
+, PUNCT O
+UK PROPN O
+) PUNCT O
+, PUNCT O
+β NOUN O
+- PUNCT O
+actin NOUN O
+( PUNCT O
+Sigma PROPN O
+- PUNCT O
+Aldrich PROPN O
+, PUNCT O
+St. PROPN O
+Louis PROPN O
+, PUNCT O
+MO PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+; PUNCT O
+horseradish NOUN O
+peroxidase NOUN O
+- PUNCT O
+conjugated VERB O
+secondary ADJ O
+antibodies NOUN O
+( PUNCT O
+Jackson PROPN O
+Laboratory PROPN O
+, PUNCT O
+Bar PROPN O
+Harbor PROPN O
+, PUNCT O
+ME PROPN O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+. PUNCT O
+
+ACE PROPN B-AC
+, PUNCT O
+adverse ADJ B-LF
+childhood NOUN I-LF
+experience NOUN I-LF
+; PUNCT O
+GCSE PROPN B-AC
+, PUNCT O
+General PROPN B-LF
+Certificate PROPN I-LF
+of ADP I-LF
+Secondary PROPN I-LF
+Education PROPN I-LF
+. PUNCT O
+
+The DET O
+Joint PROPN B-LF
+United PROPN I-LF
+Nations PROPN I-LF
+Programme PROPN I-LF
+on ADP I-LF
+HIV PROPN I-LF
+and CCONJ I-LF
+AIDS PROPN I-LF
+( PUNCT O
+UNAIDS PROPN B-AC
+) PUNCT O
+90 NUM O
+- SYM O
+90 NUM O
+- SYM O
+90 NUM O
+targets NOUN O
+have AUX O
+reinforced VERB O
+the DET O
+importance NOUN O
+of ADP O
+functioning VERB O
+laboratory NOUN O
+services NOUN O
+to PART O
+ensure VERB O
+prompt ADJ O
+diagnosis NOUN O
+and CCONJ O
+to PART O
+assess VERB O
+treatment NOUN O
+efficacy NOUN O
+. PUNCT O
+
+MS PROPN B-AC
+, PUNCT O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+; PUNCT O
+M1 PROPN B-AC
+, PUNCT O
+matrix NOUN B-LF
+protein NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+Udorn PROPN B-AC
+, PUNCT O
+A PROPN B-LF
+/ SYM I-LF
+Udorn/1972(H3N2 NOUN I-LF
+) PUNCT I-LF
+filamentous ADJ I-LF
+virus NOUN I-LF
+
+Interrupted ADJ O
+time NOUN O
+series NOUN O
+analysis NOUN O
+showed VERB O
+that SCONJ O
+increases NOUN O
+in ADP O
+store NOUN O
+- PUNCT O
+level NOUN O
+sales NOUN O
+of ADP O
+fruits NOUN O
+and CCONJ O
+vegetables NOUN O
+were AUX O
+greater ADJ O
+in ADP O
+intervention NOUN O
+stores NOUN O
+than SCONJ O
+predicted VERB O
+at ADP O
+3 NUM O
+( PUNCT O
+1.71 NUM O
+standard ADJ B-LF
+deviations NOUN I-LF
+( PUNCT O
+SDs NOUN B-AC
+) PUNCT O
+( PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+0.45 NUM O
+, PUNCT O
+2.96 NUM O
+) PUNCT O
+, PUNCT O
+P NOUN O
+= SYM O
+0.01 NUM O
+) PUNCT O
+and CCONJ O
+6 NUM O
+months NOUN O
+follow NOUN O
+- PUNCT O
+up NOUN O
+( PUNCT O
+2.42 NUM O
+SDs NOUN B-AC
+( PUNCT O
+0.22 NUM O
+, PUNCT O
+4.62 NUM O
+) PUNCT O
+, PUNCT O
+P NOUN O
+= SYM O
+0.03 NUM O
+) PUNCT O
+, PUNCT O
+equivalent ADJ O
+to ADP O
+approximately ADV O
+6,170 NUM O
+and CCONJ O
+approximately ADV O
+9,820 NUM O
+extra ADJ O
+portions NOUN O
+per ADP O
+store NOUN O
+, PUNCT O
+per ADP O
+week NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+Urine ADJ O
+samples NOUN O
+were AUX O
+centrifuged VERB O
+at ADP O
+3000x NUM O
+g NOUN O
+for ADP O
+10 NUM O
+min NOUN O
+and CCONJ O
+kept VERB O
+at ADP O
+-70 NUM O
+° NOUN O
+C NOUN O
+until SCONJ O
+used VERB O
+. PUNCT O
+uNGAL NOUN B-AC
+and CCONJ O
+urinary ADJ O
+IL-18 NOUN B-AC
+, PUNCT O
+IL-6 NOUN B-AC
+and CCONJ O
+tumour NOUN B-LF
+necrosis NOUN I-LF
+factor NOUN I-LF
+α NOUN I-LF
+( PUNCT O
+TNF NOUN B-AC
+- PUNCT B-AC
+α NOUN B-AC
+) PUNCT O
+were AUX O
+measured VERB O
+by ADP O
+enzyme NOUN O
+- PUNCT O
+linked VERB O
+immunosorbent ADJ O
+assay NOUN O
+kits NOUN O
+( PUNCT O
+Raybiotech PROPN O
+, PUNCT O
+Norcross PROPN O
+, PUNCT O
+GA PROPN O
+, PUNCT O
+USA PROPN O
+for ADP O
+urinary ADJ O
+IL-18 NOUN B-AC
+and CCONJ O
+R&D PROPN O
+Systems PROPN O
+, PUNCT O
+Minneapolis PROPN O
+, PUNCT O
+MN PROPN O
+, PUNCT O
+USA PROPN O
+for ADP O
+the DET O
+others NOUN O
+) PUNCT O
+. PUNCT O
+
+CS NOUN B-AC
+, PUNCT O
+complex ADJ B-LF
+spike NOUN I-LF
+. PUNCT O
+
+p.4 X O
+- X O
+5 X O
+: PUNCT O
+In ADP O
+terms NOUN O
+of ADP O
+a DET O
+lack NOUN O
+of ADP O
+evidence NOUN O
+about ADP O
+integrated VERB O
+representations NOUN O
+for ADP O
+verbal ADJ O
+and CCONJ O
+visual ADJ O
+forms NOUN O
+of ADP O
+people NOUN O
+: PUNCT O
+( PUNCT O
+a DET O
+) PUNCT O
+if SCONJ O
+we PRON O
+assume VERB O
+that PRON O
+this DET O
+is AUX O
+part NOUN O
+of ADP O
+general ADJ O
+semantics NOUN O
+then ADV O
+there PRON O
+is AUX O
+converging VERB O
+evidence NOUN O
+for ADP O
+multimodal ADJ O
+semantic ADJ O
+representations NOUN O
+in ADP O
+semantic ADJ B-LF
+dementia NOUN I-LF
+, PUNCT O
+fMRI NOUN B-AC
+, PUNCT O
+TMS PROPN B-AC
+, PUNCT O
+computational ADJ O
+models NOUN O
+, PUNCT O
+etc X O
+. PUNCT O
+( PUNCT O
+for ADP O
+an DET O
+overview NOUN O
+, PUNCT O
+see VERB O
+Lambon PROPN O
+Ralph PROPN O
+et X O
+al NOUN O
+NRN PROPN O
+2017 NUM O
+) PUNCT O
+– PUNCT O
+with ADP O
+, PUNCT O
+for ADP O
+example NOUN O
+, PUNCT O
+Visser PROPN O
+et X O
+al NOUN O
+( PUNCT O
+2011 NUM O
+) PUNCT O
+showing VERB O
+that PRON O
+the DET O
+same ADJ O
+vATL NOUN O
+region NOUN O
+as SCONJ O
+observed VERB O
+in ADP O
+the DET O
+SEEG PROPN B-AC
+in ADP O
+this DET O
+study NOUN O
+is AUX O
+activated VERB O
+by ADP O
+pictures NOUN O
+, PUNCT O
+sounds NOUN O
+and CCONJ O
+spokjen NOUN O
+names NOUN O
+; PUNCT O
+( PUNCT O
+b X O
+) PUNCT O
+SD PROPN B-AC
+patients NOUN O
+show VERB O
+especially ADV O
+poor ADJ O
+performance NOUN O
+for ADP O
+semantic ADJ O
+knowledge NOUN O
+probed VERB O
+at ADV O
+the DET O
+specific ADJ O
+level NOUN O
+including VERB O
+people NOUN O
+and CCONJ O
+show VERB O
+strong ADJ O
+item NOUN O
+associations NOUN O
+when SCONJ O
+knowledge NOUN O
+for ADP O
+a DET O
+concept NOUN O
+is AUX O
+probed VERB O
+using VERB O
+words NOUN O
+or CCONJ O
+pictures NOUN O
+( PUNCT O
+indicating VERB O
+degradation NOUN O
+of ADP O
+a DET O
+shared VERB O
+representation NOUN O
+) PUNCT O
+; PUNCT O
+( PUNCT O
+c X O
+) PUNCT O
+at ADV O
+least ADV O
+one NUM O
+fMRI NOUN B-AC
+study NOUN O
+has AUX O
+probed VERB O
+people NOUN O
+knowledge NOUN O
+with ADP O
+pictures NOUN O
+and CCONJ O
+words NOUN O
+( PUNCT O
+Rice PROPN O
+et X O
+al NOUN O
+2017 NUM O
+Proc PROPN O
+Roy PROPN O
+Soc PROPN O
+) PUNCT O
+which PRON O
+found VERB O
+bilateral ADJ O
+vATL NOUN O
+regions NOUN O
+that PRON O
+responded VERB O
+to ADP O
+both CCONJ O
+the DET O
+spoken VERB O
+names NOUN O
+and CCONJ O
+pictures NOUN O
+of ADP O
+familiar ADJ O
+people NOUN O
+, PUNCT O
+landmarks NOUN O
+and CCONJ O
+animals NOUN O
+. PUNCT O
+
+The DET O
+split ADJ B-LF
+luciferase NOUN I-LF
+complementation NOUN I-LF
+( PUNCT O
+SLC PROPN B-AC
+) PUNCT O
+data NOUN O
+analysis NOUN O
+is AUX O
+described VERB O
+in ADP O
+the DET O
+Supporting VERB O
+information NOUN O
+( PUNCT O
+S1 PROPN O
+Materials NOUN O
+and CCONJ O
+Methods NOUN O
+) PUNCT O
+. PUNCT O
+
+DENV PROPN B-AC
+, PUNCT O
+dengue PROPN B-LF
+virus NOUN I-LF
+; PUNCT O
+GAPDH PROPN B-AC
+, PUNCT O
+glyceraldehyde NOUN B-LF
+3 NUM I-LF
+- PUNCT I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+; PUNCT O
+HeLa PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+epithelial NOUN I-LF
+- PUNCT I-LF
+derived VERB I-LF
+cell NOUN I-LF
+line NOUN I-LF
+; PUNCT O
+hpi PROPN B-AC
+, PUNCT O
+hours NOUN B-LF
+post NOUN I-LF
+infection NOUN I-LF
+; PUNCT O
+MOI PROPN B-AC
+, PUNCT O
+multiplicity NOUN B-LF
+of ADP I-LF
+infection NOUN I-LF
+; PUNCT O
+PFU PROPN B-AC
+, PUNCT O
+plaque NOUN B-LF
+- PUNCT I-LF
+forming VERB I-LF
+units NOUN I-LF
+; PUNCT O
+PV PROPN B-AC
+, PUNCT O
+poliovirus NOUN B-LF
+; PUNCT O
+RT NOUN B-AC
+- PUNCT B-AC
+qPCR PROPN B-AC
+, PUNCT O
+reverse ADJ B-LF
+transcription NOUN I-LF
+quantitative ADJ I-LF
+PCR NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+; PUNCT O
+ZIKV PROPN B-AC
+, PUNCT O
+Zika PROPN B-LF
+virus NOUN I-LF
+. PUNCT O
+
+Intervention NOUN O
+abbreviations NOUN O
+: PUNCT O
+LKM PROPN O
+, PUNCT O
+Loving PROPN O
+– PUNCT O
+Kindness PROPN O
+Meditation PROPN O
+; PUNCT O
+MAPs PROPN O
+; PUNCT O
+Mindful PROPN O
+Awareness PROPN O
+Practices PROPN O
+; PUNCT O
+MBAP PROPN O
+, PUNCT O
+Mindfulness PROPN O
+– PUNCT O
+Based PROPN O
+Art PROPN O
+Processing PROPN O
+; PUNCT O
+MBCT PROPN O
+, PUNCT O
+Mindfulness PROPN O
+– PUNCT O
+Based PROPN O
+Cognitive PROPN O
+Therapy PROPN O
+; PUNCT O
+MBSR PROPN B-AC
+, PUNCT O
+Mindfulness PROPN B-LF
+– PUNCT I-LF
+Based PROPN I-LF
+Stress PROPN I-LF
+Reduction PROPN I-LF
+; PUNCT O
+MiCBT PROPN O
+, PUNCT O
+Mindfulness PROPN O
+– PUNCT O
+Integrated PROPN O
+Cognitive PROPN O
+Behaviour PROPN O
+Therapy PROPN O
+. PUNCT O
+
+Based VERB O
+on ADP O
+criteria NOUN O
+established VERB O
+by ADP O
+Oken PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+, PUNCT O
+we PRON O
+defined VERB O
+SGA PROPN B-AC
+, PUNCT O
+LGA PROPN B-AC
+, PUNCT O
+and CCONJ O
+appropriate ADJ B-LF
+for ADP I-LF
+gestational ADJ I-LF
+age NOUN I-LF
+( PUNCT O
+AGA NOUN B-AC
+) PUNCT O
+by ADP O
+birth NOUN O
+weight NOUN O
+percentiles NOUN O
+for ADP O
+gestational ADJ O
+age NOUN O
+of ADP O
+≤10th ADJ O
+, PUNCT O
+≥90th ADJ O
+, PUNCT O
+and CCONJ O
+> NUM O
+10th ADJ O
+to PART O
+< ADJ O
+90th ADJ O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+We PRON O
+identify VERB O
+approximately ADV O
+230 NUM O
+chromosomal ADJ O
+clusters NOUN O
+of ADP O
+candidate NOUN O
+antagonistic ADJ O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT O
+SNPs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+KEAP1 PROPN B-AC
+is AUX O
+located VERB O
+at ADP O
+19p13.2 NUM O
+and CCONJ O
+has VERB O
+three NUM O
+major ADJ O
+domains NOUN O
+: PUNCT O
+an DET O
+N NOUN O
+- ADJ O
+terminal ADJ O
+broad ADJ B-LF
+complex NOUN I-LF
+, PUNCT I-LF
+tramtrack NOUN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+bric NOUN I-LF
+- ADJ I-LF
+a DET I-LF
+- ADJ I-LF
+brac NOUN I-LF
+( PUNCT O
+BTB PROPN B-AC
+) PUNCT O
+domain NOUN O
+; PUNCT O
+a DET O
+central ADJ O
+intervening VERB B-LF
+region NOUN I-LF
+( PUNCT O
+IVR PROPN B-AC
+) PUNCT O
+; PUNCT O
+and CCONJ O
+a DET O
+series NOUN O
+of ADP O
+six NUM O
+C NOUN O
+- ADJ O
+terminal ADJ O
+Kelch PROPN O
+repeats NOUN O
+[ X O
+21 NUM O
+] X O
+( PUNCT O
+Figure PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+therefore ADV O
+undertook VERB O
+a DET O
+second ADJ O
+cycle NOUN O
+of ADP O
+SAXS PROPN B-AC
+modeling NOUN O
+by ADP O
+incorporating VERB O
+the DET O
+structural ADJ O
+data NOUN O
+deduced VERB O
+from ADP O
+HDX NOUN B-AC
+- PUNCT B-AC
+MS NOUN B-AC
+and CCONJ O
+far ADJ B-LF
+- PUNCT I-LF
+ultraviolet ADJ I-LF
+( PUNCT O
+far ADJ B-AC
+- PUNCT B-AC
+UV NOUN B-AC
+) PUNCT O
+SR NOUN B-AC
+- PUNCT B-AC
+CD NOUN B-AC
+data NOUN O
+. PUNCT O
+
+AMsh PROPN B-AC
+, PUNCT O
+amphid NOUN B-LF
+sheath NOUN I-LF
+; PUNCT O
+D1 NOUN B-AC
+, PUNCT O
+day NOUN B-LF
+1 NUM I-LF
+; PUNCT O
+D2 NOUN B-AC
+, PUNCT O
+day NOUN B-LF
+2 NUM I-LF
+; PUNCT O
+LRO NOUN B-AC
+, PUNCT O
+lysosome NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+organelle NOUN I-LF
+; PUNCT O
+RNAi NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+; PUNCT O
+TEM PROPN B-AC
+, PUNCT O
+transmission NOUN B-LF
+electron NOUN I-LF
+microscopy NOUN I-LF
+; PUNCT O
+WT PROPN O
+, PUNCT O
+wild ADJ O
+- PUNCT O
+type NOUN O
+. PUNCT O
+
+A. X O
+Selected VERB O
+fatty ADJ O
+acid NOUN O
+composition NOUN O
+of ADP O
+epididymal ADJ B-LF
+white ADJ I-LF
+adipose ADJ I-LF
+tissue NOUN I-LF
+( PUNCT O
+EWAT PROPN B-AC
+, PUNCT O
+left ADV O
+) PUNCT O
+or CCONJ O
+inguinal ADJ B-LF
+white ADJ I-LF
+adipose ADJ I-LF
+tissue NOUN I-LF
+( PUNCT O
+IWAT PROPN B-AC
+, PUNCT O
+right ADV O
+) PUNCT O
+from ADP O
+mice NOUN O
+fed VERB O
+the DET O
+indicated VERB O
+diets NOUN O
+. PUNCT O
+
+SD PROPN O
+: PUNCT O
+standard ADJ O
+deviation NOUN O
+, PUNCT O
+OHGA PROPN B-AC
+: PUNCT O
+oral ADJ B-LF
+hypoglycemic ADJ I-LF
+agents NOUN I-LF
+, PUNCT O
+ARBs PROPN O
+: PUNCT O
+Angiotension NOUN O
+II NUM O
+receptor NOUN O
+blockers NOUN O
+
+sway NOUN B-LF
+path NOUN I-LF
+length NOUN I-LF
+of ADP I-LF
+COP PROPN I-LF
+( PUNCT O
+SP PROPN B-AC
+) PUNCT O
+[ X O
+mm]–defines VERB O
+the DET O
+total ADJ O
+length NOUN O
+of ADP O
+path NOUN O
+marked VERB O
+by ADP O
+the DET O
+COP PROPN B-AC
+; PUNCT O
+the DET O
+sum NOUN O
+of ADP O
+distances NOUN O
+between ADP O
+the DET O
+locations NOUN O
+of ADP O
+the DET O
+COP PROPN B-AC
+constitutes VERB O
+the DET O
+path NOUN O
+length NOUN O
+; PUNCT O
+
+Consistent ADJ O
+with ADP O
+Dunn PROPN O
+and CCONJ O
+colleagues NOUN O
+[ PUNCT O
+64 NUM O
+] PUNCT O
+, PUNCT O
+the DET O
+phase NOUN O
+of ADP O
+mapped VERB O
+RPF NOUN B-AC
+reads NOUN O
+along ADP O
+CDS PROPN B-AC
+was AUX O
+compromised VERB O
+, PUNCT O
+owing VERB O
+to ADP O
+the DET O
+cutting VERB O
+bias NOUN O
+of ADP O
+micrococcal NOUN B-LF
+nuclease NOUN I-LF
+( PUNCT O
+MNase NOUN B-AC
+) PUNCT O
+( PUNCT O
+S4 PROPN O
+Fig PROPN O
+and CCONJ O
+S5 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+MC PROPN B-AC
+, PUNCT O
+matching VERB B-LF
+competition NOUN I-LF
+. PUNCT O
+
+The DET O
+average NOUN O
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+three NUM O
+experiments NOUN O
+is AUX O
+shown VERB O
+( PUNCT O
+± PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+[ X O
+SEM X B-AC
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+These DET O
+participants NOUN O
+provided VERB O
+additional ADJ O
+informed ADJ O
+consent NOUN O
+during ADP O
+screening NOUN O
+and CCONJ O
+received VERB O
+HD NOUN B-AC
+- PUNCT B-AC
+MAPs NOUN B-AC
+delivering VERB O
+15 NUM O
+μg NOUN O
+( PUNCT O
+MAP NOUN B-AC
+- PUNCT O
+FA-15 NOUN B-AC
+- PUNCT O
+bio NOUN O
+) PUNCT O
+or CCONJ O
+uncoated VERB O
+HD NOUN B-AC
+- PUNCT B-AC
+MAPs NOUN B-AC
+( PUNCT O
+MAP NOUN B-AC
+- PUNCT O
+FA-0 NOUN B-AC
+- PUNCT O
+bio NOUN O
+) PUNCT O
+applied VERB O
+to ADP O
+the DET O
+forearm NOUN B-LF
+. PUNCT O
+
+Such DET O
+an DET O
+effect NOUN O
+diverges VERB O
+from ADP O
+the DET O
+empirical ADJ O
+fMRI NOUN B-AC
+variability NOUN O
+time NOUN O
+series NOUN O
+, PUNCT O
+which PRON O
+is AUX O
+not PART O
+flat ADJ O
+but CCONJ O
+rather ADV O
+follows VERB O
+a DET O
+trajectory NOUN O
+similar ADJ O
+to ADP O
+the DET O
+task NOUN O
+- PUNCT O
+related VERB O
+response NOUN O
+itself PRON O
+( PUNCT O
+Fig PROPN O
+7B NUM O
+) PUNCT O
+. PUNCT O
+However ADV O
+, PUNCT O
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+in ADP O
+both CCONJ O
+amplitude NOUN O
+and CCONJ O
+temporal ADJ O
+jitter NOUN O
+can AUX O
+yield VERB O
+simulated VERB O
+time NOUN O
+- PUNCT O
+point NOUN O
+variability NOUN O
+time NOUN O
+series NOUN O
+that PRON O
+are AUX O
+similar ADJ O
+to ADP O
+the DET O
+fMRI NOUN B-AC
+variability NOUN O
+time NOUN O
+series NOUN O
+, PUNCT O
+depending VERB O
+on ADP O
+the DET O
+shape NOUN O
+of ADP O
+the DET O
+simulated VERB O
+impulse NOUN B-LF
+response NOUN I-LF
+function NOUN I-LF
+( PUNCT O
+IRF PROPN B-AC
+) PUNCT O
+used VERB O
+( PUNCT O
+Fig PROPN O
+6C NUM O
+, PUNCT O
+6D NUM O
+, PUNCT O
+6 NUM O
+G NOUN O
+and CCONJ O
+6H NOUN O
+) PUNCT O
+. PUNCT O
+Second ADJ O
+, PUNCT O
+the DET O
+sources NOUN O
+of ADP O
+noise NOUN O
+varied VERB O
+in ADP O
+how SCONJ O
+they PRON O
+affected VERB O
+the DET O
+mean ADJ O
+amplitude NOUN O
+of ADP O
+the DET O
+response NOUN O
+. PUNCT O
+
+GC NOUN B-AC
+= PUNCT O
+geriatric ADJ B-LF
+comanagement NOUN I-LF
+
+The DET O
+tumor NOUN O
+suppressor NOUN O
+function NOUN O
+of ADP O
+the DET O
+3 NUM O
+- PUNCT O
+phosphoinositide NOUN O
+phosphatase NOUN O
+PTEN PROPN O
+[ PUNCT O
+20,21 NUM O
+] PUNCT O
+, PUNCT O
+the DET O
+frequent ADJ O
+somatic ADJ O
+mutation NOUN O
+of ADP O
+phosphatidylinositol NOUN B-LF
+( PUNCT O
+PI PROPN B-AC
+) PUNCT O
+3 NUM O
+- PUNCT O
+kinase NOUN O
+in ADP O
+human ADJ O
+cancers NOUN O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+discovery NOUN O
+of ADP O
+a DET O
+germline ADJ O
+Akt2 PROPN O
+loss NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+function NOUN O
+mutation NOUN O
+in ADP O
+a DET O
+family NOUN O
+with ADP O
+autosomal ADJ O
+dominant ADJ O
+insulin NOUN O
+- PUNCT O
+resistant ADJ O
+diabetes NOUN O
+[ PUNCT O
+58 NUM O
+] PUNCT O
+underscore VERB O
+the DET O
+central ADJ O
+role NOUN O
+of ADP O
+this DET O
+pathway NOUN O
+in ADP O
+human ADJ O
+disease NOUN O
+. PUNCT O
+
+2,3,7,8 NUM O
+- PUNCT O
+tetrachlorodibenzo NOUN O
+- PUNCT O
+p NOUN O
+, PUNCT O
+p NOUN O
+- PUNCT O
+dioxin NOUN O
+( PUNCT O
+C12H4Cl4O2 PROPN O
+; PUNCT O
+p NOUN O
+- PUNCT O
+dioxin NOUN O
+, PUNCT O
+TCDD PROPN B-AC
+) PUNCT O
+has VERB O
+a DET O
+Log PROPN O
+P NOUN O
+of ADP O
+5.42 NUM O
+, PUNCT O
+a DET O
+vdWD NOUN B-AC
+of ADP O
+0.735 NUM O
+nm NOUN O
+and CCONJ O
+a DET O
+Log PROPN B-LF
+P NOUN I-LF
+/ SYM I-LF
+vdWD NOUN I-LF
+of ADP O
+7.38 NUM O
+nm-1 NUM O
+( PUNCT O
+Table PROPN O
+4 NUM O
+) PUNCT O
+. PUNCT O
+p NOUN O
+- PUNCT O
+dioxin NOUN O
+has VERB O
+a DET O
+calc NOUN O
+Lexternal PROPN O
+structure NOUN O
+/ SYM O
+Hpolar NOUN O
+group NOUN O
+ratio NOUN O
+of ADP O
+11.86 NUM O
+, PUNCT O
+and CCONJ O
+a DET O
+nl NOUN O
+calc NOUN O
+Lexternal PROPN O
+structure NOUN O
+/ SYM O
+Hpolar NOUN O
+group NOUN O
+quotient NOUN O
+of ADP O
+4.31 NUM O
+. PUNCT O
+8 NUM O
+- PUNCT O
+OH-2,3,7 NUM O
+- PUNCT O
+TriCDD NOUN O
+has VERB O
+a DET O
+calc NOUN O
+Lexternal PROPN O
+structure NOUN O
+/ SYM O
+Hpolar NOUN O
+group NOUN O
+ratio NOUN O
+of ADP O
+5.25 NUM O
+, PUNCT O
+and CCONJ O
+a DET O
+nl NOUN O
+calc NOUN O
+Lexternal PROPN O
+structure NOUN O
+/ SYM O
+Hpolar NOUN O
+group NOUN O
+quotient NOUN O
+of ADP O
+1.91 NUM O
+8 NUM O
+- PUNCT O
+O NOUN O
+- PUNCT O
+glucoronide-2,3,7 NOUN O
+- PUNCT O
+TriCDD NOUN O
+has VERB O
+a DET O
+calc NOUN O
+Lexternal PROPN O
+structure NOUN O
+/ SYM O
+Hpolar NOUN O
+group NOUN O
+ratio NOUN O
+of ADP O
+1.15 NUM O
+, PUNCT O
+and CCONJ O
+a DET O
+nl NOUN O
+calc NOUN O
+Lexternal PROPN O
+structure NOUN O
+/ SYM O
+Hpolar NOUN O
+group NOUN O
+quotient NOUN O
+of ADP O
+0.419 NUM O
+. PUNCT O
+
+CFH PROPN O
+mutations NOUN O
+have AUX O
+been AUX O
+described VERB O
+in ADP O
+association NOUN O
+with ADP O
+atypical ADJ B-LF
+haemolytic ADJ I-LF
+uraemic ADJ I-LF
+syndrome NOUN I-LF
+( PUNCT O
+aHUS PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+majority NOUN O
+of ADP O
+the DET O
+mutations NOUN O
+are AUX O
+missense ADJ O
+changes NOUN O
+that PRON O
+cluster VERB O
+in ADP O
+the DET O
+C PROPN O
+- PUNCT O
+terminal ADJ O
+region NOUN O
+and CCONJ O
+impair VERB O
+the DET O
+ability NOUN O
+of ADP O
+factor NOUN O
+H PROPN O
+to PART O
+regulate VERB O
+surface NOUN O
+- PUNCT O
+bound VERB O
+C3b NOUN O
+. PUNCT O
+
+PD-1 PROPN B-AC
+, PUNCT O
+Programmed ADJ B-LF
+cell NOUN I-LF
+death NOUN I-LF
+protein NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+PD PROPN B-AC
+- PUNCT B-AC
+L1 PROPN B-AC
+, PUNCT O
+PD-1 PROPN B-LF
+ligand NOUN I-LF
+1 NUM O
+; PUNCT O
+RM PROPN O
+, PUNCT O
+repeated VERB O
+measures NOUN O
+; PUNCT O
+TCR PROPN B-AC
+, PUNCT O
+T PROPN B-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+. PUNCT O
+
+Four NUM O
+different ADJ O
+centrifugation NOUN B-LF
+protocols NOUN I-LF
+were AUX O
+evaluated VERB O
+using VERB O
+urine NOUN O
+samples NOUN O
+with ADP O
+preservative NOUN O
+of ADP O
+cancer NOUN O
+patients NOUN O
+and CCONJ O
+HVs NOUN B-AC
+. PUNCT O
+A X O
+: PUNCT O
+Total ADJ O
+DNA NOUN O
+concentrations NOUN O
+analyzed VERB O
+with ADP O
+Qubit PROPN O
+fluorometer NOUN O
+and CCONJ O
+ddPCR NOUN B-AC
+. PUNCT O
+B NOUN O
+: PUNCT O
+Amount NOUN O
+of ADP O
+cfDNA NOUN B-AC
+and CCONJ O
+gDNA NOUN B-AC
+determined VERB O
+with ADP O
+the DET O
+FragmentAnalyzer PROPN O
+. PUNCT O
+cfDNA NOUN B-AC
+= PUNCT O
+circulating VERB B-LF
+cell NOUN I-LF
+- PUNCT I-LF
+free ADJ I-LF
+DNA NOUN I-LF
+, PUNCT O
+CP PROPN B-AC
+I NOUN O
+= PUNCT O
+4,000 NUM O
+g NOUN O
+10min NUM O
+, PUNCT O
+CP PROPN B-AC
+II PROPN O
+= PUNCT O
+3,000 NUM O
+g NOUN O
+15min NUM O
+, PUNCT O
+CP PROPN B-AC
+III PROPN O
+= PUNCT O
+2,680 NUM O
+g NOUN O
+10min NUM O
+, PUNCT O
+CP PROPN B-AC
+IV NOUN O
+= PUNCT O
+750 NUM O
+g NOUN O
+10min NUM O
+, PUNCT O
+ddPCR NOUN B-AC
+= PUNCT O
+digital ADJ B-LF
+droplet NOUN I-LF
+PCR NOUN I-LF
+, PUNCT O
+gDNA NOUN B-AC
+= PUNCT O
+genomic ADJ B-LF
+DNA NOUN I-LF
+, PUNCT O
+HV NOUN B-AC
+= PUNCT O
+healthy ADJ B-LF
+volunteer NOUN I-LF
+. PUNCT O
+
+Expected VERB O
+genetic ADJ B-LF
+advance NOUN I-LF
+σ2p(GA)=K×σ2p×h2B NOUN B-AC
+
+We PRON O
+will AUX O
+define VERB O
+each PRON O
+of ADP O
+the DET O
+performance NOUN O
+measures NOUN O
+in ADP O
+turn NOUN O
+, PUNCT O
+after ADP O
+first ADV O
+defining VERB O
+true ADJ B-LF
+positives NOUN I-LF
+( PUNCT O
+TP NOUN B-AC
+) PUNCT O
+, PUNCT O
+true ADJ B-LF
+negatives NOUN I-LF
+( PUNCT O
+TN PROPN B-AC
+) PUNCT O
+, PUNCT O
+false ADJ B-LF
+positives NOUN I-LF
+( PUNCT O
+FP NOUN B-AC
+) PUNCT O
+and CCONJ O
+false ADJ B-LF
+negatives NOUN I-LF
+( PUNCT O
+FN NOUN B-AC
+) PUNCT O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+Addition NOUN O
+of ADP O
+antioxidative ADJ O
+superoxide NOUN O
+scavenger NOUN O
+Tiron PROPN O
+( PUNCT O
+10 NUM O
+mM NOUN O
+) PUNCT O
+decreased VERB O
+H NOUN B-AC
+/ SYM B-AC
+R NOUN B-AC
+- PUNCT O
+induced VERB O
+apoptosis NOUN O
+of ADP O
+control NOUN O
+cells NOUN O
+to ADP O
+60 NUM O
+% NOUN O
+( PUNCT O
+Fig PROPN O
+1E NUM O
+and CCONJ O
+1F NOUN O
+) PUNCT O
+as ADP O
+well ADV O
+as ADP O
+apoptosis NOUN O
+of ADP O
+mitoNEET NOUN O
+- PUNCT O
+KD NOUN B-AC
+cells NOUN O
+to ADP O
+the DET O
+same ADJ O
+level NOUN O
+indicating VERB O
+that PRON O
+mitoNEET NOUN O
+- PUNCT O
+counteracted VERB O
+apoptosis NOUN O
+was AUX O
+caused VERB O
+by ADP O
+superoxide NOUN O
+radicals NOUN O
+and CCONJ O
+was AUX O
+consequently ADV O
+related VERB O
+to ADP O
+reactive ADJ B-LF
+oxygen NOUN I-LF
+species NOUN I-LF
+( PUNCT O
+ROS PROPN B-AC
+) PUNCT O
+. PUNCT O
+To PART O
+assess VERB O
+the DET O
+role NOUN O
+of ADP O
+glutathione NOUN B-LF
+redox NOUN O
+system NOUN O
+in ADP O
+our PRON O
+H NOUN B-AC
+/ SYM B-AC
+R NOUN B-AC
+model NOUN O
+, PUNCT O
+we PRON O
+used VERB O
+glutathione NOUN B-LF
+reduced VERB O
+ethyl NOUN O
+ester NOUN O
+( PUNCT O
+GSH PROPN B-AC
+- PUNCT B-AC
+MEE PROPN B-AC
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+1E NUM O
+and CCONJ O
+1 NUM O
+G NOUN O
+) PUNCT O
+, PUNCT O
+an DET O
+esterified VERB O
+glutathione NOUN B-LF
+compound NOUN O
+that PRON O
+is AUX O
+readily ADV O
+transported VERB O
+into ADP O
+the DET O
+cell NOUN O
+and CCONJ O
+increases VERB O
+intracellularly ADV O
+the DET O
+bioavailability NOUN O
+of ADP O
+glutathione NOUN B-LF
+[ PUNCT O
+27 NUM O
+] PUNCT O
+. PUNCT O
+
+TB NOUN B-AC
+, PUNCT O
+tuberculosis NOUN B-LF
+. PUNCT O
+
+Among ADP O
+patients NOUN O
+aged VERB O
+60 NUM O
+to PART O
+69 NUM O
+in ADP O
+G2 PROPN O
+, PUNCT O
+those PRON O
+without ADP O
+previous ADJ O
+CVD NOUN B-AC
+were AUX O
+predicted VERB O
+to PART O
+live VERB O
+a DET O
+further ADJ O
+22.1 NUM O
+years NOUN O
+( PUNCT O
+16.1 NUM O
+quality NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+years NOUN I-LF
+[ PUNCT O
+QALYs NOUN B-AC
+] PUNCT O
+) PUNCT O
+and CCONJ O
+those PRON O
+with ADP O
+CVD NOUN B-AC
+a DET O
+further ADJ O
+18.6 NUM O
+years NOUN O
+( PUNCT O
+11.8 NUM O
+QALYs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+The DET O
+routine ADJ O
+clinical ADJ O
+DTI NOUN O
+was AUX O
+a DET O
+single ADJ O
+- ADJ O
+shot NOUN O
+multi ADJ O
+- ADJ O
+level ADJ O
+echo NOUN O
+planar NOUN O
+sequence NOUN O
+with ADP O
+40 NUM O
+slices NOUN O
+( PUNCT O
+repetition NOUN B-LF
+time NOUN I-LF
+( PUNCT O
+TR NOUN B-AC
+) PUNCT O
+8000 NUM O
+msec NOUN O
+, PUNCT O
+echo NOUN B-LF
+time NOUN I-LF
+( PUNCT O
+TE PROPN B-AC
+) PUNCT O
+88 NUM O
+msec NOUN O
+, PUNCT O
+inversion NOUN O
+Time NOUN O
+( PUNCT O
+IT PROPN O
+): PUNCT O
+-1 NUM O
+msec NOUN O
+, PUNCT O
+field NOUN B-LF
+of ADP I-LF
+view NOUN I-LF
+( PUNCT O
+FOV PROPN B-AC
+) PUNCT O
+25 NUM O
+x SYM O
+30 NUM O
+cm NOUN O
+, PUNCT O
+30 NUM O
+gradient NOUN O
+directions NOUN O
+at ADP O
+b NOUN O
+values NOUN O
+of ADP O
+1000 NUM O
+mm2 NOUN O
+/ NOUN O
+s NOUN O
+, PUNCT O
+5 NUM O
+gradient NOUN O
+directions NOUN O
+at ADP O
+b NOUN O
+= SYM O
+0 NUM O
+mm2 NOUN O
+/ NOUN O
+s NOUN O
+, PUNCT O
+voxel NOUN O
+sizes NOUN O
+: PUNCT O
+2.00 NUM O
+, PUNCT O
+2.00 NUM O
+, PUNCT O
+2.00 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+incidence NOUN O
+density NOUN O
+sampling NOUN O
+design NOUN O
+assures VERB O
+equal ADJ O
+time NOUN O
+during ADP O
+which PRON O
+case NOUN O
+and CCONJ O
+control NOUN O
+subjects NOUN O
+are AUX O
+at ADP O
+risk NOUN O
+for ADP O
+the DET O
+exposures NOUN O
+of ADP O
+interest NOUN O
+and CCONJ O
+generates VERB O
+odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+ORs NOUN B-AC
+) PUNCT O
+interpretable ADJ O
+as ADP O
+unbiased ADJ O
+estimates NOUN O
+of ADP O
+incidence NOUN O
+rate NOUN O
+ratios NOUN O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+Wolfram PROPN B-LF
+syndrome NOUN I-LF
+( PUNCT O
+WS PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+genetic ADJ O
+disorder NOUN O
+characterized VERB O
+by ADP O
+diabetes NOUN O
+insipidus NOUN O
+, PUNCT O
+diabetes NOUN O
+mellitus NOUN O
+, PUNCT O
+optic ADJ O
+atrophy NOUN O
+, PUNCT O
+deafness NOUN O
+, PUNCT O
+and CCONJ O
+brain NOUN O
+atrophy NOUN O
+. PUNCT O
+
+Blood NOUN O
+spots NOUN O
+were AUX O
+obtained VERB O
+at ADP O
+screening NOUN O
+and CCONJ O
+stored VERB O
+on ADP O
+filter NOUN O
+paper NOUN O
+for ADP O
+polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+PCR PROPN B-AC
+) PUNCT O
+genotyping NOUN O
+. PUNCT O
+
+However ADV O
+, PUNCT O
+in ADP O
+cases NOUN O
+on ADP O
+noncomplementers NOUN O
+( PUNCT O
+e.g. X O
+, PUNCT O
+Hs PROPN B-AC
+- PUNCT O
+CDC14A PROPN O
+) PUNCT O
+, PUNCT O
+only ADV O
+two NUM O
+yeast NOUN O
+spores NOUN O
+( PUNCT O
+carrying VERB O
+the DET O
+wild ADJ O
+- PUNCT O
+type NOUN O
+yeast NOUN O
+allele NOUN O
+) PUNCT O
+survive VERB O
+on ADP O
+YPD PROPN O
+and CCONJ O
+fail VERB O
+to PART O
+grow VERB O
+on ADP O
+YPD PROPN O
++ SYM O
+G418 PROPN O
+but CCONJ O
+grow VERB O
+on ADP O
+5 NUM O
+- PUNCT O
+FOA PROPN O
+, PUNCT O
+indicating VERB O
+plasmid NOUN O
+loss NOUN O
+. PUNCT O
+( PUNCT O
+C NOUN O
+) PUNCT O
+Each DET O
+confirmed VERB O
+humanized ADJ O
+haploid ADJ O
+yeast NOUN O
+strain NOUN O
+was AUX O
+assayed VERB O
+for ADP O
+growth NOUN O
+defects NOUN O
+to PART O
+quantify VERB O
+the DET O
+replaceability NOUN O
+. PUNCT O
+5 NUM O
+- PUNCT O
+FOA PROPN O
+, PUNCT O
+5 NUM O
+- PUNCT O
+flouroorotic ADJ O
+acid NOUN O
+; PUNCT O
+CDC14A PROPN O
+, PUNCT O
+human ADJ O
+dual ADJ O
+specificity NOUN O
+protein NOUN O
+phosphatase NOUN O
+CDC14A PROPN O
+gene NOUN O
+; PUNCT O
+hetKO PROPN B-AC
+, PUNCT O
+heterozygous ADJ B-LF
+diploid NOUN I-LF
+knockout NOUN I-LF
+, PUNCT O
+Hs PROPN B-AC
+, PUNCT O
+H. PROPN O
+sapiens ADJ O
+; PUNCT O
+SD PROPN O
+, PUNCT O
+synthetic ADJ O
+defined VERB O
+; PUNCT O
+Ura PROPN O
+, PUNCT O
+uracil NOUN O
+; PUNCT O
+YIPF5 PROPN O
+, PUNCT O
+human ADJ O
+YIPF5 PROPN O
+gene NOUN O
+; PUNCT O
+YPD PROPN O
+, PUNCT O
+yeast NOUN O
+extract NOUN O
+peptone NOUN O
+dextrose NOUN O
+. PUNCT O
+
+Despite SCONJ O
+evidence NOUN O
+of ADP O
+ANC PROPN B-AC
+attendance NOUN O
+and CCONJ O
+administration NOUN O
+of ADP O
+intermittent ADJ B-LF
+preventive ADJ I-LF
+treatment NOUN I-LF
+with ADP I-LF
+sulfadoxine NOUN I-LF
+- PUNCT I-LF
+pyrimethamine NOUN I-LF
+( PUNCT O
+IPTp PROPN B-AC
+- PUNCT B-AC
+SP PROPN B-AC
+) PUNCT O
+dosage NOUN O
+during ADP O
+these DET O
+visits NOUN O
+, PUNCT O
+malaria NOUN O
+positivity NOUN O
+rate NOUN O
+was AUX O
+still ADV O
+high ADJ O
+among ADP O
+pregnant ADJ O
+women NOUN O
+and CCONJ O
+children NOUN O
+below ADP O
+five NUM O
+years NOUN O
+in ADP O
+these DET O
+two NUM O
+rural ADJ O
+counties NOUN O
+. PUNCT O
+
+The DET O
+STOP PROPN O
+TB PROPN B-AC
+Partnership PROPN O
+is AUX O
+an DET O
+international ADJ O
+initiative NOUN O
+involving VERB O
+several ADJ O
+agencies NOUN O
+seeking VERB O
+to PART O
+combat VERB O
+the DET O
+rise NOUN O
+of ADP O
+tuberculosis NOUN B-LF
+
+Thus ADV O
+, PUNCT O
+we PRON O
+expressed VERB O
+carnitine NOUN O
+palmitoyltransferase NOUN O
+1AM PROPN O
+( PUNCT O
+CPT1AM PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+permanently ADV B-LF
+active ADJ I-LF
+mutant ADJ I-LF
+form NOUN I-LF
+of ADP I-LF
+CPT1A PROPN I-LF
+( PUNCT O
+the DET O
+rate NOUN O
+- PUNCT O
+limiting VERB O
+enzyme NOUN O
+in ADP O
+FAO PROPN B-AC
+) PUNCT O
+, PUNCT O
+in ADP O
+a DET O
+rat NOUN O
+brown ADJ O
+adipocyte NOUN O
+( PUNCT O
+rBA PROPN B-AC
+) PUNCT O
+cell NOUN O
+line NOUN O
+through ADP O
+adenoviral ADJ O
+infection NOUN O
+. PUNCT O
+
+AUD PROPN B-AC
+, PUNCT O
+Australian ADJ B-LF
+dollar NOUN I-LF
+; PUNCT O
+IHD PROPN B-AC
+, PUNCT O
+ischemic ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+SEIFA PROPN B-AC
+, PUNCT O
+Socio ADJ B-LF
+- PUNCT I-LF
+Economic ADJ I-LF
+Indexes NOUN I-LF
+for ADP I-LF
+Areas PROPN I-LF
+. PUNCT O
+
+We PRON O
+chose VERB O
+models NOUN O
+with ADP O
+small ADJ O
+numbers NOUN O
+of ADP O
+features NOUN O
+, PUNCT O
+with ADP O
+performance NOUN O
+at ADP O
+or CCONJ O
+no DET O
+more ADJ O
+than ADP O
+1 NUM O
+standard ADJ O
+error NOUN O
+away ADV O
+from ADP O
+best ADJ O
+test NOUN O
+performance NOUN O
+, PUNCT O
+and CCONJ O
+with ADP O
+interpretable ADJ O
+outcomes NOUN O
+— PUNCT O
+for ADP O
+example NOUN O
+, PUNCT O
+scores NOUN O
+generated VERB O
+by ADP O
+a DET O
+boosted VERB O
+decision NOUN O
+tree NOUN O
+or CCONJ O
+logistic ADJ B-LF
+regression NOUN I-LF
+( PUNCT O
+LR PROPN B-AC
+) PUNCT O
+approach NOUN O
+. PUNCT O
+
+Two NUM O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+( PUNCT O
+qPCR NOUN B-AC
+) PUNCT O
+assays NOUN O
+were AUX O
+developed VERB O
+for ADP O
+ultra ADJ O
+- PUNCT O
+sensitive ADJ O
+detection NOUN O
+of ADP O
+Plasmodium PROPN O
+falciparum NOUN O
+, PUNCT O
+targeting VERB O
+the DET O
+high ADJ O
+- PUNCT O
+copy NOUN O
+telomere NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+repetitive ADJ I-LF
+element NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+TARE-2 PROPN B-AC
+, PUNCT O
+∼250 NUM O
+copies NOUN O
+/ SYM O
+genome NOUN O
+) PUNCT O
+and CCONJ O
+the DET O
+var NOUN O
+gene NOUN O
+acidic ADJ O
+terminal ADJ O
+sequence NOUN O
+( PUNCT O
+varATS NOUN B-AC
+, PUNCT O
+59 NUM O
+copies NOUN O
+/ SYM O
+genome NOUN O
+) PUNCT O
+. PUNCT O
+
+NZ PROPN B-AC
+cohort NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+376 NUM O
+) PUNCT O
+consisted VERB O
+of ADP O
+94 NUM O
+% NOUN O
+Caucasians PROPN O
+while SCONJ O
+the DET O
+US PROPN B-AC
+cohort NOUN O
+consisted VERB O
+of ADP O
+African PROPN B-LF
+Americans PROPN I-LF
+( PUNCT O
+AA PROPN B-AC
+) PUNCT O
+, PUNCT O
+n NOUN O
+= SYM O
+202 NUM O
+, PUNCT O
+and CCONJ O
+European PROPN B-LF
+Americans PROPN I-LF
+( PUNCT O
+EA PROPN B-AC
+) PUNCT O
+, PUNCT O
+n NOUN O
+= SYM O
+232 NUM O
+. PUNCT O
+
+Yet CCONJ O
+, PUNCT O
+beneath ADP O
+all DET O
+these DET O
+data NOUN O
+were AUX O
+important ADJ O
+limitations NOUN O
+that PRON O
+undermined VERB O
+the DET O
+evidence NOUN O
+: PUNCT O
+inevitable ADJ O
+measurement NOUN O
+errors NOUN O
+due ADJ O
+to PART O
+dietary ADJ O
+assessment NOUN O
+via ADP O
+subjective ADJ O
+report NOUN O
+, PUNCT O
+differences NOUN O
+in ADP O
+exposure NOUN O
+assessment NOUN O
+window NOUN O
+, PUNCT O
+predominantly ADV O
+white ADJ O
+study NOUN O
+populations NOUN O
+, PUNCT O
+and CCONJ O
+inability NOUN O
+to PART O
+disentangle VERB O
+potentially ADV O
+distinct ADJ O
+health NOUN O
+effects NOUN O
+of ADP O
+individual ADJ O
+PUFAs PROPN B-AC
+. PUNCT O
+Indeed ADV O
+, PUNCT O
+except SCONJ O
+for ADP O
+the DET O
+essential ADJ O
+fatty NOUN O
+acids NOUN O
+alpha NOUN B-LF
+- PUNCT I-LF
+linolenic ADJ I-LF
+acid NOUN I-LF
+( PUNCT O
+ALA PROPN B-AC
+) PUNCT O
+and CCONJ O
+LA PROPN B-AC
+, PUNCT O
+levels NOUN O
+of ADP O
+circulating VERB O
+long ADJ O
+- PUNCT O
+chain NOUN O
+PUFA PROPN B-AC
+derivatives NOUN O
+are AUX O
+functions NOUN O
+of ADP O
+both CCONJ O
+exogenous ADJ O
+( PUNCT O
+via ADP O
+dietary ADJ O
+intake NOUN O
+) PUNCT O
+and CCONJ O
+endogenous ADJ O
+( PUNCT O
+via ADP O
+lipogenesis NOUN O
+) PUNCT O
+origins NOUN O
+, PUNCT O
+with ADP O
+unique ADJ O
+biochemical ADJ O
+properties NOUN O
+and CCONJ O
+metabolic ADJ O
+effects NOUN O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+. PUNCT O
+
+* PUNCT O
+CI NOUN B-AC
+: PUNCT O
+Confidence NOUN B-LF
+interval NOUN I-LF
+
+AtbR PROPN B-AC
+clones NOUN B-AC
+, PUNCT O
+antibiotic ADJ B-LF
+resistant ADJ I-LF
+clones NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+proteins NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+To PART O
+more ADV O
+fully ADV O
+explore VERB O
+biomarkers NOUN O
+associated VERB O
+with ADP O
+HIV PROPN O
+reactivation NOUN O
+after ADP O
+the DET O
+interruption NOUN O
+of ADP O
+ART PROPN B-AC
+, PUNCT O
+we PRON O
+also ADV O
+accessed VERB O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PBMCs PROPN B-AC
+) PUNCT O
+from ADP O
+a DET O
+previously ADV O
+described VERB O
+case NOUN O
+of ADP O
+an DET O
+HIV PROPN O
+- PUNCT O
+infected VERB O
+adult NOUN O
+who PRON O
+underwent VERB O
+an DET O
+allogenic ADJ O
+hematopoietic ADJ O
+stem NOUN O
+- PUNCT O
+cell NOUN O
+transplantation NOUN O
+( PUNCT O
+HSCT PROPN B-AC
+Participant PROPN O
+B PROPN O
+) PUNCT O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+Considering VERB O
+the DET O
+fact NOUN O
+that SCONJ O
+nandrolone NOUN B-LF
+decanoate NOUN I-LF
+( PUNCT O
+ND PROPN B-AC
+) PUNCT O
+is AUX O
+one NUM O
+of ADP O
+the DET O
+most ADV O
+commonly ADV O
+used VERB O
+AAS PROPN B-AC
+, PUNCT O
+the DET O
+aim NOUN O
+of ADP O
+this DET O
+study NOUN O
+was AUX O
+to PART O
+evaluate VERB O
+the DET O
+effects NOUN O
+of ADP O
+chronic ADJ O
+ND PROPN B-AC
+administration NOUN O
+and CCONJ O
+exercise NOUN O
+( PUNCT O
+swimming NOUN O
+protocol NOUN O
+) PUNCT O
+on ADP O
+behavioral ADJ O
+changes NOUN O
+in ADP O
+rats NOUN O
+by ADP O
+means NOUN O
+of ADP O
+specific ADJ O
+behavioral ADJ O
+tests NOUN O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+on ADP O
+hippocampal ADJ O
+PV NOUN B-AC
+content NOUN O
+. PUNCT O
+
+Cdk PROPN B-AC
+, PUNCT O
+cyclin NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+kinase NOUN I-LF
+; PUNCT O
+CycD PROPN B-AC
+, PUNCT O
+Cyclin NOUN B-LF
+D PROPN I-LF
+; PUNCT O
+E2F NOUN B-AC
+, PUNCT O
+E2F NOUN B-LF
+transcription NOUN I-LF
+factor NOUN I-LF
+; PUNCT O
+FAIRE PROPN B-AC
+, PUNCT O
+formaldehyde NOUN B-LF
+- PUNCT I-LF
+assisted VERB I-LF
+isolation NOUN I-LF
+of ADP I-LF
+regulatory ADJ I-LF
+elements NOUN I-LF
+; PUNCT O
+FAIRE PROPN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+FAIRE PROPN B-LF
+sequencing NOUN I-LF
+; PUNCT O
+MA PROPN O
+plot NOUN O
+, PUNCT O
+scatter NOUN O
+plot NOUN O
+onto ADP O
+M NOUN O
+( PUNCT O
+log NOUN O
+ratio NOUN O
+) PUNCT O
+and CCONJ O
+A NOUN O
+( PUNCT O
+mean ADJ O
+average NOUN O
+) PUNCT O
+scales NOUN O
+; PUNCT O
+RNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+. PUNCT O
+
+Circulating VERB O
+levels NOUN O
+of ADP O
+platelet NOUN B-LF
+factor NOUN I-LF
+4 NUM I-LF
+( PUNCT O
+PF4 PROPN B-AC
+) PUNCT O
+were AUX O
+substantially ADV O
+elevated ADJ O
+in ADP O
+COVID-19 PROPN B-AC
+patients NOUN O
+when SCONJ O
+compared VERB O
+to ADP O
+both CCONJ O
+hospitalised ADJ O
+( PUNCT O
+HoC PROPN O
+) PUNCT O
+and CCONJ O
+healthy ADJ O
+controls NOUN O
+( PUNCT O
+HeC PROPN O
+) PUNCT O
+( PUNCT O
+p NOUN O
+= SYM O
+0.012 NUM O
+and CCONJ O
+p NOUN O
+= SYM O
+0.0033 NUM O
+, PUNCT O
+respectively ADV O
+; PUNCT O
+Fig NOUN O
+3A NUM O
+) PUNCT O
+. PUNCT O
+Nonetheless ADV O
+, PUNCT O
+circulating VERB O
+PF4 PROPN B-AC
+levels NOUN O
+could AUX O
+not PART O
+differentiate VERB O
+between ADP O
+severe ADJ O
+and CCONJ O
+nonsevere ADJ O
+COVID-19 PROPN B-AC
+patient NOUN O
+cohorts NOUN O
+( PUNCT O
+p NOUN O
+= SYM O
+0.85 NUM O
+) PUNCT O
+. PUNCT O
+
+ApoE NOUN O
+= PUNCT O
+apolipoprotein NOUN O
+E NOUN O
+; PUNCT O
+CTRL NOUN B-AC
+= PUNCT O
+control NOUN O
+; PUNCT O
+HF NOUN B-AC
+= PUNCT O
+high ADJ B-LF
+- NOUN I-LF
+fat NOUN I-LF
+; PUNCT O
+WT NOUN B-AC
+= PUNCT O
+wild NOUN B-LF
+- NOUN I-LF
+type NOUN I-LF
+. PUNCT O
+
+Lactate NOUN B-LF
+Dehydrogenase NOUN I-LF
+L NOUN O
+- NOUN O
+P PROPN O
+( PUNCT O
+LDH PROPN B-AC
+) PUNCT O
+activity NOUN O
+was AUX O
+measured VERB O
+by ADP O
+its PRON O
+conversion NOUN O
+of ADP O
+L NOUN O
+- NOUN O
+lactate NOUN O
+to ADP O
+pyruvate NOUN O
+in ADP O
+the DET O
+presence NOUN O
+of ADP O
+nicotinamide NOUN O
+adenine NOUN O
+dinucleotide NOUN O
+based VERB O
+on ADP O
+the DET O
+method NOUN O
+of ADP O
+Amador PROPN O
+et X O
+al NOUN O
+. PUNCT O
+[ PUNCT O
+20 NUM O
+] PUNCT O
+. PUNCT O
+
+Human ADJ O
+semen NOUN O
+has VERB O
+the DET O
+potential NOUN O
+to PART O
+modulate VERB O
+the DET O
+epithelial ADJ O
+mucosal ADJ O
+tissues NOUN O
+it PRON O
+contacts VERB O
+, PUNCT O
+as SCONJ O
+seminal ADJ B-LF
+plasma NOUN I-LF
+( PUNCT O
+SP PROPN B-AC
+) PUNCT O
+is AUX O
+recognized VERB O
+to PART O
+contain VERB O
+both CCONJ O
+pro- ADJ O
+and CCONJ O
+anti ADJ O
+- ADJ O
+barrier NOUN O
+components NOUN O
+, PUNCT O
+yet CCONJ O
+its PRON O
+effects NOUN O
+on ADP O
+epithelial ADJ O
+barrier NOUN O
+function NOUN O
+are AUX O
+largely ADV O
+unknown ADJ O
+. PUNCT O
+
+One NUM O
+potential ADJ O
+link NOUN O
+between ADP O
+RP PROPN B-AC
+expression NOUN O
+and CCONJ O
+S NOUN O
+- PUNCT O
+phase NOUN O
+is AUX O
+the DET O
+ultradian ADJ O
+yeast NOUN B-LF
+metabolic ADJ I-LF
+cycle NOUN I-LF
+( PUNCT O
+YMC PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+can AUX O
+be AUX O
+synchronized VERB O
+in ADP O
+bulk ADJ O
+cultures NOUN O
+through ADP O
+nutrient NOUN O
+deprivation NOUN O
+and CCONJ O
+has AUX O
+recently ADV O
+been AUX O
+reported VERB O
+in ADP O
+asynchronous ADJ O
+, PUNCT O
+nutrient NOUN O
+- PUNCT O
+replete ADJ O
+cultures NOUN O
+[ X O
+59–62 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+the DET O
+human ADJ O
+neocortex NOUN O
+, PUNCT O
+single ADJ O
+excitatory ADJ O
+pyramidal ADJ O
+cells NOUN O
+can AUX O
+elicit VERB O
+very ADV B-LF
+large ADJ I-LF
+glutamatergic ADJ I-LF
+EPSPs NOUN I-LF
+( PUNCT O
+VLEs NOUN B-AC
+) PUNCT O
+in ADP O
+inhibitory ADJ O
+GABAergic ADJ O
+interneurons NOUN O
+capable ADJ O
+of ADP O
+triggering VERB O
+their PRON O
+firing NOUN O
+with ADP O
+short ADJ O
+( PUNCT O
+3–5 NUM O
+ms NOUN O
+) PUNCT O
+delay NOUN O
+. PUNCT O
+
+BCR NOUN B-AC
+, PUNCT O
+biochemical ADJ B-LF
+recurrence NOUN I-LF
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+combination NOUN O
+therapy NOUN O
+increased VERB O
+the DET O
+expression NOUN O
+of ADP O
+mammalian ADJ B-LF
+target NOUN I-LF
+of ADP I-LF
+rapamycin NOUN I-LF
+( PUNCT O
+mTOR NOUN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+negative ADJ O
+regulator NOUN O
+of ADP O
+functional ADJ O
+autophagy NOUN O
+, PUNCT O
+in ADP O
+both DET O
+cell NOUN O
+lines NOUN O
+. PUNCT O
+
+EBV PROPN B-AC
+, PUNCT O
+Epstein PROPN B-LF
+– PUNCT I-LF
+Barr PROPN I-LF
+virus NOUN I-LF
+; PUNCT O
+KSHV PROPN B-AC
+, PUNCT O
+Kaposi PROPN B-LF
+’s PART I-LF
+sarcoma NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+herpesvirus NOUN I-LF
+; PUNCT O
+NMD PROPN B-AC
+, PUNCT O
+nonsense NOUN B-LF
+- PUNCT I-LF
+mediated VERB I-LF
+decay NOUN I-LF
+; PUNCT O
+qRT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+, PUNCT O
+quantitative ADJ B-LF
+reverse ADJ I-LF
+transcription NOUN I-LF
+PCR NOUN I-LF
+; PUNCT O
+siRNA NOUN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+. PUNCT O
+
+IGFBP-1 PROPN B-AC
+, PUNCT O
+insulin NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+growth NOUN I-LF
+factor NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+PCSK9 PROPN B-AC
+, PUNCT O
+proprotein NOUN B-LF
+convertase NOUN I-LF
+subtilisin NOUN I-LF
+/ SYM I-LF
+kexin NOUN I-LF
+type NOUN I-LF
+9 NUM I-LF
+; PUNCT O
+PD PROPN B-AC
+, PUNCT O
+Parkinson PROPN B-LF
+’s PART I-LF
+disease NOUN I-LF
+; PUNCT O
+RFU PROPN B-AC
+, PUNCT O
+relative ADJ B-LF
+fluorescence NOUN I-LF
+unit NOUN I-LF
+. PUNCT O
+
+The DET O
+final ADJ O
+models NOUN O
+considered VERB O
+the DET O
+following ADJ O
+variables NOUN O
+: PUNCT O
+Clinical ADJ O
+presentation NOUN O
+( PUNCT O
+STEMI PROPN B-AC
+or CCONJ O
+NSTE PROPN B-AC
+- ADJ B-AC
+ACS PROPN B-AC
+) PUNCT O
+, PUNCT O
+age NOUN O
+, PUNCT O
+gender NOUN O
+, PUNCT O
+weight NOUN O
+, PUNCT O
+presence NOUN O
+of ADP O
+diabetes NOUN O
+mellitus NOUN O
+, PUNCT O
+presence NOUN O
+of ADP O
+arterial ADJ O
+hypertension NOUN O
+, PUNCT O
+presence NOUN O
+of ADP O
+hyperlipidaemia NOUN O
+, PUNCT O
+familiar ADJ O
+history NOUN O
+of ADP O
+coronary ADJ B-LF
+heart NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CHD PROPN B-AC
+) PUNCT O
+, PUNCT O
+current ADJ O
+or CCONJ O
+prior ADJ O
+smoking NOUN O
+, PUNCT O
+history NOUN O
+of ADP O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+COPD PROPN B-AC
+) PUNCT O
+, PUNCT O
+site NOUN O
+of ADP O
+antiplatelet ADJ O
+loading NOUN O
+therapy NOUN O
+, PUNCT O
+presence NOUN O
+of ADP O
+atrial ADJ O
+fibrillation NOUN O
+, PUNCT O
+active ADJ O
+bleeding NOUN O
+at ADP O
+admission NOUN O
+, PUNCT O
+history NOUN O
+of ADP O
+stroke NOUN O
+or CCONJ O
+transient ADJ B-LF
+ischemic ADJ I-LF
+attack NOUN I-LF
+( PUNCT O
+TIA PROPN B-AC
+) PUNCT O
+, PUNCT O
+history NOUN O
+of ADP O
+intracranial ADJ O
+haemorrhage NOUN O
+, PUNCT O
+planned VERB O
+operation NOUN O
+and CCONJ O
+peri ADJ O
+- ADJ O
+interventional ADJ O
+anticoagulation ADJ O
+treatment NOUN O
+regimen NOUN O
+regimen NOUN O
+( PUNCT O
+only ADV O
+at ADP O
+discharge NOUN O
+) PUNCT O
+. PUNCT O
+
+AF PROPN B-AC
+: PUNCT O
+atrial ADJ B-LF
+fibrillation NOUN I-LF
+; PUNCT O
+AFL PROPN B-AC
+: PUNCT O
+atrial ADJ B-LF
+flutter NOUN I-LF
+; PUNCT O
+NOAC PROPN B-AC
+: PUNCT O
+non ADJ O
+- ADJ O
+vitamin ADJ O
+K PROPN O
+oral ADJ O
+anticoagulant NOUN O
+; PUNCT O
+TEE PROPN B-AC
+: PUNCT O
+trans ADJ B-LF
+- ADJ I-LF
+esophageal ADJ I-LF
+echocardiography NOUN I-LF
+. PUNCT O
+
+Vascular ADJ B-LF
+smooth ADJ I-LF
+muscle NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+VSMCs NOUN B-AC
+) PUNCT O
+are AUX O
+essential ADJ O
+regulators NOUN O
+of ADP O
+vascular ADJ O
+function NOUN O
+[ X O
+1,2 NUM O
+] PUNCT O
+. PUNCT O
+
+FL PROPN O
+- PUNCT O
+p53 NOUN O
+, PUNCT O
+full ADJ O
+- PUNCT O
+length NOUN O
+p53 NOUN O
+; PUNCT O
+PTC PROPN B-AC
+, PUNCT O
+premature ADJ B-LF
+termination NOUN I-LF
+codon NOUN I-LF
+; PUNCT O
+RNA NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT O
+TR NOUN O
+- PUNCT O
+p53 NOUN O
+, PUNCT O
+truncated VERB O
+p53 NOUN O
+. PUNCT O
+
+Immunosenescence NOUN O
+with ADP O
+exhaustion NOUN O
+of ADP O
+plasmacytoid ADJ O
+dendritic ADJ O
+cells NOUN O
+, PUNCT O
+natural ADJ B-LF
+killer NOUN I-LF
+( PUNCT O
+NK PROPN B-AC
+) PUNCT O
+cells NOUN O
+and CCONJ O
+cytotoxic ADJ O
+CD8 PROPN O
++ NOUN O
+T PROPN O
+cells NOUN O
+, PUNCT O
+which PRON O
+form VERB O
+the DET O
+frontline NOUN O
+of ADP O
+cellular ADJ O
+innate ADJ O
+and CCONJ O
+adaptive ADJ O
+anti ADJ O
+- ADJ O
+viral ADJ O
+immune ADJ O
+defense NOUN O
+, PUNCT O
+would AUX O
+seem VERB O
+a DET O
+plausible ADJ O
+explanation NOUN O
+of ADP O
+the DET O
+inadequacy NOUN O
+of ADP O
+the DET O
+aging VERB O
+immune ADJ O
+system NOUN O
+to PART O
+clear VERB O
+this DET O
+virus NOUN O
+efficiently ADV O
+[ PUNCT O
+16–19 NUM O
+] PUNCT O
+. PUNCT O
+
+Both DET O
+ORs NOUN B-AC
+and CCONJ O
+MDs NOUN B-AC
+are AUX O
+reported VERB O
+with ADP O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+Whereas SCONJ O
+NaR PROPN B-AC
+shares VERB O
+with ADP O
+NR PROPN B-AC
+the DET O
+ability NOUN O
+to PART O
+be AUX O
+utilized VERB O
+by ADP O
+bna1 NOUN O
+npt1 NOUN O
+and CCONJ O
+bna1 NOUN O
+nrk1 NOUN O
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+, PUNCT O
+the DET O
+Qns1 PROPN O
+requirement NOUN O
+for ADP O
+NaR PROPN B-AC
+indicates VERB O
+that SCONJ O
+NaR PROPN B-AC
+metabolites NOUN O
+must AUX O
+flow VERB O
+through ADP O
+nicotinic ADJ B-LF
+acid NOUN I-LF
+mononucleotide NOUN I-LF
+( PUNCT O
+NaMN PROPN B-AC
+) PUNCT O
+and CCONJ O
+nicotinic ADJ B-LF
+acid NOUN I-LF
+adenine NOUN I-LF
+dinucleotide NOUN I-LF
+( PUNCT O
+NaAD PROPN B-AC
+) PUNCT O
+as SCONJ O
+schematized VERB O
+in ADP O
+Figure PROPN O
+7 NUM O
+. PUNCT O
+
+Indicated VERB O
+are AUX O
+the DET O
+cerebral ADJ B-LF
+cortex NOUN I-LF
+( PUNCT O
+CX NOUN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+hippocampus NOUN B-LF
+( PUNCT O
+HP NOUN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+thalamus NOUN B-LF
+( PUNCT O
+TH NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+putamen NOUN B-LF
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+PU NOUN B-AC
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+
+Potential ADJ O
+risk NOUN O
+factors NOUN O
+for ADP O
+neonatal ADJ O
+mortality NOUN O
+were AUX O
+grouped VERB O
+into ADP O
+the DET O
+following ADJ O
+categories NOUN O
+: PUNCT O
+( PUNCT O
+i X O
+) PUNCT O
+Infants NOUN O
+’ PART O
+individual ADJ O
+characteristics NOUN O
+: PUNCT O
+sex NOUN O
+( PUNCT O
+male ADJ O
+and CCONJ O
+female ADJ O
+) PUNCT O
+, PUNCT O
+gestational ADJ O
+age NOUN O
+( PUNCT O
+< PUNCT O
+34 NUM O
+, PUNCT O
+34–36 NUM O
+, PUNCT O
+and CCONJ O
+≥37 NUM O
+weeks NOUN O
+) PUNCT O
+, PUNCT O
+multiple ADJ O
+gestations NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+birth NOUN O
+rank NOUN O
+( PUNCT O
+1st ADJ O
+, PUNCT O
+2nd ADJ O
+to ADP O
+4th ADJ O
+, PUNCT O
+and CCONJ O
+5th ADJ O
+or CCONJ O
+higher ADJ O
+) PUNCT O
+; PUNCT O
+( PUNCT O
+ii X O
+) PUNCT O
+Maternal ADJ O
+characteristics NOUN O
+: PUNCT O
+birth NOUN O
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+( PUNCT O
+≤2 NUM O
+and CCONJ O
+2–4 NUM O
+years NOUN O
+) PUNCT O
+, PUNCT O
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+age NOUN O
+( PUNCT O
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+18 NUM O
+, PUNCT O
+18–24 NUM O
+, PUNCT O
+25–29 NUM O
+, PUNCT O
+30–34 NUM O
+, PUNCT O
+and CCONJ O
+≥35 NUM O
+years NOUN O
+) PUNCT O
+, PUNCT O
+maternal ADJ O
+mid ADJ B-LF
+- PUNCT I-LF
+upper ADJ I-LF
+arm NOUN I-LF
+circumference NOUN I-LF
+( PUNCT O
+MUAC PROPN B-AC
+) PUNCT O
+( PUNCT O
+< PUNCT O
+22 NUM O
+and CCONJ O
+≥22 NUM O
+cm NOUN O
+) PUNCT O
+, PUNCT O
+history NOUN O
+of ADP O
+previous ADJ O
+child NOUN O
+death NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+; PUNCT O
+( PUNCT O
+iii X O
+) PUNCT O
+Antenatal ADJ O
+factors NOUN O
+: PUNCT O
+antenatal ADJ O
+complications NOUN O
+( PUNCT O
+pregnancy NOUN O
+complications NOUN O
+such ADJ O
+as ADP O
+high ADJ O
+grade NOUN O
+fever NOUN O
+, PUNCT O
+excessive ADJ O
+bleeding NOUN O
+, PUNCT O
+convulsion NOUN O
+, PUNCT O
+swelling NOUN O
+of ADP O
+face NOUN O
+or CCONJ O
+feet NOUN O
+, PUNCT O
+foul ADJ O
+smelling VERB O
+discharge NOUN O
+or CCONJ O
+others NOUN O
+) PUNCT O
+, PUNCT O
+number NOUN O
+of ADP O
+antenatal ADJ O
+care NOUN O
+seeking VERB O
+visits NOUN O
+( PUNCT O
+no DET O
+antenatal ADJ O
+visit NOUN O
+, PUNCT O
+1–3 NUM O
+, PUNCT O
+and CCONJ O
+≥4 NUM O
+visits NOUN O
+) PUNCT O
+, PUNCT O
+receiving VERB O
+a DET O
+tetanus NOUN O
+toxoid NOUN O
+injection NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+tobacco NOUN O
+consumption NOUN O
+during ADP O
+pregnancy NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+; PUNCT O
+( PUNCT O
+iv X O
+) PUNCT O
+Intrapartum ADJ O
+factors NOUN O
+: PUNCT O
+delivery NOUN O
+complications NOUN O
+such ADJ O
+as ADP O
+excessive ADJ O
+bleeding NOUN O
+, PUNCT O
+convulsions NOUN O
+, PUNCT O
+retained VERB O
+placenta NOUN O
+, PUNCT O
+abnormal ADJ O
+presentation NOUN O
+, PUNCT O
+prolonged ADJ O
+labor NOUN O
+, PUNCT O
+premature ADJ O
+water NOUN O
+breaking NOUN O
+, PUNCT O
+or CCONJ O
+others NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+, PUNCT O
+place NOUN O
+of ADP O
+delivery NOUN O
+( PUNCT O
+hospital NOUN O
+and CCONJ O
+home NOUN O
+delivery NOUN O
+) PUNCT O
+, PUNCT O
+delivery NOUN O
+assistance NOUN O
+( PUNCT O
+by ADP O
+skilled ADJ O
+birth NOUN O
+attendants NOUN O
+, PUNCT O
+[ PUNCT O
+doctors NOUN O
+and CCONJ O
+nurses NOUN O
+were AUX O
+included VERB O
+as ADP O
+skilled ADJ O
+birth NOUN O
+attendants NOUN O
+] PUNCT O
+; PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+season NOUN O
+of ADP O
+delivery NOUN O
+( PUNCT O
+winter NOUN O
+or CCONJ O
+not PART O
+winter NOUN O
+) PUNCT O
+; PUNCT O
+and CCONJ O
+finally ADV O
+( PUNCT O
+v X O
+) PUNCT O
+Socio ADJ O
+- PUNCT O
+economic ADJ O
+and CCONJ O
+household NOUN O
+factors NOUN O
+: PUNCT O
+maternal ADJ O
+education NOUN O
+( PUNCT O
+no DET O
+formal ADJ O
+education NOUN O
+, PUNCT O
+primary ADJ O
+, PUNCT O
+and CCONJ O
+secondary ADJ O
+or CCONJ O
+above ADV O
+) PUNCT O
+, PUNCT O
+women NOUN O
+work VERB O
+for ADP O
+cash NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+, PUNCT O
+women NOUN O
+’s PART O
+decision NOUN O
+- PUNCT O
+making VERB O
+power NOUN O
+about ADP O
+treatment NOUN O
+of ADP O
+children NOUN O
+( PUNCT O
+yes INTJ O
+and CCONJ O
+no DET O
+) PUNCT O
+, PUNCT O
+paternal ADJ O
+education NOUN O
+( PUNCT O
+no DET O
+formal ADJ O
+education NOUN O
+, PUNCT O
+primary ADJ O
+, PUNCT O
+and CCONJ O
+secondary ADJ O
+or CCONJ O
+above ADV O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+household NOUN O
+economic ADJ O
+status NOUN O
+( PUNCT O
+poorest ADJ O
+, PUNCT O
+poorer ADJ O
+, PUNCT O
+middle ADJ O
+, PUNCT O
+richer ADJ O
+, PUNCT O
+and CCONJ O
+richest ADJ O
+) PUNCT O
+( PUNCT O
+Fig NOUN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+performed VERB O
+external ADJ O
+evaluation NOUN O
+of ADP O
+the DET O
+models NOUN O
+by ADP O
+evaluating VERB O
+performance NOUN O
+on ADP O
+the DET O
+National PROPN B-LF
+Institutes PROPN I-LF
+of ADP I-LF
+Health PROPN I-LF
+( PUNCT O
+NIH PROPN B-AC
+) PUNCT O
+ChestX PROPN O
+- NOUN O
+ray14 NOUN O
+set NOUN O
+( PUNCT O
+available ADJ O
+at ADP O
+https://nihcc.app.box.com/v/ChestXray-NIHCC X O
+) PUNCT O
+, PUNCT O
+a DET O
+publically ADV O
+available ADJ O
+dataset NOUN O
+of ADP O
+over ADP O
+112,000 NUM O
+frontal ADJ O
+chest NOUN O
+radiographs NOUN O
+accompanied VERB O
+by ADP O
+labels NOUN O
+extracted VERB O
+from ADP O
+accompanying VERB O
+radiology NOUN O
+reports NOUN O
+using VERB O
+natural ADJ O
+language NOUN O
+processing NOUN O
+. PUNCT O
+
+Intravenous ADJ O
+fluids NOUN O
+, PUNCT O
+vasopressors NOUN O
+, PUNCT O
+and CCONJ O
+inotropic ADJ O
+support NOUN O
+( PUNCT O
+norepinephrine NOUN O
+and/or CCONJ O
+epinephrine NOUN O
+) PUNCT O
+were AUX O
+administered VERB O
+to PART O
+achieve VERB O
+and CCONJ O
+maintain VERB O
+an DET O
+adequate ADJ O
+cerebral ADJ B-LF
+perfusion NOUN I-LF
+pressure NOUN I-LF
+( PUNCT O
+CPP NOUN B-AC
+> ADP O
+60 NUM O
+mm NOUN O
+Hg NOUN O
+) PUNCT O
+. PUNCT O
+
+Seven NUM O
+of ADP O
+15 NUM O
+clinical ADJ O
+trial NOUN O
+participants NOUN O
+treated VERB O
+with ADP O
+a DET O
+nucleoside NOUN O
+analogue NOUN O
+( PUNCT O
+fialuridine PROPN B-LF
+[ X O
+FIAU PROPN B-AC
+] PUNCT O
+) PUNCT O
+developed VERB O
+acute ADJ O
+liver NOUN O
+failure NOUN O
+. PUNCT O
+
+The DET O
+effect NOUN O
+of ADP O
+temperature NOUN O
+on ADP O
+protease NOUN O
+activity NOUN O
+was AUX O
+analysed VERB O
+by ADP O
+incubating VERB O
+reaction NOUN O
+mixture NOUN O
+containing VERB O
+partially ADV B-LF
+purified VERB I-LF
+extract NOUN I-LF
+( PUNCT O
+PPE PROPN B-AC
+) PUNCT O
+and CCONJ O
+buffered VERB O
+casein NOUN O
+for ADP O
+an PRON O
+at ADP O
+20 NUM O
+° NOUN B-AC
+C NOUN B-AC
+, PUNCT O
+30 NUM O
+° NOUN B-AC
+C,40 NUM O
+° NOUN B-AC
+C NOUN B-AC
+, PUNCT O
+50 NUM O
+° NOUN B-AC
+C NOUN B-AC
+, PUNCT O
+60 NUM O
+° NOUN B-AC
+C NOUN B-AC
+, PUNCT O
+70 NUM O
+° NOUN B-AC
+C NOUN B-AC
+, PUNCT O
+80 NUM O
+° NOUN B-AC
+C NOUN B-AC
+, PUNCT O
+90 NUM O
+° NOUN B-AC
+C NOUN B-AC
+and CCONJ O
+100 NUM O
+° NOUN B-AC
+C NOUN B-AC
+. PUNCT O
+
+The DET O
+WHO PROPN B-AC
+/ SYM O
+UNICEF PROPN B-AC
+’s PART O
+Joint PROPN B-LF
+Monitoring PROPN I-LF
+Programme PROPN I-LF
+( PUNCT O
+JMP PROPN B-AC
+) PUNCT O
+tracked VERB O
+progress NOUN O
+toward ADP O
+MDG PROPN B-AC
+targets NOUN O
+via ADP O
+the DET O
+drinking NOUN O
+water NOUN O
+and CCONJ O
+sanitation NOUN O
+ladders NOUN O
+( PUNCT O
+see VERB O
+Box NOUN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+Ag.pTfh PROPN B-AC
+, PUNCT O
+antigen NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+peripheral ADJ I-LF
+T NOUN I-LF
+follicular ADJ I-LF
+helper NOUN I-LF
+; PUNCT O
+HC PROPN B-AC
+, PUNCT O
+healthy ADJ B-LF
+control NOUN I-LF
+; PUNCT O
+PBMC PROPN B-AC
+, PUNCT O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cell NOUN I-LF
+; PUNCT O
+VNR PROPN B-AC
+, PUNCT O
+vaccine NOUN B-LF
+nonresponder NOUN I-LF
+; PUNCT O
+VR PROPN B-AC
+, PUNCT O
+vaccine NOUN B-LF
+responder NOUN I-LF
+. PUNCT O
+
+bERCD PROPN O
+( PUNCT O
+elective ADJ O
+repeat ADJ O
+cesarean ADJ O
+delivery NOUN O
+) PUNCT O
+, PUNCT O
+VBAC PROPN B-AC
+( PUNCT O
+vaginal ADJ B-LF
+birth NOUN I-LF
+after ADP I-LF
+cesarean ADJ I-LF
+) PUNCT O
+, PUNCT O
+URCD PROPN B-AC
+( PUNCT O
+unplanned ADJ B-LF
+repeat ADJ I-LF
+cesarean ADJ I-LF
+delivery NOUN I-LF
+) PUNCT O
+
+HEK PROPN B-AC
+, PUNCT O
+human ADJ B-LF
+embryonic ADJ I-LF
+kidney NOUN I-LF
+. PUNCT O
+
+We PRON O
+isolated VERB O
+the DET O
+precursor NOUN O
+cell NOUN O
+type NOUN O
+of ADP O
+DSCs NOUN B-AC
+, PUNCT O
+endometrial ADJ B-LF
+stromal ADJ I-LF
+fibroblasts NOUN I-LF
+( PUNCT O
+ESFs PROPN B-AC
+) PUNCT O
+, PUNCT O
+from ADP O
+the DET O
+opossum NOUN O
+Monodelphis PROPN O
+domestica NOUN O
+. PUNCT O
+
+Length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+( PUNCT O
+LoS PROPN B-AC
+) PUNCT O
+, PUNCT O
+resource NOUN B-LF
+utilization NOUN I-LF
+( PUNCT O
+RU PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+predicted VERB O
+diagnostic ADJ O
+accuracy NOUN O
+of ADP O
+the DET O
+1 NUM O
+- PUNCT O
+h NOUN O
+algorithm NOUN O
+compared VERB O
+to ADP O
+standard NOUN B-LF
+of ADP I-LF
+care NOUN I-LF
+( PUNCT O
+SoC PROPN B-AC
+) PUNCT O
+in ADP O
+the DET O
+ED PROPN B-AC
+were AUX O
+estimated VERB O
+. PUNCT O
+
+In ADP O
+contrast NOUN O
+to PART O
+other ADJ O
+studies NOUN O
+which PRON O
+showed VERB O
+that SCONJ O
+bedridden ADJ O
+patients NOUN O
+are AUX O
+associated VERB O
+with ADP O
+lost VERB B-LF
+to PART I-LF
+follow VERB I-LF
+up ADP I-LF
+[ X O
+15,32 NUM O
+] PUNCT O
+, PUNCT O
+in ADP O
+this DET O
+study NOUN O
+being AUX O
+bed NOUN O
+ridden VERB O
+patient NOUN O
+is AUX O
+not PART O
+associated VERB O
+with ADP O
+LTFU PROPN B-AC
+. PUNCT O
+This PRON O
+might AUX O
+be AUX O
+because SCONJ O
+of ADP O
+in ADP O
+this DET O
+study NOUN O
+there PRON O
+were VERB O
+small ADJ O
+number NOUN O
+of ADP O
+bedridden ADJ O
+patients NOUN O
+( PUNCT O
+very ADV O
+small ADJ O
+sample NOUN O
+size NOUN O
+) PUNCT O
+which PRON O
+may AUX O
+result VERB O
+a DET O
+biased VERB O
+statistical ADJ O
+estimation NOUN O
+. PUNCT O
+
+Please INTJ O
+add VERB O
+the DET O
+following ADJ O
+statement NOUN O
+, PUNCT O
+or CCONJ O
+similar ADJ O
+, PUNCT O
+to ADP O
+the DET O
+Methods NOUN O
+: PUNCT O
+" PUNCT O
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+as ADP O
+per ADP O
+the DET O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+guideline NOUN O
+( PUNCT O
+S1 PROPN O
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+" PUNCT O
+
+However ADV O
+, PUNCT O
+the DET O
+incidence NOUN O
+and CCONJ O
+mortality NOUN O
+related VERB O
+to ADP O
+these DET O
+conditions NOUN O
+in ADP O
+patients NOUN O
+infected VERB O
+with ADP O
+hepatitis PROPN B-LF
+C PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+HCV PROPN B-AC
+) PUNCT O
+are AUX O
+unclear ADJ O
+, PUNCT O
+as SCONJ O
+is AUX O
+whether SCONJ O
+antiviral ADJ O
+therapy NOUN O
+could AUX O
+change VERB O
+their PRON O
+infection NOUN O
+risk NOUN O
+. PUNCT O
+
+Plasmodium NOUN B-LF
+falciparum NOUN I-LF
+strain NOUN I-LF
+FCR3 NOUN I-LF
+
+PSG PROPN B-AC
+, PUNCT O
+polysomnography NOUN B-LF
+. PUNCT O
+
+Directly ADV B-LF
+observed VERB I-LF
+treatment NOUN I-LF
+, PUNCT I-LF
+short ADJ I-LF
+- PUNCT I-LF
+course NOUN I-LF
+( PUNCT O
+DOTS PROPN B-AC
+) PUNCT O
+TB PROPN B-AC
+treatment NOUN O
+services NOUN O
+are AUX O
+given VERB O
+in ADP O
+all DET O
+the DET O
+health NOUN O
+facilities NOUN O
+. PUNCT O
+
+The DET O
+endoplasmic NOUN B-LF
+reticulum NOUN I-LF
+( PUNCT O
+ER NOUN B-AC
+) PUNCT O
+is AUX O
+responsible ADJ O
+for ADP O
+production NOUN O
+and CCONJ O
+folding NOUN O
+of ADP O
+secreted VERB O
+proteins NOUN O
+. PUNCT O
+
+The DET O
+resulting VERB O
+equilibrium NOUN B-LF
+dissociation NOUN I-LF
+constants NOUN I-LF
+KD NOUN B-AC
+, PUNCT O
+kinetic ADJ O
+association NOUN O
+kon NOUN O
+and CCONJ O
+dissociation NOUN O
+koff NOUN O
+rates NOUN O
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+given VERB O
+in ADP O
+Table PROPN O
+2 NUM O
+. PUNCT O
+
+For ADP O
+the DET O
+competition NOUN O
+assays NOUN O
+between ADP O
+N2 PROPN O
+and CCONJ O
+JU1648 PROPN O
+, PUNCT O
+we PRON O
+used VERB O
+a DET O
+generalized ADJ B-LF
+linear ADJ I-LF
+model NOUN I-LF
+( PUNCT O
+GLM PROPN B-AC
+) PUNCT O
+to PART O
+assess VERB O
+the DET O
+variation NOUN O
+of ADP O
+nath-10(haw6805 NOUN O
+) PUNCT O
+allele NOUN O
+frequency NOUN O
+over ADP O
+time NOUN O
+and CCONJ O
+across ADP O
+growth NOUN O
+conditions NOUN O
+. PUNCT O
+
+KV PROPN B-AC
+, PUNCT O
+Kupffer PROPN B-LF
+’s PART I-LF
+vesicle NOUN I-LF
+; PUNCT O
+α NOUN B-AC
+- NOUN B-AC
+Tubulin NOUN B-AC
+, PUNCT O
+acetylated VERB B-LF
+tubulin NOUN I-LF
+. PUNCT O
+
+The DET O
+longer ADJ O
+of ADP O
+the DET O
+two NUM O
+most ADV O
+highly ADV O
+conserved ADJ O
+elements NOUN O
+at ADP O
+Or42a PROPN O
+, PUNCT O
+42a4 PROPN O
+, PUNCT O
+contains VERB O
+an DET O
+inverted ADJ O
+repeat NOUN O
+: PUNCT O
+AGTGTAAAAGTTTACACTT NOUN O
+. PUNCT O
+We PRON O
+were AUX O
+surprised ADJ O
+to ADP O
+find VERB O
+that SCONJ O
+mutation NOUN O
+of ADP O
+this DET O
+element NOUN O
+led VERB O
+to ADP O
+a DET O
+2 ADJ O
+- PUNCT O
+fold ADJ O
+increase NOUN O
+in ADP O
+the DET O
+number NOUN O
+of ADP O
+labeled VERB O
+maxillary ADJ O
+palp NOUN O
+cells NOUN O
+, PUNCT O
+from ADP O
+18.2 NUM O
+± SYM O
+1.8 NUM O
+( PUNCT O
+n NOUN O
+= SYM O
+9 NUM O
+maxillary ADJ O
+palps NOUN O
+) PUNCT O
+to ADP O
+33.2 NUM O
+± SYM O
+3.7 NUM O
+( PUNCT O
+n NOUN O
+= SYM O
+9 NUM O
+maxillary ADJ O
+palps NOUN O
+quantified VERB O
+from ADP O
+two NUM O
+independent ADJ O
+lines NOUN O
+; PUNCT O
+n NOUN O
+= SYM O
+8 NUM O
+independent ADJ O
+lines NOUN O
+examined VERB O
+, PUNCT O
+n NOUN O
+> SYM O
+20 NUM O
+maxillary ADJ O
+palps NOUN O
+examined VERB O
+/ SYM O
+line NOUN O
+) PUNCT O
+( PUNCT O
+Figure PROPN O
+3A–3C NUM O
+) PUNCT O
+. PUNCT O
+The DET O
+simplest ADJ O
+interpretation NOUN O
+of ADP O
+this DET O
+result NOUN O
+is AUX O
+that SCONJ O
+42a4 PROPN O
+is AUX O
+a DET O
+negative ADJ O
+regulatory ADJ O
+element NOUN O
+that SCONJ O
+represses VERB O
+Or42a PROPN O
+in ADP O
+a DET O
+subset NOUN O
+of ADP O
+ORNs PROPN B-AC
+. PUNCT O
+To PART O
+test VERB O
+this DET O
+interpretation NOUN O
+, PUNCT O
+we PRON O
+first ADV O
+carried VERB O
+out ADP O
+a DET O
+double ADJ O
+- PUNCT O
+label NOUN O
+experiment NOUN O
+using VERB O
+probes NOUN O
+for ADP O
+the DET O
+endogenous ADJ O
+Or42a PROPN O
+mRNA NOUN O
+and CCONJ O
+for ADP O
+the DET O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+GFP PROPN B-AC
+) PUNCT O
+that SCONJ O
+is AUX O
+driven VERB O
+by ADP O
+the DET O
+mutant ADJ O
+promoter NOUN O
+via ADP O
+GAL4 PROPN O
+. PUNCT O
+We PRON O
+found VERB O
+that SCONJ O
+all DET O
+Or42a+ PROPN O
+cells NOUN O
+express VERB O
+GFP PROPN B-AC
+, PUNCT O
+but CCONJ O
+that SCONJ O
+GFP PROPN B-AC
+is AUX O
+also ADV O
+expressed VERB O
+in ADP O
+an DET O
+additional ADJ O
+subset NOUN O
+of ADP O
+cells NOUN O
+( PUNCT O
+Figure PROPN O
+3D NUM O
+) PUNCT O
+. PUNCT O
+
+A DET O
+GWAS NOUN B-AC
+for ADP O
+CAD PROPN B-AC
+conducted VERB O
+in ADP O
+the DET O
+Chinese ADJ O
+Han PROPN O
+population NOUN O
+had AUX O
+identified VERB O
+a DET O
+variant NOUN O
+, PUNCT O
+rs6903956 NOUN O
+, PUNCT O
+within ADP O
+intron NOUN O
+1 NUM O
+of ADP O
+the DET O
+C6orf105 PROPN O
+gene NOUN O
+( PUNCT O
+also ADV O
+known VERB O
+as ADP O
+the DET O
+androgen NOUN B-LF
+dependent ADJ I-LF
+tissue NOUN I-LF
+factor NOUN I-LF
+pathway NOUN I-LF
+inhibitor NOUN I-LF
+regulating VERB I-LF
+protein NOUN I-LF
+or CCONJ O
+ADTRP PROPN B-AC
+) PUNCT O
+on ADP O
+chromosome NOUN O
+6p24.1 NUM O
+. PUNCT O
+
+RT NOUN B-AC
+: PUNCT O
+radiation NOUN B-LF
+. PUNCT O
+
+Motor NOUN B-LF
+thresholds NOUN I-LF
+( PUNCT O
+MTs NOUN B-AC
+) PUNCT O
+were AUX O
+measured VERB O
+at ADP O
+the DET O
+relaxed ADJ O
+first ADJ B-LF
+dorsal ADJ I-LF
+interosseous ADJ I-LF
+( PUNCT O
+FDI PROPN B-AC
+) PUNCT O
+muscle NOUN O
+of ADP O
+the DET O
+right ADJ O
+hand NOUN O
+using VERB O
+single ADJ O
+- PUNCT O
+pulse NOUN O
+TMS NOUN O
+[ X O
+20,46,71 NUM O
+] PUNCT O
+. PUNCT O
+
+Two NUM O
+proteins NOUN O
+of ADP O
+interest NOUN O
+X NOUN O
+and CCONJ O
+Y NOUN O
+are AUX O
+fused VERB O
+to ADP O
+the DET O
+N NOUN B-LF
+- PUNCT I-LF
+terminal NOUN I-LF
+half NOUN I-LF
+of ADP I-LF
+ubiquitin NOUN I-LF
+and CCONJ O
+to ADP O
+the DET O
+C NOUN B-LF
+- PUNCT I-LF
+terminal NOUN I-LF
+half NOUN I-LF
+of ADP I-LF
+ubiquitin NOUN I-LF
+extended VERB O
+by ADP O
+the DET O
+RUra3 PROPN O
+reporter NOUN O
+, PUNCT O
+Nub PROPN B-AC
+and CCONJ O
+Cub PROPN B-AC
+- PUNCT O
+RUra3 PROPN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+QEESI PROPN B-AC
+, PUNCT O
+Quick PROPN O
+Environmental PROPN O
+Exposure PROPN O
+and CCONJ O
+Sensitivity PROPN O
+Inventory PROPN O
+; PUNCT O
+MCS PROPN B-AC
+, PUNCT O
+multiple ADJ B-LF
+chemical NOUN I-LF
+sensitivity NOUN I-LF
+
+Plasma NOUN O
+HIV PROPN O
+- PUNCT O
+RNA NOUN O
+viral ADJ B-LF
+load NOUN I-LF
+( PUNCT O
+VL PROPN B-AC
+) PUNCT O
+testing NOUN O
+for ADP O
+the DET O
+early ADJ O
+diagnosis NOUN O
+of ADP O
+paediatric ADJ O
+HIV PROPN O
+infection NOUN O
+was AUX O
+performed VERB O
+using VERB O
+a DET O
+quantitative ADJ O
+real ADJ O
+- PUNCT O
+time NOUN O
+RT NOUN O
+- PUNCT O
+PCR NOUN O
+technique NOUN O
+targeted VERB O
+at ADP O
+the DET O
+HIV-1 PROPN O
+LTR PROPN O
+gene NOUN O
+as SCONJ O
+previously ADV O
+validated VERB O
+[ PUNCT O
+25 NUM O
+] PUNCT O
+. PUNCT O
+
+SSAO PROPN B-AC
+, PUNCT O
+semicarbazide NOUN B-LF
+- PUNCT I-LF
+sensitive ADJ I-LF
+amine NOUN I-LF
+oxidase NOUN I-LF
+. PUNCT O
+
+Three NUM O
+hundred NUM O
+and CCONJ O
+fifteen NUM O
+Diversity PROPN O
+Array PROPN O
+Technology PROPN O
+( PUNCT O
+DArT PROPN O
+) PUNCT O
+markers NOUN O
+and CCONJ O
+84 NUM O
+Simple PROPN O
+Sequence PROPN O
+Repeat PROPN O
+( PUNCT O
+SSR PROPN O
+) PUNCT O
+markers NOUN O
+and CCONJ O
+phenotypic ADJ O
+data NOUN O
+were AUX O
+subjected VERB O
+to PART O
+MapQTL5.0 PROPN O
+[ X O
+18 NUM O
+] X O
+to PART O
+identify VERB O
+Quantitative PROPN B-LF
+Traits PROPN I-LF
+Loci/ PROPN I-LF
+locus NOUN I-LF
+( PUNCT O
+QTL PROPN B-AC
+) PUNCT O
+linked VERB O
+with ADP O
+plant NOUN O
+height NOUN O
+at ADP O
+maturity NOUN O
+, PUNCT O
+germination NOUN O
+percentage NOUN O
+in ADP O
+salinity NOUN O
+stress NOUN O
