screen_file
string | organism
string | perturbation
string | gene
string | cell
string | phenotype
string | hit
int64 | benchmark_type
string | prompt
string | gene_context
string |
|---|---|---|---|---|---|---|---|---|---|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Gart
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Gart in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Gart (phosphoribosylglycinamide formyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, adenine biosynthetic process, brainstem development, cerebellum development, cerebral cortex development, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process; MF: ATP binding, catalytic activity, ligase activity, ligase activity, forming carbon-nitrogen bonds, metal ion binding, nucleotide binding, phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity, phosphoribosylglycinamide formyltransferase activity, transferase activity; CC: cytosol
Pathways: 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, One carbon pool by folate - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, superpathway of 5-aminoimidazole ribonucleotide biosynthesis, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
UniProt: Q64737
Entrez ID: 14450
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Bap1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Bap1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Bap1 (Brca1 associated protein 1)
Type: protein-coding
Summary: Enables chromatin DNA binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hematopoietic stem cell homeostasis; and myeloid cell differentiation. Acts upstream of or within macrophage homeostasis; regulation of cytokine production involved in inflammatory response; and regulation of inflammatory response. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of PR-DUB complex. Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; decidua; gonad; mammary gland; and trophectoderm. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in basal cell carcinoma; extrahepatic bile duct adenocarcinoma; and uveal melanoma. Orthologous to human BAP1 (BRCA1 associated deubiquitinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, cell population proliferation, chromatin organization, common myeloid progenitor cell proliferation, erythrocyte differentiation, erythrocyte maturation, gene expression, granulocyte differentiation, hematopoietic stem cell homeostasis, heterochromatin formation, in utero embryonic development, leukocyte proliferation, macrophage homeostasis, mitotic cell cycle, monoubiquitinated protein deubiquitination, myeloid cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, neuron cellular homeostasis, neutrophil differentiation, nucleate erythrocyte differentiation, platelet morphogenesis, protein K48-linked deubiquitination, protein deubiquitination, proteolysis, regulation of cell cycle, regulation of cell growth, regulation of cytokine production involved in inflammatory response, regulation of gene expression, regulation of inflammatory response, thrombocyte differentiation, tissue homeostasis, ubiquitin-dependent protein catabolic process; MF: chromatin DNA binding, chromatin binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, histone H2A deubiquitinase activity, hydrolase activity, peptidase activity, protein binding; CC: PR-DUB complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, Metabolism of proteins, Post-translational protein modification, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, UCH proteinases
UniProt: Q99PU7
Entrez ID: 104416
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tkt
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tkt in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tkt (transketolase)
Type: protein-coding
Summary: This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: D-xylulose 5-phosphate biosynthetic process, glyceraldehyde-3-phosphate biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch, regulation of growth; MF: calcium ion binding, carbohydrate binding, magnesium ion binding, metal ion binding, monosaccharide binding, protein homodimerization activity, thiamine pyrophosphate binding, transferase activity, transketolase activity; CC: cytoplasm, cytosol, endoplasmic reticulum membrane, myelin sheath, nuclear body, nucleoplasm, peroxisome
Pathways: (deoxy)ribose phosphate degradation, Insulin effects increased synthesis of Xylulose-5-Phosphate, Integration of energy metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: P40142
Entrez ID: 21881
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppat
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppat in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppat (phosphoribosyl pyrophosphate amidotransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, L-glutamine catabolic process, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process; MF: 4 iron, 4 sulfur cluster binding, amidophosphoribosyltransferase activity, catalytic activity, glycosyltransferase activity, identical protein binding, iron-sulfur cluster binding, metal ion binding, transferase activity
Pathways: 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, superpathway of 5-aminoimidazole ribonucleotide biosynthesis
UniProt: Q8CIH9
Entrez ID: 231327
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mthfd1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mthfd1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mthfd1 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase)
Type: protein-coding
Summary: This gene encodes a trifunctional cytoplasmic enzyme. The encoded protein functions as a methylenetetrahydrofolate dehydrogenase, a methenyltetrahydrofolate cyclohydrolase, and a formyltetrahydrofolate synthase. The encoded enzyme functions in de novo synthesis of purines and thymidylate and in regeneration of methionine from homocysteine. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: 10-formyltetrahydrofolate biosynthetic process, amino acid biosynthetic process, folic acid metabolic process, heart development, methionine biosynthetic process, methionine metabolic process, neural tube closure, neutrophil homeostasis, one-carbon metabolic process, purine nucleotide biosynthetic process, purine ribonucleotide biosynthetic process, serine family amino acid metabolic process, somite development, tetrahydrofolate interconversion, transsulfuration; MF: ATP binding, catalytic activity, formate-tetrahydrofolate ligase activity, hydrolase activity, ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NADP+) activity, nucleotide binding, oxidoreductase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate polyglutamylation, folate transformations I, folate transformations II (plants), histidine degradation III, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
UniProt: Q922D8
Entrez ID: 108156
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl27a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl27a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl27a (ribosomal protein L27A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Post-translational protein modification, Protein hydroxylation, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14115
Entrez ID: 26451
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif4a1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif4a1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif4a1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, positive regulation of transcription by RNA polymerase II, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, membrane, nuclear stress granule, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, ISG15 antiviral mechanism, Immune System, Interferon Signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of RNA, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: P60843
Entrez ID: 13681
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl8
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl8 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl8 (ribosomal protein L8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: 5.8S rRNA binding, RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Post-translational protein modification, Protein hydroxylation, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62918
Entrez ID: 26961
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pfas
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pfas in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pfas (phosphoribosylformylglycinamidine synthase (FGAR amidotransferase))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, anterior head development, glutamine metabolic process, purine nucleotide biosynthetic process, response to xenobiotic stimulus; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, phosphoribosylformylglycinamidine synthase activity; CC: cytoplasm
Pathways: 5-aminoimidazole ribonucleotide biosynthesis I, 5-aminoimidazole ribonucleotide biosynthesis II, Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Purine metabolism - Mus musculus (mouse), Purine ribonucleoside monophosphate biosynthesis, superpathway of 5-aminoimidazole ribonucleotide biosynthesis
UniProt: Q5SUR0
Entrez ID: 237823
