enelpol/rag-mini-bioasq-with-metadata · Datasets at Hugging Face

question stringlengths 13 215	answer stringlengths 2 3.15k	id int64 1 4.72k	relevant_passage_ids sequencelengths 1 157
What is the effect of amitriptyline in the mdx mouse model of Duchenne muscular dystrophy?	Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy	1,311	[ 24972834 ]
Does thyroid hormone affect cardiac remodeling ?	Cardiac function and mechanics are significantly affected by low thyroid function. l-T4 therapy improves but does not completely recover cardiac function in patients with mild hypothyroidism. Long-term T4 treatment after myocardial infarction has beneficial effects on myocyte, arteriolar, and collagen matrix remodeling in the non-infarcted area. Most importantly, results suggest improved survival of myocytes in the peri-infarct area.	1,152	[ 24114432, 23532677, 24187401, 19107595, 23554452, 24246300, 21568669, 23990180, 9489964, 23958074, 17315395, 16719939, 24159562, 19125327, 23762386, 24217559, 24152286, 24322910, 19096930, 24157158, 22649319, 14704232, 24195179, 24014964, 24315768, 23555069, 23409791 ]
List causative genes for autosomal recessive forms of monogenic Parkinson's disease	Causative genes for autosomal recessive forms of monogenic Parkinson's disease are: PARK2 PARK7 PINK1 PARK9 PARK14 PARK15	324	[ 22166400, 19168133, 17704838, 22427796, 12446870, 15525661, 14712351, 11128611, 18175395, 18787878, 16003110, 22166450, 11911988, 21626549, 11261251, 15917645, 18279377, 11487197, 17713119, 17713120, 10072423, 24244333, 20696312, 19297401, 24167038 ]
What are the 4 types of holoprosencephaly?	Holoprosencephaly is a rare congenital disorder which results from failure of cleavage or incomplete differentiation of the forebrain structures at various levels or to various degrees . Depending on the degree of involvement, it is classified into 4 types: Alobar, Semilobar, Lobar, and Middle interhemispheric fusion variant .	3,997	[ 15301825, 6431778, 28050387, 17001700 ]
List the components of the COMPASS complex	MLL4 MLL3 WDR5 RBBP5 ASH2 SET1	3,272	[ 25706881, 29785026, 25189621, 29404406 ]
What is the inheritance pattern of Li–Fraumeni syndrome?	Li-Fraumeni syndrome shows autosomal dominant inheritance.	776	[ 2190528, 9302689, 22672556, 7981072, 20075382, 16772121 ]
Is the gene CDKN2A nevogenic?	Yes, CDKN2A is nevogenic	2,558	[ 15304099, 12406345, 28830827, 10620111, 475444 ]
What is a mitochondrial nucleoid?	A naked mtDNA molecule is longer than a typical mitochondrion and is therefore compacted in vivo to form a nucleoprotein complex, denoted the mitochondrial nucleoid.	242	[ 23637282, 20577028, 19703654, 15126284, 23220174, 19704786, 23721879 ]
How many amino acids does davunetide consist of?	Davunetide or NAP is an eight amino acid peptide.	2,395	[ 25505609 ]
What are the effects of 14-3-3 dimers on Tau phosphorylation?	14-3-3 dimers regulate steady-state phosphorylation of both wild-type and the R406W mutant Tau, but they are not essential for toxicity of either variant. Furthermore, recruitment of dimers on accumulating wild- type Tau increases its steady- state levels ostensibly by occluding access to proteases in a phosphorylated-dependent manner.	3,301	[ 29659825 ]
Which key gene is involved in interstitial 6q25 microdeletion syndrome?	Interstitial deletions of the long arm of chromosome 6 are rare. Clinically, these deletions are considered to be part of a unique microdeletion syndrome associated with intellectual disability and speech impairment, typical dysmorphic features, structural anomalies of the brain, microcephaly, and non-specific multiple organ anomalies. ARID1B is the key gene behind 6q microdeletion syndrome.	3,971	[ 26754677 ]
What is a likely origin of intronless genes?	More than half of SEGs identified in most of the species have at least one ortholog multiple exon gene in the same genome, which provides insight to their possible origin by retrotransposition	4,022	[ 16469316, 15325254, 13677319, 26415210, 21620332, 22732409, 24820954, 21860604, 10843807 ]
Which medication should be administered when managing patients with suspected acute opioid overdose?	Naloxone is opioid anagonist that should be administered for all patients with suspected acute opioid overdose. Intravenous naltrexone hydrochloride is usually administered, however, other formulations, including enteral methylnaltrexone, nebulized naloxone and subcutaneous naloxone, are under investigation and can be used under certain circumstances.	981	[ 21044832, 8907145, 11015242, 9562190, 11130352, 1470965, 17849242 ]
Should nerinetide be used for treatment of ischaemic stroke?	Nerinetide did not improve the proportion of ischemic stroke patients achieving good clinical outcomes after endovascular thrombectomy compared with patients receiving placebo.	4,001	[ 32087818, 33148815 ]
Are shadow enhancers associated with development?	Yes. Critical developmental control genes sometimes contain shadow enhancers that can be located in remote positions, including the introns of neighboring genes	1,394	[ 20797865, 24055171, 20512118 ]
What is HbVar?	HbVar (http://globin.cse.psu.edu) is a relational database of hemoglobin variants and thalassemia mutations. Extensive information is recorded for each variant and mutation, including a description of the variant and associated pathology, hematology, electrophoretic mobility, methods of isolation, stability information, ethnic occurrence, structure studies, functional studies, and references. The initial information was derived from books by Dr. Titus Huisman and colleagues [Huisman et al., 1996, 1997, 1998]. The current database is updated regularly with the addition of new data and corrections to previous data. Queries can be formulated based on fields in the database. Tables of common categories of variants, such as all those involving the alpha1-globin gene (HBA1) or all those that result in high oxygen affinity, are maintained by automated queries on the database. Users can formulate more precise queries, such as identifying "all beta-globin variants associated with instability and found in Scottish populations." This new database should be useful for clinical diagnosis as well as in fundamental studies of hemoglobin biochemistry, globin gene regulation, and human sequence variation at these loci.	302	[ 14681476, 17221864, 21932936, 11857738, 24137000 ]
Does atemoya juice inhibit the CYP1A2 enzyme?	Yes, atemoya juice inhibits the CYP1A2 enzyme.	4,587	[ 34881402 ]
Is KAT2A involved in Acute myeloid leukemia (AML)?	Yes. The KAT2A gene encodes a receptor tyrosine kinase that is frequently mutated in human acute myeloid leukemia (AML). Activating mutations in Kat2A in response to aberrations in TRAIL can lead to TRAIL-1 activation, resulting in the up-regulation of key AML genes, such as TGFb1, NF-kB, Akt, IKK-1, FOXO1, ERK1/2 and c-Myc.	3,377	[ 27760321 ]
Where is the respirasome located?	Respirasomes are macromolecular assemblies of the respiratory chain complexes I, III and IV in the inner mitochondrial membrane. The 4.0 Å cryo-EM structure of one of the most intricate enzyme systems, the respirasome, in the mitochondrial inner membrane is now available.	1,903	[ 27830641, 27912054 ]
What has pimavanserin been approved for by the FDA (2018)?	Pimavanserin was approved for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.	3,496	[ 28493654 ]
In clinical trials, the H3 R antagonist CEP-26401 has a positive effect on cognition, yes or no?	The H3 R antagonist CEP-26401 had an effect on cognition.	3,010	[ 18469850, 22001260, 27222271 ]
Are there Conserved Noncoding Elements (CNEs) in invertebrate genomes?	Yes.	1,298	[ 19492354, 23357263, 18402933, 24282393, 17274809 ]
What are 2 organisms that can cause Human toxocariasis?	Human toxocariasis , a worldwide parasitic disease , is caused by the larval stage of intestinal nematodes of dogs and cats , namely Toxocara canis and Toxocara cati	3,190	[ 18179629, 29733009, 30050644, 28761463, 24808249, 25910623 ]
Which miRNA is associated with the circular RNA ciRS-7?	circular RNA-7 (ciRS-7) acts as a sponge of miR-7 and thus inhibits its activity.	2,704	[ 28253710 ]
Which network analysis method can you use for prioritization of metabolic disease genes?	metPropagate is a network-guided propagation of metabolomic information for prioritization of metabolic disease genes. metPropagate was able to prioritize at least one causative gene in the top 20th percentile of candidate genes for 92% of patients with known IEMs.	3,881	[ 32637154 ]
Is Titin the largest single protein molecule found in Nature?	Titin, is definitely the largest protein in the body, with a molecular weight of 3 million Dalton and composed of 27,000 amino acids. Titin is the largest protein known to date and acts as a mechanosensor that regulates muscle protein expression in a sarcomere strain-dependent fashion.	1,478	[ 1859393, 21257761, 1582406, 16453158, 14572168, 2129545, 14600266, 12187564, 19962382, 21075826, 16702235, 19134271 ]
What does davunetide do to microtubules?	Davunetide or NAP is a microtubule-stabilizer.	2,314	[ 24210139 ]
Does Evolocumab improve cognitive function?	No, Evolocumab does not improve cognitive functioning.	2,461	[ 28207168, 28453187, 28813214 ]
