bigbio/chemprot · Datasets at Hugging Face

pmid string	text string	entities sequence	relations sequence
10471277	Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol. Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma. In addition to binding at the active agonist site, it has been proposed that sa...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:5", "CPR:5", "CPR:2", "CPR:2", "CPR:2", "CPR:5", "CPR:5", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:6", "CPR:6", "CPR:2", "CPR:2", "CPR:2", "CPR:2" ], "arg1": [ "T30", "T31", "T32...
23150485	Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. The multidrug transporter, breast cancer resistance protein, ABCG2, is up-regulated in certain chemoresistant cancer cells and in the mammary gland during lactation. We investigated the role of the lactogenic hormone prolacti...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [], "arg1": [], "arg2": [] }
23155202	Influence of coadministration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats. Among the artemisinin-based combination therapy (ACT) regimens, artemisinin derivative, artemether in combination with lumefantrine (artemether-lumefantrine, AL) ha...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27" ], "type": [ ...	{ "type": [], "arg1": [], "arg2": [] }
23477624	Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study. Polycalcium is a mixture of Polycan and calcium lactate-gluconate 1:9 (w/w) with demonstrated antiosteoporosis activity in vitro and in vivo studies. These studies were a 4-week open-label, single-center ...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [], "arg1": [], "arg2": [] }
23044094	Establishment of an in vitro photoallergy test using NCTC2544 cells and IL-18 production. Differentiation between photoallergenic and phototoxic reactions induced by low molecular weight compounds represents a current problem. The use of keratinocytes as a potential tool for the detection of photoallergens as opposed t...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", ...	{ "type": [], "arg1": [], "arg2": [] }
23220749	Apomorphine is a bimodal modulator of TRPA1 channels. Apomorphine is a non-narcotic derivative of morphine, which acts as a dopamine agonist and is clinically used to treat "off-states" in patients suffering from Parkinson's disease. Adverse effects of apomorphine treatment include severe emesis and nausea, and ulcerat...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28" ], "ty...	{ "type": [ "CPR:2", "CPR:10", "CPR:10", "CPR:10", "CPR:10", "CPR:10", "CPR:10", "CPR:2", "CPR:4", "CPR:2", "CPR:2", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3" ], "arg1": [ "T13", "T9", "T9", "T9", "T9", "T9", "T9", "...
9950599	Oxidative stress induces differential gene expression in a human lens epithelial cell line. PURPOSE: To identify differentially expressed genes in a human lens epithelial cell line exposed to oxidative stress. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) differential display was used to evaluate di...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CH...	{ "type": [], "arg1": [], "arg2": [] }
23615073	Vitamin C forestalls cigarette smoke induced NF-κB activation in alveolar epithelial cells. Cigarette smoking causes cellular oxidative stress resulting in inflammatory diseases of lung wherein transcription factor NF-κB plays an important role. It is possible that vitamin C, an antioxidant, may prevent cigarette smoke...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24" ], "type": [ "CHEMICAL", "CHEMICAL", "...	{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:2", "CPR:2", "CPR:4", "CPR:4", "CPR:2", "CPR:4", "CPR:4" ], "arg1": [ "T8", "T4", "T4", "T4", "T4", "T7", "T7", "T7", "T2", "T3" ], "arg2": [ "T24", "T13", "T14", "T15", ...
23147415	Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. An impaired central cholinergic system is at least partly involved in Alzheimer's disease (AD) pathogenesis, with cholinergic markers such as acetylcholinesterase (AChE) activity and protein levels decreasing as cog...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25" ], "type": [ "CHEMICAL", "CHEMI...	{ "type": [ "CPR:9", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:9" ], "arg1": [ "T6", "T7", "T8", "T8", "T1", "T4", "T2", "T25" ], "arg2": [ "T18", "T19", "T20", "T21", "T9", "T9", "T9", "T9" ] }
23643664	Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up-regulation of parkin protein. Hypothalamic tuberoinfundibular dopamine (TIDA) neurons remain unaffected in Parkinson disease (PD) while there is significant degeneration ...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:10" ], "arg1": [ "T15", "T5", "T7", "T8", "T5", "T7", "T8...
17124432	Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism. Neuronal NE reuptake may be impaired in individuals with renal disease and/or hypertension due to dysfunction of...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICA...	{ "type": [ "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9" ], "arg1": [ "T6", "T6", "T7", "T7", "T2" ], "arg2": [ "T9", "T15", "T15", "T9", "T12" ] }
23562076	Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet. Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms are unclear. We report that mice deficient in the immune cell transcription factor T-bet have l...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "GENE-N", "GENE-N", "GENE-Y", "GENE-N", "GENE...	{ "type": [], "arg1": [], "arg2": [] }
23639738	Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Cholesterol esterase (CE) induced surface erosion of poly(ethylene carbonate) (PEC) and drug release from PEC under mild physiological environment was investigated. The degradation process was monitored by changes of mass and mol...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "C...	{ "type": [], "arg1": [], "arg2": [] }