+, PUNCT O
+biomass NOUN O
+yield NOUN O
+at ADP O
+seedling NOUN O
+emergence NOUN O
+and CCONJ O
+first ADJ O
+leaf NOUN O
+full ADJ O
+expansion NOUN O
+growth NOUN O
+stages NOUN O
+. PUNCT O
+
+During ADP O
+five NUM O
+years NOUN O
+, PUNCT O
+adverse ADJ O
+events NOUN O
+, PUNCT O
+survival NOUN O
+rates NOUN O
+for ADP O
+grafts NOUN O
+and CCONJ O
+patients NOUN O
+, PUNCT O
+and CCONJ O
+incidence NOUN O
+of ADP O
+biopsy NOUN B-LF
+- PUNCT I-LF
+proven VERB I-LF
+acute ADJ I-LF
+rejection NOUN I-LF
+( PUNCT O
+BPAR PROPN B-AC
+) PUNCT O
+and CCONJ O
+dnDSA NOUN B-AC
+production NOUN O
+for ADP O
+the DET O
+two NUM O
+groups NOUN O
+were AUX O
+monitored VERB O
+and CCONJ O
+compared VERB O
+. PUNCT O
+
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+KO PROPN B-AC
+- PUNCT O
+B PROPN O
+, PUNCT O
+knockout NOUN B-LF
+, PUNCT O
+C57BL/6 PROPN O
+; PUNCT O
+KO PROPN B-AC
+- PUNCT O
+H PROPN O
+, PUNCT O
+knockout NOUN B-LF
+, PUNCT O
+hybrid NOUN O
+; PUNCT O
+L NOUN O
+, PUNCT O
+left ADJ O
+; PUNCT O
+ns NOUN O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+O NOUN O
+, PUNCT O
+opposite ADJ O
+; PUNCT O
+R NOUN O
+, PUNCT O
+right ADJ O
+; PUNCT O
+T NOUN O
+, PUNCT O
+target NOUN O
+quadrant NOUN O
+; PUNCT O
+WT NOUN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Extracellular ADJ O
+application NOUN O
+of ADP O
+a DET O
+selective ADJ O
+Group PROPN O
+I NUM O
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+agonist NOUN O
+( PUNCT O
+S)-3,5 NOUN O
+- PUNCT O
+Dihydroxyphenylglycine NOUN O
+( PUNCT O
+DHPG PROPN B-AC
+) PUNCT O
+( PUNCT O
+10 NUM O
+μM NOUN O
+) PUNCT O
+for ADP O
+3 NUM O
+min NOUN O
+induced VERB O
+a DET O
+rapid ADJ O
+reduction NOUN O
+of ADP O
+GlyR NOUN B-AC
+- PUNCT O
+IPSCs NOUN B-AC
+( PUNCT O
+Fig NOUN O
+1A NUM O
+) PUNCT O
+. PUNCT O
+This DET O
+synaptic ADJ O
+depression NOUN O
+was AUX O
+specific ADJ O
+to ADP O
+glycinergic ADJ O
+responses NOUN O
+because SCONJ O
+the DET O
+same ADJ O
+DHPG PROPN B-AC
+treatment NOUN O
+generated VERB O
+no DET O
+changes NOUN O
+in ADP O
+the DET O
+amplitudes NOUN O
+of ADP O
+γ NOUN O
+- PUNCT O
+Aminobutyric ADJ O
+acid NOUN O
+type NOUN O
+A PROPN O
+( PUNCT O
+GABAA)-receptor NOUN O
+– PUNCT O
+mediated VERB O
+IPSCs NOUN B-AC
+( PUNCT O
+Fig NOUN O
+1B NUM O
+) PUNCT O
+. PUNCT O
+Group PROPN O
+I NUM O
+mGluRs NOUN O
+consist VERB O
+of ADP O
+two NUM O
+subtypes NOUN O
+: PUNCT O
+mGluR1 NOUN O
+and CCONJ O
+mGluR5 NOUN B-AC
+. PUNCT O
+To PART O
+determine VERB O
+which DET O
+subtype NOUN O
+was AUX O
+responsible ADJ O
+for ADP O
+DHPG PROPN B-AC
+action NOUN O
+, PUNCT O
+we PRON O
+pretreated VERB O
+the DET O
+slices NOUN O
+with ADP O
+selective ADJ O
+mGluR1 NOUN O
+antagonist NOUN O
+CPCCOEt PROPN O
+or CCONJ O
+mGluR5 NOUN B-AC
+antagonist NOUN O
+6 NUM B-LF
+- PUNCT I-LF
+Methyl-2-(phenylethynyl NOUN I-LF
+) PUNCT I-LF
+pyridine NOUN I-LF
+( PUNCT O
+MPEP PROPN B-AC
+) PUNCT O
+before ADP O
+DHPG PROPN B-AC
+application NOUN O
+. PUNCT O
+
+The DET O
+pr NOUN B-AC
+locus NOUN O
+encodes VERB O
+an DET O
+enzyme NOUN O
+, PUNCT O
+which PRON O
+, PUNCT O
+along ADP O
+with ADP O
+Punch PROPN B-LF
+( PUNCT O
+Pu PROPN B-AC
+) PUNCT O
+and CCONJ O
+Sepiapterin NOUN B-LF
+reductase NOUN I-LF
+( PUNCT O
+Sptr PROPN B-AC
+) PUNCT O
+, PUNCT O
+functions VERB O
+in ADP O
+the DET O
+synthesis NOUN O
+of ADP O
+the DET O
+enzymatic ADJ O
+cofactor NOUN O
+tetrahydrobiopterin NOUN B-LF
+( PUNCT O
+BH4 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Primary ADJ B-LF
+sclerosing ADJ I-LF
+cholangitis NOUN I-LF
+( PUNCT O
+PSC PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+chronic ADJ O
+inflammatory ADJ O
+disease NOUN O
+of ADP O
+intra- ADJ O
+and CCONJ O
+extrahepatic ADJ O
+bile NOUN O
+ducts NOUN O
+with ADP O
+characteristic ADJ O
+strictures NOUN O
+and CCONJ O
+bile NOUN O
+duct NOUN O
+obstruction NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+NADPH NOUN B-AC
+oxidases NOUN O
+are AUX O
+plasma NOUN B-LF
+membrane NOUN I-LF
+( PUNCT O
+PM)-bound NOUN B-AC
+enzymes NOUN O
+with ADP O
+six NUM O
+trans NOUN O
+- NOUN O
+membrane NOUN O
+domains NOUN O
+, PUNCT O
+an DET O
+N NOUN O
+- NOUN O
+terminal NOUN O
+region NOUN O
+that PRON O
+contains VERB O
+EF NOUN O
+- NOUN O
+hands NOUN O
+, PUNCT O
+and CCONJ O
+a DET O
+C NOUN O
+- NOUN O
+terminal NOUN O
+oxidase NOUN O
+domain NOUN O
+responsible ADJ O
+for ADP O
+oxidizing VERB O
+O2 NOUN O
+to PART O
+produce VERB O
+superoxide NOUN O
+radicals NOUN O
+in ADP O
+the DET O
+apoplast NOUN O
+( PUNCT O
+reviewed VERB O
+in ADP O
+[ X O
+13],[14 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+FEF25 NUM O
+- SYM O
+75 NUM O
+% NOUN O
+: PUNCT O
+forced VERB O
+expiratory ADJ O
+flow NOUN O
+at ADP O
+25–75 NUM O
+% NOUN O
+of ADP O
+FVC PROPN B-AC
+. PUNCT O
+FEV1 PROPN B-AC
+: PUNCT O
+1st ADJ B-LF
+s NOUN I-LF
+forced VERB I-LF
+expiratory ADJ I-LF
+volume NOUN I-LF
+. PUNCT O
+
+AACE PROPN O
+: PUNCT O
+American PROPN O
+College PROPN O
+of ADP O
+Endocrinology PROPN O
+; PUNCT O
+AHA PROPN B-AC
+/ SYM B-AC
+NHLBI PROPN B-AC
+: PUNCT O
+American PROPN B-LF
+Heart PROPN I-LF
+Association PROPN I-LF
+and CCONJ I-LF
+National PROPN I-LF
+Heart PROPN I-LF
+Lung PROPN I-LF
+and CCONJ I-LF
+Blood PROPN I-LF
+Institute PROPN I-LF
+; PUNCT O
+IDF PROPN B-AC
+: PUNCT O
+International PROPN B-LF
+Diabetes PROPN I-LF
+Federation PROPN I-LF
+; PUNCT O
+JIS PROPN B-AC
+: PUNCT O
+Joint PROPN B-LF
+Interim PROPN I-LF
+Statement PROPN I-LF
+; PUNCT O
+NCEP PROPN O
+- PUNCT O
+ATPIII PROPN O
+: PUNCT O
+National PROPN O
+Cholesterol PROPN O
+Education PROPN O
+Program PROPN O
+Adult PROPN O
+Treatment PROPN O
+Panel PROPN O
+III NUM O
+; PUNCT O
+WHO PROPN B-AC
+: PUNCT O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+; PUNCT O
+DM NOUN B-AC
+: PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+; PUNCT O
+T2DM NOUN B-AC
+: PUNCT O
+Type NOUN B-LF
+2 NUM I-LF
+Diabetes PROPN I-LF
+mellitus NOUN I-LF
+; PUNCT O
+HDL NOUN B-AC
+- PUNCT O
+c NOUN O
+: PUNCT O
+high ADJ B-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+; PUNCT O
+BMI NOUN B-AC
+: PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+BP NOUN B-AC
+: PUNCT O
+bloodpPressure NOUN O
+; PUNCT O
+WC NOUN B-AC
+: PUNCT O
+waist NOUN B-LF
+circumference NOUN I-LF
+; PUNCT O
+FG NOUN B-AC
+: PUNCT O
+fasting VERB B-LF
+glucose NOUN I-LF
+; PUNCT O
+HBP NOUN B-AC
+: PUNCT O
+high ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+. PUNCT O
+
+Receiver NOUN B-LF
+operating NOUN I-LF
+characteristic NOUN I-LF
+( PUNCT O
+ROC PROPN B-AC
+) PUNCT O
+curve NOUN O
+was AUX O
+plotted VERB O
+by ADP O
+“ PUNCT O
+pROC NOUN O
+” PUNCT O
+package NOUN O
+of ADP O
+R PROPN O
+[ X O
+26 NUM O
+] PUNCT O
+. PUNCT O
+
+Celiac PROPN B-LF
+disease NOUN I-LF
+( PUNCT O
+CD NOUN B-AC
+) PUNCT O
+is AUX O
+a DET O
+chronic ADJ O
+immune ADJ O
+- PUNCT O
+mediated VERB O
+disorder NOUN O
+triggered VERB O
+by ADP O
+the DET O
+ingestion NOUN O
+of ADP O
+gluten NOUN O
+in ADP O
+genetically ADV O
+susceptible ADJ O
+individuals NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+DC PROPN B-AC
+, PUNCT O
+dendritic ADJ B-LF
+cell NOUN I-LF
+. PUNCT O
+
+FCS PROPN B-AC
+, PUNCT O
+fluorescence NOUN B-LF
+correlation NOUN I-LF
+spectroscopy NOUN I-LF
+. PUNCT O
+
+Examples NOUN O
+are AUX O
+the DET O
+Ecopath PROPN B-LF
+With ADP I-LF
+Ecosim PROPN I-LF
+( PUNCT O
+EwE PROPN B-AC
+) PUNCT O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+and CCONJ O
+Atlantis PROPN O
+[ PUNCT O
+15 NUM O
+] PUNCT O
+models NOUN O
+. PUNCT O
+
+To PART O
+examine VERB O
+the DET O
+relationship NOUN O
+between ADP O
+optical ADJ B-LF
+coherence NOUN I-LF
+tomography NOUN I-LF
+( PUNCT O
+OCT PROPN B-AC
+) PUNCT O
+images NOUN O
+and CCONJ O
+clinical ADJ O
+course NOUN O
+in ADP O
+eyes NOUN O
+with ADP O
+branch NOUN B-LF
+retinal ADJ I-LF
+vein NOUN I-LF
+occlusion NOUN I-LF
+( PUNCT O
+BRVO PROPN B-AC
+) PUNCT O
+treated VERB O
+with ADP O
+intravitreal ADJ B-LF
+ranibizumab NOUN I-LF
+injection NOUN O
+( PUNCT O
+IVR PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+CHI PROPN B-AC
+, PUNCT O
+community NOUN O
+health NOUN O
+index NOUN O
+; PUNCT O
+ISD PROPN B-AC
+, PUNCT O
+Information PROPN B-LF
+Services PROPN I-LF
+Division PROPN I-LF
+; PUNCT O
+NRS PROPN B-AC
+, PUNCT O
+National PROPN B-LF
+Records PROPN I-LF
+of ADP I-LF
+Scotland PROPN I-LF
+; PUNCT O
+SMR02 PROPN B-AC
+, PUNCT O
+Scottish PROPN B-LF
+Morbidity PROPN I-LF
+Record PROPN I-LF
+Maternity PROPN I-LF
+Inpatient PROPN I-LF
+and CCONJ I-LF
+Day PROPN I-LF
+Case PROPN I-LF
+dataset NOUN I-LF
+; PUNCT O
+VBAC PROPN B-AC
+, PUNCT O
+vaginal ADJ B-LF
+birth NOUN I-LF
+after ADP I-LF
+previous ADJ I-LF
+cesarean NOUN I-LF
+. PUNCT O
+
+Dbx1 NOUN B-AC
+, PUNCT O
+developing VERB B-LF
+brain NOUN I-LF
+homeobox NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+preBötC NOUN B-AC
+, PUNCT O
+pre ADJ B-LF
+- ADJ I-LF
+Bötzinger ADJ I-LF
+complex NOUN I-LF
+; PUNCT O
+Trp PROPN B-AC
+, PUNCT O
+transient ADJ B-LF
+receptor NOUN I-LF
+potential NOUN I-LF
+. PUNCT O
+
+Aussie PROPN B-AC
+- PUNCT B-AC
+FIT PROPN B-AC
+builds VERB O
+on ADP O
+the DET O
+FFIT PROPN B-AC
+program NOUN O
+, PUNCT O
+the DET O
+development NOUN O
+and CCONJ O
+evaluation NOUN O
+of ADP O
+which PRON O
+was AUX O
+undertaken VERB O
+by ADP O
+a DET O
+research NOUN O
+team NOUN O
+led VERB O
+by ADP O
+the DET O
+University PROPN O
+of ADP O
+Glasgow PROPN O
+with ADP O
+funding NOUN O
+from ADP O
+various ADJ O
+grants NOUN O
+including VERB O
+a DET O
+Medical PROPN B-LF
+Research PROPN I-LF
+Council PROPN I-LF
+( PUNCT O
+MRC PROPN B-AC
+) PUNCT O
+grant NOUN O
+( PUNCT O
+reference NOUN O
+number NOUN O
+MC_UU_12017/3 NUM O
+) PUNCT O
+, PUNCT O
+a DET O
+Chief PROPN B-LF
+Scientist PROPN I-LF
+Office PROPN I-LF
+( PUNCT O
+CSO PROPN B-AC
+) PUNCT O
+grant NOUN O
+( PUNCT O
+reference NOUN O
+number NOUN O
+CZG/2/504 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+a DET O
+National PROPN B-LF
+Institute PROPN I-LF
+for ADP I-LF
+Health PROPN I-LF
+Research PROPN I-LF
+grant NOUN O
+( PUNCT O
+NIHR PROPN B-AC
+) PUNCT O
+( PUNCT O
+reference NOUN O
+number NOUN O
+09/3010/06 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+volume NOUN B-LF
+variations NOUN I-LF
+of ADP I-LF
+the DET I-LF
+chest NOUN I-LF
+wall NOUN I-LF
+( PUNCT O
+ΔVCW NOUN B-AC
+) PUNCT O
+and CCONJ O
+its PRON O
+compartments NOUN O
+, PUNCT O
+namely ADV O
+pulmonary ADJ O
+ribcage NOUN O
+( PUNCT O
+ΔVRC NOUN B-AC
+, PUNCT B-AC
+P NOUN B-AC
+) PUNCT O
+, PUNCT O
+abdominal ADJ O
+ribcage NOUN O
+( PUNCT O
+ΔVRC NOUN B-AC
+, PUNCT B-AC
+A NOUN B-AC
+) PUNCT O
+and CCONJ O
+abdomen NOUN O
+( PUNCT O
+ΔVAB NOUN B-AC
+) PUNCT O
+were AUX O
+measured VERB O
+by ADP O
+opto ADJ B-LF
+- PUNCT I-LF
+electronic ADJ I-LF
+plethysmography NOUN I-LF
+( PUNCT O
+OEP PROPN B-AC
+, PUNCT O
+BTS PROPN O
+, PUNCT O
+Milan PROPN O
+, PUNCT O
+Italy)[47,48 NUM O
+] PUNCT O
+during ADP O
+at ADV O
+least ADV O
+5 NUM O
+minutes NOUN O
+of ADP O
+spontaneous ADJ O
+QB NOUN B-AC
+before ADV O
+in ADP O
+seated ADJ O
+and CCONJ O
+then ADV O
+other ADJ O
+5 NUM O
+minutes NOUN O
+in ADP O
+supine ADJ O
+position NOUN O
+with ADP O
+the DET O
+child NOUN O
+awake ADJ O
+( PUNCT O
+Brazelton PROPN O
+stage NOUN O
+4)[49 NUM O
+] PUNCT O
+while SCONJ O
+watching VERB O
+a DET O
+cartoon NOUN O
+( PUNCT O
+Fig PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+. PUNCT O
+
+Many ADJ O
+regulatory ADJ O
+neuropeptides NOUN O
+and CCONJ O
+neuropeptide NOUN O
+receptors NOUN O
+and CCONJ O
+other ADJ O
+crucial ADJ O
+genes NOUN O
+pertaining VERB O
+to ADP O
+molting NOUN O
+have AUX O
+been AUX O
+identified VERB O
+, PUNCT O
+including VERB O
+molt NOUN O
+- PUNCT O
+inhibiting VERB O
+hormone NOUN O
+( PUNCT O
+MIH PROPN O
+) PUNCT O
+, PUNCT O
+crustacean ADJ O
+hyperglycemic ADJ O
+hormone NOUN O
+( PUNCT O
+CHH PROPN B-AC
+) PUNCT O
+, PUNCT O
+retinoid NOUN O
+X NOUN O
+receptor NOUN O
+and CCONJ O
+ecdysteroid NOUN B-LF
+receptor NOUN I-LF
+( PUNCT O
+EcR PROPN B-AC
+) PUNCT O
+[ PUNCT O
+4–8 NUM O
+] PUNCT O
+, PUNCT O
+cuticle NOUN O
+- PUNCT O
+related VERB O
+enzymes NOUN O
+( PUNCT O
+chitinases NOUN O
+, PUNCT O
+chitin NOUN O
+deacetylase NOUN O
+, PUNCT O
+and CCONJ O
+chitin NOUN O
+synthase NOUN O
+) PUNCT O
+[ PUNCT O
+9–11 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+structural ADJ O
+proteins NOUN O
+of ADP O
+the DET O
+cuticle NOUN O
+[ PUNCT O
+12 NUM O
+, PUNCT O
+13 NUM O
+] PUNCT O
+. PUNCT O
+
+Right INTJ O
+, PUNCT O
+average ADJ O
+time NOUN O
+- PUNCT O
+point NOUN O
+variability NOUN O
+for ADP O
+the DET O
+different ADJ O
+temporal ADJ O
+jitter NOUN O
+levels NOUN O
+. PUNCT O
+( PUNCT O
+E NOUN O
+- PUNCT O
+H NOUN O
+) PUNCT O
+Same ADJ O
+as ADP O
+( PUNCT O
+A NOUN O
+– SYM O
+D NOUN O
+) PUNCT O
+, PUNCT O
+for ADP O
+second ADJ O
+simulation NOUN O
+, PUNCT O
+using VERB O
+a DET O
+different ADJ O
+IRF PROPN B-AC
+. PUNCT O
+arb NOUN O
+. PUNCT O
+, PUNCT O
+arbitrary ADJ O
+; PUNCT O
+IRF PROPN B-AC
+, PUNCT O
+impulse NOUN B-LF
+response NOUN I-LF
+function NOUN I-LF
+; PUNCT O
+std NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+IB5 PROPN B-AC
+, PUNCT O
+intrabody NOUN B-LF
+5 NUM I-LF
+; PUNCT O
+MEF PROPN B-AC
+, PUNCT O
+Mouse PROPN B-LF
+Embryonic PROPN I-LF
+Fibroblast PROPN I-LF
+; PUNCT O
+PKM2 PROPN O
+, PUNCT O
+pyruvate NOUN O
+kinase NOUN O
+isoform NOUN O
+M2 PROPN O
+; PUNCT O
+scFv PROPN B-AC
+, PUNCT O
+single ADJ B-LF
+- PUNCT I-LF
+chain NOUN I-LF
+variable NOUN I-LF
+fragment NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+
+The DET O
+novel ADJ O
+findings NOUN O
+in ADP O
+the DET O
+study NOUN O
+was AUX O
+the DET O
+identification NOUN O
+of ADP O
+13 NUM O
+additional ADJ O
+proteins NOUN O
+with ADP O
+an DET O
+independent ADJ O
+association NOUN O
+to ADP O
+CV PROPN B-AC
+mortality NOUN O
+in ADP O
+patients NOUN O
+with ADP O
+chronic ADJ O
+CHD PROPN B-AC
+, PUNCT O
+i.e. X O
+, PUNCT O
+TIM-1 PROPN B-AC
+, PUNCT O
+REN PROPN O
+, PUNCT O
+OPG PROPN B-AC
+, PUNCT O
+sST2 PROPN B-AC
+, PUNCT O
+TRAIL PROPN B-AC
+- PUNCT B-AC
+R2 PROPN B-AC
+, PUNCT O
+CA-125 PROPN B-AC
+, PUNCT O
+BNP PROPN B-AC
+, PUNCT O
+HGF PROPN B-AC
+, PUNCT O
+SPON-1 PROPN O
+, PUNCT O
+FGF-23 PROPN B-AC
+, PUNCT O
+CHI3L1 PROPN B-AC
+, PUNCT O
+TNF PROPN B-AC
+- PUNCT B-AC
+R1 PROPN B-AC
+, PUNCT O
+and CCONJ O
+AM PROPN B-AC
+. PUNCT O
+The DET O
+results NOUN O
+indicate VERB O
+that SCONJ O
+myocardial ADJ O
+strain NOUN O
+– PUNCT O
+dysfunction NOUN O
+– PUNCT O
+hypertrophy NOUN O
+– PUNCT O
+fibrosis NOUN O
+( PUNCT O
+NTproBNP PROPN B-AC
+, PUNCT O
+BNP PROPN B-AC
+, PUNCT O
+sST-2 PROPN O
+, PUNCT O
+SPON-1 PROPN O
+, PUNCT O
+and CCONJ O
+CA-125 PROPN B-AC
+) PUNCT O
+, PUNCT O
+myocyte NOUN O
+death NOUN O
+and CCONJ O
+apoptosis NOUN O
+( PUNCT O
+cTnT PROPN B-AC
+- PUNCT B-AC
+hs PROPN B-AC
+, PUNCT O
+TNF PROPN B-AC
+- PUNCT B-AC
+R1 PROPN B-AC
+, PUNCT O
+and CCONJ O
+TRAIL PROPN B-AC
+- PUNCT B-AC
+R2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+kidney NOUN O
+injury NOUN O
+( PUNCT O
+Cys PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+FGF-23 PROPN B-AC
+, PUNCT O
+and CCONJ O
+TIM-1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+hemodynamic ADJ O
+stress NOUN O
+, PUNCT O
+renin NOUN B-LF
+– PUNCT I-LF
+angiotensin NOUN I-LF
+system NOUN I-LF
+( PUNCT O
+RAS PROPN B-AC
+) PUNCT O
+activation NOUN O
+( PUNCT O
+REN PROPN O
+and CCONJ O
+AM PROPN B-AC
+) PUNCT O
+, PUNCT O
+oxidative ADJ O
+stress NOUN O
+and CCONJ O
+inflammation NOUN O
+( PUNCT O
+GDF-15 PROPN B-AC
+, PUNCT O
+IL-6 PROPN B-AC
+, PUNCT O
+OPG PROPN B-AC
+, PUNCT O
+and CCONJ O
+CHI3L1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+angiogenesis NOUN O
+and CCONJ O
+vascular ADJ O
+cell NOUN O
+proliferation NOUN O
+( PUNCT O
+HGF PROPN B-AC
+) PUNCT O
+are AUX O
+important ADJ O
+mechanisms NOUN O
+associated VERB O
+with ADP O
+CV PROPN B-AC
+death NOUN O
+in ADP O
+patients NOUN O
+with ADP O
+chronic ADJ O
+CHD PROPN B-AC
+( PUNCT O
+Fig PROPN O
+5 NUM O
+) PUNCT O
+. PUNCT O
+
+HIV PROPN O
+infection NOUN O
+, PUNCT O
+in ADP O
+particular ADJ O
+, PUNCT O
+is AUX O
+known VERB O
+to ADP O
+be AUX O
+associated VERB O
+with ADP O
+higher ADJ O
+risk NOUN O
+of ADP O
+TB PROPN B-AC
+and CCONJ O
+increases VERB O
+the DET O
+lifetime NOUN O
+risk NOUN O
+of ADP O
+progression NOUN O
+from ADP O
+Mycobacterium NOUN O
+tuberculosis NOUN B-LF
+infection NOUN O
+to ADP O
+active ADJ O
+disease NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+National PROPN B-LF
+Inpatient PROPN I-LF
+Sample PROPN I-LF
+( PUNCT O
+NIS PROPN B-AC
+) PUNCT O
+data NOUN O
+from ADP O
+1998–2016 NUM O
+. PUNCT O
+
+STEMI PROPN O
+, PUNCT O
+ST NOUN O
+- PUNCT O
+segment NOUN O
+elevation NOUN O
+myocardial ADJ O
+infarction NOUN O
+; PUNCT O
+CABG PROPN O
+, PUNCT O
+coronary ADJ O
+artery NOUN O
+bypass NOUN O
+graft NOUN O
+; PUNCT O
+IRA PROPN B-AC
+, PUNCT O
+infarct NOUN B-LF
+- PUNCT I-LF
+related VERB I-LF
+artery NOUN I-LF
+; PUNCT O
+PCI PROPN B-AC
+, PUNCT O
+percutaneous ADJ B-LF
+coronary ADJ I-LF
+intervention NOUN I-LF
+; PUNCT O
+LVEF PROPN B-AC
+, PUNCT O
+left VERB B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+; PUNCT O
+CAG PROPN O
+, PUNCT O
+coronary ADJ O
+angiography NOUN O
+; PUNCT O
+POBA PROPN O
+, PUNCT O
+plain ADJ O
+old ADJ O
+balloon NOUN O
+angioplasty NOUN O
+. PUNCT O
+
+The DET O
+purpose NOUN O
+of ADP O
+this DET O
+review NOUN O
+was AUX O
+to PART O
+summarize VERB O
+the DET O
+published VERB O
+literature NOUN O
+on ADP O
+the DET O
+association NOUN O
+of ADP O
+childhood NOUN O
+, PUNCT O
+adulthood NOUN O
+and CCONJ O
+life NOUN O
+course NOUN O
+socio ADJ B-LF
+- ADJ I-LF
+economic ADJ I-LF
+status NOUN I-LF
+( PUNCT O
+SES PROPN B-AC
+) PUNCT O
+with ADP O
+obesity NOUN O
+between ADP O
+January PROPN O
+1990 NUM O
+and CCONJ O
+June PROPN O
+2015 NUM O
+. PUNCT O
+
+The DET O
+Alzheimer PROPN B-LF
+'s PART I-LF
+Disease PROPN I-LF
+Anti PROPN I-LF
+- PROPN I-LF
+inflammatory ADJ I-LF
+Prevention PROPN I-LF
+Trial PROPN I-LF
+( PUNCT O
+ADAPT PROPN B-AC
+) PUNCT O
+was AUX O
+designed VERB O
+to PART O
+evaluate VERB O
+the DET O
+conventional ADJ O
+NSAID PROPN B-AC
+naproxen NOUN O
+sodium NOUN O
+and CCONJ O
+the DET O
+selective ADJ O
+COX-2 NOUN B-AC
+inhibitor NOUN O
+celecoxib NOUN O
+for ADP O
+primary ADJ O
+prevention NOUN O
+of ADP O
+Alzheimer PROPN B-LF
+'s PART I-LF
+dementia NOUN I-LF
+( PUNCT O
+AD NOUN B-AC
+) PUNCT O
+. PUNCT O
+On ADP O
+17 NUM O
+December PROPN O
+2004 NUM O
+, PUNCT O
+after SCONJ O
+the DET O
+Adenoma PROPN O
+Prevention PROPN O
+with ADP O
+Celecoxib PROPN O
+( PUNCT O
+APC PROPN B-AC
+) PUNCT O
+trial NOUN O
+reported VERB O
+increased VERB O
+cardiovascular ADJ O
+risks NOUN O
+with ADP O
+celecoxib NOUN O
+, PUNCT O
+the DET O
+ADAPT PROPN B-AC
+Steering PROPN O
+Committee PROPN O
+suspended VERB O
+treatment NOUN O
+and CCONJ O
+enrollment NOUN O
+. PUNCT O
+
+The DET O
+updated VERB O
+Position PROPN O
+Statement PROPN O
+[ X O
+3 NUM O
+] X O
+by ADP O
+the DET O
+American PROPN B-LF
+Diabetes PROPN I-LF
+Association PROPN I-LF
+( PUNCT O
+ADA PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+European PROPN B-LF
+Association PROPN I-LF
+for ADP I-LF
+the DET I-LF
+Study PROPN I-LF
+of ADP I-LF
+Diabetes PROPN I-LF
+( PUNCT O
+EASD PROPN B-AC
+) PUNCT O
+endorsed VERB O
+the DET O
+addition NOUN O
+of ADP O
+one NUM O
+of ADP O
+the DET O
+following ADJ O
+glucose NOUN O
+- PUNCT O
+lowering VERB O
+medications NOUN O
+as ADP O
+a DET O
+third ADJ O
+- PUNCT O
+line NOUN O
+option NOUN O
+when SCONJ O
+optimal ADJ O
+glycemic ADJ O
+control NOUN O
+is AUX O
+not PART O
+achieved VERB O
+after ADP O
+3 NUM O
+months NOUN O
+of ADP O
+dual ADJ O
+therapy NOUN O
+: PUNCT O
+thiazolidinedione NOUN B-LF
+( PUNCT O
+TZD PROPN B-AC
+) PUNCT O
+, PUNCT O
+dipeptidyl NOUN O
+peptidase‐4 NOUN O
+inhibitors NOUN O
+( PUNCT O
+DPP4i PROPN B-AC
+) PUNCT O
+, PUNCT O
+sodium‐glucose NOUN B-LF
+co‐transporter‐2 NOUN I-LF
+( PUNCT O
+SGLT2 PROPN B-AC
+) PUNCT O
+inhibitors NOUN O
+, PUNCT O
+glucagon‐like NOUN B-LF
+peptide‐1 NOUN I-LF
+receptor NOUN I-LF
+agonists NOUN I-LF
+( PUNCT O
+GLP1 PROPN B-AC
+- PUNCT B-AC
+RAs PROPN O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+basal ADJ O
+insulin NOUN O
+regimen NOUN O
+. PUNCT O
+
+This DET O
+result NOUN O
+suggests VERB O
+that SCONJ O
+trace NOUN B-LF
+quantities NOUN I-LF
+of ADP I-LF
+organic ADJ I-LF
+matter NOUN I-LF
+( PUNCT O
+TQOM PROPN B-AC
+; PUNCT O
+phthalates NOUN O
+, PUNCT O
+SPNES PROPN B-AC
+, PUNCT O
+amine NOUN O
+compounds NOUN O
+, PUNCT O
+and CCONJ O
+hydrocarbon NOUN O
+) PUNCT O
+in ADP O
+the DET O
+air NOUN O
+are AUX O
+absorbed VERB O
+in ADP O
+concrete ADJ O
+structures NOUN O
+by ADP O
+the DET O
+concrete ADJ O
+respiratory ADJ O
+action NOUN O
+. PUNCT O
+
+Among ADP O
+PWID PROPN O
+in ADP O
+New PROPN B-LF
+South PROPN I-LF
+Wales PROPN I-LF
+( PUNCT O
+NSW PROPN B-AC
+) PUNCT O
+prisons NOUN O
+, PUNCT O
+Australia PROPN O
+, PUNCT O
+the DET O
+length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+( PUNCT O
+LOS NOUN B-AC
+) PUNCT O
+before ADP O
+being AUX O
+released VERB O
+, PUNCT O
+is AUX O
+typically ADV O
+short ADJ O
+( PUNCT O
+average ADJ O
+7–9 NUM O
+months NOUN O
+) PUNCT O
+. PUNCT O
+
+One NUM O
+main ADJ O
+source NOUN O
+of ADP O
+airborne ADJ O
+particulate NOUN B-LF
+matter NOUN I-LF
+( PUNCT O
+PM NOUN B-AC
+) PUNCT O
+in ADP O
+urban ADJ O
+regions NOUN O
+are AUX O
+motor NOUN O
+vehicle NOUN O
+emissions NOUN O
+, PUNCT O
+which PRON O
+can AUX O
+also ADV O
+contain VERB O
+various ADJ O
+metals NOUN O
+and CCONJ O
+toxic ADJ O
+compounds NOUN O
+such ADJ O
+as ADP O
+mutagenic ADJ O
+polyaromatic ADJ O
+hydrocarbons NOUN O
+( PUNCT O
+PAH NOUN O
+) PUNCT O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Statins NOUN O
+showed VERB O
+mixed ADJ O
+results NOUN O
+in ADP O
+heart NOUN B-LF
+failure NOUN I-LF
+( PUNCT O
+HF PROPN B-AC
+) PUNCT O
+patients NOUN O
+. PUNCT O
+
+Globally ADV O
+, PUNCT O
+about ADV O
+800,000 NUM O
+people NOUN O
+die VERB O
+from ADP O
+suicide NOUN O
+every DET O
+year NOUN O
+and CCONJ O
+79 NUM O
+% NOUN O
+of ADP O
+these DET O
+deaths NOUN O
+occur VERB O
+in ADP O
+low- ADJ B-LF
+and CCONJ I-LF
+middle ADJ I-LF
+- PUNCT I-LF
+income NOUN I-LF
+countries NOUN I-LF
+( PUNCT O
+LMICs PROPN B-AC
+) PUNCT O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+An DET O
+adapted ADJ O
+protocol NOUN O
+was AUX O
+applied VERB O
+following VERB O
+the DET O
+Tobacco PROPN B-LF
+Smoke PROPN I-LF
+Particles PROPN I-LF
+and CCONJ I-LF
+Indoor PROPN I-LF
+Air PROPN I-LF
+Quality PROPN I-LF
+( PUNCT O
+ToPIQ PROPN B-AC
+) PUNCT O
+studies NOUN O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+. PUNCT O
+
+G. PROPN O
+) PUNCT O
+undertook VERB O
+a DET O
+detailed ADJ O
+hand NOUN O
+search NOUN O
+focusing VERB O
+on ADP O
+the DET O
+Cochrane PROPN O
+Database PROPN O
+of ADP O
+Systematic PROPN O
+Reviews PROPN O
+and CCONJ O
+the DET O
+Database PROPN B-LF
+of ADP I-LF
+Abstracts PROPN I-LF
+of ADP I-LF
+Reviews PROPN I-LF
+of ADP I-LF
+Effects PROPN I-LF
+( PUNCT O
+DARE PROPN B-AC
+) PUNCT O
+to PART O
+identify VERB O
+systematic ADJ O
+reviews NOUN O
+that PRON O
+had AUX O
+evaluated VERB O
+adverse ADJ O
+effects NOUN O
+as ADP O
+a DET O
+primary ADJ O
+outcome NOUN O
+. PUNCT O
+
+In ADP O
+the DET O
+standard ADJ O
+- PUNCT O
+of ADP O
+- PUNCT O
+care NOUN O
+arm NOUN O
+, PUNCT O
+CHWs PROPN B-AC
+visited VERB O
+women NOUN O
+enrolled VERB O
+in ADP O
+prevention NOUN B-LF
+of ADP I-LF
+mother NOUN I-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+child NOUN I-LF
+HIV PROPN I-LF
+transmission NOUN I-LF
+( PUNCT O
+PMTCT PROPN B-AC
+) PUNCT O
+care NOUN O
+and CCONJ O
+provided VERB O
+information NOUN O
+and CCONJ O
+counseling NOUN O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+CD4 PROPN B-AC
+, PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+4 NUM I-LF
+; PUNCT O
+RUSF PROPN B-AC
+, PUNCT O
+ready ADJ B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+use VERB I-LF
+supplementary ADJ I-LF
+food NOUN I-LF
+. PUNCT O
+
+For ADP O
+each DET O
+model NOUN O
+, PUNCT O
+bivariable ADJ O
+analysis NOUN O
+with ADP O
+( PUNCT O
+crude ADJ B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+[ PUNCT O
+COR NOUN B-AC
+] PUNCT O
+) PUNCT O
+and CCONJ O
+multivariable ADJ O
+analysis NOUN O
+( PUNCT O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+[ PUNCT O
+AOR NOUN B-AC
+] PUNCT O
+) PUNCT O
+was AUX O
+used VERB O
+. PUNCT O
+
+However ADV O
+, PUNCT O
+association NOUN O
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+NLR PROPN B-AC
+elevation NOUN O
+and CCONJ O
+survival NOUN O
+outcome NOUN O
+in ADP O
+patients NOUN O
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+colorectal ADJ B-LF
+liver NOUN I-LF
+metastasis NOUN I-LF
+( PUNCT O
+CRLM PROPN B-AC
+) PUNCT O
+remains VERB O
+controversial ADJ O
+. PUNCT O
+
+IMD PROPN B-AC
+, PUNCT O
+index NOUN B-LF
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+multiple ADJ I-LF
+deprivation NOUN I-LF
+; PUNCT O
+SDS PROPN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+score NOUN I-LF
+. PUNCT O
+
+As ADP O
+a DET O
+quantitative ADJ O
+indicator NOUN O
+of ADP O
+hepatocellular ADJ O
+damage NOUN O
+, PUNCT O
+circulating VERB O
+levels NOUN O
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+alanine ADJ B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+were AUX O
+measured VERB O
+. PUNCT O
+
+GDP PROPN B-AC
+, PUNCT O
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+domestic ADJ I-LF
+product NOUN I-LF
+. PUNCT O
+
+ADME NOUN B-AC
+( PUNCT O
+absorption NOUN B-LF
+, PUNCT I-LF
+distribution NOUN I-LF
+, PUNCT I-LF
+metabolism NOUN I-LF
+, PUNCT I-LF
+excretion NOUN I-LF
+) PUNCT O
+and CCONJ O
+toxicity NOUN O
+properties NOUN O
+of ADP O
+the DET O
+obtained VERB O
+compounds NOUN O
+were AUX O
+carried VERB O
+out ADP O
+to PART O
+evaluate VERB O
+the DET O
+pharmacological ADJ O
+properties NOUN O
+of ADP O
+these DET O
+selected VERB O
+compounds NOUN O
+. PUNCT O
+
+Cohesins NOUN O
+mutated VERB O
+in ADP O
+the DET O
+Hinge PROPN O
+or CCONJ O
+Loop1 PROPN O
+regions NOUN O
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+Smc1 PROPN O
+bind VERB O
+chromatin NOUN O
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+mechanism NOUN O
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+to PART O
+wild ADJ O
+- PUNCT O
+type NOUN O
+cohesin NOUN O
+, PUNCT O
+but CCONJ O
+fail VERB O
+to PART O
+enrich VERB O
+at ADP O
+cohesin NOUN B-LF
+- PUNCT I-LF
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+regions NOUN I-LF
+( PUNCT O
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+) PUNCT O
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+pericentric ADJ O
+regions NOUN O
+. PUNCT O
+
+In ADP O
+line NOUN O
+with ADP O
+our PRON O
+results NOUN O
+, PUNCT O
+animal NOUN O
+studies NOUN O
+and CCONJ O
+studies NOUN O
+with ADP O
+smaller ADJ O
+subsets NOUN O
+of ADP O
+patients NOUN O
+with ADP O
+suspected VERB O
+pulmonary ADJ B-LF
+emboli NOUN I-LF
+have AUX O
+reported VERB O
+an DET O
+increased VERB O
+sensitivity NOUN O
+of ADP O
+DECT NOUN B-AC
+vessel NOUN O
+reconstructions NOUN O
+for ADP O
+diagnosis NOUN O
+of ADP O
+PE NOUN B-AC
+, PUNCT O
+in ADP O
+particular ADJ O
+for ADP O
+peripheral ADJ O
+emboli NOUN O
+[ PUNCT O
+8 NUM O
+, PUNCT O
+11 NUM O
+, PUNCT O
+12 NUM O
+, PUNCT O
+21 NUM O
+, PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+Unweighted ADJ O
+UniFrac PROPN O
+distance NOUN O
+metrics NOUN O
+[ X O
+45 NUM O
+] X O
+were AUX O
+generated VERB O
+and CCONJ O
+principle ADJ B-LF
+coordinate NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+PCoA NOUN B-AC
+) PUNCT O
+was AUX O
+used VERB O
+to PART O
+visualize VERB O
+the DET O
+metrics NOUN O
+. PUNCT O
+
+Funisitis NOUN O
+( PUNCT O
+inflammation NOUN O
+in ADP O
+UC PROPN B-AC
+) PUNCT O
+defined VERB O
+in ADP O
+the DET O
+presence NOUN O
+of ADP O
+neutrophil NOUN O
+infiltration NOUN O
+into ADP O
+the DET O
+umbilical ADJ O
+vessels NOUN O
+with ADP O
+or CCONJ O
+without ADP O
+the DET O
+involvement NOUN O
+of ADP O
+Wharton PROPN B-LF
+’s PART I-LF
+Jelly PROPN I-LF
+( PUNCT O
+WJ PROPN B-AC
+) PUNCT O
+in ADP O
+fetus NOUN O
+is AUX O
+known VERB O
+to PART O
+be AUX O
+the DET O
+histologic ADJ O
+hallmark NOUN O
+of ADP O
+systemic ADJ O
+fetal ADJ O
+inflammation NOUN O
+, PUNCT O
+fetal ADJ B-LF
+inflammatory ADJ I-LF
+response NOUN I-LF
+syndrome NOUN I-LF
+( PUNCT O
+FIRS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+6–8 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+registers NOUN O
+used VERB O
+in ADP O
+the DET O
+current ADJ O
+study NOUN O
+are AUX O
+listed VERB O
+as ADP O
+follows VERB O
+: PUNCT O
+The DET O
+Medical PROPN O
+Birth PROPN O
+Register PROPN O
+covers VERB O
+nearly ADV O
+all DET O
+deliveries NOUN O
+in ADP O
+Sweden PROPN O
+since SCONJ O
+1973 NUM O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+; PUNCT O
+The DET O
+Total PROPN O
+Population PROPN O
+Register PROPN O
+was AUX O
+established VERB O
+in ADP O
+1968 NUM O
+and CCONJ O
+contains VERB O
+data NOUN O
+on ADP O
+sex NOUN O
+, PUNCT O
+birth NOUN O
+, PUNCT O
+death NOUN O
+, PUNCT O
+migration NOUN O
+, PUNCT O
+and CCONJ O
+family NOUN O
+relationship NOUN O
+for ADP O
+Swedish ADJ O
+residents NOUN O
+who PRON O
+were AUX O
+born VERB O
+since SCONJ O
+1932 NUM O
+[ PUNCT O
+10 NUM O
+] PUNCT O
+; PUNCT O
+The DET O
+Multi PROPN O
+- PROPN O
+Generation PROPN O
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+, PUNCT O
+as ADP O
+part NOUN O
+of ADP O
+the DET O
+Total PROPN O
+Population PROPN O
+Register PROPN O
+, PUNCT O
+links VERB O
+individuals NOUN O
+born VERB O
+since SCONJ O
+1932 NUM O
+and CCONJ O
+registered VERB O
+as ADP O
+living VERB O
+in ADP O
+Sweden PROPN O
+since SCONJ O
+1961 NUM O
+to ADP O
+their PRON O
+biological ADJ O
+parents NOUN O
+[ PUNCT O
+11 NUM O
+] PUNCT O
+; PUNCT O
+The DET O
+longitudinal ADJ B-LF
+integration NOUN I-LF
+database NOUN I-LF
+for ADP I-LF
+health NOUN I-LF
+insurance NOUN I-LF
+and CCONJ I-LF
+labor NOUN I-LF
+market NOUN I-LF
+studies NOUN I-LF
+( PUNCT O
+LISA PROPN B-AC
+) PUNCT O
+launched VERB O
+in ADP O
+1990 NUM O
+and CCONJ O
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+annually ADV O
+updated VERB O
+data NOUN O
+on ADP O
+socioeconomic ADJ B-LF
+status NOUN I-LF
+( PUNCT O
+SES PROPN B-AC
+) PUNCT O
+such ADJ O
+as ADP O
+education NOUN O
+, PUNCT O
+civil ADJ O
+status NOUN O
+, PUNCT O
+unemployment NOUN O
+, PUNCT O
+social ADJ O
+benefits NOUN O
+, PUNCT O
+family NOUN O
+income NOUN O
+, PUNCT O
+and CCONJ O
+many ADJ O
+other ADJ O
+variables NOUN O
+for ADP O
+all DET O
+Swedish ADJ O
+residents NOUN O
+aged VERB O
+16 NUM O
+years NOUN O
+or CCONJ O
+older ADJ O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+; PUNCT O
+The DET O
+National PROPN O
+Patient PROPN O
+Register PROPN O
+covers VERB O
+inpatient NOUN O
+care NOUN O
+since SCONJ O
+1964 NUM O
+( PUNCT O
+psychiatric ADJ O
+care NOUN O
+since SCONJ O
+1973 NUM O
+) PUNCT O
+and CCONJ O
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+visits NOUN O
+to ADP O
+specialty NOUN O
+care NOUN O
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+2001 NUM O
+, PUNCT O
+with ADP O
+a DET O
+PPV NOUN B-AC
+of ADP O
+85 NUM O
+% NOUN O
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+95 NUM O
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+disorders NOUN O
+[ PUNCT O
+13 NUM O
+] PUNCT O
+; PUNCT O
+The DET O
+Prescribed PROPN O
+Drug PROPN O
+Register PROPN O
+contains VERB O
+data NOUN O
+on ADP O
+all DET O
+prescribed VERB O
+medications NOUN O
+dispensed VERB O
+at ADP O
+pharmacies NOUN O
+in ADP O
+Sweden PROPN O
+since SCONJ O
+July PROPN O
+2005 NUM O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+; PUNCT O
+Active ADJ O
+ingredients NOUN O
+of ADP O
+medications NOUN O
+are AUX O
+coded VERB O
+according VERB O
+to ADP O
+the DET O
+anatomical ADJ B-LF
+therapeutic ADJ I-LF
+chemical NOUN I-LF
+( PUNCT O
+ATC PROPN B-AC
+) PUNCT O
+classification NOUN O
+system NOUN O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+; PUNCT O
+The DET O
+National PROPN O
+Crime PROPN O
+Register PROPN O
+provides VERB O
+data NOUN O
+on ADP O
+violent ADJ O
+and CCONJ O
+nonviolent ADJ O
+crime NOUN O
+convictions NOUN O
+since SCONJ O
+1973 NUM O
+[ PUNCT O
+15 NUM O
+] PUNCT O
+. PUNCT O
+
+‡Reported VERB O
+by ADP O
+women NOUN O
+through ADP O
+audio ADJ B-LF
+computer NOUN I-LF
+- PUNCT I-LF
+assisted VERB I-LF
+self NOUN I-LF
+- PUNCT I-LF
+interview NOUN I-LF
+( PUNCT O
+ACASI PROPN B-AC
+) PUNCT O
+4 NUM O
+weeks NOUN O
+after ADP O
+enrolment NOUN O
+. PUNCT O
+
+Using VERB O
+insulin NOUN O
+- PUNCT O
+resistant ADJ O
+mice NOUN O
+deficient ADJ O
+for ADP O
+insulin NOUN B-LF
+receptor NOUN I-LF
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+2 NUM I-LF
+( PUNCT O
+Irs2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+we PRON O
+highlight VERB O
+dramatic ADJ O
+impairment NOUN O
+of ADP O
+proregenerative ADJ O
+fibroblast NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+7 NUM I-LF
+( PUNCT O
+Fgf7 PROPN B-AC
+) PUNCT O
+signaling NOUN O
+between ADP O
+stromal ADJ O
+niche NOUN O
+cells NOUN O
+and CCONJ O
+LPCs NOUN B-AC
+during ADP O
+chronic ADJ O
+injury NOUN O
+. PUNCT O
+
+Estimating VERB O
+kidney NOUN O
+glomerular ADJ B-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+GFR NOUN B-AC
+) PUNCT O
+is AUX O
+of ADP O
+utmost ADJ O
+importance NOUN O
+in ADP O
+many ADJ O
+clinical ADJ O
+conditions NOUN O
+. PUNCT O
+
+Transfusion NOUN O
+- PUNCT O
+transmissible ADJ O
+viral ADJ O
+infections NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+hepatitis NOUN B-LF
+C PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+HCV PROPN B-AC
+) PUNCT O
+, PUNCT O
+hepatitis NOUN B-LF
+B PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+HBV PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+human ADJ B-LF
+immunodeficiency NOUN I-LF
+virus NOUN I-LF
+( PUNCT O
+HIV PROPN B-AC
+) PUNCT O
+, PUNCT O
+remain VERB O
+a DET O
+major ADJ O
+public ADJ O
+health NOUN O
+problem NOUN O
+in ADP O
+developing VERB O
+countries NOUN O
+. PUNCT O
+
+The DET O
+alpha NOUN O
+- PUNCT O
+herpesvirinae NOUN O
+subfamily NOUN O
+includes VERB O
+pseudorabies NOUN B-LF
+virus NOUN I-LF
+( PUNCT O
+PRV PROPN B-AC
+) PUNCT O
+, PUNCT O
+varicella NOUN O
+- PUNCT O
+zoster NOUN O
+virus NOUN O
+, PUNCT O
+and CCONJ O
+herpes NOUN B-LF
+simplex NOUN I-LF
+virus NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+and CCONJ O
+type NOUN O
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+( PUNCT O
+HSV-1 NOUN B-AC
+and CCONJ O
+HSV-2 PROPN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+2016 NUM O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+released VERB O
+their PRON O
+first ADJ O
+global ADJ B-LF
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+sector NOUN I-LF
+strategy NOUN I-LF
+( PUNCT O
+GHSS PROPN B-AC
+) PUNCT O
+on ADP O
+viral ADJ O
+hepatitis[1 NOUN O
+] PUNCT O
+. PUNCT O
+
+BMDM PROPN B-AC
+, PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+– PUNCT I-LF
+derived VERB I-LF
+macrophage NOUN I-LF
+; PUNCT O
+DEX PROPN O
+, PUNCT O
+dexamethasone NOUN O
+; PUNCT O
+FACS PROPN O
+, PUNCT O
+fluorescence NOUN O
+- PUNCT O
+activated VERB O
+cell NOUN O
+sorting NOUN O
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+
+Nasopharyngeal ADJ B-LF
+carcinoma NOUN I-LF
+( PUNCT O
+NPC PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+rare ADJ O
+disease NOUN O
+in ADP O
+most ADJ O
+parts NOUN O
+of ADP O
+the DET O
+world NOUN O
+. PUNCT O
+
+Expression NOUN O
+values NOUN O
+for ADP O
+each DET O
+lncRNA NOUN B-AC
+are AUX O
+normalized VERB O
+to ADP O
+that PRON O
+of ADP O
+the DET O
+gene NOUN O
+encoding VERB O
+actin NOUN O
+. PUNCT O
+( PUNCT O
+D NOUN O
+) PUNCT O
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+overlap NOUN O
+in ADP O
+differentially ADV O
+expressed VERB O
+lncRNAs NOUN B-AC
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+GBMs PROPN B-AC
+and CCONJ O
+LGGs NOUN B-AC
+. PUNCT O
+GBM NOUN B-AC
+, PUNCT O
+glioblastoma NOUN B-LF
+multiforme ADJ I-LF
+; PUNCT O
+LGG NOUN B-AC
+, PUNCT O
+lower ADJ B-LF
+grade NOUN I-LF
+glioma NOUN I-LF
+; PUNCT O
+lncRNA NOUN B-AC
+, PUNCT O
+long ADJ B-LF
+noncoding VERB I-LF
+RNA NOUN I-LF
+. PUNCT O
+
+Line556 NOUN O
+: PUNCT O
+“ PUNCT O
+B. NOUN O
+proteoclastus NOUN O
+in ADP O
+the DET O
+M2I PROPN B-AC
+group NOUN O
+in ADP O
+in ADP O
+vivo ADJ O
+increased VERB O
+, PUNCT O
+This PRON O
+indicates VERB O
+low ADJ O
+concentrations NOUN O
+of ADP O
+PSM PROPN B-AC
+“ PUNCT O
+--- PUNCT O
+I PRON O
+think VERB O
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+- ADJ I-LF
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+( PUNCT O
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+and CCONJ O
+Control PROPN B-LF
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+( PUNCT O
+CI PROPN B-AC
+) PUNCT O
+low ADJ O
+concentrations NOUN O
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+PSM PROPN B-AC
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+than ADP O
+M2I PROPN B-AC
+, PUNCT O
+please INTJ O
+check VERB O
+
+A DET O
+relationship NOUN O
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+anxiety NOUN O
+- PUNCT O
+like ADJ O
+behaviour NOUN O
+and CCONJ O
+dysbiosis NOUN O
+was AUX O
+demonstrated VERB O
+by ADP O
+administering VERB O
+a DET O
+fecal ADJ B-LF
+microbiota NOUN I-LF
+transplant NOUN I-LF
+( PUNCT O
+FMT PROPN B-AC
+) PUNCT O
+at ADP O
+the DET O
+time NOUN O
+of ADP O
+injury NOUN O
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+consecutive ADJ O
+days NOUN O
+after ADP O
+SCI PROPN B-AC
+. PUNCT O
+The DET O
+FMT PROPN B-AC
+attenuated VERB O
+gut NOUN O
+dysbiosis NOUN O
+and CCONJ O
+alleviated VERB O
+SCI PROPN B-AC
+- PUNCT O
+induced VERB O
+anxiety NOUN O
+- PUNCT O
+like ADJ O
+behaviour NOUN O
+. PUNCT O
+
+Our PRON O
+preliminary ADJ O
+study NOUN O
+on ADP O
+a DET O
+Ptprz PROPN O
+- PUNCT O
+knockout NOUN B-LF
+( PUNCT O
+KO PROPN B-AC
+) PUNCT O
+mouse NOUN O
+cohort NOUN O
+that PRON O
+was AUX O
+backcrossed VERB O
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+four NUM O
+generations NOUN O
+( PUNCT O
+93.7 NUM O
+% NOUN O
+homogeneity NOUN O
+with ADP O
+the DET O
+C57BL6J PROPN O
+genetic ADJ O
+background NOUN O
+) PUNCT O
+revealed VERB O
+altered VERB O
+responsiveness NOUN O
+to ADP O
+novelty NOUN O
+and CCONJ O
+METH NOUN B-AC
+, PUNCT O
+and CCONJ O
+we PRON O
+presented VERB O
+these DET O
+results NOUN O
+at ADP O
+the DET O
+annual ADJ O
+meeting NOUN O
+of ADP O
+the DET O
+Society PROPN O
+of ADP O
+Neuroscience[14 PROPN O
+] PUNCT O
+: PUNCT O
+The DET O
+knockout NOUN B-LF
+line NOUN O
+was AUX O
+originally ADV O
+generated VERB O
+by ADP O
+gene NOUN O
+targeting NOUN O
+in ADP O
+129X1 PROPN O
+/ SYM O
+SvJ PROPN O
+ES PROPN O
+cells NOUN O
+[ PUNCT O
+15 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+fission NOUN O
+yeast NOUN O
+, PUNCT O
+the DET O
+anaphase NOUN B-LF
+- PUNCT I-LF
+promoting VERB I-LF
+complex NOUN I-LF
+/ SYM I-LF
+cyclosome NOUN I-LF
+( PUNCT O
+APC PROPN B-AC
+/ SYM B-AC
+C PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
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+initiation NOUN I-LF
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+( PUNCT O
+SIN PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+spindle NOUN B-LF
+pole NOUN I-LF
+body NOUN I-LF
+( PUNCT O
+SPB)–associated PROPN B-AC
+GTPase NOUN O
+- PUNCT O
+driven VERB O
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+, PUNCT O
+function VERB O
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+to PART O
+ensure VERB O
+proper ADJ O
+coordination NOUN O
+of ADP O
+mitosis NOUN O
+and CCONJ O
+cytokinesis NOUN O
+. PUNCT O
+
+mGFR PROPN B-AC
+, PUNCT O
+measured VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+in ADP O
+mL NOUN O
+/ SYM O
+min/1.73m2 NUM O
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+; PUNCT O
+IQR NOUN B-AC
+, PUNCT O
+interquartile ADJ B-LF
+range NOUN I-LF
+; PUNCT O
+UACR PROPN O
+, PUNCT O
+urinary ADJ O
+albumin NOUN O
+- PUNCT O
+creatinine NOUN O
+ratio NOUN O
+; PUNCT O
+HLA PROPN O
+, PUNCT O
+Human PROPN O
+leukocyte NOUN O
+antigen NOUN O
+. PUNCT O
+
+MIC PROPN B-AC
+, PUNCT O
+minimum ADJ B-LF
+inhibitory ADJ I-LF
+concentration NOUN I-LF
+. PUNCT O
+
+Although SCONJ O
+this DET O
+post ADJ B-LF
+- ADJ I-LF
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+oscillator NOUN I-LF
+( PUNCT O
+PTO PROPN B-AC
+) PUNCT O
+is AUX O
+sufficient ADJ O
+for ADP O
+generating VERB O
+rhythms NOUN O
+in ADP O
+vitro ADJ O
+, PUNCT O
+the DET O
+cyanobacterial ADJ O
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+system NOUN O
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+vivo ADJ O
+also ADV O
+includes VERB O
+a DET O
+transcriptional ADJ B-LF
+/ SYM I-LF
+translational ADJ I-LF
+feedback NOUN I-LF
+loop NOUN I-LF
+( PUNCT O
+TTFL PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+precise ADJ O
+roles NOUN O
+of ADP O
+the DET O
+PTO PROPN B-AC
+and CCONJ O
+the DET O
+TTFL PROPN B-AC
+and CCONJ O
+their PRON O
+interdependence NOUN O
+in ADP O
+forming VERB O
+the DET O
+complete ADJ O
+clock NOUN O
+system NOUN O
+in ADP O
+vivo ADJ O
+are AUX O
+unclear ADJ O
+. PUNCT O
+
+We PRON O
+analyzed VERB O
+primary ADJ O
+pure ADJ O
+unilateral ADJ O
+LCIS PROPN B-AC
+( PUNCT O
+International PROPN B-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+for ADP I-LF
+Oncology PROPN I-LF
+, PUNCT I-LF
+3rd ADJ I-LF
+edition NOUN I-LF
+[ X O
+ICD PROPN B-AC
+- PUNCT B-AC
+O-3 NUM B-AC
+] X O
+histology NOUN O
+codes NOUN O
+8520)female NUM O
+patients NOUN O
+diagnosed VERB O
+between ADP O
+January PROPN O
+1 NUM O
+, PUNCT O
+1998 NUM O
+and CCONJ O
+December PROPN O
+31 NUM O
+, PUNCT O
+2007 NUM O
+with ADP O
+no DET O
+cancer NOUN O
+history NOUN O
+that PRON O
+were AUX O
+reported VERB O
+in ADP O
+the DET O
+SEER PROPN B-AC
+18 NUM O
+Registries PROPN O
+. PUNCT O
+
+The DET O
+locus NOUN O
+pairs NOUN O
+selected VERB O
+by ADP O
+the DET O
+two NUM O
+methods NOUN O
+for ADP O
+each DET O
+given VERB O
+trait NOUN O
+were AUX O
+considered VERB O
+to PART O
+be AUX O
+equivalent ADJ O
+if SCONJ O
+the DET O
+same ADJ O
+two NUM O
+chromosomes NOUN O
+were AUX O
+identified VERB O
+and CCONJ O
+the DET O
+respective ADJ O
+chromosomal ADJ O
+locations NOUN O
+of ADP O
+the DET O
+loci NOUN O
+were AUX O
+within ADP O
+50 NUM O
+kilobases NOUN B-LF
+( PUNCT O
+kb NOUN B-AC
+) PUNCT O
+of ADP O
+each DET O
+other ADJ O
+. PUNCT O
+
+Such ADJ O
+cortical ADJ B-LF
+tracking NOUN I-LF
+of ADP I-LF
+speech NOUN I-LF
+( PUNCT O
+CTS NOUN B-AC
+) PUNCT O
+is AUX O
+thought VERB O
+to PART O
+be AUX O
+essential ADJ O
+for ADP O
+speech NOUN O
+comprehension NOUN O
+[ X O
+33,35,37,39,41–43 NUM O
+] PUNCT O
+. PUNCT O
+
+Immunoglobulin NOUN B-LF
+( PUNCT O
+Ig NOUN B-AC
+) PUNCT O
+genes NOUN O
+are AUX O
+further ADV O
+diversified VERB O
+after ADP O
+V(D)J NOUN O
+rearrangement NOUN O
+by ADP O
+gene NOUN O
+conversion NOUN O
+, PUNCT O
+hypermutation NOUN O
+, PUNCT O
+or CCONJ O
+a DET O
+combination NOUN O
+of ADP O
+the DET O
+two NUM O
+. PUNCT O
+
+In ADP O
+keeping VERB O
+with ADP O
+our PRON O
+in ADP O
+vitro ADJ O
+kinase NOUN O
+assays NOUN O
+, PUNCT O
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+found VERB O
+that PRON O
+PAK4S474E PROPN O
+robustly ADV O
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+β NOUN O
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+Ser675 NOUN O
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+cells NOUN O
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+Fig PROPN O
+6A NUM O
+) PUNCT O
+. PUNCT O
+By ADP O
+contrast NOUN O
+, PUNCT O
+we PRON O
+observed VERB O
+no DET O
+increase NOUN O
+in ADP O
+phosphorylation NOUN O
+upon SCONJ O
+coexpression NOUN O
+with ADP O
+PAK4M4 PROPN O
+/ SYM O
+S474E PROPN O
+or CCONJ O
+with ADP O
+kinase NOUN B-LF
+- PUNCT I-LF
+inactive ADJ I-LF
+mutant ADJ I-LF
+( PUNCT O
+KD PROPN B-AC
+) PUNCT O
+PAK4 PROPN O
+( PUNCT O
+PAK4D440N PROPN O
+/ SYM O
+S474E PROPN O
+) PUNCT O
+. PUNCT O
+To PART O
+examine VERB O
+substrate NOUN O
+phosphorylation NOUN O
+in ADP O
+an DET O
+endogenous ADJ O
+setting NOUN O
+, PUNCT O
+we PRON O
+performed VERB O
+experiments NOUN O
+in ADP O
+Panc1 PROPN O
+pancreatic ADJ O
+cancer NOUN O
+cells NOUN O
+that PRON O
+express VERB O
+PAK4 PROPN O
+to ADP O
+high ADJ O
+levels NOUN O
+[ PUNCT O
+52 NUM O
+] PUNCT O
+. PUNCT O
+
+Recruitment NOUN O
+of ADP O
+participants NOUN O
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+controlled VERB I-LF
+trials NOUN I-LF
+( PUNCT O
+RCTs NOUN B-AC
+) PUNCT O
+is AUX O
+critical ADJ O
+for ADP O
+successful ADJ O
+trial NOUN O
+conduct NOUN O
+. PUNCT O
+
+They PRON O
+showed VERB O
+significantly ADV O
+elevated VERB O
+mean ADJ O
+values NOUN O
+of ADP O
+triglycerides NOUN O
+compared VERB O
+with ADP O
+subjects NOUN O
+without ADP O
+the DET O
+metabolic ADJ O
+syndrome NOUN O
+, PUNCT O
+but CCONJ O
+decreased VERB O
+values NOUN O
+of ADP O
+high ADJ B-LF
+density NOUN I-LF
+lipid NOUN I-LF
+cholesterol NOUN I-LF
+( PUNCT O
+HDLC PROPN B-AC
+) PUNCT O
+. PUNCT O
+Although SCONJ O
+levels NOUN O
+of ADP O
+total ADJ O
+cholesterol NOUN O
+were AUX O
+higher ADJ O
+and CCONJ O
+consumption NOUN O
+of ADP O
+total ADJ O
+portions NOUN O
+of ADP O
+fruit NOUN O
+and CCONJ O
+vegetables NOUN O
+were AUX O
+lower ADJ O
+in ADP O
+subjects NOUN O
+with ADP O
+the DET O
+metabolic ADJ O
+syndrome NOUN O
+than ADP O
+those PRON O
+without ADP O
+, PUNCT O
+the DET O
+differences NOUN O
+were AUX O
+not PART O
+statistically ADV O
+significant ADJ O
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+50 NUM O
+μg NOUN B-AC
+/ SYM O
+mL NOUN O
+of ADP O
+propidium NOUN B-LF
+iodide NOUN I-LF
+( PUNCT O
+PI NOUN B-AC
+) PUNCT O
+was AUX O
+added VERB O
+for ADP O
+20 NUM O
+minutes NOUN O
+on ADP O
+ice NOUN O
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+
+Forced VERB B-LF
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+volume NOUN I-LF
+in ADP I-LF
+1 NUM I-LF
+sec NOUN I-LF
+( PUNCT O
+FEV1 NOUN B-AC
+) PUNCT O
+( PUNCT O
+% PUNCT O
+predicted VERB O
+) PUNCT O
+and CCONJ O
+FEV1 NOUN B-AC
+/ SYM O
+forced VERB B-LF
+vital ADJ I-LF
+capacity NOUN I-LF
+( PUNCT O
+FVC PROPN B-AC
+) PUNCT O
+ratio NOUN O
+were AUX O
+significantly ADV O
+lower ADJ O
+in ADP O
+subjects NOUN O
+with ADP O
+severe ADJ O
+compared VERB O
+to ADP O
+mild ADJ O
+/ SYM O
+moderate ADJ O
+asthma NOUN O
+. PUNCT O
+
+Heart NOUN B-LF
+failure NOUN I-LF
+with ADP I-LF
+reduced ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+( PUNCT O
+HFrEF PROPN B-AC
+; PUNCT O
+left ADJ O
+ventricular ADJ O
+ejection NOUN O
+fraction NOUN O
+< ADP O
+45 NUM O
+% PUNCT O
+) PUNCT O
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+a DET O
+potential ADJ O
+end NOUN O
+- NOUN O
+stage NOUN O
+of ADP O
+various ADJ O
+cardiac ADJ O
+diseases NOUN O
+and CCONJ O
+represents VERB O
+an DET O
+enormous ADJ O
+public ADJ O
+health NOUN O
+and CCONJ O
+socioeconomic ADJ O
+burden NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+To PART O
+examine VERB O
+the DET O
+resolution NOUN O
+at ADP O
+which PRON O
+illness NOUN O
+might AUX O
+be AUX O
+confidently ADV O
+identified VERB O
+, PUNCT O
+we PRON O
+developed VERB O
+a DET O
+computational ADJ O
+approach NOUN O
+called VERB O
+“ PUNCT O
+Change PROPN B-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+Heart NOUN I-LF
+” PUNCT O
+or CCONJ O
+COH PROPN B-AC
+to PART O
+identify VERB O
+periods NOUN O
+with ADP O
+abnormal ADJ O
+HR NOUN B-AC
+patterns NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+TNFi PROPN B-AC
+, PUNCT O
+tumour NOUN O
+necrosis NOUN O
+factor NOUN O
+inhibitor NOUN O
+. PUNCT O
+
+DIMM PROPN B-AC
+, PUNCT O
+dual ADJ B-LF
+input NOUN I-LF
+Mother PROPN I-LF
+Machine PROPN I-LF
+. PUNCT O
+
+1 X O
+. PUNCT O
+The DET O
+topic NOUN O
+of ADP O
+the DET O
+manuscript NOUN O
+is AUX O
+“ PUNCT O
+Prostate PROPN B-LF
+- PUNCT I-LF
+Specific PROPN I-LF
+Antigen PROPN I-LF
+Dynamics PROPN O
+After ADP O
+Carbon PROPN B-LF
+Ion NOUN I-LF
+Radiotherapy PROPN I-LF
+for ADP O
+Prostate PROPN O
+Cancer PROPN O
+. PUNCT O
+” PUNCT O
+If SCONJ O
+the DET O
+authors NOUN O
+were AUX O
+not PART O
+able ADJ O
+to ADP O
+confirm VERB O
+whether SCONJ O
+the DET O
+PSA NOUN B-AC
+dynamics NOUN O
+was AUX O
+due ADJ O
+to ADP O
+the DET O
+effect NOUN O
+of ADP O
+CIRT PROPN B-AC
+, PUNCT O
+ADT PROPN B-AC
+or CCONJ O
+both PRON O
+, PUNCT O
+the DET O
+issue NOUN O
+of ADP O
+this DET O
+investigation NOUN O
+should AUX O
+be AUX O
+“ PUNCT O
+Prostate PROPN B-LF
+- PUNCT I-LF
+Specific PROPN I-LF
+Antigen PROPN I-LF
+Dynamics PROPN O
+After ADP O
+Neoadjuvant PROPN O
+ADT PROPN B-AC
+and CCONJ O
+CIRT PROPN B-AC
+for ADP O
+Prostate PROPN O
+Cancer PROPN O
+. PUNCT O
+” PUNCT O
+Precisely ADV O
+, PUNCT O
+the DET O
+study NOUN O
+demonstrated VERB O
+the DET O
+prostate NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+antigen NOUN I-LF
+dynamics NOUN O
+after ADP O
+neoadjuvant ADJ O
+androgen NOUN B-LF
+- PUNCT I-LF
+deprivation NOUN I-LF
+therapy NOUN I-LF
+combined VERB O
+with ADP O
+carbon NOUN B-LF
+ion NOUN I-LF
+radiotherapy NOUN I-LF
+for ADP O
+intermediate ADJ O
+risk NOUN O
+prostate NOUN O
+cancer NOUN O
+patients NOUN O
+. PUNCT O
+
+Patients NOUN O
+with ADP O
+a DET O
+clinical ADJ O
+suspect NOUN O
+of ADP O
+ACD PROPN B-AC
+or CCONJ O
+SNAS PROPN B-AC
+that PRON O
+met VERB O
+inclusion NOUN O
+and CCONJ O
+exclusion NOUN O
+criteria NOUN O
+were AUX O
+patch NOUN O
+tested VERB O
+with ADP O
+the DET O
+Società PROPN B-LF
+Italiana PROPN I-LF
+Dermatologia PROPN I-LF
+Allergologica PROPN I-LF
+Professionale PROPN I-LF
+ed PROPN I-LF
+Ambientale PROPN I-LF
+( PUNCT O
+SIDAPA PROPN B-AC
+) PUNCT O
+baseline NOUN O
+series NOUN O
+( PUNCT O
+Lofarma PROPN O
+S.p PROPN O
+. PUNCT O
+A. PROPN O
+, PUNCT O
+Milano PROPN O
+, PUNCT O
+Italy PROPN O
+) PUNCT O
+, PUNCT O
+that PRON O
+assess VERB O
+Ni PROPN B-AC
+sensitivity NOUN O
+with ADP O
+a DET O
+5 NUM O
+% NOUN O
+Nickel PROPN B-LF
+Sulfate PROPN O
+solution NOUN O
+. PUNCT O
+
+NK PROPN B-AC
+, PUNCT O
+natural ADJ B-LF
+killer NOUN I-LF
+; PUNCT O
+7KC PROPN B-AC
+, PUNCT O
+7 NUM B-LF
+- PUNCT I-LF
+ketocholesterol NOUN I-LF
+. PUNCT O
+
+ROI NOUN B-AC
+, PUNCT O
+return NOUN B-LF
+on ADP I-LF
+investment NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+ACTOMgSO4 PROPN B-AC
+, PUNCT O
+Australasian PROPN B-LF
+Collaborative PROPN I-LF
+Trial PROPN I-LF
+of ADP I-LF
+Magnesium PROPN I-LF
+Sulphate PROPN I-LF
+; PUNCT O
+BEAM PROPN B-AC
+, PUNCT O
+Beneficial PROPN B-LF
+Effects PROPN I-LF
+of ADP I-LF
+Antenatal PROPN I-LF
+Magnesium PROPN I-LF
+Sulfate PROPN I-LF
+; PUNCT O
+MAGNET PROPN B-AC
+, PUNCT O
+Magnesium PROPN B-LF
+and CCONJ I-LF
+Neurologic PROPN I-LF
+Endpoints PROPN I-LF
+Trial PROPN I-LF
+; PUNCT O
+MAGPIE PROPN B-AC
+, PUNCT O
+MAGnesium PROPN B-LF
+sulphate NOUN I-LF
+for ADP I-LF
+Prevention PROPN I-LF
+of ADP I-LF
+Eclampsia PROPN I-LF
+; PUNCT O
+PREMAG PROPN B-AC
+, PUNCT O
+PREterm PROPN O
+brain NOUN O
+protection NOUN O
+by ADP O
+MAGnesium PROPN O
+. PUNCT O
+
+To PART O
+test VERB O
+this DET O
+possibility NOUN O
+, PUNCT O
+we PRON O
+grew VERB O
+eDR5::LUC NOUN B-AC
+plants NOUN O
+on ADP O
+media NOUN O
+containing VERB O
+N-1 NOUN B-LF
+- PUNCT I-LF
+naphthylphthalamic ADJ I-LF
+acid NOUN I-LF
+( PUNCT O
+NPA PROPN B-AC
+) PUNCT O
+, PUNCT O
+an DET O
+inhibitor NOUN O
+of ADP O
+the DET O
+auxin NOUN O
+transport NOUN O
+machinery NOUN O
+. PUNCT O
+
+Underlying VERB O
+numerical ADJ O
+values NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S16 PROPN O
+Data PROPN O
+. PUNCT O
+nEZ PROPN B-AC
+, PUNCT O
+nonepileptogenic ADJ B-LF
+zone NOUN I-LF
+; PUNCT O
+RZ PROPN B-AC
+, PUNCT O
+resected VERB B-LF
+zone NOUN I-LF
+; PUNCT O
+SOZ PROPN B-AC
+, PUNCT O
+seizure NOUN B-LF
+- PUNCT I-LF
+onset NOUN I-LF
+zone NOUN I-LF
+. PUNCT O
+
+We PRON O
+showed VERB O
+that SCONJ O
+PDGF PROPN B-AC
+signaling NOUN O
+primarily ADV O
+activates VERB O
+the DET O
+Phosphoinositide NOUN B-LF
+3 NUM I-LF
+- PUNCT I-LF
+kinase PROPN I-LF
+( PUNCT O
+PI3K)–Protein PROPN B-LF
+kinase PROPN I-LF
+B PROPN I-LF
+( PUNCT O
+AKT PROPN B-AC
+) PUNCT O
+pathway NOUN O
+in ADP O
+lens NOUN O
+development NOUN O
+and CCONJ O
+the DET O
+direct ADJ O
+binding NOUN O
+of ADP O
+PI3 PROPN B-AC
+K PROPN B-AC
+to ADP O
+PDGFRα PROPN B-AC
+is AUX O
+required VERB O
+for ADP O
+preventing VERB O
+the DET O
+depletion NOUN O
+of ADP O
+lens NOUN O
+epithelial ADJ O
+cells NOUN O
+. PUNCT O
+
+We PRON O
+quantified VERB O
+radial ADJ O
+sorting VERB O
+defects NOUN O
+in ADP O
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+day NOUN I-LF
+16 NUM I-LF
+( PUNCT O
+P16 PROPN B-AC
+) PUNCT O
+because SCONJ O
+Lama2−/− NOUN O
+mice NOUN O
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+the DET O
+C57 PROPN O
+/ SYM O
+BL6 PROPN O
+background NOUN O
+die VERB O
+around ADP O
+P21 PROPN O
+. PUNCT O
+
+ACEI PROPN B-AC
+, PUNCT O
+angiotensin NOUN B-LF
+- PUNCT I-LF
+converting VERB I-LF
+enzyme NOUN I-LF
+inhibitor NOUN I-LF
+; PUNCT O
+ARB PROPN B-AC
+, PUNCT O
+angiotensin NOUN B-LF
+II NUM I-LF
+receptor NOUN I-LF
+blocker NOUN I-LF
+. PUNCT O
+
+Total ADJ B-LF
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+arthroplasty NOUN I-LF
+( PUNCT O
+TKA NOUN B-AC
+) PUNCT O
+is AUX O
+often ADV O
+performed VERB O
+in ADP O
+the DET O
+late ADJ O
+stage NOUN O
+of ADP O
+knee NOUN O
+arthritis NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+SD NOUN O
+: PUNCT O
+Standard ADJ O
+deviation NOUN O
+, PUNCT O
+LVIDd NOUN O
+: PUNCT O
+Left ADJ O
+ventricular ADJ O
+internal ADJ O
+diameter NOUN O
+in ADP O
+diastole NOUN O
+, PUNCT O
+LVPWd NOUN O
+: PUNCT O
+Posterior ADJ O
+wall NOUN O
+thickness NOUN O
+in ADP O
+diastole NOUN O
+, PUNCT O
+IVSd NOUN O
+: PUNCT O
+Septum NOUN O
+wall NOUN O
+thickness NOUN O
+in ADP O
+diastole NOUN O
+, PUNCT O
+LVMI NOUN B-AC
+: PUNCT O
+Left ADJ B-LF
+ventricular ADJ I-LF
+mass NOUN I-LF
+index NOUN I-LF
+, PUNCT O
+LAVI PROPN B-AC
+: PUNCT O
+Left ADJ B-LF
+atrium NOUN I-LF
+volume NOUN I-LF
+index NOUN I-LF
+. PUNCT O
+
+In ADP O
+the DET O
+tested VERB O
+samples NOUN O
+of ADP O
+6,017 NUM O
+PMC PROPN B-AC
+articles NOUN O
+, PUNCT O
+the DET O
+accuracy NOUN O
+, PUNCT O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+PPV NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+negative ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+NPV NOUN B-AC
+) PUNCT O
+of ADP O
+all DET O
+5 NUM O
+algorithms NOUN O
+was AUX O
+≥88 NUM O
+% NOUN O
+( PUNCT O
+Fig PROPN O
+2 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+then ADV O
+integrated VERB O
+these DET O
+AD PROPN B-AC
+- PUNCT O
+associated VERB O
+SNPs NOUN B-AC
+into ADP O
+a DET O
+Cox PROPN O
+proportional ADJ O
+hazard NOUN O
+model NOUN O
+using VERB O
+genotype NOUN O
+data NOUN O
+from ADP O
+a DET O
+subset NOUN O
+of ADP O
+6,409 NUM O
+AD PROPN B-AC
+patients NOUN O
+and CCONJ O
+9,386 NUM O
+older ADJ O
+controls NOUN O
+from ADP O
+Phase PROPN O
+1 NUM O
+of ADP O
+the DET O
+Alzheimer PROPN B-LF
+’s PART I-LF
+Disease PROPN I-LF
+Genetics PROPN I-LF
+Consortium PROPN I-LF
+( PUNCT O
+ADGC PROPN B-AC
+) PUNCT O
+, PUNCT O
+providing VERB O
+a DET O
+polygenic ADJ B-LF
+hazard NOUN I-LF
+score NOUN I-LF
+( PUNCT O
+PHS PROPN B-AC
+) PUNCT O
+for ADP O
+each DET O
+participant NOUN O
+. PUNCT O
+
+While SCONJ O
+some DET O
+Hh PROPN B-AC
+co VERB O
+- PUNCT O
+fractionates NOUN O
+with ADP O
+residual ADJ O
+Lpp PROPN B-AC
+, PUNCT O
+most ADJ O
+is AUX O
+present ADJ O
+in ADP O
+dense ADJ O
+fractions NOUN O
+that PRON O
+do AUX O
+not PART O
+contain VERB O
+apoLII NOUN B-AC
+, PUNCT O
+a DET O
+scaffolding NOUN O
+protein NOUN O
+of ADP O
+Lpp PROPN B-AC
+( PUNCT O
+Figure PROPN O
+2C NUM O
+) PUNCT O
+. PUNCT O
+Reduced VERB O
+sterol NOUN O
+levels NOUN O
+can AUX O
+not PART O
+account VERB O
+for ADP O
+the DET O
+appearance NOUN O
+of ADP O
+high ADJ O
+- PUNCT O
+density NOUN O
+Hh PROPN B-AC
+, PUNCT O
+because SCONJ O
+dietary ADJ O
+sterol NOUN O
+depletion NOUN O
+does AUX O
+not PART O
+produce VERB O
+this DET O
+phenotype NOUN O
+( PUNCT O
+Figure PROPN O
+S3E NUM O
+, PUNCT O
+F NUM O
+) PUNCT O
+. PUNCT O
+In ADP O
+addition NOUN O
+to ADP O
+Lpp PROPN B-AC
+, PUNCT O
+Drosophila PROPN O
+hemolymph NOUN O
+contains VERB O
+two NUM O
+minor ADJ O
+lipoproteins NOUN O
+of ADP O
+higher ADJ O
+density NOUN O
+, PUNCT O
+Lipid PROPN B-LF
+Transfer PROPN I-LF
+Particle PROPN I-LF
+( PUNCT O
+LTP PROPN B-AC
+) PUNCT O
+and CCONJ O
+Crossveinless PROPN B-LF
+- PUNCT I-LF
+d PROPN I-LF
+( PUNCT O
+Cv PROPN B-AC
+- PUNCT B-AC
+d PROPN B-AC
+) PUNCT O
+[ PUNCT O
+26 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+serum NOUN O
+iohexol NOUN O
+concentration NOUN O
+was AUX O
+measured VERB O
+by ADP O
+High PROPN B-LF
+Performance PROPN I-LF
+Liquid PROPN I-LF
+Chromatography PROPN I-LF
+( PUNCT O
+HPLC PROPN B-AC
+) PUNCT O
+. PUNCT O
+External ADJ O
+quality NOUN O
+control NOUN O
+was AUX O
+provided VERB O
+by ADP O
+Equalis PROPN O
+( PUNCT O
+Uppsala PROPN O
+, PUNCT O
+Sweden PROPN O
+) PUNCT O
+every DET O
+3 NUM O
+months NOUN O
+. PUNCT O
+
+Note VERB O
+: PUNCT O
+Multistate ADJ O
+models NOUN O
+of ADP O
+104,719 NUM O
+patients NOUN O
+on ADP O
+first ADJ O
+- PUNCT O
+line NOUN O
+ART PROPN B-AC
+. PUNCT O
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+treatment NOUN I-LF
+; PUNCT O
+ITT PROPN O
+, PUNCT O
+intention NOUN O
+- PUNCT O
+to PART O
+- PUNCT O
+treat VERB O
+; PUNCT O
+LTFU PROPN B-AC
+, PUNCT O
+loss NOUN B-LF
+to PART I-LF
+follow VERB I-LF
+- PUNCT I-LF
+up ADP I-LF
+; PUNCT O
+OT PROPN O
+, PUNCT O
+on ADP O
+- PUNCT O
+treatment NOUN O
+; PUNCT O
+VL PROPN B-AC
+, PUNCT O
+viral ADJ O
+load NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+NA PROPN O
+, PUNCT O
+not PART O
+applicable ADJ O
+; PUNCT O
+SEHER PROPN B-AC
+, PUNCT O
+Strengthening VERB B-LF
+Evidence NOUN I-LF
+base NOUN I-LF
+on ADP I-LF
+scHool NOUN I-LF
+- PUNCT I-LF
+based VERB I-LF
+intErventions NOUN I-LF
+for ADP I-LF
+pRomoting VERB I-LF
+adolescent ADJ I-LF
+health NOUN I-LF
+; PUNCT O
+SM PROPN B-AC
+, PUNCT O
+SEHER PROPN B-LF
+Mitra PROPN I-LF
+; PUNCT O
+TSM PROPN B-AC
+, PUNCT O
+Teacher NOUN B-LF
+as ADP I-LF
+SEHER PROPN I-LF
+Mitra PROPN I-LF
+
+LTFU PROPN B-AC
+, PUNCT O
+loss NOUN B-LF
+to ADP I-LF
+follow NOUN I-LF
+- PUNCT I-LF
+up ADP I-LF
+; PUNCT O
+TS PROPN B-AC
+, PUNCT O
+treatment NOUN B-LF
+success NOUN I-LF
+. PUNCT O
+
+CPXV203 PROPN O
+/ SYM O
+Kb NOUN O
+mutations NOUN O
+that PRON O
+significantly ADV O
+increased VERB O
+surface NOUN O
+Kb NOUN O
+expression NOUN O
+also ADV O
+exhibited VERB O
+a DET O
+decrease NOUN O
+in ADP O
+total ADJ O
+Kb NOUN O
+( PUNCT O
+lysate NOUN O
+) PUNCT O
+, PUNCT O
+indicative ADJ O
+of ADP O
+the DET O
+release NOUN O
+of ADP O
+MHCI PROPN B-AC
+retention NOUN O
+[ X O
+28 NUM O
+] PUNCT O
+. PUNCT O
+( PUNCT O
+E NOUN O
+) PUNCT O
+Kinetic ADJ O
+analysis NOUN O
+( PUNCT O
+SPR PROPN B-AC
+) PUNCT O
+of ADP O
+alanine ADJ O
+mutation NOUN O
+of ADP O
+α3 NOUN O
+interface NOUN O
+histidines NOUN O
+( PUNCT O
+CPXV203 PROPN O
+H75 PROPN O
+and CCONJ O
+H80 PROPN O
+) PUNCT O
+summarized VERB O
+by ADP O
+on NOUN B-LF
+- PUNCT I-LF
+rate NOUN I-LF
+( PUNCT O
+ka NOUN B-AC
+, PUNCT O
+( PUNCT O
++ PUNCT O
+) PUNCT O
+-axis NOUN O
+) PUNCT O
+and CCONJ O
+half ADJ O
+- PUNCT O
+life NOUN O
+( PUNCT O
+half ADJ O
+- PUNCT O
+life NOUN O
+, PUNCT O
+( PUNCT O
+−)-axis NOUN O
+) PUNCT O
+. PUNCT O
+( PUNCT O
+F NOUN O
+) PUNCT O
+Summary NOUN O
+of ADP O
+mutagenic ADJ O
+analysis NOUN O
+( PUNCT O
+functional ADJ O
+and CCONJ O
+biosensor ADJ O
+) PUNCT O
+mapped VERB O
+to ADP O
+CPXV203 PROPN O
+/ SYM O
+MHCI PROPN B-AC
+structure NOUN O
+( PUNCT O
+same ADJ O
+colors NOUN O
+as ADP O
+Figure NOUN O
+3A NUM O
+) PUNCT O
+shown VERB O
+as ADP O
+cartoon NOUN O
+loops NOUN O
+except SCONJ O
+for ADP O
+the DET O
+peptide NOUN O
+( PUNCT O
+spheres NOUN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+a DET O
+subset NOUN O
+of ADP O
+ROS PROPN B-AC
+, PUNCT O
+MAP PROPN B-AC
+, PUNCT O
+and CCONJ O
+MARS PROPN B-AC
+participants NOUN O
+, PUNCT O
+serum ADJ O
+thyroid NOUN B-LF
+stimulating VERB I-LF
+hormone NOUN I-LF
+( PUNCT O
+TSH PROPN B-AC
+) PUNCT O
+levels NOUN O
+were AUX O
+assessed VERB O
+by ADP O
+immunoassay NOUN O
+by ADP O
+Quest PROPN O
+Diagnostics PROPN O
+( PUNCT O
+Madison PROPN O
+, PUNCT O
+NJ PROPN O
+, PUNCT O
+US PROPN O
+) PUNCT O
+. PUNCT O
+
+ADQoL PROPN B-AC
+, PUNCT O
+Atopic PROPN B-LF
+Dermatitis PROPN I-LF
+Quality PROPN I-LF
+of ADP I-LF
+Life PROPN I-LF
+; PUNCT O
+CHU-9D PROPN O
+, PUNCT O
+Child PROPN O
+Health PROPN O
+Utility PROPN O
+9 NUM O
+Dimensions NOUN O
+; PUNCT O
+DFI PROPN B-AC
+, PUNCT O
+Dermatitis PROPN B-LF
+Family PROPN I-LF
+Impact PROPN I-LF
+; PUNCT O
+N NOUN O
+/ SYM O
+A NOUN O
+, PUNCT O
+not PART O
+applicable ADJ O
+; PUNCT O
+SD NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+Based VERB O
+on ADP O
+the DET O
+immunoprecipitation NOUN O
+sequencing NOUN O
+data NOUN O
+( PUNCT O
+S14A PROPN O
+Fig PROPN O
+, PUNCT O
+S5 PROPN O
+Table PROPN O
+) PUNCT O
+, PUNCT O
+together ADV O
+with ADP O
+target NOUN O
+prediction NOUN O
+( PUNCT O
+S14B PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+luciferase NOUN O
+reporter NOUN O
+assay NOUN O
+( PUNCT O
+S14C PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+QRT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+analysis NOUN O
+( PUNCT O
+S14D PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+we PRON O
+found VERB O
+that SCONJ O
+inhibin NOUN B-LF
+subunit NOUN I-LF
+beta NOUN I-LF
+A NOUN I-LF
+( PUNCT O
+Inhba PROPN B-AC
+) PUNCT O
+and CCONJ O
+DNA NOUN B-LF
+methyltransferase NOUN I-LF
+3 NUM I-LF
+alpha NOUN I-LF
+( PUNCT O
+Dnmt3a PROPN B-AC
+) PUNCT O
+act VERB O
+as ADP O
+direct ADJ O
+targets NOUN O
+of ADP O
+miR-26a NOUN O
+. PUNCT O
+
+Mean ADJ O
+LVMI PROPN B-AC
+was AUX O
+82.7 NUM O
+± SYM O
+30.6 NUM O
+and CCONJ O
+145 NUM O
+patients NOUN O
+had VERB O
+late ADJ B-LF
+gadolinium NOUN I-LF
+enhancement NOUN I-LF
+( PUNCT O
+LGE PROPN B-AC
+) PUNCT O
+. PUNCT O
+Patients NOUN O
+with ADP O
+beta NOUN B-LF
+- PUNCT I-LF
+myosin NOUN I-LF
+heavy ADJ I-LF
+chain NOUN I-LF
+( PUNCT O
+MYH7 PROPN B-AC
+) PUNCT O
+mutations NOUN O
+had VERB O
+higher ADJ O
+LV PROPN B-AC
+ejection NOUN O
+fraction NOUN O
+( PUNCT O
+68.8 NUM O
+vs ADP O
+59.1 NUM O
+, PUNCT O
+p<0.001 NUM O
+) PUNCT O
+than ADP O
+those PRON O
+with ADP O
+cardiac ADJ B-LF
+myosin NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+C PROPN I-LF
+( PUNCT O
+MYBPC3 PROPN B-AC
+) PUNCT O
+mutations NOUN O
+. PUNCT O
+
+Malnutrition NOUN O
+was AUX O
+defined VERB O
+for ADP O
+patients NOUN O
+< ADP O
+5 NUM O
+years NOUN O
+old ADJ O
+as ADP O
+a DET O
+mid ADJ O
+- NOUN O
+upper ADJ O
+arm NOUN O
+circumference NOUN O
+< ADP O
+115 NUM O
+mm NOUN O
+, PUNCT O
+in ADP O
+patients NOUN O
+aged VERB O
+≥5 NUM O
+years NOUN O
+to ADP O
+≤19 NUM O
+years NOUN O
+using VERB O
+the DET O
+World PROPN O
+Health PROPN O