Does echinacea increase anaphylaxis risk?	Yes, there is evidence that echinacea use is associated with anaphylaxis.	2,265	[ 9507713, 26593037, 11814277, 28731887 ]
At which kind of individuals is pharmacological treatment of subclinical hypothyroidism effective in reducing cardiovascular events?	Treatment of subclinical hypothyroidism is associated with fewer cardiovascular events in younger individuals, but this issue has not been resolved yet in elderly people.	369	[ 17544610, 23559085, 19114542, 17636722, 19463607, 16026106, 22529180, 16542047 ]
What is the treatment of Riedel disease (thyroiditis)?	Riedel thyroiditis is a rare disorder related to a systemic extracervical fibrotic process of unknown origin. The tratment of choice is the surgical treatment: Corticosteroids may be also useful	1,027	[ 8120524, 21568724, 3287769, 22210556, 11014014 ]
What is the mechanism of action of eprotirome?	Eprotirome belongs to thyromimetics and has selective TRβ1 activity. It has shown to be effective in dyslipidemia by the lipid-lowering action of TH in the liver and also in obesity.	1,537	[ 24440706, 18447589, 20625286, 22542282, 20935564, 22784847, 24731671, 25172631, 23565368, 20220185, 23776891, 20872316 ]
Which type of variants can be called by the VarDict algorithm?	VarDict is a novel and versatile variant caller for both DNA- and RNA-sequencing data. It simultaneously calls SNV, MNV, InDels, complex and structural variants, expanding the detected genetic driver landscape of tumors. It performs local realignments on the fly for more accurate allele frequency estimation.	3,709	[ 27060149 ]
Name an lncRNA associated with dilated cardiomyopathy.	The lncRNA H19 is significantly upregulated in the myocardial tissue in dilated cardiomyopathy.	2,692	[ 28430627 ]
Autophagy is the process where a virus obtains nutrients from it's host, yes or no?	No, autophagy is important in cellular homeostasis for the cell survival mechanism and is involved apoptosis.	3,396	[ 24914338, 24779013, 30544615, 28889353, 29022289, 22475795, 28884441, 31803515 ]
Is CD99 encoded by MIC2 gene?	CD99 is a 32-kDa transmembrane glycoprotein that is encoded by the MIC2 gene	581	[ 10492040, 15359120, 10941840, 8399135, 11037347, 25007147, 22356523, 1867320, 21063743, 10782405, 24322504, 17725386, 10688843, 22020966, 9278313, 9623916, 23644663, 24158076, 15978751 ]
List polyubiquitin binding proteins involved in NF-kappaB signaling.	NEMO A20 ABIN-1 ABIN-2 optineurin p62	2,387	[ 23509369, 23989959, 18995839, 19285159 ]
What are the 3 antidotes for anticoagulant (anti-blood clotting) drugs, including factor Xa inhibitors, as of November 2017.	two potential reversal agents for oral direct factor Xa inhibitors (andexanet alfa and ciraparantag) are at various stages of clinical development. Idarucizumab, a reversal agent for the oral direct thrombin inhibitor dabigatran, was approved by FDA in October 2015.	2,729	[ 27626268, 27789605, 27895055 ]
Which are the characteristics of the Meier-Gorlin syndrome?	The Meier-Gorlin syndrome is a rare autosomal recessive disorder, characterized by the association of bilateral microtia, aplasia or hypoplasia of the patellae, and severe pre- and postnatal growth retardation.	752	[ 11477602, 21358631, 21358632, 25059018, 23144622, 23023959, 10213048, 14564153, 11807867, 7981855 ]
What imaging modalities have been listed as method of choice to diagnose CSF leak?	CT cisternography in the investigation of cerebrospinal fluid rhinorrhoea. CTC is an accurate, well-tolerated procedure and should be regarded as the method of choice for investigation of this condition. ...unenhanced (three-dimensional constructive interference in steady state (3D-CISS)...In conclusion, 3D-CISS is a non-invasive and reliable technique, and should be the first-choice method to localise CSF leak.	1,710	[ 19242563, 11109603, 8519147, 11331153, 19723768 ]
Where can we find the protein dermcidin?	Dermcidin is a secretes protein found mainly in sweat but it is also found in serum.	1,246	[ 23426625, 22448321, 24916439, 24828484, 24652391, 25347115, 22262861, 23626547, 24969620, 24562771, 25485461, 22588119, 25055737, 25271322, 22455996, 25330301, 24991806 ]
Are people with blood group O protected against severe Malaria?	It appears that individuals who are of blood-group O are relatively resistant to the severe disease caused by P. falciparum infection.	464	[ 17959777, 22771625, 23071435, 15814030, 22818742 ]
What is the effect of rHDL-apoE3 on endothelial cell migration?	rHDL-apoE3 has been shown to promote endothelial cell migration.	4,569	[ 34875308 ]
What is the indication for zolmitriptan?	Development of a novel zolmitriptan intracutaneous microneedle system (Qtrypta™) for the acute treatment of migraine	4,091	[ 18028032, 9660035, 10640260, 16575626, 31593739, 11200789, 12083998, 31889312, 9170337, 9071267, 32752932, 14642738, 15992000, 10473025, 11594437, 10210888, 9399012, 9399013, 14743270, 9725543, 9399017 ]
How many clinical trials for off-label drugs in neonates are cited in the literature.	There are no reports on clinical trials of off-label drugs in neonates. An analysis of Pediatric Investigation Plans submitted between 2007 and 2010 shows that neonates were included in the study of 4 products, but it is unknown if the trial drugs are off-label and if the trials are being conducted at all.	107	[ 20821198 ]
Which are the coactivators of the Yes-associated protein (yap)?	The Yap protein forms complex with Tead (TEA domain) transcription factors.	1,292	[ 16332960, 20439427, 25097035, 23380592, 23985334, 22632831 ]
Is cohesin linked to myeloid differentiation?	Yes. There has been a link found between cohesin and myeloid differentiation which may help explain the prevalence of cohesin mutations in human acute myeloid leukemia.	2,787	[ 30127433 ]
Please list symptoms of measles.	The leading symptoms of the disease are high fever that presents after an incubation period of 9-10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. The most commonly occuring satellite symptoms are conjunctivitis, coryza and cough.	2,865	[ 26613224, 29310585, 15230469, 27168928 ]
Gene silencing can be achieved by RNA interference (RNAi) in eukaryotic organisms. What is the name of the analogous process in prokaryotic organisms?	Bacteria have developed several defense mechanisms against bacteriophages over evolutionary time, but the concept of prokaryotic RNA interference mediated defense mechanism against phages and other invading genetic elements has emerged only recently. Clustered regularly interspaced short palindromic repeats (CRISPR) together with closely associated genes (cas genes) constitute the CASS system that is believed to provide a RNAi-like defense mechanism against bacteriophages within the host bacterium.	338	[ 19945378, 20109154, 23439366, 16545108, 21441598, 18971321, 19706170, 17537822 ]
Which hormone deficiency is implicated in the Costello syndrome ?	Growth hormone deficiency is implicated in Costello syndrome. Growth hormone therapy should be administered with caution due to possible severe side effects. Cortisol and sex hormone deficiencies were also implicated in Costello syndrome.	636	[ 19035362, 22752028, 15316966, 14564166, 15316968, 18483625, 20307337, 8168845, 22887473, 17551924, 19258709, 21438134, 16278907, 22821884, 15940703 ]
Does DDX54 play a role in DNA damage response?	Yes. DDX54, a candidate genotoxic stress responsive RNA helicase, regulates transcriptome dynamics during DNA damage response.	2,342	[ 28596291 ]
What is the function of HDAC proteins?	Histone deacetylases influence diverse cellular processes and may contribute to tumor development and progression by multiple mechanisms. Histone deacetylases prevent the relaxation of chromatin, and positively or negatively regulate transcription.	2,700	[ 10220385, 27668865, 23724067, 15050820, 22621256, 23088873, 19443688, 17767915, 27939885, 27345839, 17227860, 11602581, 26927903, 28078999, 10869435, 28930559 ]
What is pyroptosis?	Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and IL-1β. Pyroptosis has been reported to be closely associated to some diseases like atherosclerosis and diabetic nephropathy. Recently, some studies found that pyroptosis can influence the proliferation, invasion and metastasis of tumor, which regulated by some non-coding RNAs and other molecules.	3,985	[ 31733200, 31756255, 31710896, 30917630 ]
What are the effects of ibrutinib on CART cell production?	CART cell generation in the presence of ibrutinib resulted in increased cell viability and expansion of CLL patient-derived CART cells. Furthermore, ibrutinib enriched CART cells with less-differentiated naïve-like phenotype and decreased expression of exhaustion markers including PD-1, TIM-3 and LAG-3. In addition, ibrutinib increased the cytokine release capacity of CLL patient-derived CART cells. In summary, BTK/ITK inhibition with ibrutinib during CART cell culture can improve yield and function of CLL patient-derived CART cell products.	4,382	[ 32683672, 32055000 ]
Which kinase is inhibited by the small molecule KN-93?	The calcium/calmodulin-dependent protein kinase-II (CaMK-II) is inhibited by the small molecule KN-93. KN-93 is a membrane-permeant calcium/calmodulin- dependent kinase II (CaMK-II)-selective inhibitor	119	[ 9596994, 11164895, 1662507, 21187407, 11248432, 10712242, 9864285, 16896952, 15569687, 11827960, 22290426, 17457979, 14749212, 15175389, 7690557, 8939965 ]
