source
stringclasses 7
values | source_url
stringlengths 33
155
| persistent_id
stringlengths 7
7
| title
stringlengths 3
145
| cui
stringlengths 8
10
⌀ | idx
int64 0
31.8k
| text
stringlengths 31
5.37k
| vector
sequence |
|---|---|---|---|---|---|---|---|
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. , and many manifest both regional lipomatous overgrowth and lipoatrophy. Persons with PS do not have the typical ovoid, encapsulated lipomas common in the elderly and so the term "lipoma" is technically incorrect, but in wide usage. Fatty infiltration of the myocardium, particularly the intraventicular septum, has been observed in a number of children and adults with PS with no functional consequences .Vascular malformations. Many individuals with PS have cutaneous capillary malformations and prominent venous patterning or varicosities; large and complex vascular malformations affect some individuals. Vascular malformations are commonly recognized in the first months of life and are generally stable over time . Lymphatic vascular malformations can arise in any tissue that normally includes such vessels. These can be progressive and are often present with areas of lipomatous overgrowth, which can complicate surgical approaches to lipomas.The most urgent and life-threatening complication of PS can be deep vein thrombosis (DVT) and pulmonary embolism (PE) . Individuals with | [
-0.01109218504279852,
-0.014942296780645847,
-0.10632909089326859,
-0.10059527307748795,
0.0778447836637497,
-0.08150328695774078,
-0.00548126082867384,
-0.0693260133266449,
-0.09140359610319138,
-0.02480405569076538,
0.2142976075410843,
0.09770780801773071,
0.09462599456310272,
0.042280666530132294,
-0.15229545533657074,
0.17361870408058167,
-0.19203133881092072,
-0.06816023588180542,
0.04568039998412132,
-0.03377722203731537,
-0.02451881393790245,
-0.19127695262432098,
0.002443501492962241,
0.13837288320064545,
0.019552281126379967,
-0.010871046222746372,
0.3180983364582062,
0.305310994386673,
0.0022171686869114637,
0.005858642049133778,
0.00474519282579422,
-0.06520779430866241,
0.021348323673009872,
-0.3444923758506775,
0.12986359000205994,
-0.23753614723682404,
-0.2172006219625473,
0.16993765532970428,
0.09772049635648727,
-0.016405947506427765,
-0.13375113904476166,
0.06782321631908417,
-0.04702312871813774,
-0.10638964921236038,
0.1928211897611618,
-0.07617081701755524,
0.0745471864938736,
0.19415561854839325,
-0.01898767612874508,
0.29075759649276733,
0.17122170329093933,
-0.06041032075881958,
0.1171279102563858,
0.022768458351492882,
0.14437460899353027,
-0.10849641263484955,
0.045187294483184814,
-0.06958197802305222,
-0.25363942980766296,
0.053330302238464355,
0.23462142050266266,
-0.05840478837490082,
0.18598125874996185,
-0.4322430491447449,
0.008321722038090229,
-0.019437331706285477,
0.03640095144510269,
0.11247056722640991,
0.13446161150932312,
0.08409301191568375,
0.42787936329841614,
-0.2191125899553299,
-0.04055707901716232,
-0.03082888573408127,
0.06308078020811081,
-0.01822770945727825,
0.06700735539197922,
-0.2215336412191391,
-0.15349039435386658,
-0.22553841769695282,
0.08116068691015244,
-0.11230957508087158,
-0.05731877312064171,
0.018540456891059875,
-0.27478212118148804,
-0.10304637998342514,
-0.02376442402601242,
0.014107892289757729,
-0.09242194145917892,
0.03946288675069809,
0.04134882241487503,
-0.03004462458193302,
-0.004655654542148113,
0.1598130315542221,
0.1514686644077301,
-0.16137774288654327,
-0.07614148408174515,
0.027852024883031845,
-0.1458108127117157,
0.12515957653522491,
0.0884852260351181,
0.15665362775325775,
-0.05352454259991646,
-0.0046116067096591,
0.0009874928509816527,
-0.09593822062015533,
-0.17877189815044403,
0.011116709560155869,
0.16547104716300964,
0.13363656401634216,
-0.12830400466918945,
-0.12046083807945251,
0.026932241395115852,
-0.27201682329177856,
-0.3006170392036438,
-0.055937886238098145,
0.13454768061637878,
-0.022087186574935913,
-0.03231783211231232,
-0.15262503921985626,
-0.02327253855764866,
-0.04340948536992073,
0.027438711374998093,
0.03082127496600151,
0.15948906540870667,
0.02049696445465088,
0.20476321876049042,
-0.06415753066539764,
0.05685121566057205,
-0.07734311372041702,
0.17561261355876923,
-0.21439172327518463,
0.012361643835902214,
-0.20378154516220093,
0.06698185205459595,
0.0723811537027359,
-0.09085645526647568,
-0.07947982102632523,
0.09859639406204224,
-0.020447595044970512,
0.24819765985012054,
0.03815259039402008,
0.2973432242870331,
0.12413863837718964,
0.0010128222638741136,
-0.001412749639712274,
0.21906185150146484,
0.20287063717842102,
0.25621068477630615,
-0.020872879773378372,
0.3063734173774719,
-0.2012825459241867,
0.1524069458246231,
0.024366937577724457,
-0.06393341720104218,
-0.014877439476549625,
-0.027868930250406265,
0.015967167913913727,
-0.17975306510925293,
-0.08952794224023819,
-0.00266528083011508,
-0.19334375858306885,
0.017162451520562172,
-0.029021726921200752,
-0.1356656700372696,
0.2403707653284073,
-0.007757703773677349,
-0.08044600486755371,
0.11818570643663406,
0.03757397457957268,
-0.09929680079221725,
0.06711243093013763,
-0.1424262374639511,
-0.07504669576883316,
-0.0880817323923111,
-0.015722453594207764,
0.04032206907868385,
0.07758042216300964,
-0.16126051545143127,
0.039909545332193375,
0.166262686252594,
-0.0037649928126484156,
-0.15665774047374725,
-0.1984066516160965,
-0.09074074774980545,
-0.09934666752815247,
0.0460415780544281,
0.21156907081604004,
-0.16704513132572174,
0.051346082240343094,
0.19549560546875,
-0.001069052261300385,
-0.03530120477080345,
0.10730627924203873,
-0.09488892555236816,
-0.1741769164800644,
-0.10453548282384872,
-0.16263842582702637,
0.043137263506650925,
-0.0018870056373998523,
0.07882245630025864,
-0.004910933785140514,
0.10335694253444672,
-0.0237906351685524,
0.2011377364397049,
0.05408046767115593,
0.03264312446117401,
-0.18346019089221954,
0.03471214324235916,
0.04276087135076523,
0.0274919793009758,
0.23934820294380188,
-0.06271453946828842,
-0.10058993101119995,
0.14027932286262512,
-0.009535085409879684,
-0.19972431659698486,
-0.10059572011232376,
0.021780380979180336,
0.1563209891319275,
-0.2026347666978836,
0.19829225540161133,
-0.14639632403850555,
-0.28809794783592224,
-0.349284827709198,
0.11009383946657181,
-0.04989978298544884,
-0.021985070779919624,
-0.042657673358917236,
0.12911857664585114,
-0.054373566061258316,
0.042655907571315765,
0.10042021423578262,
0.00759974354878068,
-0.0991530567407608,
-0.28754234313964844,
-0.19436898827552795,
0.3257352411746979,
-0.011296465992927551,
0.14029869437217712,
-0.12635838985443115,
0.005216604098677635,
-0.05218476802110672,
-0.13647371530532837,
-0.1032520979642868,
0.048412974923849106,
0.059283118695020676,
0.12146706134080887,
-0.06087002530694008,
-0.024751272052526474,
0.0340600423514843,
-0.17647485435009003,
0.14163362979888916,
0.08126058429479599,
-0.20818041265010834,
-0.07593617588281631,
0.11886084824800491,
-0.08721394836902618,
0.06450293958187103,
0.06201628968119621,
0.11749695986509323,
0.04887213930487633,
0.21856935322284698,
-0.15677359700202942,
-0.22871413826942444,
-0.16347408294677734,
-0.17653264105319977,
0.10536078363656998,
-0.12733815610408783,
-0.2603900730609894,
-0.18084895610809326,
0.1856922209262848,
0.16580863296985626,
0.00014144930173642933,
0.03188672661781311,
0.18566389381885529,
0.03524473309516907,
0.11551868170499802,
0.16256025433540344,
0.06749793142080307,
0.08558977395296097,
0.07372847944498062,
-0.03772897273302078,
-0.0074404459446668625,
0.35554689168930054,
0.08857709169387817,
-0.27533674240112305,
0.18569718301296234,
0.0652892217040062,
-0.11928395181894302,
0.10728781670331955,
0.10965809971094131,
-0.04108572378754616,
-0.011479520238935947,
0.156289204955101,
0.14066891372203827,
-0.22417773306369781,
-0.07859906554222107,
0.07513399422168732,
-0.05412646755576134,
-0.00019424919446464628,
0.26777616143226624,
-0.22707459330558777,
0.08729953318834305,
0.1227906197309494,
-0.11388948559761047,
0.07719594240188599,
0.032672423869371414,
-0.06294284015893936,
-0.1469976305961609,
-0.22717683017253876,
0.03687647357583046,
-0.002397501142695546,
0.02080848440527916,
-0.06796693056821823,
0.0012950556119903922,
-0.003689843462780118,
-0.01870048977434635,
0.19543777406215668,
0.022114120423793793,
-0.005048774648457766,
-0.022876903414726257,
0.10290220379829407,
0.10544580966234207,
0.06966972351074219,
-0.02852783538401127,
0.06956347823143005,
0.0953601822257042,
-0.029285941272974014,
0.03425725921988487,
0.08114743232727051,
0.007620690390467644,
-0.20830176770687103,
-0.13607938587665558,
0.008004832081496716,
0.06171407923102379,
0.08313235640525818,
-0.08710070699453354,
0.07600455731153488,
-0.10474647581577301,
-0.08891326934099197,
-0.25609666109085083,
0.05723194032907486,
-0.10014690458774567,
0.06891260296106339,
0.18244624137878418,
0.09966618567705154,
0.12813514471054077,
-0.013109361752867699,
-0.17276814579963684,
-0.059751227498054504,
-0.1705659031867981,
0.0240399781614542,
-0.22471340000629425,
0.06583191454410553,
0.05389736220240593,
0.030343087390065193,
0.07641039043664932,
-0.08072921633720398,
0.0669429823756218,
-0.15589967370033264,
-0.017593415454030037,
-0.03962026536464691,
-0.14431816339492798,
-0.045560818165540695,
0.08997318148612976,
-0.10243725031614304,
0.0025972987059503794,
0.2706662714481354,
-0.0444338358938694,
0.3603094518184662,
0.20134195685386658,
-0.08585783839225769,
-0.1809585988521576,
-0.01983022317290306,
0.1346542090177536,
-0.2037583291530609,
0.0035445638932287693,
-0.12018723785877228,
-0.14159314334392548,
-0.15131346881389618,
0.13314127922058105,
0.15552791953086853,
-0.028134066611528397,
-0.013280828483402729,
0.03262036293745041,
-0.3782559335231781,
0.11332058161497116,
-0.07054869830608368,
-0.17017972469329834,
0.2214701622724533,
0.0812099277973175,
0.04048853740096092,
0.2704868018627167,
-0.00889790803194046,
0.11244232207536697,
0.1267085075378418,
-0.03269166871905327,
-0.2620847821235657,
0.02235604077577591,
-0.11748381704092026,
-0.022189587354660034,
0.3115410804748535,
0.24466994404792786,
0.22723129391670227,
0.011467701755464077,
-0.13168936967849731,
0.06330272555351257,
-0.04847072437405586,
0.3732750415802002,
-0.14811983704566956,
-0.036692071706056595,
0.052031099796295166,
-0.04748324304819107,
-0.28141161799430847,
-0.14599747955799103,
-0.06358033418655396,
-0.060253843665122986,
0.11505478620529175,
-0.13758854568004608,
0.04185287654399872,
-0.12399197369813919,
0.16498471796512604,
0.014314836822450161,
-0.19997826218605042,
0.06871052086353302,
-0.04138379171490669,
0.08176684379577637,
-0.06226634234189987,
0.23081029951572418,
0.30850058794021606,
-0.07377893477678299,
-0.20298972725868225,
0.07585974037647247,
0.21999627351760864,
0.02287258766591549,
-0.00325540523044765,
0.20314760506153107,
0.16245640814304352,
-0.04713655635714531,
0.34027719497680664,
0.08733922988176346,
0.13325351476669312,
0.08278828114271164,
-0.048002827912569046,
0.08340134471654892,
0.06412861496210098,
0.08421836793422699,
-0.0707131177186966,
0.17704427242279053,
-0.058930329978466034,
0.08920616656541824,
0.09870085120201111,
0.010918623767793179,
0.2356318086385727,
0.20607809722423553,
-0.19107936322689056,
0.0655737817287445,
-0.12119884788990021,
0.16232088208198547,
0.01555397268384695,
0.14451593160629272,
0.20280425250530243,
0.03398462384939194,
-0.07321776449680328,
-0.001867503859102726,
-0.34004905819892883,
0.04694106802344322,
0.05289636179804802,
0.03966909274458885,
0.06724756211042404,
-0.009934949688613415,
0.031484685838222504,
-0.04517054557800293,
-0.007745941635221243,
0.06673862040042877,
-0.20119453966617584,
0.14347855746746063,
-0.23259861767292023,
0.12267753481864929,
0.2205176055431366,