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps3 (ribosomal protein S3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, base-excision repair, cell division, cellular response to hydrogen peroxide, cellular response to reactive oxygen species, cellular response to tumor necrosis factor, chromosome segregation, cytoplasmic translation, negative regulation of DNA repair, negative regulation of protein ubiquitination, negative regulation of translation, positive regulation of DNA repair, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of activated T cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of base-excision repair, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of microtubule polymerization, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein-containing complex assembly, regulation of apoptotic process, regulation of translation, response to TNF agonist, spindle assembly, translation; MF: DNA binding, DNA endonuclease activity, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription factor binding, Hsp70 protein binding, Hsp90 protein binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, damaged DNA binding, enzyme binding, kinase binding, lyase activity, mRNA binding, microtubule binding, oxidized purine DNA binding, oxidized pyrimidine DNA binding, protein binding, protein kinase A binding, protein kinase binding, protein-containing complex binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, supercoiled DNA binding, tubulin binding, ubiquitin-like protein conjugating enzyme binding; CC: NF-kappaB complex, cytoplasm, cytoskeleton, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, dendrite, endoplasmic reticulum, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, mitotic spindle, nucleolus, nucleus, plasma membrane, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome, ruffle membrane, small ribosomal subunit, spindle, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Salmonella infection - Mus musculus (mouse), Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62908
Entrez ID: 27050
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps3a1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps3a1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps3a1 (ribosomal protein S3A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cytoplasmic translation, negative regulation of apoptotic process, ribosomal small subunit biogenesis, translation; MF: mRNA 5'-UTR binding, mRNA binding, protein binding, structural constituent of ribosome, translation initiation factor binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97351
Entrez ID: 20091
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpe
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpe in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpe (ribulose-5-phosphate-3-epimerase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch; MF: D-ribulose-phosphate 3-epimerase activity, carbohydrate binding, identical protein binding, isomerase activity, metal ion binding, monosaccharide binding, protein homodimerization activity, racemase and epimerase activity, acting on carbohydrates and derivatives; CC: cytosol
Pathways: Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose and glucuronate interconversions - Mus musculus (mouse), Pentose phosphate pathway, Pentose phosphate pathway - Mus musculus (mouse), pentose phosphate pathway, pentose phosphate pathway (non-oxidative branch)
UniProt: Q8VEE0
Entrez ID: 66646
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mocs3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mocs3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mocs3 (molybdenum cofactor synthesis 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Mo-molybdopterin cofactor biosynthetic process, molybdopterin cofactor biosynthetic process, protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: ATP binding, URM1 activating enzyme activity, adenylyltransferase activity, catalytic activity, metal ion binding, molybdopterin-synthase adenylyltransferase activity, molybdopterin-synthase sulfurtransferase activity, nucleotide binding, nucleotidyltransferase activity, sulfurtransferase activity, thiosulfate-cyanide sulfurtransferase activity, transferase activity, ubiquitin-like modifier activating enzyme activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Molybdenum cofactor biosynthesis, Sulfur relay system - Mus musculus (mouse)
UniProt: A2BDX3
Entrez ID: 69372
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Umps
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Umps in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Umps (uridine monophosphate synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, UMP biosynthetic process, pyrimidine nucleobase biosynthetic process, pyrimidine nucleotide biosynthetic process; MF: carboxy-lyase activity, catalytic activity, glycosyltransferase activity, identical protein binding, lyase activity, orotate phosphoribosyltransferase activity, orotidine-5'-phosphate decarboxylase activity, transferase activity; CC: cytoplasm, nucleus
Pathways: Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine biosynthesis, Pyrimidine metabolism - Mus musculus (mouse), pyrimidine ribonucleotides <i>de novo</i> biosynthesis, uridine-5,-phosphate biosynthesis
UniProt: P13439
Entrez ID: 22247
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Elp3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Elp3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Elp3 (elongator acetyltransferase complex subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: central nervous system development, nervous system development, neuron migration, positive regulation of cell migration, regulation of transcription by RNA polymerase II, tRNA processing, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, tRNA wobble uridine modification; MF: 4 iron, 4 sulfur cluster binding, RNA binding, acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, catalytic activity, iron-sulfur cluster binding, metal ion binding, phosphorylase kinase regulator activity, tRNA binding, tRNA uridine(34) acetyltransferase activity, transferase activity; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleolus, nucleus
Pathways:
UniProt: Q9CZX0
Entrez ID: 74195
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sepsecs
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sepsecs in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sepsecs (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: conversion of seryl-tRNAsec to selenocys-tRNAsec, selenocysteine incorporation, translation; MF: O-phosphoseryl-tRNA(Sec) selenium transferase activity, RNA binding, protein binding, tRNA binding, transferase activity; CC: cytoplasm, nucleus
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse)
UniProt: Q6P6M7
Entrez ID: 211006
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sin3a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sin3a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sin3a (transcriptional regulator, SIN3A (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, activation of innate immune response, cellular response to dopamine, cellular response to glucose stimulus, cellular response to tert-butyl hydroperoxide, cerebral cortex neuron differentiation, hematopoietic progenitor cell differentiation, heterochromatin formation, in utero embryonic development, intracellular protein localization, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of circadian rhythm, negative regulation of protein localization to nucleus, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of defense response to virus by host, positive regulation of neuron differentiation, positive regulation of stem cell population maintenance, regulation of DNA-templated transcription, regulation of axon extension, regulation of cell cycle, regulation of hormone levels, response to methylglyoxal, rhythmic process, type I interferon-mediated signaling pathway; MF: DNA binding, RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, protein binding, protein-containing complex binding, transcription corepressor activity, transcription regulator inhibitor activity; CC: Sin3-type complex, chromatin, chromosome, histone deacetylase complex, kinetochore, nucleolus, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex, transcription repressor complex
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Developmental Biology, Epstein-Barr virus infection - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of MECP2 expression and activity, Regulation of MITF-M-dependent genes involved in apoptosis, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of lipid metabolism by PPARalpha, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional Regulation by MECP2, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: Q60520
Entrez ID: 20466
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl13
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl13 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl13 (ribosomal protein L13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47963
Entrez ID: 270106
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Chd4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Chd4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Chd4 (chromodomain helicase DNA binding protein 4)
Type: protein-coding
Summary: Enables DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including double-strand break repair via homologous recombination; negative regulation of macromolecule biosynthetic process; and terminal button organization. Located in nucleus. Part of NuRD complex and protein-DNA complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; genitourinary system; and nervous system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in Sifrim-Hitz-Weiss syndrome; colorectal cancer (multiple); lung cancer (multiple); and lymphoma. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, oxygen transport, positive regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation, regulation of synapse assembly, terminal button organization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone binding, histone deacetylase binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, transcription coregulator binding, transcription corepressor activity, zinc ion binding; CC: NuRD complex, RNA polymerase II transcription regulator complex, centrosome, cerebellar granule cell to Purkinje cell synapse, chromatin, chromosome, telomeric region, cytoplasm, cytoskeleton, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, site of DNA damage
Pathways: Chromatin modifying enzymes, Chromatin organization, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Human papillomavirus infection - Mus musculus (mouse), Intracellular signaling by second messengers, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q6PDQ2