List human antibody isotypes.	IgA IgE IgG IgM IgD	3,783	[ 29684416, 29382466, 16157351, 29125655, 20050331 ]
What is the contribution of ultraconserved elements in Australasian smurf-weevils?	Ultraconserved elements (UCEs) resolve the phylogeny of Australasian smurf-weevils.	2,979	[ 29166661 ]
Which receptor is targeted by Spesolimab?	Spesolimab is a novel anti-interleukin-36 receptor antibody.	4,599	[ 33661508, 33919434, 34085329, 33785490, 34678325, 34626330, 32884319 ]
What is Path2PPI?	Path2PPI is an R package to identify protein-protein interaction (PPI) networks for fully sequenced organisms for which nearly none PPI are known. Path2PPI predicts PPI networks based on sets of proteins from well-established model organisms, providing an intuitive visualization and usability. It can be used to combine and transfer information of a certain pathway or biological process from several reference organisms to one target organism.	1,837	[ 26733452 ]
Do genes with monoallelic expression contribute proportionally to genetic diversity in humans?	No, genes with monoallelic expression contribute disproportionately to genetic diversity in humans.	3,706	[ 26808112 ]
Which organs are mostly affected in Systemic Lupus Erythematosus (SLE)?	In systemic lupus erythematosus (SLE), brain and kidney are the most frequently affected organs. The heart is one of the most frequently affected organs in SLE. Skin is one of the most commonly affected organs in SLE. Other affected organs in SLE-AAC included hematologic system (11, 84.6%), followed by mucocutaneous (seven, 53.8%), musculoskeletal (seven, 53.8%) and neuropsychiatric (two, 15.4%) systems.	2,767	[ 24268009, 25186992, 7588946, 28355987, 19758166, 21767292 ]
How does trimetazidine affect intracellular kinase signaling in the heart?	Trimetazidine activates AMPK in diabetic myocardium. Trimetazidine when administered before reperfusion results in activation of p38 mitogen-activated protein kinase and Akt signaling. Trimetazidine when administered during reperfusion does not affect p38MAPK and JNK activation.	441	[ 19546072, 20167841, 20383170, 15616764 ]
Is imatinib an antidepressant drug?	No. Imatinib is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Chronic myelogenous leukemia (CML) and Gastrointestinal stromal tumor (GIST).	1,653	[ 15966213, 23394826, 21087500, 20726677, 19628568, 22484890, 22593820, 22110503, 22135725, 22035758, 21073206, 17554495, 18506179, 20676553, 20442314, 22460758, 16566359, 21938530, 16403813, 22487918, 22831984, 21607924, 22678007, 20407930, 19110398 ]
Which kinase does PD98059 inhibit?	PD98059 is a specific, reversible MEK inhibitor.	4,372	[ 32378175 ]
Is muscle regeneration possible in mdx mice with the use of induced mesenchymal stem cells?	Purified induced mesenchymal stem cells (iMSCs) display fibroblast-like morphology, form three-dimensional spheroid structures, express characteristic mesenchymal stem cell surface markers such as CD29, CD33, CD73, CD90, and CD105, and are capable of differentiating into adipogenic, osteogenic, and chondrogenic lineages. Transplantation of iMSC cells to tibialis anterior skeletal muscle tissue in mdx mice lowers oxidative damage, and restores the expression levels of normal dystrophin, leading to skeletal muscle regeneration.	1,203	[ 17999592, 25102299 ]
What is the relationship between RUNX1T1 and FTO?	FTO controls exonic splicing of adipogenic regulatory factor RUNX1T1 by regulating m6A levels around splice sites and thereby modulates differentiation. The effect of FTO on adipogenesis appears to be mediated via enhanced expression of the pro-adipogenic short isoform of RUNX1T1.	4,268	[ 25881961, 25412662 ]
Which is the execution time (complexity) of the Smith-Waterman algorithm for the alignment of two sequences	The complexity of the Smith-Waterman dynamic programming algorithm is quadratic, that is, it runs in time proportional to the product of lengths of the sequences being aligned.	997	[ 16522182, 14668231, 20370891, 21714130, 1774068, 11301301, 9021270, 12804086 ]
Is Verubecestat effective for Alzheimer's Disease?	No. Verubecestat did not reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease and was associated with treatment-related adverse events.	3,680	[ 28749667, 30347431, 30970186, 29719179, 31387606, 31423903 ]
Are nucleosomes positioned at DNA replication origins?	No, origins of replication occur in nucleosome-free regions in both budding yeast and Drosophila. Open chromatin domains, characterized by nucleosome depletion, are preferentially permissive for replication.	1,370	[ 20351051, 1587867, 21148149, 19463783 ]
Does addition of valproic acid improve survival of patients with diffuse intrinsic pontine glioma?	No. Addition of valproic acid and bevacizumab to radiation was well tolerated but did not appear to improve survival in children with diffuse intrinsic pontine glioma.	4,409	[ 24293221, 32285998 ]
What is the mode of inheritance of Wilson's disease?	Wilson's disease (WD) is an autosomal recessive disorder.	21	[ 8186659, 16932613, 838566, 6620327, 12152840, 22610954, 2724779, 8615372, 1940586, 6109943, 759736, 14580665, 20662462, 1248830 ]
What is known about depression in caregivers of brain tumor patients?	Depression is common affecting up to 40% of caregivers of brain tumor patients. Depression is associated with poor quality of life of caregivers of brain tumor patients. Greater anxiety, patients’ emotional distress, economic hardship, lower caregivers’ age, lower income, less social support and lower patient functioning were associated with more caregivers’ depressive symptoms. Reports of caregiver depressive symptoms were lower when paired with higher reports of spirituality. It is important to monitor and treat caregiver's depression.	1,209	[ 18329220, 16532486, 23187335, 24152975, 21994513, 22307475, 12605978, 17760798, 19159080, 23615145, 21968946, 23438646, 18061752, 23104453, 23384776, 18481737, 22585179, 23633116, 23989499 ]
What is AZD0530 an inhibitor of?	AZD0530 is a highly selective, dual Src/Abl kinase inhibitor.	3,696	[ 22623106 ]
What type of cancers and inherited diseases have been associated to mutations in the Notch pathway?	So far, mutations in Notch and other components of its signaling pathway have been implicated in an array of human diseases (T-cell leukemia and other cancers, Multiple Sclerosis, CADASIL, Alagille Syndrome, Spondylocostal Dysostosis), but more pathologies are likely to be associated with Notch in the future due to its network complexity.	1,332	[ 22891273, 15712272, 22488849, 18775957, 19289631, 22156581, 11180599, 22210878, 20823234, 9585603, 21562564, 16773578, 21196490, 17584081, 23095891, 23359070, 12497640, 20087400, 9207788, 22974708 ]
Which is the causative agent of malaria?	Four Plasmodium species commonly infect humans (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale). Plasmodium falciparum infects about 5-10% of the world human population per year and it is the causative agent of the most severe and lethal form of malaria. P. falciparum causes fatal cerebral malaria and is responsible for most deaths, particularly in pregnant women and children under the age of five. P. falciparum is transmitted to the human host by Anopheles mosquitoes and is the most tremendous malaria vector in sub-Saharan Africa. Plasmodium vivax is the causative agent of benign malaria in more temperate climates of the world. Plasmodium gallinaceum is the main bird malaria causative agent and Plasmodium yoelli is the principle rodent malaria agent.	1,539	[ 21209090, 15265796, 19706885, 15701514, 2067470, 12139027, 1648659, 15463447, 22563351, 23088152, 2067482, 21989409, 23483940, 22592550, 22095915, 8300589, 15073329, 23046708, 18672695, 8631352, 16458301, 9927744, 19801158, 22359643, 9514077, 11085920, 11115107, 22341220, 12930149, 19666023, 15339111, 20610151, 8816746, 15117937, 23484017, 23405174, 22222968, 19706490, 22028927, 22990975, 19038338, 12626578, 21601941, 19380379, 21771420, 11796125, 19779742, 19666593, 21698217, 21904052, 12929205, 14514358, 19020475, 20500669, 19013823, 15246528, 16203971, 15003844, 14638789, 20702404, 3911876, 22628552, 11839179, 18295508, 23349974, 22019287, 22524128, 7715553, 23382752, 22507744, 18221799, 22819049, 18611947, 11687659, 19184366, 15950069, 22543099, 10585859, 17868038, 20078859, 20635416, 1474844, 16042788, 22057268, 6728514, 18082626, 16222020, 23326533, 22216006, 19267910, 18563912, 9874251, 11504465, 1813841, 18628947, 17024857, 2191201, 14556002, 21329764, 21570407, 4047719, 10703207, 21297002, 19768685, 18164079, 18522993, 20353400, 18925948, 21670272, 14627712, 11087748, 22929299, 15703443, 18989463, 23293353, 12125103, 20034997, 18248630, 11559352, 10744765, 21866942, 14609342, 15878595, 6760901, 15147974, 21206476, 23342028, 15293910, 23246819, 15033330, 3011062, 17822713, 19931645 ]
