Within ADP B-O
amoebae NOUN B-O
and CCONJ B-O
macrophages NOUN B-O
, PUNCT B-O
L. PROPN B-O
pneumophila PROPN B-O
replicates VERB B-O
with ADP B-O
a DET B-O
similar ADJ B-O
mechanism NOUN B-O
by ADP B-O
forming VERB B-O
a DET B-O
membrane NOUN B-O
- PUNCT B-O
bound VERB B-O
compartment NOUN B-O
, PUNCT B-O
the DET B-O
Legionella PROPN B-O
- PUNCT B-O
containing VERB B-O
vacuole NOUN B-O
( PUNCT B-O
LCV PROPN B-AC
) PUNCT B-O
. PUNCT B-O
Formation NOUN B-O
of ADP B-O
the DET B-O
LCV PROPN B-AC
is AUX B-O
not PART B-O
well ADV B-O
defined VERB B-O
, PUNCT B-O
but CCONJ B-O
requires VERB B-O
that SCONJ B-O
L. PROPN B-O
pneumophila PROPN B-O
injects VERB B-O
proteins NOUN B-O
into ADP B-O
the DET B-O
host NOUN B-O
cell NOUN B-O
via ADP B-O
the DET B-O
intracellular ADJ B-LF
multiplication NOUN I-LF
( PUNCT B-O
Icm)/defective ADJ B-LF
organelle NOUN I-LF
trafficking NOUN I-LF
( PUNCT B-O
Dot NOUN B-AC
) PUNCT B-O
secretion NOUN B-O
system NOUN B-O
. PUNCT B-O

L NOUN B-O
16 NUM B-O
: PUNCT B-O
Would AUX B-O
contraceptive ADJ B-LF
prevalence NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
CPR NOUN B-AC
) PUNCT B-O
or CCONJ B-O
even ADV B-O
modern ADJ B-O
CPR NOUN B-AC
( PUNCT B-O
mCPR NOUN B-O
) PUNCT B-O
be AUX B-O
more ADV B-O
appropriate ADJ B-O
? PUNCT B-O

Stable ADJ B-O
metabolically ADV B-LF
unhealthy ADJ I-LF
overweight NOUN I-LF
or CCONJ I-LF
obesity NOUN I-LF
( PUNCT B-O
MUOO PROPN B-AC
) PUNCT B-O
( PUNCT B-O
HR NOUN B-AC
2.22 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
[ X B-O
CI NOUN B-AC
] X B-O
2.00–2.47 NUM B-O
, PUNCT B-O
p NOUN B-O
< ADP B-O
0.001 NUM B-O
) PUNCT B-O
and CCONJ B-O
transition NOUN B-O
from ADP B-O
metabolically ADV B-O
healthy ADJ B-O
to ADP B-O
unhealthy ADJ B-O
status NOUN B-O
( PUNCT B-O
HR NOUN B-AC
1.53 NUM B-O
, PUNCT B-O
1.34–1.75 NUM B-O
, PUNCT B-O
p NOUN B-O
< ADP B-O
0.001 NUM B-O
) PUNCT B-O
were AUX B-O
associated VERB B-O
with ADP B-O
higher ADJ B-O
risk NOUN B-O
for ADP B-O
MVE PROPN B-AC
, PUNCT B-O
compared VERB B-O
with ADP B-O
stable ADJ B-O
healthy ADJ B-O
normal ADJ B-O
weight NOUN B-O
. PUNCT B-O

At ADP B-O
present NOUN B-O
, PUNCT B-O
many ADJ B-O
disease NOUN B-O
- PUNCT B-O
surveillance NOUN B-O
systems NOUN B-O
rely VERB B-O
either CCONJ B-O
on ADP B-O
comparing VERB B-O
current ADJ B-O
counts NOUN B-O
with ADP B-O
historical ADJ B-O
time NOUN B-O
- PUNCT B-O
series NOUN B-O
models NOUN B-O
, PUNCT B-O
or CCONJ B-O
on ADP B-O
identifying VERB B-O
sudden ADJ B-O
increases NOUN B-O
in ADP B-O
utilization NOUN B-O
( PUNCT B-O
e.g. X B-O
, PUNCT B-O
cumulative ADJ B-LF
sum NOUN I-LF
[ X B-O
CUSUM X B-AC
] PUNCT B-O
or CCONJ B-O
exponential ADJ B-LF
weighted VERB I-LF
moving VERB I-LF
average NOUN I-LF
[ X B-O
EWMA PROPN B-AC
] PUNCT B-O
[ X B-O
9,10 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

Also ADV B-O
see VERB B-O
Fig PROPN B-O
4 NUM B-O
. PUNCT B-O
dpIns1 NOUN B-O
, PUNCT B-O
dorsal ADJ B-O
posterior ADJ B-O
insula NOUN B-O
cluster NOUN B-O
1 NUM B-O
; PUNCT B-O
PO1 NOUN B-AC
, PUNCT B-O
parietal ADJ B-LF
operculum NOUN I-LF
cluster NOUN I-LF
1 NUM I-LF
; PUNCT B-O
STG1 NOUN B-O
, PUNCT B-O
superior ADJ B-O
temporal ADJ B-O
gyrus NOUN B-O
cluster NOUN B-O
1 NUM B-O
. PUNCT B-O

In ADP B-O
C. PROPN B-O
elegans NOUN B-O
, PUNCT B-O
the DET B-O
prevailing VERB B-O
response NOUN B-O
to ADP B-O
mitochondrial ADJ B-O
stress NOUN B-O
is AUX B-O
the DET B-O
mitochondrial ADJ B-LF
unfolded VERB I-LF
protein NOUN I-LF
response NOUN I-LF
( PUNCT B-O
UPRmt NOUN B-AC
) PUNCT B-O
[ X B-O
16–19 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
principal ADJ B-O
catabolic ADJ B-O
fate NOUN B-O
of ADP B-O
cholesterol NOUN B-O
is AUX B-O
its PRON B-O
conversion NOUN B-O
to ADP B-O
the DET B-O
primary ADJ B-O
bile NOUN B-LF
acids NOUN I-LF
( PUNCT B-O
BAs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
cholic NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
CA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
chenodeoxycholic NOUN B-LF
acid NOUN I-LF
( PUNCT B-O
CDCA NOUN B-AC
) PUNCT B-O
through ADP B-O
BBB NOUN B-AC
- PUNCT B-O
permeable ADJ B-O
intermediate ADJ B-O
metabolites NOUN B-O
called VERB B-O
oxysterols NOUN B-O
( PUNCT B-O
S1 PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

We PRON B-O
performed VERB B-O
one NUM B-O
- ADJ B-O
way NOUN B-O
analysis NOUN B-LF
of ADP I-LF
variance NOUN I-LF
( PUNCT B-O
ANOVA NOUN B-AC
) PUNCT B-O
with ADP B-O
Tukey PROPN B-O
's PART B-O
HSD NOUN B-O
post ADJ B-O
- ADJ B-O
hoc ADJ B-O
test VERB B-O
to PART B-O
test VERB B-O
the DET B-O
significance NOUN B-O
in ADP B-O
comparisons NOUN B-O
with ADP B-O
more ADJ B-O
than ADP B-O
2 NUM B-O
groups NOUN B-O
. PUNCT B-O

The DET B-O
types NOUN B-O
of ADP B-O
variability NOUN B-O
responsiveness NOUN B-O
tested VERB B-O
were AUX B-O
SL PROPN B-AC
variability NOUN B-O
and CCONJ B-O
MTC PROPN B-AC
variability NOUN B-O
using VERB B-O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT B-O
SD PROPN B-AC
) PUNCT B-O
and CCONJ B-O
CV NOUN B-AC
, PUNCT B-O
and CCONJ B-O
SBS PROPN B-AC
- PUNCT B-AC
FTA NOUN B-AC
variability NOUN B-O
. PUNCT B-O

We PRON B-O
then ADV B-O
investigated VERB B-O
the DET B-O
DIP2A PROPN B-AC
expression NOUN B-O
pattern NOUN B-O
in ADP B-O
the DET B-O
adult ADJ B-O
cortex NOUN B-O
with ADP B-O
Dip2a NOUN B-LF
- NOUN I-LF
β NOUN I-LF
- NOUN I-LF
galactosidase NOUN I-LF
( PUNCT B-O
LacZ PROPN B-AC
) PUNCT B-O
mice NOUN B-O
, PUNCT B-O
in ADP B-O
which PRON B-O
LacZ PROPN B-AC
was AUX B-O
designed VERB B-O
with ADP B-O
nucleus NOUN B-O
expression NOUN B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
47 NUM B-O
- PUNCT B-O
item NOUN B-O
PMH PROPN B-AC
instrument NOUN B-O
consists VERB B-O
of ADP B-O
six NUM B-O
domains NOUN B-O
of ADP B-O
mental ADJ B-O
health NOUN B-O
; PUNCT B-O
general ADJ B-LF
coping NOUN I-LF
( PUNCT B-O
GC PROPN B-AC
, PUNCT B-O
9 NUM B-O
items NOUN B-O
) PUNCT B-O
, PUNCT B-O
emotional ADJ B-LF
support NOUN I-LF
( PUNCT B-O
ES PROPN B-AC
, PUNCT B-O
7 NUM B-O
items NOUN B-O
) PUNCT B-O
, PUNCT B-O
spirituality NOUN B-O
( PUNCT B-O
7 NUM B-O
items NOUN B-O
) PUNCT B-O
, PUNCT B-O
interpersonal ADJ B-LF
skills NOUN I-LF
( PUNCT B-O
IS PROPN B-AC
, PUNCT B-O
9 NUM B-O
items NOUN B-O
) PUNCT B-O
, PUNCT B-O
personal ADJ B-LF
growth NOUN I-LF
and CCONJ I-LF
autonomy NOUN I-LF
( PUNCT B-O
PGA PROPN B-AC
, PUNCT B-O
10 NUM B-O
items NOUN B-O
) PUNCT B-O
and CCONJ B-O
global ADJ B-LF
affect NOUN I-LF
( PUNCT B-O
GA PROPN B-AC
, PUNCT B-O
5 NUM B-O
items NOUN B-O
) PUNCT B-O
[ PUNCT B-O
14 NUM B-O
] PUNCT B-O
. PUNCT B-O

Preliminary ADJ B-O
results NOUN B-O
show VERB B-O
that SCONJ B-O
a DET B-O
tax NOUN B-O
levied VERB B-O
on ADP B-O
sugar NOUN B-LF
- PUNCT I-LF
sweetened VERB I-LF
beverages NOUN I-LF
( PUNCT B-O
SSBs PROPN B-AC
) PUNCT B-O
by ADP B-O
the DET B-O
Portuguese ADJ B-O
government NOUN B-O
in ADP B-O
2017 NUM B-O
led VERB B-O
to ADP B-O
a DET B-O
drop NOUN B-O
in ADP B-O
sales NOUN B-O
and CCONJ B-O
reformulation NOUN B-O
of ADP B-O
these DET B-O
products NOUN B-O
. PUNCT B-O

TB NOUN B-AC
, PUNCT B-O
tuberculosis NOUN B-LF
; PUNCT B-O
TST NOUN B-AC
, PUNCT B-O
tuberculin NOUN B-LF
skin NOUN I-LF
testing NOUN I-LF
. PUNCT B-O

LOS PROPN B-AC
= PUNCT B-O
late ADJ B-O
onset NOUN B-O
sepsis NOUN B-O
, PUNCT B-O
NEC PROPN B-AC
= PUNCT B-O
necrotizing VERB B-LF
enterocolitis NOUN I-LF

The DET B-O
data NOUN B-O
of ADP B-O
the DET B-O
ENMERE-2016 PROPN B-AC
( PUNCT B-O
Peruvian PROPN B-LF
Medical PROPN I-LF
Residents PROPN I-LF
National PROPN I-LF
Survey-2016 PROPN I-LF
) PUNCT B-O
belongs VERB B-O
to ADP B-O
the DET B-O
National PROPN B-O
Committee PROPN B-O
of ADP B-O
Peruvian PROPN B-O
Medical PROPN B-O
Residency PROPN B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
understand VERB B-O
how SCONJ B-O
p84 NOUN B-O
could AUX B-O
mask VERB B-O
Ser582 PROPN B-O
phosphorylation NOUN B-O
, PUNCT B-O
and CCONJ B-O
to PART B-O
map VERB B-O
the DET B-O
p110γ NOUN B-O
- PUNCT B-O
p84 NOUN B-O
contact NOUN B-O
interface NOUN B-O
, PUNCT B-O
hydrogen NOUN B-LF
deuterium NOUN I-LF
exchange NOUN I-LF
mass NOUN I-LF
spectrometry NOUN I-LF
( PUNCT B-O
HDX NOUN B-AC
- PUNCT B-AC
MS PROPN B-AC
) PUNCT B-O
was AUX B-O
used VERB B-O
. PUNCT B-O

FPG PROPN B-AC
, PUNCT B-O
fasting VERB B-LF
plasma NOUN I-LF
glucose NOUN I-LF
; PUNCT B-O
TNFi PROPN B-AC
, PUNCT B-O
tumour NOUN B-O
necrosis NOUN B-O
factor NOUN B-O
inhibitor NOUN B-O
. PUNCT B-O

Among ADP B-O
HNSCCs PROPN B-O
, PUNCT B-O
oral ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinomas NOUN I-LF
( PUNCT B-O
OSCCs PROPN B-AC
) PUNCT B-O
include VERB B-O
several ADJ B-O
anatomical ADJ B-O
locations NOUN B-O
of ADP B-O
the DET B-O
oral ADJ B-O
cavity NOUN B-O
, PUNCT B-O
but CCONJ B-O
exclude VERB B-O
the DET B-O
oropharynx NOUN B-O
. PUNCT B-O

We PRON B-O
then ADV B-O
did VERB B-O
the DET B-O
reverse ADJ B-O
experiment NOUN B-O
, PUNCT B-O
i.e. X B-O
, PUNCT B-O
we PRON B-O
coexpressed VERB B-O
wild ADJ B-LF
type NOUN I-LF
( PUNCT B-O
WT PROPN B-AC
) PUNCT B-O
STAT1 PROPN B-O
and CCONJ B-O
mutant ADJ B-O
STAT2 PROPN B-O
that PRON B-O
harbored VERB B-O
alanine NOUN B-O
in ADP B-O
the DET B-O
STAT1 PROPN B-O
F77 PROPN B-O
homologous ADJ B-O
position NOUN B-O
leucine NOUN B-O
82 NUM B-O
( PUNCT B-O
Fig PROPN B-O
1B NOUN B-O
, PUNCT B-O
panels NOUN B-O
11 NUM B-O
and CCONJ B-O
12 NUM B-O
) PUNCT B-O
or CCONJ B-O
the DET B-O
functionally ADV B-O
equivalent ADJ B-O
double ADJ B-O
mutation NOUN B-O
LL81,82AA NUM B-O
( PUNCT B-O
S3 PROPN B-O
Fig PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
finding NOUN B-O
of ADP B-O
an DET B-O
overall ADJ B-O
rise NOUN B-O
in ADP B-O
opioid NOUN B-O
prescribing NOUN B-O
is AUX B-O
complementary ADJ B-O
to ADP B-O
a DET B-O
recent ADJ B-O
study NOUN B-O
using VERB B-O
National PROPN B-LF
Health PROPN I-LF
Service PROPN I-LF
( PUNCT B-O
NHS PROPN B-AC
) PUNCT B-O
digital ADJ B-O
pharmacy NOUN B-O
claims NOUN B-O
data NOUN B-O
demonstrating VERB B-O
a DET B-O
34 NUM B-O
% NOUN B-O
increase NOUN B-O
in ADP B-O
opioid NOUN B-O
prescriptions NOUN B-O
between ADP B-O
1998 NUM B-O
and CCONJ B-O
2016 NUM B-O
[ PUNCT B-O
7 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
most ADJ B-O
patients NOUN B-O
, PUNCT B-O
preoperative ADJ B-O
levels NOUN B-O
of ADP B-O
serum ADJ B-O
follicle NOUN B-LF
- PUNCT I-LF
stimulating VERB I-LF
hormone NOUN I-LF
( PUNCT B-O
FSH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
leutenizing VERB B-LF
hormone NOUN I-LF
( PUNCT B-O
LH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
total ADJ B-O
testosterone NOUN B-O
were AUX B-O
measured VERB B-O
. PUNCT B-O

Lgl PROPN B-AC
binds VERB B-O
to PART B-O
atypical ADJ B-LF
protein NOUN I-LF
kinase NOUN I-LF
C PROPN I-LF
( PUNCT B-O
aPKC PROPN B-AC
) PUNCT B-O
and CCONJ B-O
Par6 PROPN B-O
, PUNCT B-O
and CCONJ B-O
this DET B-O
interaction NOUN B-O
has AUX B-O
been AUX B-O
shown VERB B-O
to PART B-O
regulate VERB B-O
the DET B-O
function NOUN B-O
of ADP B-O
Lgl PROPN B-AC
in ADP B-O
cell NOUN B-O
polarity NOUN B-O
[ PUNCT B-O
14],[15],[16 NUM B-O
] PUNCT B-O
. PUNCT B-O

IPTp PROPN B-AC
- PUNCT B-O
SP PROPN B-AC
has AUX B-O
been AUX B-O
shown VERB B-O
to PART B-O
reduce VERB B-O
low ADJ B-LF
birth NOUN I-LF
weight NOUN I-LF
( PUNCT B-O
LBW PROPN B-AC
) PUNCT B-O
deliveries NOUN B-O
and CCONJ B-O
maternal ADJ B-O
morbidity NOUN B-O
[ PUNCT B-O
1],[9 NUM B-O
] PUNCT B-O
. PUNCT B-O

A NOUN B-O
) PUNCT B-O
When SCONJ B-O
compared VERB B-O
to ADP B-O
their PRON B-O
control NOUN B-O
( PUNCT B-O
CypD+/+ PROPN B-AC
) PUNCT B-O
littermates NOUN B-O
, PUNCT B-O
BMSCs NOUN B-AC
from ADP B-O
CypD-/- PROPN B-AC
mice NOUN B-O
have VERB B-O
higher ADJ B-O
oxidative ADJ B-O
metabolism NOUN B-O
measured VERB B-O
with ADP B-O
both CCONJ B-O
CMXRos PROPN B-O
( PUNCT B-O
A NOUN B-O
) PUNCT B-O
and CCONJ B-O
via ADP B-O
oxygen NOUN B-LF
consumption NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
OCR PROPN B-AC
) PUNCT B-O
assay NOUN B-O
using VERB B-O
Seahorse PROPN B-O
XF PROPN B-O
technology NOUN B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
; PUNCT B-O
C X B-O
) PUNCT B-O
X NOUN B-O
- ADJ B-O
ray NOUN B-O
and CCONJ B-O
micro ADJ B-AC
- ADJ B-AC
CT ADJ B-AC
images NOUN B-O
of ADP B-O
spinal ADJ B-O
grafts NOUN B-O
at ADP B-O
D0 NOUN B-O
and CCONJ B-O
at ADP B-O
12 NUM B-O
wks NOUN B-O
post ADJ B-O
- ADJ B-O
surgery NOUN B-O
. PUNCT B-O

For ADP B-O
example NOUN B-O
, PUNCT B-O
oxylipins NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
prostaglandins NOUN B-O
, PUNCT B-O
including VERB B-O
prostaglandin NOUN B-LF
E2 PROPN I-LF
( PUNCT B-O
PGE2 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
leukotrienes NOUN B-O
play VERB B-O
a DET B-O
pivotal ADJ B-O
role NOUN B-O
in ADP B-O
the DET B-O
inflammatory ADJ B-O
response NOUN B-O
[ PUNCT B-O
12,13 NUM B-O
] PUNCT B-O
. PUNCT B-O

By ADP B-O
searching VERB B-O
a DET B-O
database NOUN B-O
of ADP B-O
pathogen NOUN B-O
proteins NOUN B-O
, PUNCT B-O
the DET B-O
researchers NOUN B-O
discovered VERB B-O
that SCONJ B-O
rotavirus NOUN B-O
protein NOUN B-O
VP-7 NOUN B-O
contains VERB B-O
a DET B-O
very ADV B-O
similar ADJ B-O
peptide NOUN B-O
; PUNCT B-O
a DET B-O
search NOUN B-O
of ADP B-O
a DET B-O
database NOUN B-O
of ADP B-O
human ADJ B-O
proteins NOUN B-O
indicated VERB B-O
that SCONJ B-O
celiac ADJ B-O
peptide NOUN B-O
also ADV B-O
resembles VERB B-O
peptides NOUN B-O
found VERB B-O
in ADP B-O
tissue NOUN B-O
transglutaminase NOUN B-O
, PUNCT B-O
Toll PROPN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
4 NUM I-LF
( PUNCT B-O
TLR4 PROPN B-AC
; PUNCT B-O
a DET B-O
protein NOUN B-O
involved VERB B-O
in ADP B-O
the DET B-O
innate ADJ B-O
immune ADJ B-O
response NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
several ADJ B-O
other ADJ B-O
self NOUN B-O
- PUNCT B-O
antigens NOUN B-O
. PUNCT B-O

Confocal ADJ B-O
microscopy NOUN B-O
analysis NOUN B-O
of ADP B-O
adoptively ADV B-O
transferred VERB B-O
TCR PROPN B-O
- NOUN B-O
transgenic ADJ B-O
CD8 PROPN B-O
+ NOUN B-O
T PROPN B-O
cells NOUN B-O
( PUNCT B-O
Spiky PROPN B-O
) PUNCT B-O
in ADP B-O
LNs PROPN B-AC
performed VERB B-O
on ADP B-O
day NOUN B-O
2 NUM B-O
post NOUN B-O
immunization NOUN B-O
with ADP B-O
DC PROPN B-AC
- NOUN B-O
targeting VERB B-O
viral ADJ B-O
particles NOUN B-O
. PUNCT B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
Zoom VERB B-O
- NOUN B-O
in ADP B-O
panels NOUN B-O
of ADP B-O
the DET B-O
area NOUN B-O
indicated VERB B-O
by ADP B-O
rectangle NOUN B-O
in ADP B-O
( PUNCT B-O
D NOUN B-O
) PUNCT B-O
. PUNCT B-O
Scale NOUN B-O
bars NOUN B-O
represent VERB B-O
30 NUM B-O
μm NOUN B-O
( PUNCT B-O
D NOUN B-O
) PUNCT B-O
and CCONJ B-O
10 NUM B-O
μm NOUN B-O
( PUNCT B-O
E NOUN B-O
) PUNCT B-O
. PUNCT B-O
Data NOUN B-O
represent VERB B-O
mean ADJ B-O
± ADJ B-O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean ADJ I-LF
( PUNCT B-O
SEM PROPN B-AC
) PUNCT B-O
for ADP B-O
6–20 NUM B-O
mice NOUN B-O
per ADP B-O
group NOUN B-O
from ADP B-O
three NUM B-O
independent ADJ B-O
experiments NOUN B-O
( PUNCT B-O
A NOUN B-O
– PUNCT B-O
B NOUN B-O
) PUNCT B-O
. PUNCT B-O
Data NOUN B-O
represent VERB B-O
mean ADJ B-O
± ADJ B-O
standard ADJ B-LF
deviation NOUN I-LF
( PUNCT B-O
SD NOUN B-AC
) PUNCT B-O
for ADP B-O
5–10 NUM B-O
datasets NOUN B-O
from ADP B-O
2–3 NUM B-O
mice NOUN B-O
per ADP B-O
group NOUN B-O
from ADP B-O
two NUM B-O
independent ADJ B-O
experiments NOUN B-O
( PUNCT B-O
C NOUN B-O
) PUNCT B-O
. PUNCT B-O
* PUNCT B-O
p NOUN B-O
< ADP B-O
0.05 NUM B-O
, PUNCT B-O
* PUNCT B-O
* PUNCT B-O
p NOUN B-O
< ADP B-O
0.01 NUM B-O
, PUNCT B-O
* PUNCT B-O
* PUNCT B-O
* PUNCT B-O
p NOUN B-O
< ADP B-O
0.001 NUM B-O
( PUNCT B-O
one NUM B-O
- NOUN B-O
way NOUN B-O
ANOVA NOUN B-O
with ADP B-O
Tukey PROPN B-O
’s PART B-O
post NOUN B-O
- NOUN B-O
test NOUN B-O
[ X B-O
A NOUN B-O
– PUNCT B-O
B NOUN B-O
] PUNCT B-O
or CCONJ B-O
Kruskal PROPN B-O
- NOUN B-O
Wallis PROPN B-O
test NOUN B-O
with ADP B-O
Dunn PROPN B-O
’s PART B-O
post NOUN B-O
- NOUN B-O
test NOUN B-O
[ X B-O
C NOUN B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O
ns NOUN B-O
, PUNCT B-O
not PART B-O
significant ADJ B-O
. PUNCT B-O

The DET B-O
neurotoxin NOUN B-O
6 NUM B-AC
- PUNCT B-AC
OHDA NOUN B-AC
is AUX B-O
selectively ADV B-O
transported VERB B-O
via ADP B-O
the DET B-O
dopamine NOUN B-LF
transporter NOUN I-LF
( PUNCT B-O
DAT PROPN B-AC
) PUNCT B-O
. PUNCT B-O
We PRON B-O
compared VERB B-O
toxicity NOUN B-O
of ADP B-O
6 NUM B-AC
- PUNCT B-AC
OHDA NOUN B-AC
in ADP B-O
purified ADJ B-O
and CCONJ B-O
unpurified ADJ B-O
N27 PROPN B-O
cells NOUN B-O
. PUNCT B-O

GFP PROPN B-AC
, PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT B-O

BD NOUN B-AC
, PUNCT B-O
birth NOUN B-LF
defect NOUN I-LF
. PUNCT B-O

We PRON B-O
compared VERB B-O
the DET B-O
tumor NOUN B-O
cells NOUN B-O
and CCONJ B-O
the DET B-O
patient NOUN B-O
's PART B-O
peripheral ADJ B-O
blood NOUN B-O
cells NOUN B-O
by ADP B-O
fluorescent ADJ B-O
in ADP B-O
situ NOUN B-O
hybridization NOUN B-O
using VERB B-O
X NOUN B-O
and CCONJ B-O
Y NOUN B-O
chromosome NOUN B-O
probes NOUN B-O
, PUNCT B-O
by ADP B-O
PCR NOUN B-O
for ADP B-O
the DET B-O
amelogenin NOUN B-O
gene NOUN B-O
X- NOUN B-O
and CCONJ B-O
Y NOUN B-O
- PUNCT B-O
specific ADJ B-O
alleles NOUN B-O
, PUNCT B-O
by ADP B-O
MassArray PROPN B-O
for ADP B-O
the DET B-O
ATM PROPN B-O
patient NOUN B-O
specific ADJ B-O
mutation NOUN B-O
and CCONJ B-O
for ADP B-O
several ADJ B-O
SNPs NOUN B-O
, PUNCT B-O
by ADP B-O
PCR NOUN B-O
for ADP B-O
polymorphic ADJ B-O
microsatellites NOUN B-O
, PUNCT B-O
and CCONJ B-O
by ADP B-O
human ADJ B-LF
leukocyte NOUN I-LF
antigen NOUN I-LF
( PUNCT B-O
HLA PROPN B-AC
) PUNCT B-O
typing NOUN B-O
. PUNCT B-O

The DET B-O
Area PROPN B-LF
Under ADP I-LF
the DET I-LF
Curve PROPN I-LF
( PUNCT B-O
AUC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
sensitivity NOUN B-O
, PUNCT B-O
specificity NOUN B-O
, PUNCT B-O
along ADP B-O
with ADP B-O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
( PUNCT B-O
PPV NOUN B-AC
) PUNCT B-O
and CCONJ B-O
negative ADJ B-O
predicting VERB B-O
value NOUN B-O
( PUNCT B-O
NPV NOUN B-AC
) PUNCT B-O
and CCONJ B-O
p NOUN B-O
value NOUN B-O
were AUX B-O
determined VERB B-O
. PUNCT B-O

For ADP B-O
Ontario PROPN B-O
residents NOUN B-O
with ADP B-O
diagnosed VERB B-O
OSA PROPN B-AC
, PUNCT B-O
funding NOUN B-O
is AUX B-O
provided VERB B-O
for ADP B-O
continuous ADJ B-LF
positive ADJ I-LF
airway NOUN I-LF
pressure NOUN I-LF
( PUNCT B-O
CPAP PROPN B-AC
) PUNCT B-O
devices NOUN B-O
, PUNCT B-O
and CCONJ B-O
this DET B-O
funding NOUN B-O
is AUX B-O
documented VERB B-O
in ADP B-O
the DET B-O
Assistive PROPN B-LF
Devices PROPN I-LF
Program PROPN I-LF
( PUNCT B-O
ADP PROPN B-AC
) PUNCT B-O
database NOUN B-O
from ADP B-O
2004 NUM B-O
onwards ADV B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

There PRON B-O
are VERB B-O
two NUM B-O
genome NOUN B-O
- PUNCT B-O
wide ADJ B-O
approaches NOUN B-O
to PART B-O
identify VERB B-O
novel ADJ B-O
imprinted VERB B-O
genes NOUN B-O
in ADP B-O
mammals NOUN B-O
: PUNCT B-O
quantification NOUN B-O
of ADP B-O
parent NOUN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
origin NOUN I-LF
differential ADJ I-LF
allelic ADJ I-LF
expression NOUN I-LF
( PUNCT B-O
pDAE PROPN B-AC
) PUNCT B-O
to PART B-O
identify VERB B-O
monoallelic ADJ B-O
expression NOUN B-O
directly ADV B-O
from ADP B-O
the DET B-O
transcripts NOUN B-O
, PUNCT B-O
or CCONJ B-O
identification NOUN B-O
of ADP B-O
parent NOUN B-LF
- PUNCT I-LF
of ADP I-LF
- PUNCT I-LF
origin NOUN I-LF
dependent ADJ I-LF
differentially ADV I-LF
methylated VERB I-LF
regions NOUN I-LF
( PUNCT B-O
pDMRs PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
genome NOUN B-O
. PUNCT B-O