Entrez ID: 107932
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3d
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3d in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3d (eukaryotic translation initiation factor 3, subunit D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: IRES-dependent viral translational initiation, cap-dependent translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA cap binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: O70194
Entrez ID: 55944
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3g
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3g in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3g (eukaryotic translation initiation factor 3, subunit G)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, nucleic acid binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, nucleus, perinuclear region of cytoplasm
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9Z1D1
Entrez ID: 53356
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Exosc10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Exosc10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Exosc10 (exosome component 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, DNA damage response, DNA repair, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), histone mRNA catabolic process, maturation of 5.8S rRNA, negative regulation of telomere maintenance via telomerase, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent antisense transcript catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nucleobase-containing compound metabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of mRNA cis splicing, via spliceosome, rRNA processing, random inactivation of X chromosome, regulation of gene expression, regulation of nucleobase-containing compound metabolic process, regulation of telomerase RNA localization to Cajal body, ribosomal small subunit biogenesis; MF: 3'-5' exonuclease activity, 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, single-stranded RNA binding, telomerase RNA binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P56960
Entrez ID: 50912
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps27
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps27 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps27 (ribosomal protein S27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, metal ion binding, protein binding, structural constituent of ribosome, zinc ion binding; CC: GABA-ergic synapse, cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, glutamatergic synapse, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cap-dependent Translation Initiation, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Coronavirus disease - COVID-19 - Mus musculus (mouse), EML4 and NUDC in mitotic spindle formation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, M Phase, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWU9
Entrez ID: 57294
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3i
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3i in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3i (eukaryotic translation initiation factor 3, subunit I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: RNA binding, protein binding, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q9QZD9
Entrez ID: 54709
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Brd2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Brd2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Brd2 (bromodomain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, chromatin looping, chromatin organization, chromatin remodeling, neural tube closure, nucleosome assembly, positive regulation of T-helper 17 cell lineage commitment, protein localization to chromatin, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: acetylation-dependent protein binding, histone H3K14ac reader activity, histone H4K12ac reader activity, histone H4K5ac reader activity, histone reader activity, protein serine/threonine kinase activity; CC: chromatin, chromosome, cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q7JJ13
Entrez ID: 14312
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps5 (ribosomal protein S5)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in regulation of translational fidelity; ribosomal small subunit assembly; and translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including brain; embryo ectoderm; genitourinary system; gut; and sensory organ. Orthologous to human RPS5 (ribosomal protein S5). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoplasmic translation, regulation of translational fidelity, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97461
Entrez ID: 20103
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dph3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dph3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dph3 (diphthamine biosynthesis 3)
Type: protein-coding
Summary: Predicted to enable electron transfer activity; ferrous iron binding activity; and iron chaperone activity. Involved in protein histidyl modification to diphthamide. Part of protein-containing complex. Is active in cytosol. Orthologous to several human genes including DPH3 (diphthamide biosynthesis 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of protein secretion, positive regulation of binding, protein histidyl modification to diphthamide, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation; MF: electron transfer activity, ferrous iron binding, iron chaperone activity, metal ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q8K0W9
Entrez ID: 105638
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl4
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl4 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl4 (ribosomal protein L4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: 5S rRNA binding, RNA binding, protein binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, large ribosomal subunit, nuclear body, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D8E6
Entrez ID: 67891
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Elp5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Elp5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Elp5 (elongator acetyltransferase complex subunit 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cell migration, tRNA modification, tRNA processing, tRNA wobble uridine modification; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus
Pathways:
UniProt: Q99L85
Entrez ID: 54351
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif1ad
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif1ad in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif1ad (eukaryotic translation initiation factor 1A domain containing)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: RNA binding, translation initiation factor activity; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q3THJ3
Entrez ID: 69860
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
N6amt1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of N6amt1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arsonoacetate metabolic process, chromatin organization, methylation, negative regulation of gene expression, epigenetic, peptidyl-glutamine methylation, positive regulation of cell growth, toxin metabolic process, transcription initiation-coupled chromatin remodeling; MF: S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, arsenite methyltransferase activity, histone H4K12 methyltransferase activity, histone methyltransferase activity, methyltransferase activity, nucleic acid binding, protein binding, protein methyltransferase activity, protein-glutamine N-methyltransferase activity, site-specific DNA-methyltransferase (adenine-specific) activity, transferase activity; CC: eRF1 methyltransferase complex, nucleus, protein-containing complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q6SKR2
Entrez ID: 67768
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pelo
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pelo in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pelo (pelota mRNA surveillance and ribosome rescue factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA surveillance, cell division, chromosome organization, endoderm development, inner cell mass cell proliferation, mesenchymal to epithelial transition, nonfunctional rRNA decay, nuclear-transcribed mRNA catabolic process, no-go decay, nuclear-transcribed mRNA catabolic process, non-stop decay, positive regulation of BMP signaling pathway, regulation of translation, rescue of stalled ribosome, ribosome disassembly, stem cell population maintenance; MF: metal ion binding, nucleoside-triphosphatase regulator activity, protein binding, ribosome binding, stalled ribosome sensor activity; CC: Dom34-Hbs1 complex, cytoplasm, cytosolic ribosome
Pathways: Metabolism of proteins, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q80X73
Entrez ID: 105083
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nmnat1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nmnat1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nmnat1 (nicotinamide nucleotide adenylyltransferase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP generation from poly-ADP-D-ribose, NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, negative regulation of DNA-templated transcription, negative regulation of adipose tissue development, negative regulation of apoptotic DNA fragmentation, negative regulation of neuron apoptotic process, nicotinamide metabolic process, nucleotide biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of adipose tissue development, purine nucleotide metabolic process, pyridine nucleotide biosynthetic process, response to wounding; MF: ATP binding, catalytic activity, identical protein binding, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, protein ADP-ribosyltransferase-substrate adaptor activity, transferase activity; CC: chromatin, cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD biosynthesis II (from tryptophan), NAD biosynthesis III, NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD salvage pathway II, NAD salvage pathway III, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism, pyridine nucleotide cycling
