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Getting the DID number from a CallCentric SIP trunk for FreePBX
I’ve got a few DDI numbers from CallCentric all around the world (UK, US, Australia) and couldn’t figure our how to setup an ‘Inbound Route’ in FreePBX that used the number that had been dialled to route the call.
It turns out that you need to extract the number from the ‘SIP header’ information and there’s no setting in FreePBX to do this so it means hacking at the Asterisk config files just a little.
There are a few methods for doing this but these instructions should work for FreePBX/Asterisk –
When setting up your ‘SIP trunk’ in FreePBX under ‘PEER DETAILS’ you want to put the line –
“context=custom-get-did-from-sip”
then you need to edit the file /etc/asterisk/extensions_custom.conf and add the following lines –
|
Q:
Drag and drop in jquery
I didn't get the id of dropped div on dropping on another div
i get the id_droppable i but didn't get the id_dropped div
The alert id_dropped give undefined as result
Please help me verify my code and correct my error.
$(".full-circle").droppable({
accept: ".unseated_guest",
drop: function(event, ui) {
var id_droppable = this.id;
alert(id_droppable);
var id_dropped = ui.id;
alert(id_dropped);
var name=document.getElementById("div_name_0").value;
$(this).css("background-color","red");
$(this).append(ui.draggable);
//$(this).draggable('disable');
}
});
A:
The ui parameter does not have an id attribute, as it is a reference to the element being drug. You need to get the id like ui.draggable.attr('id'), or whatever method you prefer to get the id of an element.
$(".full-circle").droppable({
accept: ".unseated_guest",
drop: function(event, ui) {
//Stuff above
var id_dropped = ui.draggable.attr('id');
alert(id_dropped);
//Stuff below
}
});
|
South Wayne Historic District
South Wayne Historic District may refer to:
South Wayne Historic District (Fort Wayne, Indiana), listed on the National Register of Historic Places in Allen County, Indiana
South Wayne Historic District (Wayne, Pennsylvania), listed on the National Register of Historic Places in Delaware County, Pennsylvania
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Managing hepatitis B coinfection in HIV-infected patients.
Since viral hepatitis is one of the most common causes of morbidity and mortality in HIV, it is critical to recognize and treat these patients appropriately. Hepatitis B infection is particularly difficult to manage as it changes with shifts in immune status. Inactive infection may flare up with restoration of CD4 cell count. In addition, many drugs used to treat HIV are also active against hepatitis B. Thus, patients may require therapy for both diseases or only for hepatitis B. The practicing physician must be aware of which drug to use with antiretrovirals and which can be used for hepatitis B alone. Current therapies for HIV that have hepatitis B activity include lamivudine, emtricitabine, and tenofovir. Therapies for hepatitis B without HIV activity are adefovir and entecavir. The major advances in the past year include emerging data on epidemiology, occult infection, genotypes, and newer therapies. Long-term management of hepatitis B includes monitoring for hepatocellular carcinoma. Two recent consensus conferences have provided excellent reviews of management of coinfection .
|
/* Generated by RuntimeBrowser
Image: /System/Library/PrivateFrameworks/AppleServiceToolkit.framework/AppleServiceToolkit
*/
@interface ASTMaterializedConnectionManager : NSObject <ASTConnectionManager, ASTConnectionStatusDelegate> {
<ASTConnectionManagerDelegate> * _delegate;
ASTIdentity * _identity;
ASTNetworking * _networking;
NSString * _sessionId;
}
@property (readonly, copy) NSString *debugDescription;
@property (nonatomic) <ASTConnectionManagerDelegate> *delegate;
@property (readonly, copy) NSString *description;
@property (readonly) unsigned long long hash;
@property (nonatomic, retain) ASTIdentity *identity;
@property (nonatomic, retain) ASTNetworking *networking;
@property (nonatomic, retain) NSString *sessionId;
@property (readonly) Class superclass;
- (void).cxx_destruct;
- (void)cancelAllTestResults;
- (void)connection:(id)arg1 connectionStateChanged:(long long)arg2;
- (void)connection:(id)arg1 didSendBodyData:(long long)arg2 totalBytesSent:(long long)arg3 totalBytesExpected:(long long)arg4;
- (void)dealloc;
- (id)delegate;
- (void)downloadAsset:(id)arg1 destinationFileHandle:(id)arg2 allowsCellularAccess:(bool)arg3 completion:(id /* block */)arg4;
- (id)identity;
- (id)init;
- (id)initWithSOCKSProxyServer:(id)arg1 port:(id)arg2;
- (id)networking;
- (bool)postAuthInfo:(id)arg1 allowsCellularAccess:(bool)arg2;
- (id)postEnrollAllowingCellularAccess:(bool)arg1;
- (bool)postProfile:(id)arg1 allowsCellularAccess:(bool)arg2;
- (id)postRequest:(id)arg1 allowsCellularAccess:(bool)arg2;
- (void)postSealableFile:(id)arg1 fileSequence:(id)arg2 totalFiles:(id)arg3 testId:(id)arg4 dataId:(id)arg5 allowsCellularAccess:(bool)arg6 completion:(id /* block */)arg7;
- (void)postSessionExistsForIdentities:(id)arg1 ticket:(id)arg2 timeout:(double)arg3 allowsCellularAccess:(bool)arg4 completion:(id /* block */)arg5;
- (void)postTestResult:(id)arg1 allowsCellularAccess:(bool)arg2 completion:(id /* block */)arg3;
- (id)sessionId;
- (void)setDelegate:(id)arg1;
- (void)setIdentity:(id)arg1;
- (void)setNetworking:(id)arg1;
- (void)setSessionId:(id)arg1;
@end
|
Dr. Stranger” Park Hae Jin And Kang So Ra’s Hearts Do Not Align
People who have loved realize how hard it is to have a mutual love. This is true for those in a one sided love and that which is mutual. He has the background and the looks but because he couldn’t love on his own, he made viewers cry.
In the drama, Han Jae Joon plays the role of a person whose father dies in a medical malpractice incident and is determined to ruin Myungwoo University Hospital. Despite the fact that he has a fancy background of being the assistant professor of Harvard University, he becomes the head of Myungwoo University and commits to a love with Oh Soo Hyun.
This was all a process to gain revenge and even from the very beginning of the drama, Han Jae Joon looked at Oh Soo Hyun in a cold way. He looked sincere when he was in front of her but Oh Soo Hyun couldn’t see his eyes, he was in a state where he would show his own ambitions.
Nonetheless, his heart was lost to Oh Soo Hyun after a while. He said that it wasn’t love but in the end the princess was more than just a tool for the destruction of the castle.
Jong Suk that was born in South Korea but raised in North Korea and his conflict against the most elite doctor of Korea, Park Hae Jin. The two of them face the greatest conspiracy in a medical drama and fusion drama. It is broadcast every Monday and Tuesday at 10PM.
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Heath®
Made with a classic candy bar favorite, the Heath Bar! Delicious bits of milk chocolate covered English Toffee are mixed throughout and sprinkled on top of a delicious, hand-dipped vanilla Milkshake for plenty of craveable Heath Bar flavor.
|
<?php
namespace Guzzle\Plugin\Cache;
use Guzzle\Common\Exception\InvalidArgumentException;
use Guzzle\Http\Message\RequestInterface;
/**
* Determines a request's cache key using a callback
*/
class CallbackCacheKeyProvider implements CacheKeyProviderInterface
{
/**
* @var \Closure|array|mixed Callable method
*/
protected $callback;
/**
* @param \Closure|array|mixed $callback Callable method to invoke
* @throws InvalidArgumentException
*/
public function __construct($callback)
{
if (!is_callable($callback)) {
throw new InvalidArgumentException('Method must be callable');
}
$this->callback = $callback;
}
/**
* {@inheritdoc}
*/
public function getCacheKey(RequestInterface $request)
{
return call_user_func($this->callback, $request);
}
}
|
-ase
The suffix -ase is used in biochemistry to form names of enzymes. The most common way to name enzymes is to add this suffix onto the end of the substrate, e.g. an enzyme that breaks down peroxides may be called peroxidase; the enzyme that produces telomeres is called telomerase. Sometimes enzymes are named for the function they perform, rather than substrate, e.g. the enzyme that polymerizes (assembles) DNA into strands is called polymerase; see also reverse transcriptase.
The commonly used -ase suffix for naming enzymes was derived from the name diastase.
See also
Amylase
DNA polymerase
Category:Chemistry suffixes
Category:Biological nomenclature
Category:Greek suffixes
|
Directory of leisure activities
Activity is intense along the coast, rivers and lakes. Catamarans, sailing dinghies, surfboard, surfing, canoeing, rowing ... The directory of boating and leisure activities provided by Boating in Brittany is here to help you. Look up the sailing club’s details and savour the pleasures of navigation.
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The present invention is directed generally to telephony devices, and more particular, to telephony devices having integrated messaging capabilities.
As the telecommunications industry has grown, the number and different types of telephony devices has also dramatically increased. The use of telephony devices in mobile and cordless environments has also increased accordingly. There has also been an increased need and interest in providing reliable and easy to use peripheral devices such as answering machines, caller ID boxes, and the like.
Digital answering machines have gained wide spread use by the telecommunications consumers. A typical digital answering machine is formed as a stand alone device which is coupled between a telephone and the subscriber line of the telephone in order to intercept and answer an incoming call under predefined conditions. The answering machine also provides the capability of storing messages from the calling party for later retrieval.
Various approaches have been taken to integrate the functionality of an answering machine within a telephone. For example, the basic components of the digital answering machine have been incorporated into a telephone. Such systems typically include a digital voice memory for storing messages, including broadcast messages and received messages, and a digital signal processor (DSP) dedicated to answering machine functions such as compression of the messages, storage and retrieval. Another approach for integrating answering machine functions within an existing telephone is to provide an answering service remote from the telephone. This type of service routes unanswered calls to the remote answering service where messages are stored for access over the subscriber line.
As the telecommunications industry continues to grow, there remains an interest in providing increased accessibility to the various telephony functions including answering functions. It is also desirable, however, to reduce the overall costs of the various telephony devices. Thus, there is generally a tension between a desire to provide added functionality while meeting the demands of lower costs.
Generally, the present invention relates to communication devices having integrated messaging capabilities. In one particular embodiment, a communication device is provided which operates in a communication mode and a message mode. The communication device includes a speaker, a receiver provided to receive signals of a call received from a calling party and a memory arrangement for storing messages. A processor is coupled to the memory arrangement and is configured to code and decode signals in accordance with a cordless communication compression scheme used for cordless communication when in the communication mode. The processor is further configured to code signals received from the calling party, using the wireless communication compression scheme, for storage in the memory arrangement as a message when in the message mode.
In accordance with another embodiment of the invention, a cordless telephone system having message recording capabilities is provided. The cordless phone includes a base station coupled to a switched telephone network. The base station includes a base station processing unit configured to receive signals from the switched telephone network and to code and decode the signals in accordance with a wireless transmission compression scheme. The base station further includes a transmitter/receiver coupled to the processing unit to transmit/receive coded signals. The cordless phone further includes a handset having a transmitter/receiver configured to transmit/receive coded signals for wireless communication with the base station, and a handset processing unit, coupled to the transmitter/receiver, configured to code and decode signals transmitted to and received from the base station. A memory arrangement is provided within the base station or the handset and is coupled respectively to either the base station processing unit or the handset processing unit. The memory arrangement is used to store messages which are coded by the respective one of the base station processing unit and the handset processing unit using the wireless transmission compression scheme.
