Within ADP O
amoebae NOUN O
and CCONJ O
macrophages NOUN O
, PUNCT O
L. PROPN O
pneumophila PROPN O
replicates VERB O
with ADP O
a DET O
similar ADJ O
mechanism NOUN O
by ADP O
forming VERB O
a DET O
membrane NOUN O
- PUNCT O
bound VERB O
compartment NOUN O
, PUNCT O
the DET O
Legionella PROPN O
- PUNCT O
containing VERB O
vacuole NOUN O
( PUNCT O
LCV PROPN B-AC
) PUNCT O
. PUNCT O
Formation NOUN O
of ADP O
the DET O
LCV PROPN B-AC
is AUX O
not PART O
well ADV O
defined VERB O
, PUNCT O
but CCONJ O
requires VERB O
that SCONJ O
L. PROPN O
pneumophila PROPN O
injects VERB O
proteins NOUN O
into ADP O
the DET O
host NOUN O
cell NOUN O
via ADP O
the DET O
intracellular ADJ B-LF
multiplication NOUN I-LF
( PUNCT O
Icm)/defective ADJ B-LF
organelle NOUN I-LF
trafficking NOUN I-LF
( PUNCT O
Dot NOUN B-AC
) PUNCT O
secretion NOUN O
system NOUN O
. PUNCT O

L NOUN O
16 NUM O
: PUNCT O
Would AUX O
contraceptive ADJ B-LF
prevalence NOUN I-LF
rate NOUN I-LF
( PUNCT O
CPR NOUN B-AC
) PUNCT O
or CCONJ O
even ADV O
modern ADJ O
CPR NOUN B-AC
( PUNCT O
mCPR NOUN O
) PUNCT O
be AUX O
more ADV O
appropriate ADJ O
? PUNCT O

Stable ADJ O
metabolically ADV B-LF
unhealthy ADJ I-LF
overweight NOUN I-LF
or CCONJ I-LF
obesity NOUN I-LF
( PUNCT O
MUOO PROPN B-AC
) PUNCT O
( PUNCT O
HR NOUN B-AC
2.22 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ X O
CI NOUN B-AC
] X O
2.00–2.47 NUM O
, PUNCT O
p NOUN O
< ADP O
0.001 NUM O
) PUNCT O
and CCONJ O
transition NOUN O
from ADP O
metabolically ADV O
healthy ADJ O
to ADP O
unhealthy ADJ O
status NOUN O
( PUNCT O
HR NOUN B-AC
1.53 NUM O
, PUNCT O
1.34–1.75 NUM O
, PUNCT O
p NOUN O
< ADP O
0.001 NUM O
) PUNCT O
were AUX O
associated VERB O
with ADP O
higher ADJ O
risk NOUN O
for ADP O
MVE PROPN B-AC
, PUNCT O
compared VERB O
with ADP O
stable ADJ O
healthy ADJ O
normal ADJ O
weight NOUN O
. PUNCT O

At ADP O
present NOUN O
, PUNCT O
many ADJ O
disease NOUN O
- PUNCT O
surveillance NOUN O
systems NOUN O
rely VERB O
either CCONJ O
on ADP O
comparing VERB O
current ADJ O
counts NOUN O
with ADP O
historical ADJ O
time NOUN O
- PUNCT O
series NOUN O
models NOUN O
, PUNCT O
or CCONJ O
on ADP O
identifying VERB O
sudden ADJ O
increases NOUN O
in ADP O
utilization NOUN O
( PUNCT O
e.g. X O
, PUNCT O
cumulative ADJ B-LF
sum NOUN I-LF
[ X O
CUSUM X B-AC
] PUNCT O
or CCONJ O
exponential ADJ B-LF
weighted VERB I-LF
moving VERB I-LF
average NOUN I-LF
[ X O
EWMA PROPN B-AC
] PUNCT O
[ X O
9,10 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

Also ADV O
see VERB O
Fig PROPN O
4 NUM O
. PUNCT O
dpIns1 NOUN O
, PUNCT O
dorsal ADJ O
posterior ADJ O
insula NOUN O
cluster NOUN O
1 NUM O
; PUNCT O
PO1 NOUN B-AC
, PUNCT O
parietal ADJ B-LF
operculum NOUN I-LF
cluster NOUN I-LF
1 NUM I-LF
; PUNCT O
STG1 NOUN O
, PUNCT O
superior ADJ O
temporal ADJ O
gyrus NOUN O
cluster NOUN O
1 NUM O
. PUNCT O

In ADP O
C. PROPN O
elegans NOUN O
, PUNCT O
the DET O
prevailing VERB O
response NOUN O
to ADP O
mitochondrial ADJ O
stress NOUN O
is AUX O
the DET O
mitochondrial ADJ B-LF
unfolded VERB I-LF
protein NOUN I-LF
response NOUN I-LF
( PUNCT O
UPRmt NOUN B-AC
) PUNCT O
[ X O
16–19 NUM O
] PUNCT O
. PUNCT O

The DET O
principal ADJ O
catabolic ADJ O
fate NOUN O
of ADP O
cholesterol NOUN O
is AUX O
its PRON O
conversion NOUN O
to ADP O
the DET O
primary ADJ O
bile NOUN B-LF
acids NOUN I-LF
( PUNCT O
BAs PROPN B-AC
) PUNCT O
, PUNCT O
cholic NOUN B-LF
acid NOUN I-LF
( PUNCT O
CA PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
chenodeoxycholic NOUN B-LF
acid NOUN I-LF
( PUNCT O
CDCA NOUN B-AC
) PUNCT O
through ADP O
BBB NOUN B-AC
- PUNCT O
permeable ADJ O
intermediate ADJ O
metabolites NOUN O
called VERB O
oxysterols NOUN O
( PUNCT O
S1 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

We PRON O
performed VERB O
one NUM O
- ADJ O
way NOUN O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
( PUNCT O
ANOVA NOUN B-AC
) PUNCT O
with ADP O
Tukey PROPN O
's PART O
HSD NOUN O
post ADJ O
- ADJ O
hoc ADJ O
test VERB O
to PART O
test VERB O
the DET O
significance NOUN O
in ADP O
comparisons NOUN O
with ADP O
more ADJ O
than ADP O
2 NUM O
groups NOUN O
. PUNCT O

The DET O
types NOUN O
of ADP O
variability NOUN O
responsiveness NOUN O
tested VERB O
were AUX O
SL PROPN B-AC
variability NOUN O
and CCONJ O
MTC PROPN B-AC
variability NOUN O
using VERB O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD PROPN B-AC
) PUNCT O
and CCONJ O
CV NOUN B-AC
, PUNCT O
and CCONJ O
SBS PROPN B-AC
- PUNCT B-AC
FTA NOUN B-AC
variability NOUN O
. PUNCT O

We PRON O
then ADV O
investigated VERB O
the DET O
DIP2A PROPN B-AC
expression NOUN O
pattern NOUN O
in ADP O
the DET O
adult ADJ O
cortex NOUN O
with ADP O
Dip2a NOUN B-LF
- NOUN I-LF
β NOUN I-LF
- NOUN I-LF
galactosidase NOUN I-LF
( PUNCT O
LacZ PROPN B-AC
) PUNCT O
mice NOUN O
, PUNCT O
in ADP O
which PRON O
LacZ PROPN B-AC
was AUX O
designed VERB O
with ADP O
nucleus NOUN O
expression NOUN O
[ PUNCT O
22 NUM O
] PUNCT O
. PUNCT O

The DET O
47 NUM O
- PUNCT O
item NOUN O
PMH PROPN B-AC
instrument NOUN O
consists VERB O
of ADP O
six NUM O
domains NOUN O
of ADP O
mental ADJ O
health NOUN O
; PUNCT O
general ADJ B-LF
coping NOUN I-LF
( PUNCT O
GC PROPN B-AC
, PUNCT O
9 NUM O
items NOUN O
) PUNCT O
, PUNCT O
emotional ADJ B-LF
support NOUN I-LF
( PUNCT O
ES PROPN B-AC
, PUNCT O
7 NUM O
items NOUN O
) PUNCT O
, PUNCT O
spirituality NOUN O
( PUNCT O
7 NUM O
items NOUN O
) PUNCT O
, PUNCT O
interpersonal ADJ B-LF
skills NOUN I-LF
( PUNCT O
IS PROPN B-AC
, PUNCT O
9 NUM O
items NOUN O
) PUNCT O
, PUNCT O
personal ADJ B-LF
growth NOUN I-LF
and CCONJ I-LF
autonomy NOUN I-LF
( PUNCT O
PGA PROPN B-AC
, PUNCT O
10 NUM O
items NOUN O
) PUNCT O
and CCONJ O
global ADJ B-LF
affect NOUN I-LF
( PUNCT O
GA PROPN B-AC
, PUNCT O
5 NUM O
items NOUN O
) PUNCT O
[ PUNCT O
14 NUM O
] PUNCT O
. PUNCT O

Preliminary ADJ O
results NOUN O
show VERB O
that SCONJ O
a DET O
tax NOUN O
levied VERB O
on ADP O
sugar NOUN B-LF
- PUNCT I-LF
sweetened VERB I-LF
beverages NOUN I-LF
( PUNCT O
SSBs PROPN B-AC
) PUNCT O
by ADP O
the DET O
Portuguese ADJ O
government NOUN O
in ADP O
2017 NUM O
led VERB O
to ADP O
a DET O
drop NOUN O
in ADP O
sales NOUN O
and CCONJ O
reformulation NOUN O
of ADP O
these DET O
products NOUN O
. PUNCT O

TB NOUN B-AC
, PUNCT O
tuberculosis NOUN B-LF
; PUNCT O
TST NOUN B-AC
, PUNCT O
tuberculin NOUN B-LF
skin NOUN I-LF
testing NOUN I-LF
. PUNCT O

LOS PROPN B-AC
= PUNCT O
late ADJ O
onset NOUN O
sepsis NOUN O
, PUNCT O
NEC PROPN B-AC
= PUNCT O
necrotizing VERB B-LF
enterocolitis NOUN I-LF

The DET O
data NOUN O
of ADP O
the DET O
ENMERE-2016 PROPN B-AC
( PUNCT O
Peruvian PROPN B-LF
Medical PROPN I-LF
Residents PROPN I-LF
National PROPN I-LF
Survey-2016 PROPN I-LF
) PUNCT O
belongs VERB O
to ADP O
the DET O
National PROPN O
Committee PROPN O
of ADP O
Peruvian PROPN O
Medical PROPN O
Residency PROPN O
. PUNCT O

In ADP O
order NOUN O
to PART O
understand VERB O
how SCONJ O
p84 NOUN O
could AUX O
mask VERB O
Ser582 PROPN O
phosphorylation NOUN O
, PUNCT O
and CCONJ O
to PART O
map VERB O
the DET O
p110γ NOUN O
- PUNCT O
p84 NOUN O
contact NOUN O
interface NOUN O
, PUNCT O
hydrogen NOUN B-LF
deuterium NOUN I-LF
exchange NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT O
HDX NOUN B-AC
- PUNCT B-AC
MS PROPN B-AC
) PUNCT O
was AUX O
used VERB O
. PUNCT O

FPG PROPN B-AC
, PUNCT O
fasting VERB B-LF
plasma NOUN I-LF
glucose NOUN I-LF
; PUNCT O
TNFi PROPN B-AC
, PUNCT O
tumour NOUN O
necrosis NOUN O
factor NOUN O
inhibitor NOUN O
. PUNCT O

Among ADP O
HNSCCs PROPN O
, PUNCT O
oral ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinomas NOUN I-LF
( PUNCT O
OSCCs PROPN B-AC
) PUNCT O
include VERB O
several ADJ O
anatomical ADJ O
locations NOUN O
of ADP O
the DET O
oral ADJ O
cavity NOUN O
, PUNCT O
but CCONJ O
exclude VERB O
the DET O
oropharynx NOUN O
. PUNCT O

We PRON O
then ADV O
did VERB O
the DET O
reverse ADJ O
experiment NOUN O
, PUNCT O
i.e. X O
, PUNCT O
we PRON O
coexpressed VERB O
wild ADJ B-LF
type NOUN I-LF
( PUNCT O
WT PROPN B-AC
) PUNCT O
STAT1 PROPN O
and CCONJ O
mutant ADJ O
STAT2 PROPN O
that PRON O
harbored VERB O
alanine NOUN O
in ADP O
the DET O
STAT1 PROPN O
F77 PROPN O
homologous ADJ O
position NOUN O
leucine NOUN O
82 NUM O
( PUNCT O
Fig PROPN O
1B NOUN O
, PUNCT O
panels NOUN O
11 NUM O
and CCONJ O
12 NUM O
) PUNCT O
or CCONJ O
the DET O
functionally ADV O
equivalent ADJ O
double ADJ O
mutation NOUN O
LL81,82AA NUM O
( PUNCT O
S3 PROPN O
Fig PROPN O
) PUNCT O
. PUNCT O

The DET O
finding NOUN O
of ADP O
an DET O
overall ADJ O
rise NOUN O
in ADP O
opioid NOUN O
prescribing NOUN O
is AUX O
complementary ADJ O
to ADP O
a DET O
recent ADJ O
study NOUN O
using VERB O
National PROPN B-LF
Health PROPN I-LF
Service PROPN I-LF
( PUNCT O
NHS PROPN B-AC
) PUNCT O
digital ADJ O
pharmacy NOUN O
claims NOUN O
data NOUN O
demonstrating VERB O
a DET O
34 NUM O
% NOUN O
increase NOUN O
in ADP O
opioid NOUN O
prescriptions NOUN O
between ADP O
1998 NUM O
and CCONJ O
2016 NUM O
[ PUNCT O
7 NUM O
] PUNCT O
. PUNCT O

In ADP O
most ADJ O
patients NOUN O
, PUNCT O
preoperative ADJ O
levels NOUN O
of ADP O
serum ADJ O
follicle NOUN B-LF
- PUNCT I-LF
stimulating VERB I-LF
hormone NOUN I-LF
( PUNCT O
FSH PROPN B-AC
) PUNCT O
, PUNCT O
leutenizing VERB B-LF
hormone NOUN I-LF
( PUNCT O
LH PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
total ADJ O
testosterone NOUN O
were AUX O
measured VERB O
. PUNCT O

Lgl PROPN B-AC
binds VERB O
to PART O
atypical ADJ B-LF
protein NOUN I-LF
kinase NOUN I-LF
C PROPN I-LF
( PUNCT O
aPKC PROPN B-AC
) PUNCT O
and CCONJ O
Par6 PROPN O
, PUNCT O
and CCONJ O
this DET O
interaction NOUN O
has AUX O
been AUX O
shown VERB O
to PART O
regulate VERB O
the DET O
function NOUN O
of ADP O
Lgl PROPN B-AC
in ADP O
cell NOUN O
polarity NOUN O
[ PUNCT O
14],[15],[16 NUM O
] PUNCT O
. PUNCT O

IPTp PROPN B-AC
- PUNCT O
SP PROPN B-AC
has AUX O
been AUX O
shown VERB O
to PART O
reduce VERB O
low ADJ B-LF
birth NOUN I-LF
weight NOUN I-LF
( PUNCT O
LBW PROPN B-AC
) PUNCT O
deliveries NOUN O
and CCONJ O
maternal ADJ O
morbidity NOUN O
[ PUNCT O
1],[9 NUM O
] PUNCT O
. PUNCT O

A NOUN O
) PUNCT O
When SCONJ O
compared VERB O
to ADP O
their PRON O
control NOUN O
( PUNCT O
CypD+/+ PROPN B-AC
) PUNCT O
littermates NOUN O
, PUNCT O
BMSCs NOUN B-AC
from ADP O
CypD-/- PROPN B-AC
mice NOUN O
have VERB O
higher ADJ O
oxidative ADJ O
metabolism NOUN O
measured VERB O
with ADP O
both CCONJ O
CMXRos PROPN O
( PUNCT O
A NOUN O
) PUNCT O
and CCONJ O
via ADP O
oxygen NOUN B-LF
consumption NOUN I-LF
rate NOUN I-LF
( PUNCT O
OCR PROPN B-AC
) PUNCT O
assay NOUN O
using VERB O
Seahorse PROPN O
XF PROPN O
technology NOUN O
( PUNCT O
B NOUN O
) PUNCT O
; PUNCT O
C X O
) PUNCT O
X NOUN O
- ADJ O
ray NOUN O
and CCONJ O
micro ADJ B-AC
- ADJ B-AC
CT ADJ B-AC
images NOUN O
of ADP O
spinal ADJ O
grafts NOUN O
at ADP O
D0 NOUN O
and CCONJ O
at ADP O
12 NUM O
wks NOUN O
post ADJ O
- ADJ O
surgery NOUN O
. PUNCT O

For ADP O
example NOUN O
, PUNCT O
oxylipins NOUN O
, PUNCT O
such ADJ O
as ADP O
prostaglandins NOUN O
, PUNCT O
including VERB O
prostaglandin NOUN B-LF
E2 PROPN I-LF
( PUNCT O
PGE2 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
leukotrienes NOUN O
play VERB O
a DET O
pivotal ADJ O
role NOUN O
in ADP O
the DET O
inflammatory ADJ O
response NOUN O
[ PUNCT O
12,13 NUM O
] PUNCT O
. PUNCT O

By ADP O
searching VERB O
a DET O
database NOUN O
of ADP O
pathogen NOUN O
proteins NOUN O
, PUNCT O
the DET O
researchers NOUN O
discovered VERB O
that SCONJ O
rotavirus NOUN O
protein NOUN O
VP-7 NOUN O
contains VERB O
a DET O
very ADV O
similar ADJ O
peptide NOUN O
; PUNCT O
a DET O
search NOUN O
of ADP O
a DET O
database NOUN O
of ADP O
human ADJ O
proteins NOUN O
indicated VERB O
that SCONJ O
celiac ADJ O
peptide NOUN O
also ADV O
resembles VERB O
peptides NOUN O
found VERB O
in ADP O
tissue NOUN O
transglutaminase NOUN O
, PUNCT O
Toll PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
4 NUM I-LF
( PUNCT O
TLR4 PROPN B-AC
; PUNCT O
a DET O
protein NOUN O
involved VERB O
in ADP O
the DET O
innate ADJ O
immune ADJ O
response NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
several ADJ O
other ADJ O
self NOUN O
- PUNCT O
antigens NOUN O
. PUNCT O

Confocal ADJ O
microscopy NOUN O
analysis NOUN O
of ADP O
adoptively ADV O
transferred VERB O
TCR PROPN O
- NOUN O
transgenic ADJ O
CD8 PROPN O
+ NOUN O
T PROPN O
cells NOUN O
( PUNCT O
Spiky PROPN O
) PUNCT O
in ADP O
LNs PROPN B-AC
performed VERB O
on ADP O
day NOUN O
2 NUM O
post NOUN O
immunization NOUN O
with ADP O
DC PROPN B-AC
- NOUN O
targeting VERB O
viral ADJ O
particles NOUN O
. PUNCT O
( PUNCT O
E NOUN O
) PUNCT O
Zoom VERB O
- NOUN O
in ADP O
panels NOUN O
of ADP O
the DET O
area NOUN O
indicated VERB O
by ADP O
rectangle NOUN O
in ADP O
( PUNCT O
D NOUN O
) PUNCT O
. PUNCT O
Scale NOUN O
bars NOUN O
represent VERB O
30 NUM O
μm NOUN O
( PUNCT O
D NOUN O
) PUNCT O
and CCONJ O
10 NUM O
μm NOUN O
( PUNCT O
E NOUN O
) PUNCT O
. PUNCT O
Data NOUN O
represent VERB O
mean ADJ O
± ADJ O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean ADJ I-LF
( PUNCT O
SEM PROPN B-AC
) PUNCT O
for ADP O
6–20 NUM O
mice NOUN O
per ADP O
group NOUN O
from ADP O
three NUM O
independent ADJ O
experiments NOUN O
( PUNCT O
A NOUN O
– PUNCT O
B NOUN O
) PUNCT O
. PUNCT O
Data NOUN O
represent VERB O
mean ADJ O
± ADJ O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT O
SD NOUN B-AC
) PUNCT O
for ADP O
5–10 NUM O
datasets NOUN O
from ADP O
2–3 NUM O
mice NOUN O
per ADP O
group NOUN O
from ADP O
two NUM O
independent ADJ O
experiments NOUN O
( PUNCT O
C NOUN O
) PUNCT O
. PUNCT O
* PUNCT O
p NOUN O
< ADP O
0.05 NUM O
, PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< ADP O
0.01 NUM O
, PUNCT O
* PUNCT O
* PUNCT O
* PUNCT O
p NOUN O
< ADP O
0.001 NUM O
( PUNCT O
one NUM O
- NOUN O
way NOUN O
ANOVA NOUN O
with ADP O
Tukey PROPN O
’s PART O
post NOUN O
- NOUN O
test NOUN O
[ X O
A NOUN O
– PUNCT O
B NOUN O
] PUNCT O
or CCONJ O
Kruskal PROPN O
- NOUN O
Wallis PROPN O
test NOUN O
with ADP O
Dunn PROPN O
’s PART O
post NOUN O
- NOUN O
test NOUN O
[ X O
C NOUN O
] PUNCT O
) PUNCT O
. PUNCT O
ns NOUN O
, PUNCT O
not PART O
significant ADJ O
. PUNCT O

The DET O
neurotoxin NOUN O
6 NUM B-AC
- PUNCT B-AC
OHDA NOUN B-AC
is AUX O
selectively ADV O
transported VERB O
via ADP O
the DET O
dopamine NOUN B-LF
transporter NOUN I-LF
( PUNCT O
DAT PROPN B-AC
) PUNCT O
. PUNCT O
We PRON O
compared VERB O
toxicity NOUN O
of ADP O
6 NUM B-AC
- PUNCT B-AC
OHDA NOUN B-AC
in ADP O
purified ADJ O
and CCONJ O
unpurified ADJ O
N27 PROPN O
cells NOUN O
. PUNCT O

GFP PROPN B-AC
, PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT O

BD NOUN B-AC
, PUNCT O
birth NOUN B-LF
defect NOUN I-LF
. PUNCT O

We PRON O
compared VERB O
the DET O
tumor NOUN O
cells NOUN O
and CCONJ O
the DET O
patient NOUN O
's PART O
peripheral ADJ O
blood NOUN O
cells NOUN O
by ADP O
fluorescent ADJ O
in ADP O
situ NOUN O
hybridization NOUN O
using VERB O
X NOUN O
and CCONJ O
Y NOUN O
chromosome NOUN O
probes NOUN O
, PUNCT O
by ADP O
PCR NOUN O
for ADP O
the DET O
amelogenin NOUN O
gene NOUN O
X- NOUN O
and CCONJ O
Y NOUN O
- PUNCT O
specific ADJ O
alleles NOUN O
, PUNCT O
by ADP O
MassArray PROPN O
for ADP O
the DET O
ATM PROPN O
patient NOUN O
specific ADJ O
mutation NOUN O
and CCONJ O
for ADP O
several ADJ O
SNPs NOUN O
, PUNCT O
by ADP O
PCR NOUN O
for ADP O
polymorphic ADJ O
microsatellites NOUN O
, PUNCT O
and CCONJ O
by ADP O
human ADJ B-LF
leukocyte NOUN I-LF
antigen NOUN I-LF
( PUNCT O
HLA PROPN B-AC
) PUNCT O
typing NOUN O
. PUNCT O

The DET O
Area PROPN B-LF
Under ADP I-LF
the DET I-LF
Curve PROPN I-LF
( PUNCT O
AUC PROPN B-AC
) PUNCT O
, PUNCT O
sensitivity NOUN O
, PUNCT O
specificity NOUN O
, PUNCT O
along ADP O
with ADP O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT O
PPV NOUN B-AC
) PUNCT O
and CCONJ O
negative ADJ O
predicting VERB O
value NOUN O
( PUNCT O
NPV NOUN B-AC
) PUNCT O
and CCONJ O
p NOUN O
value NOUN O
were AUX O
determined VERB O
. PUNCT O

For ADP O
Ontario PROPN O
residents NOUN O
with ADP O
diagnosed VERB O
OSA PROPN B-AC
, PUNCT O
funding NOUN O
is AUX O
provided VERB O
for ADP O
continuous ADJ B-LF
positive ADJ I-LF
airway NOUN I-LF
pressure NOUN I-LF
( PUNCT O
CPAP PROPN B-AC
) PUNCT O
devices NOUN O
, PUNCT O
and CCONJ O
this DET O
funding NOUN O
is AUX O
documented VERB O
in ADP O
the DET O
Assistive PROPN B-LF
Devices PROPN I-LF
Program PROPN I-LF
( PUNCT O
ADP PROPN B-AC
) PUNCT O
database NOUN O
from ADP O
2004 NUM O
onwards ADV O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

There PRON O
are VERB O
two NUM O
genome NOUN O
- PUNCT O
wide ADJ O
approaches NOUN O
to PART O
identify VERB O
novel ADJ O
imprinted VERB O
genes NOUN O
in ADP O
mammals NOUN O
: PUNCT O
quantification NOUN O
of ADP O
parent NOUN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
origin NOUN I-LF
differential ADJ I-LF
allelic ADJ I-LF
expression NOUN I-LF
( PUNCT O
pDAE PROPN B-AC
) PUNCT O
to PART O
identify VERB O
monoallelic ADJ O
expression NOUN O
directly ADV O
from ADP O
the DET O
transcripts NOUN O
, PUNCT O
or CCONJ O
identification NOUN O
of ADP O
parent NOUN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
origin NOUN I-LF
dependent ADJ I-LF
differentially ADV I-LF
methylated VERB I-LF
regions NOUN I-LF
( PUNCT O
pDMRs PROPN B-AC
) PUNCT O
in ADP O
the DET O
genome NOUN O
. PUNCT O

