E3C 3.0 (RE / NER)
Collection
This collection includes relation exteration and name entity recognition datasets in English, Italian, Slovak, Slovenian, Polish and Greek.
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12 items
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Updated
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100310
| 1 |
We present a case of a 32-year-old woman with a history of gradual enlargement of the anterior neck.
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[] |
100310
| 2 |
The medical history was unremarkable and no comorbidities existed.
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[] |
100310
| 3 |
There was no history of radiation exposure.
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[] |
100310
| 4 |
Clinical examination revealed a multinodular goiter.
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[] |
100310
| 5 |
Computed tomography showed a thyroid nodule of the left lobe extended to the isthmus and the right lobe with anterior and posterior capsular rupture contracting close contact with the vascular axis left carotid-jugular plunging into the cervicothoracic away from the hole aortic arch.
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[] |
100310
| 6 |
There was no evidence of lung lesions.
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[] |
100310
| 7 |
The patient underwent a surgical exploration.
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[] |
100310
| 8 |
There was a hard left lobe nodule of 5 cm infiltrating the adjacent muscles and partially infiltrates the trachea.
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[] |
100310
| 9 |
The intraoperative consultation pathology diagnosis was: undifferentiated carcinoma.
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[] |
100310
| 10 |
A total thyroidectomy was realized.
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[] |
100310
| 11 |
Histological examination showed a proliferation of elongated spindle-shaped cells, arranged in interweaving fascicles of varying sizes, intersected at right angles.
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[] |
100310
| 12 |
Tumor cells are atypical with strange nuclei.
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[] |
100310
| 13 |
Chromatin is distributed inhomogeneously.
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[] |
100310
| 14 |
The cytoplasmic membrane is irregular and thick.
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[] |
100310
| 15 |
The nucleolus is very large.
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[] |
100310
| 16 |
The tumor realize a pushing against thyroid parenchyma which is separated with a fibrous capsule.
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[] |
100310
| 17 |
The mitotic rate was extremely high (19 mitosis/10 high power field), and atypical mitotic figures were also present.
|
[
[
"high",
"rate"
],
[
"19 mitosis/10 high power field",
"rate"
]
] |
100310
| 18 |
The neoplasia showed invasion of the peri-glandular fat tissue.
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[] |
100310
| 19 |
Immuno-histochemical staining of the slides with caldesmon, desmin, PanCK, CK5-6, CK7, myogenin, epithelial membrane antigen (EMA), CEA, thyroid transcription factor (TTF-1), pancytokeratin, smooth muscle actin (SMA), MelanA, S 100 protein, CD 45, CD3, CD30, CD 20, CD 15, CD34, ALK, calcitonin and KI 67 protein was performed.
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[] |
100310
| 20 |
The tumour was strongly positive for caldesmon, SMA, desmin, and negative for pancytokeratin and other epithelial, lymphoid and melanocytic markers.
|
[
[
"negative",
"markers"
],
[
"negative",
"pancytokeratin"
]
] |
100310
| 21 |
On the basis of the clinical, radiographic, histopathological and immunohistochemical features, the final diagnosis was primary thyroid leiomyosarcoma, FNCLCC grade 3.
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[] |
100310
| 22 |
In multidisciplinary tumour board, it was decided that adjuvant loco regional RT and chemotherapy by ifosfamide and doxorubicin.
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[] |
100339
| 1 |
A 21-year-old male was referred to the gastroenterology clinic for incidental findings of severe chronic pancreatitis on cross-sectional imaging but no associated symptoms of pancreatitis.
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[] |
100339
| 2 |
He had presented to the emergency department for abdominal pain consistent with prior episodes of renal colic.
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[] |
100339
| 3 |
Computed tomography scan confirmed the presence of renal calculi that passed with conservative management.
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[] |
100339
| 4 |
An incidental finding on the imaging showed marked pancreatic atrophy with multiple sub-centimeter calcifications consistent with severe chronic pancreatitis.
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[] |
100339
| 5 |
Remarkably, he did not report having any symptoms associated with pancreatic insufficiency including epigastric pain, vomiting, steatorrhea and weight loss.
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[] |
100339
| 6 |
He denied having any prior episodes of acute pancreatitis and had no history of alcohol use.
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[] |
100339
| 7 |
His laboratory tests were all within normal range, including complete blood count, liver function tests, amylase and lipase.
|
[
[
"normal range",
"tests"
],
[
"normal range",
"tests"
],
[
"normal range",
"count"
],
[
"normal range",
"lipase"
],
[
"normal range",
"amylase"
]
] |
100339
| 8 |
His family history was significant as his father had an isolated episode of pancreatitis which required abdominal surgery.
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[] |
100339
| 9 |
Magnetic resonance cholangiopancreatography (MRCP) showed severe parenchymal atrophy and pancreatic ductal stones with ductal dilation to 9mm.
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[] |
100339
| 10 |
Due to his young age and atypical presentation, he was referred for genetic testing and counselling.