One embodiment of the invention provides messaging functions within a cordless phone system. In operation, the base station receives a call from a calling party. The cordless phone retrieves a broadcast message from a memory arrangement of the cordless phone in response to initiation of a message mode. The broadcast message is transmitted from the base station to the calling party. A message from the calling party is received at the base station and coded using a cordless transmission compression scheme used for cordless communication between the base station and the handset. The coded message from the calling party is stored in the memory arrangement of the cordless phone.
In one particular embodiment, data transmitted between the base station and the handset are coded using adaptive differential pulse code modulation (ADPCM). In a further embodiment, the messages stored in the memory arrangement are also coded using ADPCM.
The above summary of the present invention is not intended to describe each illustrated embodiment or every implementation of the present invention. The figures and the detailed description which follow more particularly exemplify these embodiments.
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[A ruptured mycotic aneurysm of the femoral artery due to Salmonella typhimurium].
Mycotic aneurysms of the femoral artery is rare. We report a new case with a mycotic aneurysm of the femoral artery by "Salmonella typhimurium". The surgical operation was performed as surgical emergence for ruptured aneurysm. We did not know the aneurysm infection origin. The treatment of lesions was resection and femoro-femoral bypass with PTFE. The microbiological examination discovered infection material. A posterior bypass infection required a exeresis bypass and new revascularization with iliofemoral saphenous vein bypass by obturator foramen, and antibiotic treatment prolonged.
|
Q:
get images from directory and ad to ul
I'm using a responsive pattern from Brad Frost's library to create an image grid (beta version here: http://yogeshsimpson.com/fry). I want to have three folders of images for the three portfolio categories that my client can just drop images into.
From there I think php is the right tool to get all the images from a folder, wrap in li and a tags and have them added to the ul. So on the homepage you see images from all three directories, and on the "lighting" page for example, you see only images from that directory, etc.
Again I'm assuming this is fairly easy to do with php, but it's a bit beyond my grasp. Any help would be appreciated. Much thanks.
A:
Something like this will work, run it from within the folder you wish to list the files.
<?php
if ($handle = opendir('.')) {
while (false !== ($file = readdir($handle)))
{
if ($file != "." && $file != "..")
{
$thelist .= '<li><a href="'.$file.'">'.$file.'</a>' . "<br>";
}
}
closedir($handle);
}
?>
<P>List of files:</p>
<P><?=$thelist?></p>
Or:
<?php
// if running from your root and wish to list files from 'images' sub-folder
// use $dir = 'images';
$dir = '.'; // The directory containing the files.
// *.* will list all files. You can use *.jpg to list just JPG files, etc.
$ext = '*.*'; // will list ALL files
?>
<ul> <?php foreach (glob($dir . '/*' . $ext) as $file) { ?>
<li><a href="<?php echo $dir . "/" . $file ?>"><?php echo basename($file); ?></a></li>
<?php } ?> </ul>
|
Date: {{.Date}}
From: MAILER-DAEMON@{{.Me}}
To: {{.RcptTo}}
Subject: failure notice
Hi. This is the tmail deliverd program at {{.Me}}
I'm afraid I wasn't able to deliver your message to the
following addresses. This is a permanent error; I've given up.
Sorry it didn't work out.
<{{.RcptTo}}>:
{{.ErrMsg}}
--- Below this line is a copy of the message.
{{.BouncedMail}}
|
Glutathione localization by a novel o-phthalaldehyde histofluorescence method.
Glutathione in tissues forms an intense fluorophore with a solution of o-phthalaldehyde at room temperature. We have studied the loss of glutathione from tissue sections and find that it is not measurable from thick sections. The fluorescence spectra of the induced fluorophore between glutathione and o-phthalaldehyde are identical in model and tissue sections, while depletion of hepatic glutathione by diethyl maleate produces a comparable fall in fluorescence measured biochemically or histochemically. This simple method is specific as interfering substances, such as spermine and spermidine, produce very weak fluorescence under the conditions employed.
|
extern NSString * const SERVICE_RESPONSE_ID;
extern NSString * const SERVICE_RESPONSE_UUID;
extern NSString * const SERVICE_RESPONSE_DEVICE_ID;
extern NSString * const SERVICE_RESPONSE_ID_PRIMARY;
|
Quick and Easy Pate Recipe
Even people who say they don't like liver love this easy spread. It is always a hit at parties. It can be made a couple of days ahead, which is a big plus during the holiday season. Recipe from the good folks at Bacardi Rum.
|
Immunochromatography can be utilized to perform tests of various diseases simply and easily.
Because an analyte in a specimen is usually a slightly-existing substance, such as an influenza virus, HBs antigen or the like, there are demands for enhancement of sensitivity of immunochromatographic tests. Also, there are demands for a test device that permits rapid detection of an analyte in a specimen.
Conventional test devices, however, have a problem that a long time is required for the elution of a labeling substance from a label holding member and thus for obtaining test results.
|
Virginia Department of Elections
The Virginia Department of Elections is an agency that administers elections in Virginia. Its duties include maintaining a voter registration system.
The Department is led by a three-member body, the State Board of Elections. State law provides, "The State Board, through the Department of Elections, shall supervise and coordinate the work of the county and city electoral boards and of the registrars to obtain uniformity in their practices and proceedings and legality and purity in all elections." The Department's current commissioner is Christopher E. "Chris" Piper.
References
External link
Official site
Category:Virginia elections
Category:Election commissions in the United States
|
using System;
namespace Zio
{
/// <summary>
/// The <see cref="EventArgs"/> base class for file and directory events. Used for
/// <see cref="WatcherChangeTypes.Created"/>, <see cref="WatcherChangeTypes.Deleted"/>,
/// and <see cref="WatcherChangeTypes.Changed"/>.
/// </summary>
/// <inheritdoc />
public class FileChangedEventArgs : EventArgs
{
/// <summary>
/// The type of change that occurred.
/// </summary>
public WatcherChangeTypes ChangeType { get; }
/// <summary>
/// The filesystem originating this change.
/// </summary>
public IFileSystem FileSystem { get; }
/// <summary>
/// Absolute path to the file or directory.
/// </summary>
public UPath FullPath { get; }
/// <summary>
/// Name of the file or directory.
/// </summary>
public string Name { get; }
public FileChangedEventArgs(IFileSystem fileSystem, WatcherChangeTypes changeType, UPath fullPath)
{
if (fileSystem == null) throw new ArgumentNullException(nameof(fileSystem));
fullPath.AssertNotNull(nameof(fullPath));
fullPath.AssertAbsolute(nameof(fullPath));
FileSystem = fileSystem;
ChangeType = changeType;
FullPath = fullPath;
Name = fullPath.GetName();
}
}
}
|
Q:
How to use other application.conf in tests than in prod code?
im trying to test PersistentActor with scalatest but I dont know how to point test code to use something like application-test.conf instead application.conf ( I want to change leveldb store for events to in memory store ). Is there any convenient way to do this?
A:
You could define another application.conf in your test resources:
src/test/resources/application.conf
This way, you can have test related configuration that will be used by default in your tests.
If you still require multiple configuration settings among your tests, you can always have more than one configuration file in the test resources and explicitly use the one you need:
class PersistentActorSpec extends TestKit(ActorSystem("test-system", ConfigFactory.load("application-test")))
|
module Intrigue
module Core
module Model
class Issue < Sequel::Model
plugin :validation_helpers
plugin :timestamps
many_to_one :project
many_to_one :task_result
many_to_one :entity
self.raise_on_save_failure = false
def self.scope_by_project(project_name)
where(:project => Intrigue::Core::Model::Project.first(:name => project_name))
end
def validate
super
validates_unique([:entity_id, :name, :project_id, :source], allow_nil: true)
end
def uuid
project_name = self.project.name if self.project
project_name = "missing_project" unless project_name
source = source if source
source = 'intrigue' unless source
out = "#{project_name}##{self.name}#{source}##{entity.uuid}"
Digest::SHA2.hexdigest(out)
end
def to_s
"#{name} on #{entity.type} #{entity.name}"
end
def to_v1_api_hash(full=false)
if full
export_hash
else
{
:type => name,
:name => name,
:category => category,
:severity => severity,
:status => status,
:scoped => scoped,
:source => source || "intrigue",
:pretty_name => details["pretty_name"],
:entity_type => entity.type,
:entity_name => entity.name
}
end
end
###
### Export!
###
def export_hash
{
:type => name,
:name => name,
:category => category,
:severity => severity,
:status => status,
:scoped => scoped,
:source => source || "intrigue",
:description => description,
:pretty_name => details["pretty_name"],
:identifiers => details["identifiers"],
:remediation => details["remediation"],
:references => details["references"],
:entity_type => entity.type,
:entity_name => entity.name,
:entity_aliases => entity.aliases.map{|a| {"type" => a.type, "name" => a.name} },
:entity_alias_group_id => entity.alias_group_id,
:details => details,
:task_result => "#{task_result.name if task_result}",
:task_result_entity_name => "#{task_result.base_entity.name if task_result}",
:task_result_entity_type => "#{task_result.base_entity.type if task_result}"
}
end
def export_csv
"#{type}, #{name}, #{severity}, #{status}, #{description.gsub(",",";")}, #{entity.type}, #{entity.name}, #{entity.alias_group_id}"
end
def export_json
export_hash.merge("generated_at" => "#{Time.now.utc}").to_json
end
end
end
end
end
|
Triangle Shaped Dining Tables
For a true non-conformist triangle shaped dining tables may hold a special appeal. In this case, “four is a crowd” as opposed to the old axiom “three is a crowd”. It definitely makes a different statement in a dining room as opposed to more traditional shapes of rectangular, round or square. This product is called Globe and comes from Domitalia Design. From the second picture it does look like you can squeeze in a fourth chair if needed.
|
describe('nodezip', function() {
beforeEach(function() {
this.nodezip = require('..')();
});
describe('when initialized', function() {
it('should load JSZip in this.nodezip', function() {
expect(this.nodezip.options).not.toBeNull();
});
it('should declare JSZip', function() {
expect(JSZip).not.toBeNull();
});
});
describe('when archiving a dummy file', function() {
beforeEach(function() {
this.fs = require("fs");
this.dummyFile = this.nodezip.file('test.file', 'hello there');
this.dummyFileData = this.dummyFile.generate({base64:false,compression:'DEFLATE'});
});
it('should contain valid data', function() {
expect(this.dummyFileData).not.toBeNull();
expect(this.dummyFileData).toMatch(/^PK/);
expect(this.dummyFileData).toMatch(/test.file/);
});
it('should be able to write file', function() {
this.fs.writeFileSync('test.zip', this.dummyFileData, 'binary');
expect(this.fs.lstatSync('test.zip')).not.toBeNull()
});
it('should be able to deflate file', function() {
this.dummyFileData = this.fs.readFileSync('test.zip', 'binary');
this.dummyFile = new JSZip(this.dummyFileData, {base64: false, checkCRC32: true});
expect(this.dummyFile.files['test.file'].asText()).toEqual("hello there");
this.fs.unlink('test.zip');
});
});
});
|
Actually, that's not surprising. They have CDNs (data servers) all over the world which keep local copies of video/music/apps so that they don't need to continuously clog up the pipes in the middle pushing the same data over and over again. The upshot is that if a major line goes down you can still access your content.
I'm just going to get all of the irrational comments out of the way before anybody else does:
Steve Jobs is rolling in his urn!
This never would have happened if Steve Jobs were alive!
Really, Apple? Really?! Wow, just... Wow.
Further proof Apple has gone downhill.
Figures, more articles on iOS and nothing about any new Macs coming out.
(Something about how awesome Android is.)
Did I miss anything?
- I don't believe Tim Cook's new products anymore
- 1GB of RAM ain't enough
- This is what you get for having assembly lines in China
- Final proof that the iWatch is going to be released. Today.