+Organization PROPN O
+age- NOUN O
+and CCONJ O
+sex NOUN O
+- NOUN O
+specific ADJ O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI)-for NOUN B-AC
+- NOUN O
+age NOUN O
+z NOUN O
+- NOUN O
+scores NOUN O
+[ PUNCT O
+24 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+for ADP O
+adults NOUN O
+> NUM O
+19 NUM O
+years NOUN O
+old ADJ O
+as ADP O
+a DET O
+BMI NOUN B-AC
+< ADP O
+18.5 NUM O
+kg NOUN O
+/ SYM O
+m2 NOUN O
+. PUNCT O
+
+d X O
+SCNT PROPN B-AC
+: PUNCT O
+somatic ADJ B-LF
+cell NOUN I-LF
+nuclear ADJ I-LF
+transfer NOUN I-LF
+. PUNCT O
+
+This DET O
+dysbiosis NOUN O
+translated VERB O
+into ADP O
+420 NUM O
+different ADJ O
+operational ADJ B-LF
+taxonomic ADJ I-LF
+units NOUN I-LF
+( PUNCT O
+OTUs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+IVH PROPN B-AC
+, PUNCT O
+intraventricular ADJ B-LF
+haemorrhage NOUN I-LF
+; PUNCT O
+ICH PROPN O
+, PUNCT O
+intracerebral ADJ O
+haemorrhage NOUN O
+; PUNCT O
+PVH NOUN O
+, PUNCT O
+periventricular ADJ O
+haemorrhage NOUN O
+; PUNCT O
+PVL PROPN B-AC
+, PUNCT O
+periventricular ADJ B-LF
+leukomalacia NOUN I-LF
+. PUNCT O
+
+The DET O
+goal NOUN O
+of ADP O
+this DET O
+study NOUN O
+is AUX O
+to ADP O
+address VERB O
+these DET O
+2 NUM O
+challenges NOUN O
+related VERB O
+to ADP O
+neural ADJ O
+encoding NOUN O
+in ADP O
+the DET O
+cortex NOUN O
+by ADP O
+focusing VERB O
+on ADP O
+a DET O
+subject NOUN O
+that PRON O
+has AUX O
+already ADV O
+been AUX O
+well ADV O
+- PUNCT O
+studied VERB O
+: PUNCT O
+the DET O
+encoding NOUN O
+of ADP O
+rodent ADJ O
+socialization NOUN O
+by ADP O
+neurons NOUN O
+in ADP O
+the DET O
+medial ADJ B-LF
+prefrontal ADJ I-LF
+cortex NOUN I-LF
+( PUNCT O
+mPFC PROPN B-AC
+) PUNCT O
+[ X O
+17–20 NUM O
+] PUNCT O
+. PUNCT O
+
+DWV PROPN B-AC
+, PUNCT O
+deformed VERB B-LF
+wing NOUN I-LF
+virus NOUN I-LF
+; PUNCT O
+IRES PROPN B-AC
+, PUNCT O
+internal ADJ B-LF
+ribosome NOUN I-LF
+entry NOUN I-LF
+site NOUN I-LF
+; PUNCT O
+LP PROPN B-AC
+, PUNCT O
+leader NOUN B-LF
+protein NOUN I-LF
+; PUNCT O
+NGS PROPN B-AC
+, PUNCT O
+next ADJ B-LF
+- PUNCT I-LF
+generation NOUN I-LF
+sequencing NOUN I-LF
+; PUNCT O
+Prot PROPN O
+, PUNCT O
+viral ADJ O
+protease NOUN O
+; PUNCT O
+RdRpol PROPN B-AC
+, PUNCT O
+RNA NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+RNA NOUN I-LF
+polymerase NOUN I-LF
+; PUNCT O
+RNAi PROPN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT O
+small ADJ O
+interfering VERB O
+RNA NOUN O
+; PUNCT O
+VP PROPN B-AC
+, PUNCT O
+structural ADJ B-LF
+viral ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+report VERB O
+that SCONJ O
+αSacetyl NOUN B-AC
+is AUX O
+more ADV O
+effective ADJ O
+at ADP O
+inducing VERB O
+intracellular ADJ O
+aggregation NOUN O
+in ADP O
+primary ADJ O
+neurons NOUN O
+than ADP O
+unmodified ADJ B-LF
+αS NOUN I-LF
+( PUNCT O
+αSun PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+LN NOUN B-AC
+, PUNCT O
+Lymph NOUN B-LF
+node NOUN I-LF
+; PUNCT O
+PT NOUN B-AC
+, PUNCT O
+Primary ADJ B-LF
+tumor NOUN I-LF
+; PUNCT O
+ER NOUN B-AC
+, PUNCT O
+estrogen NOUN B-LF
+receptor NOUN I-LF
+; PUNCT O
+PR NOUN B-AC
+, PUNCT O
+progesterone NOUN B-LF
+receptor NOUN I-LF
+; PUNCT O
+
+We PRON O
+fitted VERB O
+weighted VERB O
+Cox PROPN O
+proportional ADJ O
+hazards NOUN O
+models NOUN O
+using VERB O
+the DET O
+inverse ADJ B-LF
+probability NOUN I-LF
+of ADP I-LF
+treatment NOUN I-LF
+weighting NOUN I-LF
+( PUNCT O
+IPTW PROPN B-AC
+) PUNCT O
+[ PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+COPD PROPN B-AC
+, PUNCT O
+chronic ADJ B-LF
+obstructive ADJ I-LF
+pulmonary ADJ I-LF
+disease NOUN I-LF
+; PUNCT O
+PPV23 PROPN B-AC
+, PUNCT O
+23 NUM B-LF
+- PUNCT I-LF
+valent NOUN I-LF
+pneumococcal NOUN I-LF
+polysaccharide NOUN I-LF
+vaccine NOUN I-LF
+. PUNCT O
+
+PACE PROPN B-AC
+- PUNCT B-AC
+Lift NOUN B-AC
+, PUNCT O
+Pedometer NOUN B-LF
+Accelerometer NOUN I-LF
+Consultation PROPN I-LF
+Evaluation PROPN I-LF
+- PUNCT I-LF
+Lift NOUN I-LF
+; PUNCT O
+PACE PROPN B-AC
+- PUNCT B-AC
+UP PROPN B-AC
+, PUNCT O
+Pedometer NOUN B-LF
+And CCONJ I-LF
+Consultation PROPN I-LF
+Evaluation PROPN I-LF
+- PUNCT I-LF
+UP PROPN I-LF
+. PUNCT O
+
+The DET O
+method NOUN O
+of ADP O
+determination NOUN O
+of ADP O
+8 NUM B-LF
+- PUNCT I-LF
+isoprostanes NOUN I-LF
+( PUNCT O
+8 NUM B-AC
+- PUNCT B-AC
+EPI NOUN B-AC
+) PUNCT O
+in ADP O
+biological ADJ O
+samples NOUN O
+has AUX O
+been AUX O
+described VERB O
+and CCONJ O
+accepted VERB O
+( PUNCT O
+BIOXYTECH PROPN O
+8 NUM O
+- PUNCT O
+Isoprostane NOUN O
+Assay PROPN O
+, PUNCT O
+Cat PROPN O
+. PUNCT O
+
+If SCONJ O
+a DET O
+fraction NOUN O
+of ADP O
+ISWI PROPN O
+is AUX O
+PARylated VERB B-AC
+in ADP O
+vivo ADJ O
+, PUNCT O
+we PRON O
+might AUX O
+expect VERB O
+this DET O
+level NOUN O
+to PART O
+increase VERB O
+when SCONJ O
+the DET O
+activity NOUN O
+of ADP O
+PARP PROPN B-AC
+is AUX O
+not PART O
+counterbalanced VERB O
+by ADP O
+the DET O
+action NOUN O
+of ADP O
+PARG PROPN B-AC
+, PUNCT O
+the DET O
+poly ADJ B-LF
+- PUNCT I-LF
+ADP NOUN I-LF
+- PUNCT I-LF
+ribose NOUN I-LF
+glycohydrolase NOUN I-LF
+that PRON O
+reverses VERB O
+the DET O
+enzymatic ADJ O
+activity NOUN O
+of ADP O
+PARP PROPN B-AC
+[ PUNCT O
+17,18 NUM O
+] PUNCT O
+. PUNCT O
+
+Indeed ADV O
+, PUNCT O
+many ADJ O
+people NOUN O
+living VERB O
+in ADP O
+the DET O
+US PROPN O
+and CCONJ O
+Europe PROPN O
+( PUNCT O
+in ADP O
+particular ADJ O
+, PUNCT O
+elderly ADJ O
+people NOUN O
+, PUNCT O
+breastfed VERB O
+infants NOUN O
+, PUNCT O
+people NOUN O
+with ADP O
+dark ADJ O
+skin NOUN O
+, PUNCT O
+and CCONJ O
+obese ADJ O
+individuals NOUN O
+) PUNCT O
+have VERB O
+serum NOUN O
+( PUNCT O
+circulating VERB O
+) PUNCT O
+25 NUM B-LF
+- PUNCT I-LF
+hydroxy NOUN I-LF
+- PUNCT I-LF
+vitamin NOUN I-LF
+D NOUN I-LF
+( PUNCT O
+25OHD NOUN B-AC
+) PUNCT O
+levels NOUN O
+below ADP O
+50 NUM O
+nmol NOUN O
+/ SYM O
+l NOUN O
+, PUNCT O
+the DET O
+threshold NOUN O
+for ADP O
+vitamin NOUN O
+D NOUN O
+deficiency NOUN O
+. PUNCT O
+
+An DET O
+anti ADJ O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I NOUN B-AC
+antibody NOUN O
+[ X O
+18 NUM O
+] PUNCT O
+yielded VERB O
+specific ADJ O
+staining NOUN O
+in ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+dorsal ADJ B-LF
+root NOUN I-LF
+ganglia NOUN I-LF
+( PUNCT O
+DRG PROPN B-AC
+) PUNCT O
+, PUNCT O
+but CCONJ O
+not PART O
+in ADP O
+those PRON O
+from ADP O
+global ADJ O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− SYM O
+mice NOUN O
+[ X O
+19 NUM O
+] PUNCT O
+, PUNCT O
+thereby ADV O
+revealing VERB O
+Cre NOUN O
+/ SYM O
+loxP NOUN O
+- PUNCT O
+mediated VERB O
+deletion NOUN O
+of ADP O
+PKG PROPN B-AC
+- PUNCT B-AC
+I NOUN B-AC
+in ADP O
+DRG PROPN B-AC
+of ADP O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− SYM O
+mice NOUN O
+( PUNCT O
+Figure NOUN O
+1A NUM O
+) PUNCT O
+. PUNCT O
+Quantitative ADJ O
+size NOUN O
+- PUNCT O
+frequency NOUN O
+analysis NOUN O
+revealed VERB O
+that SCONJ O
+a DET O
+majority NOUN O
+of ADP O
+DRG PROPN B-AC
+neurons NOUN O
+expressing VERB O
+PKG PROPN B-AC
+- PUNCT B-AC
+I NOUN B-AC
+in ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+mice NOUN O
+are AUX O
+small ADJ O
+- PUNCT O
+diameter NOUN O
+neurons NOUN O
+, PUNCT O
+which PRON O
+show VERB O
+a DET O
+near ADV O
+complete ADJ O
+loss NOUN O
+of ADP O
+PKG PROPN B-AC
+- PUNCT B-AC
+I NOUN B-AC
+expression NOUN O
+in ADP O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− SYM O
+mice NOUN O
+( PUNCT O
+Figure NOUN O
+1B NUM O
+; PUNCT O
+p<0.001 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+first ADJ O
+- PUNCT O
+stage NOUN O
+sampling NOUN O
+frame NOUN O
+consists VERB O
+of ADP O
+a DET O
+list NOUN O
+of ADP O
+primary ADJ B-LF
+sampling NOUN I-LF
+units NOUN I-LF
+( PUNCT O
+PSUs PROPN B-AC
+) PUNCT O
+or CCONJ O
+enumeration NOUN O
+areas NOUN O
+( PUNCT O
+EAs NOUN B-AC
+) PUNCT O
+that PRON O
+covered VERB O
+the DET O
+entire ADJ O
+country NOUN O
+and CCONJ O
+usually ADV O
+were AUX O
+obtained VERB O
+from ADP O
+the DET O
+latest ADJ O
+national ADJ O
+census NOUN O
+— PUNCT O
+when SCONJ O
+available ADJ O
+. PUNCT O
+
+Furthermore ADV O
+, PUNCT O
+galectin NOUN B-LF
+( PUNCT O
+Gal)-9 NUM B-AC
+was AUX O
+found VERB O
+elevated ADJ O
+in ADP O
+AH PROPN B-AC
+[ X O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+Moreover ADV O
+, PUNCT O
+the DET O
+minor ADJ B-LF
+allele NOUN I-LF
+frequency NOUN I-LF
+( PUNCT O
+MAF NOUN B-AC
+) PUNCT O
+of ADP O
+the DET O
+SNPs NOUN B-AC
+detected VERB O
+by ADP O
+NGS PROPN O
+was AUX O
+extracted VERB O
+from ADP O
+Single PROPN B-LF
+Nucleotide PROPN I-LF
+Polymorphism PROPN I-LF
+Database PROPN I-LF
+( PUNCT O
+dbSNP PROPN B-AC
+) PUNCT O
+and/or CCONJ O
+The DET B-LF
+Exome PROPN I-LF
+Aggregation PROPN I-LF
+Consortium PROPN I-LF
+( PUNCT O
+ExAC PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+NPV NOUN B-AC
+= PUNCT O
+negative ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+. PUNCT O
+
+GSH PROPN B-AC
+depletion NOUN O
+obtained VERB O
+by ADP O
+buthionine NOUN B-LF
+sulfoximine NOUN I-LF
+( PUNCT O
+BSO PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+irreversible ADJ O
+inhibitor NOUN O
+of ADP O
+rGCS PROPN B-AC
+, PUNCT O
+is AUX O
+the DET O
+most ADV O
+frequently ADV O
+used VERB O
+. PUNCT O
+
+Our PRON O
+study NOUN O
+complied VERB O
+with ADP O
+the DET O
+Declaration PROPN O
+of ADP O
+Helsinki PROPN O
+adopted VERB O
+by ADP O
+the DET O
+World PROPN B-LF
+Medical PROPN I-LF
+Association PROPN I-LF
+( PUNCT O
+WMA PROPN B-AC
+) PUNCT O
+in ADP O
+1964 NUM O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+CCR PROPN B-AC
+, PUNCT O
+case NOUN B-LF
+- ADJ I-LF
+carrier NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+IPD PROPN B-AC
+, PUNCT O
+invasive ADJ B-LF
+pneumococcal NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+NVT PROPN B-AC
+, PUNCT O
+non ADJ O
+- ADJ O
+vaccine ADJ O
+serotype NOUN O
+group NOUN O
+( PUNCT O
+non ADJ O
+- ADJ O
+PCV13 ADJ B-AC
+serotypes NOUN O
+and CCONJ O
+serotype NOUN O
+3 NUM O
+) PUNCT O
+; PUNCT O
+UI NOUN B-AC
+, PUNCT O
+uncertainty NOUN B-LF
+interval NOUN I-LF
+. PUNCT O
+
+Third ADJ O
+- PUNCT O
+order NOUN O
+femoral ADJ O
+arteries NOUN O
+( PUNCT O
+internal ADJ O
+diameter NOUN O
+< ADP O
+300μm NUM O
+) PUNCT O
+were AUX O
+isolated VERB O
+and CCONJ O
+placed VERB O
+in ADP O
+physiologic ADJ B-LF
+buffer NOUN I-LF
+solution NOUN I-LF
+( PUNCT O
+PBS PROPN B-AC
+) PUNCT O
+. PUNCT O
+A DET O
+segment NOUN O
+of ADP O
+approximately ADV O
+2 NUM O
+mm NOUN O
+in ADP O
+length NOUN O
+was AUX O
+cut VERB O
+and CCONJ O
+threaded VERB O
+with ADP O
+two NUM O
+40 NUM O
+- PUNCT O
+μm NOUN O
+diameter NOUN O
+stainless ADJ O
+steel NOUN O
+wires NOUN O
+. PUNCT O
+
+For ADP O
+the DET O
+entire ADJ O
+study NOUN O
+population NOUN O
+( PUNCT O
+ages NOUN O
+0–64 NUM O
+) PUNCT O
+, PUNCT O
+rate NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+RRs NOUN B-AC
+) PUNCT O
+were AUX O
+calculated VERB O
+by ADP O
+counting VERB O
+occurrences NOUN O
+of ADP O
+the DET O
+outcomes NOUN O
+of ADP O
+interest NOUN O
+during ADP O
+the DET O
+5 NUM O
+- PUNCT O
+day NOUN O
+county NOUN O
+- PUNCT O
+wide ADJ O
+exposed VERB O
+periods NOUN O
+P1 NOUN O
+( PUNCT O
+October PROPN O
+22–26 NUM O
+; PUNCT O
+highest ADJ O
+exposures NOUN O
+) PUNCT O
+, PUNCT O
+P2 PROPN O
+( PUNCT O
+October PROPN O
+27–31 NUM O
+; PUNCT O
+lower ADJ O
+exposures NOUN O
+and CCONJ O
+lagged ADJ O
+or CCONJ O
+cumulative ADJ O
+effects NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+P3 PROPN O
+( PUNCT O
+November PROPN O
+1–5 NUM O
+; PUNCT O
+lagged ADJ O
+effects NOUN O
+and CCONJ O
+cumulative ADJ O
+effects NOUN O
+) PUNCT O
+and CCONJ O
+comparing VERB O
+them PRON O
+with ADP O
+occurrences NOUN O
+of ADP O
+the DET O
+same ADJ O
+outcome NOUN O
+during ADP O
+six NUM O
+5 NUM O
+- PUNCT O
+day NOUN O
+comparison NOUN O
+periods NOUN O
+, PUNCT O
+matched VERB O
+on ADP O
+day NOUN O
+of ADP O
+week NOUN O
+( PUNCT O
+5 NUM O
+- PUNCT O
+day NOUN O
+periods NOUN O
+starting VERB O
+3 NUM O
+, PUNCT O
+4 NUM O
+, PUNCT O
+5 NUM O
+, PUNCT O
+6 NUM O
+, PUNCT O
+8 NUM O
+, PUNCT O
+and CCONJ O
+9 NUM O
+weeks NOUN O
+before ADP O
+each DET O
+exposed VERB O
+period NOUN O
+; PUNCT O
+weeks NOUN O
+1 NUM O
+and CCONJ O
+2 NUM O
+were AUX O
+excluded VERB O
+because SCONJ O
+, PUNCT O
+for ADP O
+P2 PROPN O
+and CCONJ O
+P3 PROPN O
+, PUNCT O
+they PRON O
+would AUX O
+have AUX O
+overlapped VERB O
+with ADP O
+P1 NOUN O
+, PUNCT O
+and CCONJ O
+week NOUN O
+7 NUM O
+was AUX O
+excluded VERB O
+to ADP O
+prevent VERB O
+comparing VERB O
+P1 NOUN O
+to ADP O
+the DET O
+Labor PROPN O
+Day PROPN O
+holiday NOUN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+three NUM O
+combinations NOUN O
+— PUNCT O
+amodiaquine NOUN B-LF
+( PUNCT O
+AQ NOUN B-AC
+) PUNCT O
+and CCONJ O
+sulfadoxine NOUN B-LF
+- PUNCT I-LF
+pyrimethamine NOUN I-LF
+( PUNCT O
+SP PROPN B-AC
+) PUNCT O
+; PUNCT O
+AQ NOUN B-AC
+and CCONJ O
+artesunate NOUN B-LF
+( PUNCT O
+AS PROPN B-AC
+) PUNCT O
+; PUNCT O
+and CCONJ O
+artemether NOUN B-LF
+- PUNCT I-LF
+lumefantrine NOUN I-LF
+( PUNCT O
+AL)—were PROPN B-AC
+used VERB O
+to PART O
+treat VERB O
+Tanzanian ADJ O
+children NOUN O
+. PUNCT O
+
+The DET O
+aim NOUN O
+of ADP O
+the DET O
+present ADJ O
+study NOUN O
+was AUX O
+to PART O
+assess VERB O
+if SCONJ O
+the DET O
+last ADJ O
+two NUM O
+doses NOUN O
+of ADP O
+AQ PROPN B-AC
+were AUX O
+truly ADV O
+administered VERB O
+as SCONJ O
+prescribed VERB O
+by ADP O
+the DET O
+parents NOUN O
+at ADP O
+home NOUN O
+based VERB O
+on ADP O
+drug NOUN O
+level NOUN O
+measurement NOUN O
+and CCONJ O
+PK NOUN B-LF
+modelling NOUN O
+, PUNCT O
+which PRON O
+is AUX O
+a DET O
+good ADJ O
+proxy NOUN O
+of ADP O
+medication NOUN O
+adherence NOUN O
+and CCONJ O
+an DET O
+assessment NOUN O
+of ADP O
+the DET O
+feasibility NOUN O
+of ADP O
+self NOUN O
+- PUNCT O
+administred VERB O
+malaria NOUN O
+preventive ADJ O
+treatments NOUN O
+. PUNCT O
+
+In ADP O
+all DET O
+vertebrates NOUN O
+, PUNCT O
+the DET O
+MLR PROPN B-AC
+acts VERB O
+as ADP O
+a DET O
+motor NOUN O
+command NOUN O
+center NOUN O
+that PRON O
+controls VERB O
+locomotion NOUN O
+via ADP O
+descending VERB O
+projections NOUN O
+to ADP O
+brainstem NOUN O
+reticulospinal ADJ B-LF
+( PUNCT O
+RS PROPN B-AC
+) PUNCT O
+neurons NOUN O
+[ PUNCT O
+14–22 NUM O
+] PUNCT O
+. PUNCT O
+
+Estimates NOUN O
+were AUX O
+reported VERB O
+in ADP O
+adjusted ADJ O
+odds NOUN O
+ratios NOUN O
+with ADP O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+and CCONJ O
+a DET O
+significant ADJ O
+association NOUN O
+was AUX O
+declared VERB O
+at ADP O
+p NOUN O
+- PUNCT O
+value NOUN O
+of ADP O
+less ADJ O
+than ADP O
+0.05 NUM O
+. PUNCT O
+
+Engagement NOUN O
+of ADP O
+PRRs NOUN B-AC
+such ADJ O
+as ADP O
+Toll PROPN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptors NOUN I-LF
+( PUNCT O
+TLRs NOUN B-AC
+) PUNCT O
+and CCONJ O
+C NOUN B-LF
+- PUNCT I-LF
+type NOUN I-LF
+lectin NOUN I-LF
+receptors NOUN I-LF
+( PUNCT O
+CLRs NOUN B-AC
+) PUNCT O
+leads VERB O
+to ADP O
+DC PROPN B-AC
+activation NOUN O
+, PUNCT O
+characterized VERB O
+with ADP O
+up ADV O
+- PUNCT O
+regulated VERB O
+capacities NOUN O
+in ADP O
+antigen NOUN O
+presentation NOUN O
+, PUNCT O
+migration NOUN O
+, PUNCT O
+and CCONJ O
+cytokine NOUN O
+production NOUN O
+. PUNCT O
+
+Although SCONJ O
+we PRON O
+do AUX O
+frequently ADV O
+observe VERB O
+H3K4me3 NOUN O
+occupancy NOUN O
+at ADP O
+transcription NOUN B-LF
+start NOUN I-LF
+sites NOUN I-LF
+( PUNCT O
+TSSs PROPN B-AC
+) PUNCT O
+flanking VERB O
+PH NOUN O
+sites NOUN O
+, PUNCT O
+this PRON O
+is AUX O
+almost ADV O
+exclusively ADV O
+observed VERB O
+at ADP O
+the DET O
+boundary NOUN O
+of ADP O
+large ADJ O
+H3K27me3 NOUN O
+domains NOUN O
+( PUNCT O
+see VERB O
+Text NOUN O
+S1 NOUN O
+) PUNCT O
+. PUNCT O
+
+OSCN- PROPN O
+, PUNCT O
+hypothiocyanite NOUN O
+; PUNCT O
+OI- PROPN O
+, PUNCT O
+hypoiodite NOUN O
+; PUNCT O
+IAV PROPN B-AC
+, PUNCT O
+influenza NOUN B-LF
+A NOUN I-LF
+virus NOUN I-LF
+; PUNCT O
+IBV PROPN B-AC
+, PUNCT O
+influenza NOUN B-LF
+B NOUN I-LF
+virus NOUN I-LF
+. PUNCT O
+
+The DET O
+Drosophila PROPN O
+protein NOUN O
+Cortex PROPN O
+( PUNCT O
+Cort PROPN O
+) PUNCT O
+is AUX O
+a DET O
+female ADJ O
+, PUNCT O
+meiosis NOUN O
+- PUNCT O
+specific ADJ O
+activator NOUN O
+of ADP O
+the DET O
+Anaphase PROPN B-LF
+Promoting VERB I-LF
+Complex PROPN I-LF
+/ SYM I-LF
+Cyclosome PROPN I-LF
+( PUNCT O
+APC PROPN B-AC
+/ SYM B-AC
+C PROPN B-AC
+) PUNCT O
+, PUNCT O
+an DET O
+E3 PROPN O
+ubiquitin NOUN O
+ligase NOUN O
+. PUNCT O
+
+The DET O
+aims NOUN O
+of ADP O
+the DET O
+Prenatal PROPN B-LF
+Repeat PROPN I-LF
+Corticosteroid PROPN I-LF
+International PROPN I-LF
+IPD PROPN I-LF
+- PUNCT I-LF
+MA PROPN I-LF
+Study PROPN I-LF
+: PUNCT I-LF
+assessing VERB I-LF
+the DET I-LF
+effects NOUN I-LF
+using VERB I-LF
+the DET I-LF
+best ADJ I-LF
+level NOUN I-LF
+of ADP I-LF
+Evidence PROPN I-LF
+( PUNCT O
+PRECISE PROPN B-AC
+) PUNCT O
+individual ADJ B-LF
+participant NOUN I-LF
+data NOUN I-LF
+meta NOUN B-LF
+- PUNCT I-LF
+analysis NOUN I-LF
+( PUNCT O
+IPD PROPN B-AC
+- PUNCT O
+MA PROPN B-AC
+) PUNCT O
+were AUX O
+to ADP O
+assess VERB O
+the DET O
+effect NOUN O
+of ADP O
+repeat NOUN O
+prenatal ADJ O
+corticosteroids NOUN O
+when SCONJ O
+given VERB O
+to ADP O
+women NOUN O
+at ADP O
+high ADJ O
+, PUNCT O
+ongoing ADJ O
+risk NOUN O
+of ADP O
+preterm ADJ O
+birth NOUN O
+on ADP O
+important ADJ O
+clinical ADJ O
+outcomes NOUN O
+and CCONJ O
+whether SCONJ O
+treatment NOUN O
+effects NOUN O
+varied VERB O
+depending VERB O
+on ADP O
+participant NOUN O
+and CCONJ O
+treatment NOUN O
+factors NOUN O
+. PUNCT O
+
+PMI PROPN B-AC
+, PUNCT O
+prioritized VERB B-LF
+memory NOUN I-LF
+item NOUN I-LF
+. PUNCT O
+
+In ADP O
+2012 NUM O
+, PUNCT O
+the DET O
+Ministry PROPN B-LF
+of ADP I-LF
+Health PROPN I-LF
+( PUNCT O
+MOH PROPN B-AC
+) PUNCT O
+in ADP O
+Zambia PROPN O
+started VERB O
+a DET O
+national ADJ O
+multi ADJ O
+- ADJ O
+disciplinary ADJ O
+mentorship NOUN O
+program NOUN O
+. PUNCT O
+
+Ten NUM O
+communities NOUN O
+included VERB O
+algae NOUN O
+only ADV O
+( PUNCT O
+A NOUN O
+) PUNCT O
+, PUNCT O
+10 NUM O
+comprised VERB O
+algae NOUN O
++ CCONJ O
+grazers NOUN O
+( PUNCT O
+AG NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+10 NUM O
+included VERB O
+algae NOUN O
++ CCONJ O
+grazers NOUN O
++ CCONJ O
+predators NOUN O
+( PUNCT O
+AGP NOUN B-AC
+) PUNCT O
+. PUNCT O
+We PRON O
+sampled VERB O
+net ADJ O
+ecosystem NOUN O
+oxygen NOUN O
+production NOUN O
+( PUNCT O
+NEP PROPN B-AC
+) PUNCT O
+, PUNCT O
+ecosystem NOUN B-LF
+respiration NOUN I-LF
+( PUNCT O
+ER NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+total ADJ O
+phytoplankton NOUN O
+biomass NOUN O
+( PUNCT O
+MB NOUN O
+) PUNCT O
+weekly ADV O
+for ADP O
+8 NUM O
+weeks NOUN O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+ID NOUN B-AC
+, PUNCT O
+intellectual ADJ B-LF
+disability NOUN I-LF
+; PUNCT O
+HT PROPN O
+, PUNCT O
+hypothyroidism NOUN O
+; PUNCT O
+NHT NOUN O
+, PUNCT O
+no DET O
+hypothyroidism NOUN O
+; PUNCT O
+INC PROPN O
+, PUNCT O
+household NOUN O
+income NOUN O
+. PUNCT O
+
+The DET O
+other ADJ O
+two NUM O
+studies NOUN O
+determined VERB O
+that SCONJ O
+NRF2 PROPN B-AC
+was AUX O
+a DET O
+good ADJ O
+biomarker NOUN O
+for ADP O
+predicting VERB O
+response NOUN O
+to ADP O
+EGFR PROPN B-AC
+- PUNCT B-AC
+TKI PROPN B-AC
+( PUNCT O
+Epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+tyrosine NOUN I-LF
+kinase NOUN I-LF
+inhibitor NOUN I-LF
+) PUNCT O
+in ADP O
+patients NOUN O
+with ADP O
+EGFR PROPN O
+gene NOUN O
+mutations NOUN O
+. PUNCT O
+
+In ADP O
+an DET O
+attempt NOUN O
+to PART O
+control VERB O
+an DET O
+epidemic NOUN O
+of ADP O
+ovine ADJ B-LF
+Johne PROPN I-LF
+’s PART I-LF
+disease NOUN I-LF
+( PUNCT O
+OJD PROPN B-AC
+) PUNCT O
+in ADP O
+New PROPN B-LF
+South PROPN I-LF
+Wales PROPN I-LF
+( PUNCT O
+NSW PROPN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+government NOUN O
+/ SYM O
+industry NOUN O
+sponsored VERB O
+voluntary ADJ O
+vaccination NOUN O
+/ SYM O
+on ADP O
+- PUNCT O
+farm NOUN O
+management NOUN O
+program NOUN O
+commenced VERB O
+in ADP O
+2000 NUM O
+. PUNCT O
+
+In ADP O
+humans NOUN O
+, PUNCT O
+contrary ADJ O
+to ADP O
+natural ADJ B-LF
+killer NOUN I-LF
+T PROPN I-LF
+( PUNCT O
+NKT PROPN B-AC
+) PUNCT O
+cells NOUN O
+, PUNCT O
+MAIT PROPN B-AC
+cells NOUN O
+display VERB O
+a DET O
+naïve ADJ O
+phenotype NOUN O
+in ADP O
+the DET O
+thymus NOUN O
+as ADP O
+well ADV O
+as ADP O
+in ADP O
+cord NOUN O
+blood NOUN O
+where SCONJ O
+they PRON O
+are AUX O
+in ADP O
+low ADJ O
+numbers NOUN O
+. PUNCT O
+
+PM2.5 NOUN B-AC
+, PUNCT O
+fine ADJ B-LF
+particulate NOUN I-LF
+matter NOUN I-LF
+( PUNCT O
+particulate NOUN O
+matter NOUN O
+with ADP O
+a DET O
+diameter NOUN O
+of ADP O
+< ADP O
+2.5 NUM O
+μm NOUN O
+) PUNCT O
+; PUNCT O
+SD NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+
+Intra ADJ B-LF
+- ADJ I-LF
+cluster NOUN I-LF
+correlation NOUN I-LF
+coefficients NOUN I-LF
+( PUNCT O
+ICCs NOUN B-AC
+) PUNCT O
+were AUX O
+calculated VERB O
+for ADP O
+each DET O
+outcome NOUN O
+. PUNCT O
+
+ICU PROPN B-AC
+, PUNCT O
+Intensive PROPN B-LF
+Care PROPN I-LF
+Unit PROPN I-LF
+; PUNCT O
+IMCU PROPN B-AC
+, PUNCT O
+Intermediate PROPN B-LF
+Care PROPN I-LF
+Unit PROPN I-LF
+; PUNCT O
+LSC PROPN B-AC
+, PUNCT O
+Life PROPN B-LF
+Supporting PROPN I-LF
+Care PROPN I-LF
+; PUNCT O
+LSC PROPN B-AC
+- PUNCT B-AC
+L PROPN B-AC
+, PUNCT O
+Life PROPN B-LF
+Supporting PROPN I-LF
+Care PROPN I-LF
+Limitation PROPN I-LF
+; PUNCT O
+SAPS PROPN B-AC
+II NUM B-AC
+, PUNCT O
+Simplified PROPN B-LF
+Acute PROPN I-LF
+Physiology PROPN I-LF
+Score PROPN I-LF
+; PUNCT O
+SOFA PROPN B-AC
+, PUNCT O
+Sequential PROPN B-LF
+Organ PROPN I-LF
+failure PROPN I-LF
+Assessment PROPN I-LF
+; PUNCT O
+LOS PROPN B-AC
+, PUNCT O
+Length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+. PUNCT O
+
+OCT-4 PROPN O
+, PUNCT O
+octamer NOUN O
+- PUNCT O
+binding VERB O
+transcription NOUN O
+factor-4 NOUN O
+; PUNCT O
+Sox-2 PROPN B-AC
+, PUNCT O
+SRY PROPN B-LF
+( PUNCT I-LF
+sex NOUN I-LF
+determining VERB I-LF
+region NOUN I-LF
+Y)-box NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+Nanog PROPN B-AC
+, PUNCT O
+Nanog PROPN B-LF
+homeobox NOUN I-LF
+; PUNCT O
+TRA-1 PROPN B-AC
+- PUNCT B-AC
+60 NUM B-AC
+, PUNCT O
+podocalyxin NOUN B-LF
+; PUNCT O
+ZO-1 PROPN B-AC
+, PUNCT O
+zonula NOUN O
+occludens NOUN O
+1 NUM O
+; PUNCT O
+RPE65 PROPN B-AC
+, PUNCT O
+Retinal ADJ O
+pigment NOUN O
+epithelium NOUN O
+- PUNCT O
+specific ADJ O
+65 NUM O
+kDa NOUN O
+protein NOUN O
+; PUNCT O
+Na PROPN O
++ SYM O
+/K SYM O
++ SYM O
+ATPase PROPN O
+, PUNCT O
+sodium NOUN O
+- PUNCT O
+potassium NOUN O
+adenosine NOUN O
+triphosphatase NOUN O
+; PUNCT O
+RPE PROPN B-AC
+cell NOUN O
+, PUNCT O
+retinal ADJ O
+pigment NOUN O
+epithelial ADJ O
+cell NOUN O
+
+ω NOUN B-LF
+- NOUN I-LF
+conotoxin NOUN I-LF
+MVIIC PROPN I-LF
+
+Black ADJ O
+dots NOUN O
+indicate VERB O
+that SCONJ O
+the DET O
+estimate NOUN O
+had VERB O
+a DET O
+p NOUN O
+- PUNCT O
+value NOUN O
+< ADP O
+0.05 NUM O
+; PUNCT O
+white ADJ O
+dots NOUN O
+indicate VERB O
+a DET O
+p NOUN O
+- PUNCT O
+value NOUN O
+≥ ADP O
+0.05 NUM O
+. PUNCT O
+8 NUM O
+- PUNCT O
+OHDG PROPN O
+: PUNCT O
+8 NUM O
+- PUNCT O
+hydroxy-2′-deoxyguanosine NOUN O
+; PUNCT O
+B PROPN O
+, PUNCT O
+baseline NOUN O
+; PUNCT O
+BPA PROPN B-AC
+, PUNCT O
+bisphenol NOUN B-LF
+A NOUN I-LF
+; PUNCT O
+DEHP PROPN B-AC
+, PUNCT O
+di(2 NOUN B-LF
+- PUNCT I-LF
+ethylhexyl NOUN I-LF
+) PUNCT I-LF
+phthalate NOUN I-LF
+; PUNCT O
+DOP PROPN B-AC
+, PUNCT O
+di NOUN B-LF
+- PUNCT I-LF
+n NOUN I-LF
+- PUNCT I-LF
+octyl NOUN I-LF
+phthalate NOUN I-LF
+; PUNCT O
+HMW PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+molecular ADJ I-LF
+weight NOUN I-LF
+phthalates NOUN O
+; PUNCT O
+LMW PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+molecular ADJ I-LF
+weight NOUN I-LF
+phthalates NOUN O
+; PUNCT O
+PA PROPN B-AC
+, PUNCT O
+phthalic ADJ B-LF
+acid NOUN I-LF
+; PUNCT O
+Y[number NOUN O
+] PUNCT O
+, PUNCT O
+year NOUN O
+[ X O
+number NOUN O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+also ADV O
+analyzed VERB O
+how SCONJ O
+obesity NOUN O
+related VERB O
+to ADP O
+LFAT NOUN B-AC
+measured VERB O
+by ADP O
+1H NOUN B-AC
+- PUNCT B-AC
+MRS NOUN B-AC
+in ADP O
+79 NUM O
+Finns PROPN O
+and CCONJ O
+118 NUM O
+Chinese PROPN O
+with ADP O
+type NOUN B-LF
+2 NUM I-LF
+diabetes NOUN I-LF
+( PUNCT O
+T2D NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+Hb NOUN B-AC
+, PUNCT O
+haemoglobin NOUN B-LF
+concentration NOUN I-LF
+; PUNCT O
+LAM PROPN B-AC
+, PUNCT O
+lipoarabinomannan NOUN B-LF
+assay NOUN I-LF
+; PUNCT O
+MTB NOUN B-AC
+, PUNCT O
+Mycobacterium NOUN B-LF
+tuberculosis NOUN I-LF
+; PUNCT O
+TB PROPN B-AC
+, PUNCT O
+tuberculosis NOUN B-LF
+. PUNCT O
+
+Table NOUN O
+2 NUM O
+shows VERB O
+the DET O
+identified VERB O
+loci NOUN O
+with ADP O
+a DET O
+logarithm NOUN B-LF
+of ADP I-LF
+the DET I-LF
+odds NOUN I-LF
+( PUNCT O
+LOD PROPN B-AC
+) PUNCT O
+score NOUN O
+> SYM O
+2 NUM O
+in ADP O
+the DET O
+total ADJ O
+cohort NOUN O
+, PUNCT O
+and CCONJ O
+in ADP O
+sex NOUN O
+/ SYM O
+twin NOUN O
+specific ADJ O
+analyses NOUN O
+. PUNCT O
+
+Substrate NOUN O
+glycerol NOUN O
+and CCONJ O
+the DET O
+products NOUN O
+PDO NOUN B-AC
+, PUNCT O
+butyric ADJ O
+acid NOUN O
+, PUNCT O
+acetic ADJ O
+acid NOUN O
+, PUNCT O
+lactic ADJ O
+acid NOUN O
+, PUNCT O
+and CCONJ O
+butanol NOUN O
+were AUX O
+quantified VERB O
+using VERB O
+ultra ADJ B-LF
+- ADJ I-LF
+fast ADJ I-LF
+liquid NOUN I-LF
+chromatography NOUN I-LF
+( PUNCT O
+UFLC PROPN B-AC
+) PUNCT O
+with ADP O
+a DET O
+refractive ADJ O
+index NOUN O
+detector NOUN O
+( PUNCT O
+Shimadzu PROPN O
+RID PROPN O
+10A PROPN O
+) PUNCT O
+at ADP O
+60 NUM O
+° NOUN O
+C NOUN O
+and CCONJ O
+AMINEX PROPN O
+HPX PROPN O
+— PUNCT O
+87H NUM O
+column NOUN O
+( PUNCT O
+Biorad PROPN O
+) PUNCT O
+at ADP O
+63 NUM O
+° NOUN O
+C NOUN O
+, PUNCT O
+a DET O
+solution NOUN O
+of ADP O
+3 NUM O
+mM NOUN O
+of ADP O
+sulfuric ADJ O
+acid NOUN O
+as ADP O
+the DET O
+phase NOUN O
+mobile NOUN O
+, PUNCT O
+and CCONJ O
+0.5 NUM O
+mL NOUN O
+/ SYM O
+min NOUN O
+flow NOUN O
+during ADP O
+45 NUM O
+minutes NOUN O
+of ADP O
+run NOUN O
+time NOUN O
+. PUNCT O
+
+This DET O
+palmitoylation NOUN O
+site NOUN O
+is AUX O
+located VERB O
+within ADP O
+the DET O
+isoform NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+targeting NOUN I-LF
+and CCONJ I-LF
+interaction NOUN I-LF
+domain NOUN I-LF
+( PUNCT O
+ISTID PROPN B-AC
+) PUNCT O
+of ADP O
+Nmnat2 PROPN O
+. PUNCT O
+
+Therefore ADV O
+, PUNCT O
+the DET O
+findings NOUN O
+of ADP O
+the DET O
+previous ADJ O
+study NOUN O
+[ PUNCT O
+31 NUM O
+] PUNCT O
+do AUX O
+not PART O
+allow VERB O
+the DET O
+general ADJ O
+conclusion NOUN O
+that PRON O
+M1 PROPN B-AC
+plasticity NOUN O
+is AUX O
+normal ADJ O
+in ADP O
+ET PROPN B-AC
+. PUNCT O
+Another DET O
+study NOUN O
+that PRON O
+applied VERB O
+continuous ADJ O
+theta NOUN O
+- PUNCT O
+burst NOUN O
+stimulation NOUN O
+, PUNCT O
+a DET O
+protocol NOUN O
+that PRON O
+in ADP O
+healthy ADJ O
+subjects NOUN O
+leads VERB O
+to ADP O
+a DET O
+long ADJ B-LF
+- PUNCT I-LF
+term NOUN I-LF
+depression NOUN I-LF
+( PUNCT O
+LTD)-like PROPN B-AC
+decrease NOUN O
+in ADP O
+MEP PROPN B-AC
+amplitude NOUN O
+[ PUNCT O
+34 NUM O
+] PUNCT O
+, PUNCT O
+demonstrated VERB O
+a DET O
+lack NOUN O
+of ADP O
+this DET O
+type NOUN O
+of ADP O
+LTD NOUN B-AC
+- PUNCT O
+like ADJ O
+plasticity NOUN O
+in ADP O
+ET PROPN B-AC
+patients NOUN O
+[ PUNCT O
+35 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+identify VERB O
+the DET O
+transcription NOUN O
+factor NOUN O
+Promyelocytic PROPN B-LF
+Leukemia PROPN I-LF
+Zinc PROPN I-LF
+Finger PROPN I-LF
+( PUNCT O
+PLZF PROPN B-AC
+) PUNCT O
+as ADP O
+a DET O
+critical ADJ O
+regulator NOUN O
+of ADP O
+this DET O
+process NOUN O
+in ADP O
+the DET O
+chick NOUN O
+spinal NOUN O
+cord NOUN O
+. PUNCT O
+
+CD NOUN B-AC
+, PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+; PUNCT O
+CSC PROPN B-AC
+, PUNCT O
+cancer NOUN B-LF
+stem NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+GD2 PROPN B-AC
+: PUNCT O
+disialoganglioside NOUN B-LF
+; PUNCT O
+NB PROPN B-AC
+, PUNCT O
+neuroblastoma NOUN B-LF
+; PUNCT O
+NK PROPN B-AC
+, PUNCT O
+natural ADJ B-LF
+killer NOUN I-LF
+; PUNCT O
+pDC NOUN B-AC
+, PUNCT O
+plasmacytoid NOUN B-LF
+dendritic ADJ I-LF
+cell NOUN I-LF
+; PUNCT O
+TLR PROPN B-AC
+, PUNCT O
+toll NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptor NOUN I-LF
+. PUNCT O
+
+Focusing VERB O
+on ADP O
+the DET O
+endometrium NOUN O
+during ADP O
+the DET O
+implantation NOUN O
+phase NOUN O
+, PUNCT O
+the DET O
+mesenchymal NOUN B-LF
+- PUNCT I-LF
+epithelial NOUN I-LF
+transition NOUN I-LF
+( PUNCT O
+MET PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+the DET O
+reverse ADJ O
+process NOUN O
+to ADP O
+the DET O
+EMT NOUN B-AC
+, PUNCT O
+is AUX O
+induced VERB O
+in ADP O
+the DET O
+endometrium NOUN O
+and CCONJ O
+promotes VERB O
+the DET O
+acceptance NOUN O
+of ADP O
+embryos NOUN O
+to ADP O
+the DET O
+uterus NOUN O
+[ PUNCT O
+20 NUM O
+, PUNCT O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+examined VERB O
+all DET B-LF
+- ADJ I-LF
+cause NOUN I-LF
+mortality NOUN I-LF
+( PUNCT O
+ACM PROPN B-AC
+) PUNCT O
+, PUNCT O
+drug NOUN B-LF
+- ADJ I-LF
+related VERB I-LF
+poisoning NOUN I-LF
+( PUNCT O
+DRP NOUN B-AC
+) PUNCT O
+mortality NOUN O
+, PUNCT O
+and CCONJ O
+mortality NOUN O
+not PART O
+attributable ADJ O
+to ADP O
+DRP NOUN B-AC
+( PUNCT O
+non ADJ O
+- ADJ O
+DRP NOUN B-AC
+) PUNCT O
+. PUNCT O
+Models NOUN O
+included VERB O
+potential ADJ O
+confounding VERB O
+factors NOUN O
+. PUNCT O
+
+This PRON O
+was AUX O
+a DET O
+cross ADJ O
+- PUNCT O
+sectional ADJ O
+study NOUN O
+which PRON O
+used VERB O
+data NOUN O
+from ADP O
+the DET O
+2015 NUM O
+Mozambique PROPN O
+Global PROPN B-LF
+School PROPN I-LF
+- PUNCT I-LF
+based VERB I-LF
+Health PROPN I-LF
+Survey PROPN I-LF
+( PUNCT O
+GSHS PROPN B-AC
+) PUNCT O
+collected VERB O
+using VERB O
+a DET O
+clustered VERB O
+sample NOUN O
+design NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+AA PROPN B-AC
+, PUNCT O
+artesunate NOUN B-LF
+- PUNCT I-LF
+amodiaquine NOUN I-LF
+; PUNCT O
+AL PROPN B-AC
+, PUNCT O
+artemether NOUN B-LF
+- PUNCT I-LF
+lumefantrine NOUN I-LF
+; PUNCT O
+AM PROPN B-AC
+, PUNCT O
+artesunate NOUN B-LF
+- PUNCT I-LF
+mefloquine NOUN I-LF
+; PUNCT O
+DP PROPN B-AC
+, PUNCT O
+dihydroartemisinin NOUN B-LF
+- PUNCT I-LF
+piperaquine NOUN I-LF
+; PUNCT O
+Hb NOUN B-AC
+, PUNCT O
+haemoglobin NOUN B-LF
+; PUNCT O
+IQR NOUN B-AC
+, PUNCT O
+interquartile ADJ B-LF
+range NOUN I-LF
+; PUNCT O
+n NOUN O
+, PUNCT O
+number NOUN O
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+. PUNCT O
+
+This DET O
+context NOUN O
+of ADP O
+T PROPN O
+cells NOUN O
+within ADP O
+the DET O
+tumor NOUN O
+, PUNCT O
+tumor NOUN B-LF
+- PUNCT I-LF
+infiltrating VERB I-LF
+lymphocytes NOUN I-LF
+( PUNCT O
+TILs PROPN B-AC
+) PUNCT O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+immune ADJ O
+cells NOUN O
+in ADP O
+the DET O
+surrounding VERB O
+stroma NOUN O
+, PUNCT O
+which PRON O
+can AUX O
+include VERB O
+a DET O
+pathologic ADJ O
+feature NOUN O
+called VERB O
+“ PUNCT O
+Crohn’s PROPN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+Lymphoid PROPN I-LF
+Reaction PROPN I-LF
+” PUNCT O
+( PUNCT O
+CLR PROPN B-AC
+) PUNCT O
+, PUNCT O
+include VERB O
+a DET O
+mix NOUN O
+of ADP O
+T PROPN O
+cells NOUN O
+and CCONJ O
+B NOUN O
+cells NOUN O
+. PUNCT O
+
+( PUNCT O
+A X O
+, PUNCT O
+B X O
+) PUNCT O
+Fitness NOUN O
+advantage NOUN O
+of ADP O
+lys−orgS− NOUN B-AC
+over ADP O
+lys− NOUN O
+requires VERB O
+low ADJ O
+organosulfur NOUN B-LF
+and CCONJ O
+autophagy NOUN O
+. PUNCT O
+
+Data NOUN O
+are AUX O
+representative ADJ O
+of ADP O
+two NUM O
+independent ADJ O
+experiments NOUN O
+. PUNCT O
+aTreg PROPN B-AC
+, PUNCT O
+activated VERB B-LF
+Treg PROPN I-LF
+; PUNCT O
+IL PROPN B-AC
+, PUNCT O
+interleukin NOUN B-LF
+; PUNCT O
+Ki-67 NOUN B-AC
+, PUNCT O
+antigen NOUN B-LF
+identified VERB I-LF
+by ADP I-LF
+monoclonal ADJ I-LF
+antibody NOUN I-LF
+Ki PROPN I-LF
+67 NUM I-LF
+; PUNCT O
+rTreg NOUN B-AC
+, PUNCT O
+resting VERB B-LF
+Treg PROPN I-LF
+. PUNCT O
+
+CanR PROPN O
+, PUNCT O
+canavanine NOUN O
+- PUNCT O
+resistant ADJ O
+; PUNCT O
+dsDNA NOUN B-AC
+, PUNCT O
+double ADV B-LF
+- PUNCT I-LF
+stranded VERB I-LF
+DNA NOUN I-LF
+. PUNCT O
+
+The DET O
+supernatant NOUN O
+were AUX O
+obtained VERB O
+for ADP O
+total ADJ B-LF
+cholesterol NOUN I-LF
+( ADP O
+TC PROPN B-AC
+) PUNCT O
+and CCONJ O
+triglyceride NOUN B-LF
+( ADP O
+TG NOUN B-AC
+) PUNCT O
+analysis NOUN O
+( ADP O
+individually ADV O
+20~30 NUM O
+μL NOUN O
+) PUNCT O
+. PUNCT O
+Aliquots NOUN O
+of ADP O
+plasma NOUN O
+samples NOUN O
+( ADP O
+> ADP O
+25 NUM O
+μL NOUN O
+) PUNCT O
+were AUX O
+obtained VERB O
+for ADP O
+insulin NOUN O
+, PUNCT O
+leptin NOUN O
+, PUNCT O
+and CCONJ O
+adiponectin NOUN O
+. PUNCT O
+
+FPP NOUN B-AC
+, PUNCT O
+farnesyl NOUN B-LF
+pyrophosphate NOUN I-LF
+; PUNCT O
+PI PROPN B-AC
+, PUNCT O
+propidium NOUN B-LF
+iodide NOUN I-LF
+. PUNCT O
+
+Bleeding VERB B-LF
+on ADP I-LF
+probing VERB I-LF
+( PUNCT O
+BOP NOUN B-AC
+) PUNCT O
+is AUX O
+a DET O
+diagnostic ADJ O
+criterion NOUN O
+of ADP O
+gingival ADJ O
+inflammation NOUN O
+. PUNCT O
+
+Down PROPN B-LF
+syndrome PROPN I-LF
+( PUNCT O
+DS PROPN B-AC
+) PUNCT O
+is AUX O
+the DET O
+most ADV O
+common ADJ O
+genetic ADJ O
+cause NOUN O
+of ADP O
+intellectual ADJ O
+disability NOUN O
+, PUNCT O
+and CCONJ O
+arises VERB O
+from ADP O
+the DET O
+presence NOUN O
+of ADP O
+an DET O
+extra ADJ O
+copy NOUN O
+of ADP O
+human ADJ B-LF
+chromosome NOUN I-LF
+21 NUM I-LF
+( PUNCT O
+Hsa21 NOUN B-AC
+) PUNCT O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+Underlying VERB O
+data NOUN O
+are AUX O
+provided VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+( PUNCT O
+G PROPN O
+) PUNCT O
+Transverse ADJ O
+sections NOUN O
+of ADP O
+the DET O
+NT PROPN B-AC
+transfected VERB O
+at ADP O
+E2 NOUN O
+with ADP O
+ΔMaml1 PROPN B-AC
+and CCONJ O
+harvested VERB O
+at ADP O
+E3 PROPN O
+. PUNCT O
+Adjacent ADJ O
+sections NOUN O
+were AUX O
+used VERB O
+to ADP O
+visualize VERB O
+electroporation NOUN O
+efficiency NOUN O
+with ADP O
+GFP PROPN B-AC
+expression NOUN O
+and CCONJ O
+to ADP O
+reveal VERB O
+hΔMaml1 NOUN O
+expression NOUN O
+by ADP O
+in ADP O
+situ NOUN O
+hybridization NOUN O
+. PUNCT O
++ NOUN O
+indicates VERB O
+the DET O
+electroporated VERB O
+side NOUN O
+of ADP O
+the DET O
+NT PROPN B-AC
+. PUNCT O
+Scale NOUN O
+bar NOUN O
+represents VERB O
+50 NUM O
+μm NOUN O
+( PUNCT O
+A PROPN O
+– SYM O
+B PROPN O
+, PUNCT O
+D PROPN O
+, PUNCT O
+F PROPN O
+– SYM O
+G PROPN O
+) PUNCT O
+or CCONJ O
+25 NUM O
+μm NOUN O
+( PUNCT O
+C PROPN O
+, PUNCT O
+E PROPN O
+) PUNCT O
+. PUNCT O
+ΔMaml1 PROPN B-AC
+, PUNCT O
+dominant ADJ B-LF
+- PUNCT I-LF
+negative ADJ I-LF
+Mastermind PROPN I-LF
+- PUNCT I-LF
+like PROPN I-LF
+1 NUM I-LF
+; PUNCT O
+E PROPN O
+, PUNCT O
+embryonic ADJ O
+day NOUN O
+; PUNCT O
+EdU PROPN B-AC
+, PUNCT O
+5 NUM B-LF
+- PUNCT I-LF
+ethynyl-2′-deoxyuridine NOUN I-LF
+; PUNCT O
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+H2B PROPN B-AC
+- PUNCT O
+iRFP PROPN B-AC
+, PUNCT O
+Histone NOUN B-LF
+2B NUM I-LF
+fused VERB O
+to ADP O
+infrared ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+hae NOUN B-AC
+, PUNCT O
+hour NOUN B-LF
+after ADP I-LF
+electroporation NOUN I-LF
+; PUNCT O
+Hes5 PROPN B-AC
+, PUNCT O
+Hairy PROPN B-LF
+and CCONJ I-LF
+Enhancer PROPN I-LF
+of ADP I-LF
+Split PROPN I-LF
+5 NUM I-LF
+; PUNCT O
+HuCD PROPN B-AC
+, PUNCT O
+neuron NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+RNA NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+proteins NOUN I-LF
+HuC PROPN I-LF
+and CCONJ I-LF
+HuD PROPN I-LF
+; PUNCT O
+iRFP PROPN B-AC
+, PUNCT O
+infrared ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+Neurog2 PROPN B-AC
+, PUNCT O
+Neurogenin PROPN B-LF
+2 NUM I-LF
+; PUNCT O
+ns NOUN O
+, PUNCT O
+nonsignificant ADJ O
+; PUNCT O
+NT PROPN B-AC
+, PUNCT O
+neural ADJ B-LF
+tube NOUN I-LF
+; PUNCT O
+Pax6 PROPN B-AC
+, PUNCT O
+Paired ADJ B-LF
+box NOUN I-LF
+gene NOUN I-LF
+6 NUM I-LF
+; PUNCT O
+VNP PROPN B-AC
+, PUNCT O
+Venus PROPN B-LF
+- PUNCT I-LF
+NLS PROPN I-LF
+- PUNCT I-LF
+PEST PROPN I-LF
+. PUNCT O
+
+PubMed PROPN O
+was AUX O
+searched VERB O
+by ADP O
+combining VERB O
+two NUM O
+separate ADJ O
+queries NOUN O
+composed VERB O
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+medical ADJ B-LF
+subject NOUN I-LF
+heading NOUN I-LF
+( PUNCT O
+MeSH PROPN B-AC
+) PUNCT O
+and CCONJ O
+text NOUN B-LF
+word NOUN I-LF
+( PUNCT O
+tw NOUN B-AC
+) PUNCT O
+keywords NOUN O
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+the DET O
+exposure NOUN O
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+outcome NOUN O
+of ADP O
+interest NOUN O
+. PUNCT O
+
+The DET O
+number NOUN O
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+and CCONJ O
+IADL PROPN B-AC
+dependencies NOUN O
+were AUX O
+summed VERB O
+up ADP O
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+to PART O
+indicate VERB O
+the DET O
+self NOUN O
+- PUNCT O
+care NOUN O
+impairment NOUN O
+scores NOUN O
+for ADP O
+the DET O
+PWD PROPN B-AC
+. PUNCT O
+The DET O
+memory NOUN O
+and CCONJ O
+behavior NOUN O
+problems NOUN O
+of ADP O
+PWD PROPN B-AC
+were AUX O
+measured VERB O
+by ADP O
+the DET B-LF
+Revised PROPN I-LF
+Memory PROPN I-LF
+and CCONJ I-LF
+Behaviour PROPN I-LF
+Problems PROPN I-LF
+Checklist PROPN I-LF
+( PUNCT O
+RMBPC PROPN B-AC
+) PUNCT O
+[ PUNCT O
+27 NUM O
+] PUNCT O
+. PUNCT O
+
+Molecular ADJ O
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+for ADP O
+IDH1 NOUN B-AC
+- NOUN B-AC
+2 NUM B-AC
+wild ADJ O
+type NOUN O
+( PUNCT O
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+dehydrogenase NOUN I-LF
+type NOUN I-LF
+1 NUM I-LF
+and CCONJ I-LF
+2 NUM I-LF
+) PUNCT O
+, PUNCT O
+MGMT NOUN B-AC
+( PUNCT O
+O6 NOUN B-LF
+- NOUN I-LF
+Methylguanine NOUN I-LF
+- NOUN I-LF
+DNA NOUN I-LF
+methyl NOUN I-LF
+transferase NOUN I-LF
+) PUNCT O
+non ADJ O
+- NOUN O
+methylated VERB O
+, PUNCT O
+but CCONJ O
+not PART O
+1p/19q NOUN O
+co NOUN O
+- NOUN O
+deletion NOUN O
+were AUX O
+included VERB O
+( PUNCT O
+Fig PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+the DET O
+column NOUN O
+- ADJ O
+wise ADJ O
+sum NOUN O
+is AUX O
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+using VERB O
+the DET O
+R NOUN O
+matrix NOUN O
+, PUNCT O
+and CCONJ O
+a DET O
+threshold NOUN O
+is AUX O
+applied VERB O
+to PART O
+determine VERB O
+the DET O
+outer ADJ B-LF
+pericarp NOUN I-LF
+diameter NOUN I-LF
+( PUNCT O
+OPD NOUN B-AC
+) PUNCT O
+. PUNCT O
+This DET O
+approach NOUN O
+allows VERB O
+the DET O
+estimation NOUN O
+of ADP O
+an DET O
+average ADJ O
+OPD NOUN B-AC
+across ADP O
+all DET O
+the DET O
+radial ADJ O
+points NOUN O
+of ADP O
+the DET O
+stamp NOUN O
+, PUNCT O
+which PRON O
+can AUX O
+be AUX O
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+useful ADJ O
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+non ADJ O
+- ADJ O
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+fruit NOUN O
+stamps NOUN O
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+. PUNCT O
+
+Tissue NOUN O
+culture NOUN O
+infectious ADJ O
+dose NOUN O
+50 NUM O
+% NOUN O
+( PUNCT O
+TCID50 PROPN O
+) PUNCT O
+was AUX O
+determined VERB O
+by ADP O
+end NOUN B-LF
+- ADJ I-LF
+point NOUN I-LF
+dilution NOUN I-LF
+assays NOUN I-LF
+( PUNCT O
+EPDA PROPN B-AC
+) PUNCT O
+. PUNCT O
+Serial ADJ O
+10 NUM O
+- ADJ O
+fold ADJ O
+dilutions NOUN O
+of ADP O
+virus NOUN O
+stocks NOUN O
+and CCONJ O
+experimental ADJ O
+samples NOUN O
+were AUX O
+prepared VERB O
+in ADP O
+complete ADJ O
+DMEM PROPN B-AC
+cell NOUN O
+culture NOUN O
+medium NOUN O
+. PUNCT O
+
+The DET O
+RWC PROPN B-AC
+analysis NOUN O
+was AUX O
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+on ADP O
+10 NUM O
+days NOUN B-LF
+after ADP I-LF
+sowing NOUN I-LF
+( PUNCT O
+DAS NOUN B-AC
+) PUNCT O
+under ADP O
+control NOUN B-LF
+growth NOUN I-LF
+( PUNCT O
+CG PROPN B-AC
+) PUNCT O
+, PUNCT O
+25 NUM O
+DAS NOUN B-AC
+under ADP O
+drought NOUN O
+stress NOUN O
+and CCONJ O
+on ADP O
+38 NUM O
+DAS NOUN B-AC
+under ADP O
+re NOUN O
+- NOUN O
+watering NOUN O
+. PUNCT O
+
+The DET O
+human ADJ O
+GAIT PROPN O
+complex NOUN O
+is AUX O
+heterotetrameric NOUN O
+containing VERB O
+glutamyl NOUN B-LF
+- NOUN I-LF
+prolyl NOUN I-LF
+- NOUN I-LF
+tRNA NOUN I-LF
+synthetase NOUN I-LF
+( PUNCT O
+EPRS PROPN B-AC
+) PUNCT O
+, PUNCT O
+ribosomal ADJ O
+protein NOUN O
+L13a NOUN O
+, PUNCT O
+NS1 NOUN O
+- NOUN O
+associated VERB O
+protein–1 NOUN O
+, PUNCT O
+and CCONJ O
+glyceraldehyde NOUN B-LF
+3 NUM I-LF
+- NOUN I-LF
+phosphate NOUN I-LF
+dehydrogenase NOUN I-LF
+( PUNCT O
+GAPDH PROPN B-AC
+) PUNCT O
+[ PUNCT O
+11],[12 NUM O
+] PUNCT O
+. PUNCT O
+
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+. PUNCT O
+
+CAPs NOUN B-AC
+= PUNCT O
+Compound ADJ B-LF
+action NOUN I-LF
+potential ADJ I-LF
+recordings NOUN O
+immediately ADV O
+post ADV O
+- ADJ O
+operatively ADV O
+. PUNCT O
+
+Summary NOUN O
+statistics NOUN O
+for ADP O
+16 NUM O
+CVD NOUN B-AC
+outcomes NOUN O
+from ADP O
+the DET O
+Medical PROPN B-LF
+Research PROPN I-LF
+Council PROPN I-LF
+Integrative PROPN I-LF
+Epidemiology PROPN I-LF
+Unit PROPN I-LF
+( PUNCT O
+MRC PROPN B-AC
+- PUNCT B-AC
+IEU PROPN B-AC
+) PUNCT O
+UKB PROPN B-AC
+GWAS PROPN B-AC
+Pipeline PROPN O
+[ X O
+41 NUM O
+] X O
+( PUNCT O
+generated VERB O
+using VERB O
+the DET O
+PHEnome PROPN B-LF
+Scan PROPN I-LF
+Analysis PROPN I-LF
+Tool PROPN I-LF
+( PUNCT O
+PHESANT PROPN B-AC
+) PUNCT O
+[ X O
+42 NUM O
+] X O
+) PUNCT O
+and CCONJ O
+the DET O
+Neale PROPN O
+Lab PROPN O
+UKB PROPN B-AC
+GWAS PROPN B-AC
+[ X O
+36 NUM O
+] X O
+are AUX O
+listed VERB O
+in ADP O
+S1 PROPN O
+Table PROPN O
+. PUNCT O
+
+The DET B-LF
+Federal PROPN I-LF
+Office PROPN I-LF
+of ADP I-LF
+Public PROPN I-LF
+Health PROPN I-LF
+( PUNCT O
+FOPH PROPN B-AC
+) PUNCT O
+will AUX O
+define VERB O
+which DET O
+QIs NOUN B-AC
+will AUX O
+be AUX O
+collected VERB O
+at ADP O
+the DET O
+national ADJ O
+level NOUN O
+in ADP O
+near ADJ O
+future NOUN O
+. PUNCT O
+
+Blocking NOUN O
+and CCONJ O
+antibody NOUN O
+application NOUN O
+were AUX O
+as ADP O
+above ADV O
+except SCONJ O
+the DET O
+reaction NOUN O
+product NOUN O
+was AUX O
+visualized VERB O
+with ADP O
+a DET O
+diaminobenzidine NOUN B-LF
+( PUNCT O
+DAB PROPN B-AC
+) PUNCT O
+peroxidase NOUN O
+substrate NOUN O
+( PUNCT O
+Vector PROPN O
+Laboratories PROPN O
+, PUNCT O
+Burlingame PROPN O
+, PUNCT O
+CA PROPN O
+) PUNCT O
+, PUNCT O
+counterstained VERB O
+with ADP O
+1 NUM O
+% NOUN O
+Cresyl PROPN O
+Violet PROPN O
+( PUNCT O
+Sigma PROPN O
+, PUNCT O
+St. PROPN O
+Louis PROPN O
+, PUNCT O
+MO PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+cover NOUN O
+- PUNCT O
+slipped VERB O
+with ADP O
+Permount PROPN O
+( PUNCT O
+Fisher PROPN O
+Scientific PROPN O
+, PUNCT O
+Waltham PROPN O
+, PUNCT O
+MA PROPN O
+) PUNCT O
+. PUNCT O
+
+Laser PROPN B-LF
+Doppler PROPN I-LF
+flare NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+LDIFlare PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+quantitative ADJ B-LF
+thermal ADJ I-LF
+testing NOUN I-LF
+( PUNCT O
+QTT PROPN B-AC
+) PUNCT O
+are AUX O
+non ADJ O
+- ADJ O
+invasive ADJ O
+small ADJ O
+fiber NOUN O
+testing NOUN O
+modalities NOUN O
+, PUNCT O
+measuring VERB O
+small ADJ O
+nerve NOUN O
+fiber NOUN O
+function NOUN O
+, PUNCT O
+enabling VERB O
+objective ADJ O
+confirmation NOUN O
+of ADP O
+small ADJ O
+fiber NOUN O
+neuropathy NOUN O
+. PUNCT O
+
+Macrophages NOUN O
+were AUX O
+pretreated VERB O
+with ADP O
+buffer NOUN O
+, PUNCT O
+neutralizing VERB O
+antibodies NOUN O
+against ADP O
+TLR2 NOUN O
+( PUNCT O
+1 NUM O
+μg NOUN O
+/ ADP O
+ml NOUN O
+) PUNCT O
+, PUNCT O
+TAPI PROPN O
+( PUNCT O
+10 NUM O
+μg NOUN O
+/ ADP O
+ml NOUN O
+) PUNCT O
+, PUNCT O
+Bay PROPN O
+( PUNCT O
+100 NUM O
+μM NOUN O
+) PUNCT O
+, PUNCT O
+PD98059 NOUN O
+( PUNCT O
+20 NUM O
+μM NOUN O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+SB203580 NOUN O
+( PUNCT O
+10 NUM O
+μM NOUN O
+) PUNCT O
+for ADP O
+30 NUM O
+min NOUN O
+, PUNCT O
+and CCONJ O
+stimulated VERB O
+for ADP O
+2 NUM O
+h NOUN O
+with ADP O
+eRNA NOUN B-AC
+( PUNCT O
+10 NUM O
+μg NOUN O
+/ ADP O
+ml)/Pam2CSK4 NOUN O
+( PUNCT O
+Pam PROPN B-AC
+, PUNCT O
+0.1 NUM O
+ng NOUN O
+/ ADP O
+ml NOUN O
+) PUNCT O
+, PUNCT O
+which PRON O
+were AUX O
+preincubated VERB O
+for ADP O
+1 NUM O
+h NOUN O
+at ADP O
+37 NUM O
+° NOUN O
+C NOUN O
+. PUNCT O
+
+CR PROPN B-AC
+: PUNCT O
+Crown NOUN B-LF
+root NOUN I-LF
+, PUNCT O
+CK PROPN B-AC
+: PUNCT O
+Cytokinin PROPN B-LF
+, PUNCT O
+GA PROPN B-AC
+: PUNCT O
+Gibberellin NOUN B-LF
+, PUNCT O
+IAA PROPN B-AC
+: PUNCT O
+Auxin PROPN B-LF
+, PUNCT O
+QC PROPN O
+: PUNCT O
+Quiescent NOUN O
+center NOUN O
+. PUNCT O
+
+The DET O
+overlapped ADJ O
+pathways NOUN O
+derived VERB O
+from ADP O
+the DET O
+Kyoto PROPN B-LF
+Encyclopedia PROPN I-LF
+of ADP I-LF
+Genes PROPN I-LF
+and CCONJ I-LF
+Genomes PROPN I-LF
+( PUNCT O
+KEGG PROPN B-AC
+) PUNCT O
+and CCONJ O
+Reactome PROPN O
+databases NOUN O
+, PUNCT O
+comprising VERB O
+TGFβ NOUN B-AC
+signaling NOUN O
+, PUNCT O
+Hippo PROPN O
+signaling NOUN O
+, PUNCT O
+and CCONJ O
+phosphatidylinositol NOUN B-LF
+3 NUM I-LF
+kinase NOUN I-LF
+( PUNCT O
+PI3K)/v PROPN B-LF
+- PUNCT I-LF
+akt NOUN I-LF
+murine NOUN I-LF
+thymoma NOUN I-LF
+viral ADJ I-LF
+oncogene NOUN I-LF
+homolog NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+Akt PROPN B-AC
+) PUNCT O
+signaling NOUN O
+( PUNCT O
+Fig PROPN O
+2C NUM O
+) PUNCT O
+. PUNCT O
+Next ADV O
+, PUNCT O
+we PRON O
+explored VERB O
+the DET O
+role NOUN O
+of ADP O
+TGFβ NOUN B-AC
+/ SYM O
+Smad NOUN O
+signaling NOUN O
+in ADP O
+P. PROPN O
+gingivalis PROPN O
+- PUNCT O
+induced VERB O
+aggressiveness NOUN O
+of ADP O
+ESCC PROPN B-AC
+. PUNCT O
+Total ADJ O
+and CCONJ O
+active ADJ O
+TGFβ1 PROPN O
+secreted VERB O
+by ADP O
+P. PROPN O
+gingivalis PROPN O
+- PUNCT O
+treated VERB O
+NE6 PROPN O
+- PUNCT O
+T PROPN O
+and CCONJ O
+KYSE30 PROPN O
+cells NOUN O
+was AUX O
+significantly ADV O
+augmented VERB O
+compared VERB O
+with ADP O
+untreated ADJ O
+control NOUN O
+cells NOUN O
+( PUNCT O
+Fig PROPN O
+2D NUM O
+) PUNCT O
+. PUNCT O
+Additionally ADV O
+, PUNCT O
+P. PROPN O
+gingivalis PROPN O
+increased VERB O
+the DET O
+activation NOUN O
+of ADP O
+a DET O
+TGFβ NOUN B-AC
+- PUNCT O
+responsive ADJ O
+Smad NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+element NOUN I-LF
+( PUNCT O
+SBE PROPN B-AC
+) PUNCT O
+luciferase NOUN O
+reporter NOUN O
+in ADP O
+NE6 PROPN O
+- PUNCT O
+T PROPN O
+and CCONJ O
+KYSE30 PROPN O
+cells NOUN O
+at ADP O
+24 NUM O
+h NOUN O
+postinfection NOUN O
+. PUNCT O
+
+EuroFIT PROPN B-AC
+, PUNCT O
+European ADJ B-LF
+Fans NOUN I-LF
+in ADP I-LF
+Training NOUN I-LF
+. PUNCT O
+
+Excess ADJ O
+weight NOUN O
+, PUNCT O
+a DET O
+risk NOUN O
+factor NOUN O
+for ADP O
+hypertension NOUN O
+, PUNCT O
+diabetes NOUN O
+, PUNCT O
+and CCONJ O
+a DET O
+range NOUN O
+of ADP O
+other ADJ O
+noncommunicable ADJ B-LF
+diseases NOUN I-LF
+( PUNCT O
+NCDs PROPN B-AC
+) PUNCT O
+, PUNCT O
+has VERB O
+serious ADJ O
+implications NOUN O
+for ADP O
+economic ADJ O
+growth NOUN O
+in ADP O
+transitioning VERB O
+countries NOUN O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+Arabidopsis PROPN O
+has VERB O
+three NUM O
+Su(z)12 NOUN B-AC
+homologues NOUN O
+, PUNCT O
+EMBRYONIC PROPN B-LF
+FLOWER PROPN I-LF
+2 NUM I-LF
+( PUNCT O
+EMF2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+VERNALIZATION PROPN B-LF
+2 NUM I-LF
+( PUNCT O
+VRN2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+FERTILIZATION PROPN B-LF
+INDEPENDENT PROPN I-LF
+SEED PROPN I-LF
+( PUNCT O
+FIS2 PROPN B-AC
+) PUNCT O
+; PUNCT O
+one NUM O
+Esc PROPN O
+homologue NOUN O
+, PUNCT O
+FERTILIZATION PROPN B-LF
+INDEPENDENT PROPN I-LF
+ENDOSPERM PROPN I-LF
+( PUNCT O
+FIE PROPN B-AC
+) PUNCT O
+; PUNCT O
+and CCONJ O
+five NUM O
+p55 NOUN B-AC
+homologues NOUN O
+, PUNCT O
+MULTIPLE PROPN B-LF
+SUPPRESSOR PROPN I-LF
+OF ADP I-LF
+IRA PROPN I-LF
+1–5 NUM I-LF
+( PUNCT O
+MSI1–5 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Protein NOUN O
+levels NOUN O
+of ADP O
+Bbs PROPN O
+proteins NOUN O
+and CCONJ O
+synaptic ADJ O
+markers NOUN O
+were AUX O
+estimated VERB O
+by ADP O
+label NOUN O
+- NOUN O
+free ADJ O
+LC PROPN O
+- NOUN O
+MS PROPN O
+analyses NOUN O
+from ADP O
+following VERB O
+biochemical ADJ O
+fractions NOUN O
+of ADP O
+the DET O
+rat NOUN O
+hippocampi NOUN O
+: PUNCT O
+cytosolic ADJ O
+, PUNCT O
+detergent NOUN B-LF
+- NOUN I-LF
+soluble ADJ I-LF
+synaptosomal ADJ I-LF
+preparation NOUN O
+( PUNCT O
+DSS PROPN B-AC
+, PUNCT O
+pre ADV O
+- NOUN O
+synapse NOUN O
+enriched VERB O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+postsynaptic ADJ B-LF
+density NOUN I-LF
+preparation NOUN O
+( PUNCT O
+PSD PROPN B-AC
+) PUNCT O
+. PUNCT O
+Protein NOUN O
+levels NOUN O
+of ADP O
+the DET O
+presynaptic ADJ O
+( PUNCT O
+VGLU1 PROPN B-AC
+, PUNCT O
+SYP PROPN B-AC
+) PUNCT O
+and CCONJ O
+postsynaptic ADJ O
+( PUNCT O
+NMDAR1 PROPN O
+, PUNCT O
+PSD95 PROPN O
+) PUNCT O
+protein NOUN O
+markers NOUN O
+are AUX O
+enriched VERB O
+in ADP O
+DSS PROPN B-AC
+and CCONJ O
+PSD PROPN B-AC
+preparations NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+( PUNCT O
+B X O
+) PUNCT O
+The DET O
+protein NOUN O
+abundances NOUN O
+illustrated VERB O
+in ADP O
+the DET O
+heat NOUN O
+map NOUN O
+are AUX O
+obtained VERB O
+from ADP O
+the DET O
+total ADJ O
+MS1 PROPN O
+peptide NOUN O
+intensities NOUN O
+scaled VERB O
+to ADP O
+the DET O
+mean NOUN O
+of ADP O
+all DET O
+the DET O
+samples NOUN O
+. PUNCT O
+
+Single ADJ B-LF
+- PUNCT I-LF
+wavelength NOUN I-LF
+anomalous ADJ I-LF
+dispersion NOUN I-LF
+( PUNCT O
+SAD PROPN B-AC
+) PUNCT O
+data NOUN O
+from ADP O
+ethylmercury NOUN O
+phosphate NOUN O
+– PUNCT O
+soaked VERB O
+crystals NOUN O
+were AUX O
+collected VERB O
+using VERB O
+the DET O
+same ADJ O
+parameters NOUN O
+as ADP O
+native ADJ O
+data NOUN O
+, PUNCT O
+yielding VERB O
+the DET O
+same ADJ O
+space NOUN O
+group NOUN O
+with ADP O
+data NOUN O
+processed VERB O
+to ADP O
+2.3 NUM O
+Å. PUNCT O
+
+By ADP O
+comparison NOUN O
+of ADP O
+the DET O
+predicted VERB O
+and CCONJ O
+experimentally ADV O
+determined VERB O
+pIC50 NOUN O
+values NOUN O
+, PUNCT O
+the DET O
+statistical ADJ O
+parameters NOUN O
+R2 NOUN O
+( PUNCT O
+correlation NOUN O
+coefficient NOUN O
+) PUNCT O
+, PUNCT O
+SD NOUN B-AC
+( PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+of ADP I-LF
+regression NOUN I-LF
+) PUNCT O
+and CCONJ O
+Root PROPN O
+Mean PROPN O
+Square PROPN O
+Deviation PROPN O
+( PUNCT O
+RMSD NOUN O
+) PUNCT O
+were AUX O
+calculated VERB O
+to PART O
+evaluate VERB O
+the DET O
+overall ADJ O
+significance NOUN O
+of ADP O
+the DET O
+model NOUN O
+. PUNCT O
+
+IM PROPN B-AC
+, PUNCT O
+intermodulation NOUN B-LF
+; PUNCT O
+MSPCres PROPN B-AC
+, PUNCT O
+multispectral ADJ O
+phase NOUN O
+coherency NOUN O
+( PUNCT O
+response NOUN O
+) PUNCT O
+. PUNCT O
+
+Gender NOUN O
+- PUNCT O
+linked VERB O
+impact NOUN O
+of ADP O
+epicardial ADJ B-LF
+adipose ADJ I-LF
+tissue NOUN I-LF
+volume NOUN I-LF
+( PUNCT O
+EATV PROPN B-AC
+) PUNCT O
+in ADP O
+patients NOUN O
+undergoing VERB O
+coronary ADJ B-LF
+artery NOUN I-LF
+bypass NOUN I-LF
+grafting NOUN I-LF
+( PUNCT O
+CABG PROPN B-AC
+) PUNCT O
+remains VERB O
+unknown ADJ O
+. PUNCT O
+
+To PART O
+reflect VERB O
+ascertainment NOUN O
+bias NOUN O
+, PUNCT O
+we PRON O
+draw VERB O
+markers NOUN O
+from ADP O
+the DET O
+set NOUN O
+of ADP O
+SNPs NOUN B-AC
+having VERB O
+minor ADJ B-LF
+allele NOUN I-LF
+frequency NOUN I-LF
+( PUNCT O
+MAF NOUN B-AC
+) PUNCT O
+larger ADJ O
+than ADP O
+1 NUM O
+% PUNCT O
+. PUNCT O
+
+Cardiopulmonary ADJ B-LF
+exercise NOUN I-LF
+test NOUN I-LF
+( PUNCT O
+CPET PROPN B-AC
+) PUNCT O
+presents VERB O
+indisputable ADJ O
+clinical ADJ O
+applicability NOUN O
+for ADP O
+the DET O
+diagnosis NOUN O
+of ADP O
+exercise NOUN O
+intolerance NOUN O
+and CCONJ O
+its PRON O
+causes NOUN O
+, PUNCT O
+as ADV O
+well ADV O
+to PART O
+quantify VERB O
+cardiorespiratory ADJ B-LF
+fitness NOUN I-LF
+( PUNCT O
+CRF NOUN B-AC
+) PUNCT O
+[ PUNCT O
+1 NUM O
+, PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Among ADP O
+them PRON O
+, PUNCT O
+the DET O
+advanced ADJ O
+glycation NOUN O
+endproducts NOUN O
+( PUNCT O
+AGEs NOUN O
+) PUNCT O
+Nε NOUN B-LF
+- PUNCT I-LF
+carboxymethyllysine NOUN I-LF
+( PUNCT O
+CML PROPN B-AC
+) PUNCT O
+, PUNCT O
+pyrraline NOUN B-LF
+( PUNCT O
+Pyr PROPN B-AC
+) PUNCT O
+, PUNCT O
+methylglyoxal NOUN B-LF
+- PUNCT I-LF
+derived VERB I-LF
+hydroimidazolone NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+MG PROPN B-AC
+- PUNCT B-AC
+H1 PROPN B-AC
+) PUNCT O
+and CCONJ O
+Nε NOUN B-LF
+- PUNCT I-LF
+carboxyethyllysine NOUN I-LF
+( PUNCT O
+CEL PROPN B-AC
+) PUNCT O
+are AUX O
+the DET O
+quantitatively ADV O
+dominating VERB O
+compounds NOUN O
+during ADP O
+later ADJ O
+reaction NOUN O
+stages NOUN O
+. PUNCT O
+
+Part NOUN O
+B NOUN O
+participants NOUN O
+were AUX O
+vaccinated VERB O
+with ADP O
+A PROPN O
+/ NOUN O
+Singapore PROPN O
+/ NOUN O
+GP1908/2015 NUM O
+H1N1 NOUN O
+at ADP O
+15 NUM O
+, PUNCT O
+10 NUM O
+, PUNCT O
+5 NUM O
+, PUNCT O
+or CCONJ O
+2.5 NUM O
+μg NOUN O
+HA NOUN B-AC
+/ NOUN O
+dose NOUN O
+delivered VERB O
+by ADP O
+HD PROPN B-AC
+- PUNCT B-AC
+MAPs NOUN B-AC
+applied VERB O
+to ADP O
+the DET O
+volar ADJ O
+forearm NOUN B-LF
+( PUNCT O
+MAP PROPN B-AC
+- PUNCT O
+FA-15 PROPN B-AC
+, PUNCT O
+MAP PROPN B-AC
+- PUNCT O
+FA-10 PROPN B-AC
+, PUNCT O
+MAP PROPN B-AC
+- PUNCT O
+FA-5 PROPN B-AC
+, PUNCT O
+MAP PROPN B-AC
+- PUNCT O
+FA-2.5 NUM B-AC
+) PUNCT O
+, PUNCT O
+uncoated VERB O
+HD PROPN B-AC
+- PUNCT B-AC
+MAPs NOUN B-AC
+( PUNCT O
+MAP PROPN B-AC
+- PUNCT O
+FA-0 PROPN B-AC
+) PUNCT O
+, PUNCT O
+A PROPN O
+/ NOUN O
+Singapore PROPN O
+/ NOUN O
+GP1908/2015 NUM O
+H1N1 NOUN O
+at ADP O
+15 NUM O
+μg NOUN O
+HA NOUN B-AC
+/ NOUN O
+dose NOUN O
+delivered VERB O
+by ADP O
+HD PROPN B-AC
+- PUNCT B-AC
+MAP PROPN B-AC
+applied VERB O
+to ADP O
+the DET O
+upper ADJ B-LF
+arm NOUN I-LF
+( PUNCT O
+MAP PROPN B-AC
+- PUNCT O
+UA-15 PROPN B-AC
+) PUNCT O
+, PUNCT O
+or CCONJ O
+injected VERB O
+IM PROPN B-AC
+as ADP O
+a DET O
+component NOUN O
+of ADP O
+the DET O
+Afluria PROPN O
+quadrivalent ADJ O
+vaccine NOUN O
+( PUNCT O
+IM PROPN B-AC
+- PUNCT O
+QIV-15 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+aHR NOUN B-AC
+, PUNCT O
+adjusted VERB B-LF
+HR NOUN I-LF
+; PUNCT O
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+treatment NOUN I-LF
+; PUNCT O
+CD4 NOUN O
+, PUNCT O
+CD4 NOUN O
++ NUM O
+T NOUN O
+- PUNCT O
+lymphocyte NOUN O
+count NOUN O
+; PUNCT O
+cells NOUN O
+/ SYM O
+μL NOUN O
+, PUNCT O
+cells NOUN O
+per ADP O
+microliter NOUN O
+; PUNCT O
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+NA NOUN B-AC
+, PUNCT O
+not PART B-LF
+available ADJ I-LF
+
+We PRON O
+have AUX O
+previously ADV O
+reported VERB O
+that SCONJ O
+Ace PROPN B-AC
+potentiated VERB O
+ATP NOUN O
+stimulated VERB O
+chloride NOUN O
+secretion NOUN O
+in ADP O
+T84 NOUN O
+cells NOUN O
+via ADP O
+stimulation NOUN O
+of ADP O
+calcium NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+chloride NOUN I-LF
+channel NOUN I-LF
+( PUNCT O
+CaCC PROPN B-AC
+) PUNCT O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+. PUNCT O
+
+These DET O
+activities NOUN O
+were AUX O
+recorded VERB O
+both CCONJ O
+in ADP O
+the DET O
+extensor NOUN B-LF
+carpi NOUN I-LF
+radialis NOUN I-LF
+( PUNCT O
+ECR NOUN B-AC
+) PUNCT O
+and CCONJ O
+flexor NOUN B-LF
+carpi NOUN I-LF
+radialis NOUN I-LF
+( PUNCT O
+FCR NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+did AUX O
+not PART O
+seem VERB O
+to PART O
+have VERB O
+any DET O
+relationship NOUN O
+with ADP O
+the DET O
+illusions NOUN O
+. PUNCT O
+
+Pi NOUN B-AC
+, PUNCT O
+phosphate NOUN B-LF
+. PUNCT O
+
+MITI PROPN B-AC
+= PUNCT O
+Motivational ADJ B-LF
+Interviewing NOUN I-LF
+Treatment PROPN I-LF
+Integrity PROPN I-LF
+Code PROPN I-LF
+
+Following VERB O
+the DET O
+ideas NOUN O
+of ADP O
+Fosang PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+and CCONJ O
+Dallmeijer PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+, PUNCT O
+who PRON O
+used VERB O
+a DET O
+similar ADJ O
+approach NOUN O
+in ADP O
+individuals NOUN O
+with ADP O
+cerebral ADJ O
+palsy NOUN O
+, PUNCT O
+we PRON O
+wanted VERB O
+to PART O
+compare VERB O
+the DET O
+maximum ADJ B-LF
+isometric ADJ I-LF
+joint ADJ I-LF
+moments NOUN I-LF
+( PUNCT O
+MIM PROPN B-AC
+) PUNCT O
+of ADP O
+people NOUN O
+with ADP O
+TFA PROPN B-AC
+with ADP O
+the DET O
+corresponding ADJ O
+joint ADJ O
+moments NOUN O
+during ADP O
+walking VERB O
+as SCONJ O
+determined VERB O
+by ADP O
+conventional ADJ B-LF
+clinical ADJ I-LF
+gait NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+CGA PROPN B-AC
+) PUNCT O
+[ PUNCT O
+27–29 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+healthy ADJ O
+pancreatic ADJ O
+β NOUN O
+- PUNCT O
+cells NOUN O
+insulin NOUN O
+is AUX O
+secreted VERB O
+when SCONJ O
+elevated VERB O
+glucose NOUN O
+availability NOUN O
+increases VERB O
+mitochondrial ADJ O
+energy NOUN O
+metabolism NOUN O
+, PUNCT O
+hyperpolarizing VERB O
+the DET O
+mitochondrial ADJ B-LF
+membrane NOUN I-LF
+potential NOUN I-LF
+( PUNCT O
+ΔψM NOUN B-AC
+) PUNCT O
+, PUNCT O
+raising VERB O
+the DET O
+cytoplasmic ADJ O
+ATP NOUN O
+/ SYM O
+ADP NOUN O
+ratio NOUN O
+, PUNCT O
+closing VERB O
+ATP NOUN B-LF
+- PUNCT I-LF
+sensitive ADJ I-LF
+K+-channels NOUN I-LF
+( PUNCT O
+KATP NOUN B-AC
+) PUNCT O
+, PUNCT O
+depolarizing VERB O
+the DET O
+plasma NOUN B-LF
+membrane NOUN I-LF
+potential NOUN I-LF
+( PUNCT O
+ΔψP NOUN B-AC
+) PUNCT O
+, PUNCT O
+activating VERB O
+Ca2 NOUN O
++ NOUN O
+entry NOUN O
+and CCONJ O
+triggering VERB O
+exocytosis NOUN O
+. PUNCT O
+
+FHS PROPN B-AC
+, PUNCT O
+Family PROPN B-LF
+Health PROPN I-LF
+Strategy PROPN I-LF
+; PUNCT O
+HR PROPN O
+, PUNCT O
+hazard NOUN O
+ratio NOUN O
+; PUNCT O
+IPTW PROPN O
+, PUNCT O
+inverse ADJ O
+probability NOUN O
+treatment NOUN O
+weighting NOUN O
+. PUNCT O
+
+BMI NOUN B-AC
+: PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+, PUNCT O
+CRP NOUN B-AC
+: PUNCT O
+C NOUN B-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+
+CC PROPN B-LF
+chemokine NOUN I-LF
+receptor NOUN I-LF
+type NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+CCR2 PROPN B-AC
+) PUNCT O
+mediates VERB O
+muscle NOUN O
+recruitment NOUN O
+of ADP O
+monocytes NOUN B-LF
+/ SYM O
+macrophages NOUN B-LF
+( PUNCT O
+MOs NOUN B-AC
+/ SYM O
+MPs NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+CCR2 PROPN B-AC
+- PUNCT O
+mediated VERB O
+inflammation NOUN O
+is AUX O
+essential ADJ O
+to ADP O
+the DET O
+acute ADJ O
+skeletal ADJ O
+muscle NOUN O
+injury NOUN O
+repair NOUN O
+[ PUNCT O
+24 NUM O
+, PUNCT O
+55–61 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+inflorescence NOUN B-LF
+type NOUN I-LF
+( PUNCT O
+IT NOUN B-AC
+) PUNCT O
+was AUX O
+uniparous ADJ O
+in ADP O
+51 NUM O
+( PUNCT O
+41.4 NUM O
+% PUNCT O
+) PUNCT O
+genotypes NOUN O
+, PUNCT O
+biparous ADJ O
+in ADP O
+52 NUM O
+( PUNCT O
+42.3 NUM O
+% PUNCT O
+) PUNCT O
+and CCONJ O
+multiparous ADJ O
+in ADP O
+20 NUM O
+( PUNCT O
+16.3 NUM O
+% PUNCT O
+) PUNCT O
+. PUNCT O
+
+EEG NOUN B-AC
+, PUNCT O
+electroencephalography NOUN B-LF
+. PUNCT O
+
+Then ADV O
+the DET O
+therapeutic ADJ O
+effects NOUN O
+of ADP O
+SP PROPN B-AC
+- NOUN B-AC
+GNP PROPN B-AC
+and CCONJ O
+pure ADJ O
+SP PROPN B-AC
+solution NOUN O
+on ADP O
+6 NUM B-AC
+- NOUN B-AC
+OHDA PROPN B-AC
+induced VERB O
+hemiparkinsonian ADJ O
+rats NOUN O
+were AUX O
+assessed VERB O
+by ADP O
+quantifying VERB O
+rotational ADJ O
+behavior NOUN O
+and CCONJ O
+the DET O
+levels NOUN O
+of ADP O
+tyrosine NOUN B-LF
+hydroxylase NOUN I-LF
+( PUNCT O
+TH NOUN B-AC
+) PUNCT O
+, PUNCT O
+phosphorylated VERB B-LF
+c NOUN I-LF
+- NOUN I-LF
+Jun PROPN I-LF
+protein NOUN I-LF
+( PUNCT O
+p NOUN B-AC
+- NOUN B-AC
+c NOUN B-AC
+- NOUN B-AC
+Jun PROPN B-AC
+) PUNCT O
+and CCONJ O
+Caspase-3 NOUN B-LF
+( PUNCT O
+Cas-3 NOUN B-AC
+) PUNCT O
+expressed VERB O
+in ADP O
+substantia X B-LF
+nigra NOUN I-LF
+( PUNCT O
+SN PROPN B-AC
+) PUNCT O
+region NOUN O
+. PUNCT O
+
+( PUNCT O
+a X O
+) PUNCT O
+Sustained ADJ O
+exposure NOUN O
+to ADP O
+AA PROPN B-AC
+is AUX O
+harmful ADJ O
+for ADP O
+proximal ADJ B-LF
+tubular ADJ I-LF
+epithelial ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PTEC PROPN B-AC
+) PUNCT O
+leading VERB O
+to ADP O
+incomplete ADJ O
+proliferation NOUN O
+of ADP O
+PTEC PROPN B-AC
+resulting VERB O
+in ADP O
+apoptosis NOUN O
+inhibition NOUN O
+. PUNCT O
+
+DF PROPN O
+, PUNCT O
+degrees NOUN O
+of ADP O
+freedom NOUN O
+; PUNCT O
+FREQ PROPN O
+, PUNCT O
+amplitude NOUN O
+frequency NOUN O
+; PUNCT O
+MTL PROPN B-AC
+, PUNCT O
+medial ADJ B-LF
+temporal ADJ I-LF
+lobe NOUN I-LF
+; PUNCT O
+OFC PROPN B-AC
+, PUNCT O
+orbitofrontal ADJ B-LF
+cortex NOUN I-LF
+; PUNCT O
+PAC PROPN B-AC
+, PUNCT O
+phase NOUN B-LF
+- PUNCT I-LF
+amplitude NOUN I-LF
+coupling NOUN I-LF
+. PUNCT O
+
+CV NOUN B-AC
+= PUNCT O
+Cardiovascular ADJ B-LF
+
+( PUNCT O
+A NOUN O
+, PUNCT O
+B NOUN O
+) PUNCT O
+Nociceptive ADJ O
+hypersensitivity NOUN O
+in ADP O
+the DET O
+intraplantar ADJ O
+formalin NOUN O
+test NOUN O
+( PUNCT O
+phase NOUN O
+II NUM O
+) PUNCT O
+is AUX O
+significantly ADV O
+reduced VERB O
+upon SCONJ O
+intrathecal ADJ O
+delivery NOUN O
+of ADP O
+an DET O
+IP3R PROPN O
+blocker NOUN O
+( PUNCT O
+2 NUM O
+- PUNCT O
+APB PROPN O
+) PUNCT O
+or CCONJ O
+an DET O
+inhibitor NOUN O
+of ADP O
+MLC PROPN B-AC
+phosphorylation NOUN O
+( PUNCT O
+ML-7 PROPN O
+) PUNCT O
+in ADP O
+wild ADJ O
+- PUNCT O
+type NOUN O
+mice NOUN O
+( PUNCT O
+A NOUN O
+) PUNCT O
+. PUNCT O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− NOUN O
+mice NOUN O
+show VERB O
+significantly ADV O
+reduced VERB O
+formalin NOUN O
+responses NOUN O
+than ADP O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+littermates NOUN O
+( PUNCT O
+B NOUN O
+) PUNCT O
+. PUNCT O
+( PUNCT O
+C X O
+) PUNCT O
+Comparison NOUN O
+of ADP O
+response NOUN O
+frequency NOUN O
+to ADP O
+von PROPN O
+Frey PROPN O
+hairs NOUN O
+in ADP O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− NOUN O
+mice NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+10 NUM O
+; PUNCT O
+red ADJ O
+squares NOUN O
+) PUNCT O
+and CCONJ O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+mice NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+10 NUM O
+; PUNCT O
+black ADJ O
+squares NOUN O
+) PUNCT O
+prior ADV O
+to ADP O
+and CCONJ O
+at ADP O
+12 NUM O
+h NOUN O
+and CCONJ O
+24 NUM O
+h NOUN O
+following VERB O
+unilateral ADJ O
+hindpaw NOUN O
+inflammation NOUN O
+caused VERB O
+by ADP O
+intraplantar ADJ O
+injection NOUN O
+of ADP O
+Complete PROPN B-LF
+Freund PROPN I-LF
+'s PART I-LF
+adjuvant NOUN I-LF
+( PUNCT O
+CFA PROPN B-AC
+) PUNCT O
+. PUNCT O
+Note VERB O
