Datasets:

HHS-Official
/

examination-of-sars-cov-2-serological-test-results

Sample # int64 1 204	PCR confirmed stringclasses 2 values	Abbott Reactivity stringclasses 2 values	Ortho Reactivity stringclasses 2 values	In-House CDC ELISA Reactivity stringclasses 2 values	Abbott S/C Values float64 0.02 7.94	Abbott S/C Values (Log10) float64 -1.7 0.9	Ortho Index Values float64 0.01 660	Ortho Index Values (Log10) float64 -2 2.82	In-House CDC ELISA S/T Values float64 0.04 3.92	In-House CDC ELISA S/T Values (Log10) float64 -1.43 0.59	mNT TITER float64 10 5.95k	mNT TITER (Log10) float64 1 3.77	sVNT % Inhibition float64 0 0.96
1	Pos	Reactive	Reactive	Reactive	3.48	0.5416	10.1	1.0043	1.2992	0.1137	18	1.2553	0.4
2	Pos	Reactive	Reactive	Reactive	5.08	0.7059	289	2.4609	3.3092	0.5197	233	2.3674	0.81
3	Pos	Reactive	Reactive	Reactive	6.86	0.8363	354	2.549	3.4608	0.5392	2,198	3.342	0.95
4	Pos	Reactive	Reactive	Reactive	3.91	0.5922	51.1	1.7084	2.7525	0.4397	27	1.4314	0.56
5	Pos	Reactive	Reactive	Reactive	5.16	0.7126	242	2.3838	3.1808	0.5025	524	2.7193	0.8
6	Pos	Reactive	Reactive	Reactive	1.61	0.2068	26.3	1.42	2.1333	0.3291	57	1.7559	0.41
7	Pos	Reactive	Reactive	Reactive	6.44	0.8089	129	2.1106	3.1508	0.4984	385	2.5855	0.72
8	Pos	Reactive	Reactive	Reactive	6.79	0.8319	74.3	1.871	2.9683	0.4725	310	2.4914	0.72
9	Pos	Reactive	Reactive	Reactive	6.9	0.8388	123	2.0899	3.245	0.5112	158	2.1987	0.78
10	Pos	Reactive	Reactive	Reactive	2.65	0.4232	106	2.0253	3.3042	0.5191	176	2.2455	0.77
11	Pos	Reactive	Reactive	Reactive	5.06	0.7042	178	2.2504	3.5958	0.5558	476	2.6776	0.87
12	Pos	Reactive	Reactive	Reactive	7.57	0.8791	119	2.0755	3.5867	0.5547	901	2.9547	0.86
13	Pos	Reactive	Reactive	Reactive	3.68	0.5658	15.8	1.1987	1.0333	0.0142	32	1.5051	0.28
14	Pos	Reactive	Reactive	Reactive	7.76	0.8899	371	2.5694	3.5792	0.5538	5,954	3.7748	0.93
15	Pos	Reactive	Reactive	Reactive	5	0.699	32.4	1.5105	2.9067	0.4634	267	2.4265	0.59
16	Pos	Reactive	Reactive	Reactive	2.53	0.4031	62.7	1.7973	3.0575	0.4854	340	2.5315	0.73
17	Pos	Non-reactive	Non-reactive	Non-reactive	0.05	-1.301	0.03	-1.5229	0.1033	-0.9859	10	1	0
18	Pos	Reactive	Reactive	Reactive	6.3	0.7993	70.9	1.8506	3.4108	0.5329	1,030	3.0128	0.8
19	Pos	Reactive	Reactive	Reactive	5.71	0.7566	14.4	1.1584	3.1217	0.4944	623	2.7945	0.44
20	Pos	Non-reactive	Non-reactive	Non-reactive	0.09	-1.0458	0.02	-1.699	0.0592	-1.2277	10	1	0.08
21	Pos	Reactive	Reactive	Reactive	6.78	0.8312	463	2.6656	3.5625	0.5518	5,108	3.7083	0.92
22	Pos	Reactive	Reactive	Reactive	3.95	0.5966	55.3	1.7427	2.2558	0.3533	30	1.4771	0.43
23	Pos	Reactive	Reactive	Reactive	4.77	0.6785	37	1.5682	3.6825	0.5661	535	2.7284	0.7
24	Pos	Reactive	Reactive	Reactive	3.63	0.5599	226	2.3541	3.2092	0.5064	42	1.6232	0.75
25	Pos	Reactive	Reactive	Reactive	6.53	0.8149	110	2.0414	3.8058	0.5804	3,520	3.5465	0.93
26	Pos	Reactive	Reactive	Reactive	4.32	0.6355	16	1.2041	1.8217	0.2605	45	1.6532	0.44
27	Pos	Reactive	Reactive	Reactive	4.44	0.6474	290	2.4624	3.4308	0.5354	640	2.8062	0.89
28	Pos	Reactive	Reactive	Reactive	5.31	0.7251	212	2.3263	3.4025	0.5318	770	2.8865	0.86
29	Pos	Reactive	Reactive	Reactive	4.49	0.6522	3.31	0.5198	1.7833	0.2512	20	1.301	0.34
30	Pos	Reactive	Reactive	Reactive	4.66	0.6684	266	2.4249	3.6025	0.5566	1,269	3.1035	0.91