UniProt: Q9EPA7
Entrez ID: 66454
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dis3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dis3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dis3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CUT catabolic process, RNA catabolic process, RNA processing, nuclear mRNA surveillance of mRNA 3'-end processing, nuclear-transcribed mRNA catabolic process, rRNA catabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA nuclease activity, endonuclease activity, exonuclease activity, guanyl-nucleotide exchange factor activity, hydrolase activity, nuclease activity; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exosome (RNase complex), nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Mus musculus (mouse), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CSH3
Entrez ID: 72662
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ypel5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ypel5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ypel5 (yippee like 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, cell population proliferation; MF: metal ion binding, molecular_function; CC: centrosome, cytoplasm, cytoskeleton, midbody, mitotic spindle pole, nucleus, spindle pole, ubiquitin ligase complex
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P62700
Entrez ID: 383295
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps13
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps13 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps13 (ribosomal protein S13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, ribosomal small subunit biogenesis, translation; MF: 5.8S rRNA binding, mRNA 5'-UTR binding, mRNA binding, small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62301
Entrez ID: 68052
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3c
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3c in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3c (eukaryotic translation initiation factor 3, subunit C)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: RNA binding, ribosome binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q8R1B4
Entrez ID: 56347
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps6 (ribosomal protein S6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, T cell differentiation in thymus, T cell proliferation involved in immune response, TOR signaling, activation-induced cell death of T cells, cellular response to ethanol, cytoplasmic translation, erythrocyte development, gastrulation, glucose homeostasis, mammalian oogenesis stage, mitotic cell cycle, negative regulation of apoptotic process, negative regulation of bicellular tight junction assembly, placenta development, positive regulation of apoptotic process, positive regulation of cell population proliferation, rRNA processing, response to insulin, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis, translation; MF: mRNA binding, protein binding, protein kinase binding, structural constituent of ribosome; CC: GABA-ergic synapse, cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, dendrite, endoplasmic reticulum, nucleolus, nucleus, perinuclear region of cytoplasm, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Apelin signaling pathway - Mus musculus (mouse), Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, HIF-1 signaling pathway - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, MTOR signalling, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PI3K-Akt signaling pathway - Mus musculus (mouse), Post-translational protein modification, Protein hydroxylation, Proteoglycans in cancer - Mus musculus (mouse), Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Signal Transduction, Thermogenesis - Mus musculus (mouse), Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, mTOR signaling pathway - Mus musculus (mouse), mTORC1-mediated signalling, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62754
Entrez ID: 20104
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl36a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl36a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl36a (ribosomal protein L36A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, plasma membrane, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P83882
Entrez ID: 19982
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps16
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps16 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps16 (ribosomal protein S16)
Type: protein-coding
Summary: A structural constituent of ribosome. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in early conceptus and secondary oocyte. Orthologous to human RPS16 (ribosomal protein S16). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cellular response to leukemia inhibitory factor, cytoplasmic translation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14131
Entrez ID: 20055
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fau
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fau in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fau (FAU ubiquitin like and ribosomal protein S30 fusion)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-positive bacterium, innate immune response in mucosa, modification-dependent protein catabolic process, protein ubiquitination, ribosomal small subunit assembly, translation; MF: protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular space, nucleus, ribonucleoprotein complex, ribosome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62862
Entrez ID: 14109
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eefsec
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eefsec in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eefsec (eukaryotic elongation factor, selenocysteine-tRNA-specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: selenocysteine incorporation, translation; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding, ribonucleoprotein complex binding, selenocysteine insertion sequence binding, tRNA binding, translation elongation factor activity; CC: cytoplasm, cytosol, mitochondrion, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q9JHW4
Entrez ID: 65967
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pwp1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pwp1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pwp1 (PWP1 homolog, endonuclein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, negative regulation of DNA-templated transcription, positive regulation of stem cell differentiation, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, rRNA processing, regulation of DNA-templated transcription, ribosome biogenesis; MF: histone H4K20me3 reader activity; CC: Golgi apparatus, chromosome, nucleolus, nucleus
Pathways:
UniProt: Q99LL5
Entrez ID: 103136
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Wdr74
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Wdr74 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Wdr74 (WD repeat domain 74)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA metabolic process, blastocyst formation, rRNA processing, ribosomal large subunit biogenesis; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q8VCG3
Entrez ID: 107071
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps7
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps7 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps7 (ribosomal protein S7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, negative regulation of ubiquitin-dependent protein catabolic process, neural crest cell differentiation, neural tube closure, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, protein stabilization, rRNA processing, ribosomal small subunit biogenesis, translation; MF: mRNA 3'-UTR binding, mRNA 5'-UTR binding, poly(U) RNA binding, protein kinase binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, protein-containing complex, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62082
Entrez ID: 20115
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polr2b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polr2b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polr2b (polymerase (RNA) II (DNA directed) polypeptide B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, RNA-templated transcription, transcription by RNA polymerase II; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, RNA-directed RNA polymerase activity, chromatin binding, hydrolase activity, metal ion binding, nucleotidyltransferase activity, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase II, core complex, chromosome, telomeric region, nucleoplasm, nucleus
Pathways: DNA Repair, Dual incision in TC-NER, ESR-mediated signaling, Estrogen-dependent gene expression, FGFR2 alternative splicing, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Mus musculus (mouse), Metabolism of RNA, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase - Mus musculus (mouse), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q8CFI7
Entrez ID: 231329
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Slc25a26
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Slc25a26 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Slc25a26 (solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26)
Type: protein-coding
Summary: Predicted to enable S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity. Predicted to be involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, S-adenosyl-L-methionine transport, mitochondrial S-adenosyl-L-methionine transmembrane transport, purine nucleoside transmembrane transport, transmembrane transport; MF: S-adenosyl-L-methionine transmembrane transporter activity, S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity, antiporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q5U680