+that SCONJ O
+leftward ADJ O
+deviations NOUN O
+in ADP O
+stimulus NOUN O
+- PUNCT O
+response NOUN O
+curves NOUN O
+in ADP O
+the DET O
+inflamed VERB O
+state NOUN O
+over ADP O
+the DET O
+basal ADJ O
+state NOUN O
+are AUX O
+much ADV O
+less ADV O
+pronounced ADJ O
+in ADP O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− NOUN O
+mice NOUN O
+as SCONJ O
+compared VERB O
+with ADP O
+their PRON O
+control NOUN O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+littermates NOUN O
+. PUNCT O
+( PUNCT O
+D NOUN O
+, PUNCT O
+E NOUN O
+) PUNCT O
+Magnitude NOUN O
+and CCONJ O
+time NOUN O
+- PUNCT O
+course NOUN O
+of ADP O
+mechanical ADJ O
+hypersensitivity NOUN O
+to ADP O
+plantar ADJ O
+von PROPN O
+Frey PROPN O
+hair NOUN O
+application NOUN O
+( PUNCT O
+panel NOUN O
+D NOUN O
+) PUNCT O
+and CCONJ O
+thermal ADJ O
+hyperalgesia NOUN O
+to ADP O
+radiant ADJ O
+heat NOUN O
+( PUNCT O
+panel NOUN O
+E NOUN O
+) PUNCT O
+following VERB O
+unilateral ADJ O
+hindpaw NOUN O
+inflammation NOUN O
+caused VERB O
+by ADP O
+intraplantar ADJ O
+injection NOUN O
+of ADP O
+Complete PROPN B-LF
+Freund PROPN I-LF
+'s PART I-LF
+adjuvant NOUN I-LF
+( PUNCT O
+CFA PROPN B-AC
+) PUNCT O
+to ADP O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− NOUN O
+and CCONJ O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+mice NOUN O
+are AUX O
+shown VERB O
+. PUNCT O
+* PUNCT O
+p<0.05 NUM O
+as SCONJ O
+compared VERB O
+to ADP O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+mice NOUN O
+, PUNCT O
+† PUNCT O
+p<0.05 NUM O
+in ADP O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+mice NOUN O
+or CCONJ O
+in ADP O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− NOUN O
+mice NOUN O
+as SCONJ O
+compared VERB O
+to ADP O
+their PRON O
+own ADJ O
+basal ADJ O
+values NOUN O
+, PUNCT O
+and CCONJ O
+ANOVA NOUN O
+of ADP O
+random ADJ O
+measures NOUN O
+followed VERB O
+by ADP O
+post X O
+hoc X O
+Fisher PROPN O
+'s PART O
+test NOUN O
+. PUNCT O
+( PUNCT O
+F NOUN O
+) PUNCT O
+Analysis NOUN O
+of ADP O
+excitability NOUN O
+of ADP O
+peripheral ADJ O
+nociceptors NOUN O
+in ADP O
+PKG PROPN O
+- PUNCT O
+Ifl PROPN O
+/ SYM O
+fl PROPN O
+mice NOUN O
+and CCONJ O
+SNS PROPN O
+- PUNCT O
+PKG PROPN B-AC
+- PUNCT B-AC
+I−/− NOUN O
+mice NOUN O
+. PUNCT O
+
+HHT PROPN B-AC
+= PUNCT O
+Hereditary ADJ B-LF
+Hemorrhagic PROPN I-LF
+Telangiectasia PROPN I-LF
+
+Table NOUN O
+2 NUM O
+and CCONJ O
+3 NUM O
+: PUNCT O
+CaCx NOUN B-AC
+should AUX O
+read VERB O
+: PUNCT O
+cervical ADJ B-LF
+cancer NOUN I-LF
+
+CDA PROPN B-AC
+, PUNCT O
+complete ADJ B-LF
+diagnostic ADJ I-LF
+autopsy NOUN I-LF
+; PUNCT O
+MIA PROPN B-AC
+, PUNCT O
+minimally ADV B-LF
+invasive ADJ I-LF
+autopsy NOUN I-LF
+. PUNCT O
+
+Clinical ADJ O
+information NOUN O
+was AUX O
+provided VERB O
+by ADP O
+the DET O
+Asan PROPN B-LF
+BiomedicaL PROPN I-LF
+Research PROPN I-LF
+Environment PROPN I-LF
+( PUNCT O
+ABLE PROPN B-AC
+) PUNCT O
+system NOUN O
+. PUNCT O
+
+We PRON O
+addressed VERB O
+the DET O
+issue NOUN O
+in ADP O
+an DET O
+individual ADJ O
+- NOUN O
+participant ADJ O
+meta NOUN O
+- NOUN O
+analysis NOUN O
+of ADP O
+5,008 NUM O
+people NOUN O
+not PART O
+being AUX O
+treated VERB O
+for ADP O
+hypertension NOUN O
+randomly ADV O
+recruited VERB O
+from ADP O
+five NUM O
+populations NOUN O
+and CCONJ O
+enrolled VERB O
+in ADP O
+the DET O
+International PROPN B-LF
+Database PROPN I-LF
+of ADP I-LF
+Home PROPN I-LF
+Blood PROPN I-LF
+Pressure PROPN I-LF
+in ADP I-LF
+Relation PROPN I-LF
+to ADP I-LF
+Cardiovascular PROPN I-LF
+Outcome PROPN I-LF
+( PUNCT O
+IDHOCO PROPN B-AC
+) PUNCT O
+[ PUNCT O
+8],[9 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+utilized VERB O
+our PRON O
+automated VERB O
+algorithm NOUN O
+to PART O
+examine VERB O
+the DET O
+relationship NOUN O
+between ADP O
+vessel NOUN O
+density NOUN O
+, PUNCT O
+estimated VERB O
+via ADP O
+automated VERB O
+analysis NOUN O
+, PUNCT O
+and CCONJ O
+best ADV B-LF
+corrected VERB I-LF
+visual ADJ I-LF
+acuity NOUN I-LF
+( PUNCT O
+BCVA PROPN B-AC
+) PUNCT O
+and CCONJ O
+CRT NOUN B-AC
+at ADP O
+the DET O
+baseline NOUN O
+visit NOUN O
+of ADP O
+patients NOUN O
+enrolled VERB O
+in ADP O
+the DET O
+RECOVERY PROPN O
+trial NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
+paper NOUN O
+describes VERB O
+the DET O
+recommendations NOUN O
+of ADP O
+The DET O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+Initiative PROPN O
+on ADP O
+what PRON O
+should AUX O
+be AUX O
+included VERB O
+in ADP O
+an DET O
+accurate ADJ O
+and CCONJ O
+complete ADJ O
+report NOUN O
+of ADP O
+an DET O
+observational ADJ O
+study NOUN O
+. PUNCT O
+
+The DET O
+identification NOUN O
+of ADP O
+mutations NOUN O
+in ADP O
+important ADJ O
+coronary ADJ O
+artery NOUN O
+disease NOUN O
+associated VERB O
+genes NOUN O
+has AUX O
+led VERB O
+to PART O
+the DET O
+development NOUN O
+of ADP O
+new ADJ O
+drugs NOUN O
+and CCONJ O
+the DET O
+approach NOUN O
+of ADP O
+Mendelian ADJ B-LF
+randomization NOUN I-LF
+( PUNCT O
+MR NOUN B-AC
+) PUNCT O
+is AUX O
+widely ADV O
+used VERB O
+to PART O
+predict VERB O
+the DET O
+effect NOUN O
+of ADP O
+interventions NOUN O
+on ADP O
+biomarkers NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+, PUNCT O
+to PART O
+validate VERB O
+drug NOUN O
+targets NOUN O
+and CCONJ O
+to PART O
+predict VERB O
+the DET O
+effect NOUN O
+of ADP O
+drug NOUN O
+combinations NOUN O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Granulomatosis NOUN B-LF
+with ADP I-LF
+polyangiitis NOUN I-LF
+( PUNCT O
+GPA PROPN B-AC
+) PUNCT O
+is AUX O
+an DET O
+autoimmune ADJ O
+disease NOUN O
+affecting VERB O
+mainly ADV O
+small ADJ O
+blood NOUN O
+vessels NOUN O
+. PUNCT O
+
+Upon SCONJ O
+ligand NOUN O
+binding VERB O
+, PUNCT O
+the DET O
+Notch PROPN B-LF
+intracellular ADJ I-LF
+domain NOUN I-LF
+( PUNCT O
+NICD PROPN B-AC
+) PUNCT O
+travels VERB O
+to ADP O
+the DET O
+nucleus NOUN O
+, PUNCT O
+binds VERB O
+to ADP O
+RBPJ PROPN B-AC
+( PUNCT O
+recombination NOUN B-LF
+signal NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+for ADP I-LF
+immunoglobulin NOUN I-LF
+kappa NOUN I-LF
+J NOUN I-LF
+region NOUN I-LF
+) PUNCT O
+, PUNCT O
+and CCONJ O
+mediates VERB O
+gene NOUN O
+transcription NOUN O
+[ PUNCT O
+19 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
+study NOUN O
+was AUX O
+conducted VERB O
+to PART O
+directly ADV O
+inform VERB O
+the DET O
+deliberations NOUN O
+of ADP O
+the DET O
+Advisory PROPN B-LF
+Committee PROPN I-LF
+on ADP I-LF
+Immunization PROPN I-LF
+Practices PROPN I-LF
+( PUNCT O
+ACIP PROPN B-AC
+) PUNCT O
+to PART O
+guide VERB O
+HPV PROPN B-AC
+vaccination NOUN O
+policy NOUN O
+for ADP O
+women NOUN O
+and CCONJ O
+men NOUN O
+in ADP O
+the DET O
+United PROPN O
+States PROPN O
+. PUNCT O
+
+Error NOUN O
+bars NOUN O
+represent VERB O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+( PUNCT O
+SEM PROPN B-AC
+) PUNCT O
+. PUNCT O
+Data NOUN O
+were AUX O
+examined VERB O
+for ADP O
+normal ADJ O
+distribution NOUN O
+and CCONJ O
+variance NOUN O
+to PART O
+determine VERB O
+if SCONJ O
+any DET O
+datasets NOUN O
+needed VERB O
+further ADJ O
+analysis NOUN O
+. PUNCT O
+
+The DET O
+N NOUN O
+- PUNCT O
+terminal NOUN O
+Gly NOUN O
+and CCONJ O
+the DET O
+GCN4 NOUN O
+sequence NOUN O
+in ADP O
+αTM1a1 PROPN O
+- PUNCT O
+14Zip PROPN O
+are AUX O
+shown VERB O
+in ADP O
+small ADJ O
+letters NOUN O
+. PUNCT O
+2D NOUN O
+, PUNCT O
+two NUM O
+- PUNCT O
+dimensional ADJ O
+; PUNCT O
+HSQC PROPN B-AC
+, PUNCT O
+heteronuclear ADJ B-LF
+single ADJ I-LF
+- PUNCT I-LF
+quantum ADJ I-LF
+coherence NOUN I-LF
+; PUNCT O
+Lmod NOUN B-AC
+, PUNCT O
+leiomodin NOUN B-LF
+. PUNCT O
+
+NS5A PROPN O
+also ADV O
+attenuates VERB O
+IFN PROPN B-AC
+action NOUN O
+by ADP O
+inducing VERB O
+expression NOUN O
+and CCONJ O
+secretion NOUN O
+of ADP O
+interleukin NOUN B-LF
+( PUNCT O
+IL)-8 NUM B-AC
+, PUNCT O
+a DET O
+pro ADJ O
+- PUNCT O
+inflammatory ADJ O
+chemokine NOUN O
+that PRON O
+interferes VERB O
+with ADP O
+IFN PROPN B-AC
+through ADP O
+alterations NOUN O
+in ADP O
+IFN PROPN B-LF
+- PUNCT I-LF
+stimulated VERB I-LF
+genes NOUN I-LF
+( PUNCT O
+ISG PROPN B-AC
+) PUNCT O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+cystic ADJ B-LF
+fibrosis NOUN I-LF
+( PUNCT O
+CF PROPN B-AC
+) PUNCT O
+, PUNCT O
+lung NOUN O
+damage NOUN O
+is AUX O
+mediated VERB O
+by ADP O
+a DET O
+cycle NOUN O
+of ADP O
+obstruction NOUN O
+, PUNCT O
+infection NOUN O
+, PUNCT O
+and CCONJ O
+inflammation NOUN O
+. PUNCT O
+
+Our PRON O
+analysis NOUN O
+of ADP O
+distributive ADJ B-LF
+conjugal ADJ I-LF
+transfer NOUN I-LF
+( PUNCT O
+DCT PROPN B-AC
+) PUNCT O
+in ADP O
+M. PROPN O
+smegmatis PROPN O
+has VERB O
+practical ADJ O
+and CCONJ O
+conceptual ADJ O
+ramifications NOUN O
+. PUNCT O
+
+After SCONJ O
+further ADJ O
+adjustments NOUN O
+were AUX O
+made VERB O
+for ADP O
+the DET O
+indices NOUN O
+of ADP O
+waist NOUN B-LF
+circumference NOUN I-LF
+( PUNCT O
+WC NOUN B-AC
+) PUNCT O
+, PUNCT O
+fasting VERB B-LF
+blood NOUN I-LF
+glucose NOUN I-LF
+( PUNCT O
+FBG NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+blood NOUN O
+lipids NOUN O
+( PUNCT O
+TG NOUN B-AC
+and CCONJ O
+HDL NOUN B-AC
+- PUNCT B-AC
+C NOUN B-AC
+) PUNCT O
+alone ADV O
+or CCONJ O
+in ADP O
+combination NOUN O
+, PUNCT O
+the DET O
+correlations NOUN O
+were AUX O
+slightly ADV O
+attenuated VERB O
+, PUNCT O
+but CCONJ O
+remained VERB O
+statistically ADV O
+significant ADJ O
+( PUNCT O
+all DET O
+P NOUN O
+trend<0.001 NUM O
+) PUNCT O
+. PUNCT O
+
+Odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+) PUNCT O
+, PUNCT O
+sensitivity NOUN O
+, PUNCT O
+specificity NOUN O
+, PUNCT O
+positive ADJ B-LF
+and CCONJ I-LF
+negative ADJ I-LF
+predictive ADJ I-LF
+values NOUN I-LF
+( PUNCT O
+PPV NOUN B-AC
+and CCONJ B-AC
+NPV PROPN B-AC
+) PUNCT O
+, PUNCT O
+positive ADJ O
+and CCONJ O
+negative ADJ O
+likelihood NOUN O
+ratios NOUN O
+, PUNCT O
+and CCONJ O
+area NOUN O
+under ADP O
+the DET O
+receiver NOUN B-LF
+operator NOUN I-LF
+characteristic ADJ I-LF
+( PUNCT O
+AUROC PROPN B-AC
+) PUNCT O
+curve NOUN O
+are AUX O
+reported VERB O
+. PUNCT O
+
+AFASS PROPN B-AC
+— PUNCT O
+affordable ADJ O
+, PUNCT O
+feasible ADJ O
+, PUNCT O
+acceptable ADJ O
+sustainable ADJ O
+and CCONJ O
+safe ADJ O
+, PUNCT O
+ART- PROPN B-AC
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+, PUNCT O
+HAART PROPN B-AC
+— PUNCT O
+highly ADV B-LF
+active ADJ I-LF
+antiretroviral ADJ I-LF
+treatment NOUN I-LF
+, PUNCT O
+NVP PROPN B-AC
+— PUNCT O
+Nevirapine PROPN B-LF
+, PUNCT O
+ZDV PROPN B-AC
+— PUNCT O
+Zidovudine PROPN B-LF
+, PUNCT O
+3TC- PROPN B-AC
+Lamuvudine PROPN B-LF
+
+Our PRON O
+first ADJ O
+management NOUN O
+reference NOUN O
+point NOUN O
+for ADP O
+reserve NOUN O
+coverage NOUN O
+policy NOUN O
+decisions NOUN O
+( PUNCT O
+the DET O
+“ PUNCT O
+maximum ADJ O
+biodiversity NOUN O
+benefit NOUN O
+without ADP O
+fisheries NOUN O
+costs NOUN O
+” PUNCT O
+) PUNCT O
+was AUX O
+based VERB O
+on ADP O
+the DET O
+assumption NOUN O
+that SCONJ O
+even ADV O
+regularly ADV O
+assessed VERB O
+and CCONJ O
+controlled VERB O
+fisheries NOUN O
+in ADP O
+developed VERB O
+countries NOUN O
+are AUX O
+difficult ADJ O
+to ADP O
+maintain VERB O
+close ADV O
+to ADP O
+MSY PROPN B-AC
+or CCONJ O
+maximum ADJ B-LF
+economic ADJ I-LF
+yield NOUN I-LF
+( PUNCT O
+MEY PROPN B-AC
+) PUNCT O
+[ PUNCT O
+28,54 NUM O
+] PUNCT O
+. PUNCT O
+
+Multivariable ADV O
+- PUNCT O
+adjusted VERB O
+Poisson PROPN O
+regression NOUN O
+was AUX O
+used VERB O
+to PART O
+identify VERB O
+factors NOUN O
+associated VERB O
+with ADP O
+hospitalization NOUN O
+rates NOUN O
+, PUNCT O
+including VERB O
+demographics NOUN O
+, PUNCT O
+blood NOUN O
+pressure NOUN O
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+eGFR NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+proteinuria NOUN O
+. PUNCT O
+
+ADAR1 PROPN B-AC
+, PUNCT O
+adenosine NOUN B-LF
+deaminase NOUN I-LF
+acting VERB I-LF
+on ADP I-LF
+RNA NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+AGS1 PROPN O
+, PUNCT O
+Aicardi PROPN O
+- PUNCT O
+Goutières PROPN O
+Syndrome PROPN O
+type NOUN O
+1 NUM O
+; PUNCT O
+AGS2 PROPN O
+, PUNCT O
+Aicardi PROPN O
+- PUNCT O
+Goutières PROPN O
+Syndrome PROPN O
+type NOUN O
+2 NUM O
+; PUNCT O
+AGS4 PROPN O
+, PUNCT O
+Aicardi PROPN O
+- PUNCT O
+Goutières PROPN O
+Syndrome PROPN O
+type NOUN O
+4 NUM O
+; PUNCT O
+AGS5 PROPN O
+, PUNCT O
+Aicardi PROPN O
+- PUNCT O
+Goutières PROPN O
+Syndrome PROPN O
+type NOUN O
+5 NUM O
+; PUNCT O
+RNAseq PROPN B-AC
+, PUNCT O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+; PUNCT O
+UTR PROPN B-AC
+, PUNCT O
+untranslated ADJ B-LF
+region NOUN I-LF
+; PUNCT O
+VOPP1 PROPN B-AC
+, PUNCT O
+vesicular ADJ B-LF
+, PUNCT I-LF
+overexpressed VERB I-LF
+in ADP I-LF
+cancer NOUN I-LF
+, PUNCT I-LF
+prosurvival ADJ I-LF
+protein NOUN I-LF
+1 NUM I-LF
+. PUNCT O
+
+Psychological ADJ O
+interventions NOUN O
+were AUX O
+defined VERB O
+as ADP O
+interventions NOUN O
+incorporating VERB O
+a DET O
+structured ADJ O
+and CCONJ O
+explicitly ADV O
+psychological ADJ O
+approach NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+cognitive ADJ B-LF
+behavior NOUN I-LF
+therapy NOUN I-LF
+( PUNCT O
+CBT PROPN B-AC
+) PUNCT O
+or CCONJ O
+interpersonal ADJ B-LF
+therapy NOUN I-LF
+( PUNCT O
+IPT PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Principal ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+PCA PROPN B-AC
+) PUNCT O
+clustering NOUN O
+and CCONJ O
+variance NOUN O
+explained VERB O
+. PUNCT O
+
+LD NOUN B-AC
+, PUNCT O
+long ADJ B-LF
+- PUNCT I-LF
+day NOUN I-LF
+; PUNCT O
+SD PROPN B-AC
+, PUNCT O
+short ADJ B-LF
+- PUNCT I-LF
+day NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+The DET O
+authors NOUN O
+used VERB O
+two NUM O
+sets NOUN O
+of ADP O
+lipidomics NOUN O
+data NOUN O
+( PUNCT O
+" PUNCT O
+1061 NUM O
+participants NOUN O
+of ADP O
+the DET O
+FINRISK PROPN O
+2012 NUM O
+population NOUN O
+cohort NOUN O
+" PUNCT O
+and CCONJ O
+" PUNCT O
+250 NUM O
+randomly ADV O
+chosen VERB O
+participants NOUN O
+of ADP O
+the DET O
+Malmö PROPN O
+Diet PROPN O
+and CCONJ O
+Cancer PROPN O
+Cardiovascular PROPN O
+Cohort PROPN O
+" PUNCT O
+) PUNCT O
+to PART O
+build VERB O
+and CCONJ O
+test VERB O
+the DET O
+regression NOUN O
+model NOUN O
+for ADP O
+predicting VERB O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+, PUNCT O
+waist NOUN B-LF
+circumference NOUN I-LF
+( PUNCT O
+WC PROPN B-AC
+) PUNCT O
+, PUNCT O
+waist NOUN B-LF
+- PUNCT I-LF
+hip NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+WHR NOUN B-AC
+) PUNCT O
+and CCONJ O
+body NOUN B-LF
+fat NOUN I-LF
+percentage NOUN I-LF
+( PUNCT O
+BFP PROPN B-AC
+) PUNCT O
+with ADP O
+consideration NOUN O
+of ADP O
+gender NOUN O
+and CCONJ O
+age NOUN O
+. PUNCT O
+
+The DET O
+main ADJ O
+mRNA NOUN B-LF
+decapping NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+Dcp2 NOUN B-AC
+) PUNCT O
+mediates VERB O
+the DET O
+decapping NOUN O
+of ADP O
+almost ADV O
+all PRON O
+major ADJ O
+ATG NOUN O
+mRNAs NOUN O
+, PUNCT O
+whereas SCONJ O
+the DET O
+RNA NOUN O
+exoribonuclease NOUN B-LF
+1 NUM I-LF
+( PUNCT O
+Xrn1 NOUN B-AC
+) PUNCT O
+is AUX O
+responsible ADJ O
+for ADP O
+the DET O
+degradation NOUN O
+of ADP O
+some PRON O
+of ADP O
+them PRON O
+. PUNCT O
+
+LAA% NOUN B-AC
+: PUNCT O
+percentage NOUN O
+of ADP O
+lung NOUN O
+field NOUN O
+occupied VERB O
+by ADP O
+low ADJ B-LF
+attenuation NOUN I-LF
+areas NOUN I-LF
+; PUNCT O
+LAA_n NOUN B-AC
+: PUNCT O
+number NOUN B-LF
+of ADP I-LF
+LAA PROPN I-LF
+cluster NOUN I-LF
+. PUNCT O
+
+Furthermore ADV O
+, PUNCT O
+no DET O
+modification NOUN O
+of ADP O
+morphology NOUN O
+was AUX O
+observed VERB O
+with ADP O
+the DET O
+wild ADJ B-LF
+- NOUN I-LF
+type NOUN I-LF
+α NOUN B-AC
+- NOUN B-AC
+syn NOUN B-AC
+protein NOUN O
+( PUNCT O
+WT PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+E46 PROPN O
+K PROPN O
+mutant NOUN O
+. PUNCT O
+
+SA PROPN O
+, PUNCT O
+sphinganine NOUN O
+; PUNCT O
+SO NOUN O
+, PUNCT O
+sphingosine NOUN O
+; PUNCT O
+TG NOUN B-AC
+, PUNCT O
+triglycerides NOUN B-LF
+
+By ADP O
+harnessing VERB O
+specific ADJ O
+chemical ADJ O
+signatures NOUN O
+, PUNCT O
+Magnetic PROPN B-LF
+Resonance PROPN I-LF
+Spectroscopy PROPN I-LF
+( PUNCT O
+MRS PROPN B-AC
+) PUNCT O
+techniques NOUN O
+detecting VERB O
+weak ADJ O
+but CCONJ O
+cell NOUN O
+- ADJ O
+specific ADJ O
+metabolic ADJ O
+signals NOUN O
+could AUX O
+open VERB O
+a DET O
+unique ADJ O
+window NOUN O
+to ADP O
+performing VERB O
+similar ADJ O
+observations NOUN O
+in ADP O
+a DET O
+non ADJ O
+- ADJ O
+invasive ADJ O
+, PUNCT O
+in ADP O
+vivo ADJ O
+fashion NOUN O
+[ X O
+7–11 NUM O
+] PUNCT O
+. PUNCT O
+
+SD NOUN B-AC
+: PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+AKI PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+kidney NOUN I-LF
+injury NOUN I-LF
+; PUNCT O
+ALI PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+lung NOUN I-LF
+injury NOUN I-LF
+; PUNCT O
+DIC PROPN B-AC
+, PUNCT O
+disseminated VERB B-LF
+intravascular ADJ I-LF
+coagulation NOUN I-LF
+; PUNCT O
+LOS PROPN B-AC
+, PUNCT O
+length NOUN B-LF
+of ADP I-LF
+stay NOUN I-LF
+; PUNCT O
+MODS PROPN B-AC
+, PUNCT O
+multi ADJ B-LF
+- ADJ I-LF
+organ ADJ I-LF
+dysfunction NOUN I-LF
+syndrome NOUN I-LF
+; PUNCT O
+MV PROPN B-AC
+, PUNCT O
+mechanical ADJ B-LF
+ventilation NOUN I-LF
+; PUNCT O
+PICU PROPN B-AC
+, PUNCT O
+pediatric ADJ B-LF
+intensive ADJ I-LF
+care NOUN I-LF
+unit NOUN I-LF
+; PUNCT O
+RRT PROPN B-AC
+, PUNCT O
+renal ADJ B-LF
+replacement NOUN I-LF
+therapy NOUN I-LF
+. PUNCT O
+
+In ADP O
+order NOUN O
+to ADP O
+fate NOUN O
+map VERB O
+candidate NOUN O
+neural ADJ O
+stem NOUN O
+cells NOUN O
+close ADJ O
+to ADP O
+the DET O
+central ADJ O
+canal NOUN O
+, PUNCT O
+we PRON O
+generated VERB O
+two NUM O
+transgenic ADJ O
+mouse NOUN O
+lines NOUN O
+expressing VERB O
+tamoxifen NOUN B-LF
+- PUNCT I-LF
+dependent ADJ I-LF
+Cre PROPN I-LF
+recombinase NOUN I-LF
+( PUNCT O
+CreER PROPN B-AC
+) PUNCT O
+under ADP O
+the DET O
+control NOUN O
+of ADP O
+FoxJ1 PROPN O
+( PUNCT O
+HFH4 PROPN O
+) PUNCT O
+or CCONJ O
+Nestin PROPN O
+regulatory ADJ O
+sequences NOUN O
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+OR PROPN B-AC
+, PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+. PUNCT O
+
+A DET O
+set NOUN O
+of ADP O
+400 NUM O
+test NOUN O
+peptides NOUN O
+of ADP O
+the DET O
+general ADJ O
+form NOUN O
+X PROPN O
+- PUNCT O
+Z PROPN O
+- PUNCT O
+Gly PROPN O
+- PUNCT O
+Pro PROPN O
+were AUX O
+docked VERB O
+to ADP O
+a DET O
+subset NOUN O
+of ADP O
+cyclophilin NOUN O
+isoforms NOUN O
+( PUNCT O
+Protein PROPN B-LF
+Data PROPN I-LF
+Bank PROPN I-LF
+[ X O
+PDB PROPN B-AC
+] PUNCT O
+codes NOUN O
+: PUNCT O
+PPIA PROPN O
+, PUNCT O
+1AK4 PROPN O
+: PUNCT O
+PPIL2 PROPN O
+, PUNCT O
+1ZKC PROPN O
+; PUNCT O
+PPIC PROPN O
+, PUNCT O
+2ESL PROPN O
+; PUNCT O
+PPWD1 PROPN O
+, PUNCT O
+2A2N PROPN O
+; PUNCT O
+and CCONJ O
+NKTR PROPN O
+, PUNCT O
+2HE9 NUM O
+) PUNCT O
+using VERB O
+ICM PROPN O
+software NOUN O
+( PUNCT O
+Molsoft PROPN O
+LLC PROPN O
+) PUNCT O
+. PUNCT O
+Monte PROPN O
+Carlo PROPN O
+simulations NOUN O
+were AUX O
+performed VERB O
+to ADP O
+sample VERB O
+conformational ADJ O
+space NOUN O
+for ADP O
+each DET O
+combination NOUN O
+of ADP O
+cyclophilin NOUN O
+isoform NOUN O
+and CCONJ O
+test NOUN O
+peptide NOUN O
+, PUNCT O
+allowing VERB O
+flexibility NOUN O
+of ADP O
+the DET O
+tetrapeptide NOUN O
+and CCONJ O
+the DET O
+sidechains NOUN O
+of ADP O
+the DET O
+gatekeepers NOUN O
+at ADP O
+positions NOUN O
+comparable ADJ O
+to ADP O
+PPIA PROPN O
+Thr73 PROPN O
+, PUNCT O
+Lys82 PROPN O
+, PUNCT O
+and CCONJ O
+Ala103 PROPN O
+, PUNCT O
+and CCONJ O
+keeping VERB O
+the DET O
+rest NOUN O
+of ADP O
+the DET O
+protein NOUN O
+receptor NOUN O
+rigid ADJ O
+[ X O
+64 NUM O
+] PUNCT O
+. PUNCT O
+
+From ADP O
+these DET O
+subgroup NOUN O
+analyses NOUN O
+only ADV O
+the DET O
+odds NOUN B-LF
+ratio NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+) PUNCT O
+of ADP O
+the DET O
+HEMS NOUN B-AC
+( PUNCT O
+relative ADJ O
+to ADP O
+GEMS PROPN B-AC
+) PUNCT O
+was AUX O
+reported VERB O
+, PUNCT O
+with ADP O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+. PUNCT O
+
+cBMI NOUN B-AC
+, PUNCT O
+corrected VERB B-LF
+body NOUN I-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+DBP PROPN B-AC
+, PUNCT O
+diastolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+; PUNCT O
+ECW PROPN B-AC
+, PUNCT O
+extracellular ADJ B-LF
+water NOUN I-LF
+; PUNCT O
+eGFR NOUN B-AC
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+HbA1C PROPN B-AC
+, PUNCT O
+hemoglobin NOUN B-LF
+A1C NOUN I-LF
+; PUNCT O
+HDL PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+cholesterol NOUN I-LF
+; PUNCT O
+hs NOUN B-AC
+- PUNCT B-AC
+CRP PROPN B-AC
+high ADJ O
+- PUNCT O
+sensitivity NOUN O
+C PROPN O
+reactive ADJ O
+protein NOUN O
+; PUNCT O
+iPTH PROPN B-AC
+, PUNCT O
+intact ADJ B-LF
+parathyroid ADJ I-LF
+hormone NOUN I-LF
+; PUNCT O
+LAD PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+atrial ADJ I-LF
+dimension NOUN I-LF
+; PUNCT O
+LAVI PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+atrial ADJ I-LF
+volume NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+LDL PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+cholesterol NOUN I-LF
+; PUNCT O
+LVEDD PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastolic ADJ I-LF
+dimension NOUN I-LF
+; PUNCT O
+LVEF PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+ejection NOUN I-LF
+fraction NOUN I-LF
+; PUNCT O
+LVEDV PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastolic ADJ I-LF
+volume NOUN I-LF
+; PUNCT O
+LVH PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+hypertrophy NOUN I-LF
+; PUNCT O
+LVMI PROPN B-AC
+, PUNCT O
+left ADJ B-LF
+ventricular ADJ I-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+NT NOUN B-AC
+- PUNCT B-AC
+proBNP PROPN B-AC
+, PUNCT O
+N NOUN B-LF
+- PUNCT I-LF
+terminal ADJ I-LF
+prohormone NOUN I-LF
+of ADP I-LF
+B NOUN I-LF
+- PUNCT I-LF
+type NOUN I-LF
+natriuretic ADJ I-LF
+peptide NOUN I-LF
+; PUNCT O
+OH PROPN B-AC
+, PUNCT O
+overhydration NOUN B-LF
+; PUNCT O
+RWT PROPN B-AC
+, PUNCT O
+relative ADJ B-LF
+wall NOUN I-LF
+thickness NOUN I-LF
+; PUNCT O
+SBP NOUN B-AC
+, PUNCT O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+; PUNCT O
+TBW PROPN B-AC
+, PUNCT O
+total ADJ B-LF
+body NOUN I-LF
+water NOUN I-LF
+. PUNCT O
+
+TB PROPN B-AC
+: PUNCT O
+tuberculosis NOUN B-LF
+, PUNCT O
+QFT PROPN B-AC
+: PUNCT O
+QuantiFERON PROPN B-LF
+- PUNCT I-LF
+TB PROPN I-LF
+Gold PROPN I-LF
+In PROPN I-LF
+- PUNCT I-LF
+Tube PROPN I-LF
+, PUNCT O
+TST NOUN B-AC
+: PUNCT O
+Tuberculin PROPN B-LF
+Skin PROPN I-LF
+Test PROPN I-LF
+. PUNCT O
+
+The DET O
+following ADJ O
+TaqManAssay PROPN O
+- PUNCT O
+on ADP O
+- PUNCT O
+Demand NOUN O
+primer NOUN O
+sets NOUN O
+for ADP O
+mouse NOUN O
+gene NOUN O
+expression NOUN O
+analysis NOUN O
+were AUX O
+purchased VERB O
+from ADP O
+Invitrogen PROPN O
+: PUNCT O
+AnxA6 PROPN O
+( PUNCT O
+mAnxA6 PROPN O
+, PUNCT O
+Mm00478966_m1 NOUN O
+) PUNCT O
+, PUNCT O
+carnitine NOUN B-LF
+palmitoyltransferase NOUN I-LF
+1A PROPN I-LF
+( PUNCT O
+CPT1α PROPN B-AC
+; PUNCT O
+mCpt1a NOUN O
+liver NOUN O
+, PUNCT O
+Mm00550438_m1 NOUN O
+) PUNCT O
+, PUNCT O
+fatty NOUN O
+acid NOUN O
+synthase NOUN O
+( PUNCT O
+mFasn PROPN O
+, PUNCT O
+Mm00662319_m1 NOUN O
+) PUNCT O
+, PUNCT O
+fibroblast NOUN O
+growth NOUN O
+factor NOUN O
+21 NUM O
+( PUNCT O
+Fgf21 PROPN O
+; PUNCT O
+mFgf21 PROPN O
+, PUNCT O
+Mm00840165_g1 NOUN O
+) PUNCT O
+, PUNCT O
+glucose-6 NOUN O
+phosphatase NOUN O
+( PUNCT O
+G6P PROPN B-AC
+) PUNCT O
+catalytic ADJ O
+( PUNCT O
+mG6pc PROPN O
+, PUNCT O
+Mm00839363_m1 NOUN O
+) PUNCT O
+, PUNCT O
+solute NOUN O
+carrier NOUN O
+family NOUN O
+2 NUM O
+( PUNCT O
+facilitated VERB O
+glucose NOUN O
+transporter NOUN O
+) PUNCT O
+, PUNCT O
+member NOUN O
+2 NUM O
+( PUNCT O
+SLC2A2 PROPN O
+, PUNCT O
+GLUT2 PROPN O
+; PUNCT O
+mSlc2a2 PROPN O
+, PUNCT O
+mGlut2 PROPN O
+, PUNCT O
+Mm00446224_m1 NOUN O
+) PUNCT O
+, PUNCT O
+insulin NOUN O
+induced VERB O
+gene NOUN O
+1 NUM O
+( PUNCT O
+Insig1 PROPN O
+; PUNCT O
+mInsig1 PROPN O
+, PUNCT O
+Mm00463389_m1 NOUN O
+) PUNCT O
+, PUNCT O
+hydroxyacyl NOUN O
+- PUNCT O
+Coenzyme NOUN O
+A PROPN O
+dehydrogenase/3 NOUN O
+- PUNCT O
+ketoacyl NOUN O
+- PUNCT O
+Coenzyme NOUN O
+A PROPN O
+thiolase NOUN O
+/ SYM O
+enoyl NOUN O
+- PUNCT O
+Coenzyme NOUN O
+A PROPN O
+hydratase NOUN O
+( PUNCT O
+trifunctional ADJ O
+protein NOUN O
+) PUNCT O
+, PUNCT O
+α NOUN O
+( PUNCT O
+mHadha X O
+, PUNCT O
+Mm00805228_m1 NOUN O
+) PUNCT O
+and CCONJ O
+β NOUN O
+subunit NOUN O
+( PUNCT O
+mHadhb NOUN O
+, PUNCT O
+Mm00523880_g1 NOUN O
+, PUNCT O
+LDLR NOUN O
+( PUNCT O
+mLdlr NOUN O
+, PUNCT O
+Mm00440169_m1 NOUN O
+) PUNCT O
+, PUNCT O
+pyruvate NOUN O
+dehydrogenase NOUN O
+lipoamide NOUN O
+kinase NOUN O
+isozyme NOUN O
+4 NUM O
+( PUNCT O
+mPdk4 NOUN O
+, PUNCT O
+Mm00443325_m1 NOUN O
+) PUNCT O
+, PUNCT O
+TATA PROPN O
+- PUNCT O
+box NOUN O
+binding VERB O
+protein NOUN O
+( PUNCT O
+Tbp NOUN O
+; PUNCT O
+mTbp NOUN O
+( PUNCT O
+Mm00446973_m1 NOUN O
+) PUNCT O
+. PUNCT O
+
+To PART O
+explore VERB O
+the DET O
+underlying VERB O
+mechanism NOUN O
+for ADP O
+the DET O
+rescue NOUN O
+effect NOUN O
+of ADP O
+E2 PROPN B-AC
+treatment NOUN O
+in ADP O
+response NOUN O
+to ADP O
+TCF7L2DN NOUN B-AC
+- PUNCT O
+mediated VERB O
+functional ADJ O
+knockdown NOUN O
+; PUNCT O
+we PRON O
+tested VERB O
+the DET O
+in ADP O
+vitro X O
+effect NOUN O
+of ADP O
+E2 PROPN B-AC
+in ADP O
+MPH NOUN B-AC
+. PUNCT O
+We PRON O
+found VERB O
+that SCONJ O
+6 NUM O
+- PUNCT O
+hour NOUN O
+E2 PROPN B-AC
+treatment NOUN O
+stimulated VERB O
+β NOUN B-AC
+- PUNCT B-AC
+cat NOUN B-AC
+Ser675 NOUN O
+phosphorylation NOUN O
+( PUNCT O
+Fig PROPN O
+4A NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+stimulation NOUN O
+increased VERB O
+along ADP O
+with ADP O
+the DET O
+treatment NOUN O
+time NOUN O
+within ADP O
+the DET O
+120 NUM O
+- PUNCT O
+minute NOUN O
+experimental ADJ O
+time NOUN O
+( PUNCT O
+Fig PROPN O
+4B NUM O
+) PUNCT O
+. PUNCT O
+E2 PROPN B-AC
+treatment NOUN O
+also ADV O
+transiently ADV O
+increased VERB O
+cAMP NOUN B-LF
+response NOUN I-LF
+element NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+( PUNCT O
+CREB PROPN B-AC
+) PUNCT O
+phosphorylation NOUN O
+( PUNCT O
+Ser133 PROPN O
+) PUNCT O
+( PUNCT O
+at ADP O
+15 NUM O
+minutes NOUN O
+, PUNCT O
+S6 PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+As ADP O
+in ADP O
+the DET O
+case NOUN O
+of ADP O
+anterior ADJ B-LF
+- PUNCT I-LF
+posterior ADJ I-LF
+( PUNCT O
+AP PROPN B-AC
+) PUNCT O
+patterning NOUN O
+, PUNCT O
+where SCONJ O
+apparently ADV O
+species NOUN O
+- PUNCT O
+specific ADJ O
+upstream ADJ O
+processes NOUN O
+activate VERB O
+HOX NOUN O
+genes NOUN O
+in ADP O
+a DET O
+conserved VERB O
+order NOUN O
+along ADP O
+the DET O
+AP PROPN B-AC
+axis NOUN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+, PUNCT O
+distinct ADJ O
+pathways NOUN O
+have AUX O
+been AUX O
+implicated VERB O
+in ADP O
+DV PROPN B-AC
+patterning NOUN O
+of ADP O
+the DET O
+neuroectoderm NOUN O
+. PUNCT O
+
+The DET O
+expression NOUN O
+of ADP O
+PGC-1α NOUN O
+and CCONJ O
+FOXO1 PROPN O
+further ADV O
+enhanced ADJ O
+by ADP O
+day NOUN O
+6 NUM O
+, PUNCT O
+furthermore ADV O
+, PUNCT O
+PGC-1β NOUN O
+, PUNCT O
+another DET O
+key ADJ O
+mitotropic ADJ O
+regulator NOUN O
+[ X O
+24–26 NUM O
+] X O
+boosted VERB O
+upon SCONJ O
+AICAR+MTX PROPN B-AC
+treatment NOUN O
+( PUNCT O
+Fig PROPN O
+3C NUM O
+) PUNCT O
+. PUNCT O
+Consequently ADV O
+, PUNCT O
+on ADP O
+day NOUN O
+6 NUM O
+enhanced ADJ O
+expression NOUN O
+of ADP O
+ATP5g1 NOUN O
+and CCONJ O
+IDH2 PROPN B-AC
+in ADP O
+the DET O
+AICAR+MTX PROPN B-AC
+treated VERB O
+cells NOUN O
+was AUX O
+exacerbated VERB O
+, PUNCT O
+moreover ADV O
+, PUNCT O
+other ADJ O
+TCA PROPN O
+cycle NOUN O
+enzymes NOUN O
+, PUNCT O
+fumarase NOUN O
+and CCONJ O
+aconitase-2 NOUN B-LF
+( PUNCT O
+ACO2 PROPN B-AC
+) PUNCT O
+were AUX O
+also ADV O
+induced VERB O
+( PUNCT O
+Fig PROPN O
+3C NUM O
+) PUNCT O
+. PUNCT O
+
+At ADP O
+least ADV O
+eight NUM O
+genotypes NOUN O
+of ADP O
+Hepatitis PROPN B-LF
+B PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+HBV PROPN B-AC
+) PUNCT O
+have AUX O
+been AUX O
+identified VERB O
+. PUNCT O
+
+This DET O
+subset NOUN O
+includes VERB O
+molecules NOUN O
+such ADJ O
+as ADP O
+vascular ADJ B-LF
+endothelial ADJ I-LF
+cadherin NOUN I-LF
+( PUNCT O
+VE PROPN B-AC
+- PUNCT B-AC
+Cadherin PROPN B-AC
+) PUNCT O
+, PUNCT O
+platelet NOUN B-LF
+endothelial ADJ I-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+( PUNCT O
+PECAM-1 PROPN B-AC
+) PUNCT O
+( PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+[ X O
+CD]31 X B-AC
+) PUNCT O
+, PUNCT O
+CD99 NOUN O
+, PUNCT O
+endothelial ADJ B-LF
+cell NOUN I-LF
+- PUNCT I-LF
+selective ADJ I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+( PUNCT O
+ESAM PROPN B-AC
+) PUNCT O
+, PUNCT O
+intercellular ADJ O
+adhesion NOUN O
+molecule NOUN O
+1 NUM O
+and CCONJ O
+2 NUM O
+( PUNCT O
+ICAM-1 PROPN O
+and CCONJ O
+-2 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+junctional ADJ O
+adhesion NOUN O
+molecule NOUN O
+( PUNCT O
+JAM PROPN O
+) PUNCT O
+family NOUN O
+of ADP O
+proteins NOUN O
+( PUNCT O
+JAM PROPN O
+- PUNCT O
+A PROPN O
+, PUNCT O
+B PROPN O
+, PUNCT O
+and CCONJ O
+C PROPN O
+) PUNCT O
+[ X O
+2,6 NUM O
+] PUNCT O
+. PUNCT O
+
+Urine NOUN O
+specimens NOUN O
+were AUX O
+submitted VERB O
+for ADP O
+immediate ADJ O
+analysis NOUN O
+of ADP O
+urine NOUN O
+pH NOUN O
+, PUNCT O
+urine NOUN B-LF
+specific ADJ I-LF
+gravity NOUN I-LF
+( PUNCT O
+USG PROPN B-AC
+) PUNCT O
+, PUNCT O
+routine ADJ O
+dipstick NOUN O
+analysis NOUN O
+, PUNCT O
+semi ADJ O
+- ADJ O
+quantitative ADJ O
+urine NOUN O
+sediment NOUN O
+analysis NOUN O
+, PUNCT O
+and CCONJ O
+calculation NOUN O
+of ADP O
+urine NOUN B-LF
+protein NOUN I-LF
+: PUNCT I-LF
+creatinine NOUN I-LF
+( PUNCT O
+UPC PROPN B-AC
+) PUNCT O
+ratio NOUN O
+. PUNCT O
+
+In ADP O
+this DET O
+paper NOUN O
+, PUNCT O
+we PRON O
+develop VERB O
+an DET O
+individual NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+model NOUN I-LF
+( PUNCT O
+IBM PROPN B-AC
+) PUNCT O
+to PART O
+study VERB O
+potential ADJ O
+mechanisms NOUN O
+for ADP O
+coexistence NOUN O
+of ADP O
+multiple ADJ O
+epitope NOUN O
+- PUNCT O
+specific ADJ O
+T PROPN O
+cell NOUN O
+populations NOUN O
+. PUNCT O
+
+Acta2 PROPN B-AC
+, PUNCT O
+smooth ADJ B-LF
+muscle NOUN I-LF
+actin NOUN I-LF
+alpha NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+Col1ɑ1 PROPN B-AC
+, PUNCT O
+collagen NOUN B-LF
+type NOUN I-LF
+I NOUN I-LF
+ɑ NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+Col1ɑ2 NOUN O
+, PUNCT O
+collagen NOUN O
+type NOUN O
+I NOUN O
+ɑ NOUN O
+2 NUM O
+; PUNCT O
+Emcn PROPN B-AC
+, PUNCT O
+endomucin NOUN B-LF
+; PUNCT O
+Epi PROPN O
+, PUNCT O
+epicardium NOUN O
+; PUNCT O
+Lox PROPN B-AC
+, PUNCT O
+lysyl NOUN B-LF
+oxidase NOUN I-LF
+; PUNCT O
+LV PROPN O
+, PUNCT O
+left ADJ O
+ventricular ADJ O
+; PUNCT O
+MI PROPN B-AC
+, PUNCT O
+myocardial ADJ B-LF
+infarction NOUN I-LF
+; PUNCT O
+Myo PROPN O
+, PUNCT O
+myocardium NOUN O
+; PUNCT O
+NS PROPN O
+, PUNCT O
+non ADJ O
+- PUNCT O
+significant ADJ O
+; PUNCT O
+p4ha1 PROPN O
+, PUNCT O
+prolyl NOUN O
+4 NUM O
+- PUNCT O
+hydroxylase NOUN O
+subunit NOUN O
+alpha-1 NOUN O
+; PUNCT O
+plod2 PROPN O
+, PUNCT O
+procollagen NOUN O
+- PUNCT O
+lysine,2 NOUN O
+- PUNCT O
+oxoglutarate NOUN O
+5 NUM O
+- PUNCT O
+dioxygenase NOUN O
+2 NUM O
+; PUNCT O
+Plod2b PROPN O
+, PUNCT O
+procollagen NOUN O
+- PUNCT O
+lysine,2 NOUN O
+- PUNCT O
+oxoglutarate NOUN O
+5 NUM O
+- PUNCT O
+dioxygenase NOUN O
+2b NUM O
+; PUNCT O
+qRT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+, PUNCT O
+real ADJ B-LF
+- PUNCT I-LF
+time NOUN I-LF
+quantitative ADJ I-LF
+reverse ADJ I-LF
+transcription NOUN I-LF
+PCR NOUN I-LF
+; PUNCT O
+Tagln PROPN B-AC
+, PUNCT O
+transgelin NOUN B-LF
+; PUNCT O
+TAZ PROPN B-AC
+, PUNCT O
+transcriptional ADJ B-LF
+coactivator NOUN I-LF
+with ADP I-LF
+PDZ NOUN I-LF
+- PUNCT I-LF
+binding VERB I-LF
+motif NOUN I-LF
+; PUNCT O
+Timp1 PROPN B-AC
+, PUNCT O
+tissue NOUN B-LF
+inhibitor NOUN I-LF
+matrix NOUN I-LF
+metalloproteinase NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+Vcam1 PROPN B-AC
+, PUNCT O
+vascular ADJ B-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+Vegf PROPN O
+, PUNCT O
+vascular ADJ O
+endothelial ADJ O
+growth NOUN O
+factor NOUN O
+; PUNCT O
+YAP PROPN B-AC
+, PUNCT O
+yes NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+protein NOUN I-LF
+; PUNCT O
+YAP PROPN B-AC
+/ SYM B-AC
+TAZ PROPN B-AC
+- PUNCT B-AC
+dKO PROPN B-AC
+, PUNCT O
+YAP PROPN B-LF
+/ SYM I-LF
+TAZ PROPN I-LF
+double ADJ I-LF
+knockout NOUN I-LF
+. PUNCT O
+
+BG PROPN B-AC
+, PUNCT O
+Bergmann PROPN B-LF
+glia NOUN I-LF
+; PUNCT O
+E PROPN O
+, PUNCT O
+embryonic ADJ O
+day NOUN O
+; PUNCT O
+GLA PROPN B-AC
+, PUNCT O
+granular ADJ B-LF
+layer NOUN I-LF
+astrocyte NOUN I-LF
+; PUNCT O
+GLAp PROPN B-AC
+, PUNCT O
+granular ADJ B-LF
+layer NOUN I-LF
+astrocyte NOUN I-LF
+precursor NOUN I-LF
+; PUNCT O
+HetC PROPN B-AC
+, PUNCT O
+heterogeneous ADJ B-LF
+clone NOUN I-LF
+; PUNCT O
+HomC PROPN B-AC
+, PUNCT O
+homogeneous ADJ B-LF
+clone NOUN I-LF
+; PUNCT O
+MP PROPN B-AC
+, PUNCT O
+multiple ADJ O
+progenitor NOUN O
+; PUNCT O
+P PROPN O
+, PUNCT O
+postnatal ADJ O
+day NOUN O
+; PUNCT O
+PCLp PROPN B-AC
+, PUNCT O
+Purkinje PROPN B-LF
+cell NOUN I-LF
+layer NOUN I-LF
+precursor NOUN I-LF
+; PUNCT O
+PWM PROPN B-AC
+, PUNCT O
+prospective ADJ B-LF
+white ADJ I-LF
+matter NOUN I-LF
+; PUNCT O
+WMA PROPN B-AC
+, PUNCT O
+white ADJ B-LF
+matter NOUN I-LF
+astrocyte NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+adjOR NOUN B-AC
+, PUNCT O
+adjusted ADJ B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+ref NOUN O
+, PUNCT O
+reference NOUN O
+
+NA PROPN B-AC
+agents NOUN O
+have VERB O
+a DET O
+high ADJ O
+rate NOUN O
+of ADP O
+success NOUN O
+in ADP O
+suppressing VERB O
+detectable ADJ O
+viraemia NOUN O
+, PUNCT O
+but CCONJ O
+do AUX O
+not PART O
+tackle VERB O
+the DET O
+liver NOUN O
+reservoir NOUN O
+of ADP O
+virus NOUN O
+( PUNCT O
+in ADP O
+the DET O
+form NOUN O
+of ADP O
+covalently ADV B-LF
+closed ADJ I-LF
+circular ADJ I-LF
+DNA NOUN I-LF
+( PUNCT O
+cccDNA NOUN B-AC
+) PUNCT O
+in ADP O
+the DET O
+nucleus NOUN O
+of ADP O
+infected ADJ O
+hepatocytes NOUN O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+) PUNCT O
+, PUNCT O
+so SCONJ O
+most ADJ O
+individuals NOUN O
+are AUX O
+committed VERB O
+to ADP O
+long ADJ O
+- PUNCT O
+term NOUN O
+treatment NOUN O
+. PUNCT O
+
+Stress NOUN O
+myocardial ADJ O
+perfusion NOUN O
+positron NOUN B-LF
+emission NOUN I-LF
+tomography NOUN I-LF
+( PUNCT O
+PET NOUN B-AC
+) PUNCT O
+allows VERB O
+for ADP O
+measurement NOUN O
+of ADP O
+absolute ADJ O
+myocardial ADJ B-LF
+blood NOUN I-LF
+flow NOUN I-LF
+( PUNCT O
+MBF NOUN B-AC
+) PUNCT O
+and CCONJ O
+quantification NOUN O
+of ADP O
+global ADJ O
+left VERB O
+ventricular ADJ O
+coronary ADJ B-LF
+flow NOUN I-LF
+reserve NOUN I-LF
+( PUNCT O
+CFR NOUN B-AC
+) PUNCT O
+. PUNCT O
+A DET O
+CFR NOUN B-AC
+< ADP O
+2.0 NUM O
+is AUX O
+considered VERB O
+impaired ADJ O
+coronary ADJ O
+vascular ADJ O
+function NOUN O
+, PUNCT O
+and CCONJ O
+it PRON O
+is AUX O
+associated VERB O
+with ADP O
+increased VERB O
+cardiovascular ADJ O
+risk NOUN O
+. PUNCT O
+
+The DET O
+region NOUN O
+of ADP O
+Southeast PROPN B-LF
+Tibet PROPN I-LF
+shrublands NOUN I-LF
+and CCONJ I-LF
+meadows NOUN I-LF
+( PUNCT O
+STSM PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+accounted VERB O
+for ADP O
+43.4 NUM O
+% NOUN O
+of ADP O
+the DET O
+total ADJ O
+area NOUN O
+in ADP O
+the DET O
+Hengduan PROPN O
+Mountain PROPN O
+Hotspot PROPN O
+, PUNCT O
+was AUX O
+at ADP O
+a DET O
+relatively ADV O
+lower ADJ O
+risk NOUN O
+. PUNCT O
+
+DAA NOUN B-AC
+, PUNCT O
+direct ADJ B-LF
+anterior ADJ I-LF
+approach NOUN I-LF
+; PUNCT O
+CAs PROPN B-AC
+, PUNCT O
+conventional ADJ B-LF
+approaches NOUN I-LF
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+; PUNCT O
+MD NOUN B-AC
+, PUNCT O
+mean NOUN B-LF
+difference NOUN I-LF
+; PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+. PUNCT O
+
+The DET O
+activities NOUN O
+of ADP O
+antioxidant ADJ O
+enzymes NOUN O
+ascorbate NOUN B-LF
+peroxidase NOUN I-LF
+( PUNCT O
+APX PROPN B-AC
+) PUNCT O
+, PUNCT O
+guaiacol NOUN B-LF
+peroxidase NOUN I-LF
+( PUNCT O
+GaPX NOUN B-AC
+) PUNCT O
+, PUNCT O
+catalases NOUN B-LF
+( PUNCT O
+CAT NOUN B-AC
+) PUNCT O
+and CCONJ O
+polyphenol NOUN B-LF
+oxidases NOUN I-LF
+( PUNCT O
+PPO NOUN B-AC
+) PUNCT O
+were AUX O
+measured VERB O
+as ADP O
+parameters NOUN O
+of ADP O
+antioxidant ADJ O
+defence NOUN O
+. PUNCT O
+
+For ADP O
+calculations NOUN O
+of ADP O
+total ADJ O
+effectiveness NOUN O
+among ADP O
+vaccinees NOUN O
+, PUNCT O
+both PRON O
+a DET O
+mITT PROPN B-AC
+approach NOUN O
+and CCONJ O
+an DET O
+according VERB B-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+protocol NOUN I-LF
+( PUNCT O
+ATP PROPN B-AC
+) PUNCT O
+approach NOUN O
+were AUX O
+used VERB O
+. PUNCT O
+
+Values NOUN O
+for ADP O
+graphs NOUN O
+( PUNCT O
+B NOUN O
+) PUNCT O
+and CCONJ O
+( PUNCT O
+C NOUN O
+) PUNCT O
+are AUX O
+listed VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+ccd PROPN O
+, PUNCT O
+carotenoid NOUN O
+cleavage NOUN O
+dioxygenase NOUN O
+; PUNCT O
+d14 NOUN O
+, PUNCT O
+dwarf NOUN O
+14 NUM O
+; PUNCT O
+EV PROPN B-AC
+, PUNCT O
+empty ADJ B-LF
+vector NOUN I-LF
+; PUNCT O
+IAA PROPN B-AC
+, PUNCT O
+indole-3 NOUN B-LF
+- PUNCT I-LF
+acetic ADJ I-LF
+acid NOUN I-LF
+; PUNCT O
+JA PROPN O
+, PUNCT O
+jasmonate NOUN O
+; PUNCT O
+JA PROPN B-AC
+- PUNCT B-AC
+Ile PROPN B-AC
+, PUNCT O
+jasmonic ADJ B-LF
+acid NOUN I-LF
+- PUNCT I-LF
+isoleucine NOUN I-LF
+; PUNCT O
+kai2 PROPN O
+, PUNCT O
+karrikin NOUN O
+insensitive ADJ O
+2 NUM O
+; PUNCT O
+max2 NOUN O
+, PUNCT O
+more ADJ O
+axillary ADJ O
+growth NOUN O
+2 NUM O
+; PUNCT O
+n.s PROPN O
+. PUNCT O
+not PART O
+significant ADJ O
+. PUNCT O
+
+GFAP PROPN B-AC
+, PUNCT O
+a DET O
+type NOUN O
+III NUM O
+intermediate ADJ B-LF
+filament NOUN I-LF
+( PUNCT O
+IF PROPN B-AC
+) PUNCT O
+protein NOUN O
+responsible ADJ O
+for ADP O
+the DET O
+cytoskeletal ADJ O
+structure NOUN O
+of ADP O
+glial ADJ O
+cells NOUN O
+, PUNCT O
+is AUX O
+critical ADJ O
+in ADP O
+maintaining VERB O
+the DET O
+IF PROPN B-AC
+network NOUN O
+of ADP O
+activated ADJ O
+astrocytes NOUN O
+, PUNCT O
+with ADP O
+processes NOUN O
+that PRON O
+develop VERB O
+thickened ADJ O
+and CCONJ O
+elongated ADJ O
+shapes NOUN O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+
+Briefly ADV O
+, PUNCT O
+in ADP O
+three NUM O
+separate ADJ O
+trials NOUN O
+, PUNCT O
+using VERB O
+two NUM O
+- ADJ O
+fold ADJ O
+dilutions NOUN O
+, PUNCT O
+different ADJ O
+concentrations NOUN O
+of ADP O
+HYD PROPN B-AC
+, PUNCT O
+DFMO PROPN B-AC
+, PUNCT O
+DA PROPN B-AC
+, PUNCT O
+CLF PROPN B-AC
+, PUNCT O
+and CCONJ O
+ATV PROPN B-AC
+were AUX O
+prepared VERB O
+in ADP O
+the DET O
+culture NOUN O
+medium NOUN O
+and CCONJ O
+added VERB O
+in ADP O
+96 NUM O
+- ADJ O
+well NOUN O
+plates NOUN O
+in ADP O
+triplicate NOUN O
+with ADP O
+1 NUM O
+% NOUN O
+parasitemia NOUN O
+for ADP O
+T. PROPN O
+equi PROPN O
+, PUNCT O
+B. PROPN O
+caballi PROPN O
+and CCONJ O
+B. PROPN O
+divergens PROPN O
+at ADP O
+5 NUM O
+% NOUN O
+hematocrit NOUN B-LF
+( PUNCT O
+HCT PROPN B-AC
+) PUNCT O
+while SCONJ O
+for ADP O
+B. PROPN O
+bigemina NOUN O
+and CCONJ O
+B. PROPN O
+bovis NOUN O
+using VERB O
+2.5 NUM O
+% NOUN O
+HCT PROPN B-AC
+. PUNCT O
+Afterward ADV O
+, PUNCT O
+parasite NOUN O
+cultures NOUN O
+were AUX O
+incubated VERB O
+for ADP O
+4 NUM O
+consecutive ADJ O
+days NOUN O
+without ADP O
+changing VERB O
+medium NOUN O
+at ADP O
+37 NUM O
+° NOUN O
+C NOUN O
+humidified VERB O
+multi ADJ O
+- ADJ O
+gas ADJ O
+incubator NOUN O
+in ADP O
+5 NUM O
+% NOUN O
+CO2 NOUN O
+, PUNCT O
+5 NUM O
+% NOUN O
+O2 NOUN O
+, PUNCT O
+and CCONJ O
+90 NUM O
+% NOUN O
+N2 NOUN O
+atmosphere NOUN O
+. PUNCT O
+
+Cells NOUN O
+were AUX O
+then ADV O
+washed VERB O
+in ADP O
+1× NUM O
+Perm PROPN O
+/ SYM O
+Wash PROPN O
+buffer NOUN O
+( PUNCT O
+BD PROPN O
+Pharmingen PROPN O
+) PUNCT O
+and CCONJ O
+stained VERB O
+with ADP O
+interferon NOUN B-LF
+gamma NOUN I-LF
+( PUNCT O
+IFN PROPN B-AC
+- PUNCT B-AC
+γ)-allophycocyanin NOUN O
+or CCONJ O
+tumor NOUN B-LF
+necrosis NOUN I-LF
+factor NOUN I-LF
+alpha NOUN I-LF
+( PUNCT O
+TNF PROPN B-AC
+- PUNCT B-AC
+α)-allophycocyanin NOUN O
+in ADP O
+1× NUM O
+Perm PROPN O
+/ SYM O
+Wash PROPN O
+buffer NOUN O
+for ADP O
+45 NUM O
+min NOUN O
+at ADP O
+4 NUM O
+° NOUN O
+C NOUN O
+in ADP O
+the DET O
+dark NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+ARI PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+respiratory ADJ I-LF
+infection NOUN I-LF
+; PUNCT O
+CHW PROPN B-AC
+, PUNCT O
+community NOUN B-LF
+health NOUN I-LF
+worker NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+DHS PROPN B-AC
+, PUNCT O
+Demographic PROPN B-LF
+and CCONJ I-LF
+Health PROPN I-LF
+Survey PROPN I-LF
+; PUNCT O
+GEE PROPN B-AC
+, PUNCT O
+generalized ADJ B-LF
+estimating NOUN I-LF
+equation NOUN I-LF
+; PUNCT O
+IMCI PROPN B-AC
+, PUNCT O
+Integrated PROPN B-LF
+Management PROPN I-LF
+of ADP I-LF
+Childhood PROPN I-LF
+Illness PROPN I-LF
+; PUNCT O
+PR PROPN B-AC
+, PUNCT O
+prevalance NOUN O
+ratio NOUN O
+. PUNCT O
+
+Glycerophosphodiesterase NOUN B-LF
+5 NUM I-LF
+( PUNCT O
+GDE5 PROPN B-AC
+) PUNCT O
+selectively ADV O
+hydrolyses VERB O
+glycerophosphocholine NOUN O
+to ADP O
+choline NOUN O
+and CCONJ O
+is AUX O
+highly ADV O
+expressed VERB O
+in ADP O
+type NOUN O
+II NUM O
+fiber NOUN O
+- PUNCT O
+rich ADJ O
+skeletal ADJ O
+muscles NOUN O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+M NOUN O
+, PUNCT O
+number NOUN O
+of ADP O
+occurrences NOUN O
+of ADP O
+adverse ADJ O
+events NOUN O
+; PUNCT O
+NA PROPN B-AC
+, PUNCT O
+not PART B-LF
+applicable ADJ I-LF
+
+MPAP PROPN B-AC
+was AUX O
+estimated VERB O
+as SCONJ O
+the DET O
+mean ADJ O
+systolic ADJ O
+right ADJ O
+ventricle NOUN O
+– PUNCT O
+to ADP O
+– PUNCT O
+right ADJ O
+atrium NOUN O
+pressure NOUN O
+gradient NOUN O
+by ADP O
+tracing VERB O
+the DET O
+TR NOUN B-AC
+time NOUN B-LF
+- PUNCT I-LF
+velocity NOUN I-LF
+integral NOUN I-LF
+( PUNCT O
+VTI PROPN B-AC
+) PUNCT O
+as SCONJ O
+previously ADV O
+validated VERB O
+[ X O
+11,20 NUM O
+] PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+ACE PROPN B-AC
+- PUNCT B-AC
+I PROPN B-AC
+, PUNCT O
+angiotensin NOUN B-LF
+- PUNCT I-LF
+converting VERB I-LF
+enzyme NOUN I-LF
+inhibitor NOUN I-LF
+; PUNCT O
+HR PROPN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+PY PROPN O
+, PUNCT O
+person NOUN O
+- PUNCT O
+year NOUN O
+. PUNCT O
+
+The DET O
+diffusing VERB B-LF
+capacity NOUN I-LF
+of ADP I-LF
+the DET I-LF
+lungs NOUN I-LF
+for ADP I-LF
+carbon NOUN I-LF
+monoxide NOUN I-LF
+( PUNCT O
+DLCO PROPN B-AC
+) PUNCT O
+was AUX O
+significantly ADV O
+lower ADJ O
+in ADP O
+the DET O
+LC PROPN B-AC
+with ADP O
+IPF PROPN B-AC
+group NOUN O
+than ADP O
+in ADP O
+the DET O
+LC PROPN B-AC
+without ADP O
+IPF PROPN B-AC
+group NOUN O
+( PUNCT O
+83.7±20.8 NUM O
+vs. ADP O
+104.3±24.7 NUM O
+; PUNCT O
+P<0.001 NUM O
+) PUNCT O
+. PUNCT O
+
+IPV NOUN B-AC
+, PUNCT O
+intimate ADJ B-LF
+partner NOUN I-LF
+violence NOUN I-LF
+. PUNCT O
+
+Those DET O
+situations NOUN O
+were AUX O
+categorized VERB O
+as ADP O
+significant ADJ O
+public ADJ O
+health NOUN O
+problems NOUN O
+based VERB O
+on ADP O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+criteria NOUN O
+. PUNCT O
+
+MI ADJ B-AC
+provokes VERB O
+a DET O
+profound ADJ O
+coordinated ADJ O
+inflammatory ADJ O
+response NOUN O
+, PUNCT O
+a DET O
+process NOUN O
+mediated VERB O
+by ADP O
+inflammatory ADJ O
+bone NOUN B-LF
+marrow NOUN I-LF
+( PUNCT O
+BM NOUN B-AC
+) PUNCT O
+and CCONJ O
+peripheral ADJ B-LF
+blood NOUN I-LF
+( PUNCT O
+PB NOUN B-AC
+) PUNCT O
+cells NOUN O
+, PUNCT O
+which PRON O
+has AUX O
+been AUX O
+linked VERB O
+to ADP O
+the DET O
+development NOUN O
+of ADP O
+end NOUN O
+stage NOUN O
+heart NOUN B-LF
+failure NOUN I-LF
+( PUNCT O
+HF NOUN B-AC
+) PUNCT O
+, PUNCT O
+a DET O
+highly ADV O
+frequent ADJ O
+complication NOUN O
+post X O
+- ADJ O
+MI ADJ B-AC
+[ X O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+physical ADJ O
+abuse NOUN O
+, PUNCT O
+significant ADJ O
+associations NOUN O
+were AUX O
+also ADV O
+observed VERB O
+with ADP O
+post ADJ B-LF
+- ADJ I-LF
+traumatic ADJ I-LF
+stress NOUN I-LF
+disorder NOUN I-LF
+( PUNCT O
+PTSD PROPN B-AC
+) PUNCT O
+and CCONJ O
+panic NOUN O
+disorder NOUN O
+diagnoses NOUN O
+( PUNCT O
+Table NOUN O
+S2 NUM O
+) PUNCT O
+. PUNCT O
+
+It PRON O
+has VERB O
+been AUX O
+shown VERB O
+that SCONJ O
+male NOUN B-LF
+involvement NOUN I-LF
+( PUNCT O
+MI PROPN B-AC
+) PUNCT O
+in ADP O
+ANC PROPN B-AC
+and CCONJ O
+PMTCT PROPN B-AC
+can AUX O
+increase VERB O
+adherence NOUN O
+to PART O
+PMTCT PROPN B-AC
+strategies NOUN O
+, PUNCT O
+and CCONJ O
+thus ADV O
+has VERB O
+positive ADJ O
+effects NOUN O
+on ADP O
+rates NOUN O
+of ADP O
+MTCT PROPN B-AC
+and CCONJ O
+infant NOUN O
+survival NOUN O
+[ PUNCT O
+9 NUM O
+, PUNCT O
+28 NUM O
+, PUNCT O
+29 NUM O
+] PUNCT O
+, PUNCT O
+however ADV O
+, PUNCT O
+the DET O
+success NOUN O
+of ADP O
+implementing VERB O
+programs NOUN O
+aiming VERB O
+to PART O
+improve VERB O
+MI PROPN B-AC
+seems VERB O
+to PART O
+vary VERB O
+in ADP O
+different ADJ O
+contexts NOUN O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+. PUNCT O
+
+Using VERB O
+an DET O
+internal ADJ O
+validation NOUN O
+set NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+1,993 NUM O
+) PUNCT O
+, PUNCT O
+we PRON O
+selected VERB O
+the DET O
+2 NUM O
+top ADV O
+- PUNCT O
+performing VERB O
+models NOUN O
+; PUNCT O
+these DET O
+models NOUN O
+were AUX O
+then ADV O
+evaluated VERB O
+on ADP O
+a DET O
+held VERB O
+- PUNCT O
+out ADP O
+internal ADJ O
+test NOUN O
+set NOUN O
+based VERB O
+on ADP O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+receiver NOUN I-LF
+operating NOUN I-LF
+characteristic NOUN I-LF
+curve NOUN I-LF
+( PUNCT O
+AUC PROPN B-AC
+) PUNCT O
+, PUNCT O
+sensitivity NOUN O
+, PUNCT O
+specificity NOUN O
+, PUNCT O
+and CCONJ O
+positive ADJ B-LF
+predictive ADJ I-LF
+value NOUN I-LF
+( PUNCT O
+PPV NOUN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+final ADJ O
+internal ADJ O
+test NOUN O
+was AUX O
+performed VERB O
+initially ADV O
+on ADP O
+a DET O
+subset NOUN O
+with SCONJ O
+small ADJ O
+pneumothorax NOUN O
+excluded VERB O
+( PUNCT O
+as ADP O
+in ADP O
+training NOUN O
+; PUNCT O
+n NOUN O
+= SYM O
+1,701 NUM O
+) PUNCT O
+, PUNCT O
+then ADV O
+on ADP O
+the DET O
+full ADJ O
+test NOUN O
+set NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+1,990 NUM O
+) PUNCT O
+, PUNCT O
+with SCONJ O
+small ADJ O
+pneumothorax NOUN O
+included VERB O
+as ADP O
+positive ADJ O
+. PUNCT O
+
+Key ADJ O
+drug NOUN O
+resistance NOUN O
+mutations NOUN O
+were AUX O
+defined VERB O
+as ADP O
+those PRON O
+listed VERB O
+by ADP O
+the DET O
+International PROPN B-LF
+AIDS PROPN I-LF
+Society PROPN I-LF
+- PUNCT I-LF
+USA PROPN I-LF
+( PUNCT O
+IAS PROPN B-AC
+- PUNCT B-AC
+USA PROPN B-AC
+) PUNCT O
+Drug PROPN O
+Resistance PROPN O
+Mutations PROPN O
+Group PROPN O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+performed VERB O
+a DET O
+GWAS NOUN B-AC
+to PART O
+identify VERB O
+genetic ADJ O
+loci NOUN O
+influencing VERB O
+liver NOUN O
+function NOUN O
+, PUNCT O
+as SCONJ O
+measured VERB O
+by ADP O
+concentrations NOUN O
+of ADP O
+alkaline ADJ B-LF
+phosphatase NOUN I-LF
+( PUNCT O
+ALP PROPN B-AC
+) PUNCT O
+, PUNCT O
+alanine NOUN O
+transaminase NOUN O
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+, PUNCT O
+gamma NOUN B-LF
+- PUNCT I-LF
+glutamyl NOUN I-LF
+transferase NOUN I-LF
+( PUNCT O
+GGT PROPN B-AC
+) PUNCT O
+and CCONJ O
+total ADJ B-LF
+bilirubin NOUN I-LF
+( PUNCT O
+BIL NOUN B-AC
+) PUNCT O
+in ADP O
+in ADP O
+Korean ADJ O
+study NOUN O
+participants NOUN O
+. PUNCT O
+
+In ADP O
+- PUNCT O
+hospital NOUN O
+mortality NOUN O
+was AUX O
+recorded VERB O
+among ADP O
+24.5 NUM O
+% NOUN O
+, PUNCT O
+where SCONJ O
+67.5 NUM O
+% NOUN O
+of ADP O
+them PRON O
+had VERB O
+diagnosis NOUN O
+of ADP O
+STEMI PROPN B-AC
+. PUNCT O
+Very ADV O
+few ADJ O
+( PUNCT O
+3.9 NUM O
+% NOUN O
+) PUNCT O
+patients NOUN O
+were AUX O
+referred VERB O
+for ADP O
+surgical ADJ O
+intervention NOUN O
+of ADP O
+coronary ADJ B-LF
+artery NOUN I-LF
+bypass NOUN I-LF
+grafting NOUN I-LF
+( PUNCT O
+CABG PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+most ADV O
+common ADJ O
+ACS PROPN B-AC
+- PUNCT O
+related VERB O
+complication NOUN O
+was AUX O
+heart NOUN O
+failure NOUN O
+which PRON O
+was AUX O
+observed VERB O
+in ADP O
+about ADV O
+42.4 NUM O
+% NOUN O
+of ADP O
+the DET O
+patients NOUN O
+. PUNCT O
+
+ApoA1 PROPN O
+= VERB O
+apolipoprotein NOUN O
+A1 NUM O
+; PUNCT O
+CI NOUN B-AC
+= VERB O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+Known ADJ O
+CAD NOUN B-AC
+= VERB O
+previously ADV O
+known VERB O
+coronary ADJ B-LF
+artery NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+SBP PROPN B-AC
+= VERB O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+. PUNCT O
+
+Lower ADJ O
+panel NOUN O
+: PUNCT O
+primers NOUN O
+and CCONJ O
+plasmids NOUN O
+for ADP O
+allelic ADJ O
+exchange NOUN O
+as ADP O
+well ADV O
+as ADP O
+resulting VERB O
+strains NOUN O
+. PUNCT O
+fliC NOUN B-AC
+, PUNCT O
+flagellin NOUN B-LF
+. PUNCT O
+
+ADAR1 NOUN B-AC
+, PUNCT O
+adenosine NOUN B-LF
+deaminase NOUN I-LF
+acting VERB I-LF
+on ADP I-LF
+RNA NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+ADAR1KO PROPN B-AC
+, PUNCT O
+fully ADV B-LF
+ADAR1 NOUN I-LF
+- PUNCT I-LF
+deficient ADJ I-LF
+; PUNCT O
+Cas9 PROPN B-AC
+, PUNCT O
+CRISPR PROPN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+9 NUM I-LF
+; PUNCT O
+chr1 PROPN O
+, PUNCT O
+human ADJ O
+chromosome NOUN O
+1 NUM O
+; PUNCT O
+CRISPR PROPN B-AC
+, PUNCT O
+clustered VERB B-LF
+regularly ADV I-LF
+interspaced VERB I-LF
+short ADJ I-LF
+palindromic ADJ I-LF
+repeat NOUN I-LF
+; PUNCT O
+gRNA NOUN O
+, PUNCT O
+guide NOUN O
+RNA NOUN O
+; PUNCT O
+IFN PROPN B-AC
+, PUNCT O
+interferon NOUN B-LF
+; PUNCT O
+IFN PROPN B-AC
+A PROPN B-AC
+/ SYM B-AC
+D PROPN B-AC
+, PUNCT O
+recombinant ADJ B-LF
+type NOUN I-LF
+- PUNCT I-LF
+I NOUN I-LF
+IFN PROPN I-LF
+- PUNCT I-LF
+alpha NOUN I-LF
+; PUNCT O
+p150KO PROPN B-AC
+, PUNCT O
+selectively ADV B-LF
+ADAR1p150 NOUN I-LF
+- PUNCT I-LF
+deficient ADJ I-LF
+; PUNCT O
+PAM PROPN O
+, PUNCT O
+protospacer NOUN O
+adjacent ADJ O
+motif NOUN O
+. PUNCT O
+
+Because SCONJ O
+voluminous ADJ O
+epicardial ADJ O
+adipose ADJ O
+tissue NOUN O
+is AUX O
+a DET O
+risk NOUN O
+factor NOUN O
+for ADP O
+coronary ADJ O
+events NOUN O
+, PUNCT O
+there PRON O
+is AUX O
+a DET O
+possibility NOUN O
+that SCONJ O
+the DET O
+pericoronary ADJ B-LF
+adipose ADJ I-LF
+tissue NOUN I-LF
+( PUNCT O
+PCAT PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+a DET O
+part NOUN O
+of ADP O
+epicardial ADJ O
+adipose ADJ O
+tissue NOUN O
+, PUNCT O
+acts VERB O
+as ADP O
+a DET O
+risk NOUN O
+factor NOUN O
+by ADP O
+supplying VERB O
+oxLDL NOUN B-AC
+to ADP O
+the DET O
+coronary ADJ O
+arterial ADJ O
+wall NOUN O
+. PUNCT O
+
+URI NOUN B-AC
+: PUNCT O
+Upper ADJ B-LF
+respiratory ADJ I-LF
+infection NOUN I-LF
+
+Purified VERB O
+recombinant ADJ O
+PDO PROPN B-AC
+from ADP O
+P. PROPN O
+aerophilum PROPN O
+( PUNCT O
+PaPDO PROPN B-AC
+) PUNCT O
+was AUX O
+reacted VERB O
+with ADP O
+the DET O
+fluorescent ADJ O
+thiol NOUN O
+- PUNCT O
+reactive ADJ O
+label NOUN O
+7 NUM B-LF
+- PUNCT I-LF
+diethylamino-3-(4′-maleimidylphenyl)-4 NOUN I-LF
+- PUNCT I-LF
+methylcoumarin NOUN I-LF
+( PUNCT O
+CPM PROPN B-AC
+) PUNCT O
+under ADP O
+denaturing VERB O
+conditions NOUN O
+in ADP O
+the DET O
+presence NOUN O
+or CCONJ O
+absence NOUN O
+of ADP O
+the DET O
+reductant ADJ O
+tris(2 NOUN B-LF
+- PUNCT I-LF
+carboxyethyl)phosphine NOUN I-LF
+hydrochloride NOUN I-LF
+( PUNCT O
+TCEP PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+denaturing VERB O
+conditions NOUN O
+ensure VERB O
+that SCONJ O
+all DET O
+cysteines NOUN O
+are AUX O
+accessible ADJ O
+to ADP O
+the DET O
+modifying VERB O
+reagent NOUN O
+. PUNCT O
+
+It PRON O
+has AUX O
+been AUX O
+well ADV O
+known VERB O
+that SCONJ O
+the DET O
+Protein PROPN B-LF
+Kinase PROPN I-LF
+C PROPN I-LF
+( PUNCT O
+PKC PROPN B-AC
+) PUNCT O
+can AUX O
+regulate VERB O
+the DET O
+PI3K NOUN B-AC
+/ SYM O
+AKT NOUN O
+pathway NOUN O
+both CCONJ O
+positively ADV O
+[ X O
+7 NUM O
+] PUNCT O
+and CCONJ O
+negatively ADV O
+[ X O
+8 NUM O
+] PUNCT O
+, PUNCT O
+depending VERB O
+on ADP O
+the DET O
+isoform NOUN O
+. PUNCT O
+
+The DET O
+Edinburgh PROPN O
+Mouse PROPN O
+Atlas PROPN O
+Project PROPN O
+also ADV O
+provides VERB O
+tools NOUN O
+to PART O
+map VERB O
+in ADP B-LF
+situ NOUN I-LF
+hybridization NOUN I-LF
+( PUNCT O
+ISH NOUN B-AC
+) PUNCT O
+images NOUN O
+directly ADV O
+into ADP O
+a DET O
+three NUM B-LF
+- ADJ I-LF
+dimensional ADJ I-LF
+( PUNCT O
+3D ADJ B-AC
+) PUNCT O
+atlas NOUN O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+yield NOUN O
+of ADP O
+cervical ADJ B-LF
+intraepithelial ADJ I-LF
+neoplasia NOUN I-LF
+grade NOUN I-LF
+3 NUM I-LF
+( PUNCT O
+CIN3 NOUN B-AC
+) PUNCT O
+was AUX O
+the DET O
+same ADJ O
+between ADP O
+arms NOUN O
+( PUNCT O
+Table NOUN O
+5 NUM O
+) PUNCT O
+. PUNCT O
+
+BSS PROPN B-AC
+: PUNCT O
+Bristol PROPN B-LF
+stool NOUN I-LF
+scale NOUN I-LF
+; PUNCT O
+IQR PROPN O
+: PUNCT O
+interquartile ADJ O
+range NOUN O
+. PUNCT O
+
+To ADP O
+this DET O
+end NOUN O
+, PUNCT O
+we PRON O
+crossed VERB O
+mTor PROPN O
+and CCONJ O
+regulatory ADJ B-LF
+associated VERB I-LF
+protein NOUN I-LF
+of ADP I-LF
+MTORc1 PROPN I-LF
+( PUNCT O
+Rptor PROPN B-AC
+) PUNCT O
+floxed ADJ O
+mouse NOUN O
+strains NOUN O
+onto ADP O
+Tsc1 PROPN O
+floxed ADJ O
+: PUNCT O
+Cd11c PROPN O
+- PUNCT O
+Cre PROPN B-AC
+mice NOUN O
+, PUNCT O
+thereby ADV O
+generating VERB O
+TSC1 PROPN B-AC
+/ SYM O
+mTORDC PROPN O
+- PUNCT O
+DKO PROPN O
+and CCONJ O
+TSC1 PROPN B-AC
+/ SYM O
+RaptorDC PROPN O
+- PUNCT O
+DKO PROPN O
+mice NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+Commercially ADV O
+available ADJ O
+Enzyme PROPN B-LF
+- PUNCT I-LF
+Linked PROPN I-LF
+ImmunoSorbent PROPN I-LF
+Assays NOUN I-LF
+( PUNCT O
+ELISAs PROPN B-AC
+) PUNCT O
+were AUX O
+used VERB O
+to PART O
+measure VERB O
+the DET O
+concentration NOUN O
+of ADP O
+CSF PROPN B-AC
+APP PROPN B-AC
+, PUNCT O
+NCAM-1 PROPN B-AC
+, PUNCT O
+L1CAM PROPN B-AC
+. PUNCT O
+Sandwich PROPN O
+Duoset PROPN O
+ELISA PROPN B-AC
+development NOUN O
+systems NOUN O
+( PUNCT O
+R&D PROPN O
+Systems PROPN O
+, PUNCT O
+catalog NOUN O
+# NOUN O
+DY-850 NOUN O
+, PUNCT O
+and CCONJ O
+DY-2408 PROPN O
+respectively ADV O
+; PUNCT O
+Minneapolis PROPN O
+, PUNCT O
+MN PROPN O
+) PUNCT O
+were AUX O
+used VERB O
+to PART O
+measure VERB O
+APP PROPN B-AC
+and CCONJ O
+NCAM-1 PROPN B-AC
+as SCONJ O
+previously ADV O
+described VERB O
+[ PUNCT O
+28 NUM O
+] PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+CCHHS PROPN B-AC
+, PUNCT O
+Cook PROPN B-LF
+County PROPN I-LF
+Health PROPN I-LF
+& CCONJ I-LF
+Hospitals PROPN I-LF
+System PROPN I-LF
+; PUNCT O
+CTL PROPN B-AC
+, PUNCT O
+Clinical PROPN B-LF
+Transition PROPN I-LF
+Liaison PROPN I-LF
+; PUNCT O
+FQHC PROPN B-AC
+, PUNCT O
+federally ADV B-LF
+qualified ADJ I-LF
+health NOUN I-LF
+center NOUN I-LF
+; PUNCT O
+PLWH PROPN B-AC
+, PUNCT O
+people NOUN B-LF
+living VERB I-LF
+with ADP I-LF
+HIV PROPN I-LF
+; PUNCT O
+SHRT PROPN B-AC
+, PUNCT O
+Special PROPN B-LF
+Health PROPN I-LF
+Resources PROPN I-LF
+for ADP I-LF
+Texas PROPN I-LF
+; PUNCT O
+UPMC PROPN B-AC
+, PUNCT O
+University PROPN B-LF
+of ADP I-LF
+Pittsburgh PROPN I-LF
+Medical PROPN I-LF
+Center PROPN I-LF
+. PUNCT O
+
+The DET O
+Tyramide PROPN B-LF
+Signal PROPN I-LF
+Amplification PROPN I-LF
+( PUNCT O
+TSA PROPN B-AC
+) PUNCT O
+kit NOUN O
+( PUNCT O
+Molecular ADJ O
+probes NOUN O
+) PUNCT O
+was AUX O
+used VERB O
+to PART O
+detect VERB O
+HRP NOUN B-AC
+activity NOUN O
+as ADP O
+per ADP O
+manufacturer NOUN O
+’s PART O
+instructions NOUN O
+. PUNCT O
+
+Epstein PROPN B-LF
+– PUNCT I-LF
+Barr PROPN I-LF
+virus NOUN I-LF
+( PUNCT O
+EBV PROPN B-AC
+) PUNCT O
+provides VERB O
+a DET O
+good ADJ O
+candidate NOUN O
+to PART O
+address VERB O
+these DET O
+issues NOUN O
+. PUNCT O
+
+The DET O
+2013 NUM O
+Global PROPN B-LF
+Burden PROPN I-LF
+of ADP I-LF
+Disease PROPN I-LF
+( PUNCT O
+GBD PROPN B-AC
+2013 NUM O
+) PUNCT O
+estimated VERB O
+DALYs NOUN B-AC
+for ADP O
+a DET O
+number NOUN O
+of ADP O
+syndromes NOUN O
+other ADJ O
+than ADP O
+HAIs PROPN B-AC
+[ PUNCT O
+28 NUM O
+] PUNCT O
+. PUNCT O
+
+COR PROPN B-AC
+, PUNCT O
+crude ADJ B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+AOR PROPN B-AC
+, PUNCT O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+CI PROPN O
+, PUNCT O
+confidence NOUN O
+interval NOUN O
+
+We PRON O
+also ADV O
+evaluated VERB O
+group NOUN O
+differences NOUN O
+, PUNCT O
+defined VERB O
+as ADP O
+the DET O
+differences NOUN O
+in ADP O
+Δchanges NOUN O
+in ADP O
+the DET O
+Mediterranean ADJ O
+group NOUN O
+compared VERB O
+with ADP O
+Δchanges NOUN O
+in ADP O
+the DET O
+low ADJ O
+- PUNCT O
+fat NOUN O
+group NOUN O
+, PUNCT O
+which PRON O
+included VERB O
+the DET O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+CS PROPN B-AC
+, PUNCT O
+complex ADJ B-LF
+spikes NOUN I-LF
+; PUNCT O
+MI PROPN B-AC
+, PUNCT O
+mutual ADJ B-LF
+information NOUN I-LF
+; PUNCT O
+SDF PROPN B-AC
+, PUNCT O
+spike NOUN B-LF
+density NOUN I-LF
+function NOUN I-LF
+. PUNCT O
+
+Previous ADJ O
+resting ADJ O
+- PUNCT O
+state NOUN O
+functional ADJ B-LF
+MRI NOUN I-LF
+( PUNCT O
+fMRI NOUN B-AC
+) PUNCT O
+studies NOUN O
+that PRON O
+have AUX O
+focused VERB O
+on ADP O
+time NOUN O
+of ADP O
+day NOUN O
+have AUX O
+yielded VERB O
+inconsistent ADJ O
+results NOUN O
+, PUNCT O
+potentially ADV O
+because SCONJ O
+of ADP O
+small ADJ O
+sample NOUN O
+sizes NOUN O
+[ PUNCT O
+14,19–23 NUM O
+] PUNCT O
+. PUNCT O
+
+Sex NOUN O
+determination NOUN O
+in ADP O
+mammals NOUN O
+is AUX O
+controlled VERB O
+by ADP O
+the DET O
+presence NOUN O
+or CCONJ O
+absence NOUN O
+of ADP O
+the DET O
+Y PROPN O
+- PUNCT O
+linked VERB O
+gene NOUN O
+SRY PROPN B-AC
+. PUNCT O
+In ADP O
+the DET O
+developing VERB O
+male NOUN O
+( PUNCT O
+XY PROPN O
+) PUNCT O
+gonad NOUN O
+, PUNCT O
+sex NOUN B-LF
+- PUNCT I-LF
+determining VERB I-LF
+region NOUN I-LF
+of ADP I-LF
+the DET I-LF
+Y PROPN I-LF
+( PUNCT O
+SRY PROPN B-AC
+) PUNCT O
+protein NOUN O
+acts VERB O
+to PART O
+up ADV O
+- PUNCT O
+regulate VERB O
+expression NOUN O
+of ADP O
+the DET O
+related ADJ O
+gene NOUN O
+, PUNCT O
+SOX9 PROPN O
+, PUNCT O
+a DET O
+transcriptional ADJ O
+regulator NOUN O
+that PRON O
+in ADP O
+turn NOUN O
+initiates VERB O
+a DET O
+downstream ADJ O
+pathway NOUN O
+of ADP O
+testis NOUN O
+development NOUN O
+, PUNCT O
+whilst SCONJ O
+also ADV O
+suppressing VERB O
+ovary ADJ O
+development NOUN O
+. PUNCT O
+
+MEDLINE PROPN O
+, PUNCT O
+Web PROPN O
+of ADP O
+Science PROPN O
+, PUNCT O
+Embase PROPN O
+, PUNCT O
+and CCONJ O
+Cochrane PROPN O
+Data PROPN O
+of ADP O
+Systematic PROPN O
+Reviews PROPN O
+were AUX O
+searched VERB O
+in ADP O
+accordance NOUN O
+with ADP O
+the DET O
+Preferred PROPN B-LF
+Reporting PROPN I-LF
+Items PROPN I-LF
+for ADP I-LF
+Systematic PROPN I-LF
+Reviews PROPN I-LF
+and CCONJ I-LF
+Meta PROPN I-LF
+- PROPN I-LF
+Analyses PROPN I-LF
+( PUNCT O
+PRISMA PROPN B-AC
+) PUNCT O
+statement NOUN O
+( PUNCT O
+S1 PROPN O
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+
+PMMA NOUN B-AC
+= PUNCT O
+polymethyl ADJ B-LF
+methacrylate NOUN I-LF
+, PUNCT O
+SD NOUN B-AC
+= PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+. PUNCT O
+
+aHR NOUN O
+, PUNCT O
+adjusted ADJ O
+hazard NOUN O
+ratio NOUN O
+; PUNCT O
+cHR PROPN O
+, PUNCT O
+crude ADJ O
+hazard NOUN O
+ratio NOUN O
+; PUNCT O
+CVD NOUN B-AC
+, PUNCT O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+; PUNCT O
+HELLP PROPN B-AC
+, PUNCT O
+hemolysis NOUN B-LF
+, PUNCT I-LF
+elevated ADJ I-LF
+liver NOUN I-LF
+enzymes NOUN I-LF
+, PUNCT I-LF
+and CCONJ I-LF
+low ADJ I-LF
+platelet NOUN I-LF
+. PUNCT O
+
+Another DET O
+study NOUN O
+with ADP O
+Madin PROPN B-LF
+- PUNCT I-LF
+Darby PROPN I-LF
+canine ADJ I-LF
+kidney NOUN I-LF
+II NUM I-LF
+cells NOUN I-LF
+overexpressing VERB O
+bABCG2 NOUN B-AC
+( PUNCT O
+MDCKII PROPN B-AC
+- PUNCT O
+bABCG2 NOUN B-AC
+) PUNCT O
+also ADV O
+demonstrated VERB O
+a DET O
+TCDD- NOUN B-AC
+and CCONJ O
+prochloraz NOUN O
+- PUNCT O
+mediated VERB O
+activation NOUN O
+of ADP O
+AhR PROPN B-AC
+induced VERB O
+bABCG2 NOUN B-AC
+mRNA NOUN O
+expression NOUN O
+and CCONJ O
+efflux NOUN O
+activity NOUN O
+[ PUNCT O
+29 NUM O
+] PUNCT O
+. PUNCT O
+
+CR PROPN B-AC
+, PUNCT O
+Critically ADV B-LF
+Endangered VERB I-LF
+; PUNCT O
+EN PROPN B-AC
+, PUNCT O
+Endangered VERB B-LF
+; PUNCT O
+LC PROPN B-AC
+, PUNCT O
+Least ADJ B-LF
+Concern NOUN I-LF
+; PUNCT O
+NPA PROPN B-AC
+, PUNCT O
+Non PROPN B-LF
+- PROPN I-LF
+Protected VERB I-LF
+Areas NOUN I-LF
+; PUNCT O
+NT PROPN B-AC
+, PUNCT O
+Near ADV B-LF
+Threatened VERB I-LF
+; PUNCT O
+RA PROPN B-AC
+, PUNCT O
+Restricted VERB B-LF
+Areas NOUN I-LF
+; PUNCT O
+SPA PROPN B-AC
+, PUNCT O
+Strictly ADV B-LF
+Protected VERB I-LF
+Areas NOUN I-LF
+; PUNCT O
+VU PROPN B-AC
+, PUNCT O
+Vulnerable ADJ B-LF
+. PUNCT O
+
+For ADP O
+the DET O
+transcriptional ADJ O
+activation NOUN O
+of ADP O
+anti ADJ B-LF
+- PUNCT I-LF
+oxidant ADJ I-LF
+response NOUN I-LF
+element NOUN I-LF
+( PUNCT O
+ARE PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+pARE PROPN O
+- PUNCT O
+Luc PROPN O
+( PUNCT O
+Promega PROPN O
+, PUNCT O
+Fitchburg PROPN O
+, PUNCT O
+WI PROPN O
+) PUNCT O
+DNA NOUN O
+construct NOUN O
+was AUX O
+employed VERB O
+here ADV O
+. PUNCT O
+
+Similarly ADV O
+, PUNCT O
+genetic ADJ O
+and CCONJ O
+Ab PROPN O
+- ADJ O
+mediated VERB O
+blockade NOUN O
+of ADP O
+IL-10 PROPN B-AC
+signaling NOUN O
+decreases VERB O
+the DET O
+mortality NOUN O
+rate NOUN O
+and CCONJ O
+brain NOUN O
+virus NOUN O
+load NOUN O
+in ADP O
+murine ADJ O
+West PROPN B-LF
+Nile PROPN I-LF
+Virus PROPN I-LF
+( PUNCT O
+WNV)-infection NOUN B-AC
+[ PUNCT O
+31 NUM O
+] PUNCT O
+. PUNCT O
+
+A DET O
+score NOUN O
+significantly ADV O
+higher ADJ O
+than ADP O
+0 NUM O
+indicates VERB O
+a DET O
+neural ADJ O
+pattern NOUN O
+distinct ADJ O
+to ADP O
+that DET O
+memory NOUN O
+is AUX O
+present ADJ O
+in ADP O
+the DET O
+vmPFC PROPN B-AC
+. PUNCT O
+RSA PROPN B-AC
+, PUNCT O
+representational ADJ B-LF
+similarity NOUN I-LF
+analysis NOUN I-LF
+; PUNCT O
+vmPFC PROPN B-AC
+, PUNCT O
+ventromedial ADJ B-LF
+prefrontal ADJ I-LF
+cortex NOUN I-LF
+. PUNCT O
+
+hlh-30 NOUN B-AC
+, PUNCT O
+basic ADJ B-LF
+helix NOUN I-LF
+– PUNCT I-LF
+loop NOUN I-LF
+– PUNCT I-LF
+helix NOUN I-LF
+transcription NOUN I-LF
+factor NOUN I-LF
+30 NUM I-LF
+; PUNCT O
+hlh-30(lf NOUN B-AC
+) PUNCT O
+, PUNCT O