12477282	Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Innate immune cells recognize pathogens by detecting molecular patterns that are distinct from those of the host. One such pattern is unmethylated CpG dinucleotides, which are common in bacterial DNA but not in v...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:3", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3" ], "arg1": [ "T16", "T14", "T14", "T14", "T14", "T14", "T4", "T3", "T1", "T1", ...
23339966	5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. A series of novel 5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones (3a-z) have been evaluated for in vitro cytotoxicity against a panel of 60...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y", "GENE-Y" ], "text": [ "5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones", "N", ...	{ "type": [], "arg1": [], "arg2": [] }
10998082	A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. BACKGROUND: The thrombotic process is a multicellular phenomenon in which not only platelets but also neutrophils are involved. Recent in vitro studies performed in our laboratory...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:3", "CPR:3", "CPR:10", "CPR:3", "CPR:10" ], "arg1": [ "T1", "T1", "T10", "T15", "T21" ], "arg2": [ "T36", "T37", "T38", "T40", "T41" ] }
12453616	Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. This study investigates the involvement of alpha(2)-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha(2A)-AR increased in the dentat...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GE...	{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:2" ], "arg1": [ "T6", "T6", "T1", "T1", "T2", "T2", "T3", "T5" ], "arg2": [ "T17", "T18", "T10", "T15", "T10", "T15", "T7", "T16" ] ...
6706930	Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. Mechanisms that have been proposed for peroxidase-catalyzed iodination require the utilization of 1 mol of H2O2 for organic binding of 1 mol of iodide. When we measured the stoichiometry of this reaction using thyroid peroxidase...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:2", "CPR:2", "CPR:8", "CPR:9", "CPR:9", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:2", "CPR:2", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CP...
23188391	Lipotoxicity impairs incretin signalling. The incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide are secreted by enteroendocrine cells and augment glucose-induced insulin secretion in response to food ingestion in a glucose-dependent manner. This mechanism forms the basis for increti...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-N", "GENE-Y", "GENE-Y", "GEN...	{ "type": [ "CPR:3", "CPR:3" ], "arg1": [ "T1", "T2" ], "arg2": [ "T6", "T6" ] }
9399970	Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. The purpose of this investigation was to evaluate the discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine. In pigeons trained to discriminate 1.7 mg/kg dezocin...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:2", "CPR:2", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:2", "CPR:10", "CPR:5" ], "arg1": [ "T24", "T26", "T27", "T28", "T29", "T30", "T31", "T32", "T33", "T34", "T45",...
23103563	Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells. There is growing evidence that aminobisphosphonates like ibandronate show anticancer activity by an unknown mechanism. Biochemically, they prevent posttranslational isoprenylation of small GTPases, thus inhibitin...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25" ], "type": [ "CHEMICAL", "CHEMI...	{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:10", "CPR:10", "CPR:2", "CPR:3" ], "arg1": [ "T11", "T8", "T8", "T9", "T9", "T10", "T10", "T1", "T1" ], "arg2": [ "T25", "T23", "T24", "T23", "T24", "T1...
23174265	Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. We have recently reported that selective cannabinoid 2 (CB(2)) receptor agonists upregulate 5-HT(2A) receptors by enhancing ERK1/2 signaling in prefrontal cortex (PFCx). Increased activity o...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:6", "CPR:6", "CPR:6", "CPR:4" ], "arg1": [ "T3", "T3", "T3", "T3", "T4", "T4", "T4", "T4" ], "arg2": [ "T22", "T23", "T24", "T25", "T28", "T26", "T29", "T27" ]...
23103450	Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression. The human ether-a-go-go-related gene (hERG) encodes the rapidly activating, delayed rectifier potassium channel (IKr) important for cardiac repolarization. Dysfunctio...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:3", "CP...
7768269	Discriminative stimulus effects of esteratic local anesthetics in squirrel monkeys. A number of esteratic local anesthetics serve as positive reinforcers and produce cocaine-like discriminative stimulus effects in animals. It has been suggested that the affinity of these compounds for a site on the dopamine transporter...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:6", "CPR:6", "CPR:6" ], "arg1": [ "T23", "T24", "T26" ], "arg2": [ "T28", "T28", "T29" ] }
15967876	Intracellular K+ is required for the inactivation-induced high-affinity binding of cisapride to HERG channels. Many commonly used medications can cause long QT syndrome and thus increase the risk of life-threatening arrhythmias. High-affinity human Ether-a-go-go-related gene (HERG) potassium channel blockade by structu...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:2", "CPR:2", "CPR:4", "CPR:2", "CPR:2", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:4", "CPR:9", "CPR:4", "CPR:9", "CPR:4", "CPR:1" ], "arg1": [ "T12", "T11", "T7", "T8", ...