Entrez ID: 67582
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Elp2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Elp2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Elp2 (elongator acetyltransferase complex subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome assembly, regulation of receptor signaling pathway via JAK-STAT, tRNA processing, tRNA wobble uridine modification, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, endopeptidase activator activity, protein binding, protein kinase binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus, proteasome complex, transcription elongation factor complex
Pathways:
UniProt: Q91WG4
Entrez ID: 58523
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps29
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps29 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps29 (ribosomal protein S29)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to act upstream of or within translation. Part of cytosolic small ribosomal subunit. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 13. Orthologous to human RPS29 (ribosomal protein S29). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, translation; MF: metal ion binding, structural constituent of ribosome, zinc ion binding; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62274
Entrez ID: 20090
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rplp2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rplp2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rplp2 (ribosomal protein lateral stalk subunit P2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, cytoplasmic translational elongation, translation at postsynapse, translation at presynapse, translational elongation; MF: iron ion binding, ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P99027
Entrez ID: 67186
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fam204a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fam204a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fam204a (family with sequence similarity 204, member A)
Type: protein-coding
Summary: Orthologous to human FAM204A (family with sequence similarity 204 member A). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q8C6C7
Entrez ID: 76539
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pdap1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pdap1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pdap1 (PDGFA associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytosol, extracellular space, plasma membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q3UHX2
Entrez ID: 231887
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl15
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl15 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl15 (ribosomal protein L15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: A band, cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosomal subunit, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CZM2
Entrez ID: 66480
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Dhfr
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Dhfr in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Dhfr (dihydrofolate reductase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon regeneration, dTMP biosynthetic process, dihydrofolate metabolic process, folic acid metabolic process, one-carbon metabolic process, regulation of removal of superoxide radicals, response to methotrexate, tetrahydrobiopterin biosynthetic process, tetrahydrofolate biosynthetic process, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: NADP binding, NADPH binding, RNA binding, dihydrofolate reductase activity, dihydrofolic acid binding, folate reductase activity, folic acid binding, mRNA binding, mRNA regulatory element binding translation repressor activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor, sequence-specific mRNA binding; CC: cytoplasm, cytosol, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleus
Pathways: Folate biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, One carbon pool by folate - Mus musculus (mouse), folate transformations II (plants)
UniProt: P00375
Entrez ID: 13361
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Xpo1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Xpo1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Xpo1 (exportin 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to salt, cellular response to triglyceride, intracellular protein transport, mRNA export from nucleus, mRNA transport, negative regulation of transcription by RNA polymerase II, nucleocytoplasmic transport, protein export from nucleus, protein localization to nucleus, protein transport, regulation of centrosome duplication, regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of protein catabolic process, regulation of protein export from nucleus, response to xenobiotic stimulus, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, ribosome biogenesis; MF: DNA-binding transcription factor binding, RNA binding, nuclear export signal receptor activity, protein binding, protein domain specific binding, small GTPase binding; CC: Cajal body, annulate lamellae, cytoplasm, cytosol, kinetochore, nuclear membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Cyclin A/B1/B2 associated events during G2/M transition, Deactivation of the beta-catenin transactivating complex, Developmental Biology, EML4 and NUDC in mitotic spindle formation, ESR-mediated signaling, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, G2/M Transition, Heme signaling, HuR (ELAVL1) binds and stabilizes mRNA, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), M Phase, MAPK family signaling cascades, MAPK6/MAPK4 signaling, MITF-M-regulated melanocyte development, Metabolism of RNA, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleocytoplasmic transport - Mus musculus (mouse), RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of mRNA stability by proteins that bind AU-rich elements, Resolution of Sister Chromatid Cohesion, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: Q6P5F9
Entrez ID: 103573
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl26
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl26 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl26 (ribosomal protein L26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, cellular response to ionizing radiation, cytoplasmic translation, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, ribosomal large subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA 5'-UTR binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, nucleolus, nucleoplasm, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse, terminal bouton
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61255
Entrez ID: 19941
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polg2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polg2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polg2 (polymerase (DNA directed), gamma 2, accessory subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA repair, DNA replication, DNA-templated DNA replication, in utero embryonic development, mitochondrial DNA metabolic process, mitochondrial DNA replication, mitochondrion organization; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, DNA-directed DNA polymerase activity, double-stranded DNA binding, identical protein binding; CC: cytoplasm, gamma DNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: DNA Replication, Strand-asynchronous mitochondrial DNA replication
UniProt: Q9QZM2
Entrez ID: 50776
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps4x
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps4x in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps4x (ribosomal protein S4, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell population proliferation, positive regulation of translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62702
Entrez ID: 20102
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polr1b
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polr1b in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polr1b (polymerase (RNA) I polypeptide B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, embryo implantation, neural crest formation, nucleologenesis, rRNA transcription; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromosome, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Mus musculus (mouse)
UniProt: P70700
Entrez ID: 20017
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ctu2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ctu2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ctu2 (cytosolic thiouridylase subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: nucleotidyltransferase activity, sulfurtransferase activity, tRNA binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q3U308
Entrez ID: 66965
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl18
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl18 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl18 (ribosomal protein L18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, nucleolus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P35980
Entrez ID: 19899
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pcna