Does burning mouth syndrome preferentially affect post-mepopausal women?	BMS is observed principally in middle-aged patients and postmenopausal women BMS mostly affects elderly citizens, especially postmenopausal women with prevalence up to 12-18%.	249	[ 7838464, 6589575, 9844361, 17541900, 21685517, 16142094, 15055637, 17452954, 18305436, 9237148, 3476895, 18278306, 8469539, 21418666, 23772971, 18985004, 12618668, 12907696, 7629360, 11441716, 10431669, 12764983, 21528120, 20230455, 20440632, 23050296, 21903545, 20597947, 11871678, 10446526, 22030140, 15195716, 16905808, 19450321, 18625105, 8725589, 8170453, 22612823, 23201368, 2700889, 19689438, 17439072, 20038880, 17967714, 20701667, 19658340, 18558051, 24096230, 15024358, 16637799, 12017897, 11603307, 17849966, 10478959, 23787507, 15911160 ]
Which is the most known bacterium responsible for botulism (sausage-poisoning)?	Botulism is a severe neuroparalytic disease caused by botulinum neurotoxin (BoNT), and affects humans, all warm-blooded animals, birds, and some fishes. Botulinum toxin is produced under anaerobic conditions by the bacterium Clostridium botulinum, which is the most known etiological agent of the disease, and some other clostridia, and is one of the most dangerous toxin in the world.	133	[ 24961027, 21171846, 21975066, 24252701, 20961439, 18388640, 15839401, 23239346, 23523511, 24253240, 23421373, 24252222, 17458494, 19573697, 24206405, 21747146, 11153358, 24246230, 23971804, 23971806, 23971808, 15027048, 20569065, 21130733, 24997242, 16080379, 23025151 ]
Is autophagy the process where bacteria ingest viral particles?	Autophagy, a cellular degradation process	2,159	[ 24198400, 21946213, 27812870, 23121192, 24906121, 27814601, 27027951, 24384599, 21175768, 23388380 ]
What are the side effects during statins administration in patients with atherosclerosis?	The side effects during statins administration in patients with atherosclerosis are: 1) Myopathy 2) Transaminase elevations 3) Diabetes mellitus 4) Renal and neurologic adverse effects.	1,938	[ 22913216, 21796961, 26575138, 24788803, 25936326, 27878791, 25644328, 12891851, 19039148, 21972203, 24840269, 17042673, 24601937, 18585718, 25678839, 23299641, 21267417, 26490078 ]
Can radiosurgery be used for the DNET tumors?	Yes, radiosurgery is used for the DNET (Dysembryoplastic neuroepithelial) tumors. However, the level of evidence is limited.	3,978	[ 28868186, 17240596 ]
Which tool has been developed to identify the glycan shielding of glycosylated proteins?	GLYCO (GLYcan COverage) is an in silico approach to quantify the glycan shielding of a protein surface. The software provides insights into glycan-dense/sparse regions of the entire protein surface or a subset of the protein surface. GLYCO calculates glycan shielding from a single coordinate file or from multiple coordinate files, for instance, as obtained from molecular dynamics simulations or by nuclear magnetic resonance spectroscopy structure determination, enabling analysis of glycan dynamics.	4,684	[ 34864901 ]
Is the Fluzone intradermal and the Fluzone intradermal quadrivalent vaccine produced by different companies?	No, the Fluzone Intradermal vaccine and the Fluzone Intradermal Quadrivalent vaccine are produced by Sanofi Pasteur.	3,245	[ 27457797 ]
Which R/bioconductor package exists for discovery of intergenic transcripts?	To increase the power of transcript discovery from large collection of RNA-seq data sets, a novel '1-Step' approach named pooling RNA-Seq and Assembling Models (PRAM) has been developed that build transcript models from pooled RNA- sequencing data sets. PRAM is implemented as an R/Bioconductor package.	4,140	[ 32958497 ]
Is Ameloblastoma (AB) a common benign tumor occurring in the brain?	Ameloblastoma (AM) is a slow growing and aggressive benign tumor with an odontogenic epithelial origin arising from the mandible or maxilla.	4,667	[ 20051072, 34508164, 27721617, 17170964, 28212886, 32698263, 14970780, 25298718, 29274152, 19995435, 28187692, 27099699, 10895162, 32484411, 26261564, 21717310, 28191811, 30420932, 33394372, 21968082, 30126803, 32659412, 25567699, 26925653, 26015700, 1569364, 34599642, 23986011, 31674718, 34510060, 29747056, 21371124, 31990904, 34594553, 30196986, 34511355, 25206141, 27435007 ]
List non-surgical treatment modalities that are included in the Stupp protocol.	Radiotherapy and chemotherapy are non-surgical treatment modalities that are included in the Stupp protocol. This protocol is widely used for treatment of glioblastoma.	1,591	[ 18808066, 25434389, 20428822, 22141608, 24600235, 22359215, 23588276, 22464950, 24287680, 21156036, 21344976, 24111708, 23453151, 25201633, 20045159, 23254891, 20870254, 23535992, 24518393 ]
What organism causes woolsorter's disease	Woolsorter's disease is caused by the same organism as Anthrax, bacillus Anthrax.	1,960	[ 18959192, 15486181 ]
The Shingrix vaccine is used to prevent what disease?	Shingrix is a 4-component vaccine against capsular herpes zoster (4CZV), which has recently been licensed in Europe, Canada and Australia.	4,073	[ 31423396, 31258310, 33163688, 31400911, 31399377, 32999027, 30145235, 30370455, 32606264, 33067034, 32862397 ]
How is myotonic dystrophy inherited?	Myotonic dystrophy (DM) is a heterogeneous neuromuscular disease with an autosomal dominant pattern of inheritance.	613	[ 8154209, 18228241, 12577208, 22332444, 12970845 ]
What is generic name of drug Adempas?	Riociguat is generic name of drug Adempas. It is a soluble guanylate cyclase stimulator that was approved for the treatment of patients with chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.	558	[ 24391396, 24218053, 25395817, 25352393, 24524094 ]
What drug cures hepatitis C?	Sofosbuvir-based therapy cures hepatitis C virus infection	2,629	[ 26085900, 26209383 ]
Austrian syndrome is a rare entity characterized by Osler's triad. Please list the 3 components of Osler's triad.	Austrian syndrome, which is also known as Osler's triad, is a rare aggressive pathology consisting of pneumonia, endocarditis, and meningitis caused by Streptococcus pneumoniae	4,467	[ 31259104, 34710311, 32923368, 29967896, 30254807, 28266699, 14600140, 31659532, 17599001, 22030703, 29848535, 32426357, 18635383, 30880376, 31300377, 19886075, 25218621 ]
Is SMOC2 expressed during wound healing?	Yes, SMOC2 response to wounding.	4,236	[ 34876240, 33710643, 32908163, 32355542 ]
In which nuclear compartments is heterochromatin located?	This compartment localizes into three main regions: the peripheral heterochromatin, perinucleolar heterochromatin, and pericentromeric heterochromatin. Silencing appears to be associated with histone H3 lysine 9 trimethylation (H3K9me3), DNA methylation and the localization of the silenced gene to a specific nuclear compartment enriched in these modification	982	[ 12432450, 22251972, 16254244, 23834025, 20026667, 21283637, 19889207, 15564378 ]
Which methyl-CpG-binding protein when mutant becomes the hallmark for Rett syndrome?	Rett syndrome (RTT) was shown to be caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, with molecular studies identifying MECP2 mutations in up to 80% of classic RTT patients. MECP2 protein was found to assist in the transcriptional silencing process via DNA methylation. We therefore hypothesize that disruption of this gene alters the normal developmental expression of various other genes, some of which must account for the peculiar neurologic phenotype of RTT.	479	[ 22138506, 22302819, 18534925, 11180222 ]
Do Parkinson's disease patients experience stridor?	Yes. Stridor has been described in Parkinon's disease patients. Stridor has been linked to deep brain stimulation and L-Dopa medication use. However, stridor was shown to be more common in multiple system atrophy patients.	1,173	[ 14703107, 12023429, 19010952, 20003593, 6622345, 16575624, 10391085, 19628429, 8353712, 21819188, 7651445, 7785431, 20205147, 12884831 ]
What is the purpose of Macropinocytosis?	Macropinocytosis is an endocytic process, which involves the engulfment of extra-cellular content in vesicles known as macropinosomes.	4,573	[ 34755081, 27647881, 30333835, 14732047, 30617109, 29085336, 27352861, 32745890, 31924779, 25096879, 11029048, 17760832, 10321993, 30725454, 10678991, 30966999, 30967003, 30400219, 30967006, 30967007, 30967008, 30967009, 33520357, 32756454, 27503856, 11890548, 15533943 ]
Which are the main histone modifications associated with enhancers?	Histone 3 lysine 4 mono- (H3K4me1) and di-methylation (H3K4me2) are the main post-transcriptional histone modifications related to enhancer activity.	1,578	[ 20621055, 19021773, 22270183 ]
Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection?	Preimplantation Genetic Diagnosis can be used for gender selection.	1,585	[ 19294755, 19891844, 18222917, 12470342, 20638568, 9329835, 19251775, 18829009, 20102489, 18667646, 12615807 ]
List diseases that are repeat expansion disorders (REDs).	The expansion of Short tandem repeats underlies the pathogenesis of multiple neurological disorders, including Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal dementia, fragile X-associated tremor/ataxia syndrome, and myotonic dystrophies, known as repeat expansion disorders (REDs).	4,596	[ 25726753, 32695777, 8908515, 32589669, 29325606, 26420841, 9302257, 19710035, 25886163, 14526165, 8900536, 32619224, 10766906, 34502075, 34054431 ]
List biomarkers for sepsis.	HCK, PRKCD, SIRPA, DOK3, ITGAM, LTB4R, MAPK14, MALT1, NLRC3, LCK C-Reactive Protein (CRP), Procalcitonin (PCT) and Interleukin 6 (IL-6) sTM	4,474	[ 33274532, 34524647, 33140076, 34517744, 34551574, 32705879, 31537145, 34634653 ]