Based VERB B-O
on ADP B-O
these DET B-O
data NOUN B-O
, PUNCT B-O
we PRON B-O
estimated VERB B-O
instantaneous ADJ B-LF
carboxylation NOUN I-LF
efficiency NOUN I-LF
( PUNCT B-O
PN NOUN B-AC
/ SYM B-AC
Ci NOUN B-AC
) PUNCT B-O
and CCONJ B-O
instantaneous ADJ B-LF
water NOUN I-LF
use NOUN I-LF
efficiency NOUN I-LF
( PUNCT B-O
WUE NOUN B-AC
, PUNCT B-O
( PUNCT B-O
μmol NOUN B-O
m-2 NOUN B-O
s-1)/(mmol NOUN B-O
H2O NOUN B-O
m-2 NOUN B-O
s-1 NOUN B-O
) PUNCT B-O
) PUNCT B-O
, PUNCT B-O
as ADP B-O
the DET B-O
ratio NOUN B-O
PN NOUN B-AC
/ SYM B-O
E NOUN B-O
[ PUNCT B-O
28 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
reduction NOUN B-O
in ADP B-O
the DET B-O
rate NOUN B-O
of ADP B-O
YLL PROPN B-AC
calculated VERB B-O
based VERB B-O
on ADP B-O
the DET B-O
age NOUN B-O
- PUNCT B-O
standardized VERB B-O
deaths NOUN B-O
shows VERB B-O
that SCONJ B-O
most ADJ B-O
causes NOUN B-O
of ADP B-O
death NOUN B-O
have AUX B-O
registered VERB B-O
a DET B-O
fall NOUN B-O
in ADP B-O
rate NOUN B-O
of ADP B-O
years NOUN B-LF
of ADP I-LF
life NOUN I-LF
lost VERB I-LF
from ADP B-O
1990 NUM B-O
to ADP B-O
2015 NUM B-O
. PUNCT B-O

Outcomes NOUN B-O
: PUNCT B-O
acid NOUN B-LF
- PUNCT I-LF
fast ADJ I-LF
bacilli NOUN I-LF
( PUNCT B-O
AFB PROPN B-AC
) PUNCT B-O
smear NOUN B-O
microscopy NOUN B-O
( PUNCT B-O
smear NOUN B-O
) PUNCT B-O
and CCONJ B-O
culture NOUN B-O
conversion NOUN B-O
, PUNCT B-O
adverse ADJ B-O
events NOUN B-O
, PUNCT B-O
and CCONJ B-O
WHO PROPN B-AC
- PUNCT B-O
defined VERB B-O
treatment NOUN B-O
outcomes NOUN B-O
, PUNCT B-O
including VERB B-O
cure NOUN B-O
, PUNCT B-O
treatment NOUN B-O
completion NOUN B-O
, PUNCT B-O
treatment NOUN B-O
failure NOUN B-O
, PUNCT B-O
loss NOUN B-O
to PART B-O
follow VERB B-O
- PUNCT B-O
up ADP B-O
, PUNCT B-O
not PART B-O
evaluated VERB B-O
, PUNCT B-O
and CCONJ B-O
death NOUN B-O
( PUNCT B-O
see VERB B-O
Table NOUN B-O
1 NUM B-O
for ADP B-O
definitions NOUN B-O
) PUNCT B-O
[ PUNCT B-O
7 NUM B-O
] PUNCT B-O
. PUNCT B-O

Acute ADJ B-O
cellular ADJ B-O
rejection NOUN B-O
and CCONJ B-O
interstitial ADJ B-LF
fibrosis NOUN I-LF
and CCONJ I-LF
tubular ADJ I-LF
atrophy NOUN I-LF
( PUNCT B-O
IF NOUN B-AC
/ SYM B-AC
TA NOUN B-AC
) PUNCT B-O
index NOUN B-O
were AUX B-O
graded VERB B-O
according VERB B-O
to ADP B-O
the DET B-O
Banff’13 PROPN B-O
criteria NOUN B-O
[ PUNCT B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

BMI PROPN B-AC
, PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
MHN PROPN B-AC
, PUNCT B-O
metabolically ADV B-LF
healthy ADJ I-LF
normal ADJ I-LF
weight NOUN I-LF
; PUNCT B-O
MHOO PROPN B-AC
, PUNCT B-O
metabolically ADV B-LF
healthy ADJ I-LF
overweight NOUN I-LF
or CCONJ I-LF
obesity NOUN I-LF
; PUNCT B-O
MUN PROPN B-AC
, PUNCT B-O
metabolically ADV B-LF
unhealthy ADJ I-LF
normal ADJ I-LF
weight NOUN I-LF
; PUNCT B-O
MUOO PROPN B-AC
, PUNCT B-O
metabolically ADV B-LF
unhealthy ADJ I-LF
overweight NOUN I-LF
or CCONJ I-LF
obesity NOUN I-LF
. PUNCT B-O

CC PROPN B-AC
, PUNCT B-O
corpus NOUN B-LF
callosum NOUN I-LF
; PUNCT B-O
DTI PROPN B-AC
, PUNCT B-O
diffusion NOUN B-LF
tensor NOUN I-LF
imaging NOUN I-LF
; PUNCT B-O
EC PROPN B-AC
, PUNCT B-O
external ADJ B-LF
capsule NOUN I-LF
; PUNCT B-O
EM PROPN B-AC
, PUNCT B-O
electron NOUN B-LF
microscopy NOUN I-LF
; PUNCT B-O
IL-4 NOUN B-AC
, PUNCT B-O
interleukin-4 NOUN B-LF
; PUNCT B-O
LSD PROPN B-AC
, PUNCT B-O
least ADJ B-LF
significant ADJ I-LF
difference NOUN I-LF
; PUNCT B-O
MCAO PROPN B-AC
, PUNCT B-O
middle ADJ B-LF
cerebral ADJ I-LF
artery NOUN I-LF
occlusion NOUN I-LF
. PUNCT B-O

Each DET B-O
record NOUN B-O
in ADP B-O
the DET B-O
census NOUN B-O
data NOUN B-O
had VERB B-O
information NOUN B-O
on ADP B-O
the DET B-O
census NOUN B-O
enumeration NOUN B-LF
area NOUN I-LF
( PUNCT B-O
EA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
smallest ADJ B-O
geographical ADJ B-O
unit NOUN B-O
, PUNCT B-O
with ADP B-O
an DET B-O
average ADJ B-O
population NOUN B-O
of ADP B-O
750 NUM B-O
. PUNCT B-O

MT NOUN B-O
, PUNCT B-O
microtubule NOUN B-O
; PUNCT B-O
PIV PROPN B-AC
, PUNCT B-O
particle NOUN B-LF
image NOUN I-LF
velocimetry NOUN I-LF
. PUNCT B-O

The DET B-O
following ADJ B-O
variables NOUN B-O
were AUX B-O
available ADJ B-O
for ADP B-O
analysis NOUN B-O
: PUNCT B-O
age NOUN B-O
, PUNCT B-O
sex NOUN B-O
, PUNCT B-O
ethnicity NOUN B-O
( PUNCT B-O
white ADJ B-O
, PUNCT B-O
black ADJ B-O
, PUNCT B-O
South ADJ B-O
Asian ADJ B-O
, PUNCT B-O
or CCONJ B-O
other ADJ B-O
) PUNCT B-O
, PUNCT B-O
smoking NOUN B-O
status NOUN B-O
( PUNCT B-O
current ADJ B-O
smoker NOUN B-O
, PUNCT B-O
previous ADJ B-O
smoker NOUN B-O
, PUNCT B-O
never ADV B-O
smoked VERB B-O
) PUNCT B-O
, PUNCT B-O
co NOUN B-O
- PUNCT B-O
morbidities NOUN B-O
( PUNCT B-O
diabetes NOUN B-LF
mellitus NOUN I-LF
[ PUNCT B-O
DM PROPN B-AC
] PUNCT B-O
, PUNCT B-O
ischaemic ADJ B-LF
heart NOUN I-LF
disease NOUN I-LF
[ PUNCT B-O
IHD PROPN B-AC
] PUNCT B-O
, PUNCT B-O
cerebrovascular ADJ B-O
disease NOUN B-O
, PUNCT B-O
peripheral ADJ B-LF
artery NOUN I-LF
disease NOUN I-LF
[ PUNCT B-O
PAD PROPN B-AC
] PUNCT B-O
, PUNCT B-O
chronic ADJ B-LF
obstructive ADJ I-LF
pulmonary ADJ I-LF
disease NOUN I-LF
[ PUNCT B-O
COPD PROPN B-AC
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
malignancy NOUN B-O
) PUNCT B-O
, PUNCT B-O
cause NOUN B-O
of ADP B-O
CKD PROPN B-AC
( PUNCT B-O
vascular ADJ B-O
, PUNCT B-O
diabetes NOUN B-O
, PUNCT B-O
glomerular ADJ B-O
, PUNCT B-O
tubulointerstitial ADJ B-O
, PUNCT B-O
cystic ADJ B-O
or CCONJ B-O
congenital ADJ B-O
, PUNCT B-O
or CCONJ B-O
other ADJ B-O
or CCONJ B-O
unknown ADJ B-O
) PUNCT B-O
, PUNCT B-O
mean ADJ B-LF
arterial ADJ I-LF
pressure NOUN I-LF
( PUNCT B-O
MAP PROPN B-AC
) PUNCT B-O
, PUNCT B-O
estimated VERB B-LF
glomerular ADJ I-LF
filtration NOUN I-LF
rate NOUN I-LF
( PUNCT B-O
eGFR PROPN B-AC
, PUNCT B-O
calculated VERB B-O
using VERB B-O
the DET B-O
4 NUM B-O
- PUNCT B-O
variable NOUN B-O
Modification PROPN B-O
of ADP B-O
Diet PROPN B-O
in ADP B-O
Renal PROPN B-O
Disease PROPN B-O
formula NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
urine NOUN B-O
albumin NOUN B-LF
- PUNCT I-LF
to ADP I-LF
- PUNCT I-LF
creatinine NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
ACR PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Following VERB B-O
this DET B-O
further ADJ B-O
simplification NOUN B-O
we PRON B-O
obtain VERB B-O
a DET B-O
new ADJ B-O
death NOUN B-O
model NOUN B-O
, PUNCT B-O
with ADP B-O
only ADV B-O
three NUM B-O
coefficients NOUN B-O
to PART B-O
estimate:(13)Finally VERB B-O
, PUNCT B-O
because SCONJ B-O
the DET B-O
values NOUN B-O
of ADP B-O
, PUNCT B-O
, PUNCT B-O
and CCONJ B-O
Ra NOUN B-O
come VERB B-O
with ADP B-O
confidence NOUN B-LF
intervals NOUN I-LF
( PUNCT B-O
CIs NOUN B-AC
) PUNCT B-O
, PUNCT B-O
we PRON B-O
need VERB B-O
to PART B-O
account VERB B-O
for ADP B-O
this DET B-O
uncertainty NOUN B-O
when SCONJ B-O
computing VERB B-O
CFRs NOUN B-AC
. PUNCT B-O
For ADP B-O
each DET B-O
age NOUN B-O
group NOUN B-O
a DET B-O
, PUNCT B-O
we PRON B-O
proceed VERB B-O
as ADP B-O
follows VERB B-O
. PUNCT B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
We PRON B-O
generate VERB B-O
K NOUN B-O
= SYM B-O
1,000 NUM B-O
sample NOUN B-O
datasets NOUN B-O
, PUNCT B-O
where SCONJ B-O
and CCONJ B-O
are AUX B-O
sampled VERB B-O
from ADP B-O
a DET B-O
normal ADJ B-O
distribution NOUN B-O
with ADP B-O
the DET B-O
same ADJ B-O
mean NOUN B-O
and CCONJ B-O
95 NUM B-O
% NOUN B-O
CI NOUN B-AC
as ADP B-O
in ADP B-O
Tables NOUN B-O
S2 NUM B-O
and CCONJ B-O
S3 NOUN B-O
of ADP B-O
Text NOUN B-O
S1 NOUN B-O
, PUNCT B-O
whereas SCONJ B-O
values NOUN B-O
are AUX B-O
obtained VERB B-O
by ADP B-O
running VERB B-O
our PRON B-O
model NOUN B-O
parameters NOUN B-O
sampled VERB B-O
from ADP B-O
the DET B-O
joint ADJ B-O
posterior ADJ B-O
distribution NOUN B-O
of ADP B-O
our PRON B-O
MCMC PROPN B-AC
analysis NOUN B-O
. PUNCT B-O
( PUNCT B-O
2 X B-O
) PUNCT B-O
We PRON B-O
fit VERB B-O
the DET B-O
death NOUN B-O
model NOUN B-O
for ADP B-O
each DET B-O
replicate NOUN B-O
k NOUN B-O
by ADP B-O
maximum NOUN B-O
likelihood NOUN B-O
using VERB B-O
the DET B-O
function NOUN B-O
glm.nb NOUN B-O
of ADP B-O
R NOUN B-O
2.15.1 NUM B-O
[ PUNCT B-O
35 NUM B-O
] PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
screened VERB B-O
for ADP B-O
new ADJ B-O
sporulation NOUN B-O
genes NOUN B-O
using VERB B-O
a DET B-O
transposon NOUN B-LF
- NOUN I-LF
sequencing VERB I-LF
( PUNCT B-O
Tn PROPN B-AC
- NOUN B-AC
seq NOUN B-AC
) PUNCT B-O
approach NOUN B-O
[ PUNCT B-O
28 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
white ADJ B-O
asterisks NOUN B-O
represent VERB B-O
the DET B-O
CF PROPN B-AC
located VERB B-O
at ADP B-O
1 NUM B-O
and CCONJ B-O
21 NUM B-O
kHz NOUN B-O
, PUNCT B-O
respectively ADV B-O
. PUNCT B-O
( PUNCT B-O
B NOUN B-O
) PUNCT B-O
Figure NOUN B-O
shows VERB B-O
the DET B-O
color NOUN B-O
- PUNCT B-O
coded VERB B-O
locations NOUN B-O
of ADP B-O
the DET B-O
recording VERB B-O
sites NOUN B-O
within ADP B-O
the DET B-O
schematic ADJ B-O
representation NOUN B-O
of ADP B-O
the DET B-O
parcellation NOUN B-O
of ADP B-O
the DET B-O
auditory ADJ B-O
cortex NOUN B-O
[ PUNCT B-O
( PUNCT B-O
AAF PROPN B-O
( PUNCT B-O
anterior ADJ B-O
auditory ADJ B-O
field NOUN B-O
) PUNCT B-O
, PUNCT B-O
AI PROPN B-AC
( PUNCT B-O
primary ADJ B-LF
auditory ADJ I-LF
cortex NOUN I-LF
) PUNCT B-O
, PUNCT B-O
D PROPN B-O
( PUNCT B-O
dorsal ADJ B-O
field NOUN B-O
) PUNCT B-O
, PUNCT B-O
DP PROPN B-O
( PUNCT B-O
dorsoposterior ADJ B-O
field NOUN B-O
) PUNCT B-O
, PUNCT B-O
V NOUN B-O
( PUNCT B-O
ventral ADJ B-O
field NOUN B-O
) PUNCT B-O
, PUNCT B-O
VP PROPN B-O
( PUNCT B-O
ventroposterior ADJ B-O
field NOUN B-O
) PUNCT B-O
] PUNCT B-O
. PUNCT B-O

Essential ADJ B-O
data NOUN B-O
are AUX B-O
available ADJ B-O
on ADP B-O
https://git.io/JTg1l X B-O
. PUNCT B-O
a.u NOUN B-O
. PUNCT B-O
, PUNCT B-O
arbitrary ADJ B-O
units NOUN B-O
; PUNCT B-O
GD PROPN B-AC
, PUNCT B-O
geodesic ADJ B-LF
distance NOUN I-LF
; PUNCT B-O
MPC NOUN B-AC
, PUNCT B-O
microstructure NOUN B-LF
profile NOUN I-LF
covariance NOUN I-LF
; PUNCT B-O
TS PROPN B-O
, PUNCT B-O
tractography NOUN B-O
strength NOUN B-O
. PUNCT B-O

Plasma NOUN B-O
levels NOUN B-O
of ADP B-O
NAD+ NOUN B-O
and CCONJ B-O
its PRON B-O
metabolites NOUN B-O
[ X B-O
NADP+ NOUN B-O
, PUNCT B-O
cyclic ADJ B-LF
ADP NOUN I-LF
ribose NOUN I-LF
( PUNCT B-O
cADPR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
nicotinamide NOUN B-LF
( PUNCT B-O
NAM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
N NOUN B-LF
- NOUN I-LF
methylnicotinamide NOUN I-LF
( PUNCT B-O
MeNAM NOUN B-AC
) PUNCT B-O
] PUNCT B-O
were AUX B-O
measured VERB B-O
by ADP B-O
liquid NOUN B-O
chromatography NOUN B-O
coupled VERB B-O
to ADP B-O
tandem ADJ B-O
mass NOUN B-O
spectrometry NOUN B-O
( PUNCT B-O
LC NOUN B-O
/ SYM B-O
MS PROPN B-O
/ SYM B-O
MS PROPN B-O
) PUNCT B-O
, PUNCT B-O
as SCONJ B-O
previously ADV B-O
described VERB B-O
[ X B-O
25 NUM B-O
] PUNCT B-O
. PUNCT B-O

As SCONJ B-O
ART PROPN B-AC
coverage NOUN B-O
increases NOUN B-O
from ADP B-O
10 NUM B-O
% PUNCT B-O
to ADP B-O
97 NUM B-O
% PUNCT B-O
of ADP B-O
eligible ADJ B-O
employees NOUN B-O
, PUNCT B-O
increases NOUN B-O
in ADP B-O
survival NOUN B-O
and CCONJ B-O
retention NOUN B-O
of ADP B-O
HIV PROPN B-O
- PUNCT B-O
positive ADJ B-O
employees NOUN B-O
and CCONJ B-O
associated VERB B-O
reductions NOUN B-O
in ADP B-O
absenteeism NOUN B-O
and CCONJ B-O
benefit NOUN B-O
payments NOUN B-O
lead VERB B-O
to ADP B-O
cost NOUN B-O
savings NOUN B-O
compared VERB B-O
to ADP B-O
a DET B-O
scenario NOUN B-O
of ADP B-O
no DET B-O
treatment NOUN B-O
provision NOUN B-O
, PUNCT B-O
with ADP B-O
the DET B-O
annual ADJ B-O
cost NOUN B-O
of ADP B-O
HIV PROPN B-O
to ADP B-O
the DET B-O
company NOUN B-O
decreasing VERB B-O
by ADP B-O
5 NUM B-O
% PUNCT B-O
( PUNCT B-O
90 NUM B-O
% PUNCT B-O
credibility NOUN B-LF
interval NOUN I-LF
[ X B-O
CrI NOUN B-AC
] X B-O
2%–8 NUM B-O
% PUNCT B-O
) PUNCT B-O
and CCONJ B-O
the DET B-O
mean ADJ B-O
cost NOUN B-O
per ADP B-O
HIV PROPN B-O
- PUNCT B-O
positive ADJ B-O
employee NOUN B-O
decreasing VERB B-O
by ADP B-O
14 NUM B-O
% PUNCT B-O
( PUNCT B-O
90 NUM B-O
% PUNCT B-O
CrI NOUN B-AC
7%–19 NUM B-O
% PUNCT B-O
) PUNCT B-O
by ADP B-O
2022 NUM B-O
. PUNCT B-O

We PRON B-O
used VERB B-O
data NOUN B-O
from ADP B-O
14,633 NUM B-O
singleton ADJ B-O
live ADJ B-O
birth NOUN B-O
pregnancies NOUN B-O
from ADP B-O
women NOUN B-O
participating VERB B-O
in ADP B-O
13 NUM B-O
studies NOUN B-O
conducted VERB B-O
from ADP B-O
1996 NUM B-O
to ADP B-O
2015 NUM B-O
in ADP B-O
8 NUM B-O
African ADJ B-O
countries NOUN B-O
and CCONJ B-O
the DET B-O
Western PROPN B-O
Pacific PROPN B-O
( PUNCT B-O
PNG PROPN B-AC
) PUNCT B-O
as ADP B-O
part NOUN B-O
of ADP B-O
the DET B-O
Maternal PROPN B-LF
Malaria PROPN I-LF
and CCONJ I-LF
Malnutrition PROPN I-LF
( PUNCT B-O
M3 PROPN B-AC
) PUNCT B-O
initiative NOUN B-O
[ X B-O
9,11,13–24 NUM B-O
] PUNCT B-O
. PUNCT B-O

Participants NOUN B-O
were AUX B-O
randomly ADV B-O
allocated VERB B-O
in ADP B-O
a DET B-O
1∶1 NUM B-O
ratio NOUN B-O
to ADP B-O
induction NOUN B-LF
of ADP I-LF
labor NOUN I-LF
( PUNCT B-O
IoL PROPN B-AC
) PUNCT B-O
or CCONJ B-O
expectant ADJ B-LF
management NOUN I-LF
( PUNCT B-O
EM PROPN B-AC
) PUNCT B-O
using VERB B-O
block NOUN B-O
randomization NOUN B-O
. PUNCT B-O

BMI PROPN B-AC
, PUNCT B-O
Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
BW PROPN B-AC
, PUNCT B-O
Birthweight NOUN B-LF
. PUNCT B-O

Expression NOUN B-O
of ADP B-O
steroid NOUN B-LF
5α NOUN I-LF
- NOUN I-LF
reductase NOUN I-LF
type NOUN I-LF
2 NUM I-LF
( PUNCT B-O
SRD5A2 NOUN B-AC
) PUNCT B-O
was AUX B-O
only ADV B-O
consistently ADV B-O
detectable ADJ B-O
in ADP B-O
the DET B-O
genital ADJ B-O
tubercle NOUN B-O
. PUNCT B-O

Our PRON B-O
primary ADJ B-O
MR NOUN B-AC
analysis NOUN B-O
method NOUN B-O
was AUX B-O
inverse ADJ B-LF
variance NOUN I-LF
weighted VERB I-LF
( PUNCT B-O
IVW PROPN B-AC
) PUNCT B-O
regression NOUN B-O
where SCONJ B-O
at ADV B-O
least ADV B-O
two NUM B-O
exposure NOUN B-O
SNPs NOUN B-AC
were AUX B-O
available ADJ B-O
for ADP B-O
analysis NOUN B-O
. PUNCT B-O

CKIP-1 PROPN B-O
, PUNCT B-O
casein NOUN B-O
kinase NOUN B-O
interacting VERB B-O
protein NOUN B-O
1 NUM B-O
; PUNCT B-O
H2B PROPN B-AC
, PUNCT B-O
histone NOUN B-LF
2B NUM I-LF
; PUNCT B-O
HH PROPN B-AC
, PUNCT B-O
Hamburger PROPN B-LF
- PUNCT I-LF
Hamilton PROPN I-LF
stage NOUN I-LF
; PUNCT B-O
pSmad1/5/8 NUM B-AC
, PUNCT B-O
phospho NOUN B-O
- PUNCT B-O
Smads NOUN B-O
1/5/8 NUM B-O
; PUNCT B-O
RFP PROPN B-AC
, PUNCT B-O
red ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
. PUNCT B-O

AMPA PROPN B-AC
, PUNCT B-O
α NOUN B-LF
- PUNCT I-LF
amino-3 NOUN I-LF
- PUNCT I-LF
hydroxy-5 NOUN I-LF
- PUNCT I-LF
methyl-4 NOUN I-LF
- PUNCT I-LF
isoxazolepropionic NOUN I-LF
acid NOUN I-LF
; PUNCT B-O
BF PROPN B-O
, PUNCT B-O
bright ADJ B-O
field NOUN B-O
; PUNCT B-O
CCK8 PROPN B-AC
, PUNCT B-O
Cell PROPN B-LF
Counting PROPN I-LF
Kit-8 PROPN I-LF
; PUNCT B-O
CGC PROPN B-AC
, PUNCT B-O
cerebellar NOUN B-LF
granule NOUN I-LF
cell NOUN I-LF
; PUNCT B-O
cKO PROPN B-AC
, PUNCT B-O
Mettl3 NOUN B-LF
conditional ADJ I-LF
knockout NOUN I-LF
; PUNCT B-O
CREB PROPN B-AC
, PUNCT B-O
cAMP NOUN B-LF
responsive ADJ I-LF
element NOUN I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT B-O
Ctrl PROPN B-AC
, PUNCT B-O
control NOUN B-LF
; PUNCT B-O
DIV PROPN B-O
, PUNCT B-O
days NOUN B-O
in ADP B-O
vitro ADJ B-O
; PUNCT B-O
Grin1001 PROPN B-O
, PUNCT B-O
C1 PROPN B-O
region NOUN B-O
excluded VERB B-O
variant NOUN B-O
of ADP B-O
Grin1 PROPN B-O
; PUNCT B-O
Grin1011 PROPN B-O
, PUNCT B-O
C1 PROPN B-O
region NOUN B-O
included VERB B-O
variant NOUN B-O
of ADP B-O
Grin1 PROPN B-O
; PUNCT B-O
IGV PROPN B-AC
, PUNCT B-O
integrative ADJ B-LF
genomics NOUN I-LF
viewer NOUN I-LF
; PUNCT B-O
METTL3 PROPN B-AC
, PUNCT B-O
methyltransferase NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
3 NUM I-LF
; PUNCT B-O
m6A PROPN B-AC
, PUNCT B-O
N6 NOUN B-LF
- PUNCT I-LF
methyladenosine NOUN I-LF
; PUNCT B-O
NMDA PROPN B-AC
, PUNCT B-O
N NOUN B-LF
- PUNCT I-LF
methyl NOUN I-LF
- PUNCT I-LF
D NOUN I-LF
- PUNCT I-LF
aspartic NOUN I-LF
acid NOUN I-LF
; PUNCT B-O
PKMT PROPN B-AC
, PUNCT B-O
Lysine NOUN B-LF
methyltransferase NOUN I-LF
; PUNCT B-O
PPAR PROPN B-AC
, PUNCT B-O
peroxisome NOUN B-LF
proliferator NOUN I-LF
- PUNCT I-LF
activated VERB I-LF
receptor NOUN I-LF
; PUNCT B-O
PSI PROPN B-AC
, PUNCT B-O
percent NOUN B-LF
spliced VERB I-LF
in ADP I-LF
index NOUN I-LF
; PUNCT B-O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT B-O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT B-O
SEM NOUN B-AC
, PUNCT B-O
standard ADJ B-LF
error NOUN I-LF
of ADP I-LF
the DET I-LF
mean NOUN I-LF
. PUNCT B-O

Thus ADV B-O
, PUNCT B-O
we PRON B-O
determined VERB B-O
glycemic ADJ B-O
control NOUN B-O
of ADP B-O
p8 NOUN B-O
in ADP B-O
mice NOUN B-O
fed VERB B-O
with ADP B-O
standard ADJ B-O
( PUNCT B-O
SD PROPN B-AC
) PUNCT B-O
and CCONJ B-O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
( PUNCT B-O
HFD PROPN B-AC
) PUNCT B-O
. PUNCT B-O

PRCP NOUN B-AC
activity NOUN B-O
was AUX B-O
determined VERB B-O
by ADP B-O
measuring VERB B-O
the DET B-O
hydrolysis NOUN B-O
of ADP B-O
N NOUN B-LF
- NOUN I-LF
benzyloxycarbonyl NOUN I-LF
- NOUN I-LF
Pro PROPN I-LF
- NOUN I-LF
Phe PROPN I-LF
( PUNCT B-O
Z NOUN B-AC
- NOUN B-AC
Pro PROPN B-AC
- NOUN B-AC
Phe PROPN B-AC
; PUNCT B-O
Bachem PROPN B-O
, PUNCT B-O
Bubendorf PROPN B-O
, PUNCT B-O
Switzerland PROPN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
identification NOUN B-O
of ADP B-O
all DET B-O
comorbidities NOUN B-O
, PUNCT B-O
except SCONJ B-O
traumatic ADJ B-O
brain NOUN B-O
injury NOUN B-O
, PUNCT B-O
relied VERB B-O
on ADP B-O
algorithms NOUN B-O
developed VERB B-O
by ADP B-O
SNDS PROPN B-AC
experts NOUN B-O
in ADP B-O
collaboration NOUN B-O
with ADP B-O
the DET B-O
institution NOUN B-O
in ADP B-O
charge NOUN B-O
of ADP B-O
the DET B-O
SNDS PROPN B-AC
, PUNCT B-O
the DET B-O
Caisse PROPN B-LF
Nationale PROPN I-LF
d’Assurance PROPN I-LF
Maladie PROPN I-LF
des PROPN I-LF
Travailleurs PROPN I-LF
Salariés PROPN I-LF
( PUNCT B-O
CNAMTS PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
36 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
trials NOUN B-O
included VERB B-O
are AUX B-O
as SCONJ B-O
follows VERB B-O
: PUNCT B-O
9 X B-O
= PUNCT B-O
Australasian PROPN B-LF
Collaborative PROPN I-LF
Trial PROPN I-LF
of ADP I-LF
Magnesium PROPN I-LF
Sulphate PROPN I-LF
( PUNCT B-O
ACTOMgSO4 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
10 X B-O
= PUNCT B-O
PREterm NOUN B-LF
brain NOUN I-LF
protection NOUN I-LF
by ADP I-LF
MAGnesium PROPN I-LF
sulphate NOUN I-LF
( PUNCT B-O
PREMAG PROPN B-AC
) PUNCT B-O
, PUNCT B-O
11 X B-O
= PUNCT B-O
Magnesium PROPN B-LF
and CCONJ I-LF
Neurologic PROPN I-LF
Endpoints PROPN I-LF
Trial PROPN I-LF
( PUNCT B-O
MAGNET PROPN B-AC
) PUNCT B-O
, PUNCT B-O
12 X B-O
= PUNCT B-O
MAGnesium PROPN B-LF
sulphate NOUN I-LF
for ADP I-LF
Prevention PROPN I-LF
of ADP I-LF
Eclampsia PROPN I-LF
( PUNCT B-O
MAGPIE PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
13 X B-O
= PUNCT B-O
Beneficial PROPN B-LF
Effects PROPN I-LF
of ADP I-LF
Antenatal PROPN I-LF
Magnesium PROPN I-LF
Sulfate PROPN I-LF
( PUNCT B-O
BEAM PROPN B-AC
) PUNCT B-O
. PUNCT B-O