17251447	RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice. PURPOSE: Phototransduction in cones is initiated by the bleaching of their visual pigment, which comprises a protein component-cone opsin-and a vitamin A derivative-11-cis retinal. Little is known about the source of 11-cis retinal for co...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [], "arg1": [], "arg2": [] }
23360475	Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. The natural product tryptanthrin (1a) represents a potential lead for new tuberculosis (TB) drugs since tryptanthrin and its synthetic analogues possess potent in vitro activity against Mycobacterium tuberculosis (...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL" ], "text": [ "tryptanthrin", "tryptanthrin", "tryptanthrin", "tryptanthrin", "tryptanth...	{ "type": [], "arg1": [], "arg2": [] }
15110853	Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity. A series of aromatic/heterocyclic sulfonamides incorporating adamantyl moieties were prepared by reaction of aromatic/heterocyclic aminosulfonamides with the acyl chlorides derived...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICA...	{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4" ], "arg1": [ "T12", "T13", "T9", "T9", "T9", "T11", "T11", "T11" ], "arg2": [ "T19", "T19", "T14", "T15", "T16", "T14", "T15", "T16...
23578391	Perinatal exposure to BDE-99 causes learning disorders and decreases serum thyroid hormone levels and BDNF gene expression in hippocampus in rat offspring. Exposure of pregnant women to polybrominated diphenyl ethers (PBDEs) may mean serious health risks. The main goal of the present study was to examine the neurobehav...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", ...	{ "type": [ "CPR:4" ], "arg1": [ "T12" ], "arg2": [ "T20" ] }
23432095	Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivatio...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:9", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:2", "CPR:2", "CPR:9", "CPR:9", "CPR:10", "CPR:10" ], "arg1": [ "T11", "T11", "T11", "T4", "T6", "T6", "T7", "T7", "T9", "T10", ...
23613080	Hierarchical NiO microflake films with high coloration efficiency, cyclic stability and low power consumption for applications in a complementary electrochromic device. We have demonstrated that thin films of hierarchical NiO microflakes assembled from nanoleaves can be grown directly on FTO-coated glass substrates usi...	{ "id": [ "T1", "T2", "T3", "T4", "T5" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL" ], "text": [ "FTO", "NiO", "NiO", "WO3", "NiO" ], "offsets": [ [ 289, 292 ], [ 222, 225 ], ...	{ "type": [], "arg1": [], "arg2": [] }
15132128	Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. PURPOSE: The fluoropyrimidine carbamate (capecitabine) is converted to 5-fluorouracil (5-FU) by thymidine phosphorylase (TP) in...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:4", "CPR:4", "CPR:9", "CPR:9" ], "arg1": [ "T2", "T8", "T2", "T8", "T10", "T11", "T10", "T11", "T3", "T3", "T3", "T3" ], "arg...
23576111	Protective effects of green tea on antioxidative biomarkers in chemical laboratory workers. Chemical materials are environmental contaminants, are extensively used in laboratories, and may cause various forms of health hazards in laboratory workers. Therefore, this toxicity most likely is a result of the oxidative meta...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11" ], "type": [ "CHEMICAL", "CHEMICAL", "GENE-N", "GENE-Y", "GENE-N", "GENE-N", "GENE-Y", "GENE-Y", "GENE-N", "GENE-N", "GENE-N" ], "text": [ "g...	{ "type": [], "arg1": [], "arg2": [] }
6645495	Binding of progestagens to receptor proteins in MCF-7 cells. With the aim of finding an explanation for the biological properties of progestagens currently used for contraceptive purposes, we have assessed their specificity for progesterone, androgen and oestrogen receptors in MCF-7 cells. The specificity of progestage...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2" ], "...
19428322	AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. We investigated the effect of compound C, a well-known inhibitor of the intracellular energy sensor AMP-activated protein kinase (AMPK), on proliferation and viability of human U251 and rat C6 glioma ...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25" ], "type": [ "CHEMICAL", "CHEMI...	{ "type": [ "CPR:2", "CPR:4", "CPR:4", "CPR:3", "CPR:4", "CPR:10", "CPR:4", "CPR:3", "CPR:3", "CPR:4", "CPR:4" ], "arg1": [ "T18", "T19", "T19", "T20", "T21", "T21", "T22", "T4", "T5", "T25", "T22" ], "arg2": [ "T17", ...
14766200	Expression of DDAH1 in chick and rat embryos. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is an enzyme that metabolizes methylated arginine to citrulline and methylamine, thus working to produce nitric oxide (NO). We isolated a gene encoding chick DDAH1. In situ hybridization analysis revealed characteristic DDAH...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", ...	{ "type": [ "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9" ], "arg1": [ "T20", "T20", "T2", "T2", "T3", "T3" ], "arg2": [ "T7", "T12", "T12", "T7", "T7", "T12" ] }
23110812	SPIDIA-RNA: first external quality assessment for the pre-analytical phase of blood samples used for RNA based analyses. The diagnostic use of in vitro molecular assays can be limited by the lack of guidelines for collection, handling, stabilization and storage of patient specimens. One of the major goals of the EC fun...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6" ], "type": [ "CHEMICAL", "GENE-Y", "GENE-Y", "GENE-Y", "GENE-Y", "GENE-Y" ], "text": [ "EDTA", "GAPDH", "c-fos", "IL-1β", "IL-8", "GAPDH" ], "offsets": [ [ 1147, 1151 ],...	{ "type": [], "arg1": [], "arg2": [] }