31	Pos	Reactive	Reactive	Reactive	5.59	0.7474	109	2.0374	3.7525	0.5743	1,385	3.1414	0.85
32	Neg	Non-reactive	Non-reactive	Non-reactive	0.52	-0.284	0.02	-1.699	0.265	-0.5768	10	1	0.07
33	Neg	Non-reactive	Non-reactive	Non-reactive	0.38	-0.4202	0.02	-1.699	0.0958	-1.0186	10	1	0.08
34	Neg	Non-reactive	Non-reactive	Non-reactive	0.42	-0.3768	0.03	-1.5229	0.1808	-0.7428	10	1	0.08
35	Neg	Non-reactive	Non-reactive	Non-reactive	0.47	-0.3279	0.02	-1.699	0.2775	-0.5567	10	1	0.1
36	Neg	Non-reactive	Non-reactive	Non-reactive	0.59	-0.2291	0.02	-1.699	0.2225	-0.6527	10	1	0.1
37	Neg	Non-reactive	Non-reactive	Non-reactive	0.58	-0.2366	0.02	-1.699	0.8067	-0.0933	10	1	0.18
38	Neg	Non-reactive	Non-reactive	Non-reactive	0.31	-0.5086	0.03	-1.5229	0.2983	-0.5253	10	1	0.13
39	Neg	Non-reactive	Non-reactive	Non-reactive	0.41	-0.3872	0.02	-1.699	0.17	-0.7696	10	1	0.12
40	Neg	Non-reactive	Non-reactive	Non-reactive	1.36	0.1335	0.02	-1.699	0.4258	-0.3708	10	1	0.11
41	Neg	Non-reactive	Non-reactive	Non-reactive	0.29	-0.5376	0.02	-1.699	0.225	-0.6478	10	1	0.11
42	Neg	Non-reactive	Non-reactive	Non-reactive	0.38	-0.4202	0.02	-1.699	0.2008	-0.6972	10	1	0.09
43	Neg	Non-reactive	Non-reactive	Non-reactive	0.35	-0.4559	0.02	-1.699	0.1258	-0.9003	10	1	0.14
44	Neg	Non-reactive	Non-reactive	Non-reactive	0.42	-0.3768	0.02	-1.699	0.2475	-0.6064	10	1	0.14
45	Neg	Non-reactive	Non-reactive	Reactive	0.46	-0.3372	0.07	-1.1549	1.02	0.0086	10	1	0.19
46	Neg	Non-reactive	Non-reactive	Non-reactive	0.34	-0.4685	0.02	-1.699	0.1875	-0.727	10	1	0.16
47	Neg	Non-reactive	Non-reactive	Non-reactive	0.39	-0.4089	0.03	-1.5229	0.1642	-0.7846	10	1	0.19
48	Neg	Non-reactive	Non-reactive	Non-reactive	0.45	-0.3468	0.03	-1.5229	0.1925	-0.7156	10	1	0.2
49	Neg	Non-reactive	Non-reactive	Non-reactive	0.21	-0.6778	0.03	-1.5229	0.22	-0.6576	10	1	0.15
50	Neg	Non-reactive	Non-reactive	Non-reactive	0.46	-0.3372	0.03	-1.5229	0.185	-0.7328	10	1	0.09
51	Neg	Non-reactive	Non-reactive	Non-reactive	0.58	-0.2366	0.05	-1.301	0.2433	-0.6139	10	1	0.09
52	Pos	Non-reactive	Non-reactive	Non-reactive	0.55	-0.2596	0.01	-2	0.0967	-1.0146	10	1	0.15
53	Pos	Reactive	Reactive	Reactive	5.38	0.7308	5.28	0.7226	2.5658	0.4092	47	1.6721	0.52
54	Pos	Reactive	Reactive	Reactive	7.37	0.8675	382	2.5821	3.85	0.5855	622	2.7938	0.94
55	Pos	Reactive	Reactive	Reactive	4.85	0.6857	22.3	1.3483	3.715	0.57	685	2.8357	0.82
56	Pos	Reactive	Reactive	Reactive	1.46	0.1644	53.8	1.7308	3.3067	0.5194	392	2.5933	0.66
57	Pos	Reactive	Reactive	Reactive	3.38	0.5289	124	2.0934	3.19	0.5038	462.7	2.6653	0.82
58	Pos	Reactive	Reactive	Reactive	5.77	0.7612	271	2.433	3.2058	0.5059	893.9	2.9513	0.87
59	Pos	Reactive	Reactive	Reactive	5.66	0.7528	22.8	1.3579	2.7917	0.4459	125.9	2.1	0.53
60	Pos	Reactive	Reactive	Reactive	3.42	0.534	62.2	1.7938	3.0192	0.4799	50.86	1.7064	0.69
61	Pos	Reactive	Reactive	Reactive	3.99	0.601	51.2	1.7093	2.9742	0.4734	170.2	2.231	0.67
62	Pos	Reactive	Reactive	Reactive	4.14	0.617	74.6	1.8727	3.2225	0.5082	165	2.2175	0.59
63	Pos	Reactive	Reactive	Reactive	5.7	0.7559	157	2.1959	3.3575	0.526	319	2.5038	0.81
64	Pos	Reactive	Reactive	Reactive	4.46	0.6493	118	2.0719	3.1517	0.4985	546	2.7372	0.83
65	Pos	Reactive	Reactive	Reactive	6.91	0.8395	447	2.6503	3.45	0.5378	1,374	3.138	0.91