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pcna in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pcna (proliferating cell nuclear antigen)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenobiotic stimulus, chromatin organization, epithelial cell differentiation, estrous cycle, heart development, leading strand elongation, liver regeneration, mismatch repair, mitotic telomere maintenance via semi-conservative replication, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of deoxyribonuclease activity, regulation of DNA replication, replication fork processing, response to L-glutamate, response to cadmium ion, response to dexamethasone, response to estradiol, response to lipid, response to oxidative stress, translesion synthesis; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, enzyme binding, histone acetyltransferase binding, identical protein binding, nuclear estrogen receptor binding, protein binding, protein-containing complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, receptor tyrosine kinase binding; CC: PCNA complex, PCNA-p21 complex, centrosome, chromatin, cyclin-dependent protein kinase holoenzyme complex, male germ cell nucleus, nuclear body, nuclear lamina, nuclear replication fork, nucleoplasm, nucleus, replication fork
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Mus musculus (mouse), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism of proteins, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Post-translational protein modification, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Protein ubiquitination, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Tight junction - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P17918
Entrez ID: 18538
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Emg1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Emg1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Emg1 (EMG1 N1-specific pseudouridine methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst development, methylation, nucleologenesis, rRNA base methylation, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, identical protein binding, methyltransferase activity, rRNA (pseudouridine) methyltransferase activity, rRNA binding, transferase activity; CC: chromosome, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O35130
Entrez ID: 14791
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sap130
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sap130 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sap130 (Sin3A associated protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: embryonic placenta development, in utero embryonic development, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of stem cell population maintenance, regulation of DNA-templated transcription; CC: Sin3-type complex, nuclear speck, nucleus
Pathways:
UniProt: Q8BIH0
Entrez ID: 269003
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ddx21
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ddx21 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ddx21 (DExD box helicase 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: R-loop processing, chromatin remodeling, defense response to virus, immune system process, innate immune response, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid dendritic cell cytokine production, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, rRNA processing, regulation of gene expression, response to exogenous dsRNA, response to virus, transcription by RNA polymerase II; MF: 7SK snRNA binding, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, miRNA binding, nucleic acid binding, nucleotide binding, protein binding, rRNA binding, snoRNA binding; CC: B-WICH complex, chromosome, cytoplasm, cytosol, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Positive epigenetic regulation of rRNA expression, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9JIK5
Entrez ID: 56200
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Sbds
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Sbds in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Sbds (SBDS ribosome maturation factor)
Type: protein-coding
Summary: This gene encodes a protein that is necessary for ribosome function and maintaining normal levels of protein synthesis. The encoded protein may function to activate ribosomes for translation, and may be involved in cellular response to stress and DNA damage. Loss of this gene is embryonic lethal while deficiency of the encoded protein in the pancreas is associated with symptoms of Shwachman-Diamond syndrome. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: bone marrow development, bone mineralization, cytosolic ribosome assembly, hematopoietic progenitor cell differentiation, inner cell mass cell proliferation, leukocyte chemotaxis, mitotic spindle organization, rRNA processing, ribosome biogenesis; MF: microtubule binding, rRNA binding, ribosome binding; CC: cytoplasm, cytoskeleton, cytosol, nucleolus, nucleoplasm, nucleus, spindle, spindle pole
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: P70122
Entrez ID: 66711
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps15a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps15a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps15a (ribosomal protein S15A)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in several processes, including positive regulation of cell population proliferation; response to virus; and ribosomal small subunit biogenesis. Located in mitochondrion. Part of cytosolic small ribosomal subunit. Is active in synapse. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell cycle, positive regulation of cell population proliferation, response to virus, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, mitochondrion, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62245
Entrez ID: 267019
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Fxn
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Fxn in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Fxn (frataxin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, adult walking behavior, aerobic respiration, cellular response to hydrogen peroxide, embryo development ending in birth or egg hatching, heme biosynthetic process, inorganic ion homeostasis, intracellular iron ion homeostasis, intracellular monoatomic cation homeostasis, iron import into the mitochondrion, iron ion transport, iron-sulfur cluster assembly, mitochondrion organization, monoatomic ion transport, muscle cell cellular homeostasis, negative regulation of apoptotic process, negative regulation of lipid storage, negative regulation of multicellular organism growth, negative regulation of neuron apoptotic process, negative regulation of organ growth, negative regulation of release of cytochrome c from mitochondria, oxidative phosphorylation, positive regulation of axon extension, positive regulation of mitochondrial membrane permeability, proprioception, protein autoprocessing, protein maturation, regulation of cytosolic calcium ion concentration, regulation of growth, response to iron ion; MF: 2 iron, 2 sulfur cluster binding, enzyme activator activity, enzyme binding, ferric iron binding, ferrous iron binding, ferroxidase activity, iron chaperone activity, metal ion binding, oxidoreductase activity; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Protein localization, Respiratory electron transport
UniProt: O35943
Entrez ID: 14297
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ppcs
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ppcs in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ppcs (phosphopantothenoylcysteine synthetase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA biosynthetic process, coenzyme A biosynthetic process, heart process; MF: ATP binding, identical protein binding, ligase activity, nucleotide binding, phosphopantothenate--cysteine ligase activity, protein homodimerization activity; CC: cytoplasm, nucleus
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q8VDG5
Entrez ID: 106564
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Pak1ip1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Pak1ip1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Pak1ip1 (PAK1 interacting protein 1)
Type: protein-coding
Summary: Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cell population proliferation and roof of mouth development. Located in nucleolus. Is expressed in several structures, including brain; chondrocranium; face; heart; and liver. Orthologous to human PAK1IP1 (PAK1 interacting protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell population proliferation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of signal transduction, regulation of signal transduction by p53 class mediator, ribosomal large subunit biogenesis, ribosome biogenesis, roof of mouth development; MF: protein binding, protein kinase inhibitor activity; CC: nucleolus, nucleus
Pathways:
UniProt: Q9DCE5
Entrez ID: 68083
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mrpl41
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mrpl41 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mrpl41 (mitochondrial ribosomal protein L41)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, mitochondrial translation, translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CQN7
Entrez ID: 107733
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl6 (ribosomal protein L6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: 5.8S rRNA binding, RNA binding, mRNA binding, structural constituent of ribosome, tRNA binding; CC: A band, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, large ribosomal subunit, nucleolus, nucleus, postsynapse, postsynaptic density, presynapse, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P47911
Entrez ID: 19988
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps11 (ribosomal protein S11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62281
Entrez ID: 27207
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Anapc11
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Anapc11 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Anapc11 (anaphase promoting complex subunit 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell division, positive regulation of mitotic metaphase/anaphase transition, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: G protein-coupled receptor binding, cullin family protein binding, metal ion binding, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: anaphase-promoting complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9CPX9
Entrez ID: 66156