- and the most important of all : "Analists predict that service will be restored in the near or far future."
|
The natural beauty of the forest and the wetlands is enhanced by two creeks that wander throughout, as well as numerous ponds and Ohio Valley sand-filled bunkers that await any errant strokes.
Four sets of tee blocks on every hole allow the novice golfer to appreciate the generous landing areas, while challenging the more accomplished player to execute a variety of shots using every club in the bag.
|
Congratulations! Here are the search results for all local florists near me. Scroll to find a florist or easily refine your search results of local florists by category, geography or florist ratings. Click the "Map View" tab so display the results on a map to find the closest florist to me. Enhance your floral experience and look for the “Verified” florist banner on your local flower shop listing.
Ari Garden Flower is a local florist offering same day flower delivery in Bronx, NY. Order flowers online or call to send flowers to Bronx. Leave a rating or review and remember to mention floristopia!
She Loves Me Not Flower Btq is a local florist offering same day flower delivery in Bronx, NY. Order flowers online or call to send flowers to Bronx. Leave a rating or review and remember to mention floristopia!
Pure Elegance Floral is a local florist offering same day flower delivery in Bronx, NY. Order flowers online or call to send flowers to Bronx. Leave a rating or review and remember to mention floristopia!
Rosa's Florist Shop is a local florist offering same day flower delivery in Bronx, NY. Order flowers online or call to send flowers to Bronx. Leave a rating or review and remember to mention floristopia!
|
[Construction of wild-type and mutant SPAST vectors for the study of molecular mechanism of hereditary spastic paraplegia].
To construct wild-type and mutant pEGFP SPAST vectors and to explore the molecular mechanism of hereditary spastic paraplegia. Mutant SPAST vector was constructed using overlap PCR method following construction of wild-type SPAST vector. Wild-type and mutant constructs were transfected to COS7 cells and subcellular localization of spastin was observed. Co-localizations of spastin and microtubule, spastin and mitochondria were viewed by immunofluorescence staining. Wild-type spastin is localized in plasma, and mutant spastin did not change its cellular localization. Wild-type and mutant spastins did not co-localize with microtubules and mitochondria by immunofluorescence analysis. Wild-type and mutant SPAST constructs were successfully generated. Mutant spastin did not change its localization in cells. Spastin does not co-localize with microtubules and mitochondria. This study may facilitate further studies on molecular mechanism of hereditary spastic paraplegia.
|
I’m not exactly sure who introduced me to blood oranges, not clear on where I was, or when it even happened. But I’d like to take a minute and say whoever you are, where ever you are, thank you. I owe ya one (a blood orange, that is).
I love bulking up on citrus this time of year. In the winter months, citrus is at its peak season and is so fresh, juicy, and delicious. It’s probably no coincidence either that these vitamin C-packed, immune-boosting fruits are abundant in the winter when cold and flu season is in full-force.
The moro (blood) orange is one variety not to miss because of its uniqueness in appearance and flavor. Its flesh is deep red, a far cry from its orange friends and family. And that deep red color means it contains a powerful antioxidant – anthocyanin, which protects the body from oxidative damage. It’s also less acidic than navel oranges and sweet enough that you can almost taste a hint of raspberry or strawberry.
I’ve been into roasting fruits lately (ever since my epic roasted balsamic strawberry shortcake last year) and wanted to try roasting blood oranges to see this awesome fruit taken to another level. Roasting caramelized the sugars so it definitely bumped the sweetness up a notch, which made them a perfect addition to morning oatmeal.
I feel like oatmeal gets a bad rep and I’m not sure why exactly. People think it’s boring, bland, the list goes on. But everyone knows that an outfit is only as good as its accessories, right? Jeans and a tee shirt can only go so far unless you pair them with a cute pair of flats and a statement necklace. Same thing with oatmeal. You’ve got to accessorize it to make it beautiful (and delicious).
I also think this could be a perfectly pretty breakfast-in-bed for you and your sweetheart for Valentine’s Day next weekend.
I think I was first introduced to blood oranges when I studied abroad in Florence, Italy, and I’ve loved them ever since! I’ve been really into using them in salads, especially with fennel, this winter!
|
Evidence Accumulation and Flow of Control in a Hierarchical Spatial Reasoning System
K. M. Andress, Avi Kak
Abstract
A fundamental goal of computer vision is the development of systems capable of carrying out scene interpretation while taking into account all the available knowledge. In this article, we focus on how the interpretation task can be aided by the expected scene information (such as map knowledge), which, in most cases, would not be in registration with the perceived scene. The proposed approach is applicable to the interpretation of scenes with three-dimensional structures as long as it is possible to generate the equivalent two-dimensional orthogonal or perspective projections of the structures in the expected scene. The system is implemented as a two-panel, six-level blackboard and uses the Dempster-Shafer formalism to accomplish inexact reasoning in a hierarchical space. Inexact reasoning involves exploiting, at different levels of abstraction, any internal geometric consistencies in the data and between the data and the expected scene. As they are discovered, these consistencies are used to update the system's belief in associating a data element with a particular entity from the expected scene.
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Request an Interview With A Heritage Expert
Thank you for contacting us!
Adam N. Michel focuses on tax policy and the federal budget as a Policy Analyst in the Thomas A. Roe Institute for Economic Policy Studies at The Heritage Foundation. His research focuses on the economics of taxation, international tax competition, and the federal budget.
Michel is published and quoted in outlets such as The New York Times, Wall Street Journal, Politico, US News and World Report, and The Federalist. Prior to joining Heritage he was a Program Manager for the Spending and Budget Initiative at the Mercatus Center at George Mason University, where he worked on a broad range of topics relating to federal fiscal policy. He has also worked as a Research Associate at the Competitive Enterprise Institute.
Michel received his MA in economics from George Mason University in Fairfax, VA and also holds a BA in politics from Whitman College in Walla Walla, WA. He is an alumnus of the Mercatus MA Fellowship program and is currently pursuing his PhD in economics at George Mason University.
Originally from California, Michel enjoys rock climbing, skiing, and cooking in his spare time.
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MODULE_TOPDIR = ../..
PGM = i.gensig
LIBES = $(IMAGERYLIB) $(RASTERLIB) $(GISLIB) $(MATHLIB)
DEPENDENCIES = $(IMAGERYDEP) $(RASTERDEP) $(GISDEP)
include $(MODULE_TOPDIR)/include/Make/Module.make
default: cmd
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Q:
What did Acton mean by saying "absolute power corrupts absolutely"?
John Dalberg-Acton, 1st Baron Acton said that
"[p]ower tends to corrupt, and absolute power corrupts absolutely."
What did he mean by this? How might power compel evil or restrict free will?
A:
NOTE: This answer was given to a previous incarnation of this question. The block quotes I am responding to come from this incarnation. If I have the time I will modify my answer to respond more directly to this version of the question.
When a person is placed in a position of absolute power, is it necessarily true that this power will condemn that person to commit evil acts?
No, it isn't necessarily true, and that isn't a part of the claim Acton is making. Note the use of the word "tends". Many people have defended the possibility of a benevolent dictator. Plato's Republic advances an oligarchy of "Philosopher Kings", which he thought would produce the best society.
In effect, does power restrict free will?
I don't think there is any very interesting connection between these two concepts, if anything it seems to be the opposite. Someone with absolute (unchallengeable) power would be faced with no external compulsions and so (assuming the possibility of free will) would have the best chance at freely acting.
NOTE: The following is a bit of an aside that is only indirectly relevant, but which you may, nevertheless, find interesting.
There is, however, an interesting claim that Socrates makes in Plato's Gorgias:
I say, Polus, that both orators and tyrants have the least power in their cities, as I was saying just now. For they do just about nothing they want to, though they certainly do whatever they see most fit to do. (Gorgias, 466e)
This weird claim has to do with Socrates' denial of akrasia, or weakness of will, where you act against what you believe to be best. Essentially, the claim he makes here is tyrants who commit evil are, in fact, slaves to their stupidity (to put it rather crudely). For, Socrates contends, they are making mistakes in measurement and wrongly considering the evil act to be the best.
This is, in fact, a bit of a caricature of the view, at least it doesn't explain it fully. I just thought it was interesting in connection with your question and presents a view on which "doing whatever you see fit" is not to have great power. It is also a view on which someone with the ability to do whatever they see fit actually does very little that they want to do.
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Mit dem Computer verschmelzen Technikvisionäre planen eine Welt, in der Computer unsere Gedanken lesen. Auch das US-Verteidigungsministerium unterstützt Forschung in diese Richtung.
Heute kommunizieren manche Personen über eine Elektrodenkappe mit dem Computer. (Bild: Alexandra Wey, Keystone)
Der Unternehmer Elon Musk will wieder einmal die Welt retten. Er glaubt, dass intelligente Roboter uns eines Tages überlegen sein werden. Um zu verhindern, dass sie die Weltherrschaft übernähmen, müsse der Mensch über sich selbst hinauswachsen und mit der künstlichen Intelligenz verschmelzen.
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Q:
Matrix Factorization algorithms for Recommender Systems
I need to learn about Matrix Factorization for recommender systems, so I downloaded this paper https://datajobs.com/data-science-repo/Recommender-Systems-[Netflix].pdf but I found it too shallow. It didn't explain the concepts in depth for me. So can you please recommend some good papers/resources to learn about the topic?
I need to learn about them so I can implement a matrix factorization model.
A:
Matrix factorisation is part of Numerical Linear Algebra (NLA). The following are some useful books in NLA and Data Mining / Statistical Learning.
The classic in NLA is Golub & Van Loan's Matrix Computations. Van Loan's webpage lists his books in and links to others.
A modern approach that's great for self-study, is Numerical Linear Algebra by Trefethen & Bau, partially available online on Trefethen's website. Bau was working at Google last I checked.
For a data mining focus, Numerical Linear Algebra and Applications in Data Mining by Lars Elden is available online.
A classic on the statistical side is Elements of Statistical Learning by Hastie, Tibshirani, and Friedman. The authors have graciously made available their entire book online. This requires a fair bit of mathematical background, but the introductions to each topic will be accessible more generally.
A lighter version of the above is Introduction to Statistical Learning with Applications in R, by the same authors plus Daniella Witten. This is also available online by the authors and provides useful R code.
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(function() {
'use strict';
angular.module('journalism_workflow.v1.copy_editor', []);
})();
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Teens are Working Without a Net
Peer and cultural pressure lead to a disconnect
from one’s own beliefs and values.
No information and bad information lead to
uninformed decision making.
The absence of healthy relationship frameworks
lead to poor relationship choices.
Silence and shame lead survivors of sexual abuse
and violence to suffer alone.
That’s where we come in.
Who We Are
Talk is an organization of young people, by young people, for young people, working to make Sex Ed better for the next generation. Talk challenges conventional notions of Sex Ed, how it should be taught, and what it means to be “at risk” for making poor relationship and sexual health decisions.
Our Mission
Talk’s Mission is to create a national corps of recent college graduates dedicated to empowering teens to make informed, responsible choices about their relationships and sexual health – and empowering parents to convey their beliefs and values to guide teens’ decision-making.