Based VERB O
on ADP O
these DET O
data NOUN O
, PUNCT O
we PRON O
estimated VERB O
instantaneous ADJ B-LF
carboxylation NOUN I-LF
efficiency NOUN I-LF
( PUNCT O
PN NOUN B-AC
/ SYM B-AC
Ci NOUN B-AC
) PUNCT O
and CCONJ O
instantaneous ADJ B-LF
water NOUN I-LF
use NOUN I-LF
efficiency NOUN I-LF
( PUNCT O
WUE NOUN B-AC
, PUNCT O
( PUNCT O
μmol NOUN O
m-2 NOUN O
s-1)/(mmol NOUN O
H2O NOUN O
m-2 NOUN O
s-1 NOUN O
) PUNCT O
) PUNCT O
, PUNCT O
as ADP O
the DET O
ratio NOUN O
PN NOUN B-AC
/ SYM O
E NOUN O
[ PUNCT O
28 NUM O
] PUNCT O
. PUNCT O

The DET O
reduction NOUN O
in ADP O
the DET O
rate NOUN O
of ADP O
YLL PROPN B-AC
calculated VERB O
based VERB O
on ADP O
the DET O
age NOUN O
- PUNCT O
standardized VERB O
deaths NOUN O
shows VERB O
that SCONJ O
most ADJ O
causes NOUN O
of ADP O
death NOUN O
have AUX O
registered VERB O
a DET O
fall NOUN O
in ADP O
rate NOUN O
of ADP O
years NOUN B-LF
of ADP I-LF
life NOUN I-LF
lost VERB I-LF
from ADP O
1990 NUM O
to ADP O
2015 NUM O
. PUNCT O

Outcomes NOUN O
: PUNCT O
acid NOUN B-LF
- PUNCT I-LF
fast ADJ I-LF
bacilli NOUN I-LF
( PUNCT O
AFB PROPN B-AC
) PUNCT O
smear NOUN O
microscopy NOUN O
( PUNCT O
smear NOUN O
) PUNCT O
and CCONJ O
culture NOUN O
conversion NOUN O
, PUNCT O
adverse ADJ O
events NOUN O
, PUNCT O
and CCONJ O
WHO PROPN B-AC
- PUNCT O
defined VERB O
treatment NOUN O
outcomes NOUN O
, PUNCT O
including VERB O
cure NOUN O
, PUNCT O
treatment NOUN O
completion NOUN O
, PUNCT O
treatment NOUN O
failure NOUN O
, PUNCT O
loss NOUN O
to PART O
follow VERB O
- PUNCT O
up ADP O
, PUNCT O
not PART O
evaluated VERB O
, PUNCT O
and CCONJ O
death NOUN O
( PUNCT O
see VERB O
Table NOUN O
1 NUM O
for ADP O
definitions NOUN O
) PUNCT O
[ PUNCT O
7 NUM O
] PUNCT O
. PUNCT O

Acute ADJ O
cellular ADJ O
rejection NOUN O
and CCONJ O
interstitial ADJ B-LF
fibrosis NOUN I-LF
and CCONJ I-LF
tubular ADJ I-LF
atrophy NOUN I-LF
( PUNCT O
IF NOUN B-AC
/ SYM B-AC
TA NOUN B-AC
) PUNCT O
index NOUN O
were AUX O
graded VERB O
according VERB O
to ADP O
the DET O
Banff’13 PROPN O
criteria NOUN O
[ PUNCT O
21 NUM O
] PUNCT O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
MHN PROPN B-AC
, PUNCT O
metabolically ADV B-LF
healthy ADJ I-LF
normal ADJ I-LF
weight NOUN I-LF
; PUNCT O
MHOO PROPN B-AC
, PUNCT O
metabolically ADV B-LF
healthy ADJ I-LF
overweight NOUN I-LF
or CCONJ I-LF
obesity NOUN I-LF
; PUNCT O
MUN PROPN B-AC
, PUNCT O
metabolically ADV B-LF
unhealthy ADJ I-LF
normal ADJ I-LF
weight NOUN I-LF
; PUNCT O
MUOO PROPN B-AC
, PUNCT O
metabolically ADV B-LF
unhealthy ADJ I-LF
overweight NOUN I-LF
or CCONJ I-LF
obesity NOUN I-LF
. PUNCT O

CC PROPN B-AC
, PUNCT O
corpus NOUN B-LF
callosum NOUN I-LF
; PUNCT O
DTI PROPN B-AC
, PUNCT O
diffusion NOUN B-LF
tensor NOUN I-LF
imaging NOUN I-LF
; PUNCT O
EC PROPN B-AC
, PUNCT O
external ADJ B-LF
capsule NOUN I-LF
; PUNCT O
EM PROPN B-AC
, PUNCT O
electron NOUN B-LF
microscopy NOUN I-LF
; PUNCT O
IL-4 NOUN B-AC
, PUNCT O
interleukin-4 NOUN B-LF
; PUNCT O
LSD PROPN B-AC
, PUNCT O
least ADJ B-LF
significant ADJ I-LF
difference NOUN I-LF
; PUNCT O
MCAO PROPN B-AC
, PUNCT O
middle ADJ B-LF
cerebral ADJ I-LF
artery NOUN I-LF
occlusion NOUN I-LF
. PUNCT O

Each DET O
record NOUN O
in ADP O
the DET O
census NOUN O
data NOUN O
had VERB O
information NOUN O
on ADP O
the DET O
census NOUN O
enumeration NOUN B-LF
area NOUN I-LF
( PUNCT O
EA PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
smallest ADJ O
geographical ADJ O
unit NOUN O
, PUNCT O
with ADP O
an DET O
average ADJ O
population NOUN O
of ADP O
750 NUM O
. PUNCT O

MT NOUN O
, PUNCT O
microtubule NOUN O
; PUNCT O
PIV PROPN B-AC
, PUNCT O
particle NOUN B-LF
image NOUN I-LF
velocimetry NOUN I-LF
. PUNCT O

The DET O
following ADJ O
variables NOUN O
were AUX O
available ADJ O
for ADP O
analysis NOUN O
: PUNCT O
age NOUN O
, PUNCT O
sex NOUN O
, PUNCT O
ethnicity NOUN O
( PUNCT O
white ADJ O
, PUNCT O
black ADJ O
, PUNCT O
South ADJ O
Asian ADJ O
, PUNCT O
or CCONJ O
other ADJ O
) PUNCT O
, PUNCT O
smoking NOUN O
status NOUN O
( PUNCT O
current ADJ O
smoker NOUN O
, PUNCT O
previous ADJ O
smoker NOUN O
, PUNCT O
never ADV O
smoked VERB O
) PUNCT O
, PUNCT O
co NOUN O
- PUNCT O
morbidities NOUN O
( PUNCT O
diabetes NOUN B-LF
mellitus NOUN I-LF
[ PUNCT O
DM PROPN B-AC
] PUNCT O
, PUNCT O
ischaemic ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
[ PUNCT O
IHD PROPN B-AC
] PUNCT O
, PUNCT O
cerebrovascular ADJ O
disease NOUN O
, PUNCT O
peripheral ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
[ PUNCT O
PAD PROPN B-AC
] PUNCT O
, PUNCT O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
[ PUNCT O
COPD PROPN B-AC
] PUNCT O
, PUNCT O
and CCONJ O
malignancy NOUN O
) PUNCT O
, PUNCT O
cause NOUN O
of ADP O
CKD PROPN B-AC
( PUNCT O
vascular ADJ O
, PUNCT O
diabetes NOUN O
, PUNCT O
glomerular ADJ O
, PUNCT O
tubulointerstitial ADJ O
, PUNCT O
cystic ADJ O
or CCONJ O
congenital ADJ O
, PUNCT O
or CCONJ O
other ADJ O
or CCONJ O
unknown ADJ O
) PUNCT O
, PUNCT O
mean ADJ B-LF
arterial ADJ I-LF
pressure NOUN I-LF
( PUNCT O
MAP PROPN B-AC
) PUNCT O
, PUNCT O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT O
eGFR PROPN B-AC
, PUNCT O
calculated VERB O
using VERB O
the DET O
4 NUM O
- PUNCT O
variable NOUN O
Modification PROPN O
of ADP O
Diet PROPN O
in ADP O
Renal PROPN O
Disease PROPN O
formula NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
urine NOUN O
albumin NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
creatinine NOUN I-LF
ratio NOUN I-LF
( PUNCT O
ACR PROPN B-AC
) PUNCT O
. PUNCT O

Following VERB O
this DET O
further ADJ O
simplification NOUN O
we PRON O
obtain VERB O
a DET O
new ADJ O
death NOUN O
model NOUN O
, PUNCT O
with ADP O
only ADV O
three NUM O
coefficients NOUN O
to PART O
estimate:(13)Finally VERB O
, PUNCT O
because SCONJ O
the DET O
values NOUN O
of ADP O
, PUNCT O
, PUNCT O
and CCONJ O
Ra NOUN O
come VERB O
with ADP O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT O
CIs NOUN B-AC
) PUNCT O
, PUNCT O
we PRON O
need VERB O
to PART O
account VERB O
for ADP O
this DET O
uncertainty NOUN O
when SCONJ O
computing VERB O
CFRs NOUN B-AC
. PUNCT O
For ADP O
each DET O
age NOUN O
group NOUN O
a DET O
, PUNCT O
we PRON O
proceed VERB O
as ADP O
follows VERB O
. PUNCT O
( PUNCT O
1 X O
) PUNCT O
We PRON O
generate VERB O
K NOUN O
= SYM O
1,000 NUM O
sample NOUN O
datasets NOUN O
, PUNCT O
where SCONJ O
and CCONJ O
are AUX O
sampled VERB O
from ADP O
a DET O
normal ADJ O
distribution NOUN O
with ADP O
the DET O
same ADJ O
mean NOUN O
and CCONJ O
95 NUM O
% NOUN O
CI NOUN B-AC
as ADP O
in ADP O
Tables NOUN O
S2 NUM O
and CCONJ O
S3 NOUN O
of ADP O
Text NOUN O
S1 NOUN O
, PUNCT O
whereas SCONJ O
values NOUN O
are AUX O
obtained VERB O
by ADP O
running VERB O
our PRON O
model NOUN O
parameters NOUN O
sampled VERB O
from ADP O
the DET O
joint ADJ O
posterior ADJ O
distribution NOUN O
of ADP O
our PRON O
MCMC PROPN B-AC
analysis NOUN O
. PUNCT O
( PUNCT O
2 X O
) PUNCT O
We PRON O
fit VERB O
the DET O
death NOUN O
model NOUN O
for ADP O
each DET O
replicate NOUN O
k NOUN O
by ADP O
maximum NOUN O
likelihood NOUN O
using VERB O
the DET O
function NOUN O
glm.nb NOUN O
of ADP O
R NOUN O
2.15.1 NUM O
[ PUNCT O
35 NUM O
] PUNCT O
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
screened VERB O
for ADP O
new ADJ O
sporulation NOUN O
genes NOUN O
using VERB O
a DET O
transposon NOUN B-LF
- NOUN I-LF
sequencing VERB I-LF
( PUNCT O
Tn PROPN B-AC
- NOUN B-AC
seq NOUN B-AC
) PUNCT O
approach NOUN O
[ PUNCT O
28 NUM O
] PUNCT O
. PUNCT O

The DET O
white ADJ O
asterisks NOUN O
represent VERB O
the DET O
CF PROPN B-AC
located VERB O
at ADP O
1 NUM O
and CCONJ O
21 NUM O
kHz NOUN O
, PUNCT O
respectively ADV O
. PUNCT O
( PUNCT O
B NOUN O
) PUNCT O
Figure NOUN O
shows VERB O
the DET O
color NOUN O
- PUNCT O
coded VERB O
locations NOUN O
of ADP O
the DET O
recording VERB O
sites NOUN O
within ADP O
the DET O
schematic ADJ O
representation NOUN O
of ADP O
the DET O
parcellation NOUN O
of ADP O
the DET O
auditory ADJ O
cortex NOUN O
[ PUNCT O
( PUNCT O
AAF PROPN O
( PUNCT O
anterior ADJ O
auditory ADJ O
field NOUN O
) PUNCT O
, PUNCT O
AI PROPN B-AC
( PUNCT O
primary ADJ B-LF
auditory ADJ I-LF
cortex NOUN I-LF
) PUNCT O
, PUNCT O
D PROPN O
( PUNCT O
dorsal ADJ O
field NOUN O
) PUNCT O
, PUNCT O
DP PROPN O
( PUNCT O
dorsoposterior ADJ O
field NOUN O
) PUNCT O
, PUNCT O
V NOUN O
( PUNCT O
ventral ADJ O
field NOUN O
) PUNCT O
, PUNCT O
VP PROPN O
( PUNCT O
ventroposterior ADJ O
field NOUN O
) PUNCT O
] PUNCT O
. PUNCT O

Essential ADJ O
data NOUN O
are AUX O
available ADJ O
on ADP O
https://git.io/JTg1l X O
. PUNCT O
a.u NOUN O
. PUNCT O
, PUNCT O
arbitrary ADJ O
units NOUN O
; PUNCT O
GD PROPN B-AC
, PUNCT O
geodesic ADJ B-LF
distance NOUN I-LF
; PUNCT O
MPC NOUN B-AC
, PUNCT O
microstructure NOUN B-LF
profile NOUN I-LF
covariance NOUN I-LF
; PUNCT O
TS PROPN O
, PUNCT O
tractography NOUN O
strength NOUN O
. PUNCT O

Plasma NOUN O
levels NOUN O
of ADP O
NAD+ NOUN O
and CCONJ O
its PRON O
metabolites NOUN O
[ X O
NADP+ NOUN O
, PUNCT O
cyclic ADJ B-LF
ADP NOUN I-LF
ribose NOUN I-LF
( PUNCT O
cADPR PROPN B-AC
) PUNCT O
, PUNCT O
nicotinamide NOUN B-LF
( PUNCT O
NAM PROPN B-AC
) PUNCT O
, PUNCT O
N NOUN B-LF
- NOUN I-LF
methylnicotinamide NOUN I-LF
( PUNCT O
MeNAM NOUN B-AC
) PUNCT O
] PUNCT O
were AUX O
measured VERB O
by ADP O
liquid NOUN O
chromatography NOUN O
coupled VERB O
to ADP O
tandem ADJ O
mass NOUN O
spectrometry NOUN O
( PUNCT O
LC NOUN O
/ SYM O
MS PROPN O
/ SYM O
MS PROPN O
) PUNCT O
, PUNCT O
as SCONJ O
previously ADV O
described VERB O
[ X O
25 NUM O
] PUNCT O
. PUNCT O

As SCONJ O
ART PROPN B-AC
coverage NOUN O
increases NOUN O
from ADP O
10 NUM O
% PUNCT O
to ADP O
97 NUM O
% PUNCT O
of ADP O
eligible ADJ O
employees NOUN O
, PUNCT O
increases NOUN O
in ADP O
survival NOUN O
and CCONJ O
retention NOUN O
of ADP O
HIV PROPN O
- PUNCT O
positive ADJ O
employees NOUN O
and CCONJ O
associated VERB O
reductions NOUN O
in ADP O
absenteeism NOUN O
and CCONJ O
benefit NOUN O
payments NOUN O
lead VERB O
to ADP O
cost NOUN O
savings NOUN O
compared VERB O
to ADP O
a DET O
scenario NOUN O
of ADP O
no DET O
treatment NOUN O
provision NOUN O
, PUNCT O
with ADP O
the DET O
annual ADJ O
cost NOUN O
of ADP O
HIV PROPN O
to ADP O
the DET O
company NOUN O
decreasing VERB O
by ADP O
5 NUM O
% PUNCT O
( PUNCT O
90 NUM O
% PUNCT O
credibility NOUN B-LF
interval NOUN I-LF
[ X O
CrI NOUN B-AC
] X O
2%–8 NUM O
% PUNCT O
) PUNCT O
and CCONJ O
the DET O
mean ADJ O
cost NOUN O
per ADP O
HIV PROPN O
- PUNCT O
positive ADJ O
employee NOUN O
decreasing VERB O
by ADP O
14 NUM O
% PUNCT O
( PUNCT O
90 NUM O
% PUNCT O
CrI NOUN B-AC
7%–19 NUM O
% PUNCT O
) PUNCT O
by ADP O
2022 NUM O
. PUNCT O

We PRON O
used VERB O
data NOUN O
from ADP O
14,633 NUM O
singleton ADJ O
live ADJ O
birth NOUN O
pregnancies NOUN O
from ADP O
women NOUN O
participating VERB O
in ADP O
13 NUM O
studies NOUN O
conducted VERB O
from ADP O
1996 NUM O
to ADP O
2015 NUM O
in ADP O
8 NUM O
African ADJ O
countries NOUN O
and CCONJ O
the DET O
Western PROPN O
Pacific PROPN O
( PUNCT O
PNG PROPN B-AC
) PUNCT O
as ADP O
part NOUN O
of ADP O
the DET O
Maternal PROPN B-LF
Malaria PROPN I-LF
and CCONJ I-LF
Malnutrition PROPN I-LF
( PUNCT O
M3 PROPN B-AC
) PUNCT O
initiative NOUN O
[ X O
9,11,13–24 NUM O
] PUNCT O
. PUNCT O

Participants NOUN O
were AUX O
randomly ADV O
allocated VERB O
in ADP O
a DET O
1∶1 NUM O
ratio NOUN O
to ADP O
induction NOUN B-LF
of ADP I-LF
labor NOUN I-LF
( PUNCT O
IoL PROPN B-AC
) PUNCT O
or CCONJ O
expectant ADJ B-LF
management NOUN I-LF
( PUNCT O
EM PROPN B-AC
) PUNCT O
using VERB O
block NOUN O
randomization NOUN O
. PUNCT O

BMI PROPN B-AC
, PUNCT O
Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
BW PROPN B-AC
, PUNCT O
Birthweight NOUN B-LF
. PUNCT O

Expression NOUN O
of ADP O
steroid NOUN B-LF
5α NOUN I-LF
- NOUN I-LF
reductase NOUN I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT O
SRD5A2 NOUN B-AC
) PUNCT O
was AUX O
only ADV O
consistently ADV O
detectable ADJ O
in ADP O
the DET O
genital ADJ O
tubercle NOUN O
. PUNCT O

Our PRON O
primary ADJ O
MR NOUN B-AC
analysis NOUN O
method NOUN O
was AUX O
inverse ADJ B-LF
variance NOUN I-LF
weighted VERB I-LF
( PUNCT O
IVW PROPN B-AC
) PUNCT O
regression NOUN O
where SCONJ O
at ADV O
least ADV O
two NUM O
exposure NOUN O
SNPs NOUN B-AC
were AUX O
available ADJ O
for ADP O
analysis NOUN O
. PUNCT O

CKIP-1 PROPN O
, PUNCT O
casein NOUN O
kinase NOUN O
interacting VERB O
protein NOUN O
1 NUM O
; PUNCT O
H2B PROPN B-AC
, PUNCT O
histone NOUN B-LF
2B NUM I-LF
; PUNCT O
HH PROPN B-AC
, PUNCT O
Hamburger PROPN B-LF
- PUNCT I-LF
Hamilton PROPN I-LF
stage NOUN I-LF
; PUNCT O
pSmad1/5/8 NUM B-AC
, PUNCT O
phospho NOUN O
- PUNCT O
Smads NOUN O
1/5/8 NUM O
; PUNCT O
RFP PROPN B-AC
, PUNCT O
red ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT O

AMPA PROPN B-AC
, PUNCT O
α NOUN B-LF
- PUNCT I-LF
amino-3 NOUN I-LF
- PUNCT I-LF
hydroxy-5 NOUN I-LF
- PUNCT I-LF
methyl-4 NOUN I-LF
- PUNCT I-LF
isoxazolepropionic NOUN I-LF
acid NOUN I-LF
; PUNCT O
BF PROPN O
, PUNCT O
bright ADJ O
field NOUN O
; PUNCT O
CCK8 PROPN B-AC
, PUNCT O
Cell PROPN B-LF
Counting PROPN I-LF
Kit-8 PROPN I-LF
; PUNCT O
CGC PROPN B-AC
, PUNCT O
cerebellar NOUN B-LF
granule NOUN I-LF
cell NOUN I-LF
; PUNCT O
cKO PROPN B-AC
, PUNCT O
Mettl3 NOUN B-LF
conditional ADJ I-LF
knockout NOUN I-LF
; PUNCT O
CREB PROPN B-AC
, PUNCT O
cAMP NOUN B-LF
responsive ADJ I-LF
element NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT O
Ctrl PROPN B-AC
, PUNCT O
control NOUN B-LF
; PUNCT O
DIV PROPN O
, PUNCT O
days NOUN O
in ADP O
vitro ADJ O
; PUNCT O
Grin1001 PROPN O
, PUNCT O
C1 PROPN O
region NOUN O
excluded VERB O
variant NOUN O
of ADP O
Grin1 PROPN O
; PUNCT O
Grin1011 PROPN O
, PUNCT O
C1 PROPN O
region NOUN O
included VERB O
variant NOUN O
of ADP O
Grin1 PROPN O
; PUNCT O
IGV PROPN B-AC
, PUNCT O
integrative ADJ B-LF
genomics NOUN I-LF
viewer NOUN I-LF
; PUNCT O
METTL3 PROPN B-AC
, PUNCT O
methyltransferase NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
3 NUM I-LF
; PUNCT O
m6A PROPN B-AC
, PUNCT O
N6 NOUN B-LF
- PUNCT I-LF
methyladenosine NOUN I-LF
; PUNCT O
NMDA PROPN B-AC
, PUNCT O
N NOUN B-LF
- PUNCT I-LF
methyl NOUN I-LF
- PUNCT I-LF
D NOUN I-LF
- PUNCT I-LF
aspartic NOUN I-LF
acid NOUN I-LF
; PUNCT O
PKMT PROPN B-AC
, PUNCT O
Lysine NOUN B-LF
methyltransferase NOUN I-LF
; PUNCT O
PPAR PROPN B-AC
, PUNCT O
peroxisome NOUN B-LF
proliferator NOUN I-LF
- PUNCT I-LF
activated VERB I-LF
receptor NOUN I-LF
; PUNCT O
PSI PROPN B-AC
, PUNCT O
percent NOUN B-LF
spliced VERB I-LF
in ADP I-LF
index NOUN I-LF
; PUNCT O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT O
SEM NOUN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
. PUNCT O

Thus ADV O
, PUNCT O
we PRON O
determined VERB O
glycemic ADJ O
control NOUN O
of ADP O
p8 NOUN O
in ADP O
mice NOUN O
fed VERB O
with ADP O
standard ADJ O
( PUNCT O
SD PROPN B-AC
) PUNCT O
and CCONJ O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
( PUNCT O
HFD PROPN B-AC
) PUNCT O
. PUNCT O

PRCP NOUN B-AC
activity NOUN O
was AUX O
determined VERB O
by ADP O
measuring VERB O
the DET O
hydrolysis NOUN O
of ADP O
N NOUN B-LF
- NOUN I-LF
benzyloxycarbonyl NOUN I-LF
- NOUN I-LF
Pro PROPN I-LF
- NOUN I-LF
Phe PROPN I-LF
( PUNCT O
Z NOUN B-AC
- NOUN B-AC
Pro PROPN B-AC
- NOUN B-AC
Phe PROPN B-AC
; PUNCT O
Bachem PROPN O
, PUNCT O
Bubendorf PROPN O
, PUNCT O
Switzerland PROPN O
) PUNCT O
. PUNCT O

The DET O
identification NOUN O
of ADP O
all DET O
comorbidities NOUN O
, PUNCT O
except SCONJ O
traumatic ADJ O
brain NOUN O
injury NOUN O
, PUNCT O
relied VERB O
on ADP O
algorithms NOUN O
developed VERB O
by ADP O
SNDS PROPN B-AC
experts NOUN O
in ADP O
collaboration NOUN O
with ADP O
the DET O
institution NOUN O
in ADP O
charge NOUN O
of ADP O
the DET O
SNDS PROPN B-AC
, PUNCT O
the DET O
Caisse PROPN B-LF
Nationale PROPN I-LF
d’Assurance PROPN I-LF
Maladie PROPN I-LF
des PROPN I-LF
Travailleurs PROPN I-LF
Salariés PROPN I-LF
( PUNCT O
CNAMTS PROPN B-AC
) PUNCT O
[ PUNCT O
36 NUM O
] PUNCT O
. PUNCT O

The DET O
trials NOUN O
included VERB O
are AUX O
as SCONJ O
follows VERB O
: PUNCT O
9 X O
= PUNCT O
Australasian PROPN B-LF
Collaborative PROPN I-LF
Trial PROPN I-LF
of ADP I-LF
Magnesium PROPN I-LF
Sulphate PROPN I-LF
( PUNCT O
ACTOMgSO4 PROPN B-AC
) PUNCT O
, PUNCT O
10 X O
= PUNCT O
PREterm NOUN B-LF
brain NOUN I-LF
protection NOUN I-LF
by ADP I-LF
MAGnesium PROPN I-LF
sulphate NOUN I-LF
( PUNCT O
PREMAG PROPN B-AC
) PUNCT O
, PUNCT O
11 X O
= PUNCT O
Magnesium PROPN B-LF
and CCONJ I-LF
Neurologic PROPN I-LF
Endpoints PROPN I-LF
Trial PROPN I-LF
( PUNCT O
MAGNET PROPN B-AC
) PUNCT O
, PUNCT O
12 X O
= PUNCT O
MAGnesium PROPN B-LF
sulphate NOUN I-LF
for ADP I-LF
Prevention PROPN I-LF
of ADP I-LF
Eclampsia PROPN I-LF
( PUNCT O
MAGPIE PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
13 X O
= PUNCT O
Beneficial PROPN B-LF
Effects PROPN I-LF
of ADP I-LF
Antenatal PROPN I-LF
Magnesium PROPN I-LF
Sulfate PROPN I-LF
( PUNCT O
BEAM PROPN B-AC
) PUNCT O
. PUNCT O