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl35
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl35 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl35 (ribosomal protein L35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation, translation at postsynapse, translation at presynapse; MF: mRNA binding, protein binding, ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWV7
Entrez ID: 66489
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Prdm10
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Prdm10 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Prdm10 (PR domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, zinc ion binding; CC: chromatin, nucleus, transcription repressor complex
Pathways:
UniProt:
Entrez ID: 382066
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Mtg2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Mtg2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Mtg2 (mitochondrial ribosome associated GTPase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, regulation of mitochondrial translation, regulation of respiratory system process, ribosome biogenesis; MF: GTP binding, GTPase activity, magnesium ion binding, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion
Pathways:
UniProt: I6L986, A2AFK4
Entrez ID: 52856
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif2s1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif2s1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif2s1 (eukaryotic translation initiation factor 2, subunit 1 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: HRI-mediated signaling, PERK-mediated unfolded protein response, cellular response to UV, cellular response to amino acid starvation, cellular response to chemical stress, cellular response to heat, cellular response to oxidative stress, mitochondrial respirasome assembly, mitophagy, negative regulation of translational initiation in response to stress, positive regulation of type B pancreatic cell apoptotic process, regulation of translation, regulation of translation in response to endoplasmic reticulum stress, regulation of translational initiation in response to stress, response to endoplasmic reticulum stress, response to kainic acid, response to manganese-induced endoplasmic reticulum stress, stress granule assembly, translation, translational initiation; MF: RNA binding, nucleic acid binding, protein binding, ribosome binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 2 complex, glial limiting end-foot, mitochondrion, nucleus, synapse, translation initiation ternary complex
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Influenza A - Mus musculus (mouse), L13a-mediated translational silencing of Ceruloplasmin expression, Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Metabolism of proteins, Non-alcoholic fatty liver disease - Mus musculus (mouse), PERK regulates gene expression, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Recycling of eIF2:GDP, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR)
UniProt: Q6ZWX6
Entrez ID: 13665
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Keap1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Keap1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Keap1 (kelch-like ECH-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to carbohydrate stimulus, cellular response to interleukin-4, cellular response to oxidative stress, in utero embryonic development, negative regulation of gene expression, negative regulation of response to oxidative stress, negative regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein ubiquitination, regulation of DNA-templated transcription, regulation of autophagy, regulation of epidermal cell differentiation, response to oxidative stress, ubiquitin-dependent protein catabolic process; MF: RNA polymerase II-specific DNA-binding transcription factor binding, disordered domain specific binding, identical protein binding, protein binding, transcription regulator inhibitor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, actin filament, adherens junction, centriolar satellite, cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, inclusion body, midbody, nucleoplasm, nucleus, protein-containing complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Class I MHC mediated antigen processing & presentation, Deubiquitination, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Immune System, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q9Z2X8
Entrez ID: 50868
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ctdnep1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ctdnep1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ctdnep1 (CTD nuclear envelope phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gamete generation, mesoderm development, nuclear envelope organization, positive regulation of canonical Wnt signaling pathway, positive regulation of triglyceride biosynthetic process, protein localization to nucleus; MF: hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: Nem1-Spo7 phosphatase complex, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, lipid droplet, membrane, nuclear envelope, nuclear membrane, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Depolymerization of the Nuclear Lamina, M Phase, Mitotic Prophase, Nuclear Envelope Breakdown
UniProt: Q3TP92
Entrez ID: 67181
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rrp9
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rrp9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rrp9 (ribosomal RNA processing 9, U3 small nucleolar RNA binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis; MF: RNA binding, U3 snoRNA binding, snoRNA binding; CC: box C/D methylation guide snoRNP complex, nucleolus, nucleus, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q91WM3
Entrez ID: 27966
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tmx2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tmx2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tmx2 (thioredoxin-related transmembrane protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: brain development; MF: disulfide oxidoreductase activity, identical protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q9D710
Entrez ID: 66958
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tyms
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tyms in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tyms (thymidylate synthase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate as a cofactor. This function maintains the thymidine-5-prime monophosphate concentration critical for DNA replication and repair. The encoded enzyme is a target for cancer chemotherapeutic agents. The majority of transcripts for this gene lack a 3' UTR (PMID: 3022294, 3444407). The stop codon in these transcripts is UAA, compared to the UAG found in the genome and longer transcripts, as the polyA site is located within the stop codon (PMID: 3444407, 2157203). A related pseudogene has been identified on chromosome 10. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: dTMP biosynthetic process, dTTP biosynthetic process, methylation, negative regulation of translation, nucleotide biosynthetic process, regulation of translation, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: folic acid binding, heterocyclic compound binding, mRNA binding, mRNA regulatory element binding translation repressor activity, methyltransferase activity, protein homodimerization activity, sequence-specific mRNA binding, thymidylate synthase activity, transferase activity, transferase activity, transferring one-carbon groups; CC: cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, One carbon pool by folate - Mus musculus (mouse), Pyrimidine metabolism - Mus musculus (mouse), folate transformations II (plants), purine and pyrimidine metabolism, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis I
UniProt: P07607
Entrez ID: 22171
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Coa5
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Coa5 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Coa5 (cytochrome C oxidase assembly factor 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: leukocyte differentiation, mitochondrial cytochrome c oxidase assembly, multicellular organism growth, spleen development, thymus development; CC: mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport, Thermogenesis - Mus musculus (mouse)
UniProt: Q99M07
Entrez ID: 76178
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps9
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps9 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps9 (ribosomal protein S9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation; MF: 5.8S rRNA binding, RNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWN5
Entrez ID: 76846
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl19
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl19 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl19 (ribosomal protein L19)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to act upstream of or within translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in cumulus oophorus; early conceptus; oocyte; and ovary. Orthologous to human RPL19 (ribosomal protein L19). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, translation; MF: 5.8S rRNA binding, RNA binding, large ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleolus, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P84099
Entrez ID: 19921
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Suds3
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Suds3 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Suds3 (suppressor of defective silencing 3 homolog (S. cerevisiae))
Type: protein-coding
Summary: Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, blastocyst hatching, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of stem cell population maintenance, regulation of gene expression; MF: enzyme binding, histone deacetylase activity, histone deacetylase binding, identical protein binding, protein binding; CC: Sin3-type complex, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, HDACs deacetylate histones, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8BR65