( PUNCT B-O
Cr NOUN B-O
= PUNCT B-O
creatine NOUN B-O
; PUNCT B-O
PCr NOUN B-O
= PUNCT B-O
phosphocreatine NOUN B-O
; PUNCT B-O
GSH NOUN B-AC
= PUNCT B-O
glutathione NOUN B-LF
; PUNCT B-O
GABA NOUN B-AC
= PUNCT B-O
γ NOUN B-LF
- NOUN I-LF
amino NOUN I-LF
butyric NOUN I-LF
acid NOUN I-LF
; PUNCT B-O
NAA PROPN B-O
= PUNCT B-O
N NOUN B-O
- NOUN B-O
acetylaspartic NOUN B-O
acid NOUN B-O
) PUNCT B-O
. PUNCT B-O

CP NOUN B-AC
: PUNCT B-O
Chronic ADJ B-LF
Pain NOUN I-LF
phenotype NOUN I-LF

Abbreviations NOUN B-O
: PUNCT B-O
ANC PROPN B-AC
, PUNCT B-O
antenatal ADJ B-LF
care NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
, PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
LOS PROPN B-AC
, PUNCT B-O
length NOUN B-LF
of ADP I-LF
stay NOUN I-LF
; PUNCT B-O
OR NOUN B-AC
, PUNCT B-O
odds NOUN B-LF
ratio NOUN I-LF
; PUNCT B-O
ref NOUN B-O
, PUNCT B-O
reference NOUN B-O
; PUNCT B-O
SBA PROPN B-AC
, PUNCT B-O
skilled ADJ B-LF
birth NOUN I-LF
attendant NOUN I-LF
. PUNCT B-O

Within ADP B-O
ENSANUT PROPN B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
the DET B-O
semiquantitative ADJ B-LF
food NOUN I-LF
frequency NOUN I-LF
questionnaire NOUN I-LF
( PUNCT B-O
SFFQ PROPN B-AC
) PUNCT B-O
to PART B-O
estimate VERB B-O
baseline ADJ B-O
intake NOUN B-O
of ADP B-O
beverages NOUN B-O
and CCONJ B-O
snacks NOUN B-O
. PUNCT B-O

India PROPN B-O
's PART B-O
Total PROPN B-LF
Sanitation PROPN I-LF
Campaign PROPN I-LF
( PUNCT B-O
TSC PROPN B-AC
) PUNCT B-O
is AUX B-O
one NUM B-O
such ADJ B-O
program NOUN B-O
that PRON B-O
seeks VERB B-O
to PART B-O
end VERB B-O
the DET B-O
practice NOUN B-O
of ADP B-O
open ADJ B-O
defecation NOUN B-O
by ADP B-O
changing VERB B-O
social ADJ B-O
norms NOUN B-O
and CCONJ B-O
behaviors NOUN B-O
, PUNCT B-O
and CCONJ B-O
providing VERB B-O
technical ADJ B-O
support NOUN B-O
and CCONJ B-O
financial ADJ B-O
subsidies NOUN B-O
. PUNCT B-O

OS PROPN B-AC
: PUNCT B-O
outer ADJ B-O
segment NOUN B-O
; PUNCT B-O
ONL PROPN B-AC
: PUNCT B-O
outer ADJ B-LF
nuclear ADJ I-LF
layer NOUN I-LF
; PUNCT B-O
INL PROPN B-AC
: PUNCT B-O
inner ADJ B-LF
nuclear ADJ I-LF
layer NOUN I-LF
; PUNCT B-O
GCL PROPN B-AC
: PUNCT B-O
ganglion NOUN B-LF
cell NOUN I-LF
layer NOUN I-LF
. PUNCT B-O

With SCONJ B-O
HIV PROPN B-O
prevalence NOUN B-O
estimated VERB B-O
at ADP B-O
7.3 NUM B-O
% NOUN B-O
among ADP B-O
the DET B-O
general ADJ B-O
population NOUN B-O
[ PUNCT B-O
7 NUM B-O
] PUNCT B-O
, PUNCT B-O
Uganda PROPN B-O
is AUX B-O
one NUM B-O
of ADP B-O
14 NUM B-O
priority NOUN B-O
countries NOUN B-O
identified VERB B-O
for ADP B-O
high ADJ B-O
- PUNCT B-O
level NOUN B-O
SMC PROPN B-AC
scale NOUN B-O
- PUNCT B-O
up NOUN B-O
by ADP B-O
the DET B-O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WHO PROPN B-AC
) PUNCT B-O
and CCONJ B-O
the DET B-O
Joint PROPN B-LF
United PROPN I-LF
Nations PROPN I-LF
Programme PROPN I-LF
on ADP I-LF
HIV PROPN I-LF
/ SYM I-LF
AIDS PROPN I-LF
( PUNCT B-O
UNAIDS PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
8 NUM B-O
] PUNCT B-O
. PUNCT B-O

To PART B-O
calculate VERB B-O
QALYs NOUN B-AC
, PUNCT B-O
utilities NOUN B-O
are AUX B-O
necessary ADJ B-O
and CCONJ B-O
these PRON B-O
can AUX B-O
be AUX B-O
derived VERB B-O
from ADP B-O
preference NOUN B-LF
- PUNCT I-LF
based VERB I-LF
measures NOUN I-LF
( PUNCT B-O
PBMs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
the DET B-O
EuroQol PROPN B-LF
five NUM I-LF
- PUNCT I-LF
dimensional ADJ I-LF
questionnaire NOUN I-LF
( PUNCT B-O
EQ-5D PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
WHO PROPN B-AC
Study PROPN B-LF
on ADP I-LF
Global PROPN I-LF
Ageing PROPN I-LF
and CCONJ I-LF
Adult PROPN I-LF
Health PROPN I-LF
( PUNCT B-O
SAGE PROPN B-AC
) PUNCT B-O
wave NOUN B-O
2 NUM B-O
for ADP B-O
Ghana PROPN B-O
was AUX B-O
conducted VERB B-O
in ADP B-O
2014–2015 NUM B-O
, PUNCT B-O
as ADP B-O
part NOUN B-O
of ADP B-O
the DET B-O
multi ADJ B-O
- ADJ B-O
country ADJ B-O
study NOUN B-O
on ADP B-O
aging NOUN B-O
. PUNCT B-O

FFPE PROPN B-AC
, PUNCT B-O
formalin NOUN B-LF
- PUNCT I-LF
fixed VERB I-LF
paraffin NOUN I-LF
- PUNCT I-LF
embedded VERB I-LF
; PUNCT B-O
HPV PROPN B-AC
, PUNCT B-O
human ADJ B-LF
papillomavirus NOUN I-LF
. PUNCT B-O

The DET B-O
results NOUN B-O
of ADP B-O
the DET B-O
examination NOUN B-O
are AUX B-O
sent VERB B-O
to ADP B-O
US PROPN B-O
state NOUN B-O
and CCONJ B-O
local ADJ B-O
health NOUN B-O
departments NOUN B-O
via ADP B-O
CDC PROPN B-AC
’s PART B-O
Electronic PROPN B-LF
Disease PROPN I-LF
Notification PROPN I-LF
system NOUN I-LF
( PUNCT B-O
EDN PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
4 NUM B-O
] PUNCT B-O
. PUNCT B-O

Depressive ADJ B-O
symptoms NOUN B-O
were AUX B-O
measured VERB B-O
by ADP B-O
10 NUM B-LF
- PUNCT I-LF
item NOUN I-LF
Center PROPN I-LF
for ADP I-LF
Epidemiologic PROPN I-LF
Studies PROPN I-LF
( PUNCT B-O
CES PROPN B-AC
- PUNCT B-AC
D PROPN B-AC
10 NUM B-AC
) PUNCT B-O
. PUNCT B-O

Similarly ADV B-O
, PUNCT B-O
degradation NOUN B-O
of ADP B-O
REV NOUN B-O
- PUNCT B-O
ERBα NOUN B-O
by ADP B-O
Homologous PROPN B-LF
to ADP I-LF
the DET I-LF
E6 PROPN I-LF
- PUNCT I-LF
AP PROPN I-LF
Carboxyl PROPN I-LF
Terminus PROPN I-LF
( PUNCT B-O
HECT)-(ARF PROPN B-AC
- PUNCT B-O
BP1 PROPN B-O
) PUNCT B-O
and CCONJ B-O
Really ADV B-LF
Interesting ADJ I-LF
New PROPN I-LF
Gene PROPN I-LF
( PUNCT B-O
RING)-class PROPN B-AC
E3 NOUN B-O
ligases NOUN B-O
( PUNCT B-O
PAM PROPN B-O
) PUNCT B-O
is AUX B-O
induced VERB B-O
by ADP B-O
phosphorylation NOUN B-O
by ADP B-O
glycogen NOUN B-LF
synthase NOUN I-LF
kinase NOUN I-LF
3β NOUN I-LF
( PUNCT B-O
GSK3β PROPN B-AC
) PUNCT B-O
[ X B-O
5,6 NUM B-O
] PUNCT B-O
. PUNCT B-O

Ceramides NOUN B-O
in ADP B-O
the DET B-O
epidermis NOUN B-O
are AUX B-O
synthesized VERB B-O
by ADP B-O
several ADJ B-O
enzymes NOUN B-O
such ADJ B-O
as ADP B-O
serine NOUN B-LF
palmitoyltransferase NOUN I-LF
( PUNCT B-O
SPT PROPN B-AC
) PUNCT B-O
, PUNCT B-O
ceramide NOUN B-LF
synthase NOUN I-LF
( PUNCT B-O
CerS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
glucosylceramide NOUN B-LF
synthase NOUN I-LF
( PUNCT B-O
GCS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
β NOUN B-O
- NOUN B-O
glucocerebrosidese NOUN B-O
( PUNCT B-O
GBA PROPN B-AC
) PUNCT B-O
, PUNCT B-O
sphingomyelin NOUN B-LF
synthase NOUN I-LF
( PUNCT B-O
SMS PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
acid NOUN B-LF
sphingomyelinase NOUN I-LF
( PUNCT B-O
ASM PROPN B-AC
) PUNCT B-O
. PUNCT B-O
SPT PROPN B-AC
and CCONJ B-O
CerS PROPN B-AC
are AUX B-O
involved VERB B-O
in ADP B-O
the DET B-O
de X B-O
novo X B-O
synthesis NOUN B-O
of ADP B-O
ceramides NOUN B-O
. PUNCT B-O

In ADP B-O
addition NOUN B-O
, PUNCT B-O
its PRON B-O
activity NOUN B-O
can AUX B-O
also ADV B-O
be AUX B-O
negatively ADV B-O
regulated VERB B-O
by ADP B-O
type NOUN B-O
I NUM B-O
HDACs PROPN B-AC
, PUNCT B-O
protein NOUN B-LF
inhibitor NOUN I-LF
of ADP I-LF
activated ADJ I-LF
STAT3 PROPN I-LF
( PUNCT B-O
PIAS3 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
suppressor NOUN B-O
of ADP B-O
cytokine NOUN B-O
signaling NOUN B-O
3 NUM B-O
( PUNCT B-O
SOCS3 PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
38–42 NUM B-O
] PUNCT B-O
. PUNCT B-O

For ADP B-O
statistical ADJ B-O
analyses NOUN B-O
, PUNCT B-O
data NOUN B-O
were AUX B-O
modelled VERB B-O
using VERB B-O
a DET B-O
linear ADJ B-LF
model NOUN I-LF
( PUNCT B-O
LM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
a DET B-O
linear ADJ B-LF
mixed ADJ I-LF
model NOUN I-LF
( PUNCT B-O
LMM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
or CCONJ B-O
a DET B-O
general ADJ B-LF
linear ADJ I-LF
mixed ADJ I-LF
model NOUN I-LF
( PUNCT B-O
GLMM PROPN B-AC
) PUNCT B-O
with ADP B-O
diet NOUN B-O
as ADP B-O
fixed ADJ B-O
and CCONJ B-O
independent ADJ B-O
experiment NOUN B-O
as ADP B-O
random ADJ B-O
effect NOUN B-O
followed VERB B-O
by ADP B-O
a DET B-O
Wald PROPN B-O
chi NOUN B-O
- PUNCT B-O
squared ADJ B-O
test NOUN B-O
. PUNCT B-O

Instruments NOUN B-O
used VERB B-O
included VERB B-O
the DET B-O
Bayley PROPN B-LF
Scale PROPN I-LF
of ADP I-LF
Infant PROPN I-LF
Development- PROPN I-LF
second ADJ I-LF
edition NOUN I-LF
( PUNCT B-O
BSID PROPN B-AC
- PUNCT B-AC
II PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
31 NUM B-O
] PUNCT B-O
, PUNCT B-O
Mullen PROPN B-LF
Scales PROPN I-LF
for ADP I-LF
Early PROPN I-LF
Learning PROPN I-LF
( PUNCT B-O
MSEL PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
32 NUM B-O
] PUNCT B-O
, PUNCT B-O
or CCONJ B-O
a DET B-O
cognitive ADJ B-O
test NOUN B-O
such ADJ B-O
as ADP B-O
the DET B-O
Stanford PROPN B-LF
- PUNCT I-LF
Binet PROPN I-LF
Fourth PROPN I-LF
Edition PROPN I-LF
( PUNCT B-O
SB-4 PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
33 NUM B-O
] PUNCT B-O
, PUNCT B-O
Wechsler PROPN B-LF
Preschool PROPN I-LF
and CCONJ I-LF
Primary PROPN I-LF
Scale PROPN I-LF
for ADP I-LF
Intelligence PROPN I-LF
– PUNCT I-LF
Third PROPN I-LF
Edition PROPN I-LF
( PUNCT B-O
WPPSI PROPN B-AC
- PUNCT B-AC
III PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
34 NUM B-O
] PUNCT B-O
, PUNCT B-O
Wechsler PROPN B-LF
Intelligence PROPN I-LF
Scale PROPN I-LF
for ADP I-LF
Children PROPN I-LF
– PUNCT I-LF
Revised VERB I-LF
( PUNCT B-O
WISC PROPN B-AC
- PUNCT B-AC
R PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
35 NUM B-O
] PUNCT B-O
, PUNCT B-O
or CCONJ B-O
Kaufman PROPN B-LF
Brief PROPN I-LF
Intelligence PROPN I-LF
Test PROPN I-LF
( PUNCT B-O
K PROPN B-AC
- PUNCT B-AC
BIT PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
36 NUM B-O
] PUNCT B-O
. PUNCT B-O

The DET B-O
solubility NOUN B-LF
product NOUN I-LF
constant NOUN B-O
, PUNCT B-O
Ksp PROPN B-AC
, PUNCT B-O
is AUX B-O
the DET B-O
equilibrium NOUN B-O
constant NOUN B-O
used VERB B-O
to PART B-O
describe VERB B-O
the DET B-O
dissolution NOUN B-O
of ADP B-O
a DET B-O
solid ADJ B-O
in ADP B-O
a DET B-O
solution NOUN B-O
. PUNCT B-O

CES PROPN B-AC
, PUNCT B-O
chromatin NOUN B-LF
entry NOUN I-LF
site NOUN I-LF
; PUNCT B-O
MSL PROPN B-AC
, PUNCT B-O
male NOUN B-LF
- PUNCT I-LF
specific ADJ I-LF
lethal NOUN I-LF
. PUNCT B-O

AD PROPN B-AC
, PUNCT B-O
adult NOUN B-LF
day NOUN I-LF
; PUNCT B-O
CHC PROPN B-AC
, PUNCT B-O
cuticular ADJ B-LF
hydrocarbon NOUN I-LF
; PUNCT B-O
RNAi NOUN B-AC
, PUNCT B-O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT B-O

Women NOUN B-O
were AUX B-O
classified VERB B-O
into ADP B-O
three NUM B-O
groups NOUN B-O
according VERB B-O
to ADP B-O
FPG PROPN B-AC
level NOUN B-O
and CCONJ B-O
self NOUN B-O
- PUNCT B-O
reported VERB B-O
history NOUN B-O
of ADP B-O
DM PROPN B-AC
( PUNCT B-O
normal ADJ B-O
FPG PROPN B-AC
group NOUN B-O
: PUNCT B-O
FPG PROPN B-AC
< ADP B-O
5.6 NUM B-O
mmol NOUN B-O
/ SYM B-O
L NOUN B-O
and CCONJ B-O
no DET B-O
self NOUN B-O
- PUNCT B-O
reported VERB B-O
history NOUN B-O
of ADP B-O
DM PROPN B-AC
; PUNCT B-O
impaired ADJ B-LF
fasting ADJ I-LF
glucose NOUN I-LF
[ PUNCT B-O
IFG PROPN B-AC
] PUNCT B-O
: PUNCT B-O
FPG PROPN B-AC
5.6–6.9 NUM B-O
mmol NOUN B-O
/ SYM B-O
L NOUN B-O
and CCONJ B-O
no DET B-O
self NOUN B-O
- PUNCT B-O
reported VERB B-O
history NOUN B-O
of ADP B-O
DM PROPN B-AC
; PUNCT B-O
and CCONJ B-O
DM PROPN B-AC
: PUNCT B-O
FPG PROPN B-AC
≥ ADP B-O
7.0 NUM B-O
mmol NOUN B-O
/ SYM B-O
L NOUN B-O
or CCONJ B-O
self NOUN B-O
- PUNCT B-O
reported VERB B-O
history NOUN B-O
of ADP B-O
DM PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

Our PRON B-O
results NOUN B-O
demonstrate VERB B-O
that SCONJ B-O
the DET B-O
long ADJ B-O
- PUNCT B-O
term NOUN B-O
expression NOUN B-O
of ADP B-O
disease NOUN B-O
- PUNCT B-O
causing VERB B-O
misfolded ADJ B-O
proteins NOUN B-O
can AUX B-O
lead VERB B-O
to ADP B-O
an DET B-O
abnormal ADJ B-O
, PUNCT B-O
chronic ADJ B-O
stress NOUN B-O
response NOUN B-O
that SCONJ B-O
we PRON B-O
now ADV B-O
refer VERB B-O
to ADP B-O
as ADP B-O
the DET B-O
maladaptive ADJ B-LF
stress NOUN I-LF
response NOUN I-LF
( PUNCT B-O
MSR PROPN B-AC
) PUNCT B-O
. PUNCT B-O
This DET B-O
altered ADJ B-O
Q NOUN B-O
- PUNCT B-O
state NOUN B-O
[ PUNCT B-O
3]–[6 X B-O
] PUNCT B-O
, PUNCT B-O
which PRON B-O
emphasizes VERB B-O
that SCONJ B-O
the DET B-O
structure NOUN B-O
of ADP B-O
a DET B-O
protein NOUN B-O
is AUX B-O
tightly ADV B-O
integrated VERB B-O
with ADP B-O
a DET B-O
dynamic ADJ B-O
proteostatic ADJ B-O
system NOUN B-O
[ PUNCT B-O
1],[5],[6],[9 NUM B-O
] PUNCT B-O
, PUNCT B-O
negatively ADV B-O
impacts VERB B-O
the DET B-O
folding NOUN B-O
of ADP B-O
disease NOUN B-O
- PUNCT B-O
associated VERB B-O
proteins NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
F508del PROPN B-O
- PUNCT B-O
CFTR PROPN B-AC
[ PUNCT B-O
42 NUM B-O
] PUNCT B-O
, PUNCT B-O
leading VERB B-O
to ADP B-O
a DET B-O
self NOUN B-O
- PUNCT B-O
propagating VERB B-O
proteotoxic ADJ B-O
crisis NOUN B-O
( PUNCT B-O
Figure PROPN B-O
8) NUM B-O
. PUNCT B-O

OPSCC PROPN B-AC
, PUNCT B-O
oropharyngeal ADJ B-LF
squamous ADJ I-LF
cell NOUN I-LF
carcinoma NOUN I-LF
; PUNCT B-O
HPV PROPN B-AC
, PUNCT B-O
human ADJ B-LF
papillomavirus NOUN I-LF
; PUNCT B-O
FFPE PROPN B-AC
, PUNCT B-O
formalin NOUN B-LF
- PUNCT I-LF
fixed VERB I-LF
, PUNCT I-LF
paraffin NOUN I-LF
- PUNCT I-LF
embedded VERB I-LF
; PUNCT B-O
IHC PROPN B-AC
, PUNCT B-O
immunohistochemical ADJ B-LF
staining NOUN I-LF
; PUNCT B-O
PCR NOUN B-AC
- PUNCT B-AC
MA PROPN B-AC
, PUNCT B-O
multiplex ADJ B-LF
PCR NOUN I-LF
- PUNCT I-LF
MassArray PROPN I-LF
. PUNCT B-O

AM INTJ B-AC
, PUNCT B-O
acute ADJ B-LF
malnutrition NOUN I-LF
. PUNCT B-O

Paper NOUN B-LF
- PUNCT I-LF
based VERB I-LF
Data PROPN I-LF
Capture PROPN I-LF
( PUNCT B-O
PDC PROPN B-AC
) PUNCT B-O
has AUX B-O
historically ADV B-O
been AUX B-O
the DET B-O
main ADJ B-O
method NOUN B-O
used VERB B-O
to PART B-O
record VERB B-O
information NOUN B-O
. PUNCT B-O

Naïve ADJ B-O
T PROPN B-O
cells NOUN B-O
require VERB B-O
activation NOUN B-O
by ADP B-O
dendritic ADJ B-LF
cells NOUN I-LF
( PUNCT B-O
DCs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
AHR PROPN B-AC
ligands NOUN B-O
modulate VERB B-O
the DET B-O
function NOUN B-O
of ADP B-O
DCs PROPN B-AC
from ADP B-O
adult ADJ B-O
organisms NOUN B-O
. PUNCT B-O

6MWT PROPN B-AC
: PUNCT B-O
6 NUM B-LF
- PUNCT I-LF
minute NOUN I-LF
walk NOUN I-LF
test NOUN I-LF
( PUNCT B-O
m NOUN B-O
: PUNCT B-O
distance NOUN B-O
in ADP B-O
meters NOUN B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
the DET B-O
past ADJ B-O
decades NOUN B-O
, PUNCT B-O
quantitative ADJ B-LF
EEG PROPN I-LF
( PUNCT B-O
qEEG PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
methods NOUN B-O
have AUX B-O
been AUX B-O
developed VERB B-O
to PART B-O
identify VERB B-O
epilepsy NOUN B-O
- PUNCT B-O
related VERB B-O
signals NOUN B-O
[ X B-O
9–14 NUM B-O
] PUNCT B-O
. PUNCT B-O
qEEG PROPN B-AC
is AUX B-O
more ADV B-O
objective ADJ B-O
than ADP B-O
visual ADJ B-O
analysis NOUN B-O
and CCONJ B-O
may AUX B-O
reveal VERB B-O
subtle ADJ B-O
signal NOUN B-O
features NOUN B-O
and CCONJ B-O
dynamics NOUN B-O
that PRON B-O
are AUX B-O
difficult ADJ B-O
or CCONJ B-O
impossible ADJ B-O
to PART B-O
detect VERB B-O
by ADP B-O
visual ADJ B-O
inspection NOUN B-O
. PUNCT B-O

HR NOUN B-AC
, PUNCT B-O
hazard NOUN B-LF
ratio NOUN I-LF
. PUNCT B-O

In ADP B-O
2006 NUM B-O
, PUNCT B-O
the DET B-O
World PROPN B-LF
Health PROPN I-LF
Organization PROPN I-LF
( PUNCT B-O
WHO PROPN B-AC
) PUNCT B-O
recognised VERB B-O
SCA PROPN B-AC
as ADP B-O
a DET B-O
global ADJ B-O
public ADJ B-O
health NOUN B-O
problem NOUN B-O
[ PUNCT B-O
18 NUM B-O
] PUNCT B-O
. PUNCT B-O

RNA NOUN B-O
prepared VERB B-O
from ADP B-O
epidydimis PROPN B-O
was AUX B-O
used VERB B-O
as ADP B-O
positive ADJ B-O
control NOUN B-O
of ADP B-O
Hoxa1 PROPN B-O
and CCONJ B-O
Hoxb1 PROPN B-O
. PUNCT B-O
cDNA NOUN B-O
products NOUN B-O
were AUX B-O
resolved VERB B-O
on ADP B-O
2 NUM B-O
% NOUN B-O
( PUNCT B-O
w NOUN B-O
/ SYM B-O
v NOUN B-O
) PUNCT B-O
agarose NOUN B-O
gels NOUN B-O
. PUNCT B-O
cDNA NOUN B-O
, PUNCT B-O
complementary ADJ B-O
DNA NOUN B-O
; PUNCT B-O
HTF PROPN B-AC
, PUNCT B-O
human ADJ B-LF
tubal ADJ I-LF
fluid NOUN I-LF
; PUNCT B-O
PC PROPN B-O
, PUNCT B-O
positive ADJ B-O
control NOUN B-O
; PUNCT B-O
RT NOUN B-AC
- PUNCT B-AC
PCR NOUN B-AC
, PUNCT B-O
reverse ADJ B-O
transcription NOUN B-O
PCR NOUN B-O
; PUNCT B-O
TLR7/8 PROPN B-AC
, PUNCT B-O
Toll NOUN B-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
7 NUM I-LF
/ SYM I-LF
Toll NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
receptor NOUN I-LF
8 NUM I-LF
. PUNCT B-O

BBS4 PROPN B-AC
, PUNCT B-O
Bardet PROPN B-LF
– PUNCT I-LF
Biedl PROPN I-LF
syndrome PROPN I-LF
4 NUM I-LF
; PUNCT B-O
NRF2 PROPN B-AC
, PUNCT B-O
nuclear ADJ B-LF
factor NOUN I-LF
- PUNCT I-LF
erythroid NOUN I-LF
2 NUM I-LF
- PUNCT I-LF
like ADJ I-LF
2 NUM I-LF
. PUNCT B-O

FSC PROPN B-O
- PUNCT B-O
A PROPN B-O
, PUNCT B-O
forward ADJ B-O
scatter NOUN B-O
area NOUN B-O
; PUNCT B-O
FSC PROPN B-O
- PUNCT B-O
H PROPN B-O
, PUNCT B-O
forward ADJ B-O
scatter NOUN B-O
height NOUN B-O
; PUNCT B-O
Hoxa11 PROPN B-AC
, PUNCT B-O
Homeobox PROPN B-LF
a11 NOUN I-LF
; PUNCT B-O
NK PROPN B-AC
, PUNCT B-O
natural ADJ B-LF
killer NOUN I-LF
; PUNCT B-O
Treg PROPN B-AC
, PUNCT B-O
T PROPN B-LF
regulatory ADJ I-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
. PUNCT B-O

CBV PROPN B-AC
, PUNCT B-O
cerebral ADJ B-LF
blood NOUN I-LF
volume NOUN I-LF
; PUNCT B-O
NIRS PROPN B-AC
, PUNCT B-O
near ADJ B-LF
- PUNCT I-LF
infrared ADJ I-LF
spectroscopy NOUN I-LF
. PUNCT B-O

The DET B-O
C NOUN B-LF
- ADJ I-LF
terminal ADJ I-LF
fragment NOUN I-LF
of ADP I-LF
ubiquitin NOUN I-LF
( PUNCT B-O
Cub PROPN B-AC
) PUNCT B-O
was AUX B-O
fused VERB B-O
to ADP B-O
either CCONJ B-O
the DET B-O
N- NOUN B-O
or CCONJ B-O
C NOUN B-O
- ADJ B-O
terminal ADJ B-O
end NOUN B-O
of ADP B-O
Stt7 PROPN B-O
and CCONJ B-O
expressed VERB B-O
in ADP B-O
yeast NOUN B-O
together ADV B-O
with SCONJ B-O
the DET B-O
N NOUN B-LF
- ADJ I-LF
terminal ADJ I-LF
end NOUN I-LF
of ADP I-LF
ubiquitin NOUN I-LF
( PUNCT B-O
Nub PROPN B-AC
) PUNCT B-O
fused VERB B-O
to ADP B-O
the DET B-O
C NOUN B-O
- ADJ B-O
terminal ADJ B-O
end NOUN B-O
of ADP B-O
the DET B-O
endoplasmic ADJ B-O
reticulum NOUN B-O
( PUNCT B-O
ER PROPN B-O
) PUNCT B-O
protein NOUN B-O
Alg5 PROPN B-O
, PUNCT B-O
which PRON B-O
places VERB B-O
Nub PROPN B-AC
on ADP B-O
the DET B-O
cytoplasmic ADJ B-O
side NOUN B-O
of ADP B-O
the DET B-O
membrane NOUN B-O
. PUNCT B-O

Of ADP B-O
all DET B-O
ABMR PROPN B-AC
episodes NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
12 NUM B-O
) PUNCT B-O
, PUNCT B-O
2 NUM B-O
were AUX B-O
associated VERB B-O
with ADP B-O
antibodies NOUN B-O
to ADP B-O
angiotensin NOUN B-LF
II NUM I-LF
type NOUN I-LF
1 NUM I-LF
receptor NOUN I-LF
( PUNCT B-O
AT1R PROPN B-AC
) PUNCT B-O
and CCONJ B-O
one NUM B-O
with ADP B-O
an DET B-O
ABO PROPN B-O
- PUNCT B-O
incompatible ADJ B-O
transplant NOUN B-O
. PUNCT B-O

Reduced VERB B-O
long ADJ B-LF
- PUNCT I-LF
term NOUN I-LF
depression NOUN I-LF
( PUNCT B-O
LTD NOUN B-AC
) PUNCT B-O
was AUX B-O
recently ADV B-O
reported VERB B-O
in ADP B-O
TSC PROPN B-AC
mutant ADJ B-O
mice NOUN B-O
. PUNCT B-O