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Sorry but ... Something is wrong.Status Code: 500PUOE1Wm9cuU2ptteiEGOKZo7ofCajFuvb5fewYJGlP+mXIP3+y2FIh0USnoElz4cPe+YF6vQj+lNi6EhPh9d1dmoiU2TckI5iBXbqPc3JF0WcB2GQOoTw2IsPoVf2U8aaQvgh63+Yq680KeKYh5JfLhYCgLYe+YFfEu1WUHWwnyCXWOv58V6q+0ZnSv1zu5zCEYSCEenxB+Tf2TOtyZJ4nkAfLViUvD6KYo05EZ2/DdL5qroeE9V7XrLXbQ9ncKMrCTbDxO9B7W0QhBX72lbm7Ywp/IB5RWxELg60runKS78tvSBjLWnJekQ/YK+rvUUX0xu3awtY03FPoYHx5i23155/MI4H6vgP2bIBfQRKQ+Sb1jaXPio+mi8MfymfPTiHsZ4q4kSc+ZXEwFyyVgizxKGnqhUFrLnzQG5kePwkJNC4rVaP7NhURe+n0HG0n4ZUGbA4Tg9yiygQm6a2+Jigg==Instructions: Please don't send a screenshot but copy the full error trace if you want to report this error to our team
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Yes, the Democrats oppose sanctions, but they still agree that the US needs to oust Nicolás Maduro. The Republicans go even further and put the military option on the table. So the only position that we can have is to oppose the US effort to topple this government, to oppose this threat of war, and to demand an immediate end of sanctions. It's not our place to be pontificating about holding 'free and fair elections' if the objective conditions render them impossible.
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Influence of carrier surface fines on dry powder inhalation formulations.
The performance of carrier-based dry powder inhalation formulations strongly depends on particle interactions between the drug and the carrier. Among other factors like particle size and shape, surface properties of the interacting partners play a decisive role. This study aims at investigating the effect of carrier surface characteristics on the in vitro deposition of ordered mixtures containing salbutamol sulfate as a drug and lactose and mannitol as model carrier compounds. The wet decantation method was used to remove the carrier fines adhered to the carrier surface and to obtain smoother carrier surfaces. In vitro deposition was investigated using the Next Generation Impactor. In comparison to the formulations containing untreated carriers, the removal of carrier fines by wet decantation leads to a reduced in vitro deposition. This is possibly caused by an increase in the surface smoothness and an increase in the number of high energetic spots.
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A bitter pill? German bishops take a bold step in allowing emergency contraception
As the Catholic bishops in the United States continue to fight for their religious liberty by arguing that opposition to all artificial contraception is a deeply held belief of the Catholic faith, the German Catholic bishops have gone in the opposite direction, announcing they will now allow Catholic hospitals to give the "morning after" pill to rape victims.
Archbishop Robert Zollitsch said a four-day meeting of German bishops in the western town of Trier had "confirmed that women who have been victims of rape will get the proper human, medical, psychological and pastoral care".
"That can include medication with a 'morning-after pill' as long as this has a prophylactic and not an abortive effect," he said in a statement. "Medical and pharmaceutical methods that induce the death of an embryo may still not be used."
This means the German bishops are drawing a distinction between contraceptives that prevent pregnancy and those that might halt the development of an already fertilized egg. That distinction maintains the church's teaching that human life begins at the moment of conception, but is a departure from the church's belief that any artificial means of preventing pregnancy is immoral.
The German bishops' decision stems from a case in which a woman was denied treatment at a German Catholic hospital after being drugged at a party and raped. The bishops had to wade through some complex questions here, such as whether taking artificial steps to prevent pregnancy--which some see as God's will, even in rape cases--is ever morally justified. Their conclusion that it is an acknowledgement of the fact that contraception may not be as much of a black and white issue as some Catholics would believe.
I don't expect the German bishops' decision to be the tidal wave that changes the church's stance on contraception. But it certainly is a ripple in the ocean that will get people talking. I'm sure that many Catholics would like to see the issue brought up for a serious debate in the global church, even if that discussion doesn't seem to fit the agenda of the U.S. bishops.
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Natural Gas Drilling Technique Gets Congressional Attention
Wyoming – Wyoming officials are fighting to keep Washington from regulating natural gas drilling. They say the state is perfectly capable of taking care of its own natural resources. Critics say drilling companies are polluting water supplies. Eric Niiler has more.
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Q:
Installing Windows shell extension DLL with Inno Setup installer
I'm developing a shell extension DLL. I want to install it using Inno Setup installer. I seen installers that ask, if I wanted to install shell extension with the program, I would like something similar using Inno Setup installer. How do I go about doing this?
If not, would you be able to direct me to the right path. I been searching for days about any info about this.
A:
The shell extension is just a DLL with a COM class. So just deploy it and register it using the regserver flag:
[Files]
Source: "myext.dll"; DestDir: "{app}"; Flags: regserver
See also Register Explorer COM extension only if specific task was selected.
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Mario & Luigi Bowser’s Inside Story
A single player action RPG (Role-playing Game), Mario & Luigi: Bowser's Inside Story takes players on the DS literally into the belly of the beast - that beast being Bowser. Set within an off-the-wall storyline that turns the world of Nintendo on its ear and featuring the ability to toggle between playing as the team of Mario and Luigi, and playing as Bowser himself, this third installment of the Mario & Luigi franchise is n (more...)
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Q:
How are dates typically handled with testing?
I am writing an app at the moment that has some pretty extensive business logic based around dates. I have several hundred thousand records to test and testers who want to see how those records are handled, which has worked well so far, however, some edge cases are difficult to replicate. The reason is that most of the logic is related to today's date, in one way or another. What is the best way to handle this with both unit testing and for traditional testing? The only way I can really think of is allowing for today's date to be faked and fixed.
A:
Faking and fixing the date are the right way to do it. It can actually morph into a useful feature -- how many times have you wanted to be able to run a piece of logic using past data?
A:
You can use mocks (dependency injection) to return "today" date to be whatever you want it to be. This will allow you to test problem dates and make sure that new additions will not break the old code.
There are plenty of mocking framework around and I am sure $language that you are using has at least a couple of good ones.
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--bail
--reporter spec
--timeout 20s
|
Q:
Reverse a string and get an error
The error is
The best overloaded method match for 'string.String(char[])' has some invalid arguments
My code:
string reverseValue = new string(
value.Select((c, index) => new { c, index })
.OrderByDescending(x => x.index).ToArray());
A:
char[] chars = value.ToCharArray();
Array.Reverse(chars);
new String(chars);
Or (somewhat slower)
new String(value.Reverse().ToArray());
Note that this won't handle UTF32 surrogate pairs, nor combining characters.
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<?php
namespace Kanboard\Subscriber;
use Symfony\Component\EventDispatcher\EventSubscriberInterface;
use Kanboard\Core\Security\AuthenticationManager;
use Kanboard\Core\Session\SessionManager;
use Kanboard\Event\AuthSuccessEvent;
use Kanboard\Event\AuthFailureEvent;
/**
* Authentication Subscriber
*
* @package subscriber
* @author Frederic Guillot
*/
class AuthSubscriber extends BaseSubscriber implements EventSubscriberInterface
{
/**
* Get event listeners
*
* @static
* @access public
* @return array
*/
public static function getSubscribedEvents()
{
return array(
AuthenticationManager::EVENT_SUCCESS => 'afterLogin',
AuthenticationManager::EVENT_FAILURE => 'onLoginFailure',
SessionManager::EVENT_DESTROY => 'afterLogout',
);
}
/**
* After Login callback
*
* @access public
* @param AuthSuccessEvent $event
*/
public function afterLogin(AuthSuccessEvent $event)
{
$this->logger->debug('Subscriber executed: '.__METHOD__);
$userAgent = $this->request->getUserAgent();
$ipAddress = $this->request->getIpAddress();
$this->userLockingModel->resetFailedLogin($this->userSession->getUsername());
$this->lastLoginModel->create(
$event->getAuthType(),
$this->userSession->getId(),
$ipAddress,
$userAgent
);
if ($event->getAuthType() === 'RememberMe') {
$this->userSession->validatePostAuthentication();
}
if (session_is_true('hasRememberMe')) {
$session = $this->rememberMeSessionModel->create($this->userSession->getId(), $ipAddress, $userAgent);
$this->rememberMeCookie->write($session['token'], $session['sequence'], $session['expiration']);
}
}
/**
* Destroy RememberMe session on logout
*
* @access public
*/
public function afterLogout()
{
$this->logger->debug('Subscriber executed: '.__METHOD__);
$credentials = $this->rememberMeCookie->read();
if ($credentials !== false) {
$session = $this->rememberMeSessionModel->find($credentials['token'], $credentials['sequence']);
if (! empty($session)) {
$this->rememberMeSessionModel->remove($session['id']);
}
$this->rememberMeCookie->remove();
}
}
/**
* Increment failed login counter
*
* @access public
* @param AuthFailureEvent $event
*/
public function onLoginFailure(AuthFailureEvent $event)
{
$this->logger->debug('Subscriber executed: '.__METHOD__);
$username = $event->getUsername();
if (! empty($username)) {
// log login failure in web server log to allow fail2ban usage
error_log('Kanboard: user '.$username.' authentication failure');
$this->userLockingModel->incrementFailedLogin($username);
if ($this->userLockingModel->getFailedLogin($username) > BRUTEFORCE_LOCKDOWN) {
$this->userLockingModel->lock($username, BRUTEFORCE_LOCKDOWN_DURATION);
}
}
else {
// log login failure in web server log to allow fail2ban usage
error_log('Kanboard: user Unknown authentication failure');
}
}
}
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Abstract
A method for investigating the nature of thermally activated relaxations in terms of their cooperative character is tested in both polymer and low molecular weight crystal systems. This approach is based on analysis of the activation entropy in order to describe thermally activated relaxations. The betaine arsenate/phosphate mixed system of low molecular weight crystals was selected for investigation because pure compounds of this system show ferro-/antiferroelectric phase transitions and the mixed crystals undergo different kinds of relaxation processes involving both dipole–dipole and dipole–lattice interactions. The polymer chosen was a side chain liquid-crystalline polysiloxane, which shows the β-relaxation characteristic of disordered systems and amorphous materials. The cooperative versus local character of the relaxations is described in terms of “complex” and “simple” relaxations based on calculations of the activation entropies. The initial assumptions of the theory, as well as the resulting equations, were found to be applicable to the systems studied.
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{
"match": false,
"comment": "Paths do not match",
"expected" : {
"method": "POST",
"path": "/path/to/something",
"query": "",
"headers": {}
},
"actual": {
"method": "POST",
"path": "/path/to/something/else",
"query": "",
"headers": {}
}
}
|
Q:
Why is "Nous sommes" used for days of the week?
I've just been curious about this. Why is it that saying a day of the week, something like "It's monday" uses 'nous'? as in:
Nous sommes lundi.
Am I able to say it another way? is using:
Aujourd'hui c'est lundi. / C'est lundi.
an acceptable format for a day of the week?
Furthermore, if that's the case, can I use
On est lundi.
in less formal contexts?
I just want to know which of these is correct to use, and why it is that 'nous' is used pour les jours de la semaine.
Merci!
A:
Nous sommes lundi is a slightly formal/written way to tell which day of the week it is. One can also say Nous sommes [le] lundi premier septembre.
This French idiom can only be used in the first person plural.
You can't say Je suis lundi or ils sont lundi because the current weekday is expected to be the same for everyone.
The same idiom exists in Spanish: Estamos a lunes and Italian: Siamo [a] lunedì.
In English, while "We are Monday" will sound very foreign, one can say "We are late", "We are on time" or "We are in September" which are close.
Aujourd'hui, c'est lundi or simply c'est lundi are fully acceptable equivalents.
On est lundi is a less formal and more common way to say nous sommes lundi.
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This invention relates to an open wall storage assembly for use with unfinished walls and, in particular, a wall storage assembly for use in a wall region containing a plurality of vertical wall supports.
In present day home construction, large areas of interior walls are left unfinished, typically in the basement and garage areas, although work rooms and laundry areas may be similarly unfinished. The homeowner desirous of utilizing this wall area typically provides shelving affixed to the exposed or internal surface of the vertical supports, thus providing storage which protrudes into the room area. A similar result obtains when closed wall storage assemblies such as cabinetry, are also affixed. Since these areas are frequently located in regions where space is at a premium, for example, the area adjacent customary automobile parking in garage facilities and areas adjacent the location of laundry equipment, the inability of the homeowner to effectively utilize the regions between vertical wall supports results in already crowded areas becoming further confined.