0.0847010463476181,
-0.02520555444061756,
-0.22068729996681213,
0.024020101875066757,
0.2187453955411911,
0.06510529667139053,
-0.09492232650518417,
0.3514717221260071,
0.009431751444935799,
0.12298256158828735,
-0.009814186953008175,
0.10504776984453201,
0.36808016896247864,
0.0643695667386055,
-0.019619235768914223,
0.16087333858013153,
-0.02469349279999733,
-0.1401100605726242,
-0.1402752548456192,
-0.08313608914613724,
0.027674425393342972,
0.008001536130905151,
0.013236727565526962,
0.03202405571937561,
0.014108704403042793,
-0.04155081510543823,
-0.2699371874332428,
-0.09320789575576782,
0.09810031205415726,
-0.09674029797315598,
-0.18616262078285217,
0.09555608034133911,
-0.07667072862386703,
0.03683311864733696,
0.0832783579826355,
-0.10305361449718475,
0.21205399930477142,
0.1426728367805481,
-0.06021153926849365,
-0.046068936586380005,
-0.021517032757401466,
0.10923679918050766,
0.07052231580018997,
-0.16895021498203278,
-0.06463660299777985,
-0.16830645501613617,
0.2823278605937958,
-0.10085694491863251,
0.004168866667896509,
-0.14198456704616547,
0.13078346848487854,
0.17463791370391846,
0.07945668697357178,
0.11081336438655853,
0.011530013754963875,
0.05214916169643402,
-0.1456282138824463,
-0.020739221945405006,
0.13824203610420227,
-0.009897525422275066,
0.13664817810058594,
0.002563616493716836,
0.1594230681657791,
-0.054820261895656586,
0.1531907469034195,
0.2096996158361435,
0.05800853669643402,
-0.006755505688488483,
0.29911619424819946,
0.14579960703849792,
-0.03846487030386925,
-0.02201046794652939,
-0.10532570630311966,
-0.11747139692306519,
-0.030053813010454178,
0.1725749522447586,
0.0638062059879303,
0.06129849702119827,
0.20200997591018677,
-0.22910155355930328,
0.08453723043203354,
-0.0535411573946476,
0.060961633920669556,
0.02820098213851452,
0.23884011805057526,
0.39463263750076294,
-0.057737935334444046,
0.03491540998220444,
-0.04978037253022194,
0.007515471428632736,
-0.16628222167491913,
0.11850422620773315,
-0.10728578269481659,
-0.2578074336051941,
-0.011761493980884552,
-0.20420949161052704,
-0.18540987372398376,
-0.11854613572359085,
0.17131026089191437,
0.09277065098285675,
-0.2803209125995636,
-0.18103374540805817,
-0.1584150642156601,
0.10220251977443695,
0.11517970263957977,
-0.037859927862882614,
0.20605754852294922,
0.25344082713127136,
0.11534832417964935,
-0.20477904379367828,
-0.1938379406929016,
0.06995153427124023,
-0.012438429519534111,
0.06565655022859573,
-0.06307951360940933,
-0.012069256976246834,
-0.032344136387109756,
0.03306924179196358,
0.02560579590499401,
0.1041988953948021,
0.027761312201619148,
-0.09384214878082275,
-0.24213813245296478,
-0.21282267570495605,
0.08377016335725784,
0.16574859619140625,
-0.1986391544342041,
0.26607099175453186,
0.024579167366027832,
-0.12170576304197311,
-0.0991557240486145,
0.14242590963840485,
-0.00248964736238122,
0.2385265827178955,
-0.2766784727573395,
0.05339699611067772,
-0.10205712169408798,
0.21525803208351135,
-0.01309129036962986,
0.4489629864692688,
0.10317375510931015,
0.18952317535877228,
-0.08573073893785477,
-0.08082970976829529,
0.21049770712852478,
-0.17066526412963867,
0.02045563980937004,
0.15545755624771118,
-0.040752388536930084,
0.033659763634204865,
-0.1376013606786728,
0.009280222468078136,
0.14809992909431458,
-0.028061872348189354,
0.19333416223526,
0.09883708506822586,
-0.22415919601917267,
0.0050450400449335575,
-0.09384182095527649,
-0.012899298220872879,
0.07622045278549194,
0.024633964523673058,
0.24794220924377441,
-0.18002237379550934,
0.20553989708423615,
-0.03283568471670151,
-0.08390989154577255,
-0.0849829688668251,
-0.3815387189388275,
-0.0386064350605011,
0.1487496942281723,
0.10027360916137695,
0.09832879155874252,
0.07349162548780441,
-0.017037060111761093,
0.17742584645748138,
-0.14758165180683136,
-0.037160102277994156,
0.0940483808517456,
-0.21724215149879456,
-0.11898595094680786,
-0.14605404436588287,
0.00031632810714654624,
0.07610107958316803,
0.11289787292480469,
0.10358216613531113,
0.16176915168762207,
-0.25422772765159607,
-0.16176512837409973,
-0.2372182160615921,
0.13502606749534607,
0.19556042551994324,
0.020857632160186768,
-0.09492615610361099,
0.11785270273685455,
0.01636148989200592,
-0.15940731763839722,
0.09139104932546616,
0.33390048146247864,
-0.025877805426716805,
-0.39845481514930725,
-0.13360251486301422,
-0.2309451848268509,
0.015588992275297642,
-0.11057817190885544,
-0.08275316655635834,
0.016878440976142883,
0.26030483841896057,
-0.1483263522386551,
0.008978690020740032,
-0.03458866477012634,
0.02070038951933384,
0.1108466163277626,
-0.03312939405441284,
-0.26942765712738037,
0.25567615032196045,
-0.012971893884241581,
-0.0005817279452458024,
0.04819314554333687,
-0.08365792036056519,
0.04123694822192192,
-0.13972750306129456,
0.19277678430080414,
0.1897961050271988,
-0.10552307963371277,
0.010528448969125748,
-0.301246702671051,
0.10683920979499817,
-0.1994035542011261,
0.053883880376815796,
0.013549048453569412,
-0.05318615958094597,
0.1731412410736084,
0.018231214955449104,
0.19972436130046844,
-0.2337879091501236,
0.07726843655109406,
-0.18012191355228424,
-0.003669681726023555,
-0.048565395176410675,
-0.015033898875117302,
-0.12026256322860718,
-0.015276926569640636,
0.18252095580101013,
0.1384439617395401,
-0.0780738890171051,
-0.06553898751735687,
0.2743365466594696,
0.07462223619222641,
-0.1710415929555893,
-0.23096619546413422,
-0.28696441650390625,
0.12595917284488678,
0.07224003970623016,
0.07220834493637085,
-0.01667550578713417,
0.08990133553743362,
-0.06823733448982239,
-0.20288123190402985,
-0.017425408586859703,
0.020665114745497704,
-0.05432678014039993,
0.11511212587356567,
0.11201188713312149,
-0.2265118658542633,
-0.007165470626205206,
-0.021275805309414864,
0.05600877106189728,
-0.15051567554473877,
0.0873626321554184,
-0.08291840553283691,
-0.0021013848017901182,
0.100594662129879,
-0.1086813434958458,
-0.2665184438228607,
-0.09314832836389542,
-0.1724761426448822,
-0.08989446610212326,
0.20784564316272736,
-0.24704933166503906,
-0.12780173122882843,
0.23575586080551147,
0.12368012964725494,
-0.18133722245693207,
0.04640929400920868,
0.09749813377857208,
0.11447376757860184
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. venous patterning or varicosities; large and complex vascular malformations affect some individuals. Vascular malformations are commonly recognized in the first months of life and are generally stable over time . Lymphatic vascular malformations can arise in any tissue that normally includes such vessels. These can be progressive and are often present with areas of lipomatous overgrowth, which can complicate surgical approaches to lipomas.The most urgent and life-threatening complication of PS can be deep vein thrombosis (DVT) and pulmonary embolism (PE) . Individuals with DVT can present with a palpable subcutaneous rope-like mass, swelling, erythema, pain, and distal venous congestion. Symptoms of PE include shortness of breath, chest pain, and cough which may include hemoptysis. The rarity of DVT and PE in the general pediatric population can result in a delay in diagnosis.Those with PS manifest skeletal and other overgrowth in areas where no vascular malformations are present (unlike some other overgrowth conditions).Importantly, arteriovenous malformation (AVM) is | [
-0.26637691259384155,
-0.0026049611624330282,
-0.05583551898598671,
-0.10500431060791016,
0.09612375497817993,
0.07501283288002014,
-0.12448933720588684,
0.003247798653319478,
-0.18436302244663239,
-0.054873134940862656,
0.16749873757362366,
-0.12676577270030975,
0.23679639399051666,
0.035900216549634933,
0.06418943405151367,
0.4429842531681061,
-0.11200238764286041,
0.014168238267302513,
0.10973763465881348,
-0.04234044626355171,
-0.2518007457256317,
-0.09635427594184875,
-0.13512372970581055,
0.10507529973983765,
0.043082840740680695,
0.016036730259656906,
0.3800460398197174,
0.3251512348651886,
0.03971526026725769,
0.014046669006347656,
-0.14519187808036804,
-0.0071057663299143314,
-0.08788903057575226,
-0.3352995216846466,
0.182302787899971,
-0.27263006567955017,
-0.17940185964107513,
0.17981913685798645,
0.19030886888504028,
0.1536957323551178,
-0.17585314810276031,
0.08196994662284851,
-0.23842497169971466,
-0.19535477459430695,
0.2973876893520355,
-0.04306706041097641,
0.03845890983939171,
0.23611505329608917,
-0.13037650287151337,
0.36336013674736023,
0.24728094041347504,
0.05919488146901131,
0.2565786838531494,
-0.04360564798116684,
0.06951121985912323,
-0.15301766991615295,
-0.008630764670670033,
-0.06509771943092346,
-0.2568235993385315,
0.07846450805664062,
0.20205019414424896,
-0.09065477550029755,
0.2811168134212494,
-0.4162445366382599,
0.05234241113066673,
-0.0246479120105505,
0.039170581847429276,
0.15029804408550262,
0.12228109687566757,
0.10808336734771729,
0.4684968590736389,
-0.23061272501945496,
-0.22021812200546265,
-0.03933149576187134,
0.27629774808883667,
0.05919588729739189,
-0.05374690145254135,
-0.17351214587688446,
-0.30025002360343933,
0.01387119572609663,
0.135623499751091,
-0.15533600747585297,
-0.17365626990795135,
-0.051972441375255585,
-0.24627424776554108,
-0.09269904345273972,
-0.1669742912054062,
0.10431645810604095,
-0.1958719938993454,
-0.10251152515411377,
0.12517878413200378,
-0.09091414511203766,
0.13288626074790955,
-0.05929404869675636,
0.274181067943573,
-0.1880941092967987,
-0.0024482833687216043,
0.05682780593633652,
-0.17071817815303802,
0.22594518959522247,
0.037691473960876465,
0.07853212207555771,
-0.16109013557434082,
0.03950170427560806,
-0.08956070989370346,
-0.15512612462043762,
-0.12481624633073807,
-0.10887672752141953,
0.09173699468374252,
0.06044383719563484,
0.057257845997810364,
-0.1034887507557869,
-0.014540337026119232,
-0.08161793649196625,
-0.31415265798568726,
-0.20866714417934418,
0.09528914093971252,
0.016328996047377586,
-0.10826454311609268,
-0.1944674551486969,
-0.19832348823547363,
-0.10117506980895996,
0.1422315239906311,
-0.15272018313407898,
0.21437735855579376,
-0.011537753976881504,
0.31235748529434204,
-0.04737212508916855,
0.010525399819016457,
-0.11210738867521286,
0.3050312399864197,
-0.3527432382106781,
-0.07767955958843231,
-0.23585455119609833,
0.08249405771493912,
0.14715805649757385,
0.09910258650779724,
0.05185384675860405,
0.19155018031597137,
0.11863721907138824,
0.33234819769859314,
0.0715847834944725,
0.32212355732917786,
0.24295534193515778,
-0.08899445831775665,
-0.03794252127408981,
0.24499770998954773,
0.18516995012760162,
0.20437785983085632,
-0.07663165777921677,
0.13576743006706238,
-0.13593323528766632,
0.21312323212623596,
-0.0048229689709842205,
-0.06265837699174881,
0.06030582636594772,
-0.08374825865030289,
-0.013834942132234573,
-0.21832479536533356,
-0.10735584050416946,
-0.04877525195479393,
-0.3645147383213043,
0.06467244774103165,
0.00634975777938962,
-0.02331235632300377,
0.20414085686206818,
0.08841805905103683,
-0.12908707559108734,
0.24991337954998016,
-0.07685153186321259,
-0.0661739706993103,
0.008458413183689117,
-0.10200237482786179,
-0.003048715414479375,
-0.018097734078764915,
-0.09953436255455017,
0.09070409834384918,
-0.019530991092324257,
-0.2110648900270462,
0.010658042505383492,
0.0798366516828537,
0.0898890569806099,
-0.10084143280982971,
-0.18222709000110626,
0.11470867693424225,
-0.08099917322397232,
0.15378449857234955,
0.11438324302434921,
-0.16454872488975525,
0.08584506064653397,
-0.0697363093495369,
0.05112987756729126,
-0.022944854572415352,
0.06418795883655548,
-0.17145662009716034,
-0.2643146216869354,
-0.10591856390237808,
-0.22241421043872833,
0.013549367897212505,
0.11491817981004715,
-0.058290302753448486,
0.1096687987446785,
0.10037606954574585,
0.027304956689476967,
0.2003783881664276,
0.04706916585564613,
-0.015131472609937191,