There PRON B-O
was AUX B-O
no DET B-O
difference NOUN B-O
between ADP B-O
the DET B-O
genotypes NOUN B-O
with ADP B-O
regard NOUN B-O
to ADP B-O
T PROPN B-O
cell NOUN B-O
survival NOUN B-O
( PUNCT B-O
Figure PROPN B-O
6A NUM B-O
) PUNCT B-O
. PUNCT B-O
Proliferative ADJ B-O
ability NOUN B-O
was AUX B-O
addressed VERB B-O
by ADP B-O
stimulating VERB B-O
purified ADJ B-O
B PROPN B-O
cells NOUN B-O
with ADP B-O
anti ADJ B-O
- ADJ B-O
μ ADJ B-O
F(ab′)2 NOUN B-O
or CCONJ B-O
lipopolysaccharide NOUN B-LF
( PUNCT B-O
LPS PROPN B-AC
) PUNCT B-O
and CCONJ B-O
measuring VERB B-O
3H NOUN B-O
- ADJ B-O
thymidine NOUN B-O
incorporation NOUN B-O
( PUNCT B-O
Figure PROPN B-O
6C NUM B-O
) PUNCT B-O
. PUNCT B-O
c NOUN B-O
- ADJ B-O
IAP2H570A NOUN B-O
/ SYM B-O
H570A PROPN B-O
B PROPN B-O
cells NOUN B-O
had VERB B-O
enhanced VERB B-O
responses NOUN B-O
to ADP B-O
both DET B-O
stimuli NOUN B-O
, PUNCT B-O
with ADP B-O
approximately ADV B-O
a PRON B-O
3 ADV B-O
- ADJ B-O
fold ADJ B-O
shift NOUN B-O
in ADP B-O
the DET B-O
dose NOUN B-O
response NOUN B-O
curve NOUN B-O
toward ADP B-O
lesser ADJ B-O
concentrations NOUN B-O
of ADP B-O
stimulus NOUN B-O
compared VERB B-O
to ADP B-O
wild ADJ B-O
type NOUN B-O
cells NOUN B-O
. PUNCT B-O

In ADP B-O
this DET B-O
study NOUN B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
gene NOUN B-LF
set NOUN I-LF
enrichment NOUN I-LF
analysis NOUN I-LF
( PUNCT B-O
GSEA PROPN B-AC
) PUNCT B-O
[ X B-O
39 NUM B-O
] X B-O
to PART B-O
explore VERB B-O
a DET B-O
gene NOUN B-O
expression NOUN B-O
data NOUN B-O
set NOUN B-O
derived VERB B-O
from ADP B-O
endoscopic ADJ B-O
biopsies NOUN B-O
of ADP B-O
polypoid ADJ B-O
and CCONJ B-O
nonpolypoid ADJ B-O
colorectal ADJ B-O
adenomas NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
APGAR PROPN B-AC
, PUNCT B-O
appearance NOUN B-LF
, PUNCT I-LF
pulse NOUN I-LF
, PUNCT I-LF
grimace NOUN I-LF
, PUNCT I-LF
activity NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
respiration NOUN I-LF
; PUNCT B-O
CBS PROPN B-AC
, PUNCT B-O
Statistics PROPN B-LF
Netherlands PROPN I-LF
; PUNCT B-O
CI PROPN B-AC
, PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
CIN PROPN B-AC
, PUNCT B-O
cervical ADJ B-LF
intraepithelial ADJ I-LF
neoplasia NOUN I-LF
; PUNCT B-O
IVF PROPN B-AC
, PUNCT B-O
in ADP B-LF
vitro X I-LF
fertilization NOUN I-LF
; PUNCT B-O
NICU PROPN B-O
, PUNCT B-O
neonatal ADJ B-O
intensive PROPN B-O
care NOUN B-O
unit NOUN B-O
; PUNCT B-O
pPROM NOUN B-AC
, PUNCT B-O
preterm ADJ B-LF
premature ADJ I-LF
rupture NOUN I-LF
of ADP I-LF
membranes NOUN I-LF
. PUNCT B-O

OPD PROPN B-AC
: PUNCT B-O
o NOUN B-LF
- NOUN I-LF
phenylenediamine NOUN I-LF
dihydrochloride NOUN I-LF
. PUNCT B-O
( PUNCT B-O
C NOUN B-O
) PUNCT B-O
Px43 NOUN B-O
IgG1 NOUN B-O
and CCONJ B-O
IgG4 NOUN B-O
demonstrate VERB B-O
different ADJ B-O
relative ADJ B-O
affinities NOUN B-O
by ADP B-O
ELISA PROPN B-O
but CCONJ B-O
comparable ADJ B-O
affinity NOUN B-O
by ADP B-O
IIF PROPN B-AC
binding VERB B-O
of ADP B-O
human ADJ B-O
skin NOUN B-O
. PUNCT B-O

Among ADP B-O
325 NUM B-O
medical ADJ B-O
records NOUN B-O
identified VERB B-O
and CCONJ B-O
examined VERB B-O
, PUNCT B-O
292 NUM B-O
( PUNCT B-O
89.8 NUM B-O
% NOUN B-O
) PUNCT B-O
patients NOUN B-O
from ADP B-O
12 NUM B-O
different ADJ B-O
non ADJ B-O
- PUNCT B-O
Arabic ADJ B-O
- PUNCT B-O
speaking VERB B-O
tribes NOUN B-O
disclosed VERB B-O
in ADP B-O
the DET B-O
medical ADJ B-O
notes NOUN B-O
that SCONJ B-O
they PRON B-O
had AUX B-O
been AUX B-O
attacked VERB B-O
by ADP B-O
Government PROPN B-LF
of ADP I-LF
Sudan PROPN I-LF
( PUNCT B-O
GoS PROPN B-AC
) PUNCT B-O
and/or CCONJ B-O
Janjaweed PROPN B-O
forces NOUN B-O
. PUNCT B-O

Data NOUN B-O
on ADP B-O
the DET B-O
lifetime NOUN B-O
presence NOUN B-O
and CCONJ B-O
age NOUN B-O
- PUNCT B-O
of ADP B-O
- PUNCT B-O
onset NOUN B-O
of ADP B-O
Diagnostic PROPN B-LF
and CCONJ I-LF
Statistical PROPN I-LF
Manual PROPN I-LF
of ADP I-LF
Mental PROPN I-LF
Disorders PROPN I-LF
, PUNCT I-LF
4th PROPN I-LF
Edition PROPN I-LF
( PUNCT B-O
DSM PROPN B-AC
- PUNCT B-AC
IV PROPN B-AC
) PUNCT B-O
mental ADJ B-O
disorders NOUN B-O
and CCONJ B-O
nonfatal ADJ B-O
suicidal ADJ B-O
behaviors NOUN B-O
were AUX B-O
collected VERB B-O
via ADP B-O
structured ADJ B-O
face NOUN B-O
- PUNCT B-O
to ADP B-O
- PUNCT B-O
face NOUN B-O
interviews NOUN B-O
with ADP B-O
108,664 NUM B-O
respondents NOUN B-O
from ADP B-O
21 NUM B-O
countries NOUN B-O
participating VERB B-O
in ADP B-O
the DET B-O
WHO PROPN B-O
World PROPN B-O
Mental PROPN B-O
Health PROPN B-O
Surveys PROPN B-O
. PUNCT B-O

Incremental ADJ B-LF
cost NOUN I-LF
- PUNCT I-LF
effectiveness NOUN I-LF
ratios NOUN I-LF
( PUNCT B-O
ICERs NOUN B-AC
) PUNCT B-O
were AUX B-O
reported VERB B-O
separately ADV B-O
for ADP B-O
the DET B-O
four NUM B-O
LOS PROPN B-AC
models NOUN B-O
( PUNCT B-O
2 NUM B-O
, PUNCT B-O
6 NUM B-O
, PUNCT B-O
24 NUM B-O
, PUNCT B-O
36 NUM B-O
months NOUN B-O
) PUNCT B-O
. PUNCT B-O

Finally ADV B-O
, PUNCT B-O
the DET B-O
Na+ NOUN B-O
channel NOUN B-O
blocker NOUN B-O
tetrodotoxin NOUN B-LF
( PUNCT B-O
TTX PROPN B-AC
) PUNCT B-O
was AUX B-O
added VERB B-O
to PART B-O
the DET B-O
MEA PROPN B-AC
and CCONJ B-O
perfusion NOUN B-O
media NOUN B-O
to PART B-O
suppress VERB B-O
spontaneous ADJ B-O
network NOUN B-O
activity NOUN B-O
, PUNCT B-O
and CCONJ B-O
imaging NOUN B-O
was AUX B-O
continued VERB B-O
for ADP B-O
additional ADJ B-O
1–2 NUM B-O
d. NOUN B-O

BMI- PROPN B-AC
Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
, PUNCT B-O
WC- PROPN B-AC
Waist NOUN B-LF
circumference NOUN I-LF
, PUNCT B-O
WHR- NOUN B-AC
Waist NOUN B-LF
hip NOUN I-LF
ratio NOUN I-LF
, PUNCT B-O
MET PROPN B-O
– PUNCT B-O
Metabolic PROPN B-O
Equivalent PROPN B-O
, PUNCT B-O
SD NOUN B-O
– PUNCT B-O
standard ADJ B-O
deviation NOUN B-O

The DET B-O
survey NOUN B-O
instrument NOUN B-O
was AUX B-O
adapted VERB B-O
from ADP B-O
the DET B-O
Zambia PROPN B-O
Demographic PROPN B-LF
and CCONJ I-LF
Health PROPN I-LF
Surveys PROPN I-LF
( PUNCT B-O
DHS PROPN B-AC
) PUNCT B-O
[ X B-O
22 NUM B-O
] X B-O
and CCONJ B-O
comprised VERB B-O
three NUM B-O
parts NOUN B-O
. PUNCT B-O

On ADP B-O
chromosome NOUN B-O
6A NOUN B-O
a DET B-O
locus NOUN B-O
was AUX B-O
detected VERB B-O
for ADP B-O
DSB NOUN B-AC
and CCONJ B-O
HI NOUN B-AC
in ADP B-O
the DET B-O
north NOUN B-O
and CCONJ B-O
the DET B-O
south NOUN B-O
reducing VERB B-O
the DET B-O
number NOUN B-LF
of ADP I-LF
days NOUN I-LF
from ADP I-LF
sowing VERB I-LF
to ADP I-LF
booting NOUN I-LF
and CCONJ B-O
increasing VERB B-O
HI NOUN B-AC
. PUNCT B-O
Chromosome NOUN B-O
6B NUM B-O
reported VERB B-O
the DET B-O
highest ADJ B-O
number NOUN B-O
of ADP B-O
regions NOUN B-O
with ADP B-O
stable ADJ B-O
MTAs NOUN B-AC
( PUNCT B-O
3 NUM B-O
) PUNCT B-O
. PUNCT B-O

OPV PROPN B-AC
, PUNCT B-O
oral ADJ B-LF
poliovirus NOUN I-LF
vaccine NOUN I-LF
. PUNCT B-O

CID NOUN B-AC
, PUNCT B-O
complexity NOUN B-O
invariant ADJ B-O
distance NOUN B-O
; PUNCT B-O
DTW PROPN B-AC
, PUNCT B-O
dynamic ADJ B-LF
time NOUN I-LF
warping VERB I-LF
distance NOUN B-O
; PUNCT B-O
variance NOUN B-O
, PUNCT B-O
fraction NOUN B-O
of ADP B-O
variance NOUN B-O
explained VERB B-O
by ADP B-O
the DET B-O
clustering NOUN B-O
; PUNCT B-O
silhouette NOUN B-O
, PUNCT B-O
average ADJ B-O
silhouette NOUN B-O
width NOUN B-O
for ADP B-O
all DET B-O
glycemic ADJ B-O
signature NOUN B-O
; PUNCT B-O
CH PROPN B-AC
index NOUN B-O
, PUNCT B-O
Calinski PROPN B-LF
- PUNCT I-LF
Harabasz PROPN I-LF
index NOUN B-O
. PUNCT B-O

If SCONJ B-O
we PRON B-O
assume VERB B-O
that SCONJ B-O
the DET B-O
particles NOUN B-O
are AUX B-O
rigid ADJ B-O
spherical ADJ B-O
, PUNCT B-O
the DET B-O
correlation NOUN B-O
between ADP B-O
DM PROPN B-AC
specific ADJ B-O
resistance NOUN B-O
and CCONJ B-O
DM PROPN B-LF
layer NOUN I-LF
porosity NOUN I-LF
can AUX B-O
be AUX B-O
described VERB B-O
by ADP B-O
Carman PROPN B-O
- PUNCT B-O
Kozeny PROPN B-O
equation NOUN B-O
[ X B-O
26 NUM B-O
] PUNCT B-O
. PUNCT B-O
α=180(1−εp)ρpdp2εp3(8 NOUN B-AC
) PUNCT B-O
where SCONJ B-O
ε NOUN B-O
p NOUN B-O
is AUX B-O
the DET B-O
porosity NOUN B-O
of ADP B-O
DM PROPN B-AC
layer NOUN B-O
, PUNCT B-O
ρ NOUN B-O
p NOUN B-O
is AUX B-O
the DET B-O
density NOUN B-O
of ADP B-O
particle NOUN B-O
( PUNCT B-O
kg NOUN B-O
/ SYM B-O
m3 NOUN B-O
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
d NOUN B-O
p NOUN B-O
is AUX B-O
the DET B-O
particle NOUN B-O
diameter NOUN B-O
( PUNCT B-O
m NOUN B-O
) PUNCT B-O
. PUNCT B-O

We PRON B-O
conducted VERB B-O
an DET B-O
acceptability NOUN B-O
, PUNCT B-O
feasibility NOUN B-O
, PUNCT B-O
and CCONJ B-O
prevalence NOUN B-O
study NOUN B-O
of ADP B-O
home NOUN B-O
- PUNCT B-O
based VERB B-O
sampling NOUN B-O
for ADP B-O
STIs PROPN B-AC
/ SYM B-O
BV PROPN B-AC
among ADP B-O
young ADJ B-O
men NOUN B-O
and CCONJ B-O
women NOUN B-O
aged VERB B-O
15–24 NUM B-O
years NOUN B-O
old ADJ B-O
in ADP B-O
a DET B-O
health NOUN B-LF
and CCONJ I-LF
demographic ADJ I-LF
surveillance NOUN I-LF
site NOUN I-LF
( PUNCT B-O
HDSS PROPN B-AC
) PUNCT B-O
in ADP B-O
rural ADJ B-O
KwaZulu PROPN B-O
- PUNCT B-O
Natal PROPN B-O
, PUNCT B-O
South PROPN B-O
Africa PROPN B-O
. PUNCT B-O

Sn PROPN B-AC
, PUNCT B-O
sensitivitiy NOUN B-O
; PUNCT B-O
Sp PROPN B-AC
, PUNCT B-O
specificity NOUN B-LF
; PUNCT B-O
PPV NOUN B-AC
, PUNCT B-O
positive ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
; PUNCT B-O
NPV NOUN B-AC
, PUNCT B-O
negative ADJ B-LF
predictive ADJ I-LF
value NOUN I-LF
; PUNCT B-O
AUC NOUN B-AC
, PUNCT B-O
area NOUN B-O
under ADP B-O
the DET B-O
curve NOUN B-O
; PUNCT B-O
AFP PROPN B-AC
, PUNCT B-O
alpha NOUN B-LF
- PUNCT I-LF
fetoprotein NOUN I-LF
; PUNCT B-O
PIVKA PROPN B-AC
- PUNCT B-AC
II PROPN B-AC
, PUNCT B-O
protein NOUN B-LF
induced VERB I-LF
by ADP I-LF
vitamin NOUN I-LF
K NOUN I-LF
absence NOUN I-LF
; PUNCT B-O
OPN PROPN B-AC
, PUNCT B-O
osteopontin NOUN B-LF
; PUNCT B-O
DKK-1 PROPN B-AC
, PUNCT B-O
Dickkopf PROPN B-O
-1 NUM B-O

¶LAD X B-AC
— PUNCT B-O
left VERB B-LF
atrial ADJ I-LF
diameter NOUN I-LF

To PART B-O
address VERB B-O
this DET B-O
question NOUN B-O
, PUNCT B-O
we PRON B-O
utilize VERB B-O
a DET B-O
“ PUNCT B-O
Big ADJ B-O
Data PROPN B-O
” PUNCT B-O
set NOUN B-O
of ADP B-O
all DET B-O
discharge NOUN B-LF
summary NOUN I-LF
reports NOUN I-LF
( PUNCT B-O
DSRs PROPN B-AC
) PUNCT B-O
from ADP B-O
43 NUM B-O
tertiary ADJ B-O
general ADJ B-O
hospitals NOUN B-O
, PUNCT B-O
from ADP B-O
January PROPN B-O
1 NUM B-O
, PUNCT B-O
2010 NUM B-O
to ADP B-O
December PROPN B-O
31 NUM B-O
, PUNCT B-O
2012 NUM B-O
. PUNCT B-O

Moderate ADJ B-LF
acute ADJ I-LF
malnutrition NOUN I-LF
( PUNCT B-O
MAM PROPN B-AC
) PUNCT B-O
is AUX B-O
defined VERB B-O
as ADP B-O
a DET B-O
WHZ<−2 NUM B-AC
WHZ NOUN B-AC
but CCONJ B-O
≥−3 NUM B-O
WHZ NOUN B-AC
using VERB B-O
the DET B-O
WHO PROPN B-O
Child PROPN B-O
Growth PROPN B-O
Standards PROPN B-O
. PUNCT B-O

The DET B-O
whole ADJ B-LF
exome NOUN I-LF
sequencing NOUN I-LF
( PUNCT B-O
WES PROPN B-AC
) PUNCT B-O
approach NOUN B-O
was AUX B-O
taken VERB B-O
, PUNCT B-O
with ADP B-O
a DET B-O
view NOUN B-O
to ADP B-O
the DET B-O
molecular ADJ B-O
background NOUN B-O
of ADP B-O
the DET B-O
proband NOUN B-O
’s PART B-O
complex ADJ B-O
phenotype NOUN B-O
( PUNCT B-O
of ADP B-O
moderate ADJ B-O
peripheral ADJ B-O
neuropathy NOUN B-O
and CCONJ B-O
mental ADJ B-O
retardation NOUN B-O
) PUNCT B-O
being AUX B-O
understood VERB B-O
. PUNCT B-O

Our PRON B-O
data NOUN B-O
exemplify VERB B-O
that SCONJ B-O
( PUNCT B-O
i X B-O
) PUNCT B-O
Ginir PROPN B-AC
RNA NOUN B-O
function NOUN B-O
is AUX B-O
modulated VERB B-O
by ADP B-O
its PRON B-O
full ADJ B-O
- PUNCT B-O
length NOUN B-O
natural ADJ B-LF
antisense ADJ I-LF
transcript NOUN I-LF
( PUNCT B-O
NAT PROPN B-AC
; PUNCT B-O
Giniras PROPN B-AC
) PUNCT B-O
, PUNCT B-O
( PUNCT B-O
ii X B-O
) PUNCT B-O
Ginir PROPN B-AC
RNA NOUN B-O
targets VERB B-O
centrosomal ADJ B-LF
protein NOUN I-LF
112 NUM I-LF
( PUNCT B-O
Cep112 PROPN B-AC
) PUNCT B-O
and CCONJ B-O
alters VERB B-O
its PRON B-O
subcellular ADJ B-O
localisation NOUN B-O
by ADP B-O
binding VERB B-O
to ADP B-O
it PRON B-O
, PUNCT B-O
( PUNCT B-O
iii X B-O
) PUNCT B-O
breast NOUN B-LF
cancer NOUN I-LF
type NOUN I-LF
1 NUM I-LF
susceptibility NOUN I-LF
protein NOUN I-LF
( PUNCT B-O
Brca1 NOUN B-AC
) PUNCT B-O
and CCONJ B-O
Cep112 PROPN B-AC
proteins NOUN B-O
interact VERB B-O
with ADP B-O
each DET B-O
other ADJ B-O
in ADP B-O
the DET B-O
absence NOUN B-O
of ADP B-O
Ginir PROPN B-AC
noncoding ADJ B-O
RNA NOUN B-O
, PUNCT B-O
( PUNCT B-O
iv X B-O
) PUNCT B-O
interaction NOUN B-O
of ADP B-O
Cep112 PROPN B-AC
protein NOUN B-O
with ADP B-O
Brca1 NOUN B-AC
protein NOUN B-O
is AUX B-O
impaired VERB B-O
in ADP B-O
the DET B-O
presence NOUN B-O
of ADP B-O
high ADJ B-O
levels NOUN B-O
of ADP B-O
Ginir PROPN B-AC
RNA NOUN B-O
, PUNCT B-O
and CCONJ B-O
( PUNCT B-O
v X B-O
) PUNCT B-O
interference NOUN B-O
of ADP B-O
Cep112 PROPN B-AC
– SYM B-O
Brca1 NOUN B-AC
interaction NOUN B-O
due ADP B-O
to ADP B-O
increased VERB B-O
presence NOUN B-O
of ADP B-O
Ginir PROPN B-AC
RNA NOUN B-O
causes VERB B-O
replicative ADJ B-O
stress NOUN B-O
and CCONJ B-O
induces VERB B-O
mitotic ADJ B-O
dysregulation NOUN B-O
, PUNCT B-O
causing VERB B-O
genomic ADJ B-O
instability NOUN B-O
, PUNCT B-O
and CCONJ B-O
thereby ADV B-O
propels VERB B-O
cells NOUN B-O
towards ADP B-O
malignant ADJ B-O
transformation NOUN B-O
. PUNCT B-O

Tumors NOUN B-O
were AUX B-O
staged VERB B-O
based VERB B-O
upon SCONJ B-O
the DET B-O
sixth ADJ B-O
or CCONJ B-O
seventh ADJ B-O
tumor NOUN B-LF
– PUNCT I-LF
node NOUN I-LF
– PUNCT I-LF
metastasis NOUN I-LF
( PUNCT B-O
TNM PROPN B-AC
) PUNCT B-O
classification NOUN B-O
of ADP B-O
the DET B-O
Union PROPN B-LF
for ADP I-LF
International PROPN I-LF
Cancer PROPN I-LF
Control PROPN I-LF
( PUNCT B-O
UICC PROPN B-AC
) PUNCT B-O
. PUNCT B-O
Operative ADJ B-O
time NOUN B-O
was AUX B-O
calculated VERB B-O
from ADP B-O
the DET B-O
electronic ADJ B-O
record NOUN B-O
on ADP B-O
the DET B-O
anesthesia NOUN B-O
machine NOUN B-O
from ADP B-O
the DET B-O
start NOUN B-O
of ADP B-O
creating VERB B-O
a DET B-O
pneumoperitoneum NOUN B-O
to ADP B-O
the DET B-O
end NOUN B-O
when SCONJ B-O
the DET B-O
abdominal ADJ B-O
incision NOUN B-O
being AUX B-O
sutured VERB B-O
. PUNCT B-O

Cataract NOUN B-O
extraction NOUN B-O
and CCONJ B-O
intraocular ADJ B-LF
lens NOUN I-LF
( PUNCT B-O
IOL PROPN B-AC
) PUNCT B-O
implantation NOUN B-O
could AUX B-O
thus ADV B-O
increase VERB B-O
the DET B-O
amount NOUN B-O
of ADP B-O
blue ADJ B-O
light NOUN B-O
that PRON B-O
reaches VERB B-O
retina NOUN B-O
. PUNCT B-O

The DET B-O
geometric ADJ B-O
mean ADJ B-O
parasite NOUN B-O
density NOUN B-O
at ADP B-O
baseline NOUN B-O
was AUX B-O
26,705 NUM B-O
/ NUM B-O
μl NOUN B-O
( PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
[ PUNCT B-O
CI NOUN B-AC
] PUNCT B-O
: PUNCT B-O
20,385 NUM B-O
to PART B-O
34,985 NUM B-O
) PUNCT B-O
. PUNCT B-O

GCN PROPN B-AC
, PUNCT B-O
gene NOUN B-LF
coexpression NOUN I-LF
network NOUN I-LF
; PUNCT B-O
MPS PROPN B-AC
, PUNCT B-O
mononuclear ADJ B-LF
phagocyte NOUN I-LF
system NOUN I-LF
; PUNCT B-O
RNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT B-O
RNA NOUN B-LF
sequencing NOUN I-LF
; PUNCT B-O
scRNA NOUN B-AC
- PUNCT B-AC
seq NOUN B-AC
, PUNCT B-O
single ADJ B-LF
- PUNCT I-LF
cell NOUN I-LF
RNA NOUN I-LF
- PUNCT I-LF
seq NOUN I-LF
. PUNCT B-O

On ADP B-O
the DET B-O
other ADJ B-O
hand NOUN B-O
, PUNCT B-O
enzymatic ADJ B-O
conversion NOUN B-O
of ADP B-O
EPA PROPN B-AC
and CCONJ B-O
DHA PROPN B-AC
can AUX B-O
yield VERB B-O
highly ADV B-O
potent ADJ B-O
lipid NOUN B-O
mediators NOUN B-O
: PUNCT B-O
CYP PROPN B-AC
catalyzed VERB B-O
epoxidation NOUN B-O
leads VERB B-O
e.g. X B-O
to ADP B-O
anti ADJ B-O
- ADJ B-O
arrhythmic ADJ B-O
acting VERB B-O
17(18)-epoxy NOUN B-LF
eicosatetraenoic NOUN I-LF
acid NOUN I-LF
( PUNCT B-O
EpETE PROPN B-AC
) PUNCT B-O
from ADP B-O
EPA PROPN B-AC
and CCONJ B-O
19(20)-epoxy NOUN B-LF
docosapentaenoic NOUN I-LF
acid NOUN I-LF
( PUNCT B-O
EpDPE PROPN B-AC
) PUNCT B-O
from ADP B-O
DHA PROPN B-AC
[ PUNCT B-O
12 NUM B-O
] PUNCT B-O
. PUNCT B-O

Nevertheless ADV B-O
, PUNCT B-O
the DET B-O
SGBIIA PROPN B-AC
cohort NOUN B-O
exhibited VERB B-O
a DET B-O
lower ADJ B-O
DM NOUN B-AC
risk NOUN B-O
after SCONJ B-O
we PRON B-O
adjusted ADJ B-O
for ADP B-O
the DET B-O
comorbidities NOUN B-O
of ADP B-O
hypertension NOUN B-O
, PUNCT B-O
hyperlipidemia NOUN B-O
, PUNCT B-O
and CCONJ B-O
coronary ADJ B-O
artery NOUN B-O
disease NOUN B-O
( PUNCT B-O
adjusted ADJ B-LF
hazard NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
aHR NOUN B-AC
): PUNCT B-O
0.56 NUM B-O
, PUNCT B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT B-O
CI NOUN B-AC
): PUNCT B-O
0.40–0.78 NUM B-O
) PUNCT B-O
. PUNCT B-O

Relatively ADV B-O
high ADJ B-O
concentrations NOUN B-O
of ADP B-O
phthalates NOUN B-O
were AUX B-O
reported VERB B-O
for ADP B-O
M. PROPN B-O
edulis PROPN B-O
and CCONJ B-O
C. PROPN B-O
edule PROPN B-O
, PUNCT B-O
26.36 NUM B-O
and CCONJ B-O
52.36 NUM B-O
ng NOUN B-O
g-1 NOUN B-O
, PUNCT B-O
with SCONJ B-O
concentrations NOUN B-O
of ADP B-O
polycyclic ADJ B-LF
aromatic ADJ I-LF
hydrocarbons NOUN I-LF
( PUNCT B-O
PAHs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
polybrominated ADJ B-LF
diphenyl NOUN I-LF
ethers NOUN I-LF
( PUNCT B-O
PBDEs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
polychlorinated ADJ B-LF
biphenyls NOUN I-LF
( PUNCT B-O
PCBs PROPN B-AC
) PUNCT B-O
substantially ADV B-O
lower ADJ B-O
for ADP B-O
both DET B-O
organisms NOUN B-O
[ PUNCT B-O
54 NUM B-O
] PUNCT B-O
. PUNCT B-O

We PRON B-O
have AUX B-O
previously ADV B-O
shown VERB B-O
that SCONJ B-O
activation NOUN B-O
of ADP B-O
the DET B-O
ligand NOUN B-O
- PUNCT B-O
dependent ADJ B-O
transcription NOUN B-O
factor NOUN B-O
aryl NOUN B-LF
hydrocarbon NOUN I-LF
receptor NOUN I-LF
( PUNCT B-O
AhR PROPN B-AC
) PUNCT B-O
by ADP B-O
the DET B-O
environmental ADJ B-O
pollutant NOUN B-O
2,3,7,8 NUM B-LF
- PUNCT I-LF
tetrachlorodibenzo NOUN I-LF
- PUNCT I-LF
p NOUN I-LF
- PUNCT I-LF
dioxin NOUN I-LF
( PUNCT B-O
TCDD PROPN B-AC
) PUNCT B-O
affects VERB B-O
both CCONJ B-O
oral ADJ B-O
tolerance NOUN B-O
and CCONJ B-O
food NOUN B-O
allergy NOUN B-O
. PUNCT B-O

Direction ADJ B-LF
selective ADJ I-LF
ganglion NOUN I-LF
cells NOUN I-LF
( PUNCT B-O
DSGCs NOUN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
retina NOUN B-O
are AUX B-O
important ADJ B-O
in ADP B-O
the DET B-O
processing NOUN B-O
of ADP B-O
motion NOUN B-O
information NOUN B-O
. PUNCT B-O

BMI PROPN B-AC
= PUNCT B-O
body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
; PUNCT B-O
CI PROPN B-AC
= PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
; PUNCT B-O
COR PROPN B-AC
= PUNCT B-O
crude ADJ B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT B-O
AOR NOUN B-AC
= PUNCT B-O
adjusted VERB B-LF
odds NOUN I-LF
ratio NOUN I-LF
; PUNCT B-O
TC PROPN B-AC
= PUNCT B-O
total ADJ B-LF
cholesterol NOUN I-LF
. PUNCT B-O

GM PROPN B-O
, PUNCT B-O
geometric ADJ B-O
mean NOUN B-O
; PUNCT B-O
GSD PROPN B-O
, PUNCT B-O
geometric ADJ B-O
standard ADJ B-O
deviation NOUN B-O
; PUNCT B-O
LOD PROPN B-AC
, PUNCT B-O
limit NOUN B-LF
of ADP I-LF
detection NOUN I-LF
. PUNCT B-O