While a variety of different shelving schemes and outwardly expandable cabinetry is available to promote storage in these areas, the homeowner is faced with a loss of room space especially where the cabinetry contains doors. Furthermore, the mounting of these storage assemblies on the relatively narrow face of the vertical support members utilized in house construction frequently requires the use of additional supporting structure underlying the assembly. This type of storage is characterized by the lack of utility of the region located within the wall between the vertical wall supports. In the construction of the typical house, it is common to find horizontal structural supports placed for fire break purposes and occasionally for structural rigidity between adjacent wall supports. If these members are present, the homeowner is reluctant to disturb them from both a structural and a fire retardant point of view. If these horizontal members are not present, the region between vertical supports and behind any such storage apparatus mounted on the narrow surfaces of the wall supports can act as a flue in the eventuality of fire along the base of the wall.
Accordingly, it is a primary object of the present invention to provide an open wall storage assembly for use with unfinished walls which is readily installable by the homeowner and effectively utilizes the region between adjacent vertical wall supports heretofore ignored in the construction of storage means. Furthermore, the invention is characterized by a large area integral member which is utilized in surrounding engagement with adjacent vertical members and has flange members on the opposing vertical ends for affixation to the vertical wall supports. In the present invention, the individual installer can place the transverse shelving members at locations to fit his particular needs. Thus, the invention is located in heretofore unused areas in the support wall so as not to reduce the usable regions within the building.
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import itertools
from ..lang import sig
from ..lang import H
from ..lang import t
from ..lang import L
from ..lang import build_instance
from ..lang import is_builtin
from ..lang import List
from ..lang import instance
from ..Data.Functor import fmap
from Applicative import Applicative
class Monad(Applicative):
"""
The Monad class defines the basic operations over a monad, a concept from a
branch of mathematics known as category theory. From the perspective of a
Haskell programmer, however, it is best to think of a monad as an abstract
datatype of actions.
Dependencies:
Functor, Applicative
Attributes:
bind, __rshift__
Minimal complete definition:
bind
"""
@classmethod
def make_instance(typeclass, cls, bind):
bind = bind ** (H[(Monad, "m")]/ t("m", "a") >> (H/ "a" >> t("m", "b"))
>> t("m", "b"))
if not is_builtin(cls):
def bind_wrap(s, o):
return Monad[s].bind(s, o)
cls.__rshift__ = bind_wrap
build_instance(Monad, cls, {"bind":bind})
return
@sig(H[(Monad, "m")]/ t("m", "a") >> (H/ "a" >> t("m", "b")) >> t("m", "b"))
def bind(m, fn):
"""
bind :: Monad m => m a -> (a -> m b) -> m b
Monadic bind.
"""
return Monad[m].bind(m, fn)
@sig(H[(Monad, "m")]/ t("m", t("m", "a")) >> t("m", "a"))
def join(m):
"""
join :: Monad m => m (m a) -> m a
The join function is the conventional monad join operator. It is used to
remove one level of monadic structure, projecting its bound argument into
the outer level.
"""
__id = (lambda x: x) ** (H/ "a" >> "a")
return bind(m, __id)
@sig(H[(Monad, "m")]/ (H/ "a" >> "r") >> t("m", "a") >> t("m", "r"))
def liftM(fn, m):
"""
liftM :: Monad m => (a1 -> r) -> m a1 -> m r
Promote a function to a monad.
"""
return fmap(fn, m)
instance(Monad, List).where(
bind = lambda x, fn: L[itertools.chain.from_iterable(fmap(fn, x))]
)
|
Controlling the position of functional groups at the liquid/solid interface: impact of molecular symmetry and chirality.
With the aim of controlling the position of functional groups in a substrate-supported monolayer, a new family of functionalized linear alkyl chains was designed and synthesized, aided by molecular mechanics and dynamics simulations of its two-dimensional self-assembly on graphite. The self-assembly of these amino functionalized diamides at the liquid/solid interface was investigated with scanning tunneling microscopy. Intermolecular hydrogen-bonding interactions involving amides, combined with the effect of molecular symmetry and chirality, were found to guide the self-assembly. Control of the relative position and orientation of the amine groups was achieved, in the case of enantiopure compounds. Interestingly, racemates led to both racemic conglomerate and solid solution formation, with a concomitant loss of positional and orientational control of the amino groups as a result.
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Howard reveals black and white love
In a revealing interview, far removed from plastic Geordies like Carrick, Charlton, Bruce and Robson (see the common Manchester United denominator...) Steve Howard has talked ahead of his visit to SJP on Monday with Leicester about his love for Newcastle. Howard follows Brian Laws and Lee Clark in recent games as boyhood fans returning to Gallowgate and said:
'I played there (at SJP) when I was with Derby when we were in the Premier League and it was an amazing experience. My whole family was there and it was a very special day for all of us. I had two main ambitions and I fulfilled them both, to play at Wembley, which I did with Derby in the play-off final, and to play at St James' Park.
All my family are born and bred in Newcastle in the Byker area and they are all mad keen Newcastle fans. I had a season ticket for a couple of years but I eventually had to give it up when I started playing on Saturdays. My dad took me to my first game when I was probably about eight years-old. I don't remember much about it except I was stood in the Gallowgate End of the ground and the atmosphere was amazing.
My hero in those days was Peter Beardsley and then later on it was Alan Shearer. They are legends. Beardsley had amazing skills. He could produce something out of nothing. He had this little shimmy and you knew what was coming but the defenders still couldn't stop him. I was lucky enough to play with him at Hartlepool and he was an amazing professional. I grew up hearing all the stories about the Newcastle number nines and of Super Mac who was my dad's favourite player. My dad used to say he was a proper centre forward who could score from anywhere and could beat defenders up.
The supporters are the most passionate I have ever experienced. They turn up week in, week out and they live and die for their football. That is all they talk about in Newcastle. Everywhere you go the talk is of football and Newcastle.
They really love the game that much. I should go back more often than I do because I always enjoy going back up there. I was devastated when they went down last season. For a club like Newcastle to go down just proved you can't take anything for granted in football. Just because you are a big club like Newcastle doesn't mean you can drop your standards.
I really felt for the fans who buy their tickets every week. The one hope I have is that they will sort out their problems and bounce back stronger than ever. The potential is massive at the club and I believe one day they will fulfil that potential. I think they should appoint Shearer as manager. He is the man to take the club forward and get them back into the Premier League. He will sort it all out.'
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Sewage sludge deriving from biofiltrationof municipal waste abound in soil processed organic substances and mineral fertilization components which may be used for fertil-ization of energy willow plantations. In the article the potential of natural utilization of sewage sludge and the patented device for injection dosage of sludge has been pre-sented. The device enables putting into soil mineral and organic fertilizers with loose consistency and their immediate covering by soil in order to reduce unpleasant smell and limit loss of volatile components of fertilizer.
|
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Product Description
A perfect way to personalize your charm collection is with this Swarovski crystal briolette charm in light rose for October birthdays! This dazzling charm is topped with an antique gold clasp and hardware.
|
Thyme
There are few things more comforting than having a real French Onion Soup – slowly cooked, caramelized onions that turn mellow and sweet in a broth laced with white wine and Cognac. And to finish it off – crunchy baked … Readmore +
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Clearwater Lake (Manitoba)
Clearwater Lake is a lake in Manitoba, Canada. It is the main geographical feature of Manitoba's Clearwater Lake Provincial Park, located northeast of The Pas in western Manitoba.
References
Category:Lakes of Manitoba
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Pigmented villonodular synovitis of the temporomandibular joint.
The first case of pigmented villonodular synovitis of the temporomandibular joint in a Chinese patient is reported. The clinicopathological features are described and the presentation as a parotid mass is emphasized. This rare tumour requires a high clinical suspicion for diagnosis. For removal, meticulous dissection of tumour and facial nerve is necessary.
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Theranostic lipid nanoparticles for cancer medicine.
Disease heterogeneity within and between patients necessitates a patient-focused approach to cancer treatment. This exigency forms the basis for the medical practice termed personalized medicine. An emerging, important component of personalized medicine is theranostics. Theranostics describes the co-delivery of therapeutic and imaging agents in a single formulation. Co-delivery enables noninvasive, real-time visualization of drug fate, including drug pharmacokinetic and biodistribution profiles and intratumoral accumulation. These technological advances assist drug development and ultimately may translate to improved treatment planning at the bedside. Nanocarriers are advantageous for theranostics as their size and versatility enables integration of multiple functional components in a single platform. This chapter focuses on recent developments in advanced lipid theranostic nanomedicine from the perspective of the "all-in-one" or the "one-for-all" approach. The design paradigm of "all-in-one" is the most common approach for assembling theranostic lipid nanoparticles, where the advantages of theranostics are achieved by combining multiple components that each possesses a specific singular function for therapeutic activity or imaging contrast. We will review lipoprotein nanoparticles and liposomes as representatives of the "all-in-one" approach. Complementary to the "all-in-one" approach is the emerging paradigm of the "one-for-all" approach where nanoparticle components are intrinsically multifunctional. We will discuss the "one-for-all" approach using porphysomes as a representative. We will further discuss how the concept of "one-for-all" might overcome the regulatory hurdles facing theranostic lipid nanomedicine.
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Critics Are Trashing the Warcraft Movie and Rogue One Keeps Getting Better - Up At Noon Live!
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if(${CURVE} STREQUAL "BN128")
include_directories(ate-pairing/include)
include_directories(xbyak)
add_library(
zm
STATIC
ate-pairing/src/zm.cpp
ate-pairing/src/zm2.cpp
)
endif()
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Hymn/Song Information
Crown Him with many crowns The Lamb
Crown Him with many crowns,
The Lamb upon His throne;
Hark! how the heavenly anthem drowns
All music but its own:
Awake, my soul, and sing
Of Him who died for thee,
And hail Him as thy chosen King
Through all eternity.
Crown Him the Son of God
Before the worlds began;
And ye who tread where He hath trod,
Crown Him the Son of Man,
Who every grief hath known
That wrings the human breast,
And takes and bears them for His own,
That all in Him may rest.
Crown Him the Virgin's Son,
The God incarnate born,
Whose arm those crimson trophies won
Which now His brow adorn;
Fruit of the mystic rose,
As of that rose the stem;
The root whence mercy ever flows,
The Babe of Bethlehem.
Crown Him the Lord of Love.
Behold His hands and side,
Rich wounds, yet visible above,
In beauty glorified.
No angel in the sky
Can fully bear that sight,
But downward bends his wondering eye
At mysteries so bright!
Crown Him the Lord of life,
Who triumphed o'er the grave,
And rose victorious in the strife,
For those He came to save:
His glories now we sing,
Who died and rose on high,
Who died eternal life to bring,
And lives that death may die.
Crown Him the Lord of peace,
Whose power a scepter sways
From pole to pole, that wars may cease,
and all be prayer and praise.
His reign shall know no end,
and round His piercèd feet
Fair flowers of paradise extend
their fragrance ever sweet.
Crown Him the Lord of heaven,
One with the Father known
One with the Spirit through Him given
From yonder glorious throne.
To Thee be endless praise,
For Thou for us hast died;
Be Thou, O Lord, through endless days
Adored and magnified.
Crown Him the Lord of heaven,
Enthroned in worlds above;
Crown Him the King to whom is given
The wondrous name of love:
All hail, Redeemer, hail!
For Thou has died for me;
Thy praise shall never, never fail,
Throughout eternity.
Crown Him the Lord of lords,
who over all doth reign,
Who once on earth, the incarnate Word,
for ransomed sinners slain,
Now lives in realms of light,
where saints with angels sing
Their songs before Him day and night,
their God, Redeemer, King.