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[] |
100339
| 11 |
He underwent genetic testing for various genes known to cause hereditary pancreatitis: CASR, CFTR, CTRC, PRSS1, SPINK1.
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[] |
100339
| 12 |
He tested positive for homozygous variant of SPINK1 (N34S) mutation.
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[] |
100339
| 13 |
Reflex testing of at-risk relatives confirmed that both of his parents were heterozygous carriers of the same SPINK1 (N34S) mutation and a review of their extended pedigree revealed that they were distant cousins.
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[] |
100339
| 14 |
Given his asymptomatic clinical course, he remains under close follow-up without requiring any specific treatment for pancreatic insufficiency.
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[] |
100339
| 15 |
Due to the severity of pancreatitis noted on imaging and long expected lifespan, he was counselled about the increased risk of pancreatic malignancy and is undergoing regular cross-sectional imaging for the detection and prevention of cancer.
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[] |
100345
| 1 |
A 20-year-old right-handed female factory worker with no medical history is consulting in the emergency ward with an open trauma of the left hand resulting from an occupational accident.
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[] |
100345
| 2 |
Her hand was crushed under a heavy object.
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[] |
100345
| 3 |
Physical examination found an important swelling and obvious distortion at the dorsum of the hand associated with wounds of the ulnar and radial edges of the left hand.
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[] |
100345
| 4 |
The neurovascular examination was normal; in particular no sensitive deficit in the median nerve area was noted.
|
[
[
"normal",
"examination"
]
] |
100345
| 5 |
Plain radiographs with front and lateral views showed a dislocation of the three lesser fingers associated with fractures of the hamatum and the second metacarpal.
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[] |
100345
| 6 |
The three lesser metacarpals and the distal fragment of the hamatum were medially displaced.
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[] |
100345
| 7 |
The patient was immediately brought to the operating theatre.
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[] |
100345
| 8 |
The treatment consisted of a reduction and stabilisation using a multiple carpo-metacarpal and cross inter-metacarpal pinning.
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[] |
100345
| 9 |
The wound was cleaned up trimmed and sutured.
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[] |
100345
| 10 |
The had and the wrist were immobilized with a splint for six weeks.
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[] |
100345
| 11 |
The patient had an intense and regular rehabilitation program.
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[] |
100345
| 12 |
At one year follow-up, the outcome is good: the patient is painless with good bone consolidation in right position, strictly normal range of motion (metacarpophalangeal 90°, proximal interphalagienne 100° and distal interphalageal 90°) and a 80% grip strength compared to the right side.
|
[
[
"90°",
"metacarpophalangeal"
],
[
"100°",
"interphalagienne"
],
[
"90°",
"interphalageal"
],
[
"80%",
"strength"
]
] |
100385
| 1 |
A 45 year old female with history of sickle cell disease presented with abdominal pain.
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[] |
100385
| 2 |
A CT scan revealed an exophytic renal mass measuring 2.9cm x 2.0cm x 2.1cm located on the antero-lateral aspect of her right kidney and an unremarkable spleen.
|
[
[
"2.9cm x 2.0cm x 2.1cm",
"measuring"
]
] |
100385
| 3 |
She was evaluated by urology and a right partial nephrectomy was planned, however on the day of the procedure, the patient's preoperative pregnancy test was positive.
|
[
[
"positive",
"test"
]
] |
100385
| 4 |
The procedure was post postponed until after she delivered and interval ultrasounds were obtained throughout her pregnancy to monitor the renal mass.
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[] |
100385
| 5 |
The lesion increased minimally in size.
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[] |
100385
| 6 |
Two months after caesarian section delivery, patient underwent an unremarkable right laparoscopic partial nephrectomy with individual artery and vein vascular occlusion at the level of the renal hilum.
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[] |
100385
| 7 |
A superficial liver laceration caused by the Veress needle was noted at the beginning of the procedure and effectively managed using bipolar cautery.
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[] |
100385
| 8 |
The patient's post-operative course was notable for marked thrombocytosis with her platelet count increasing for her baseline of 300,000 to a zenith of 1.3 million.
|
[
[
"300,000",
"count"
],
[
"1.3 million",
"count"
]
] |
100385
| 9 |
She was started on aspirin therapy and splenomegaly was noted on abdomen ultrasound.
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[] |
100385
| 10 |
Her platelet count normalized to 334,000.
|
[
[
"334,000",
"count"
]
] |
100385
| 11 |
On pathology, the renal mass was classified as a papillary renal neoplasm consistent with a translocation carcinoma.
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[] |
100385
| 12 |
There was no splenic tissue in the specimen.
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[] |
100385
| 13 |
It was noted that the complete lack of staining of any keratins or epithelial membrane antigens was not consistent with a usual renal cell carcinoma and hence the diagnosis of a translocation tumor was made.
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[] |
100385
| 14 |
The patient was lost to follow up presenting 2 years later and a follow-up CT scan noted marked splenic atrophy with several splenules.