What is the effect of amitriptyline in the mdx mouse model of Duchenne muscular dystrophy?

Amitriptyline is efficacious in ameliorating muscle inflammation and depressive symptoms in the mdx mouse model of Duchenne muscular dystrophy

1,311

[ 24972834 ]

Does thyroid hormone affect cardiac remodeling ?

Cardiac function and mechanics are significantly affected by low thyroid function. l-T4 therapy improves but does not completely recover cardiac function in patients with mild hypothyroidism. Long-term T4 treatment after myocardial infarction has beneficial effects on myocyte, arteriolar, and collagen matrix remodeling in the non-infarcted area. Most importantly, results suggest improved survival of myocytes in the peri-infarct area.

1,152

[ 24114432, 23532677, 24187401, 19107595, 23554452, 24246300, 21568669, 23990180, 9489964, 23958074, 17315395, 16719939, 24159562, 19125327, 23762386, 24217559, 24152286, 24322910, 19096930, 24157158, 22649319, 14704232, 24195179, 24014964, 24315768, 23555069, 23409791 ]

List causative genes for autosomal recessive forms of monogenic Parkinson's disease

Causative genes for autosomal recessive forms of monogenic Parkinson's disease are: PARK2 PARK7 PINK1 PARK9 PARK14 PARK15

324

[ 22166400, 19168133, 17704838, 22427796, 12446870, 15525661, 14712351, 11128611, 18175395, 18787878, 16003110, 22166450, 11911988, 21626549, 11261251, 15917645, 18279377, 11487197, 17713119, 17713120, 10072423, 24244333, 20696312, 19297401, 24167038 ]

What are the 4 types of holoprosencephaly?

Holoprosencephaly is a rare congenital disorder which results from failure of cleavage or incomplete differentiation of the forebrain structures at various levels or to various degrees . Depending on the degree of involvement, it is classified into 4 types: Alobar, Semilobar, Lobar, and Middle interhemispheric fusion variant .

3,997

[ 15301825, 6431778, 28050387, 17001700 ]

List the components of the COMPASS complex

MLL4 MLL3 WDR5 RBBP5 ASH2 SET1

3,272

[ 25706881, 29785026, 25189621, 29404406 ]

What is the inheritance pattern of Li–Fraumeni syndrome?

Li-Fraumeni syndrome shows autosomal dominant inheritance.

776

[ 2190528, 9302689, 22672556, 7981072, 20075382, 16772121 ]

Is the gene CDKN2A nevogenic?

Yes, CDKN2A is nevogenic

2,558

[ 15304099, 12406345, 28830827, 10620111, 475444 ]

What is a mitochondrial nucleoid?

A naked mtDNA molecule is longer than a typical mitochondrion and is therefore compacted in vivo to form a nucleoprotein complex, denoted the mitochondrial nucleoid.

242

[ 23637282, 20577028, 19703654, 15126284, 23220174, 19704786, 23721879 ]

How many amino acids does davunetide consist of?

Davunetide or NAP is an eight amino acid peptide.

2,395

[ 25505609 ]

What are the effects of 14-3-3 dimers on Tau phosphorylation?

14-3-3 dimers regulate steady-state phosphorylation of both wild-type and the R406W mutant Tau, but they are not essential for toxicity of either variant. Furthermore, recruitment of dimers on accumulating wild- type Tau increases its steady- state levels ostensibly by occluding access to proteases in a phosphorylated-dependent manner.

3,301

[ 29659825 ]

Which key gene is involved in interstitial 6q25 microdeletion syndrome?

Interstitial deletions of the long arm of chromosome 6 are rare. Clinically, these deletions are considered to be part of a unique microdeletion syndrome associated with intellectual disability and speech impairment, typical dysmorphic features, structural anomalies of the brain, microcephaly, and non-specific multiple organ anomalies. ARID1B is the key gene behind 6q microdeletion syndrome.

3,971

[ 26754677 ]

What is a likely origin of intronless genes?

More than half of SEGs identified in most of the species have at least one ortholog multiple exon gene in the same genome, which provides insight to their possible origin by retrotransposition

4,022

[ 16469316, 15325254, 13677319, 26415210, 21620332, 22732409, 24820954, 21860604, 10843807 ]

Which medication should be administered when managing patients with suspected acute opioid overdose?

Naloxone is opioid anagonist that should be administered for all patients with suspected acute opioid overdose. Intravenous naltrexone hydrochloride is usually administered, however, other formulations, including enteral methylnaltrexone, nebulized naloxone and subcutaneous naloxone, are under investigation and can be used under certain circumstances.

981

[ 21044832, 8907145, 11015242, 9562190, 11130352, 1470965, 17849242 ]

Should nerinetide be used for treatment of ischaemic stroke?

Nerinetide did not improve the proportion of ischemic stroke patients achieving good clinical outcomes after endovascular thrombectomy compared with patients receiving placebo.

4,001

[ 32087818, 33148815 ]

Are shadow enhancers associated with development?

Yes. Critical developmental control genes sometimes contain shadow enhancers that can be located in remote positions, including the introns of neighboring genes

1,394

[ 20797865, 24055171, 20512118 ]

What is HbVar?

HbVar (http://globin.cse.psu.edu) is a relational database of hemoglobin variants and thalassemia mutations. Extensive information is recorded for each variant and mutation, including a description of the variant and associated pathology, hematology, electrophoretic mobility, methods of isolation, stability information, ethnic occurrence, structure studies, functional studies, and references. The initial information was derived from books by Dr. Titus Huisman and colleagues [Huisman et al., 1996, 1997, 1998]. The current database is updated regularly with the addition of new data and corrections to previous data. Queries can be formulated based on fields in the database. Tables of common categories of variants, such as all those involving the alpha1-globin gene (HBA1) or all those that result in high oxygen affinity, are maintained by automated queries on the database. Users can formulate more precise queries, such as identifying "all beta-globin variants associated with instability and found in Scottish populations." This new database should be useful for clinical diagnosis as well as in fundamental studies of hemoglobin biochemistry, globin gene regulation, and human sequence variation at these loci.

302

[ 14681476, 17221864, 21932936, 11857738, 24137000 ]

Does atemoya juice inhibit the CYP1A2 enzyme?

Yes, atemoya juice inhibits the CYP1A2 enzyme.

4,587

[ 34881402 ]

Is KAT2A involved in Acute myeloid leukemia (AML)?

Yes. The KAT2A gene encodes a receptor tyrosine kinase that is frequently mutated in human acute myeloid leukemia (AML). Activating mutations in Kat2A in response to aberrations in TRAIL can lead to TRAIL-1 activation, resulting in the up-regulation of key AML genes, such as TGFb1, NF-kB, Akt, IKK-1, FOXO1, ERK1/2 and c-Myc.

3,377

[ 27760321 ]

Where is the respirasome located?

Respirasomes are macromolecular assemblies of the respiratory chain complexes I, III and IV in the inner mitochondrial membrane. The 4.0 Å cryo-EM structure of one of the most intricate enzyme systems, the respirasome, in the mitochondrial inner membrane is now available.

1,903

[ 27830641, 27912054 ]

What has pimavanserin been approved for by the FDA (2018)?

Pimavanserin was approved for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis.

3,496

[ 28493654 ]

In clinical trials, the H3 R antagonist CEP-26401 has a positive effect on cognition, yes or no?

The H3 R antagonist CEP-26401 had an effect on cognition.

3,010

[ 18469850, 22001260, 27222271 ]

Are there Conserved Noncoding Elements (CNEs) in invertebrate genomes?

Yes.

1,298

[ 19492354, 23357263, 18402933, 24282393, 17274809 ]

What are 2 organisms that can cause Human toxocariasis?

Human toxocariasis , a worldwide parasitic disease , is caused by the larval stage of intestinal nematodes of dogs and cats , namely Toxocara canis and Toxocara cati

3,190

[ 18179629, 29733009, 30050644, 28761463, 24808249, 25910623 ]

Which miRNA is associated with the circular RNA ciRS-7?

circular RNA-7 (ciRS-7) acts as a sponge of miR-7 and thus inhibits its activity.

2,704

[ 28253710 ]

Which network analysis method can you use for prioritization of metabolic disease genes?

metPropagate is a network-guided propagation of metabolomic information for prioritization of metabolic disease genes. metPropagate was able to prioritize at least one causative gene in the top 20th percentile of candidate genes for 92% of patients with known IEMs.

3,881

[ 32637154 ]

Is Titin the largest single protein molecule found in Nature?

Titin, is definitely the largest protein in the body, with a molecular weight of 3 million Dalton and composed of 27,000 amino acids. Titin is the largest protein known to date and acts as a mechanosensor that regulates muscle protein expression in a sarcomere strain-dependent fashion.

1,478

[ 1859393, 21257761, 1582406, 16453158, 14572168, 2129545, 14600266, 12187564, 19962382, 21075826, 16702235, 19134271 ]

What does davunetide do to microtubules?

Davunetide or NAP is a microtubule-stabilizer.

2,314

[ 24210139 ]

Does Evolocumab improve cognitive function?

No, Evolocumab does not improve cognitive functioning.

2,461

[ 28207168, 28453187, 28813214 ]

Does echinacea increase anaphylaxis risk?

Yes, there is evidence that echinacea use is associated with anaphylaxis.

2,265

[ 9507713, 26593037, 11814277, 28731887 ]

At which kind of individuals is pharmacological treatment of subclinical hypothyroidism effective in reducing cardiovascular events?