Interestingly ADV B-O
, PUNCT B-O
the DET B-O
increased VERB B-O
glucose NOUN B-O
levels NOUN B-O
stress VERB B-O
the DET B-O
pancreatic ADJ B-O
islets NOUN B-O
and CCONJ B-O
insulin NOUN B-O
- PUNCT B-O
sensitive ADJ B-O
tissues NOUN B-O
, PUNCT B-O
leading VERB B-O
to ADP B-O
hyperproduction NOUN B-O
of ADP B-O
IL NOUN B-O
- PUNCT B-O
β NOUN B-O
via ADP B-O
nucleotide NOUN B-LF
- PUNCT I-LF
binding VERB I-LF
oligomerization NOUN I-LF
domain NOUN I-LF
- PUNCT I-LF
like ADJ I-LF
receptors- NOUN I-LF
, PUNCT I-LF
leucine NOUN I-LF
- PUNCT I-LF
rich ADJ I-LF
repeat- NOUN I-LF
, PUNCT I-LF
and CCONJ I-LF
pyrin NOUN I-LF
domain NOUN I-LF
– PUNCT I-LF
containing VERB I-LF
3 NUM I-LF
( PUNCT B-O
NLRP3 NOUN B-AC
) PUNCT B-O
inflammasome NOUN B-O
[ PUNCT B-O
4,5 NUM B-O
] PUNCT B-O
. PUNCT B-O

HO PROPN B-AC
, PUNCT B-O
High PROPN B-O
Nutrient NOUN B-O
Old PROPN B-O
Breeding PROPN B-O
treatment NOUN B-O
; PUNCT B-O
HY PROPN B-AC
, PUNCT B-O
High PROPN B-O
Nutrient NOUN B-O
Young PROPN B-O
Breeding PROPN B-O
treatment NOUN B-O
; PUNCT B-O
KLDC PROPN B-AC
, PUNCT B-O
Kullback PROPN B-LF
- PUNCT I-LF
Leibler PROPN I-LF
discrepancy NOUN I-LF
calibration NOUN I-LF
; PUNCT B-O
LO PROPN B-AC
, PUNCT B-O
Low PROPN B-O
Nutrient NOUN B-O
Old PROPN B-O
Breeding PROPN B-O
treatment NOUN B-O
; PUNCT B-O
LY PROPN B-AC
, PUNCT B-O
Low PROPN B-O
Nutrient NOUN B-O
Young PROPN B-O
Breeding PROPN B-O
treatment NOUN B-O
. PUNCT B-O

The DET B-O
current ADJ B-O
acute ADJ B-LF
kidney NOUN I-LF
injury NOUN I-LF
( PUNCT B-O
AKI PROPN B-AC
) PUNCT B-O
risk NOUN B-O
prediction NOUN B-O
model NOUN B-O
for ADP B-O
patients NOUN B-O
undergoing VERB B-O
percutaneous ADJ B-LF
coronary ADJ I-LF
intervention NOUN I-LF
( PUNCT B-O
PCI PROPN B-AC
) PUNCT B-O
from ADP B-O
the DET B-O
American PROPN B-LF
College PROPN I-LF
of ADP I-LF
Cardiology PROPN I-LF
( PUNCT B-O
ACC PROPN B-AC
) PUNCT B-O
National PROPN B-LF
Cardiovascular PROPN I-LF
Data PROPN I-LF
Registry PROPN I-LF
( PUNCT B-O
NCDR PROPN B-AC
) PUNCT B-O
employed VERB B-O
regression NOUN B-O
techniques NOUN B-O
. PUNCT B-O

BMP11 PROPN B-AC
, PUNCT B-O
Bone PROPN B-LF
Morphogenetic PROPN I-LF
Protein PROPN I-LF
11 NUM I-LF
; PUNCT B-O
RT NOUN B-O
- PUNCT B-O
PCR PROPN B-O
, PUNCT B-O
reverse ADJ B-O
transcription NOUN B-O
polymerase NOUN B-O
chain NOUN B-O
reaction NOUN B-O
; PUNCT B-O
Ubx PROPN B-AC
, PUNCT B-O
Ultrabithorax NOUN B-LF
. PUNCT B-O

For ADP B-O
the DET B-O
first ADJ B-O
time NOUN B-O
, PUNCT B-O
we PRON B-O
aimed VERB B-O
to PART B-O
assess VERB B-O
the DET B-O
stability NOUN B-O
of ADP B-O
21 NUM B-LF
- PUNCT I-LF
deoxycortisol NOUN I-LF
( PUNCT B-O
21Deox NOUN B-AC
) PUNCT B-O
, PUNCT B-O
11 NUM B-LF
- PUNCT I-LF
deoxycortisol NOUN I-LF
( PUNCT B-O
11Deox NOUN B-AC
) PUNCT B-O
, PUNCT B-O
4 NUM B-LF
- PUNCT I-LF
androstenedione NOUN I-LF
( PUNCT B-O
4AD NOUN B-AC
) PUNCT B-O
, PUNCT B-O
17 NUM B-LF
- PUNCT I-LF
hydroxyprogesterone NOUN I-LF
( PUNCT B-O
17OHP NOUN B-AC
) PUNCT B-O
and CCONJ B-O
cortisol NOUN B-LF
( PUNCT B-O
Cort NOUN B-AC
) PUNCT B-O
, PUNCT B-O
diagnostic ADJ B-O
for ADP B-O
CAH PROPN B-AC
, PUNCT B-O
in ADP B-O
dried VERB B-LF
blood NOUN I-LF
spots NOUN I-LF
( PUNCT B-O
DBSs PROPN B-AC
) PUNCT B-O
during ADP B-O
a DET B-O
1 NUM B-O
year NOUN B-O
storage NOUN B-O
at ADP B-O
different ADJ B-O
temperatures NOUN B-O
. PUNCT B-O

Considering VERB B-O
the DET B-O
expression NOUN B-O
of ADP B-O
DIP2A PROPN B-AC
in ADP B-O
embryonic ADJ B-O
and CCONJ B-O
early ADJ B-O
postnatal ADJ B-O
days NOUN B-O
, PUNCT B-O
we PRON B-O
speculate VERB B-O
that SCONJ B-O
DIP2A PROPN B-AC
also ADV B-O
affects VERB B-O
other ADJ B-O
processes NOUN B-O
of ADP B-O
neuronal ADJ B-O
development NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
the DET B-O
function NOUN B-O
of ADP B-O
the DET B-O
autism NOUN B-O
- NOUN B-O
associated VERB B-O
gene NOUN B-O
phosphatidylinositol NOUN B-LF
3,4,5 NUM I-LF
- NOUN I-LF
trisphosphate NOUN I-LF
- NOUN I-LF
dependent ADJ I-LF
Rac PROPN I-LF
exchanger NOUN I-LF
1 NUM I-LF
( PUNCT B-O
P PROPN B-AC
- NOUN B-AC
Rex1 PROPN B-AC
) PUNCT B-O
in ADP B-O
synaptic ADJ B-O
transmission NOUN B-O
and CCONJ B-O
neuronal ADJ B-O
migration NOUN B-O
[ X B-O
69,70 NUM B-O
] PUNCT B-O
. PUNCT B-O

Metabolite NOUN B-O
analysis NOUN B-O
was AUX B-O
conducted VERB B-O
on ADP B-O
a DET B-O
thermal ADJ B-LF
desorption NOUN I-LF
- PUNCT B-O
gas NOUN B-LF
chromatography NOUN I-LF
time NOUN B-O
- PUNCT B-O
of ADP B-O
- PUNCT B-O
flight NOUN B-O
mass NOUN B-O
spectrometer NOUN B-O
( PUNCT B-O
GC PROPN B-AC
- PUNCT B-O
TOF PROPN B-O
- PUNCT B-O
MS PROPN B-O
) PUNCT B-O
platform NOUN B-O
( PUNCT B-O
Unity PROPN B-O
II PROPN B-O
TD PROPN B-AC
with ADP B-O
UltrA PROPN B-O
autosampler NOUN B-O
, PUNCT B-O
Markes PROPN B-O
International PROPN B-O
, PUNCT B-O
and CCONJ B-O
Micromass PROPN B-O
GCT PROPN B-O
Premier PROPN B-O
, PUNCT B-O
Waters PROPN B-O
Corp PROPN B-O
, PUNCT B-O
Manchester PROPN B-O
, PUNCT B-O
UK PROPN B-O
) PUNCT B-O
. PUNCT B-O
Prior ADV B-O
to ADP B-O
desorption NOUN B-O
, PUNCT B-O
100 NUM B-O
μl NOUN B-O
of ADP B-O
an DET B-O
internal ADJ B-LF
standard NOUN I-LF
( PUNCT B-O
IS PROPN B-AC
; PUNCT B-O
1 NUM B-O
ppmV NOUN B-O
4 NUM B-O
- PUNCT B-O
bromofluorobenzene NOUN B-O
in ADP B-O
N2 PROPN B-O
; PUNCT B-O
Thames PROPN B-O
Restek PROPN B-O
, PUNCT B-O
Bucks PROPN B-O
, PUNCT B-O
UK PROPN B-O
) PUNCT B-O
was AUX B-O
loaded VERB B-O
onto ADP B-O
each DET B-O
tube NOUN B-O
. PUNCT B-O

Briefly ADV B-O
, PUNCT B-O
the DET B-O
three NUM B-O
dilutions NOUN B-O
of ADP B-O
Essential PROPN B-LF
Iodine PROPN I-LF
Drops PROPN I-LF
( PUNCT B-O
EID PROPN B-AC
) PUNCT B-O
containing VERB B-O
SARS PROPN B-AC
- PUNCT B-AC
CoV-2 PROPN B-AC
virus NOUN B-O
solution NOUN B-O
( PUNCT B-O
1:1 NUM B-O
; PUNCT B-O
2:1 NUM B-O
and CCONJ B-O
3:1 NUM B-O
) PUNCT B-O
were AUX B-O
tested VERB B-O
in ADP B-O
triplicates NOUN B-O
for ADP B-O
virucidal ADJ B-O
activity NOUN B-O
as SCONJ B-O
described VERB B-O
by ADP B-O
Pelletier PROPN B-O
and CCONJ B-O
colleagues NOUN B-O
[ PUNCT B-O
12 NUM B-O
] PUNCT B-O
. PUNCT B-O

Finally ADV B-O
, PUNCT B-O
we PRON B-O
confirmed VERB B-O
the DET B-O
impact NOUN B-O
of ADP B-O
HF PROPN B-AC
diet NOUN B-O
on ADP B-O
striatal ADJ B-O
DA NOUN B-AC
D2 NOUN B-LF
receptor NOUN I-LF
( PUNCT B-O
D2R PROPN B-AC
) PUNCT B-O
availability NOUN B-O
using VERB B-O
[ X B-O
18F]fallypride X B-O
positron NOUN B-LF
emission NOUN I-LF
tomography NOUN I-LF
( PUNCT B-O
PET NOUN B-AC
) PUNCT B-O
. PUNCT B-O

Hospital PROPN B-LF
Based PROPN I-LF
Health PROPN I-LF
Technology PROPN I-LF
Assessment PROPN I-LF
( PUNCT B-O
HB PROPN B-AC
- PUNCT B-AC
HTA PROPN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
new ADJ B-O
policy NOUN B-O
implemented VERB B-O
in ADP B-O
Poland PROPN B-O
to ADP B-O
allow VERB B-O
for ADP B-O
a DET B-O
more ADV B-O
practical ADJ B-O
and CCONJ B-O
contextualized ADJ B-O
assessment NOUN B-O
related VERB B-O
to ADP B-O
the DET B-O
use NOUN B-O
of ADP B-O
specific ADJ B-O
medical ADJ B-O
procedures NOUN B-O
, PUNCT B-O
devices NOUN B-O
, PUNCT B-O
or CCONJ B-O
equipment NOUN B-O
. PUNCT B-O

We PRON B-O
found VERB B-O
that SCONJ B-O
dietary ADJ B-O
intervention NOUN B-O
with ADP B-O
test NOUN B-O
food NOUN B-O
altered VERB B-O
urine NOUN B-O
characteristic ADJ B-O
such ADJ B-O
that SCONJ B-O
the DET B-O
RSS NOUN B-AC
for ADP B-O
struvite NOUN B-O
crystals NOUN B-O
was AUX B-O
decreased VERB B-O
( PUNCT B-O
P NOUN B-O
= SYM B-O
0.03 NUM B-O
) PUNCT B-O
and CCONJ B-O
there PRON B-O
tended VERB B-O
to ADP B-O
be AUX B-O
increased VERB B-O
resistance NOUN B-O
to ADP B-O
oxalate NOUN B-O
crystal NOUN B-O
formation NOUN B-O
as SCONJ B-O
determined VERB B-O
by ADP B-O
the DET B-O
calcium NOUN B-LF
oxalate NOUN I-LF
titrimetric ADJ I-LF
test NOUN I-LF
( PUNCT B-O
COT NOUN B-AC
; PUNCT B-O
P NOUN B-O
= SYM B-O
0.06 NUM B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
model NOUN B-O
was AUX B-O
implemented VERB B-O
by ADP B-O
a DET B-O
set NOUN B-O
of ADP B-O
ordinary ADJ B-LF
differential ADJ I-LF
equations NOUN I-LF
( PUNCT B-O
ODEs NOUN B-AC
) PUNCT B-O
[ X B-O
18 NUM B-O
] PUNCT B-O
, PUNCT B-O
an DET B-O
approach NOUN B-O
successfully ADV B-O
used VERB B-O
to ADP B-O
describe VERB B-O
the DET B-O
cell NOUN B-O
cycle NOUN B-O
control NOUN B-O
in ADP B-O
budding VERB B-O
yeast NOUN B-O
[ X B-O
19,20 NUM B-O
] PUNCT B-O
and CCONJ B-O
the DET B-O
cellular ADJ B-O
response NOUN B-O
of ADP B-O
yeast NOUN B-O
to ADP B-O
hyperosmotic ADJ B-O
shock NOUN B-O
[ X B-O
21 NUM B-O
] PUNCT B-O
. PUNCT B-O

For ADP B-O
daytime NOUN B-O
physical ADJ B-O
activity NOUN B-O
, PUNCT B-O
FSS PROPN B-AC
and CCONJ B-O
sleep NOUN B-O
efficiency NOUN B-O
, PUNCT B-O
the DET B-O
mean NOUN B-O
change NOUN B-O
and CCONJ B-O
the DET B-O
95 NUM B-O
% NOUN B-O
confidence NOUN B-LF
interval NOUN I-LF
( PUNCT B-O
CI NOUN B-AC
) PUNCT B-O
between ADP B-O
baseline NOUN B-O
( PUNCT B-O
Day PROPN B-O
1 NUM B-O
) PUNCT B-O
and CCONJ B-O
Day PROPN B-O
28 NUM B-O
, PUNCT B-O
Day PROPN B-O
84 NUM B-O
and CCONJ B-O
12 NUM B-O
weeks NOUN B-O
post NOUN B-O
- NOUN B-O
treatment NOUN B-O
( PUNCT B-O
Day PROPN B-O
168 NUM B-O
) PUNCT B-O
was AUX B-O
calculated VERB B-O
. PUNCT B-O

Furthermore ADV B-O
, PUNCT B-O
our PRON B-O
cryo NOUN B-LF
- PUNCT I-LF
electron NOUN I-LF
microscopy NOUN I-LF
( PUNCT B-O
cryo NOUN B-AC
- PUNCT B-AC
EM NOUN B-AC
) PUNCT B-O
structure NOUN B-O
of ADP B-O
the DET B-O
50S·ObgE·GMPPNP PROPN B-AC
complex NOUN B-O
indicates VERB B-O
that SCONJ B-O
the DET B-O
evolutionarily ADV B-O
conserved VERB B-O
N NOUN B-LF
- PUNCT I-LF
terminal NOUN I-LF
domain NOUN I-LF
( PUNCT B-O
NTD PROPN B-AC
) PUNCT B-O
of ADP B-O
ObgE PROPN B-AC
is AUX B-O
a DET B-O
tRNA NOUN B-O
structural ADJ B-O
mimic NOUN B-O
, PUNCT B-O
with ADP B-O
specific ADJ B-O
interactions NOUN B-O
with ADP B-O
peptidyl NOUN B-O
- PUNCT B-O
transferase NOUN B-O
center NOUN B-O
, PUNCT B-O
displaying VERB B-O
a DET B-O
marked ADJ B-O
resemblance NOUN B-O
to ADP B-O
Class PROPN B-O
I NUM B-O
release NOUN B-O
factors NOUN B-O
. PUNCT B-O

Cardiovascular ADJ B-O
risk NOUN B-O
factors NOUN B-O
included VERB B-O
BMI NOUN B-O
z NOUN B-O
- PUNCT B-O
score NOUN B-O
, PUNCT B-O
waist NOUN B-O
circumference NOUN B-O
, PUNCT B-O
blood NOUN B-O
pressure NOUN B-O
( PUNCT B-O
z NOUN B-O
- PUNCT B-O
score NOUN B-O
) PUNCT B-O
and CCONJ B-O
estimated VERB B-O
cardiorespiratory ADJ B-LF
fitness NOUN I-LF
( PUNCT B-O
CRF NOUN B-AC
) PUNCT B-O
as SCONJ B-O
measured VERB B-O
with ADP B-O
the DET B-O
20 NUM B-O
meter NOUN B-O
shuttle NOUN B-O
run NOUN B-O
test NOUN B-O
. PUNCT B-O

To ADP B-O
this DET B-O
end NOUN B-O
, PUNCT B-O
we PRON B-O
used VERB B-O
human ADJ B-O
functional ADJ B-LF
magnetic ADJ I-LF
resonance NOUN I-LF
imaging NOUN I-LF
( PUNCT B-O
fMRI NOUN B-AC
) PUNCT B-O
combined VERB B-O
with ADP B-O
psychophysics NOUN B-O
. PUNCT B-O

Sensitivity NOUN B-O
of ADP B-O
qPCR NOUN B-AC
was AUX B-O
approximately ADV B-O
82 NUM B-O
% PUNCT B-O
and CCONJ B-O
Negative ADJ B-LF
Predictive ADJ I-LF
Value NOUN I-LF
( PUNCT B-O
NPV PROPN B-AC
) PUNCT B-O
79 NUM B-O
% PUNCT B-O
. PUNCT B-O

The DET B-O
lipid NOUN B-O
content NOUN B-O
may AUX B-O
vary VERB B-O
from ADP B-O
1 NUM B-O
to ADP B-O
40 NUM B-O
% NOUN B-O
of ADP B-O
dry ADJ B-LF
matter NOUN I-LF
( PUNCT B-O
DM NOUN B-AC
) PUNCT B-O
in ADP B-O
certain ADJ B-O
strains NOUN B-O
, PUNCT B-O
and CCONJ B-O
under ADP B-O
special ADJ B-O
culture NOUN B-O
conditions NOUN B-O
the DET B-O
level NOUN B-O
can AUX B-O
go VERB B-O
up ADP B-O
to ADP B-O
85 NUM B-O
% NOUN B-O
[ PUNCT B-O
5 NUM B-O
] PUNCT B-O
. PUNCT B-O

Here ADV B-O
, PUNCT B-O
we PRON B-O
reconstituted VERB B-O
the DET B-O
interaction NOUN B-O
of ADP B-O
Atg11 PROPN B-O
with ADP B-O
Atg9 NOUN B-LF
- PUNCT I-LF
proteoliposomes NOUN I-LF
( PUNCT B-O
Atg9 NOUN B-AC
- PUNCT B-AC
PLs NOUN B-O
) PUNCT B-O
from ADP B-O
purified VERB B-O
components NOUN B-O
on ADP B-O
model NOUN B-O
membranes NOUN B-O
in ADP B-O
vitro ADJ B-O
. PUNCT B-O

EHR PROPN B-AC
, PUNCT B-O
electronic ADJ B-LF
health NOUN I-LF
record NOUN I-LF
; PUNCT B-O
LDL NOUN B-AC
- PUNCT B-AC
C PROPN B-AC
, PUNCT B-O
low ADJ B-LF
- PUNCT I-LF
density NOUN I-LF
lipoprotein NOUN I-LF
cholesterol NOUN I-LF
. PUNCT B-O

Similar ADJ B-O
structures NOUN B-O
, PUNCT B-O
including VERB B-O
peroxisome NOUN B-O
- PUNCT B-O
localized VERB B-O
Rab5B PROPN B-O
- PUNCT B-O
containing VERB B-O
membranes NOUN B-O
, PUNCT B-O
were AUX B-O
visible ADJ B-O
when SCONJ B-O
N. PROPN B-O
benthamiana PROPN B-O
plants NOUN B-O
were AUX B-O
infected VERB B-O
with ADP B-O
Cucumber PROPN B-LF
necrosis NOUN I-LF
virus NOUN I-LF
( PUNCT B-O
CNV PROPN B-AC
, PUNCT B-O
a DET B-O
very ADV B-O
close ADJ B-O
relative NOUN B-O
of ADP B-O
TBSV PROPN B-AC
) PUNCT B-O
( PUNCT B-O
Fig PROPN B-O
2B NUM B-O
) PUNCT B-O
. PUNCT B-O
As SCONJ B-O
expected VERB B-O
, PUNCT B-O
uninfected ADJ B-O
N. PROPN B-O
benthamiana PROPN B-O
plants NOUN B-O
did AUX B-O
not PART B-O
show VERB B-O
co NOUN B-O
- PUNCT B-O
localization NOUN B-O
of ADP B-O
the DET B-O
peroxisomal ADJ B-O
GFP PROPN B-AC
- PUNCT B-O
SKL PROPN B-O
and CCONJ B-O
the DET B-O
early ADJ B-O
endosomal ADJ B-O
AtRab5b PROPN B-O
and CCONJ B-O
also ADV B-O
lacked VERB B-O
aggregated VERB B-O
peroxisomes NOUN B-O
( PUNCT B-O
Fig PROPN B-O
2B NUM B-O
, PUNCT B-O
the DET B-O
lowest ADJ B-O
panel NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
human ADJ B-LF
umbilical ADJ I-LF
vein NOUN I-LF
endothelial ADJ I-LF
cells NOUN I-LF
( PUNCT B-O
HUVEC PROPN B-AC
) PUNCT B-O
used VERB B-O
in ADP B-O
the DET B-O
adhesion NOUN B-O
studies NOUN B-O
were AUX B-O
harvested VERB B-O
from ADP B-O
umbilical ADJ B-O
cords NOUN B-O
by ADP B-O
treating VERB B-O
them PRON B-O
with ADP B-O
collagenase NOUN B-O
. PUNCT B-O

The DET B-O
other ADJ B-O
measured VERB B-O
plasma NOUN B-O
interleukins NOUN B-LF
( PUNCT B-O
IL-2 NOUN B-AC
, PUNCT B-O
IL-5 NOUN B-AC
, PUNCT B-O
IL-6 NOUN B-AC
, PUNCT B-O
IL-10 NOUN B-AC
, PUNCT B-O
IL-13 NOUN B-AC
, PUNCT B-O
IL-21 NOUN B-AC
, PUNCT B-O
IL-22 NOUN B-AC
, PUNCT B-O
IL-27 NOUN B-AC
, PUNCT B-O
INF NOUN B-O
- PUNCT B-O
γ NOUN B-O
or CCONJ B-O
TNF NOUN B-AC
- PUNCT B-O
α NOUN B-O
) PUNCT B-O
were AUX B-O
all PRON B-O
similar ADJ B-O
in ADP B-O
Rgp44 NOUN B-O
- PUNCT B-O
immunized VERB B-O
mice NOUN B-O
compared VERB B-O
to ADP B-O
the DET B-O
saline ADJ B-O
group NOUN B-O
. PUNCT B-O

SR NOUN B-AC
- PUNCT B-AC
μCT NOUN B-AC
, PUNCT B-O
synchrotron NOUN B-LF
radiation NOUN I-LF
microcomputed VERB I-LF
tomography NOUN I-LF

The DET B-O
average NOUN B-O
of ADP B-O
three NUM B-O
cardiac ADJ B-O
cycles NOUN B-O
was AUX B-O
used VERB B-O
for ADP B-O
measurements NOUN B-O
of ADP B-O
cardiac ADJ B-O
dimensions NOUN B-O
, PUNCT B-O
and CCONJ B-O
left VERB B-LF
ventricular ADJ I-LF
ejection NOUN I-LF
fraction NOUN I-LF
( PUNCT B-O
LVEF PROPN B-AC
) PUNCT B-O
. PUNCT B-O

Significance NOUN B-O
was AUX B-O
determined VERB B-O
by ADP B-O
one NUM B-O
- PUNCT B-O
way NOUN B-O
ANOVA NOUN B-O
with ADP B-O
Tukey PROPN B-O
- PUNCT B-O
Kramer PROPN B-O
post NOUN B-O
- PUNCT B-O
test NOUN B-O
. PUNCT B-O
* PUNCT B-O
represents VERB B-O
p NOUN B-O
≤ ADP B-O
0.05 NUM B-O
; PUNCT B-O
* PUNCT B-O
* PUNCT B-O
represents VERB B-O
p NOUN B-O
≤ ADP B-O
0.01 NUM B-O
. PUNCT B-O
( PUNCT B-O
F NOUN B-O
) PUNCT B-O
Projection NOUN B-O
of ADP B-O
signaling NOUN B-O
data NOUN B-O
from ADP B-O
vehicle- NOUN B-O
and CCONJ B-O
rapamycin NOUN B-O
- PUNCT B-O
treated VERB B-O
samples NOUN B-O
onto ADP B-O
a DET B-O
partial ADJ B-LF
least ADJ I-LF
squares NOUN I-LF
regression NOUN I-LF
( PUNCT B-O
PLSR PROPN B-AC
) PUNCT B-O
model NOUN B-O
built VERB B-O
from ADP B-O
untreated ADJ B-O
samples NOUN B-O
. PUNCT B-O

For ADP B-O
the DET B-O
molecular ADJ B-O
analysis NOUN B-O
at ADP B-O
the DET B-O
Hlx1 NOUN B-O
hotspot NOUN B-O
, PUNCT B-O
mice NOUN B-O
heterozygous ADJ B-O
for ADP B-O
the DET B-O
B10 PROPN B-O
and CCONJ B-O
CAST PROPN B-O
alleles NOUN B-O
at ADP B-O
the DET B-O
chromosome NOUN B-LF
1 NUM B-O
Hlx1 NOUN B-O
hotspot NOUN B-O
and CCONJ B-O
carrying VERB B-O
the DET B-O
appropriate ADJ B-O
genotype NOUN B-O
on ADP B-O
Chr PROPN B-AC
17 NUM B-O
have AUX B-O
been AUX B-O
generated VERB B-O
as SCONJ B-O
follows VERB B-O
: PUNCT B-O
CASTxR209 PROPN B-O
F1 PROPN B-O
hybrids NOUN B-O
were AUX B-O
generated VERB B-O
and CCONJ B-O
crossed VERB B-O
with ADP B-O
B10 PROPN B-O
. PUNCT B-O

Dox PROPN B-AC
, PUNCT B-O
doxycycline NOUN B-LF
; PUNCT B-O
LATS1 PROPN B-AC
, PUNCT B-O
large ADJ B-LF
tumor NOUN I-LF
suppressor NOUN I-LF
kinase NOUN I-LF
1 NUM I-LF
; PUNCT B-O
MST1 PROPN B-AC
, PUNCT B-O
mammalian ADJ B-LF
sterile ADJ I-LF
20 NUM I-LF
- PUNCT I-LF
like ADJ I-LF
kinase NOUN I-LF
1 NUM I-LF
; PUNCT B-O
PPM1A PROPN B-AC
, PUNCT B-O
protein NOUN B-LF
phosphatase NOUN I-LF
magnesium NOUN I-LF
- PUNCT I-LF
dependent ADJ I-LF
1A NOUN I-LF
; PUNCT B-O
TAZ PROPN B-AC
, PUNCT B-O
transcriptional ADJ B-LF
coactivator NOUN I-LF
with ADP I-LF
PDZ NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
motif NOUN I-LF
; PUNCT B-O
TEAD PROPN B-AC
, PUNCT B-O
transcriptional ADJ B-LF
enhanced ADJ I-LF
associate NOUN I-LF
domain NOUN I-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
; PUNCT B-O
YAP PROPN B-AC
, PUNCT B-O
Yes NOUN B-LF
- PUNCT I-LF
associated VERB I-LF
protein NOUN I-LF
. PUNCT B-O

At ADP B-O
E19 PROPN B-O
, PUNCT B-O
birth NOUN B-O
weight NOUN B-O
, PUNCT B-O
lung NOUN B-O
weight NOUN B-O
and CCONJ B-O
lung NOUN B-LF
weight NOUN I-LF
/ SYM I-LF
birth NOUN I-LF
weight NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
LW NOUN B-AC
/ SYM B-AC
BW NOUN B-AC
ratio NOUN B-AC
) PUNCT B-O
were AUX B-O
significantly ADV B-O
lower ADJ B-O
in ADP B-O
the DET B-O
pups NOUN B-O
born VERB B-O
of ADP B-O
VDL PROPN B-AC
mothers NOUN B-O
than ADP B-O
in ADP B-O
the DET B-O
controls NOUN B-O
. PUNCT B-O

The DET B-O
Intra ADJ B-O
- ADJ B-O
class NOUN B-O
Correlation NOUN B-O
Coefficient NOUN B-O
( PUNCT B-O
ICC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Median ADJ B-LF
Odds NOUN I-LF
Ratio NOUN I-LF
( PUNCT B-O
MOR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Proportional ADJ B-LF
Change NOUN I-LF
in ADP I-LF
Variance NOUN I-LF
( PUNCT B-O
PCV PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
deviance NOUN B-O
( PUNCT B-O
-2LL NOUN B-O
) PUNCT B-O
were AUX B-O
used VERB B-O
for ADP B-O
model NOUN B-O
comparison NOUN B-O
and CCONJ B-O
for ADP B-O
checking VERB B-O
model NOUN B-O
fitness NOUN B-O
. PUNCT B-O

We PRON B-O
show VERB B-O
that SCONJ B-O
amino ADJ B-O
- PUNCT B-O
terminal ADJ B-O
tripeptides NOUN B-O
of ADP B-O
several ADJ B-O
secreted VERB B-O
proteins NOUN B-O
bind VERB B-O
to ADP B-O
transmembrane NOUN B-O
cargo NOUN B-O
receptor NOUN B-O
, PUNCT B-O
surfeit NOUN B-LF
locus NOUN I-LF
protein NOUN I-LF
4 NUM I-LF
( PUNCT B-O
Surf4 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
for ADP B-O
increased VERB B-O
ER NOUN B-AC
- PUNCT B-O
trafficking NOUN B-O
efficiency NOUN B-O
. PUNCT B-O