17484506	Endometriosis: the way forward. Endometriosis, a common cause of morbidity, affects 10% of women of reproductive age. In this review we focus on the new developments in pathogenesis, diagnosis and treatment options, reviewing the literature published about this enigmatic disorder over the past three years. More specifi...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-N", "GENE-Y", "GENE-N" ], "text": [ "levonorgestrel", "estrogen", "progesterone", "gonadotropin-releasing hormone", "aromatase", "estrogen...	{ "type": [], "arg1": [], "arg2": [] }
23494186	LDL Cholesterol Goals in High-Risk Patients: How Low Do We Go and How Do We Get There? It is widely recognised that low-density lipoprotein cholesterol (LDL-C) is one of the most important and modifiable risk factors for cardiovascular disease (CVD). Statins (HMG-CoA reductase inhibitors) have consistently been shown t...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y", "GENE-N", "GENE-N"...	{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4" ], "arg1": [ "T3", "T4", "T5", "T3", "T4", "T5" ], "arg2": [ "T10", "T10", "T10", "T11", "T11", "T11" ] }
23195959	Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response. AKT is a critical effector kinase downstream of the PI3K pathway that regulates a plethora of cellular processes including cell growth, death, differentiation, and migration. Mechani...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [], "arg1": [], "arg2": [] }
23611835	Molecular Mechanisms of the antitumor activity of SB225002: A novel microtubule inhibitor. SB225002 (SB) is an IL-8 receptor B (IL-8RB) antagonist that has previously been shown to inhibit IL-8-based cancer cell invasion, and to possess in vivo anti-inflammatory and anti-nociceptive effects. The present study presented...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMIC...	{ "type": [ "CPR:6", "CPR:6", "CPR:2", "CPR:6", "CPR:2" ], "arg1": [ "T1", "T1", "T2", "T3", "T1" ], "arg2": [ "T14", "T16", "T20", "T21", "T22" ] }
10403635	Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. The acute toxicity of organophosphorus (OP) compounds in mammals is due to their irreversible inhibition of acetylcholinesterase (AChE) in the nervous system, which leads to increased synaptic acetylcho...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:3", "CPR:4", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4" ], "arg1": [ "T8", "T11", "T10", "T55", "T55", "T20", "T20", "T9" ], "arg2": [ "T43", "T45", "T45", "T40", "T42", "T40", "T42", "T4...
23562072	Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased A...	{ "id": [ "T1", "T2", "T3", "T4", "T5" ], "type": [ "CHEMICAL", "CHEMICAL", "GENE-Y", "GENE-N", "GENE-N" ], "text": [ "cholesterol", "cholesterol", "ABCA1", "liver X receptor", "miR-33" ], "offsets": [ [ 411, 422 ], [ ...	{ "type": [], "arg1": [], "arg2": [] }
23402744	Sexually dimorphic behavior after developmental exposure to characterize endocrine-mediated effects of different non-dioxin-like PCBs in rats. Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differe...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27" ], "type": [ ...	{ "type": [ "CPR:4", "CPR:4" ], "arg1": [ "T15", "T16" ], "arg2": [ "T26", "T26" ] }
23538162	Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis. The deposition of β-amyloid (Aβ) in neurons and vascular cells of the brain has been characterized in Alzheimer's disease. Ginsenoside Rg1 (Rg1) is an a...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:4", "CPR:4", "CPR:6", "CPR:6", "CPR:4", "CPR:6", "CPR:2", "CPR:2", "CPR:4", "CPR:2", "CPR:2" ], "arg1": [ "T5", "T5", "T7", "T7", "T8", "T10", "T11", "T11", "T11", "T1", "T1" ], "arg2": [ "T19", "T...
23458420	Thioflavin T and its photoirradiative derivatives: exploring their spectroscopic properties in the absence and presence of amyloid fibrils. In this work, we found that, during storage or after UV irradiation, ThT is demethylated or oxidized, forming three derivatives. These three derivatives were purified by high perfo...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y" ], "text": [ "ThT", "T...	{ "type": [], "arg1": [], "arg2": [] }
15204055	Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors? It is well documented that atypical antipsychotics have an influence on cognitive function in patients with schizophrenia, although the neurochemical basis for this effect is not well understood. One suggestion is tha...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", ...	{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2" ], "arg1": [ "T7", "T8", "T9", "T10", "T11", "T7", "T8", "T9", "T10", ...
23409951	Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice. Abstract 1. Arsenic (As(III)) toxicity has received increasing attention as human exposure to arsenic is associated with pulmonary, hepatic and renal toxicities. Therefore, in the present...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...	{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:3", "CPR:3" ], "arg1": [ "T22", "T11", "T11", "T11", "T11", "T11", "T20", "T3" ], "arg2": [ "T32", "T26", "T27", "T28", "T29", "T30", "T31", "T...
23063069	Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos. Determination of toxicity of complex mixtures has been proposed to be one of the most important challenges for modern toxicology. In this study we performed genome wide transcriptome profiling to...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y", "...	{ "type": [], "arg1": [], "arg2": [] }
23620436	A New Proposed Rodent Model of Chemically Induced Prostate Carcinogenesis: Distinct Time-Course Prostate Cancer Progression in the Dorsolateral and Ventral Lobes. BACKGROUND: Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as we...	{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-N", ...	{ "type": [ "CPR:4", "CPR:3" ], "arg1": [ "T3", "T3" ], "arg2": [ "T10", "T11" ] }