Crown Him the Lord of years,
the Potentate of time,
Creator of the rolling spheres,
ineffably sublime.
All hail, Redeemer, hail!
For Thou has died for me;
Thy praise and glory shall not fail
throughout eternity.
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Popular Cities
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: : : Demography is destiny is an oft used title for reports on everything from the Social Security crisis in the developed world, to the slow motion retaking of the southwest US by people of Hispanic heritage.
: : : The Intergenerational implications of demographic change are profound. The economic and social implications of an ageing population point to no immediate, urgent crisis, but to serious problems which, if not faced soon, will be harder to deal with later. By its nature demographic change arrives slowly, but its effects are profound.
: : This short phrase is sometimes credited to French philosopher and mathemetician Auguste Compte. 17th century, I think.
: It's a spin on the older phrase "geography is destiny." Worth considering the merits of each, but the truest maps are the ones that show demographic borders: languages, religions, etc.
It seems I have been under a misapprehension, as I assumed it meant that one's social, economic, geographic, etc position (ie one's demographic status) determined one's 'destiny'.
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Understanding and reducing variability of SOM neighbourhood structure.
The self-organizing map (SOM) is a nonlinear unsupervised method for vector quantization. In the context of classification and data analysis, the SOM technique highlights the neighbourhood structure between clusters. The correspondence between this clustering and the input proximity is called the topology preservation. We present here a stochastic method based on bootstrapping in order to increase the reliability of the induced neighbourhood structure. Considering the property of topology preservation, a local approach of variability (at an individual level) is preferred to a global one. The resulting (robust) map, called R-map, is more stable relatively to the choice of the sampling method and to the learning options of the SOM algorithm (initialization and order of data presentation). The method consists of selecting one map from a group of several solutions resulting from the same self-organizing map algorithm, but obtained with various inputs. The R-map can be thought of as the map, among the group of solutions, corresponding to the most common interpretation of the data set structure. The R-map is then the representative of a given SOM network, and the R-map ability to adjust the data structure indicates the relevance of the chosen network.
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The female contact of current commercial pin and sleeve electrical connectors, in one common form, has two opposing, semi-cylindrical fingers (or "beams" as they are sometimes called). Together, they form an elongated, cylindrical socket or female receptacle for a male connector pin, both fingers being integral with and extending from a common base in cantilever. Thus, each of the fingers extends from a common base, outwardly in a semi-cylinder to a distal end. Together they form a split cylinder--i.e., the socket. The semi-circular distal ends of the two fingers form an inlet opening to the socket through which the pin is placed in making a connection.
A cylindrical sleeve is located around the outer edges of the fingers and it extends from the base of the fingers to a location short of the outermost or distal ends of the fingers. In other words, the outermost ends of the fingers, in the prior art, extend out of the sleeve at the location where they receive the connector pin in mating coupling. The cylindrical sleeve thus limits the outward flexing of the fingers at their base, but it leaves the inlet ends free, where damage can occur.
Typically, connectors of this type have two through five or more poles, each pole being represented by a mating pin of a male connector and a corresponding socket of a female connector. All of the connector elements for both the male and the female connectors are held in place by a plastic body called an insert. An electric cable having a conductive wire for each pole is assembled to each male and female connector, with a wire attached to each connector element; and a covering or sheath of soft insulating plastic is molded to bridge the jacket of the cable to the insert, thereby enclosing and sealing the connections of the electrical wires to the connector elements. Thus, these connectors are frequently referred to in the industry as "molded" connectors.
In connectors of this type, the primary mechanism for limiting the diameter of a pin being inserted is the opening formed in the plastic insert body just beyond the outer-most extension of the fingers. However, the insert body, being formed of a pliable, molded plastic, deforms under force, so that it is not uncommon for a person to attempt to assemble a male connector having oversized pins into a corresponding female connector. This may lead to damage.
Experience has shown there are two problems with the female connector in the prior art structure. It must be realized that molded connectors are typically used in industrial or commercial applications and that they experience rugged conditions of use. The pins may be stepped on or otherwise mishandled so that one or more of the pins become misaligned (i.e., out of parallel) with the other pins of the male connector. During assembly to a female connector, a misaligned pin may cause damage to the socket. In assembling the male connector to a female connector, even if the pins are not misaligned, molded connectors are frequently subjected to rough handling so that one or more of the pins of the male connector are not properly aligned with the axis of the associated female socket into which it is being inserted. This can also cause damage to the socket elements.
Thus, a common failure is caused by misalignment of the pin during insertion. This can cause a bending of the flexible finger at the inlet opening of the socket because the finger extends beyond, and is therefore not supported by, the surrounding metal cylindrical sleeve. The damage is exacerbated because of the shape of the fingers (i.e., semi-cylindrical) and because of the characteristics of the type of brass material from which these contacts are conventionally made. That is, they are machined from a brass alloy which is somewhat brittle so that it rather easily is deflected beyond its normal stress-deflection characteristic. When this occurs, the metal is overstressed and may even tear. In either case, it will lose its resilient characteristic; and its ability to establish reliable electrical continuity is then lost.
A second problem which also results from the stiffness and shape of the semi-cylindrical fingers of the prior art construction is that they are susceptible to damage if a pin having a diameter larger than that for which the female connector is designed, is inserted into the female socket. Again, the rugged conditions of industrial applications must be borne in mind. It is not uncommon for a user to force an oversized pin into a smaller socket. If an oversized pin is attempted to be assembled to a smaller female socket, the inlet ends of both semi-circular fingers are bent outwardly and about the edge of the protecting sleeve where failure occurs if the fingers are bent with sufficient force.
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Our One Year Anniversary just past and we celebrate in this episode! We continue our Star Trek The Next Generation movie discussion with Star Trek Nemesis and what we would have liked to have seen in a fifth movie. The crew also reveal what you picked as your favorite TNG movie.
Sit back, relax, and escape into the Star Trek Universe with us here on the Four Eyed Radio Network!
Download Episode or Stream in Your Browser:
Blogtalk Radio
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import React, { ReactElement } from 'react';
import { render } from 'react-testing-library';
import { Provider } from 'react-redux';
import Theme from 'common/lib/components/Theme';
import configureStore from '../pages/Editor/store/configureStore';
import { IState } from '../pages/Editor/store/reducer';
export const renderWithTheme = node => {
return render(<Theme host={'EXCEL'}>{node}</Theme>);
};
// re-export everything
export * from 'react-testing-library';
export const renderWithRedux = (
ui: ReactElement<any>,
{ initialState }: { initialState: Partial<IState> },
) => {
const store = configureStore({ initialState });
return { ...renderWithTheme(<Provider store={store}>{ui}</Provider>), store };
};
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Promising Pedagogy: Advancing the Educational Experience of Queer Students Through Transformative Leadership.
The school experience for queer youth is often quite different from that of their heterosexual and gender-conforming peers; yet it is often the c ase that little attention is given to the disparate and inequitable educational and social conditions under which lesbian, gay, bisexual, transgender, and queer/questioning (LGBTQ) youth must learn. In fact, the entirety of pedagogical structures in many schools creates milieus where queer youth, those who have loved ones who are queer, and those who are merely perceived to be queer are systematically marginalized and deprived of their right to a safe, supportive, and equitable educational experience. Transformative leadership theory (TLT) inspires educational leaders to create inclusive and excellent schools for all youth. Neither a prescriptive model nor a process-oriented theory, TLT offers eight tenets that operate in concert to form an authentic way of being informing and guiding leaders' decisions and actions toward the goal of individual, organizational, and societal change.
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All releases of iF.SVNAdmin
Release Notes: The repository browser works on all Windows and Unix platforms now. The basic authentication module supports all types of hashes that Apache provides for the "passwd" file format (SHA1, CRYPT, and MD5).
Release Notes: The table filter no longer hides the table footer buttons (it searches over the whole row now). All user, group, repository, and access path tables have a filter now.
The Repository-Add link is no longer shown if the RepositoryEditProviderType is off. The “selectAll()” function of tables only selects the visible rows. A Chinese translation has been added. The repository browser supports all Unicode characters and shows the latest author and revision.
Release Notes: This release introduces ACL permission management by pre-defined roles. It also comes with the new Project-Manager feature that lets you define Administrators for the different Access-Paths. Basic users are now able to change their own password. There is a new design for the application.
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A Parent's Guide to Anime
Contributor's Biographies
Erica Evans
I'm a chemistry major at the University of Colorado at Boulder, and have been a member of Anime Anonymous *the anime club on campus* for three years. My favorite anime are Cowboy Bebop, Kare Kano, and Excel Saga.
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DAYS: May Sweeps
I hope that the stories play to the characters strengths and relationships. I miss soaps being able to do scenes with a lot of people really well. I thinks Days has gotten better at that as of late. I did love the scene with all the Bradys at the pub the other day. I feel like Kayla is chained to that bar though; has she even seen Horton town square yet?
So Sami and EJ are in her apartment, undressed basically. He ends up on the phone with Billie who is at the ISA and Sami ends up blindfolded and in the safehouse. Bo & Hope goes from ISA to safehouse as well. And Stefano is not mentioned in any of this so he is clearly behind it.
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Computed Tomography Scanning for Early Detection of Lung Cancer.
Parallel and often unrelated developments in health care and technology have all been necessary to bring about early detection of lung cancer and the opportunity to decrease mortality from lung cancer through early detection of the disease by computed tomography. Lung cancer screening programs provide education for patients and clinicians, support smoking cessation as primary prevention for lung cancer, and facilitate health care for tobacco-associated diseases, including cardiovascular and chronic lung diseases. Guidelines for lung cancer screening will need to continue to evolve as additional risk factors and screening tests are developed. Data collection from lung cancer screening programs is vital to the further development of fiscally responsible guidelines to increase detection of lung cancer, which may include small groups with elevated risk for reasons other than tobacco exposure.
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Acumen Fund Uses Entrepreneurial Strategies to Fight Global Poverty
Using entrepreneurial strategies, the international non-profit Acumen Fund aims to fight global poverty. While Acumen’s concerns are traditional as far as international development goes, including water, housing, health and energy, the way that it goes about it is not the norm.
Traditional charities often focus on short-term needs and aid, for instance in times of natural disasters, famines and/or war. This sort of immediate relief creates a dependence and doesn’t allow local communities to play an active role in solving the problem of poverty in the long-term sense. On the other side of the spectrum is a market-based strategy to alleviating poverty, but this has its faults too. Low-income areas are either unattractive to businesses, or completely invisible. So, how does Acumen Fund do it "Dignity, not dependence. Choice, not charity. We combine business an philanthropy to break the cycle of poverty," says Acumen Fund on their website.
Therefore, Acumen Fund takes a bit of both the charity vein and the marketplace vein in order to reinvent the way we look at development. By supporting entrepreneurs that offer crucial services like water, agricultural inputs, health, energy and housing, the Acumen Fund ensures that those who need these services the most can get them at affordable prices.
Acumen Fund’s approach is something called "Patient Capital," which the non-profit describes as "a third way that seeks to bridge the gap between efficiency and scale of market-based approaches and the social impact of pure philanthropy." It’s now clear that the market has failed to provide for certain areas of the world. The emergence of this third space allows business models to bring necessary but affordable products and services. Acumen Fund’s "patient capital" investments aren’t focused on high returns, but giving the ability of enterprises to improve the lives of the poor worldwide.
A business doesn’t have to solely focus on financial return. What social business shows us is that social returns are increasingly possible—and increasingly necessary—in order to bring about social change on a global level. Acumen Fund invests in businesses to serve low-income people all around the world.
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[Prescribe and advise freely].