We PRON B-O
identified VERB B-O
and CCONJ B-O
excluded VERB B-O
women NOUN B-O
with ADP B-O
prior ADJ B-O
CKD PROPN B-AC
, PUNCT B-O
CVD PROPN B-AC
, PUNCT B-O
hypertension NOUN B-O
, PUNCT B-O
or CCONJ B-O
diabetes NOUN B-O
through ADP B-O
a DET B-O
linkage NOUN B-O
with ADP B-O
the DET B-O
NPR PROPN B-AC
using VERB B-O
the DET B-O
international ADJ B-LF
classification NOUN I-LF
of ADP I-LF
diseases NOUN I-LF
( PUNCT B-O
ICD PROPN B-AC
) PUNCT B-O
codes NOUN B-O
( PUNCT B-O
S1 PROPN B-O
Table PROPN B-O
) PUNCT B-O
. PUNCT B-O

We PRON B-O
next ADV B-O
conducted VERB B-O
an DET B-O
unbiased ADJ B-O
, PUNCT B-O
data NOUN B-O
- PUNCT B-O
driven VERB B-O
analysis NOUN B-O
to ADP B-O
prioritize VERB B-O
damaging ADJ B-O
variants NOUN B-O
most ADV B-O
likely ADJ B-O
to ADP B-O
contribute VERB B-O
to ADP B-O
the DET B-O
risk NOUN B-O
of ADP B-O
developing VERB B-O
an DET B-O
ED NOUN B-AC
. PUNCT B-O
First ADV B-O
, PUNCT B-O
we PRON B-O
identified VERB B-O
all DET B-O
genes NOUN B-O
mentioned VERB B-O
in ADP B-O
three NUM B-O
or CCONJ B-O
more ADJ B-O
papers NOUN B-O
in ADP B-O
the DET B-O
PubMed PROPN B-O
database NOUN B-O
that PRON B-O
mention VERB B-O
either CCONJ B-O
" PUNCT B-O
appetite NOUN B-O
" PUNCT B-O
or CCONJ B-O
" PUNCT B-O
eating NOUN B-LF
disorder NOUN I-LF
" PUNCT B-O
( PUNCT B-O
S2 PROPN B-O
Table NOUN B-O
) PUNCT B-O
. PUNCT B-O

DALY PROPN B-AC
, PUNCT B-O
disability NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
year NOUN I-LF
; PUNCT B-O
GBD PROPN B-AC
, PUNCT B-O
Global PROPN B-LF
Burden PROPN I-LF
of ADP I-LF
Disease PROPN I-LF
Study PROPN I-LF
. PUNCT B-O

Analyses NOUN B-O
were AUX B-O
carried VERB B-O
out ADP B-O
for ADP B-O
all DET B-O
participants NOUN B-O
randomised VERB B-O
to ADP B-O
the DET B-O
study NOUN B-O
( PUNCT B-O
ITT NOUN B-AC
set NOUN B-O
, PUNCT B-O
n NOUN B-O
= SYM B-O
573 NUM B-O
) PUNCT B-O
and CCONJ B-O
for ADP B-O
the DET B-O
per ADP B-LF
protocol NOUN I-LF
set NOUN I-LF
( PUNCT B-O
PPS NOUN B-AC
, PUNCT B-O
n NOUN B-O
= SYM B-O
331 NUM B-O
) PUNCT B-O
. PUNCT B-O

In ADP B-O
a DET B-O
cover NOUN B-LF
crop NOUN I-LF
( PUNCT B-O
CC PROPN B-AC
) PUNCT B-O
experiment NOUN B-O
established VERB B-O
in ADP B-O
2007 NUM B-O
and CCONJ B-O
repeated VERB B-O
at ADP B-O
an DET B-O
adjacent ADJ B-O
site NOUN B-O
in ADP B-O
2008 NUM B-O
, PUNCT B-O
we PRON B-O
evaluated VERB B-O
the DET B-O
medium ADJ B-O
- PUNCT B-O
term NOUN B-O
impact NOUN B-O
of ADP B-O
CC PROPN B-AC
( PUNCT B-O
no DET B-LF
cover NOUN I-LF
crop NOUN I-LF
control NOUN I-LF
( PUNCT B-O
no DET B-AC
- PUNCT B-AC
CC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
oat NOUN B-O
( PUNCT B-O
Avena PROPN B-O
sativa PROPN B-O
L. PROPN B-O
) PUNCT B-O
, PUNCT B-O
oilseed NOUN B-LF
radish NOUN I-LF
( PUNCT B-O
OSR PROPN B-AC
, PUNCT B-O
Raphanus PROPN B-O
sativus PROPN B-O
L. PROPN B-O
var NOUN B-O
. PUNCT B-O
oleoferus PROPN B-O
Metzg PROPN B-O
. PUNCT B-O

SD NOUN B-AC
, PUNCT B-O
standard ADJ B-LF
deviation NOUN I-LF

DRS PROPN B-AC
, PUNCT B-O
Durham PROPN B-LF
Risk NOUN I-LF
Score NOUN I-LF
. PUNCT B-O

APC PROPN B-AC
, PUNCT B-O
antigen NOUN B-LF
- PUNCT I-LF
presenting VERB I-LF
cell NOUN I-LF
; PUNCT B-O
CNS PROPN B-AC
, PUNCT B-O
central ADJ B-LF
nervous ADJ I-LF
system NOUN I-LF
; PUNCT B-O
DO PROPN B-AC
, PUNCT B-O
H2 NOUN B-O
- PUNCT B-O
O NOUN B-O
; PUNCT B-O
KO PROPN B-AC
, PUNCT B-O
knockout NOUN B-LF
; PUNCT B-O
MOG PROPN B-AC
, PUNCT B-O
myelin NOUN B-LF
oligodendrocyte NOUN I-LF
glycoprotein NOUN I-LF
. PUNCT B-O

International PROPN B-O
funding NOUN B-O
, PUNCT B-O
including VERB B-O
that PRON B-O
from ADP B-O
governments NOUN B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
from ADP B-O
PMI PROPN B-AC
, PUNCT B-O
the DET B-O
United PROPN B-O
Kingdom PROPN B-O
’s PART B-O
Department PROPN B-LF
for ADP I-LF
International PROPN I-LF
Development PROPN I-LF
( PUNCT B-O
DFID PROPN B-AC
) PUNCT B-O
, PUNCT B-O
the DET B-O
Global PROPN B-O
Fund PROPN B-O
, PUNCT B-O
and CCONJ B-O
others NOUN B-O
, PUNCT B-O
accounts VERB B-O
for ADP B-O
a DET B-O
large ADJ B-O
proportion NOUN B-O
( PUNCT B-O
approximately ADV B-O
68 NUM B-O
% NOUN B-O
[ NUM B-O
5 NUM B-O
] PUNCT B-O
) PUNCT B-O
of ADP B-O
the DET B-O
funds NOUN B-O
available ADJ B-O
for ADP B-O
malaria NOUN B-O
control NOUN B-O
worldwide ADV B-O
. PUNCT B-O

During ADP B-O
chemotropic ADJ B-O
interactions NOUN B-O
, PUNCT B-O
the DET B-O
mitogen NOUN B-LF
- PUNCT I-LF
activated VERB I-LF
protein NOUN I-LF
kinase NOUN I-LF
( PUNCT B-O
MAPK PROPN B-AC
) PUNCT B-O
signal NOUN B-O
transduction NOUN B-O
protein NOUN B-O
complex NOUN B-O
( PUNCT B-O
NRC-1 PROPN B-O
, PUNCT B-O
MEK-2 PROPN B-O
, PUNCT B-O
MAK-2 PROPN B-O
, PUNCT B-O
and CCONJ B-O
the DET B-O
scaffold NOUN B-O
protein NOUN B-O
HAM-5 PROPN B-O
) PUNCT B-O
assembles VERB B-O
/ SYM B-O
disassembles VERB B-O
at ADP B-O
the DET B-O
CAT PROPN B-AC
tip NOUN B-O
of ADP B-O
communicating VERB B-O
germlings NOUN B-O
with ADP B-O
perfectly ADV B-O
out ADP B-O
of ADP B-O
phase NOUN B-O
dynamics NOUN B-O
to ADP B-O
SOFT PROPN B-O
, PUNCT B-O
a DET B-O
scaffold NOUN B-O
protein NOUN B-O
for ADP B-O
components NOUN B-O
of ADP B-O
the DET B-O
MAPK PROPN B-AC
cell NOUN B-O
wall NOUN B-O
integrity NOUN B-O
pathway NOUN B-O
[ PUNCT B-O
44–48 NUM B-O
] PUNCT B-O
. PUNCT B-O

Incidence NOUN B-LF
rate NOUN I-LF
ratios NOUN I-LF
( PUNCT B-O
IRRs NOUN B-AC
) PUNCT B-O
adjusted VERB B-O
for ADP B-O
placental ADJ B-O
malaria NOUN B-O
infection NOUN B-O
and CCONJ B-O
individual ADJ B-O
malaria NOUN B-O
exposure NOUN B-O
. PUNCT B-O

I.P. NOUN B-O
, PUNCT B-O
intraperitoneal ADJ B-O
; PUNCT B-O
LEC PROPN B-AC
, PUNCT B-O
lateral ADJ B-LF
entorhinal ADJ I-LF
cortex NOUN I-LF
; PUNCT B-O
LFP PROPN B-AC
, PUNCT B-O
local ADJ B-LF
field NOUN I-LF
potential NOUN I-LF
; PUNCT B-O
MUA NOUN B-AC
, PUNCT B-O
multiunit NOUN B-LF
activity NOUN I-LF
; PUNCT B-O
OB NOUN B-AC
, PUNCT B-O
olfactory ADJ B-LF
bulb NOUN I-LF
; PUNCT B-O
RR NOUN B-AC
, PUNCT B-O
respiration NOUN B-LF
- PUNCT I-LF
related VERB I-LF
rhythm NOUN I-LF
. PUNCT B-O

With ADP B-O
the DET B-O
addition NOUN B-O
of ADP B-O
utilities NOUN B-O
, PUNCT B-O
the DET B-O
immediate ADJ B-O
cystectomy NOUN B-O
strategy NOUN B-O
yielded VERB B-O
an DET B-O
average ADJ B-O
QALE NOUN B-AC
of ADP B-O
12.32 NUM B-O
y NOUN B-O
and CCONJ B-O
remained VERB B-O
preferred ADJ B-O
over ADP B-O
conservative ADJ B-O
therapy NOUN B-O
by ADP B-O
0.35 NUM B-O
QALY PROPN B-AC
( PUNCT B-O
quality NOUN B-LF
- PUNCT I-LF
adjusted VERB I-LF
life NOUN I-LF
years NOUN I-LF
) PUNCT B-O
. PUNCT B-O

ART PROPN B-AC
, PUNCT B-O
antiretroviral ADJ B-LF
therapy NOUN I-LF
; PUNCT B-O
cART PROPN B-AC
, PUNCT B-O
combination NOUN B-LF
antiretroviral ADJ I-LF
therapy NOUN I-LF
; PUNCT B-O
EE&T PROPN B-AC
, PUNCT B-O
Eastern PROPN B-LF
Europe PROPN I-LF
and CCONJ I-LF
Thailand PROPN I-LF
; PUNCT B-O
W&CE PROPN B-AC
, PUNCT B-O
Western PROPN B-LF
and CCONJ I-LF
Central PROPN I-LF
Europe PROPN I-LF
. PUNCT B-O

In ADP B-O
a DET B-O
recent ADJ B-O
local ADJ B-O
study NOUN B-O
among ADP B-O
mental ADJ B-O
health NOUN B-O
professionals NOUN B-O
working VERB B-O
at ADP B-O
the DET B-O
Institute PROPN B-LF
of ADP I-LF
Mental PROPN I-LF
Health PROPN I-LF
( PUNCT B-O
IMH PROPN B-AC
) PUNCT B-O
, PUNCT B-O
Yang PROPN B-O
et PROPN B-O
al NOUN B-O
[ X B-O
23 NUM B-O
] X B-O
similarly ADV B-O
found VERB B-O
staff NOUN B-O
were AUX B-O
experiencing VERB B-O
high ADJ B-O
levels NOUN B-O
of ADP B-O
stress NOUN B-O
and CCONJ B-O
burnout NOUN B-O
. PUNCT B-O

In ADP B-O
a DET B-O
previous ADJ B-O
study NOUN B-O
we PRON B-O
described VERB B-O
how SCONJ B-O
RSV PROPN B-AC
, PUNCT B-O
as ADP B-O
well ADV B-O
as ADP B-O
certain ADJ B-O
metabolites NOUN B-O
( PUNCT B-O
trans NOUN B-LF
- NOUN I-LF
resveratrol-3 NOUN I-LF
- NOUN I-LF
O NOUN I-LF
- NOUN I-LF
sulfate NOUN I-LF
-3S- NOUN B-AC
, PUNCT B-O
trans NOUN B-LF
- NOUN I-LF
resveratrol-3'-O NOUN I-LF
- NOUN B-O
glucuronide NOUN B-O
-3G- NOUN B-AC
and CCONJ B-O
trans NOUN B-LF
- NOUN I-LF
resveratrol-4'-O NOUN I-LF
- NOUN B-O
glucuronide NOUN B-O
-4G- NOUN B-AC
) PUNCT B-O
were AUX B-O
able ADJ B-O
to ADP B-O
modify VERB B-O
the DET B-O
expression NOUN B-O
of ADP B-O
genes NOUN B-O
related VERB B-O
to ADP B-O
the DET B-O
adipogenic ADJ B-O
process NOUN B-O
[ PUNCT B-O
25 NUM B-O
] PUNCT B-O
. PUNCT B-O

Therefore ADV B-O
, PUNCT B-O
we PRON B-O
serially ADV B-O
passaged VERB B-O
HPV18 PROPN B-O
wild ADJ B-LF
- PUNCT I-LF
type NOUN I-LF
( PUNCT B-O
WT)- NOUN B-AC
and CCONJ B-O
ΔCTCF NOUN B-O
- PUNCT B-O
genome NOUN B-O
– PUNCT B-O
containing VERB B-O
human ADJ B-LF
foreskin NOUN I-LF
keratinocytes NOUN I-LF
( PUNCT B-O
HFKs PROPN B-AC
) PUNCT B-O
and CCONJ B-O
performed VERB B-O
Southern ADJ B-O
blot NOUN B-O
analysis NOUN B-O
to PART B-O
examine VERB B-O
HPV18 PROPN B-O
episome NOUN B-O
copy NOUN B-O
- PUNCT B-O
number NOUN B-O
variation NOUN B-O
over ADP B-O
time NOUN B-O
. PUNCT B-O

The DET B-O
radical ADJ B-O
scavenging NOUN B-O
ability NOUN B-O
of ADP B-O
oils NOUN B-O
investigated VERB B-O
by ADP B-O
2,2 NUM B-LF
- PUNCT I-LF
diphenyl-1 NOUN I-LF
- PUNCT I-LF
picrylhydrazyl NOUN I-LF
( PUNCT B-O
DPPH PROPN B-AC
) PUNCT B-O
assay NOUN B-O
revealed VERB B-O
that SCONJ B-O
the DET B-O
IC50 PROPN B-O
value NOUN B-O
of ADP B-O
GCO PROPN B-AC
was AUX B-O
significantly ADV B-O
lower ADJ B-O
than ADP B-O
of ADP B-O
RCO PROPN B-AC
( PUNCT B-O
p<0.05 NUM B-O
) PUNCT B-O
. PUNCT B-O

Decreases NOUN B-O
in ADP B-O
trabecular ADJ B-O
, PUNCT B-O
but CCONJ B-O
not PART B-O
cortical ADJ B-O
, PUNCT B-O
bone NOUN B-O
volumes NOUN B-O
over ADP B-O
total ADJ B-O
volumes NOUN B-O
( PUNCT B-O
BV NOUN B-AC
/ SYM B-AC
TV NOUN B-AC
) PUNCT B-O
, PUNCT B-O
trabecular ADJ B-LF
bone NOUN I-LF
number NOUN I-LF
( PUNCT B-O
Tb NOUN B-AC
. PUNCT B-AC
N NOUN B-AC
) PUNCT B-O
, PUNCT B-O
trabecular ADJ B-O
bone NOUN B-O
thickness NOUN B-O
, PUNCT B-O
and CCONJ B-O
increase NOUN B-O
in ADP B-O
trabecular ADJ B-LF
bone NOUN I-LF
space NOUN I-LF
( PUNCT B-O
Tb NOUN B-AC
. PUNCT B-AC
Sp PROPN B-AC
) PUNCT B-O
were AUX B-O
all PRON B-O
detected VERB B-O
in ADP B-O
LmnaHSA PROPN B-AC
- PUNCT B-AC
cko NOUN B-AC
mice NOUN B-O
as SCONJ B-O
compared VERB B-O
with ADP B-O
those PRON B-O
of ADP B-O
littermate NOUN B-O
controls NOUN B-O
( PUNCT B-O
Fig NOUN B-O
2 NUM B-O
G NOUN B-O
and CCONJ B-O
2H NOUN B-O
) PUNCT B-O
( PUNCT B-O
S3D NOUN B-O
and CCONJ B-O
S3E PROPN B-O
Fig NOUN B-O
) PUNCT B-O
. PUNCT B-O

There PRON B-O
were VERB B-O
4 NUM B-O
trials NOUN B-O
conducted VERB B-O
in ADP B-O
East PROPN B-O
Asia PROPN B-O
( PUNCT B-O
1 NUM B-O
Chinese ADJ B-O
and CCONJ B-O
3 NUM B-O
Japanese PROPN B-O
) PUNCT B-O
and CCONJ B-O
5 NUM B-O
trials NOUN B-O
outside ADP B-O
Asia PROPN B-O
: PUNCT B-O
Acarbose PROPN B-LF
Cardiovascular PROPN I-LF
Evaluation PROPN I-LF
( PUNCT B-O
ACE PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
22 NUM B-O
] PUNCT B-O
, PUNCT B-O
Action PROPN B-LF
to PART I-LF
Control VERB I-LF
Cardiovascular PROPN I-LF
Risk PROPN I-LF
in ADP I-LF
Diabetes PROPN I-LF
( PUNCT B-O
ACCORD PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
23 NUM B-O
] PUNCT B-O
, PUNCT B-O
Action PROPN B-LF
in ADP I-LF
Diabetes PROPN I-LF
and CCONJ I-LF
Vascular ADJ I-LF
disease NOUN I-LF
: PUNCT I-LF
preterAx NOUN I-LF
and CCONJ I-LF
diamicroN ADJ I-LF
- PROPN I-LF
MR NOUN I-LF
Controlled PROPN I-LF
Evaluation PROPN I-LF
( PUNCT B-O
ADVANCE PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
24 NUM B-O
] PUNCT B-O
, PUNCT B-O
Diabetes PROPN B-LF
Prevention PROPN I-LF
Program PROPN I-LF
( PUNCT B-O
DPP PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
25 NUM B-O
] PUNCT B-O
, PUNCT B-O
Japan PROPN B-LF
Diabetes PROPN I-LF
Complications PROPN I-LF
Study PROPN I-LF
( PUNCT B-O
JDCS PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
26 NUM B-O
] PUNCT B-O
, PUNCT B-O
Japan PROPN B-LF
Elderly PROPN I-LF
Diabetes PROPN I-LF
Intervention PROPN I-LF
Trial PROPN I-LF
( PUNCT B-O
J PROPN B-AC
- PROPN B-AC
EDIT PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
27 NUM B-O
] PUNCT B-O
, PUNCT B-O
Japanese PROPN B-LF
Primary PROPN I-LF
Prevention PROPN I-LF
of ADP I-LF
Atherosclerosis PROPN I-LF
with ADP I-LF
Aspirin PROPN I-LF
for ADP I-LF
Diabetes PROPN I-LF
trial NOUN B-O
( PUNCT B-O
JPAD PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
28 NUM B-O
] PUNCT B-O
, PUNCT B-O
and CCONJ B-O
UK PROPN B-LF
Prospective PROPN I-LF
Diabetes PROPN I-LF
Study PROPN I-LF
33 NUM I-LF
and CCONJ I-LF
80 NUM I-LF
( PUNCT B-O
UKPDS PROPN B-AC
33 NUM B-AC
and CCONJ B-AC
80 NUM B-AC
) PUNCT B-O
[ PUNCT B-O
29,30 NUM B-O
] PUNCT B-O
. PUNCT B-O

8 NUM B-O
- PUNCT B-O
OHdG NOUN B-O
, PUNCT B-O
8 NUM B-O
- PUNCT B-O
hydroxy-2′-deoxyguanosine NOUN B-O
; PUNCT B-O
BPA PROPN B-AC
, PUNCT B-O
bisphenol NOUN B-LF
A NOUN I-LF
; PUNCT B-O
DEHP PROPN B-AC
, PUNCT B-O
di(2 NOUN B-LF
- PUNCT I-LF
ethylhexyl NOUN I-LF
) PUNCT I-LF
phthalate NOUN I-LF
; PUNCT B-O
DOP PROPN B-AC
, PUNCT B-O
di NOUN B-LF
- PUNCT I-LF
n NOUN I-LF
- PUNCT I-LF
octyl NOUN I-LF
phthalate NOUN I-LF
; PUNCT B-O
HMW PROPN B-AC
, PUNCT B-O
high ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
; PUNCT B-O
LMW PROPN B-AC
, PUNCT B-O
low ADJ B-LF
molecular ADJ I-LF
weight NOUN I-LF
; PUNCT B-O
PA PROPN B-AC
, PUNCT B-O
phthalic NOUN B-LF
acid NOUN I-LF
. PUNCT B-O

Bcat2 NOUN B-O
, PUNCT B-O
β NOUN B-O
- NOUN B-O
catenin-2 NOUN B-O
; PUNCT B-O
RNAi NOUN B-AC
, PUNCT B-O
RNA NOUN B-LF
interference NOUN I-LF
. PUNCT B-O

We PRON B-O
conducted VERB B-O
a DET B-O
two NUM B-O
- PUNCT B-O
sample NOUN B-O
Mendelian ADJ B-LF
randomization NOUN I-LF
( PUNCT B-O
MR PROPN B-AC
) PUNCT B-O
analysis NOUN B-O
to PART B-O
evaluate VERB B-O
the DET B-O
relationship NOUN B-O
between ADP B-O
coffee NOUN B-O
consumption NOUN B-O
and CCONJ B-O
breast NOUN B-O
cancer NOUN B-O
risk NOUN B-O
using VERB B-O
33 NUM B-O
single ADJ B-LF
- PUNCT I-LF
nucleotide NOUN I-LF
polymorphisms NOUN I-LF
( PUNCT B-O
SNPs PROPN B-AC
) PUNCT B-O
associated VERB B-O
with ADP B-O
coffee NOUN B-O
consumption NOUN B-O
from ADP B-O
a DET B-O
genome NOUN B-LF
- PUNCT I-LF
wide ADJ I-LF
association NOUN I-LF
( PUNCT B-O
GWA PROPN B-AC
) PUNCT B-O
study NOUN B-O
on ADP B-O
212,119 NUM B-O
female ADJ B-O
UK PROPN B-O
Biobank PROPN B-O
participants NOUN B-O
of ADP B-O
White ADJ B-O
British ADJ B-O
ancestry NOUN B-O
. PUNCT B-O

IPW PROPN B-AC
= PUNCT B-O
Inverse ADJ B-LF
Probability NOUN I-LF
Weighting NOUN I-LF

An DET B-O
adaptive ADJ B-O
multi ADJ B-O
- PUNCT B-O
arm ADJ B-O
, PUNCT B-O
2 NUM B-O
- PUNCT B-O
stage NOUN B-O
cluster NOUN B-O
randomised VERB B-O
trial NOUN B-O
was AUX B-O
conducted VERB B-O
between ADP B-O
8 NUM B-O
August PROPN B-O
2016 NUM B-O
and CCONJ B-O
30 NUM B-O
June PROPN B-O
2017 NUM B-O
, PUNCT B-O
with ADP B-O
antenatal ADJ B-LF
care NOUN I-LF
clinic NOUN I-LF
( PUNCT B-O
ANC PROPN B-AC
) PUNCT B-O
days NOUN B-O
( PUNCT B-O
i.e. X B-O
, PUNCT B-O
clusters NOUN B-O
of ADP B-O
women NOUN B-O
attending VERB B-O
on ADP B-O
a DET B-O
single ADJ B-O
day NOUN B-O
) PUNCT B-O
as ADP B-O
the DET B-O
unit NOUN B-O
of ADP B-O
randomisation NOUN B-O
. PUNCT B-O

Peptide NOUN B-O
composition NOUN B-O
was AUX B-O
refined VERB B-O
using VERB B-O
database NOUN B-LF
2 NUM B-O
( PUNCT B-O
db-2 NOUN B-AC
) PUNCT B-O
( PUNCT B-O
unpublished ADJ B-O
data NOUN B-O
) PUNCT B-O
. PUNCT B-O

To PART B-O
measure VERB B-O
work NOUN B-O
intensity NOUN B-O
or CCONJ B-O
aerobic ADJ B-O
strain NOUN B-O
, PUNCT B-O
the DET B-O
recording NOUN B-O
of ADP B-O
heart NOUN B-LF
rate NOUN I-LF
( PUNCT B-O
HR NOUN B-AC
) PUNCT B-O
is AUX B-O
a DET B-O
valid ADJ B-O
method NOUN B-O
. PUNCT B-O

Upon SCONJ B-O
ABA PROPN B-AC
perception NOUN B-O
, PUNCT B-O
the DET B-O
soluble ADJ B-O
ABA PROPN B-AC
receptors NOUN B-O
interact VERB B-O
with ADP B-O
and CCONJ B-O
inhibit VERB B-O
clade NOUN B-O
- PUNCT B-O
A NOUN B-O
protein NOUN B-LF
phosphatase NOUN I-LF
2Cs NOUN I-LF
( PUNCT B-O
PP2Cs NOUN B-AC
): PUNCT B-O
ABA PROPN B-LF
- PUNCT I-LF
insensitive ADJ I-LF
1 NUM I-LF
( PUNCT B-O
ABI1 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
ABA PROPN B-LF
- PUNCT I-LF
insensitive ADJ I-LF
2 NUM I-LF
( PUNCT B-O
ABI2 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
hypersensitive ADJ B-LF
to ADP I-LF
ABA PROPN I-LF
1 NUM I-LF
( PUNCT B-O
HAB1 PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
protein NOUN B-LF
phosphatase NOUN I-LF
2CA NUM I-LF
( PUNCT B-O
PP2CA PROPN B-AC
) PUNCT B-O
; PUNCT B-O
this DET B-O
interaction NOUN B-O
relieves VERB B-O
inhibition NOUN B-O
of ADP B-O
the DET B-O
serine NOUN B-O
- PUNCT B-O
threonine NOUN B-O
kinase NOUN B-O
OPEN PROPN B-LF
STOMATA PROPN I-LF
1 NUM I-LF
( PUNCT B-O
OST1 PROPN B-AC
) PUNCT B-O
[ PUNCT B-O
24 NUM B-O
] PUNCT B-O
. PUNCT B-O

CI NOUN B-AC
= PUNCT B-O
confidence NOUN B-LF
interval NOUN I-LF
, PUNCT B-O
Q1 NOUN B-AC
- PUNCT B-AC
Q3 NOUN B-AC
= PUNCT B-O
Quartile NOUN B-LF
1 NUM I-LF
– PUNCT I-LF
Quartile NOUN I-LF
3 NUM I-LF

We PRON B-O
explore VERB B-O
whether SCONJ B-O
the DET B-O
‘ PUNCT B-O
Auditory PROPN B-LF
Stroop PROPN I-LF
Task PROPN I-LF
’ PUNCT B-O
( PUNCT B-O
AST PROPN B-AC
) PUNCT B-O
can AUX B-O
be AUX B-O
used VERB B-O
to PART B-O
increase VERB B-O
cognitive ADJ B-O
load NOUN B-O
( PUNCT B-O
and CCONJ B-O
thereby ADV B-O
elicit VERB B-O
FOG NOUN B-AC
) PUNCT B-O
, PUNCT B-O
simultaneously ADV B-O
with ADP B-O
visual ADJ B-O
cues NOUN B-O
( PUNCT B-O
as ADP B-O
a DET B-O
therapeutic ADJ B-O
intervention NOUN B-O
for ADP B-O
FOG NOUN B-AC
) PUNCT B-O
. PUNCT B-O
We PRON B-O
additionally ADV B-O
examined VERB B-O
how SCONJ B-O
these DET B-O
two NUM B-O
contrasting VERB B-O
effects NOUN B-O
might AUX B-O
interact VERB B-O
in ADP B-O
affecting VERB B-O
gait NOUN B-O
and CCONJ B-O
FOG NOUN B-AC
parameters NOUN B-O
. PUNCT B-O

factor NOUN B-LF
Xa PROPN I-LF

This DET B-O
G1 PROPN B-O
transcriptional ADJ B-O
circuit NOUN B-O
is AUX B-O
analogous ADJ B-O
to ADP B-O
that PRON B-O
defined VERB B-O
in ADP B-O
mammals NOUN B-O
by ADP B-O
the DET B-O
E2F PROPN B-O
family NOUN B-O
of ADP B-O
transcription NOUN B-O
factors NOUN B-O
and CCONJ B-O
the DET B-O
retinoblastoma NOUN B-LF
( PUNCT B-O
Rb PROPN B-AC
) PUNCT B-O
tumor NOUN B-O
suppressor NOUN B-O
protein NOUN B-O
. PUNCT B-O

H3K4me3 NOUN B-AC
, PUNCT B-O
H3 NOUN B-LF
trimethylation NOUN I-LF
of ADP I-LF
lysine NOUN I-LF
residue NOUN I-LF
4 NUM I-LF
. PUNCT B-O