66	Pos	Reactive	Reactive	Reactive	4.02	0.6042	229	2.3598	3.2917	0.5174	656	2.8169	0.86
67	Pos	Reactive	Reactive	Reactive	4.1	0.6128	147	2.1673	3.74	0.5729	633	2.8014	0.85
68	Pos	Reactive	Reactive	Reactive	5.94	0.7738	186	2.2695	3.4042	0.532	2,071	3.3162	0.9
69	Pos	Reactive	Reactive	Reactive	3.32	0.5211	65.4	1.8156	3.3442	0.5243	522	2.7177	0.81
70	Pos	Reactive	Reactive	Reactive	2.28	0.3579	63.5	1.8028	2.8975	0.462	19	1.2788	0.5
71	Pos	Reactive	Reactive	Reactive	5.58	0.7466	186	2.2695	3.31	0.5198	687	2.837	0.84
72	Neg	Non-reactive	Non-reactive	Non-reactive	0.22	-0.6576	0.03	-1.5229	0.2042	-0.6899	10	1	0.16
73	Neg	Non-reactive	Non-reactive	Non-reactive	0.19	-0.7212	0.07	-1.1549	0.07	-1.1549	10	1	0.16
74	Neg	Non-reactive	Non-reactive	Non-reactive	0.25	-0.6021	0.03	-1.5229	0.1583	-0.8005	10	1	0.22
75	Neg	Non-reactive	Non-reactive	Non-reactive	0.14	-0.8539	0.03	-1.5229	0.2717	-0.5659	10	1	0.25
76	Neg	Non-reactive	Non-reactive	Non-reactive	0.22	-0.6576	0.02	-1.699	0.1592	-0.7981	10	1	0.17
77	Neg	Non-reactive	Non-reactive	Non-reactive	0.21	-0.6778	0.94	-0.0269	0.1325	-0.8778	10	1	0.13
78	Neg	Non-reactive	Non-reactive	Non-reactive	0.1	-1	0.02	-1.699	0.1	-1	10	1	0.14
79	Neg	Non-reactive	Non-reactive	Non-reactive	0.2	-0.699	0.02	-1.699	0.1692	-0.7716	10	1	0.2
80	Neg	Non-reactive	Non-reactive	Non-reactive	0.3	-0.5229	0.03	-1.5229	0.16	-0.7959	10	1	0.21
81	Neg	Non-reactive	Non-reactive	Non-reactive	0.32	-0.4949	0.02	-1.699	0.1075	-0.9686	10	1	0.23
82	Neg	Non-reactive	Non-reactive	Non-reactive	0.17	-0.7696	0.02	-1.699	0.095	-1.0223	10	1	0.25
83	Neg	Non-reactive	Non-reactive	Non-reactive	0.17	-0.7696	0.02	-1.699	0.18	-0.7447	10	1	0.24
84	Neg	Non-reactive	Non-reactive	Non-reactive	0.15	-0.8239	0.02	-1.699	0.1908	-0.7194	10	1	0.2
85	Neg	Non-reactive	Non-reactive	Non-reactive	0.2	-0.699	0.02	-1.699	0.1517	-0.819	10	1	0.11
86	Neg	Non-reactive	Non-reactive	Non-reactive	0.49	-0.3098	0.02	-1.699	0.1367	-0.8642	10	1	0.12
87	Neg	Non-reactive	Non-reactive	Non-reactive	0.21	-0.6778	0.02	-1.699	0.0892	-1.0496	10	1	0.21
88	Neg	Non-reactive	Non-reactive	Non-reactive	0.2	-0.699	0.02	-1.699	0.3792	-0.4211	10	1	0.27
89	Neg	Non-reactive	Non-reactive	Non-reactive	0.29	-0.5376	0.02	-1.699	0.1308	-0.8834	10	1	0.28
90	Neg	Non-reactive	Non-reactive	Non-reactive	0.15	-0.8239	0.02	-1.699	0.095	-1.0223	10	1	0.29
91	Neg	Non-reactive	Non-reactive	Non-reactive	0.09	-1.0458	0.02	-1.699	0.0742	-1.1296	10	1	0
92	Neg	Non-reactive	Non-reactive	Non-reactive	0.27	-0.5686	0.02	-1.699	0.4408	-0.3558	10	1	0.26
93	Neg	Non-reactive	Non-reactive	Non-reactive	0.11	-0.9586	0.02	-1.699	0.1308	-0.8834	10	1	0.25
94	Neg	Non-reactive	Non-reactive	Non-reactive	0.13	-0.8861	0.02	-1.699	0.1092	-0.9618	10	1	0.16
95	Neg	Non-reactive	Non-reactive	Non-reactive	0.17	-0.7696	0.02	-1.699	0.58	-0.2366	10	1	0.17
96	Neg	Non-reactive	Non-reactive	Non-reactive	0.2	-0.699	0.02	-1.699	0.14	-0.8539	10	1	0.26
97	Neg	Non-reactive	Non-reactive	Non-reactive	0.15	-0.8239	0.02	-1.699	0.1975	-0.7044	10	1	0.28
98	Neg	Non-reactive	Non-reactive	Non-reactive	0.11	-0.9586	0.11	-0.9586	0.1092	-0.9618	10	1	0.34
99	Neg	Non-reactive	Non-reactive	Non-reactive	0.1	-1	0.02	-1.699	0.3883	-0.4108	10	1	0.27
100	Neg	Non-reactive	Non-reactive	Non-reactive	0.26	-0.585	0.02	-1.699	0.1267	-0.8972	10	1	0.28