Treatment of subclinical hypothyroidism is associated with fewer cardiovascular events in younger individuals, but this issue has not been resolved yet in elderly people.

369

[ 17544610, 23559085, 19114542, 17636722, 19463607, 16026106, 22529180, 16542047 ]

What is the treatment of Riedel disease (thyroiditis)?

Riedel thyroiditis is a rare disorder related to a systemic extracervical fibrotic process of unknown origin. The tratment of choice is the surgical treatment: Corticosteroids may be also useful

1,027

[ 8120524, 21568724, 3287769, 22210556, 11014014 ]

What is the mechanism of action of eprotirome?

Eprotirome belongs to thyromimetics and has selective TRβ1 activity. It has shown to be effective in dyslipidemia by the lipid-lowering action of TH in the liver and also in obesity.

1,537

[ 24440706, 18447589, 20625286, 22542282, 20935564, 22784847, 24731671, 25172631, 23565368, 20220185, 23776891, 20872316 ]

Which type of variants can be called by the VarDict algorithm?

VarDict is a novel and versatile variant caller for both DNA- and RNA-sequencing data. It simultaneously calls SNV, MNV, InDels, complex and structural variants, expanding the detected genetic driver landscape of tumors. It performs local realignments on the fly for more accurate allele frequency estimation.

3,709

[ 27060149 ]

Name an lncRNA associated with dilated cardiomyopathy.

The lncRNA H19 is significantly upregulated in the myocardial tissue in dilated cardiomyopathy.

2,692

[ 28430627 ]

Autophagy is the process where a virus obtains nutrients from it's host, yes or no?

No, autophagy is important in cellular homeostasis for the cell survival mechanism and is involved apoptosis.

3,396

[ 24914338, 24779013, 30544615, 28889353, 29022289, 22475795, 28884441, 31803515 ]

Is CD99 encoded by MIC2 gene?

CD99 is a 32-kDa transmembrane glycoprotein that is encoded by the MIC2 gene

581

[ 10492040, 15359120, 10941840, 8399135, 11037347, 25007147, 22356523, 1867320, 21063743, 10782405, 24322504, 17725386, 10688843, 22020966, 9278313, 9623916, 23644663, 24158076, 15978751 ]

List polyubiquitin binding proteins involved in NF-kappaB signaling.

NEMO A20 ABIN-1 ABIN-2 optineurin p62

2,387

[ 23509369, 23989959, 18995839, 19285159 ]

What are the 3 antidotes for anticoagulant (anti-blood clotting) drugs, including factor Xa inhibitors, as of November 2017.

two potential reversal agents for oral direct factor Xa inhibitors (andexanet alfa and ciraparantag) are at various stages of clinical development. Idarucizumab, a reversal agent for the oral direct thrombin inhibitor dabigatran, was approved by FDA in October 2015.

2,729

[ 27626268, 27789605, 27895055 ]

Which are the characteristics of the Meier-Gorlin syndrome?

The Meier-Gorlin syndrome is a rare autosomal recessive disorder, characterized by the association of bilateral microtia, aplasia or hypoplasia of the patellae, and severe pre- and postnatal growth retardation.

752

[ 11477602, 21358631, 21358632, 25059018, 23144622, 23023959, 10213048, 14564153, 11807867, 7981855 ]

What imaging modalities have been listed as method of choice to diagnose CSF leak?

CT cisternography in the investigation of cerebrospinal fluid rhinorrhoea. CTC is an accurate, well-tolerated procedure and should be regarded as the method of choice for investigation of this condition. ...unenhanced (three-dimensional constructive interference in steady state (3D-CISS)...In conclusion, 3D-CISS is a non-invasive and reliable technique, and should be the first-choice method to localise CSF leak.

1,710

[ 19242563, 11109603, 8519147, 11331153, 19723768 ]

Where can we find the protein dermcidin?

Dermcidin is a secretes protein found mainly in sweat but it is also found in serum.

1,246

[ 23426625, 22448321, 24916439, 24828484, 24652391, 25347115, 22262861, 23626547, 24969620, 24562771, 25485461, 22588119, 25055737, 25271322, 22455996, 25330301, 24991806 ]

Are people with blood group O protected against severe Malaria?

It appears that individuals who are of blood-group O are relatively resistant to the severe disease caused by P. falciparum infection.

464

[ 17959777, 22771625, 23071435, 15814030, 22818742 ]

What is the effect of rHDL-apoE3 on endothelial cell migration?

rHDL-apoE3 has been shown to promote endothelial cell migration.

4,569

[ 34875308 ]

What is the indication for zolmitriptan?

Development of a novel zolmitriptan intracutaneous microneedle system (Qtrypta™) for the acute treatment of migraine

4,091

[ 18028032, 9660035, 10640260, 16575626, 31593739, 11200789, 12083998, 31889312, 9170337, 9071267, 32752932, 14642738, 15992000, 10473025, 11594437, 10210888, 9399012, 9399013, 14743270, 9725543, 9399017 ]

How many clinical trials for off-label drugs in neonates are cited in the literature.

There are no reports on clinical trials of off-label drugs in neonates. An analysis of Pediatric Investigation Plans submitted between 2007 and 2010 shows that neonates were included in the study of 4 products, but it is unknown if the trial drugs are off-label and if the trials are being conducted at all.

107

[ 20821198 ]

Which are the coactivators of the Yes-associated protein (yap)?

The Yap protein forms complex with Tead (TEA domain) transcription factors.

1,292

[ 16332960, 20439427, 25097035, 23380592, 23985334, 22632831 ]

Is cohesin linked to myeloid differentiation?

Yes. There has been a link found between cohesin and myeloid differentiation which may help explain the prevalence of cohesin mutations in human acute myeloid leukemia.

2,787

[ 30127433 ]

Please list symptoms of measles.

The leading symptoms of the disease are high fever that presents after an incubation period of 9-10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. The most commonly occuring satellite symptoms are conjunctivitis, coryza and cough.

2,865

[ 26613224, 29310585, 15230469, 27168928 ]

Gene silencing can be achieved by RNA interference (RNAi) in eukaryotic organisms. What is the name of the analogous process in prokaryotic organisms?

Bacteria have developed several defense mechanisms against bacteriophages over evolutionary time, but the concept of prokaryotic RNA interference mediated defense mechanism against phages and other invading genetic elements has emerged only recently. Clustered regularly interspaced short palindromic repeats (CRISPR) together with closely associated genes (cas genes) constitute the CASS system that is believed to provide a RNAi-like defense mechanism against bacteriophages within the host bacterium.

338

[ 19945378, 20109154, 23439366, 16545108, 21441598, 18971321, 19706170, 17537822 ]

Which hormone deficiency is implicated in the Costello syndrome ?

Growth hormone deficiency is implicated in Costello syndrome. Growth hormone therapy should be administered with caution due to possible severe side effects. Cortisol and sex hormone deficiencies were also implicated in Costello syndrome.

636

[ 19035362, 22752028, 15316966, 14564166, 15316968, 18483625, 20307337, 8168845, 22887473, 17551924, 19258709, 21438134, 16278907, 22821884, 15940703 ]

Does DDX54 play a role in DNA damage response?

Yes. DDX54, a candidate genotoxic stress responsive RNA helicase, regulates transcriptome dynamics during DNA damage response.

2,342

[ 28596291 ]

What is the function of HDAC proteins?

Histone deacetylases influence diverse cellular processes and may contribute to tumor development and progression by multiple mechanisms. Histone deacetylases prevent the relaxation of chromatin, and positively or negatively regulate transcription.

2,700

[ 10220385, 27668865, 23724067, 15050820, 22621256, 23088873, 19443688, 17767915, 27939885, 27345839, 17227860, 11602581, 26927903, 28078999, 10869435, 28930559 ]

What is pyroptosis?

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and IL-1β. Pyroptosis has been reported to be closely associated to some diseases like atherosclerosis and diabetic nephropathy. Recently, some studies found that pyroptosis can influence the proliferation, invasion and metastasis of tumor, which regulated by some non-coding RNAs and other molecules.

3,985

[ 31733200, 31756255, 31710896, 30917630 ]

What are the effects of ibrutinib on CART cell production?

CART cell generation in the presence of ibrutinib resulted in increased cell viability and expansion of CLL patient-derived CART cells. Furthermore, ibrutinib enriched CART cells with less-differentiated naïve-like phenotype and decreased expression of exhaustion markers including PD-1, TIM-3 and LAG-3. In addition, ibrutinib increased the cytokine release capacity of CLL patient-derived CART cells. In summary, BTK/ITK inhibition with ibrutinib during CART cell culture can improve yield and function of CLL patient-derived CART cell products.

4,382

[ 32683672, 32055000 ]

Which kinase is inhibited by the small molecule KN-93?

The calcium/calmodulin-dependent protein kinase-II (CaMK-II) is inhibited by the small molecule KN-93. KN-93 is a membrane-permeant calcium/calmodulin- dependent kinase II (CaMK-II)-selective inhibitor

119

[ 9596994, 11164895, 1662507, 21187407, 11248432, 10712242, 9864285, 16896952, 15569687, 11827960, 22290426, 17457979, 14749212, 15175389, 7690557, 8939965 ]

List human antibody isotypes.

IgA IgE IgG IgM IgD

3,783

[ 29684416, 29382466, 16157351, 29125655, 20050331 ]

What is the contribution of ultraconserved elements in Australasian smurf-weevils?

Ultraconserved elements (UCEs) resolve the phylogeny of Australasian smurf-weevils.