Physicians know how totally unrealistic it is to expect drug companies to furnish reliable comparative information to assist therapeutic decision-making. All hope in this regard must be founded on personal effort to sort through available data and on independent reasoning. This evaluation process must be based on international nonproprietary names (INN) far removed from the advertising campaigns devised by companies.
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Ultrastructural demonstration of iodine binding and peroxidase activity in the endostyle of Oikopleura dioica (Appendicularia).
The endostyles of cephalochordates, ascidians, and larval petromyzontids have the capacity to organify iodine. A similar mechanism in the appendicularian endostyle has hitherto been unknown. Observations in this study of Oikopleura dioica with electron microscopic autoradiography and cytochemistry show that also the appendicularian endostyle has iodinating capacity and that the iodinating cells contain peroxidase, an enzyme responsible for iodination. After incubation in seawater containing 125I-, autoradiography revealed a selective labeling in the dorsal portion of the endostyle. The endostyle of O. dioica is on each side lined by four rows of corridor cells. The autoradiographic grains were mainly located over the endostylar lumen or associated with the luminal surface of the two central rows of corridor cells. These cells, but no other endostylar cells, also showed a positive reaction for peroxidase. The reaction product was distributed along the luminal plasma membrane and was also present in the cytoplasm within rough endoplasmatic reticulum, Golgi apparatus, and vesicles. The selective labeling as well as the cytochemical reaction were abolished by incubation in methimazole, an inhibitor of peroxidase. It is suggested that the two central rows of the corridor cells can be considered as homologs to iodine-binding zones in other endostyles and also as a primitive forerunner to the vertebrate thyroid gland.
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She will love decorating her favorite bracelet or purse with this gorgeous charm. Featuring a convenient lobster clasp, the girl charm is decorated with a mixture of dazzling clear and lime green crystals. More
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Menu
The Humanity of the Rebel
The love of violence is, to me, the ancient and symbolic gesture of man against the constraints of society. Vicious men can exploit the impulse, but it is a disaster to treat the impulse as vicious. For no society is strong which does not acknowledge the protesting man; and no man is human who does not draw strength from the natural animal.
Jacob Bronowski from The Face of Violence.
I love the insights of Rollo May and I recommend his books to you. Below are some of his thoughts on the rebel in his book, Power and Innocence.
What is the central element that constitutes the human being?
It is the capacity to sense injustice and take a stand against it in the form of I-will-be-destroyed-rather-than-submit. It is a rudimentary anger, a capacity to muster all one’s power and assert it against what one experiences as unfair. However it may be confounded or covered up or counterfeited, this elemental capacity to fight against injustice remains the distinguishing characteristic of human beings. It is, in short, the capacity to rebel.
In the present day, when multitudes of people are caught in anxiety and helplessness, they tend psychologically to freeze up and to cast out of the city walls whoever would disturb their pretended peace. Ironically, it is during just those periods of transition when they most need the replenishing that the rebel can give them that people have the greatest block in listening to him.
The rebel is “one who opposes authority or restraint: one who breaks with established custom or tradition.” His distinguishing characteristic is his perpetual restlessness. He seeks above all an internal change, a change in the attitudes, emotions, and outlook of the people to whom he is devoted. He often seems to be temperamentally unable to accept success and the easy it brings; he kicks against the pricks, and when one frontier is conquered, he soon becomes ill-at-easy and pushes on to the new frontier. He is drawn to the unquiet minds and spirits, for he shares their everlasting inability to accept stultifying controls. No matter how much the rebel gives the appearance of being egocentric or of being on an “ego trip,” this is a delusion; inwardly the authentic rebel is anything but brash.
He rebels for the sake of a vision of life and society which he is convinced is critically important for himself and his fellows. Every act of rebellion tacitly presupposes some value. The rebel does not seek power as an end and has little facility for using it; he tends to share his power. The rebel fights not only for the relief of his fellow men but also for his personal integrity.
The humanity of the rebel lies in the fact that civilization rises from his deeds. The function of the rebel is to shake the fixated mores, and the rigid order of civilization; and this shaking, through painful, is necessary if the society is to be saved from boredom and apathy. Civilization gets its first flower from the rebel.
The rebel insists that his identity be respected; he fights to preserve his intellectual and spiritual integrity against the suppressive demands of his society. He must range himself against the group which represents to him conformism, adjustment, and the death of his own originality and voice.
The rebel rises from the society, criticizes it, and aligns himself with those who are trying to reform it; and all the while he is a member of the very culture he opposes.
The rebel is continually struggling to make the society into a community. In our particular day, the rebel fights the mechanizing bureaucratic trends not because these in themselves are evil, but because they are the paramount modern channels for the dehumanizing of man, the stultifying loss of integrity, and the indignity of man.
For the rebel does what the rest of us would like to do but don’t dare. Through his rebellion the rebel saves us. Civilization needs the rebel.
I salute the rebels in our organizations, institutions, and communities for they are the energy of renewal and growth.
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Latest smartlipo review
Both the salon and the therapist were very nice but the experience is not exactly what it says in the description. There is no full body exfoliation or massage. The therapist exfoliated and wrapped my stomach and leg areas and then I sweated it out for the next hour and a half.
Actually it would have been a lot nicer with a bit of a head massage or something to help relax. It is quite hot and uncomfortable lying there and the salon is noisy so it is quite hard to relax.
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Regulation of voltage-dependent Ca2+ channels in the early developing heart: role of beta1 integrins.
In contrast to adult ventricular cardiomyocytes the developmentally early stage cardiomyocytes show a suppression of the basal voltage-dependent calcium channels (DCC L-type Ca2+ channels, I(Ca)) by carbachol (CCh). This effect is mediated by the endothelial NO-synthase (NOS III). In contrast late stage and adult cardiomyocytes a direct coupling of the muscarinic receptor to the adenylyl cyclase. Thus, NO may function as an early signal transduction molecule during development. This review elucidates the role of beta1-integrins in mediating signal transduction between muscarinic receptors and coupled downstream target proteins such as ion channels. The key finding is that in embryonic stem cell-derived cardiomyocytes deficient of beta1-integrins, the modulation of L-type Ca2+ channels via the M2 receptor is absent. Experiments indicate that this selective signaling defect occurs at the G-protein level. This suggests a novel critical role for integrins in membrane delimited signal transduction processes.
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Arlington House
Arlington House may refer to:
Arlington House, The Robert E. Lee Memorial
Arlington House (London) a hostel for the homeless in London, England, and one of the Rowton Houses
Arlington House, Margate, an eighteen-storey residential apartment block in Margate, Kent, England
Arlington House in London, the demolished home of Henry Bennet, 1st Earl of Arlington on the site of Buckingham Palace
Arlington House Publishers, a now-defunct American book publisher that published jazz discographies, as well as conservative, anti-communist titles
Arlington Beach House, one of the first hotels built in Saskatchewan and was one of the first buildings constructed along Last Mountain Lake
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Infinity Longwear Mascara - Lush lashes can now be yours! This is a luxurious mascara with a whipped formulation that allows for buildable results. It is both lengthening and curling giving depth and dimension to lashes and eyes. It is also long-lasting and water resistant.
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Natalizumab discontinuation and disease restart in pregnancy: a case series.
The humanized monoclonal alpha4-integrin antibody Natalizumab (NTZ) (Tysabri(©) , Biogen Idec, Cambridge, MA, USA) has shown to be effective in multiple sclerosis (MS) therapy; however, the interruption of the drug has been related to a disease restart. This risk has to be carefully considered in case of accidental or desired pregnancies. To report the risk of disease restart in patients who interrupted NTZ because of pregnancy and discuss the implication of NTZ choice in female childbearing patients with MS. Clinical histories and MRI images of four pregnant women with MS who interrupted NTZ. Despite pregnancy is usually related with disease stability, the cases presented here showed an abrupt increase of disability with high number of MRI lesions, some of them with a mass effect. We recommend that female patients on childbearing age must be informed before starting NTZ treatment of the risk of a return of disease activity when the drug is discontinued. The risk occurs even during pregnancy a condition that is considered as protective for women with MS.
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Whoa, now this is a cool idea. The Emscripten guys are back at it again compiling LLVM itself to JavaScript to run in the browser. Now you can compile and run LLVM IR assembly directly in the browser using LLVM.js.
Emscripten, for those that don’t know is an LLVM bytecode to JavaScript compiler. LLVM is a compiler backend for many languages like C and C++ via the Clang compiler, Objective-C and several others. Those compilers generate LLVM bytecode which LLVM normally compiles to native machine code, but Emscripten replaces that output with JavaScript instead, enabling programs written in any language supporting LLVM to be run wherever JavaScript runs.
LLVM.js takes Emscripten a step further by compiling LLVM itself to JavaScript, using Emscripten (which uses LLVM). Whoa! This means that you can now compile and run LLVM assembly directly in JavaScript without installing the native LLVM tools. If language compilers supporting LLVM such as Clang were also compiled to JavaScript, you could compile and run C/C++ code directly in JavaScript as well.
This is a very cool demo. I’m not sure how practical it really is to wait until runtime to compile your code rather than precompiling it, but it could be useful to avoid having to install the LLVM tools, or for platforms where the LLVM compiler cannot run (such as mobile operating systems).
Check out the code on Github, and try your hand at LLVM assembly on the demo page.
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Comparison of novel physiological load-adaptive control strategies for ventricular assist devices.
Terminal heart failure (HF) is the most prevalent cause of death in the Western world and the implantation of a left ventricular assist device (LVAD) has become the gold standard therapy today. Most of the actually implanted devices are driven at a constant speed (CS) regardless of the patient's physiological demand. A new physiological controller [power ratio (PR) controller], which keeps a constant ratio between LVAD power and left ventricular power, a previous concept [preload responsive speed (PRS) controller], which adds a variable LVAD power to reach a defined stroke work, and a CS controller were compared with an unimpaired ventricle in a full heart computer simulation model. The effects of changes in preload, afterload and left ventricular contractility are displayed by global hemodynamics and ventricular pressure-volume loops. Both physiological controllers demonstrated the desired load dependency, whereas the PR controller exceeded the PRS controller in response to an increased load and contractility. Response was inferior when preload or contractility was decreased. Thus, the PR controller might lead to an increased exercise tolerance of the patient. Additional studies are required to evaluate the controllers in vivo.
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Q:
Why does sbt exit while executing tests with no errors?
I've been using SBT to run unit tests on my code, and made some changes recently that have caused the tests to start acting weird.
None of the tests that I have seen fail, but when running the tests with sbt, it just stops in the middle and closes without giving an error message. There are no failed tests in the output.
Does anyone know why this might happen, or how I could figure out what the problem is?
A:
Thanks to the comment by @johanandren, I managed to nail it down to an exception that was being thrown by forcing sbt to fork the tests in a new process. The exception was a java.io.EOFException disguised as an sbt out of memory error -- java.lang.OutOfMemoryError: PermGen space -- and increasing it using the -XX:MaxPermSize argument in the SBT_OPTS environment variable as described in SBT runs out of memory helped fix that issue.
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Web based social networking has become a popular way for people to meet other people over the Internet. Typically, social networking is implemented by websites that provide a dedicated social networking service. Social networking services are typically stand alone web-based services.
To use a web-based social networking service, a user may provide information to setup an account with a social networking service. Once a user's account is configured, users can generate “profiles” of themselves. The profiles typically contain basic information about a user (such as location, occupation, hobbies, etc.).
Social networking services allow users to view other user profiles, join groups with a common subject or theme, add other registered users to a contact list, and send messages to other users having an account with the particular networking service. As stand alone web services, users must generate an account and develop a “network” over time. Messages sent to other users are typically sent as text-based messages, sometimes containing formatting and other markup, and are handled entirely by the social networking system. Communication is typically limited to other users having an account with the networking service. Thus, a user may not send a message to a mail address outside the social networking service other than an invitation to join the social networking service.
