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license: mit |
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# Dataset Description |
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## Dataset Summary |
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This dataset was parsed from the Human-HIV Interaction dataset maintained by the NCBI. |
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It contains a >16,000 pairs of interactions between HIV and Human proteins. |
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Sequences of the interacting proteins were retrieved from the NCBI protein database and added to the dataset. |
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The raw data is available from the [NBCI FTP site](https://ftp.ncbi.nlm.nih.gov/gene/GeneRIF/hiv_interactions.gz) and the curation strategy is described in the [NAR Research paper](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383939/) announcing the dataset. |
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## Dataset Structure |
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### Data Instances |
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Data Fields: hiv_protein_product, hiv_protein_name, interaction_type, human_protein_product, human_protein_name, reference_list, description, hiv_protein_sequence, human_protein_sequence |
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Data Splits: None |
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## Dataset Creation |
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Curation Rationale: This dataset was curated train models to recognize proteins that interact with HIV. |
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Initial Data Collection and Normalization: Dataset was downloaded and curated on 4/4/2022 but the most recent update of the underlying NCBI database was 2016. |
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## Considerations for Using the Data |
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Discussion of Biases: This dataset of protein interactions was manually curated by experts utilizing published scientific literature. |
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This inherently biases the collection to well-studied proteins and known interactions. |
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The dataset does not contain _negative_ interactions. |
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## Additional Information: |
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- Dataset Curators: Will Dampier |
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- Citation Information: TBA |
