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Random & Cluster simulation

Random & Cluster simulation includes DDI data for running benchmarking evaluation in DDI-Ben, where random refers random split of drugs and cluster refers using cluster-based strategy to conduct distribution change simulation.

Real Scene

Real_scene_drugbank includes DDI data from DrugBank, where drugs are divided into three sequential training-validation-test sets based on their market approval timeline.

Citation

If you find the data useful, please cite:

@article{shen2025benchmarking,
  title={Benchmarking drug-drug interaction prediction methods: a perspective of distribution changes},
  author={Shen, Zhenqian and Zhou, Mingyang and Zhang, Yongqi and Yao, Quanming},
  journal={Bioinformatics},
  year={2025},
  publisher={Oxford University Press},
  url={https://arxiv.org/abs/2410.18583}, 
}
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