Overexpression NOUN B-O
of ADP B-O
cdk5 PROPN B-AC
( PUNCT B-O
either CCONJ B-O
alone ADV B-O
or CCONJ B-O
with ADP B-O
its PRON B-O
coactivator NOUN B-O
, PUNCT B-O
p35 NOUN B-O
; PUNCT B-O
[ X B-O
23 NUM B-O
] PUNCT B-O
) PUNCT B-O
or CCONJ B-O
inhibition NOUN B-O
with ADP B-O
DNcdk5 PROPN B-O
had VERB B-O
no DET B-O
significant ADJ B-O
effects NOUN B-O
( PUNCT B-O
p NOUN B-O
> SYM B-O
0.2 NUM B-O
) PUNCT B-O
on ADP B-O
the DET B-O
proliferation NOUN B-O
of ADP B-O
adult ADJ B-O
rat NOUN B-O
NPCs NOUN B-AC
( PUNCT B-O
Figure PROPN B-O
1A–1E NUM B-O
) PUNCT B-O
or CCONJ B-O
mouse NOUN B-O
NPCs NOUN B-AC
( PUNCT B-O
unpublished ADJ B-O
data NOUN B-O
) PUNCT B-O
, PUNCT B-O
as SCONJ B-O
measured VERB B-O
by ADP B-O
the DET B-O
number NOUN B-O
of ADP B-O
bromo NOUN B-LF
- PUNCT I-LF
deoxy NOUN I-LF
- PUNCT I-LF
uridine NOUN I-LF
( PUNCT B-O
BrdU)-incorporating VERB B-AC
cells NOUN B-O
after ADP B-O
a DET B-O
1 NUM B-O
- PUNCT B-O
h NOUN B-O
pulse NOUN B-O
. PUNCT B-O

Disturbances NOUN B-O
in ADP B-O
ER PROPN B-AC
homeostasis NOUN B-O
initiate VERB B-O
the DET B-O
unfolded ADJ B-LF
protein NOUN I-LF
response NOUN I-LF
( PUNCT B-O
UPR NOUN B-AC
) PUNCT B-O
implicated VERB B-O
in ADP B-O
the DET B-O
pathogenesis NOUN B-O
of ADP B-O
many ADJ B-O
human ADJ B-O
diseases NOUN B-O
. PUNCT B-O

The DET B-O
recommended ADJ B-O
dosage NOUN B-O
regimen NOUN B-O
of ADP B-O
laronidase NOUN B-O
is AUX B-O
0.58 NUM B-O
mg NOUN B-O
/ SYM B-O
kg NOUN B-O
body NOUN B-O
weight NOUN B-O
, PUNCT B-O
administered VERB B-O
once ADV B-O
weekly ADV B-O
as ADP B-O
an DET B-O
intravenous ADJ B-LF
( PUNCT B-O
IV PROPN B-AC
) PUNCT B-O
infusion NOUN B-O
. PUNCT B-O

Conducted VERB B-O
by ADP B-O
the DET B-O
Centers PROPN B-LF
for ADP I-LF
Disease PROPN I-LF
Control PROPN I-LF
and CCONJ I-LF
Prevention PROPN I-LF
’s PART B-O
( PUNCT B-O
CDC PROPN B-AC
) PUNCT B-O
National PROPN B-O
Center PROPN B-O
for ADP B-O
Health PROPN B-O
Statistics PROPN B-O
( PUNCT B-O
NCHS PROPN B-O
) PUNCT B-O
, PUNCT B-O
the DET B-O
National PROPN B-LF
Health PROPN I-LF
and CCONJ I-LF
Nutrition PROPN I-LF
Examination PROPN I-LF
Survey PROPN I-LF
( PUNCT B-O
NHANES PROPN B-AC
) PUNCT B-O
collects VERB B-O
nationally ADV B-O
representative ADJ B-O
environmental ADJ B-O
biomonitoring NOUN B-O
data NOUN B-O
from ADP B-O
about ADV B-O
5,000 NUM B-O
annual ADJ B-O
participants NOUN B-O
in ADP B-O
each DET B-O
two NUM B-O
- PUNCT B-O
year NOUN B-O
cycle NOUN B-O
[ PUNCT B-O
2,45–48 NUM B-O
] PUNCT B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
AC PROPN B-AC
, PUNCT B-O
Adherence PROPN B-LF
Club PROPN I-LF
; PUNCT B-O
DiD PROPN B-AC
, PUNCT B-O
difference NOUN B-LF
in ADP I-LF
differences NOUN I-LF
; PUNCT B-O
GEE PROPN B-AC
, PUNCT B-O
generalized ADJ B-LF
estimating NOUN I-LF
equation NOUN I-LF
; PUNCT B-O
GP PROPN B-O
, PUNCT B-O
Gauteng PROPN B-O
Province PROPN B-O
; PUNCT B-O
KZN PROPN B-O
, PUNCT B-O
KwaZulu PROPN B-O
Natal PROPN B-O
; PUNCT B-O
LP PROPN B-O
, PUNCT B-O
Limpopo PROPN B-O
Province PROPN B-O
; PUNCT B-O
NW PROPN B-O
, PUNCT B-O
North PROPN B-O
West PROPN B-O
; PUNCT B-O
RD NOUN B-O
, PUNCT B-O
risk NOUN B-O
difference NOUN B-O
; PUNCT B-O
VL PROPN B-O
, PUNCT B-O
viral ADJ B-O
load NOUN B-O
. PUNCT B-O

We PRON B-O
obtained VERB B-O
FTD PROPN B-AC
GWAS PROPN B-AC
summary NOUN B-O
statistic NOUN B-O
data NOUN B-O
from ADP B-O
phase NOUN B-O
I NUM B-O
of ADP B-O
the DET B-O
International PROPN B-LF
FTD PROPN I-LF
- PUNCT I-LF
Genomics PROPN I-LF
Consortium PROPN I-LF
( PUNCT B-O
IFGC PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
consisted VERB B-O
of ADP B-O
2,154 NUM B-O
clinical ADJ B-O
FTD PROPN B-AC
cases NOUN B-O
and CCONJ B-O
4,308 NUM B-O
controls NOUN B-O
with ADP B-O
genotyped VERB B-O
and CCONJ B-O
imputed VERB B-O
data NOUN B-O
at ADP B-O
6,026,384 NUM B-O
SNPs NOUN B-AC
( PUNCT B-O
Table NOUN B-O
1 NUM B-O
; PUNCT B-O
for ADP B-O
additional ADJ B-O
details NOUN B-O
, PUNCT B-O
see VERB B-O
[ PRON B-O
5 NUM B-O
] PUNCT B-O
) PUNCT B-O
. PUNCT B-O

At ADP B-O
12 NUM B-O
months NOUN B-O
of ADP B-O
age NOUN B-O
, PUNCT B-O
soluble ADJ B-O
and CCONJ B-O
insoluble ADJ B-O
Aβ40 PROPN B-O
and CCONJ B-O
Aβ42 PROPN B-O
were AUX B-O
increased VERB B-O
by ADP B-O
62 NUM B-O
% NOUN B-O
, PUNCT B-O
52 NUM B-O
% NOUN B-O
, PUNCT B-O
62 NUM B-O
% NOUN B-O
, PUNCT B-O
and CCONJ B-O
36 NUM B-O
% NOUN B-O
in ADP B-O
brains NOUN B-O
of ADP B-O
APPPS1 PROPN B-O
– SYM B-O
Adamts13−/− SYM B-O
mice NOUN B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
compared VERB B-O
with ADP B-O
those PRON B-O
in ADP B-O
APPPS1 PROPN B-O
littermates NOUN B-O
( PUNCT B-O
Fig NOUN B-O
4A NUM B-O
and CCONJ B-O
4B NUM B-O
) PUNCT B-O
. PUNCT B-O
Aβ NOUN B-AC
immunostaining NOUN B-O
and CCONJ B-O
thioflavin NOUN B-LF
S PROPN I-LF
( PUNCT B-O
ThS PROPN B-AC
) PUNCT B-O
staining NOUN B-O
confirmed VERB B-O
this DET B-O
observation NOUN B-O
, PUNCT B-O
showing VERB B-O
that SCONJ B-O
the DET B-O
cortical ADJ B-O
and CCONJ B-O
hippocampal ADJ B-O
plaque NOUN B-O
load NOUN B-O
were AUX B-O
markedly ADV B-O
elevated ADJ B-O
in ADP B-O
APPPS1 PROPN B-O
– SYM B-O
Adamts13−/− SYM B-O
mice NOUN B-O
compared VERB B-O
with ADP B-O
APPPS1 PROPN B-O
mice NOUN B-O
( PUNCT B-O
Fig NOUN B-O
4C NUM B-O
, PUNCT B-O
4D NUM B-O
and CCONJ B-O
4E NUM B-O
) PUNCT B-O
. PUNCT B-O
Furthermore ADV B-O
, PUNCT B-O
APPPS1 PROPN B-O
– SYM B-O
Adamts13−/− SYM B-O
mice NOUN B-O
developed VERB B-O
2.3 NUM B-O
- PUNCT B-O
fold ADJ B-O
and CCONJ B-O
1.7 NUM B-O
- PUNCT B-O
fold ADJ B-O
increases NOUN B-O
in ADP B-O
cerebral ADJ B-LF
amyloid NOUN I-LF
angiopathy NOUN I-LF
( PUNCT B-O
CAA PROPN B-AC
) PUNCT B-O
and CCONJ B-O
parenchymal ADJ B-O
amyloid NOUN B-O
deposition NOUN B-O
, PUNCT B-O
respectively ADV B-O
, PUNCT B-O
as SCONJ B-O
measured VERB B-O
by ADP B-O
in ADP B-O
vivo ADJ B-O
multiphoton NOUN B-O
imaging NOUN B-O
of ADP B-O
methoxy NOUN B-O
- PUNCT B-O
X04 NOUN B-O
+ NOUN B-O
amyloid NOUN B-O
plaques NOUN B-O
and CCONJ B-O
Tetramethylrhodamine NOUN B-LF
( PUNCT B-O
TMR)-dextran NOUN B-AC
angiopathy NOUN B-O
( PUNCT B-O
Fig NOUN B-O
4F NUM B-O
and CCONJ B-O
4 NUM B-O
G NOUN B-O
) PUNCT B-O
. PUNCT B-O
Notably ADV B-O
, PUNCT B-O
the DET B-O
CAA PROPN B-AC
load NOUN B-O
was AUX B-O
positively ADV B-O
correlated VERB B-O
with ADP B-O
the DET B-O
BBB PROPN B-AC
permeability NOUN B-O
determined VERB B-O
by ADP B-O
the DET B-O
permeability NOUN B-LF
surface NOUN I-LF
( PUNCT B-O
PS PROPN B-AC
) PUNCT B-O
product NOUN B-O
for ADP B-O
FITC PROPN B-AC
- PUNCT B-O
dextran NOUN B-O
in ADP B-O
APPPS1 PROPN B-O
and CCONJ B-O
APPPS1 PROPN B-O
– SYM B-O
Adamts13−/− SYM B-O
mice NOUN B-O
( PUNCT B-O
Fig NOUN B-O
4H NUM B-O
) PUNCT B-O
. PUNCT B-O

Plus NOUN B-O
– PUNCT B-O
minus NOUN B-O
values NOUN B-O
are AUX B-O
means NOUN B-O
± ADP B-O
standard ADJ B-LF
error NOUN I-LF
( PUNCT B-O
SE NOUN B-AC
) PUNCT B-O
. PUNCT B-O
Analysis NOUN B-O
of ADP B-O
covariance NOUN B-O
was AUX B-O
used VERB B-O
to PART B-O
assess VERB B-O
differences NOUN B-O
between ADP B-O
groups NOUN B-O
at ADP B-O
follow NOUN B-O
- PUNCT B-O
up NOUN B-O
, PUNCT B-O
adjusted VERB B-O
for ADP B-O
baseline NOUN B-O
. PUNCT B-O

The DET B-O
individual ADJ B-O
values NOUN B-O
represent VERB B-O
the DET B-O
percentage NOUN B-O
of ADP B-O
total ADJ B-O
number NOUN B-O
of ADP B-O
dogs NOUN B-O
in ADP B-O
each DET B-O
breed NOUN B-O
with ADP B-O
Merle PROPN B-O
mosaicism NOUN B-O
detected VERB B-O
[ X B-O
ASD PROPN B-AC
– PUNCT B-O
Australian PROPN B-LF
Shepherd PROPN I-LF
Dog PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
40 NUM B-O
) PUNCT B-O
, PUNCT B-O
AK PROPN B-AC
– PUNCT B-O
Australian PROPN B-LF
Koolie PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
23 NUM B-O
) PUNCT B-O
, PUNCT B-O
BC PROPN B-AC
– PUNCT B-O
Border PROPN B-LF
Collie PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
18 NUM B-O
) PUNCT B-O
, PUNCT B-O
D PROPN B-O
– PUNCT B-O
Dachshund PROPN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
9 NUM B-O
) PUNCT B-O
, PUNCT B-O
LC PROPN B-AC
– PUNCT B-O
Louisiana PROPN B-LF
Catahoula PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
73 NUM B-O
) PUNCT B-O
, PUNCT B-O
MAUS PROPN B-AC
– PUNCT B-O
Miniature PROPN B-LF
Australian PROPN I-LF
Shepherd PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
SSD PROPN B-AC
– PUNCT B-O
Shetland PROPN B-LF
Sheepdog PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
FB PROPN B-AC
– PUNCT B-O
French PROPN B-LF
Bulldog PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
2 NUM B-O
) PUNCT B-O
, PUNCT B-O
WS PROPN B-AC
– PUNCT B-O
Welsh PROPN B-LF
Sheepdog PROPN I-LF
( PUNCT B-O
n NOUN B-O
= SYM B-O
3 NUM B-O
) PUNCT B-O
, PUNCT B-O
M PROPN B-O
– PUNCT B-O
Mudi PROPN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
2 NUM B-O
) PUNCT B-O
] PUNCT B-O
of ADP B-O
all DET B-O
tested VERB B-O
dogs NOUN B-O
( PUNCT B-O
n NOUN B-O
= SYM B-O
181 NUM B-O
) PUNCT B-O
. PUNCT B-O

Animals NOUN B-O
were AUX B-O
anaesthetized VERB B-O
by ADP B-O
2%-Isoflurane NOUN B-O
inhalation NOUN B-O
, PUNCT B-O
intubated VERB B-O
and CCONJ B-O
ventilated VERB B-O
with ADP B-O
100 NUM B-O
% NOUN B-O
oxygen NOUN B-O
( PUNCT B-O
0.7 NUM B-O
ml/100 NUM B-O
g NOUN B-O
bodyweight NOUN B-LF
[ PUNCT B-O
BW NOUN B-AC
] PUNCT B-O
, PUNCT B-O
90 NUM B-O
/ SYM B-O
min NOUN B-O
) PUNCT B-O
and CCONJ B-O
cardiac ADJ B-O
hypertrophy NOUN B-O
was AUX B-O
induced VERB B-O
as SCONJ B-O
described VERB B-O
from ADP B-O
Zaha PROPN B-O
and CCONJ B-O
colleagues NOUN B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

Cao PROPN B-O
and CCONJ B-O
Sudhof PROPN B-O
[ X B-O
56 NUM B-O
] X B-O
have AUX B-O
recently ADV B-O
discovered VERB B-O
that PRON B-O
the DET B-O
APP PROPN B-AC
C PROPN B-O
- NOUN B-O
terminal ADJ B-O
fragment NOUN B-O
generated VERB B-O
by ADP B-O
α- NOUN B-O
or CCONJ B-O
β NOUN B-O
- NOUN B-O
secretase NOUN B-O
is AUX B-O
itself PRON B-O
cleaved VERB B-O
to PART B-O
release VERB B-O
Aβ PROPN B-AC
and CCONJ B-O
an DET B-O
APP PROPN B-LF
intracellular ADJ I-LF
domain NOUN I-LF
( PUNCT B-O
AICD PROPN B-AC
) PUNCT B-O
that PRON B-O
diffuses VERB B-O
into ADP B-O
the DET B-O
nucleus NOUN B-O
, PUNCT B-O
possibly ADV B-O
acting VERB B-O
there ADV B-O
as ADP B-O
a DET B-O
transcription NOUN B-O
factor NOUN B-O
. PUNCT B-O

ALD PROPN B-AC
, PUNCT B-O
alcoholic ADJ B-LF
liver NOUN I-LF
disease NOUN I-LF
; PUNCT B-O
HCV PROPN B-AC
, PUNCT B-O
hepatitis NOUN B-LF
C PROPN I-LF
virus NOUN I-LF
; PUNCT B-O
NAFLD PROPN B-AC
, PUNCT B-O
non ADJ B-O
- ADJ B-O
alcoholic ADJ B-O
fatty ADJ B-O
liver NOUN B-O
disease NOUN B-O
. PUNCT B-O

LDSm NOUN B-AC
= PUNCT B-O
Latent PROPN B-LF
Difference PROPN I-LF
Score PROPN I-LF
model NOUN I-LF
, PUNCT B-O
Latent PROPN B-O
GSE PROPN B-AC
= PUNCT B-O
General PROPN B-LF
Self PROPN I-LF
- PUNCT I-LF
Efficacy PROPN I-LF
, PUNCT B-O
TCS PROPN B-AC
= PUNCT B-O
Transition PROPN B-LF
Competence PROPN I-LF
Scale PROPN I-LF
, PUNCT B-O
PAM PROPN B-AC
= PUNCT B-O
Patient PROPN B-O
Activation PROPN B-O
Measurement PROPN B-O
– PUNCT B-O
German PROPN B-O
Youth PROPN B-O
Version PROPN B-O
. PUNCT B-O

Medium ADJ B-LF
- PUNCT I-LF
chain NOUN I-LF
acyl NOUN I-LF
- PUNCT I-LF
CoA NOUN I-LF
dehydrogenase NOUN I-LF
( PUNCT B-O
MCAD PROPN B-AC
) PUNCT B-O
deficiency NOUN B-O
is AUX B-O
one NUM B-O
of ADP B-O
the DET B-O
most ADV B-O
common ADJ B-O
inherited VERB B-O
disorders NOUN B-O
of ADP B-O
metabolism NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
DAS28 PROPN B-AC
, PUNCT B-O
Disease PROPN B-LF
Activity PROPN I-LF
Score-28 PROPN I-LF
; PUNCT B-O
TNFi PROPN B-AC
, PUNCT B-O
tumour NOUN B-O
necrosis NOUN B-O
factor NOUN B-O
inhibitor NOUN B-O

Within ADP B-O
a DET B-O
Developmental PROPN B-LF
Origins PROPN I-LF
of ADP I-LF
Health PROPN I-LF
and CCONJ I-LF
Disease PROPN I-LF
( PUNCT B-O
DOHaD PROPN B-AC
) PUNCT B-O
framework NOUN B-O
, PUNCT B-O
the DET B-O
first ADJ B-O
1,000 NUM B-O
days NOUN B-O
of ADP B-O
life NOUN B-O
, PUNCT B-O
i.e. X B-O
, PUNCT B-O
the DET B-O
period NOUN B-O
from ADP B-O
conception NOUN B-O
to ADP B-O
age NOUN B-O
2 NUM B-O
years NOUN B-O
, PUNCT B-O
is AUX B-O
regarded VERB B-O
as ADP B-O
a DET B-O
critical ADJ B-O
period NOUN B-O
for ADP B-O
long ADJ B-O
- PUNCT B-O
term NOUN B-O
cardiovascular ADJ B-O
health NOUN B-O
[ PUNCT B-O
1 NUM B-O
] PUNCT B-O
. PUNCT B-O

As ADP B-O
a DET B-O
first ADJ B-O
step NOUN B-O
toward ADP B-O
this DET B-O
goal NOUN B-O
, PUNCT B-O
we PRON B-O
asked VERB B-O
whether SCONJ B-O
conditions NOUN B-O
could AUX B-O
be AUX B-O
found VERB B-O
that PRON B-O
allow VERB B-O
cultured VERB B-O
cells NOUN B-O
to ADP B-O
proliferate VERB B-O
despite SCONJ B-O
an DET B-O
activated VERB B-O
UPR NOUN B-AC
. PUNCT B-O
We PRON B-O
chose VERB B-O
as ADP B-O
our PRON B-O
experimental ADJ B-O
cell NOUN B-O
type NOUN B-O
mouse NOUN B-LF
embryonic ADJ I-LF
fibroblasts NOUN I-LF
( PUNCT B-O
MEFs PROPN B-AC
) PUNCT B-O
, PUNCT B-O
because SCONJ B-O
, PUNCT B-O
as ADP B-O
primary ADJ B-O
non ADJ B-O
- ADJ B-O
immortalized ADJ B-O
cells NOUN B-O
, PUNCT B-O
they PRON B-O
are AUX B-O
less ADV B-O
likely ADJ B-O
than ADP B-O
immortalized ADJ B-O
cell NOUN B-O
lines NOUN B-O
to ADP B-O
be AUX B-O
intrinsically ADV B-O
resistant ADJ B-O
to ADP B-O
stress NOUN B-O
. PUNCT B-O

CDS PROPN B-AC
, PUNCT B-O
coding VERB B-LF
DNA NOUN I-LF
sequence NOUN I-LF
; PUNCT B-O
RPF PROPN B-AC
, PUNCT B-O
ribosome NOUN B-LF
- PUNCT I-LF
protected VERB I-LF
mRNA NOUN I-LF
fragment NOUN I-LF
; PUNCT B-O
SE PROPN B-AC
, PUNCT B-O
standard ADJ B-LF
error NOUN I-LF
; PUNCT B-O
TE NOUN B-AC
, PUNCT B-O
translational ADJ B-LF
efficiency NOUN I-LF
; PUNCT B-O
uORF NOUN B-AC
, PUNCT B-O
upstream ADJ B-LF
open ADJ I-LF
reading NOUN I-LF
frame NOUN I-LF
. PUNCT B-O

We PRON B-O
did AUX B-O
not PART B-O
find VERB B-O
support NOUN B-O
for ADP B-O
this DET B-O
hypothesis NOUN B-O
in ADP B-O
our PRON B-O
data NOUN B-O
, PUNCT B-O
as ADP B-O
there PRON B-O
was VERB B-O
no DET B-O
association NOUN B-O
between ADP B-O
antagonism NOUN B-O
and CCONJ B-O
higher ADJ B-O
levels NOUN B-O
of ADP B-O
pleiotropy NOUN B-O
, PUNCT B-O
measured VERB B-O
either CCONJ B-O
as ADP B-O
tissue NOUN B-O
breadth NOUN B-O
τ NOUN B-O
[ X B-O
43 NUM B-O
] X B-O
( PUNCT B-O
W NOUN B-O
= SYM B-O
1,264,700 NUM B-O
, PUNCT B-O
P NOUN B-O
= SYM B-O
0.70 NUM B-O
) PUNCT B-O
or CCONJ B-O
as ADP B-O
the DET B-O
number NOUN B-O
of ADP B-O
protein NOUN B-LF
– PUNCT I-LF
protein NOUN I-LF
interactions NOUN I-LF
( PUNCT B-O
PPIs PROPN B-AC
) PUNCT B-O
[ X B-O
44 NUM B-O
] X B-O
( PUNCT B-O
F1,5276 NUM B-O
= SYM B-O
2.43 NUM B-O
, PUNCT B-O
P NOUN B-O
= SYM B-O
0.12 NUM B-O
) PUNCT B-O
. PUNCT B-O

IUGR PROPN B-AC
, PUNCT B-O
intrauterine ADJ B-LF
growth NOUN I-LF
restricted VERB I-LF
; PUNCT B-O
UNI PROPN B-AC
- PUNCT B-AC
X PROPN B-AC
, PUNCT B-O
uninephrectomized VERB B-LF
. PUNCT B-O

ACC PROPN B-AC
, PUNCT B-O
acetyl NOUN B-LF
- PUNCT I-LF
coA NOUN I-LF
carboxylase NOUN I-LF
; PUNCT B-O
ChREBP PROPN B-AC
, PUNCT B-O
carbohydrate NOUN B-LF
- PUNCT I-LF
responsive ADJ I-LF
element NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
; PUNCT B-O
CON PROPN B-O
, PUNCT B-O
control NOUN B-O
; PUNCT B-O
E2 PROPN B-AC
, PUNCT B-O
estradiol NOUN B-LF
; PUNCT B-O
EHHADH PROPN B-AC
, PUNCT B-O
enoyl NOUN B-O
- PUNCT B-O
coA NOUN B-O
hydratase NOUN B-O
and CCONJ B-O
3 NUM B-O
- PUNCT B-O
hydroxyacyl NOUN B-O
coA NOUN B-O
; PUNCT B-O
Fas PROPN B-AC
, PUNCT B-O
fatty ADJ B-LF
acid NOUN I-LF
synthase NOUN I-LF
; PUNCT B-O
GAPDH PROPN B-AC
, PUNCT B-O
glyceraldehyde-3 NOUN B-LF
- PUNCT I-LF
phosphate NOUN I-LF
dehydrogenase NOUN I-LF
; PUNCT B-O
HFD PROPN B-AC
, PUNCT B-O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
; PUNCT B-O
IPITT PROPN B-AC
, PUNCT B-O
intraperitoneal ADJ B-LF
insulin NOUN I-LF
tolerance NOUN I-LF
test NOUN I-LF
; PUNCT B-O
ME1 PROPN B-AC
, PUNCT B-O
cytosolic ADJ B-LF
malic ADJ I-LF
enzyme NOUN I-LF
1 NUM I-LF
; PUNCT B-O
OVX PROPN B-AC
, PUNCT B-O
ovariectomy NOUN B-LF
; PUNCT B-O
p NOUN B-AC
- PUNCT B-AC
ACC PROPN B-AC
, PUNCT B-O
phosphorylated VERB B-LF
acetyl NOUN I-LF
- PUNCT I-LF
coA NOUN I-LF
carboxylase NOUN I-LF
; PUNCT B-O
SCD-1 PROPN B-AC
, PUNCT B-O
stearoyl NOUN B-LF
- PUNCT I-LF
coA NOUN I-LF
desaturase-1 NOUN I-LF
; PUNCT B-O
SREBP-1c PROPN B-AC
, PUNCT B-O
sterol NOUN B-LF
regulatory ADJ I-LF
element NOUN I-LF
- PUNCT I-LF
binding VERB I-LF
protein NOUN I-LF
1 NUM I-LF
- PUNCT I-LF
c NOUN I-LF
; PUNCT B-O
TG PROPN B-AC
, PUNCT B-O
triglyceride NOUN B-LF
; PUNCT B-O
WT PROPN B-AC
, PUNCT B-O
wild ADJ B-O
- PUNCT B-O
type NOUN B-O
. PUNCT B-O

This DET B-O
study NOUN B-O
used VERB B-O
the DET B-O
monthly ADJ B-O
income NOUN B-O
calculated VERB B-O
from ADP B-O
the DET B-O
NHI PROPN B-O
premium NOUN B-O
as ADP B-O
a DET B-O
proxy NOUN B-O
for ADP B-O
individual ADJ B-O
socioeconomic ADJ B-LF
status NOUN I-LF
( PUNCT B-O
SES PROPN B-AC
) PUNCT B-O
. PUNCT B-O
Individuals NOUN B-O
were AUX B-O
classified VERB B-O
into ADP B-O
three NUM B-O
income NOUN B-O
groups NOUN B-O
: PUNCT B-O
( PUNCT B-O
1 X B-O
) PUNCT B-O
low ADJ B-O
( PUNCT B-O
< PUNCT B-O
NT$15,840 NUM B-O
per ADP B-O
month NOUN B-O
) PUNCT B-O
; PUNCT B-O
( PUNCT B-O
2 X B-O
) PUNCT B-O
medium ADJ B-O
( PUNCT B-O
NT$15,840 NUM B-O
– SYM B-O
NT$25,000 NUM B-O
per ADP B-O
month NOUN B-O
) PUNCT B-O
; PUNCT B-O
and CCONJ B-O
( PUNCT B-O
3 X B-O
) PUNCT B-O
high ADJ B-O
( PUNCT B-O
> PUNCT B-O
NT$25,000 NUM B-O
per ADP B-O
month NOUN B-O
) PUNCT B-O
. PUNCT B-O

Initial ADJ B-O
thematic ADJ B-O
analysis NOUN B-O
[ X B-O
37 NUM B-O
] X B-O
and CCONJ B-O
subsequent ADJ B-O
analysis NOUN B-O
sensitised VERB B-O
by ADP B-O
the DET B-O
Theoretical PROPN B-LF
Framework PROPN I-LF
of ADP I-LF
Acceptability PROPN I-LF
( PUNCT B-O
TFA PROPN B-AC
) PUNCT B-O
[ X B-O
38 NUM B-O
] X B-O
were AUX B-O
undertaken VERB B-O
. PUNCT B-O

Two NUM B-O
homologous ADJ B-O
GTPases NOUN B-O
, PUNCT B-O
one NUM B-O
in ADP B-O
the DET B-O
signal NOUN B-LF
recognition NOUN I-LF
particle NOUN I-LF
( PUNCT B-O
SRP PROPN B-AC
) PUNCT B-O
and CCONJ B-O
one NUM B-O
in ADP B-O
the DET B-O
SRP PROPN B-LF
receptor NOUN I-LF
( PUNCT B-O
SR PROPN B-AC
; PUNCT B-O
called VERB B-O
Ffh PROPN B-O
and CCONJ B-O
FtsY PROPN B-O
in ADP B-O
bacteria NOUN B-O
, PUNCT B-O
respectively ADV B-O
) PUNCT B-O
, PUNCT B-O
mediate VERB B-O
the DET B-O
cotranslational ADJ B-O
targeting NOUN B-O
of ADP B-O
membrane NOUN B-O
and CCONJ B-O
secretory NOUN B-O
proteins NOUN B-O
to ADP B-O
the DET B-O
eukaryotic ADJ B-O
endoplasmic ADJ B-LF
reticulum NOUN I-LF
( PUNCT B-O
ER PROPN B-AC
) PUNCT B-O
membrane NOUN B-O
or CCONJ B-O
the DET B-O
bacterial ADJ B-O
plasma NOUN B-O
membrane NOUN B-O
. PUNCT B-O

- PUNCT B-O
No DET B-O
need NOUN B-O
for ADP B-O
" PUNCT B-O
Basic PROPN B-LF
Metabolic PROPN I-LF
Panel PROPN I-LF
[ PUNCT B-O
BMP PROPN B-AC
] PUNCT B-O
: PUNCT B-O
" PUNCT B-O
, PUNCT B-O
" PUNCT B-O
Liver PROPN B-LF
Function PROPN I-LF
Test PROPN I-LF
[ PUNCT B-O
LFT PROPN B-AC
] PUNCT B-O
: PUNCT B-O
" PUNCT B-O
as SCONJ B-O
the DET B-O
details NOUN B-O
are AUX B-O
followed VERB B-O
. PUNCT B-O