-0.22553274035453796,
0.004274526610970497,
0.05985897406935692,
-0.1878727227449417,
0.16541019082069397,
-0.05543780326843262,
-0.10342565923929214,
0.09478767216205597,
-0.017931727692484856,
-0.20646394789218903,
-0.10752937942743301,
0.03833325207233429,
0.04880232736468315,
-0.36513105034828186,
0.12782378494739532,
-0.09341001510620117,
-0.2999385595321655,
-0.23310524225234985,
-0.10355037450790405,
0.003532535396516323,
-0.07506652921438217,
0.05154607072472572,
0.027967680245637894,
-0.15404418110847473,
0.055022940039634705,
0.016811570152640343,
0.10141408443450928,
0.152278870344162,
-0.24916040897369385,
0.036526378244161606,
0.3401294946670532,
0.06402936577796936,
-0.021147949621081352,
-0.1368277370929718,
0.047009341418743134,
-0.1375884860754013,
-0.06130675971508026,
-0.032491911202669144,
0.050068024545907974,
-0.0367855466902256,
0.18949472904205322,
-0.007079572882503271,
-0.17773130536079407,
-0.04379531368613243,
-0.28415969014167786,
0.06539545953273773,
0.17546266317367554,
-0.368058443069458,
-0.1689414083957672,
0.2117539942264557,
-0.031778693199157715,
-0.032711211591959,
-0.008921191096305847,
0.21992963552474976,
0.07681312412023544,
0.3276467025279999,
0.08018748462200165,
-0.07192552834749222,
-0.0852237194776535,
-0.07802188396453857,
0.025255214422941208,
-0.2485433965921402,
-0.24397596716880798,
-0.08720962703227997,
0.19320890307426453,
0.09227028489112854,
0.09127873182296753,
-0.0689496248960495,
0.05840572342276573,
0.06910496950149536,
0.18119744956493378,
0.1383453607559204,
0.15862540900707245,
0.10682312399148941,
0.1191602498292923,
-0.056241028010845184,
-0.04262731224298477,
0.24798332154750824,
0.21993163228034973,
-0.27714380621910095,
0.05030325800180435,
0.19023212790489197,
-0.007600520737469196,
0.12110329419374466,
0.027892587706446648,
-0.15038225054740906,
-0.057544607669115067,
0.3725273013114929,
0.27283167839050293,
-0.18437276780605316,
-0.0061724078841507435,
0.07153945416212082,
-0.08925160765647888,
-0.036684807389974594,
0.3414054811000824,
-0.21234241127967834,
-0.10616125166416168,
0.027481308206915855,
-0.20109426975250244,
-0.10021337121725082,
-0.016345560550689697,
0.1272049993276596,
0.0018832371570169926,
-0.29390889406204224,
0.20977358520030975,
0.1674197018146515,
-0.06083407253026962,
-0.1619689017534256,
-0.017132218927145004,
0.12483902275562286,
-0.1184803694486618,
0.12073013931512833,
-0.04681995138525963,
-0.11003398895263672,
-0.04221353679895401,
0.04536880925297737,
0.19040198624134064,
-0.07630260288715363,
-0.0619165264070034,
-0.03128247335553169,
0.11677344143390656,
0.13066306710243225,
-0.10867024213075638,
-0.003398600732907653,
-0.019880477339029312,
-0.292878657579422,
-0.18920858204364777,
-0.10172033309936523,
0.11078711599111557,
-0.00023619277635589242,
-0.09120281040668488,
-0.06844770163297653,
-0.08168914914131165,
-0.23659227788448334,
-0.09083428233861923,
0.15566882491111755,
-0.20158933103084564,
0.08569548279047012,
0.12068486213684082,
0.07845906913280487,
0.02016320265829563,
-0.0018531387904658914,
-0.1996135711669922,
-0.07624056935310364,
-0.13342787325382233,
-0.02385922148823738,
-0.24338394403457642,
0.2546158730983734,
-0.013033399358391762,
-0.0417550764977932,
0.14994126558303833,
-0.13337597250938416,
-0.0337040014564991,
-0.17633724212646484,
0.11165699362754822,
-0.017604390159249306,
-0.24602113664150238,
0.09086980670690536,
0.0690360888838768,
-0.1279282569885254,
0.04321799799799919,
0.28263789415359497,
-0.049371298402547836,
0.14966213703155518,
0.08162590116262436,
0.0035455599427223206,
-0.1980167031288147,
-0.13924802839756012,
0.23539388179779053,
-0.23228132724761963,
0.028232630342245102,
-0.14167268574237823,
-0.23473283648490906,
-0.22161832451820374,
0.2056533843278885,
0.03747732937335968,
-0.08968409895896912,
-0.006549065932631493,
0.058768223971128464,
-0.29286906123161316,
0.29504165053367615,
-0.16269007325172424,
-0.07139629125595093,
0.2002885341644287,
0.12321607023477554,
-0.007838618941605091,
0.23109911382198334,
0.045734819024801254,
0.008757936768233776,
0.11722540855407715,
-0.24449744820594788,
-0.20195770263671875,
0.024201810359954834,
-0.07247953861951828,
-0.020472077652812004,
0.35185444355010986,
0.32948705554008484,
0.16636882722377777,
-0.07482103258371353,
-0.055079925805330276,
-0.08344651758670807,
0.032088663429021835,
0.2730412483215332,
-0.1166105642914772,
-0.026124682277441025,
-0.08264420181512833,
-0.08976208418607712,
-0.3065204918384552,
-0.20834282040596008,
-0.13477760553359985,
-0.14532077312469482,
0.28590890765190125,
0.01675652153789997,
0.049172528088092804,
0.022163718938827515,
0.24120980501174927,
-0.07706674188375473,
-0.30440327525138855,
0.0573224313557148,
-0.01578422263264656,
-0.023164495825767517,
0.022677266970276833,
0.19898636639118195,
0.3678811490535736,
-0.14054667949676514,
-0.2868320345878601,
0.06923536956310272,
0.21727894246578217,
-0.022505613043904305,
-0.09609629958868027,
0.31632164120674133,
0.15747839212417603,
0.02110162563621998,
0.30687034130096436,
0.11197888106107712,
0.18062029778957367,
0.22932802140712738,
0.04601624608039856,
-0.05809712037444115,
0.1257617324590683,
0.2796460688114166,
0.008904440328478813,
0.25162050127983093,
0.030543530359864235,
-0.03923403099179268,
0.12828433513641357,
0.03018672950565815,
0.257968932390213,
0.09306599944829941,
-0.26232948899269104,
0.07753930240869522,
-0.07957843691110611,
0.0671822801232338,
-0.08215388655662537,
0.1862625777721405,
0.13468270003795624,
0.024051999673247337,
-0.07484287023544312,
0.11579474061727524,
-0.2415591925382614,
0.0171454306691885,
-0.07143072783946991,
-0.04552961140871048,
0.13149245083332062,
0.17765279114246368,
0.20529145002365112,
-0.08553873747587204,
-0.23042915761470795,
0.23359785974025726,
-0.3010687828063965,
0.08366028219461441,
-0.058111973106861115,
0.21763131022453308,
0.13109441101551056,
0.19887392222881317,
-0.052395038306713104,
-0.16798639297485352,
0.07844000309705734,
0.1766459196805954,
0.28420519828796387,
-0.11435767263174057,
0.4689900875091553,
-0.12756499648094177,
0.17528139054775238,
-0.0607561394572258,
0.07196144759654999,
0.4637675881385803,
-0.0771743431687355,
0.014309489168226719,
0.15529170632362366,
0.056409094482660294,
-0.014107604511082172,
-0.0034904240164905787,
-0.19492098689079285,
0.07380416989326477,
0.08690988272428513,
0.06434719264507294,
0.2576371431350708,
0.16824282705783844,
0.02413012646138668,
-0.267608642578125,
-0.11301720887422562,
0.11502368748188019,
-0.14383748173713684,
-0.3067761957645416,
-0.10633741319179535,
-0.11770589649677277,
0.01337681245058775,
0.15449832379817963,
-0.09962749481201172,
0.23013640940189362,
0.09619221091270447,
-0.09527885913848877,
-0.19338993728160858,
-0.13774234056472778,
0.0520147942006588,
-0.09973300993442535,
-0.16846570372581482,
-0.0661897212266922,
-0.16024543344974518,
0.33708062767982483,
-0.23643217980861664,
-0.04593996703624725,
-0.10837901383638382,
0.10489664226770401,
0.049890149384737015,
0.10679268836975098,
0.07093788683414459,
-0.09689658135175705,
0.15999464690685272,
-0.0962400883436203,
0.02460993267595768,
0.21146667003631592,
0.08782243728637695,
-0.05526367202401161,
0.10236062854528427,
0.3759002387523651,
-0.2797282040119171,
0.20534494519233704,
0.2571713328361511,
-0.05898864194750786,
0.02831748127937317,
0.07604938000440598,
0.2579652965068817,
0.06329917162656784,
-0.005820795428007841,
-0.2573484778404236,
-0.07999469339847565,
0.02629980258643627,
0.13011959195137024,
0.09765330702066422,
-0.028360968455672264,
0.24435573816299438,
-0.21822166442871094,
0.0870758593082428,
-0.016590114682912827,
-0.031065519899129868,
-0.03757353499531746,
0.3178263008594513,
0.5229014158248901,
-0.08580154925584793,
-0.027723347768187523,
-0.16249684989452362,
0.15270334482192993,
-0.16214849054813385,
0.023927979171276093,
-0.2689821720123291,
-0.305349200963974,
-0.08343907445669174,
-0.311783105134964,
-0.16725635528564453,
-0.1247076690196991,
0.17121367156505585,
0.012626673094928265,
-0.3947029709815979,
-0.20590832829475403,
-0.24838827550411224,
0.16500848531723022,
0.20840047299861908,
0.038427695631980896,
0.2568696439266205,
0.19667688012123108,
0.1588384211063385,
-0.13322633504867554,
-0.1405809223651886,
0.01854497380554676,
-0.03928624466061592,
0.21127572655677795,
-0.07977702468633652,
-0.1280408501625061,
-0.03709481284022331,
0.012496956624090672,
-0.1001097783446312,
0.1302996724843979,
0.15035496652126312,
0.08033726364374161,
-0.12731848657131195,
-0.03386354818940163,
0.2250140756368637,
0.203770250082016,
-0.2079995721578598,
0.21197965741157532,
0.05914948508143425,
-0.17092716693878174,
-0.17841272056102753,
0.1979304999113083,
0.012354929000139236,
0.12366101145744324,
-0.43956291675567627,
-0.03346136584877968,
0.05198616907000542,
0.13736779987812042,
-0.07750233262777328,
0.5388450026512146,
0.02346198260784149,
0.3225841522216797,
0.04904730245471001,
-0.1343127340078354,
-0.005576213356107473,
-0.11060666292905807,
0.1412465125322342,
0.18768586218357086,
-0.029632650315761566,
0.1418745368719101,
-0.268917977809906,
0.0351848378777504,
0.24491335451602936,
0.04229174926877022,
0.3235587179660797,
-0.1155337542295456,
-0.2426709085702896,
0.0028686418663710356,
0.00019603008695412427,
-0.0022381655871868134,
0.03440925478935242,
0.06172387674450874,
0.11666349321603775,
-0.28322508931159973,
0.1670120358467102,
0.09306710958480835,
-0.017950931563973427,
-0.057113777846097946,
-0.40652573108673096,
-0.014209885150194168,
0.14071939885616302,
0.1054370328783989,
-0.06305476278066635,
-0.15350377559661865,
0.016914429143071175,
0.23179279267787933,
-0.11058364808559418,
-0.015979601070284843,
0.15882009267807007,
-0.06042325496673584,
-0.0946803167462349,
-0.03347310423851013,
0.013044404797255993,
-0.0012929087970405817,
0.028884734958410263,
0.12727636098861694,
0.13315045833587646,
-0.1921273022890091,
-0.01190526969730854,
-0.04548252001404762,
0.2193160057067871,
0.022652102634310722,
0.11687667667865753,
-0.00015824424917809665,
-0.023128017783164978,
-0.08018695563077927,
-0.1827501803636551,
0.102964386343956,
0.37372878193855286,
0.06994915008544922,
-0.3727266788482666,
0.026116011664271355,
-0.12147030234336853,
0.08136966079473495,
-0.17914548516273499,
-0.016557086259126663,
-0.06372087448835373,
0.2562200129032135,
-0.11339278519153595,
0.04331870749592781,
-0.03214336559176445,
0.058511704206466675,
0.1368074119091034,
-0.048942286521196365,
-0.26782864332199097,
0.24283607304096222,
-0.02545122802257538,
-0.08726957440376282,
0.2367570549249649,
-0.007641850505024195,
0.1450648456811905,
-0.09840427339076996,
0.17275620996952057,
0.09115266054868698,
-0.08263437449932098,
-0.1553381383419037,
-0.3035946190357208,
0.1734176129102707,
-0.2722960412502289,
0.16867037117481232,
-0.07817728817462921,
-0.1232471615076065,
0.2791864573955536,
-0.09742283821105957,
0.26848432421684265,
-0.3612458109855652,
0.07103540748357773,
-0.19512662291526794,
0.054971616715192795,
-0.1472054272890091,
0.07729750871658325,
-0.17933551967144012,
0.12555155158042908,
0.23571991920471191,
0.15834985673427582,
-0.2524624764919281,
-0.06795348972082138,
0.23442359268665314,
0.02662072330713272,
-0.11162053793668747,
-0.33965370059013367,
-0.23669520020484924,
0.19939662516117096,
0.018224600702524185,
0.1380487084388733,
0.04730385169386864,
-0.0009338320815004408,
-0.11497703939676285,
-0.28764116764068604,
-0.0376269705593586,
0.05634460970759392,
-0.05454137176275253,
0.1256781369447708,
0.1181766614317894,
-0.04856100678443909,
-0.1010543704032898,
0.002961615100502968,
-0.027283599600195885,
0.01088507380336523,
0.08462869375944138,
-0.09592889994382858,
0.0009786654263734818,
0.014016976580023766,