10471277

Probing the salmeterol binding site on the beta 2-adrenergic receptor using a novel photoaffinity ligand, [(125)I]iodoazidosalmeterol. Salmeterol is a long-acting beta2-adrenergic receptor (beta 2AR) agonist used clinically to treat asthma. In addition to binding at the active agonist site, it has been proposed that sa...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:5", "CPR:5", "CPR:2", "CPR:2", "CPR:2", "CPR:5", "CPR:5", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:6", "CPR:6", "CPR:2", "CPR:2", "CPR:2", "CPR:2" ], "arg1": [ "T30", "T31", "T32...

23150485

Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. The multidrug transporter, breast cancer resistance protein, ABCG2, is up-regulated in certain chemoresistant cancer cells and in the mammary gland during lactation. We investigated the role of the lactogenic hormone prolacti...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [], "arg1": [], "arg2": [] }

23155202

Influence of coadministration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats. Among the artemisinin-based combination therapy (ACT) regimens, artemisinin derivative, artemether in combination with lumefantrine (artemether-lumefantrine, AL) ha...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27" ], "type": [ ...

{ "type": [], "arg1": [], "arg2": [] }

23477624

Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study. Polycalcium is a mixture of Polycan and calcium lactate-gluconate 1:9 (w/w) with demonstrated antiosteoporosis activity in vitro and in vivo studies. These studies were a 4-week open-label, single-center ...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [], "arg1": [], "arg2": [] }

23044094

Establishment of an in vitro photoallergy test using NCTC2544 cells and IL-18 production. Differentiation between photoallergenic and phototoxic reactions induced by low molecular weight compounds represents a current problem. The use of keratinocytes as a potential tool for the detection of photoallergens as opposed t...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", ...

{ "type": [], "arg1": [], "arg2": [] }

23220749

Apomorphine is a bimodal modulator of TRPA1 channels. Apomorphine is a non-narcotic derivative of morphine, which acts as a dopamine agonist and is clinically used to treat "off-states" in patients suffering from Parkinson's disease. Adverse effects of apomorphine treatment include severe emesis and nausea, and ulcerat...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28" ], "ty...

{ "type": [ "CPR:2", "CPR:10", "CPR:10", "CPR:10", "CPR:10", "CPR:10", "CPR:10", "CPR:2", "CPR:4", "CPR:2", "CPR:2", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3" ], "arg1": [ "T13", "T9", "T9", "T9", "T9", "T9", "T9", "...

9950599

Oxidative stress induces differential gene expression in a human lens epithelial cell line. PURPOSE: To identify differentially expressed genes in a human lens epithelial cell line exposed to oxidative stress. METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) differential display was used to evaluate di...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CH...

{ "type": [], "arg1": [], "arg2": [] }

23615073

Vitamin C forestalls cigarette smoke induced NF-κB activation in alveolar epithelial cells. Cigarette smoking causes cellular oxidative stress resulting in inflammatory diseases of lung wherein transcription factor NF-κB plays an important role. It is possible that vitamin C, an antioxidant, may prevent cigarette smoke...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24" ], "type": [ "CHEMICAL", "CHEMICAL", "...

{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:2", "CPR:2", "CPR:4", "CPR:4", "CPR:2", "CPR:4", "CPR:4" ], "arg1": [ "T8", "T4", "T4", "T4", "T4", "T7", "T7", "T7", "T2", "T3" ], "arg2": [ "T24", "T13", "T14", "T15", ...

23147415

Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. An impaired central cholinergic system is at least partly involved in Alzheimer's disease (AD) pathogenesis, with cholinergic markers such as acetylcholinesterase (AChE) activity and protein levels decreasing as cog...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25" ], "type": [ "CHEMICAL", "CHEMI...

{ "type": [ "CPR:9", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:9" ], "arg1": [ "T6", "T7", "T8", "T8", "T1", "T4", "T2", "T25" ], "arg2": [ "T18", "T19", "T20", "T21", "T9", "T9", "T9", "T9" ] }

23643664

Sustained resistance to acute MPTP toxicity by hypothalamic dopamine neurons following chronic neurotoxicant exposure is associated with sustained up-regulation of parkin protein. Hypothalamic tuberoinfundibular dopamine (TIDA) neurons remain unaffected in Parkinson disease (PD) while there is significant degeneration ...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:10" ], "arg1": [ "T15", "T5", "T7", "T8", "T5", "T7", "T8...

17124432

Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism. Neuronal NE reuptake may be impaired in individuals with renal disease and/or hypertension due to dysfunction of...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICA...

{ "type": [ "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9" ], "arg1": [ "T6", "T6", "T7", "T7", "T2" ], "arg2": [ "T9", "T15", "T15", "T9", "T12" ] }

23562076

Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet. Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms are unclear. We report that mice deficient in the immune cell transcription factor T-bet have l...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "GENE-N", "GENE-N", "GENE-Y", "GENE-N", "GENE...

{ "type": [], "arg1": [], "arg2": [] }

23639738

Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. Cholesterol esterase (CE) induced surface erosion of poly(ethylene carbonate) (PEC) and drug release from PEC under mild physiological environment was investigated. The degradation process was monitored by changes of mass and mol...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "C...

{ "type": [], "arg1": [], "arg2": [] }

12477282

Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Innate immune cells recognize pathogens by detecting molecular patterns that are distinct from those of the host. One such pattern is unmethylated CpG dinucleotides, which are common in bacterial DNA but not in v...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:3", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3" ], "arg1": [ "T16", "T14", "T14", "T14", "T14", "T14", "T4", "T3", "T1", "T1", ...

23339966

5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties. A series of novel 5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones (3a-z) have been evaluated for in vitro cytotoxicity against a panel of 60...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y", "GENE-Y" ], "text": [ "5-((1-aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones", "N", ...

