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README.md
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license: cc-by-4.0
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library_name: scvi-tools
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tags:
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- biology
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- genomics
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- single-cell
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- model_cls_name:SCVI
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- scvi_version:1.
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- anndata_version:0.
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- modality:rna
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- tissue:
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- annotated:True
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---
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Tabula Sapiens is a benchmark, first-draft human cell atlas of nearly 500,000 cells from 24 organs of 15 normal human subjects.
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```json
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{
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"n_hidden": 128,
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}
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```
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```json
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{
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"layer": null,
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}
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```
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| n_labels | 6 |
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| n_latent_qzm | 20 |
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| n_latent_qzv | 20 |
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| n_vars | 4000 |
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**model_data_registry**:
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| Registry Key | scvi-tools Location |
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|-------------------|--------------------------------------|
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**
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# Training data
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<!-- If your model is not uploaded with any data (e.g., minified data) on the Model Hub, then make
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sure to provide this field if you want users to be able to access your training data. See the
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documentation for details. -->
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Training code url: N/A
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# References
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The Tabula Sapiens Consortium. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science, May 2022. doi:10.1126/science.abl4896
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---
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library_name: scvi-tools
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license: cc-by-4.0
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tags:
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- biology
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- genomics
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- single-cell
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- model_cls_name:SCVI
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- scvi_version:1.2.0
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- anndata_version:0.11.1
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- modality:rna
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- tissue:various
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- annotated:True
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---
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ScVI is a variational inference model for single-cell RNA-seq data that can learn an underlying
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latent space, integrate technical batches and impute dropouts.
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The learned low-dimensional latent representation of the data can be used for visualization and
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clustering.
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scVI takes as input a scRNA-seq gene expression matrix with cells and genes.
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We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_guide/models/scvi.html).
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- See our original manuscript for further details of the model:
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[scVI manuscript](https://www.nature.com/articles/s41592-018-0229-2).
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- See our manuscript on [scvi-hub](https://www.biorxiv.org/content/10.1101/2024.03.01.582887v2) how
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to leverage pre-trained models.
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This model can be used for fine tuning on new data using our Arches framework:
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[Arches tutorial](https://docs.scvi-tools.org/en/1.0.0/tutorials/notebooks/scarches_scvi_tools.html).
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# Model Description
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Tabula Sapiens is a benchmark, first-draft human cell atlas of nearly 500,000 cells from 24 organs of 15 normal human subjects.
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# Metrics
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We provide here key performance metrics for the uploaded model, if provided by the data uploader.
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<details>
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<summary><strong>Coefficient of variation</strong></summary>
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The cell-wise coefficient of variation summarizes how well variation between different cells is
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preserved by the generated model expression. Below a squared Pearson correlation coefficient of 0.4
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, we would recommend not to use generated data for downstream analysis, while the generated latent
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space might still be useful for analysis.
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**Cell-wise Coefficient of Variation**:
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Not provided by uploader
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The gene-wise coefficient of variation summarizes how well variation between different genes is
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preserved by the generated model expression. This value is usually quite high.
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**Gene-wise Coefficient of Variation**:
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Not provided by uploader
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</details>
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<details>
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<summary><strong>Differential expression metric</strong></summary>
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The differential expression metric provides a summary of the differential expression analysis
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between cell types or input clusters. We provide here the F1-score, Pearson Correlation
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Coefficient of Log-Foldchanges, Spearman Correlation Coefficient, and Area Under the Precision
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Recall Curve (AUPRC) for the differential expression analysis using Wilcoxon Rank Sum test for each
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cell-type.
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**Differential expression**:
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Not provided by uploader
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</details>
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# Model Properties
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We provide here key parameters used to setup and train the model.
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<details>
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<summary><strong>Model Parameters</strong></summary>
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These provide the settings to setup the original model:
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```json
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{
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"n_hidden": 128,
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}
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```
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</details>
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<details>
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<summary><strong>Setup Data Arguments</strong></summary>
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Arguments passed to setup_anndata of the original model:
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```json
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{
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"layer": null,
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}
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```
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</details>
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<details>
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<summary><strong>Data Registry</strong></summary>
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Registry elements for AnnData manager:
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|[1m [0m[1m Registry Key [0m[1m [0m|[1m [0m[1m scvi-tools Location [0m[1m [0m|
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|-------------------|--------------------------------------|
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|[94m [0m[94m X [0m[94m [0m|[35m [0m[35m adata.X [0m[35m [0m|
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|[94m [0m[94m batch [0m[94m [0m|[35m [0m[35m adata.obs['_scvi_batch'] [0m[35m [0m|
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|[94m [0m[94m labels [0m[94m [0m|[35m [0m[35m adata.obs['_scvi_labels'] [0m[35m [0m|
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|[94m [0m[94m latent_qzm [0m[94m [0m|[35m [0m[35m adata.obsm['scvi_latent_qzm'] [0m[35m [0m|
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|[94m [0m[94m latent_qzv [0m[94m [0m|[35m [0m[35m adata.obsm['scvi_latent_qzv'] [0m[35m [0m|
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|[94m [0m[94m minify_type [0m[94m [0m|[35m [0m[35madata.uns['_scvi_adata_minify_type'][0m[35m [0m|
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|[94m [0m[94mobserved_lib_size[0m[94m [0m|[35m [0m[35m adata.obs['observed_lib_size'] [0m[35m [0m|
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- **Data is Minified**: False
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</details>
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<details>
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<summary><strong>Summary Statistics</strong></summary>
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|[1m [0m[1m Summary Stat Key [0m[1m [0m|[1m [0m[1mValue[0m[1m [0m|
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|--------------------------|-------|
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|[94m [0m[94m n_batch [0m[94m [0m|[35m [0m[35m 2 [0m[35m [0m|
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|[94m [0m[94m n_cells [0m[94m [0m|[35m [0m[35m11505[0m[35m [0m|
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|[94m [0m[94mn_extra_categorical_covs[0m[94m [0m|[35m [0m[35m 0 [0m[35m [0m|
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|[94m [0m[94mn_extra_continuous_covs [0m[94m [0m|[35m [0m[35m 0 [0m[35m [0m|
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|[94m [0m[94m n_labels [0m[94m [0m|[35m [0m[35m 6 [0m[35m [0m|
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|[94m [0m[94m n_latent_qzm [0m[94m [0m|[35m [0m[35m 20 [0m[35m [0m|
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|[94m [0m[94m n_latent_qzv [0m[94m [0m|[35m [0m[35m 20 [0m[35m [0m|
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|[94m [0m[94m n_vars [0m[94m [0m|[35m [0m[35m3000 [0m[35m [0m|
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</details>
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<details>
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<summary><strong>Training</strong></summary>
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<!-- If your model is not uploaded with any data (e.g., minified data) on the Model Hub, then make
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sure to provide this field if you want users to be able to access your training data. See the
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scvi-tools documentation for details. -->
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**Training data url**: Not provided by uploader
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If provided by the original uploader, for those interested in understanding or replicating the
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training process, the code is available at the link below.
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**Training Code URL**: Not provided by uploader
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</details>
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# References
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The Tabula Sapiens Consortium. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science, May 2022. doi:10.1126/science.abl4896
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