-0.1379377841949463,
-0.40332865715026855,
-0.11268965154886246,
-0.06497729569673538,
-0.06904567033052444,
0.2691536247730255,
-0.37808653712272644,
-0.09356266260147095,
0.18617576360702515,
0.036819398403167725,
-0.06461700052022934,
-0.0361442044377327,
0.2078966200351715,
0.10579630732536316
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. PE) . Individuals with DVT can present with a palpable subcutaneous rope-like mass, swelling, erythema, pain, and distal venous congestion. Symptoms of PE include shortness of breath, chest pain, and cough which may include hemoptysis. The rarity of DVT and PE in the general pediatric population can result in a delay in diagnosis.Those with PS manifest skeletal and other overgrowth in areas where no vascular malformations are present (unlike some other overgrowth conditions).Importantly, arteriovenous malformation (AVM) is uncommon in PS.Tumors, most of which are benign. Tumors observed in multiple individuals include meningiomas, ovarian cystadenomas, and parotid monomorphic adenomas. A number of other tumors have been seen in individual patients with PS. It is presumed that PS causes a modest but significant increase in many types of tumors, in contrast to other syndromes that are associated with a very specific subset of tumors.Bullous pulmonary disease is uncommon but does affect some individuals with PS , most | [
-0.22979636490345,
-0.08442099392414093,
-0.040028177201747894,
-0.1261504888534546,
0.1226465180516243,
0.0026851152069866657,
-0.12788134813308716,
-0.12782837450504303,
-0.07928778976202011,
0.0941813737154007,
0.21310055255889893,
-0.0849839299917221,
-0.03383924439549446,
-0.05711863562464714,
-0.1829676777124405,
0.1860388070344925,
-0.21488907933235168,
-0.03603123873472214,
-0.04968236759305,
0.05610797554254532,
-0.02438088320195675,
-0.022123483940958977,
-0.026552187278866768,
0.21407487988471985,
0.04281162470579147,
-0.14058566093444824,
0.22742106020450592,
0.2517944276332855,
-0.030044149607419968,
-0.06394999474287033,
-0.14407524466514587,
-0.035742729902267456,
-0.1971701830625534,
-0.36902254819869995,
0.07709487527608871,
-0.2510436475276947,
-0.26372841000556946,
0.10528786480426788,
0.17502284049987793,
0.08889584988355637,
-0.11783987283706665,
0.10820217430591583,
-0.17222021520137787,
-0.08851847797632217,
0.2786307632923126,
-0.06218336522579193,
-0.011151733808219433,
0.10454783588647842,
0.07339735329151154,
0.27891820669174194,
0.19583329558372498,
-0.054929785430431366,
0.1633814126253128,
-0.12916916608810425,
0.037509430199861526,
-0.21851806342601776,
-0.0475347638130188,
-0.05728807672858238,
-0.3891674876213074,
0.1144968718290329,
0.21585382521152496,
0.019993094727396965,
0.2643919587135315,
-0.29421478509902954,
-0.020948020741343498,
-0.11275475472211838,
-0.10951198637485504,
0.11758267134428024,
0.13883478939533234,
0.002561436966061592,
0.3279132843017578,
-0.06941836327314377,
-0.1453222930431366,
-0.025618305429816246,
0.016853200271725655,
-0.07112418860197067,
0.02077019214630127,
-0.14919963479042053,
-0.12255781143903732,
-0.1269611418247223,
0.07067163288593292,
-0.10840332508087158,
-0.11770165711641312,
0.0851450189948082,
-0.19903607666492462,
-0.0463753417134285,
-0.04558387026190758,
-0.013974928297102451,
-0.09252512454986572,
-0.16272883117198944,
0.05485500395298004,
-0.18305006623268127,
0.07221614569425583,
0.09045980125665665,
0.23032285273075104,
-0.07521049678325653,
0.04683594033122063,
0.03698587790131569,
-0.18319469690322876,
-0.020923884585499763,
0.10162699967622757,
0.32635557651519775,
-0.011045931838452816,
-0.10125786066055298,
0.06108768656849861,
-0.1289833039045334,
-0.06319916993379593,
0.03703254833817482,
-0.004532825201749802,
0.024995069950819016,
0.013430382125079632,
-0.14477616548538208,
-0.0765109658241272,
-0.06070765107870102,
-0.26891589164733887,
-0.15496982634067535,
0.016622819006443024,
-0.09055349230766296,
-0.1434624195098877,
-0.2156028002500534,
-0.05972137674689293,
-0.15552251040935516,
0.058022212237119675,
-0.07624485343694687,
0.12136644124984741,
0.03739694133400917,
0.25429999828338623,
-0.1811547726392746,
0.05199188366532326,
-0.029172241687774658,
0.24046862125396729,
-0.2590444087982178,
0.004732367116957903,
-0.2495735138654709,
0.11180003732442856,
0.172940194606781,
0.1456734985113144,
-0.14561675488948822,
0.11624370515346527,
0.016414180397987366,
0.3010347783565521,
0.0865231603384018,
0.28843584656715393,
0.18184274435043335,
-0.14133958518505096,
-0.10904966294765472,
0.2293311059474945,
0.10546716302633286,
0.09364558756351471,
-0.08692383766174316,
0.1739131063222885,
-0.1501569300889969,
0.14359453320503235,
0.0029658074490725994,
-0.010331418365240097,
-0.0879574790596962,
-0.03430686146020889,
0.07223067432641983,
-0.12386956065893173,
-0.07173534482717514,
-0.04108494520187378,
-0.15856459736824036,
0.009654244408011436,
-0.18826253712177277,
-0.025652537122368813,
0.008196597918868065,
0.06352142989635468,
-0.10603184252977371,
0.20474712550640106,
-0.06921721994876862,
-0.07930757105350494,
-0.05797563120722771,
-0.1526675671339035,
0.07605936378240585,
-0.1238914281129837,
0.012713245116174221,
0.01709604263305664,
0.06328492611646652,
-0.1597180813550949,
0.08781249821186066,
-0.0012351139448583126,
-0.05355418846011162,
-0.11629670858383179,
-0.24306213855743408,
0.009863996878266335,
-0.12594477832317352,
0.06184031441807747,
0.1523706018924713,
-0.055833347141742706,
0.01414776872843504,
0.064613938331604,
-0.03212229162454605,
-0.1308787316083908,
0.08730459958314896,
-0.15185171365737915,
-0.3947044610977173,
0.003717421554028988,
-0.15570837259292603,
0.026263821870088577,
0.15542805194854736,
0.16914594173431396,
0.005127723328769207,
0.09037787467241287,
0.020654594525694847,
0.13835784792900085,
-0.0074071926064789295,
0.0686725601553917,
-0.18811462819576263,
0.09001199156045914,
0.13423101603984833,
-0.10292491316795349,
0.2348821610212326,
-0.1892896443605423,
0.006127358414232731,
0.13566464185714722,
-0.07278931140899658,
-0.1957634687423706,
-0.12286236882209778,
-0.032034456729888916,
0.10848291963338852,
-0.32658666372299194,
0.1189441978931427,
-0.1253816932439804,
-0.25816166400909424,
-0.25819388031959534,
0.08776219934225082,
-0.07675802707672119,
-0.10960811376571655,
0.07467822730541229,
0.06997085362672806,
-0.13820242881774902,
0.09013441205024719,
-0.04279472306370735,
0.24074004590511322,
0.03506055846810341,
-0.2676827013492584,
-0.11636239290237427,
0.27779459953308105,
-0.07584334164857864,
0.13237307965755463,
-0.07888499647378922,
0.009603040292859077,
-0.01993555761873722,
-0.01696494035422802,
-0.1019919365644455,
0.04584932699799538,
0.07410143315792084,
0.015060731209814548,
-0.07760413736104965,
-0.15698771178722382,
0.13237981498241425,
-0.3151644766330719,
0.1909637302160263,
0.27266520261764526,
-0.18029198050498962,
-0.10505343973636627,
0.1942266821861267,
-0.12409708648920059,
0.07753050327301025,
0.13152550160884857,
0.07852189987897873,
0.17690245807170868,
0.25720521807670593,
-0.1170598641037941,
-0.16826273500919342,
-0.23832456767559052,
-0.0003470934752840549,
0.20819100737571716,
-0.2290712594985962,
-0.24148012697696686,
-0.03364098444581032,
0.2634941339492798,
0.08829773217439651,
-0.024110805243253708,
-0.030895913019776344,
-0.005458259955048561,
-0.04342924430966377,
0.009250027127563953,
0.13805726170539856,
0.19208671152591705,
0.05578317493200302,
0.01965525932610035,
-0.11538361757993698,
-0.08821932971477509,
0.3123079538345337,
0.18631137907505035,
-0.3280583620071411,
0.1630355417728424,
0.05665060505270958,
-0.03160678967833519,
0.14909420907497406,
0.1615583449602127,
0.05140982195734978,
-0.09937764704227448,
0.14505909383296967,
0.15880343317985535,
-0.06891552358865738,
0.004756817128509283,
0.14940275251865387,
-0.05593811348080635,
0.06696457415819168,
0.25382930040359497,
-0.10777733474969864,
0.08213374763727188,
-0.017913319170475006,
-0.10982455313205719,
0.08075549453496933,
0.024858612567186356,
0.03647098317742348,
-0.10959505289793015,
-0.18734465539455414,
0.2911059260368347,
0.15639705955982208,
0.026934362947940826,
-0.08382096141576767,
-0.011615409515798092,
-0.09618695825338364,
-0.023774897679686546,
0.14063286781311035,
-0.014371506869792938,
-0.10223681479692459,
-0.14331763982772827,
0.07920514792203903,
0.13328683376312256,
0.011373738758265972,
0.01323063112795353,
-0.05672628805041313,
0.17079110443592072,
-0.05772222951054573,
-0.021359991282224655,
-0.059486694633960724,
0.028648823499679565,
-0.14843349158763885,
-0.2202480137348175,
0.0025437441654503345,
0.0928652286529541,
0.09200974553823471,
-0.06075204908847809,
-0.01418063323944807,
-0.1462205946445465,
-0.1233488917350769,
-0.24636049568653107,
0.020022114738821983,
-0.04198180511593819,
0.05571203678846359,
0.09148416668176651,
0.027350494638085365,
0.08136909455060959,
-0.07380609959363937,
-0.23002175986766815,
-0.04842614009976387,
-0.16165795922279358,
0.0254465751349926,
-0.31603315472602844,
0.10965269058942795,
0.05558722838759422,
-0.04015321657061577,
0.0633605420589447,
-0.031422458589076996,
0.0850105807185173,
-0.11258682608604431,
0.044536665081977844,
-0.15062102675437927,
-0.11621566116809845,
-0.007508344482630491,
-0.011494416743516922,
-0.21289876103401184,
-0.04469453543424606,
0.2909451425075531,
-0.0014119084225967526,
0.3069682717323303,
0.18337564170360565,
0.11548513919115067,
-0.315734326839447,
-0.015890175476670265,
0.07608920335769653,
-0.26968199014663696,
-0.014869625680148602,
-0.16016089916229248,
-0.1685505211353302,
-0.2390621304512024,
0.17237508296966553,
0.16754557192325592,
-0.1187552884221077,
-0.08764255791902542,
-0.07779520004987717,
-0.12991563975811005,
0.19104929268360138,
0.022053934633731842,
-0.22897328436374664,
0.24187244474887848,
-0.0015716376947239041,
0.09600237011909485,
0.2047935277223587,
-0.019589124247431755,
-0.00901881605386734,
0.026502544060349464,
-0.21371786296367645,
-0.23296654224395752,
-0.013070579618215561,
0.10170381516218185,
0.04710253328084946,
0.15223728120326996,
0.29546165466308594,
0.11447785049676895,
-0.06636251509189606,
-0.22268597781658173,
0.011908724904060364,
-0.033047012984752655,
0.33545824885368347,
-0.12108248472213745,
-0.060430675745010376,
-0.055992163717746735,
-0.07180085778236389,
-0.17597712576389313,
-0.20153720676898956,
-0.1381448656320572,
-0.04130874201655388,
0.12379610538482666,
-0.09836557507514954,
0.10474026948213577,
-0.08657580614089966,
0.10693985968828201,
-0.08807478100061417,
-0.18353445827960968,
0.033944450318813324,
-0.02290257252752781,
0.026607543230056763,
-0.053513433784246445,
0.14014632999897003,
0.20147839188575745,
-0.1394665390253067,
-0.2650735080242157,
0.11707080900669098,
0.06684888899326324,
0.09541922807693481,
-0.0966949313879013,
0.16316713392734528,
0.11625251919031143,
-0.01695098914206028,
0.425135999917984,
0.04382111877202988,
0.16987206041812897,
0.10258056223392487,
-0.011870300397276878,
0.01207658089697361,
-0.034689612686634064,
0.011069091036915779,
0.017108473926782608,
0.12067528814077377,
0.015379215590655804,
-0.1167479008436203,
0.11178825795650482,
0.03543740138411522,
0.08402030169963837,
0.07734028995037079,
-0.1489461064338684,
0.11336030811071396,
-0.10886625945568085,
0.07472337782382965,
-0.04347134381532669,
0.12354575097560883,
0.11743613332509995,
0.062624491751194,
0.08120223134756088,
0.06093154847621918,
-0.26284366846084595,
0.04957784712314606,
-0.047281939536333084,
0.0076570576056838036,
0.007206848356872797,
0.10501193255186081,
0.18144597113132477,
-0.06229615584015846,
-0.13883613049983978,
-0.007932795211672783,
-0.1261633336544037,
0.042556166648864746,
-0.12236010283231735,
0.20046021044254303,
0.14526554942131042,
0.05570303648710251,