{ "type": [], "arg1": [], "arg2": [] }

10998082

A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils: role in platelet function. BACKGROUND: The thrombotic process is a multicellular phenomenon in which not only platelets but also neutrophils are involved. Recent in vitro studies performed in our laboratory...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:3", "CPR:3", "CPR:10", "CPR:3", "CPR:10" ], "arg1": [ "T1", "T1", "T10", "T15", "T21" ], "arg2": [ "T36", "T37", "T38", "T40", "T41" ] }

12453616

Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. This study investigates the involvement of alpha(2)-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha(2A)-AR increased in the dentat...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GE...

{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:2" ], "arg1": [ "T6", "T6", "T1", "T1", "T2", "T2", "T3", "T5" ], "arg2": [ "T17", "T18", "T10", "T15", "T10", "T15", "T7", "T16" ] ...

6706930

Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. Mechanisms that have been proposed for peroxidase-catalyzed iodination require the utilization of 1 mol of H2O2 for organic binding of 1 mol of iodide. When we measured the stoichiometry of this reaction using thyroid peroxidase...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:2", "CPR:2", "CPR:8", "CPR:9", "CPR:9", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:2", "CPR:2", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CP...

23188391

Lipotoxicity impairs incretin signalling. The incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide are secreted by enteroendocrine cells and augment glucose-induced insulin secretion in response to food ingestion in a glucose-dependent manner. This mechanism forms the basis for increti...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-N", "GENE-Y", "GENE-Y", "GEN...

{ "type": [ "CPR:3", "CPR:3" ], "arg1": [ "T1", "T2" ], "arg2": [ "T6", "T6" ] }

9399970

Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. The purpose of this investigation was to evaluate the discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine. In pigeons trained to discriminate 1.7 mg/kg dezocin...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:2", "CPR:2", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:5", "CPR:2", "CPR:10", "CPR:5" ], "arg1": [ "T24", "T26", "T27", "T28", "T29", "T30", "T31", "T32", "T33", "T34", "T45",...

23103563

Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells. There is growing evidence that aminobisphosphonates like ibandronate show anticancer activity by an unknown mechanism. Biochemically, they prevent posttranslational isoprenylation of small GTPases, thus inhibitin...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25" ], "type": [ "CHEMICAL", "CHEMI...

{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:10", "CPR:10", "CPR:2", "CPR:3" ], "arg1": [ "T11", "T8", "T8", "T9", "T9", "T10", "T10", "T1", "T1" ], "arg2": [ "T25", "T23", "T24", "T23", "T24", "T1...

23174265

Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. We have recently reported that selective cannabinoid 2 (CB(2)) receptor agonists upregulate 5-HT(2A) receptors by enhancing ERK1/2 signaling in prefrontal cortex (PFCx). Increased activity o...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:6", "CPR:6", "CPR:6", "CPR:4" ], "arg1": [ "T3", "T3", "T3", "T3", "T4", "T4", "T4", "T4" ], "arg2": [ "T22", "T23", "T24", "T25", "T28", "T26", "T29", "T27" ]...

23103450

Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expression. The human ether-a-go-go-related gene (hERG) encodes the rapidly activating, delayed rectifier potassium channel (IKr) important for cardiac repolarization. Dysfunctio...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:3", "CPR:4", "CPR:4", "CPR:3", "CP...

7768269

Discriminative stimulus effects of esteratic local anesthetics in squirrel monkeys. A number of esteratic local anesthetics serve as positive reinforcers and produce cocaine-like discriminative stimulus effects in animals. It has been suggested that the affinity of these compounds for a site on the dopamine transporter...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:6", "CPR:6", "CPR:6" ], "arg1": [ "T23", "T24", "T26" ], "arg2": [ "T28", "T28", "T29" ] }

15967876

Intracellular K+ is required for the inactivation-induced high-affinity binding of cisapride to HERG channels. Many commonly used medications can cause long QT syndrome and thus increase the risk of life-threatening arrhythmias. High-affinity human Ether-a-go-go-related gene (HERG) potassium channel blockade by structu...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:2", "CPR:2", "CPR:4", "CPR:2", "CPR:2", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:4", "CPR:9", "CPR:4", "CPR:9", "CPR:4", "CPR:1" ], "arg1": [ "T12", "T11", "T7", "T8", ...

17251447

RPE65 is essential for the function of cone photoreceptors in NRL-deficient mice. PURPOSE: Phototransduction in cones is initiated by the bleaching of their visual pigment, which comprises a protein component-cone opsin-and a vitamin A derivative-11-cis retinal. Little is known about the source of 11-cis retinal for co...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [], "arg1": [], "arg2": [] }

23360475

Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. The natural product tryptanthrin (1a) represents a potential lead for new tuberculosis (TB) drugs since tryptanthrin and its synthetic analogues possess potent in vitro activity against Mycobacterium tuberculosis (...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL" ], "text": [ "tryptanthrin", "tryptanthrin", "tryptanthrin", "tryptanthrin", "tryptanth...

{ "type": [], "arg1": [], "arg2": [] }

15110853

Carbonic anhydrase inhibitors: aromatic and heterocyclic sulfonamides incorporating adamantyl moieties with strong anticonvulsant activity. A series of aromatic/heterocyclic sulfonamides incorporating adamantyl moieties were prepared by reaction of aromatic/heterocyclic aminosulfonamides with the acyl chlorides derived...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICA...

{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4" ], "arg1": [ "T12", "T13", "T9", "T9", "T9", "T11", "T11", "T11" ], "arg2": [ "T19", "T19", "T14", "T15", "T16", "T14", "T15", "T16...