+loss NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+function NOUN O
+tm1978 NOUN B-AC
+mutation NOUN O
+hlh-30 NOUN B-AC
+; PUNCT O
+L1 PROPN B-AC
+, PUNCT O
+first ADJ B-LF
+larval ADJ I-LF
+stage NOUN I-LF
+. PUNCT O
+
+MA PROPN B-AC
+, PUNCT O
+motion NOUN B-LF
+average NOUN I-LF
+; PUNCT O
+SPS PROPN B-AC
+, PUNCT O
+single ADJ B-LF
+pattern NOUN I-LF
+stabilization NOUN I-LF
+; PUNCT O
+TPMP PROPN B-AC
+, PUNCT O
+transparent ADJ B-LF
+panorama NOUN I-LF
+motion NOUN I-LF
+paradigm NOUN I-LF
+; PUNCT O
+YTA PROPN O
+, PUNCT O
+yaw NOUN O
+torque NOUN O
+amplitude NOUN O
+. PUNCT O
+
+Statistical ADJ O
+analyses NOUN O
+were AUX O
+performed VERB O
+using VERB O
+SAS PROPN O
+version NOUN O
+9.2 NUM O
+( PUNCT O
+SAS PROPN O
+Institute PROPN O
+, PUNCT O
+Cary PROPN O
+, PUNCT O
+NC PROPN O
+) PUNCT O
+. PUNCT O
+We PRON O
+used VERB O
+principal ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+PCA PROPN B-AC
+) PUNCT O
+as ADP O
+a DET O
+data NOUN O
+reduction NOUN O
+technique NOUN O
+to PART O
+capture VERB O
+the DET O
+maximum ADJ O
+variation NOUN O
+patterns NOUN O
+in ADP O
+the DET O
+29 NUM O
+cytokine NOUN O
+levels NOUN O
+measured VERB O
+at ADP O
+day NOUN O
+one NUM O
+in ADP O
+few ADJ O
+linearly ADV O
+independent ADJ O
+components.[10 NOUN O
+] PUNCT O
+PCA PROPN B-AC
+summarizes VERB O
+variation NOUN O
+in ADP O
+data NOUN O
+without ADP O
+any DET O
+prior ADJ O
+assumptions NOUN O
+about ADP O
+whether SCONJ O
+the DET O
+samples NOUN O
+come VERB O
+from ADP O
+different ADJ O
+treatment NOUN O
+groups NOUN O
+or CCONJ O
+have VERB O
+phenotypic ADJ O
+differences NOUN O
+, PUNCT O
+thus ADV O
+avoids VERB O
+introducing VERB O
+inherent ADJ O
+bias.[10 NOUN O
+] PUNCT O
+PCA PROPN B-AC
+was AUX O
+carried VERB O
+out ADP O
+on ADP O
+the DET O
+correlation NOUN O
+matrix NOUN O
+of ADP O
+the DET O
+29 NUM O
+cytokine NOUN O
+measures NOUN O
+at ADP O
+baseline NOUN O
+using VERB O
+the DET O
+“ PUNCT O
+PRINCOMP PROPN O
+” PUNCT O
+procedure NOUN O
+of ADP O
+SAS PROPN O
+. PUNCT O
+The DET O
+analysis NOUN O
+generated VERB O
+principal ADJ O
+components NOUN O
+with ADP O
+a DET O
+set NOUN O
+of ADP O
+eigenvalues NOUN O
+and CCONJ O
+eigenvectors NOUN O
+. PUNCT O
+
+ER NOUN B-AC
+, PUNCT O
+endoplasmic ADJ O
+retitculum NOUN O
+; PUNCT O
+SA PROPN B-AC
+, PUNCT O
+spine NOUN B-LF
+apparatus NOUN I-LF
+; PUNCT O
+SERCA PROPN B-AC
+, PUNCT O
+sarco NOUN B-LF
+/ SYM I-LF
+ER NOUN I-LF
+calcium NOUN I-LF
+- PUNCT I-LF
+ATPase NOUN I-LF
+. PUNCT O
+
+DO VERB B-AC
+, PUNCT O
+H2 NOUN O
+- PUNCT O
+O NOUN O
+; PUNCT O
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+MOG PROPN B-AC
+, PUNCT O
+myelin NOUN B-LF
+oligodendrocyte NOUN I-LF
+glycoprotein NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+For ADP O
+the DET O
+case NOUN O
+of ADP O
+coronavirus NOUN B-LF
+disease NOUN I-LF
+2019 NUM I-LF
+( PUNCT O
+COVID-19 NOUN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+presence NOUN O
+of ADP O
+an DET O
+incubation NOUN O
+period NOUN O
+, PUNCT O
+during ADP O
+which PRON O
+infected ADJ O
+individuals NOUN O
+carry VERB O
+on ADP O
+their PRON O
+usual ADJ O
+activities NOUN O
+( PUNCT O
+including VERB O
+travel NOUN O
+) PUNCT O
+, PUNCT O
+was AUX O
+a DET O
+major ADJ O
+challenge NOUN O
+for ADP O
+screening NOUN O
+controls NOUN O
+at ADP O
+airports NOUN O
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+EPO PROPN B-AC
+, PUNCT O
+erythropoietin NOUN B-LF
+; PUNCT O
+FGF23 PROPN B-AC
+, PUNCT O
+fibroblast NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+23 NUM I-LF
+; PUNCT O
+sTfR PROPN B-AC
+, PUNCT O
+soluble ADJ B-LF
+transferrin NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+TSAT PROPN B-AC
+, PUNCT O
+transferrin NOUN B-LF
+saturation NOUN I-LF
+. PUNCT O
+
+Several ADJ O
+studies NOUN O
+suggest VERB O
+that SCONJ O
+migration NOUN O
+is AUX O
+associated VERB O
+with ADP O
+increased VERB O
+hypothalamic ADJ B-LF
+– PUNCT I-LF
+pituitary ADJ I-LF
+– PUNCT I-LF
+adrenal ADJ I-LF
+( PUNCT O
+HPA PROPN B-AC
+) PUNCT O
+axis NOUN O
+function NOUN O
+( PUNCT O
+Meier PROPN O
+and CCONJ O
+Fivizzani PROPN O
+1975 NUM O
+; PUNCT O
+Ramenofsky PROPN O
+et X O
+al X O
+. PUNCT O
+1999 NUM O
+; PUNCT O
+Wingfield PROPN O
+2003 NUM O
+; PUNCT O
+Landys PROPN O
+et X O
+al X O
+. PUNCT O
+2004 NUM O
+) PUNCT O
+. PUNCT O
+
+Diagnostic ADJ O
+imaging NOUN O
+includes VERB O
+the DET O
+use NOUN O
+of ADP O
+conventional ADJ O
+and CCONJ O
+diffusion NOUN O
+- PUNCT O
+based VERB O
+MRI NOUN B-AC
+, PUNCT O
+with SCONJ O
+the DET O
+later ADJ O
+capable ADJ O
+of ADP O
+identifying VERB O
+ischemic ADJ O
+HIE PROPN B-AC
+lesions NOUN O
+in ADP O
+the DET O
+acute ADJ O
+phase NOUN O
+, PUNCT O
+several ADJ O
+days NOUN O
+earlier ADV O
+than ADP O
+the DET O
+former ADJ O
+. PUNCT O
+[ X O
+10,11 X O
+] X O
+Diffusion NOUN O
+MRI NOUN B-AC
+, PUNCT O
+including VERB O
+diffusion NOUN B-LF
+- PUNCT I-LF
+weighted VERB I-LF
+imaging NOUN I-LF
+( PUNCT O
+DWI PROPN B-AC
+) PUNCT O
+and CCONJ O
+quantitative ADJ O
+apparent ADJ B-LF
+diffusion NOUN I-LF
+coefficient NOUN I-LF
+( PUNCT O
+ADC PROPN B-AC
+) PUNCT O
+mapping NOUN O
+, PUNCT O
+may AUX O
+also ADV O
+provide VERB O
+additional ADJ O
+early ADJ O
+diagnostic ADJ O
+and CCONJ O
+prognostic ADJ O
+information NOUN O
+; PUNCT O
+several ADJ O
+studies NOUN O
+report VERB O
+an DET O
+association NOUN O
+between ADP O
+reduced VERB O
+ADC PROPN B-AC
+values NOUN O
+in ADP O
+the DET O
+posterior ADJ B-LF
+limb NOUN I-LF
+of ADP I-LF
+the DET I-LF
+internal ADJ I-LF
+capsule NOUN I-LF
+( PUNCT O
+PLIC PROPN B-AC
+) PUNCT O
+as ADP O
+well ADV O
+as ADP O
+an DET O
+association NOUN O
+between ADP O
+reduced VERB O
+ADC PROPN B-AC
+values NOUN O
+in ADP O
+the DET O
+basal ADJ B-LF
+ganglia NOUN I-LF
+and CCONJ I-LF
+thalami NOUN I-LF
+( PUNCT O
+BGT PROPN B-AC
+) PUNCT O
+and CCONJ O
+neurological ADJ O
+sequelae NOUN O
+. PUNCT O
+[ X O
+12–21 NUM O
+] X O
+
+RAP NOUN B-AC
+, PUNCT O
+rapamycin NOUN B-LF
+. PUNCT O
+
+Non ADJ O
+- PUNCT O
+proteolytic ADJ O
+ubiquitination NOUN O
+of ADP O
+peroxisome NOUN B-LF
+proliferator NOUN I-LF
+- PUNCT I-LF
+activated VERB I-LF
+receptor NOUN I-LF
+γ NOUN I-LF
+( PUNCT O
+PPARγ PROPN B-AC
+) PUNCT O
+by ADP O
+the DET O
+E3 NOUN B-AC
+ligase NOUN O
+Smurf1 PROPN O
+suppresses VERB O
+its PRON O
+transcriptional ADJ O
+activity NOUN O
+and CCONJ O
+plays VERB O
+a DET O
+critical ADJ O
+role NOUN O
+in ADP O
+preventing VERB O
+abnormal ADJ O
+accumulation NOUN O
+of ADP O
+fatty ADJ O
+acid NOUN O
+in ADP O
+the DET O
+liver NOUN O
+. PUNCT O
+
+The DET O
+2 NUM O
+human ADJ O
+oncogenic ADJ O
+gammaherpesviruses NOUN O
+Epstein PROPN B-LF
+– PUNCT I-LF
+Barr PROPN I-LF
+virus PROPN I-LF
+( PUNCT O
+EBV PROPN B-AC
+) PUNCT O
+and CCONJ O
+Kaposi PROPN B-LF
+’s PART I-LF
+sarcoma NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+herpesvirus NOUN I-LF
+( PUNCT O
+KSHV PROPN B-AC
+) PUNCT O
+are AUX O
+carried VERB O
+by ADP O
+a DET O
+large ADJ O
+proportion NOUN O
+of ADP O
+the DET O
+adult NOUN O
+population NOUN O
+worldwide ADV O
+and CCONJ O
+pose VERB O
+a DET O
+significant ADJ O
+risk NOUN O
+of ADP O
+infection NOUN O
+- PUNCT O
+associated VERB O
+morbidity NOUN O
+and CCONJ O
+mortality NOUN O
+, PUNCT O
+especially ADV O
+in ADP O
+immunocompromised ADJ O
+hosts NOUN O
+[ X O
+1–3 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+aim NOUN O
+of ADP O
+the DET O
+study NOUN O
+was AUX O
+to PART O
+investigate VERB O
+the DET O
+effect NOUN O
+of ADP O
+prenatal ADJ O
+exposure NOUN O
+factors NOUN O
+, PUNCT O
+including VERB O
+socio ADJ O
+- ADJ O
+demographic ADJ O
+, PUNCT O
+behavioural ADJ O
+, PUNCT O
+dietary ADJ O
+, PUNCT O
+physical ADJ O
+activity NOUN O
+, PUNCT O
+clinical ADJ O
+and CCONJ O
+environmental ADJ O
+on ADP O
+birth NOUN O
+outcomes NOUN O
+through ADP O
+the DET O
+mediation NOUN O
+of ADP O
+Favourable PROPN B-LF
+Fetal PROPN I-LF
+Growth PROPN I-LF
+Conditions PROPN I-LF
+( PUNCT O
+FFGC PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+ALT PROPN B-AC
+, PUNCT O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+; PUNCT O
+APTT PROPN B-AC
+, PUNCT O
+activated VERB B-LF
+partial ADJ I-LF
+thromboplastin NOUN I-LF
+time NOUN I-LF
+; PUNCT O
+AST PROPN B-AC
+, PUNCT O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+; PUNCT O
+CKD PROPN O
+, PUNCT O
+chronic ADJ O
+kidney NOUN O
+disease NOUN O
+; PUNCT O
+COPD NOUN B-AC
+, PUNCT O
+chronic ADJ O
+obstructive ADJ O
+pulmonary ADJ O
+disease NOUN O
+; PUNCT O
+PT NOUN B-AC
+, PUNCT O
+prothrombin NOUN B-LF
+time NOUN I-LF
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+respiratory ADJ B-LF
+rate NOUN I-LF
+; PUNCT O
+T NOUN O
+, PUNCT O
+temperature NOUN O
+
+In ADP O
+a DET O
+modeling VERB O
+study NOUN O
+, PUNCT O
+Cora PROPN O
+Bernard PROPN O
+and CCONJ O
+colleagues NOUN O
+examine VERB O
+the DET O
+cost NOUN O
+- NOUN O
+effectiveness NOUN O
+of ADP O
+opioid ADJ B-LF
+agonist NOUN I-LF
+therapy NOUN I-LF
+( PUNCT O
+OAT PROPN B-AC
+) PUNCT O
+, PUNCT O
+needle NOUN O
+- NOUN O
+syringe NOUN O
+exchange NOUN O
+programs NOUN O
+( PUNCT O
+NSP PROPN B-AC
+) PUNCT O
+, PUNCT O
+screening NOUN O
+and CCONJ O
+intensive ADJ O
+antiretroviral ADJ O
+therapy NOUN O
+programs NOUN O
+( PUNCT O
+Test PROPN B-AC
+& CCONJ B-AC
+Treat VERB B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+oral ADJ O
+HIV PROPN O
+pre NOUN B-LF
+- NOUN I-LF
+exposure NOUN I-LF
+prophylaxis NOUN I-LF
+( PUNCT O
+PrEP PROPN B-AC
+) PUNCT O
+for ADP O
+prevention NOUN O
+of ADP O
+HIV PROPN O
+in ADP O
+people NOUN O
+who PRON O
+inject VERB O
+drugs NOUN O
+. PUNCT O
+
+Genetic ADJ B-LF
+distance NOUN I-LF
+was AUX O
+estimated VERB O
+between ADP O
+a DET O
+pair NOUN O
+of ADP O
+inbred ADJ O
+lines NOUN O
+from ADP O
+6081 NUM O
+markers NOUN O
+using VERB O
+Roger PROPN O
+’s PART O
+genetic ADJ B-LF
+distance NOUN I-LF
+( PUNCT O
+GD PROPN B-AC
+) PUNCT O
+in ADP O
+powerMaker PROPN O
+version NOUN O
+3.25 NUM O
+[ PUNCT O
+40 NUM O
+] PUNCT O
+. PUNCT O
+
+PHA PROPN B-AC
+: PUNCT O
+Phytohemagglutinin NOUN B-LF
+; PUNCT O
+uRBC NOUN O
+: PUNCT O
+Uninfected ADJ O
+erythrocytes NOUN O
+; PUNCT O
+PNG PROPN B-AC
+: PUNCT O
+Papua PROPN B-LF
+New PROPN I-LF
+Guinea PROPN I-LF
+; PUNCT O
+N NOUN O
+: PUNCT O
+Non ADJ O
+- ADJ O
+malaria ADJ O
+infected ADJ O
+women NOUN O
+; PUNCT O
+AUS PROPN B-AC
+: PUNCT O
+Australia PROPN B-LF
+
+Statistical ADJ O
+analysis NOUN O
+performed VERB O
+with ADP O
+ANOVA PROPN O
+. PUNCT O
+CI NOUN B-AC
+: PUNCT O
+Cavitation NOUN B-LF
+Index PROPN I-LF
+; PUNCT O
+Gem NOUN B-AC
+5 NUM B-AC
+μM NOUN B-AC
+: PUNCT O
+Gemcitabine NOUN B-LF
+at ADP I-LF
+a DET I-LF
+concentration NOUN I-LF
+of ADP I-LF
+5 NUM I-LF
+μM NOUN I-LF
+
+The DET O
+RalBD PROPN B-AC
+( PUNCT O
+aa NOUN O
+397–518 NUM O
+of ADP O
+human ADJ O
+RalBP1 PROPN O
+) PUNCT O
+was AUX O
+subcloned VERB O
+into ADP O
+pGEX4T-1 PROPN O
+( PUNCT O
+Amersham PROPN O
+Biosciences PROPN O
+) PUNCT O
+and CCONJ O
+pEGFP PROPN O
+- PUNCT O
+C1 PROPN O
+. PUNCT O
+For ADP O
+short ADJ B-LF
+hairpin NOUN I-LF
+RNA NOUN I-LF
+( PUNCT O
+shRNA NOUN B-AC
+) PUNCT O
+knockdown NOUN O
+of ADP O
+RalBP1 PROPN O
+, PUNCT O
+pSUPER PROPN O
+RalBP1 PROPN O
+was AUX O
+generated VERB O
+by ADP O
+annealing VERB O
+oligonucleotides NOUN O
+containing VERB O
+nt NOUN O
+666–684 NUM O
+of ADP O
+rat NOUN O
+RalBP1 PROPN O
+cDNA NOUN O
+( PUNCT O
+U28830 PROPN O
+; PUNCT O
+critical ADJ O
+19 NUM O
+nt NOUN O
+, PUNCT O
+GCACGGCATGAAATGTGAA PROPN O
+) PUNCT O
+and CCONJ O
+subcloning VERB O
+into ADP O
+pSUPER.gfp/neo NOUN O
+( PUNCT O
+OligoEngine PROPN O
+) PUNCT O
+. PUNCT O
+pSUPER PROPN O
+RalA PROPN O
+was AUX O
+generated VERB O
+using VERB O
+oligonucleotides NOUN O
+containing VERB O
+nt NOUN O
+402–420 NUM O
+of ADP O
+rat NOUN O
+RalA PROPN O
+cDNA NOUN O
+( PUNCT O
+NM_031093 NOUN O
+; PUNCT O
+AAGGCAGGTTTCTGTAGAA PROPN O
+) PUNCT O
+. PUNCT O
+pSuper PROPN O
+RalA PROPN O
+scrambled VERB O
+was AUX O
+generated VERB O
+using VERB O
+oligonucleotides NOUN O
+containing VERB O
+the DET O
+following VERB O
+sequence NOUN O
+( PUNCT O
+GAACGAGTGTCTGTAAGTA PROPN O
+) PUNCT O
+. PUNCT O
+shRNA NOUN B-AC
+- PUNCT O
+resistant ADJ O
+RalA PROPN O
+rescue NOUN O
+construct NOUN O
+was AUX O
+generated VERB O
+by ADP O
+introducing VERB O
+point NOUN O
+mutations NOUN O
+into ADP O
+pcDNA3.1 NOUN O
+- PUNCT O
+HA PROPN O
+RalA PROPN O
+WT PROPN B-AC
+using VERB O
+QuickChange PROPN O
+kit NOUN O
+. PUNCT O
+
+More ADJ O
+processed VERB O
+AR42J PROPN O
+revealed VERB O
+higher ADJ O
+efficacy NOUN O
+in ADP O
+siRNA NOUN O
+transfection NOUN O
+indicated VERB O
+by ADP O
+reduced VERB O
+expression NOUN O
+of ADP O
+Glo NOUN B-AC
+- PUNCT B-AC
+I NOUN B-AC
+in ADP O
+qRT NOUN B-AC
+- PUNCT B-AC
+PCR NOUN B-AC
+. PUNCT O
+CN NOUN B-AC
+: PUNCT O
+cerulein NOUN B-LF
+, PUNCT O
+Dexa PROPN B-AC
+: PUNCT O
+dexamethasone NOUN B-LF
+, PUNCT O
+Glo NOUN B-AC
+- PUNCT B-AC
+I NOUN B-AC
+: PUNCT O
+Glyoxalase NOUN B-LF
+- PUNCT I-LF
+I. PUNCT I-LF
+
+In ADP O
+newly ADV O
+diagnosed VERB O
+people NOUN B-LF
+with ADP I-LF
+Parkinson PROPN I-LF
+’s PART I-LF
+( PUNCT O
+PwP PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+response NOUN O
+to PART O
+a DET O
+single ADJ O
+drug NOUN O
+intake NOUN O
+may AUX O
+last VERB O
+for ADP O
+several ADJ O
+hours NOUN O
+, PUNCT O
+whereas SCONJ O
+with ADP O
+the DET O
+progression NOUN O
+of ADP O
+the DET O
+disease NOUN O
+the DET O
+drug NOUN O
+’s PART O
+effect NOUN O
+is AUX O
+shortened VERB O
+( PUNCT O
+4 NUM O
+hours NOUN O
+or CCONJ O
+less ADJ O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+patients NOUN O
+need VERB O
+to PART O
+decrease VERB O
+intervals NOUN O
+between ADP O
+doses NOUN O
+and/or CCONJ O
+increase VERB O
+the DET O
+dosages NOUN O
+[ X O
+5,6 NUM O
+] X O
+” PUNCT O
+. PUNCT O
+
+Shown VERB O
+is AUX O
+( PUNCT O
+a DET O
+) PUNCT O
+a DET O
+Jitter NOUN O
+plot NOUN O
+illustrating VERB O
+the DET O
+distribution NOUN O
+of ADP O
+individual ADJ O
+propensity NOUN O
+scores NOUN O
+and CCONJ O
+( PUNCT O
+b X O
+) PUNCT O
+a DET O
+line NOUN O
+plot NOUN O
+displaying VERB O
+the DET O
+absolute ADJ O
+standardized ADJ B-LF
+mean NOUN I-LF
+differences NOUN I-LF
+( PUNCT O
+SMD NOUN B-AC
+) PUNCT O
+of ADP O
+each DET O
+matching VERB O
+covariate NOUN O
+. PUNCT O
+
+UCP-1 NOUN B-AC
+immunostaining NOUN O
+in ADP O
+sections NOUN O
+of ADP O
+inguinal ADJ O
+white ADJ O
+adipose ADJ O
+tissue NOUN O
+( PUNCT O
+ingWAT NOUN O
+) PUNCT O
+obtained VERB O
+from ADP O
+mice NOUN O
+after ADP O
+treatment NOUN O
+with ADP O
+vehicle NOUN O
+, PUNCT O
+rosiglitazone NOUN B-LF
+( PUNCT O
+RSG PROPN B-AC
+, PUNCT O
+4 NUM O
+mg NOUN O
+/ SYM O
+kg NOUN O
+/ SYM O
+d NOUN O
+) PUNCT O
+, PUNCT O
+or CCONJ O
+QG-16 PROPN O
+( PUNCT O
+40 NUM O
+mg NOUN O
+/ SYM O
+kg NOUN O
+/ SYM O
+d NOUN O
+) PUNCT O
+for ADP O
+two NUM O
+weeks NOUN O
+. PUNCT O
+
+Since SCONJ O
+time NOUN B-LF
+to ADP I-LF
+progression NOUN I-LF
+( PUNCT O
+TTP PROPN B-AC
+) PUNCT O
+was AUX O
+uncensored ADJ O
+, PUNCT O
+we PRON O
+were AUX O
+able ADJ O
+to ADP O
+use VERB O
+( PUNCT O
+multivariate ADJ O
+) PUNCT O
+linear ADJ O
+regression NOUN O
+models NOUN O
+to ADP O
+relate VERB O
+TTP PROPN B-AC
+to ADP O
+the DET O
+molecular ADJ O
+and CCONJ O
+clinical ADJ O
+variables NOUN O
+. PUNCT O
+
+Because SCONJ O
+Dilp-2 NOUN B-AC
+is AUX O
+normally ADV O
+expressed VERB O
+in ADP O
+the DET O
+IPCs NOUN B-AC
+[ X O
+42,43 NUM O
+] X O
+and CCONJ O
+not PART O
+BBB PROPN B-AC
+( PUNCT O
+blood NOUN B-LF
+– PUNCT I-LF
+brain NOUN I-LF
+barrier NOUN I-LF
+) PUNCT O
+glia NOUN O
+, PUNCT O
+this PRON O
+suggests VERB O
+that SCONJ O
+Dilp-2 NOUN B-AC
+is AUX O
+required VERB O
+in ADP O
+IPCs NOUN B-AC
+for ADP O
+neuroblast ADJ O
+reactivation NOUN O
+in ADP O
+the DET O
+brain NOUN O
+. PUNCT O
+
+Recrudescent ADJ O
+infections NOUN O
+( PUNCT O
+estimated VERB O
+by ADP O
+the DET O
+PCR NOUN O
+- PUNCT O
+corrected VERB O
+failure NOUN O
+rate NOUN O
+, PUNCT O
+not PART O
+shown VERB O
+) PUNCT O
+were AUX O
+assumed VERB O
+to PART O
+reappear VERB O
+uniformly ADV O
+throughout ADP O
+the DET O
+observation NOUN O
+period NOUN O
+. PUNCT O
+( PUNCT O
+B NOUN O
+) PUNCT O
+Example NOUN O
+simulations NOUN O
+of ADP O
+placental ADJ O
+prevalence NOUN O
+by ADP O
+week NOUN O
+of ADP O
+gestation NOUN O
+in ADP O
+the DET O
+absence NOUN O
+of ADP O
+intervention NOUN O
+, PUNCT O
+and CCONJ O
+where SCONJ O
+sulphadoxine NOUN B-LF
+- PUNCT I-LF
+pyrimethamine NOUN I-LF
+is AUX O
+given VERB O
+at ADP O
+17 NUM O
+, PUNCT O
+25 NUM O
+, PUNCT O
+and CCONJ O
+32 NUM O
+wk NOUN O
+gestation NOUN O
+at ADP O
+the DET O
+different ADJ O
+levels NOUN O
+of ADP O
+resistance NOUN O
+. PUNCT O
+( PUNCT O
+C NOUN O
+) PUNCT O
+How SCONJ O
+efficacy NOUN O
+of ADP O
+IPTp PROPN B-AC
+- PUNCT B-AC
+SP PROPN B-AC
+against ADP O
+LBW PROPN B-AC
+is AUX O
+assumed VERB O
+to PART O
+vary VERB O
+by ADP O
+resistance NOUN O
+category NOUN O
+and CCONJ O
+transmission NOUN O
+intensity NOUN O
+( PUNCT O
+based VERB O
+on ADP O
+changes NOUN O
+in ADP O
+the DET O
+estimated VERB O
+average ADJ O
+time NOUN O
+spent VERB O
+infected VERB O
+) PUNCT O
+. PUNCT O
+
+g X O
+SFA NOUN B-AC
+, PUNCT O
+Saturated ADJ B-LF
+fatty ADJ I-LF
+acids NOUN I-LF
+. PUNCT O
+
+The DET O
+objective NOUN O
+of ADP O
+this DET O
+study NOUN O
+is AUX O
+to PART O
+determine VERB O
+the DET O
+publication NOUN O
+rate NOUN O
+of ADP O
+efficacy NOUN O
+trials NOUN O
+submitted VERB O
+to PART O
+the DET O
+Food PROPN B-LF
+and CCONJ I-LF
+Drug PROPN I-LF
+Administration PROPN I-LF
+( PUNCT O
+FDA PROPN B-AC
+) PUNCT O
+in ADP O
+approved VERB O
+New PROPN B-LF
+Drug PROPN I-LF
+Applications PROPN I-LF
+( PUNCT O
+NDAs PROPN B-AC
+) PUNCT O
+and CCONJ O
+to PART O
+compare VERB O
+the DET O
+trial NOUN O
+characteristics NOUN O
+as SCONJ O
+reported VERB O
+by ADP O
+the DET O
+FDA PROPN B-AC
+with ADP O
+those PRON O
+reported VERB O
+in ADP O
+publications NOUN O
+. PUNCT O
+
+High ADJ O
+expectations NOUN O
+have AUX O
+recently ADV O
+been AUX O
+placed VERB O
+on ADP O
+the DET O
+development NOUN O
+and CCONJ O
+validation NOUN O
+of ADP O
+a DET O
+minimally ADV B-LF
+invasive ADJ I-LF
+autopsy NOUN I-LF
+( PUNCT O
+MIA PROPN B-AC
+) PUNCT O
+tool NOUN O
+[ PUNCT O
+6 NUM O
+] PUNCT O
+, PUNCT O
+an DET O
+approach NOUN O
+based VERB O
+on ADP O
+postmortem ADJ O
+sampling NOUN O
+of ADP O
+key ADJ O
+organs NOUN O
+using VERB O
+needle NOUN O
+biopsies NOUN O
+. PUNCT O
+
+AMPK PROPN B-AC
+, PUNCT O
+AMP PROPN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+; PUNCT O
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+mTOR PROPN B-AC
+, PUNCT O
+mammalian ADJ B-LF
+target NOUN I-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+rapamycin NOUN I-LF
+; PUNCT O
+ULK1 PROPN B-AC
+, PUNCT O
+unc-51 NOUN O
+- PUNCT O
+like ADJ O
+autophagy NOUN O
+activating VERB O
+kinase NOUN O
+1 NUM O
+. PUNCT O
+
+AOR PROPN B-AC
+, PUNCT O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+OR PROPN O
+, PUNCT O
+odds NOUN O
+ratio NOUN O
+; PUNCT O
+UBL PROPN B-AC
+, PUNCT O
+Unite PROPN B-LF
+for ADP I-LF
+a DET I-LF
+Better PROPN I-LF
+Life PROPN I-LF
+. PUNCT O
+
+Two NUM O
+fundamental ADJ O
+mechanisms NOUN O
+, PUNCT O
+namely ADV O
+the DET O
+homologous ADJ B-LF
+recombination NOUN I-LF
+( PUNCT O
+HR NOUN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+non ADJ O
+- PUNCT O
+homologous ADJ O
+- PUNCT O
+end NOUN O
+joining NOUN O
+( PUNCT O
+NHEJ PROPN B-AC
+) PUNCT O
+pathways NOUN O
+are AUX O
+involved VERB O
+in ADP O
+repair NOUN O
+of ADP O
+DSBs NOUN B-AC
+[ PUNCT O
+17,18 NUM O
+] PUNCT O
+. PUNCT O
+
+CSF PROPN B-AC
+- PUNCT B-AC
+cN NOUN B-AC
+, PUNCT O
+cerebrospinal ADJ B-LF
+fluid NOUN I-LF
+- PUNCT I-LF
+contacting VERB I-LF
+neuron NOUN I-LF
+; PUNCT O
+hpf NOUN B-AC
+, PUNCT O
+hours NOUN B-LF
+post ADP I-LF
+fertilization NOUN I-LF
+. PUNCT O
+
+Thus ADV O
+, PUNCT O
+even ADV O
+non ADJ O
+- ADJ O
+obstructive ADJ O
+kidney NOUN O
+stones NOUN O
+in ADP O
+cats NOUN O
+affect VERB O
+the DET O
+rate NOUN O
+of ADP O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CKD PROPN B-AC
+) PUNCT O
+progression NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+TMA NOUN B-AC
+= PUNCT O
+Thrombotic ADJ B-LF
+microangiopathy NOUN I-LF
+; PUNCT O
+eGFR NOUN B-AC
+= PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+SE NOUN O
+= PUNCT O
+standard ADJ O
+error NOUN O
+. PUNCT O
+
+DEG PROPN B-AC
+, PUNCT O
+differentially ADV B-LF
+expressed VERB I-LF
+gene NOUN I-LF
+; PUNCT O
+GO PROPN B-AC
+, PUNCT O
+gene NOUN B-LF
+ontology NOUN I-LF
+. PUNCT O
+
+CD4 PROPN B-AC
+, PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+4 NUM I-LF
+; PUNCT O
+CD25 PROPN B-AC
+, PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+25 NUM I-LF
+; PUNCT O
+FACS PROPN O
+, PUNCT O
+fluorescence NOUN O
+- PUNCT O
+activated VERB O
+cell NOUN O
+sorting NOUN O
+; PUNCT O
+Foxp3 PROPN B-AC
+, PUNCT O
+forkhead NOUN B-LF
+box NOUN I-LF
+P3 NOUN I-LF
+; PUNCT O
+GMFI PROPN B-AC
+, PUNCT O
+geometric ADJ B-LF
+mean NOUN I-LF
+fluorescence NOUN I-LF
+intensity NOUN I-LF
+; PUNCT O
+IL-4Rα PROPN B-AC
+, PUNCT O
+interleukin-4 NOUN O
+receptor NOUN O
+alpha NOUN O
+; PUNCT O
+iTreg PROPN B-AC
+, PUNCT O
+induced VERB B-LF
+Treg PROPN I-LF
+; PUNCT O
+NS PROPN B-AC
+, PUNCT O
+not PART B-LF
+significant ADJ I-LF
+; PUNCT O
+rIL-4 PROPN B-AC
+, PUNCT O
+recombinant ADJ O
+interleukin-4 NOUN O
+; PUNCT O
+TCR PROPN O
+, PUNCT O
+T NOUN O
+- PUNCT O
+cell NOUN O
+receptor NOUN O
+; PUNCT O
+TGFβ PROPN O
+, PUNCT O
+transforming VERB O
+growth NOUN O
+factor NOUN O
+beta NOUN O
+; PUNCT O
+Treg PROPN B-AC
+, PUNCT O
+regulatory ADJ B-LF
+T. NOUN I-LF
+
+Lateral ADJ O
+flow NOUN O
+urine NOUN O
+lipoarabinomannan NOUN B-LF
+( PUNCT O
+LAM PROPN B-AC
+) PUNCT O
+tests NOUN O
+could AUX O
+offer VERB O
+important ADJ O
+new ADJ O
+opportunities NOUN O
+for ADP O
+the DET O
+early ADJ O
+detection NOUN O
+of ADP O
+tuberculosis NOUN B-LF
+( PUNCT O
+TB PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+currently ADV O
+licensed VERB O
+LAM PROPN B-AC
+test NOUN O
+, PUNCT O
+Alere PROPN O
+Determine PROPN O
+TB PROPN B-AC
+LAM PROPN B-AC
+Ag PROPN O
+( PUNCT O
+‘ PUNCT O
+LF PROPN O
+- PUNCT O
+LAM PROPN B-AC
+’ PUNCT O
+) PUNCT O
+, PUNCT O
+performs VERB O
+best ADV O
+in ADP O
+the DET O
+sickest ADJ O
+people NOUN B-LF
+living VERB I-LF
+with ADP I-LF
+HIV PROPN I-LF
+( PUNCT O
+PLHIV PROPN B-AC
+) PUNCT O
+. PUNCT O
+However ADV O
+, PUNCT O
+the DET O
+technology NOUN O
+continues VERB O
+to PART O
+improve VERB O
+, PUNCT O
+with ADP O
+newer ADJ O
+LAM PROPN B-AC
+tests NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+Fujifilm PROPN O
+SILVAMP PROPN O
+TB PROPN B-AC
+LAM PROPN B-AC
+( PUNCT O
+‘ PUNCT O
+SILVAMP PROPN O
+- PUNCT O
+LAM PROPN B-AC
+’ PUNCT O
+) PUNCT O
+showing VERB O
+improved ADJ O
+sensitivity NOUN O
+, PUNCT O
+including VERB O
+amongst ADP O
+HIV PROPN O
+- PUNCT O
+negative ADJ O
+patients NOUN O
+. PUNCT O
+
+The DET O
+outbreak NOUN O
+of ADP O
+COVID-19 PROPN B-AC
+was AUX O
+first ADV O
+begun VERB O
+in ADP O
+Wuhan PROPN O
+, PUNCT O
+Hubei PROPN O
+state NOUN O
+of ADP O
+China PROPN O
+and CCONJ O
+was AUX O
+first ADV O
+reported VERB O
+by ADP O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+on ADP O
+the DET O
+31st NOUN O
+December PROPN O
+2019 NUM O
+and CCONJ O
+announced VERB O
+as ADP O
+a DET O
+global ADJ O
+pandemic NOUN O
+on ADP O
+30th NUM O
+January PROPN O
+2020 NUM O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+We PRON O
+therefore ADV O
+chose VERB O
+to PART O
+identify VERB O
+important ADJ O
+explanatory ADJ O
+variables NOUN O
+directly ADV O
+in ADP O
+a DET O
+geographically ADV B-LF
+weighted VERB I-LF
+regression NOUN I-LF
+( PUNCT O
+GWR PROPN B-AC
+) PUNCT O
+model NOUN O
+. PUNCT O
+
+Psychosocial ADJ O
+factors NOUN O
+most ADV O
+strongly ADV O
+associated VERB O
+with ADP O
+serious ADJ O
+injury NOUN O
+were AUX O
+being AUX O
+bullied VERB O
+( PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+[ X O
+OR PROPN B-AC
+] X O
+2.45 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.93 NUM O
+to PART O
+3.13 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+, PUNCT O
+drug NOUN O
+use NOUN O
+( PUNCT O
+OR PROPN B-AC
+2.08 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.73 NUM O
+to PART O
+2.49 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+, PUNCT O
+attempting VERB O
+suicide NOUN O
+( PUNCT O
+OR PROPN B-AC
+1.78 NUM O
+, PUNCT O
+CI NOUN O
+1.55 NUM O
+to PART O
+2.04 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+, PUNCT O
+being AUX O
+too ADV O
+worried ADJ O
+to PART O
+sleep VERB O
+( PUNCT O
+OR PROPN B-AC
+1.80 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.54 NUM O
+to PART O
+2.10 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+, PUNCT O
+feeling VERB O
+lonely ADJ O
+( PUNCT O
+OR PROPN B-AC
+1.61 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.37 NUM O
+to PART O
+1.89 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+going VERB O
+hungry ADJ O
+( PUNCT O
+OR PROPN B-AC
+1.61 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.30 NUM O
+to PART O
+2.01 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+. PUNCT O
+
+Then ADV O
+, PUNCT O
+in ADP O
+1996 NUM O
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+( PUNCT O
+ART PROPN B-AC
+) PUNCT O
+became VERB O
+available ADJ O
+, PUNCT O
+and CCONJ O
+for ADP O
+people NOUN O
+living VERB O
+in ADP O
+affluent ADJ O
+countries NOUN O
+, PUNCT O
+HIV PROPN O
+/ SYM O
+AIDS PROPN O
+became VERB O
+a DET O
+chronic ADJ O
+condition NOUN O
+. PUNCT O
+
+MS PROPN B-AC
+, PUNCT O
+mass NOUN B-LF
+spectrometry NOUN I-LF
+; PUNCT O
+RNAi NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+. PUNCT O
+
+We PRON O
+tested VERB O
+the DET O
+hypothesis NOUN O
+that SCONJ O
+the DET O
+odds NOUN O
+of ADP O
+malaria NOUN O
+infection NOUN O
+are AUX O
+lower ADJ O
+in ADP O
+modern ADJ O
+, PUNCT O
+improved ADJ O
+housing NOUN O
+compared VERB O
+to ADP O
+traditional ADJ O
+housing NOUN O
+in ADP O
+sub PROPN B-LF
+- PROPN I-LF
+Saharan PROPN I-LF
+Africa PROPN I-LF
+( PUNCT O
+SSA PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Plasma NOUN O
+creatine NOUN B-LF
+kinase NOUN I-LF
+( PUNCT O
+CK PROPN B-AC
+) PUNCT O
+levels NOUN O
+were AUX O
+measured VERB O
+on ADP O
+test NOUN O
+days NOUN O
+and CCONJ O
+after ADP O
+three NUM O
+weeks NOUN O
+of ADP O
+training NOUN O
+as ADP O
+a DET O
+marker NOUN O
+of ADP O
+exercise NOUN O
+- PUNCT O
+induced VERB O
+muscle NOUN O
+damage NOUN O
+. PUNCT O
+
+The DET O
+CI PROPN B-AC
+is AUX O
+derived VERB O
+from ADP O
+the DET O
+concentration NOUN B-LF
+curve NOUN I-LF
+( PUNCT O
+CC PROPN B-AC
+) PUNCT O
+which PRON O
+plots VERB O
+the DET O
+cumulative ADJ O
+percentage NOUN O
+of ADP O
+the DET O
+health NOUN O
+variable NOUN O
+against ADP O
+the DET O
+cumulative ADJ O
+percentage NOUN O
+of ADP O
+the DET O
+population NOUN O
+ranked VERB O
+by ADP O
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+living NOUN O
+standards NOUN O
+measure NOUN O
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+12 NUM O
+] PUNCT O
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+the DET O
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+measured VERB O
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+the DET O
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+degree NOUN O
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+In ADP O
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+in ADP O
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+dorsomedial ADJ O
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+at ADP O
+zeitgeber NOUN B-LF
+time NOUN I-LF
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+ZT)2 PROPN B-AC
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+ZT6 NOUN O
+, PUNCT O
+in ADP O
+comparison NOUN O
+to ADP O
+the DET O
+night NOUN O
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+ZT14 PROPN O
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+ZT18 NOUN O
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+p NOUN O
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+0.001 NUM O
+; PUNCT O
+Figure NOUN O
+7C NUM O
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+contrast NOUN O
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+expressing VERB O
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+- ADJ O
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+- ADJ O
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+cycles NOUN O
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+phase NOUN O
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+peaking VERB O
+late ADJ O
+night NOUN O
+, PUNCT O
+rather ADV O
+than ADP O
+early ADV O
+in ADP O
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+morning NOUN O
+, PUNCT O
+with ADP O
+peak ADJ O
+anti ADJ O
+- ADJ O
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+0.001 NUM O
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+moment NOUN I-LF
+M0 NOUN B-AC
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+obtained VERB O
+using VERB O
+Eq NOUN O
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+1 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+then ADV O
+, PUNCT O
+the DET B-LF
+moment NOUN I-LF
+magnitude NOUN I-LF
+MW NOUN O
+was AUX O
+calculated VERB O
+based VERB O
+on ADP O
+the DET O
+empirical ADJ O
+relationship NOUN O
+between ADP O
+the DET B-LF
+seismic ADJ I-LF
+moment NOUN I-LF
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+the DET B-LF
+moment NOUN I-LF
+magnitude NOUN I-LF
+MW NOUN O
+[ SYM O
+25,6 NUM O
+] PUNCT O
+: PUNCT O
+Mw=23lgM0−6.07.(2 NUM B-AC
+) PUNCT O
+
+When SCONJ O
+we PRON O
+assessed VERB O
+the DET O
+presence NOUN O
+of ADP O
+inflammation NOUN O
+in ADP O
+the DET O
+CNS PROPN B-AC
+of ADP O
+Nlrx1−/− NOUN O
+2D2 NUM O
+spEAE NOUN B-AC
+mice NOUN O
+, PUNCT O
+we PRON O
+found VERB O
+that SCONJ O
+the DET O
+lack NOUN O
+of ADP O
+NLRX1 PROPN B-AC
+did AUX O
+not PART O
+affect VERB O
+the DET O
+expression NOUN O
+of ADP O
+glial NOUN B-LF
+fibrillary NOUN I-LF
+acidic ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+GFAP PROPN B-AC
+) PUNCT O
+, PUNCT O
+ionized VERB B-LF
+calcium NOUN I-LF
+binding VERB I-LF
+adaptor NOUN I-LF
+molecule NOUN I-LF
+1(Iba1 PROPN I-LF
+) PUNCT O
+, PUNCT O
+and CCONJ O
+myelin NOUN B-LF
+basic ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+MBP PROPN B-AC
+) PUNCT O
+in ADP O
+the DET O
+spinal ADJ O
+cords NOUN O
+of ADP O
+healthy ADJ O
+Nlrx1−/− NOUN O
+2D2 NUM O
+mice NOUN O
+( PUNCT O
+S1A PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+( PUNCT O
+A NOUN O
+, PUNCT O
+D NOUN O
+, PUNCT O
+G NOUN O
+, PUNCT O
+J NOUN O
+) PUNCT O
+Neutrophil NOUN O
+( PUNCT O
+GR1 NOUN O
++ NOUN O
+cells NOUN O
+) PUNCT O
+quantifications NOUN O
+( PUNCT O
+expressed VERB O
+as ADP O
+number NOUN O
+of ADP O
+cells NOUN O
+per ADP O
+ten NUM O
+microscopic ADJ O
+fields NOUN O
+at ADP O
+40X NUM O
+) PUNCT O
+in ADP O
+the DET O
+FI PROPN B-AC
+( PUNCT O
+A NOUN O
+) PUNCT O
+, PUNCT O
+NTX PROPN B-AC
+( PUNCT O
+D NOUN O
+) PUNCT O
+, PUNCT O
+CTX PROPN B-AC
+( PUNCT O
+G NOUN O
+) PUNCT O
+and CCONJ O
+BaCl2 PROPN B-AC
+( PUNCT O
+J NOUN O
+) PUNCT O
+. PUNCT O
+( PUNCT O
+B NOUN O
+, PUNCT O
+E NOUN O
+, PUNCT O
+H NOUN O
+, PUNCT O
+K NOUN O
+) PUNCT O
+Macrophage NOUN O
+( PUNCT O
+F4/80 NOUN O
++ NOUN O
+cells NOUN O
+) PUNCT O
+quantifications NOUN O
+( PUNCT O
+expressed VERB O
+as ADP O
+number NOUN O
+of ADP O
+cells NOUN O
+per ADP O
+field NOUN O
+) PUNCT O
+in ADP O
+the DET O
+FI PROPN B-AC
+( PUNCT O
+B NOUN O
+) PUNCT O
+, PUNCT O
+NTX PROPN B-AC
+( PUNCT O
+E NOUN O
+) PUNCT O
+, PUNCT O
+CTX PROPN B-AC
+( PUNCT O
+H NOUN O
+) PUNCT O
+and CCONJ O
+BaCl2 PROPN B-AC
+( PUNCT O
+K NOUN O
+) PUNCT O
+. PUNCT O
+Data NOUN O
+are AUX O
+represented VERB O
+as ADP O
+means±s.d NOUN O
+. PUNCT O
+* PUNCT O
+p NOUN O
+< SYM O
+0.05 NUM O
+; PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< SYM O
+0.01 NUM O
+; PUNCT O
+* PUNCT O
+* PUNCT O
+* PUNCT O
+p NOUN O
+< SYM O
+0.001 NUM O
+; PUNCT O
+no DET O
+star NOUN O
+, PUNCT O
+statistically ADV O
+non ADJ O
+significant ADJ O
+. PUNCT O
+( PUNCT O
+C PROPN O
+, PUNCT O
+F PROPN O
+, PUNCT O
+I PROPN O
+, PUNCT O
+L PROPN O
+) PUNCT O
+Luminex PROPN O
+( PUNCT O
+multiplex NOUN O
+assay NOUN O
+) PUNCT O
+measuring VERB O
+the DET O
+levels NOUN O
+of ADP O
+cytokines NOUN O
+in ADP O
+pg NOUN O
+/ SYM O
+g NOUN O
+of ADP O
+muscle NOUN O
+tissue NOUN O
+, PUNCT O
+18h NUM O
+, PUNCT O
+4 NUM O
+days NOUN O
+, PUNCT O
+12 NUM O
+days NOUN O
+and CCONJ O
+1 NUM O
+month NOUN O
+post NOUN O
+- NOUN O
+injury NOUN O
+in ADP O
+the DET O
+freeze NOUN B-LF
+injury NOUN I-LF
+model NOUN O
+( PUNCT O
+C PROPN O
+) PUNCT O
+, PUNCT O
+the DET O
+NTX PROPN B-AC
+( PUNCT O
+F PROPN O
+) PUNCT O
+, PUNCT O
+the DET O
+CTX PROPN B-AC
+( PUNCT O
+I PROPN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+BaCl2 PROPN B-AC
+( PUNCT O
+L PROPN O
+) PUNCT O
+. PUNCT O
+Selected VERB O
+cytokines NOUN O
+( PUNCT O
+IL6 PROPN O
+; PUNCT O
+IL10 PROPN O
+; PUNCT O
+MCP1 PROPN O
+; PUNCT O
+MIP1a PROPN O
+and CCONJ O
+MIG PROPN B-AC
+) PUNCT O
+are AUX O
+displayed VERB O
+for ADP O
+each DET O
+injury NOUN O
+model NOUN O
+. PUNCT O
+
+The DET O
+regulatory ADJ O
+regions NOUN O
+of ADP O
+these DET O
+inducible ADJ O
+genes NOUN O
+encode VERB O
+the DET O
+electrophile ADJ B-LF
+- PUNCT I-LF
+response NOUN I-LF
+element NOUN I-LF
+( PUNCT O
+EpRE PROPN B-AC
+) PUNCT O
+. PUNCT O
+This DET O
+study NOUN O
+tested VERB O
+the DET O
+EpRE PROPN B-AC
+induction NOUN O
+ability NOUN O
+of ADP O
+Maerua PROPN O
+subcordata NOUN O
+( PUNCT O
+fruit NOUN O
+, PUNCT O
+leaf NOUN O
+, PUNCT O
+root NOUN O
+, PUNCT O
+seed NOUN O
+) PUNCT O
+methanol NOUN O
+extracts NOUN O
+and CCONJ O
+selected VERB O
+candidate NOUN O
+constituents NOUN O
+thereof ADV O
+, PUNCT O
+identified VERB O
+by ADP O
+liquid NOUN O
+chromatography NOUN O
+coupled VERB O
+with ADP O
+multistage ADJ O
+mass NOUN O
+spectroscopy NOUN O
+, PUNCT O
+employing VERB O
+an DET O
+EpRE PROPN B-AC
+luciferase NOUN O
+reporter NOUN O
+gene NOUN O
+assay NOUN O
+using VERB O
+hepa-1c1c7 NOUN O
+mouse NOUN O
+hepatoma NOUN O
+cells NOUN O
+. PUNCT O
+
+We PRON O
+identified VERB O
+X NOUN O
+- NOUN O
+rays NOUN O
+, PUNCT O
+computerized VERB B-LF
+tomography NOUN I-LF
+( PUNCT O
+CT PROPN B-AC
+) PUNCT O
+scans NOUN O
+, PUNCT O
+single ADJ B-LF
+photon NOUN I-LF
+emission NOUN I-LF
+computerized VERB I-LF
+tomography NOUN I-LF
+( PUNCT O
+SPECT PROPN B-AC
+) PUNCT O
+, PUNCT O
+ultrasound NOUN O
+, PUNCT O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+MRI PROPN B-AC
+) PUNCT O
+, PUNCT O
+nuclear ADJ O
+imaging NOUN O
+and CCONJ O
+endoscopy NOUN O
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+ISIS PROPN B-AC
+, PUNCT O
+Islamic PROPN B-LF
+State PROPN I-LF
+of ADP I-LF
+Iraq PROPN I-LF
+and CCONJ I-LF
+Syria PROPN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+LEA PROPN B-AC
+, PUNCT O
+lower ADJ B-LF
+extremity NOUN I-LF
+amputation NOUN I-LF
+; PUNCT O
+DFU PROPN B-AC
+, PUNCT O
+diabetic ADJ B-LF
+foot NOUN I-LF
+ulcer NOUN I-LF
+. PUNCT O
+
+Moreover ADV O
+, PUNCT O
+the DET O
+importance NOUN O
+of ADP O
+the DET O
+two NUM O
+NUE NOUN B-AC
+components NOUN O
+, PUNCT O
+NUpE PROPN B-AC
+and CCONJ O
+N PROPN B-LF
+utilisation NOUN I-LF
+efficiency NOUN I-LF
+( PUNCT O
+NUtE PROPN B-AC
+) PUNCT O
+are AUX O
+variable ADJ O
+, PUNCT O
+mostly ADV O
+depending VERB O
+on ADP O
+the DET O
+amount NOUN O
+of ADP O
+the DET O
+available ADJ O
+N. NOUN O
+
+The DET O
+Autism PROPN B-LF
+Diagnostic PROPN I-LF
+Observation PROPN I-LF
+Schedule PROPN I-LF
+— PUNCT O
+ADOS PROPN B-AC
+[ X O
+25 NUM O
+] X O
+was AUX O
+used VERB O
+to PART O
+confirm VERB O
+diagnoses NOUN O
+. PUNCT O
+
+Typical ADJ O
+relative ADJ O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+( PUNCT O
+SEM PROPN B-AC
+) PUNCT O
+= PUNCT O
+20 NUM O
+% PUNCT O
+. PUNCT O
+
+A DET O
+systematic ADJ O
+search NOUN O
+of ADP O
+relevant ADJ O
+articles NOUN O
+in ADP O
+Pubmed PROPN O
+, PUNCT O
+Wanfang PROPN O
+, PUNCT O
+Chinese PROPN B-LF
+Scientific PROPN I-LF
+Journals PROPN I-LF
+Fulltext PROPN I-LF
+Database PROPN I-LF
+( PUNCT O
+CQVIP PROPN B-AC
+) PUNCT O
+, PUNCT O
+China PROPN B-LF
+National PROPN I-LF
+Knowledge PROPN I-LF
+Infrastructure PROPN I-LF
+( PUNCT O
+CNKI PROPN B-AC
+) PUNCT O
+and CCONJ O
+China PROPN B-LF
+Biology PROPN I-LF
+Medicine PROPN I-LF
+disc NOUN I-LF
+( PUNCT O
+CBMdisc PROPN B-AC
+) PUNCT O
+was AUX O
+undertaken VERB O
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+two NUM O
+researchers NOUN O
+on ADP O
+September PROPN O
+1,2017 NUM O
+. PUNCT O
+
+Disinfection NOUN B-LF
+by NOUN I-LF
+- PUNCT I-LF
+products NOUN I-LF
+( PUNCT O
+DBPs PROPN B-AC
+) PUNCT O
+formation NOUN O
+in ADP O
+the DET O
+treatment NOUN O
+of ADP O
+drinking NOUN O
+water NOUN O
+could AUX O
+cause VERB O
+long ADJ O
+- PUNCT O
+term NOUN O
+adverse ADJ O
+health NOUN O
+effects NOUN O
+on ADP O
+humans NOUN O
+. PUNCT O
+
+Baltimore PROPN B-LF
+Longitudinal PROPN I-LF
+Study PROPN I-LF
+of ADP I-LF
+Aging PROPN I-LF
+( PUNCT O
+BLSA PROPN B-AC
+) PUNCT O
+data NOUN O
+are AUX O
+available ADJ O
+to ADP O
+researchers NOUN O
+and CCONJ O
+can AUX O
+be AUX O
+requested VERB O
+at ADP O
+https://www.blsa.nih.gov/researchers X O
+. PUNCT O
+
+The DET O
+standard ADJ O
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+of ADP O
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+asymmetry NOUN O
+, PUNCT O
+which PRON O
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+9.83 NUM O
+% NOUN O
+was AUX O
+considered VERB O
+as ADP O
+the DET O
+Index PROPN B-LF
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+Asymmetry PROPN I-LF
+( PUNCT O
+AI PROPN B-AC
+) PUNCT O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+HDL PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+cholesterol NOUN I-LF
+; PUNCT O
+LDL NOUN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+cholesterol NOUN I-LF
+; PUNCT O
+TC PROPN B-AC
+, PUNCT O
+total ADJ B-LF
+cholesterol NOUN I-LF
+; PUNCT O
+TG NOUN B-AC
+, PUNCT O
+triglyceride NOUN B-LF
+; PUNCT O
+MPR PROPN B-AC
+, PUNCT O
+medication NOUN B-LF
+possession NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+
+The DET O
+surface NOUN B-LF
+under ADP I-LF
+the DET I-LF
+cumulative ADJ I-LF
+ranking NOUN I-LF
+curve NOUN I-LF
+( PUNCT O
+SUCRA PROPN B-AC
+) PUNCT O
+represents VERB O
+the DET O
+ranking NOUN O
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+devices NOUN O
+. PUNCT O
+
+To PART O
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+regulated VERB O
+, PUNCT O
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+first ADV O
+generated VERB O
+a DET O
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+dimeric ADJ I-LF
+Tomato PROPN I-LF
+( PUNCT O
+tdTomato PROPN B-AC
+) PUNCT O
+reporter NOUN O
+ESC NOUN B-AC
+line NOUN O
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+transgenic ADJ O
+expression NOUN O
+of ADP O
+red ADJ O
+fluorescence NOUN O
+protein NOUN O
+tdTomato PROPN B-AC
+under ADP O
+the DET O
+control NOUN O
+of ADP O
+MERVL PROPN B-AC
+5′UTR PROPN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Spatial ADJ O
+distribution NOUN O
+of ADP O
+young ADJ O
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+- PUNCT O
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+male NOUN O
+- PUNCT O
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+genes NOUN O
+. PUNCT O
+“ PUNCT O
+Coordinate ADJ O
+” PUNCT O
+column NOUN O
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+the DET O
+position NOUN O
+for ADP O
+the DET O
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+point NOUN O
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+each DET O
+gene NOUN O
+. PUNCT O
+“ PUNCT O
+CT PROPN B-AC
+” PUNCT O
+marks VERB O
+whether SCONJ O
+a DET O
+gene NOUN O
+is AUX O
+a DET O
+Cancer PROPN B-LF
+/ SYM I-LF
+Testis PROPN I-LF
+gene NOUN O
+or CCONJ O
+not PART O
+according VERB O
+to ADP O
+the DET O
+CTdatabase PROPN O
+76 NUM O
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+CoA NOUN B-AC
+, PUNCT O
+coenzyme NOUN B-LF
+A. NOUN I-LF
+
+Furthermore ADV O
+, PUNCT O
+the DET O
+Diagnostic PROPN B-LF
+and CCONJ I-LF
+Statistical PROPN I-LF
+Manual PROPN I-LF
+of ADP I-LF
+Mental PROPN I-LF
+Disorders-5 PROPN I-LF
+( PUNCT O
+DSM-5 PROPN B-AC
+) PUNCT O
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+to PART O
+diagnose VERB O
+ADHD PROPN B-AC
+categorically ADV O
+. PUNCT O
+
+By ADP O
+employing VERB O
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+cloning NOUN O
+techniques NOUN O
+and CCONJ O
+vectors NOUN O
+, PUNCT O
+paired VERB O
+- PUNCT O
+end NOUN O
+diTags NOUN O
+( PUNCT O
+PETs NOUN B-AC
+) PUNCT O
+from ADP O
+ends NOUN O
+of ADP O
+transcripts NOUN O
+and CCONJ O
+this DET O
+gene NOUN B-LF
+identification NOUN I-LF
+signature NOUN I-LF
+( PUNCT O
+GIS PROPN B-AC
+) PUNCT O
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+be AUX O
+sequenced VERB O
+and CCONJ O
+mapped VERB O
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+the DET O
+genome NOUN O
+[ PUNCT O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+VE PROPN B-AC
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+all DET O
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+clinical ADJ O
+end NOUN O
+points NOUN O
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+estimated VERB O
+as ADP O
+a DET O
+relative ADJ B-LF
+risk NOUN I-LF
+( PUNCT O
+RR NOUN B-AC
+) PUNCT O
+reduction NOUN O
+with ADP O
+Fisher PROPN O
+'s PART O
+exact ADJ O
+p NOUN O
+- PUNCT O
+values NOUN O
+. PUNCT O
+
+HOMA PROPN B-AC
+- PUNCT B-AC
+IR PROPN B-AC
+= PUNCT O
+homeostasis NOUN B-LF
+model NOUN I-LF
+assessment NOUN I-LF
+insulin NOUN I-LF
+resistance NOUN I-LF
+
+Accumulating VERB O
+evidence NOUN O
+has AUX O
+shown VERB O
+that SCONJ O
+exposure NOUN O
+to ADP O
+environmental ADJ B-LF
+tobacco NOUN I-LF
+smoke NOUN I-LF
+( PUNCT O
+ETS PROPN B-AC
+) PUNCT O
+is AUX O
+associated VERB O
+with ADP O
+cardiovascular ADJ B-LF
+diseases NOUN I-LF
+( PUNCT O
+CVDs NOUN B-AC
+) PUNCT O
+However ADV O
+, PUNCT O
+few ADJ O
+studies NOUN O
+have AUX O
+assessed VERB O
+both DET O
+exposure NOUN O
+to ADP O
+ETS PROPN B-AC
+and CCONJ O
+high ADV O
+- PUNCT O
+perceived ADJ O
+work NOUN O
+stress NOUN O
+on ADP O
+hyperlipidemia NOUN O
+. PUNCT O
+
+DWI NOUN B-AC
+= PUNCT O
+diffusion NOUN B-LF
+- PUNCT I-LF
+weighted VERB I-LF
+imaging NOUN I-LF
+, PUNCT O
+PPV NOUN O
+= PUNCT O
+positive ADJ O
+predictive ADJ O
+value NOUN O
+, PUNCT O
+NPV NOUN O
+= PUNCT O
+negative ADJ O
+predictive ADJ O
+value NOUN O
+
+Lastly ADV O
+, PUNCT O
+components NOUN O
+of ADP O
+the DET O
+APC PROPN B-AC
+, PUNCT O
+a DET O
+major ADJ O
+multi ADJ O
+- ADJ O
+subunit ADJ O
+regulator NOUN O
+of ADP O
+the DET O
+cell NOUN O
+cycle NOUN O
+, PUNCT O
+are AUX O
+lost VERB O
+in ADP O
+both DET O
+lineages NOUN O
+( PUNCT O
+i.e. X O
+, PUNCT O
+CDC26 PROPN O
+and CCONJ O
+Meiotic PROPN B-LF
+Nuclear PROPN I-LF
+Divisions PROPN I-LF
+2 NUM I-LF
+[ PUNCT O
+MND2 PROPN B-AC
+] PUNCT O
+) PUNCT O
+or CCONJ O
+just ADV O
+the DET O
+FEL PROPN B-AC
+( PUNCT O
+i.e. X O
+, PUNCT O
+APC2 PROPN O
+, PUNCT O
+APC4 PROPN O
+, PUNCT O
+APC5 PROPN O
+, PUNCT O
+and CCONJ O
+Spore PROPN B-LF
+Wall PROPN I-LF
+Maturation PROPN I-LF
+1 NUM I-LF
+[ PUNCT O
+SWM1 PROPN B-AC
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+used VERB O
+a DET O
+rat NOUN O
+model NOUN O
+of ADP O
+ischemic ADJ B-LF
+- PUNCT I-LF
+reperfusion NOUN I-LF
+nerve NOUN I-LF
+injury NOUN I-LF
+( PUNCT O
+IRI PROPN B-AC
+) PUNCT O
+to PART O
+investigate VERB O
+possible ADJ O
+effects NOUN O
+of ADP O
+hepatocyte NOUN B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+( PUNCT O
+HGF PROPN B-AC
+) PUNCT O
+against ADP O
+ischemic ADJ O
+neuropathy NOUN O
+. PUNCT O
+
+CeMM PROPN B-AC
+, PUNCT O
+C. PROPN O
+elegans PROPN O
+maintenance NOUN O
+medium NOUN O
+; PUNCT O
+FFA PROPN O
+, PUNCT O
+linolenate NOUN O
+; PUNCT O
+hlh-30 NOUN B-AC
+, PUNCT O
+basic ADJ B-LF
+helix NOUN I-LF
+– PUNCT I-LF
+loop NOUN I-LF
+– PUNCT I-LF
+helix NOUN I-LF
+transcription NOUN I-LF
+factor NOUN I-LF
+30 NUM I-LF
+; PUNCT O
+hlh-30(lf NOUN B-AC
+) PUNCT O
+, PUNCT O
+loss NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+function NOUN O
+tm1978 NOUN B-AC
+mutation NOUN O
+hlh-30 NOUN B-AC
+; PUNCT O
+LPC PROPN B-AC
+, PUNCT O
+lyso NOUN B-LF
+phosphatidyl NOUN I-LF
+choline NOUN I-LF
+; PUNCT O
+SEM NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+; PUNCT O
+TCA PROPN B-AC
+, PUNCT O
+tricarboxylic ADJ B-LF
+acid NOUN I-LF
+cycle NOUN I-LF
+; PUNCT O
+α NOUN B-AC
+- PUNCT B-AC
+FFA PROPN B-AC
+, PUNCT O
+α NOUN B-LF
+- PUNCT I-LF
+linolenate NOUN I-LF
+; PUNCT O
+γ NOUN B-AC
+- PUNCT B-AC
+FFA PROPN B-AC
+, PUNCT O
+γ NOUN B-LF
+- PUNCT I-LF
+linolenate NOUN I-LF
+. PUNCT O
+
+CKD PROPN B-AC
+, PUNCT O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+creat NOUN B-AC
+- PUNCT B-AC
+cys NOUN B-AC
+, PUNCT O
+creatinine NOUN B-LF
+and CCONJ I-LF
+cystatin NOUN I-LF
+C NOUN I-LF
+; PUNCT O
+cys NOUN B-AC
+, PUNCT O
+cystatin NOUN B-LF
+C NOUN I-LF
+; PUNCT O
+DM NOUN O
+, PUNCT O
+diabetes NOUN O
+mellitus NOUN O
+; PUNCT O
+eGFR NOUN B-AC
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+GFR PROPN B-AC
+, PUNCT O
+glomerular ADJ B-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+GP PROPN B-AC
+, PUNCT O
+general ADJ B-LF
+practitioner NOUN I-LF
+; PUNCT O
+HT NOUN O
+, PUNCT O
+hypertension NOUN O
+; PUNCT O
+NICE PROPN B-AC
+, PUNCT O
+National PROPN B-LF
+Institute PROPN I-LF
+for ADP I-LF
+Health PROPN I-LF
+and CCONJ I-LF
+Care PROPN I-LF
+Excellence PROPN I-LF
+; PUNCT O
+uACR NOUN B-AC
+, PUNCT O
+urine NOUN B-LF
+albumin NOUN I-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+creatinine NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+
+Consistently ADV O
+, PUNCT O
+Nearest PROPN B-LF
+Neighbor PROPN I-LF
+Distance PROPN I-LF
+( PUNCT O
+NND PROPN B-AC
+) PUNCT O
+analysis NOUN O
+( PUNCT O
+S2 PROPN O
+Table PROPN O
+) PUNCT O
+of ADP O
+E12 PROPN O
+- PUNCT O
+P30 NOUN O
+HetCs NOUN B-AC
+showed VERB O
+a DET O
+significant ADJ O
+degree NOUN O
+of ADP O
+clustering NOUN O
+in ADP O
+both CCONJ O
+double ADJ O
+and CCONJ O
+triple ADJ O
+clones NOUN O
+, PUNCT O
+as SCONJ O
+disclosed VERB O
+by ADP O
+their PRON O
+different ADJ O
+distributions NOUN O
+as SCONJ O
+compared VERB O
+to ADP O
+random ADJ O
+distributions NOUN O
+( PUNCT O
+Fig PROPN O
+5A NUM O
+) PUNCT O
+. PUNCT O
+Interestingly ADV O
+, PUNCT O
+the DET O
+cortical ADJ O
+component NOUN O
+( PUNCT O
+BG PROPN B-AC
+and CCONJ O
+GLAs PROPN B-AC
+) PUNCT O
+was AUX O
+comparable ADJ O
+in ADP O
+triple ADJ O
+and CCONJ O
+double ADJ O
+clones NOUN O
+, PUNCT O
+suggesting VERB O
+similar ADJ O
+modalities NOUN O
+of ADP O
+cortical ADJ O
+colonization NOUN O
+and CCONJ O
+reflecting VERB O
+a DET O
+separate ADJ O
+allocation NOUN O
+of ADP O
+WMAs NOUN B-AC
+. PUNCT O
+
+ALD PROPN B-AC
+, PUNCT O
+alcoholic ADJ B-LF
+liver NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+HBV PROPN B-AC
+, PUNCT O
+hepatitis NOUN B-LF
+B NOUN I-LF
+virus NOUN I-LF
+; PUNCT O
+HCC PROPN B-AC
+, PUNCT O
+hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+; PUNCT O
+HCV PROPN B-AC
+, PUNCT O
+hepatitis NOUN B-LF
+C NOUN I-LF
+virus NOUN I-LF
+; PUNCT O
+NAFLD PROPN B-AC
+, PUNCT O
+non ADJ O
+- ADJ O
+alcoholic ADJ O
+fatty ADJ O
+liver NOUN O
+disease NOUN O
+. PUNCT O
+
+AIP PROPN B-AC
+Atherogenic ADJ B-LF
+index NOUN I-LF
+of ADP I-LF
+plasma NOUN I-LF
+, PUNCT O
+β NOUN B-AC
+- PUNCT B-AC
+TM NOUN B-AC
+thalassemia NOUN O
+major ADJ O
+, PUNCT O
+hcy NOUN O
+homocysteine NOUN O
+, PUNCT O
+HDL NOUN B-AC
+- PUNCT B-AC
+C NOUN B-AC
+high ADJ B-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+- PUNCT I-LF
+cholesterol NOUN I-LF
+, PUNCT O
+LDL NOUN B-AC
+- PUNCT B-AC
+C NOUN B-AC
+low ADJ B-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+- PUNCT I-LF
+cholesterol NOUN I-LF
+, PUNCT O
+MDA PROPN B-AC
+malondialdehyde NOUN B-LF
+, PUNCT O
+oxLDL NOUN O
+oxidized VERB O
+low ADJ O
+density NOUN O
+lipoprotein NOUN O
+, PUNCT O
+TAC PROPN B-AC
+total ADJ B-LF
+antioxidant ADJ I-LF
+capacity NOUN I-LF
+, PUNCT O
+TC PROPN B-AC
+total ADJ B-LF
+cholesterol NOUN I-LF
+, PUNCT O
+TG NOUN B-AC
+triglycerides NOUN B-LF
+, PUNCT O
+total ADJ O
+NOx PROPN O
+total ADJ O
+nitric NOUN O
+oxide NOUN O
+. PUNCT O
+
+Sexual ADJ O
+identity NOUN O
+is AUX O
+governed VERB O
+by ADP O
+sex NOUN O
+chromosomes NOUN O
+in ADP O
+plants NOUN O
+and CCONJ O
+animals NOUN O
+, PUNCT O
+and CCONJ O
+by ADP O
+mating NOUN B-LF
+type NOUN I-LF
+( PUNCT O
+MAT PROPN B-AC
+) PUNCT O
+loci NOUN O
+in ADP O
+fungi NOUN O
+. PUNCT O
+
+CDS PROPN B-AC
+, PUNCT O
+coding VERB B-LF
+DNA NOUN I-LF
+sequence NOUN I-LF
+; PUNCT O
+RPKM PROPN B-AC
+, PUNCT O
+reads NOUN B-LF
+per ADP I-LF
+kilobase NOUN I-LF
+of ADP I-LF
+transcript NOUN I-LF
+per ADP I-LF
+million NUM I-LF
+mapped VERB I-LF
+reads NOUN I-LF
+; PUNCT O
+TE NOUN B-AC
+, PUNCT O
+translational ADJ B-LF
+efficiency NOUN I-LF
+; PUNCT O
+UTR NOUN B-AC
+, PUNCT O
+untranslated VERB B-LF
+region NOUN I-LF
+. PUNCT O
+
+Mass ADJ O
+spectrometric ADJ O
+analysis NOUN O
+of ADP O
+TlpD PROPN B-AC
+was AUX O
+performed VERB O
+as ADP O
+a DET O
+service NOUN O
+by ADP O
+Dr. PROPN O
+Larry PROPN O
+David PROPN O
+at ADP O
+Oregon PROPN B-LF
+Health PROPN I-LF
+and CCONJ I-LF
+Science PROPN I-LF
+University PROPN I-LF
+’s PART O
+( PUNCT O
+OHSU PROPN B-AC
+) PUNCT O
+Proteomics PROPN O
+Shared PROPN O
+Resource PROPN O
+Facility PROPN O
+. PUNCT O
+
+The DET O
+following ADJ O
+clinical ADJ O
+features NOUN O
+and CCONJ O
+biochemistry NOUN O
+were AUX O
+collected VERB O
+for ADP O
+analysis NOUN O
+: PUNCT O
+age NOUN O
+, PUNCT O
+sex NOUN O
+, PUNCT O
+diabetes NOUN B-LF
+mellitus NOUN I-LF
+( PUNCT O
+DM PROPN B-AC
+) PUNCT O
+status NOUN O
+, PUNCT O
+Barcelona PROPN B-LF
+Clinic PROPN I-LF
+Liver PROPN I-LF
+Cancer PROPN I-LF
+( PUNCT O
+BCLC PROPN B-AC
+) PUNCT O
+stage NOUN O
+, PUNCT O
+Child PROPN O
+- PUNCT O
+Pugh PROPN O
+score NOUN O
+, PUNCT O
+serum ADJ O
+AFP NOUN B-AC
+, PUNCT O
+alanine NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+, PUNCT O
+aspartate NOUN B-LF
+aminotransferase NOUN I-LF
+( PUNCT O
+AST PROPN B-AC
+) PUNCT O
+, PUNCT O
+creatinine NOUN O
+, PUNCT O
+albumin NOUN O
+, PUNCT O
+total ADJ O
+bilirubin NOUN O
+levels NOUN O
+, PUNCT O
+platelet NOUN O
+count NOUN O
+, PUNCT O
+and CCONJ O
+prothrombin NOUN O
+time NOUN O
+( PUNCT O
+measured VERB O
+by ADP O
+international ADJ B-LF
+normalized ADJ I-LF
+ratio NOUN I-LF
+[ PUNCT O
+INR PROPN B-AC
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Five NUM O
+of ADP O
+these DET O
+herds NOUN O
+, PUNCT O
+namely ADV O
+Castle PROPN O
+- ADJ O
+Carbondale PROPN O
+( PUNCT O
+CC PROPN B-AC
+) PUNCT O
+, PUNCT O
+Beauvais PROPN O
+Lake PROPN O
+( PUNCT O
+BL PROPN B-AC
+) PUNCT O
+, PUNCT O
+Livingstone PROPN O
+( PUNCT O
+L PROPN O
+) PUNCT O
+, PUNCT O
+Whaleback PROPN O
+( PUNCT O
+WH PROPN B-AC
+) PUNCT O
+and CCONJ O
+Porcupine PROPN B-LF
+Hills PROPN I-LF
+( PUNCT O
+PH PROPN B-AC
+) PUNCT O
+, PUNCT O
+were AUX O
+in ADP O
+areas NOUN O
+of ADP O
+high ADJ O
+cattle NOUN O
+density NOUN O
+( PUNCT O
+‘ PUNCT O
+exposed ADJ O
+’ PUNCT O
+herds NOUN O
+) PUNCT O
+, PUNCT O
+while SCONJ O
+the DET O
+other ADJ O
+five NUM O
+, PUNCT O
+namely ADV O
+Jasper PROPN B-LF
+National PROPN I-LF
+Park PROPN I-LF
+( PUNCT O
+JNP PROPN B-AC
+) PUNCT O
+, PUNCT O
+Ya PROPN B-LF
+Ha PROPN I-LF
+Tinda PROPN I-LF
+( PUNCT O
+YHT PROPN B-AC
+) PUNCT O
+, PUNCT O
+Banff PROPN B-LF
+National PROPN I-LF
+Park PROPN I-LF
+( PUNCT O
+BNP PROPN B-AC
+) PUNCT O
+, PUNCT O
+Crowsnest PROPN B-LF
+Pass PROPN I-LF
+( PUNCT O
+CP PROPN B-AC
+) PUNCT O
+, PUNCT O
+Waterton PROPN B-LF
+National PROPN I-LF
+Park PROPN I-LF
+( PUNCT O
+WNP PROPN B-AC
+) PUNCT O
+, PUNCT O
+had VERB O
+no PRON O
+or CCONJ O
+limited ADJ O
+contact NOUN O
+with ADP O
+cattle NOUN O
+( PUNCT O
+‘ PUNCT O
+non ADJ O
+- ADJ O
+exposed ADJ O
+herds NOUN O
+) PUNCT O
+( PUNCT O
+Table PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+Undernutrition NOUN O
+in ADP O
+children NOUN O
+remains VERB O
+a DET O
+major ADJ O
+global ADJ O
+health NOUN O
+issue NOUN O
+and CCONJ O
+the DET O
+prevalence NOUN O
+of ADP O
+undernutrition NOUN O
+in ADP O
+children NOUN O
+under ADP O
+age NOUN O
+five NUM O
+in ADP O
+the DET O
+Democratic PROPN B-LF
+Republic PROPN I-LF
+of ADP I-LF
+the DET I-LF
+Congo PROPN I-LF
+( PUNCT O
+DRC PROPN B-AC
+) PUNCT O
+is AUX O
+among ADP O
+the DET O
+highest ADJ O
+in ADP O
+the DET O
+world NOUN O
+. PUNCT O
+
+The DET O
+ts NOUN B-AC
+: NOUN O
+tv NOUN B-AC
+ratio NOUN O
+is AUX O
+not PART O
+significantly ADV O
+different ADJ O
+from ADP O
+1:2 NUM O
+, PUNCT O
+as ADV O
+would AUX O
+be AUX O
+expected VERB O
+under ADP O
+a DET O
+uniform ADJ O
+mutation NOUN O
+rate NOUN O
+( PUNCT O
+because SCONJ O
+there PRON O
+are VERB O
+twice DET O
+as ADV O
+many ADJ O
+possible ADJ O
+transversions NOUN B-LF
+) PUNCT O
+. PUNCT O
+
+All DET O
+proteins NOUN O
+in ADP O
+Escherichia PROPN O
+coli PROPN O
+were AUX O
+expressed VERB O
+in ADP O
+BL21 PROPN O
+- NOUN O
+CodonPlus PROPN O
+- NOUN O
+RP PROPN O
+competent ADJ O
+cells NOUN O
+strain NOUN O
+by ADP O
+adding VERB O
+1 NUM O
+mM NOUN O
+of ADP O
+Isopropyl-1 NOUN B-LF
+- NOUN I-LF
+thio NOUN I-LF
+- NOUN I-LF
+β NOUN I-LF
+- NOUN I-LF
+D NOUN I-LF
+- NOUN I-LF
+galactopyranoside NOUN I-LF
+( PUNCT O
+IPTG PROPN B-AC
+) PUNCT O
+and CCONJ O
+incubating VERB O
+the DET O
+culture NOUN O
+at ADP O
+200 NUM O
+rpm NOUN O
+, PUNCT O
+18 NUM O
+° NOUN O
+C NOUN O
+for ADP O
+6 NUM O
+hours NOUN O
+. PUNCT O
+
+Underlying VERB O
+data NOUN O
+are AUX O
+provided VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+αSMA PROPN B-AC
+; PUNCT O
+α NOUN O
+smooth ADJ O
+muscle NOUN O
+actin NOUN O
+; PUNCT O
+DAPI PROPN B-AC
+, PUNCT O
+4′,6 NUM B-LF
+- PUNCT I-LF
+diamidino-2 NOUN I-LF
+- PUNCT I-LF
+phenylindole NOUN I-LF
+; PUNCT O
+n.s X O
+. PUNCT O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+TGFβ1 NOUN B-AC
+, PUNCT O
+transforming VERB B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+β1 NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+CI PROPN B-AC
+, PUNCT O
+Confidence NOUN B-LF
+Interval NOUN I-LF
+; PUNCT O
+ED PROPN B-AC
+, PUNCT O
+Emergency PROPN B-LF
+Department PROPN I-LF
+; PUNCT O
+MCC PROPN O
+, PUNCT O
+Mean PROPN O
+Cumulative ADJ O
+Count NOUN O
+. PUNCT O
+
+Examples NOUN O
+of ADP O
+the DET O
+latter ADJ O
+case NOUN O
+are AUX O
+so ADV O
+- PUNCT O
+called VERB O
+“ PUNCT O
+survivors NOUN O
+” PUNCT O
+of ADP O
+telomerase NOUN O
+deletion NOUN O
+in ADP O
+Saccharomyces PROPN O
+cerevisiae NOUN O
+and CCONJ O
+alternative ADJ B-LF
+lengthening NOUN I-LF
+of ADP I-LF
+telomeres NOUN I-LF
+( PUNCT O
+ALT PROPN B-AC
+) PUNCT O
+cells NOUN O
+in ADP O
+mammals NOUN O
+[ PUNCT O
+3,4 NUM O
+] PUNCT O
+. PUNCT O
+
+AFC PROPN B-AC
+, PUNCT O
+allele NOUN B-LF
+frequency NOUN I-LF
+change NOUN I-LF
+; PUNCT O
+ASFC PROPN O
+, PUNCT O
+allele NOUN O
+- PUNCT O
+specific ADJ O
+frequency NOUN O
+change NOUN O
+; PUNCT O
+HSD PROPN B-AC
+, PUNCT O
+honest ADJ B-LF
+significant ADJ I-LF
+difference NOUN I-LF
+; PUNCT O
+RFS PROPN B-AC
+, PUNCT O
+replicate NOUN B-LF
+frequency NOUN I-LF
+spectrum NOUN I-LF
+; PUNCT O
+QT PROPN B-AC
+, PUNCT O
+quantitative ADJ O
+trait NOUN O
+. PUNCT O
+
+More ADJ O
+than ADP O
+29 NUM O
+million NUM O
+that PRON O
+is AUX O
+an DET O
+estimated VERB O
+5 NUM O
+% PUNCT O
+, PUNCT O
+under NOUN O
+- PUNCT O
+five NUM O
+children NOUN O
+suffer VERB O
+from ADP O
+severe ADJ B-LF
+acute ADJ I-LF
+malnutrition NOUN I-LF
+( PUNCT O
+SAM PROPN B-AC
+) PUNCT O
+globally ADV O
+, PUNCT O
+with ADP O
+a DET O
+nine NUM O
+times NOUN O
+higher ADJ O
+risk NOUN O
+of ADP O
+mortality NOUN O
+than ADP O
+that PRON O
+of ADP O
+well ADV O
+- PUNCT O
+nourished ADJ O
+children NOUN O
+. PUNCT O
+
+We PRON O
+employed VERB O
+three NUM O
+haplotype NOUN O
+partitioning NOUN O
+methods NOUN O
+which PRON O
+are AUX O
+confidence NOUN B-LF
+interval NOUN I-LF
+test NOUN I-LF
+( PUNCT O
+CIT PROPN B-AC
+) PUNCT O
+, PUNCT O
+four NUM B-LF
+gamete NOUN I-LF
+test NOUN I-LF
+( PUNCT O
+FGT PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+solid ADJ B-LF
+spine NOUN I-LF
+of ADP I-LF
+linkage NOUN I-LF
+disequilibrium NOUN I-LF
+( PUNCT O
+SSLD PROPN B-AC
+) PUNCT O
+. PUNCT O
+P NOUN O
+- NOUN O
+values NOUN O
+after ADP O
+stringent ADJ O
+Bonferroni PROPN O
+correction NOUN O
+for ADP O
+multiple ADJ O
+testing NOUN O
+were AUX O
+measured VERB O
+to PART O
+assess VERB O
+the DET O
+strength NOUN O
+of ADP O
+association NOUN O
+between ADP O
+the DET O
+genetic ADJ O
+variants NOUN O
+and CCONJ O
+RA PROPN B-AC
+susceptibility NOUN O
+. PUNCT O
+
+Colorectal ADJ B-LF
+cancer NOUN I-LF
+( PUNCT O
+CRC PROPN B-AC
+) PUNCT O
+is AUX O
+the DET O
+third ADV O
+most ADV O
+common ADJ O
+cancer NOUN O
+and CCONJ O
+the DET O
+fourth ADV O
+leading VERB O
+cause NOUN O
+of ADP O
+cancer NOUN O
+- PUNCT O
+related VERB O
+mortality NOUN O
+worldwide ADV O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+locally ADV B-LF
+advanced VERB I-LF
+rectal ADJ I-LF
+cancer NOUN I-LF
+( PUNCT O
+LARC PROPN B-AC
+) PUNCT O
+constitutes VERB O
+up ADP O
+to PART O
+15 NUM O
+% NOUN O
+of ADP O
+all DET O
+CRC PROPN B-AC
+cases NOUN O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+NASH PROPN B-AC
+= PUNCT O
+Nonalcoholic ADJ B-LF
+Steatohepatitis NOUN I-LF
+, PUNCT O
+NFS PROPN B-AC
+= PUNCT O
+NAFLD PROPN B-LF
+Fibrosis PROPN I-LF
+Score PROPN I-LF
+, PUNCT O
+VCTE PROPN B-AC
+= PUNCT O
+Vibration PROPN B-LF
+Controlled PROPN I-LF
+Transient PROPN I-LF
+Elastography PROPN I-LF
+
+Add VERB O
+- PUNCT O
+on ADP O
+therapy NOUN O
+refers VERB O
+to ADP O
+LABA PROPN B-AC
+, PUNCT O
+LTRA PROPN B-AC
+, PUNCT O
+theophylline NOUN O
+, PUNCT O
+or CCONJ O
+LAMA PROPN B-AC
+. PUNCT O
+ICS PROPN B-AC
+, PUNCT O
+inhaled VERB B-LF
+corticosteroid NOUN I-LF
+; PUNCT O
+LABA PROPN B-AC
+, PUNCT O
+long ADV O
+- PUNCT O
+acting VERB O
+β2 NOUN O
+- PUNCT O
+agonist NOUN O
+; PUNCT O
+LAMA PROPN B-AC
+, PUNCT O
+long ADV B-LF
+- PUNCT I-LF
+acting VERB I-LF
+muscarinic NOUN I-LF
+antagonist NOUN I-LF
+; PUNCT O
+LTRA PROPN B-AC
+, PUNCT O
+leukotriene NOUN B-LF
+receptor NOUN I-LF
+antagonist NOUN I-LF
+. PUNCT O
+
+Seven NUM O
+serum NOUN O
+groups NOUN O
+were AUX O
+assayed VERB O
+for ADP O
+growth NOUN O
+by ADP O
+72 NUM O
+- PUNCT O
+hr NOUN O
+incubation NOUN O
+and CCONJ O
+SYBR PROPN O
+assay NOUN O
+as SCONJ O
+previously ADV O
+described VERB O
+: PUNCT O
+10 NUM O
+% NOUN O
+SHS NOUN B-AC
+, PUNCT O
+10 NUM O
+% NOUN O
+SHS NOUN B-AC
++ SYM O
+DHAPPQ PROPN B-AC
+( PUNCT O
+as SCONJ O
+previously ADV O
+described VERB O
+) PUNCT O
+, PUNCT O
+10 NUM O
+% NOUN O
+SHS NOUN B-AC
++ SYM O
+10 NUM O
+% NOUN O
+water NOUN O
+, PUNCT O
+20 NUM O
+% NOUN O
+SHS NOUN B-AC
+, PUNCT O
+10 NUM O
+% NOUN O
+SHS NOUN B-AC
++ SYM O
+10 NUM O
+% NOUN O
+Kenyan ADJ O
+Adult NOUN O
+serum NOUN O
+, PUNCT O
+10 NUM O
+% NOUN O
+SHS NOUN B-AC
++ SYM O
+10 NUM O
+% NOUN O
+Kenyan ADJ O
+Pediatric ADJ O
+serum NOUN O
+, PUNCT O
+and CCONJ O
+10 NUM O
+% NOUN O
+SHS NOUN B-AC
++ SYM O
+10 NUM O
+% NOUN O
+US PROPN B-LF
+Adult NOUN I-LF
+serum NOUN O
+. PUNCT O
+
+ERK5 PROPN O
+, PUNCT O
+extracellular ADJ O
+signal NOUN O
+– PUNCT O
+regulated VERB O
+kinase PROPN O
+5 NUM O
+; PUNCT O
+ERM PROPN B-AC
+, PUNCT O
+Ezrin PROPN O
+( PUNCT O
+Thr567)/Radixin PROPN O
+( PUNCT O
+Thr564)/Moesin PROPN O
+( PUNCT O
+Thr558 NOUN O
+) PUNCT O
+; PUNCT O
+HR PROPN O
+, PUNCT O
+hazard NOUN O
+ratio NOUN O
+; PUNCT O
+IB PROPN B-AC
+, PUNCT O
+immunoblot NOUN B-LF
+; PUNCT O
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+NS PROPN O
+, PUNCT O
+not PART O
+significant ADJ O
+; PUNCT O
+NSG PROPN B-AC
+, PUNCT O
+NOD NOUN B-LF
+scid NOUN I-LF
+gamma NOUN I-LF
+; PUNCT O
+OE PROPN B-AC
+, PUNCT O
+overexpressing NOUN B-LF
+; PUNCT O
+PDCD10 PROPN B-AC
+, PUNCT O
+programmed VERB B-LF
+cell NOUN I-LF
+death NOUN I-LF
+protein NOUN I-LF
+10 NUM I-LF
+; PUNCT O
+p NOUN O
+- PUNCT O
+ERM PROPN B-AC
+, PUNCT O
+phosphorylation NOUN O
+of ADP O
+ERM PROPN B-AC
+; PUNCT O
+RhoA PROPN B-AC
+, PUNCT O
+Ras PROPN B-LF
+homolog NOUN I-LF
+family NOUN I-LF
+member NOUN I-LF
+A PROPN I-LF
+; PUNCT O
+ROCK1 PROPN O
+, PUNCT O
+Rho PROPN O
+- PUNCT O
+associated VERB O
+coiled NOUN O
+- PUNCT O
+coil NOUN O
+kinase PROPN O
+1 NUM O
+; PUNCT O
+shRNA PROPN B-AC
+, PUNCT O
+short ADJ B-LF
+hairpin NOUN I-LF
+RNA NOUN I-LF
+; PUNCT O
+TRIM59 PROPN O
+, PUNCT O
+tripartite NOUN O
+motif NOUN O
+59 NUM O
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+We PRON O
+propose VERB O
+Historical PROPN B-LF
+Information PROPN I-LF
+for ADP I-LF
+Class PROPN I-LF
+Stability PROPN I-LF
+Prediction PROPN I-LF
+( PUNCT O
+HICSP PROPN B-AC
+) PUNCT O
+, PUNCT O
+an DET O
+approach NOUN O
+to PART O
+exploit VERB O
+change NOUN O
+history NOUN O
+information NOUN O
+to PART O
+predict VERB O
+the DET O
+instable ADJ O
+classes NOUN O
+based VERB O
+on ADP O
+its PRON O
+correlation NOUN O
+with ADP O
+change NOUN O
+propagation NOUN O
+factors NOUN O
+. PUNCT O
+
+We PRON O
+determined VERB O
+the DET O
+NSAIDs PROPN B-AC
+recommended VERB O
+by ADP O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+in ADP O
+its PRON O
+Model PROPN O
+List PROPN O
+of ADP O
+Essential PROPN O
+Medicines PROPN O
+[ PUNCT O
+15 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+by ADP O
+individual ADJ O
+countries NOUN O
+with ADP O
+published VERB O
+national ADJ O
+EMLs NOUN B-AC
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+other ADJ O
+hypertensive ADJ O
+animal NOUN O
+models NOUN O
+such ADJ O
+as ADP O
+endothelial ADJ O
+NOS PROPN B-AC
+( PUNCT O
+eNOS PROPN B-AC
+) PUNCT O
+knock NOUN B-LF
+- PUNCT I-LF
+out NOUN I-LF
+( PUNCT O
+KO PROPN B-AC
+) PUNCT O
+mice NOUN O
+do AUX O
+not PART O
+have VERB O
+cardiac ADJ O
+hypertrophy NOUN O
+[ PUNCT O
+38 NUM O
+, PUNCT O
+39 NUM O
+] PUNCT O
+. PUNCT O
+
+To PART O
+assess VERB O
+our PRON O
+proposed VERB O
+new ADJ O
+method NOUN O
+, PUNCT O
+we PRON O
+performed VERB O
+simulation NOUN O
+analyses NOUN O
+to PART O
+compare VERB O
+the DET O
+relative ADJ O
+performances NOUN O
+of ADP O
+( PUNCT O
+1 X O
+) PUNCT O
+conventional ADJ O
+haplotype NOUN O
+- PUNCT O
+based VERB O
+analysis NOUN O
+using VERB O
+original ADJ O
+haplotype NOUN O
+, PUNCT O
+( PUNCT O
+2 X O
+) PUNCT O
+single ADJ O
+- PUNCT O
+locus NOUN O
+allele NOUN O
+- PUNCT O
+based VERB O
+analysis NOUN O
+, PUNCT O
+( PUNCT O
+3 X O
+) PUNCT O
+original ADJ O
+haplotype NOUN O
+cladistic ADJ O
+analysis NOUN O
+( PUNCT O
+CLADHC PROPN B-AC
+) PUNCT O
+by ADP O
+Durrant PROPN O
+et X O
+al NOUN O
+. PUNCT O
+, PUNCT O
+and CCONJ O
+( PUNCT O
+4 X O
+) PUNCT O
+our PRON O
+weighted VERB O
+haplotype NOUN B-LF
+cladistic ADJ I-LF
+analysis NOUN I-LF
+method NOUN I-LF
+, PUNCT O
+under ADP O
+different ADJ O
+scenarios NOUN O
+. PUNCT O
+
+In ADP O
+S. PROPN O
+album NOUN O
+plants NOUN O
+, PUNCT O
+santalenes NOUN O
+and CCONJ O
+bergamotene NOUN O
+can AUX O
+be AUX O