0.05937784165143967,
-0.12908725440502167,
0.000008528452781320084,
0.08307824283838272,
0.14931707084178925,
-0.11707417666912079,
0.31323084235191345,
-0.13190533220767975,
0.22896923124790192,
0.03304128721356392,
0.004221773240715265,
0.3946227431297302,
0.07437852025032043,
0.03482954576611519,
0.20416449010372162,
0.1946803778409958,
0.006046395283192396,
-0.07732914388179779,
0.009367614984512329,
0.03133721649646759,
0.005948888137936592,
-0.054360531270504,
0.028423361480236053,
0.033123929053545,
0.05723992735147476,
-0.3024882376194,
-0.1261795312166214,
0.08227980136871338,
-0.12433890998363495,
-0.12812727689743042,
-0.04354925453662872,
-0.17162923514842987,
0.08394496142864227,
0.06929508596658707,
-0.1027412936091423,
0.15445519983768463,
0.13049766421318054,
-0.015753421932458878,
-0.05409414321184158,
-0.12038072198629379,
0.056206975132226944,
0.059130508452653885,
-0.1650324910879135,
-0.11836429685354233,
-0.06262680888175964,
0.1012958288192749,
-0.0616944395005703,
-0.06384268403053284,
-0.059135060757398605,
-0.09595213085412979,
0.08522194623947144,
0.011418815702199936,
0.1591796725988388,
-0.0648193284869194,
0.04669574648141861,
-0.04565918445587158,
-0.09744936972856522,
0.15582388639450073,
-0.09689439088106155,
0.07476912438869476,
0.1317819505929947,
0.08607420325279236,
-0.16825850307941437,
0.09451251477003098,
0.0893222838640213,
0.0007580991368740797,
-0.054560597985982895,
0.12834122776985168,
0.17091917991638184,
0.0437077134847641,
-0.03666992485523224,
-0.14034761488437653,
0.035949546843767166,
-0.008068346418440342,
0.1197669506072998,
0.08103352785110474,
0.04228799417614937,
0.41652563214302063,
-0.05176036059856415,
0.17486125230789185,
-0.006645231042057276,
-0.021787479519844055,
-0.09610075503587723,
0.28400176763534546,
0.28421685099601746,
0.008078118786215782,
-0.05891762673854828,
-0.022517574951052666,
0.003286925842985511,
-0.09598612785339355,
0.12756852805614471,
-0.1445518136024475,
-0.18642418086528778,
0.009271960705518723,
-0.18477970361709595,
-0.12988795340061188,
-0.13455800712108612,
0.11764441430568695,
0.17099592089653015,
-0.2198408842086792,
-0.09752137959003448,
-0.2352657914161682,
0.06820090115070343,
0.2061479240655899,
-0.13320688903331757,
0.22302109003067017,
0.3081325590610504,
0.14858217537403107,
-0.04260839521884918,
-0.11699171364307404,
0.07825934886932373,
-0.15135279297828674,
0.13970839977264404,
-0.16010530292987823,
0.03371497243642807,
-0.012684790417551994,
-0.09518931061029434,
-0.0158404428511858,
0.05526938661932945,
0.14566507935523987,
-0.1831517368555069,
-0.13004781305789948,
-0.10711263120174408,
0.017540913075208664,
0.1332595944404602,
-0.09883684664964676,
0.3446063697338104,
-0.07153326272964478,
-0.16256102919578552,
-0.171819806098938,
0.19398543238639832,
-0.030819369480013847,
0.00711431261152029,
-0.3718200623989105,
0.1321750432252884,
-0.10765227675437927,
0.11659631133079529,
-0.037599608302116394,
0.39103421568870544,
0.006154946982860565,
0.07699611037969589,
-0.07666383683681488,
-0.05123915150761604,
0.2597428560256958,
-0.033495549112558365,
-0.03122018463909626,
0.18575918674468994,
-0.08230363577604294,
0.049000613391399384,
-0.10808606445789337,
-0.023998212069272995,
0.09248186647891998,
0.11700829863548279,
0.14382772147655487,
0.0014359711203724146,
-0.15265242755413055,
0.035107433795928955,
-0.17139655351638794,
-0.1233241856098175,
0.08107537031173706,
0.11958236247301102,
0.1683262437582016,
-0.19673238694667816,
0.24328909814357758,
-0.08431266248226166,
-0.2797141373157501,
-0.29404622316360474,
-0.30293500423431396,
-0.18359360098838806,
0.07146930694580078,
0.15104058384895325,
-0.05891307443380356,
0.014265833422541618,
-0.08168869465589523,
0.21840420365333557,
0.003943226765841246,
-0.018312744796276093,
0.019172457978129387,
-0.026054278016090393,
-0.04542243108153343,
-0.23954491317272186,
-0.049174755811691284,
0.12323974817991257,
0.12689721584320068,
-0.04172855243086815,
0.1571701169013977,
-0.04624299332499504,
-0.26682791113853455,
-0.10545698553323746,
0.20505467057228088,
0.1898225098848343,
0.020851364359259605,
-0.017677277326583862,
0.1459088772535324,
0.20698466897010803,
-0.31300318241119385,
0.041080914437770844,
0.3848477602005005,
-0.06811881810426712,
-0.36235669255256653,
-0.01010627206414938,
-0.3028184771537781,
0.1053013727068901,
-0.10940009355545044,
-0.19978417456150055,
-0.06975004076957703,
0.19269846379756927,
-0.06270531564950943,
-0.03061807155609131,
-0.029364578425884247,
-0.13148389756679535,
0.072598896920681,
-0.05889732390642166,
-0.16895167529582977,
0.30525192618370056,
0.06263163685798645,
0.023311490193009377,
-0.01621444709599018,
-0.04821522906422615,
0.14474651217460632,
0.04591812565922737,
0.021902380511164665,
0.14452920854091644,
0.013065895065665245,
0.02351163513958454,
-0.2308373898267746,
0.06998183578252792,
-0.2683960199356079,
0.057952966541051865,
-0.0036903368309140205,
-0.009952475316822529,
0.33063241839408875,
0.057383157312870026,
0.18205907940864563,
-0.26869040727615356,
-0.1235046237707138,
-0.17574644088745117,
0.03612827509641647,
-0.027827952057123184,
0.04306749626994133,
0.03016160987317562,
-0.041545987129211426,
0.3097546398639679,
0.06424801796674728,
-0.1407407969236374,
-0.09351141005754471,
0.11120344698429108,
-0.04020804911851883,
-0.061043620109558105,
-0.15907391905784607,
-0.14400999248027802,
0.05217193439602852,
0.12609854340553284,
0.03015724942088127,
-0.03371362015604973,
-0.014234376139938831,
-0.16206659376621246,
-0.13208571076393127,
-0.028676412999629974,
-0.11140329390764236,
-0.006346875336021185,
0.025552131235599518,
0.1192299872636795,
-0.20558857917785645,
-0.04658164456486702,
0.11825378239154816,
0.03773157671093941,
-0.10444645583629608,
0.001257000956684351,
-0.10506650805473328,
0.08345635235309601,
0.04310758784413338,
-0.11401686072349548,
-0.16627085208892822,
-0.1527584195137024,
-0.04008999839425087,
-0.16623589396476746,
0.17707762122154236,
-0.14235356450080872,
-0.15076695382595062,
0.06468863785266876,
0.11296023428440094,
-0.09801328182220459,
0.18889546394348145,
0.10405076295137405,
0.1697855293750763
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. malformation (AVM) is uncommon in PS.Tumors, most of which are benign. Tumors observed in multiple individuals include meningiomas, ovarian cystadenomas, and parotid monomorphic adenomas. A number of other tumors have been seen in individual patients with PS. It is presumed that PS causes a modest but significant increase in many types of tumors, in contrast to other syndromes that are associated with a very specific subset of tumors.Bullous pulmonary disease is uncommon but does affect some individuals with PS , most commonly in late childhood or adolescence. As with other disease manifestations, this can progress with startling rapidity. It commonly manifests by reduced exercise tolerance or as an incidental finding from chest imaging.Dysmorphic facial features typically evolve during childhood and are not obvious at birth. Reported facial features include dolichocephaly, long face, downslanting palpebral fissures, and/or minor ptosis, depressed nasal bridge, wide or anteverted nares, | [
-0.03543862700462341,
0.02839440479874611,
-0.01948288455605507,
-0.2686852514743805,
0.11762154847383499,
-0.13133177161216736,
-0.2413109838962555,
-0.047195915132761,
-0.17469985783100128,
0.009003800339996815,
0.1493312120437622,
-0.11116857826709747,
-0.005810577422380447,
0.035853609442710876,
-0.0787176787853241,
-0.013887097127735615,
-0.027093034237623215,
0.06487035006284714,
-0.013239767402410507,
0.020746929571032524,
-0.00958583690226078,
-0.03961572051048279,
-0.05474819988012314,
0.14365877211093903,
-0.020104266703128815,
-0.20979662239551544,
0.14177389442920685,
0.15837052464485168,
-0.013089940883219242,
0.009991934522986412,
0.008997099474072456,
0.035714928060770035,
-0.17437699437141418,
-0.24203765392303467,
0.16409094631671906,
-0.23887206614017487,
-0.050658218562603,
0.09895205497741699,
0.01714683324098587,
0.09484247863292694,
-0.08701643347740173,
-0.07006099820137024,
-0.04237838089466095,
-0.1408938616514206,
0.34549352526664734,
-0.10708536952733994,
0.0756366029381752,
0.0731758326292038,
0.1484711468219757,
0.035097818821668625,
0.08839627355337143,
-0.1847834587097168,
0.15102246403694153,
-0.06652211397886276,
-0.012189400382339954,
-0.2655387222766876,
-0.08003605902194977,
-0.07868052273988724,
-0.28481295704841614,
0.1597079634666443,
0.27867260575294495,
-0.02150283195078373,
0.211733877658844,
-0.3417518734931946,
0.12291142344474792,
-0.15032759308815002,
-0.054842282086610794,
0.1175922155380249,
0.16569234430789948,
-0.06901989132165909,
0.42534512281417847,
0.002969342516735196,
-0.030523456633090973,
-0.025247624143958092,
-0.08855535089969635,
-0.1112859770655632,
-0.002926544053480029,
-0.0956418439745903,
0.05178011953830719,
-0.15148065984249115,
-0.02100607007741928,
-0.0204792283475399,
0.01280292123556137,
0.09663502871990204,
-0.30629950761795044,
-0.07389693707227707,
-0.0400332547724247,
0.04485142230987549,
0.008669980801641941,
-0.06562968343496323,
-0.002283806446939707,
-0.12843285501003265,
-0.060531165450811386,
0.04339059442281723,
0.23988990485668182,
-0.03763003647327423,
0.2134360373020172,
0.18597614765167236,
-0.2714923620223999,
-0.05564846098423004,
-0.059575147926807404,
0.29533395171165466,
0.004556316416710615,
-0.04683122783899307,
0.01411630492657423,
-0.07415840029716492,
-0.04571595415472984,
0.028556080535054207,
-0.012396077625453472,
0.10324881225824356,
0.020854195579886436,
-0.04108825698494911,
0.05629991739988327,
-0.08461242914199829,
-0.13764522969722748,
-0.11693540215492249,
-0.06445576250553131,
-0.053544845432043076,
-0.1910845786333084,
-0.20120611786842346,
0.220414936542511,
-0.11400431394577026,
0.12071847170591354,
0.059861961752176285,
0.1833457350730896,
0.0318714939057827,
0.18975895643234253,
-0.10903368145227432,
0.042063552886247635,
-0.01916690170764923,
0.17710062861442566,
-0.18718302249908447,
-0.0958418920636177,
-0.2992170751094818,
0.17316360771656036,
0.1713005155324936,
0.030835483223199844,
-0.30622076988220215,
-0.018842607736587524,
0.13291895389556885,
0.2032948136329651,
0.03205709531903267,
0.2863967716693878,
0.15991941094398499,
0.07327655702829361,
-0.17742919921875,
0.33334434032440186,
0.17946574091911316,
0.10813325643539429,
-0.08196688443422318,
0.1674862504005432,
-0.15476253628730774,
0.1502460539340973,
-0.05027909204363823,
-0.134494811296463,
-0.04678913205862045,
-0.012538750655949116,
0.09256112575531006,
-0.18848855793476105,
0.0904664620757103,
-0.1262662261724472,
-0.27062365412712097,
0.016024135053157806,
-0.0948033258318901,
-0.05007195472717285,
0.1585821807384491,
0.07764843851327896,
-0.19083863496780396,
0.17110970616340637,
-0.04547974094748497,
-0.08370250463485718,
-0.02319047413766384,
-0.027926649898290634,
0.1274840384721756,
-0.2150098979473114,
0.3196702301502228,
0.04271479323506355,
0.01746104098856449,
-0.07766730338335037,
-0.007360296323895454,
0.1926121711730957,
-0.21169382333755493,
-0.311165452003479,
-0.3668805658817291,
0.015156173147261143,
-0.1469024419784546,
-0.005090936552733183,
0.18953397870063782,
-0.13622090220451355,
0.15081080794334412,
0.17460110783576965,
0.006546862423419952,
-0.2560129761695862,
0.12635023891925812,
-0.10560265183448792,
-0.5275232791900635,
0.030526991933584213,
-0.09215646982192993,
-0.03319097310304642,
0.06488355994224548,
0.12037117034196854,
-0.055253010243177414,
0.07869402319192886,
0.01990552246570587,
0.09203261882066727,
-0.01671958528459072,
0.08266005665063858,
-0.2359713315963745,
0.18820124864578247,
0.06767284125089645,
-0.11206647753715515,
0.34110310673713684,