( PUNCT O
Cr NOUN O
= PUNCT O
creatine NOUN O
; PUNCT O
PCr NOUN O
= PUNCT O
phosphocreatine NOUN O
; PUNCT O
GSH NOUN B-AC
= PUNCT O
glutathione NOUN B-LF
; PUNCT O
GABA NOUN B-AC
= PUNCT O
γ NOUN B-LF
- NOUN I-LF
amino NOUN I-LF
butyric NOUN I-LF
acid NOUN I-LF
; PUNCT O
NAA PROPN O
= PUNCT O
N NOUN O
- NOUN O
acetylaspartic NOUN O
acid NOUN O
) PUNCT O
. PUNCT O

CP NOUN B-AC
: PUNCT O
Chronic ADJ B-LF
Pain NOUN I-LF
phenotype NOUN I-LF

Abbreviations NOUN O
: PUNCT O
ANC PROPN B-AC
, PUNCT O
antenatal ADJ B-LF
care NOUN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
LOS PROPN B-AC
, PUNCT O
length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
; PUNCT O
OR NOUN B-AC
, PUNCT O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT O
ref NOUN O
, PUNCT O
reference NOUN O
; PUNCT O
SBA PROPN B-AC
, PUNCT O
skilled ADJ B-LF
birth NOUN I-LF
attendant NOUN I-LF
. PUNCT O

Within ADP O
ENSANUT PROPN O
, PUNCT O
we PRON O
used VERB O
the DET O
semiquantitative ADJ B-LF
food NOUN I-LF
frequency NOUN I-LF
questionnaire NOUN I-LF
( PUNCT O
SFFQ PROPN B-AC
) PUNCT O
to PART O
estimate VERB O
baseline ADJ O
intake NOUN O
of ADP O
beverages NOUN O
and CCONJ O
snacks NOUN O
. PUNCT O

India PROPN O
's PART O
Total PROPN B-LF
Sanitation PROPN I-LF
Campaign PROPN I-LF
( PUNCT O
TSC PROPN B-AC
) PUNCT O
is AUX O
one NUM O
such ADJ O
program NOUN O
that PRON O
seeks VERB O
to PART O
end VERB O
the DET O
practice NOUN O
of ADP O
open ADJ O
defecation NOUN O
by ADP O
changing VERB O
social ADJ O
norms NOUN O
and CCONJ O
behaviors NOUN O
, PUNCT O
and CCONJ O
providing VERB O
technical ADJ O
support NOUN O
and CCONJ O
financial ADJ O
subsidies NOUN O
. PUNCT O

OS PROPN B-AC
: PUNCT O
outer ADJ O
segment NOUN O
; PUNCT O
ONL PROPN B-AC
: PUNCT O
outer ADJ B-LF
nuclear ADJ I-LF
layer NOUN I-LF
; PUNCT O
INL PROPN B-AC
: PUNCT O
inner ADJ B-LF
nuclear ADJ I-LF
layer NOUN I-LF
; PUNCT O
GCL PROPN B-AC
: PUNCT O
ganglion NOUN B-LF
cell NOUN I-LF
layer NOUN I-LF
. PUNCT O

With SCONJ O
HIV PROPN O
prevalence NOUN O
estimated VERB O
at ADP O
7.3 NUM O
% NOUN O
among ADP O
the DET O
general ADJ O
population NOUN O
[ PUNCT O
7 NUM O
] PUNCT O
, PUNCT O
Uganda PROPN O
is AUX O
one NUM O
of ADP O
14 NUM O
priority NOUN O
countries NOUN O
identified VERB O
for ADP O
high ADJ O
- PUNCT O
level NOUN O
SMC PROPN B-AC
scale NOUN O
- PUNCT O
up NOUN O
by ADP O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
and CCONJ O
the DET O
Joint PROPN B-LF
United PROPN I-LF
Nations PROPN I-LF
Programme PROPN I-LF
on ADP I-LF
HIV PROPN I-LF
/ SYM I-LF
AIDS PROPN I-LF
( PUNCT O
UNAIDS PROPN B-AC
) PUNCT O
[ PUNCT O
8 NUM O
] PUNCT O
. PUNCT O

To PART O
calculate VERB O
QALYs NOUN B-AC
, PUNCT O
utilities NOUN O
are AUX O
necessary ADJ O
and CCONJ O
these PRON O
can AUX O
be AUX O
derived VERB O
from ADP O
preference NOUN B-LF
- PUNCT I-LF
based VERB I-LF
measures NOUN I-LF
( PUNCT O
PBMs PROPN B-AC
) PUNCT O
, PUNCT O
such ADJ O
as ADP O
the DET O
EuroQol PROPN B-LF
five NUM I-LF
- PUNCT I-LF
dimensional ADJ I-LF
questionnaire NOUN I-LF
( PUNCT O
EQ-5D PROPN B-AC
) PUNCT O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

The DET O
WHO PROPN B-AC
Study PROPN B-LF
on ADP I-LF
Global PROPN I-LF
Ageing PROPN I-LF
and CCONJ I-LF
Adult PROPN I-LF
Health PROPN I-LF
( PUNCT O
SAGE PROPN B-AC
) PUNCT O
wave NOUN O
2 NUM O
for ADP O
Ghana PROPN O
was AUX O
conducted VERB O
in ADP O
2014–2015 NUM O
, PUNCT O
as ADP O
part NOUN O
of ADP O
the DET O
multi ADJ O
- ADJ O
country ADJ O
study NOUN O
on ADP O
aging NOUN O
. PUNCT O

FFPE PROPN B-AC
, PUNCT O
formalin NOUN B-LF
- PUNCT I-LF
fixed VERB I-LF
paraffin NOUN I-LF
- PUNCT I-LF
embedded VERB I-LF
; PUNCT O
HPV PROPN B-AC
, PUNCT O
human ADJ B-LF
papillomavirus NOUN I-LF
. PUNCT O

The DET O
results NOUN O
of ADP O
the DET O
examination NOUN O
are AUX O
sent VERB O
to ADP O
US PROPN O
state NOUN O
and CCONJ O
local ADJ O
health NOUN O
departments NOUN O
via ADP O
CDC PROPN B-AC
’s PART O
Electronic PROPN B-LF
Disease PROPN I-LF
Notification PROPN I-LF
system NOUN I-LF
( PUNCT O
EDN PROPN B-AC
) PUNCT O
[ PUNCT O
4 NUM O
] PUNCT O
. PUNCT O

Depressive ADJ O
symptoms NOUN O
were AUX O
measured VERB O
by ADP O
10 NUM B-LF
- PUNCT I-LF
item NOUN I-LF
Center PROPN I-LF
for ADP I-LF
Epidemiologic PROPN I-LF
Studies PROPN I-LF
( PUNCT O
CES PROPN B-AC
- PUNCT B-AC
D PROPN B-AC
10 NUM B-AC
) PUNCT O
. PUNCT O

Similarly ADV O
, PUNCT O
degradation NOUN O
of ADP O
REV NOUN O
- PUNCT O
ERBα NOUN O
by ADP O
Homologous PROPN B-LF
to ADP I-LF
the DET I-LF
E6 PROPN I-LF
- PUNCT I-LF
AP PROPN I-LF
Carboxyl PROPN I-LF
Terminus PROPN I-LF
( PUNCT O
HECT)-(ARF PROPN B-AC
- PUNCT O
BP1 PROPN O
) PUNCT O
and CCONJ O
Really ADV B-LF
Interesting ADJ I-LF
New PROPN I-LF
Gene PROPN I-LF
( PUNCT O
RING)-class PROPN B-AC
E3 NOUN O
ligases NOUN O
( PUNCT O
PAM PROPN O
) PUNCT O
is AUX O
induced VERB O
by ADP O
phosphorylation NOUN O
by ADP O
glycogen NOUN B-LF
synthase NOUN I-LF
kinase NOUN I-LF
3β NOUN I-LF
( PUNCT O
GSK3β PROPN B-AC
) PUNCT O
[ X O
5,6 NUM O
] PUNCT O
. PUNCT O

Ceramides NOUN O
in ADP O
the DET O
epidermis NOUN O
are AUX O
synthesized VERB O
by ADP O
several ADJ O
enzymes NOUN O
such ADJ O
as ADP O
serine NOUN B-LF
palmitoyltransferase NOUN I-LF
( PUNCT O
SPT PROPN B-AC
) PUNCT O
, PUNCT O
ceramide NOUN B-LF
synthase NOUN I-LF
( PUNCT O
CerS PROPN B-AC
) PUNCT O
, PUNCT O
glucosylceramide NOUN B-LF
synthase NOUN I-LF
( PUNCT O
GCS PROPN B-AC
) PUNCT O
, PUNCT O
β NOUN O
- NOUN O
glucocerebrosidese NOUN O
( PUNCT O
GBA PROPN B-AC
) PUNCT O
, PUNCT O
sphingomyelin NOUN B-LF
synthase NOUN I-LF
( PUNCT O
SMS PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
acid NOUN B-LF
sphingomyelinase NOUN I-LF
( PUNCT O
ASM PROPN B-AC
) PUNCT O
. PUNCT O
SPT PROPN B-AC
and CCONJ O
CerS PROPN B-AC
are AUX O
involved VERB O
in ADP O
the DET O
de X O
novo X O
synthesis NOUN O
of ADP O
ceramides NOUN O
. PUNCT O

In ADP O
addition NOUN O
, PUNCT O
its PRON O
activity NOUN O
can AUX O
also ADV O
be AUX O
negatively ADV O
regulated VERB O
by ADP O
type NOUN O
I NUM O
HDACs PROPN B-AC
, PUNCT O
protein NOUN B-LF
inhibitor NOUN I-LF
of ADP I-LF
activated ADJ I-LF
STAT3 PROPN I-LF
( PUNCT O
PIAS3 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
suppressor NOUN O
of ADP O
cytokine NOUN O
signaling NOUN O
3 NUM O
( PUNCT O
SOCS3 PROPN B-AC
) PUNCT O
[ PUNCT O
38–42 NUM O
] PUNCT O
. PUNCT O

For ADP O
statistical ADJ O
analyses NOUN O
, PUNCT O
data NOUN O
were AUX O
modelled VERB O
using VERB O
a DET O
linear ADJ B-LF
model NOUN I-LF
( PUNCT O
LM PROPN B-AC
) PUNCT O
, PUNCT O
a DET O
linear ADJ B-LF
mixed ADJ I-LF
model NOUN I-LF
( PUNCT O
LMM PROPN B-AC
) PUNCT O
, PUNCT O
or CCONJ O
a DET O
general ADJ B-LF
linear ADJ I-LF
mixed ADJ I-LF
model NOUN I-LF
( PUNCT O
GLMM PROPN B-AC
) PUNCT O
with ADP O
diet NOUN O
as ADP O
fixed ADJ O
and CCONJ O
independent ADJ O
experiment NOUN O
as ADP O
random ADJ O
effect NOUN O
followed VERB O
by ADP O
a DET O
Wald PROPN O
chi NOUN O
- PUNCT O
squared ADJ O
test NOUN O
. PUNCT O

Instruments NOUN O
used VERB O
included VERB O
the DET O
Bayley PROPN B-LF
Scale PROPN I-LF
of ADP I-LF
Infant PROPN I-LF
Development- PROPN I-LF
second ADJ I-LF
edition NOUN I-LF
( PUNCT O
BSID PROPN B-AC
- PUNCT B-AC
II PROPN B-AC
) PUNCT O
[ PUNCT O
31 NUM O
] PUNCT O
, PUNCT O
Mullen PROPN B-LF
Scales PROPN I-LF
for ADP I-LF
Early PROPN I-LF
Learning PROPN I-LF
( PUNCT O
MSEL PROPN B-AC
) PUNCT O
[ PUNCT O
32 NUM O
] PUNCT O
, PUNCT O
or CCONJ O
a DET O
cognitive ADJ O
test NOUN O
such ADJ O
as ADP O
the DET O
Stanford PROPN B-LF
- PUNCT I-LF
Binet PROPN I-LF
Fourth PROPN I-LF
Edition PROPN I-LF
( PUNCT O
SB-4 PROPN B-AC
) PUNCT O
[ PUNCT O
33 NUM O
] PUNCT O
, PUNCT O
Wechsler PROPN B-LF
Preschool PROPN I-LF
and CCONJ I-LF
Primary PROPN I-LF
Scale PROPN I-LF
for ADP I-LF
Intelligence PROPN I-LF
– PUNCT I-LF
Third PROPN I-LF
Edition PROPN I-LF
( PUNCT O
WPPSI PROPN B-AC
- PUNCT B-AC
III PROPN B-AC
) PUNCT O
[ PUNCT O
34 NUM O
] PUNCT O
, PUNCT O
Wechsler PROPN B-LF
Intelligence PROPN I-LF
Scale PROPN I-LF
for ADP I-LF
Children PROPN I-LF
– PUNCT I-LF
Revised VERB I-LF
( PUNCT O
WISC PROPN B-AC
- PUNCT B-AC
R PROPN B-AC
) PUNCT O
[ PUNCT O
35 NUM O
] PUNCT O
, PUNCT O
or CCONJ O
Kaufman PROPN B-LF
Brief PROPN I-LF
Intelligence PROPN I-LF
Test PROPN I-LF
( PUNCT O
K PROPN B-AC
- PUNCT B-AC
BIT PROPN B-AC
) PUNCT O
[ PUNCT O
36 NUM O
] PUNCT O
. PUNCT O

The DET O
solubility NOUN B-LF
product NOUN I-LF
constant NOUN O
, PUNCT O
Ksp PROPN B-AC
, PUNCT O
is AUX O
the DET O
equilibrium NOUN O
constant NOUN O
used VERB O
to PART O
describe VERB O
the DET O
dissolution NOUN O
of ADP O
a DET O
solid ADJ O
in ADP O
a DET O
solution NOUN O
. PUNCT O

CES PROPN B-AC
, PUNCT O
chromatin NOUN B-LF
entry NOUN I-LF
site NOUN I-LF
; PUNCT O
MSL PROPN B-AC
, PUNCT O
male NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
lethal NOUN I-LF
. PUNCT O

AD PROPN B-AC
, PUNCT O
adult NOUN B-LF
day NOUN I-LF
; PUNCT O
CHC PROPN B-AC
, PUNCT O
cuticular ADJ B-LF
hydrocarbon NOUN I-LF
; PUNCT O
RNAi NOUN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT O

Women NOUN O
were AUX O
classified VERB O
into ADP O
three NUM O
groups NOUN O
according VERB O
to ADP O
FPG PROPN B-AC
level NOUN O
and CCONJ O
self NOUN O
- PUNCT O
reported VERB O
history NOUN O
of ADP O
DM PROPN B-AC
( PUNCT O
normal ADJ O
FPG PROPN B-AC
group NOUN O
: PUNCT O
FPG PROPN B-AC
< ADP O
5.6 NUM O
mmol NOUN O
/ SYM O
L NOUN O
and CCONJ O
no DET O
self NOUN O
- PUNCT O
reported VERB O
history NOUN O
of ADP O
DM PROPN B-AC
; PUNCT O
impaired ADJ B-LF
fasting ADJ I-LF
glucose NOUN I-LF
[ PUNCT O
IFG PROPN B-AC
] PUNCT O
: PUNCT O
FPG PROPN B-AC
5.6–6.9 NUM O
mmol NOUN O
/ SYM O
L NOUN O
and CCONJ O
no DET O
self NOUN O
- PUNCT O
reported VERB O
history NOUN O
of ADP O
DM PROPN B-AC
; PUNCT O
and CCONJ O
DM PROPN B-AC
: PUNCT O
FPG PROPN B-AC
≥ ADP O
7.0 NUM O
mmol NOUN O
/ SYM O
L NOUN O
or CCONJ O
self NOUN O
- PUNCT O
reported VERB O
history NOUN O
of ADP O
DM PROPN B-AC
) PUNCT O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

Our PRON O
results NOUN O
demonstrate VERB O
that SCONJ O
the DET O
long ADJ O
- PUNCT O
term NOUN O
expression NOUN O
of ADP O
disease NOUN O
- PUNCT O
causing VERB O
misfolded ADJ O
proteins NOUN O
can AUX O
lead VERB O
to ADP O
an DET O
abnormal ADJ O
, PUNCT O
chronic ADJ O
stress NOUN O
response NOUN O
that SCONJ O
we PRON O
now ADV O
refer VERB O
to ADP O
as ADP O
the DET O
maladaptive ADJ B-LF
stress NOUN I-LF
response NOUN I-LF
( PUNCT O
MSR PROPN B-AC
) PUNCT O
. PUNCT O
This DET O
altered ADJ O
Q NOUN O
- PUNCT O
state NOUN O
[ PUNCT O
3]–[6 X O
] PUNCT O
, PUNCT O
which PRON O
emphasizes VERB O
that SCONJ O
the DET O
structure NOUN O
of ADP O
a DET O
protein NOUN O
is AUX O
tightly ADV O
integrated VERB O
with ADP O
a DET O
dynamic ADJ O
proteostatic ADJ O
system NOUN O
[ PUNCT O
1],[5],[6],[9 NUM O
] PUNCT O
, PUNCT O
negatively ADV O
impacts VERB O
the DET O
folding NOUN O
of ADP O
disease NOUN O
- PUNCT O
associated VERB O
proteins NOUN O
, PUNCT O
such ADJ O
as ADP O
F508del PROPN O
- PUNCT O
CFTR PROPN B-AC
[ PUNCT O
42 NUM O
] PUNCT O
, PUNCT O
leading VERB O
to ADP O
a DET O
self NOUN O
- PUNCT O
propagating VERB O
proteotoxic ADJ O
crisis NOUN O
( PUNCT O
Figure PROPN O
8) NUM O
. PUNCT O

OPSCC PROPN B-AC
, PUNCT O
oropharyngeal ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
; PUNCT O
HPV PROPN B-AC
, PUNCT O
human ADJ B-LF
papillomavirus NOUN I-LF
; PUNCT O
FFPE PROPN B-AC
, PUNCT O
formalin NOUN B-LF
- PUNCT I-LF
fixed VERB I-LF
, PUNCT I-LF
paraffin NOUN I-LF
- PUNCT I-LF
embedded VERB I-LF
; PUNCT O
IHC PROPN B-AC
, PUNCT O
immunohistochemical ADJ B-LF
staining NOUN I-LF
; PUNCT O
PCR NOUN B-AC
- PUNCT B-AC
MA PROPN B-AC
, PUNCT O
multiplex ADJ B-LF
PCR NOUN I-LF
- PUNCT I-LF
MassArray PROPN I-LF
. PUNCT O

AM INTJ B-AC
, PUNCT O
acute ADJ B-LF
malnutrition NOUN I-LF
. PUNCT O

Paper NOUN B-LF
- PUNCT I-LF
based VERB I-LF
Data PROPN I-LF
Capture PROPN I-LF
( PUNCT O
PDC PROPN B-AC
) PUNCT O
has AUX O
historically ADV O
been AUX O
the DET O
main ADJ O
method NOUN O
used VERB O
to PART O
record VERB O
information NOUN O
. PUNCT O

Naïve ADJ O
T PROPN O
cells NOUN O
require VERB O
activation NOUN O
by ADP O
dendritic ADJ B-LF
cells NOUN I-LF
( PUNCT O
DCs PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
AHR PROPN B-AC
ligands NOUN O
modulate VERB O
the DET O
function NOUN O
of ADP O
DCs PROPN B-AC
from ADP O
adult ADJ O
organisms NOUN O
. PUNCT O

6MWT PROPN B-AC
: PUNCT O
6 NUM B-LF
- PUNCT I-LF
minute NOUN I-LF
walk NOUN I-LF
test NOUN I-LF
( PUNCT O
m NOUN O
: PUNCT O
distance NOUN O
in ADP O
meters NOUN O
) PUNCT O
. PUNCT O

In ADP O
the DET O
past ADJ O
decades NOUN O
, PUNCT O
quantitative ADJ B-LF
EEG PROPN I-LF
( PUNCT O
qEEG PROPN B-AC
) PUNCT O
analysis NOUN O
methods NOUN O
have AUX O
been AUX O
developed VERB O
to PART O
identify VERB O
epilepsy NOUN O
- PUNCT O
related VERB O
signals NOUN O
[ X O
9–14 NUM O
] PUNCT O
. PUNCT O
qEEG PROPN B-AC
is AUX O
more ADV O
objective ADJ O
than ADP O
visual ADJ O
analysis NOUN O
and CCONJ O
may AUX O
reveal VERB O
subtle ADJ O
signal NOUN O
features NOUN O
and CCONJ O
dynamics NOUN O
that PRON O
are AUX O
difficult ADJ O
or CCONJ O
impossible ADJ O
to PART O
detect VERB O
by ADP O
visual ADJ O
inspection NOUN O
. PUNCT O

HR NOUN B-AC
, PUNCT O
hazard NOUN B-LF
ratio NOUN I-LF
. PUNCT O

In ADP O
2006 NUM O
, PUNCT O
the DET O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT O
WHO PROPN B-AC
) PUNCT O
recognised VERB O
SCA PROPN B-AC
as ADP O
a DET O
global ADJ O
public ADJ O
health NOUN O
problem NOUN O
[ PUNCT O
18 NUM O
] PUNCT O
. PUNCT O

RNA NOUN O
prepared VERB O
from ADP O
epidydimis PROPN O
was AUX O
used VERB O
as ADP O
positive ADJ O
control NOUN O
of ADP O
Hoxa1 PROPN O
and CCONJ O
Hoxb1 PROPN O
. PUNCT O
cDNA NOUN O
products NOUN O
were AUX O
resolved VERB O
on ADP O
2 NUM O
% NOUN O
( PUNCT O
w NOUN O
/ SYM O
v NOUN O
) PUNCT O
agarose NOUN O
gels NOUN O
. PUNCT O
cDNA NOUN O
, PUNCT O
complementary ADJ O
DNA NOUN O
; PUNCT O
HTF PROPN B-AC
, PUNCT O
human ADJ B-LF
tubal ADJ I-LF
fluid NOUN I-LF
; PUNCT O
PC PROPN O
, PUNCT O
positive ADJ O
control NOUN O
; PUNCT O
RT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
, PUNCT O
reverse ADJ O
transcription NOUN O
PCR NOUN O
; PUNCT O
TLR7/8 PROPN B-AC
, PUNCT O
Toll NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
7 NUM I-LF
/ SYM I-LF
Toll NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
8 NUM I-LF
. PUNCT O

BBS4 PROPN B-AC
, PUNCT O
Bardet PROPN B-LF
– PUNCT I-LF
Biedl PROPN I-LF
syndrome PROPN I-LF
4 NUM I-LF
; PUNCT O
NRF2 PROPN B-AC
, PUNCT O
nuclear ADJ B-LF
factor NOUN I-LF
- PUNCT I-LF
erythroid NOUN I-LF
2 NUM I-LF
- PUNCT I-LF
like ADJ I-LF
2 NUM I-LF
. PUNCT O

FSC PROPN O
- PUNCT O
A PROPN O
, PUNCT O
forward ADJ O
scatter NOUN O
area NOUN O
; PUNCT O
FSC PROPN O
- PUNCT O
H PROPN O
, PUNCT O
forward ADJ O
scatter NOUN O
height NOUN O
; PUNCT O
Hoxa11 PROPN B-AC
, PUNCT O
Homeobox PROPN B-LF
a11 NOUN I-LF
; PUNCT O
NK PROPN B-AC
, PUNCT O
natural ADJ B-LF
killer NOUN I-LF
; PUNCT O
Treg PROPN B-AC
, PUNCT O
T PROPN B-LF
regulatory ADJ I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT O

CBV PROPN B-AC
, PUNCT O
cerebral ADJ B-LF
blood NOUN I-LF
volume NOUN I-LF
; PUNCT O
NIRS PROPN B-AC
, PUNCT O
near ADJ B-LF
- PUNCT I-LF
infrared ADJ I-LF
spectroscopy NOUN I-LF
. PUNCT O

The DET O
C NOUN B-LF
- ADJ I-LF
terminal ADJ I-LF
fragment NOUN I-LF
of ADP I-LF
ubiquitin NOUN I-LF
( PUNCT O
Cub PROPN B-AC
) PUNCT O
was AUX O
fused VERB O
to ADP O
either CCONJ O
the DET O
N- NOUN O
or CCONJ O
C NOUN O
- ADJ O
terminal ADJ O
end NOUN O
of ADP O
Stt7 PROPN O
and CCONJ O
expressed VERB O
in ADP O
yeast NOUN O
together ADV O
with SCONJ O
the DET O
N NOUN B-LF
- ADJ I-LF
terminal ADJ I-LF
end NOUN I-LF
of ADP I-LF
ubiquitin NOUN I-LF
( PUNCT O
Nub PROPN B-AC
) PUNCT O
fused VERB O
to ADP O
the DET O
C NOUN O
- ADJ O
terminal ADJ O
end NOUN O
of ADP O
the DET O
endoplasmic ADJ O
reticulum NOUN O
( PUNCT O
ER PROPN O
) PUNCT O
protein NOUN O
Alg5 PROPN O
, PUNCT O
which PRON O
places VERB O
Nub PROPN B-AC
on ADP O
the DET O
cytoplasmic ADJ O
side NOUN O
of ADP O
the DET O
membrane NOUN O
. PUNCT O