Entrez ID: 71954
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Nmnat2
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Nmnat2 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Nmnat2 (nicotinamide nucleotide adenylyltransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, NADP+ biosynthetic process, cytoplasmic translation, negative regulation of cytoplasmic translation, nicotinamide metabolic process, nicotinamide riboside metabolic process, pyridine nucleotide biosynthetic process; MF: ATP binding, catalytic activity, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, protein ADP-ribosyltransferase-substrate adaptor activity, transferase activity; CC: Golgi apparatus, Golgi membrane, axon, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, extrinsic component of membrane, late endosome, membrane, synapse, trans-Golgi network, transport vesicle
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD biosynthesis II (from tryptophan), NAD biosynthesis III, NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD salvage pathway II, NAD salvage pathway III, Nicotinate and nicotinamide metabolism - Mus musculus (mouse), Nicotinate metabolism, pyridine nucleotide cycling
UniProt: Q8BNJ3
Entrez ID: 226518
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Ctu1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Ctu1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Ctu1 (cytosolic thiouridylase subunit 1)
Type: protein-coding
Summary: Predicted to enable tRNA binding activity. Predicted to be involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Is expressed in brain. Orthologous to human CTU1 (cytosolic thiouridylase subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: RNA binding, nucleotidyltransferase activity, tRNA binding, transferase activity; CC: cytoplasm, cytosol, cytosolic tRNA wobble base thiouridylase complex, mitochondrion
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q99J10
Entrez ID: 233189
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Polr1e
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Polr1e in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Polr1e (polymerase (RNA) I polypeptide E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I general transcription initiation factor binding, protein binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Mus musculus (mouse)
UniProt: Q8K202
Entrez ID: 64424
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl34
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl34 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl34 (ribosomal protein L34)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; translation at postsynapse; and translation at presynapse. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human RPL34 (ribosomal protein L34). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cytoplasmic translation, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, mitochondrion, nucleolus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9D1R9
Entrez ID: 68436
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rpl18a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rpl18a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rpl18a (ribosomal protein L18A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, translation; MF: structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome - Mus musculus (mouse), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62717
Entrez ID: 76808
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Atad3a
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Atad3a in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Atad3a (ATPase family, AAA domain containing 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, HRI-mediated signaling, PERK-mediated unfolded protein response, antiviral innate immune response, mitochondrion organization, negative regulation of PERK-mediated unfolded protein response, negative regulation of apoptotic process, regulation of cell growth, translational initiation; MF: ATP binding, ATP hydrolysis activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein serine/threonine kinase inhibitor activity; CC: membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrion
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q925I1
Entrez ID: 108888
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Grpel1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Grpel1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Grpel1 (GrpE-like 1, mitochondrial)
Type: protein-coding
Summary: Predicted to enable several functions, including ATPase binding activity; adenyl-nucleotide exchange factor activity; and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; bone; midbrain ventricular layer; and submandibular gland primordium. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: protein folding, protein import into mitochondrial matrix; MF: ATPase activator activity, ATPase binding, adenyl-nucleotide exchange factor activity, identical protein binding, protein homodimerization activity, protein-folding chaperone binding, unfolded protein binding; CC: PAM complex, Tim23 associated import motor, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways:
UniProt: Q99LP6
Entrez ID: 17713
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Tut1
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Tut1 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Tut1 (terminal uridylyl transferase 1, U6 snRNA-specific)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, RNA metabolic process, U6 snRNA 3'-end processing, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, histone mRNA catabolic process, mRNA 3'-end processing, mRNA processing, regulation of RNA metabolic process, snRNA processing; MF: ATP binding, RNA binding, RNA uridylyltransferase activity, U6 snRNA binding, enzyme binding, enzyme-substrate adaptor activity, mRNA 3'-UTR binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, poly(A) RNA polymerase activity, transferase activity, zinc ion binding; CC: cytosol, mRNA cleavage and polyadenylation specificity factor complex, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8R3F9
Entrez ID: 70044
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Eif3h
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Eif3h in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Eif3h (eukaryotic translation initiation factor 3, subunit H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, translation, translational initiation; MF: metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, translation initiation factor activity; CC: cytoplasm, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Measles - Mus musculus (mouse), Metabolism of proteins, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation
UniProt: Q91WK2
Entrez ID: 68135
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Rps24
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Rps24 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Rps24 (ribosomal protein S24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, erythrocyte homeostasis, rRNA processing, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: structural constituent of ribosome, translation initiation factor binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62849
Entrez ID: 20088
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cycs
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cycs in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cycs (cytochrome c, somatic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, hydrogen peroxide metabolic process, intrinsic apoptotic signaling pathway, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial electron transport, ubiquinol to cytochrome c; MF: electron transfer activity, enzyme binding, heme binding, metal ion binding; CC: apoptosome, cytosol, mitochondrial intermembrane space, mitochondrion, myelin sheath, nucleus
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Measles - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Viral myocarditis - Mus musculus (mouse), p53 signaling pathway - Mus musculus (mouse)
UniProt: P62897
Entrez ID: 13063
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Elp6
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Elp6 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Elp6 (elongator acetyltransferase complex subunit 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, autophagosome maturation, autophagy, cellular response to stress, homeostasis of number of retina cells, inflammasome-mediated signaling pathway, locomotory behavior, motor behavior, neuromuscular process, neuromuscular process controlling balance, neuron apoptotic process, photoreceptor cell differentiation, positive regulation of cell migration, protein folding, response to unfolded protein, retina development in camera-type eye, tRNA processing, tRNA wobble uridine modification, translation, ubiquitin recycling; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleus
Pathways:
UniProt: Q8BK75
Entrez ID: 72341
|
SCREEN_18_HITS_ONLY.tsv
|
mouse
|
knockout
|
Cdc23
|
NG2-3112 mouse glioblastoma cells
|
increased sensitivity to gliocidin and subsequently glioblastoma cell death
| 0
|
difficult
|
Does knockout of Cdc23 in NG2-3112 mouse glioblastoma cells causally result in increased sensitivity to gliocidin and subsequently glioblastoma cell death?
|
Gene: Cdc23 (CDC23 cell division cycle 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, mitotic cell cycle, mitotic metaphase chromosome alignment, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of mitotic metaphase/anaphase transition; CC: anaphase-promoting complex
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8BGZ4
Entrez ID: 52563
|
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