-0.1735350489616394,
-0.04269340634346008,
0.025537630543112755,
-0.052604351192712784,
-0.1797540783882141,
-0.1934603899717331,
-0.2393028438091278,
0.011624215170741081,
-0.2799047529697418,
0.10735606402158737,
-0.05913824215531349,
-0.16272605955600739,
-0.22115552425384521,
-0.03218692168593407,
-0.07832247018814087,
-0.07813428342342377,
0.22742962837219238,
-0.0033530050422996283,
-0.11163949966430664,
0.08560068905353546,
-0.13399624824523926,
0.23007991909980774,
0.13519173860549927,
-0.37180712819099426,
-0.1584729552268982,
0.3067670464515686,
0.03831341862678528,
0.049259353429079056,
-0.02023266814649105,
-0.11116168648004532,
-0.06237872317433357,
0.11663863807916641,
-0.0637492835521698,
-0.027723092585802078,
0.029112190008163452,
0.18450230360031128,
-0.12896549701690674,
-0.12880410254001617,
-0.019930658861994743,
-0.3006756007671356,
0.14278516173362732,
0.2558526396751404,
-0.21229803562164307,
-0.14507582783699036,
0.160494863986969,
-0.05866784602403641,
0.13476282358169556,
0.10027909278869629,
0.02117847464978695,
0.16170603036880493,
0.20756666362285614,
-0.12490072846412659,
-0.1955140382051468,
-0.24125513434410095,
0.1162613108754158,
0.20535756647586823,
-0.28466981649398804,
-0.18125392496585846,
-0.1251739263534546,
0.3193984627723694,
-0.025175906717777252,
-0.012555262073874474,
-0.0746537446975708,
-0.06850133836269379,
-0.08941134810447693,
-0.10163155943155289,
0.12167727947235107,
0.28491225838661194,
0.004183237906545401,
-0.10402026772499084,
-0.08133773505687714,
-0.036237142980098724,
0.32205691933631897,
0.23318332433700562,
-0.21278664469718933,
0.1630399227142334,
0.027554750442504883,
-0.08535659313201904,
0.10656759142875671,
0.13036225736141205,
-0.04474310949444771,
0.05277382209897041,
0.11262839287519455,
0.2878451347351074,
0.08006077259778976,
-0.022714292630553246,
0.16714677214622498,
-0.19405056536197662,
0.09614840894937515,
0.2309662401676178,
-0.19181548058986664,
0.1186455488204956,
0.023082803934812546,
-0.14577579498291016,
0.07970079034566879,
0.03448237478733063,
-0.10444816946983337,
-0.03872585669159889,
-0.21999363601207733,
0.15981629490852356,
0.00016904882795643061,
0.11688631027936935,
-0.03914085030555725,
0.035076241940259933,
-0.22688476741313934,
-0.009605727158486843,
0.254208505153656,
-0.03641726076602936,
-0.12129610776901245,
-0.11542560160160065,
0.08768466114997864,
0.16807717084884644,
0.013724288903176785,
-0.002580962609499693,
0.05034960061311722,
0.2489612102508545,
-0.13152086734771729,
0.1847282350063324,
-0.19840964674949646,
0.15908262133598328,
-0.06008436158299446,
0.00962847750633955,
0.001821886864490807,
-0.10174743831157684,
0.3122892677783966,
-0.09498137980699539,
0.013372127898037434,
-0.07565680891275406,
0.009205481968820095,
-0.2833395004272461,
-0.01901700161397457,
-0.11398576200008392,
0.003683555405586958,
0.1447017788887024,
-0.004850460682064295,
0.015954047441482544,
-0.10265742242336273,
-0.15094691514968872,
-0.0622025765478611,
-0.15594680607318878,
0.04585203155875206,
-0.35629594326019287,
0.05056404694914818,
-0.012652122415602207,
-0.17316514253616333,
-0.05009042099118233,
-0.096428282558918,
0.2123197466135025,
-0.04212750494480133,
-0.06531916558742523,
-0.16988909244537354,
-0.05629685893654823,
-0.016277384012937546,
0.008432251401245594,
-0.24854254722595215,
0.08053019642829895,
0.22939227521419525,
-0.10830922424793243,
0.2857166528701782,
0.2934347093105316,
-0.12800967693328857,
-0.20602379739284515,
-0.08567319810390472,
0.03406960517168045,
-0.30522626638412476,
0.026169948279857635,
-0.3413246273994446,
-0.0753621757030487,
-0.17566998302936554,
0.22339387238025665,
0.17417119443416595,
-0.19889797270298004,
-0.07723794132471085,
-0.10085061937570572,
-0.1812945306301117,
0.20797792077064514,
-0.05986781418323517,
-0.13866078853607178,
0.20906275510787964,
-0.0001534915209049359,
0.13446371257305145,
0.07138150185346603,
-0.029164377599954605,
0.07082381844520569,
0.047527287155389786,
-0.055814508348703384,
-0.21557319164276123,
-0.09202815592288971,
-0.11356064677238464,
-0.06625350564718246,
0.1604492962360382,
0.2596856653690338,
0.1263134628534317,
-0.09812522679567337,
-0.2259838879108429,
0.03867353871464729,
-0.2571469843387604,
0.3133407235145569,
-0.014423035085201263,
-0.14497192203998566,
-0.05067548155784607,
-0.06643366068601608,
-0.15803846716880798,
-0.05182221159338951,
-0.06472506374120712,
-0.07926148176193237,
-0.07495597749948502,
0.04760206118226051,
0.18092337250709534,
-0.02379778027534485,
-0.022534769028425217,
-0.014919600449502468,
-0.28389278054237366,
-0.059106357395648956,
-0.0476614311337471,
0.1608855426311493,
0.09891755133867264,
0.10676370561122894,
0.07042157649993896,
-0.09728013724088669,
-0.015687286853790283,
0.2177608609199524,
0.15307316184043884,
0.1761997491121292,
-0.17609567940235138,
0.07361181825399399,
0.12514151632785797,
-0.008310751058161259,
0.3001883924007416,
0.004022230859845877,
0.17842383682727814,
-0.003307654056698084,
0.10107921808958054,
-0.019793080165982246,
0.08552198857069016,
0.005795376840978861,
0.09020911902189255,
0.1405859738588333,
-0.12279349565505981,
-0.12083540111780167,
0.0030570081435143948,
0.02177099511027336,
-0.010599845089018345,
0.21146509051322937,
-0.05725986510515213,
-0.08559778332710266,
-0.004408993758261204,
0.075503408908844,
-0.08952712267637253,
-0.04528158903121948,
0.11279334872961044,
0.03347080945968628,
0.06090228259563446,
0.03161152824759483,
-0.11960580199956894,
-0.03400737792253494,
-0.008374979719519615,
0.17564736306667328,
0.09648891538381577,
0.016123512759804726,
0.008033542893826962,
0.034220241010189056,
-0.12081138789653778,
-0.20611274242401123,
-0.009392393752932549,
0.09121973067522049,
-0.0330469012260437,
0.16268575191497803,
0.1928507685661316,
-0.012228083796799183,
0.12282077968120575,
-0.18627439439296722,
0.0022044333163648844,
0.16282789409160614,
0.17291785776615143,
-0.032195985317230225,
0.3070780336856842,
-0.060688626021146774,
0.1494314819574356,
-0.01791105978190899,
0.07725879549980164,
0.2798747718334198,
0.04804452881217003,
-0.0517396442592144,
0.1726263463497162,
0.14712539315223694,
0.01204973179847002,
-0.20395419001579285,
0.04209388419985771,
0.15425395965576172,
-0.07555443793535233,
0.00400174455717206,
-0.09606236964464188,
0.004802503157407045,
0.06109998747706413,
-0.4197889268398285,
-0.1952018439769745,
0.011728872545063496,
-0.02510594204068184,
-0.07365647703409195,
0.03622544929385185,
-0.1403711438179016,
0.20205265283584595,
0.06578664481639862,
0.0056440564803779125,
0.15840373933315277,
0.2699611186981201,
-0.05605839192867279,
0.08345947414636612,
0.0033517787232995033,
0.14965948462486267,
-0.007186075672507286,
-0.1367129236459732,
-0.15477843582630157,
0.10635674744844437,
0.17187121510505676,
-0.01591266132891178,
-0.06561535596847534,
-0.04894740879535675,
-0.013306358829140663,
0.06892700493335724,
0.0628475770354271,
0.07009599357843399,
-0.1368965357542038,
0.03856494650244713,
-0.147682785987854,
-0.04582081362605095,
0.06668634712696075,
-0.15208913385868073,
0.2506265938282013,
-0.1434137374162674,
-0.03096872940659523,
0.07010021060705185,
-0.02346327342092991,
0.017206253483891487,
0.2035517692565918,
0.09819336980581284,
0.15874360501766205,
0.22531504929065704,
0.05071408674120903,
0.02671244367957115,
-0.0782913789153099,
0.10816288739442825,
0.03257974609732628,
0.13331685960292816,
-0.01483428105711937,
-0.029463764280080795,
0.31933894753456116,
-0.10802717506885529,
0.13904693722724915,
0.05756045877933502,
0.09012900292873383,
-0.04555264115333557,
0.24936778843402863,
0.2349439263343811,
-0.04226703941822052,
-0.04609851539134979,
-0.02752612717449665,
-0.2135920226573944,
-0.03451252728700638,
0.18082331120967865,
0.008578497916460037,
-0.1075962483882904,
-0.048858169466257095,
-0.05539955943822861,
-0.1171509325504303,
-0.225102499127388,
-0.012593530118465424,
0.1342170089483261,
-0.027248414233326912,
-0.11306518316268921,
-0.19808202981948853,
0.36853262782096863,
0.1024804562330246,
-0.2207072228193283,
0.28717535734176636,
0.2636682987213135,
0.010240072384476662,
0.05461971089243889,
-0.10654595494270325,
0.14732235670089722,
-0.0017497822409495711,
0.03788207843899727,
-0.233485609292984,
0.08730463683605194,
-0.06917083263397217,
-0.08444591611623764,
0.10923988372087479,
0.029255583882331848,
0.09175599366426468,
-0.2591305077075958,
-0.048207838088274,
-0.04497341066598892,
0.014762550592422485,
0.11371005326509476,
-0.1874895840883255,
0.18147747218608856,
-0.10763834416866302,
-0.23406882584095,
0.029238484799861908,
0.17561075091362,
0.001139908330515027,
0.08539488911628723,
-0.35826772451400757,
0.016173679381608963,
0.023297062143683434,
0.2135370671749115,
-0.12220198661088943,
0.378423273563385,
0.008694957010447979,
0.1939908117055893,
-0.2650262415409088,
-0.08603889495134354,
0.2523796558380127,
-0.047062743455171585,
-0.09008672833442688,
0.21871322393417358,
0.012187487445771694,
-0.059561435133218765,
-0.17595839500427246,
-0.05132143571972847,
0.051593124866485596,
-0.012967482209205627,
0.05910688266158104,
0.17540183663368225,
-0.1936027854681015,
-0.02366654947400093,
-0.06518935412168503,
-0.08069148659706116,
0.14825154840946198,
0.028565486893057823,
0.22178301215171814,
-0.3510892391204834,
0.17834927141666412,
-0.06341371685266495,
-0.29940322041511536,
-0.3358756899833679,
-0.3298715054988861,
-0.112993985414505,
0.04589826613664627,
0.12869887053966522,
0.10728911310434341,
0.11596579849720001,
-0.012667251750826836,
0.1368463635444641,
0.10705649107694626,
0.1374381184577942,
0.13885875046253204,
-0.06679289788007736,
0.057501230388879776,
-0.2834536135196686,
-0.022386398166418076,
-0.03775181248784065,
0.19442448019981384,
-0.13183198869228363,
0.2277238667011261,
-0.09551367163658142,
-0.10023593157529831,
-0.15409360826015472,
0.19119735062122345,
0.11706686019897461,
0.18356628715991974,
0.041403189301490784,
0.21074311435222626,
0.2634342610836029,
-0.15599215030670166,
0.06916218996047974,
0.3196212351322174,
0.13643592596054077,
-0.4842510521411896,
-0.03219136595726013,
-0.1926642209291458,
0.09023123234510422,
-0.01264333724975586,
-0.11304456740617752,
-0.09803231805562973,
0.07208211719989777,
0.0010039531625807285,
-0.005001451354473829,
-0.0615084245800972,
-0.018494674935936928,
0.043843116611242294,
-0.020055148750543594,
-0.19133567810058594,
0.3750864267349243,
-0.11413023620843887,
0.05934739112854004,
-0.08597278594970703,
-0.033103857189416885,
0.1370047777891159,
-0.024598799645900726,
0.10095319151878357,
0.22024694085121155,
-0.20864713191986084,
0.14436312019824982,
-0.2652606964111328,
0.0749993547797203,
-0.07578790932893753,
0.08957143127918243,
-0.04550648853182793,
0.09430991858243942,
0.1770961433649063,
0.026932811364531517,
0.35545116662979126,
-0.1963101476430893,
0.004847188014537096,
-0.13902775943279266,
-0.03047163225710392,
-0.07337333261966705,
0.12963852286338806,
0.013094085268676281,
0.0024356385692954063,
0.26791447401046753,
-0.01755835860967636,
0.1771666407585144,
-0.02451411448419094,
0.016735436394810677,
-0.09397701919078827,
0.0003644783573690802,
-0.26383158564567566,
-0.1416129171848297,
0.10583208501338959,
-0.011734933592379093,
0.006050197873264551,
-0.18905414640903473,
-0.028644749894738197,
-0.12029892951250076,
-0.11654075235128403,
0.053861103951931,
-0.09911804646253586,
-0.10839547216892242,
0.09789644926786423,
0.06888756155967712,
-0.18229612708091736,
-0.012893146835267544,
0.03788039833307266,
-0.12897536158561707,
0.033688414841890335,
0.061756327748298645,
-0.13020293414592743,
0.1835215836763382,
0.04681244120001793,
-0.007196131628006697,
-0.12556828558444977,
-0.0623711459338665,
-0.21871531009674072,
-0.06565908342599869,