Uric NOUN B-O
acid NOUN B-O
has AUX B-O
been AUX B-O
shown VERB B-O
to ADP B-O
associate VERB B-O
with ADP B-O
vascular ADJ B-O
calcification NOUN B-O
and CCONJ B-O
with ADP B-O
carotid ADJ B-LF
intima NOUN I-LF
- PUNCT I-LF
media NOUN I-LF
thickness NOUN I-LF
( PUNCT B-O
CIMT PROPN B-AC
) PUNCT B-O
and CCONJ B-O
to ADP B-O
suppress VERB B-O
the DET B-O
1 NUM B-O
α NOUN B-O
- PUNCT B-O
hydroxylase NOUN B-O
enzyme NOUN B-O
leading VERB B-O
to ADP B-O
lower ADJ B-O
1,25 NUM B-LF
- PUNCT I-LF
dihydroxyvitamin NOUN I-LF
D PROPN I-LF
( PUNCT B-O
1,25(OH)2D NUM B-AC
) PUNCT B-O
and CCONJ B-O
higher ADJ B-O
intact ADJ B-LF
parathyroid ADJ I-LF
hormone NOUN I-LF
( PUNCT B-O
iPTH PROPN B-AC
) PUNCT B-O
levels NOUN B-O
. PUNCT B-O

Analysis NOUN B-O
of ADP B-O
pairwise ADJ B-O
distances NOUN B-O
showed VERB B-O
that SCONJ B-O
matK+rbcL+trnL NOUN B-LF
- PUNCT I-LF
F+trnH NOUN I-LF
- PUNCT I-LF
psbA+ITS NOUN I-LF
( PUNCT B-O
MRTPI NOUN B-AC
) PUNCT B-O
had VERB B-O
the DET B-O
greatest ADJ B-O
value NOUN B-O
and CCONJ B-O
rbcL NOUN B-O
the DET B-O
least ADJ B-O
. PUNCT B-O

Body NOUN B-LF
mass NOUN I-LF
index NOUN I-LF
( PUNCT B-O
BMI NOUN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
as ADP B-O
body NOUN B-O
weight NOUN B-O
( PUNCT B-O
kg)/height NOUN B-O
( PUNCT B-O
m2 NOUN B-O
) PUNCT B-O
. PUNCT B-O

Cytokines NOUN B-O
and CCONJ B-O
interferons NOUN B-O
( PUNCT B-O
all PRON B-O
called VERB B-O
cytokines NOUN B-O
from ADP B-O
here ADV B-O
on ADV B-O
) PUNCT B-O
were AUX B-O
determined VERB B-O
in ADP B-O
cell NOUN B-O
culture NOUN B-O
supernatants NOUN B-O
from ADP B-O
equine ADJ B-O
peripheral ADJ B-LF
blood NOUN I-LF
mononuclear ADJ I-LF
cells NOUN I-LF
( PUNCT B-O
PBMC PROPN B-AC
) PUNCT B-O
using VERB B-O
an DET B-O
fluorescent ADJ B-O
beads NOUN B-O
- NOUN B-O
based VERB B-O
equine ADJ B-O
cytokine NOUN B-O
multiplex NOUN B-O
assays NOUN B-O
for ADP B-O
IFN NOUN B-O
- NOUN B-O
α NOUN B-O
, PUNCT B-O
IL-4 NOUN B-AC
, PUNCT B-O
IL-10 NOUN B-O
, PUNCT B-O
IL-17 NOUN B-O
and CCONJ B-O
IFN NOUN B-AC
- NOUN B-AC
γ NOUN B-AC
as SCONJ B-O
previously ADV B-O
described VERB B-O
[ PUNCT B-O
38 NUM B-O
] PUNCT B-O
. PUNCT B-O

Study NOUN B-O
villages NOUN B-O
are AUX B-O
shown VERB B-O
with ADP B-O
dark ADJ B-O
brown ADJ B-O
dots NOUN B-O
; PUNCT B-O
villages NOUN B-O
with ADP B-O
light ADJ B-LF
trap NOUN I-LF
captures NOUN I-LF
( PUNCT B-O
LTC PROPN B-AC
) PUNCT B-O
are AUX B-O
marked VERB B-O
with ADP B-O
light ADJ B-O
brown ADJ B-O
dots NOUN B-O
. PUNCT B-O

The DET B-O
HCP PROPN B-AC
dataset NOUN B-O
allowed VERB B-O
us PRON B-O
to ADP B-O
investigate VERB B-O
how SCONJ B-O
the DET B-O
magnitude NOUN B-O
of ADP B-O
the DET B-O
brain NOUN B-O
’s PART B-O
global ADJ B-LF
signal NOUN I-LF
( PUNCT B-O
GS PROPN B-AC
) PUNCT B-O
fluctuation NOUN B-O
( PUNCT B-O
also ADV B-O
referred VERB B-O
to ADP B-O
as ADP B-O
amplitude NOUN B-O
in ADP B-O
the DET B-O
literature NOUN B-O
) PUNCT B-O
varies VERB B-O
throughout ADP B-O
the DET B-O
day NOUN B-O
. PUNCT B-O

In ADP B-O
the DET B-O
NHIRD PROPN B-AC
, PUNCT B-O
disease NOUN B-O
identification NOUN B-O
is AUX B-O
based VERB B-O
on ADP B-O
the DET B-O
International PROPN B-LF
Classification PROPN I-LF
of ADP I-LF
Diseases PROPN I-LF
, PUNCT I-LF
9th ADJ I-LF
Revision PROPN I-LF
, PUNCT I-LF
Clinical PROPN I-LF
Modification PROPN I-LF
( PUNCT B-O
ICD-9 PROPN B-AC
- PUNCT B-AC
CM PROPN B-AC
) PUNCT B-O
, PUNCT B-O
which PRON B-O
was AUX B-O
coded VERB B-O
by ADP B-O
a DET B-O
qualified ADJ B-O
clinician NOUN B-O
according VERB B-O
to ADP B-O
the DET B-O
clinical ADJ B-O
assessment NOUN B-O
, PUNCT B-O
including VERB B-O
disease NOUN B-O
presentation NOUN B-O
, PUNCT B-O
physical ADJ B-O
findings NOUN B-O
and CCONJ B-O
laboratory NOUN B-O
tests NOUN B-O
. PUNCT B-O

We PRON B-O
also ADV B-O
examined VERB B-O
the DET B-O
role NOUN B-O
of ADP B-O
TNF PROPN B-LF
Receptor PROPN I-LF
Associated PROPN I-LF
Factors PROPN I-LF
( PUNCT B-O
TRAF PROPN B-AC
) PUNCT B-O
in ADP B-O
the DET B-O
regulation NOUN B-O
of ADP B-O
CX3CL1 PROPN B-O
and CCONJ B-O
TNF PROPN B-O
- PUNCT B-O
α NOUN B-O
expression NOUN B-O
. PUNCT B-O

Se NOUN B-AC
status NOUN B-O
was AUX B-O
determined VERB B-O
by ADP B-O
measuring VERB B-O
both CCONJ B-O
selenoprotein NOUN B-LF
P NOUN I-LF
( PUNCT B-O
SePP PROPN B-AC
) PUNCT B-O
and CCONJ B-O
plasma NOUN B-O
Se NOUN B-AC
concentrations NOUN B-O
. PUNCT B-O

The DET B-O
underlying VERB B-O
numerical ADJ B-O
data NOUN B-O
can AUX B-O
be AUX B-O
found VERB B-O
in ADP B-O
S1 PROPN B-O
and CCONJ B-O
S2 PROPN B-O
Data NOUN B-O
. PUNCT B-O
3 NUM B-AC
' NOUN B-AC
UTR NOUN B-AC
, PUNCT B-O
3 NUM B-O
' NOUN B-O
untranslated VERB B-LF
region NOUN I-LF
; PUNCT B-O
dpf NOUN B-AC
, PUNCT B-O
days NOUN B-LF
post ADP I-LF
fertilization NOUN I-LF
; PUNCT B-O
F NOUN B-AC
- NOUN B-AC
actin NOUN B-AC
, PUNCT B-O
filamentous ADJ B-LF
actin NOUN I-LF
; PUNCT B-O
smFISH PROPN B-AC
, PUNCT B-O
single ADJ B-LF
molecule NOUN I-LF
fluorescent ADJ I-LF
in ADP I-LF
situ NOUN I-LF
hybridization NOUN I-LF
. PUNCT B-O

ASCVD NOUN B-AC
, PUNCT B-O
atherosclerotic ADJ B-LF
cardiovascular ADJ I-LF
disease NOUN I-LF
; PUNCT B-O
AUC PROPN B-AC
, PUNCT B-O
areas NOUN B-LF
under ADP I-LF
the DET I-LF
curve NOUN I-LF
; PUNCT B-O
CACS PROPN B-AC
, PUNCT B-O
coronary ADJ B-LF
artery NOUN I-LF
calcium NOUN I-LF
scores NOUN I-LF
; PUNCT B-O
CAP PROPN B-AC
, PUNCT B-O
calcified VERB B-LF
plaque NOUN I-LF
; PUNCT B-O
NCAP PROPN B-AC
, PUNCT B-O
noncalcified ADJ B-LF
plaque NOUN I-LF
; PUNCT B-O
MCAP PROPN B-AC
, PUNCT B-O
mixed VERB B-LF
plaque NOUN I-LF
. PUNCT B-O

We PRON B-O
initially ADV B-O
observed VERB B-O
that SCONJ B-O
GCs NOUN B-AC
migrate VERB B-O
in ADP B-O
chain NOUN B-O
- PUNCT B-O
like ADJ B-O
structures NOUN B-O
toward ADP B-O
the DET B-O
midbrain NOUN B-LF
- PUNCT I-LF
hindbrain NOUN I-LF
boundary NOUN I-LF
( PUNCT B-O
MHB PROPN B-AC
) PUNCT B-O
. PUNCT B-O
To PART B-O
investigate VERB B-O
these DET B-O
cellular ADJ B-O
interactions NOUN B-O
in ADP B-O
more ADJ B-O
detail NOUN B-O
, PUNCT B-O
we PRON B-O
first ADV B-O
addressed VERB B-O
whether SCONJ B-O
glial ADJ B-O
cells NOUN B-O
are AUX B-O
present ADJ B-O
in ADP B-O
the DET B-O
zebrafish NOUN B-O
cerebellum NOUN B-O
and CCONJ B-O
hindbrain NOUN B-O
before ADP B-O
and CCONJ B-O
during ADP B-O
onset NOUN B-O
of ADP B-O
GC NOUN B-AC
migration NOUN B-O
( PUNCT B-O
36 NUM B-O
hpf NOUN B-AC
, PUNCT B-O
48 NUM B-O
hpf NOUN B-AC
) PUNCT B-O
. PUNCT B-O

Other ADJ B-O
interactions NOUN B-O
occur VERB B-O
with ADP B-O
EGF PROPN B-AC
( PUNCT B-O
epidermal ADJ B-LF
growth NOUN I-LF
factor NOUN I-LF
) PUNCT B-O
and CCONJ B-O
its PRON B-O
respective ADJ B-O
receptor NOUN B-O
( PUNCT B-O
EGFR PROPN B-AC
) PUNCT B-O
, PUNCT B-O
CFTR PROPN B-AC
( PUNCT B-O
ATP NOUN B-O
- PUNCT B-O
binding VERB B-O
cassette NOUN B-O
sub NOUN B-O
- PUNCT B-O
family NOUN B-O
C PROPN B-O
, PUNCT B-O
member NOUN B-O
7 NUM B-O
) PUNCT B-O
, PUNCT B-O
M6PR PROPN B-AC
( PUNCT B-O
mannose-6 NOUN B-O
- PUNCT B-O
phosphate NOUN B-O
receptor NOUN B-O
, PUNCT B-O
cation NOUN B-O
dependent ADJ B-O
) PUNCT B-O
, PUNCT B-O
RAB5A PROPN B-AC
( PUNCT B-O
member NOUN B-LF
RAS PROPN I-LF
oncogene NOUN I-LF
family NOUN I-LF
) PUNCT B-O
and CCONJ B-O
APOB PROPN B-AC
( PUNCT B-O
apolipoprotein NOUN B-LF
B NOUN I-LF
) PUNCT B-O
. PUNCT B-O

PKA PROPN B-AC
holoenzymes NOUN B-O
, PUNCT B-O
especially ADV B-O
RII PROPN B-O
holoenzymes NOUN B-O
, PUNCT B-O
typically ADV B-O
bind VERB B-O
with ADP B-O
high ADJ B-O
affinity NOUN B-O
to ADP B-O
an DET B-O
amphipathic ADJ B-O
helix NOUN B-O
that PRON B-O
is AUX B-O
embedded VERB B-O
in ADP B-O
scaffold NOUN B-O
proteins NOUN B-O
referred VERB B-O
to ADP B-O
as ADP B-O
A PROPN B-LF
- PUNCT I-LF
Kinase PROPN I-LF
- PUNCT I-LF
Anchoring PROPN I-LF
Proteins PROPN I-LF
( PUNCT B-O
AKAPs PROPN B-AC
) PUNCT B-O
through ADP B-O
their PRON B-O
D NOUN B-AC
/ SYM B-AC
D NOUN B-AC
domains NOUN B-O
[ X B-O
35–37 NUM B-O
] PUNCT B-O
. PUNCT B-O

Cytology NOUN B-O
results NOUN B-O
were AUX B-O
reported VERB B-O
according VERB B-O
to ADP B-O
the DET B-O
Bethesda PROPN B-O
System PROPN B-O
2001 NUM B-O
and CCONJ B-O
CC PROPN B-AC
cases NOUN B-O
were AUX B-O
staged VERB B-O
according VERB B-O
to ADP B-O
the DET B-O
International PROPN B-LF
Federation PROPN I-LF
of ADP I-LF
Gynecology PROPN I-LF
and CCONJ I-LF
Obstetrics PROPN I-LF
( PUNCT B-O
FIGO PROPN B-AC
) PUNCT B-O
. PUNCT B-O

To PART B-O
address VERB B-O
this DET B-O
issue NOUN B-O
, PUNCT B-O
we PRON B-O
utilized VERB B-O
clockGAL4 PROPN B-O
[ PUNCT B-O
25 NUM B-O
] PUNCT B-O
, PUNCT B-O
which PRON B-O
drives VERB B-O
broad ADJ B-O
expression NOUN B-O
among ADP B-O
all DET B-O
major ADJ B-O
circadian ADJ B-O
neuronal ADJ B-O
groups NOUN B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
but CCONJ B-O
relatively ADV B-O
limited ADJ B-O
noncircadian ADJ B-O
expression NOUN B-O
, PUNCT B-O
including VERB B-O
the DET B-O
pars NOUN B-LF
intercerebralis NOUN I-LF
( PUNCT B-O
PI PROPN B-AC
) PUNCT B-O
and CCONJ B-O
cells NOUN B-O
surrounding VERB B-O
circadian ADJ B-O
neurons NOUN B-O
[ PUNCT B-O
16 NUM B-O
] PUNCT B-O
. PUNCT B-O

In ADP B-O
order NOUN B-O
to PART B-O
directly ADV B-O
visualize VERB B-O
the DET B-O
destabilization NOUN B-O
dependent ADJ B-O
on ADP B-O
nucleotide NOUN B-O
state NOUN B-O
, PUNCT B-O
we PRON B-O
developed VERB B-O
a DET B-O
single ADJ B-O
molecule NOUN B-O
assay NOUN B-O
using VERB B-O
FtsZ PROPN B-O
- PUNCT B-O
YFP PROPN B-AC
- PUNCT B-O
mts NOUN B-AC
incubated VERB B-O
with ADP B-O
fluorescently ADV B-O
labeled VERB B-O
nanobodies NOUN B-O
( PUNCT B-O
green ADJ B-LF
fluorescent ADJ I-LF
protein NOUN I-LF
[ SYM B-O
GFP]-Booster PROPN B-AC
- PUNCT B-O
Atto647N PROPN B-O
, PUNCT B-O
see VERB B-O
Materials NOUN B-O
and CCONJ B-O
methods NOUN B-O
) PUNCT B-O
( PUNCT B-O
Fig NOUN B-O
5A NOUN B-O
) PUNCT B-O
to PART B-O
investigate VERB B-O
the DET B-O
protein NOUN B-O
turnover NOUN B-O
at ADP B-O
the DET B-O
membrane NOUN B-O
, PUNCT B-O
implying VERB B-O
that SCONJ B-O
faster ADJ B-O
disassembly NOUN B-O
suggests VERB B-O
higher ADJ B-O
destabilization NOUN B-O
. PUNCT B-O

Our PRON B-O
large ADJ B-O
sample NOUN B-O
size NOUN B-O
allowed VERB B-O
us PRON B-O
to ADP B-O
calculate VERB B-O
hazard NOUN B-LF
ratios NOUN I-LF
( PUNCT B-O
HRs NOUN B-AC
) PUNCT B-O
of ADP B-O
mortality NOUN B-O
and CCONJ B-O
years NOUN B-O
of ADP B-O
life NOUN B-O
gained VERB B-O
after ADP B-O
age NOUN B-O
40 NUM B-O
according VERB B-O
to ADP B-O
fine ADJ B-O
gradations NOUN B-O
of ADP B-O
activity NOUN B-O
levels NOUN B-O
and CCONJ B-O
in ADP B-O
subgroups NOUN B-O
for ADP B-O
which PRON B-O
, PUNCT B-O
to ADP B-O
our PRON B-O
knowledge NOUN B-O
, PUNCT B-O
no DET B-O
prior ADJ B-O
estimates NOUN B-O
are AUX B-O
available ADJ B-O
, PUNCT B-O
such ADJ B-O
as ADP B-O
black ADJ B-O
individuals NOUN B-O
, PUNCT B-O
smokers NOUN B-O
, PUNCT B-O
and CCONJ B-O
persons NOUN B-O
with ADP B-O
a DET B-O
history NOUN B-O
of ADP B-O
cancer NOUN B-O
and/or CCONJ B-O
heart NOUN B-O
disease NOUN B-O
. PUNCT B-O

Abbreviations NOUN B-O
: PUNCT B-O
8 NUM B-AC
- NOUN B-AC
OHdG NOUN B-AC
: PUNCT B-O
8 NUM B-O
- NOUN B-O
hydroxy-2′-deoxyguanosine NOUN B-O
; PUNCT B-O
8 NUM B-O
- NOUN B-O
iso NOUN B-AC
- NOUN B-AC
PGF2a NOUN B-AC
: PUNCT B-O
8 NUM B-O
- NOUN B-O
iso NOUN B-O
- NOUN B-O
prostaglandin NOUN B-O
F2a NOUN B-O
; PUNCT B-O
MDA NOUN B-AC
: PUNCT B-O
malondialdehyde NOUN B-LF
; PUNCT B-O
6 NUM B-AC
- NOUN B-AC
CN NOUN B-AC
: PUNCT B-O
6 NUM B-LF
- NOUN I-LF
chloronicotinic ADJ I-LF
acid NOUN I-LF
; PUNCT B-O
CI NOUN B-O
: PUNCT B-O
confidence NOUN B-O
interval NOUN B-O

We PRON B-O
investigated VERB B-O
the DET B-O
participation NOUN B-O
of ADP B-O
mitogen NOUN B-O
- PUNCT B-O
activated VERB B-O
protein NOUN B-O
kinase NOUN B-O
kinase NOUN B-O
( PUNCT B-O
MEK PROPN B-AC
) PUNCT B-O
kinase NOUN B-O
1 NUM B-O
( PUNCT B-O
MEKK1)/MEK1 PROPN B-AC
/ SYM B-O
ERK1 PROPN B-O
/ SYM B-O
GLI-1/2 PROPN B-O
and CCONJ B-O
activator NOUN B-LF
protein-1 NOUN I-LF
( PUNCT B-O
AP-1 PROPN B-AC
) PUNCT B-O
signaling NOUN B-O
in ADP B-O
hypoxia NOUN B-O
- PUNCT B-O
induced VERB B-O
CTGF PROPN B-AC
expression NOUN B-O
in ADP B-O
human ADJ B-O
lung NOUN B-O
fibroblasts NOUN B-O
. PUNCT B-O

HFD PROPN B-AC
stands VERB B-O
for ADP B-O
high ADJ B-LF
- PUNCT I-LF
fat NOUN I-LF
diet NOUN I-LF
. PUNCT B-O

Therefore ADV B-O
, PUNCT B-O
we PRON B-O
performed VERB B-O
a DET B-O
FTIR PROPN B-AC
investigation NOUN B-O
on ADP B-O
paraffin NOUN B-O
sections NOUN B-O
of ADP B-O
human ADJ B-O
hands NOUN B-O
by ADP B-O
principle ADJ B-LF
component NOUN I-LF
analysis NOUN I-LF
( PUNCT B-O
PCA NOUN B-AC
) PUNCT B-O
in ADP B-O
order NOUN B-O
to PART B-O
determine VERB B-O
variance NOUN B-O
of ADP B-O
protein NOUN B-O
structures NOUN B-O
between ADP B-O
electrical ADJ B-O
mark NOUN B-O
and CCONJ B-O
normal ADJ B-O
skin NOUN B-O
. PUNCT B-O

D NOUN B-AC
/ SYM B-AC
R NOUN B-AC
, PUNCT B-O
dangerous ADJ B-LF
and CCONJ I-LF
rich ADJ I-LF
; PUNCT B-O
ITI NOUN B-O
, PUNCT B-O
intertrial ADJ B-O
interval NOUN B-O
; PUNCT B-O
S NOUN B-AC
/ SYM B-AC
P NOUN B-AC
, PUNCT B-O
safe ADJ B-LF
and CCONJ I-LF
poor ADJ I-LF
; PUNCT B-O
S NOUN B-AC
/ SYM B-AC
R NOUN B-AC
, PUNCT B-O
safe ADJ B-LF
and CCONJ I-LF
rich ADJ I-LF
. PUNCT B-O

We PRON B-O
used VERB B-O
the DET B-O
data NOUN B-O
from ADP B-O
the DET B-O
cluster NOUN B-O
- PUNCT B-O
randomized VERB B-O
cross ADJ B-O
- PUNCT B-O
sectional ADJ B-O
Endoscopic PROPN B-LF
Quality PROPN I-LF
Improvement PROPN I-LF
Program-3 PROPN I-LF
( PUNCT B-O
EQUIP-3 PROPN B-AC
) PUNCT B-O
study NOUN B-O
( PUNCT B-O
Clinical PROPN B-O
Trials PROPN B-O
Registration PROPN B-O
: PUNCT B-O
NCT02325635 NUM B-O
) PUNCT B-O
that PRON B-O
ran VERB B-O
from ADP B-O
September PROPN B-O
2013 NUM B-O
until ADP B-O
January PROPN B-O
2015.[9 NUM B-O
] PUNCT B-O
The DET B-O
EQUIP-3 PROPN B-AC
study NOUN B-O
was AUX B-O
approved VERB B-O
by ADP B-O
the DET B-O
Mayo PROPN B-O
Clinic PROPN B-O
Institutional PROPN B-O
Review PROPN B-O
Board PROPN B-O
and CCONJ B-O
was AUX B-O
considered VERB B-O
minimal ADJ B-O
risk NOUN B-O
and CCONJ B-O
exempt ADJ B-O
from ADP B-O
patient NOUN B-O
- PUNCT B-O
level NOUN B-O
consent.[9 NOUN B-O
] PUNCT B-O
In ADP B-O
the DET B-O
EQUIP-3 PROPN B-AC
study NOUN B-O
centers NOUN B-O
were AUX B-O
randomized VERB B-O
, PUNCT B-O
after ADP B-O
a DET B-O
lead VERB B-O
- PUNCT B-O
in ADP B-O
phase NOUN B-O
, PUNCT B-O
to PART B-O
receive VERB B-O
a DET B-O
quality NOUN B-O
improvement NOUN B-O
program NOUN B-O
aimed VERB B-O
at ADP B-O
increasing VERB B-O
the DET B-O
ADR PROPN B-AC
or CCONJ B-O
no DET B-O
intervention NOUN B-O
. PUNCT B-O

Intracranial ADJ B-LF
pressure NOUN I-LF
( PUNCT B-O
ICP PROPN B-AC
) PUNCT B-O
monitoring NOUN B-O
is AUX B-O
necessary ADJ B-O
in ADP B-O
many ADJ B-O
clinical ADJ B-O
scenarios NOUN B-O
. PUNCT B-O

Prostate NOUN B-LF
cancer NOUN I-LF
( PUNCT B-O
PCa NOUN B-AC
) PUNCT B-O
poses VERB B-O
a DET B-O
major ADJ B-O
health NOUN B-O
concern NOUN B-O
in ADP B-O
men NOUN B-O
worldwide ADV B-O
. PUNCT B-O

This DET B-O
score NOUN B-O
was AUX B-O
called VERB B-O
the DET B-O
Perturbation PROPN B-LF
Score PROPN I-LF
( PUNCT B-O
PS PROPN B-AC
; PUNCT B-O
PScp PROPN B-O
, PUNCT B-O
d NOUN B-O
being AUX B-O
the DET B-O
perturbation NOUN B-O
experimented VERB B-O
by ADP B-O
pathway NOUN B-O
p NOUN B-O
during ADP B-O
the DET B-O
manifestation NOUN B-O
of ADP B-O
disease NOUN B-O
d NOUN B-O
on ADP B-O
cell NOUN B-O
type NOUN B-O
c NOUN B-O
) PUNCT B-O
. PUNCT B-O

The DET B-O
Charlson PROPN B-LF
Comorbidity PROPN I-LF
Index PROPN I-LF
( PUNCT B-O
CCI PROPN B-AC
) PUNCT B-O
was AUX B-O
calculated VERB B-O
electronically.[22 PUNCT B-O
] PUNCT B-O
Sepsis NOUN B-O
was AUX B-O
identified VERB B-O
using VERB B-O
a DET B-O
previously ADV B-O
- PUNCT B-O
validated VERB B-O
electronic ADJ B-O
algorithm.[23 NOUN B-O
] PUNCT B-O
Relevant ADJ B-O
cardiovascular ADJ B-O
hospital NOUN B-O
discharge NOUN B-O
diagnoses NOUN B-O
were AUX B-O
determined VERB B-O
using VERB B-O
ICD-9 PROPN B-O
diagnostic ADJ B-O
codes NOUN B-O
. PUNCT B-O

To PART B-O
converge VERB B-O
on ADP B-O
stable ADJ B-O
model NOUN B-O
output NOUN B-O
, PUNCT B-O
we PRON B-O
run VERB B-O
a DET B-O
simulated VERB B-O
cohort NOUN B-O
of ADP B-O
1 NUM B-O
million NUM B-O
patients NOUN B-O
infected VERB B-O
with ADP B-O
HIV PROPN B-O
. PUNCT B-O
Because SCONJ B-O
the DET B-O
cohort NOUN B-O
size NOUN B-O
can AUX B-O
be AUX B-O
varied VERB B-O
in ADP B-O
the DET B-O
simulation NOUN B-O
— PUNCT B-O
i.e. X B-O
, PUNCT B-O
we PRON B-O
might AUX B-O
also ADV B-O
simulate VERB B-O
2 NUM B-O
million NUM B-O
or CCONJ B-O
5 NUM B-O
million NUM B-O
patients—95 NOUN B-O
% NOUN B-O
confidence NOUN B-O
intervals NOUN B-O
and CCONJ B-O
standard ADJ B-LF
deviations NOUN I-LF
( PUNCT B-O
SDs NOUN B-AC
) PUNCT B-O
do AUX B-O
not PART B-O
adequately ADV B-O
capture VERB B-O
uncertainty NOUN B-O
in ADP B-O
simulation NOUN B-O
modeling NOUN B-O
. PUNCT B-O

LRI NOUN B-AC
, PUNCT B-O
lower ADJ B-LF
respiratory ADJ I-LF
infection NOUN I-LF
. PUNCT B-O

FWP PROPN B-AC
mechanism NOUN B-O
of ADP B-O
action NOUN B-O
could AUX B-O
possibly ADV B-O
be AUX B-O
mediated VERB B-O
by ADP B-O
an DET B-O
elevation NOUN B-O
of ADP B-O
GSH PROPN B-O
concentration NOUN B-O
and CCONJ B-O
a DET B-O
decreased VERB B-O
glutathione NOUN B-LF
redox NOUN I-LF
ratio NOUN I-LF
( PUNCT B-O
GSSG NOUN B-AC
/ SYM B-AC
GSH PROPN B-AC
) PUNCT B-O
ratio NOUN B-O
which PRON B-O
leads VERB B-O
to ADP B-O
a DET B-O
suppression NOUN B-O
of ADP B-O
OxS PROPN B-AC
and CCONJ B-O
the DET B-O
decreased VERB B-O
release NOUN B-O
of ADP B-O
8 NUM B-AC
- PUNCT B-AC
EPI NOUN B-AC
. PUNCT B-O
Hydrolyzed VERB B-O
whey NOUN B-O
protein NOUN B-O
isolate NOUN B-O
can AUX B-O
increase VERB B-O
intracellular ADJ B-O
glutathione NOUN B-O
level NOUN B-O
in ADP B-O
human ADJ B-O
prostate NOUN B-O
epithelial ADJ B-O
cell NOUN B-O
line NOUN B-O
and CCONJ B-O
protect VERB B-O
form NOUN B-O
oxidant NOUN B-O
induced VERB B-O
cell NOUN B-O
death[16 NOUN B-O
] PUNCT B-O
. PUNCT B-O

Twenty NUM B-O
- PUNCT B-O
one NUM B-O
studies NOUN B-O
( PUNCT B-O
44 NUM B-O
% PUNCT B-O
) PUNCT B-O
analyzed VERB B-O
birthweight NOUN B-O
, PUNCT B-O
low ADJ B-LF
birthweight NOUN I-LF
( PUNCT B-O
LBW PROPN B-AC
) PUNCT B-O
, PUNCT B-O
and CCONJ B-O
small ADJ B-O
for ADP B-O
gestational ADJ B-O
age NOUN B-O
. PUNCT B-O