Of ADP O
all DET O
ABMR PROPN B-AC
episodes NOUN O
( PUNCT O
n NOUN O
= SYM O
12 NUM O
) PUNCT O
, PUNCT O
2 NUM O
were AUX O
associated VERB O
with ADP O
antibodies NOUN O
to ADP O
angiotensin NOUN B-LF
II NUM I-LF
type NOUN I-LF
1 NUM I-LF
receptor NOUN I-LF
( PUNCT O
AT1R PROPN B-AC
) PUNCT O
and CCONJ O
one NUM O
with ADP O
an DET O
ABO PROPN O
- PUNCT O
incompatible ADJ O
transplant NOUN O
. PUNCT O

Reduced VERB O
long ADJ B-LF
- PUNCT I-LF
term NOUN I-LF
depression NOUN I-LF
( PUNCT O
LTD NOUN B-AC
) PUNCT O
was AUX O
recently ADV O
reported VERB O
in ADP O
TSC PROPN B-AC
mutant ADJ O
mice NOUN O
. PUNCT O

There PRON O
was AUX O
no DET O
difference NOUN O
between ADP O
the DET O
genotypes NOUN O
with ADP O
regard NOUN O
to ADP O
T PROPN O
cell NOUN O
survival NOUN O
( PUNCT O
Figure PROPN O
6A NUM O
) PUNCT O
. PUNCT O
Proliferative ADJ O
ability NOUN O
was AUX O
addressed VERB O
by ADP O
stimulating VERB O
purified ADJ O
B PROPN O
cells NOUN O
with ADP O
anti ADJ O
- ADJ O
μ ADJ O
F(ab′)2 NOUN O
or CCONJ O
lipopolysaccharide NOUN B-LF
( PUNCT O
LPS PROPN B-AC
) PUNCT O
and CCONJ O
measuring VERB O
3H NOUN O
- ADJ O
thymidine NOUN O
incorporation NOUN O
( PUNCT O
Figure PROPN O
6C NUM O
) PUNCT O
. PUNCT O
c NOUN O
- ADJ O
IAP2H570A NOUN O
/ SYM O
H570A PROPN O
B PROPN O
cells NOUN O
had VERB O
enhanced VERB O
responses NOUN O
to ADP O
both DET O
stimuli NOUN O
, PUNCT O
with ADP O
approximately ADV O
a PRON O
3 ADV O
- ADJ O
fold ADJ O
shift NOUN O
in ADP O
the DET O
dose NOUN O
response NOUN O
curve NOUN O
toward ADP O
lesser ADJ O
concentrations NOUN O
of ADP O
stimulus NOUN O
compared VERB O
to ADP O
wild ADJ O
type NOUN O
cells NOUN O
. PUNCT O

In ADP O
this DET O
study NOUN O
, PUNCT O
we PRON O
used VERB O
gene NOUN B-LF
set NOUN I-LF
enrichment NOUN I-LF
analysis NOUN I-LF
( PUNCT O
GSEA PROPN B-AC
) PUNCT O
[ X O
39 NUM O
] X O
to PART O
explore VERB O
a DET O
gene NOUN O
expression NOUN O
data NOUN O
set NOUN O
derived VERB O
from ADP O
endoscopic ADJ O
biopsies NOUN O
of ADP O
polypoid ADJ O
and CCONJ O
nonpolypoid ADJ O
colorectal ADJ O
adenomas NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
APGAR PROPN B-AC
, PUNCT O
appearance NOUN B-LF
, PUNCT I-LF
pulse NOUN I-LF
, PUNCT I-LF
grimace NOUN I-LF
, PUNCT I-LF
activity NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
respiration NOUN I-LF
; PUNCT O
CBS PROPN B-AC
, PUNCT O
Statistics PROPN B-LF
Netherlands PROPN I-LF
; PUNCT O
CI PROPN B-AC
, PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
CIN PROPN B-AC
, PUNCT O
cervical ADJ B-LF
intraepithelial ADJ I-LF
neoplasia NOUN I-LF
; PUNCT O
IVF PROPN B-AC
, PUNCT O
in ADP B-LF
vitro X I-LF
fertilization NOUN I-LF
; PUNCT O
NICU PROPN O
, PUNCT O
neonatal ADJ O
intensive PROPN O
care NOUN O
unit NOUN O
; PUNCT O
pPROM NOUN B-AC
, PUNCT O
preterm ADJ B-LF
premature ADJ I-LF
rupture NOUN I-LF
of ADP I-LF
membranes NOUN I-LF
. PUNCT O

OPD PROPN B-AC
: PUNCT O
o NOUN B-LF
- NOUN I-LF
phenylenediamine NOUN I-LF
dihydrochloride NOUN I-LF
. PUNCT O
( PUNCT O
C NOUN O
) PUNCT O
Px43 NOUN O
IgG1 NOUN O
and CCONJ O
IgG4 NOUN O
demonstrate VERB O
different ADJ O
relative ADJ O
affinities NOUN O
by ADP O
ELISA PROPN O
but CCONJ O
comparable ADJ O
affinity NOUN O
by ADP O
IIF PROPN B-AC
binding VERB O
of ADP O
human ADJ O
skin NOUN O
. PUNCT O

Among ADP O
325 NUM O
medical ADJ O
records NOUN O
identified VERB O
and CCONJ O
examined VERB O
, PUNCT O
292 NUM O
( PUNCT O
89.8 NUM O
% NOUN O
) PUNCT O
patients NOUN O
from ADP O
12 NUM O
different ADJ O
non ADJ O
- PUNCT O
Arabic ADJ O
- PUNCT O
speaking VERB O
tribes NOUN O
disclosed VERB O
in ADP O
the DET O
medical ADJ O
notes NOUN O
that SCONJ O
they PRON O
had AUX O
been AUX O
attacked VERB O
by ADP O
Government PROPN B-LF
of ADP I-LF
Sudan PROPN I-LF
( PUNCT O
GoS PROPN B-AC
) PUNCT O
and/or CCONJ O
Janjaweed PROPN O
forces NOUN O
. PUNCT O

Data NOUN O
on ADP O
the DET O
lifetime NOUN O
presence NOUN O
and CCONJ O
age NOUN O
- PUNCT O
of ADP O
- PUNCT O
onset NOUN O
of ADP O
Diagnostic PROPN B-LF
and CCONJ I-LF
Statistical PROPN I-LF
Manual PROPN I-LF
of ADP I-LF
Mental PROPN I-LF
Disorders PROPN I-LF
, PUNCT I-LF
4th PROPN I-LF
Edition PROPN I-LF
( PUNCT O
DSM PROPN B-AC
- PUNCT B-AC
IV PROPN B-AC
) PUNCT O
mental ADJ O
disorders NOUN O
and CCONJ O
nonfatal ADJ O
suicidal ADJ O
behaviors NOUN O
were AUX O
collected VERB O
via ADP O
structured ADJ O
face NOUN O
- PUNCT O
to ADP O
- PUNCT O
face NOUN O
interviews NOUN O
with ADP O
108,664 NUM O
respondents NOUN O
from ADP O
21 NUM O
countries NOUN O
participating VERB O
in ADP O
the DET O
WHO PROPN O
World PROPN O
Mental PROPN O
Health PROPN O
Surveys PROPN O
. PUNCT O

Incremental ADJ B-LF
cost NOUN I-LF
- PUNCT I-LF
effectiveness NOUN I-LF
ratios NOUN I-LF
( PUNCT O
ICERs NOUN B-AC
) PUNCT O
were AUX O
reported VERB O
separately ADV O
for ADP O
the DET O
four NUM O
LOS PROPN B-AC
models NOUN O
( PUNCT O
2 NUM O
, PUNCT O
6 NUM O
, PUNCT O
24 NUM O
, PUNCT O
36 NUM O
months NOUN O
) PUNCT O
. PUNCT O

Finally ADV O
, PUNCT O
the DET O
Na+ NOUN O
channel NOUN O
blocker NOUN O
tetrodotoxin NOUN B-LF
( PUNCT O
TTX PROPN B-AC
) PUNCT O
was AUX O
added VERB O
to PART O
the DET O
MEA PROPN B-AC
and CCONJ O
perfusion NOUN O
media NOUN O
to PART O
suppress VERB O
spontaneous ADJ O
network NOUN O
activity NOUN O
, PUNCT O
and CCONJ O
imaging NOUN O
was AUX O
continued VERB O
for ADP O
additional ADJ O
1–2 NUM O
d. NOUN O

BMI- PROPN B-AC
Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
, PUNCT O
WC- PROPN B-AC
Waist NOUN B-LF
circumference NOUN I-LF
, PUNCT O
WHR- NOUN B-AC
Waist NOUN B-LF
hip NOUN I-LF
ratio NOUN I-LF
, PUNCT O
MET PROPN O
– PUNCT O
Metabolic PROPN O
Equivalent PROPN O
, PUNCT O
SD NOUN O
– PUNCT O
standard ADJ O
deviation NOUN O

The DET O
survey NOUN O
instrument NOUN O
was AUX O
adapted VERB O
from ADP O
the DET O
Zambia PROPN O
Demographic PROPN B-LF
and CCONJ I-LF
Health PROPN I-LF
Surveys PROPN I-LF
( PUNCT O
DHS PROPN B-AC
) PUNCT O
[ X O
22 NUM O
] X O
and CCONJ O
comprised VERB O
three NUM O
parts NOUN O
. PUNCT O

On ADP O
chromosome NOUN O
6A NOUN O
a DET O
locus NOUN O
was AUX O
detected VERB O
for ADP O
DSB NOUN B-AC
and CCONJ O
HI NOUN B-AC
in ADP O
the DET O
north NOUN O
and CCONJ O
the DET O
south NOUN O
reducing VERB O
the DET O
number NOUN B-LF
of ADP I-LF
days NOUN I-LF
from ADP I-LF
sowing VERB I-LF
to ADP I-LF
booting NOUN I-LF
and CCONJ O
increasing VERB O
HI NOUN B-AC
. PUNCT O
Chromosome NOUN O
6B NUM O
reported VERB O
the DET O
highest ADJ O
number NOUN O
of ADP O
regions NOUN O
with ADP O
stable ADJ O
MTAs NOUN B-AC
( PUNCT O
3 NUM O
) PUNCT O
. PUNCT O

OPV PROPN B-AC
, PUNCT O
oral ADJ B-LF
poliovirus NOUN I-LF
vaccine NOUN I-LF
. PUNCT O

CID NOUN B-AC
, PUNCT O
complexity NOUN O
invariant ADJ O
distance NOUN O
; PUNCT O
DTW PROPN B-AC
, PUNCT O
dynamic ADJ B-LF
time NOUN I-LF
warping VERB I-LF
distance NOUN O
; PUNCT O
variance NOUN O
, PUNCT O
fraction NOUN O
of ADP O
variance NOUN O
explained VERB O
by ADP O
the DET O
clustering NOUN O
; PUNCT O
silhouette NOUN O
, PUNCT O
average ADJ O
silhouette NOUN O
width NOUN O
for ADP O
all DET O
glycemic ADJ O
signature NOUN O
; PUNCT O
CH PROPN B-AC
index NOUN O
, PUNCT O
Calinski PROPN B-LF
- PUNCT I-LF
Harabasz PROPN I-LF
index NOUN O
. PUNCT O

If SCONJ O
we PRON O
assume VERB O
that SCONJ O
the DET O
particles NOUN O
are AUX O
rigid ADJ O
spherical ADJ O
, PUNCT O
the DET O
correlation NOUN O
between ADP O
DM PROPN B-AC
specific ADJ O
resistance NOUN O
and CCONJ O
DM PROPN B-LF
layer NOUN I-LF
porosity NOUN I-LF
can AUX O
be AUX O
described VERB O
by ADP O
Carman PROPN O
- PUNCT O
Kozeny PROPN O
equation NOUN O
[ X O
26 NUM O
] PUNCT O
. PUNCT O
α=180(1−εp)ρpdp2εp3(8 NOUN B-AC
) PUNCT O
where SCONJ O
ε NOUN O
p NOUN O
is AUX O
the DET O
porosity NOUN O
of ADP O
DM PROPN B-AC
layer NOUN O
, PUNCT O
ρ NOUN O
p NOUN O
is AUX O
the DET O
density NOUN O
of ADP O
particle NOUN O
( PUNCT O
kg NOUN O
/ SYM O
m3 NOUN O
) PUNCT O
, PUNCT O
and CCONJ O
d NOUN O
p NOUN O
is AUX O
the DET O
particle NOUN O
diameter NOUN O
( PUNCT O
m NOUN O
) PUNCT O
. PUNCT O

We PRON O
conducted VERB O
an DET O
acceptability NOUN O
, PUNCT O
feasibility NOUN O
, PUNCT O
and CCONJ O
prevalence NOUN O
study NOUN O
of ADP O
home NOUN O
- PUNCT O
based VERB O
sampling NOUN O
for ADP O
STIs PROPN B-AC
/ SYM O
BV PROPN B-AC
among ADP O
young ADJ O
men NOUN O
and CCONJ O
women NOUN O
aged VERB O
15–24 NUM O
years NOUN O
old ADJ O
in ADP O
a DET O
health NOUN B-LF
and CCONJ I-LF
demographic ADJ I-LF
surveillance NOUN I-LF
site NOUN I-LF
( PUNCT O
HDSS PROPN B-AC
) PUNCT O
in ADP O
rural ADJ O
KwaZulu PROPN O
- PUNCT O
Natal PROPN O
, PUNCT O
South PROPN O
Africa PROPN O
. PUNCT O

Sn PROPN B-AC
, PUNCT O
sensitivitiy NOUN O
; PUNCT O
Sp PROPN B-AC
, PUNCT O
specificity NOUN B-LF
; PUNCT O
PPV NOUN B-AC
, PUNCT O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
; PUNCT O
NPV NOUN B-AC
, PUNCT O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
; PUNCT O
AUC NOUN B-AC
, PUNCT O
area NOUN O
under ADP O
the DET O
curve NOUN O
; PUNCT O
AFP PROPN B-AC
, PUNCT O
alpha NOUN B-LF
- PUNCT I-LF
fetoprotein NOUN I-LF
; PUNCT O
PIVKA PROPN B-AC
- PUNCT B-AC
II PROPN B-AC
, PUNCT O
protein NOUN B-LF
induced VERB I-LF
by ADP I-LF
vitamin NOUN I-LF
K NOUN I-LF
absence NOUN I-LF
; PUNCT O
OPN PROPN B-AC
, PUNCT O
osteopontin NOUN B-LF
; PUNCT O
DKK-1 PROPN B-AC
, PUNCT O
Dickkopf PROPN O
-1 NUM O

¶LAD X B-AC
— PUNCT O
left VERB B-LF
atrial ADJ I-LF
diameter NOUN I-LF

To PART O
address VERB O
this DET O
question NOUN O
, PUNCT O
we PRON O
utilize VERB O
a DET O
“ PUNCT O
Big ADJ O
Data PROPN O
” PUNCT O
set NOUN O
of ADP O
all DET O
discharge NOUN B-LF
summary NOUN I-LF
reports NOUN I-LF
( PUNCT O
DSRs PROPN B-AC
) PUNCT O
from ADP O
43 NUM O
tertiary ADJ O
general ADJ O
hospitals NOUN O
, PUNCT O
from ADP O
January PROPN O
1 NUM O
, PUNCT O
2010 NUM O
to ADP O
December PROPN O
31 NUM O
, PUNCT O
2012 NUM O
. PUNCT O

Moderate ADJ B-LF
acute ADJ I-LF
malnutrition NOUN I-LF
( PUNCT O
MAM PROPN B-AC
) PUNCT O
is AUX O
defined VERB O
as ADP O
a DET O
WHZ<−2 NUM B-AC
WHZ NOUN B-AC
but CCONJ O
≥−3 NUM O
WHZ NOUN B-AC
using VERB O
the DET O
WHO PROPN O
Child PROPN O
Growth PROPN O
Standards PROPN O
. PUNCT O

The DET O
whole ADJ B-LF
exome NOUN I-LF
sequencing NOUN I-LF
( PUNCT O
WES PROPN B-AC
) PUNCT O
approach NOUN O
was AUX O
taken VERB O
, PUNCT O
with ADP O
a DET O
view NOUN O
to ADP O
the DET O
molecular ADJ O
background NOUN O
of ADP O
the DET O
proband NOUN O
’s PART O
complex ADJ O
phenotype NOUN O
( PUNCT O
of ADP O
moderate ADJ O
peripheral ADJ O
neuropathy NOUN O
and CCONJ O
mental ADJ O
retardation NOUN O
) PUNCT O
being AUX O
understood VERB O
. PUNCT O

Our PRON O
data NOUN O
exemplify VERB O
that SCONJ O
( PUNCT O
i X O
) PUNCT O
Ginir PROPN B-AC
RNA NOUN O
function NOUN O
is AUX O
modulated VERB O
by ADP O
its PRON O
full ADJ O
- PUNCT O
length NOUN O
natural ADJ B-LF
antisense ADJ I-LF
transcript NOUN I-LF
( PUNCT O
NAT PROPN B-AC
; PUNCT O
Giniras PROPN B-AC
) PUNCT O
, PUNCT O
( PUNCT O
ii X O
) PUNCT O
Ginir PROPN B-AC
RNA NOUN O
targets VERB O
centrosomal ADJ B-LF
protein NOUN I-LF
112 NUM I-LF
( PUNCT O
Cep112 PROPN B-AC
) PUNCT O
and CCONJ O
alters VERB O
its PRON O
subcellular ADJ O
localisation NOUN O
by ADP O
binding VERB O
to ADP O
it PRON O
, PUNCT O
( PUNCT O
iii X O
) PUNCT O
breast NOUN B-LF
cancer NOUN I-LF
type NOUN I-LF
1 NUM I-LF
susceptibility NOUN I-LF
protein NOUN I-LF
( PUNCT O
Brca1 NOUN B-AC
) PUNCT O
and CCONJ O
Cep112 PROPN B-AC
proteins NOUN O
interact VERB O
with ADP O
each DET O
other ADJ O
in ADP O
the DET O
absence NOUN O
of ADP O
Ginir PROPN B-AC
noncoding ADJ O
RNA NOUN O
, PUNCT O
( PUNCT O
iv X O
) PUNCT O
interaction NOUN O
of ADP O
Cep112 PROPN B-AC
protein NOUN O
with ADP O
Brca1 NOUN B-AC
protein NOUN O
is AUX O
impaired VERB O
in ADP O
the DET O
presence NOUN O
of ADP O
high ADJ O
levels NOUN O
of ADP O
Ginir PROPN B-AC
RNA NOUN O
, PUNCT O
and CCONJ O
( PUNCT O
v X O
) PUNCT O
interference NOUN O
of ADP O
Cep112 PROPN B-AC
– SYM O
Brca1 NOUN B-AC
interaction NOUN O
due ADP O
to ADP O
increased VERB O
presence NOUN O
of ADP O
Ginir PROPN B-AC
RNA NOUN O
causes VERB O
replicative ADJ O
stress NOUN O
and CCONJ O
induces VERB O
mitotic ADJ O
dysregulation NOUN O
, PUNCT O
causing VERB O
genomic ADJ O
instability NOUN O
, PUNCT O
and CCONJ O
thereby ADV O
propels VERB O
cells NOUN O
towards ADP O
malignant ADJ O
transformation NOUN O
. PUNCT O

Tumors NOUN O
were AUX O
staged VERB O
based VERB O
upon SCONJ O
the DET O
sixth ADJ O
or CCONJ O
seventh ADJ O
tumor NOUN B-LF
– PUNCT I-LF
node NOUN I-LF
– PUNCT I-LF
metastasis NOUN I-LF
( PUNCT O
TNM PROPN B-AC
) PUNCT O
classification NOUN O
of ADP O
the DET O
Union PROPN B-LF
for ADP I-LF
International PROPN I-LF
Cancer PROPN I-LF
Control PROPN I-LF
( PUNCT O
UICC PROPN B-AC
) PUNCT O
. PUNCT O
Operative ADJ O
time NOUN O
was AUX O
calculated VERB O
from ADP O
the DET O
electronic ADJ O
record NOUN O
on ADP O
the DET O
anesthesia NOUN O
machine NOUN O
from ADP O
the DET O
start NOUN O
of ADP O
creating VERB O
a DET O
pneumoperitoneum NOUN O
to ADP O
the DET O
end NOUN O
when SCONJ O
the DET O
abdominal ADJ O
incision NOUN O
being AUX O
sutured VERB O
. PUNCT O

Cataract NOUN O
extraction NOUN O
and CCONJ O
intraocular ADJ B-LF
lens NOUN I-LF
( PUNCT O
IOL PROPN B-AC
) PUNCT O
implantation NOUN O
could AUX O
thus ADV O
increase VERB O
the DET O
amount NOUN O
of ADP O
blue ADJ O
light NOUN O
that PRON O
reaches VERB O
retina NOUN O
. PUNCT O

The DET O
geometric ADJ O
mean ADJ O
parasite NOUN O
density NOUN O
at ADP O
baseline NOUN O
was AUX O
26,705 NUM O
/ NUM O
μl NOUN O
( PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
[ PUNCT O
CI NOUN B-AC
] PUNCT O
: PUNCT O
20,385 NUM O
to PART O
34,985 NUM O
) PUNCT O
. PUNCT O

GCN PROPN B-AC
, PUNCT O
gene NOUN B-LF
coexpression NOUN I-LF
network NOUN I-LF
; PUNCT O
MPS PROPN B-AC
, PUNCT O
mononuclear ADJ B-LF
phagocyte NOUN I-LF
system NOUN I-LF
; PUNCT O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT O
scRNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT O
single ADJ B-LF
- PUNCT I-LF
cell NOUN I-LF
RNA NOUN I-LF
- PUNCT I-LF
seq NOUN I-LF
. PUNCT O

On ADP O
the DET O
other ADJ O
hand NOUN O
, PUNCT O
enzymatic ADJ O
conversion NOUN O
of ADP O
EPA PROPN B-AC
and CCONJ O
DHA PROPN B-AC
can AUX O
yield VERB O
highly ADV O
potent ADJ O
lipid NOUN O
mediators NOUN O
: PUNCT O
CYP PROPN B-AC
catalyzed VERB O
epoxidation NOUN O
leads VERB O
e.g. X O
to ADP O
anti ADJ O
- ADJ O
arrhythmic ADJ O
acting VERB O
17(18)-epoxy NOUN B-LF
eicosatetraenoic NOUN I-LF
acid NOUN I-LF
( PUNCT O
EpETE PROPN B-AC
) PUNCT O
from ADP O
EPA PROPN B-AC
and CCONJ O
19(20)-epoxy NOUN B-LF
docosapentaenoic NOUN I-LF
acid NOUN I-LF
( PUNCT O
EpDPE PROPN B-AC
) PUNCT O
from ADP O
DHA PROPN B-AC
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

Nevertheless ADV O
, PUNCT O
the DET O
SGBIIA PROPN B-AC
cohort NOUN O
exhibited VERB O
a DET O
lower ADJ O
DM NOUN B-AC
risk NOUN O
after SCONJ O
we PRON O
adjusted ADJ O
for ADP O
the DET O
comorbidities NOUN O
of ADP O
hypertension NOUN O
, PUNCT O
hyperlipidemia NOUN O
, PUNCT O
and CCONJ O
coronary ADJ O
artery NOUN O
disease NOUN O
( PUNCT O
adjusted ADJ B-LF
hazard NOUN I-LF
ratio NOUN I-LF
( PUNCT O
aHR NOUN B-AC
): PUNCT O
0.56 NUM O
, PUNCT O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
): PUNCT O
0.40–0.78 NUM O
) PUNCT O
. PUNCT O

Relatively ADV O
high ADJ O
concentrations NOUN O
of ADP O
phthalates NOUN O
were AUX O
reported VERB O
for ADP O
M. PROPN O
edulis PROPN O
and CCONJ O
C. PROPN O
edule PROPN O
, PUNCT O
26.36 NUM O
and CCONJ O
52.36 NUM O
ng NOUN O
g-1 NOUN O
, PUNCT O
with SCONJ O
concentrations NOUN O
of ADP O
polycyclic ADJ B-LF
aromatic ADJ I-LF
hydrocarbons NOUN I-LF
( PUNCT O
PAHs PROPN B-AC
) PUNCT O
, PUNCT O
polybrominated ADJ B-LF
diphenyl NOUN I-LF
ethers NOUN I-LF
( PUNCT O
PBDEs PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
polychlorinated ADJ B-LF
biphenyls NOUN I-LF
( PUNCT O
PCBs PROPN B-AC
) PUNCT O
substantially ADV O
lower ADJ O
for ADP O
both DET O
organisms NOUN O
[ PUNCT O
54 NUM O
] PUNCT O
. PUNCT O

We PRON O
have AUX O
previously ADV O
shown VERB O
that SCONJ O
activation NOUN O
of ADP O
the DET O
ligand NOUN O
- PUNCT O
dependent ADJ O
transcription NOUN O
factor NOUN O
aryl NOUN B-LF
hydrocarbon NOUN I-LF
receptor NOUN I-LF
( PUNCT O
AhR PROPN B-AC
) PUNCT O
by ADP O
the DET O
environmental ADJ O
pollutant NOUN O
2,3,7,8 NUM B-LF
- PUNCT I-LF
tetrachlorodibenzo NOUN I-LF
- PUNCT I-LF
p NOUN I-LF
- PUNCT I-LF
dioxin NOUN I-LF
( PUNCT O
TCDD PROPN B-AC
) PUNCT O
affects VERB O
both CCONJ O
oral ADJ O
tolerance NOUN O
and CCONJ O
food NOUN O
allergy NOUN O
. PUNCT O

Direction ADJ B-LF
selective ADJ I-LF
ganglion NOUN I-LF
cells NOUN I-LF
( PUNCT O
DSGCs NOUN B-AC
) PUNCT O
in ADP O
the DET O
retina NOUN O
are AUX O
important ADJ O
in ADP O
the DET O
processing NOUN O
of ADP O
motion NOUN O
information NOUN O
. PUNCT O