0.10490372776985168,
-0.09376303106546402,
-0.009103569202125072,
0.03836183622479439,
0.13552376627922058,
-0.23303352296352386,
0.2156992256641388,
-0.008176414296030998,
0.10828062146902084
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. individuals with PS , most commonly in late childhood or adolescence. As with other disease manifestations, this can progress with startling rapidity. It commonly manifests by reduced exercise tolerance or as an incidental finding from chest imaging.Dysmorphic facial features typically evolve during childhood and are not obvious at birth. Reported facial features include dolichocephaly, long face, downslanting palpebral fissures, and/or minor ptosis, depressed nasal bridge, wide or anteverted nares, and open mouth at rest.Psychosocial issues. In addition to functional compromise, the skeletal and connective tissue overgrowth of PS can result in disfigurement for some individuals, a significant concern for many families . This condition is progressive and the degree of severity varies widely among individuals, creating uncertainty for both clinicians and families. Coping with an ultra-rare and chronic condition like PS poses challenges for many individuals and families.Prognosis is based on the location and degree of the overgrowth present in the | [
-0.015329131856560707,
0.0814475491642952,
-0.006661137565970421,
-0.35013559460639954,
0.0269300676882267,
-0.10335723310709,
-0.12596191465854645,
-0.14401768147945404,
-0.0968870148062706,
0.014430675655603409,
0.0910835936665535,
0.10379420220851898,
0.1203930452466011,
-0.021654361858963966,
-0.14460571110248566,
-0.01197937410324812,
-0.07324836403131485,
-0.00900373887270689,
-0.08303559571504593,
0.01795227639377117,
0.016259120777249336,
-0.06851097196340561,
-0.17564761638641357,
0.04843444377183914,
-0.04661034420132637,
-0.16231673955917358,
0.15532255172729492,
0.23419420421123505,
-0.05472227931022644,
-0.02449963428080082,
0.10438434034585953,
-0.02453094720840454,
-0.11181161552667618,
-0.15718941390514374,
0.24687999486923218,
-0.12331828474998474,
-0.0484047457575798,
0.032653842121362686,
0.09314204752445221,
-0.06647450476884842,
-0.08147641271352768,
-0.07786271721124649,
-0.08549883961677551,
-0.25444087386131287,
0.45030754804611206,
0.038124457001686096,
-0.032827675342559814,
0.18753601610660553,
0.23838119208812714,
0.04760058969259262,
0.14232109487056732,
-0.1341613084077835,
0.3113813102245331,
-0.012210415676236153,
0.14141513407230377,
-0.09693481773138046,
0.018465416505932808,
-0.13821102678775787,
-0.27715572714805603,
0.0458202138543129,
0.3121276795864105,
-0.0086499759927392,
0.2591235935688019,
-0.359379380941391,
0.15172217786312103,
-0.15861500799655914,
-0.04041292890906334,
0.1458972692489624,
0.09966196119785309,
-0.032772090286016464,
0.44676950573921204,
-0.11720748990774155,
-0.03240831941366196,
-0.13574546575546265,
0.005308146588504314,
-0.20572684705257416,
0.13622987270355225,
-0.11996658891439438,
0.007394325453788042,
-0.096342533826828,
-0.02419353276491165,
0.10053559392690659,
-0.01649685949087143,
0.03510613739490509,
-0.35606881976127625,
-0.15539948642253876,
-0.10011153668165207,
0.05653955787420273,
0.040251314640045166,
-0.08065522462129593,
0.09371516853570938,
-0.21546661853790283,
0.01866215281188488,
-0.030321577563881874,
0.3140885829925537,
0.040479376912117004,
0.20134159922599792,
-0.0077906157821416855,
-0.08269605785608292,
-0.08969870954751968,
0.022886062040925026,
0.2316172868013382,
-0.034988000988960266,
0.04706834256649017,
-0.009560413658618927,
-0.14106686413288116,
-0.0813908725976944,
0.16650094091892242,
0.0023016498889774084,
0.20641085505485535,
-0.026396598666906357,
-0.12852472066879272,
-0.018286997452378273,
-0.16677796840667725,
-0.23227928578853607,
-0.06194524094462395,
0.021539323031902313,
-0.024762945249676704,
-0.17209626734256744,
-0.12183429300785065,
0.12676963210105896,
-0.1811825931072235,
0.11745284497737885,
0.09180720150470734,
0.08665556460618973,
0.07291533797979355,
0.021137412637472153,
-0.08190923184156418,
0.05553026869893074,
-0.11190441995859146,
0.15625110268592834,
-0.03806125745177269,
-0.09320278465747833,
-0.40753108263015747,
0.13927412033081055,
0.1624530851840973,
0.031065599992871284,
-0.25048524141311646,
0.09769120067358017,
0.14066961407661438,
0.20154444873332977,
0.047276679426431656,
0.4640451669692993,
0.08270672708749771,
0.31911540031433105,
-0.05781607702374458,
0.04907848313450813,
0.09712819755077362,
0.11409718543291092,
-0.040441304445266724,
0.3257147967815399,
-0.07056950777769089,
0.020262734964489937,
-0.0279888566583395,
-0.08712352812290192,
-0.1228329986333847,
-0.012860879302024841,
0.004151436034590006,
-0.13676322996616364,
-0.009575963951647282,
-0.0895829126238823,
-0.09046235680580139,
0.007656787987798452,
-0.2189398556947708,
-0.11593224108219147,
0.04387841001152992,
0.013232359662652016,
-0.2913719117641449,
0.09678909927606583,
0.008603982627391815,
-0.20344266295433044,
0.263825386762619,
-0.11711989343166351,
0.08614858239889145,
-0.13253192603588104,
0.12052509188652039,
0.14159265160560608,
0.10067541897296906,
-0.09357327967882156,
0.054970551282167435,
0.147302508354187,
0.07614067196846008,
-0.23845985531806946,
-0.33877819776535034,
0.018687548115849495,
-0.26315611600875854,
0.07417427003383636,
0.30057069659233093,
-0.2342810332775116,
0.013827399350702763,
0.09971487522125244,
-0.02327709086239338,
-0.16913585364818573,
0.15558044612407684,
-0.11310397833585739,
-0.45608463883399963,
0.04828803613781929,
-0.131047785282135,
0.021698759868741035,
0.12487047165632248,
0.24588942527770996,
-0.05084861069917679,
0.025802941992878914,
-0.013395980931818485,
0.06638485938310623,
0.21103423833847046,
0.1595703810453415,
-0.20974381268024445,
0.09770435839891434,
0.025269687175750732,
-0.15004681050777435,
0.3852258622646332,
-0.24069955945014954,
-0.0812351331114769,
0.1664775311946869,
-0.08423905819654465,
-0.07269216328859329,
-0.222188338637352,
-0.14205573499202728,
0.20781995356082916,
-0.26255878806114197,
0.16339556872844696,
-0.10950987786054611,
-0.04233745113015175,
-0.27727195620536804,
0.1504671424627304,
-0.13309402763843536,
-0.08418929576873779,
-0.011312705464661121,
-0.016658026725053787,
-0.11796461790800095,
0.12156614661216736,
-0.049822866916656494,
0.17751561105251312,
0.13551613688468933,
-0.2630878686904907,
-0.2628977298736572,
0.15003901720046997,
-0.049740858376026154,
0.14559794962406158,
-0.1252155750989914,
-0.18092671036720276,
-0.0854485034942627,
-0.039384543895721436,
-0.09300851076841354,
0.0537448450922966,
0.13132894039154053,
0.10493075847625732,
-0.10604621469974518,
-0.10467012226581573,
0.06110595539212227,
-0.3267039358615875,
0.12119793891906738,
0.156951904296875,
-0.11068008095026016,
-0.1572382003068924,
0.20869311690330505,
0.09501232951879501,
0.09742891788482666,
-0.05991096794605255,
0.08946318924427032,
0.18899153172969818,
0.20347993075847626,
0.04528846591711044,
-0.3525807857513428,
-0.2713611423969269,
-0.02405555360019207,
0.2362508475780487,
-0.010484741069376469,
-0.1282402127981186,
-0.12791679799556732,
0.3051905632019043,
-0.042830195277929306,
-0.0028449934907257557,
-0.05345388129353523,
-0.04782358184456825,
-0.042100440710783005,
-0.002562497276812792,
0.08829282224178314,
0.18460401892662048,
0.1172095313668251,
-0.08340177685022354,
-0.16350439190864563,
0.005794656928628683,
0.39422181248664856,
0.11409182101488113,
-0.30639538168907166,
0.2994178533554077,
0.1399562656879425,
-0.11278734356164932,
-0.029137402772903442,
0.09729935228824615,
0.029109898954629898,
0.010497692041099072,
0.1088947206735611,
0.1531895399093628,
-0.0036923892330378294,
-0.046036142855882645,
0.42521822452545166,
-0.11695478856563568,
0.09047766029834747,
0.08290107548236847,
0.009355910122394562,
-0.02956751361489296,
0.10481084138154984,
-0.13779312372207642,
0.1216105967760086,
0.038672443479299545,
-0.018729591742157936,
-0.028043797239661217,
-0.12624017894268036,
0.12661996483802795,
0.04132696986198425,
0.1071384847164154,
0.01323634572327137,
0.03453058749437332,
-0.2509932518005371,
0.098424531519413,
0.23700600862503052,
0.008506091311573982,
-0.006359852384775877,
-0.12083857506513596,
-0.028347741812467575,
0.06129080802202225,
-0.06646525859832764,
0.04404221102595329,
-0.08229628950357437,
0.17862693965435028,
-0.2006077617406845,
0.26239389181137085,
-0.05416513979434967,
0.1870746612548828,
-0.07732006162405014,
-0.16602353751659393,
0.08458714932203293,
-0.28235843777656555,
0.08484389632940292,
-0.06139637529850006,
-0.0687684714794159,
-0.018623294308781624,
-0.09646616876125336,
-0.22975729405879974,
-0.03544870391488075,
-0.32660695910453796,
-0.008135451935231686,
0.12438256293535233,
-0.047045815736055374,
0.014285992830991745,
0.0867258757352829,
-0.31982308626174927,
-0.006298386957496405,
-0.08140327036380768,
-0.09737692028284073,
-0.2657599449157715,
0.11616455018520355,
-0.10928720235824585,
-0.10369927436113358,
-0.030244823545217514,
-0.012894763611257076,
0.1321621984243393,
-0.1057819202542305,
-0.08381319046020508,
-0.0775587186217308,
0.11367322504520416,
-0.019317584112286568,
0.08748076111078262,
-0.33004531264305115,
0.14468640089035034,
0.07797598093748093,
-0.169362410902977,
0.23792190849781036,
0.18082989752292633,
-0.04583527520298958,
-0.0923430547118187,
-0.10558312386274338,
-0.0583549328148365,
-0.28604185581207275,
0.09854958206415176,
-0.08887399733066559,
-0.09090382605791092,
-0.16579900681972504,
0.22567342221736908,
0.3638018071651459,
-0.2501193583011627,
-0.07889844477176666,
-0.05360773950815201,
-0.28387579321861267,
0.12561051547527313,
0.05579792335629463,
-0.16185669600963593,
0.09909845143556595,
0.13898605108261108,
0.07709567993879318,
0.13400334119796753,
-0.03879609704017639,
0.027725720778107643,
0.07604561001062393,
-0.016588948667049408,
-0.18568485975265503,
-0.0632537379860878,
-0.019220789894461632,
0.0025503397919237614,
0.022290155291557312,
0.16538996994495392,
0.1866215467453003,
-0.05905940756201744,
-0.21965500712394714,
0.07252219319343567,
-0.23874913156032562,
0.40308907628059387,
-0.13414205610752106,
-0.014566467143595219,
-0.06216113641858101,
-0.12701523303985596,
-0.08971615135669708,
-0.07762538641691208,
0.09899099916219711,
0.009672899730503559,
0.09752225130796432,
-0.0913441926240921,
0.061952680349349976,
-0.07085711508989334,
0.1140453964471817,
0.002936884295195341,
-0.1867690235376358,
-0.07901480048894882,
-0.10366126149892807,
0.17278555035591125,
0.15079879760742188,
0.20369087159633636,
0.023342899978160858,
-0.3220065236091614,
-0.052499450743198395,
0.2156444489955902,
-0.003387333592399955,
0.2131582498550415,
-0.06999360024929047,
-0.030691012740135193,
0.14928613603115082,
0.008286855183541775,
0.16395004093647003,
0.0006895369733683765,
0.09265580773353577,
-0.04140154644846916,
0.03617049381136894,
0.12511800229549408,
0.03109060600399971,
0.024687372148036957,
0.023169666528701782,
0.13706375658512115,
0.02455649897456169,
0.029863590374588966,
0.08512426912784576,
0.13709424436092377,
0.11166087538003922,
0.0943366140127182,
-0.04238090291619301,
0.058595575392246246,
-0.11817725002765656,
0.08558718115091324,
-0.11965400725603104,
0.11170938611030579,
0.22285526990890503,
-0.17405620217323303,
-0.024829823523759842,
0.0205700546503067,
-0.2355549931526184,
0.11319605261087418,
-0.03944433853030205,
0.09789760410785675,
0.0030210211407393217,
0.02328692562878132,
-0.00808518473058939,
-0.050159357488155365,
-0.2635389268398285,
-0.12428023666143417,
0.13494166731834412,
0.03319859504699707,
-0.04464595764875412,
0.14699052274227142,
0.04690377041697502,
-0.07925184816122055,
0.06020864471793175,
-0.2172383815050125,
0.05952443927526474,