+generated VERB O
+from ADP O
+farnesyl NOUN B-LF
+diphosphate NOUN I-LF
+( PUNCT O
+FPP PROPN B-AC
+) PUNCT O
+in ADP O
+the DET O
+MVA PROPN B-AC
+pathway NOUN O
+via ADP O
+the DET O
+activity NOUN O
+of ADP O
+santalene NOUN B-LF
+synthase NOUN I-LF
+( PUNCT O
+SaSSy PROPN B-AC
+) PUNCT O
+[ X O
+23,24 NUM O
+] PUNCT O
+. PUNCT O
+
+Compared VERB O
+to ADP O
+a DET O
+cohort NOUN O
+of ADP O
+The PROPN B-LF
+Cancer PROPN I-LF
+Genome PROPN I-LF
+Atlas PROPN I-LF
+( PUNCT O
+TCGA PROPN B-AC
+) PUNCT O
+patients NOUN O
+with ADP O
+HER2 PROPN O
+- PUNCT O
+positive ADJ O
+non ADJ O
+- PUNCT O
+IBC PROPN B-AC
+, PUNCT O
+HER2 PROPN O
+- PUNCT O
+positive ADJ O
+IBC PROPN B-AC
+patients NOUN O
+had VERB O
+significantly ADV O
+higher ADJ O
+mutational ADJ O
+and CCONJ O
+neoantigenic ADJ O
+burden NOUN O
+, PUNCT O
+more ADV O
+frequent ADJ O
+gain NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+function NOUN O
+TP53 NOUN O
+mutations NOUN O
+and CCONJ O
+a DET O
+recurrent ADJ O
+11q13.5 NUM O
+amplification NOUN O
+overlapping VERB O
+PAK1 NOUN O
+. PUNCT O
+Planned ADJ O
+exploratory ADJ O
+analysis NOUN O
+revealed VERB O
+that SCONJ O
+trastuzumab NOUN O
+- PUNCT O
+naïve ADJ O
+patients NOUN O
+with ADP O
+tumours NOUN O
+harbouring VERB O
+somatic ADJ O
+activation NOUN O
+of ADP O
+PI3K PROPN O
+/ SYM O
+Akt NOUN O
+signalling NOUN O
+had VERB O
+significantly ADV O
+shorter ADJ O
+PFS PROPN B-AC
+compared VERB O
+to ADP O
+those PRON O
+without ADP O
+( PUNCT O
+p NOUN O
+= SYM O
+0.03 NUM O
+) PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+ALCAM PROPN B-AC
+, PUNCT O
+activated VERB B-LF
+leukocyte NOUN I-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+; PUNCT O
+At PROPN O
+, PUNCT O
+atria NOUN O
+; PUNCT O
+CM PROPN B-AC
+, PUNCT O
+cardiomyocyte NOUN B-LF
+; PUNCT O
+E PROPN O
+, PUNCT O
+embryonic ADJ O
+day NOUN O
+; PUNCT O
+EC PROPN B-AC
+, PUNCT O
+endothelial ADJ B-LF
+cell NOUN I-LF
+; PUNCT O
+EndoC PROPN B-AC
+, PUNCT O
+endocardial ADJ B-LF
+cell NOUN I-LF
+; PUNCT O
+EPDC PROPN B-AC
+, PUNCT O
+epicardial ADJ B-LF
+- PUNCT I-LF
+derived VERB I-LF
+cell NOUN I-LF
+; PUNCT O
+EpiC PROPN B-AC
+, PUNCT O
+epicardial ADJ B-LF
+cell NOUN I-LF
+; PUNCT O
+FB PROPN B-AC
+, PUNCT O
+fibroblast NOUN B-LF
+; PUNCT O
+Gp38 PROPN B-AC
+, PUNCT O
+glycoprotein NOUN B-LF
+38 NUM I-LF
+; PUNCT O
+GV PROPN B-AC
+- PUNCT B-AC
+AVJ PROPN B-AC
+, PUNCT O
+great ADJ B-LF
+vessels NOUN I-LF
+and CCONJ I-LF
+atrioventricular ADJ I-LF
+junction NOUN I-LF
+; PUNCT O
+HSA PROPN B-AC
+, PUNCT O
+heat NOUN B-LF
+stable ADJ I-LF
+antigen NOUN I-LF
+; PUNCT O
+MCAM PROPN B-AC
+, PUNCT O
+melanoma NOUN B-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+; PUNCT O
+PECAM-1 PROPN B-AC
+, PUNCT O
+platelet NOUN B-LF
+/ SYM I-LF
+endothelial ADJ I-LF
+cell NOUN I-LF
+adhesion NOUN I-LF
+molecule NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+PDGFrα PROPN B-AC
+, PUNCT O
+platelet NOUN B-LF
+derived VERB I-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+alpha NOUN I-LF
+; PUNCT O
+Sca-1 PROPN B-AC
+, PUNCT O
+stem NOUN B-LF
+cells NOUN I-LF
+antigen NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+SMC PROPN B-AC
+, PUNCT O
+smooth ADJ B-LF
+muscle NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+Thy1 PROPN B-AC
+, PUNCT O
+thymus NOUN B-LF
+cell NOUN I-LF
+antigen NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+Tnnt NOUN B-AC
+, PUNCT O
+troponin NOUN B-LF
+T NOUN I-LF
+; PUNCT O
+Vt NOUN O
+, PUNCT O
+ventricle ADJ O
+
+Due ADP O
+to ADP O
+the DET O
+Poisson PROPN O
+- PUNCT O
+like ADJ O
+distribution NOUN O
+of ADP O
+the DET O
+dizziness NOUN O
+episodes NOUN O
+, PUNCT O
+these DET O
+data NOUN O
+were AUX O
+contrasted VERB O
+between ADP O
+groups NOUN O
+with ADP O
+negative ADJ O
+binomial ADJ O
+regression NOUN O
+adjusting VERB O
+for ADP O
+length NOUN O
+of ADP O
+follow NOUN O
+- PUNCT O
+up NOUN O
+and CCONJ O
+the DET O
+outcome NOUN O
+presented VERB O
+as ADP O
+a DET O
+relative ADJ B-LF
+risk NOUN I-LF
+( PUNCT O
+RR NOUN B-AC
+) PUNCT O
+( PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+) PUNCT O
+. PUNCT O
+Non ADJ O
+- PUNCT O
+normally ADV O
+distributed ADJ O
+continuous ADJ O
+variables NOUN O
+were AUX O
+presented VERB O
+as ADP O
+median NOUN O
+( PUNCT O
+interquartile ADJ O
+range NOUN O
+) PUNCT O
+in ADP O
+addition NOUN O
+to ADP O
+mean NOUN O
+( PUNCT O
+SD NOUN O
+) PUNCT O
+. PUNCT O
+Between ADP O
+- PUNCT O
+group NOUN O
+comparisons NOUN O
+of ADP O
+retest NOUN O
+performance NOUN O
+for ADP O
+the DET O
+continuously ADV O
+scored VERB O
+primary ADJ O
+and CCONJ O
+secondary ADJ O
+outcome NOUN O
+measures NOUN O
+were AUX O
+made VERB O
+using VERB O
+generalized ADJ O
+linear ADJ O
+models NOUN O
+controlling VERB O
+for ADP O
+baseline ADJ O
+performance NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+: PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+. PUNCT O
+
+To PART O
+do VERB O
+so ADV O
+, PUNCT O
+we PRON O
+expressed VERB O
+green ADJ B-LF
+fluorescent NOUN I-LF
+protein NOUN I-LF
+( PUNCT O
+GFP PROPN B-AC
+) PUNCT O
+[ X O
+14 NUM O
+] X O
+or CCONJ O
+tdTomato NOUN B-LF
+( PUNCT O
+tdT NOUN B-AC
+) PUNCT O
+[ X O
+15 NUM O
+] X O
+under ADP O
+control NOUN O
+of ADP O
+the DET O
+ureA NOUN O
+promoter NOUN O
+at ADP O
+the DET O
+rdxA NOUN O
+chromosomal ADJ O
+locus NOUN O
+, PUNCT O
+generating VERB O
+Hp NOUN B-AC
+GFP PROPN B-AC
+and CCONJ O
+Hp NOUN B-AC
+tdT NOUN B-AC
+, PUNCT O
+respectively ADV O
+( PUNCT O
+S1A PROPN O
+and CCONJ O
+S1B PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+Along ADP O
+with ADP O
+other ADJ O
+diagnostic ADJ O
+tools NOUN O
+, PUNCT O
+programmed VERB B-LF
+ventricular ADJ I-LF
+stimulation NOUN I-LF
+( PUNCT O
+PVS PROPN B-AC
+) PUNCT O
+might AUX O
+also ADV O
+contribute VERB O
+to ADP O
+an DET O
+improved VERB O
+risk NOUN O
+assessment NOUN O
+in ADP O
+patients NOUN O
+with ADP O
+NIDCM PROPN B-AC
+. PUNCT O
+PVS PROPN B-AC
+demonstrated VERB O
+clinical ADJ O
+relevance NOUN O
+in ADP O
+the DET O
+risk NOUN O
+stratification NOUN O
+of ADP O
+patients NOUN O
+with ADP O
+ischemic ADJ O
+cardiomyopathy NOUN O
+[ PUNCT O
+17 NUM O
+, PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+Sasaki PROPN O
+et PROPN O
+al NOUN O
+. PUNCT O
+described VERB O
+the DET O
+application NOUN O
+of ADP O
+an DET O
+acetaldehyde NOUN B-LF
+breath NOUN I-LF
+test NOUN I-LF
+( PUNCT O
+ABT PROPN B-AC
+) PUNCT O
+to ADP O
+distinguish VERB O
+between ADP O
+ESD PROPN B-AC
+treated VERB O
+SCC PROPN O
+patients NOUN O
+and CCONJ O
+a DET O
+health NOUN O
+control NOUN O
+group NOUN O
+based VERB O
+on ADP O
+a DET O
+cut VERB O
+- PUNCT O
+off ADP O
+value NOUN O
+from ADP O
+the DET O
+previously ADV O
+published VERB O
+acetaldehyde NOUN O
+- PUNCT O
+to ADP O
+- PUNCT O
+ethanol NOUN O
+( PUNCT O
+A NOUN O
+/ SYM O
+E NOUN O
+) PUNCT O
+ratio NOUN O
+. PUNCT O
+
+The DET O
+paired VERB O
+- PUNCT O
+end NOUN O
+reads NOUN O
+generated VERB O
+from ADP O
+the DET O
+anti ADJ O
+- PUNCT O
+CENH3 ADJ B-AC
+ChIP NOUN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+dataset NOUN O
+are AUX O
+available ADJ O
+under ADP O
+the DET O
+Gene PROPN B-LF
+Expression PROPN I-LF
+Omnibus PROPN I-LF
+( PUNCT O
+GEO PROPN B-AC
+) PUNCT O
+database NOUN O
+( PUNCT O
+GSE124242 NOUN O
+) PUNCT O
+. PUNCT O
+
+Temporal ADJ O
+transcriptome NOUN O
+profiling NOUN O
+at ADP O
+different ADJ O
+repopulation NOUN O
+stages NOUN O
+revealed VERB O
+that PRON O
+adult ADJ O
+newborn ADJ O
+microglia NOUN O
+gradually ADV O
+regain VERB O
+steady ADJ O
+- NOUN O
+state NOUN O
+maturity NOUN O
+from ADP O
+an DET O
+immature ADJ O
+state NOUN O
+that PRON O
+is AUX O
+reminiscent ADJ O
+of ADP O
+the DET O
+neonatal ADJ O
+stage NOUN O
+and CCONJ O
+follow VERB O
+a DET O
+series NOUN O
+of ADP O
+maturation NOUN O
+programs NOUN O
+, PUNCT O
+including VERB O
+nuclear ADJ B-LF
+factor NOUN I-LF
+kappa NOUN I-LF
+- NOUN I-LF
+light NOUN I-LF
+- NOUN I-LF
+chain NOUN I-LF
+- NOUN I-LF
+enhancer NOUN I-LF
+of ADP I-LF
+activated ADJ I-LF
+B PROPN I-LF
+cells NOUN I-LF
+( PUNCT O
+NF PROPN B-AC
+- NOUN B-AC
+κB PROPN B-AC
+) PUNCT O
+activation NOUN O
+, PUNCT O
+interferon NOUN O
+immune ADJ O
+activation NOUN O
+, PUNCT O
+and CCONJ O
+apoptosis NOUN O
+. PUNCT O
+
+Autosomal ADJ B-LF
+recessive ADJ I-LF
+cerebellar ADJ I-LF
+ataxias NOUN I-LF
+( PUNCT O
+ARCAs PROPN B-AC
+) PUNCT O
+are AUX O
+a DET O
+large ADJ O
+group NOUN O
+of ADP O
+neurodegenerative ADJ O
+disorders NOUN O
+that PRON O
+manifest VERB O
+mainly ADV O
+in ADP O
+children NOUN O
+and CCONJ O
+young ADJ O
+adults NOUN O
+. PUNCT O
+
+It PRON O
+is AUX O
+central ADJ O
+to PART O
+efforts NOUN O
+to PART O
+control VERB O
+and CCONJ O
+eradicate VERB O
+malaria NOUN O
+, PUNCT O
+and CCONJ O
+currently ADV O
+estimated VERB O
+by ADP O
+the DET O
+entomological ADJ B-LF
+inoculation NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+EIR PROPN B-AC
+) PUNCT O
+usually ADV O
+interpreted VERB O
+as ADP O
+the DET O
+number NOUN O
+of ADP O
+infective ADJ O
+bites NOUN O
+received VERB O
+by ADP O
+an DET O
+individual NOUN O
+per ADP O
+unit NOUN O
+of ADP O
+time NOUN O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+anatomical ADJ O
+localization NOUN O
+, PUNCT O
+the DET O
+placement NOUN O
+of ADP O
+the DET O
+MRI NOUN O
+fields NOUN O
+- PUNCT O
+of ADP O
+- PUNCT O
+view NOUN O
+and CCONJ O
+slice NOUN O
+packages NOUN O
+were AUX O
+identified VERB O
+by ADP O
+making VERB O
+use NOUN O
+of ADP O
+1H NOUN O
+Rapid PROPN B-LF
+Acquisition PROPN I-LF
+with ADP I-LF
+Relaxation PROPN I-LF
+Enhancement PROPN I-LF
+( PUNCT O
+RARE PROPN B-AC
+) PUNCT O
+sequences NOUN O
+[ PUNCT O
+53 NUM O
+] PUNCT O
+. PUNCT O
+
+Hepatocellular ADJ B-LF
+carcinoma NOUN I-LF
+( PUNCT O
+HCC PROPN B-AC
+) PUNCT O
+is AUX O
+the DET O
+most ADV O
+common ADJ O
+type NOUN O
+of ADP O
+primary ADJ O
+liver NOUN O
+cancer NOUN O
+in ADP O
+adults NOUN O
+. PUNCT O
+
+The DET O
+incidence NOUN O
+Zik(n NOUN O
+) PUNCT O
+of ADP O
+new ADJ O
+infections NOUN O
+in ADP O
+age NOUN O
+group NOUN O
+i NOUN O
+and CCONJ O
+risk NOUN O
+group NOUN O
+k NOUN O
+at ADP O
+week NOUN O
+n NOUN O
+is(5)Note X O
+that SCONJ O
+the DET O
+general ADJ B-LF
+practitioner NOUN I-LF
+( PUNCT O
+GP PROPN B-AC
+) PUNCT O
+consultation NOUN O
+and CCONJ O
+swabbing NOUN O
+data NOUN O
+are AUX O
+only ADV O
+available ADJ O
+in ADP O
+five NUM O
+age NOUN O
+groups NOUN O
+. PUNCT O
+
+Cox PROPN O
+proportional ADJ O
+hazards NOUN O
+regression NOUN O
+was AUX O
+used VERB O
+to PART O
+estimate VERB O
+hazard NOUN B-LF
+ratios NOUN I-LF
+[ PUNCT O
+HRs NOUN B-AC
+] X O
+and CCONJ O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+[ PUNCT O
+CIs NOUN B-AC
+] X O
+for ADP O
+the DET O
+association NOUN O
+between ADP O
+small ADJ O
+and CCONJ O
+large ADJ O
+gestation NOUN O
+weight NOUN O
+and CCONJ O
+mortality NOUN O
+over ADP O
+time NOUN O
+, PUNCT O
+using VERB O
+attained VERB O
+age NOUN O
+( PUNCT O
+1 NUM O
+- PUNCT O
+day NOUN O
+intervals NOUN O
+) PUNCT O
+as ADP O
+the DET O
+underlying VERB O
+time NOUN O
+scale NOUN O
+in ADP O
+all DET O
+analyses NOUN O
+. PUNCT O
+
+Pulmonary ADJ O
+hypertension NOUN O
+( PUNCT O
+assessed VERB O
+with ADP O
+echocardiography NOUN O
+) PUNCT O
+also ADV O
+can AUX O
+indicate VERB O
+increased VERB O
+risk NOUN O
+of ADP O
+death NOUN O
+for ADP O
+patients NOUN O
+with ADP O
+end ADJ B-LF
+- ADJ I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD PROPN B-AC
+) PUNCT O
+[ PUNCT O
+21 NUM O
+] PUNCT O
+. PUNCT O
+
+Where SCONJ O
+breech NOUN O
+presentation NOUN O
+was AUX O
+detected VERB O
+, PUNCT O
+an DET O
+external ADJ B-LF
+cephalic NOUN I-LF
+version NOUN I-LF
+( PUNCT O
+ECV PROPN B-AC
+) PUNCT O
+was AUX O
+routinely ADV O
+offered VERB O
+. PUNCT O
+
+The DET O
+association NOUN O
+was AUX O
+interpreted VERB O
+using VERB O
+the DET O
+adjusted VERB B-LF
+odds NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+AOR PROPN B-AC
+) PUNCT O
+and CCONJ O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+’ PUNCT O
+. PUNCT O
+
+CD4 NOUN B-AC
+, PUNCT O
+cluster NOUN B-LF
+of ADP I-LF
+differentiation NOUN I-LF
+4 NUM I-LF
+. PUNCT O
+
+SD PROPN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+; PUNCT O
+TAF PROPN B-AC
+, PUNCT O
+tenofovir NOUN B-LF
+alafenamide NOUN I-LF
+; PUNCT O
+TDF PROPN B-AC
+, PUNCT O
+tenofovir NOUN B-LF
+disoproxil NOUN I-LF
+fumarate NOUN I-LF
+. PUNCT O
+* PUNCT O
+p<0.05 NUM O
+, PUNCT O
+†p<0.001 NUM O
+. PUNCT O
+
+FRET PROPN O
+, PUNCT O
+Förster PROPN O
+Resonance PROPN O
+Energy PROPN O
+Transfer PROPN O
+; PUNCT O
+gH NOUN B-AC
+/ SYM B-AC
+gL NOUN B-AC
+, PUNCT O
+glycoproteins NOUN B-LF
+H NOUN I-LF
+and CCONJ I-LF
+L NOUN I-LF
+; PUNCT O
+LBD PROPN B-AC
+, PUNCT O
+ligand NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+domain NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+Heart NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+HR NOUN B-AC
+) PUNCT O
+, PUNCT O
+velocity NOUN O
+, PUNCT O
+left ADJ B-LF
+ventricle NOUN I-LF
+( PUNCT O
+LV PROPN B-AC
+) PUNCT O
+mass NOUN O
+, PUNCT O
+LV PROPN B-LF
+internal ADJ I-LF
+diameter NOUN I-LF
+at ADP I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastole NOUN I-LF
+( PUNCT O
+LVID PROPN B-AC
+, PUNCT B-AC
+d NOUN B-AC
+) PUNCT O
+, PUNCT O
+LV PROPN B-LF
+posterior ADJ I-LF
+wall NOUN I-LF
+thickness NOUN I-LF
+at ADP I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastole NOUN I-LF
+( PUNCT O
+LVPW PROPN B-AC
+, PUNCT B-AC
+d NOUN B-AC
+) PUNCT O
+, PUNCT O
+LV PROPN B-LF
+anterior ADJ I-LF
+wall NOUN I-LF
+thickness NOUN I-LF
+at ADP I-LF
+end NOUN I-LF
+- PUNCT I-LF
+diastole NOUN I-LF
+( PUNCT O
+LVAW PROPN B-AC
+, PUNCT B-AC
+d NOUN B-AC
+) PUNCT O
+, PUNCT O
+ejection NOUN B-LF
+fraction NOUN I-LF
+( PUNCT O
+EF PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+fractional ADJ B-LF
+shortening NOUN I-LF
+( PUNCT O
+FS PROPN B-AC
+) PUNCT O
+of ADP O
+the DET O
+LV PROPN B-AC
+were AUX O
+measured VERB O
+. PUNCT O
+
+Odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+OR NOUN B-AC
+) PUNCT O
+were AUX O
+computed VERB O
+to PART O
+determine VERB O
+of ADP O
+associations NOUN O
+between ADP O
+variables NOUN O
+at ADP O
+95 NUM O
+% NOUN O
+Confidence NOUN B-LF
+Intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+. PUNCT O
+
+For ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+excluded VERB O
+the DET O
+respondents NOUN O
+where SCONJ O
+the DET O
+outcome NOUN O
+variable NOUN O
+( PUNCT O
+place NOUN O
+of ADP O
+delivery NOUN O
+) PUNCT O
+was AUX O
+missed VERB O
+and CCONJ O
+for ADP O
+the DET O
+spatial ADJ O
+analysis NOUN O
+, PUNCT O
+we PRON O
+excluded VERB O
+those DET O
+women NOUN O
+in ADP O
+the DET O
+Enumeration PROPN B-LF
+Areas PROPN I-LF
+( PUNCT O
+EAs PROPN B-AC
+) PUNCT O
+with ADP O
+zero NUM O
+latitudes NOUN O
+and CCONJ O
+longitude NOUN O
+. PUNCT O
+
+The DET O
+waist NOUN B-LF
+circumference NOUN I-LF
+( PUNCT O
+WC NOUN B-AC
+, PUNCT O
+cm NOUN O
+) PUNCT O
+was AUX O
+measured VERB O
+midway ADV O
+between ADP O
+the DET O
+costal ADJ O
+margin NOUN O
+and CCONJ O
+the DET O
+iliac ADJ O
+crest NOUN O
+at ADP O
+the DET O
+end NOUN O
+of ADP O
+a DET O
+normal ADJ O
+expiration NOUN O
+. PUNCT O
+
+The DET O
+sample NOUN O
+size NOUN O
+calculation NOUN O
+assumed VERB O
+that SCONJ O
+40 NUM O
+% PUNCT O
+of ADP O
+participants NOUN O
+would AUX O
+have VERB O
+well ADV O
+- PUNCT O
+controlled VERB O
+HbA1c NOUN B-AC
+( PUNCT O
+< PUNCT O
+7 NUM O
+% PUNCT O
+) PUNCT O
+at ADP O
+EOS PROPN B-AC
+in ADP O
+the DET O
+control NOUN O
+group NOUN O
+, PUNCT O
+with ADP O
+an DET O
+intraclass NOUN B-LF
+correlation NOUN I-LF
+coefficient NOUN I-LF
+( PUNCT O
+ICC NOUN B-AC
+) PUNCT O
+of ADP O
+0.15 NUM O
+. PUNCT O
+
+KO PROPN B-AC
+, PUNCT O
+knockout NOUN B-LF
+; PUNCT O
+SG PROPN B-AC
+, PUNCT O
+slow ADJ B-LF
+gamma NOUN I-LF
+. PUNCT O
+
+Peripheral ADJ B-LF
+Blood NOUN I-LF
+mononuclear ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+PBMC PROPN B-AC
+) PUNCT O
+were AUX O
+isolated VERB O
+using VERB O
+Ficoll PROPN O
+- PUNCT O
+Paque PROPN O
+density NOUN O
+gradient NOUN O
+centrifugation NOUN O
+and CCONJ O
+samples NOUN O
+were AUX O
+stored VERB O
+in ADP O
+fetal ADJ O
+bovine ADJ O
+serum NOUN O
+( PUNCT O
+FBS PROPN O
+) PUNCT O
+( PUNCT O
+Biowest PROPN O
+) PUNCT O
+supplemented VERB O
+with ADP O
+10 NUM O
+% NOUN O
+DMSO PROPN O
+( PUNCT O
+Sigma PROPN O
+- PUNCT O
+Aldrich PROPN O
+) PUNCT O
+at ADP O
+-150 NUM O
+° NOUN O
+C NOUN O
+. PUNCT O
+
+While SCONJ O
+, PUNCT O
+since SCONJ O
+the DET O
+beginning NOUN O
+of ADP O
+Highly ADV O
+Active PROPN O
+Antiretroviral PROPN O
+Therapy(HAART PROPN B-AC
+) PUNCT O
+has VERB O
+made VERB O
+great ADJ O
+progress NOUN O
+in ADP O
+improving VERB O
+the DET O
+longevity NOUN O
+and CCONJ O
+quality NOUN O
+of ADP O
+life NOUN O
+of ADP O
+people NOUN B-LF
+living VERB I-LF
+with ADP I-LF
+HIV PROPN I-LF
+( PUNCT O
+PLWHIV PROPN B-AC
+) PUNCT O
+, PUNCT O
+treatment NOUN O
+is AUX O
+not PART O
+risk NOUN O
+- PUNCT O
+free ADJ O
+or CCONJ O
+has VERB O
+side NOUN O
+effects NOUN O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+we PRON O
+engineered VERB O
+a DET O
+retrovirus NOUN O
+to PART O
+express VERB O
+the DET O
+oligomerization NOUN B-LF
+domain NOUN I-LF
+of ADP I-LF
+p53 NOUN I-LF
+( PUNCT O
+DDp53 NOUN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+also ADV O
+inhibits VERB O
+p53 NOUN O
+activity NOUN O
+[ X O
+26 NUM O
+] PUNCT O
+. PUNCT O
+
+DiI PROPN B-AC
+, PUNCT O
+1,19 NUM B-LF
+- PUNCT I-LF
+dioctadecyl-3,3,39,39 NOUN I-LF
+- PUNCT I-LF
+tetramethylindocarbocyanine NOUN I-LF
+perchlorate NOUN I-LF
+; PUNCT O
+WGA PROPN B-AC
+, PUNCT O
+wheat NOUN B-LF
+germ NOUN I-LF
+agglutinin NOUN I-LF
+. PUNCT O
+
+Each DET O
+imperfect ADJ O
+tandem NOUN O
+repeat NOUN O
+encodes VERB O
+50–53 NUM O
+amino NOUN O
+acid NOUN O
+residues NOUN O
+and CCONJ O
+contains VERB O
+three NUM O
+α NOUN O
+- PUNCT O
+helices NOUN O
+, PUNCT O
+the DET O
+second ADJ O
+and CCONJ O
+third ADJ O
+of ADP O
+which PRON O
+form VERB O
+a DET O
+helix NOUN B-LF
+- PUNCT I-LF
+turn NOUN I-LF
+- PUNCT I-LF
+helix NOUN I-LF
+( PUNCT O
+HTH PROPN B-AC
+) PUNCT O
+motif NOUN O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+. PUNCT O
+
+Today NOUN O
+'s PART O
+TB PROPN B-AC
+treatment NOUN O
+, PUNCT O
+which PRON O
+dates VERB O
+back ADV O
+to ADP O
+the DET O
+1970s NOUN O
+, PUNCT O
+is AUX O
+long ADJ O
+and CCONJ O
+burdensome ADJ O
+, PUNCT O
+requiring VERB O
+at ADV O
+least ADV O
+6 NUM O
+mo NOUN O
+of ADP O
+multidrug NOUN O
+chemotherapy NOUN O
+, PUNCT O
+typically ADV O
+consisting VERB O
+of ADP O
+rifampicin NOUN B-LF
+( PUNCT O
+RFP PROPN B-AC
+) PUNCT O
+, PUNCT O
+isoniazid NOUN B-LF
+( PUNCT O
+INH PROPN B-AC
+) PUNCT O
+, PUNCT O
+ethambutol NOUN B-LF
+( PUNCT O
+EB PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+pyrazinamide NOUN B-LF
+( PUNCT O
+PZA PROPN B-AC
+) PUNCT O
+given VERB O
+under ADP O
+clinically ADV O
+observed ADJ O
+conditions NOUN O
+. PUNCT O
+
+ICS PROPN B-AC
+, PUNCT O
+inhaled VERB B-LF
+corticosteroid NOUN I-LF
+
+The DET O
+diagnosis NOUN O
+of ADP O
+HCC PROPN B-AC
+was AUX O
+confirmed VERB O
+based VERB O
+on ADP O
+HCC PROPN B-AC
+management NOUN O
+guidelines NOUN O
+from ADP O
+EASL PROPN B-AC
+or CCONJ O
+AASLD.[2 PROPN B-AC
+, PUNCT O
+3 NUM O
+] PUNCT O
+Performance NOUN O
+status NOUN O
+was AUX O
+determined VERB O
+when SCONJ O
+HCC PROPN B-AC
+diagnosis NOUN O
+was AUX O
+made.[14 VERB O
+] PUNCT O
+Total ADJ B-LF
+tumor NOUN I-LF
+volume NOUN I-LF
+( PUNCT O
+TTV PROPN B-AC
+) PUNCT O
+was AUX O
+calculated VERB O
+based VERB O
+on ADP O
+tumor NOUN O
+diameter.[15 NOUN O
+] PUNCT O
+Patients NOUN O
+were AUX O
+censored VERB O
+at ADP O
+time NOUN O
+of ADP O
+liver NOUN O
+transplantation NOUN O
+if SCONJ O
+they PRON O
+received VERB O
+transplantation NOUN O
+as ADP O
+salvage NOUN O
+therapy NOUN O
+. PUNCT O
+
+The DET O
+letters NOUN O
+indicate VERB O
+the DET O
+corresponding ADJ O
+values NOUN O
+for ADP O
+the DET O
+samples NOUN O
+in ADP O
+panels NOUN O
+( PUNCT O
+A NOUN O
+– SYM O
+D NOUN O
+) PUNCT O
+for ADP O
+comparison NOUN O
+. PUNCT O
+( PUNCT O
+F X O
+) PUNCT O
+The DET O
+distribution NOUN O
+of ADP O
+quasi ADJ B-LF
+- ADJ I-LF
+phaseable ADJ I-LF
+( PUNCT O
+QP PROPN B-AC
+) PUNCT O
+samples NOUN O
+among ADP O
+the DET O
+35 NUM O
+most ADV O
+prevalent ADJ O
+species NOUN O
+, PUNCT O
+arranged VERB O
+by ADP O
+descending VERB O
+prevalence NOUN O
+; PUNCT O
+the DET O
+distribution NOUN O
+across ADP O
+hosts NOUN O
+is AUX O
+shown VERB O
+in ADP O
+S7 PROPN O
+Fig NOUN O
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+consider VERB O
+3 NUM O
+factors NOUN O
+that PRON O
+could AUX O
+plausibly ADV O
+modulate VERB O
+the DET O
+risk NOUN O
+reduction NOUN O
+effectiveness NOUN O
+of ADP O
+weight NOUN O
+loss NOUN O
+: PUNCT O
+initial ADJ O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+, PUNCT O
+defined VERB O
+as ADP O
+weight NOUN O
+in ADP O
+kilograms NOUN O
+divided VERB O
+by ADP O
+squared VERB O
+height NOUN O
+in ADP O
+meters NOUN O
+) PUNCT O
+, PUNCT O
+family NOUN O
+history NOUN O
+( PUNCT O
+whether SCONJ O
+a DET O
+mother NOUN O
+, PUNCT O
+father NOUN O
+, PUNCT O
+or CCONJ O
+sibling NOUN O
+has VERB O
+diabetes NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+genetic ADJ O
+risk NOUN O
+according VERB O
+to ADP O
+a DET O
+polygenic ADJ O
+risk NOUN O
+score NOUN O
+constructed VERB O
+from ADP O
+over ADP O
+100,000 NUM O
+DNA NOUN O
+sequence NOUN O
+polymorphisms NOUN O
+based VERB O
+on ADP O
+their PRON O
+association NOUN O
+with ADP O
+type NOUN O
+2 NUM O
+diabetes NOUN O
+in ADP O
+a DET O
+recent ADJ O
+genome NOUN O
+- PUNCT O
+wide ADJ O
+association NOUN O
+study NOUN O
+[ PUNCT O
+14 NUM O
+] PUNCT O
+. PUNCT O
+
+Non ADJ B-LF
+- ADJ I-LF
+alcoholic ADJ I-LF
+fatty ADJ I-LF
+liver NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+NAFLD PROPN B-AC
+) PUNCT O
+is AUX O
+increasingly ADV O
+common ADJ O
+in ADP O
+the DET O
+adult NOUN O
+population NOUN O
+. PUNCT O
+
+For ADP O
+the DET O
+logit NOUN O
+and CCONJ O
+negative ADJ O
+binomial ADJ O
+models NOUN O
+, PUNCT O
+the DET O
+interaction NOUN O
+terms NOUN O
+are AUX O
+not PART O
+relative ADJ B-LF
+risks NOUN I-LF
+( PUNCT O
+RRs NOUN B-AC
+) PUNCT O
+or CCONJ O
+odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+ORs NOUN B-AC
+) PUNCT O
+per X O
+se X O
+, PUNCT O
+but CCONJ O
+rather ADV O
+are AUX O
+the DET O
+post ADJ O
+- NOUN O
+intervention NOUN O
+ratios NOUN O
+divided VERB O
+by ADP O
+the DET O
+pre ADJ O
+- NOUN O
+intervention NOUN O
+ratios NOUN O
+: PUNCT O
+a DET O
+result NOUN O
+less ADJ O
+than ADP O
+one NUM O
+indicates VERB O
+positive ADJ O
+intervention NOUN O
+effectiveness NOUN O
+. PUNCT O
+
+The DET O
+key ADJ O
+enzymes NOUN O
+in ADP O
+the DET O
+MVA PROPN O
+pathway NOUN O
+mainly ADV O
+include VERB O
+HMGS PROPN B-AC
+( PUNCT O
+3 NUM B-LF
+- NOUN I-LF
+hydroxy-3 NOUN I-LF
+- NOUN I-LF
+methylglutaryl NOUN I-LF
+CoA NOUN I-LF
+synthase NOUN I-LF
+) PUNCT O
+, PUNCT O
+HMGR PROPN B-AC
+( PUNCT O
+3 NUM B-LF
+- NOUN I-LF
+hydroxy-3 NOUN I-LF
+- NOUN I-LF
+methyl NOUN I-LF
+glutaryl NOUN I-LF
+CoA NOUN I-LF
+reductase NOUN I-LF
+) PUNCT O
+, PUNCT O
+MK PROPN B-AC
+( PUNCT O
+mevalonate NOUN B-LF
+kinase NOUN I-LF
+) PUNCT O
+, PUNCT O
+FPPS PROPN B-AC
+( PUNCT O
+farnesyl NOUN B-LF
+diphosphate NOUN I-LF
+synthase NOUN I-LF
+) PUNCT O
+and CCONJ O
+SS PROPN B-AC
+( PUNCT O
+squalene NOUN B-LF
+synthase NOUN I-LF
+) PUNCT O
+( PUNCT O
+Fig NOUN O
+6 NUM O
+) PUNCT O
+. PUNCT O
+
+Prognostic ADJ O
+factors NOUN O
+were AUX O
+identified VERB O
+using VERB O
+the DET O
+least ADJ B-LF
+absolute ADJ I-LF
+shrinkage NOUN I-LF
+and CCONJ I-LF
+selection NOUN I-LF
+operator NOUN I-LF
+( PUNCT O
+LASSO)-based PROPN B-AC
+normal ADJ B-LF
+tissue NOUN I-LF
+complication NOUN I-LF
+probability NOUN I-LF
+( PUNCT O
+NTCP PROPN B-AC
+) PUNCT O
+model NOUN O
+. PUNCT O
+
+For ADP O
+susceptible ADJ O
+patients NOUN O
+, PUNCT O
+1 NUM O
+day NOUN O
+in ADP O
+the DET O
+same ADJ O
+ward NOUN O
+with ADP O
+another DET O
+patient NOUN O
+with ADP O
+hospital NOUN O
+- PUNCT O
+acquired VERB O
+SARS PROPN B-AC
+- PUNCT B-AC
+CoV-2 PROPN B-AC
+was AUX O
+associated VERB O
+with ADP O
+an DET O
+additional ADJ O
+7.5 NUM O
+infections NOUN O
+per ADP O
+1,000 NUM O
+susceptible ADJ O
+patients NOUN O
+( PUNCT O
+95 NUM O
+% NOUN O
+credible ADJ B-LF
+interval NOUN I-LF
+( PUNCT O
+CrI PROPN B-AC
+) PUNCT O
+5.5 NUM O
+to PART O
+9.5/1,000 NUM O
+susceptible ADJ O
+patients NOUN O
+/ SYM O
+day NOUN O
+) PUNCT O
+per ADP O
+day NOUN O
+. PUNCT O
+
+We PRON O
+assessed VERB O
+the DET O
+quality NOUN O
+of ADP O
+evidence NOUN O
+for ADP O
+each DET O
+outcome NOUN O
+using VERB O
+Grading PROPN B-LF
+of ADP I-LF
+Recommendations PROPN I-LF
+Assessment PROPN I-LF
+, PUNCT I-LF
+Development PROPN I-LF
+and CCONJ I-LF
+Evaluation PROPN I-LF
+( PUNCT O
+GRADE PROPN B-AC
+) PUNCT O
+criteria NOUN O
+, PUNCT O
+and CCONJ O
+these DET O
+results NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Table PROPN O
+[ PUNCT O
+22 NUM O
+] PUNCT O
+. PUNCT O
+
+Dyslipidemia NOUN O
+was AUX O
+defined VERB O
+as ADP O
+a DET O
+total ADJ B-LF
+cholesterol NOUN I-LF
+( PUNCT O
+TC PROPN B-AC
+) PUNCT O
+level NOUN O
+≥220 NUM O
+mg NOUN O
+/ SYM O
+dL NOUN O
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+- PUNCT I-LF
+cholesterol NOUN I-LF
+( PUNCT O
+LDL NOUN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+) PUNCT O
+level NOUN O
+≥140 NUM O
+mg NOUN O
+/ SYM O
+dL NOUN O
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+lipoprotein NOUN I-LF
+- PUNCT I-LF
+cholesterol NOUN I-LF
+( PUNCT O
+HDL PROPN B-AC
+- PUNCT B-AC
+C PROPN B-AC
+) PUNCT O
+level NOUN O
+< ADJ O
+40 NUM O
+mg NOUN O
+/ SYM O
+dL NOUN O
+, PUNCT O
+or CCONJ O
+the DET O
+current ADJ O
+use NOUN O
+of ADP O
+lipid NOUN O
+- PUNCT O
+lowering VERB O
+agents NOUN O
+. PUNCT O
+
+Studies NOUN O
+that PRON O
+reported VERB O
+a DET O
+treatment NOUN O
+success NOUN O
+rate NOUN O
+over ADP O
+70 NUM O
+% NOUN O
+showed VERB O
+a DET O
+trend NOUN O
+toward ADP O
+a DET O
+better ADJ O
+improvement NOUN O
+in ADP O
+the DET O
+PCS PROPN B-AC
+( PUNCT O
+A NOUN O
+) PUNCT O
+and CCONJ O
+a DET O
+significantly ADV O
+better ADJ O
+improvement NOUN O
+in ADP O
+the DET O
+MCS PROPN B-AC
+( PUNCT O
+B NOUN O
+) PUNCT O
+. PUNCT O
+CI NOUN O
+: PUNCT O
+confidence NOUN O
+intervals NOUN O
+; PUNCT O
+MCS PROPN B-AC
+: PUNCT O
+mental ADJ B-LF
+component NOUN I-LF
+summary NOUN I-LF
+score NOUN I-LF
+; PUNCT O
+PCS PROPN B-AC
+: PUNCT O
+physical ADJ B-LF
+component NOUN I-LF
+summary NOUN I-LF
+score NOUN I-LF
+; PUNCT O
+RFCA NOUN B-AC
+: PUNCT O
+radiofrequency NOUN B-LF
+catheter NOUN I-LF
+ablation NOUN I-LF
+. PUNCT O
+
+This DET O
+table NOUN O
+lists VERB O
+the DET O
+human ADJ O
+qPCR NOUN B-AC
+primers NOUN O
+. PUNCT O
+qPCR NOUN B-AC
+, PUNCT O
+quantitative ADJ B-LF
+PCR NOUN I-LF
+. PUNCT O
+
+Tracheobronchial ADJ O
+basal ADJ O
+cells NOUN O
+proliferating VERB O
+on ADP O
+plastic NOUN O
+were AUX O
+infected VERB O
+with SCONJ O
+Lenti PROPN O
+- PUNCT O
+SOX2 PROPN O
+or CCONJ O
+empty ADJ O
+vector NOUN O
+, PUNCT O
+with SCONJ O
+mean NOUN O
+expression NOUN O
+± SYM O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+( PUNCT O
+SEM PROPN B-AC
+) PUNCT O
+from ADP O
+three NUM O
+biological ADJ O
+replicate NOUN O
+experiments NOUN O
+shown VERB O
+. PUNCT O
+
+ENSANUT PROPN B-AC
+, PUNCT O
+Encuesta PROPN B-LF
+Nacional PROPN I-LF
+de ADP I-LF
+Salud PROPN I-LF
+y CCONJ I-LF
+Nutrición PROPN I-LF
+; PUNCT O
+SE PROPN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+; PUNCT O
+SSB PROPN B-AC
+, PUNCT O
+sugar NOUN B-LF
+- PUNCT I-LF
+sweetened VERB I-LF
+beverage NOUN I-LF
+. PUNCT O
+
+Dˊ NOUN B-AC
+( PUNCT O
+normalized VERB B-LF
+deviation NOUN I-LF
+) PUNCT O
+is AUX O
+used VERB O
+to PART O
+measure VERB O
+the DET O
+LD NOUN B-AC
+between ADP O
+a DET O
+pair NOUN O
+of ADP O
+SNPs NOUN B-AC
+. PUNCT O
+CI NOUN O
+is AUX O
+used VERB O
+to PART O
+assess VERB O
+the DET O
+reliability NOUN O
+of ADP O
+the DET O
+estimate NOUN O
+of ADP O
+Dˊ. NOUN B-AC
+Strong ADJ O
+LD NOUN B-AC
+is AUX O
+defined VERB O
+as SCONJ O
+the DET O
+upper ADJ O
+limit NOUN O
+of ADP O
+the DET O
+90 NUM O
+% NOUN O
+CI NOUN O
+is AUX O
+( PUNCT O
+0.98 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+lower ADJ O
+limit NOUN O
+is AUX O
+( PUNCT O
+0.7 NUM O
+) PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+MRSA PROPN B-AC
+: PUNCT O
+methicillin NOUN O
+- PUNCT O
+resistant ADJ O
+Staphylococcus PROPN O
+aureus NOUN O
+, PUNCT O
+CI NOUN B-AC
+: PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+. PUNCT O
+
+Then ADV O
+, PUNCT O
+construct NOUN O
+validity NOUN O
+of ADP O
+the DET O
+single ADJ O
+factor NOUN O
+CBI PROPN B-AC
+was AUX O
+assessed VERB O
+using VERB O
+Confirmatory PROPN B-LF
+Factor PROPN I-LF
+Analysis PROPN I-LF
+( PUNCT O
+CFA PROPN B-AC
+) PUNCT O
+. PUNCT O
+Since SCONJ O
+one NUM O
+factor NOUN O
+CBI PROPN B-AC
+was AUX O
+not PART O
+confirmed VERB O
+, PUNCT O
+construct NOUN O
+validity NOUN O
+was AUX O
+examined VERB O
+using VERB O
+Exploratory PROPN B-LF
+Factor PROPN I-LF
+Analysis PROPN I-LF
+( PUNCT O
+EFA PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+final ADJ O
+number NOUN O
+of ADP O
+factors NOUN O
+was AUX O
+confirmed VERB O
+using VERB O
+CFA PROPN B-AC
+. PUNCT O
+
+An DET O
+abnormal ADJ O
+presence NOUN O
+of ADP O
+these DET O
+proteins NOUN O
+would AUX O
+be AUX O
+a DET O
+better ADJ O
+marker NOUN O
+of ADP O
+kidney NOUN O
+lesions NOUN O
+and CCONJ O
+would AUX O
+precede VERB O
+glomerular ADJ B-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+GFR PROPN B-AC
+) PUNCT O
+decrease NOUN O
+and CCONJ O
+serum NOUN B-LF
+creatinine NOUN I-LF
+( PUNCT O
+sCr NOUN B-AC
+) PUNCT O
+increase NOUN O
+. PUNCT O
+
+At ADP O
+2 NUM O
+days NOUN B-LF
+after ADP I-LF
+pollination NOUN I-LF
+( PUNCT O
+DAP PROPN B-AC
+) PUNCT O
+, PUNCT O
+when SCONJ O
+the DET O
+majority NOUN O
+of ADP O
+wild ADJ O
+- ADJ O
+type NOUN O
+embryos NOUN O
+had AUX O
+undergone VERB O
+two NUM O
+or CCONJ O
+three NUM O
+cell NOUN O
+divisions NOUN O
+( PUNCT O
+two- NUM O
+to ADP O
+four NUM O
+- ADJ O
+cell NOUN O
+embryo NOUN O
+proper ADJ O
+) PUNCT O
+, PUNCT O
+the DET O
+majority NOUN O
+of ADP O
+mutant ADJ O
+embryos NOUN O
+had AUX O
+divided VERB O
+only ADV O
+once ADV O
+or CCONJ O
+not PART O
+at ADP O
+all DET O
+( PUNCT O
+Figure PROPN O
+S7A NOUN O
+and CCONJ O
+S7C NOUN O
+– SYM O
+E NOUN O
+) PUNCT O
+. PUNCT O
+Endosperm NOUN O
+development NOUN O
+was AUX O
+delayed VERB O
+in ADP O
+comparison NOUN O
+to ADP O
+the DET O
+wild ADJ O
+type NOUN O
+( PUNCT O
+Figure PROPN O
+S7C NOUN O
+– SYM O
+E NOUN O
+) PUNCT O
+. PUNCT O
+At ADP O
+3 NUM O
+DAP PROPN B-AC
+, PUNCT O
+a DET O
+proportion NOUN O
+of ADP O
+unfertilized ADJ O
+ovules NOUN O
+and CCONJ O
+seeds NOUN O
+( PUNCT O
+likely ADV O
+arrested VERB O
+around ADP O
+the DET O
+zygote NOUN O
+stage NOUN O
+) PUNCT O
+had AUX O
+started VERB O
+degeneration NOUN O
+and CCONJ O
+collapsed VERB O
+( PUNCT O
+Figure PROPN O
+6E NUM O
+, PUNCT O
+Figure PROPN O
+S7B NOUN O
+and CCONJ O
+S7F NOUN O
+) PUNCT O
+. PUNCT O
+Only ADV O
+about ADV O
+10 NUM O
+% NOUN O
+of ADP O
+embryos NOUN O
+with ADP O
+a DET O
+developmental ADJ O
+delay NOUN O
+developed VERB O
+into ADP O
+a DET O
+two- NUM O
+or CCONJ O
+four NUM O
+- ADJ O
+cell NOUN O
+embryo NOUN O
+, PUNCT O
+while SCONJ O
+the DET O
+majority NOUN O
+of ADP O
+wild ADJ O
+- ADJ O
+type NOUN O
+embryos NOUN O
+had AUX O
+reached VERB O
+the DET O
+octant ADJ O
+or CCONJ O
+early ADJ O
+globular ADJ O
+stage NOUN O
+( PUNCT O
+Figure PROPN O
+S7B NOUN O
+) PUNCT O
+. PUNCT O
+At ADP O
+4 NUM O
+DAP PROPN B-AC
+, PUNCT O
+the DET O
+majority NOUN O
+of ADP O
+arrested VERB O
+seeds NOUN O
+had AUX O
+collapsed VERB O
+and CCONJ O
+only ADV O
+infrequently ADV O
+, PUNCT O
+in ADP O
+about ADV O
+1 NUM O
+% NOUN O
+of ADP O
+all DET O
+ovules NOUN O
+and CCONJ O
+seeds NOUN O
+( PUNCT O
+N NOUN O
+= SYM O
+149 NUM O
+) PUNCT O
+, PUNCT O
+arrest NOUN O
+at ADP O
+the DET O
+mid ADJ O
+- ADJ O
+globular ADJ O
+stage NOUN O
+was AUX O
+observed VERB O
+( PUNCT O
+Figure PROPN O
+6 NUM O
+G NOUN O
+) PUNCT O
+. PUNCT O
+
+One NUM O
+key ADJ O
+example NOUN O
+of ADP O
+effectiveness NOUN O
+was AUX O
+the DET O
+European ADJ O
+DE PROPN B-AC
+- PUNCT B-AC
+PLAN PROPN B-AC
+( PUNCT O
+Diabetes NOUN B-LF
+in ADP I-LF
+Europe PROPN I-LF
+– PUNCT I-LF
+Prevention PROPN I-LF
+using VERB I-LF
+lifestyle NOUN I-LF
+, PUNCT I-LF
+physical ADJ I-LF
+activity NOUN I-LF
+and CCONJ I-LF
+nutritional ADJ I-LF
+intervention NOUN I-LF
+) PUNCT O
+project NOUN O
+applied VERB O
+in ADP O
+Catalonia PROPN O
+( PUNCT O
+DE PROPN B-AC
+- PUNCT B-AC
+PLAN PROPN B-AC
+- PUNCT O
+CAT PROPN O
+) PUNCT O
+. PUNCT O
+Diabetes NOUN O
+incidence NOUN O
+was AUX O
+reduced VERB O
+by ADP O
+36.5 NUM O
+% NOUN O
+at ADP O
+the DET O
+4 NUM O
+- PUNCT O
+year NOUN O
+follow NOUN O
+- PUNCT O
+up NOUN O
+in ADP O
+333 NUM O
+participants NOUN O
+carrying VERB O
+out ADP O
+the DET O
+intensive ADJ O
+lifestyle NOUN O
+intervention NOUN O
+compared VERB O
+to ADP O
+the DET O
+standard ADJ O
+care NOUN O
+regime NOUN O
+[ PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+TE PROPN B-AC
+, PUNCT O
+translational ADJ B-LF
+efficiency NOUN I-LF
+; PUNCT O
+uORF PROPN B-AC
+, PUNCT O
+upstream ADJ B-LF
+open ADJ I-LF
+reading NOUN I-LF
+frame NOUN I-LF
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+we PRON O
+performed VERB O
+association NOUN O
+analysis NOUN O
+of ADP O
+both DET O
+imputed ADJ O
+data NOUN O
+sets NOUN O
+for ADP O
+the DET O
+Low ADJ B-LF
+- PUNCT I-LF
+Density NOUN I-LF
+lipoprotein NOUN I-LF
+concentration NOUN I-LF
+( PUNCT O
+LDL NOUN B-AC
+- PUNCT B-AC
+C NOUN B-AC
+) PUNCT O
+phenotype NOUN O
+relevant ADJ O
+for ADP O
+premature ADJ O
+cardio ADJ O
+atherosclerotic ADJ O
+disease NOUN O
+. PUNCT O
+
+Since SCONJ O
+then ADV O
+, PUNCT O
+numerous ADJ O
+other ADJ O
+VOCs NOUN B-AC
+have AUX O
+been AUX O
+identified VERB O
+through ADP O
+genomic ADJ O
+sequencing NOUN O
+of ADP O
+positive ADJ O
+cases NOUN O
+worldwide ADV O
+; PUNCT O
+most ADV O
+notably ADV O
+with ADP O
+in ADP O
+the DET O
+UK PROPN O
+with ADP O
+COVID-19 PROPN B-LF
+Genomics PROPN I-LF
+UK PROPN I-LF
+Consortium PROPN I-LF
+( PUNCT O
+COG PROPN B-AC
+- PUNCT B-AC
+UK PROPN B-AC
+) PUNCT O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+Regulation NOUN O
+of ADP O
+miRNAs NOUN B-AC
+were AUX O
+interlinked VERB O
+with ADP O
+upstream ADJ O
+regulators NOUN O
+such ADJ O
+as ADP O
+Argonaut PROPN O
+2 NUM O
+( PUNCT O
+AGO2 PROPN O
+) PUNCT O
+, PUNCT O
+Double PROPN B-LF
+- PUNCT I-LF
+Stranded PROPN I-LF
+RNA PROPN I-LF
+- PUNCT I-LF
+Specific PROPN I-LF
+Endoribonuclease NOUN I-LF
+( PUNCT O
+DICER1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+Sjogren PROPN B-LF
+syndrome PROPN I-LF
+antigen NOUN I-LF
+B PROPN I-LF
+( PUNCT O
+SSB PROPN B-AC
+) PUNCT O
+, PUNCT O
+neurofibromatosis NOUN B-LF
+2 NUM I-LF
+( PUNCT O
+NF2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+peroxisome NOUN B-LF
+proliferator NOUN I-LF
+activated VERB I-LF
+receptor NOUN I-LF
+alpha NOUN I-LF
+( PUNCT O
+PPARA PROPN B-AC
+) PUNCT O
+, PUNCT O
+activated VERB O
+during ADP O
+stage NOUN O
+- PUNCT O
+specific ADJ O
+disease NOUN O
+progression NOUN O
+. PUNCT O
+
+Further ADV O
+, PUNCT O
+some DET O
+meta NOUN O
+- PUNCT O
+heuristic NOUN O
+based VERB O
+techniques NOUN O
+, PUNCT O
+for ADP O
+example NOUN O
+, PUNCT O
+Whale PROPN B-LF
+Optimization PROPN I-LF
+Algorithm PROPN I-LF
+( PUNCT O
+WOA PROPN B-AC
+) PUNCT O
+[ X O
+25 NUM O
+] PUNCT O
+, PUNCT O
+Moth PROPN B-LF
+- PUNCT I-LF
+Flame PROPN I-LF
+Optimization PROPN I-LF
+Algorithm PROPN I-LF
+( PUNCT O
+MFO PROPN B-AC
+) PUNCT O
+[ X O
+26 NUM O
+] PUNCT O
+, PUNCT O
+Glowworm PROPN O
+Swarm PROPN O
+Optimization PROPN O
+Algorithm PROPN O
+( PUNCT O
+GSO PROPN B-AC
+) PUNCT O
+[ X O
+27 NUM O
+] PUNCT O
+, PUNCT O
+Jaya PROPN B-LF
+Algorithm PROPN I-LF
+( PUNCT O
+JA PROPN B-AC
+) PUNCT O
+[ X O
+28 NUM O
+] PUNCT O
+, PUNCT O
+Artificial PROPN B-LF
+Bee PROPN I-LF
+Colony PROPN I-LF
+Algorithm PROPN I-LF
+( PUNCT O
+ABC PROPN B-AC
+) PUNCT O
+[ X O
+29 NUM O
+] PUNCT O
+were AUX O
+employed VERB O
+to PART O
+solve VERB O
+OPF PROPN B-AC
+problem NOUN O
+effectively ADV O
+and CCONJ O
+accurately ADV O
+. PUNCT O
+
+Plasma NOUN O
+free ADJ B-LF
+fatty ADJ I-LF
+acid NOUN I-LF
+( PUNCT O
+FFA PROPN B-AC
+) PUNCT O
+levels NOUN O
+( PUNCT O
+in ADP O
+μmol NOUN O
+/ SYM O
+L NOUN O
+) PUNCT O
+were AUX O
+determined VERB O
+enzymatically ADV O
+( PUNCT O
+NEFAC PROPN O
+kit NOUN O
+, PUNCT O
+WAKO PROPN O
+Chemicals PROPN O
+, PUNCT O
+Neuss PROPN O
+, PUNCT O
+Germany PROPN O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+report VERB O
+here ADV O
+the DET O
+discovery NOUN O
+of ADP O
+a DET O
+novel ADJ O
+lantibiotic NOUN O
+for ADP O
+the DET O
+treatment NOUN O
+of ADP O
+C. NOUN B-LF
+difficile ADJ I-LF
+infection NOUN I-LF
+( PUNCT O
+CDI PROPN B-AC
+) PUNCT O
+. PUNCT O
+The DET O
+leads NOUN O
+were AUX O
+selected VERB O
+from ADP O
+a DET O
+library NOUN O
+of ADP O
+over ADP O
+300 NUM O
+multiple ADJ O
+substitution NOUN O
+variants NOUN O
+of ADP O
+the DET O
+lantibiotic NOUN O
+Mutacin PROPN B-LF
+1140 NUM I-LF
+( PUNCT O
+MU1140 PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+We PRON O
+therefore ADV O
+sought VERB O
+to PART O
+investigate VERB O
+this DET O
+question NOUN O
+in ADP O
+a DET O
+large ADJ O
+case NOUN O
+- PUNCT O
+cohort NOUN O
+study NOUN O
+nested VERB O
+within ADP O
+the DET O
+European PROPN B-LF
+Prospective PROPN I-LF
+Investigation PROPN I-LF
+into ADP I-LF
+Cancer PROPN I-LF
+and CCONJ I-LF
+Nutrition PROPN I-LF
+( PUNCT O
+EPIC PROPN B-AC
+) PUNCT O
+study NOUN O
+. PUNCT O
+
+BMAL1 PROPN O
+, PUNCT O
+brain NOUN O
+and CCONJ O
+muscle NOUN O
+ARNT NOUN O
+- PUNCT O
+like ADJ O
+protein NOUN O
+1 NUM O
+; PUNCT O
+CLOCK PROPN B-AC
+, PUNCT O
+circadian ADJ B-LF
+locomotor ADJ I-LF
+output NOUN I-LF
+cycles NOUN I-LF
+protein NOUN I-LF
+kaput NOUN I-LF
+; PUNCT O
+JMJD5 PROPN B-AC
+, PUNCT O
+JmjC PROPN B-LF
+domain NOUN I-LF
+– PUNCT I-LF
+containing VERB I-LF
+protein NOUN I-LF
+5 NUM I-LF
+. PUNCT O
+
+Queensland PROPN O
+includes VERB O
+443 NUM O
+postal ADJ O
+areas NOUN O
+( PUNCT O
+Australian PROPN O
+Bureau PROPN O
+of ADP O
+Statistics PROPN O
+, PUNCT O
+postal ADJ O
+areas NOUN O
+Australian PROPN B-LF
+Statistical PROPN I-LF
+Geography PROPN I-LF
+Standard PROPN I-LF
+[ PUNCT O
+ASGS PROPN B-AC
+] X O
+Edition PROPN O
+2016 NUM O
+) PUNCT O
+. PUNCT O
+
+Pro NOUN B-LF
+- NOUN I-LF
+myeloperoxidase NOUN I-LF
+( PUNCT O
+pro NOUN B-AC
+- NOUN B-AC
+MPO PROPN B-AC
+) PUNCT O
+, PUNCT O
+an DET O
+enzymatically ADV O
+active ADJ O
+precursor NOUN O
+of ADP O
+myeloperoxidase NOUN B-LF
+( PUNCT O
+MPO PROPN B-AC
+) PUNCT O
+, PUNCT O
+is AUX O
+known VERB O
+to PART O
+be AUX O
+secreted VERB O
+from ADP O
+cultured ADJ O
+bone NOUN O
+marrow NOUN O
+and CCONJ O
+promyelocytic ADJ O
+leukemia NOUN O
+cells NOUN O
+, PUNCT O
+but CCONJ O
+evidence NOUN O
+for ADP O
+the DET O
+presence NOUN O
+of ADP O
+pro NOUN B-AC
+- NOUN B-AC
+MPO PROPN B-AC
+in ADP O
+circulation NOUN O
+is AUX O
+lacking VERB O
+. PUNCT O
+
+HT PROPN B-AC
+: PUNCT O
+hypertensive ADJ B-LF
+. PUNCT O
+
+By ADP O
+reviewing VERB O
+the DET O
+slides NOUN O
+through ADP O
+H&E PROPN B-AC
+and CCONJ O
+CRP NOUN B-AC
+immunostaining NOUN O
+, PUNCT O
+we PRON O
+categorized VERB O
+the DET O
+patients NOUN O
+into ADP O
+( PUNCT O
+1 NUM O
+) PUNCT O
+AAA NOUN B-AC
+- PUNCT B-AC
+high ADJ B-AC
+mCRP NOUN B-AC
+( PUNCT O
+abdominal ADJ B-LF
+aortic ADJ I-LF
+aneurysm NOUN I-LF
+with ADP O
+high ADJ O
+[ PUNCT O
+moderate ADJ O
+- PUNCT O
+to ADP O
+- PUNCT O
+strong ADJ O
+( PUNCT O
+intensity NOUN O
+: PUNCT O
+2 X O
++ PUNCT O
+, PUNCT O
+3 X O
++ PUNCT O
+) PUNCT O
+] PUNCT O
+and CCONJ O
+diffuse ADJ O
+CRP NOUN B-AC
+immunopositivity NOUN O
+) PUNCT O
+, PUNCT O
+( PUNCT O
+2 X O
+) PUNCT O
+AAA NOUN B-AC
+- PUNCT B-AC
+low ADJ B-AC
+mCRP NOUN B-AC
+( PUNCT O
+abdominal ADJ B-LF
+aortic ADJ I-LF
+aneurysm NOUN I-LF
+with ADP O
+low ADJ O
+[ PUNCT O
+negative ADJ O
+- PUNCT O
+to ADP O
+- PUNCT O
+weak ADJ O
+( PUNCT O
+intensity NOUN O
+: PUNCT O
+0 NUM O
+, PUNCT O
+1 NUM O
++ PUNCT O
+) PUNCT O
+] PUNCT O
+, PUNCT O
+focal ADJ O
+, PUNCT O
+and CCONJ O
+junctional ADJ O
+CRP NOUN B-AC
+immunopositivity NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+( PUNCT O
+3 X O
+) PUNCT O
+AAD PROPN B-AC
+groups NOUN O
+. PUNCT O
+
+Tumors NOUN O
+, PUNCT O
+in ADP O
+turn NOUN O
+, PUNCT O
+inhibit VERB O
+this DET O
+anti ADJ O
+- PUNCT O
+tumor NOUN O
+activity NOUN O
+by ADP O
+producing VERB O
+immunosuppressive ADJ O
+cytokines NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+IL-10 NOUN B-AC
+and CCONJ O
+TNF NOUN B-AC
+- PUNCT O
+β NOUN O
+, PUNCT O
+and CCONJ O
+inducing VERB O
+immunosuppressive ADJ O
+cells NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+Tregs NOUN B-AC
+, PUNCT O
+tumor NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+macrophages NOUN I-LF
+( PUNCT O
+TAMs PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+myeloid NOUN B-LF
+- PUNCT I-LF
+derived VERB I-LF
+suppressor NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+MDSC PROPN B-AC
+) PUNCT O
+[ X O
+21–24 NUM O
+] PUNCT O
+. PUNCT O
+
+Yet CCONJ O
+, PUNCT O
+the DET O
+diversity NOUN O
+of ADP O
+α NOUN O
+- ADJ O
+arrestin ADJ O
+targets NOUN O
+studied VERB O
+is AUX O
+restricted VERB O
+to ADP O
+a DET O
+small ADJ O
+subset NOUN O
+of ADP O
+plasma NOUN B-LF
+membrane NOUN I-LF
+( PUNCT O
+PM PROPN B-AC
+) PUNCT O
+proteins NOUN O
+. PUNCT O
+
+The DET O
+majority NOUN O
+of ADP O
+the DET O
+HYPEST PROPN O
+participants NOUN O
+( PUNCT O
+n NOUN O
+= SYM O
+1,482 NUM O
+) PUNCT O
+possess VERB O
+a DET O
+documented VERB O
+history NOUN O
+of ADP O
+multiple ADJ O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+( PUNCT O
+SBP PROPN B-AC
+) PUNCT O
+and CCONJ O
+diastolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+( PUNCT O
+DBP PROPN B-AC
+) PUNCT O
+readings NOUN O
+. PUNCT O
+
+EGF PROPN O
+, PUNCT O
+epidermal ADJ O
+growth NOUN O
+factor NOUN O
+; PUNCT O
+EGFR PROPN B-AC
+, PUNCT O
+epidermal ADJ B-LF
+growth NOUN I-LF
+factor NOUN I-LF
+receptor NOUN I-LF
+; PUNCT O
+FCHSD2 PROPN B-AC
+, PUNCT O
+FCH PROPN B-LF
+/ SYM I-LF
+F PROPN I-LF
+- PUNCT I-LF
+BAR PROPN I-LF
+and CCONJ I-LF
+Double PROPN I-LF
+SH3 PROPN I-LF
+Domain PROPN I-LF
+- PUNCT I-LF
+Containing PROPN I-LF
+Protein PROPN I-LF
+; PUNCT O
+KD PROPN B-AC
+, PUNCT O
+knockdown NOUN B-LF
+; PUNCT O
+LAMP1 PROPN B-AC
+, PUNCT O
+lysosome NOUN B-LF
+- PUNCT I-LF
+associated VERB I-LF
+membrane NOUN I-LF
+glycoprotein NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+siCtrl PROPN O
+, PUNCT O
+control NOUN O
+siRNA NOUN B-AC
+; PUNCT O
+siRNA NOUN B-AC
+, PUNCT O
+small ADJ B-LF
+interfering VERB I-LF
+RNA NOUN I-LF
+. PUNCT O
+
+There PRON O
+was VERB O
+no DET O
+evidence NOUN O
+of ADP O
+heterogeneity NOUN O
+of ADP O
+individual ADJ O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphism NOUN I-LF
+( PUNCT O
+SNP PROPN B-AC
+) PUNCT O
+allele NOUN O
+frequencies NOUN O
+between ADP O
+case NOUN O
+groups NOUN O
+or CCONJ O
+control NOUN O
+groups NOUN O
+( PUNCT O
+all PRON O
+p NOUN O
+> ADP O
+0.01 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+found VERB O
+that SCONJ O
+damaged VERB B-LF
+DNA NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+DDB1 PROPN B-AC
+) PUNCT O
+, PUNCT O
+viral ADJ B-LF
+protein NOUN I-LF
+R NOUN I-LF
+binding VERB I-LF
+protein NOUN I-LF
+( PUNCT O
+VPRBP PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+cullin NOUN B-LF
+4A NOUN I-LF
+( PUNCT O
+CUL4A)—components PROPN B-AC
+of ADP O
+a DET O
+CUL4A PROPN B-AC
+E3 PROPN O
+ubiquitin NOUN O
+ligase NOUN O
+complex NOUN O
+, PUNCT O
+DDB1 PROPN B-AC
+- PUNCT O
+CUL4AVPRBP PROPN O
+— PUNCT O
+were AUX O
+able ADJ O
+to PART O
+associate VERB O
+with ADP O
+Vpr PROPN B-AC
+. PUNCT O
+
+CKIP-1 PROPN O
+loss NOUN O
+of ADP O
+function NOUN O
+and CCONJ O
+Smurf1 PROPN B-AC
+overexpression NOUN B-LF
+( PUNCT O
+OE NOUN B-AC
+) PUNCT O
+each PRON O
+result VERB O
+in ADP O
+reduced VERB O
+BMP NOUN B-AC
+signaling NOUN O
+output NOUN O
+and CCONJ O
+reduced VERB O
+paired VERB B-LF
+box NOUN I-LF
+7 NUM I-LF
+( PUNCT O
+Pax7 PROPN B-AC
+) PUNCT O
+expression NOUN O
+in ADP O
+the DET O
+neural ADJ O
+plate NOUN O
+border NOUN O
+domain NOUN O
+. PUNCT O
+
+We PRON O
+report VERB O
+2 NUM O
+types NOUN O
+of ADP O
+analysis NOUN O
+, PUNCT O
+one NUM O
+on ADP O
+the DET O
+intention NOUN B-LF
+to ADP I-LF
+treat VERB I-LF
+( PUNCT O
+ITT PROPN B-AC
+) PUNCT O
+population NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+all DET O
+participants NOUN O
+randomised VERB O
+at ADP O
+baseline NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+other ADJ O
+on ADP O
+the DET O
+PP PROPN B-AC
+population NOUN O
+, PUNCT O
+i.e. X O
+, PUNCT O
+including VERB O
+only ADV O
+those DET O
+FG PROPN B-AC
+participants NOUN O
+who PRON O
+adhered VERB O
+to ADP O
+the DET O
+a DET O
+priori X O
+PP PROPN B-AC
+attendance NOUN O
+rate NOUN O
+of ADP O
+a DET O
+minimum NOUN O
+of ADP O
+50 NUM O
+% NOUN O
+of ADP O
+training NOUN O
+sessions NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+This DET O
+prospective ADJ O
+, PUNCT O
+pragmatic ADJ O
+randomized ADJ O
+controlled ADJ O
+trial NOUN O
+compares VERB O
+an DET O
+intervention NOUN B-LF
+group NOUN I-LF
+( PUNCT O
+IG PROPN B-AC
+) PUNCT O
+of ADP O
+participants NOUN O
+in ADP O
+TBHC PROPN B-AC
+to ADP O
+a DET O
+control NOUN B-LF
+group NOUN I-LF
+( PUNCT O
+CG NOUN B-AC
+) PUNCT O
+without ADP O
+TBHC PROPN B-AC
+. PUNCT O
+Endpoints NOUN O
+were AUX O
+assessed VERB O
+two NUM O
+years NOUN O
+after ADP O
+enrolment NOUN O
+. PUNCT O
+
+MNE PROPN O
+, PUNCT O
+mean ADJ O
+normalised VERB O
+expression NOUN O
+; PUNCT O
+ABW PROPN B-AC
+, PUNCT O
+Average ADJ B-LF
+birth NOUN I-LF
+weight NOUN I-LF
+; PUNCT O
+LBW PROPN B-AC
+, PUNCT O
+Low ADJ B-LF
+birth NOUN I-LF
+weight NOUN I-LF
+; PUNCT O
+* PUNCT O
+P<0.05 NUM O
+from ADP O
+ABW PROPN B-AC
+. PUNCT O
+
+Endothelial ADJ B-LF
+cells NOUN I-LF
+( PUNCT O
+ECs NOUN B-AC
+) PUNCT O
+[ X O
+26 NUM O
+] X O
+, PUNCT O
+leukocytes NOUN O
+[ X O
+27 NUM O
+] X O
+and CCONJ O
+HSCs NOUN B-AC
+[ X O
+28 NUM O
+] X O
+are AUX O
+reported VERB O
+to ADP O
+contribute VERB O
+to ADP O
+Hh NOUN B-AC
+ligand NOUN O
+production NOUN O
+in ADP O
+cirrhotic ADJ O
+liver NOUN O
+disease NOUN O
+. PUNCT O
+
+Randomisation NOUN O
+was AUX O
+at ADP O
+a DET O
+1:2:2 NUM O
+allocation NOUN O
+ratio NOUN O
+to ADP O
+( PUNCT O
+i X O
+) PUNCT O
+image NOUN O
+- PUNCT O
+read VERB O
+LBC PROPN B-AC
+screening NOUN O
+with ADP O
+HPV PROPN B-AC
+triage NOUN O
+testing NOUN O
+of ADP O
+low ADJ O
+- PUNCT O
+grade NOUN O
+cytology NOUN O
+( PUNCT O
+‘ PUNCT O
+LBC PROPN B-AC
+screening NOUN O
+’ PUNCT O
+) PUNCT O
+; PUNCT O
+( PUNCT O
+ii X O
+) PUNCT O
+HPV PROPN B-AC
+screening NOUN O
+with ADP O
+partial ADJ O
+genotyping NOUN O
+and CCONJ O
+direct ADJ O
+referral NOUN O
+of ADP O
+women NOUN O
+with ADP O
+detected VERB O
+HPV16/18 NUM O
+to ADP O
+colposcopy NOUN O
+and CCONJ O
+with ADP O
+LBC PROPN B-AC
+triage NOUN O
+for ADP O
+other ADJ O
+‘ PUNCT O
+high ADJ O
+risk NOUN O
+’ PUNCT O
+( PUNCT O
+OHR PROPN O
+) PUNCT O
+oncogenic ADJ O
+types NOUN O
+( PUNCT O
+‘ PUNCT O
+HPV+LBC PROPN B-AC
+triage NOUN O
+’ PUNCT O
+; PUNCT O
+equivalent ADJ O
+to ADP O
+the DET O
+new ADJ O
+screening NOUN O
+recommendations NOUN O
+in ADP O
+Australia PROPN O
+) PUNCT O
+; PUNCT O
+or CCONJ O
+( PUNCT O
+iii X O
+) PUNCT O
+HPV PROPN B-AC
+screening NOUN O
+with ADP O
+partial ADJ O
+genotyping NOUN O
+and CCONJ O
+direct ADJ O
+referral NOUN O
+of ADP O
+women NOUN O
+with ADP O
+detected VERB O
+HPV16/18 NUM O
+to ADP O
+colposcopy NOUN O
+and CCONJ O
+with ADP O
+dual ADJ B-LF
+- PUNCT I-LF
+stained VERB I-LF
+cytology NOUN O
+triage NOUN O
+testing NOUN O
+for ADP O
+other ADJ O
+oncogenic ADJ O
+types NOUN O
+( PUNCT O
+‘ PUNCT O
+HPV+DS PROPN B-AC
+triage NOUN O
+’ PUNCT O
+) PUNCT O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+CQI PROPN B-AC
+, PUNCT O
+continuous ADJ B-LF
+quality NOUN I-LF
+improvement NOUN I-LF
+; PUNCT O
+RD NOUN O
+, PUNCT O
+risk NOUN O
+difference NOUN O
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+relative ADJ B-LF
+risk NOUN I-LF
+; PUNCT O
+VL PROPN B-AC
+, PUNCT O
+HIV PROPN B-LF
+viral ADJ I-LF
+load NOUN I-LF
+
+VPA NOUN B-AC
+= PUNCT O
+Vigorous ADJ B-LF
+physical ADJ I-LF
+activity NOUN I-LF
+. PUNCT O
+
+For ADP O
+this PRON O
+, PUNCT O
+the DET O
+ectodomain NOUN O
+of ADP O
+AMA1 PROPN B-AC
+forms VERB O
+adhesive ADJ O
+interactions NOUN O
+with ADP O
+rhoptry PROPN B-LF
+neck NOUN I-LF
+protein NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+RON2 PROPN B-AC
+) PUNCT O
+, PUNCT O
+another DET O
+parasite NOUN O
+protein NOUN O
+, PUNCT O
+which PRON O
+is AUX O
+secreted VERB O
+from ADP O
+a DET O
+third ADJ O
+set NOUN O
+of ADP O
+secretory ADJ O
+organelles NOUN O
+called VERB O
+rhoptries NOUN O
+into ADP O
+the DET O
+erythrocyte NOUN O
+membrane NOUN O
+[ X O
+18–21 NUM O
+] PUNCT O
+. PUNCT O
+
+Indeed ADV O
+, PUNCT O
+all DET O
+patients NOUN O
+receiving VERB O
+animal NOUN O
+polyclonal ADJ O
+IgGs NOUN O
+without ADP O
+other ADJ O
+immunosuppression NOUN B-LF
+( PUNCT O
+IS NOUN B-AC
+) PUNCT O
+develop VERB O
+severe ADJ O
+symptoms NOUN O
+of ADP O
+immune ADJ O
+- PUNCT O
+complex ADJ O
+disease NOUN O
+( PUNCT O
+serum NOUN O
+sickness NOUN O
+disease NOUN O
+) PUNCT O
+[ PUNCT O
+6 NUM O
+] PUNCT O
+. PUNCT O
+
+GFP PROPN B-AC
+- PUNCT O
+α NOUN B-AC
+- PUNCT B-AC
+Ada PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+fused VERB O
+with ADP O
+α NOUN B-LF
+- PUNCT I-LF
+Adaptin PROPN I-LF
+; PUNCT O
+imac NOUN B-AC
+, PUNCT O
+immaculate ADJ B-LF
+connections NOUN I-LF
+; PUNCT O
+RNAi NOUN B-AC
+, PUNCT O
+RNA NOUN B-LF
+interference NOUN I-LF
+; PUNCT O
+Venus PROPN O
+- PUNCT O
+Prd1 PROPN O
+, PUNCT O
+Venus PROPN O
+- PUNCT O
+Pruning NOUN O
+defect NOUN O
+1 NUM O
+. PUNCT O
+
+We PRON O
+used VERB O
+mathematical ADJ O
+modeling NOUN O
+to ADP O
+predict VERB O
+the DET O
+impact NOUN O
+of ADP O
+the DET O
+scale NOUN O
+- PUNCT O
+up NOUN O
+of ADP O
+DTG PROPN B-AC
+- PUNCT O
+based VERB O
+ART PROPN B-AC
+on ADP O
+NNRTI PROPN B-AC
+pretreatment NOUN B-LF
+drug NOUN I-LF
+resistance NOUN I-LF
+( PUNCT O
+PDR NOUN B-AC
+) PUNCT O
+in ADP O
+South PROPN O
+Africa PROPN O
+, PUNCT O
+2020 NUM O
+to ADP O
+2040 NUM O
+. PUNCT O
+
+chaperone NOUN B-LF
+protein NOUN I-LF
+DnaK PROPN I-LF
+
+Bioassay NOUN O
+of ADP O
+the DET O
+field NOUN O
+population NOUN O
+of ADP O
+N. PROPN O
+lugens PROPN O
+collected VERB O
+from ADP O
+Guangxi PROPN O
+, PUNCT O
+China PROPN O
+( PUNCT O
+called VERB O
+GX PROPN O
+- PUNCT O
+P PROPN O
+) PUNCT O
+in ADP O
+2011 NUM O
+showed VERB O
+that SCONJ O
+it PRON O
+had VERB O
+a DET O
+50 NUM B-LF
+% NOUN I-LF
+lethal ADJ I-LF
+concentration NOUN I-LF
+( PUNCT O
+LC50 NUM B-AC
+) PUNCT O
+of ADP O
+30.98 NUM O
+mg NOUN O
+/ SYM O
+l NOUN O
+( PUNCT O
+S1 PROPN O
+Table PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+antioxidant ADJ O
+activities NOUN O
+of ADP O
+the DET O
+extracts NOUN O
+were AUX O
+evaluated VERB O
+using VERB O
+assays NOUN O
+to PART O
+assess VERB O
+DPPH NOUN B-AC
+( PUNCT O
+1,1 NUM B-LF
+- PUNCT I-LF
+diphenyl-2 NOUN I-LF
+- PUNCT I-LF
+picryl NOUN I-LF
+- PUNCT I-LF
+hydrazyl NOUN I-LF
+) PUNCT O
+and CCONJ O
+hydroxyl NOUN O
+radical NOUN O
+scavenging NOUN O
+activities NOUN O
+, PUNCT O
+metal NOUN O
+- PUNCT O
+chelating VERB O
+activity NOUN O
+and CCONJ O
+reducing VERB O
+power NOUN O
+of ADP O
+the DET O
+extracts NOUN O
+. PUNCT O
+
+RBPs NOUN B-AC
+are AUX O
+members NOUN O
+of ADP O
+the DET O
+intracellular ADJ O
+lipid NOUN O
+binding VERB O
+proteins NOUN O
+that PRON O
+display VERB O
+a DET O
+high ADJ O
+binding VERB O
+affinity NOUN O
+to ADP O
+all PRON B-LF
+- NOUN I-LF
+trans NOUN I-LF
+- NOUN I-LF
+retinol NOUN I-LF
+( PUNCT O
+ROL PROPN B-AC
+) PUNCT O
+[ PUNCT O
+12–14 NUM O
+] PUNCT O
+. PUNCT O
+
+Phosphoglycerate NOUN B-LF
+kinase NOUN I-LF
+1 NUM O
+( PUNCT O
+PGK1 PROPN B-AC
+) PUNCT O
+catalyzes VERB O
+the DET O
+reversible ADJ O
+transfer NOUN O
+of ADP O
+a DET O
+phosphoryl NOUN O
+group NOUN O
+from ADP O
+1 NUM B-LF
+, PUNCT I-LF
+3 NUM I-LF
+- PUNCT I-LF
+bisphosphoglycerate NOUN I-LF
+( PUNCT O
+1 NUM B-AC
+, PUNCT B-AC
+3 NUM B-AC
+- PUNCT B-AC
+BPG NOUN B-AC
+) PUNCT O
+to ADP O
+ADP PROPN O
+, PUNCT O
+producing VERB O
+3 NUM B-LF
+- PUNCT I-LF
+phosphoglycerate NOUN I-LF
+( PUNCT O
+3 NUM B-AC
+- PUNCT B-AC
+PG NOUN B-AC
+) PUNCT O
+and CCONJ O
+ATP PROPN O
+. PUNCT O
+PGK1 PROPN B-AC
+plays VERB O
+a DET O
+key ADJ O
+role NOUN O
+in ADP O
+coordinating VERB O
+glycolytic ADJ O
+energy NOUN O
+production NOUN O
+with ADP O
+one NUM O
+- PUNCT O
+carbon NOUN O
+metabolism NOUN O
+, PUNCT O
+serine NOUN O
+biosynthesis NOUN O
+, PUNCT O
+and CCONJ O
+cellular ADJ O
+redox NOUN O
+regulation NOUN O
+. PUNCT O
+
+In ADP O
+the DET O
+mothers NOUN O
+, PUNCT O
+earlier ADJ O
+menarche NOUN O
+was AUX O
+associated VERB O
+with ADP O
+shorter ADJ O
+adult NOUN O
+height NOUN O
+( PUNCT O
+by ADP O
+0.64 NUM O
+cm NOUN O
+/ SYM O
+y NOUN O
+) PUNCT O
+, PUNCT O
+increased VERB O
+weight NOUN O
+( PUNCT O
+0.92 NUM O
+kg NOUN O
+/ SYM O
+y NOUN O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI NOUN B-AC
+, PUNCT O
+0.51 NUM O
+kg NOUN O
+/ SYM O
+m2 NOUN O
+/ SYM O
+y NOUN O
+; PUNCT O
+all PRON O
+p NOUN O
+< ADP O
+0.001 NUM O
+) PUNCT O
+. PUNCT O
+
+It PRON O
+accounts VERB O
+for ADP O
+a DET O
+total NOUN O
+of ADP O
+1,010 NUM O
+open ADJ B-LF
+reading NOUN I-LF
+frames NOUN I-LF
+( PUNCT O
+ORFs NOUN B-AC
+) PUNCT O
+, PUNCT O
+or CCONJ O
+about ADV O
+one PRON O
+- PUNCT O
+third NOUN O
+of ADP O
+the DET O
+functionally ADV O
+assigned VERB O
+ORFs NOUN B-AC
+. PUNCT O
+It PRON O
+is AUX O
+composed VERB O
+of ADP O
+906 NUM O
+metabolic ADJ O
+ORFs NOUN B-AC
+enabling VERB O
+932 NUM O
+biochemical ADJ O
+reactions NOUN O
+( PUNCT O
+including VERB O
+transporters NOUN O
+) PUNCT O
+among ADP O
+625 NUM O
+metabolites NOUN O
+, PUNCT O
+as ADP O
+well ADV O
+as ADP O
+104 NUM O
+TFs NOUN B-AC
+regulating VERB O
+the DET O
+expression NOUN O
+of ADP O
+479 NUM O
+of ADP O
+the DET O
+1,010 NUM O
+ORFs NOUN B-AC
+. PUNCT O
+The DET O
+reconstructed VERB O
+TRN PROPN B-AC
+is AUX O
+implemented VERB O
+with ADP O
+a DET O
+Boolean ADJ O
+logic NOUN O
+formalism NOUN O
+, PUNCT O
+which PRON O
+allows VERB O
+one PRON O
+to PART O
+compute VERB O
+the DET O
+“ PUNCT O
+off ADV O
+/ SYM O
+on ADP O
+” PUNCT O
+expression NOUN O
+status NOUN O
+of ADP O
+genes NOUN O
+based VERB O
+on ADP O
+the DET O
+“ PUNCT O
+inactive ADJ O
+/ SYM O
+active ADJ O
+” PUNCT O
+state NOUN O
+of ADP O
+particular ADJ O
+TFs NOUN B-AC
+and/or CCONJ O
+the DET O
+absence NOUN O
+/ SYM O
+presence NOUN O
+of ADP O
+particular ADJ O
+environmental ADJ O
+constituents NOUN O
+. PUNCT O
+
+Polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+PCR PROPN B-AC
+) PUNCT O
+testing NOUN O
+has AUX O
+identified VERB O
+many ADJ O
+different ADJ O
+viral ADJ O
+causes NOUN O
+of ADP O
+pediatric ADJ O
+SARI PROPN B-AC
+[ X O
+3–6 NUM O
+] PUNCT O
+. PUNCT O
+
+SHORT PROPN B-LF
+- PUNCT I-LF
+ROOT NOUN I-LF
+( PUNCT O
+SHR PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+putative ADJ O
+transcription NOUN O
+factor NOUN O
+of ADP O
+the DET O
+GRAS PROPN O
+family NOUN O
+and CCONJ O
+is AUX O
+a DET O
+key ADJ O
+component NOUN O
+in ADP O
+a DET O
+developmental ADJ O
+pathway NOUN O
+regulating VERB O
+the DET O
+specification NOUN O
+of ADP O
+the DET O
+root NOUN O
+stem NOUN O
+cell NOUN O
+niche NOUN O
+as ADP O
+well ADV O
+as ADP O
+the DET O
+radial ADJ O
+patterning NOUN O
+of ADP O
+the DET O
+root NOUN O
+in ADP O
+Arabidopsis PROPN O
+[ PUNCT O
+6 NUM O
+– SYM O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+Then ADV O
+we PRON O
+measured VERB O
+the DET O
+evoked VERB O
+EPSCs NOUN O
+( PUNCT O
+eEPSCs NOUN B-AC
+) PUNCT O
+in ADP O
+pyramidal ADJ O
+neurons NOUN O
+( PUNCT O
+Fig PROPN O
+2H NUM O
+) PUNCT O
+. PUNCT O
+We PRON O
+confirmed VERB O
+that SCONJ O
+the DET O
+evoked VERB O
+currents NOUN O
+were AUX O
+truly ADV O
+AMPAR- NOUN B-AC
+and CCONJ O
+N NOUN B-LF
+- PUNCT I-LF
+methyl NOUN I-LF
+- PUNCT I-LF
+D NOUN I-LF
+- PUNCT I-LF
+aspartic ADJ I-LF
+acid NOUN I-LF
+receptor NOUN I-LF
+( PUNCT O
+NMDAR)-mediated PROPN B-AC
+currents NOUN O
+by ADP O
+using VERB O
+AMPAR- NOUN B-AC
+and CCONJ O
+NMDAR PROPN B-AC
+- PUNCT O
+specific ADJ O
+antagonists NOUN O
+6 NUM B-LF
+- PUNCT I-LF
+cyano-7 NOUN I-LF
+- PUNCT I-LF
+nitroquinoxaline-2,3 NOUN I-LF
+- PUNCT I-LF
+dione NOUN I-LF
+( PUNCT O
+CNQX PROPN B-AC
+) PUNCT O
+and CCONJ O
+DL-2 PROPN B-LF
+- PUNCT I-LF
+Amino-5 NOUN I-LF
+- PUNCT I-LF
+phosphonopentanoic NOUN I-LF
+acid NOUN I-LF
+( PUNCT O
+DL PROPN B-AC
+- PUNCT B-AC
+AP5 PROPN B-AC
+) PUNCT O
+, PUNCT O
+respectively ADV O
+( PUNCT O
+S5A PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+The DET O
+thickness NOUN O
+of ADP O
+retinal ADJ O
+layers NOUN O
+{ PUNCT O
+retinal ADJ B-LF
+nerve NOUN I-LF
+fiber NOUN I-LF
+layer NOUN I-LF
+( PUNCT O
+RNFL PROPN B-AC
+) PUNCT O
+, PUNCT O
+ganglion NOUN B-LF
+cell NOUN I-LF
+layer NOUN I-LF
+plus CCONJ I-LF
+inner ADJ I-LF
+plexiform ADJ I-LF
+layer NOUN I-LF
+( PUNCT O
+GCLIPL PROPN B-AC
+) PUNCT O
+, PUNCT O
+RNFL PROPN B-AC
+plus CCONJ O
+GCLIPL PROPN B-AC
+( PUNCT O
+ganglion NOUN B-LF
+cell NOUN I-LF
+complex NOUN I-LF
+, PUNCT O
+GCC PROPN B-AC
+) PUNCT O
+, PUNCT O
+total ADJ O
+retina NOUN O
+, PUNCT O
+total ADJ O
+retina NOUN O
+minus CCONJ O
+GCC PROPN B-AC
+( PUNCT O
+outer ADJ O
+retina NOUN O
+) PUNCT O
+} PUNCT O
+were AUX O
+measured VERB O
+by ADP O
+macular ADJ O
+scans NOUN O
+( PUNCT O
+RS-3000 PROPN O
+, PUNCT O
+NIDEK PROPN O
+) PUNCT O
+in ADP O
+202 NUM O
+eyes NOUN O
+of ADP O
+202 NUM O
+normal ADJ O
+Asian ADJ O
+subjects NOUN O
+aged VERB O
+20 NUM O
+to PART O
+60 NUM O
+years NOUN O
+. PUNCT O
+
+We PRON O
+and CCONJ O
+others NOUN O
+have AUX O
+used VERB O
+human ADJ B-LF
+pluripotent ADJ I-LF
+stem NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+hPSCs PROPN B-AC
+) PUNCT O
+to PART O
+demonstrate VERB O
+that SCONJ O
+BMP4 PROPN B-AC
+treatment NOUN O
+of ADP O
+geometrically ADV O
+confined VERB O
+hPSC PROPN B-AC
+colonies NOUN O
+recapitulate VERB O
+aspects NOUN O
+of ADP O
+human ADJ O
+peri NOUN O
+- NOUN O
+gastrulation NOUN O
+– PUNCT O
+like ADJ O
+organized VERB O
+fate NOUN O
+patterning NOUN O
+[ PUNCT O
+24–26 NUM O
+] PUNCT O
+. PUNCT O
+
+c X O
+RA NOUN B-AC
+/ SYM O
+CLA NOUN B-AC
+, PUNCT O
+Rumenic ADJ B-LF
+acid NOUN I-LF
+/ SYM O
+Conjugated VERB B-LF
+linoleic ADJ I-LF
+acid NOUN I-LF
+. PUNCT O
+
+The DET O
+mean ADJ O
+age NOUN O
+of ADP O
+mothers NOUN O
+when SCONJ O
+the DET O
+study NOUN O
+children NOUN O
+were AUX O
+born VERB O
+was AUX O
+29.6 NUM O
+years NOUN O
+( PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+[ PUNCT O
+SD NOUN B-AC
+] PUNCT O
+, PUNCT O
+5.7 NUM O
+) PUNCT O
+and CCONJ O
+the DET O
+median ADJ O
+age NOUN O
+was AUX O
+30 NUM O
+years NOUN O
+( PUNCT O
+interquartile ADJ B-LF
+range NOUN I-LF
+[ PUNCT O
+IQR NOUN B-AC
+] PUNCT O
+, PUNCT O
+26–34 NUM O
+; PUNCT O
+range NOUN O
+, PUNCT O
+13–56 NUM O
+) PUNCT O
+. PUNCT O
+
+CD4+CD25+FoxP3 NOUN O
++ NOUN O
+IL-10 NOUN O
+– VERB O
+producing VERB O
+natural ADJ O
+T NOUN B-LF
+regulatory ADJ I-LF
+cells NOUN I-LF
+( PUNCT O
+Tregs NOUN B-AC
+) PUNCT O
+have AUX O
+been AUX O
+elegantly ADV O
+shown VERB O
+to PART O
+control VERB O
+parasite NOUN O
+survival NOUN O
+[ PUNCT O
+44,45 NUM O
+] PUNCT O
+. PUNCT O
+
+More ADJ O
+than ADP O
+15 NUM O
+% NOUN O
+of ADP O
+patients NOUN O
+presenting VERB O
+with ADP O
+mixed ADJ O
+infection NOUN O
+of ADP O
+P. PROPN O
+falciparum NOUN O
+and CCONJ O
+P. PROPN O
+vivax NOUN O
+had VERB O
+P. PROPN O
+vivax NOUN O
+parasitaemia NOUN O
+within ADP O
+42 NUM O
+days NOUN O
+, PUNCT O
+supporting VERB O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+recommendation NOUN O
+for ADP O
+the DET O
+use NOUN O
+of ADP O
+primaquine NOUN O
+radical NOUN O
+cure NOUN O
+in ADP O
+these DET O
+patients NOUN O
+. PUNCT O
+
+A X O
+) PUNCT O
+LC3II PROPN O
+B X O
+) PUNCT O
+LC3I PROPN O
+protein NOUN O
+content NOUN O
+, PUNCT O
+C X O
+) PUNCT O
+LC3II PROPN O
+/ SYM O
+LC3I PROPN O
+Ratio NOUN O
+and CCONJ O
+D X O
+) PUNCT O
+P62 NOUN O
+protein NOUN O
+content NOUN O
+from ADP O
+PGC-1α NOUN B-AC
+knockout NOUN B-LF
+( PUNCT O
+KO PROPN B-AC
+) PUNCT O
+and CCONJ O
+littermate NOUN O
+wildtype NOUN B-LF
+( PUNCT O
+WT PROPN B-AC
+) PUNCT O
+control NOUN O
+mice NOUN O
+at ADP O
+rest NOUN O
+( PUNCT O
+REST NOUN B-AC
+) PUNCT O
+, PUNCT O
+3h NUM O
+and CCONJ O
+6h NUM O
+after ADP O
+a DET O
+single ADJ O
+treadmill NOUN O
+exercise NOUN O
+bout NOUN O
+at ADP O
+either CCONJ O
+low ADJ O
+intensity NOUN O
+( PUNCT O
+LI PROPN B-AC
+) PUNCT O
+or CCONJ O
+moderate ADJ O
+intensity NOUN O
+( PUNCT O
+MI PROPN B-AC
+) PUNCT O
+. PUNCT O
+Values NOUN O
+are AUX O
+mean ADJ O
+±SE NOUN O
+, PUNCT O
+n NOUN O
+= SYM O
+8 NUM O
+. PUNCT O
+* PUNCT O
+Significantly ADV O
+different ADJ O
+from ADP O
+REST NOUN B-AC
+within ADP O
+given VERB O
+genotype NOUN O
+( PUNCT O
+p<0.05 NUM O
+) PUNCT O
+. PUNCT O
+¤ PUNCT O
+Significantly ADV O
+different ADJ O
+from ADP O
+LI PROPN B-AC
+within ADP O
+given VERB O
+genotype NOUN O
+( PUNCT O
+p<0.05 NUM O
+) PUNCT O
+. PUNCT O
+# PUNCT O
+Significantly ADV O
+different ADJ O
+from ADP O
+WT PROPN B-AC
+within ADP O
+given VERB O
+group NOUN O
+( PUNCT O
+p<0.05 NUM O
+) PUNCT O
+. PUNCT O
+
+Flow NOUN O
+cytometry NOUN O
+analysis NOUN O
+of ADP O
+uterine ADJ O
+implantation NOUN O
+sites NOUN O
+following VERB O
+removal NOUN O
+of ADP O
+the DET O
+placenta NOUN O
+/ SYM O
+embryo NOUN O
+demonstrated VERB O
+that SCONJ O
+the DET O
+percentage NOUN O
+of ADP O
+BM PROPN B-AC
+- NOUN O
+derived VERB O
+GFP+ PROPN B-AC
+cells NOUN O
+in ADP O
+the DET O
+implantation NOUN O
+site NOUN O
+increased VERB O
+as ADP O
+pregnancy NOUN O
+progressed VERB O
+to ADP O
+mid NOUN O
+- NOUN O
+gestation NOUN O
+; PUNCT O
+it PRON O
+increased VERB O
+significantly ADV O
+on ADP O
+the DET O
+day NOUN O
+of ADP O
+implantation NOUN O
+( PUNCT O
+E5.5 NUM O
+) PUNCT O
+( PUNCT O
+15.8 NUM O
+% NOUN O
+) PUNCT O
+as ADP O
+compared VERB O
+with ADP O
+the DET O
+nonpregnant ADJ O
+state NOUN O
+( PUNCT O
+9.2 NUM O
+% NOUN O
+) PUNCT O
+, PUNCT O
+peaking VERB O
+on ADP O
+E9.5 NUM O
+( PUNCT O
+24.1 NUM O
+% NOUN O
+) PUNCT O
+, PUNCT O
+followed VERB O
+by ADP O
+a DET O
+gradual ADJ O
+decrease NOUN O
+on ADP O
+E13.5 NOUN O
+( PUNCT O
+16.7 NUM O
+% NOUN O
+) PUNCT O
+and CCONJ O
+peripartum NOUN O
+( PUNCT O
+E17.5 NUM O
+) PUNCT O
+( PUNCT O
+13.1 NUM O
+% NOUN O
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+1D NUM O
+and CCONJ O
+1F NOUN O
+) PUNCT O
+. PUNCT O
+As SCONJ O