BMI PROPN B-AC
= PUNCT O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT O
CI PROPN B-AC
= PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT O
COR PROPN B-AC
= PUNCT O
crude ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT O
AOR NOUN B-AC
= PUNCT O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT O
TC PROPN B-AC
= PUNCT O
total ADJ B-LF
cholesterol NOUN I-LF
. PUNCT O

GM PROPN O
, PUNCT O
geometric ADJ O
mean NOUN O
; PUNCT O
GSD PROPN O
, PUNCT O
geometric ADJ O
standard ADJ O
deviation NOUN O
; PUNCT O
LOD PROPN B-AC
, PUNCT O
limit NOUN B-LF
of ADP I-LF
detection NOUN I-LF
. PUNCT O

Interestingly ADV O
, PUNCT O
the DET O
increased VERB O
glucose NOUN O
levels NOUN O
stress VERB O
the DET O
pancreatic ADJ O
islets NOUN O
and CCONJ O
insulin NOUN O
- PUNCT O
sensitive ADJ O
tissues NOUN O
, PUNCT O
leading VERB O
to ADP O
hyperproduction NOUN O
of ADP O
IL NOUN O
- PUNCT O
β NOUN O
via ADP O
nucleotide NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
oligomerization NOUN I-LF
domain NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
receptors- NOUN I-LF
, PUNCT I-LF
leucine NOUN I-LF
- PUNCT I-LF
rich ADJ I-LF
repeat- NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
pyrin NOUN I-LF
domain NOUN I-LF
– PUNCT I-LF
containing VERB I-LF
3 NUM I-LF
( PUNCT O
NLRP3 NOUN B-AC
) PUNCT O
inflammasome NOUN O
[ PUNCT O
4,5 NUM O
] PUNCT O
. PUNCT O

HO PROPN B-AC
, PUNCT O
High PROPN O
Nutrient NOUN O
Old PROPN O
Breeding PROPN O
treatment NOUN O
; PUNCT O
HY PROPN B-AC
, PUNCT O
High PROPN O
Nutrient NOUN O
Young PROPN O
Breeding PROPN O
treatment NOUN O
; PUNCT O
KLDC PROPN B-AC
, PUNCT O
Kullback PROPN B-LF
- PUNCT I-LF
Leibler PROPN I-LF
discrepancy NOUN I-LF
calibration NOUN I-LF
; PUNCT O
LO PROPN B-AC
, PUNCT O
Low PROPN O
Nutrient NOUN O
Old PROPN O
Breeding PROPN O
treatment NOUN O
; PUNCT O
LY PROPN B-AC
, PUNCT O
Low PROPN O
Nutrient NOUN O
Young PROPN O
Breeding PROPN O
treatment NOUN O
. PUNCT O

The DET O
current ADJ O
acute ADJ B-LF
kidney NOUN I-LF
injury NOUN I-LF
( PUNCT O
AKI PROPN B-AC
) PUNCT O
risk NOUN O
prediction NOUN O
model NOUN O
for ADP O
patients NOUN O
undergoing VERB O
percutaneous ADJ B-LF
coronary ADJ I-LF
intervention NOUN I-LF
( PUNCT O
PCI PROPN B-AC
) PUNCT O
from ADP O
the DET O
American PROPN B-LF
College PROPN I-LF
of ADP I-LF
Cardiology PROPN I-LF
( PUNCT O
ACC PROPN B-AC
) PUNCT O
National PROPN B-LF
Cardiovascular PROPN I-LF
Data PROPN I-LF
Registry PROPN I-LF
( PUNCT O
NCDR PROPN B-AC
) PUNCT O
employed VERB O
regression NOUN O
techniques NOUN O
. PUNCT O

BMP11 PROPN B-AC
, PUNCT O
Bone PROPN B-LF
Morphogenetic PROPN I-LF
Protein PROPN I-LF
11 NUM I-LF
; PUNCT O
RT NOUN O
- PUNCT O
PCR PROPN O
, PUNCT O
reverse ADJ O
transcription NOUN O
polymerase NOUN O
chain NOUN O
reaction NOUN O
; PUNCT O
Ubx PROPN B-AC
, PUNCT O
Ultrabithorax NOUN B-LF
. PUNCT O

For ADP O
the DET O
first ADJ O
time NOUN O
, PUNCT O
we PRON O
aimed VERB O
to PART O
assess VERB O
the DET O
stability NOUN O
of ADP O
21 NUM B-LF
- PUNCT I-LF
deoxycortisol NOUN I-LF
( PUNCT O
21Deox NOUN B-AC
) PUNCT O
, PUNCT O
11 NUM B-LF
- PUNCT I-LF
deoxycortisol NOUN I-LF
( PUNCT O
11Deox NOUN B-AC
) PUNCT O
, PUNCT O
4 NUM B-LF
- PUNCT I-LF
androstenedione NOUN I-LF
( PUNCT O
4AD NOUN B-AC
) PUNCT O
, PUNCT O
17 NUM B-LF
- PUNCT I-LF
hydroxyprogesterone NOUN I-LF
( PUNCT O
17OHP NOUN B-AC
) PUNCT O
and CCONJ O
cortisol NOUN B-LF
( PUNCT O
Cort NOUN B-AC
) PUNCT O
, PUNCT O
diagnostic ADJ O
for ADP O
CAH PROPN B-AC
, PUNCT O
in ADP O
dried VERB B-LF
blood NOUN I-LF
spots NOUN I-LF
( PUNCT O
DBSs PROPN B-AC
) PUNCT O
during ADP O
a DET O
1 NUM O
year NOUN O
storage NOUN O
at ADP O
different ADJ O
temperatures NOUN O
. PUNCT O

Considering VERB O
the DET O
expression NOUN O
of ADP O
DIP2A PROPN B-AC
in ADP O
embryonic ADJ O
and CCONJ O
early ADJ O
postnatal ADJ O
days NOUN O
, PUNCT O
we PRON O
speculate VERB O
that SCONJ O
DIP2A PROPN B-AC
also ADV O
affects VERB O
other ADJ O
processes NOUN O
of ADP O
neuronal ADJ O
development NOUN O
, PUNCT O
such ADJ O
as ADP O
the DET O
function NOUN O
of ADP O
the DET O
autism NOUN O
- NOUN O
associated VERB O
gene NOUN O
phosphatidylinositol NOUN B-LF
3,4,5 NUM I-LF
- NOUN I-LF
trisphosphate NOUN I-LF
- NOUN I-LF
dependent ADJ I-LF
Rac PROPN I-LF
exchanger NOUN I-LF
1 NUM I-LF
( PUNCT O
P PROPN B-AC
- NOUN B-AC
Rex1 PROPN B-AC
) PUNCT O
in ADP O
synaptic ADJ O
transmission NOUN O
and CCONJ O
neuronal ADJ O
migration NOUN O
[ X O
69,70 NUM O
] PUNCT O
. PUNCT O

Metabolite NOUN O
analysis NOUN O
was AUX O
conducted VERB O
on ADP O
a DET O
thermal ADJ B-LF
desorption NOUN I-LF
- PUNCT O
gas NOUN B-LF
chromatography NOUN I-LF
time NOUN O
- PUNCT O
of ADP O
- PUNCT O
flight NOUN O
mass NOUN O
spectrometer NOUN O
( PUNCT O
GC PROPN B-AC
- PUNCT O
TOF PROPN O
- PUNCT O
MS PROPN O
) PUNCT O
platform NOUN O
( PUNCT O
Unity PROPN O
II PROPN O
TD PROPN B-AC
with ADP O
UltrA PROPN O
autosampler NOUN O
, PUNCT O
Markes PROPN O
International PROPN O
, PUNCT O
and CCONJ O
Micromass PROPN O
GCT PROPN O
Premier PROPN O
, PUNCT O
Waters PROPN O
Corp PROPN O
, PUNCT O
Manchester PROPN O
, PUNCT O
UK PROPN O
) PUNCT O
. PUNCT O
Prior ADV O
to ADP O
desorption NOUN O
, PUNCT O
100 NUM O
μl NOUN O
of ADP O
an DET O
internal ADJ B-LF
standard NOUN I-LF
( PUNCT O
IS PROPN B-AC
; PUNCT O
1 NUM O
ppmV NOUN O
4 NUM O
- PUNCT O
bromofluorobenzene NOUN O
in ADP O
N2 PROPN O
; PUNCT O
Thames PROPN O
Restek PROPN O
, PUNCT O
Bucks PROPN O
, PUNCT O
UK PROPN O
) PUNCT O
was AUX O
loaded VERB O
onto ADP O
each DET O
tube NOUN O
. PUNCT O

Briefly ADV O
, PUNCT O
the DET O
three NUM O
dilutions NOUN O
of ADP O
Essential PROPN B-LF
Iodine PROPN I-LF
Drops PROPN I-LF
( PUNCT O
EID PROPN B-AC
) PUNCT O
containing VERB O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
virus NOUN O
solution NOUN O
( PUNCT O
1:1 NUM O
; PUNCT O
2:1 NUM O
and CCONJ O
3:1 NUM O
) PUNCT O
were AUX O
tested VERB O
in ADP O
triplicates NOUN O
for ADP O
virucidal ADJ O
activity NOUN O
as SCONJ O
described VERB O
by ADP O
Pelletier PROPN O
and CCONJ O
colleagues NOUN O
[ PUNCT O
12 NUM O
] PUNCT O
. PUNCT O

Finally ADV O
, PUNCT O
we PRON O
confirmed VERB O
the DET O
impact NOUN O
of ADP O
HF PROPN B-AC
diet NOUN O
on ADP O
striatal ADJ O
DA NOUN B-AC
D2 NOUN B-LF
receptor NOUN I-LF
( PUNCT O
D2R PROPN B-AC
) PUNCT O
availability NOUN O
using VERB O
[ X O
18F]fallypride X O
positron NOUN B-LF
emission NOUN I-LF
tomography NOUN I-LF
( PUNCT O
PET NOUN B-AC
) PUNCT O
. PUNCT O

Hospital PROPN B-LF
Based PROPN I-LF
Health PROPN I-LF
Technology PROPN I-LF
Assessment PROPN I-LF
( PUNCT O
HB PROPN B-AC
- PUNCT B-AC
HTA PROPN B-AC
) PUNCT O
is AUX O
a DET O
new ADJ O
policy NOUN O
implemented VERB O
in ADP O
Poland PROPN O
to ADP O
allow VERB O
for ADP O
a DET O
more ADV O
practical ADJ O
and CCONJ O
contextualized ADJ O
assessment NOUN O
related VERB O
to ADP O
the DET O
use NOUN O
of ADP O
specific ADJ O
medical ADJ O
procedures NOUN O
, PUNCT O
devices NOUN O
, PUNCT O
or CCONJ O
equipment NOUN O
. PUNCT O

We PRON O
found VERB O
that SCONJ O
dietary ADJ O
intervention NOUN O
with ADP O
test NOUN O
food NOUN O
altered VERB O
urine NOUN O
characteristic ADJ O
such ADJ O
that SCONJ O
the DET O
RSS NOUN B-AC
for ADP O
struvite NOUN O
crystals NOUN O
was AUX O
decreased VERB O
( PUNCT O
P NOUN O
= SYM O
0.03 NUM O
) PUNCT O
and CCONJ O
there PRON O
tended VERB O
to ADP O
be AUX O
increased VERB O
resistance NOUN O
to ADP O
oxalate NOUN O
crystal NOUN O
formation NOUN O
as SCONJ O
determined VERB O
by ADP O
the DET O
calcium NOUN B-LF
oxalate NOUN I-LF
titrimetric ADJ I-LF
test NOUN I-LF
( PUNCT O
COT NOUN B-AC
; PUNCT O
P NOUN O
= SYM O
0.06 NUM O
) PUNCT O
. PUNCT O

The DET O
model NOUN O
was AUX O
implemented VERB O
by ADP O
a DET O
set NOUN O
of ADP O
ordinary ADJ B-LF
differential ADJ I-LF
equations NOUN I-LF
( PUNCT O
ODEs NOUN B-AC
) PUNCT O
[ X O
18 NUM O
] PUNCT O
, PUNCT O
an DET O
approach NOUN O
successfully ADV O
used VERB O
to ADP O
describe VERB O
the DET O
cell NOUN O
cycle NOUN O
control NOUN O
in ADP O
budding VERB O
yeast NOUN O
[ X O
19,20 NUM O
] PUNCT O
and CCONJ O
the DET O
cellular ADJ O
response NOUN O
of ADP O
yeast NOUN O
to ADP O
hyperosmotic ADJ O
shock NOUN O
[ X O
21 NUM O
] PUNCT O
. PUNCT O

For ADP O
daytime NOUN O
physical ADJ O
activity NOUN O
, PUNCT O
FSS PROPN B-AC
and CCONJ O
sleep NOUN O
efficiency NOUN O
, PUNCT O
the DET O
mean NOUN O
change NOUN O
and CCONJ O
the DET O
95 NUM O
% NOUN O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT O
CI NOUN B-AC
) PUNCT O
between ADP O
baseline NOUN O
( PUNCT O
Day PROPN O
1 NUM O
) PUNCT O
and CCONJ O
Day PROPN O
28 NUM O
, PUNCT O
Day PROPN O
84 NUM O
and CCONJ O
12 NUM O
weeks NOUN O
post NOUN O
- NOUN O
treatment NOUN O
( PUNCT O
Day PROPN O
168 NUM O
) PUNCT O
was AUX O
calculated VERB O
. PUNCT O

Furthermore ADV O
, PUNCT O
our PRON O
cryo NOUN B-LF
- PUNCT I-LF
electron NOUN I-LF
microscopy NOUN I-LF
( PUNCT O
cryo NOUN B-AC
- PUNCT B-AC
EM NOUN B-AC
) PUNCT O
structure NOUN O
of ADP O
the DET O
50S·ObgE·GMPPNP PROPN B-AC
complex NOUN O
indicates VERB O
that SCONJ O
the DET O
evolutionarily ADV O
conserved VERB O
N NOUN B-LF
- PUNCT I-LF
terminal NOUN I-LF
domain NOUN I-LF
( PUNCT O
NTD PROPN B-AC
) PUNCT O
of ADP O
ObgE PROPN B-AC
is AUX O
a DET O
tRNA NOUN O
structural ADJ O
mimic NOUN O
, PUNCT O
with ADP O
specific ADJ O
interactions NOUN O
with ADP O
peptidyl NOUN O
- PUNCT O
transferase NOUN O
center NOUN O
, PUNCT O
displaying VERB O
a DET O
marked ADJ O
resemblance NOUN O
to ADP O
Class PROPN O
I NUM O
release NOUN O
factors NOUN O
. PUNCT O

Cardiovascular ADJ O
risk NOUN O
factors NOUN O
included VERB O
BMI NOUN O
z NOUN O
- PUNCT O
score NOUN O
, PUNCT O
waist NOUN O
circumference NOUN O
, PUNCT O
blood NOUN O
pressure NOUN O
( PUNCT O
z NOUN O
- PUNCT O
score NOUN O
) PUNCT O
and CCONJ O
estimated VERB O
cardiorespiratory ADJ B-LF
fitness NOUN I-LF
( PUNCT O
CRF NOUN B-AC
) PUNCT O
as SCONJ O
measured VERB O
with ADP O
the DET O
20 NUM O
meter NOUN O
shuttle NOUN O
run NOUN O
test NOUN O
. PUNCT O

To ADP O
this DET O
end NOUN O
, PUNCT O
we PRON O
used VERB O
human ADJ O
functional ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT O
fMRI NOUN B-AC
) PUNCT O
combined VERB O
with ADP O
psychophysics NOUN O
. PUNCT O

Sensitivity NOUN O
of ADP O
qPCR NOUN B-AC
was AUX O
approximately ADV O
82 NUM O
% PUNCT O
and CCONJ O
Negative ADJ B-LF
Predictive ADJ I-LF
Value NOUN I-LF
( PUNCT O
NPV PROPN B-AC
) PUNCT O
79 NUM O
% PUNCT O
. PUNCT O

The DET O
lipid NOUN O
content NOUN O
may AUX O
vary VERB O
from ADP O
1 NUM O
to ADP O
40 NUM O
% NOUN O
of ADP O
dry ADJ B-LF
matter NOUN I-LF
( PUNCT O
DM NOUN B-AC
) PUNCT O
in ADP O
certain ADJ O
strains NOUN O
, PUNCT O
and CCONJ O
under ADP O
special ADJ O
culture NOUN O
conditions NOUN O
the DET O
level NOUN O
can AUX O
go VERB O
up ADP O
to ADP O
85 NUM O
% NOUN O
[ PUNCT O
5 NUM O
] PUNCT O
. PUNCT O

Here ADV O
, PUNCT O
we PRON O
reconstituted VERB O
the DET O
interaction NOUN O
of ADP O
Atg11 PROPN O
with ADP O
Atg9 NOUN B-LF
- PUNCT I-LF
proteoliposomes NOUN I-LF
( PUNCT O
Atg9 NOUN B-AC
- PUNCT B-AC
PLs NOUN O
) PUNCT O
from ADP O
purified VERB O
components NOUN O
on ADP O
model NOUN O
membranes NOUN O
in ADP O
vitro ADJ O
. PUNCT O

EHR PROPN B-AC
, PUNCT O
electronic ADJ B-LF
health NOUN I-LF
record NOUN I-LF
; PUNCT O
LDL NOUN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
. PUNCT O

Similar ADJ O
structures NOUN O
, PUNCT O
including VERB O
peroxisome NOUN O
- PUNCT O
localized VERB O
Rab5B PROPN O
- PUNCT O
containing VERB O
membranes NOUN O
, PUNCT O
were AUX O
visible ADJ O
when SCONJ O
N. PROPN O
benthamiana PROPN O
plants NOUN O
were AUX O
infected VERB O
with ADP O
Cucumber PROPN B-LF
necrosis NOUN I-LF
virus NOUN I-LF
( PUNCT O
CNV PROPN B-AC
, PUNCT O
a DET O
very ADV O
close ADJ O
relative NOUN O
of ADP O
TBSV PROPN B-AC
) PUNCT O
( PUNCT O
Fig PROPN O
2B NUM O
) PUNCT O
. PUNCT O
As SCONJ O
expected VERB O
, PUNCT O
uninfected ADJ O
N. PROPN O
benthamiana PROPN O
plants NOUN O
did AUX O
not PART O
show VERB O
co NOUN O
- PUNCT O
localization NOUN O
of ADP O
the DET O
peroxisomal ADJ O
GFP PROPN B-AC
- PUNCT O
SKL PROPN O
and CCONJ O
the DET O
early ADJ O
endosomal ADJ O
AtRab5b PROPN O
and CCONJ O
also ADV O
lacked VERB O
aggregated VERB O
peroxisomes NOUN O
( PUNCT O
Fig PROPN O
2B NUM O
, PUNCT O
the DET O
lowest ADJ O
panel NOUN O
) PUNCT O
. PUNCT O

The DET O
human ADJ B-LF
umbilical ADJ I-LF
vein NOUN I-LF
endothelial ADJ I-LF
cells NOUN I-LF
( PUNCT O
HUVEC PROPN B-AC
) PUNCT O
used VERB O
in ADP O
the DET O
adhesion NOUN O
studies NOUN O
were AUX O
harvested VERB O
from ADP O
umbilical ADJ O
cords NOUN O
by ADP O
treating VERB O
them PRON O
with ADP O
collagenase NOUN O
. PUNCT O

The DET O
other ADJ O
measured VERB O
plasma NOUN O
interleukins NOUN B-LF
( PUNCT O
IL-2 NOUN B-AC
, PUNCT O
IL-5 NOUN B-AC
, PUNCT O
IL-6 NOUN B-AC
, PUNCT O
IL-10 NOUN B-AC
, PUNCT O
IL-13 NOUN B-AC
, PUNCT O
IL-21 NOUN B-AC
, PUNCT O
IL-22 NOUN B-AC
, PUNCT O
IL-27 NOUN B-AC
, PUNCT O
INF NOUN O
- PUNCT O
γ NOUN O
or CCONJ O
TNF NOUN B-AC
- PUNCT O
α NOUN O
) PUNCT O
were AUX O
all PRON O
similar ADJ O
in ADP O
Rgp44 NOUN O
- PUNCT O
immunized VERB O
mice NOUN O
compared VERB O
to ADP O
the DET O
saline ADJ O
group NOUN O
. PUNCT O

SR NOUN B-AC
- PUNCT B-AC
μCT NOUN B-AC
, PUNCT O
synchrotron NOUN B-LF
radiation NOUN I-LF
microcomputed VERB I-LF
tomography NOUN I-LF

The DET O
average NOUN O
of ADP O
three NUM O
cardiac ADJ O
cycles NOUN O
was AUX O
used VERB O
for ADP O
measurements NOUN O
of ADP O
cardiac ADJ O
dimensions NOUN O
, PUNCT O
and CCONJ O
left VERB B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
( PUNCT O
LVEF PROPN B-AC
) PUNCT O
. PUNCT O

Significance NOUN O
was AUX O
determined VERB O
by ADP O
one NUM O
- PUNCT O
way NOUN O
ANOVA NOUN O
with ADP O
Tukey PROPN O
- PUNCT O
Kramer PROPN O
post NOUN O
- PUNCT O
test NOUN O
. PUNCT O
* PUNCT O
represents VERB O
p NOUN O
≤ ADP O
0.05 NUM O
; PUNCT O
* PUNCT O
* PUNCT O
represents VERB O
p NOUN O
≤ ADP O
0.01 NUM O
. PUNCT O
( PUNCT O
F NOUN O
) PUNCT O
Projection NOUN O
of ADP O
signaling NOUN O
data NOUN O
from ADP O
vehicle- NOUN O
and CCONJ O
rapamycin NOUN O
- PUNCT O
treated VERB O
samples NOUN O
onto ADP O
a DET O
partial ADJ B-LF
least ADJ I-LF
squares NOUN I-LF
regression NOUN I-LF
( PUNCT O
PLSR PROPN B-AC
) PUNCT O
model NOUN O
built VERB O
from ADP O
untreated ADJ O
samples NOUN O
. PUNCT O

For ADP O
the DET O
molecular ADJ O
analysis NOUN O
at ADP O
the DET O
Hlx1 NOUN O
hotspot NOUN O
, PUNCT O
mice NOUN O
heterozygous ADJ O
for ADP O
the DET O
B10 PROPN O
and CCONJ O
CAST PROPN O
alleles NOUN O
at ADP O
the DET O
chromosome NOUN B-LF
1 NUM O
Hlx1 NOUN O
hotspot NOUN O
and CCONJ O
carrying VERB O
the DET O
appropriate ADJ O
genotype NOUN O
on ADP O
Chr PROPN B-AC
17 NUM O
have AUX O
been AUX O
generated VERB O
as SCONJ O
follows VERB O
: PUNCT O
CASTxR209 PROPN O
F1 PROPN O
hybrids NOUN O
were AUX O
generated VERB O
and CCONJ O
crossed VERB O
with ADP O
B10 PROPN O
. PUNCT O

Dox PROPN B-AC
, PUNCT O
doxycycline NOUN B-LF
; PUNCT O
LATS1 PROPN B-AC
, PUNCT O
large ADJ B-LF
tumor NOUN I-LF
suppressor NOUN I-LF
kinase NOUN I-LF
1 NUM I-LF
; PUNCT O
MST1 PROPN B-AC
, PUNCT O
mammalian ADJ B-LF
sterile ADJ I-LF
20 NUM I-LF
- PUNCT I-LF
like ADJ I-LF
kinase NOUN I-LF
1 NUM I-LF
; PUNCT O
PPM1A PROPN B-AC
, PUNCT O
protein NOUN B-LF
phosphatase NOUN I-LF
magnesium NOUN I-LF
- PUNCT I-LF
dependent ADJ I-LF
1A NOUN I-LF
; PUNCT O
TAZ PROPN B-AC
, PUNCT O
transcriptional ADJ B-LF
coactivator NOUN I-LF
with ADP I-LF
PDZ NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
motif NOUN I-LF
; PUNCT O
TEAD PROPN B-AC
, PUNCT O
transcriptional ADJ B-LF
enhanced ADJ I-LF
associate NOUN I-LF
domain NOUN I-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
; PUNCT O
YAP PROPN B-AC
, PUNCT O
Yes NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
. PUNCT O

At ADP O
E19 PROPN O
, PUNCT O
birth NOUN O
weight NOUN O
, PUNCT O
lung NOUN O
weight NOUN O
and CCONJ O
lung NOUN B-LF
weight NOUN I-LF
/ SYM I-LF
birth NOUN I-LF
weight NOUN I-LF
ratio NOUN I-LF
( PUNCT O
LW NOUN B-AC
/ SYM B-AC
BW NOUN B-AC
ratio NOUN B-AC
) PUNCT O
were AUX O
significantly ADV O
lower ADJ O
in ADP O
the DET O
pups NOUN O
born VERB O
of ADP O
VDL PROPN B-AC
mothers NOUN O
than ADP O
in ADP O
the DET O
controls NOUN O
. PUNCT O

The DET O
Intra ADJ O
- ADJ O
class NOUN O
Correlation NOUN O
Coefficient NOUN O
( PUNCT O
ICC PROPN B-AC
) PUNCT O
, PUNCT O
Median ADJ B-LF
Odds NOUN I-LF
Ratio NOUN I-LF
( PUNCT O
MOR PROPN B-AC
) PUNCT O
, PUNCT O
Proportional ADJ B-LF
Change NOUN I-LF
in ADP I-LF
Variance NOUN I-LF
( PUNCT O
PCV PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
deviance NOUN O
( PUNCT O
-2LL NOUN O
) PUNCT O
were AUX O
used VERB O
for ADP O
model NOUN O
comparison NOUN O
and CCONJ O
for ADP O
checking VERB O
model NOUN O
fitness NOUN O
. PUNCT O