2,979

[ 29166661 ]

Which receptor is targeted by Spesolimab?

Spesolimab is a novel anti-interleukin-36 receptor antibody.

4,599

[ 33661508, 33919434, 34085329, 33785490, 34678325, 34626330, 32884319 ]

What is Path2PPI?

Path2PPI is an R package to identify protein-protein interaction (PPI) networks for fully sequenced organisms for which nearly none PPI are known. Path2PPI predicts PPI networks based on sets of proteins from well-established model organisms, providing an intuitive visualization and usability. It can be used to combine and transfer information of a certain pathway or biological process from several reference organisms to one target organism.

1,837

[ 26733452 ]

Do genes with monoallelic expression contribute proportionally to genetic diversity in humans?

No, genes with monoallelic expression contribute disproportionately to genetic diversity in humans.

3,706

[ 26808112 ]

Which organs are mostly affected in Systemic Lupus Erythematosus (SLE)?

In systemic lupus erythematosus (SLE), brain and kidney are the most frequently affected organs. The heart is one of the most frequently affected organs in SLE. Skin is one of the most commonly affected organs in SLE. Other affected organs in SLE-AAC included hematologic system (11, 84.6%), followed by mucocutaneous (seven, 53.8%), musculoskeletal (seven, 53.8%) and neuropsychiatric (two, 15.4%) systems.

2,767

[ 24268009, 25186992, 7588946, 28355987, 19758166, 21767292 ]

How does trimetazidine affect intracellular kinase signaling in the heart?

Trimetazidine activates AMPK in diabetic myocardium. Trimetazidine when administered before reperfusion results in activation of p38 mitogen-activated protein kinase and Akt signaling. Trimetazidine when administered during reperfusion does not affect p38MAPK and JNK activation.

441

[ 19546072, 20167841, 20383170, 15616764 ]

Is imatinib an antidepressant drug?

No. Imatinib is a tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably Chronic myelogenous leukemia (CML) and Gastrointestinal stromal tumor (GIST).

1,653

[ 15966213, 23394826, 21087500, 20726677, 19628568, 22484890, 22593820, 22110503, 22135725, 22035758, 21073206, 17554495, 18506179, 20676553, 20442314, 22460758, 16566359, 21938530, 16403813, 22487918, 22831984, 21607924, 22678007, 20407930, 19110398 ]

Which kinase does PD98059 inhibit?

PD98059 is a specific, reversible MEK inhibitor.

4,372

[ 32378175 ]

Is muscle regeneration possible in mdx mice with the use of induced mesenchymal stem cells?

Purified induced mesenchymal stem cells (iMSCs) display fibroblast-like morphology, form three-dimensional spheroid structures, express characteristic mesenchymal stem cell surface markers such as CD29, CD33, CD73, CD90, and CD105, and are capable of differentiating into adipogenic, osteogenic, and chondrogenic lineages. Transplantation of iMSC cells to tibialis anterior skeletal muscle tissue in mdx mice lowers oxidative damage, and restores the expression levels of normal dystrophin, leading to skeletal muscle regeneration.

1,203

[ 17999592, 25102299 ]

What is the relationship between RUNX1T1 and FTO?

FTO controls exonic splicing of adipogenic regulatory factor RUNX1T1 by regulating m6A levels around splice sites and thereby modulates differentiation. The effect of FTO on adipogenesis appears to be mediated via enhanced expression of the pro-adipogenic short isoform of RUNX1T1.

4,268

[ 25881961, 25412662 ]

Which is the execution time (complexity) of the Smith-Waterman algorithm for the alignment of two sequences

The complexity of the Smith-Waterman dynamic programming algorithm is quadratic, that is, it runs in time proportional to the product of lengths of the sequences being aligned.

997

[ 16522182, 14668231, 20370891, 21714130, 1774068, 11301301, 9021270, 12804086 ]

Is Verubecestat effective for Alzheimer's Disease?

No. Verubecestat did not reduce cognitive or functional decline in patients with mild-to-moderate Alzheimer's disease and was associated with treatment-related adverse events.

3,680

[ 28749667, 30347431, 30970186, 29719179, 31387606, 31423903 ]

Are nucleosomes positioned at DNA replication origins?

No, origins of replication occur in nucleosome-free regions in both budding yeast and Drosophila. Open chromatin domains, characterized by nucleosome depletion, are preferentially permissive for replication.

1,370

[ 20351051, 1587867, 21148149, 19463783 ]

Does addition of valproic acid improve survival of patients with diffuse intrinsic pontine glioma?

No. Addition of valproic acid and bevacizumab to radiation was well tolerated but did not appear to improve survival in children with diffuse intrinsic pontine glioma.

4,409

[ 24293221, 32285998 ]

What is the mode of inheritance of Wilson's disease?

Wilson's disease (WD) is an autosomal recessive disorder.

21

[ 8186659, 16932613, 838566, 6620327, 12152840, 22610954, 2724779, 8615372, 1940586, 6109943, 759736, 14580665, 20662462, 1248830 ]

What is known about depression in caregivers of brain tumor patients?

Depression is common affecting up to 40% of caregivers of brain tumor patients. Depression is associated with poor quality of life of caregivers of brain tumor patients. Greater anxiety, patients’ emotional distress, economic hardship, lower caregivers’ age, lower income, less social support and lower patient functioning were associated with more caregivers’ depressive symptoms. Reports of caregiver depressive symptoms were lower when paired with higher reports of spirituality. It is important to monitor and treat caregiver's depression.

1,209

[ 18329220, 16532486, 23187335, 24152975, 21994513, 22307475, 12605978, 17760798, 19159080, 23615145, 21968946, 23438646, 18061752, 23104453, 23384776, 18481737, 22585179, 23633116, 23989499 ]

What is AZD0530 an inhibitor of?

AZD0530 is a highly selective, dual Src/Abl kinase inhibitor.

3,696

[ 22623106 ]

What type of cancers and inherited diseases have been associated to mutations in the Notch pathway?

So far, mutations in Notch and other components of its signaling pathway have been implicated in an array of human diseases (T-cell leukemia and other cancers, Multiple Sclerosis, CADASIL, Alagille Syndrome, Spondylocostal Dysostosis), but more pathologies are likely to be associated with Notch in the future due to its network complexity.

1,332

[ 22891273, 15712272, 22488849, 18775957, 19289631, 22156581, 11180599, 22210878, 20823234, 9585603, 21562564, 16773578, 21196490, 17584081, 23095891, 23359070, 12497640, 20087400, 9207788, 22974708 ]

Which is the causative agent of malaria?

Four Plasmodium species commonly infect humans (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale). Plasmodium falciparum infects about 5-10% of the world human population per year and it is the causative agent of the most severe and lethal form of malaria. P. falciparum causes fatal cerebral malaria and is responsible for most deaths, particularly in pregnant women and children under the age of five. P. falciparum is transmitted to the human host by Anopheles mosquitoes and is the most tremendous malaria vector in sub-Saharan Africa. Plasmodium vivax is the causative agent of benign malaria in more temperate climates of the world. Plasmodium gallinaceum is the main bird malaria causative agent and Plasmodium yoelli is the principle rodent malaria agent.

1,539

[ 21209090, 15265796, 19706885, 15701514, 2067470, 12139027, 1648659, 15463447, 22563351, 23088152, 2067482, 21989409, 23483940, 22592550, 22095915, 8300589, 15073329, 23046708, 18672695, 8631352, 16458301, 9927744, 19801158, 22359643, 9514077, 11085920, 11115107, 22341220, 12930149, 19666023, 15339111, 20610151, 8816746, 15117937, 23484017, 23405174, 22222968, 19706490, 22028927, 22990975, 19038338, 12626578, 21601941, 19380379, 21771420, 11796125, 19779742, 19666593, 21698217, 21904052, 12929205, 14514358, 19020475, 20500669, 19013823, 15246528, 16203971, 15003844, 14638789, 20702404, 3911876, 22628552, 11839179, 18295508, 23349974, 22019287, 22524128, 7715553, 23382752, 22507744, 18221799, 22819049, 18611947, 11687659, 19184366, 15950069, 22543099, 10585859, 17868038, 20078859, 20635416, 1474844, 16042788, 22057268, 6728514, 18082626, 16222020, 23326533, 22216006, 19267910, 18563912, 9874251, 11504465, 1813841, 18628947, 17024857, 2191201, 14556002, 21329764, 21570407, 4047719, 10703207, 21297002, 19768685, 18164079, 18522993, 20353400, 18925948, 21670272, 14627712, 11087748, 22929299, 15703443, 18989463, 23293353, 12125103, 20034997, 18248630, 11559352, 10744765, 21866942, 14609342, 15878595, 6760901, 15147974, 21206476, 23342028, 15293910, 23246819, 15033330, 3011062, 17822713, 19931645 ]

Does burning mouth syndrome preferentially affect post-mepopausal women?

BMS is observed principally in middle-aged patients and postmenopausal women BMS mostly affects elderly citizens, especially postmenopausal women with prevalence up to 12-18%.

249

[ 7838464, 6589575, 9844361, 17541900, 21685517, 16142094, 15055637, 17452954, 18305436, 9237148, 3476895, 18278306, 8469539, 21418666, 23772971, 18985004, 12618668, 12907696, 7629360, 11441716, 10431669, 12764983, 21528120, 20230455, 20440632, 23050296, 21903545, 20597947, 11871678, 10446526, 22030140, 15195716, 16905808, 19450321, 18625105, 8725589, 8170453, 22612823, 23201368, 2700889, 19689438, 17439072, 20038880, 17967714, 20701667, 19658340, 18558051, 24096230, 15024358, 16637799, 12017897, 11603307, 17849966, 10478959, 23787507, 15911160 ]

Which is the most known bacterium responsible for botulism (sausage-poisoning)?