+the DET O
+observed VERB O
+increase NOUN O
+in ADP O
+GFP+ PROPN B-AC
+cells NOUN O
+in ADP O
+the DET O
+decidua NOUN O
+during ADP O
+pregnancy NOUN O
+could AUX O
+be AUX O
+due ADJ O
+to ADP O
+local ADJ O
+proliferation NOUN O
+of ADP O
+BMDCs NOUN B-AC
+and CCONJ O
+not PART O
+only ADV O
+to ADP O
+increased VERB O
+recruitment NOUN O
+, PUNCT O
+we PRON O
+assessed VERB O
+cell NOUN O
+proliferation NOUN O
+using VERB O
+proliferating VERB B-LF
+cell NOUN I-LF
+nuclear ADJ I-LF
+antigen NOUN I-LF
+( PUNCT O
+PCNA PROPN B-AC
+) PUNCT O
+staining NOUN O
+. PUNCT O
+
+The DET O
+diagnosis NOUN O
+of ADP O
+sepsis NOUN O
+was AUX O
+made VERB O
+according VERB O
+to ADP O
+the DET O
+criteria NOUN O
+of ADP O
+the DET O
+American PROPN B-LF
+College PROPN I-LF
+of ADP I-LF
+Chest PROPN I-LF
+Physicians PROPN I-LF
+/ SYM O
+Society PROPN B-LF
+of ADP I-LF
+Critical PROPN I-LF
+Care PROPN I-LF
+Medicine PROPN I-LF
+( PUNCT O
+ACCP PROPN B-AC
+- PUNCT O
+SCCM PROPN B-AC
+) PUNCT O
+consensus NOUN O
+conference NOUN O
+committee NOUN O
+[ PUNCT O
+15 NUM O
+, PUNCT O
+16 NUM O
+] PUNCT O
+and CCONJ O
+MOF PROPN B-AC
+was AUX O
+defined VERB O
+as ADP O
+simultaneous ADJ O
+failure NOUN O
+of ADP O
+least ADV O
+two NUM O
+organs NOUN O
+. PUNCT O
+
+New ADJ O
+appearance NOUN O
+of ADP O
+contrast NOUN B-LF
+enhancement NOUN I-LF
+( PUNCT O
+CE NOUN B-AC
+) PUNCT O
+in ADP O
+magnetic ADJ B-LF
+resonance NOUN I-LF
+imaging NOUN I-LF
+( PUNCT O
+MRI PROPN B-AC
+) PUNCT O
+follow NOUN O
+- PUNCT O
+up NOUN O
+is AUX O
+currently ADV O
+the DET O
+established VERB O
+imaging NOUN O
+feature NOUN O
+related VERB O
+to ADP O
+MT NOUN B-AC
+[ X O
+7,8 NUM O
+] PUNCT O
+, PUNCT O
+especially ADV O
+if SCONJ O
+no DET O
+recent ADJ O
+therapy NOUN O
+has AUX O
+been AUX O
+administered VERB O
+. PUNCT O
+
+Data NOUN O
+are AUX O
+indicated VERB O
+as ADP O
+mean ADJ O
+concentrations NOUN O
+of ADP O
+biogenic ADJ O
+amines NOUN O
+( PUNCT O
+dopamine NOUN B-LF
+, PUNCT O
+DA PROPN B-AC
+; PUNCT O
+norepinephrine NOUN B-LF
+, PUNCT O
+NE PROPN B-AC
+; PUNCT O
+5 NUM O
+- PUNCT O
+hydroxytryptamine NOUN O
+, PUNCT O
+5 NUM B-AC
+- PUNCT B-AC
+HT NOUN B-AC
+) PUNCT O
+and CCONJ O
+metabolites NOUN O
+( PUNCT O
+3 NUM B-LF
+- PUNCT I-LF
+4 NUM I-LF
+- PUNCT I-LF
+Dihydroxyphenylacetic NOUN I-LF
+acid NOUN I-LF
+, PUNCT O
+DOPAC PROPN B-AC
+; PUNCT O
+homovanillic ADJ B-LF
+acid NOUN I-LF
+, PUNCT O
+HVA PROPN B-AC
+; PUNCT O
+3 NUM B-LF
+- PUNCT I-LF
+methoxy-4 NOUN I-LF
+hydroxyphenylethyleneglycol NOUN I-LF
+, PUNCT O
+MHPG PROPN B-AC
+; PUNCT O
+5 NUM O
+- PUNCT O
+hydroxyindoleacetic ADJ O
+acid NOUN O
+, PUNCT O
+5 NUM B-AC
+- PUNCT B-AC
+HIAA NOUN B-AC
+) PUNCT O
+±ES NOUN O
+. PUNCT O
+
+In ADP O
+order NOUN O
+to PART O
+improve VERB O
+the DET O
+contrast NOUN O
+of ADP O
+the DET O
+soft ADJ O
+tissues NOUN O
+, PUNCT O
+the DET O
+sample NOUN O
+was AUX O
+stained VERB O
+with ADP O
+0.3 NUM O
+% NOUN O
+phosphotungstic ADJ B-LF
+acid NOUN I-LF
+solution NOUN O
+( PUNCT O
+PTA PROPN B-AC
+; PUNCT O
+Sigma PROPN O
+Aldrich PROPN O
+) PUNCT O
+in ADP O
+70 NUM O
+% NOUN O
+ethanol NOUN O
+for ADP O
+6.5 NUM O
+days NOUN O
+. PUNCT O
+
+In ADP O
+Drosophila PROPN O
+, PUNCT O
+the DET O
+Hh PROPN O
+signal NOUN O
+is AUX O
+transduced VERB O
+through ADP O
+a DET O
+receptor NOUN O
+system NOUN O
+at ADP O
+the DET O
+plasma NOUN O
+membrane NOUN O
+, PUNCT O
+which PRON O
+includes VERB O
+the DET O
+receptor NOUN O
+complex NOUN O
+Patched PROPN B-LF
+- PUNCT I-LF
+Interference PROPN I-LF
+Hh PROPN I-LF
+( PUNCT O
+Ptc NOUN B-AC
+- PUNCT B-AC
+Ihog PROPN B-AC
+) PUNCT O
+and CCONJ O
+the DET O
+signal NOUN O
+transducer NOUN O
+Smo PROPN B-AC
+[ X O
+4–6 NUM O
+] PUNCT O
+. PUNCT O
+
+PCa NOUN B-AC
+, PUNCT O
+prostate NOUN B-LF
+cancer NOUN I-LF
+. PUNCT O
+
+Active ADJ O
+Case NOUN O
+Finding NOUN O
+for ADP O
+Tuberculosis NOUN B-LF
+through ADP O
+TOUCH NOUN O
+Agents NOUN O
+in ADP O
+Selected VERB O
+High ADJ O
+TB NOUN B-AC
+Burden NOUN O
+Wards NOUN O
+of ADP O
+Kolkata PROPN O
+, PUNCT O
+India PROPN O
+: PUNCT O
+A DET O
+Mixed ADJ O
+Methods NOUN O
+Study NOUN O
+on ADP O
+Outcomes NOUN O
+and CCONJ O
+Implementation NOUN O
+Challenges NOUN O
+. PUNCT O
+
+The DET O
+59 NUM O
+microorganisms NOUN O
+were AUX O
+automatically ADV O
+mapped VERB O
+between ADP O
+datasets NOUN O
+of ADP O
+MKD PROPN B-AC
+and CCONJ O
+Pfam PROPN B-AC
+using VERB O
+the DET O
+National PROPN B-LF
+Center PROPN I-LF
+for ADP I-LF
+Biotechnology PROPN I-LF
+Information PROPN I-LF
+'s PART O
+( PUNCT O
+NCBI PROPN B-AC
+) PUNCT O
+taxons NOUN O
+as ADP O
+a DET O
+reference NOUN O
+, PUNCT O
+followed VERB O
+by ADP O
+manual ADJ O
+examination NOUN O
+by ADP O
+experts NOUN O
+( PUNCT O
+Figure PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+For ADP O
+example NOUN O
+, PUNCT O
+P63 PROPN O
+regulates VERB O
+growth NOUN O
+, PUNCT O
+invasion NOUN O
+and CCONJ O
+metastasis NOUN O
+of ADP O
+esophageal ADJ B-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+( PUNCT O
+ESCC PROPN B-AC
+) PUNCT O
+cells NOUN O
+[ PUNCT O
+7 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+Sox2 PROPN O
+functions VERB O
+as ADP O
+an DET O
+amplified ADJ O
+lineage NOUN O
+- PUNCT O
+survival NOUN O
+oncogene NOUN O
+in ADP O
+ESCC PROPN B-AC
+[ PUNCT O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+PCR NOUN B-AC
+, PUNCT O
+polymerase NOUN B-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+. PUNCT O
+
+We PRON O
+calculated VERB O
+the DET O
+mean ADJ O
+BMI NOUN B-AC
+, PUNCT O
+mean ADJ O
+waist NOUN B-LF
+circumference NOUN I-LF
+( PUNCT O
+WC PROPN B-AC
+) PUNCT O
+and CCONJ O
+odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+ORs NOUN B-AC
+) PUNCT O
+for ADP O
+BMI NOUN B-AC
+comparing VERB O
+the DET O
+lowest ADJ O
+life NOUN O
+course NOUN O
+SES PROPN B-AC
+category NOUN O
+with ADP O
+the DET O
+highest ADJ O
+life NOUN O
+course NOUN O
+SES PROPN B-AC
+category NOUN O
+for ADP O
+each DET O
+study NOUN O
+. PUNCT O
+
+X NOUN O
+- NOUN O
+ray NOUN O
+diffraction NOUN O
+studies NOUN O
+guided VERB O
+by ADP O
+nuclear ADJ B-LF
+magnetic ADJ I-LF
+resonance NOUN I-LF
+( PUNCT O
+NMR PROPN B-AC
+) PUNCT O
+experiments NOUN O
+reveal VERB O
+the DET O
+crystal NOUN O
+structures NOUN O
+of ADP O
+the DET O
+Munc13–1 PROPN O
+C NOUN O
+2A NOUN O
+- NOUN O
+domain NOUN O
+homodimer NOUN O
+and CCONJ O
+the DET O
+Munc13–1 PROPN O
+C NOUN O
+2A NOUN O
+- NOUN O
+domain NOUN O
+/ SYM O
+RIM PROPN O
+ZF PROPN B-AC
+heterodimer NOUN O
+at ADP O
+1.44 NUM O
+Å NOUN O
+and CCONJ O
+1.78 NUM O
+Å NOUN O
+resolution NOUN O
+, PUNCT O
+respectively ADV O
+. PUNCT O
+
+In ADP O
+the DET O
+first ADJ O
+stage NOUN O
+, PUNCT O
+we PRON O
+analyzed VERB O
+Y PROPN B-LF
+- ADJ I-LF
+chromosome NOUN I-LF
+short ADJ I-LF
+tandem NOUN I-LF
+repeat NOUN I-LF
+( PUNCT O
+Y PROPN B-AC
+- ADJ B-AC
+STR PROPN B-AC
+) PUNCT O
+and CCONJ O
+mtDNA NOUN B-AC
+hyper ADJ B-LF
+variable NOUN I-LF
+segment NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+HVS1 NOUN B-AC
+) PUNCT O
+sequence NOUN O
+data NOUN O
+from ADP O
+two NUM O
+groups NOUN O
+of ADP O
+Indian ADJ O
+tribes NOUN O
+, PUNCT O
+comprised VERB O
+of ADP O
+five NUM O
+populations NOUN O
+each PRON O
+, PUNCT O
+belonging VERB O
+to ADP O
+a DET O
+broad ADJ O
+linguistic ADJ O
+family NOUN O
+and CCONJ O
+with ADP O
+similar ADJ O
+socio ADJ O
+- ADJ O
+economic ADJ O
+status NOUN O
+. PUNCT O
+
+Small ADJ B-LF
+for ADP I-LF
+gestational ADJ I-LF
+age NOUN I-LF
+( PUNCT O
+SGA PROPN B-AC
+) PUNCT O
+was AUX O
+defined VERB O
+as ADP O
+a DET O
+BW NOUN B-AC
+less ADJ O
+than ADP O
+the DET O
+10th ADJ O
+percentile NOUN O
+of ADP O
+the DET O
+standard ADJ O
+BW NOUN B-AC
+for ADP O
+gestational ADJ O
+age NOUN O
+published VERB O
+by ADP O
+the DET O
+Japan PROPN O
+Pediatric PROPN O
+Society PROPN O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+CI NOUN B-AC
+: PUNCT O
+Confidence NOUN B-LF
+interval NOUN I-LF
+
+KCMC PROPN B-AC
+= PUNCT O
+Kilimanjaro PROPN B-LF
+Christian PROPN I-LF
+Medical PROPN I-LF
+Center PROPN I-LF
+. PUNCT O
+Data NOUN O
+were AUX O
+analyzed VERB O
+with ADP O
+Pearson PROPN O
+Chi PROPN O
+Square PROPN O
+and CCONJ O
+student NOUN O
+t NOUN O
+tests NOUN O
+where SCONJ O
+appropriate ADJ O
+. PUNCT O
+
+The DET O
+genotype NOUN O
+AA NOUN O
+of ADP O
+the DET O
+rs4730153 NOUN O
+SNP NOUN O
+was AUX O
+significantly ADV O
+associated VERB O
+with ADP O
+fasting VERB O
+glucose NOUN O
+, PUNCT O
+fasting VERB O
+insulin NOUN O
+and CCONJ O
+HOMA NOUN B-AC
+- PUNCT B-AC
+IR PROPN B-AC
+( PUNCT O
+Homeostasis NOUN O
+model NOUN O
+assessment NOUN O
+- PUNCT O
+insulin NOUN B-LF
+resistance NOUN I-LF
+) PUNCT O
+after ADP O
+adjustment NOUN O
+for ADP O
+gender NOUN O
+, PUNCT O
+age NOUN O
+, PUNCT O
+BMI NOUN B-AC
+and CCONJ O
+waist NOUN O
+circumference NOUN O
+. PUNCT O
+
+PER NOUN B-AC
+oscillations NOUN O
+in ADP O
+the DET O
+fifth ADJ O
+s NOUN B-AC
+- PUNCT B-AC
+LNv NOUN B-AC
+were AUX O
+therefore ADV O
+expected VERB O
+to PART O
+peak VERB O
+around ADP O
+circadian ADJ O
+time NOUN O
+( PUNCT O
+CT)57–58 NUM O
+in ADP O
+the DET O
+third ADJ O
+day NOUN O
+of ADP O
+LL PROPN B-AC
+if SCONJ O
+the DET O
+EO NOUN B-AC
+oscillator NOUN O
+runs VERB O
+with ADP O
+a DET O
+22.8 NUM O
+- PUNCT O
+h NOUN O
+period NOUN B-LF
+( PUNCT O
+see VERB O
+Table PROPN O
+2 NUM O
+) PUNCT O
+. PUNCT O
+
+A DET O
+fraction NOUN O
+of ADP O
+EpiCs PROPN B-AC
+undergo VERB O
+epithelial ADJ B-LF
+- ADJ I-LF
+to ADP I-LF
+- ADJ I-LF
+mesenchymal ADJ I-LF
+transition NOUN I-LF
+( PUNCT O
+EMT PROPN B-AC
+) PUNCT O
+, PUNCT O
+giving VERB O
+rise NOUN O
+to ADP O
+epicardial ADJ B-LF
+- ADJ I-LF
+derived VERB I-LF
+cells NOUN I-LF
+( PUNCT O
+EPDCs PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+migrate VERB O
+into ADP O
+the DET O
+myocardium NOUN O
+and CCONJ O
+generate VERB O
+peri ADJ O
+- ADJ O
+vascular ADJ O
+smooth ADJ B-LF
+muscle NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+SMCs PROPN B-AC
+) PUNCT O
+[ X O
+4 NUM O
+] PUNCT O
+and CCONJ O
+fibroblasts NOUN B-LF
+( PUNCT O
+FBs NOUN B-AC
+) PUNCT O
+[ X O
+5,6 NUM O
+] PUNCT O
+. PUNCT O
+
+LAIV PROPN B-AC
+, PUNCT O
+live ADJ B-LF
+attenuated VERB I-LF
+influenza NOUN I-LF
+vaccine NOUN I-LF
+. PUNCT O
+
+NK PROPN B-AC
+, PUNCT O
+natural ADJ B-LF
+killer NOUN I-LF
+; PUNCT O
+PBMC PROPN B-AC
+, PUNCT O
+peripheral ADJ B-LF
+blood NOUN I-LF
+mononuclear ADJ I-LF
+cell NOUN I-LF
+. PUNCT O
+
+The DET O
+dashed ADJ O
+line NOUN O
+represents VERB O
+the DET O
+level NOUN O
+of ADP O
+inoculation NOUN O
+at ADP O
+t NOUN O
+= SYM O
+0 NUM O
+h NOUN O
+( PUNCT O
+104 NUM O
+CFUs NOUN B-AC
+per ADP O
+mL NOUN O
+) PUNCT O
+. PUNCT O
+ApWJL PROPN B-AC
+, PUNCT O
+A. NOUN O
+pomorumWJL NOUN O
+; PUNCT O
+CFU PROPN B-AC
+, PUNCT O
+colony NOUN B-LF
+- PUNCT I-LF
+forming VERB I-LF
+unit NOUN I-LF
+; PUNCT O
+EAAFly PROPN B-AC
+, PUNCT O
+fly NOUN B-LF
+essential ADJ I-LF
+amino NOUN I-LF
+acid NOUN I-LF
+; PUNCT O
+HD PROPN B-AC
+, PUNCT O
+Holidic PROPN B-LF
+Diet PROPN I-LF
+; PUNCT O
+LpNC8 PROPN B-AC
+, PUNCT O
+L. NOUN O
+plantarumNC8 NOUN O
+; PUNCT O
+NALs PROPN B-AC
+, PUNCT O
+nucleic ADJ O
+acids NOUN O
+and CCONJ O
+lipids NOUN O
+; PUNCT O
+NEAAFLY PROPN O
+, PUNCT O
+fly NOUN O
+nonessential ADJ O
+amino NOUN O
+acid NOUN O
+; PUNCT O
+ODMax PROPN B-AC
+, PUNCT O
+maximal ADJ B-LF
+optical ADJ I-LF
+density NOUN I-LF
+. PUNCT O
+
+BZD PROPN B-AC
+, PUNCT O
+benzodiazepine NOUN B-LF
+or CCONJ I-LF
+benzodiazepine NOUN I-LF
+- PUNCT I-LF
+related VERB I-LF
+drug NOUN I-LF
+. PUNCT O
+
+Patients NOUN O
+with ADP O
+DCB PROPN B-AC
+displayed VERB O
+a DET O
+higher ADJ O
+proportion NOUN O
+of ADP O
+tumor NOUN B-LF
+- PUNCT I-LF
+infiltrating VERB I-LF
+T PROPN I-LF
+lymphocytes NOUN I-LF
+( PUNCT O
+TIL PROPN B-AC
+) PUNCT O
+( PUNCT O
+n NOUN O
+= SYM O
+24 NUM O
+, PUNCT O
+Mann PROPN O
+- PUNCT O
+Whitney PROPN O
+p NOUN O
+= SYM O
+0.047 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+highest ADJ O
+homology NOUN O
+is AUX O
+with ADP O
+a DET O
+16/17 NUM O
+- PUNCT O
+base NOUN B-LF
+pair NOUN I-LF
+( PUNCT O
+bp NOUN B-AC
+) PUNCT O
+match NOUN O
+to ADP O
+OL2 NOUN O
+, PUNCT O
+and CCONJ O
+it PRON O
+occurs VERB O
+within ADP O
+the DET O
+open ADJ O
+reading NOUN O
+frame NOUN O
+of ADP O
+rlpB NOUN O
+, PUNCT O
+a DET O
+gene NOUN O
+coding VERB O
+for ADP O
+an DET O
+inner ADJ O
+membrane NOUN O
+lipoprotein NOUN O
+. PUNCT O
+
+We PRON O
+previously ADV O
+showed VERB O
+that SCONJ O
+bone NOUN B-LF
+marrow NOUN I-LF
+- PUNCT I-LF
+derived VERB I-LF
+macrophages NOUN I-LF
+( PUNCT O
+BMMs PROPN B-AC
+) PUNCT O
+from ADP O
+sg NOUN B-AC
+/ SYM B-AC
+sg NOUN B-AC
+mice NOUN O
+displayed VERB O
+significantly ADV O
+reduced VERB O
+mRNA NOUN B-AC
+expression NOUN O
+of ADP O
+Ch25h NOUN B-AC
+and CCONJ O
+deficient ADJ O
+phagocytosis NOUN O
+[ PUNCT O
+23 NUM O
+] PUNCT O
+. PUNCT O
+
+BI PROPN B-AC
+, PUNCT O
+Barthel PROPN B-LF
+Index NOUN I-LF
+; PUNCT O
+IS PROPN B-AC
+, PUNCT O
+ischaemic ADJ B-LF
+stroke NOUN I-LF
+. PUNCT O
+
+We PRON O
+assessed VERB O
+risk NOUN O
+of ADP O
+bias NOUN O
+for ADP O
+each DET O
+key ADJ O
+outcome NOUN O
+using VERB O
+the DET O
+Grading PROPN B-LF
+of ADP I-LF
+Recommendations PROPN I-LF
+Assessment PROPN I-LF
+, PUNCT I-LF
+Development PROPN I-LF
+and CCONJ I-LF
+Evaluation PROPN I-LF
+( PUNCT O
+GRADE PROPN B-AC
+) PUNCT O
+approach NOUN O
+[ PUNCT O
+28 NUM O
+] PUNCT O
+and CCONJ O
+created VERB O
+‘ PUNCT O
+Summary PROPN O
+of ADP O
+findings NOUN O
+’ PUNCT O
+tables NOUN O
+using VERB O
+GRADEpro PROPN O
+Guideline PROPN O
+Development PROPN O
+Tool PROPN O
+[ PUNCT O
+29 NUM O
+] PUNCT O
+. PUNCT O
+
+Here ADV O
+we PRON O
+compared VERB O
+the DET O
+expression NOUN O
+profile NOUN O
+of ADP O
+lncRNAs NOUN B-AC
+in ADP O
+cold ADJ O
+acclimated VERB O
+zebrafish NOUN B-LF
+embryonic ADJ I-LF
+fibroblast NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+ZF4 PROPN B-AC
+) PUNCT O
+cultured VERB O
+at ADP O
+18 NUM O
+° NOUN O
+C NOUN O
+for ADP O
+30 NUM O
+days NOUN O
+with ADP O
+that PRON O
+of ADP O
+cells NOUN O
+cultured VERB O
+at ADP O
+28 NUM O
+° NOUN O
+C NOUN O
+as ADP O
+control NOUN O
+by ADP O
+high ADJ O
+- PUNCT O
+throughput NOUN O
+sequencing NOUN O
+. PUNCT O
+
+Multidrug NOUN B-LF
+- PUNCT I-LF
+resistant ADJ I-LF
+tuberculosis NOUN I-LF
+( PUNCT O
+MDR PROPN B-AC
+- PUNCT B-AC
+TB PROPN B-AC
+) PUNCT O
+is AUX O
+an DET O
+important ADJ O
+global ADJ O
+health NOUN O
+problem NOUN O
+, PUNCT O
+and CCONJ O
+a DET O
+control NOUN O
+strategy NOUN O
+known VERB O
+as ADP O
+DOTS PROPN O
+- PUNCT O
+Plus PROPN O
+has AUX O
+existed VERB O
+since SCONJ O
+1999 NUM O
+. PUNCT O
+
+transcription NOUN B-LF
+termination NOUN I-LF
+/ SYM I-LF
+antitermination NOUN I-LF
+protein NOUN I-LF
+nusG NOUN I-LF
+
+Minc NOUN B-AC
+= PUNCT O
+motor NOUN B-LF
+incongruence NOUN I-LF
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+GLP-1 PROPN B-AC
+, PUNCT O
+glucagon NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+peptide NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+n NOUN O
+/ SYM O
+a NOUN O
+, PUNCT O
+not PART O
+applicable ADJ O
+; PUNCT O
+PYY3 NOUN B-AC
+- PUNCT B-AC
+36 NUM B-AC
+, PUNCT O
+peptide NOUN B-LF
+YY3 NOUN I-LF
+- PUNCT I-LF
+36 NUM I-LF
+. PUNCT O
+
+The DET O
+objective NOUN O
+of ADP O
+the DET O
+present ADJ O
+study NOUN O
+was AUX O
+to PART O
+evaluate VERB O
+the DET O
+efficacy NOUN O
+of ADP O
+the DET O
+Attempted PROPN B-LF
+Suicide PROPN I-LF
+Short PROPN I-LF
+Intervention PROPN I-LF
+Program PROPN I-LF
+( PUNCT O
+ASSIP PROPN B-AC
+) PUNCT O
+in ADP O
+reducing VERB O
+suicidal ADJ O
+behavior NOUN O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+in ADP O
+498 NUM O
+( PUNCT O
+37.4 NUM O
+% NOUN O
+) PUNCT O
+patients NOUN O
+who PRON O
+had VERB O
+available ADJ O
+b ADJ B-LF
+- ADJ I-LF
+type NOUN I-LF
+natriuretic ADJ I-LF
+peptide NOUN I-LF
+( PUNCT O
+BNP PROPN B-AC
+) PUNCT O
+measurements NOUN O
+, PUNCT O
+the DET O
+added VERB O
+value NOUN O
+of ADP O
+CSI PROPN B-AC
+on ADP O
+the DET O
+top NOUN O
+of ADP O
+the DET O
+Brest PROPN O
+score NOUN O
+and CCONJ O
+BNP PROPN B-AC
+was AUX O
+assessed VERB O
+. PUNCT O
+
+We PRON O
+compared VERB O
+the DET O
+activities NOUN O
+of ADP O
+wild ADJ B-LF
+type NOUN I-LF
+eNOS PROPN I-LF
+( PUNCT O
+WT PROPN B-AC
+eNOS PROPN B-AC
+) PUNCT O
+and CCONJ O
+S1179D NOUN B-AC
+eNOS PROPN B-AC
+by ADP O
+measuring VERB O
+the DET O
+L-[C14]arginine NOUN O
+to ADP O
+L-[C14]citrulline NOUN O
+conversion NOUN O
+rate NOUN O
+. PUNCT O
+
+A DET O
+literature NOUN O
+review NOUN O
+reveals VERB O
+two NUM O
+studies NOUN O
+only ADV O
+: PUNCT O
+One NUM O
+focusing VERB O
+on ADP O
+prostasomes NOUN O
+from ADP O
+seminal ADJ O
+fluid NOUN O
+isolated VERB O
+by ADP O
+sequential ADJ B-LF
+ultracentrifugation NOUN I-LF
+( PUNCT O
+SUC PROPN B-AC
+) PUNCT O
+, PUNCT O
+size NOUN B-LF
+exclusion NOUN I-LF
+chromatography NOUN I-LF
+( PUNCT O
+SEC PROPN B-AC
+) PUNCT O
+and CCONJ O
+sucrose NOUN B-LF
+gradient NOUN I-LF
+( PUNCT O
+SG NOUN B-AC
+) PUNCT O
+followed VERB O
+by ADP O
+lipid NOUN O
+analysis NOUN O
+by ADP O
+LC PROPN B-AC
+- PUNCT B-AC
+MS PROPN B-AC
+[ PUNCT O
+35 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+flagellation NOUN O
+levels NOUN O
+of ADP O
+the DET O
+FliK PROPN O
+mutants NOUN O
+were AUX O
+not PART O
+significantly ADV O
+different ADJ O
+, PUNCT O
+with ADP O
+an DET O
+average NOUN O
+of ADP O
+3.8 NUM O
+± SYM O
+1.5 NUM O
+flagella NOUN O
+per ADP O
+cell NOUN O
+( PUNCT O
+averaged VERB O
+across ADP O
+all DET O
+FliK PROPN O
+mutants NOUN O
+) PUNCT O
+compared VERB O
+to ADP O
+3.6 NUM O
+± SYM O
+1.3 NUM O
+flagella NOUN O
+per ADP O
+cell NOUN O
+for ADP O
+the DET O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT O
+wt NOUN B-AC
+) PUNCT O
+, PUNCT O
+except SCONJ O
+for ADP O
+the DET O
+shorter ADJ O
+FliK PROPN O
+variants NOUN O
+FliK310 PROPN O
+and CCONJ O
+FliK377 PROPN O
+( PUNCT O
+Fig PROPN O
+1D NUM O
+, PUNCT O
+S2 NOUN O
+Fig PROPN O
+, PUNCT O
+S1 NOUN O
+Data PROPN O
+) PUNCT O
+. PUNCT O
+
+As SCONJ O
+shown VERB O
+in ADP O
+Fig NOUN O
+1B NUM O
+, PUNCT O
+the DET O
+structure NOUN O
+of ADP O
+CSL PROPN B-AC
+consists VERB O
+of ADP O
+three NUM O
+domains NOUN O
+: PUNCT O
+NTD PROPN B-AC
+( PUNCT O
+N NOUN B-LF
+- NOUN I-LF
+terminal NOUN I-LF
+domain NOUN I-LF
+) PUNCT O
+, PUNCT O
+BTD PROPN B-AC
+( PUNCT O
+β NOUN B-LF
+- NOUN I-LF
+trefoil NOUN I-LF
+domain NOUN I-LF
+) PUNCT O
+, PUNCT O
+and CCONJ O
+CTD NOUN B-AC
+( PUNCT O
+C NOUN B-LF
+- NOUN I-LF
+terminal NOUN I-LF
+domain NOUN I-LF
+) PUNCT O
+[ PUNCT O
+11 NUM O
+] PUNCT O
+. PUNCT O
+
+For ADP O
+continuous ADJ O
+measurements NOUN O
+of ADP O
+Bax PROPN O
+insertion NOUN O
+in ADP O
+OMVs NOUN B-AC
+, PUNCT O
+we PRON O
+adapted VERB O
+a DET O
+fluorometric ADJ O
+method NOUN O
+[ X O
+26 NUM O
+] X O
+that PRON O
+takes VERB O
+advantage NOUN O
+of ADP O
+the DET O
+increased VERB O
+fluorescence NOUN O
+of ADP O
+Bax PROPN O
+labeled VERB O
+with ADP O
+NBD NOUN B-AC
+[ X O
+N NOUN B-LF
+, PUNCT I-LF
+N′-dimethyl NOUN I-LF
+- PUNCT I-LF
+N-(iodoacetyl)-N′-(7 NOUN I-LF
+- PUNCT I-LF
+nitrobenz-2 NOUN I-LF
+- PUNCT I-LF
+oxa-1,3 NOUN I-LF
+- PUNCT I-LF
+diazol-4yl)ethylenediamine NOUN I-LF
+] X O
+that PRON O
+occurs VERB O
+upon SCONJ O
+membrane NOUN O
+insertion NOUN O
+. PUNCT O
+
+Another DET O
+limitation NOUN O
+is AUX O
+that SCONJ O
+the DET O
+Child PROPN B-LF
+Feeding PROPN I-LF
+Questionnaire PROPN I-LF
+for ADP I-LF
+adolescents NOUN I-LF
+( PUNCT O
+CFQ PROPN B-AC
+- PUNCT B-AC
+A PROPN B-AC
+) PUNCT O
+was AUX O
+only ADV O
+translated VERB O
+into ADP O
+German ADJ O
+language NOUN O
+for ADP O
+this DET O
+study NOUN O
+. PUNCT O
+
+HW PROPN B-AC
+, PUNCT O
+health NOUN B-LF
+warning NOUN I-LF
+; PUNCT O
+NFt PROPN B-AC
+, PUNCT O
+Nutrition PROPN B-LF
+Facts PROPN I-LF
+table NOUN I-LF
+; PUNCT O
+NS PROPN B-AC
+, PUNCT O
+nutri NOUN B-LF
+- PUNCT I-LF
+score NOUN I-LF
+; PUNCT O
+NW PROPN B-AC
+, PUNCT O
+nutrient NOUN B-LF
+warning NOUN I-LF
+; PUNCT O
+RCT PROPN B-AC
+, PUNCT O
+randomised ADJ B-LF
+controlled ADJ I-LF
+trial NOUN I-LF
+; PUNCT O
+TLS PROPN B-AC
+, PUNCT O
+traffic NOUN B-LF
+light NOUN I-LF
+labelling NOUN I-LF
+system NOUN I-LF
+. PUNCT O
+
+Most ADV O
+often ADV O
+, PUNCT O
+studies NOUN O
+in ADP O
+this DET O
+area NOUN O
+focus VERB O
+on ADP O
+the DET O
+effects NOUN O
+of ADP O
+OMT PROPN B-AC
+on ADP O
+patients NOUN O
+suffering VERB O
+from ADP O
+COPD PROPN B-AC
+( PUNCT O
+Chronic ADJ B-LF
+Obstructive ADJ I-LF
+Pulmonary PROPN I-LF
+Disease PROPN I-LF
+) PUNCT O
+[ PUNCT O
+1,4–6 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+proteases NOUN O
+( PUNCT O
+secretases NOUN O
+) PUNCT O
+that PRON O
+cleave VERB O
+amyloid NOUN B-LF
+- PUNCT I-LF
+β NOUN I-LF
+( PUNCT O
+Aβ NOUN B-AC
+) PUNCT O
+peptide NOUN O
+from ADP O
+the DET O
+amyloid NOUN B-LF
+precursor NOUN I-LF
+protein NOUN I-LF
+( PUNCT O
+APP NOUN B-AC
+) PUNCT O
+have AUX O
+been AUX O
+the DET O
+focus NOUN O
+of ADP O
+considerable ADJ O
+investigation NOUN O
+in ADP O
+the DET O
+development NOUN O
+of ADP O
+treatments NOUN O
+for ADP O
+Alzheimer PROPN O
+disease NOUN O
+. PUNCT O
+
+Additionally ADV O
+, PUNCT O
+we PRON O
+generated VERB O
+Girdin PROPN B-AC
+knockout NOUN O
+cells NOUN O
+by ADP O
+clustered VERB B-LF
+regularly ADV I-LF
+interspaced VERB I-LF
+short ADJ I-LF
+palindromic ADJ I-LF
+repeat NOUN I-LF
+/ SYM I-LF
+CRISPR NOUN I-LF
+- PUNCT I-LF
+associated VERB I-LF
+9 NUM I-LF
+( PUNCT O
+CRISPR NOUN B-AC
+/ SYM B-AC
+Cas9)-mediated NOUN O
+genome NOUN O
+editing NOUN O
+( PUNCT O
+S1D PROPN O
+– SYM O
+S1F PROPN O
+Fig PROPN O
+) PUNCT O
+. PUNCT O
+
+1 NUM O
+N NOUN O
+/ SYM O
+A NOUN O
+, PUNCT O
+not PART O
+applicable ADJ O
+; PUNCT O
+NG PROPN B-AC
+, PUNCT O
+naso ADJ O
+- NOUN O
+gastric ADJ O
+; PUNCT O
+NJ PROPN B-AC
+, PUNCT O
+naso ADJ O
+- NOUN O
+jejeunal NOUN O
+; PUNCT O
+NNS PROPN B-AC
+, PUNCT O
+no DET O
+nutrition NOUN O
+support NOUN O
+; PUNCT O
+PAB PROPN O
+, PUNCT O
+prophylactic ADJ O
+anti NOUN O
+- NOUN O
+biotics NOUN O
+; PUNCT O
+SAP PROPN O
+, PUNCT O
+severe ADJ O
+acute ADJ O
+pancreatitis NOUN O
+; PUNCT O
+TPN PROPN B-AC
+, PUNCT O
+total ADJ B-LF
+parenteral ADJ I-LF
+nutrition NOUN I-LF
+. PUNCT O
+
+Abbreviation NOUN O
+: PUNCT O
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+
+Acetyl NOUN O
+- PUNCT O
+CoA PROPN O
+, PUNCT O
+acetyl NOUN O
+coenzyme NOUN O
+A NOUN O
+; PUNCT O
+LOS PROPN B-AC
+, PUNCT O
+lipooligosaccharide NOUN B-LF
+; PUNCT O
+OAA PROPN B-AC
+, PUNCT O
+oxaloacetate NOUN B-LF
+; PUNCT O
+PEP PROPN B-AC
+, PUNCT O
+phosphoenolpyruvic NOUN B-LF
+acid NOUN I-LF
+; PUNCT O
+PPP PROPN B-AC
+, PUNCT O
+pentose NOUN B-LF
+phosphate NOUN I-LF
+pathway NOUN I-LF
+. PUNCT O
+
+RTL PROPN B-AC
+was AUX O
+measured VERB O
+by ADP O
+monochrome NOUN B-LF
+multiplex NOUN I-LF
+quantitative ADJ I-LF
+polymerase NOUN I-LF
+chain NOUN I-LF
+reaction NOUN I-LF
+( PUNCT O
+MMQPCR PROPN B-AC
+) PUNCT O
+[ X O
+24 NUM O
+] X O
+using VERB O
+a DET O
+non ADJ O
+- PUNCT O
+homologous ADJ O
+primer NOUN O
+set VERB O
+for ADP O
+the DET O
+telomere NOUN O
+repeats NOUN O
+and CCONJ O
+a DET O
+GC NOUN O
+- PUNCT O
+clamp NOUN O
+primer NOUN O
+set VERB O
+for ADP O
+the DET O
+single ADJ B-LF
+copy NOUN I-LF
+gene NOUN I-LF
+( PUNCT O
+SCG PROPN B-AC
+) PUNCT O
+albumin NOUN O
+. PUNCT O
+
+We PRON O
+used VERB O
+principal ADJ B-LF
+component NOUN I-LF
+analysis NOUN I-LF
+( PUNCT O
+PCA NOUN B-AC
+) PUNCT O
+to PART O
+cluster VERB O
+animals NOUN O
+based VERB O
+on ADP O
+protein NOUN O
+expression NOUN O
+profiles NOUN O
+and CCONJ O
+to PART O
+identify VERB O
+key ADJ O
+proteins NOUN O
+driving VERB O
+this DET O
+clustering NOUN O
+. PUNCT O
+
+Guided VERB O
+by ADP O
+EUCAST PROPN B-AC
+, PUNCT O
+isolates NOUN O
+showing VERB O
+reduced VERB O
+susceptibility NOUN O
+to ADP O
+cefoxitin NOUN O
+( PUNCT O
+MIC NOUN B-AC
+> NUM O
+8 NUM O
+μg NOUN O
+/ X O
+ml NOUN O
+) PUNCT O
+were AUX O
+identified VERB O
+as ADP O
+a DET O
+potential ADJ O
+AmpC PROPN B-LF
+beta NOUN I-LF
+- PUNCT I-LF
+lactamase NOUN I-LF
+producer NOUN O
+. PUNCT O
+
+Among ADP O
+the DET O
+factors NOUN O
+implicated VERB O
+in ADP O
+the DET O
+development NOUN O
+of ADP O
+a DET O
+reactive ADJ O
+stroma NOUN O
+, PUNCT O
+in ADP O
+particular ADJ O
+the DET O
+recruitment NOUN O
+and CCONJ O
+phenotypic ADJ O
+character NOUN O
+of ADP O
+CAFs PROPN B-AC
+, PUNCT O
+are AUX O
+members NOUN O
+of ADP O
+the DET O
+transforming VERB O
+growth NOUN O
+factor NOUN O
+- PUNCT O
+β NOUN O
+and CCONJ O
+the DET O
+platelet NOUN B-LF
+- PUNCT I-LF
+derived VERB I-LF
+growth NOUN I-LF
+factor NOUN I-LF
+( PUNCT O
+PDGF PROPN B-AC
+) PUNCT O
+families NOUN O
+[ X O
+4,6,12 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+objectives NOUN O
+of ADP O
+the DET O
+current ADJ O
+crossover NOUN O
+study NOUN O
+of ADP O
+subjects NOUN O
+with ADP O
+MetS PROPN B-AC
+were AUX O
+to ADP O
+determine VERB O
+how SCONJ O
+an DET O
+AX- PROPN B-AC
+and CCONJ O
+RS PROPN B-AC
+- PUNCT O
+enriched VERB O
+diet NOUN O
+, PUNCT O
+hereafter ADV O
+referred VERB O
+to ADP O
+as ADP O
+a DET O
+healthy ADJ B-LF
+- PUNCT I-LF
+carbohydrate NOUN I-LF
+diet NOUN I-LF
+( PUNCT O
+HCD PROPN B-AC
+) PUNCT O
+, PUNCT O
+alters VERB O
+the DET O
+microbiome NOUN O
+and CCONJ O
+SCFA PROPN O
+concentrations NOUN O
+in ADP O
+faeces NOUN O
+compared VERB O
+with ADP O
+a DET O
+low ADJ O
+- PUNCT O
+fibre NOUN O
+Western ADJ B-LF
+- PUNCT I-LF
+style NOUN I-LF
+diet NOUN I-LF
+( PUNCT O
+WSD PROPN B-AC
+) PUNCT O
+. PUNCT O
+We PRON O
+hypothesised VERB O
+that SCONJ O
+AX PROPN B-AC
+and CCONJ O
+RS PROPN B-AC
+would AUX O
+beneficially ADV O
+change VERB O
+the DET O
+intestinal ADJ O
+microbiota NOUN O
+and CCONJ O
+enhance VERB O
+colonic ADJ O
+SCFA PROPN O
+production NOUN O
+in ADP O
+general ADJ O
+and CCONJ O
+butyrate VERB O
+in ADP O
+particular ADJ O
+compared VERB O
+with ADP O
+the DET O
+WSD PROPN B-AC
+. PUNCT O
+
+Acid NOUN B-LF
+soluble ADJ I-LF
+matrix NOUN I-LF
+( PUNCT O
+ASM PROPN B-AC
+) PUNCT O
+and CCONJ O
+acid NOUN B-LF
+insoluble ADJ I-LF
+matrix NOUN I-LF
+( PUNCT O
+AIM PROPN B-AC
+) PUNCT O
+fractions NOUN O
+of ADP O
+the DET O
+skeleton NOUN O
+stained VERB O
+by ADP O
+silver NOUN O
+staining NOUN O
+. PUNCT O
+
+This DET O
+problem NOUN O
+is AUX O
+particularly ADV O
+acute ADJ O
+in ADP O
+sub ADJ B-LF
+- ADJ I-LF
+Saharan PROPN I-LF
+Africa PROPN I-LF
+( PUNCT O
+SSA PROPN B-AC
+) PUNCT O
+, PUNCT O
+where SCONJ O
+most ADJ O
+of ADP O
+the DET O
+world NOUN O
+’s PART O
+HIV PROPN O
+– PUNCT O
+positive ADJ O
+women NOUN O
+live VERB O
+[ X O
+7 NUM O
+] PUNCT O
+and CCONJ O
+where SCONJ O
+GBV PROPN B-AC
+prevalence NOUN O
+is AUX O
+highest ADJ O
+[ X O
+8 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+program NOUN O
+, PUNCT O
+which PRON O
+was AUX O
+financed VERB O
+by ADP O
+anticipated ADJ O
+carbon NOUN O
+credits NOUN O
+[ PUNCT O
+25 NUM O
+] PUNCT O
+, PUNCT O
+was AUX O
+implemented VERB O
+by ADP O
+the DET O
+UK PROPN O
+- PUNCT O
+based VERB O
+social ADJ O
+enterprise NOUN O
+DelAgua PROPN O
+Health PROPN O
+in ADP O
+collaboration NOUN O
+with ADP O
+the DET O
+Rwanda PROPN O
+Ministry PROPN B-LF
+of ADP I-LF
+Health PROPN I-LF
+( PUNCT O
+MOH PROPN B-AC
+) PUNCT O
+and CCONJ O
+targeted VERB O
+households NOUN O
+in ADP O
+Ubudehe PROPN O
+categories NOUN O
+1 NUM O
+and CCONJ O
+2 NUM O
+— PUNCT O
+roughly ADV O
+the DET O
+government NOUN O
+- PUNCT O
+designated VERB O
+poorest ADJ O
+25 NUM O
+% NOUN O
+of ADP O
+households NOUN O
+in ADP O
+the DET O
+province NOUN O
+[ PUNCT O
+26 NUM O
+] PUNCT O
+. PUNCT O
+
+Gestational ADJ B-LF
+diabetes NOUN I-LF
+mellitus NOUN I-LF
+( PUNCT O
+GDM PROPN B-AC
+) PUNCT O
+is AUX O
+defined VERB O
+as ADP O
+glucose NOUN O
+intolerance NOUN O
+that PRON O
+begins VERB O
+or CCONJ O
+is AUX O
+first ADV O
+recognized VERB O
+during ADP O
+pregnancy NOUN O
+. PUNCT O
+
+CLR PROPN B-AC
+, PUNCT O
+composite ADJ B-LF
+likelihood NOUN I-LF
+ratio NOUN I-LF
+; PUNCT O
+CRE PROPN B-AC
+, PUNCT O
+cis ADJ B-LF
+- PUNCT I-LF
+regulatory ADJ I-LF
+element NOUN I-LF
+; PUNCT O
+SNP PROPN O
+, PUNCT O
+single ADJ O
+- PUNCT O
+nucleotide NOUN O
+polymorphism NOUN O
+
+HLA PROPN O
+- NOUN O
+DR1 PROPN B-AC
+( PUNCT O
+DRB1 NOUN B-LF
+* NOUN I-LF
+0101 NOUN I-LF
+) PUNCT O
+binding VERB O
+epitopes NOUN O
+were AUX O
+predicted VERB O
+using VERB O
+the DET O
+genomic ADJ O
+sequences NOUN O
+of ADP O
+vaccinia NOUN O
+virus NOUN O
+strain NOUN O
+MVA PROPN B-AC
+[ X O
+39 NUM O
+] PUNCT O
+. PUNCT O
+
+As ADP O
+an DET O
+endogenously ADV O
+occurring VERB O
+population NOUN O
+of ADP O
+NPs NOUN B-AC
+, PUNCT O
+human ADJ B-LF
+central ADJ I-LF
+nervous ADJ I-LF
+system NOUN I-LF
+stem NOUN I-LF
+cells NOUN I-LF
+grown VERB I-LF
+as ADP I-LF
+neurospheres NOUN I-LF
+( PUNCT O
+hCNS NOUN B-AC
+- PUNCT B-AC
+SCns NOUN B-AC
+) PUNCT O
+were AUX O
+utilized VERB O
+as ADP O
+a DET O
+natural ADJ O
+benchmark NOUN O
+for ADP O
+derived VERB O
+NPs NOUN B-AC
+. PUNCT O
+We PRON O
+developed VERB O
+an DET O
+approach NOUN O
+called VERB O
+REAP PROPN B-AC
+( PUNCT O
+Regression NOUN B-LF
+- PUNCT I-LF
+based VERB I-LF
+Exon PROPN I-LF
+Array PROPN I-LF
+Protocol PROPN I-LF
+) PUNCT O
+, PUNCT O
+which PRON O
+is AUX O
+based VERB O
+on ADP O
+robust ADJ O
+regression NOUN O
+that PRON O
+analyzed VERB O
+signal NOUN O
+estimates NOUN O
+from ADP O
+Affymetrix PROPN O
+exon NOUN O
+array NOUN O
+data NOUN O
+to PART O
+identify VERB O
+AS NOUN B-AC
+exons NOUN O
+. PUNCT O
+
+Head NOUN B-LF
+and CCONJ I-LF
+neck NOUN I-LF
+squamous ADJ I-LF
+cell NOUN I-LF
+carcinoma NOUN I-LF
+( PUNCT O
+HNSCC PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+global ADJ O
+disease NOUN O
+and CCONJ O
+mortality NOUN O
+burden NOUN O
+, PUNCT O
+necessitating VERB O
+the DET O
+elucidation NOUN O
+of ADP O
+its PRON O
+molecular ADJ O
+progression NOUN O
+for ADP O
+effective ADJ O
+disease NOUN O
+management NOUN O
+. PUNCT O
+
+Activation NOUN O
+of ADP O
+the DET O
+AMP NOUN B-LF
+- PUNCT I-LF
+activated VERB I-LF
+protein NOUN I-LF
+kinase NOUN I-LF
+( PUNCT O
+AMPK PROPN B-AC
+) PUNCT O
+is AUX O
+an DET O
+attractive ADJ O
+approach NOUN O
+for ADP O
+the DET O
+treatment NOUN O
+of ADP O
+type NOUN O
+2 NUM O
+diabetes NOUN O
+. PUNCT O
+
+How SCONJ O
+naturalistic ADJ O
+vibrations NOUN O
+, PUNCT O
+and CCONJ O
+by ADP O
+extension NOUN O
+texture NOUN O
+, PUNCT O
+are AUX O
+encoded VERB O
+in ADP O
+the DET O
+responses NOUN O
+of ADP O
+neurons NOUN O
+in ADP O
+primary ADJ B-LF
+somatosensory NOUN I-LF
+cortex NOUN I-LF
+( PUNCT O
+S1 NOUN B-AC
+) PUNCT O
+is AUX O
+unknown ADJ O
+. PUNCT O
+
+COPD PROPN B-AC
+: PUNCT O
+Chronic ADJ B-LF
+Obstructive ADJ I-LF
+Pulmonary ADJ I-LF
+Disease NOUN I-LF
+. PUNCT O
+
+OMT PROPN B-AC
+— PUNCT O
+Osteopathic ADJ O
+Manual PROPN O
+Therapy NOUN O
+; PUNCT O
+STT PROPN B-AC
+— PUNCT O
+soft ADJ B-LF
+tissue NOUN I-LF
+therapy NOUN I-LF
+; PUNCT O
+FVC PROPN B-AC
+— PUNCT O
+Forced VERB B-LF
+Vital ADJ I-LF
+Capacity PROPN I-LF
+; PUNCT O
+FEV1 PROPN B-AC
+— PUNCT O
+Forced VERB B-LF
+Expiratory NOUN I-LF
+Volume NOUN I-LF
+in ADP I-LF
+1 NUM I-LF
+second NOUN I-LF
+; PUNCT O
+PEF PROPN B-AC
+— PUNCT O
+Peak NOUN B-LF
+Expiratory NOUN I-LF
+Flow NOUN I-LF
+
+Abbreviations NOUN O
+: PUNCT O
+sec PROPN O
+. PUNCT O
+, PUNCT O
+secondary ADJ O
+; PUNCT O
+TBI PROPN B-AC
+, PUNCT O
+traumatic ADJ B-LF
+brain NOUN I-LF
+injury NOUN I-LF
+. PUNCT O
+
+Cells NOUN O
+were AUX O
+sorted VERB O
+by ADP O
+FACS PROPN O
+Aria PROPN O
+III NUM O
+Flow PROPN O
+Sorter PROPN O
+in ADP O
+CMBI PROPN O
+high ADJ O
+throughput NOUN O
+single ADJ O
+- PUNCT O
+cell NOUN O
+analysis NOUN O
+facility NOUN O
+( PUNCT O
+HTSCAF PROPN O
+) PUNCT O
+for ADP O
+yellow ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+YFP PROPN B-AC
+) PUNCT O
+expression NOUN O
+. PUNCT O
+
+Infections NOUN O
+with ADP O
+lymphocytic ADJ B-LF
+choriomeningitis NOUN I-LF
+virus NOUN I-LF
+( PUNCT O
+LCMV PROPN B-AC
+) PUNCT O
+provide VERB O
+potent ADJ O
+stimuli NOUN O
+for ADP O
+Th1 NOUN O
+- PUNCT O
+cell NOUN O
+polarization NOUN O
+[ PUNCT O
+12 NUM O
+] PUNCT O
+. PUNCT O
+
+CES PROPN B-AC
+, PUNCT O
+chromatin NOUN B-LF
+entry NOUN I-LF
+site NOUN I-LF
+; PUNCT O
+MRE PROPN B-AC
+, PUNCT O
+MSL PROPN B-LF
+recognition NOUN I-LF
+element NOUN I-LF
+; PUNCT O
+MSL PROPN B-AC
+, PUNCT O
+male NOUN B-LF
+- PUNCT I-LF
+specific ADJ I-LF
+lethal ADJ I-LF
+; PUNCT O
+pion NOUN B-AC
+- PUNCT B-AC
+X NOUN B-AC
+site NOUN B-AC
+, PUNCT O
+pioneering VERB B-LF
+site NOUN I-LF
+on ADP I-LF
+the DET I-LF
+X. PUNCT I-LF
+
+The DET O
+increased VERB O
+global ADJ O
+incidence NOUN O
+and CCONJ O
+prevalence NOUN O
+of ADP O
+diabetes NOUN O
+, PUNCT O
+hypertension NOUN O
+, PUNCT O
+obesity NOUN O
+and CCONJ O
+other ADJ O
+risk NOUN O
+factors NOUN O
+for ADP O
+kidney NOUN O
+disease NOUN O
+is AUX O
+associated VERB O
+with ADP O
+an DET O
+increased VERB O
+incidence NOUN O
+of ADP O
+end NOUN B-LF
+- ADJ I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD).[1 NOUN B-AC
+] PUNCT O
+The DET O
+golden ADJ O
+standard ADJ O
+treatment NOUN O
+for ADP O
+patients NOUN O
+with ADP O
+ESRD PROPN B-AC
+is AUX O
+kidney NOUN O
+transplantation NOUN O
+, PUNCT O
+but CCONJ O
+unfortunately ADV O
+, PUNCT O
+this DET O
+field NOUN O
+is AUX O
+still ADV O
+suffering VERB O
+from ADP O
+the DET O
+lack NOUN O
+of ADP O
+donor NOUN O
+organs.[2 NOUN O
+] PUNCT O
+Luckily ADV O
+, PUNCT O
+during ADP O
+the DET O
+last ADJ O
+decades NOUN O
+, PUNCT O
+live ADJ O
+kidney NOUN O
+donation NOUN O
+has AUX O
+proven VERB O
+to ADP O
+successfully ADV O
+expand VERB O
+the DET O
+donor NOUN O
+pool NOUN O
+; PUNCT O
+unfortunately ADV O
+, PUNCT O
+it PRON O
+still ADV O
+can AUX O
+not PART O
+meet VERB O
+the DET O
+demand NOUN O
+for ADP O
+donor NOUN O
+kidneys.[2 PUNCT O
+] PUNCT O
+This PRON O
+, PUNCT O
+together ADV O
+with ADP O
+the DET O
+excellent ADJ O
+results NOUN O
+of ADP O
+live ADJ O
+donor NOUN O
+kidney NOUN O
+transplantation NOUN O
+, PUNCT O
+leads VERB O
+to ADP O
+an DET O
+increase NOUN O
+in ADP O
+the DET O
+acceptance NOUN O
+of ADP O
+live ADJ O
+donors NOUN O
+with ADP O
+so ADV O
+called VERB O
+‘ PUNCT O
+extended ADJ O
+donor NOUN O
+criteria NOUN O
+’ PUNCT O
+, PUNCT O
+i.e. X O
+, PUNCT O
+older ADJ O
+donors NOUN O
+, PUNCT O
+overweight ADJ O
+/ SYM O
+obese ADJ O
+donors NOUN O
+, PUNCT O
+donor NOUN O
+kidneys NOUN O
+with ADP O
+vascular ADJ O
+multiplicity NOUN O
+, PUNCT O
+donors NOUN O
+with ADP O
+comorbidities NOUN O
+, PUNCT O
+women NOUN O
+of ADP O
+childbearing NOUN O
+age NOUN O
+, PUNCT O
+and CCONJ O
+even ADV O
+minors NOUN O
+as ADP O
+potential ADJ O
+donors.[3 NOUN O
+] PUNCT O
+In ADP O
+general ADJ O
+, PUNCT O
+live ADJ O
+kidney NOUN O
+donors NOUN O
+are AUX O
+in ADP O
+good ADJ O
+health NOUN O
+, PUNCT O
+and CCONJ O
+therefore ADV O
+it PRON O
+is AUX O
+critical ADJ O
+that SCONJ O
+these DET O
+potential ADJ O
+donors NOUN O
+do AUX O
+not PART O
+become VERB O
+kidney NOUN O
+patients NOUN O
+themselves PRON O
+. PUNCT O
+
+In ADP O
+addition NOUN O
+, PUNCT O
+down ADJ O
+- NOUN O
+regulation NOUN O
+of ADP O
+mitochondrial ADJ O
+uncoupling NOUN B-LF
+protein NOUN I-LF
+2 NUM I-LF
+( PUNCT O
+Ucp2 NOUN B-AC
+) PUNCT O
+was AUX O
+observed VERB O
+in ADP O
+brown ADJ O
+adipose NOUN O
+in ADP O
+Oct1-/- NOUN O
+mice NOUN O
+( PUNCT O
+S5 PROPN O
+G PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+which PRON O
+may AUX O
+associate VERB O
+with ADP O
+the DET O
+reduced VERB O
+energy NOUN O
+expenditure NOUN O
+. PUNCT O
+
+The DET O
+aim NOUN O
+of ADP O
+this DET O
+study NOUN O
+was AUX O
+to PART O
+validate VERB O
+and CCONJ O
+correlate VERB O
+the DET O
+performance NOUN O
+of ADP O
+cobas NOUN O
+HCV PROPN B-AC
+with ADP O
+the DET O
+established VERB O
+CAP PROPN B-AC
+/ SYM B-AC
+CTM PROPN B-AC
+in ADP O
+a DET O
+large ADJ O
+patient NOUN O
+population NOUN O
+with ADP O
+HCV PROPN B-AC
+genotypes NOUN B-LF
+( PUNCT O
+GT PROPN B-AC
+) PUNCT O
+1 NUM O
+and CCONJ O
+3 NUM O
+treated VERB O
+with ADP O
+DAAs PROPN B-AC
+. PUNCT O
+
+The DET O
+pyloric ADJ O
+rhythm NOUN O
+is AUX O
+triphasic ADJ O
+and CCONJ O
+consists VERB O
+of ADP O
+the DET O
+alternating VERB O
+activities NOUN O
+of ADP O
+the DET O
+PD PROPN B-AC
+neurons NOUN O
+and CCONJ O
+the DET O
+lateral ADJ B-LF
+pyloric ADJ I-LF
+( PUNCT O
+LP NOUN B-AC
+) PUNCT O
+and CCONJ O
+pyloric ADJ B-LF
+constrictor NOUN I-LF
+( PUNCT O
+PY PROPN B-AC
+) PUNCT O
+neurons NOUN O
+. PUNCT O
+
+Approximately ADV O
+half NOUN O
+of ADP O
+all DET O
+cases NOUN O
+of ADP O
+CKD PROPN B-AC
+in ADP O
+children NOUN O
+in ADP O
+high ADJ O
+income NOUN O
+countries NOUN O
+are AUX O
+due ADJ O
+to ADP O
+congenital ADJ B-LF
+anomalies NOUN I-LF
+of ADP I-LF
+the DET I-LF
+kidney NOUN I-LF
+and CCONJ I-LF
+urinary ADJ I-LF
+tract NOUN I-LF
+( PUNCT O
+CAKUT PROPN B-AC
+) PUNCT O
+[ PUNCT O
+4,5 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+main ADJ O
+purpose NOUN O
+for ADP O
+the DET O
+second ADJ O
+phase NOUN O
+is AUX O
+the DET O
+generation NOUN O
+of ADP O
+the DET O
+approximate ADJ B-LF
+Pareto ADJ I-LF
+- NOUN I-LF
+optimal ADJ I-LF
+solutions NOUN I-LF
+XE NOUN B-AC
+. PUNCT O
+The DET O
+pseudo NOUN O
+- NOUN O
+code NOUN O
+of ADP O
+the DET O
+PLS NOUN B-AC
+is AUX O
+shown VERB O
+in ADP O
+algorithm NOUN O
+2 NUM O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+CI NOUN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+IQR PROPN O
+, PUNCT O
+interquartile ADJ O
+range NOUN O
+; PUNCT O
+SD NOUN O
+, PUNCT O
+standard ADJ O
+deviation NOUN O
+; PUNCT O
+SE NOUN B-AC
+, PUNCT O
+sleep NOUN B-LF
+efficiency NOUN I-LF
+; PUNCT O
+SOL NOUN B-AC
+, PUNCT O
+sleep NOUN B-LF
+onset NOUN I-LF
+latency NOUN I-LF
+; PUNCT O
+TIB NOUN B-AC
+, PUNCT O
+time NOUN B-LF
+in ADP I-LF
+bed NOUN I-LF
+; PUNCT O
+TST NOUN B-AC
+, PUNCT O
+total ADJ B-LF
+sleep NOUN I-LF
+time NOUN I-LF
+; PUNCT O
+WASO NOUN B-AC
+, PUNCT O
+wake VERB B-LF
+after ADP I-LF
+sleep NOUN I-LF
+onset NOUN I-LF
+. PUNCT O
+
+The DET O
+data NOUN O
+underlying VERB O
+( PUNCT O
+G NOUN O
+, PUNCT O
+H NOUN O
+) PUNCT O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S7 PROPN O
+Source PROPN O
+Data PROPN O
+. PUNCT O
+aPS PROPN B-AC
+, PUNCT O
+anterior ADJ B-LF
+primitive ADJ I-LF
+streak NOUN I-LF
+; PUNCT O
+DE PROPN O
+, PUNCT O
+definitive ADJ O
+endoderm NOUN O
+; PUNCT O
+EB NOUN B-AC
+, PUNCT O
+early ADJ B-LF
+bud NOUN I-LF
+; PUNCT O
+LPM PROPN O
+/ SYM O
+Ex PROPN O
+- PUNCT O
+meso NOUN O
+, PUNCT O
+lateral ADJ O
+plate NOUN O
+mesoderm NOUN O
+and CCONJ O
+extraembryonic ADJ O
+mesoderm NOUN O
+, PUNCT O
+mesenchyme NOUN O
+; PUNCT O
+LS PROPN O
+, PUNCT O
+late ADJ O
+streak NOUN O
+; PUNCT O
+MS PROPN O
+, PUNCT O
+mid NOUN O
+- PUNCT O
+streak NOUN O
+; PUNCT O
+Nascent PROPN O
+meso NOUN O
+, PUNCT O
+nascent ADJ O
+mesoderm NOUN O
+; PUNCT O
+OB PROPN B-AC
+, PUNCT O
+no DET B-LF
+bud NOUN I-LF
+; PUNCT O
+PGC PROPN O
+, PUNCT O
+primordial ADJ O
+germs NOUN O
+cells NOUN O
+; PUNCT O
+PS PROPN O
+, PUNCT O
+primitive ADJ O
+streak NOUN O
+; PUNCT O
+scRNA NOUN O
+- PUNCT O
+seq NOUN O
+, PUNCT O
+single ADJ O
+- PUNCT O
+cell NOUN O
+RNA NOUN O
+sequencing NOUN O
+; PUNCT O
+UMAP PROPN B-AC
+, PUNCT O
+Uniform PROPN B-LF
+Manifold PROPN I-LF
+Approximation PROPN I-LF
+Projection PROPN I-LF
+. PUNCT O
+
+The DET O
+increased VERB O
+risk NOUN O
+of ADP O
+CVD NOUN B-AC
+in ADP O
+cancer NOUN O
+survivors NOUN O
+is AUX O
+in ADP O
+part NOUN O
+associated VERB O
+with ADP O
+cancer NOUN B-LF
+therapy NOUN I-LF
+– PUNCT I-LF
+related VERB I-LF
+cardiac ADJ I-LF
+dysfunction NOUN I-LF
+( PUNCT O
+CTRCD NOUN B-AC
+) PUNCT O
+[ PUNCT O
+4 NUM O
+] PUNCT O
+, PUNCT O
+including VERB O
+radiotherapy NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+, PUNCT O
+cytotoxic ADJ O
+chemotherapy NOUN O
+[ PUNCT O
+6 NUM O
+] PUNCT O
+, PUNCT O
+targeted VERB O
+therapies NOUN O
+[ PUNCT O
+7–9 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+immunotherapy NOUN O
+[ PUNCT O
+10–12 NUM O
+] PUNCT O
+. PUNCT O
+
+Co NOUN O
+- PUNCT O
+administration NOUN O
+of ADP O
+efavirenz PROPN O
+with ADP O
+nucleoside NOUN B-LF
+reverse ADJ I-LF
+transcriptase NOUN I-LF
+inhibitors NOUN I-LF
+( PUNCT O
+NRTI PROPN B-AC
+) PUNCT O
+, PUNCT O
+namely ADV O
+tenofovir NOUN O
+disoproxil NOUN O
+fumarate NOUN O
+and CCONJ O
+lamivudine NOUN O
+, PUNCT O
+or CCONJ O
+alternatively ADV O
+, PUNCT O
+emtricitabine NOUN O
+, PUNCT O
+is VERB O
+currently ADV O
+the DET O
+preferred ADJ O
+first ADJ O
+- PUNCT O
+line NOUN O
+regimen NOUN O
+of ADP O
+combination NOUN B-LF
+antiretroviral ADJ I-LF
+therapy NOUN I-LF
+( PUNCT O
+cART PROPN B-AC
+) PUNCT O
+. PUNCT O
+Although SCONJ O
+efavirenz PROPN O
+has AUX O
+been AUX O
+used VERB O
+in ADP O
+clinical ADJ O
+practice NOUN O
+for ADP O
+almost ADV O
+two NUM O
+decades NOUN O
+, PUNCT O
+there PRON O
+is VERB O
+still ADV O
+a DET O
+great ADJ O
+need NOUN O
+for ADP O
+deeper ADJ O
+knowledge NOUN O
+regarding VERB O
+the DET O
+safety NOUN O
+of ADP O
+efavirenz PROPN O
+- PUNCT O
+containing VERB O
+treatment NOUN O
+regimens NOUN O
+[ PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+A X O
+, PUNCT O
+B NOUN O
+; PUNCT O
+To PART O
+assess VERB O
+differentiation NOUN O
+of ADP O
+OPCs NOUN B-AC
+derived VERB O
+from ADP O
+neonatal ADJ O
+rat NOUN O
+pups NOUN O
+into ADP O
+oligodendrocytes NOUN O
+, PUNCT O
+cells NOUN O
+were AUX O
+immunolabelled VERB O
+with ADP O
+antibodies NOUN O
+against ADP O
+O4 PROPN O
+( PUNCT O
+red ADJ O
+) PUNCT O
+and CCONJ O
+myelin NOUN B-LF
+basic ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+MBP NOUN B-AC
+, PUNCT O
+green ADJ O
+) PUNCT O
+. PUNCT O
+
+HR NOUN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+CIs NOUN B-AC
+, PUNCT O
+confidential ADJ O
+intervals NOUN O
+; PUNCT O
+ER NOUN B-AC
+, PUNCT O
+estrogen NOUN B-LF
+receptor NOUN I-LF
+; PUNCT O
+PR NOUN B-AC
+, PUNCT O
+progesterone NOUN B-LF
+receptor NOUN I-LF
+; PUNCT O
+HER-2 NOUN O
+, PUNCT O
+human ADJ O
+epidermal ADJ O
+growth NOUN O
+factor NOUN O
+receptor-2 NOUN O
+; PUNCT O
+HG NOUN B-AC
+, PUNCT O
+histologic ADJ B-LF
+grade NOUN I-LF
+; PUNCT O
+LVI PROPN B-AC
+, PUNCT O
+lymph NOUN O
+- PUNCT O
+vascular NOUN O
+invasion NOUN O
+. PUNCT O
+
+6 X O
+. PUNCT O
+Discussion NOUN O
+: PUNCT O
+1 X O
+) PUNCT O
+Line NOUN O
+217 NUM O
+- SYM O
+220 NUM O
+: PUNCT O
+typo NOUN O
+and CCONJ O
+consider VERB O
+use NOUN O
+of ADP O
+standard ADJ O
+reference NOUN O
+for ADP O
+“ PUNCT O
+mean ADJ O
+difference NOUN O
+” PUNCT O
+( PUNCT O
+bias NOUN O
+) PUNCT O
+as ADP O
+the DET O
+quantified VERB O
+degree NOUN O
+of ADP O
+agreement NOUN O
+and CCONJ O
+“ PUNCT O
+limits NOUN B-LF
+of ADP I-LF
+agreement NOUN I-LF
+” PUNCT O
+( PUNCT O
+precision NOUN O
+) PUNCT O
+as ADP O
+SD NOUN B-AC
+and CCONJ O
+the DET O
+95 NUM O
+% NOUN O
+LOAs NOUN B-AC
+. PUNCT O
+2 X O
+) PUNCT O
+Line NOUN O
+240 NUM O
+– PUNCT O
+this PRON O
+statement NOUN O
+re ADP O
+: PUNCT O
+“ PUNCT O
+… PUNCT O
+although SCONJ O
+this PRON O
+was AUX O
+not PART O
+statistically ADV O
+significant ADJ O
+” PUNCT O
+was AUX O
+not PART O
+clear ADJ O
+to ADP O
+me PRON O
+. PUNCT O
+3 X O
+) PUNCT O
+Line NOUN O
+266 NUM O
+- SYM O
+270 NUM O
+: PUNCT O
+recommend VERB O
+using VERB O
+hypothermic ADJ O
+and CCONJ O
+febrile ADJ O
+range NOUN O
+temperatures NOUN O
+. PUNCT O
+
+5HTTLPR PROPN B-AC
+, PUNCT O
+5HTT NOUN B-LF
+- PUNCT I-LF
+linked VERB I-LF
+polymorphic ADJ I-LF
+region NOUN I-LF
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+GDM NOUN B-AC
+, PUNCT O
+gestational ADJ B-LF
+diabetes NOUN I-LF
+mellitus NOUN I-LF
+; PUNCT O
+HbA1c NOUN B-AC
+, PUNCT O
+glycated VERB B-LF
+hemoglobin NOUN I-LF
+. PUNCT O
+
+The DET O
+acute ADJ O
+- NOUN O
+phase NOUN O
+increase NOUN O
+in ADP O
+serum ADJ O
+C NOUN B-LF
+- NOUN I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+( PUNCT O
+CRP NOUN B-AC
+) PUNCT O
+is AUX O
+used VERB O
+to PART O
+diagnose VERB O
+and CCONJ O
+monitor VERB O
+infectious ADJ O
+and CCONJ O
+inflammatory ADJ O
+diseases NOUN O
+. PUNCT O
+
+Previous ADJ O
+work NOUN O
+demonstrated VERB O
+minimal ADJ O
+rates NOUN O
+of ADP O
+inappropriate ADJ O
+PCIs NOUN B-AC
+in ADP O
+patients NOUN O
+being AUX O
+treated VERB O
+for ADP O
+an DET O
+acute ADJ B-LF
+coronary ADJ I-LF
+syndrome NOUN I-LF
+( PUNCT O
+ACS PROPN B-AC
+) PUNCT O
+, PUNCT O
+but CCONJ O
+almost ADV O
+1 NUM O
+in ADP O
+8 NUM O
+procedures NOUN O
+in ADP O
+the DET O
+setting NOUN O
+of ADP O
+stable ADJ O
+coronary ADJ O
+artery NOUN O
+disease NOUN O
+( PUNCT O
+CAD PROPN O
+) PUNCT O
+were AUX O
+inappropriate ADJ O
+and CCONJ O
+nearly ADV O
+1 NUM O
+in ADP O
+6 NUM O
+PCIs NOUN B-AC
+were AUX O
+unmappable ADJ O
+due ADP O
+to ADP O
+missing VERB O
+data NOUN O
+. PUNCT O
+[ X O
+4 NUM O
+] X O
+
+Phloem NOUN O
+differentiation NOUN O
+is AUX O
+regulated VERB O
+by ADP O
+transcription NOUN O
+factors NOUN O
+, PUNCT O
+including VERB O
+ALTERED VERB B-LF
+PHLOEM PROPN I-LF
+DEVELOPMENT NOUN I-LF
+( PUNCT O
+APL PROPN B-AC
+) PUNCT O
+and CCONJ O
+OCTOPUS NOUN B-LF
+( PUNCT O
+OPS NOUN B-AC
+) PUNCT O
+[ PUNCT O
+15,16 NUM O
+] PUNCT O
+. PUNCT O
+
+During ADP O
+the DET O
+consultation NOUN O
+, PUNCT O
+clinical ADJ O
+signs NOUN O
+of ADP O
+a DET O
+relevant ADJ O
+focused VERB O
+examination NOUN O
+were AUX O
+also ADV O
+recorded VERB O
+( PUNCT O
+vital ADJ O
+and CCONJ O
+danger NOUN O
+signs NOUN O
+, PUNCT O
+temperature NOUN O
+, PUNCT O
+respiratory ADJ O
+rate NOUN O
+, PUNCT O
+malnutrition NOUN O
+assessment NOUN O
+, PUNCT O
+etc X O
+. PUNCT O
+) PUNCT O
+along ADP O
+with ADP O
+laboratory NOUN O
+tests NOUN O
+recommended VERB O
+by ADP O
+the DET O
+app NOUN O
+( PUNCT O
+mRDT NOUN B-AC
+, PUNCT O
+C NOUN B-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+[ PUNCT O
+CRP PROPN B-AC
+] PUNCT O
+, PUNCT O
+hemoglobin NOUN O
+, PUNCT O
+urinary ADJ O
+dipstick NOUN O
+, PUNCT O
+etc X O
+. PUNCT O
+) PUNCT O
+. PUNCT O
+
+HFE PROPN O
+wild ADJ B-LF
+type NOUN I-LF
+( PUNCT O
+WT PROPN B-AC
+) PUNCT O
+, PUNCT O
+( PUNCT O
+ii X O
+) PUNCT O
+females NOUN O
+vs. ADP O
+males NOUN O
+. PUNCT O
+
+The DET O
+Kidney PROPN B-LF
+Failure PROPN I-LF
+Risk PROPN I-LF
+Equation PROPN I-LF
+( PUNCT O
+KFRE PROPN B-AC
+) PUNCT O
+uses VERB O
+the DET O
+4 NUM O
+variables NOUN O
+of ADP O
+age NOUN O
+, PUNCT O
+sex NOUN O
+, PUNCT O
+urine NOUN O
+albumin NOUN B-LF
+- PUNCT I-LF
+to PART I-LF
+- PUNCT I-LF
+creatinine NOUN I-LF
+ratio NOUN I-LF
+( PUNCT O
+ACR PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+eGFR PROPN B-AC
+) PUNCT O
+in ADP O
+individuals NOUN O
+with ADP O
+chronic ADJ B-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+CKD PROPN B-AC
+) PUNCT O
+to PART O
+predict VERB O
+the DET O
+risk NOUN O
+of ADP O
+end NOUN B-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD PROPN B-AC
+) PUNCT O
+, PUNCT O
+i.e. X O
+, PUNCT O
+the DET O
+need NOUN O
+for ADP O
+dialysis NOUN O
+or CCONJ O
+a DET O
+kidney NOUN O
+transplant NOUN O
+, PUNCT O
+within ADP O
+2 NUM O
+and CCONJ O
+5 NUM O
+years NOUN O
+. PUNCT O
+
+The DET O
+gene NOUN O
+expression NOUN O
+level NOUN O
+changes NOUN O
+under ADP O
+Zinc NOUN B-LF
+deficiency NOUN I-LF
+( PUNCT O
+ZnD PROPN B-AC
+) PUNCT O
+, PUNCT O
+iron NOUN B-LF
+deficiency NOUN I-LF
+( PUNCT O
+FeD NOUN B-AC
+) PUNCT O
+, PUNCT O
+excess ADJ B-LF
+Zn NOUN I-LF
+( PUNCT O
+ZnE NOUN B-AC
+) PUNCT O
+and CCONJ O
+cadmium NOUN B-LF
+exposure NOUN I-LF
+( PUNCT O
+CdE NOUN B-AC
+) PUNCT O
+compared VERB O
+to ADP O
+the DET O
+normal ADJ O
+condition NOUN O
+were AUX O
+analyzed VERB O
+. PUNCT O
+( PUNCT O
+a X O
+) PUNCT O
+The DET O
+BrGLYI PROPN O
+gene NOUN O
+expression NOUN O
+level NOUN O
+, PUNCT O
+( PUNCT O
+b X O
+) PUNCT O
+The DET O
+BrGLYII PROPN O
+gene NOUN O
+expression NOUN O
+level NOUN O
+. PUNCT O
+
+As ADP O
+an DET O
+orthogonal ADJ O
+unbiased ADJ O
+high ADJ O
+- PUNCT O
+throughput NOUN O
+approach NOUN O
+, PUNCT O
+competitive ADJ O
+Fluorescence PROPN B-LF
+Polarization PROPN I-LF
+( PUNCT O
+FP PROPN B-AC
+) PUNCT O
+method NOUN O
+has AUX O
+also ADV O
+been AUX O
+used VERB O
+to PART O
+monitor VERB O
+the DET O
+interactions NOUN O
+of ADP O
+the DET O
+same ADJ O
+PDZ PROPN B-AC
+domains NOUN O
+with ADP O
+PTEN_11 NOUN O
+( PUNCT O
+Fig PROPN O
+3B NUM O
+) PUNCT O
+. PUNCT O
+For ADP O
+the DET O
+tested VERB O
+PDZ PROPN B-AC
+/ SYM O
+PBM NOUN B-AC
+pairs NOUN O
+, PUNCT O
+the DET O
+apparent ADJ O
+affinities NOUN O
+were AUX O
+obtained VERB O
+by ADP O
+fitting VERB O
+the DET O
+polarization NOUN O
+data NOUN O
+considering VERB O
+a DET O
+competitive ADJ O
+binding VERB O
+model NOUN O
+[ PUNCT O
+42 NUM O
+] PUNCT O
+. PUNCT O
+
+Yunnan PROPN O
+province NOUN O
+itself PRON O
+has VERB O
+a DET O
+large ADJ O
+population NOUN O
+of ADP O
+people NOUN B-LF
+who PRON I-LF
+inject VERB I-LF
+drugs NOUN I-LF
+( PUNCT O
+PWID PROPN B-AC
+) PUNCT O
+[ PUNCT O
+15 NUM O
+, PUNCT O
+16 NUM O
+] PUNCT O
+. PUNCT O
+possibly ADV O
+due ADJ O
+to ADP O
+Yunnan PROPN O
+’s PART O
+position NOUN O
+along ADP O
+key ADJ O
+heroin NOUN O
+trafficking NOUN O
+routes NOUN O
+into ADP O
+China PROPN O
+[ PUNCT O
+17 NUM O
+, PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+ICD PROPN B-AC
+, PUNCT O
+International PROPN B-LF
+Classification PROPN I-LF
+of ADP I-LF
+Diseases PROPN I-LF
+; PUNCT O
+MS PROPN B-AC
+, PUNCT O
+multiple ADJ B-LF
+sclerosis NOUN I-LF
+; PUNCT O
+RR PROPN B-AC
+, PUNCT O
+risk NOUN B-LF
+ratio NOUN I-LF
+. PUNCT O
+
+IR PROPN O
+, PUNCT O
+infrared NOUN O
+; PUNCT O
+RGC PROPN B-AC
+, PUNCT O
+retinal ADJ B-LF
+ganglion NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+V PROPN B-AC
+- PUNCT B-AC
+DSGC PROPN B-AC
+, PUNCT O
+ventral ADJ B-LF
+- PUNCT I-LF
+preferring VERB I-LF
+direction NOUN I-LF
+selective ADJ I-LF
+ganglion NOUN I-LF
+cell NOUN I-LF
+; PUNCT O
+Vm PROPN O
+, PUNCT O
+membrane NOUN O
+potential NOUN O
+; PUNCT O
+VME PROPN B-AC
+, PUNCT O
+visual ADJ B-LF
+motion NOUN I-LF
+experience NOUN I-LF
+; PUNCT O
+YFP PROPN O
+, PUNCT O
+yellow ADJ O
+fluorescent ADJ O
+protein NOUN O
+. PUNCT O
+
+And CCONJ O
+the DET O
+results NOUN O
+of ADP O
+western ADJ O
+blot NOUN O
+showed VERB O
+that SCONJ O
+Klf5 NOUN B-AC
+expression NOUN O
+in ADP O
+ruptured VERB O
+AAA PROPN B-AC
+( PUNCT O
+4 NUM O
+cases NOUN O
+) PUNCT O
+was AUX O
+significantly ADV O
+lower ADJ O
+than ADP O
+that SCONJ O
+in ADP O
+unruptured ADJ O
+AAA PROPN B-AC
+( PUNCT O
+22 NUM O
+cases NOUN O
+) PUNCT O
+, PUNCT O
+even ADV O
+though SCONJ O
+its PRON O
+expression NOUN O
+was AUX O
+higher ADJ O
+than ADP O
+that SCONJ O
+in ADP O
+normal ADJ O
+abdominal ADJ O
+aorta NOUN O
+( PUNCT O
+8 NUM O
+cases NOUN O
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+1A NUM O
+and CCONJ O
+1B NUM O
+) PUNCT O
+. PUNCT O
+Furthermore ADV O
+, PUNCT O
+confocal ADJ O
+microscopy NOUN O
+images NOUN O
+were AUX O
+obtained VERB O
+by ADP O
+immunofluorescence NOUN O
+staining NOUN O
+with ADP O
+VSMC PROPN B-AC
+marker NOUN O
+( PUNCT O
+smooth ADJ B-LF
+muscle NOUN I-LF
+α NOUN I-LF
+- PUNCT I-LF
+actin NOUN I-LF
+, PUNCT O
+SMA PROPN B-AC
+) PUNCT O
+and CCONJ O
+Klf5 NOUN B-AC
+, PUNCT O
+and CCONJ O
+showed VERB O
+that SCONJ O
+Klf5 NOUN B-AC
+was AUX O
+co VERB O
+- PUNCT O
+localized VERB O
+with ADP O
+VSMC PROPN B-AC
+marker NOUN O
+in ADP O
+unruptured ADJ O
+AAA PROPN B-AC
+( PUNCT O
+Fig PROPN O
+1C NUM O
+) PUNCT O
+. PUNCT O
+Moreover ADV O
+, PUNCT O
+Klf5 NOUN B-AC
+- PUNCT O
+positive ADJ O
+VSMCs NOUN B-AC
+were AUX O
+hardly ADV O
+observed VERB O
+in ADP O
+ruptured VERB O
+AAA PROPN B-AC
+, PUNCT O
+while SCONJ O
+the DET O
+percentages NOUN O
+of ADP O
+Klf5 NOUN B-AC
+- PUNCT O
+positive ADJ O
+VSMCs NOUN B-AC
+were AUX O
+significantly ADV O
+higher ADJ O
+in ADP O
+unruptured ADJ O
+AAA PROPN B-AC
+than ADP O
+in ADP O
+the DET O
+normal ADJ O
+aorta NOUN O
+( PUNCT O
+10.3 NUM O
+% NOUN O
+± ADP O
+2.2 NUM O
+% NOUN O
+versus ADP O
+2.4 NUM O
+% NOUN O
+± ADP O
+0.89 NUM O
+% NOUN O
+; NOUN O
+Fig PROPN O
+1C NUM O
+and CCONJ O
+1D NOUN O
+) PUNCT O
+. PUNCT O
+
+Subsequently ADV O
+, PUNCT O
+a DET O
+multivariate ADJ O
+Bayesian ADJ B-LF
+network NOUN I-LF
+( PUNCT O
+BN PROPN B-AC
+, PUNCT O
+using VERB O
+the DET O
+R PROPN O
+package NOUN O
+bnlearn PROPN O
+) PUNCT O
+[ X O
+15 NUM O
+] PUNCT O
+was AUX O
+constructed VERB O
+to PART O
+explore VERB O
+the DET O
+structural ADJ O
+relationships NOUN O
+between ADP O
+variables NOUN O
+; PUNCT O
+BN PROPN B-AC
+analysis NOUN O
+determines VERB O
+an DET O
+optimal ADJ O
+statistical ADJ O
+description NOUN O
+of ADP O
+all DET O
+the DET O
+data NOUN O
+as SCONJ O
+it PRON O
+considers VERB O
+many ADJ O
+possible ADJ O
+model NOUN O
+structures NOUN O
+[ X O
+16 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+connection NOUN O
+between ADP O
+the DET O
+basal ADJ B-LF
+ganglia NOUN I-LF
+( PUNCT O
+BG PROPN B-AC
+) PUNCT O
+and CCONJ O
+one NUM O
+of ADP O
+its PRON O
+major ADJ O
+downstream ADJ O
+targets NOUN O
+, PUNCT O
+the DET O
+thalamus NOUN O
+, PUNCT O
+has AUX O
+received VERB O
+increased VERB O
+attention NOUN O
+recently ADV O
+[ X O
+1 NUM O
+; PUNCT O
+2 NUM O
+; PUNCT O
+3 NUM O
+, PUNCT O
+4 NUM O
+; PUNCT O
+5 NUM O
+] X O
+due ADP O
+to ADP O
+its PRON O
+role NOUN O
+as ADP O
+a DET O
+key ADJ O
+pathway NOUN O
+by ADP O
+which PRON O
+the DET O
+BG PROPN B-AC
+can AUX O
+influence VERB O
+cortical ADJ O
+function NOUN O
+. PUNCT O
+
+Preeclampsia NOUN B-LF
+( PUNCT O
+PE NOUN B-AC
+) PUNCT O
+is AUX O
+the DET O
+most ADV O
+frequently ADV O
+encountered VERB O
+severe ADJ O
+complication NOUN O
+during ADP O
+pregnancy NOUN O
+with ADP O
+a DET O
+clinical ADJ O
+spectrum NOUN O
+ranging VERB O
+from ADP O
+relatively ADV O
+mild ADJ O
+to ADP O
+life NOUN O
+- PUNCT O
+threatening VERB O
+[ PUNCT O
+1 NUM O
+, PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Difference NOUN B-LF
+- PUNCT I-LF
+in ADP I-LF
+- PUNCT I-LF
+differences NOUN I-LF
+estimates NOUN I-LF
+( PUNCT O
+DDEs NOUN B-AC
+) PUNCT O
+of ADP O
+impact NOUN O
+were AUX O
+calculated VERB O
+, PUNCT O
+adjusting VERB O
+for ADP O
+clustering NOUN O
+. PUNCT O
+
+We PRON O
+gathered VERB O
+male NOUN O
+and CCONJ O
+female ADJ O
+RNA NOUN B-LF
+sequencing NOUN I-LF
+( PUNCT O
+RNA NOUN B-AC
+- ADJ B-AC
+seq NOUN B-AC
+) PUNCT O
+data NOUN O
+from ADP O
+D. PROPN O
+melanica PROPN O
+and CCONJ O
+D. PROPN O
+robusta PROPN O
+heads NOUN O
+to PART O
+test VERB O
+whether SCONJ O
+expression NOUN O
+levels NOUN O
+of ADP O
+the DET O
+newly ADV O
+formed VERB O
+neo ADJ O
+- ADJ O
+X ADJ O
+chromosomes NOUN O
+are AUX O
+similar ADJ O
+between ADP O
+males NOUN O
+and CCONJ O
+females NOUN O
+( PUNCT O
+that ADV O
+is AUX O
+, PUNCT O
+whether SCONJ O
+they PRON O
+have AUX O
+evolved VERB O
+dosage NOUN O
+compensation NOUN O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+our PRON O
+initial ADJ O
+analysis NOUN O
+we PRON O
+compared VERB O
+a DET O
+random ADJ B-LF
+forest NOUN I-LF
+( PUNCT O
+RF NOUN B-AC
+) PUNCT O
+, PUNCT O
+support NOUN B-LF
+vector NOUN I-LF
+machine NOUN I-LF
+( PUNCT O
+SVM PROPN B-AC
+) PUNCT O
+, PUNCT O
+logistic ADJ B-LF
+regression NOUN I-LF
+( PUNCT O
+LR NOUN B-AC
+) PUNCT O
+, PUNCT O
+simple ADJ O
+decision NOUN B-LF
+tree NOUN I-LF
+( PUNCT O
+DT NOUN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+artificial ADJ O
+neural ADJ O
+network NOUN O
+( PUNCT O
+ANN PROPN O
+) PUNCT O
+model NOUN O
+on ADP O
+the DET O
+entire ADJ O
+feature NOUN O
+set NOUN O
+. PUNCT O
+
+GS PROPN B-AC
+was AUX O
+pulled VERB O
+down ADP O
+with ADP O
+GST PROPN O
+- PUNCT O
+glycogenin NOUN B-LF
+— PUNCT O
+GST PROPN O
+- PUNCT O
+GN(297–333)—fusion NOUN B-AC
+protein NOUN O
+before ADP O
+and CCONJ O
+after ADP O
+α NOUN O
+- PUNCT O
+amylase NOUN O
+digestion NOUN O
+of ADP O
+glycogen NOUN O
+in ADP O
+skeletal ADJ O
+muscle NOUN O
+extracts NOUN O
+from ADP O
+wild ADJ O
+type NOUN O
+( PUNCT O
+RGL PROPN O
+WT PROPN B-AC
+) PUNCT O
+and CCONJ O
+RGL PROPN B-LF
+knock ADJ I-LF
+- PUNCT I-LF
+in ADP I-LF
+homozygous ADJ O
+( PUNCT O
+RGL PROPN B-AC
+kin NOUN B-AC
+hom NOUN O
+) PUNCT O
+mice NOUN O
+. PUNCT O
+( PUNCT O
+A X O
+) PUNCT O
+GST PROPN O
+- PUNCT O
+GN(297–333 NUM B-AC
+) PUNCT O
+pulls VERB O
+down ADP O
+almost ADV O
+all PRON O
+GS PROPN B-AC
+, PUNCT O
+but CCONJ O
+( PUNCT O
+B NOUN O
+) PUNCT O
+neither CCONJ O
+the DET O
+WT PROPN B-AC
+nor CCONJ O
+the DET O
+truncated VERB O
+RGL PROPN O
+( PUNCT O
+RGL PROPN O
+trunc NOUN O
+) PUNCT O
+was AUX O
+pulled VERB O
+down ADP O
+by ADP O
+GST PROPN O
+- PUNCT O
+GN(297–333 NUM B-AC
+) PUNCT O
+. PUNCT O
+
+To PART O
+assess VERB O
+disease NOUN O
+activity NOUN O
+and CCONJ O
+allow VERB O
+comparison NOUN O
+between ADP O
+UC PROPN B-AC
+( PUNCT O
+Modified PROPN B-LF
+Truelove PROPN I-LF
+and CCONJ I-LF
+Witts PROPN I-LF
+activity NOUN I-LF
+index NOUN I-LF
+, PUNCT O
+MTWAI PROPN B-AC
+) PUNCT O
+and CCONJ O
+CD PROPN B-AC
+( PUNCT O
+Crohn PROPN O
+’s PART O
+disease NOUN O
+activity NOUN O
+index NOUN O
+, PUNCT O
+CDAI PROPN B-AC
+) PUNCT O
+, PUNCT O
+disease NOUN O
+activity NOUN O
+measures NOUN O
+were AUX O
+normalized VERB O
+to ADP O
+a DET O
+value NOUN O
+between ADP O
+0 NUM O
+and CCONJ O
+100 NUM O
+and CCONJ O
+expressed VERB O
+as ADP O
+an DET O
+activity NOUN O
+index NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+; PUNCT O
+creat NOUN B-AC
+, PUNCT O
+creatinine NOUN B-LF
+; PUNCT O
+cys NOUN B-AC
+, PUNCT O
+cystatin NOUN B-LF
+C NOUN I-LF
+; PUNCT O
+creat NOUN B-AC
+- PUNCT B-AC
+cys NOUN B-AC
+, PUNCT O
+creatinine NOUN B-LF
+and CCONJ I-LF
+cystatin NOUN I-LF
+C NOUN I-LF
+; PUNCT O
+CVD NOUN B-AC
+, PUNCT O
+cardiovascular ADJ B-LF
+disease NOUN I-LF
+; PUNCT O
+DBP PROPN B-AC
+, PUNCT O
+diastolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+; PUNCT O
+eGFR PROPN B-AC
+, PUNCT O
+estimated VERB B-LF
+glomerular ADJ I-LF
+filtration NOUN I-LF
+rate NOUN I-LF
+; PUNCT O
+hsCRP PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+sensitivity NOUN I-LF
+C NOUN I-LF
+- PUNCT I-LF
+reactive ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+SBP PROPN B-AC
+, PUNCT O
+systolic ADJ B-LF
+blood NOUN I-LF
+pressure NOUN I-LF
+; PUNCT O
+uACR PROPN B-AC
+, PUNCT O
+urine NOUN B-LF
+albumin NOUN I-LF
+- PUNCT I-LF
+to ADP I-LF
+- PUNCT I-LF
+creatinine NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+
+Using VERB O
+a DET O
+single ADJ O
+- PUNCT O
+center NOUN O
+prospective ADJ O
+study NOUN O
+design NOUN O
+, PUNCT O
+consecutive ADJ O
+patients NOUN O
+≥ VERB O
+18 NUM O
+years NOUN O
+with ADP O
+a DET O
+diagnosis NOUN O
+of ADP O
+acute ADJ O
+ischemic ADJ O
+stroke NOUN O
+/ SYM O
+TIA NOUN B-AC
+, PUNCT O
+intracerebral ADJ B-LF
+hemorrhage NOUN I-LF
+( PUNCT O
+ICH PROPN B-AC
+) PUNCT O
+, PUNCT O
+or CCONJ O
+subarachnoid ADJ B-LF
+hemorrhage NOUN I-LF
+( PUNCT O
+SAH PROPN B-AC
+) PUNCT O
+were AUX O
+consented VERB O
+and CCONJ O
+enrolled VERB O
+in ADP O
+the DET O
+Northwestern PROPN O
+University PROPN O
+Brain PROPN O
+Attack PROPN O
+Registry PROPN O
+. PUNCT O
+
+The DET O
+Reproductive PROPN B-LF
+Life PROPN I-LF
+Plan PROPN I-LF
+( PUNCT O
+RLP PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+clinical ADJ O
+tool NOUN O
+to PART O
+help VERB O
+clients NOUN O
+find VERB O
+strategies NOUN O
+to PART O
+achieve VERB O
+their PRON O
+reproductive ADJ O
+goals NOUN O
+. PUNCT O
+
+Dual ADJ B-AC
+- PUNCT B-AC
+LUC PROPN B-AC
+, PUNCT O
+transient ADJ B-LF
+transcription NOUN I-LF
+dual ADJ I-LF
+- PUNCT I-LF
+luciferase NOUN I-LF
+assay NOUN I-LF
+; PUNCT O
+EBP1 PROPN B-AC
+, PUNCT O
+ErbB3 PROPN O
+, PUNCT O
+binding VERB O
+protein NOUN O
+1 NUM O
+; PUNCT O
+LUC PROPN O
+, PUNCT O
+luciferase NOUN O
+; PUNCT O
+REN PROPN O
+, PUNCT O
+Renilla PROPN O
+luciferase NOUN O
+; PUNCT O
+RALF1 PROPN O
+, PUNCT O
+rapid ADJ O
+alkalinization NOUN O
+factor NOUN O
+1 NUM O
+. PUNCT O
+
+Abbreviations NOUN O
+: PUNCT O
+DS PROPN B-AC
+, PUNCT O
+diameter NOUN B-LF
+stenosis NOUN I-LF
+; PUNCT O
+FFR PROPN B-AC
+, PUNCT O
+fractional ADJ B-LF
+flow NOUN I-LF
+reserve NOUN I-LF
+; PUNCT O
+LAD NOUN B-AC
+, PUNCT O
+left ADJ B-LF
+anterior ADJ I-LF
+descending NOUN I-LF
+; PUNCT O
+LCX NOUN B-AC
+, PUNCT O
+left ADJ B-LF
+circumflex NOUN I-LF
+; PUNCT O
+MLD NOUN B-AC
+, PUNCT O
+minimal ADJ B-LF
+lumen NOUN I-LF
+diameter NOUN I-LF
+; PUNCT O
+RCA PROPN B-AC
+, PUNCT O
+right ADJ B-LF
+coronary ADJ I-LF
+artery NOUN I-LF
+; PUNCT O
+RLD NOUN B-AC
+, PUNCT O
+reference NOUN B-LF
+lumen NOUN I-LF
+diameter NOUN I-LF
+. PUNCT O
+
+Here ADV O
+, PUNCT O
+we PRON O
+investigated VERB O
+the DET O
+role NOUN O
+of ADP O
+gut NOUN O
+hormones NOUN O
+, PUNCT O
+pro ADJ O
+- ADJ O
+inflammatory ADJ O
+cytokines NOUN O
+and CCONJ O
+single ADJ B-LF
+nucleotide NOUN I-LF
+polymorphisms NOUN I-LF
+( PUNCT O
+SNPs NOUN B-AC
+) PUNCT O
+associated VERB O
+with ADP O
+TLR NOUN B-AC
+4p14 NUM O
+in ADP O
+H. PROPN O
+pylori PROPN O
+disease NOUN O
+in ADP O
+30 NUM O
+subjects NOUN O
+with ADP O
+non ADJ B-LF
+- ADJ I-LF
+ulcer NOUN I-LF
+dyspepsia NOUN I-LF
+( PUNCT O
+NUD PROPN B-AC
+) PUNCT O
+, PUNCT O
+40 NUM O
+with ADP O
+peptic ADJ B-LF
+ulcer NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+PUD PROPN B-AC
+) PUNCT O
+and CCONJ O
+15 NUM O
+with ADP O
+gastric ADJ B-LF
+cancer NOUN I-LF
+( PUNCT O
+GC PROPN B-AC
+) PUNCT O
+subjects NOUN O
+positive ADJ O
+and CCONJ O
+negative ADJ O
+for ADP O
+H. PROPN O
+pylori PROPN O
+infection NOUN O
+. PUNCT O
+
+AMI PROPN B-AC
+, PUNCT O
+acute ADJ B-LF
+myocardial ADJ I-LF
+infarction NOUN I-LF
+; PUNCT O
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+IRR PROPN B-AC
+, PUNCT O
+incidence NOUN B-LF
+rate NOUN I-LF
+ratio NOUN I-LF
+. PUNCT O
+
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+following VERB O
+the DET O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+guidelines NOUN O
+( PUNCT O
+S1 PROPN O
+STROBE PROPN B-AC
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+
+PGE2 PROPN B-AC
+signaling NOUN O
+is AUX O
+of ADP O
+particular ADJ O
+interest NOUN O
+given VERB O
+that SCONJ O
+( PUNCT O
+1 X O
+) PUNCT O
+PGE2 PROPN B-AC
+is AUX O
+able ADJ O
+to PART O
+induce VERB O
+decidualization NOUN O
+via ADP O
+cAMP NOUN B-AC
+signaling NOUN O
+in ADP O
+human ADJ O
+and CCONJ O
+rodent ADJ O
+ESFs PROPN B-AC
+[ PUNCT O
+12,14 NUM O
+] PUNCT O
+, PUNCT O
+( PUNCT O
+2 X O
+) PUNCT O
+the DET O
+PGE2 PROPN B-AC
+receptor NOUN O
+PTGER4 PROPN O
+is AUX O
+widely ADV O
+expressed VERB O
+in ADP O
+ESFs PROPN B-AC
+in ADP O
+mammals NOUN O
+[ PUNCT O
+16 NUM O
+] PUNCT O
+, PUNCT O
+and CCONJ O
+( PUNCT O
+3 X O
+) PUNCT O
+the DET O
+recent ADJ O
+finding NOUN O
+that SCONJ O
+prostaglandin NOUN B-LF
+synthase NOUN I-LF
+( PUNCT O
+PTGS PROPN B-AC
+, PUNCT O
+also ADV O
+known VERB O
+as ADP O
+“ PUNCT O
+COX2 PROPN O
+” PUNCT O
+) PUNCT O
+and CCONJ O
+prostaglandin NOUN B-LF
+E PROPN I-LF
+synthase NOUN I-LF
+( PUNCT O
+PTGES PROPN B-AC
+) PUNCT O
+are AUX O
+both PRON O
+expressed VERB O
+in ADP O
+the DET O
+opossum ADJ O
+uterus NOUN O
+after ADP O
+embryo NOUN O
+attachment NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+While SCONJ O
+LEP PROPN B-AC
+in ADP O
+this DET O
+study NOUN O
+perceived VERB O