We PRON O
show VERB O
that SCONJ O
amino ADJ O
- PUNCT O
terminal ADJ O
tripeptides NOUN O
of ADP O
several ADJ O
secreted VERB O
proteins NOUN O
bind VERB O
to ADP O
transmembrane NOUN O
cargo NOUN O
receptor NOUN O
, PUNCT O
surfeit NOUN B-LF
locus NOUN I-LF
protein NOUN I-LF
4 NUM I-LF
( PUNCT O
Surf4 PROPN B-AC
) PUNCT O
, PUNCT O
for ADP O
increased VERB O
ER NOUN B-AC
- PUNCT O
trafficking NOUN O
efficiency NOUN O
. PUNCT O

We PRON O
identified VERB O
and CCONJ O
excluded VERB O
women NOUN O
with ADP O
prior ADJ O
CKD PROPN B-AC
, PUNCT O
CVD PROPN B-AC
, PUNCT O
hypertension NOUN O
, PUNCT O
or CCONJ O
diabetes NOUN O
through ADP O
a DET O
linkage NOUN O
with ADP O
the DET O
NPR PROPN B-AC
using VERB O
the DET O
international ADJ B-LF
classification NOUN I-LF
of ADP I-LF
diseases NOUN I-LF
( PUNCT O
ICD PROPN B-AC
) PUNCT O
codes NOUN O
( PUNCT O
S1 PROPN O
Table PROPN O
) PUNCT O
. PUNCT O

We PRON O
next ADV O
conducted VERB O
an DET O
unbiased ADJ O
, PUNCT O
data NOUN O
- PUNCT O
driven VERB O
analysis NOUN O
to ADP O
prioritize VERB O
damaging ADJ O
variants NOUN O
most ADV O
likely ADJ O
to ADP O
contribute VERB O
to ADP O
the DET O
risk NOUN O
of ADP O
developing VERB O
an DET O
ED NOUN B-AC
. PUNCT O
First ADV O
, PUNCT O
we PRON O
identified VERB O
all DET O
genes NOUN O
mentioned VERB O
in ADP O
three NUM O
or CCONJ O
more ADJ O
papers NOUN O
in ADP O
the DET O
PubMed PROPN O
database NOUN O
that PRON O
mention VERB O
either CCONJ O
" PUNCT O
appetite NOUN O
" PUNCT O
or CCONJ O
" PUNCT O
eating NOUN B-LF
disorder NOUN I-LF
" PUNCT O
( PUNCT O
S2 PROPN O
Table NOUN O
) PUNCT O
. PUNCT O

DALY PROPN B-AC
, PUNCT O
disability NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
year NOUN I-LF
; PUNCT O
GBD PROPN B-AC
, PUNCT O
Global PROPN B-LF
Burden PROPN I-LF
of ADP I-LF
Disease PROPN I-LF
Study PROPN I-LF
. PUNCT O

Analyses NOUN O
were AUX O
carried VERB O
out ADP O
for ADP O
all DET O
participants NOUN O
randomised VERB O
to ADP O
the DET O
study NOUN O
( PUNCT O
ITT NOUN B-AC
set NOUN O
, PUNCT O
n NOUN O
= SYM O
573 NUM O
) PUNCT O
and CCONJ O
for ADP O
the DET O
per ADP B-LF
protocol NOUN I-LF
set NOUN I-LF
( PUNCT O
PPS NOUN B-AC
, PUNCT O
n NOUN O
= SYM O
331 NUM O
) PUNCT O
. PUNCT O

In ADP O
a DET O
cover NOUN B-LF
crop NOUN I-LF
( PUNCT O
CC PROPN B-AC
) PUNCT O
experiment NOUN O
established VERB O
in ADP O
2007 NUM O
and CCONJ O
repeated VERB O
at ADP O
an DET O
adjacent ADJ O
site NOUN O
in ADP O
2008 NUM O
, PUNCT O
we PRON O
evaluated VERB O
the DET O
medium ADJ O
- PUNCT O
term NOUN O
impact NOUN O
of ADP O
CC PROPN B-AC
( PUNCT O
no DET B-LF
cover NOUN I-LF
crop NOUN I-LF
control NOUN I-LF
( PUNCT O
no DET B-AC
- PUNCT B-AC
CC PROPN B-AC
) PUNCT O
, PUNCT O
oat NOUN O
( PUNCT O
Avena PROPN O
sativa PROPN O
L. PROPN O
) PUNCT O
, PUNCT O
oilseed NOUN B-LF
radish NOUN I-LF
( PUNCT O
OSR PROPN B-AC
, PUNCT O
Raphanus PROPN O
sativus PROPN O
L. PROPN O
var NOUN O
. PUNCT O
oleoferus PROPN O
Metzg PROPN O
. PUNCT O

SD NOUN B-AC
, PUNCT O
standard ADJ B-LF
deviation NOUN I-LF

DRS PROPN B-AC
, PUNCT O
Durham PROPN B-LF
Risk NOUN I-LF
Score NOUN I-LF
. PUNCT O

APC PROPN B-AC
, PUNCT O
antigen NOUN B-LF
- PUNCT I-LF
presenting VERB I-LF
cell NOUN I-LF
; PUNCT O
CNS PROPN B-AC
, PUNCT O
central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
; PUNCT O
DO PROPN B-AC
, PUNCT O
H2 NOUN O
- PUNCT O
O NOUN O
; PUNCT O
KO PROPN B-AC
, PUNCT O
knockout NOUN B-LF
; PUNCT O
MOG PROPN B-AC
, PUNCT O
myelin NOUN B-LF
oligodendrocyte NOUN I-LF
glycoprotein NOUN I-LF
. PUNCT O

International PROPN O
funding NOUN O
, PUNCT O
including VERB O
that PRON O
from ADP O
governments NOUN O
, PUNCT O
such ADJ O
as ADP O
from ADP O
PMI PROPN B-AC
, PUNCT O
the DET O
United PROPN O
Kingdom PROPN O
’s PART O
Department PROPN B-LF
for ADP I-LF
International PROPN I-LF
Development PROPN I-LF
( PUNCT O
DFID PROPN B-AC
) PUNCT O
, PUNCT O
the DET O
Global PROPN O
Fund PROPN O
, PUNCT O
and CCONJ O
others NOUN O
, PUNCT O
accounts VERB O
for ADP O
a DET O
large ADJ O
proportion NOUN O
( PUNCT O
approximately ADV O
68 NUM O
% NOUN O
[ NUM O
5 NUM O
] PUNCT O
) PUNCT O
of ADP O
the DET O
funds NOUN O
available ADJ O
for ADP O
malaria NOUN O
control NOUN O
worldwide ADV O
. PUNCT O

During ADP O
chemotropic ADJ O
interactions NOUN O
, PUNCT O
the DET O
mitogen NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT O
MAPK PROPN B-AC
) PUNCT O
signal NOUN O
transduction NOUN O
protein NOUN O
complex NOUN O
( PUNCT O
NRC-1 PROPN O
, PUNCT O
MEK-2 PROPN O
, PUNCT O
MAK-2 PROPN O
, PUNCT O
and CCONJ O
the DET O
scaffold NOUN O
protein NOUN O
HAM-5 PROPN O
) PUNCT O
assembles VERB O
/ SYM O
disassembles VERB O
at ADP O
the DET O
CAT PROPN B-AC
tip NOUN O
of ADP O
communicating VERB O
germlings NOUN O
with ADP O
perfectly ADV O
out ADP O
of ADP O
phase NOUN O
dynamics NOUN O
to ADP O
SOFT PROPN O
, PUNCT O
a DET O
scaffold NOUN O
protein NOUN O
for ADP O
components NOUN O
of ADP O
the DET O
MAPK PROPN B-AC
cell NOUN O
wall NOUN O
integrity NOUN O
pathway NOUN O
[ PUNCT O
44–48 NUM O
] PUNCT O
. PUNCT O

Incidence NOUN B-LF
rate NOUN I-LF
ratios NOUN I-LF
( PUNCT O
IRRs NOUN B-AC
) PUNCT O
adjusted VERB O
for ADP O
placental ADJ O
malaria NOUN O
infection NOUN O
and CCONJ O
individual ADJ O
malaria NOUN O
exposure NOUN O
. PUNCT O

I.P. NOUN O
, PUNCT O
intraperitoneal ADJ O
; PUNCT O
LEC PROPN B-AC
, PUNCT O
lateral ADJ B-LF
entorhinal ADJ I-LF
cortex NOUN I-LF
; PUNCT O
LFP PROPN B-AC
, PUNCT O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
; PUNCT O
MUA NOUN B-AC
, PUNCT O
multiunit NOUN B-LF
activity NOUN I-LF
; PUNCT O
OB NOUN B-AC
, PUNCT O
olfactory ADJ B-LF
bulb NOUN I-LF
; PUNCT O
RR NOUN B-AC
, PUNCT O
respiration NOUN B-LF
- PUNCT I-LF
related VERB I-LF
rhythm NOUN I-LF
. PUNCT O

With ADP O
the DET O
addition NOUN O
of ADP O
utilities NOUN O
, PUNCT O
the DET O
immediate ADJ O
cystectomy NOUN O
strategy NOUN O
yielded VERB O
an DET O
average ADJ O
QALE NOUN B-AC
of ADP O
12.32 NUM O
y NOUN O
and CCONJ O
remained VERB O
preferred ADJ O
over ADP O
conservative ADJ O
therapy NOUN O
by ADP O
0.35 NUM O
QALY PROPN B-AC
( PUNCT O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
years NOUN I-LF
) PUNCT O
. PUNCT O

ART PROPN B-AC
, PUNCT O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT O
cART PROPN B-AC
, PUNCT O
combination NOUN B-LF
antiretroviral ADJ I-LF
therapy NOUN I-LF
; PUNCT O
EE&T PROPN B-AC
, PUNCT O
Eastern PROPN B-LF
Europe PROPN I-LF
and CCONJ I-LF
Thailand PROPN I-LF
; PUNCT O
W&CE PROPN B-AC
, PUNCT O
Western PROPN B-LF
and CCONJ I-LF
Central PROPN I-LF
Europe PROPN I-LF
. PUNCT O

In ADP O
a DET O
recent ADJ O
local ADJ O
study NOUN O
among ADP O
mental ADJ O
health NOUN O
professionals NOUN O
working VERB O
at ADP O
the DET O
Institute PROPN B-LF
of ADP I-LF
Mental PROPN I-LF
Health PROPN I-LF
( PUNCT O
IMH PROPN B-AC
) PUNCT O
, PUNCT O
Yang PROPN O
et PROPN O
al NOUN O
[ X O
23 NUM O
] X O
similarly ADV O
found VERB O
staff NOUN O
were AUX O
experiencing VERB O
high ADJ O
levels NOUN O
of ADP O
stress NOUN O
and CCONJ O
burnout NOUN O
. PUNCT O

In ADP O
a DET O
previous ADJ O
study NOUN O
we PRON O
described VERB O
how SCONJ O
RSV PROPN B-AC
, PUNCT O
as ADP O
well ADV O
as ADP O
certain ADJ O
metabolites NOUN O
( PUNCT O
trans NOUN B-LF
- NOUN I-LF
resveratrol-3 NOUN I-LF
- NOUN I-LF
O NOUN I-LF
- NOUN I-LF
sulfate NOUN I-LF
-3S- NOUN B-AC
, PUNCT O
trans NOUN B-LF
- NOUN I-LF
resveratrol-3'-O NOUN I-LF
- NOUN O
glucuronide NOUN O
-3G- NOUN B-AC
and CCONJ O
trans NOUN B-LF
- NOUN I-LF
resveratrol-4'-O NOUN I-LF
- NOUN O
glucuronide NOUN O
-4G- NOUN B-AC
) PUNCT O
were AUX O
able ADJ O
to ADP O
modify VERB O
the DET O
expression NOUN O
of ADP O
genes NOUN O
related VERB O
to ADP O
the DET O
adipogenic ADJ O
process NOUN O
[ PUNCT O
25 NUM O
] PUNCT O
. PUNCT O

Therefore ADV O
, PUNCT O
we PRON O
serially ADV O
passaged VERB O
HPV18 PROPN O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
( PUNCT O
WT)- NOUN B-AC
and CCONJ O
ΔCTCF NOUN O
- PUNCT O
genome NOUN O
– PUNCT O
containing VERB O
human ADJ B-LF
foreskin NOUN I-LF
keratinocytes NOUN I-LF
( PUNCT O
HFKs PROPN B-AC
) PUNCT O
and CCONJ O
performed VERB O
Southern ADJ O
blot NOUN O
analysis NOUN O
to PART O
examine VERB O
HPV18 PROPN O
episome NOUN O
copy NOUN O
- PUNCT O
number NOUN O
variation NOUN O
over ADP O
time NOUN O
. PUNCT O

The DET O
radical ADJ O
scavenging NOUN O
ability NOUN O
of ADP O
oils NOUN O
investigated VERB O
by ADP O
2,2 NUM B-LF
- PUNCT I-LF
diphenyl-1 NOUN I-LF
- PUNCT I-LF
picrylhydrazyl NOUN I-LF
( PUNCT O
DPPH PROPN B-AC
) PUNCT O
assay NOUN O
revealed VERB O
that SCONJ O
the DET O
IC50 PROPN O
value NOUN O
of ADP O
GCO PROPN B-AC
was AUX O
significantly ADV O
lower ADJ O
than ADP O
of ADP O
RCO PROPN B-AC
( PUNCT O
p<0.05 NUM O
) PUNCT O
. PUNCT O

Decreases NOUN O
in ADP O
trabecular ADJ O
, PUNCT O
but CCONJ O
not PART O
cortical ADJ O
, PUNCT O
bone NOUN O
volumes NOUN O
over ADP O
total ADJ O
volumes NOUN O
( PUNCT O
BV NOUN B-AC
/ SYM B-AC
TV NOUN B-AC
) PUNCT O
, PUNCT O
trabecular ADJ B-LF
bone NOUN I-LF
number NOUN I-LF
( PUNCT O
Tb NOUN B-AC
. PUNCT B-AC
N NOUN B-AC
) PUNCT O
, PUNCT O
trabecular ADJ O
bone NOUN O
thickness NOUN O
, PUNCT O
and CCONJ O
increase NOUN O
in ADP O
trabecular ADJ B-LF
bone NOUN I-LF
space NOUN I-LF
( PUNCT O
Tb NOUN B-AC
. PUNCT B-AC
Sp PROPN B-AC
) PUNCT O
were AUX O
all PRON O
detected VERB O
in ADP O
LmnaHSA PROPN B-AC
- PUNCT B-AC
cko NOUN B-AC
mice NOUN O
as SCONJ O
compared VERB O
with ADP O
those PRON O
of ADP O
littermate NOUN O
controls NOUN O
( PUNCT O
Fig NOUN O
2 NUM O
G NOUN O
and CCONJ O
2H NOUN O
) PUNCT O
( PUNCT O
S3D NOUN O
and CCONJ O
S3E PROPN O
Fig NOUN O
) PUNCT O
. PUNCT O

There PRON O
were VERB O
4 NUM O
trials NOUN O
conducted VERB O
in ADP O
East PROPN O
Asia PROPN O
( PUNCT O
1 NUM O
Chinese ADJ O
and CCONJ O
3 NUM O
Japanese PROPN O
) PUNCT O
and CCONJ O
5 NUM O
trials NOUN O
outside ADP O
Asia PROPN O
: PUNCT O
Acarbose PROPN B-LF
Cardiovascular PROPN I-LF
Evaluation PROPN I-LF
( PUNCT O
ACE PROPN B-AC
) PUNCT O
[ PUNCT O
22 NUM O
] PUNCT O
, PUNCT O
Action PROPN B-LF
to PART I-LF
Control VERB I-LF
Cardiovascular PROPN I-LF
Risk PROPN I-LF
in ADP I-LF
Diabetes PROPN I-LF
( PUNCT O
ACCORD PROPN B-AC
) PUNCT O
[ PUNCT O
23 NUM O
] PUNCT O
, PUNCT O
Action PROPN B-LF
in ADP I-LF
Diabetes PROPN I-LF
and CCONJ I-LF
Vascular ADJ I-LF
disease NOUN I-LF
: PUNCT I-LF
preterAx NOUN I-LF
and CCONJ I-LF
diamicroN ADJ I-LF
- PROPN I-LF
MR NOUN I-LF
Controlled PROPN I-LF
Evaluation PROPN I-LF
( PUNCT O
ADVANCE PROPN B-AC
) PUNCT O
[ PUNCT O
24 NUM O
] PUNCT O
, PUNCT O
Diabetes PROPN B-LF
Prevention PROPN I-LF
Program PROPN I-LF
( PUNCT O
DPP PROPN B-AC
) PUNCT O
[ PUNCT O
25 NUM O
] PUNCT O
, PUNCT O
Japan PROPN B-LF
Diabetes PROPN I-LF
Complications PROPN I-LF
Study PROPN I-LF
( PUNCT O
JDCS PROPN B-AC
) PUNCT O
[ PUNCT O
26 NUM O
] PUNCT O
, PUNCT O
Japan PROPN B-LF
Elderly PROPN I-LF
Diabetes PROPN I-LF
Intervention PROPN I-LF
Trial PROPN I-LF
( PUNCT O
J PROPN B-AC
- PROPN B-AC
EDIT PROPN B-AC
) PUNCT O
[ PUNCT O
27 NUM O
] PUNCT O
, PUNCT O
Japanese PROPN B-LF
Primary PROPN I-LF
Prevention PROPN I-LF
of ADP I-LF
Atherosclerosis PROPN I-LF
with ADP I-LF
Aspirin PROPN I-LF
for ADP I-LF
Diabetes PROPN I-LF
trial NOUN O
( PUNCT O
JPAD PROPN B-AC
) PUNCT O
[ PUNCT O
28 NUM O
] PUNCT O
, PUNCT O
and CCONJ O
UK PROPN B-LF
Prospective PROPN I-LF
Diabetes PROPN I-LF
Study PROPN I-LF
33 NUM I-LF
and CCONJ I-LF
80 NUM I-LF
( PUNCT O
UKPDS PROPN B-AC
33 NUM B-AC
and CCONJ B-AC
80 NUM B-AC
) PUNCT O
[ PUNCT O
29,30 NUM O
] PUNCT O
. PUNCT O

8 NUM O
- PUNCT O
OHdG NOUN O
, PUNCT O
8 NUM O
- PUNCT O
hydroxy-2′-deoxyguanosine NOUN O
; PUNCT O
BPA PROPN B-AC
, PUNCT O
bisphenol NOUN B-LF
A NOUN I-LF
; PUNCT O
DEHP PROPN B-AC
, PUNCT O
di(2 NOUN B-LF
- PUNCT I-LF
ethylhexyl NOUN I-LF
) PUNCT I-LF
phthalate NOUN I-LF
; PUNCT O
DOP PROPN B-AC
, PUNCT O
di NOUN B-LF
- PUNCT I-LF
n NOUN I-LF
- PUNCT I-LF
octyl NOUN I-LF
phthalate NOUN I-LF
; PUNCT O
HMW PROPN B-AC
, PUNCT O
high ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
; PUNCT O
LMW PROPN B-AC
, PUNCT O
low ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
; PUNCT O
PA PROPN B-AC
, PUNCT O
phthalic NOUN B-LF
acid NOUN I-LF
. PUNCT O

Bcat2 NOUN O
, PUNCT O
β NOUN O
- NOUN O
catenin-2 NOUN O
; PUNCT O
RNAi NOUN B-AC
, PUNCT O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT O

We PRON O
conducted VERB O
a DET O
two NUM O
- PUNCT O
sample NOUN O
Mendelian ADJ B-LF
randomization NOUN I-LF
( PUNCT O
MR PROPN B-AC
) PUNCT O
analysis NOUN O
to PART O
evaluate VERB O
the DET O
relationship NOUN O
between ADP O
coffee NOUN O
consumption NOUN O
and CCONJ O
breast NOUN O
cancer NOUN O
risk NOUN O
using VERB O
33 NUM O
single ADJ B-LF
- PUNCT I-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT O
SNPs PROPN B-AC
) PUNCT O
associated VERB O
with ADP O
coffee NOUN O
consumption NOUN O
from ADP O
a DET O
genome NOUN B-LF
- PUNCT I-LF
wide ADJ I-LF
association NOUN I-LF
( PUNCT O
GWA PROPN B-AC
) PUNCT O
study NOUN O
on ADP O
212,119 NUM O
female ADJ O
UK PROPN O
Biobank PROPN O
participants NOUN O
of ADP O
White ADJ O
British ADJ O
ancestry NOUN O
. PUNCT O

IPW PROPN B-AC
= PUNCT O
Inverse ADJ B-LF
Probability NOUN I-LF
Weighting NOUN I-LF

An DET O
adaptive ADJ O
multi ADJ O
- PUNCT O
arm ADJ O
, PUNCT O
2 NUM O
- PUNCT O
stage NOUN O
cluster NOUN O
randomised VERB O
trial NOUN O
was AUX O
conducted VERB O
between ADP O
8 NUM O
August PROPN O
2016 NUM O
and CCONJ O
30 NUM O
June PROPN O
2017 NUM O
, PUNCT O
with ADP O
antenatal ADJ B-LF
care NOUN I-LF
clinic NOUN I-LF
( PUNCT O
ANC PROPN B-AC
) PUNCT O
days NOUN O
( PUNCT O
i.e. X O
, PUNCT O
clusters NOUN O
of ADP O
women NOUN O
attending VERB O
on ADP O
a DET O
single ADJ O
day NOUN O
) PUNCT O
as ADP O
the DET O
unit NOUN O
of ADP O
randomisation NOUN O
. PUNCT O

Peptide NOUN O
composition NOUN O
was AUX O
refined VERB O
using VERB O
database NOUN B-LF
2 NUM O
( PUNCT O
db-2 NOUN B-AC
) PUNCT O
( PUNCT O
unpublished ADJ O
data NOUN O
) PUNCT O
. PUNCT O

To PART O
measure VERB O
work NOUN O
intensity NOUN O
or CCONJ O
aerobic ADJ O
strain NOUN O
, PUNCT O
the DET O
recording NOUN O
of ADP O
heart NOUN B-LF
rate NOUN I-LF
( PUNCT O
HR NOUN B-AC
) PUNCT O
is AUX O
a DET O
valid ADJ O
method NOUN O
. PUNCT O

Upon SCONJ O
ABA PROPN B-AC
perception NOUN O
, PUNCT O
the DET O
soluble ADJ O
ABA PROPN B-AC
receptors NOUN O
interact VERB O
with ADP O
and CCONJ O
inhibit VERB O
clade NOUN O
- PUNCT O
A NOUN O
protein NOUN B-LF
phosphatase NOUN I-LF
2Cs NOUN I-LF
( PUNCT O
PP2Cs NOUN B-AC
): PUNCT O
ABA PROPN B-LF
- PUNCT I-LF
insensitive ADJ I-LF
1 NUM I-LF
( PUNCT O
ABI1 PROPN B-AC
) PUNCT O
, PUNCT O
ABA PROPN B-LF
- PUNCT I-LF
insensitive ADJ I-LF
2 NUM I-LF
( PUNCT O
ABI2 PROPN B-AC
) PUNCT O
, PUNCT O
hypersensitive ADJ B-LF
to ADP I-LF
ABA PROPN I-LF
1 NUM I-LF
( PUNCT O
HAB1 PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
protein NOUN B-LF
phosphatase NOUN I-LF
2CA NUM I-LF
( PUNCT O
PP2CA PROPN B-AC
) PUNCT O
; PUNCT O
this DET O
interaction NOUN O
relieves VERB O
inhibition NOUN O
of ADP O
the DET O
serine NOUN O
- PUNCT O
threonine NOUN O
kinase NOUN O
OPEN PROPN B-LF
STOMATA PROPN I-LF
1 NUM I-LF
( PUNCT O
OST1 PROPN B-AC
) PUNCT O
[ PUNCT O
24 NUM O
] PUNCT O
. PUNCT O

CI NOUN B-AC
= PUNCT O
confidence NOUN B-LF
interval NOUN I-LF
, PUNCT O
Q1 NOUN B-AC
- PUNCT B-AC
Q3 NOUN B-AC
= PUNCT O
Quartile NOUN B-LF
1 NUM I-LF
– PUNCT I-LF
Quartile NOUN I-LF
3 NUM I-LF

We PRON O
explore VERB O
whether SCONJ O
the DET O
‘ PUNCT O
Auditory PROPN B-LF
Stroop PROPN I-LF
Task PROPN I-LF
’ PUNCT O
( PUNCT O
AST PROPN B-AC
) PUNCT O
can AUX O
be AUX O
used VERB O
to PART O
increase VERB O
cognitive ADJ O
load NOUN O
( PUNCT O
and CCONJ O
thereby ADV O
elicit VERB O
FOG NOUN B-AC
) PUNCT O
, PUNCT O
simultaneously ADV O
with ADP O
visual ADJ O
cues NOUN O
( PUNCT O
as ADP O
a DET O
therapeutic ADJ O
intervention NOUN O
for ADP O
FOG NOUN B-AC
) PUNCT O
. PUNCT O
We PRON O
additionally ADV O
examined VERB O
how SCONJ O
these DET O
two NUM O
contrasting VERB O
effects NOUN O
might AUX O
interact VERB O
in ADP O
affecting VERB O
gait NOUN O
and CCONJ O
FOG NOUN B-AC
parameters NOUN O
. PUNCT O

factor NOUN B-LF
Xa PROPN I-LF

This DET O
G1 PROPN O
transcriptional ADJ O
circuit NOUN O
is AUX O
analogous ADJ O
to ADP O
that PRON O
defined VERB O
in ADP O
mammals NOUN O
by ADP O
the DET O
E2F PROPN O
family NOUN O
of ADP O
transcription NOUN O
factors NOUN O
and CCONJ O
the DET O
retinoblastoma NOUN B-LF
( PUNCT O
Rb PROPN B-AC
) PUNCT O
tumor NOUN O
suppressor NOUN O
protein NOUN O
. PUNCT O