Botulism is a severe neuroparalytic disease caused by botulinum neurotoxin (BoNT), and affects humans, all warm-blooded animals, birds, and some fishes. Botulinum toxin is produced under anaerobic conditions by the bacterium Clostridium botulinum, which is the most known etiological agent of the disease, and some other clostridia, and is one of the most dangerous toxin in the world.

133

[ 24961027, 21171846, 21975066, 24252701, 20961439, 18388640, 15839401, 23239346, 23523511, 24253240, 23421373, 24252222, 17458494, 19573697, 24206405, 21747146, 11153358, 24246230, 23971804, 23971806, 23971808, 15027048, 20569065, 21130733, 24997242, 16080379, 23025151 ]

Is autophagy the process where bacteria ingest viral particles?

Autophagy, a cellular degradation process

2,159

[ 24198400, 21946213, 27812870, 23121192, 24906121, 27814601, 27027951, 24384599, 21175768, 23388380 ]

What are the side effects during statins administration in patients with atherosclerosis?

The side effects during statins administration in patients with atherosclerosis are: 1) Myopathy 2) Transaminase elevations 3) Diabetes mellitus 4) Renal and neurologic adverse effects.

1,938

[ 22913216, 21796961, 26575138, 24788803, 25936326, 27878791, 25644328, 12891851, 19039148, 21972203, 24840269, 17042673, 24601937, 18585718, 25678839, 23299641, 21267417, 26490078 ]

Can radiosurgery be used for the DNET tumors?

Yes, radiosurgery is used for the DNET (Dysembryoplastic neuroepithelial) tumors. However, the level of evidence is limited.

3,978

[ 28868186, 17240596 ]

Which tool has been developed to identify the glycan shielding of glycosylated proteins?

GLYCO (GLYcan COverage) is an in silico approach to quantify the glycan shielding of a protein surface. The software provides insights into glycan-dense/sparse regions of the entire protein surface or a subset of the protein surface. GLYCO calculates glycan shielding from a single coordinate file or from multiple coordinate files, for instance, as obtained from molecular dynamics simulations or by nuclear magnetic resonance spectroscopy structure determination, enabling analysis of glycan dynamics.

4,684

[ 34864901 ]

Is the Fluzone intradermal and the Fluzone intradermal quadrivalent vaccine produced by different companies?

No, the Fluzone Intradermal vaccine and the Fluzone Intradermal Quadrivalent vaccine are produced by Sanofi Pasteur.

3,245

[ 27457797 ]

Which R/bioconductor package exists for discovery of intergenic transcripts?

To increase the power of transcript discovery from large collection of RNA-seq data sets, a novel '1-Step' approach named pooling RNA-Seq and Assembling Models (PRAM) has been developed that build transcript models from pooled RNA- sequencing data sets. PRAM is implemented as an R/Bioconductor package.

4,140

[ 32958497 ]

Is Ameloblastoma (AB) a common benign tumor occurring in the brain?

Ameloblastoma (AM) is a slow growing and aggressive benign tumor with an odontogenic epithelial origin arising from the mandible or maxilla.

4,667

[ 20051072, 34508164, 27721617, 17170964, 28212886, 32698263, 14970780, 25298718, 29274152, 19995435, 28187692, 27099699, 10895162, 32484411, 26261564, 21717310, 28191811, 30420932, 33394372, 21968082, 30126803, 32659412, 25567699, 26925653, 26015700, 1569364, 34599642, 23986011, 31674718, 34510060, 29747056, 21371124, 31990904, 34594553, 30196986, 34511355, 25206141, 27435007 ]

List non-surgical treatment modalities that are included in the Stupp protocol.

Radiotherapy and chemotherapy are non-surgical treatment modalities that are included in the Stupp protocol. This protocol is widely used for treatment of glioblastoma.

1,591

[ 18808066, 25434389, 20428822, 22141608, 24600235, 22359215, 23588276, 22464950, 24287680, 21156036, 21344976, 24111708, 23453151, 25201633, 20045159, 23254891, 20870254, 23535992, 24518393 ]

What organism causes woolsorter's disease

Woolsorter's disease is caused by the same organism as Anthrax, bacillus Anthrax.

1,960

[ 18959192, 15486181 ]

The Shingrix vaccine is used to prevent what disease?

Shingrix is a 4-component vaccine against capsular herpes zoster (4CZV), which has recently been licensed in Europe, Canada and Australia.

4,073

[ 31423396, 31258310, 33163688, 31400911, 31399377, 32999027, 30145235, 30370455, 32606264, 33067034, 32862397 ]

How is myotonic dystrophy inherited?

Myotonic dystrophy (DM) is a heterogeneous neuromuscular disease with an autosomal dominant pattern of inheritance.

613

[ 8154209, 18228241, 12577208, 22332444, 12970845 ]

What is generic name of drug Adempas?

Riociguat is generic name of drug Adempas. It is a soluble guanylate cyclase stimulator that was approved for the treatment of patients with chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.

558

[ 24391396, 24218053, 25395817, 25352393, 24524094 ]

What drug cures hepatitis C?

Sofosbuvir-based therapy cures hepatitis C virus infection

2,629

[ 26085900, 26209383 ]

Austrian syndrome is a rare entity characterized by Osler's triad. Please list the 3 components of Osler's triad.

Austrian syndrome, which is also known as Osler's triad, is a rare aggressive pathology consisting of pneumonia, endocarditis, and meningitis caused by Streptococcus pneumoniae

4,467

[ 31259104, 34710311, 32923368, 29967896, 30254807, 28266699, 14600140, 31659532, 17599001, 22030703, 29848535, 32426357, 18635383, 30880376, 31300377, 19886075, 25218621 ]

Is SMOC2 expressed during wound healing?

Yes, SMOC2 response to wounding.

4,236

[ 34876240, 33710643, 32908163, 32355542 ]

In which nuclear compartments is heterochromatin located?

This compartment localizes into three main regions: the peripheral heterochromatin, perinucleolar heterochromatin, and pericentromeric heterochromatin. Silencing appears to be associated with histone H3 lysine 9 trimethylation (H3K9me3), DNA methylation and the localization of the silenced gene to a specific nuclear compartment enriched in these modification

982

[ 12432450, 22251972, 16254244, 23834025, 20026667, 21283637, 19889207, 15564378 ]

Which methyl-CpG-binding protein when mutant becomes the hallmark for Rett syndrome?

Rett syndrome (RTT) was shown to be caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene, with molecular studies identifying MECP2 mutations in up to 80% of classic RTT patients. MECP2 protein was found to assist in the transcriptional silencing process via DNA methylation. We therefore hypothesize that disruption of this gene alters the normal developmental expression of various other genes, some of which must account for the peculiar neurologic phenotype of RTT.

479

[ 22138506, 22302819, 18534925, 11180222 ]

Do Parkinson's disease patients experience stridor?

Yes. Stridor has been described in Parkinon's disease patients. Stridor has been linked to deep brain stimulation and L-Dopa medication use. However, stridor was shown to be more common in multiple system atrophy patients.

1,173

[ 14703107, 12023429, 19010952, 20003593, 6622345, 16575624, 10391085, 19628429, 8353712, 21819188, 7651445, 7785431, 20205147, 12884831 ]

What is the purpose of Macropinocytosis?

Macropinocytosis is an endocytic process, which involves the engulfment of extra-cellular content in vesicles known as macropinosomes.

4,573

[ 34755081, 27647881, 30333835, 14732047, 30617109, 29085336, 27352861, 32745890, 31924779, 25096879, 11029048, 17760832, 10321993, 30725454, 10678991, 30966999, 30967003, 30400219, 30967006, 30967007, 30967008, 30967009, 33520357, 32756454, 27503856, 11890548, 15533943 ]

Which are the main histone modifications associated with enhancers?

Histone 3 lysine 4 mono- (H3K4me1) and di-methylation (H3K4me2) are the main post-transcriptional histone modifications related to enhancer activity.

1,578

[ 20621055, 19021773, 22270183 ]

Can Preimplantation Genetic Diagnosis (PGD) be used for gender selection?

Preimplantation Genetic Diagnosis can be used for gender selection.

1,585

[ 19294755, 19891844, 18222917, 12470342, 20638568, 9329835, 19251775, 18829009, 20102489, 18667646, 12615807 ]

List diseases that are repeat expansion disorders (REDs).

The expansion of Short tandem repeats underlies the pathogenesis of multiple neurological disorders, including Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal dementia, fragile X-associated tremor/ataxia syndrome, and myotonic dystrophies, known as repeat expansion disorders (REDs).

4,596

[ 25726753, 32695777, 8908515, 32589669, 29325606, 26420841, 9302257, 19710035, 25886163, 14526165, 8900536, 32619224, 10766906, 34502075, 34054431 ]

List biomarkers for sepsis.

HCK, PRKCD, SIRPA, DOK3, ITGAM, LTB4R, MAPK14, MALT1, NLRC3, LCK C-Reactive Protein (CRP), Procalcitonin (PCT) and Interleukin 6 (IL-6) sTM

4,474

[ 33274532, 34524647, 33140076, 34517744, 34551574, 32705879, 31537145, 34634653 ]