+psychological ADJ O
+interventions NOUN O
+as ADP O
+contributing VERB O
+to ADP O
+their PRON O
+well NOUN O
+- PUNCT O
+being NOUN O
+, PUNCT O
+a DET O
+view NOUN O
+in ADP O
+line NOUN O
+with ADP O
+some DET O
+other ADJ O
+members NOUN O
+of ADP O
+LE PROPN B-AC
+[ PUNCT O
+6 NUM O
+, PUNCT O
+88 NUM O
+] PUNCT O
+, PUNCT O
+it PRON O
+is AUX O
+not PART O
+an DET O
+opinion NOUN O
+universally ADV O
+held VERB O
+within ADP O
+the DET O
+law NOUN B-LF
+enforcement NOUN I-LF
+literature NOUN O
+. PUNCT O
+
+Coomassie NOUN O
+staining NOUN O
+was AUX O
+used VERB O
+for ADP O
+loading NOUN O
+control NOUN O
+. PUNCT O
+( PUNCT O
+D X O
+and CCONJ O
+E X O
+) PUNCT O
+Pearson PROPN O
+regression NOUN O
+analysis NOUN O
+of ADP O
+FMOD PROPN B-AC
+mRNA NOUN O
+and CCONJ O
+( PUNCT O
+D X O
+) PUNCT O
+left ADJ O
+ventricular ADJ O
+weight NOUN O
+( PUNCT O
+LVW)/tibia NOUN O
+length NOUN O
+, PUNCT O
+or CCONJ O
+( PUNCT O
+E X O
+) PUNCT O
+lung NOUN O
+weight NOUN O
+( PUNCT O
+LW)/tibia NOUN O
+length NOUN O
+in ADP O
+sham- NOUN O
+and CCONJ O
+AB NOUN B-AC
+- PUNCT O
+operated VERB O
+mice NOUN O
+, PUNCT O
+n NOUN O
+= SYM O
+87 NUM O
+. PUNCT O
+( PUNCT O
+F X O
+) PUNCT O
+FMOD PROPN B-AC
+, PUNCT O
+lumican NOUN B-LF
+( PUNCT O
+LUM PROPN B-AC
+) PUNCT O
+, PUNCT O
+biglycan NOUN B-LF
+( PUNCT O
+BGN PROPN B-AC
+) PUNCT O
+and CCONJ O
+decorin NOUN B-LF
+( PUNCT O
+DCN PROPN B-AC
+) PUNCT O
+mRNA NOUN O
+normalized VERB O
+to ADP O
+RPL32 PROPN O
+in ADP O
+LVs NOUN B-AC
+of ADP O
+mice NOUN O
+24h-18w NUM O
+post ADJ O
+- PUNCT O
+AB NOUN B-AC
+, PUNCT O
+relative ADJ O
+to ADP O
+the DET O
+average NOUN O
+of ADP O
+sham NOUN O
+- PUNCT O
+operated VERB O
+controls NOUN O
+, PUNCT O
+n NOUN O
+sham NOUN O
+= SYM O
+3–10 NUM O
+, PUNCT O
+n NOUN O
+AB NOUN B-AC
+= SYM O
+7–10 NUM O
+. PUNCT O
+
+iESR PROPN B-AC
+, PUNCT O
+induced VERB B-LF
+- PUNCT I-LF
+Environmental ADJ I-LF
+Stress PROPN I-LF
+Response PROPN I-LF
+; PUNCT O
+RP PROPN B-AC
+, PUNCT O
+ribosomal ADJ B-LF
+protein NOUN I-LF
+. PUNCT O
+
+The DET O
+cytokine NOUN O
+profiles NOUN O
+of ADP O
+individual ADJ O
+samples NOUN O
+were AUX O
+analyzed VERB O
+with ADP O
+t NOUN B-LF
+- ADJ I-LF
+distributed VERB I-LF
+stochastic ADJ I-LF
+neighbor NOUN I-LF
+embedding NOUN I-LF
+( PUNCT O
+tSNE PROPN B-AC
+) PUNCT O
+[ X O
+30 NUM O
+] X O
+implemented VERB O
+in ADP O
+R PROPN O
+( PUNCT O
+version NOUN O
+3.2.3 NUM O
+) PUNCT O
+. PUNCT O
+
+Fifty NUM O
+- NOUN O
+three NUM O
+of ADP O
+these DET O
+subjects NOUN O
+underwent VERB O
+dual ADJ B-LF
+energy NOUN I-LF
+X NOUN I-LF
+- NOUN I-LF
+ray NOUN I-LF
+absorptiometry NOUN I-LF
+( PUNCT O
+DXA PROPN B-AC
+) PUNCT O
+measurements NOUN O
+of ADP O
+adipose ADJ O
+tissue NOUN O
+mass NOUN O
+and CCONJ O
+distribution NOUN O
+. PUNCT O
+
+Microbial ADJ O
+products NOUN O
+are AUX O
+largely ADV O
+recognized VERB O
+by ADP O
+germ NOUN O
+- PUNCT O
+line NOUN O
+encoded VERB O
+innate ADJ O
+immune ADJ O
+sensors NOUN O
+like ADJ O
+toll NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+receptors NOUN I-LF
+( PUNCT O
+TLRs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+On ADP O
+- PUNCT O
+track NOUN O
+cognitive ADJ O
+development NOUN O
+was AUX O
+associated VERB O
+with ADP O
+improved ADJ O
+housing NOUN O
+( PUNCT O
+odds NOUN B-LF
+ratio NOUN I-LF
+[ PUNCT O
+OR NOUN B-AC
+] X O
+= SYM O
+1.15 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.06 NUM O
+to PART O
+1.24 NUM O
+, PUNCT O
+p NOUN O
+< NOUN O
+0.001 NUM O
+) PUNCT O
+, PUNCT O
+improved ADJ O
+drinking NOUN O
+water NOUN O
+( PUNCT O
+OR NOUN B-AC
+= SYM O
+1.07 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.00 NUM O
+to PART O
+1.14 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.046 NUM O
+) PUNCT O
+, PUNCT O
+improved ADJ O
+sanitation NOUN O
+facilities NOUN O
+( PUNCT O
+OR NOUN B-AC
+= SYM O
+1.15 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.03 NUM O
+to PART O
+1.28 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.014 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+sufficient ADJ O
+living NOUN O
+area NOUN O
+( PUNCT O
+OR NOUN B-AC
+= SYM O
+1.06 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.01 NUM O
+to PART O
+1.10 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.018 NUM O
+) PUNCT O
+. PUNCT O
+
+The DET O
+amount NOUN O
+of ADP O
+nicked VERB O
+product NOUN O
+( PUNCT O
+n NOUN O
+) PUNCT O
+and CCONJ O
+linear ADJ O
+product NOUN O
+( PUNCT O
+black ADJ O
+triangle NOUN O
+) PUNCT O
+was AUX O
+quantified VERB O
+as ADP O
+a DET O
+fraction NOUN O
+of ADP O
+the DET O
+total ADJ O
+starting VERB O
+closed VERB B-LF
+circular ADJ I-LF
+substrate NOUN I-LF
+( PUNCT O
+cc NOUN B-AC
+) PUNCT O
+. PUNCT O
+( PUNCT O
+B X O
+) PUNCT O
+Average NOUN O
+of ADP O
+three NUM O
+separate ADJ O
+experiments NOUN O
+is AUX O
+plotted VERB O
+. PUNCT O
+
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+. PUNCT O
+
+To ADP O
+date NOUN O
+, PUNCT O
+many ADJ O
+studies NOUN O
+have AUX O
+been AUX O
+performed VERB O
+, PUNCT O
+and CCONJ O
+thousands NOUN O
+of ADP O
+differentially ADV B-LF
+expressed VERB I-LF
+genes NOUN I-LF
+( PUNCT O
+DEGs NOUN B-AC
+) PUNCT O
+have AUX O
+been AUX O
+screened VERB O
+. PUNCT O
+
+However ADV O
+, PUNCT O
+as ADP O
+an DET O
+unsupervised ADJ O
+topic NOUN O
+model NOUN O
+that PRON O
+can AUX O
+reflect VERB O
+the DET O
+continuous ADJ O
+and CCONJ O
+dynamic ADJ O
+evolutional ADJ O
+characteristics NOUN O
+of ADP O
+documents NOUN O
+, PUNCT O
+the DET O
+dynamic ADJ B-LF
+topic NOUN I-LF
+model NOUN I-LF
+( PUNCT O
+DTM PROPN B-AC
+) PUNCT O
+is AUX O
+also ADV O
+adopted VERB O
+by ADP O
+many ADJ O
+researchers NOUN O
+. PUNCT O
+
+White ADJ O
+arrows NOUN O
+indicate VERB O
+conidia NOUN O
+of ADP O
+interest NOUN O
+at ADP O
+key ADJ O
+points NOUN O
+in ADP O
+the DET O
+transfer NOUN O
+process NOUN O
+. PUNCT O
+cwh NOUN B-AC
+, PUNCT O
+A. NOUN O
+fumigatus NOUN O
+α NOUN O
+- PUNCT O
+glucosidase NOUN O
+1 NUM O
+; PUNCT O
+gel NOUN B-AC
+, PUNCT O
+A. NOUN B-LF
+fumigatus NOUN I-LF
+β-1,3 NOUN I-LF
+- PUNCT I-LF
+glucanosyltransferase NOUN I-LF
+. PUNCT O
+
+Multivariate ADJ O
+Cox PROPN O
+proportional ADJ O
+hazard NOUN O
+analysis NOUN O
+was AUX O
+used VERB O
+to PART O
+estimate VERB O
+the DET O
+hazard NOUN B-LF
+ratio NOUN I-LF
+( PUNCT O
+HR NOUN B-AC
+) PUNCT O
+of ADP O
+CHD NOUN B-AC
+and CCONJ O
+mortality NOUN O
+, PUNCT O
+and CCONJ O
+the DET O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+among ADP O
+H. PROPN B-AC
+pylori NOUN B-AC
+eradication NOUN O
+, PUNCT O
+non ADJ O
+- ADJ O
+H. PROPN B-AC
+pylori NOUN B-AC
+eradication NOUN O
+, PUNCT O
+early ADJ O
+H. PROPN B-AC
+pylori NOUN B-AC
+eradication NOUN O
+and CCONJ O
+non ADJ O
+- ADJ O
+early ADJ O
+H. PROPN B-AC
+pylori NOUN B-AC
+eradication NOUN O
+groups NOUN O
+. PUNCT O
+
+GPi PROPN B-AC
+, PUNCT O
+globus NOUN B-LF
+pallidus NOUN I-LF
+- PUNCT I-LF
+internus NOUN I-LF
+; PUNCT O
+VLa PROPN B-AC
+, PUNCT O
+ventrolateral ADJ B-LF
+anterior ADJ I-LF
+nucleus NOUN I-LF
+. PUNCT O
+
+Box NOUN O
+and CCONJ O
+whisker NOUN O
+plots NOUN O
+of ADP O
+mRNA NOUN O
+abundances NOUN O
+of ADP O
+PRA PROPN B-AC
+and CCONJ O
+PRB PROPN B-AC
+, PUNCT O
+ERα PROPN O
+, PUNCT O
+ERβ PROPN O
+, PUNCT O
+IL-8 NOUN B-AC
+, PUNCT O
+COX-2 NOUN B-AC
+, PUNCT O
+MnSOD PROPN B-AC
+, PUNCT O
+β2 NOUN B-LF
+- ADJ I-LF
+microglobulin NOUN I-LF
+( PUNCT O
+β2μ NOUN B-AC
+) PUNCT O
+, PUNCT O
+connexin-43 NOUN B-LF
+( PUNCT O
+CX-43 NOUN B-AC
+) PUNCT O
+, PUNCT O
+OTR PROPN B-AC
+, PUNCT O
+and CCONJ O
+the DET O
+homeobox NOUN O
+gene NOUN O
+HoxA10 PROPN O
+in ADP O
+labouring ADJ O
+( PUNCT O
+L NOUN O
+) PUNCT O
+and CCONJ O
+non ADJ O
+- ADJ O
+labouring ADJ O
+( PUNCT O
+N NOUN O
+) PUNCT O
+women NOUN O
+. PUNCT O
+
+We PRON O
+studied VERB O
+two NUM O
+population NOUN O
+- PUNCT O
+based VERB O
+birth NOUN O
+cohorts NOUN O
+from ADP O
+the DET O
+UK PROPN O
+: PUNCT O
+the DET O
+Avon PROPN B-LF
+Longitudinal PROPN I-LF
+Study PROPN I-LF
+of ADP I-LF
+Parents PROPN I-LF
+and CCONJ I-LF
+Children PROPN I-LF
+( PUNCT O
+ALSPAC PROPN B-AC
+) PUNCT O
+[ PUNCT O
+35 NUM O
+] PUNCT O
+and CCONJ O
+the DET O
+Manchester PROPN B-LF
+Asthma PROPN I-LF
+and CCONJ I-LF
+Allergy PROPN I-LF
+Study PROPN I-LF
+( PUNCT O
+MAAS PROPN B-AC
+) PUNCT O
+[ PUNCT O
+36 NUM O
+] PUNCT O
+. PUNCT O
+
+Primer NOUN O
+pairs NOUN O
+for ADP O
+plasminogen NOUN B-LF
+activator NOUN I-LF
+inhibitor NOUN I-LF
+( PUNCT O
+PAI)-1 PROPN B-AC
+, PUNCT O
+DNA NOUN O
+methyltransferase NOUN O
+( PUNCT O
+DNMT PROPN O
+) PUNCT O
+-1 NUM O
+, PUNCT O
+-3a NOUN O
+and CCONJ O
+-3b NOUN O
+, PUNCT O
+fatty ADJ B-LF
+acid NOUN I-LF
+synthase NOUN I-LF
+( PUNCT O
+FAS PROPN B-AC
+) PUNCT O
+and CCONJ O
+sphingosine NOUN B-LF
+kinase NOUN I-LF
+( PUNCT O
+SPHK)-1 PROPN B-AC
+were AUX O
+designed VERB O
+( PUNCT O
+Table PROPN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+GFP PROPN O
+, PUNCT O
+green ADJ O
+fluorescent ADJ O
+protein NOUN O
+; PUNCT O
+PA PROPN B-AC
+, PUNCT O
+protein NOUN B-LF
+aggregate NOUN I-LF
+; PUNCT O
+TLFM PROPN B-AC
+, PUNCT O
+time NOUN B-LF
+- PUNCT I-LF
+lapse NOUN I-LF
+fluorescence NOUN I-LF
+microscopy NOUN I-LF
+. PUNCT O
+
+To PART O
+identify VERB O
+additional ADJ O
+published VERB O
+and CCONJ O
+unpublished ADJ O
+data NOUN O
+, PUNCT O
+we PRON O
+contacted VERB O
+experts NOUN O
+in ADP O
+the DET O
+field NOUN O
+of ADP O
+pediatric ADJ O
+MDR PROPN B-AC
+- PROPN B-AC
+TB PROPN B-AC
+. PUNCT O
+We PRON O
+also ADV O
+requested VERB O
+data NOUN O
+through ADP O
+other ADJ O
+routes NOUN O
+, PUNCT O
+including VERB O
+at ADP O
+national ADJ O
+and CCONJ O
+international ADJ O
+conferences NOUN O
+and CCONJ O
+training NOUN O
+events NOUN O
+, PUNCT O
+and CCONJ O
+through ADP O
+international ADJ O
+and CCONJ O
+in ADP O
+- PROPN O
+country NOUN O
+organizations NOUN O
+working VERB O
+in ADP O
+pediatric ADJ O
+MDR PROPN B-AC
+- PROPN B-AC
+TB PROPN B-AC
+, PUNCT O
+including VERB O
+the DET O
+Sentinel PROPN O
+Project PROPN O
+on ADP O
+Pediatric PROPN O
+Drug PROPN O
+- PROPN O
+Resistant PROPN O
+Tuberculosis PROPN B-LF
+, PUNCT O
+the DET O
+WHO PROPN B-AC
+Childhood PROPN O
+TB PROPN B-AC
+Sub PROPN O
+- PROPN O
+Group PROPN O
+, PUNCT O
+Médecins PROPN B-LF
+Sans PROPN I-LF
+Frontières PROPN I-LF
+( PUNCT O
+MSF PROPN B-AC
+) PUNCT O
+, PUNCT O
+the DET O
+United PROPN O
+States PROPN O
+Centers PROPN O
+for ADP O
+Disease PROPN O
+Control PROPN O
+and CCONJ O
+Prevention PROPN O
+( PUNCT O
+CDC PROPN O
+) PUNCT O
+and CCONJ O
+European PROPN B-LF
+Centre PROPN I-LF
+for ADP I-LF
+Disease PROPN I-LF
+Prevention PROPN I-LF
+and CCONJ I-LF
+Control PROPN I-LF
+( PUNCT O
+ECDC PROPN B-AC
+) PUNCT O
+, PUNCT O
+The DET O
+Union PROPN O
+, PUNCT O
+and CCONJ O
+the DET O
+National PROPN B-LF
+Institutes PROPN I-LF
+of ADP I-LF
+Health PROPN I-LF
+( PUNCT O
+NIH PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Additionally ADV O
+, PUNCT O
+textbooks NOUN O
+addressing VERB O
+the DET O
+methodology NOUN O
+of ADP O
+clinical ADJ O
+trials NOUN O
+and CCONJ O
+International PROPN B-LF
+Conference PROPN I-LF
+on ADP I-LF
+Harmonisation PROPN I-LF
+of ADP I-LF
+Technical PROPN I-LF
+Requirements PROPN I-LF
+for ADP I-LF
+Registration PROPN I-LF
+of ADP I-LF
+Pharmaceuticals PROPN I-LF
+for ADP I-LF
+Human PROPN I-LF
+Use PROPN I-LF
+( PUNCT O
+ICH PROPN B-AC
+) PUNCT O
+tripartite ADJ O
+guidelines NOUN O
+for ADP O
+clinical ADJ O
+trials NOUN O
+were AUX O
+also ADV O
+consulted VERB O
+. PUNCT O
+
+Effects NOUN O
+of ADP O
+norepinephrine NOUN B-LF
+bitartrate NOUN I-LF
+( PUNCT O
+NB PROPN B-AC
+) PUNCT O
+treatment NOUN O
+at ADP O
+2 NUM O
+dpf NOUN B-AC
+for ADP O
+24 NUM O
+h NOUN O
+on ADP O
+the DET O
+heartbeat NOUN O
+( PUNCT O
+A NOUN O
+; PUNCT O
+139.3±2.8 NUM O
+/ SYM O
+min NOUN O
+in ADP O
+control NOUN O
+group NOUN O
+, PUNCT O
+166.3±2.1 NUM O
+/ SYM O
+min NOUN O
+in ADP O
+NT PROPN O
+- PUNCT O
+treated VERB O
+group NOUN O
+) PUNCT O
+and CCONJ O
+the DET O
+average ADJ O
+velocity NOUN O
+of ADP O
+midbrain NOUN O
+blood NOUN O
+flow NOUN O
+( PUNCT O
+B NOUN O
+; PUNCT O
+0.26±0.02 NUM O
+mm NOUN O
+/ SYM O
+s NOUN O
+in ADP O
+control NOUN O
+group NOUN O
+, PUNCT O
+0.38±0.04 NUM O
+mm NOUN O
+/ SYM O
+s NOUN O
+in ADP O
+NT PROPN O
+- PUNCT O
+treated VERB O
+group NOUN O
+) PUNCT O
+measured VERB O
+at ADP O
+3 NUM O
+dpf NOUN B-AC
+. PUNCT O
+
+We PRON O
+chose VERB O
+to PART O
+use VERB O
+mesenchymal ADJ B-LF
+stem NOUN I-LF
+cells NOUN I-LF
+( PUNCT O
+MSCs PROPN B-AC
+) PUNCT O
+because SCONJ O
+they PRON O
+can AUX O
+be AUX O
+isolated VERB O
+directly ADV O
+from ADP O
+transgenic ADJ O
+mouse NOUN O
+models NOUN O
+of ADP O
+interest NOUN O
+and CCONJ O
+are AUX O
+highly ADV O
+adipogenic ADJ O
+[ PUNCT O
+18 NUM O
+] PUNCT O
+. PUNCT O
+
+BM PROPN B-AC
+, PUNCT O
+bone NOUN B-LF
+marrow NOUN I-LF
+. PUNCT O
+
+We PRON O
+examined VERB O
+associations NOUN O
+between ADP O
+TBI PROPN B-AC
+history NOUN O
+and CCONJ O
+MH PROPN B-AC
+service NOUN O
+utilization NOUN O
+in ADP O
+a DET O
+subsample NOUN O
+of ADP O
+returning VERB O
+veterans NOUN O
+who PRON O
+were AUX O
+newly ADV O
+diagnosed VERB O
+with ADP O
+posttraumatic ADJ B-LF
+stress NOUN I-LF
+disorder NOUN I-LF
+( PUNCT O
+PTSD PROPN B-AC
+) PUNCT O
+, PUNCT O
+depression NOUN O
+, PUNCT O
+and/or CCONJ O
+anxiety NOUN O
+in ADP O
+the DET O
+2010 NUM O
+fiscal ADJ O
+year NOUN O
+( PUNCT O
+N NOUN O
+= SYM O
+55,458 NUM O
+) PUNCT O
+. PUNCT O
+
+We PRON O
+called VERB O
+it PRON O
+" PUNCT O
+Innovative PROPN B-LF
+Mobile PROPN I-LF
+- PUNCT I-LF
+phone PROPN I-LF
+Technology PROPN I-LF
+for ADP I-LF
+Community PROPN I-LF
+Health PROPN I-LF
+Operations PROPN I-LF
+" PUNCT O
+( PUNCT O
+ImTeCHO PROPN B-AC
+) PUNCT O
+[ X O
+22,23 NUM O
+] PUNCT O
+. PUNCT O
+
+ATCC PROPN B-AC
+, PUNCT O
+American PROPN B-LF
+Type PROPN I-LF
+Culture PROPN I-LF
+Collection PROPN I-LF
+; PUNCT O
+NanA PROPN B-AC
+, PUNCT O
+N NOUN B-LF
+- NOUN I-LF
+acetylneuraminate NOUN I-LF
+lyase NOUN I-LF
+. PUNCT O
+
+Fat PROPN B-LF
+Free PROPN I-LF
+Mass NOUN I-LF
+equation NOUN O
+: PUNCT O
+FFM NOUN B-AC
+= SYM O
+Fat PROPN B-LF
+Free PROPN I-LF
+Mass NOUN I-LF
+; PUNCT O
+kg NOUN O
+= SYM O
+kilograms NOUN O
+. PUNCT O
+
+Langerhans PROPN B-LF
+cell NOUN I-LF
+histiocytosis NOUN I-LF
+( PUNCT O
+LCH PROPN B-AC
+) PUNCT O
+is AUX O
+a DET O
+rare ADJ O
+clonal ADJ O
+granulomatous ADJ O
+disease NOUN O
+that PRON O
+affects VERB O
+mainly ADV O
+children NOUN O
+. PUNCT O
+
+The DET O
+postoperative ADJ B-LF
+IP PROPN B-AC
+VEGF PROPN B-AC
+- PUNCT B-AC
+A PROPN B-AC
+in ADP O
+the DET O
+major NOUN O
+group NOUN O
+was AUX O
+significantly ADV O
+elevated ADJ O
+as ADP O
+compared VERB O
+to ADP O
+the DET O
+minor ADJ O
+group NOUN O
+( PUNCT O
+median ADJ O
+IP PROPN B-AC
+VEGF PROPN B-AC
+- PUNCT B-AC
+A PROPN B-AC
+× SYM O
+106 NUM O
+platelets NOUN O
+: PUNCT O
+POST PROPN B-AC
+OP NOUN B-AC
+major NOUN O
+, PUNCT O
+1.938 NUM O
+pg NOUN O
+; PUNCT O
+POST PROPN B-AC
+OP NOUN B-AC
+minor ADJ O
+, PUNCT O
+0.786 NUM O
+pg NOUN O
+; PUNCT O
+P<0.001 NUM O
+) PUNCT O
+. PUNCT O
+
+BSI PROPN B-AC
+, PUNCT O
+bloodstream NOUN B-LF
+infection NOUN I-LF
+; PUNCT O
+UTI NOUN B-AC
+, PUNCT O
+urinary ADJ B-LF
+tract NOUN I-LF
+infection NOUN I-LF
+. PUNCT O
+
+Seasonal ADJ O
+modulation NOUN O
+may AUX O
+account VERB O
+for ADP O
+the DET O
+observation NOUN O
+that SCONJ O
+some DET O
+individuals NOUN O
+with ADP O
+mild ADJ B-LF
+cognitive ADJ I-LF
+impairment NOUN I-LF
+( PUNCT O
+MCI PROPN B-AC
+) PUNCT O
+subsequently ADV O
+revert VERB O
+to ADP O
+normal ADJ O
+cognition NOUN O
+, PUNCT O
+and CCONJ O
+may AUX O
+be AUX O
+an DET O
+important ADJ O
+source NOUN O
+of ADP O
+diagnostic ADJ O
+misclassification NOUN O
+both CCONJ O
+in ADP O
+clinical ADJ O
+trials NOUN O
+and CCONJ O
+in ADP O
+clinical ADJ O
+practice NOUN O
+. PUNCT O
+
+Underlying VERB O
+data NOUN O
+can AUX O
+be AUX O
+found VERB O
+in ADP O
+S1 PROPN O
+Data PROPN O
+. PUNCT O
+5 NUM B-AC
+- PUNCT B-AC
+HT NOUN B-AC
+, PUNCT O
+serotonin NOUN B-LF
+; PUNCT O
+CV PROPN O
+, PUNCT O
+circumvallate NOUN O
+; PUNCT O
+HFD PROPN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+fat NOUN I-LF
+diet NOUN I-LF
+; PUNCT O
+KCNQ1 PROPN B-AC
+, PUNCT O
+potassium NOUN B-LF
+voltage NOUN I-LF
+- PUNCT I-LF
+gated VERB I-LF
+channel NOUN I-LF
+subfamily NOUN I-LF
+Q NOUN I-LF
+member NOUN I-LF
+1 NUM I-LF
+; PUNCT O
+Ki67 PROPN B-AC
+, PUNCT O
+Antigen NOUN B-LF
+KI-67 PROPN I-LF
+; PUNCT O
+KO PROPN O
+, PUNCT O
+knockout NOUN O
+; PUNCT O
+NTPDase2 PROPN B-AC
+, PUNCT O
+ectonucleoside NOUN B-LF
+triphosphate NOUN I-LF
+diphosphohydrolase NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+PBS PROPN B-AC
+, PUNCT O
+phosphate NOUN B-LF
+buffered VERB I-LF
+saline NOUN I-LF
+; PUNCT O
+PLCβ2 PROPN B-AC
+, PUNCT O
+phospholipase NOUN B-LF
+C NOUN I-LF
+beta NOUN I-LF
+2 NUM I-LF
+; PUNCT O
+SEM PROPN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+; PUNCT O
+TNFα PROPN B-AC
+, PUNCT O
+tumor NOUN B-LF
+necrosis NOUN I-LF
+factor NOUN I-LF
+α NOUN I-LF
+; PUNCT O
+WT PROPN B-AC
+, PUNCT O
+wild ADJ B-LF
+- PUNCT I-LF
+type NOUN I-LF
+. PUNCT O
+
+To PART O
+determine VERB O
+BPD PROPN B-AC
+diagnoses NOUN O
+, PUNCT O
+interviewers NOUN O
+further ADV O
+administered VERB O
+the DET O
+International PROPN O
+Personality PROPN O
+Disorder PROPN O
+Examination PROPN O
+[ PUNCT O
+IPDE PROPN O
+, PUNCT O
+45 NUM O
+] PUNCT O
+and CCONJ O
+the DET O
+Zanarini PROPN O
+Rating PROPN O
+Scale PROPN O
+for ADP O
+Borderline PROPN B-LF
+Personality PROPN I-LF
+Disorder PROPN I-LF
+[ PUNCT O
+ZAN PROPN O
+- PUNCT O
+BPD PROPN B-AC
+, PUNCT O
+46 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+mannoside NOUN O
+caps NOUN O
+of ADP O
+ManLAM PROPN O
+in ADP O
+MTB PROPN B-AC
+may AUX O
+be AUX O
+further ADV O
+substituted VERB O
+with ADP O
+a DET O
+unique ADJ O
+methylthio NOUN B-LF
+- NOUN I-LF
+D NOUN I-LF
+- NOUN I-LF
+xylose NOUN I-LF
+( PUNCT O
+MTX PROPN B-AC
+) PUNCT O
+residue NOUN O
+[ PUNCT O
+17 NUM O
+] PUNCT O
+. PUNCT O
+
+Resistance NOUN O
+to ADP O
+tumor NOUN B-LF
+necrosis NOUN I-LF
+factor NOUN I-LF
+- PUNCT I-LF
+related VERB I-LF
+apoptosis NOUN I-LF
+- PUNCT I-LF
+inducing VERB I-LF
+ligand NOUN I-LF
+( PUNCT O
+TRAIL)-induced PROPN B-AC
+apoptosis NOUN O
+has AUX O
+been AUX O
+reported VERB O
+in ADP O
+some DET O
+cancer NOUN O
+cells NOUN O
+, PUNCT O
+including VERB O
+AGS PROPN O
+human ADJ O
+gastric ADJ O
+adenocarcinoma NOUN O
+cells NOUN O
+. PUNCT O
+
+BV NOUN B-AC
+, PUNCT O
+biliverdin NOUN B-LF
+; PUNCT O
+OD NOUN O
+, PUNCT O
+optical ADJ O
+density NOUN O
+; PUNCT O
+SEM NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+of ADP I-LF
+the DET I-LF
+mean NOUN I-LF
+; PUNCT O
+WT NOUN B-AC
+, PUNCT O
+wild ADJ B-LF
+type NOUN I-LF
+. PUNCT O
+
+BPD NOUN B-AC
+: PUNCT O
+bronchopulmonary ADJ B-LF
+dysplasia NOUN I-LF
+; PUNCT O
+CLD NOUN B-AC
+: PUNCT O
+chronic ADJ B-LF
+lung NOUN I-LF
+disease NOUN I-LF
+; PUNCT O
+CVL NOUN B-AC
+: PUNCT O
+central ADJ B-LF
+venous ADJ I-LF
+line NOUN I-LF
+; PUNCT O
+NEC NOUN B-AC
+: PUNCT O
+necrotizing VERB B-LF
+enterocolitis NOUN I-LF
+; PUNCT O
+PDA NOUN B-AC
+: PUNCT O
+patent NOUN B-LF
+ductus NOUN I-LF
+arteriosus NOUN I-LF
+; PUNCT O
+SD NOUN B-AC
+: PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+; PUNCT O
+WGA PROPN B-AC
+: PUNCT O
+weeks NOUN B-LF
+of ADP I-LF
+gestational ADJ I-LF
+age NOUN I-LF
+. PUNCT O
+
+In ADP O
+response NOUN O
+to ADP O
+the DET O
+Earth PROPN O
+’s PART O
+predictable ADJ O
+light NOUN B-LF
+- PUNCT I-LF
+dark ADJ I-LF
+( PUNCT O
+LD NOUN B-AC
+) PUNCT O
+cycles NOUN O
+, PUNCT O
+many ADJ O
+organisms NOUN O
+have AUX O
+evolved VERB O
+a DET O
+circadian ADJ O
+clock NOUN O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+In ADP O
+contrast NOUN O
+to ADP O
+ESBL PROPN O
+, PUNCT O
+AmpC PROPN B-LF
+beta NOUN I-LF
+- NOUN I-LF
+lactamase NOUN I-LF
+activity NOUN O
+is AUX O
+not PART O
+affected VERB O
+by ADP O
+ESBLs PROPN B-AC
+inhibitors NOUN O
+[ PUNCT O
+11 NUM O
+] PUNCT O
+. PUNCT O
+
+GFP PROPN B-AC
+, PUNCT O
+green ADJ B-LF
+fluorescent ADJ I-LF
+protein NOUN I-LF
+; PUNCT O
+UAS PROPN B-AC
+, PUNCT O
+upstream ADJ B-LF
+activating VERB I-LF
+sequence NOUN I-LF
+. PUNCT O
+
+HEK293 PROPN O
+FT NOUN O
+cells NOUN O
+were AUX O
+plated VERB O
+on ADP O
+poly ADJ O
+- PUNCT O
+d ADJ O
+- PUNCT O
+lysine NOUN O
+coated VERB O
+glass NOUN O
+coverslips NOUN O
+in ADP O
+6 NUM O
+well NOUN O
+plates NOUN O
+and CCONJ O
+transfected VERB O
+with ADP O
+0.5 NUM O
+g NOUN O
+eYFP NOUN O
+CAAX PROPN O
+per ADP O
+well NOUN O
+using VERB O
+polyethylenimine NOUN B-LF
+( PUNCT O
+PEI NOUN B-AC
+) PUNCT O
+at ADP O
+a DET O
+ratio NOUN O
+of ADP O
+1 NUM O
+g NOUN O
+DNA NOUN O
+to ADP O
+6 NUM O
+g NOUN O
+PEI NOUN B-AC
+. PUNCT O
+Prior ADV O
+to ADP O
+imaging NOUN O
+, PUNCT O
+cells NOUN O
+were AUX O
+treated VERB O
+for ADP O
+12 NUM O
+h NOUN O
+with ADP O
+the DET O
+NO PROPN B-AC
+donor NOUN O
+DETA PROPN O
+- PUNCT O
+NONOate PROPN O
+or CCONJ O
+a DET O
+combination NOUN O
+of ADP O
+the DET O
+farnesyl NOUN O
+transferase NOUN O
+inhibitor NOUN O
+L-744,832 PROPN O
+( PUNCT O
+20 NUM O
+μM NOUN O
+) PUNCT O
+and CCONJ O
+the DET O
+geranylgeranyltransferase NOUN O
+I NOUN O
+inhibitor NOUN O
+GGTI-298 PROPN O
+( PUNCT O
+20 NUM O
+μM NOUN O
+) PUNCT O
+. PUNCT O
+Cells NOUN O
+were AUX O
+then ADV O
+washed VERB O
+3 NUM O
+times NOUN O
+with ADP O
+PBS PROPN O
+and CCONJ O
+fixed VERB O
+for ADP O
+15 NUM O
+min NOUN O
+with ADP O
+4 NUM O
+% NOUN O
+paraformaldehyde NOUN O
+. PUNCT O
+
+3D PROPN O
+- PUNCT O
+Fast PROPN O
+Gray PROPN O
+Matter PROPN O
+Acquisition PROPN O
+with ADP O
+Phase PROPN O
+Sensitive PROPN O
+Inversion PROPN O
+Recovery PROPN O
+( PUNCT O
+3D PROPN B-AC
+- PUNCT B-AC
+FGAPSIR PROPN B-AC
+) PUNCT O
+real ADV O
+- PUNCT O
+corrected VERB O
+( PUNCT O
+a DET O
+) PUNCT O
+and CCONJ O
+second ADJ O
+magnitude NOUN O
+( PUNCT O
+b NOUN O
+) PUNCT O
+images NOUN O
+reformatted VERB O
+in ADP O
+the DET O
+sagittal ADJ O
+plane NOUN O
+showing VERB O
+a DET O
+single ADJ O
+left ADJ O
+posterior ADJ O
+cervical ADJ O
+spinal ADJ O
+cord NOUN O
+lesion NOUN O
+( PUNCT O
+arrow NOUN O
+) PUNCT O
+, PUNCT O
+whereas SCONJ O
+no DET O
+lesion NOUN O
+was AUX O
+detected VERB O
+on ADP O
+both CCONJ O
+3D PROPN O
+- PUNCT O
+Short PROPN B-LF
+- PUNCT I-LF
+Tau PROPN I-LF
+Inversion PROPN I-LF
+Recovery PROPN I-LF
+( PUNCT O
+STIR PROPN B-AC
+) PUNCT O
+reformatted VERB O
+in ADP O
+the DET O
+sagittal ADJ O
+plane NOUN O
+( PUNCT O
+c NOUN O
+) PUNCT O
+or CCONJ O
+sagittal ADJ O
+T2 NOUN O
+- PUNCT O
+weighted VERB O
+imaging NOUN O
+( PUNCT O
+d NOUN O
+) PUNCT O
+. PUNCT O
+3D PROPN B-AC
+- PUNCT B-AC
+FGAPSIR PROPN B-AC
+real ADV O
+- PUNCT O
+corrected VERB O
+image NOUN O
+reformatted VERB O
+in ADP O
+the DET O
+axial ADJ O
+plane NOUN O
+( PUNCT O
+e NOUN O
+) PUNCT O
+confirming VERB O
+and CCONJ O
+precisely ADV O
+localizing VERB O
+the DET O
+lesion NOUN O
+, PUNCT O
+whereas SCONJ O
+no DET O
+lesion NOUN O
+was AUX O
+detected VERB O
+on ADP O
+3D PROPN O
+- PUNCT O
+STIR PROPN B-AC
+reformatted VERB O
+in ADP O
+the DET O
+axial ADJ O
+plane NOUN O
+( PUNCT O
+f NOUN O
+) PUNCT O
+. PUNCT O
+
+When SCONJ O
+a DET O
+log ADJ O
+- ADJ O
+linear ADJ O
+model NOUN O
+was AUX O
+used VERB O
+, PUNCT O
+relative ADJ O
+risk NOUN O
+of ADP O
+cancer NOUN O
+per ADP O
+10 NUM O
+mGy NOUN O
+of ADP O
+in ADP O
+utero NOUN O
+dose NOUN O
+was AUX O
+0.99 NUM O
+( PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+( PUNCT O
+CI NOUN B-AC
+) PUNCT O
+= SYM O
+0.96 NUM O
+to PART O
+1.01 NUM O
+) PUNCT O
+based VERB O
+on ADP O
+incidence NOUN O
+data NOUN O
+and CCONJ O
+0.98 NUM O
+( PUNCT O
+CI NOUN B-AC
+= SYM O
+0.94 NUM O
+to PART O
+1.01 NUM O
+) PUNCT O
+based VERB O
+on ADP O
+mortality NOUN O
+data NOUN O
+. PUNCT O
+
+CI NOUN O
+= PUNCT O
+confidence NOUN O
+interval NOUN O
+; PUNCT O
+hs NOUN O
+- PUNCT O
+cTnT NOUN O
+= PUNCT O
+high ADJ O
+sensitivity NOUN O
+cardiac ADJ O
+Troponin NOUN O
+- PUNCT O
+T PROPN O
+; PUNCT O
+MACE NOUN B-AC
+= PUNCT O
+major ADJ B-LF
+adverse ADJ I-LF
+cardiac ADJ I-LF
+events NOUN I-LF
+; PUNCT O
+ng NOUN O
+/ SYM O
+L NOUN O
+= PUNCT O
+nanograms NOUN O
+per ADP O
+liter NOUN O
+; PUNCT O
+OR NOUN O
+= PUNCT O
+odds NOUN O
+ratio NOUN O
+. PUNCT O
+
+Trabecular ADJ B-LF
+thickness NOUN I-LF
+( PUNCT O
+Tb NOUN B-AC
+. PUNCT B-AC
+Th NOUN B-AC
+; PUNCT O
+mm NOUN O
+) PUNCT O
+( PUNCT O
+Fig NOUN O
+2Ba NUM O
+) PUNCT O
+. PUNCT O
+
+DS PROPN B-AC
+, PUNCT O
+dorsal ADJ B-LF
+striatum NOUN I-LF
+; PUNCT O
+FR NOUN O
+, PUNCT O
+firing NOUN O
+rate NOUN O
+; PUNCT O
+OFC PROPN B-AC
+, PUNCT O
+orbitofrontal ADJ B-LF
+cortex NOUN I-LF
+; PUNCT O
+STE NOUN B-AC
+, PUNCT O
+standard ADJ B-LF
+error NOUN I-LF
+; PUNCT O
+VS NOUN B-AC
+, PUNCT O
+ventral ADJ B-LF
+striatum NOUN I-LF
+. PUNCT O
+
+CI PROPN B-AC
+, PUNCT O
+confidence NOUN B-LF
+interval NOUN I-LF
+; PUNCT O
+FF PROPN B-AC
+, PUNCT O
+fresh ADV B-LF
+frozen VERB I-LF
+; PUNCT O
+HR PROPN B-AC
+, PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+ICO PROPN B-AC
+, PUNCT O
+Catalan PROPN B-LF
+Institute PROPN I-LF
+of ADP I-LF
+Oncology PROPN I-LF
+; PUNCT O
+TCR PROPN B-AC
+, PUNCT O
+T NOUN B-LF
+- PUNCT I-LF
+cell NOUN I-LF
+receptor NOUN I-LF
+. PUNCT O
+
+In ADP O
+fully ADV O
+adjusted VERB O
+models NOUN O
+, PUNCT O
+the DET O
+As PROPN O
+- PUNCT O
+At+ PROPN O
+( PUNCT O
+β NOUN O
+= SYM O
+77.4 NUM O
+μm NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+[ PUNCT O
+CI NOUN B-AC
+] PUNCT O
+, PUNCT O
+10.3–144.5 NUM O
+μm NOUN O
+, PUNCT O
+p NOUN O
+= SYM O
+0.02 NUM O
+) PUNCT O
+and CCONJ O
+both DET O
+asthmatic ADJ O
+groups NOUN O
+, PUNCT O
+As+At- PROPN O
+( PUNCT O
+β NOUN O
+= SYM O
+64.2 NUM O
+μm NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+6.0–122.3 NUM O
+μm NOUN O
+, PUNCT O
+p NOUN O
+= SYM O
+0.03 NUM O
+) PUNCT O
+and CCONJ O
+As+At+ PROPN O
+( PUNCT O
+β NOUN O
+= SYM O
+85.8 NUM O
+μm NOUN O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+, PUNCT O
+24.2–147.4 NUM O
+μm NOUN O
+, PUNCT O
+p NOUN O
+= SYM O
+0.007 NUM O
+) PUNCT O
+had VERB O
+significantly ADV O
+thicker ADJ O
+RCB NOUN B-AC
+compared VERB O
+to ADP O
+the DET O
+As PROPN O
+- PUNCT O
+At- PROPN O
+participants NOUN O
+. PUNCT O
+
+Control ADJ O
+human ADJ O
+fibroblasts NOUN O
+were AUX O
+cultured VERB O
+for ADP O
+48 NUM O
+hours NOUN O
+on ADP O
+glass NOUN O
+coverslips NOUN O
+then ADV O
+treated VERB O
+with ADP O
+normal ADJ O
+growth NOUN O
+medium NOUN O
+or CCONJ O
+medium NOUN O
+containing VERB O
+2 NUM O
+μg NOUN O
+/ SYM O
+ml NOUN O
+brefeldin NOUN B-LF
+A PROPN I-LF
+( PUNCT O
+BFA PROPN B-AC
+) PUNCT O
+for ADP O
+120 NUM O
+seconds NOUN O
+. PUNCT O
+
+Every DET O
+year NOUN O
+worldwide ADV O
+, PUNCT O
+4.8 NUM O
+to ADP O
+15.3 NUM O
+per ADP O
+million NUM O
+persons NOUN O
+with ADP O
+autosomal ADJ B-LF
+dominant ADJ I-LF
+polycystic ADJ I-LF
+kidney NOUN I-LF
+disease NOUN I-LF
+( PUNCT O
+ADPKD PROPN B-AC
+) PUNCT O
+progress VERB O
+to ADP O
+end ADJ B-LF
+- ADJ I-LF
+stage NOUN I-LF
+renal ADJ I-LF
+disease NOUN I-LF
+( PUNCT O
+ESRD PROPN B-AC
+) PUNCT O
+[ PUNCT O
+1 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+homogenates NOUN O
+were AUX O
+used VERB O
+for ADP O
+the DET O
+estimation NOUN O
+of ADP O
+superoxide NOUN B-LF
+dismutase NOUN I-LF
+( PUNCT O
+SOD PROPN B-AC
+) PUNCT O
+, PUNCT O
+total ADJ O
+antioxidant ADJ O
+capacity NOUN O
+( PUNCT O
+MDA PROPN B-AC
+) PUNCT O
+, PUNCT O
+MCP1 PROPN B-AC
+, PUNCT O
+TNF PROPN O
+- PUNCT O
+α PROPN O
+, PUNCT O
+HSP70 PROPN B-AC
+, PUNCT O
+Bax PROPN B-AC
+, PUNCT O
+PLCγ PROPN B-AC
+and CCONJ O
+ERK1/2protein NOUN O
+expression NOUN O
+by ADP O
+enzyme NOUN B-LF
+- PUNCT I-LF
+linked VERB I-LF
+immunosorbent NOUN I-LF
+assay NOUN I-LF
+( PUNCT O
+ELISA PROPN B-AC
+) PUNCT O
+( PUNCT O
+R&D PROPN O
+Sys PROPN O
+. PUNCT O
+, PUNCT O
+USA PROPN O
+) PUNCT O
+according VERB O
+to ADP O
+the DET O
+manufacturer NOUN O
+’s PART O
+protocol NOUN O
+. PUNCT O
+
+Liver NOUN B-LF
+function NOUN I-LF
+tests NOUN I-LF
+( PUNCT O
+LFTs NOUN B-AC
+) PUNCT O
+are AUX O
+commonly ADV O
+used VERB O
+in ADP O
+clinic NOUN O
+approaching VERB O
+hepatobiliary ADJ O
+disease NOUN O
+. PUNCT O
+
+The DET O
+amino ADJ O
+acid NOUN O
+sequence NOUN O
+of ADP O
+Vibrio PROPN B-LF
+harveyi PROPN I-LF
+β NOUN I-LF
+- NOUN I-LF
+N NOUN I-LF
+- NOUN I-LF
+acetylglucosaminidase NOUN I-LF
+, PUNCT O
+VhGlcNAcase PROPN B-AC
+( PUNCT O
+SwissProt PROPN O
+: PUNCT O
+D9ISE0 PROPN O
+) PUNCT O
+was AUX O
+retrieved VERB O
+from ADP O
+the DET O
+Uniprot PROPN O
+database NOUN O
+. PUNCT O
+
+FS PROPN B-AC
+( PUNCT O
+50 NUM O
+μM NOUN O
+, PUNCT O
+5 NUM O
+min)-induced NOUN O
+phosphorylation NOUN O
+of ADP O
+CPEB3a PROPN O
+was AUX O
+prevented VERB O
+by ADP O
+pre NOUN O
+- PUNCT O
+treatment NOUN O
+with ADP O
+H89 NOUN O
+( PUNCT O
+10 NUM O
+μM NOUN O
+) PUNCT O
+or CCONJ O
+RP NOUN O
+- PUNCT O
+cAMPS NOUN O
+( PUNCT O
+100 NUM O
+μM NOUN O
+) PUNCT O
+. PUNCT O
+Treatment NOUN O
+with ADP O
+okadaic NOUN B-LF
+acid NOUN I-LF
+( PUNCT O
+OA PROPN B-AC
+) PUNCT O
+( PUNCT O
+0.3 NUM O
+μM NOUN O
+) PUNCT O
+, PUNCT O
+a DET O
+PP1 NOUN O
+/ SYM O
+PP2A PROPN O
+/ SYM O
+PP2B NOUN O
+inhibitor NOUN O
+[ PUNCT O
+43 NUM O
+] PUNCT O
+, PUNCT O
+led VERB O
+to ADP O
+a DET O
+significant ADJ O
+increase NOUN O
+in ADP O
+phosphorylated VERB O
+CPEB3 NOUN O
+, PUNCT O
+which PRON O
+was AUX O
+further ADV O
+increased VERB O
+when SCONJ O
+combined VERB O
+with ADP O
+FS PROPN B-AC
+treatment NOUN O
+( PUNCT O
+5 NUM O
+min NOUN O
+) PUNCT O
+( PUNCT O
+Fig PROPN O
+5C NUM O
+and CCONJ O
+5D NUM O
+, PUNCT O
+p<0.05 NUM O
+) PUNCT O
+. PUNCT O
+
+Random ADJ B-LF
+barcode NOUN I-LF
+transposon NOUN I-LF
+site NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT O
+RB PROPN B-AC
+- PUNCT B-AC
+TnSeq PROPN B-AC
+) PUNCT O
+allows VERB O
+genome NOUN O
+- PUNCT O
+wide ADJ O
+insertion NOUN O
+mutagenesis NOUN O
+leading VERB O
+to ADP O
+LOF PROPN B-AC
+mutations NOUN O
+[ PUNCT O
+64 NUM O
+] PUNCT O
+; PUNCT O
+a DET O
+pooled VERB O
+CRISPR NOUN B-LF
+interference NOUN I-LF
+( PUNCT O
+CRISPRi PROPN B-AC
+) PUNCT O
+approach NOUN O
+, PUNCT O
+which PRON O
+allows VERB O
+partial ADJ O
+inhibition NOUN O
+of ADP O
+gene NOUN O
+function NOUN O
+via ADP O
+transcriptional ADJ O
+inhibition NOUN O
+[ PUNCT O
+65 NUM O
+] PUNCT O
+; PUNCT O
+and CCONJ O
+dual ADJ B-LF
+- PUNCT I-LF
+barcoded ADJ I-LF
+shotgun NOUN I-LF
+expression NOUN I-LF
+library NOUN I-LF
+sequencing NOUN I-LF
+( PUNCT O
+Dub PROPN B-AC
+- PUNCT B-AC
+seq NOUN B-AC
+) PUNCT O
+[ PUNCT O
+66 NUM O
+] PUNCT O
+, PUNCT O
+which PRON O
+queries VERB O
+the DET O
+effects NOUN O
+of ADP O
+gene NOUN O
+overexpression NOUN O
+. PUNCT O
+
+The DET O
+vectors NOUN O
+of ADP O
+Aβ NOUN B-AC
+1–40 NUM O
+scrambled ADJ B-LF
+sequence NOUN O
+( PUNCT O
+SCR NOUN B-AC
+) PUNCT O
+and CCONJ O
+Aβ NOUN B-AC
+1–40 NUM O
+scrambled ADJ B-LF
+sequence NOUN O
+1–16 NUM O
+( PUNCT O
+NSCR PROPN B-AC
+) PUNCT O
+in ADP O
+pET-30a(+ NOUN O
+) PUNCT O
+were AUX O
+purchased VERB O
+from ADP O
+GenScript PROPN O
+and CCONJ O
+the DET O
+peptides NOUN O
+were AUX O
+expressed VERB O
+in ADP O
+Escherichia PROPN O
+coli NOUN O
+and CCONJ O
+then ADV O
+purified VERB O
+by ADP O
+HPLC PROPN O
+as SCONJ O
+described VERB O
+previously ADV O
+[ PUNCT O
+47 NUM O
+] PUNCT O
+. PUNCT O
+
+( PUNCT O
+A X O
+) PUNCT O
+Standard ADJ O
+histology NOUN O
+immunostaining NOUN O
+for ADP O
+high ADJ O
+molecular ADJ O
+weight NOUN O
+cytokeratins NOUN O
+and CCONJ O
+p63 NOUN O
+( PUNCT O
+basal ADJ O
+cell NOUN O
+markers NOUN O
+in ADP O
+brown ADJ O
+) PUNCT O
+and CCONJ O
+α NOUN O
+- PUNCT O
+methylacyl NOUN O
+- PUNCT O
+CoA NOUN O
+racemase NOUN O
+( PUNCT O
+cancer NOUN O
+cell NOUN O
+marker NOUN O
+in ADP O
+red ADJ O
+) PUNCT O
+, PUNCT O
+followed VERB O
+by ADP O
+hematoxylin NOUN B-LF
+and CCONJ I-LF
+eosin NOUN I-LF
+( PUNCT O
+H&E PROPN B-AC
+) PUNCT O
+counterstaining VERB O
+to PART O
+identify VERB O
+intraductal ADJ B-LF
+carcinoma NOUN I-LF
+of ADP I-LF
+the DET I-LF
+prostate NOUN I-LF
+( PUNCT O
+IDC PROPN B-AC
+- PUNCT B-AC
+P PROPN B-AC
+) PUNCT O
+along ADP O
+with ADP O
+adjacent ADJ O
+cancer NOUN O
+and CCONJ O
+prostate NOUN O
+cancer NOUN O
+without ADP O
+IDC PROPN B-AC
+- PUNCT B-AC
+P. PUNCT O
+
+Institutions NOUN O
+such ADJ O
+as ADP O
+the DET O
+World PROPN B-LF
+Health PROPN I-LF
+Organization PROPN I-LF
+( PUNCT O
+WHO PROPN B-AC
+) PUNCT O
+, PUNCT O
+United PROPN B-LF
+Nations PROPN I-LF
+International PROPN I-LF
+Children PROPN I-LF
+’s PART I-LF
+Emergency PROPN I-LF
+Fund PROPN I-LF
+( PUNCT O
+UNICEF PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+World PROPN O
+Bank PROPN O
+now ADV O
+advocate VERB O
+filling VERB O
+this DET O
+gap NOUN O
+via ADP O
+collection NOUN O
+and CCONJ O
+sharing NOUN O
+of ADP O
+program NOUN O
+cost NOUN O
+data NOUN O
+from ADP O
+evaluations NOUN O
+of ADP O
+ECD PROPN B-AC
+interventions NOUN O
+in ADP O
+LMIC PROPN B-AC
+settings NOUN O
+[ PUNCT O
+9 NUM O
+] PUNCT O
+. PUNCT O
+
+On ADP O
+multivariate ADJ O
+analysis NOUN O
+, PUNCT O
+≥2 NUM O
+TACE PROPN B-AC
+procedures NOUN O
+within ADP O
+6 NUM O
+months NOUN O
+( PUNCT O
+hazard NOUN B-LF
+ratio NOUN I-LF
+[ X O
+HR NOUN B-AC
+] X O
+= SYM O
+1.898 NUM O
+) PUNCT O
+, PUNCT O
+and CCONJ O
+the DET O
+des ADJ O
+- PUNCT O
+gamma NOUN O
+carboxyprothrombin NOUN O
+level NOUN O
+( PUNCT O
+HR NOUN B-AC
+= SYM O
+1.000 NUM O
+) PUNCT O
+independently ADV O
+predicted VERB O
+the DET O
+progression NOUN O
+to ADP O
+Barcelona PROPN B-LF
+Clinic PROPN I-LF
+Liver PROPN I-LF
+Cancer PROPN I-LF
+( PUNCT O
+BCLC PROPN B-AC
+) PUNCT O
+stage NOUN O
+C PROPN O
+in ADP O
+patients NOUN O
+with ADP O
+BCLC PROPN B-AC
+stage NOUN O
+0 NUM O
+- PUNCT O
+B NOUN O
+HCC PROPN B-AC
+( PUNCT O
+both PRON O
+P<0.05 NUM O
+) PUNCT O
+. PUNCT O
+
+Odds NOUN B-LF
+ratios NOUN I-LF
+( PUNCT O
+ORs NOUN B-AC
+) PUNCT O
+were AUX O
+estimated VERB O
+with ADP O
+logistic ADJ O
+regression NOUN O
+. PUNCT O
+
+* PUNCT O
+ROSC PROPN B-AC
+indicates VERB O
+return NOUN B-LF
+of ADP I-LF
+spontaneous ADJ I-LF
+circulation NOUN I-LF
+. PUNCT O
+
+Finally ADV O
+, PUNCT O
+our PRON O
+study NOUN O
+aims VERB O
+to PART O
+resolve VERB O
+conflicting VERB O
+evidence NOUN O
+on ADP O
+the DET O
+impact NOUN O
+of ADP O
+gender NOUN O
+, PUNCT O
+age NOUN O
+, PUNCT O
+body NOUN B-LF
+mass NOUN I-LF
+index NOUN I-LF
+( PUNCT O
+BMI PROPN B-AC
+) PUNCT O
+, PUNCT O
+daytime ADJ B-LF
+sleepiness NOUN I-LF
+( PUNCT O
+DS PROPN B-AC
+) PUNCT O
+, PUNCT O
+and CCONJ O
+comorbid ADJ O
+CV PROPN B-AC
+disease NOUN O
+on ADP O
+the DET O
+strength NOUN O
+of ADP O
+association NOUN O
+between ADP O
+OSA PROPN B-AC
+and CCONJ O
+development NOUN O
+of ADP O
+CV PROPN B-AC
+outcomes NOUN O
+. PUNCT O
+
+BMI PROPN B-AC
+= PUNCT O
+Body NOUN B-LF
+Mass NOUN I-LF
+Index NOUN I-LF
+, PUNCT O
+WC PROPN B-AC
+= PUNCT O
+Waist NOUN B-LF
+Circumference NOUN I-LF
+, PUNCT O
+BP NOUN O
+= PUNCT O
+Blood NOUN O
+Pressure NOUN O
+, PUNCT O
+Sys PROPN O
+= PUNCT O
+Systolic NOUN O
+, PUNCT O
+Dia NOUN O
+= PUNCT O
+Diastolic NOUN O
+, PUNCT O
+HbA1c NOUN B-AC
+= PUNCT O
+Glycated VERB B-LF
+Hemoglobin NOUN I-LF
+A1c NOUN O
+, PUNCT O
+FPG PROPN B-AC
+= PUNCT O
+Fasting NOUN B-LF
+Plasma NOUN I-LF
+Glucose NOUN I-LF
+, PUNCT O
+TC PROPN B-AC
+= PUNCT O
+Total ADJ B-LF
+Cholesterol NOUN I-LF
+, PUNCT O
+TG NOUN B-AC
+= PUNCT O
+Triglycerides NOUN B-LF
+, PUNCT O
+HDL PROPN B-AC
+- PUNCT B-AC
+Chol PROPN B-AC
+= PUNCT O
+High ADJ O
+Density NOUN O
+Liporpotein NOUN O
+Cholesterol NOUN O
+, PUNCT O
+LDL PROPN O
+- PUNCT O
+C PROPN O
+= PUNCT O
+Low ADJ O
+Density NOUN O
+Lipoprotein NOUN O
+Cholesterol NOUN O
+, PUNCT O
+LTL PROPN B-AC
+= PUNCT O
+Leukocyte NOUN B-LF
+Telomere PROPN I-LF
+Length PROPN I-LF
+, PUNCT O
+hTERT NOUN B-AC
+= PUNCT O
+Human PROPN B-LF
+Telomerase PROPN I-LF
+Reverse PROPN I-LF
+Transcriptase PROPN I-LF
+. PUNCT O
+
+Moreover ADV O
+their PRON O
+endocytic ADJ O
+capacities NOUN O
+make VERB O
+them PRON O
+effective ADJ O
+scavengers NOUN O
+for ADP O
+molecules NOUN O
+such ADJ O
+as ADP O
+albumin NOUN O
+, PUNCT O
+acetylated VERB B-LF
+low ADJ I-LF
+- NOUN I-LF
+density NOUN I-LF
+lipoproteins NOUN I-LF
+( PUNCT O
+Ac NOUN B-AC
+- NOUN B-AC
+LDL PROPN B-AC
+) PUNCT O
+and CCONJ O
+antigens NOUN O
+in ADP O
+the DET O
+bloodstream NOUN O
+[ PUNCT O
+1 NUM O
+, PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Discriminant PROPN B-LF
+Function PROPN I-LF
+Analysis PROPN I-LF
+( PUNCT O
+DFA PROPN B-AC
+) PUNCT O
+, PUNCT O
+also ADV O
+known VERB O
+as ADP O
+Linear PROPN B-LF
+Discriminant PROPN I-LF
+Analysis PROPN I-LF
+( PUNCT O
+LDA PROPN B-AC
+) PUNCT O
+, PUNCT O
+is AUX O
+a DET O
+statistical ADJ O
+analysis NOUN O
+which PRON O
+works VERB O
+to PART O
+attain VERB O
+the DET O
+maximum ADJ O
+discrimination NOUN O
+between ADP O
+classes NOUN O
+. PUNCT O
+
+C X B-AC
+- PUNCT B-AC
+statistic NOUN B-AC
+, PUNCT O
+concordance NOUN B-LF
+statistic NOUN I-LF
+. PUNCT O
+
+APR PROPN B-AC
+, PUNCT O
+apical ADJ B-LF
+polar ADJ I-LF
+ring NOUN I-LF
+; PUNCT O
+HA PROPN O
+, PUNCT O
+hemagglutinin NOUN O
+; PUNCT O
+SAS6L PROPN B-AC
+, PUNCT O
+SAS6 NOUN B-LF
+- PUNCT I-LF
+like ADJ I-LF
+. PUNCT O
+
+As ADP O
+a DET O
+consequence NOUN O
+of ADP O
+their PRON O
+dimer ADJ O
+polarity NOUN O
+, PUNCT O
+they PRON O
+contain VERB O
+plus ADJ O
+and CCONJ O
+minus ADJ O
+ends NOUN O
+, PUNCT O
+with ADP O
+plus ADJ O
+ends NOUN O
+representing VERB O
+the DET O
+growing NOUN O
+ends NOUN O
+that PRON O
+associate VERB O
+with ADP O
+microtubule NOUN O
+plus ADJ O
+- PUNCT O
+end NOUN O
+tracking NOUN O
+proteins NOUN O
+( PUNCT O
++ PUNCT O
+TIPs PROPN O
+) PUNCT O
+( PUNCT O
+end NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+protein NOUN I-LF
+3 NUM I-LF
+[ PUNCT O
+EB3 PROPN B-AC
+] PUNCT O
+, PUNCT O
+among ADP O
+others NOUN O
+) PUNCT O
+[ PUNCT O
+15 NUM O
+] PUNCT O
+. PUNCT O
+
+RA PROPN B-AC
+, PUNCT O
+robust ADJ B-LF
+nucleus NOUN I-LF
+of ADP I-LF
+the DET I-LF
+arcopallium NOUN I-LF
+. PUNCT O
+
+BSA PROPN B-AC
+, PUNCT O
+bovine ADJ B-LF
+serum NOUN I-LF
+albumin NOUN I-LF
+; PUNCT O
+Fc PROPN B-AC
+, PUNCT O
+fragment NOUN B-LF
+crystallizable ADJ I-LF
+; PUNCT O
+PMN PROPN B-AC
+, PUNCT O
+polymorphonuclear ADJ B-LF
+cell NOUN I-LF
+. PUNCT O
+
+In ADP O
+this DET O
+study NOUN O
+, PUNCT O
+we PRON O
+identified VERB O
+the DET O
+PY PROPN B-AC
+- ADJ B-AC
+NLS PROPN B-AC
+located VERB O
+in ADP O
+the DET O
+N NOUN O
+- ADJ O
+terminal ADJ O
+region NOUN O
+of ADP O
+Gli PROPN O
+proteins NOUN O
+as ADP O
+a DET O
+ciliary NOUN B-LF
+localization NOUN I-LF
+signal NOUN I-LF
+( PUNCT O
+CLS PROPN B-AC
+) PUNCT O
+whose DET O
+mutation NOUN O
+diminished VERB O
+Gli PROPN O
+ciliary NOUN O
+localization NOUN O
+. PUNCT O
+
+RR PROPN B-AC
+, PUNCT O
+risk NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+VL PROPN B-AC
+, PUNCT O
+viral ADJ B-LF
+load NOUN I-LF
+. PUNCT O
+
+GaTP PROPN B-AC
+: PUNCT O
+Gallium(III NOUN B-LF
+) PUNCT I-LF
+meso NOUN I-LF
+tetraphenylporphyrine NOUN I-LF
+chloride NOUN I-LF
+; PUNCT O
+GaNP PROPN B-AC
+: PUNCT O
+nanoparticle NOUN O
+encapsulating VERB O
+GaTP PROPN B-AC
+; PUNCT O
+GaF PROPN B-AC
+: PUNCT O
+folate NOUN O
+- PUNCT O
+conjugated VERB O
+nanoparticles NOUN O
+encapsulating VERB O
+GaTP PROPN B-AC
+; PUNCT O
+GaM PROPN B-AC
+: PUNCT O
+mannose NOUN O
+- PUNCT O
+conjugated VERB O
+nanoparticles NOUN O
+encapsulating VERB O
+GaTP PROPN B-AC
+; PUNCT O
+RifD PROPN B-AC
+: PUNCT O
+dendrimer NOUN O
+nanoparticle NOUN O
+encapsulating VERB O
+rifampin NOUN O
+; PUNCT O
+and CCONJ O
+RifNP PROPN O
+: PUNCT O
+P118 NOUN O
+nanoparticle NOUN O
+encapsulating VERB O
+rifampin NOUN O
+. PUNCT O
+
+Plastins NOUN O
+are AUX O
+a DET O
+family NOUN O
+of ADP O
+three NUM O
+tissue NOUN O
+- PUNCT O
+specific ADJ O
+actin NOUN B-LF
+- PUNCT I-LF
+binding VERB I-LF
+proteins NOUN I-LF
+( PUNCT O
+ABPs PROPN B-AC
+) PUNCT O
+. PUNCT O
+
+Delong PROPN O
+test NOUN O
+showed VERB O
+that SCONJ O
+the DET O
+combined VERB O
+model NOUN O
+had VERB O
+the DET O
+best ADJ O
+diagnostic ADJ O
+performance NOUN O
+: PUNCT O
+area NOUN B-LF
+under ADP I-LF
+the DET I-LF
+curve NOUN I-LF
+( PUNCT O
+AUC NOUN B-AC
+) PUNCT O
+, PUNCT O
+0.972 NUM O
+( PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+[ NUM O
+0.947–0.997 NUM O
+] PUNCT O
+) PUNCT O
+in ADP O
+the DET O
+training NOUN O
+cohort NOUN O
+and CCONJ O
+0.979 NUM O
+( PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+[ NUM O
+0.952–1 NUM O
+] PUNCT O
+) PUNCT O
+in ADP O
+the DET O
+validation NOUN O
+cohort NOUN O
+. PUNCT O
+
+Imaging NOUN O
+allows VERB O
+for ADP O
+differentiation NOUN O
+between ADP O
+hemorrhagic ADJ O
+and CCONJ O
+ischemic ADJ O
+stroke NOUN O
+, PUNCT O
+reveals VERB O
+extend NOUN O
+of ADP O
+the DET O
+ischemia NOUN O
+and CCONJ O
+allows VERB O
+reliable ADJ O
+patient NOUN O
+selection NOUN O
+for ADP O
+intra ADJ B-LF
+- PUNCT I-LF
+arterial ADJ I-LF
+therapy NOUN I-LF
+( PUNCT O
+IAT PROPN B-AC
+) PUNCT O
+treatment NOUN O
+( PUNCT O
+clot NOUN O
+formation NOUN O
+and CCONJ O
+location NOUN O
+, PUNCT O
+stenosis NOUN O
+and CCONJ O
+infarct NOUN O
+- PUNCT O
+area NOUN O
+) PUNCT O
+. PUNCT O
+[ X O
+3 X O
+] X O
+As SCONJ O
+IAT PROPN B-AC
+recently ADV O
+has AUX O
+been AUX O
+shown VERB O
+to PART O
+be AUX O
+beneficial ADJ O
+in ADP O
+acute ADJ O
+ischemic ADJ O
+stroke NOUN O
+caused VERB O
+by ADP O
+proximal ADJ O
+intracranial ADJ O
+anterior ADJ O
+circulation NOUN O
+occlusion NOUN O
+, PUNCT O
+the DET O
+role NOUN O
+of ADP O
+imaging NOUN O
+is AUX O
+even ADV O
+more ADV O
+essential ADJ O
+. PUNCT O
+[ X O
+4–8 X O
+] X O
+
+Chronic ADJ O
+obstructive ADJ O
+pulmonary ADJ O
+disease NOUN O
+= PUNCT O
+chronic ADJ O
+pulmonary ADJ O
+obstructive ADJ O
+disease NOUN O
+or CCONJ O
+bronchial ADJ O
+asthma NOUN O
+; PUNCT O
+IQR PROPN O
+= PUNCT O
+interquartile ADJ O
+range NOUN O
+; PUNCT O
+ICU PROPN B-AC
+= PUNCT O
+intensive ADJ B-LF
+care NOUN I-LF
+unit NOUN I-LF
+; PUNCT O
+BMI PROPN O
+= PUNCT O
+body NOUN O
+mass NOUN O
+index NOUN O
+; PUNCT O
+PaO2 PROPN O
+/ SYM O
+FiO2 PROPN O
+= PUNCT O
+arterial ADJ O
+pressure NOUN O
+of ADP O
+oxygen NOUN O
+/ SYM O
+fraction NOUN O
+of ADP O
+inspired VERB O
+oxygen NOUN O
+; PUNCT O
+Duration NOUN O
+of ADP O
+Mechanical ADJ O
+ventilation NOUN O
+= PUNCT O
+time NOUN O
+from ADP O
+intubation NOUN O
+to ADP O
+extubation NOUN O
+/ SYM O
+decannulation NOUN O
+or CCONJ O
+pressure NOUN O
+support NOUN O
+of ADP O
+or CCONJ O
+below ADP O
+5 NUM O
+cm NOUN O
+H2O NOUN O
+for ADP O
+at ADV O
+least ADV O
+24h NUM O
+; PUNCT O
+ECMO PROPN B-AC
+= PUNCT O
+extracorporeal ADJ B-LF
+membrane NOUN I-LF
+oxygenation NOUN I-LF
+; PUNCT O
+CVVHD PROPN O
+= PUNCT O
+continuous ADJ O
+venous ADJ O
+- PUNCT O
+venous ADJ O
+hemodialysis NOUN O
+
+G NOUN B-LF
+- PUNCT I-LF
+protein NOUN I-LF
+- PUNCT I-LF
+couple NOUN I-LF
+receptor NOUN I-LF
+, PUNCT I-LF
+family NOUN I-LF
+C PROPN I-LF
+, PUNCT I-LF
+group NOUN I-LF
+5 NUM I-LF
+member NOUN I-LF
+A PROPN I-LF
+( PUNCT O
+GPRC5A PROPN B-AC
+) PUNCT O
+, PUNCT O
+which PRON O
+was AUX O
+identified VERB O
+as ADP O
+an DET O
+all PRON O
+- PUNCT O
+trans ADJ O
+- PUNCT O
+retinoic ADJ O
+acid NOUN O
+- PUNCT O
+inducible ADJ O
+protein NOUN O
+, PUNCT O
+is AUX O
+a DET O
+member NOUN O
+of ADP O
+class NOUN O
+c NUM O
+orphan NOUN O
+GPCRs PROPN B-AC
+. PUNCT O
+GPRC5A PROPN B-AC
+, PUNCT O
+also ADV O
+known VERB O
+as ADP O
+RAI3 PROPN B-AC
+or CCONJ O
+RAIG1 PROPN B-AC
+, PUNCT O
+can AUX O
+activate VERB O
+numerous ADJ O
+signal NOUN O
+transduction NOUN O
+cascades NOUN O
+, PUNCT O
+including VERB O
+the DET O
+NF PROPN O
+- PUNCT O
+κB PROPN O
+, PUNCT O
+cAMP PROPN O
+- PUNCT O
+Gs PROPN O
+α PROPN O
+, PUNCT O
+FAK PROPN O
+/ SYM O
+Scr PROPN O
+, PUNCT O
+and CCONJ O
+STAT3 PROPN O
+signaling NOUN O
+pathways NOUN O
+[ PUNCT O
+5 NUM O
+] PUNCT O
+. PUNCT O
+
+Cobalt NOUN B-LF
+( PUNCT I-LF
+III NUM I-LF
+) PUNCT I-LF
+protoporphyrin NOUN I-LF
+- PUNCT I-LF
+IX NOUN I-LF
+- PUNCT I-LF
+chloride NOUN I-LF
+( PUNCT O
+CoPP PROPN B-AC
+) PUNCT O
+or CCONJ O
+tin NOUN O
+protoporphyrin NOUN O
+- PUNCT O
+IX NOUN O
+( PUNCT O
+SnPP)-treated PROPN B-AC
+BM PROPN B-AC
+- PUNCT B-AC
+DCs NOUN B-AC
+from ADP O
+BALB PROPN O
+/ X O
+c NOUN O
+mice NOUN O
+were AUX O
+stimulated VERB O
+with ADP O
+or CCONJ O
+without ADP O
+LPS PROPN O
+( PUNCT O
+1 NUM O
+μg NOUN O
+/ X O
+ml NOUN O
+) PUNCT O
+for ADP O
+24 NUM O
+hours NOUN O
+. PUNCT O
+
+SD NOUN B-AC
+: PUNCT O
+standard ADJ B-LF
+deviation NOUN I-LF
+
+ASO PROPN B-AC
+01–15 NUM O
+targets VERB O
+the DET O
+exonic ADJ O
+portion NOUN O
+of ADP O
+the DET O
+3′ NUM O
+splice NOUN O
+site NOUN O
+, PUNCT O
+whereas SCONJ O
+ASOs NOUN B-AC
+11–25 NUM O
+, PUNCT O
+16–30 NUM O
+, PUNCT O
+21–35 NUM O
+, PUNCT O
+and CCONJ O
+26–40 NUM O
+target VERB O
+a DET O
+central ADJ O
+region NOUN O
+that PRON O
+comprises VERB O
+a DET O
+transformer NOUN B-LF
+2 NUM I-LF
+beta NOUN I-LF
+1 NUM I-LF
+protein NOUN I-LF
+( PUNCT O
+Tra2β1)-binding NOUN B-AC
+motif NOUN O
+in ADP O
+SMN PROPN B-AC
+exon NOUN O
+7 NUM O
+[ PUNCT O
+38 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+adjusted VERB B-LF
+hazard NOUN I-LF
+ratios NOUN I-LF
+( PUNCT O
+aHRs NOUN B-AC
+) PUNCT O
+and CCONJ O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+intervals NOUN I-LF
+( PUNCT O
+CIs NOUN B-AC
+) PUNCT O
+and CCONJ O
+98 NUM O
+% NOUN O
+CIs NOUN B-AC
+of ADP O
+incident NOUN O
+fragility NOUN O
+fracture NOUN O
+and CCONJ O
+osteoporosis NOUN O
+/ SYM O
+fragility NOUN O
+fracture NOUN O
+were AUX O
+estimated VERB O
+using VERB O
+the DET O
+multivariable ADJ O
+Cox PROPN O
+proportional ADJ O
+hazard NOUN O
+model NOUN O
+after ADP O
+adjusting VERB O
+for ADP O
+age NOUN O
+, PUNCT O
+sex NOUN O
+, PUNCT O
+occupation NOUN O
+, PUNCT O
+drug NOUN O
+use NOUN O
+, PUNCT O
+and CCONJ O
+comorbidities NOUN O
+. PUNCT O
+
+Note VERB O
+that SCONJ O
+TPGmax NOUN O
+and CCONJ O
+TPGmean NOUN O
+are AUX O
+estimated VERB O
+based VERB O
+on ADP O
+the DET O
+equation NOUN O
+for ADP O
+the DET O
+transvalvular ADJ B-LF
+pressure NOUN I-LF
+gradient NOUN I-LF
+( PUNCT O
+TPG NOUN B-AC
+= SYM O
+4 NUM O
+× SYM O
+velcoity2 NOUN O
+) PUNCT O
+. PUNCT O
+
+Previous ADJ O
+studies NOUN O
+have AUX O
+emphasized VERB O
+that SCONJ O
+drivers NOUN O
+of ADP O
+high ADJ O
+- PUNCT O
+order NOUN O
+thalamic ADJ O
+nuclei NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+the DET O
+MD PROPN B-AC
+or CCONJ O
+the DET O
+ventral ADJ B-LF
+anterior ADJ I-LF
+nucleus NOUN I-LF
+( PUNCT O
+VA PROPN B-AC
+) PUNCT O
+, PUNCT O
+originate VERB O
+from ADP O
+large ADJ O
+layer NOUN O
+5 NUM O
+cortical ADJ O
+neurons NOUN O
+( PUNCT O
+e.g. X O
+, PUNCT O
+[ X O
+22,24,36 NUM O
+] PUNCT O
+; PUNCT O
+reviewed VERB O
+in ADP O
+[ X O
+37,38 NUM O
+] PUNCT O
+) PUNCT O
+. PUNCT O
+
+Front ADJ B-LF
+- PUNCT I-LF
+of ADP I-LF
+- PUNCT I-LF
+pack NOUN I-LF
+( PUNCT O
+FOP PROPN B-AC
+) PUNCT O
+nutrition NOUN O
+labels NOUN O
+have AUX O
+received VERB O
+growing VERB O
+attention NOUN O
+from ADP O
+policy NOUN O
+makers NOUN O
+worldwide ADV O
+, PUNCT O
+as SCONJ O
+they PRON O
+are AUX O
+considered VERB O
+promising ADJ O
+tools NOUN O
+in ADP O
+public ADJ O
+health NOUN O
+nutrition NOUN O
+[ PUNCT O
+1,2 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+lethality NOUN O
+can AUX O
+be AUX O
+rescued VERB O
+by ADP O
+concurrent ADJ O
+knockout NOUN O
+of ADP O
+interferon NOUN B-LF
+induced VERB I-LF
+with ADP I-LF
+helicase PROPN I-LF
+C PROPN I-LF
+domain NOUN I-LF
+1 NUM I-LF
+( PUNCT O
+IFIH1 PROPN B-AC
+, PUNCT O
+also ADV O
+called VERB O
+MDA5 PROPN O
+) PUNCT O
+, PUNCT O
+a DET O
+cytosolic ADJ O
+sensor NOUN O
+that PRON O
+recognizes VERB O
+viral ADJ O
+dsRNA NOUN B-AC
+and CCONJ O
+induces VERB O
+the DET O
+type NOUN O
+I NUM O
+IFN PROPN B-AC
+- PUNCT O
+mediated VERB O
+antiviral ADJ O
+immunity NOUN O
+[ X O
+25,26 NUM O
+] PUNCT O
+. PUNCT O
+
+HD NOUN B-AC
+, PUNCT O
+high ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+Pf PROPN B-AC
+infection NOUN O
+; PUNCT O
+LD PROPN B-AC
+, PUNCT O
+low ADJ B-LF
+- PUNCT I-LF
+density NOUN I-LF
+Pf PROPN B-AC
+infection NOUN O
+; PUNCT O
+RR NOUN B-AC
+, PUNCT O
+risk NOUN B-LF
+ratio NOUN I-LF
+; PUNCT O
+RRadj PROPN O
+, PUNCT O
+adjusted VERB O
+RR NOUN B-AC
+. PUNCT O
+sd NOUN O
+- PUNCT O
+mRDT NOUN B-AC
+, PUNCT O
+standard ADJ O
+malaria NOUN O
+RDT NOUN O
+; PUNCT O
+us PROPN O
+- PUNCT O
+qPCR PROPN B-AC
+, PUNCT O
+quantitative ADJ O
+PCR NOUN O
+. PUNCT O
+
+ART PROPN B-AC
+, PUNCT O
+antiretroviral ADJ B-LF
+therapy NOUN I-LF
+; PUNCT O
+HIV PROPN O
+- PUNCT O
+ve PROPN O
+, PUNCT O
+HIV PROPN O
+negative ADJ O
+; PUNCT O
+SOC PROPN B-AC
+, PUNCT O
+standard NOUN B-LF
+of ADP I-LF
+care NOUN I-LF
+; PUNCT O
+ST PROPN O
+, PUNCT O
+self NOUN O
+- PUNCT O
+test NOUN O
+; PUNCT O
+VMMC PROPN B-AC
+, PUNCT O
+voluntary ADJ B-LF
+medical ADJ I-LF
+male ADJ I-LF
+circumcision NOUN I-LF
+. PUNCT O
+
+Anti ADJ O
+- PUNCT O
+miR-17 NOUN B-AC
+- PUNCT B-AC
+5p NOUN B-AC
+also ADV O
+lowered VERB O
+luciferase NOUN O
+activities NOUN O
+of ADP O
+constructs NOUN O
+harboring VERB O
+four NUM O
+out ADP O
+of ADP O
+six NUM O
+PTEN PROPN B-AC
+3’UTR NOUN O
+binding VERB O
+sites NOUN O
+predicted VERB O
+for ADP O
+miR-17 NOUN B-AC
+- PUNCT B-AC
+3p NOUN B-AC
+( PUNCT O
+Fig NOUN O
+13B NUM O
+) PUNCT O
+. PUNCT O
+These DET O
+results NOUN O
+implied VERB O
+that SCONJ O
+artificial ADJ O
+anti ADJ O
+- PUNCT O
+miR-17 NOUN B-AC
+- PUNCT B-AC
+5p NOUN B-AC
+DNA NOUN O
+- PUNCT O
+LNA NOUN B-AC
+against ADP O
+miR-17 NOUN B-AC
+- PUNCT B-AC
+5p NOUN B-AC
+guide NOUN O
+strand NOUN O
+could AUX O
+exert VERB O
+functions NOUN O
+of ADP O
+an DET O
+miRNA NOUN B-AC
+by ADP O
+mimicking VERB O
+the DET O
+passenger NOUN B-LF
+strand NOUN I-LF
+of ADP I-LF
+miR-17 NOUN I-LF
+- PUNCT B-AC
+5p NOUN B-AC
+, PUNCT O
+and CCONJ O
+could AUX O
+interact VERB O
+with ADP O
+some PRON O
+of ADP O
+the DET O
+miR-17 NOUN B-AC
+- PUNCT B-AC
+3p NOUN B-AC
+binding VERB O
+sites NOUN O
+in ADP O
+the DET O
+3’UTR NOUN O
+of ADP O
+PDCD4 PROPN B-AC
+and CCONJ O
+PTEN PROPN B-AC
+mRNAs NOUN O
+. PUNCT O
+
+We PRON O
+found VERB O
+that SCONJ O
+the DET O
+pharmacological ADJ O
+inhibition NOUN O
+of ADP O
+p65 NOUN O
+NF PROPN B-AC
+- NOUN B-AC
+κB NOUN B-AC
+activation NOUN O
+via ADP O
+the DET O
+specific ADJ O
+inhibitor NOUN O
+caffeic ADJ B-LF
+acid NOUN I-LF
+phenethyl NOUN I-LF
+ester NOUN I-LF
+( PUNCT O
+CAPE PROPN B-AC
+) PUNCT O
+did AUX O
+not PART O
+affect VERB O
+the DET O
+increased VERB O
+activity NOUN O
+of ADP O
+p38 NOUN O
+MAPK NOUN B-AC
+or CCONJ O
+PKCζ NOUN B-AC
+caused VERB O
+by ADP O
+CCL20 PROPN B-AC
+overexpression NOUN O
+( PUNCT O
+Fig NOUN O
+5B NUM O
+, PUNCT O
+S5A NOUN O
+Fig NOUN O
+) PUNCT O
+, PUNCT O
+which PRON O
+suggested VERB O
+that SCONJ O
+p65 NOUN O
+probably ADV O
+was AUX O
+the DET O
+downstream ADJ O
+effector NOUN O
+of ADP O
+p38 NOUN O
+MAPK NOUN B-AC
+or CCONJ O
+PKCζ NOUN B-AC
+when SCONJ O
+transducing VERB O
+CCL20 PROPN B-AC
+stimuli NOUN O
+. PUNCT O
+
+CHA2DS2 PROPN B-AC
+- PUNCT B-AC
+VASc PROPN B-AC
+, PUNCT O
+Congestive ADJ B-LF
+heart NOUN I-LF
+failure NOUN I-LF
+, PUNCT I-LF
+Hypertension NOUN I-LF
+, PUNCT I-LF
+Age NOUN I-LF
+≥ SYM I-LF
+75 NUM I-LF
+years NOUN I-LF
+, PUNCT I-LF
+Diabetes NOUN I-LF
+, PUNCT I-LF
+previous ADJ I-LF
+Stroke NOUN I-LF
+, PUNCT I-LF
+Vascular ADJ I-LF
+disease NOUN I-LF
+, PUNCT I-LF
+Age NOUN I-LF
+65–74 NUM I-LF
+years NOUN I-LF
+, PUNCT I-LF
+Sex NOUN I-LF
+category NOUN I-LF
+. PUNCT O
+
+PCell PROPN B-AC
+, PUNCT O
+pyramidal ADJ B-LF
+cell NOUN I-LF
+. PUNCT O
+
+VPP PROPN B-AC
+: PUNCT O
+valine NOUN B-LF
+– SYM I-LF
+proline NOUN I-LF
+– SYM I-LF
+proline NOUN I-LF
+. PUNCT O
+
+Therefore ADV O
+, PUNCT O
+it PRON O
+is AUX O
+crucial ADJ O
+to PART O
+determine VERB O
+the DET O
+post ADJ B-LF
+- ADJ I-LF
+mortem ADJ I-LF
+interval NOUN I-LF
+( PUNCT O
+PMI NOUN B-AC
+) PUNCT O
+as ADP O
+precisely ADV O
+as ADP O
+possible ADJ O
+. PUNCT O
+
+Concomitantly ADV O
+, PUNCT O
+the DET O
+Talin PROPN O
+concentration NOUN O
+at ADP O
+attachment NOUN O
+sites NOUN O
+increases VERB O
+5 ADV O
+- ADV O
+fold ADV O
+as SCONJ O
+quantified VERB O
+by ADP O
+fluorescence NOUN B-LF
+correlation NOUN I-LF
+spectroscopy NOUN I-LF
+( PUNCT O
+FCS PROPN B-AC
+) PUNCT O
+, PUNCT O
+suggesting VERB O
+that SCONJ O
+only ADV O
+a DET O
+small ADJ O
+proportion NOUN O
+of ADP O
+Talin PROPN O
+molecules NOUN O
+are AUX O
+mechanically ADV O
+engaged VERB O
+at ADP O
+any DET O
+given VERB O
+time NOUN O
+. PUNCT O
+
+The DET O
+control NOUN O
+of ADP O
+PMk PROPN B-AC
+was AUX O
+represented VERB O
+as ADP O
+the DET O
+root NOUN B-LF
+- PUNCT I-LF
+mean NOUN I-LF
+- PUNCT I-LF
+square NOUN I-LF
+( PUNCT O
+RMS PROPN B-AC
+) PUNCT O
+of ADP O
+the DET O
+PAk PROPN B-AC
+time NOUN O
+- PUNCT O
+series NOUN O
+with ADP O
+respect NOUN O
+to ADP O
+trial NOUN O
+duration NOUN O
+( PUNCT O
+t NOUN O
+) PUNCT O
+( PUNCT O
+PAkRMS PROPN O
+) PUNCT O
+( PUNCT O
+Eq NOUN O
+1 NUM O
+) PUNCT O
+. PUNCT O
+
+Non PROPN B-LF
+- PUNCT I-LF
+Invasive PROPN I-LF
+Ventilation PROPN I-LF
+( PUNCT O
+NIV PROPN B-AC
+) PUNCT O
+reduces VERB O
+in ADP O
+- PUNCT O
+hospital NOUN O
+mortality NOUN O
+in ADP O
+selected VERB O
+patients NOUN O
+with ADP O
+acute ADJ B-LF
+respiratory ADJ I-LF
+failure NOUN I-LF
+( PUNCT O
+ARF PROPN B-AC
+) PUNCT O
+[ X O
+1–4 NUM O
+] PUNCT O
+. PUNCT O
+
+Then ADV O
+, PUNCT O
+these DET O
+binomial ADJ O
+pulses NOUN O
+were AUX O
+tested VERB O
+in ADP O
+combination NOUN O
+with ADP O
+the DET O
+“ PUNCT O
+Sum PROPN B-LF
+- PUNCT I-LF
+Of ADP I-LF
+- PUNCT I-LF
+Square PROPN I-LF
+” PUNCT O
+( PUNCT O
+SOS PROPN B-AC
+) PUNCT O
+technique NOUN O
+, PUNCT O
+in ADP O
+order NOUN O
+to PART O
+suppress VERB O
+banding NOUN O
+artifacts NOUN O
+. PUNCT O
+
+We PRON O
+found VERB O
+that SCONJ O
+the DET O
+presence NOUN O
+of ADP O
+ctDNA NOUN B-AC
+at ADP O
+baseline NOUN O
+was AUX O
+an DET O
+independent ADJ O
+marker NOUN O
+of ADP O
+poor ADJ O
+prognosis NOUN O
+, PUNCT O
+with ADP O
+a DET O
+median ADJ O
+overall ADJ O
+survival NOUN O
+of ADP O
+13.6 NUM O
+versus ADP O
+21.5 NUM O
+mo NOUN O
+( PUNCT O
+adjusted VERB O
+hazard NOUN B-LF
+ratio NOUN I-LF
+[ X O
+HR NOUN B-AC
+] X O
+1.82 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.01–3.55 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.045 NUM O
+) PUNCT O
+and CCONJ O
+a DET O
+median ADJ O
+progression NOUN O
+- PUNCT O
+free ADJ O
+survival NOUN O
+of ADP O
+4.9 NUM O
+versus ADP O
+10.4 NUM O
+mo NOUN O
+( PUNCT O
+adjusted VERB O
+HR NOUN B-AC
+2.14 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN O
+1.30–3.67 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.002 NUM O
+) PUNCT O
+. PUNCT O
+
+In ADP O
+2005 NUM O
+, PUNCT O
+the DET O
+Yellow PROPN O
+Fever PROPN O
+Initiative PROPN O
+— PUNCT O
+a DET O
+collaboration NOUN O
+between ADP O
+the DET O
+World PROPN O
+Health PROPN O
+Organization PROPN O
+( PUNCT O
+WHO PROPN O
+) PUNCT O
+and CCONJ O
+the DET O
+United PROPN O
+Nations PROPN O
+Children PROPN O
+Fund PROPN O
+supported VERB O
+by ADP O
+the DET O
+Global PROPN B-LF
+Alliance PROPN I-LF
+for ADP I-LF
+Vaccines PROPN I-LF
+and CCONJ I-LF
+Immunization PROPN I-LF
+( PUNCT O
+GAVI PROPN B-AC
+Alliance)—was PROPN O
+launched VERB O
+to PART O
+create VERB O
+a DET O
+vaccine NOUN O
+stockpile NOUN O
+for ADP O
+use NOUN O
+in ADP O
+epidemics NOUN O
+and CCONJ O
+to PART O
+implement VERB O
+preventive ADJ O
+mass NOUN O
+vaccination NOUN O
+campaigns NOUN O
+in ADP O
+the DET O
+12 NUM O
+most ADV O
+affected VERB O
+countries NOUN O
+in ADP O
+West PROPN O
+Africa PROPN O
+. PUNCT O
+
+The DET O
+ventilation NOUN B-LF
+rate NOUN I-LF
+( PUNCT O
+VR NOUN B-AC
+) PUNCT O
+could AUX O
+be AUX O
+set VERB O
+by ADP O
+altering VERB O
+the DET O
+motor NOUN O
+voltage NOUN O
+. PUNCT O
+
+A DET O
+Cochrane PROPN O
+systematic ADJ O
+review NOUN O
+suggests VERB O
+that SCONJ O
+multi ADJ O
+- ADJ O
+faceted ADJ O
+interventions NOUN O
+are AUX O
+the DET O
+best ADJ O
+way NOUN O
+to PART O
+reduce VERB O
+inappropriate ADJ O
+prescriptions NOUN O
+[ X O
+8 NUM O
+] PUNCT O
+in ADP O
+combining VERB O
+educational ADJ O
+interventions NOUN O
+for ADP O
+General PROPN B-LF
+Practitioners PROPN I-LF
+( PUNCT O
+GPs PROPN B-AC
+) PUNCT O
+and CCONJ O
+practical ADJ O
+tools NOUN O
+easily ADV O
+usable ADJ O
+in ADP O
+primary ADJ O
+care NOUN O
+[ X O
+9,10 NUM O
+] PUNCT O
+. PUNCT O
+
+Among ADP O
+patients NOUN O
+with ADP O
+stage NOUN O
+II NUM O
+esophageal ADJ O
+cancer NOUN O
+, PUNCT O
+definitive ADJ O
+CCRT PROPN B-AC
+was AUX O
+associated VERB O
+with ADP O
+a DET O
+significantly ADV O
+higher ADJ O
+recurrence NOUN O
+rate NOUN O
+relative ADJ O
+to ADP O
+surgery NOUN O
+with ADP O
+combined VERB O
+therapy NOUN O
+( PUNCT O
+odd ADJ O
+ratios NOUN O
+[ PUNCT O
+OR NOUN B-AC
+] PUNCT O
+: PUNCT O
+1.46 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+confidence NOUN B-LF
+interval NOUN I-LF
+[ PUNCT O
+CI NOUN B-AC
+] PUNCT O
+: PUNCT O
+1.07–1.98 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.018 NUM O
+) PUNCT O
+, PUNCT O
+although SCONJ O
+no DET O
+significant ADJ O
+difference NOUN O
+was AUX O
+observed VERB O
+among ADP O
+patients NOUN O
+with ADP O
+stage NOUN O
+III NUM O
+disease NOUN O
+( PUNCT O
+OR NOUN B-AC
+: PUNCT O
+1.21 NUM O
+, PUNCT O
+95 NUM O
+% NOUN O
+CI NOUN B-AC
+: PUNCT O
+0.90–1.64 NUM O
+, PUNCT O
+p NOUN O
+= SYM O
+0.214 NUM O
+) PUNCT O
+( PUNCT O
+Table PROPN O
+4 NUM O
+) PUNCT O
+. PUNCT O
+
+PVI PROPN B-AC
+was AUX O
+performed VERB O
+in ADP O
+all DET O
+studies NOUN O
+and CCONJ O
+an DET O
+additional ADJ O
+linear ADJ O
+or CCONJ O
+complex ADJ B-LF
+fractionated ADJ I-LF
+atrial ADJ I-LF
+electrogram NOUN I-LF
+( PUNCT O
+CFAE PROPN B-AC
+) PUNCT O
+ablation NOUN O
+was AUX O
+performed VERB O
+in ADP O
+4 NUM O
+studies NOUN O
+. PUNCT O
+
+However ADV O
+, PUNCT O
+the DET O
+expressions NOUN O
+of ADP O
+epithelial ADJ B-LF
+- NOUN I-LF
+mesenchymal ADJ I-LF
+transition NOUN I-LF
+( PUNCT O
+EMT PROPN B-AC
+) PUNCT O
+marker NOUN O
+genes NOUN O
+, PUNCT O
+such ADJ O
+as ADP O
+N NOUN O
+- NOUN O
+cadherin NOUN O
+and CCONJ O
+E NOUN O
+- NOUN O
+cadherin NOUN O
+, PUNCT O
+were AUX O
+not PART O
+changed VERB O
+in ADP O
+the DET O
+kidneys NOUN O
+after ADP O
+UUO PROPN B-AC
+. PUNCT O
+Masson PROPN O
+’s PART O
+trichrome NOUN O
+staining NOUN O
+and CCONJ O
+fluorescence NOUN O
+immunostaining NOUN O
+showed VERB O
+that SCONJ O
+piceatannol NOUN O
+administration NOUN O
+attenuated VERB O
+collagen NOUN O
+deposition NOUN O
+in ADP O
+UUO PROPN B-AC
+kidneys NOUN O
+. PUNCT O
+
+The DET O
+human ADJ O
+upper ADJ B-LF
+respiratory ADJ I-LF
+tract NOUN I-LF
+( PUNCT O
+URT PROPN B-AC
+) PUNCT O
+is AUX O
+repeatedly ADV O
+exposed VERB O
+to ADP O
+a DET O
+large ADJ O
+variety NOUN O
+of ADP O
+inhaled VERB O
+microbes NOUN O
+; PUNCT O
+accordingly ADV O
+, PUNCT O
+upper ADJ B-LF
+respiratory ADJ I-LF
+tract NOUN I-LF
+infections NOUN I-LF
+( PUNCT O
+URTI PROPN B-AC
+) PUNCT O
+constitute VERB O
+the DET O
+most ADV O
+common ADJ O
+reason NOUN O
+for ADP O
+emergency NOUN O
+room NOUN O
+visits NOUN O
+in ADP O
+primary ADJ O
+health NOUN O
+care NOUN O
+[ PUNCT O
+1 NUM O
+, PUNCT O
+2 NUM O
+] PUNCT O
+. PUNCT O
+
+Please INTJ O
+add VERB O
+the DET O
+following ADJ O
+statement NOUN O
+, PUNCT O
+or CCONJ O
+similar ADJ O
+, PUNCT O
+to ADP O
+the DET O
+Methods NOUN O
+: PUNCT O
+" PUNCT O
+This DET O
+study NOUN O
+is AUX O
+reported VERB O
+as ADP O
+per ADP O
+the DET O
+Strengthening VERB B-LF
+the DET I-LF
+Reporting PROPN I-LF
+of ADP I-LF
+Observational PROPN I-LF
+Studies PROPN I-LF
+in ADP I-LF
+Epidemiology PROPN I-LF
+( PUNCT O
+STROBE PROPN B-AC
+) PUNCT O
+guideline NOUN O
+( PUNCT O
+S1 PROPN O
+Checklist PROPN O
+) PUNCT O
+. PUNCT O
+" PUNCT O
+The DET O
+STROBE PROPN B-AC
+guideline NOUN O
+can AUX O
+be AUX O
+found VERB O
+here ADV O
+: PUNCT O
+http://www.equator-network.org/reporting-guidelines/strobe/ X O
+
+Higher ADJ O
+levels NOUN O
+of ADP O
+glucose NOUN B-LF
+infusion NOUN I-LF
+rate NOUN I-LF
+( PUNCT O
+GIR PROPN B-AC
+) PUNCT O
+were AUX O
+found VERB O
+in ADP O
+the DET O
+UA PROPN B-AC
+- PUNCT O
+treated VERB O
+mice NOUN O
+than ADP O
+controls NOUN O
+during ADP O
+the DET O
+clamp NOUN O
+( PUNCT O
+Fig PROPN O
+1 NUM O
+M NUM O
+) PUNCT O
+. PUNCT O
+This DET O
+increase NOUN O
+in ADP O
+GIR PROPN B-AC
+was AUX O
+caused VERB O
+by ADP O
+elevated ADJ O
+whole ADJ O
+- PUNCT O
+body NOUN O
+glucose NOUN O
+uptake NOUN O
+as ADP O
+well ADV O
+as ADP O
+the DET O
+decreased VERB O
+endogenous ADJ O
+hepatic ADJ O
+glucose NOUN O
+production NOUN O
+during ADP O
+the DET O
+clamp NOUN O
+( PUNCT O
+Fig PROPN O
+1N NUM O
+and CCONJ O
+1O NUM O
+) PUNCT O
+. PUNCT O
+Consistently ADV O
+, PUNCT O
+UA PROPN B-AC
+- PUNCT O
+treated VERB O
+mice NOUN O
+showed VERB O
+higher ADJ O
+levels NOUN O
+of ADP O
+insulin NOUN O
+- PUNCT O
+stimulated VERB O
+glucose NOUN O
+uptake NOUN O
+in ADP O
+gastrocnemius NOUN O
+muscle NOUN O
+, PUNCT O
+BAT PROPN B-AC
+, PUNCT O
+and CCONJ O
+WAT PROPN B-AC
+than ADP O
+controls NOUN O
+during ADP O
+the DET O
+clamp NOUN O
+( PUNCT O
+Fig PROPN O
+1P NUM O
+) PUNCT O
+. PUNCT O
+Note VERB O
+that SCONJ O
+similar ADJ O
+levels NOUN O
+of ADP O
+glucose NOUN O
+were AUX O
+observed VERB O
+between ADP O
+control NOUN O
+and CCONJ O
+UA PROPN B-AC
+- PUNCT O
+treated VERB O
+mice NOUN O
+under ADP O
+normal ADJ O
+diet NOUN O
+feeding NOUN O
+( PUNCT O
+S1E PROPN O
+Fig PROPN O
+) PUNCT O
+, PUNCT O
+consistent ADJ O
+with ADP O
+their PRON O
+comparable ADJ O
+body NOUN O
+weight NOUN O
+. PUNCT O
+
+Participants NOUN O
+were AUX O
+from ADP O
+the DET O
+‘ PUNCT O
+Change NOUN B-LF
+in ADP I-LF
+alcohol NOUN I-LF
+outlet NOUN I-LF
+density NOUN I-LF
+and CCONJ I-LF
+alcohol NOUN I-LF
+- PUNCT I-LF
+related VERB I-LF
+harm NOUN I-LF
+to ADP I-LF
+population NOUN I-LF
+health NOUN I-LF
+’ PUNCT O
+( PUNCT O
+CHALICE PROPN B-AC
+) PUNCT O
+study NOUN O
+[ PUNCT O
+10 NUM O
+] PUNCT O
+. PUNCT O
+
+The DET O
+mice NOUN O
+were AUX O
+killed VERB O
+in ADP O
+humane ADJ O
+fashion NOUN O
+via ADP O
+CO2 NOUN O
+asphyxiation NOUN O
+and CCONJ O
+cervical ADJ O
+dislocation NOUN O
+according VERB O
+to ADP O
+the DET O
+American PROPN B-LF
+Veterinary PROPN I-LF
+Medical PROPN I-LF
+Association PROPN I-LF
+( PUNCT O
+AVMA PROPN B-AC
+) PUNCT O
+Guidelines PROPN O
+. PUNCT O
+
+Somatic ADJ O
+embryogenesis NOUN O
+( PUNCT O
+number NOUN O
+/ SYM O
+g NOUN O
+FW NOUN B-AC
+): PUNCT O
+Number NOUN O
+of ADP O
+somatic ADJ O
+embryogenesis NOUN O
+/ SYM O
+fresh ADJ B-LF
+weight NOUN I-LF
+of ADP O
+initial ADJ O
+inoculation NOUN O
+during ADP O
+pre NOUN O
+- NOUN O
+culture NOUN O
+
+DALY PROPN B-AC
+, PUNCT O
+disability NOUN B-LF
+- PUNCT I-LF
+adjusted VERB I-LF
+life NOUN I-LF
+year NOUN I-LF
+; PUNCT O
+NMB PROPN O
+, PUNCT O
+net ADJ O
+monetary ADJ O
+benefit NOUN O
+; PUNCT O
+PMC PROPN B-AC
+, PUNCT O
+polyvalent ADJ B-LF
+meningococcal NOUN I-LF
+conjugate NOUN I-LF
+; PUNCT O
+PMP PROPN B-AC
+, PUNCT O
+polyvalent ADJ B-LF
+meningococcal NOUN I-LF
+polysaccharide NOUN I-LF
+. PUNCT O
+