23578391

Perinatal exposure to BDE-99 causes learning disorders and decreases serum thyroid hormone levels and BDNF gene expression in hippocampus in rat offspring. Exposure of pregnant women to polybrominated diphenyl ethers (PBDEs) may mean serious health risks. The main goal of the present study was to examine the neurobehav...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", ...

{ "type": [ "CPR:4" ], "arg1": [ "T12" ], "arg2": [ "T20" ] }

23432095

Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivatio...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:9", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:2", "CPR:2", "CPR:9", "CPR:9", "CPR:10", "CPR:10" ], "arg1": [ "T11", "T11", "T11", "T4", "T6", "T6", "T7", "T7", "T9", "T10", ...

23613080

Hierarchical NiO microflake films with high coloration efficiency, cyclic stability and low power consumption for applications in a complementary electrochromic device. We have demonstrated that thin films of hierarchical NiO microflakes assembled from nanoleaves can be grown directly on FTO-coated glass substrates usi...

{ "id": [ "T1", "T2", "T3", "T4", "T5" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL" ], "text": [ "FTO", "NiO", "NiO", "WO3", "NiO" ], "offsets": [ [ 289, 292 ], [ 222, 225 ], ...

{ "type": [], "arg1": [], "arg2": [] }

15132128

Enzyme expression profiles suggest the novel tumor-activated fluoropyrimidine carbamate capecitabine (Xeloda) might be effective against papillary thyroid cancers of children and young adults. PURPOSE: The fluoropyrimidine carbamate (capecitabine) is converted to 5-fluorouracil (5-FU) by thymidine phosphorylase (TP) in...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:4", "CPR:4", "CPR:9", "CPR:9" ], "arg1": [ "T2", "T8", "T2", "T8", "T10", "T11", "T10", "T11", "T3", "T3", "T3", "T3" ], "arg...

23576111

Protective effects of green tea on antioxidative biomarkers in chemical laboratory workers. Chemical materials are environmental contaminants, are extensively used in laboratories, and may cause various forms of health hazards in laboratory workers. Therefore, this toxicity most likely is a result of the oxidative meta...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11" ], "type": [ "CHEMICAL", "CHEMICAL", "GENE-N", "GENE-Y", "GENE-N", "GENE-N", "GENE-Y", "GENE-Y", "GENE-N", "GENE-N", "GENE-N" ], "text": [ "g...

{ "type": [], "arg1": [], "arg2": [] }

6645495

Binding of progestagens to receptor proteins in MCF-7 cells. With the aim of finding an explanation for the biological properties of progestagens currently used for contraceptive purposes, we have assessed their specificity for progesterone, androgen and oestrogen receptors in MCF-7 cells. The specificity of progestage...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2" ], "...

19428322

AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. We investigated the effect of compound C, a well-known inhibitor of the intracellular energy sensor AMP-activated protein kinase (AMPK), on proliferation and viability of human U251 and rat C6 glioma ...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25" ], "type": [ "CHEMICAL", "CHEMI...

{ "type": [ "CPR:2", "CPR:4", "CPR:4", "CPR:3", "CPR:4", "CPR:10", "CPR:4", "CPR:3", "CPR:3", "CPR:4", "CPR:4" ], "arg1": [ "T18", "T19", "T19", "T20", "T21", "T21", "T22", "T4", "T5", "T25", "T22" ], "arg2": [ "T17", ...

14766200

Expression of DDAH1 in chick and rat embryos. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is an enzyme that metabolizes methylated arginine to citrulline and methylamine, thus working to produce nitric oxide (NO). We isolated a gene encoding chick DDAH1. In situ hybridization analysis revealed characteristic DDAH...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", ...

{ "type": [ "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9", "CPR:9" ], "arg1": [ "T20", "T20", "T2", "T2", "T3", "T3" ], "arg2": [ "T7", "T12", "T12", "T7", "T7", "T12" ] }

23110812

SPIDIA-RNA: first external quality assessment for the pre-analytical phase of blood samples used for RNA based analyses. The diagnostic use of in vitro molecular assays can be limited by the lack of guidelines for collection, handling, stabilization and storage of patient specimens. One of the major goals of the EC fun...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6" ], "type": [ "CHEMICAL", "GENE-Y", "GENE-Y", "GENE-Y", "GENE-Y", "GENE-Y" ], "text": [ "EDTA", "GAPDH", "c-fos", "IL-1β", "IL-8", "GAPDH" ], "offsets": [ [ 1147, 1151 ],...

{ "type": [], "arg1": [], "arg2": [] }

17484506

Endometriosis: the way forward. Endometriosis, a common cause of morbidity, affects 10% of women of reproductive age. In this review we focus on the new developments in pathogenesis, diagnosis and treatment options, reviewing the literature published about this enigmatic disorder over the past three years. More specifi...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-N", "GENE-Y", "GENE-N" ], "text": [ "levonorgestrel", "estrogen", "progesterone", "gonadotropin-releasing hormone", "aromatase", "estrogen...

{ "type": [], "arg1": [], "arg2": [] }

23494186

LDL Cholesterol Goals in High-Risk Patients: How Low Do We Go and How Do We Get There? It is widely recognised that low-density lipoprotein cholesterol (LDL-C) is one of the most important and modifiable risk factors for cardiovascular disease (CVD). Statins (HMG-CoA reductase inhibitors) have consistently been shown t...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y", "GENE-N", "GENE-N"...