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Uniformity and diversity of calcium metabolism in hypertension. A conceptual framework.
Calcium metabolism plays an important role in blood pressure homeostasis, although it remains unclear to what extent calcium contributes to or, alternatively, protects against clinical hypertension. To resolve this confusion, hypertensive subgroups were first defined by plasma renin activity, dietary salt sensitivity, sensitivity to calcium channel blockade, and calcium metabolic indices. Using these classification schemes, different patterns of calcium metabolism emerged, each predictive of divergent clinical responses. Patients with low plasma renin activity, low serum ionized calcium levels, and dietary salt sensitivity, such as black and elderly hypertensive patients, may preferentially benefit from calcium supplementation. It is postulated that calcium-regulating hormones and the renin-angiotensin-aldosterone system coordinately monitor dietary mineral intake, and transduce these environmental signals at the cellular level by altering cellular calcium uptake and disposition. Analysis of these hormonal systems is useful diagnostically in defining those patients who would most benefit from non-pharmacologic dietary forms of treatment.
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Report: God The Father Has Been Telling Everyone Dad Jokes For All Eternity
HEAVEN—According to sources from on high, God the Father continues to insist on telling everyone in heaven dad jokes for all eternity.
"Hey, do you know how you can tell that I like baseball?" He reportedly asked God the Son shortly after creating the universe.
Jesus sighed. "How, Father?"
"In the big inning! Get it? Ha!"
Nobody laughed. But the Father was just getting started. "Hey Jesus, remember when we created everything under there?”
The only begotten Son replied “Under where?” causing the angels to burst out in laughter.
When Cain committed humanity's first murder, the Trinity was watching from on high. "Hey guys," the Father said. "Why couldn't Cain please God? Because he wasn't Abel!"
He also made a joke about how Abraham and Isaac built a computer together and God provided the RAM.
“Hey, guys, who else besides me doesn’t have any parents?” the Father asked at one point during the conquest of Canaan.
Michael the archangel rolled his eyes: “Who?”
“Joshua Son of Nun! Classic!" The Father also confirmed He named Joshua Son of Nun specifically so he could tell that joke.
This has been going on for all eternity, according to sources, and reportedly will continue for all eternity future.
Get Free Access To Our Brand New Site: Not the Bee After creating The Babylon Bee in six literal days, Adam Ford rested. But he rests no longer. Introducing Not the Bee — a brand new humor-based news site run by Adam himself. It's loaded with funny content and all the best features of a social network. And the best part? Everyone with a subscription to The Bee gets full access at no extra cost. Get FREE Access *with premium subscription to The Babylon Bee
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Q:
String.split(String regex) Symbol avoidance
I have
String text2 = "Samaras did something by Papandreou's government.";
When I use
String[] w2 = text2.split("\\s+");
it takes the "Papandreou's" as a whole word (as its supposed to do). But how can I avoid the 's after the word?
A:
text2.split("(\\'s)?\\s+");
This regular expression splits the 's as optional, so it means either "Split 's follow with spaces" or "Split only spaces".
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A Look at Some of the Different Nursing Specialties
If you are a nursing student, or even already an RN, there are different specialties you can consider. Nursing is a great career path, as it offers so many different areas in which you can work. Also, no decision has to be final. You could quite easily change specialty during your career with just a little further training or education. Here are some of the options you could consider.
Pediatrics
Working with children is one of the most challenging, and yet most rewarding, branches of medicine. It can be truly horrific watching children suffer, and not all nurses are cut out for this kind of role. However, knowing you can help, even if it’s in small ways, to make their lives better, is a wonderful feeling. If you are wondering, how do I become a pediatric nurse practitioner? Look at an online pediatric nurse practitioner degree to help you get started, and find out more about this fantastic career path.
Geriatrics
Working with the elderly again brings its own set of challenges. There are options to work outside of hospitals, in old people’s homes, or as part of a community nursing team. With the population ever increasing in age, more and more healthcare professionals with these specialist skills are required, so you would never be short on options.
Research
If you don’t feel like working with patients day to day is the right path for you, becoming a research nurse would be a great option. You would be at the forefront of medical science, helping to make discoveries, and change medicine today, to save countless lives in the future.
Practice
Working as a nurse in a GP practice is a great choice for those looking for some flexibility of work. GP practices offer a range of work, and no two days would be the same. However, the hours are a lot more flexible than in some other roles, and you could even work part time.
Management
Nursing experience and qualifications could help you go into management, either as a nursing manager, leading a team of nurses in a hospital, or community team, or as a manager of a healthcare practice. Either of these options would require fantastic management and organization skills, as well as great healthcare knowledge.
Mental Health
Mental health nursing is a different role again. Mental health is often not talked about, or not seen in the same light as physical health. Working as a mental health nurse, you would not only be looking after patients, but also helping to educate and promote mental health issues and treatments, to help break down these barriers.
Midwifery
Midwifery is about much more than simply delivering babies. You look after mothers, and families, throughout pregnancy, as well as being the first point of call in those all-important, and special first few weeks. Many women never forget their midwife and the help they were given.
These are just a few options, the full list is incredibly long. Nursing offers many options, and a nursing degree can lead to a bright and rewarding future.
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In shower units, the water from the pipe where the mixer and/or closure valve is positioned, is conveyed to a rose at the end of the unit. The rose is often bell-shaped, closed at the bottom by the nozzle where a mass of very small holes are distributed, through which water, in the form of many minute jets, is sprayed like rain on the user.
The nozzle is usually made of plastic and has a cylindrical trunk shape with a hole in the middle via which it is screwed onto the rose or metallic supporting structure.
With another alternative, the edge of the nozzle is rolled over and held together with the rose by a threaded ring. Lastly there are other technical alternatives wherein the nozzle is attached to the rose which feeds it with the water to be sprayed.
Regardless of the type of anchorage and its particular shape, the nozzle is equipped with many minuscule holes which perforate it, in some cases having a cylindrical shape, in others having a shape that is initially a truncated cone and then cylindrical at the extreme that starts inside the rose.
A nozzle structure with spray perforations made in this way facilitates the formation and accumulation of lime scale therein, and therefore the blockage of these perforations so that the unit becomes unusable.
What, in fact, happens with the shower unit is, when the regulator for the water flow housed inside the pipes before the rose is turned off, not all the water comes out. A portion of the water remains in the rose due to depression in the pipe. Due to capillary and surface tension effects, the minuscule spray perforations retain water inside where it slowly evaporates due to the relatively high temperature that the rose reaches during the downflow of water which is normally heated.
Lime scale and solid substances dissolved in the water and incrustations, build up particularly around the fine spray holes until they cause them to clog up.
Following this, it is necessary to disassemble the nozzle and, remove it from the rose, clean it with liquid solvents capable of dissolving the lime scale or with fine needles which, when pushed into the perforations with the intention of freeing them of the lime scale, cause them to be widened and so, over time, the nozzle undergoes damage.
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The limited evidence available suggests that most human cancers are likely the result of genetic transpositions. Through various rearrangements and accumulated mutations, which are now believed to occur commonly in human somatic cells, changes in activation and repression of specific genes, reflected in expression of enzymes, their isozymes and structural proteins, are considered to be the fundamental mechanisms by which the development and progression of a carcinoma are controlled. In this study, I intend to establish systematically the enzyme and isozyme differences and the differences in cell surface proteins between normal and malignant human mammary epithelial cells; the effect of mammotropic hormones on these differential expressions of isozymes and cell surface proteins; and whether this expression is useful in diagnosis and prognosis of human breast cancers. The studies are currently being carried out using a defined system to culture normal and malignant mammary epithelial cells. Work in progress suggest that normal and malignant human mammary epithelium exhibit differences in expression of certain specific enzymes and isozymes. Cell surface reactivities with specific plant lectins have also been found to distinguish normal from malignant breast tumor cells. Efforts are being made to characterize these cellular-biochemical properties unique to neoplastic human breast cells and to identify additional isozymes and cell surface proteins unique in type or amount in malignant human breast tumor cells. The possibility of using these characters as diagnostic and prognostic markers for breast cancer will be assessed.
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Growers shipping their products to distant places encountered the difficulty of having the live plants arrive both alive and without damage. Damage occurs when the plants, and/or the growing medium, becomes dislodged from the containers. This is especially a problem when the shipping container becomes inverted during transportation. When inverted, the weight of the containers crushes the plants so that upon arrival the plants are no longer usable.
The present solution is to offer credits and rebates for the plants damaged during shipping. Previous attempts at shipping live products have included the use of plastic overwrap. This approach has the drawback that live plants need exposure to air and sealing them with plastic does not allow respiration necessary for live plants. Another approach has been to use a plastic netting to hold the plants within their containers. Netting has proved insufficient in that plants are still able to fit within holes in the netting and become damaged.
There is a need in the art for a system for shipping live plants that protects plants from becoming dislodged from their containers and prevents crushing of the plants if the container becomes inverted during shipping.
It is an object of the invention to provide a system for shipping live plants.
It is another object of the invention to provide a covering for plants within containers maintaining the plant within the container but allowing for respiration.
It is another object of the invention to provide a shipping system preventing crushing of plants when the shipping container is inverted.
It is another object of the invention to provide a shipping system for live plants minimizing the loss of plants during shipping.
It is still another object of the invention to provide a shipping system which is simple and inexpensive to use.
It is yet another object of the invention to provide a shipping system for live plants that safely ships a multitude of plants simultaneously.
These and other objects of the invention will become apparent to one of ordinary skill in the art after reviewing the disclosure of the invention.
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LOCK ON The New World LOCK ON The New World
Have confidence and jump into the new world Jump into
LOCK ON The New World LOCK ON The New World
Lets sow creative and fantastic seeds
Go! Go! To the unknown world Give a provocative sideways glance
Get rid of the brakes and And double the speed you're moving at
The more dangerous impulses you know No one can stop you
Every time you learn about the self you didn't know Scared scared scared mummy
LOCK ON The New World LOCK ON The New World
Pioneering in my own way Pioneering
LOCK ON The New World LOCK ON The New World
Carrying on my back the missle of shining miracles
LOCK ON LOCK ON LOCK ON The New World
The encounters rain down And pile up one by one
That seed becomes a flower becomes
Even if I'm doubted I'll believe in my
Missile and destroy everything
LOCK ON The New World LOCK ON The New World
Have confidence and jump into the new world Jump into
LOCK ON The New World LOCK ON The New World
Lets sow creative and fantastic seeds
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H.— The Story of Heathcliff's Journey Back to Wuthering Heights is filled with surprises. The identity of Heathcliff’s mentor/teacher will surprise you. The depths of Heathcliff’s revenge will shock you. The ending might bring satisfaction to those who wish Heathcliff and Cathy had not been doomed lovers. Fans of Emily and Charlotte Brontë will not be disappointed. More info →
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ROBINSON CRUSOE – CLASSIC TALE – IN CINEMAS MAY 6TH
On a tiny exotic island, Tuesday, an outgoing parrot, lives with his quirky animal friends in paradise. However, Tuesday can’t stop dreaming about discovering the world. After a violent storm, Tuesday and his friends wake up to find a strange creature on the beach: Robinson Crusoe. Tuesday immediately views Crusoe as his ticket off the island to explore new lands. Likewise, Crusoe soon realizes that the key to surviving on the island is through the help of Tuesday and the other animals. It isn’t always easy at first, as the animals don’t speak “human.” Slowly but surely, they all start living together in harmony, until one day, when their comfortable life is overturned by two savage cats, who wish to take control of the island. A battle ensues between the cats and the group of friends but Crusoe and the animals soon discover the true power of friendship up against all odds (even savage cats).
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