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[] |
100385
| 15 |
The patient was completely asymptomatic and at the time received all the post-splenectomy vaccination and her platelet count remained within normal limits.
|
[
[
"within normal limits",
"count"
]
] |
100415
| 1 |
A 57 year old lady presented to a peripheral hospital with complaints of penetrating epigastric pain of a week’s duration.
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[] |
100415
| 2 |
There was no vomiting or weight loss.
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[] |
100415
| 3 |
Bowel movements were normal.
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[] |
100415
| 4 |
Clinical examination at the time was unrevealing.
|
[
[
"unrevealing",
"examination"
]
] |
100415
| 5 |
An abdominal ultrasound examination was reported as normal.
|
[
[
"normal",
"examination"
]
] |
100415
| 6 |
The patient’s insistence on full investigation of the persistent epigastric pain led to a computed tomographic examination and discovery of a pancreatic tumour subsequent to which she was referred to our institution.
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[] |
100415
| 7 |
The CT scan showed a large tumour (6cm in largest diameter) in the body and tail of pancreas with no evidence of metastasis.
|
[
[
"6cm",
"diameter"
]
] |
100415
| 8 |
She was prepared for exploratory laparotomy.
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[] |
100415
| 9 |
The pancreas was explored through the gastrocolic omentum.
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[] |
100415
| 10 |
The body and tail of the pancreas including the tumour were resected.
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[] |
100415
| 11 |
The spleen was also removed.
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[] |
100415
| 12 |
The end of the pancreas was suture ligated.
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[] |
100415
| 13 |
Her post-operative recovery was uneventful.
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[] |
100415
| 14 |
Histological examination of the specimen showed a well circumscribed ovoid tumour 60mm x 50mm across.
|
[
[
"60mm x 50mm across",
"tumour"
]
] |
100415
| 15 |
Sections revealed islands and trabeculae of regular cells with variable amounts of eosinophilic cytoplasm, mostly regular nuclei with indistinct nucleoli.
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[] |
100415
| 16 |
Areas of necrosis were present with hemorrhage.
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[] |
100415
| 17 |
A fibrous pseudo-capsule was noted around the tumour and the resection of the tumour appeared complete.
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[] |
100415
| 18 |
No capsular of vascular invasion was seen.
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[] |
100415
| 19 |
Immuno-peroxidase staining was positive for chromogranin A.
|
[
[
"positive",
"staining"
],
[
"positive",
"chromogranin"
]
] |
100415
| 20 |
Synaptophysin was strongly positive, CD10 was negative, Ki-67 was less than 2% positive and the mitotic count was between 2-20 per 10 hpf.
|
[
[
"strongly positive",
"Synaptophysin"
],
[
"negative",
"CD10"
],
[
"less than 2% positive",
"Ki-67"
],
[
"2-20 per 10 hpf",
"count"
]
] |
100415
| 21 |
The staining reactions were confirmatory of a neuroendocrine carcinoma of the pancreas.
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[] |
100415
| 22 |
The final staging of the completely excised tumour was T3 N0 M0.
|
[
[
"T3 N0 M0",
"staging"
]
] |
100415
| 23 |
Following discharge, she was followed up regularly and remains symptom free.
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[] |
100415
| 24 |
A CT Scan performed 2 years after surgery showed no evidence of tumour recurrence.
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[] |
100432
| 1 |
A 64-year-old woman was admitted to our institution with palpable lump in her left breast.
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[] |
100432
| 2 |
Patient had not any previous medical and family story of cancer and denied any use of alcohol and cigarettes.
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[] |
100432
| 3 |
She took oral contraception for 5 years.
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[] |
100432
| 4 |
Her menarche was at age 12.
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[] |
100432
| 5 |
Physical examination revealed a 3 cm tumor located on the left breast adhere to deep plans.
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[] |
100432
| 6 |
There was no retraction of the nipple, skin ulceration or inflammatory changes.
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[] |
100432
| 7 |
The right breast exam was negative and there was no clinical evidence of axillary lymph node involvement.
|
[
[
"negative",
"exam"
]
] |
100432
| 8 |
Mammography revealed a 2.6 cm round hyperdense mass with irregular and speculated margins in the subareolar area with associated microcalcifications within the mass.
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[] |
100432
| 9 |
The mass was categorized as Breast Imaging Reporting and Data System category 5.
|
[
[
"5",
"category"
]
] |
100432
| 10 |
Fine needle aspiration and a core biopsy of the lesion were performed and the diagnostic was tubular carcinoma of the breast.
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[] |
100432
| 11 |
The patient underwent left lumpectomy with axillary node dissection.
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[] |
100432
| 12 |
The macroscopic (gross) examination of specimens revealed the presence of a nodule measuring 1.5 cm in its largest diameter.
|
[
[
"1.5 cm",
"measuring"
],
[
"1.5 cm",
"diameter"
]
] |