{ "type": [ "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4" ], "arg1": [ "T3", "T4", "T5", "T3", "T4", "T5" ], "arg2": [ "T10", "T10", "T10", "T11", "T11", "T11" ] }

23195959

Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response. AKT is a critical effector kinase downstream of the PI3K pathway that regulates a plethora of cellular processes including cell growth, death, differentiation, and migration. Mechani...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [], "arg1": [], "arg2": [] }

23611835

Molecular Mechanisms of the antitumor activity of SB225002: A novel microtubule inhibitor. SB225002 (SB) is an IL-8 receptor B (IL-8RB) antagonist that has previously been shown to inhibit IL-8-based cancer cell invasion, and to possess in vivo anti-inflammatory and anti-nociceptive effects. The present study presented...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMIC...

{ "type": [ "CPR:6", "CPR:6", "CPR:2", "CPR:6", "CPR:2" ], "arg1": [ "T1", "T1", "T2", "T3", "T1" ], "arg2": [ "T14", "T16", "T20", "T21", "T22" ] }

10403635

Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. The acute toxicity of organophosphorus (OP) compounds in mammals is due to their irreversible inhibition of acetylcholinesterase (AChE) in the nervous system, which leads to increased synaptic acetylcho...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:3", "CPR:4", "CPR:3", "CPR:4", "CPR:4", "CPR:4", "CPR:4", "CPR:4" ], "arg1": [ "T8", "T11", "T10", "T55", "T55", "T20", "T20", "T9" ], "arg2": [ "T43", "T45", "T45", "T40", "T42", "T40", "T42", "T4...

23562072

Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased A...

{ "id": [ "T1", "T2", "T3", "T4", "T5" ], "type": [ "CHEMICAL", "CHEMICAL", "GENE-Y", "GENE-N", "GENE-N" ], "text": [ "cholesterol", "cholesterol", "ABCA1", "liver X receptor", "miR-33" ], "offsets": [ [ 411, 422 ], [ ...

{ "type": [], "arg1": [], "arg2": [] }

23402744

Sexually dimorphic behavior after developmental exposure to characterize endocrine-mediated effects of different non-dioxin-like PCBs in rats. Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differe...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27" ], "type": [ ...

{ "type": [ "CPR:4", "CPR:4" ], "arg1": [ "T15", "T16" ], "arg2": [ "T26", "T26" ] }

23538162

Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis. The deposition of β-amyloid (Aβ) in neurons and vascular cells of the brain has been characterized in Alzheimer's disease. Ginsenoside Rg1 (Rg1) is an a...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:4", "CPR:4", "CPR:6", "CPR:6", "CPR:4", "CPR:6", "CPR:2", "CPR:2", "CPR:4", "CPR:2", "CPR:2" ], "arg1": [ "T5", "T5", "T7", "T7", "T8", "T10", "T11", "T11", "T11", "T1", "T1" ], "arg2": [ "T19", "T...

23458420

Thioflavin T and its photoirradiative derivatives: exploring their spectroscopic properties in the absence and presence of amyloid fibrils. In this work, we found that, during storage or after UV irradiation, ThT is demethylated or oxidized, forming three derivatives. These three derivatives were purified by high perfo...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y" ], "text": [ "ThT", "T...

{ "type": [], "arg1": [], "arg2": [] }

15204055

Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors? It is well documented that atypical antipsychotics have an influence on cognitive function in patients with schizophrenia, although the neurochemical basis for this effect is not well understood. One suggestion is tha...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", ...

{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2" ], "arg1": [ "T7", "T8", "T9", "T10", "T11", "T7", "T8", "T9", "T10", ...

23409951

Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice. Abstract 1. Arsenic (As(III)) toxicity has received increasing attention as human exposure to arsenic is associated with pulmonary, hepatic and renal toxicities. Therefore, in the present...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17", "T18", "T19", "T20", "T21", "T22", "T23", "T24", "T25", "T26", "T27", "T28", "T29"...

{ "type": [ "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:2", "CPR:3", "CPR:3" ], "arg1": [ "T22", "T11", "T11", "T11", "T11", "T11", "T20", "T3" ], "arg2": [ "T32", "T26", "T27", "T28", "T29", "T30", "T31", "T...

23063069

Parental exposure to natural mixtures of POPs reduced embryo production and altered gene transcription in zebrafish embryos. Determination of toxicity of complex mixtures has been proposed to be one of the most important challenges for modern toxicology. In this study we performed genome wide transcriptome profiling to...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-Y", "...

{ "type": [], "arg1": [], "arg2": [] }

23620436

A New Proposed Rodent Model of Chemically Induced Prostate Carcinogenesis: Distinct Time-Course Prostate Cancer Progression in the Dorsolateral and Ventral Lobes. BACKGROUND: Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as we...

{ "id": [ "T1", "T2", "T3", "T4", "T5", "T6", "T7", "T8", "T9", "T10", "T11", "T12", "T13", "T14", "T15", "T16", "T17" ], "type": [ "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "CHEMICAL", "GENE-N", ...

{ "type": [ "CPR:4", "CPR:3" ], "arg1": [ "T3", "T3" ], "arg2": [ "T10", "T11" ] }

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