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Examination of SARS-CoV-2 serological test results from multiple commercial and laboratory platforms with an in-house serum panel

Description

Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) is a novel human coronavirus that was identified in 2019. SARS-CoV-2 infection results in an acute, severe respiratory disease called coronavirus disease 2019 (COVID-19). The emergence and rapid spread of SARS-CoV-2 has led to a global public health crisis, which continues to affect populations across the globe. Real time reverse transcription polymerase chain reaction (rRT-PCR) is the reference standard test for COVID-19 diagnosis. Serological tests are valuable tools for serosurveillance programs and establishing correlates of protection from disease. This study evaluated the performance of one in-house enzyme linked immunosorbent assay (ELISA) utilizing the pre-fusion stabilized ectodomain of SARS-CoV-2 spike (S), two commercially available chemiluminescence assays Ortho VITROS Immunodiagnostic Products Anti-SARS-CoV-2 Total Reagent Pack and Abbott SARS-CoV-2 IgG assay and one commercially available Surrogate Virus Neutralization Test (sVNT), GenScript USA Inc., cPass SARS-CoV-2 Neutralization Antibody Detection Kit for the detection of SARS-CoV-2 specific antibodies. Using a panel of rRT-PCR confirmed COVID-19 patients’ sera and a negative control group as a reference standard, all three immunoassays demonstrated high comparable positivity rates and low discordant rates. All three immunoassays were highly sensitive with estimated sensitivities ranging from 95.4%-96.6%. ROC curve analysis indicated that all three immunoassays had high diagnostic accuracies with area under the curve (AUC) values ranging from 0.9698-0.9807. High positive correlation was demonstrated among the conventional microneutralization test (MNT) titers and the sVNT inhibition percent values. Our study indicates that independent evaluations are necessary to optimize the overall utility and the interpretation of the results of serological tests. Overall, we demonstrate that all serological tests evaluated in this study are suitable for the detection of SARS-CoV-2 antibodies.

Dataset Details

Publisher: Centers for Disease Control and Prevention
Last Modified: 2025-02-23
Contact: CDC-INFO ([email protected])

Source

Original data can be found at: https://data.cdc.gov/d/hhvg-83jq

Usage

You can load this dataset using:

from datasets import load_dataset
 dataset = load_dataset('HHS-Official/examination-of-sars-cov-2-serological-test-results')

License

This dataset is licensed under https://www.usa.gov/government-works

Downloads last month: 40

Size of downloaded dataset files:

19.2 kB

Size of the auto-converted Parquet files:

18.1 kB

Number of rows:

204