H3K4me3 NOUN B-AC
, PUNCT O
H3 NOUN B-LF
trimethylation NOUN I-LF
of ADP I-LF
lysine NOUN I-LF
residue NOUN I-LF
4 NUM I-LF
. PUNCT O

Overexpression NOUN O
of ADP O
cdk5 PROPN B-AC
( PUNCT O
either CCONJ O
alone ADV O
or CCONJ O
with ADP O
its PRON O
coactivator NOUN O
, PUNCT O
p35 NOUN O
; PUNCT O
[ X O
23 NUM O
] PUNCT O
) PUNCT O
or CCONJ O
inhibition NOUN O
with ADP O
DNcdk5 PROPN O
had VERB O
no DET O
significant ADJ O
effects NOUN O
( PUNCT O
p NOUN O
> SYM O
0.2 NUM O
) PUNCT O
on ADP O
the DET O
proliferation NOUN O
of ADP O
adult ADJ O
rat NOUN O
NPCs NOUN B-AC
( PUNCT O
Figure PROPN O
1A–1E NUM O
) PUNCT O
or CCONJ O
mouse NOUN O
NPCs NOUN B-AC
( PUNCT O
unpublished ADJ O
data NOUN O
) PUNCT O
, PUNCT O
as SCONJ O
measured VERB O
by ADP O
the DET O
number NOUN O
of ADP O
bromo NOUN B-LF
- PUNCT I-LF
deoxy NOUN I-LF
- PUNCT I-LF
uridine NOUN I-LF
( PUNCT O
BrdU)-incorporating VERB B-AC
cells NOUN O
after ADP O
a DET O
1 NUM O
- PUNCT O
h NOUN O
pulse NOUN O
. PUNCT O

Disturbances NOUN O
in ADP O
ER PROPN B-AC
homeostasis NOUN O
initiate VERB O
the DET O
unfolded ADJ B-LF
protein NOUN I-LF
response NOUN I-LF
( PUNCT O
UPR NOUN B-AC
) PUNCT O
implicated VERB O
in ADP O
the DET O
pathogenesis NOUN O
of ADP O
many ADJ O
human ADJ O
diseases NOUN O
. PUNCT O

The DET O
recommended ADJ O
dosage NOUN O
regimen NOUN O
of ADP O
laronidase NOUN O
is AUX O
0.58 NUM O
mg NOUN O
/ SYM O
kg NOUN O
body NOUN O
weight NOUN O
, PUNCT O
administered VERB O
once ADV O
weekly ADV O
as ADP O
an DET O
intravenous ADJ B-LF
( PUNCT O
IV PROPN B-AC
) PUNCT O
infusion NOUN O
. PUNCT O

Conducted VERB O
by ADP O
the DET O
Centers PROPN B-LF
for ADP I-LF
Disease PROPN I-LF
Control PROPN I-LF
and CCONJ I-LF
Prevention PROPN I-LF
’s PART O
( PUNCT O
CDC PROPN B-AC
) PUNCT O
National PROPN O
Center PROPN O
for ADP O
Health PROPN O
Statistics PROPN O
( PUNCT O
NCHS PROPN O
) PUNCT O
, PUNCT O
the DET O
National PROPN B-LF
Health PROPN I-LF
and CCONJ I-LF
Nutrition PROPN I-LF
Examination PROPN I-LF
Survey PROPN I-LF
( PUNCT O
NHANES PROPN B-AC
) PUNCT O
collects VERB O
nationally ADV O
representative ADJ O
environmental ADJ O
biomonitoring NOUN O
data NOUN O
from ADP O
about ADV O
5,000 NUM O
annual ADJ O
participants NOUN O
in ADP O
each DET O
two NUM O
- PUNCT O
year NOUN O
cycle NOUN O
[ PUNCT O
2,45–48 NUM O
] PUNCT O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
AC PROPN B-AC
, PUNCT O
Adherence PROPN B-LF
Club PROPN I-LF
; PUNCT O
DiD PROPN B-AC
, PUNCT O
difference NOUN B-LF
in ADP I-LF
differences NOUN I-LF
; PUNCT O
GEE PROPN B-AC
, PUNCT O
generalized ADJ B-LF
estimating NOUN I-LF
equation NOUN I-LF
; PUNCT O
GP PROPN O
, PUNCT O
Gauteng PROPN O
Province PROPN O
; PUNCT O
KZN PROPN O
, PUNCT O
KwaZulu PROPN O
Natal PROPN O
; PUNCT O
LP PROPN O
, PUNCT O
Limpopo PROPN O
Province PROPN O
; PUNCT O
NW PROPN O
, PUNCT O
North PROPN O
West PROPN O
; PUNCT O
RD NOUN O
, PUNCT O
risk NOUN O
difference NOUN O
; PUNCT O
VL PROPN O
, PUNCT O
viral ADJ O
load NOUN O
. PUNCT O

We PRON O
obtained VERB O
FTD PROPN B-AC
GWAS PROPN B-AC
summary NOUN O
statistic NOUN O
data NOUN O
from ADP O
phase NOUN O
I NUM O
of ADP O
the DET O
International PROPN B-LF
FTD PROPN I-LF
- PUNCT I-LF
Genomics PROPN I-LF
Consortium PROPN I-LF
( PUNCT O
IFGC PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
consisted VERB O
of ADP O
2,154 NUM O
clinical ADJ O
FTD PROPN B-AC
cases NOUN O
and CCONJ O
4,308 NUM O
controls NOUN O
with ADP O
genotyped VERB O
and CCONJ O
imputed VERB O
data NOUN O
at ADP O
6,026,384 NUM O
SNPs NOUN B-AC
( PUNCT O
Table NOUN O
1 NUM O
; PUNCT O
for ADP O
additional ADJ O
details NOUN O
, PUNCT O
see VERB O
[ PRON O
5 NUM O
] PUNCT O
) PUNCT O
. PUNCT O

At ADP O
12 NUM O
months NOUN O
of ADP O
age NOUN O
, PUNCT O
soluble ADJ O
and CCONJ O
insoluble ADJ O
Aβ40 PROPN O
and CCONJ O
Aβ42 PROPN O
were AUX O
increased VERB O
by ADP O
62 NUM O
% NOUN O
, PUNCT O
52 NUM O
% NOUN O
, PUNCT O
62 NUM O
% NOUN O
, PUNCT O
and CCONJ O
36 NUM O
% NOUN O
in ADP O
brains NOUN O
of ADP O
APPPS1 PROPN O
– SYM O
Adamts13−/− SYM O
mice NOUN O
, PUNCT O
respectively ADV O
, PUNCT O
compared VERB O
with ADP O
those PRON O
in ADP O
APPPS1 PROPN O
littermates NOUN O
( PUNCT O
Fig NOUN O
4A NUM O
and CCONJ O
4B NUM O
) PUNCT O
. PUNCT O
Aβ NOUN B-AC
immunostaining NOUN O
and CCONJ O
thioflavin NOUN B-LF
S PROPN I-LF
( PUNCT O
ThS PROPN B-AC
) PUNCT O
staining NOUN O
confirmed VERB O
this DET O
observation NOUN O
, PUNCT O
showing VERB O
that SCONJ O
the DET O
cortical ADJ O
and CCONJ O
hippocampal ADJ O
plaque NOUN O
load NOUN O
were AUX O
markedly ADV O
elevated ADJ O
in ADP O
APPPS1 PROPN O
– SYM O
Adamts13−/− SYM O
mice NOUN O
compared VERB O
with ADP O
APPPS1 PROPN O
mice NOUN O
( PUNCT O
Fig NOUN O
4C NUM O
, PUNCT O
4D NUM O
and CCONJ O
4E NUM O
) PUNCT O
. PUNCT O
Furthermore ADV O
, PUNCT O
APPPS1 PROPN O
– SYM O
Adamts13−/− SYM O
mice NOUN O
developed VERB O
2.3 NUM O
- PUNCT O
fold ADJ O
and CCONJ O
1.7 NUM O
- PUNCT O
fold ADJ O
increases NOUN O
in ADP O
cerebral ADJ B-LF
amyloid NOUN I-LF
angiopathy NOUN I-LF
( PUNCT O
CAA PROPN B-AC
) PUNCT O
and CCONJ O
parenchymal ADJ O
amyloid NOUN O
deposition NOUN O
, PUNCT O
respectively ADV O
, PUNCT O
as SCONJ O
measured VERB O
by ADP O
in ADP O
vivo ADJ O
multiphoton NOUN O
imaging NOUN O
of ADP O
methoxy NOUN O
- PUNCT O
X04 NOUN O
+ NOUN O
amyloid NOUN O
plaques NOUN O
and CCONJ O
Tetramethylrhodamine NOUN B-LF
( PUNCT O
TMR)-dextran NOUN B-AC
angiopathy NOUN O
( PUNCT O
Fig NOUN O
4F NUM O
and CCONJ O
4 NUM O
G NOUN O
) PUNCT O
. PUNCT O
Notably ADV O
, PUNCT O
the DET O
CAA PROPN B-AC
load NOUN O
was AUX O
positively ADV O
correlated VERB O
with ADP O
the DET O
BBB PROPN B-AC
permeability NOUN O
determined VERB O
by ADP O
the DET O
permeability NOUN B-LF
surface NOUN I-LF
( PUNCT O
PS PROPN B-AC
) PUNCT O
product NOUN O
for ADP O
FITC PROPN B-AC
- PUNCT O
dextran NOUN O
in ADP O
APPPS1 PROPN O
and CCONJ O
APPPS1 PROPN O
– SYM O
Adamts13−/− SYM O
mice NOUN O
( PUNCT O
Fig NOUN O
4H NUM O
) PUNCT O
. PUNCT O

Plus NOUN O
– PUNCT O
minus NOUN O
values NOUN O
are AUX O
means NOUN O
± ADP O
standard ADJ B-LF
error NOUN I-LF
( PUNCT O
SE NOUN B-AC
) PUNCT O
. PUNCT O
Analysis NOUN O
of ADP O
covariance NOUN O
was AUX O
used VERB O
to PART O
assess VERB O
differences NOUN O
between ADP O
groups NOUN O
at ADP O
follow NOUN O
- PUNCT O
up NOUN O
, PUNCT O
adjusted VERB O
for ADP O
baseline NOUN O
. PUNCT O

The DET O
individual ADJ O
values NOUN O
represent VERB O
the DET O
percentage NOUN O
of ADP O
total ADJ O
number NOUN O
of ADP O
dogs NOUN O
in ADP O
each DET O
breed NOUN O
with ADP O
Merle PROPN O
mosaicism NOUN O
detected VERB O
[ X O
ASD PROPN B-AC
– PUNCT O
Australian PROPN B-LF
Shepherd PROPN I-LF
Dog PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
40 NUM O
) PUNCT O
, PUNCT O
AK PROPN B-AC
– PUNCT O
Australian PROPN B-LF
Koolie PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
23 NUM O
) PUNCT O
, PUNCT O
BC PROPN B-AC
– PUNCT O
Border PROPN B-LF
Collie PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
18 NUM O
) PUNCT O
, PUNCT O
D PROPN O
– PUNCT O
Dachshund PROPN O
( PUNCT O
n NOUN O
= SYM O
9 NUM O
) PUNCT O
, PUNCT O
LC PROPN B-AC
– PUNCT O
Louisiana PROPN B-LF
Catahoula PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
73 NUM O
) PUNCT O
, PUNCT O
MAUS PROPN B-AC
– PUNCT O
Miniature PROPN B-LF
Australian PROPN I-LF
Shepherd PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
2 NUM O
) PUNCT O
, PUNCT O
SSD PROPN B-AC
– PUNCT O
Shetland PROPN B-LF
Sheepdog PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
2 NUM O
) PUNCT O
, PUNCT O
FB PROPN B-AC
– PUNCT O
French PROPN B-LF
Bulldog PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
2 NUM O
) PUNCT O
, PUNCT O
WS PROPN B-AC
– PUNCT O
Welsh PROPN B-LF
Sheepdog PROPN I-LF
( PUNCT O
n NOUN O
= SYM O
3 NUM O
) PUNCT O
, PUNCT O
M PROPN O
– PUNCT O
Mudi PROPN O
( PUNCT O
n NOUN O
= SYM O
2 NUM O
) PUNCT O
] PUNCT O
of ADP O
all DET O
tested VERB O
dogs NOUN O
( PUNCT O
n NOUN O
= SYM O
181 NUM O
) PUNCT O
. PUNCT O

Animals NOUN O
were AUX O
anaesthetized VERB O
by ADP O
2%-Isoflurane NOUN O
inhalation NOUN O
, PUNCT O
intubated VERB O
and CCONJ O
ventilated VERB O
with ADP O
100 NUM O
% NOUN O
oxygen NOUN O
( PUNCT O
0.7 NUM O
ml/100 NUM O
g NOUN O
bodyweight NOUN B-LF
[ PUNCT O
BW NOUN B-AC
] PUNCT O
, PUNCT O
90 NUM O
/ SYM O
min NOUN O
) PUNCT O
and CCONJ O
cardiac ADJ O
hypertrophy NOUN O
was AUX O
induced VERB O
as SCONJ O
described VERB O
from ADP O
Zaha PROPN O
and CCONJ O
colleagues NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

Cao PROPN O
and CCONJ O
Sudhof PROPN O
[ X O
56 NUM O
] X O
have AUX O
recently ADV O
discovered VERB O
that PRON O
the DET O
APP PROPN B-AC
C PROPN O
- NOUN O
terminal ADJ O
fragment NOUN O
generated VERB O
by ADP O
α- NOUN O
or CCONJ O
β NOUN O
- NOUN O
secretase NOUN O
is AUX O
itself PRON O
cleaved VERB O
to PART O
release VERB O
Aβ PROPN B-AC
and CCONJ O
an DET O
APP PROPN B-LF
intracellular ADJ I-LF
domain NOUN I-LF
( PUNCT O
AICD PROPN B-AC
) PUNCT O
that PRON O
diffuses VERB O
into ADP O
the DET O
nucleus NOUN O
, PUNCT O
possibly ADV O
acting VERB O
there ADV O
as ADP O
a DET O
transcription NOUN O
factor NOUN O
. PUNCT O

ALD PROPN B-AC
, PUNCT O
alcoholic ADJ B-LF
liver NOUN I-LF
disease NOUN I-LF
; PUNCT O
HCV PROPN B-AC
, PUNCT O
hepatitis NOUN B-LF
C PROPN I-LF
virus NOUN I-LF
; PUNCT O
NAFLD PROPN B-AC
, PUNCT O
non ADJ O
- ADJ O
alcoholic ADJ O
fatty ADJ O
liver NOUN O
disease NOUN O
. PUNCT O

LDSm NOUN B-AC
= PUNCT O
Latent PROPN B-LF
Difference PROPN I-LF
Score PROPN I-LF
model NOUN I-LF
, PUNCT O
Latent PROPN O
GSE PROPN B-AC
= PUNCT O
General PROPN B-LF
Self PROPN I-LF
- PUNCT I-LF
Efficacy PROPN I-LF
, PUNCT O
TCS PROPN B-AC
= PUNCT O
Transition PROPN B-LF
Competence PROPN I-LF
Scale PROPN I-LF
, PUNCT O
PAM PROPN B-AC
= PUNCT O
Patient PROPN O
Activation PROPN O
Measurement PROPN O
– PUNCT O
German PROPN O
Youth PROPN O
Version PROPN O
. PUNCT O

Medium ADJ B-LF
- PUNCT I-LF
chain NOUN I-LF
acyl NOUN I-LF
- PUNCT I-LF
CoA NOUN I-LF
dehydrogenase NOUN I-LF
( PUNCT O
MCAD PROPN B-AC
) PUNCT O
deficiency NOUN O
is AUX O
one NUM O
of ADP O
the DET O
most ADV O
common ADJ O
inherited VERB O
disorders NOUN O
of ADP O
metabolism NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
DAS28 PROPN B-AC
, PUNCT O
Disease PROPN B-LF
Activity PROPN I-LF
Score-28 PROPN I-LF
; PUNCT O
TNFi PROPN B-AC
, PUNCT O
tumour NOUN O
necrosis NOUN O
factor NOUN O
inhibitor NOUN O

Within ADP O
a DET O
Developmental PROPN B-LF
Origins PROPN I-LF
of ADP I-LF
Health PROPN I-LF
and CCONJ I-LF
Disease PROPN I-LF
( PUNCT O
DOHaD PROPN B-AC
) PUNCT O
framework NOUN O
, PUNCT O
the DET O
first ADJ O
1,000 NUM O
days NOUN O
of ADP O
life NOUN O
, PUNCT O
i.e. X O
, PUNCT O
the DET O
period NOUN O
from ADP O
conception NOUN O
to ADP O
age NOUN O
2 NUM O
years NOUN O
, PUNCT O
is AUX O
regarded VERB O
as ADP O
a DET O
critical ADJ O
period NOUN O
for ADP O
long ADJ O
- PUNCT O
term NOUN O
cardiovascular ADJ O
health NOUN O
[ PUNCT O
1 NUM O
] PUNCT O
. PUNCT O

As ADP O
a DET O
first ADJ O
step NOUN O
toward ADP O
this DET O
goal NOUN O
, PUNCT O
we PRON O
asked VERB O
whether SCONJ O
conditions NOUN O
could AUX O
be AUX O
found VERB O
that PRON O
allow VERB O
cultured VERB O
cells NOUN O
to ADP O
proliferate VERB O
despite SCONJ O
an DET O
activated VERB O
UPR NOUN B-AC
. PUNCT O
We PRON O
chose VERB O
as ADP O
our PRON O
experimental ADJ O
cell NOUN O
type NOUN O
mouse NOUN B-LF
embryonic ADJ I-LF
fibroblasts NOUN I-LF
( PUNCT O
MEFs PROPN B-AC
) PUNCT O
, PUNCT O
because SCONJ O
, PUNCT O
as ADP O
primary ADJ O
non ADJ O
- ADJ O
immortalized ADJ O
cells NOUN O
, PUNCT O
they PRON O
are AUX O
less ADV O
likely ADJ O
than ADP O
immortalized ADJ O
cell NOUN O
lines NOUN O
to ADP O
be AUX O
intrinsically ADV O
resistant ADJ O
to ADP O
stress NOUN O
. PUNCT O

CDS PROPN B-AC
, PUNCT O
coding VERB B-LF
DNA NOUN I-LF
sequence NOUN I-LF
; PUNCT O
RPF PROPN B-AC
, PUNCT O
ribosome NOUN B-LF
- PUNCT I-LF
protected VERB I-LF
mRNA NOUN I-LF
fragment NOUN I-LF
; PUNCT O
SE PROPN B-AC
, PUNCT O
standard ADJ B-LF
error NOUN I-LF
; PUNCT O
TE NOUN B-AC
, PUNCT O
translational ADJ B-LF
efficiency NOUN I-LF
; PUNCT O
uORF NOUN B-AC
, PUNCT O
upstream ADJ B-LF
open ADJ I-LF
reading NOUN I-LF
frame NOUN I-LF
. PUNCT O

We PRON O
did AUX O
not PART O
find VERB O
support NOUN O
for ADP O
this DET O
hypothesis NOUN O
in ADP O
our PRON O
data NOUN O
, PUNCT O
as ADP O
there PRON O
was VERB O
no DET O
association NOUN O
between ADP O
antagonism NOUN O
and CCONJ O
higher ADJ O
levels NOUN O
of ADP O
pleiotropy NOUN O
, PUNCT O
measured VERB O
either CCONJ O
as ADP O
tissue NOUN O
breadth NOUN O
τ NOUN O
[ X O
43 NUM O
] X O
( PUNCT O
W NOUN O
= SYM O
1,264,700 NUM O
, PUNCT O
P NOUN O
= SYM O
0.70 NUM O
) PUNCT O
or CCONJ O
as ADP O
the DET O
number NOUN O
of ADP O
protein NOUN B-LF
– PUNCT I-LF
protein NOUN I-LF
interactions NOUN I-LF
( PUNCT O
PPIs PROPN B-AC
) PUNCT O
[ X O
44 NUM O
] X O
( PUNCT O
F1,5276 NUM O
= SYM O
2.43 NUM O
, PUNCT O
P NOUN O
= SYM O
0.12 NUM O
) PUNCT O
. PUNCT O

IUGR PROPN B-AC
, PUNCT O
intrauterine ADJ B-LF
growth NOUN I-LF
restricted VERB I-LF
; PUNCT O
UNI PROPN B-AC
- PUNCT B-AC
X PROPN B-AC
, PUNCT O
uninephrectomized VERB B-LF
. PUNCT O

ACC PROPN B-AC
, PUNCT O
acetyl NOUN B-LF
- PUNCT I-LF
coA NOUN I-LF
carboxylase NOUN I-LF
; PUNCT O
ChREBP PROPN B-AC
, PUNCT O
carbohydrate NOUN B-LF
- PUNCT I-LF
responsive ADJ I-LF
element NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT O
CON PROPN O
, PUNCT O
control NOUN O
; PUNCT O
E2 PROPN B-AC
, PUNCT O
estradiol NOUN B-LF
; PUNCT O
EHHADH PROPN B-AC
, PUNCT O
enoyl NOUN O
- PUNCT O
coA NOUN O
hydratase NOUN O
and CCONJ O
3 NUM O
- PUNCT O
hydroxyacyl NOUN O
coA NOUN O
; PUNCT O
Fas PROPN B-AC
, PUNCT O
fatty ADJ B-LF
acid NOUN I-LF
synthase NOUN I-LF
; PUNCT O
GAPDH PROPN B-AC
, PUNCT O
glyceraldehyde-3 NOUN B-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
; PUNCT O
HFD PROPN B-AC
, PUNCT O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
; PUNCT O
IPITT PROPN B-AC
, PUNCT O
intraperitoneal ADJ B-LF
insulin NOUN I-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT O
ME1 PROPN B-AC
, PUNCT O
cytosolic ADJ B-LF
malic ADJ I-LF
enzyme NOUN I-LF
1 NUM I-LF
; PUNCT O
OVX PROPN B-AC
, PUNCT O
ovariectomy NOUN B-LF
; PUNCT O
p NOUN B-AC
- PUNCT B-AC
ACC PROPN B-AC
, PUNCT O
phosphorylated VERB B-LF
acetyl NOUN I-LF
- PUNCT I-LF
coA NOUN I-LF
carboxylase NOUN I-LF
; PUNCT O
SCD-1 PROPN B-AC
, PUNCT O
stearoyl NOUN B-LF
- PUNCT I-LF
coA NOUN I-LF
desaturase-1 NOUN I-LF
; PUNCT O
SREBP-1c PROPN B-AC
, PUNCT O
sterol NOUN B-LF
regulatory ADJ I-LF
element NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
1 NUM I-LF
- PUNCT I-LF
c NOUN I-LF
; PUNCT O
TG PROPN B-AC
, PUNCT O
triglyceride NOUN B-LF
; PUNCT O
WT PROPN B-AC
, PUNCT O
wild ADJ O
- PUNCT O
type NOUN O
. PUNCT O

This DET O
study NOUN O
used VERB O
the DET O
monthly ADJ O
income NOUN O
calculated VERB O
from ADP O
the DET O
NHI PROPN O
premium NOUN O
as ADP O
a DET O
proxy NOUN O
for ADP O
individual ADJ O
socioeconomic ADJ B-LF
status NOUN I-LF
( PUNCT O
SES PROPN B-AC
) PUNCT O
. PUNCT O
Individuals NOUN O
were AUX O
classified VERB O
into ADP O
three NUM O
income NOUN O
groups NOUN O
: PUNCT O
( PUNCT O
1 X O
) PUNCT O
low ADJ O
( PUNCT O
< PUNCT O
NT$15,840 NUM O
per ADP O
month NOUN O
) PUNCT O
; PUNCT O
( PUNCT O
2 X O
) PUNCT O
medium ADJ O
( PUNCT O
NT$15,840 NUM O
– SYM O
NT$25,000 NUM O
per ADP O
month NOUN O
) PUNCT O
; PUNCT O
and CCONJ O
( PUNCT O
3 X O
) PUNCT O
high ADJ O
( PUNCT O
> PUNCT O
NT$25,000 NUM O
per ADP O
month NOUN O
) PUNCT O
. PUNCT O

Initial ADJ O
thematic ADJ O
analysis NOUN O
[ X O
37 NUM O
] X O
and CCONJ O
subsequent ADJ O
analysis NOUN O
sensitised VERB O
by ADP O
the DET O
Theoretical PROPN B-LF
Framework PROPN I-LF
of ADP I-LF
Acceptability PROPN I-LF
( PUNCT O
TFA PROPN B-AC
) PUNCT O
[ X O
38 NUM O
] X O
were AUX O
undertaken VERB O
. PUNCT O

Two NUM O
homologous ADJ O
GTPases NOUN O
, PUNCT O
one NUM O
in ADP O
the DET O
signal NOUN B-LF
recognition NOUN I-LF
particle NOUN I-LF
( PUNCT O
SRP PROPN B-AC
) PUNCT O
and CCONJ O
one NUM O
in ADP O
the DET O
SRP PROPN B-LF
receptor NOUN I-LF
( PUNCT O
SR PROPN B-AC
; PUNCT O
called VERB O
Ffh PROPN O
and CCONJ O
FtsY PROPN O
in ADP O
bacteria NOUN O
, PUNCT O
respectively ADV O
) PUNCT O
, PUNCT O
mediate VERB O
the DET O
cotranslational ADJ O
targeting NOUN O
of ADP O
membrane NOUN O
and CCONJ O
secretory NOUN O
proteins NOUN O
to ADP O
the DET O
eukaryotic ADJ O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT O
ER PROPN B-AC
) PUNCT O
membrane NOUN O
or CCONJ O
the DET O
bacterial ADJ O
plasma NOUN O
membrane NOUN O
. PUNCT O

- PUNCT O
No DET O
need NOUN O
for ADP O
" PUNCT O
Basic PROPN B-LF
Metabolic PROPN I-LF
Panel PROPN I-LF
[ PUNCT O
BMP PROPN B-AC
] PUNCT O
: PUNCT O
" PUNCT O
, PUNCT O
" PUNCT O
Liver PROPN B-LF
Function PROPN I-LF
Test PROPN I-LF
[ PUNCT O
LFT PROPN B-AC
] PUNCT O
: PUNCT O
" PUNCT O
as SCONJ O
the DET O
details NOUN O
are AUX O
followed VERB O
. PUNCT O

Uric NOUN O
acid NOUN O
has AUX O
been AUX O
shown VERB O
to ADP O
associate VERB O
with ADP O
vascular ADJ O
calcification NOUN O
and CCONJ O
with ADP O
carotid ADJ B-LF
intima NOUN I-LF
- PUNCT I-LF
media NOUN I-LF
thickness NOUN I-LF
( PUNCT O
CIMT PROPN B-AC
) PUNCT O
and CCONJ O
to ADP O
suppress VERB O
the DET O
1 NUM O
α NOUN O
- PUNCT O
hydroxylase NOUN O
enzyme NOUN O
leading VERB O
to ADP O
lower ADJ O
1,25 NUM B-LF
- PUNCT I-LF
dihydroxyvitamin NOUN I-LF
D PROPN I-LF
( PUNCT O
1,25(OH)2D NUM B-AC
) PUNCT O
and CCONJ O
higher ADJ O
intact ADJ B-LF
parathyroid ADJ I-LF
hormone NOUN I-LF
( PUNCT O
iPTH PROPN B-AC
) PUNCT O
levels NOUN O
. PUNCT O

Analysis NOUN O
of ADP O
pairwise ADJ O
distances NOUN O
showed VERB O
that SCONJ O
matK+rbcL+trnL NOUN B-LF
- PUNCT I-LF
F+trnH NOUN I-LF
- PUNCT I-LF
psbA+ITS NOUN I-LF
( PUNCT O
MRTPI NOUN B-AC
) PUNCT O
had VERB O
the DET O
greatest ADJ O
value NOUN O
and CCONJ O
rbcL NOUN O
the DET O
least ADJ O
. PUNCT O

Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT O
BMI NOUN B-AC
) PUNCT O
was AUX O
calculated VERB O
as ADP O
body NOUN O
weight NOUN O
( PUNCT O
kg)/height NOUN O
( PUNCT O
m2 NOUN O
) PUNCT O
. PUNCT O

Cytokines NOUN O
and CCONJ O
interferons NOUN O
( PUNCT O
all PRON O
called VERB O
cytokines NOUN O
from ADP O
here ADV O
on ADV O
) PUNCT O
were AUX O
determined VERB O
in ADP O
cell NOUN O
culture NOUN O
supernatants NOUN O
from ADP O
equine ADJ O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT O
PBMC PROPN B-AC
) PUNCT O
using VERB O
an DET O
fluorescent ADJ O
beads NOUN O
- NOUN O
based VERB O
equine ADJ O
cytokine NOUN O
multiplex NOUN O
assays NOUN O
for ADP O
IFN NOUN O
- NOUN O
α NOUN O
, PUNCT O
IL-4 NOUN B-AC
, PUNCT O
IL-10 NOUN O
, PUNCT O
IL-17 NOUN O
and CCONJ O
IFN NOUN B-AC
- NOUN B-AC
γ NOUN B-AC
as SCONJ O
previously ADV O
described VERB O
[ PUNCT O
38 NUM O
] PUNCT O
. PUNCT O

Study NOUN O
villages NOUN O
are AUX O
shown VERB O
with ADP O
dark ADJ O
brown ADJ O
dots NOUN O
; PUNCT O
villages NOUN O
with ADP O
light ADJ B-LF
trap NOUN I-LF
captures NOUN I-LF
( PUNCT O
LTC PROPN B-AC
) PUNCT O
are AUX O
marked VERB O
with ADP O
light ADJ O
brown ADJ O
dots NOUN O
. PUNCT O

The DET O
HCP PROPN B-AC
dataset NOUN O
allowed VERB O
us PRON O
to ADP O
investigate VERB O
how SCONJ O
the DET O
magnitude NOUN O
of ADP O
the DET O
brain NOUN O
’s PART O
global ADJ B-LF
signal NOUN I-LF
( PUNCT O
GS PROPN B-AC
) PUNCT O
fluctuation NOUN O
( PUNCT O
also ADV O
referred VERB O
to ADP O
as ADP O
amplitude NOUN O
in ADP O
the DET O
literature NOUN O
) PUNCT O
varies VERB O
throughout ADP O
the DET O
day NOUN O
. PUNCT O

In ADP O
the DET O
NHIRD PROPN B-AC
, PUNCT O
disease NOUN O
identification NOUN O
is AUX O
based VERB O
on ADP O
the DET O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
, PUNCT I-LF
9th ADJ I-LF
Revision PROPN I-LF
, PUNCT I-LF
Clinical PROPN I-LF
Modification PROPN I-LF
( PUNCT O
ICD-9 PROPN B-AC
- PUNCT B-AC
CM PROPN B-AC
) PUNCT O
, PUNCT O
which PRON O
was AUX O
coded VERB O
by ADP O
a DET O
qualified ADJ O
clinician NOUN O
according VERB O
to ADP O
the DET O
clinical ADJ O
assessment NOUN O
, PUNCT O
including VERB O
disease NOUN O
presentation NOUN O
, PUNCT O
physical ADJ O
findings NOUN O
and CCONJ O
laboratory NOUN O
tests NOUN O
. PUNCT O

We PRON O
also ADV O
examined VERB O
the DET O
role NOUN O
of ADP O
TNF PROPN B-LF
Receptor PROPN I-LF
Associated PROPN I-LF
Factors PROPN I-LF
( PUNCT O
TRAF PROPN B-AC
) PUNCT O
in ADP O
the DET O
regulation NOUN O
of ADP O
CX3CL1 PROPN O
and CCONJ O
TNF PROPN O
- PUNCT O
α NOUN O
expression NOUN O
. PUNCT O

Se NOUN B-AC
status NOUN O
was AUX O
determined VERB O
by ADP O
measuring VERB O
both CCONJ O
selenoprotein NOUN B-LF
P NOUN I-LF
( PUNCT O
SePP PROPN B-AC
) PUNCT O
and CCONJ O
plasma NOUN O
Se NOUN B-AC
concentrations NOUN O
. PUNCT O

The DET O
underlying VERB O
numerical ADJ O
data NOUN O
can AUX O
be AUX O
found VERB O
in ADP O
S1 PROPN O
and CCONJ O
S2 PROPN O
Data NOUN O
. PUNCT O
3 NUM B-AC
' NOUN B-AC
UTR NOUN B-AC
, PUNCT O
3 NUM O
' NOUN O
untranslated VERB B-LF
region NOUN I-LF
; PUNCT O
dpf NOUN B-AC
, PUNCT O
days NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT O
F NOUN B-AC
- NOUN B-AC
actin NOUN B-AC
, PUNCT O
filamentous ADJ B-LF
actin NOUN I-LF
; PUNCT O
smFISH PROPN B-AC
, PUNCT O
single ADJ B-LF
molecule NOUN I-LF
fluorescent ADJ I-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
. PUNCT O

ASCVD NOUN B-AC
, PUNCT O
atherosclerotic ADJ B-LF
cardiovascular ADJ I-LF
disease NOUN I-LF
; PUNCT O
AUC PROPN B-AC
, PUNCT O
areas NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
; PUNCT O
CACS PROPN B-AC
, PUNCT O
coronary ADJ B-LF
artery NOUN I-LF
calcium NOUN I-LF
scores NOUN I-LF
; PUNCT O
CAP PROPN B-AC
, PUNCT O
calcified VERB B-LF
plaque NOUN I-LF
; PUNCT O
NCAP PROPN B-AC
, PUNCT O
noncalcified ADJ B-LF
plaque NOUN I-LF
; PUNCT O
MCAP PROPN B-AC
, PUNCT O
mixed VERB B-LF
plaque NOUN I-LF
. PUNCT O

We PRON O
initially ADV O
observed VERB O
that SCONJ O
GCs NOUN B-AC
migrate VERB O
in ADP O
chain NOUN O
- PUNCT O
like ADJ O
structures NOUN O
toward ADP O
the DET O
midbrain NOUN B-LF
- PUNCT I-LF
hindbrain NOUN I-LF
boundary NOUN I-LF
( PUNCT O
MHB PROPN B-AC
) PUNCT O
. PUNCT O
To PART O
investigate VERB O
these DET O
cellular ADJ O
interactions NOUN O
in ADP O
more ADJ O
detail NOUN O
, PUNCT O
we PRON O
first ADV O
addressed VERB O
whether SCONJ O
glial ADJ O
cells NOUN O
are AUX O
present ADJ O
in ADP O
the DET O
zebrafish NOUN O
cerebellum NOUN O
and CCONJ O
hindbrain NOUN O
before ADP O
and CCONJ O
during ADP O
onset NOUN O
of ADP O
GC NOUN B-AC
migration NOUN O
( PUNCT O
36 NUM O
hpf NOUN B-AC
, PUNCT O
48 NUM O
hpf NOUN B-AC
) PUNCT O
. PUNCT O

Other ADJ O
interactions NOUN O
occur VERB O
with ADP O
EGF PROPN B-AC
( PUNCT O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
) PUNCT O
and CCONJ O
its PRON O
respective ADJ O
receptor NOUN O
( PUNCT O
EGFR PROPN B-AC
) PUNCT O
, PUNCT O
CFTR PROPN B-AC
( PUNCT O
ATP NOUN O
- PUNCT O
binding VERB O
cassette NOUN O
sub NOUN O
- PUNCT O
family NOUN O
C PROPN O
, PUNCT O
member NOUN O
7 NUM O
) PUNCT O
, PUNCT O
M6PR PROPN B-AC
( PUNCT O
mannose-6 NOUN O
- PUNCT O
phosphate NOUN O
receptor NOUN O
, PUNCT O
cation NOUN O
dependent ADJ O
) PUNCT O
, PUNCT O
RAB5A PROPN B-AC
( PUNCT O
member NOUN B-LF
RAS PROPN I-LF
oncogene NOUN I-LF
family NOUN I-LF
) PUNCT O
and CCONJ O
APOB PROPN B-AC
( PUNCT O
apolipoprotein NOUN B-LF
B NOUN I-LF
) PUNCT O
. PUNCT O

PKA PROPN B-AC
holoenzymes NOUN O
, PUNCT O
especially ADV O
RII PROPN O
holoenzymes NOUN O
, PUNCT O
typically ADV O
bind VERB O
with ADP O
high ADJ O
affinity NOUN O
to ADP O
an DET O
amphipathic ADJ O
helix NOUN O
that PRON O
is AUX O
embedded VERB O
in ADP O
scaffold NOUN O
proteins NOUN O
referred VERB O
to ADP O
as ADP O
A PROPN B-LF
- PUNCT I-LF
Kinase PROPN I-LF
- PUNCT I-LF
Anchoring PROPN I-LF
Proteins PROPN I-LF
( PUNCT O
AKAPs PROPN B-AC
) PUNCT O
through ADP O
their PRON O
D NOUN B-AC
/ SYM B-AC
D NOUN B-AC
domains NOUN O
[ X O
35–37 NUM O
] PUNCT O
. PUNCT O

Cytology NOUN O
results NOUN O
were AUX O
reported VERB O
according VERB O
to ADP O
the DET O
Bethesda PROPN O
System PROPN O
2001 NUM O
and CCONJ O
CC PROPN B-AC
cases NOUN O
were AUX O
staged VERB O
according VERB O
to ADP O
the DET O
International PROPN B-LF
Federation PROPN I-LF
of ADP I-LF
Gynecology PROPN I-LF
and CCONJ I-LF
Obstetrics PROPN I-LF
( PUNCT O
FIGO PROPN B-AC
) PUNCT O
. PUNCT O

To PART O
address VERB O
this DET O
issue NOUN O
, PUNCT O
we PRON O
utilized VERB O
clockGAL4 PROPN O
[ PUNCT O
25 NUM O
] PUNCT O
, PUNCT O
which PRON O
drives VERB O
broad ADJ O
expression NOUN O
among ADP O
all DET O
major ADJ O
circadian ADJ O
neuronal ADJ O
groups NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
but CCONJ O
relatively ADV O
limited ADJ O
noncircadian ADJ O
expression NOUN O
, PUNCT O
including VERB O
the DET O
pars NOUN B-LF
intercerebralis NOUN I-LF
( PUNCT O
PI PROPN B-AC
) PUNCT O
and CCONJ O
cells NOUN O
surrounding VERB O
circadian ADJ O
neurons NOUN O
[ PUNCT O
16 NUM O
] PUNCT O
. PUNCT O

In ADP O
order NOUN O
to PART O
directly ADV O
visualize VERB O
the DET O
destabilization NOUN O
dependent ADJ O
on ADP O
nucleotide NOUN O
state NOUN O
, PUNCT O
we PRON O
developed VERB O
a DET O
single ADJ O
molecule NOUN O
assay NOUN O
using VERB O
FtsZ PROPN O
- PUNCT O
YFP PROPN B-AC
- PUNCT O
mts NOUN B-AC
incubated VERB O
with ADP O
fluorescently ADV O
labeled VERB O
nanobodies NOUN O
( PUNCT O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
[ SYM O
GFP]-Booster PROPN B-AC
- PUNCT O
Atto647N PROPN O
, PUNCT O
see VERB O
Materials NOUN O
and CCONJ O
methods NOUN O
) PUNCT O
( PUNCT O
Fig NOUN O
5A NOUN O
) PUNCT O
to PART O
investigate VERB O
the DET O
protein NOUN O
turnover NOUN O
at ADP O
the DET O
membrane NOUN O
, PUNCT O
implying VERB O
that SCONJ O
faster ADJ O
disassembly NOUN O
suggests VERB O
higher ADJ O
destabilization NOUN O
. PUNCT O

Our PRON O
large ADJ O
sample NOUN O
size NOUN O
allowed VERB O
us PRON O
to ADP O
calculate VERB O
hazard NOUN B-LF
ratios NOUN I-LF
( PUNCT O
HRs NOUN B-AC
) PUNCT O
of ADP O
mortality NOUN O
and CCONJ O
years NOUN O
of ADP O
life NOUN O
gained VERB O
after ADP O
age NOUN O
40 NUM O
according VERB O
to ADP O
fine ADJ O
gradations NOUN O
of ADP O
activity NOUN O
levels NOUN O
and CCONJ O
in ADP O
subgroups NOUN O
for ADP O
which PRON O
, PUNCT O
to ADP O
our PRON O
knowledge NOUN O
, PUNCT O
no DET O
prior ADJ O
estimates NOUN O
are AUX O
available ADJ O
, PUNCT O
such ADJ O
as ADP O
black ADJ O
individuals NOUN O
, PUNCT O
smokers NOUN O
, PUNCT O
and CCONJ O
persons NOUN O
with ADP O
a DET O
history NOUN O
of ADP O
cancer NOUN O
and/or CCONJ O
heart NOUN O
disease NOUN O
. PUNCT O

Abbreviations NOUN O
: PUNCT O
8 NUM B-AC
- NOUN B-AC
OHdG NOUN B-AC
: PUNCT O
8 NUM O
- NOUN O
hydroxy-2′-deoxyguanosine NOUN O
; PUNCT O
8 NUM O
- NOUN O
iso NOUN B-AC
- NOUN B-AC
PGF2a NOUN B-AC
: PUNCT O
8 NUM O
- NOUN O
iso NOUN O
- NOUN O
prostaglandin NOUN O
F2a NOUN O
; PUNCT O
MDA NOUN B-AC
: PUNCT O
malondialdehyde NOUN B-LF
; PUNCT O
6 NUM B-AC
- NOUN B-AC
CN NOUN B-AC
: PUNCT O
6 NUM B-LF
- NOUN I-LF
chloronicotinic ADJ I-LF
acid NOUN I-LF
; PUNCT O
CI NOUN O
: PUNCT O
confidence NOUN O
interval NOUN O

We PRON O
investigated VERB O
the DET O
participation NOUN O
of ADP O
mitogen NOUN O
- PUNCT O
activated VERB O
protein NOUN O
kinase NOUN O
kinase NOUN O
( PUNCT O
MEK PROPN B-AC
) PUNCT O
kinase NOUN O
1 NUM O
( PUNCT O
MEKK1)/MEK1 PROPN B-AC
/ SYM O
ERK1 PROPN O
/ SYM O
GLI-1/2 PROPN O
and CCONJ O
activator NOUN B-LF
protein-1 NOUN I-LF
( PUNCT O
AP-1 PROPN B-AC
) PUNCT O
signaling NOUN O
in ADP O
hypoxia NOUN O
- PUNCT O
induced VERB O
CTGF PROPN B-AC
expression NOUN O
in ADP O
human ADJ O
lung NOUN O
fibroblasts NOUN O
. PUNCT O

HFD PROPN B-AC
stands VERB O
for ADP O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
. PUNCT O

Therefore ADV O
, PUNCT O
we PRON O
performed VERB O
a DET O
FTIR PROPN B-AC
investigation NOUN O
on ADP O
paraffin NOUN O
sections NOUN O
of ADP O
human ADJ O
hands NOUN O
by ADP O
principle ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT O
PCA NOUN B-AC
) PUNCT O
in ADP O
order NOUN O
to PART O
determine VERB O
variance NOUN O
of ADP O
protein NOUN O
structures NOUN O
between ADP O
electrical ADJ O
mark NOUN O
and CCONJ O
normal ADJ O
skin NOUN O
. PUNCT O

D NOUN B-AC
/ SYM B-AC
R NOUN B-AC
, PUNCT O
dangerous ADJ B-LF
and CCONJ I-LF
rich ADJ I-LF
; PUNCT O
ITI NOUN O
, PUNCT O
intertrial ADJ O
interval NOUN O
; PUNCT O
S NOUN B-AC
/ SYM B-AC
P NOUN B-AC
, PUNCT O
safe ADJ B-LF
and CCONJ I-LF
poor ADJ I-LF
; PUNCT O
S NOUN B-AC
/ SYM B-AC
R NOUN B-AC
, PUNCT O
safe ADJ B-LF
and CCONJ I-LF
rich ADJ I-LF
. PUNCT O

We PRON O
used VERB O
the DET O
data NOUN O
from ADP O
the DET O
cluster NOUN O
- PUNCT O
randomized VERB O
cross ADJ O
- PUNCT O
sectional ADJ O
Endoscopic PROPN B-LF
Quality PROPN I-LF
Improvement PROPN I-LF
Program-3 PROPN I-LF
( PUNCT O
EQUIP-3 PROPN B-AC
) PUNCT O
study NOUN O
( PUNCT O
Clinical PROPN O
Trials PROPN O
Registration PROPN O
: PUNCT O
NCT02325635 NUM O
) PUNCT O
that PRON O
ran VERB O
from ADP O
September PROPN O
2013 NUM O
until ADP O
January PROPN O
2015.[9 NUM O
] PUNCT O
The DET O
EQUIP-3 PROPN B-AC
study NOUN O
was AUX O
approved VERB O
by ADP O
the DET O
Mayo PROPN O
Clinic PROPN O
Institutional PROPN O
Review PROPN O
Board PROPN O
and CCONJ O
was AUX O
considered VERB O
minimal ADJ O
risk NOUN O
and CCONJ O
exempt ADJ O
from ADP O
patient NOUN O
- PUNCT O
level NOUN O
consent.[9 NOUN O
] PUNCT O
In ADP O
the DET O
EQUIP-3 PROPN B-AC
study NOUN O
centers NOUN O
were AUX O
randomized VERB O
, PUNCT O
after ADP O
a DET O
lead VERB O
- PUNCT O
in ADP O
phase NOUN O
, PUNCT O
to PART O
receive VERB O
a DET O
quality NOUN O
improvement NOUN O
program NOUN O
aimed VERB O
at ADP O
increasing VERB O
the DET O
ADR PROPN B-AC
or CCONJ O
no DET O
intervention NOUN O
. PUNCT O

Intracranial ADJ B-LF
pressure NOUN I-LF
( PUNCT O
ICP PROPN B-AC
) PUNCT O
monitoring NOUN O
is AUX O
necessary ADJ O
in ADP O
many ADJ O
clinical ADJ O
scenarios NOUN O
. PUNCT O

Prostate NOUN B-LF
cancer NOUN I-LF
( PUNCT O
PCa NOUN B-AC
) PUNCT O
poses VERB O
a DET O
major ADJ O
health NOUN O
concern NOUN O
in ADP O
men NOUN O
worldwide ADV O
. PUNCT O

This DET O
score NOUN O
was AUX O
called VERB O
the DET O
Perturbation PROPN B-LF
Score PROPN I-LF
( PUNCT O
PS PROPN B-AC
; PUNCT O
PScp PROPN O
, PUNCT O
d NOUN O
being AUX O
the DET O
perturbation NOUN O
experimented VERB O
by ADP O
pathway NOUN O
p NOUN O
during ADP O
the DET O
manifestation NOUN O
of ADP O
disease NOUN O
d NOUN O
on ADP O
cell NOUN O
type NOUN O
c NOUN O
) PUNCT O
. PUNCT O

The DET O
Charlson PROPN B-LF
Comorbidity PROPN I-LF
Index PROPN I-LF
( PUNCT O
CCI PROPN B-AC
) PUNCT O
was AUX O
calculated VERB O
electronically.[22 PUNCT O
] PUNCT O
Sepsis NOUN O
was AUX O
identified VERB O
using VERB O
a DET O
previously ADV O
- PUNCT O
validated VERB O
electronic ADJ O
algorithm.[23 NOUN O
] PUNCT O
Relevant ADJ O
cardiovascular ADJ O
hospital NOUN O
discharge NOUN O
diagnoses NOUN O
were AUX O
determined VERB O
using VERB O
ICD-9 PROPN O
diagnostic ADJ O
codes NOUN O
. PUNCT O

To PART O
converge VERB O
on ADP O
stable ADJ O
model NOUN O
output NOUN O
, PUNCT O
we PRON O
run VERB O
a DET O
simulated VERB O
cohort NOUN O
of ADP O
1 NUM O
million NUM O
patients NOUN O
infected VERB O
with ADP O
HIV PROPN O
. PUNCT O
Because SCONJ O
the DET O
cohort NOUN O
size NOUN O
can AUX O
be AUX O
varied VERB O
in ADP O
the DET O
simulation NOUN O
— PUNCT O
i.e. X O
, PUNCT O
we PRON O
might AUX O
also ADV O
simulate VERB O
2 NUM O
million NUM O
or CCONJ O
5 NUM O
million NUM O
patients—95 NOUN O
% NOUN O
confidence NOUN O
intervals NOUN O
and CCONJ O
standard ADJ B-LF
deviations NOUN I-LF
( PUNCT O
SDs NOUN B-AC
) PUNCT O
do AUX O
not PART O
adequately ADV O
capture VERB O
uncertainty NOUN O
in ADP O
simulation NOUN O
modeling NOUN O
. PUNCT O

LRI NOUN B-AC
, PUNCT O
lower ADJ B-LF
respiratory ADJ I-LF
infection NOUN I-LF
. PUNCT O

FWP PROPN B-AC
mechanism NOUN O
of ADP O
action NOUN O
could AUX O
possibly ADV O
be AUX O
mediated VERB O
by ADP O
an DET O
elevation NOUN O
of ADP O
GSH PROPN O
concentration NOUN O
and CCONJ O
a DET O
decreased VERB O
glutathione NOUN B-LF
redox NOUN I-LF
ratio NOUN I-LF
( PUNCT O
GSSG NOUN B-AC
/ SYM B-AC
GSH PROPN B-AC
) PUNCT O
ratio NOUN O
which PRON O
leads VERB O
to ADP O
a DET O
suppression NOUN O
of ADP O
OxS PROPN B-AC
and CCONJ O
the DET O
decreased VERB O
release NOUN O
of ADP O
8 NUM B-AC
- PUNCT B-AC
EPI NOUN B-AC
. PUNCT O
Hydrolyzed VERB O
whey NOUN O
protein NOUN O
isolate NOUN O
can AUX O
increase VERB O
intracellular ADJ O
glutathione NOUN O
level NOUN O
in ADP O
human ADJ O
prostate NOUN O
epithelial ADJ O
cell NOUN O
line NOUN O
and CCONJ O
protect VERB O
form NOUN O
oxidant NOUN O
induced VERB O
cell NOUN O
death[16 NOUN O
] PUNCT O
. PUNCT O

Twenty NUM O
- PUNCT O
one NUM O
studies NOUN O
( PUNCT O
44 NUM O
% PUNCT O
) PUNCT O
analyzed VERB O
birthweight NOUN O
, PUNCT O
low ADJ B-LF
birthweight NOUN I-LF
( PUNCT O
LBW PROPN B-AC
) PUNCT O
, PUNCT O
and CCONJ O
small ADJ O
for ADP O
gestational ADJ O
age NOUN O
. PUNCT O