0.09190435707569122,
0.022335253655910492,
-0.03047558106482029,
0.18483871221542358,
-0.2676229178905487,
0.13201433420181274,
-0.0645664781332016,
0.08202957361936569,
0.34780630469322205,
0.0685785561800003,
-0.004926495254039764,
0.07182736694812775,
0.19952110946178436,
-0.08826448768377304,
-0.09713114798069,
0.035847291350364685,
0.18524053692817688,
-0.13925360143184662,
-0.040275607258081436,
-0.06167309731245041,
-0.002459743060171604,
0.10688934475183487,
-0.3532293736934662,
-0.1562606692314148,
-0.08648306876420975,
-0.009187107905745506,
0.0020575765520334244,
-0.029346348717808723,
-0.15536203980445862,
0.12251659482717514,
0.015133069828152657,
0.057097405195236206,
-0.039290547370910645,
0.15061695873737335,
-0.25339147448539734,
0.03218353912234306,
-0.04101208597421646,
0.1834886074066162,
-0.06783277541399002,
-0.1469389647245407,
-0.09319190680980682,
-0.039383310824632645,
0.09274640679359436,
0.08650995790958405,
-0.19165170192718506,
-0.007429391145706177,
-0.026083186268806458,
0.022822968661785126,
0.03286006301641464,
0.2115611582994461,
-0.22195322811603546,
0.16807958483695984,
-0.22630029916763306,
-0.07881912589073181,
0.10544305294752121,
-0.16811901330947876,
0.3182750642299652,
-0.013161089271306992,
-0.02591603994369507,
0.08902032673358917,
-0.042616043239831924,
0.06199322268366814,
0.18652436137199402,
-0.05300574004650116,
0.14909568428993225,
0.12220722436904907,
-0.012004654854536057,
0.00918966718018055,
-0.16200394928455353,
-0.0985059142112732,
-0.12400452792644501,
0.13766391575336456,
0.05743399262428284,
-0.032509882003068924,
0.2698126435279846,
-0.07387886196374893,
0.19143939018249512,
-0.07416088134050369,
0.02007603831589222,
-0.010866994969546795,
0.14459486305713654,
0.2295127511024475,
-0.030135182663798332,
-0.03798346221446991,
-0.021574966609477997,
0.02422788366675377,
0.0011881613172590733,
0.203253835439682,
-0.051411859691143036,
-0.1437472701072693,
-0.05332428589463234,
-0.09778404235839844,
-0.1198025494813919,
-0.23064568638801575,
-0.0051373811438679695,
0.14955243468284607,
-0.1015963926911354,
-0.13200007379055023,
-0.4047205150127411,
0.14884424209594727,
0.15275181829929352,
-0.2319573611021042,
0.1981850415468216,
0.3061869442462921,
0.027989789843559265,
0.04704447090625763,
-0.042043961584568024,
0.09655243158340454,
-0.03992510586977005,
0.05878209322690964,
-0.0651518851518631,
-0.003710497636348009,
0.0600021556019783,
0.005337459035217762,
0.016030194237828255,
0.08186296373605728,
0.07846944779157639,
-0.16283051669597626,
-0.00030007027089595795,
0.029287192970514297,
0.09291411936283112,
0.01206463947892189,
-0.1275591254234314,
-0.02332829125225544,
0.08742891252040863,
-0.1495286375284195,
-0.017780959606170654,
0.11966899037361145,
-0.009088755585253239,
0.08538437634706497,
-0.2530876696109772,
0.01689898781478405,
-0.0897388756275177,
0.3539518415927887,
-0.14099478721618652,
0.36759769916534424,
-0.08481836318969727,
0.08900486677885056,
-0.19371147453784943,
-0.3123149573802948,
0.1834285706281662,
0.03231531381607056,
0.011000369675457478,
0.19583086669445038,
-0.0016436435980722308,
0.1730715036392212,
-0.0349799282848835,
-0.0144288819283247,
-0.03270990028977394,
-0.1394146978855133,
-0.014827504754066467,
0.22180207073688507,
-0.20928038656711578,
0.020902195945382118,
-0.08325226604938507,
0.04426927864551544,
0.20320849120616913,
0.22058242559432983,
0.17860233783721924,
-0.2513538897037506,
0.10080993920564651,
-0.07181442528963089,
-0.22824479639530182,
-0.2856263816356659,
-0.302901953458786,
-0.06920789927244186,
0.19626769423484802,
0.0643322765827179,
0.10119245946407318,
0.2614400088787079,
-0.08171971887350082,
0.1880679428577423,
-0.01605876348912716,
0.2111293226480484,
-0.10756855458021164,
-0.0675329715013504,
0.1044156476855278,
-0.07619151473045349,
-0.06269507855176926,
0.003427108284085989,
0.23032993078231812,
-0.12365483492612839,
0.20723247528076172,
-0.20142318308353424,
-0.025632260367274284,
-0.3464195728302002,
0.1460372656583786,
0.19078710675239563,
0.10332385450601578,
-0.05964510887861252,
0.0635175034403801,
0.2023690938949585,
-0.17523042857646942,
0.011405900120735168,
0.318778932094574,
0.05423687770962715,
-0.4281747341156006,
-0.08590956032276154,
-0.0939759761095047,
0.0842965617775917,
0.07382242381572723,
-0.1282454878091812,
-0.03693204000592232,
0.03318887576460838,
0.0134721165522933,
0.06831689178943634,
-0.18854138255119324,
0.05583881959319115,
0.028282368555665016,
-0.0713018849492073,
-0.27924540638923645,
0.3451107144355774,
0.05103597790002823,
-0.07470691949129105,
0.05682120472192764,
-0.12118545174598694,
0.04447482153773308,
-0.008361493237316608,
0.027678877115249634,
0.1606910228729248,
0.0015805074945092201,
0.17646712064743042,
-0.19540157914161682,
0.11787017434835434,
-0.23425106704235077,
0.18195199966430664,
-0.03587785363197327,
0.12297386676073074,
0.24355806410312653,
-0.03279722481966019,
0.2376450002193451,
-0.1670960783958435,
0.06031588092446327,
-0.13753339648246765,
-0.08567970246076584,
-0.05706755816936493,
0.14101730287075043,
0.03528270125389099,
-0.03298863396048546,
0.18784601986408234,
-0.009996545501053333,
0.08449186384677887,
0.020077915862202644,
0.07394035905599594,
0.04619855061173439,
0.07262503355741501,
-0.20131313800811768,
-0.22068117558956146,
0.08124566823244095,
-0.08508788794279099,
-0.11215326189994812,
0.04600594937801361,
-0.09956689924001694,
-0.08919602632522583,
-0.31964433193206787,
0.10454510152339935,
-0.14590908586978912,
-0.05350441485643387,
0.07992884516716003,
0.11363771557807922,
-0.14595869183540344,
0.08559498935937881,
0.04580710828304291,
0.00034228438744321465,
0.043827302753925323,
-0.03233953192830086,
0.008584367111325264,
0.3001026511192322,
0.1913742572069168,
-0.016117287799715996,
0.011379064060747623,
-0.16312982141971588,
-0.07594984024763107,
-0.12206114083528519,
0.06756457686424255,
-0.08092253655195236,
-0.20068833231925964,
0.1186254546046257,
0.09173395484685898,
-0.23486179113388062,
0.28661099076271057,
0.051765650510787964,
0.026060564443469048
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. everted nares, and open mouth at rest.Psychosocial issues. In addition to functional compromise, the skeletal and connective tissue overgrowth of PS can result in disfigurement for some individuals, a significant concern for many families . This condition is progressive and the degree of severity varies widely among individuals, creating uncertainty for both clinicians and families. Coping with an ultra-rare and chronic condition like PS poses challenges for many individuals and families.Prognosis is based on the location and degree of the overgrowth present in the individual and the presence or absence of significant complications such as bullous pulmonary disease, hemimegencephaly, and pulmonary embolism. The disorder is highly variable. While it is difficult to calculate life expectancy, it is clear that there are many more children with PS than adults. With appropriate management, mildly affected individuals have an excellent prognosis.Genotype-Phenotype CorrelationsPS is known to be caused by only a single, mosaic pathogenic variant (p.Glu17Lys) in AKT1. A | [
-0.1807422786951065,
-0.013263150118291378,
0.10701271891593933,
-0.380092978477478,
0.07990376651287079,
0.03301376476883888,
-0.12817522883415222,
-0.17834676802158356,
-0.11285623162984848,
0.05142379179596901,
0.04418707266449928,
-0.0073029641062021255,
-0.027111075818538666,
0.009554154239594936,
-0.10752928256988525,
0.22621722519397736,
0.03657441958785057,
0.060214798897504807,
0.03093954175710678,
0.058445051312446594,
-0.0743626281619072,
-0.036242034286260605,
-0.015151417814195156,
0.1784863919019699,
0.0952700823545456,
-0.3163231313228607,
0.14625908434391022,
-0.09136243909597397,
-0.06700722873210907,
-0.10999026894569397,
-0.1043911948800087,
0.04634565860033035,
0.024670597165822983,
-0.17647655308246613,
-0.006115728057920933,
-0.27453598380088806,
-0.06279256939888,
0.07727307826280594,
0.0256748478859663,
0.14620180428028107,
0.03387303650379181,
0.07777607440948486,
0.05893978103995323,
-0.10668953508138657,
0.1984090507030487,
-0.18329545855522156,
0.12581701576709747,
0.017174065113067627,
0.0854535773396492,
0.16233180463314056,
0.12396354973316193,
-0.11545658856630325,
0.11136019229888916,
-0.17778481543064117,
0.12459435313940048,
-0.19536009430885315,
-0.013172773644328117,
-0.23209844529628754,
-0.1565716415643692,
0.023431403562426567,
0.16496257483959198,
0.023971952497959137,
0.11612965166568756,
-0.3269091248512268,
0.10527770966291428,
-0.12716397643089294,
-0.1820203810930252,
0.08259346336126328,
0.13902099430561066,
-0.016373908147215843,
0.2062280923128128,
-0.07487012445926666,
-0.0044425190426409245,
-0.04244566708803177,
-0.020903846248984337,
-0.07904522120952606,
-0.009290159679949284,
-0.12578637897968292,
0.07955711334943771,
-0.07230731844902039,
-0.04256783798336983,
-0.05973607674241066,
-0.2178865671157837,
0.13043341040611267,
-0.27307283878326416,
-0.1903347223997116,
0.10840590298175812,
0.04022570326924324,
-0.09736271947622299,
-0.05700254440307617,
-0.07675927877426147,
-0.030439816415309906,
-0.07488302886486053,
0.10563083738088608,
0.2083919495344162,
-0.09189973026514053,
0.21152211725711823,
0.1594693660736084,
-0.2360694706439972,
-0.04584379121661186,
0.10348619520664215,
0.12853437662124634,
-0.13439024984836578,
0.07168975472450256,
0.11849568039178848,
0.0348333977162838,
-0.14154349267482758,
0.010871758684515953,
-0.015880517661571503,
-0.039417605847120285,
0.09206830710172653,
-0.06970802694559097,
0.1547829657793045,
-0.02935146540403366,
-0.2909071743488312,
-0.158441960811615,
-0.0875752791762352,
-0.06875724345445633,
-0.0881936103105545,
-0.04802820831537247,
-0.05402010306715965,
0.09236402809619904,
0.1156172975897789,
-0.12549619376659393,
0.1277116984128952,
0.021462759003043175,
0.285031795501709,
-0.1290687471628189,
-0.08755060285329819,
-0.19921055436134338,
0.1597212255001068,
-0.18449629843235016,
-0.09284698218107224,
-0.19350863993167877,
0.21007417142391205,
0.17190812528133392,
-0.013032802380621433,
-0.08861708641052246,
0.1157514676451683,
0.13030867278575897,
0.12619398534297943,
0.11497070640325546,
0.1739945411682129,
0.14681193232536316,
0.022787820547819138,
0.09528188407421112,
0.28503069281578064,
0.05889376997947693,
0.11661083996295929,
-0.11351114511489868,
0.04120829701423645,
-0.03215119242668152,
0.18122124671936035,
0.04155560955405235,
0.002366978209465742,
-0.028620710596442223,
-0.022866755723953247,
0.24666215479373932,
-0.19497014582157135,
0.06040120869874954,
0.11388593167066574,
-0.06124940887093544,
-0.17161622643470764,
0.027675682678818703,
-0.01700049825012684,
0.051806528121232986,
-0.06143634021282196,
-0.14758962392807007,
0.14320580661296844,
-0.01849926821887493,
0.03972380608320236,
0.08516307920217514,
-0.02009345404803753,
0.19294872879981995,
-0.0196347888559103,
0.12084436416625977,
-0.029323391616344452,
-0.029630647972226143,
0.05075798183679581,
0.09202563017606735,
0.1520262062549591,
-0.11606495082378387,
-0.0763268768787384,
-0.19997063279151917,
-0.03469051420688629,
-0.06927048414945602,
0.021699901670217514,
0.06319217383861542,
-0.16194981336593628,
0.12695620954036713,
0.08916278183460236,
-0.04275045543909073,
-0.11519841849803925,
-0.05754489079117775,
-0.01415488962084055,
-0.4112986922264099,
-0.054002877324819565,
-0.003618532558903098,
0.059769317507743835,
-0.03015296906232834,
-0.02896292880177498,
-0.060575854033231735,
0.08587343245744705,
0.030516449362039566,
0.17346270382404327,
0.0727192685008049,
0.0285031795501709,
-0.22875022888183594,
0.21506348252296448,
0.0704222023487091,
-0.09121821820735931,
0.3366469740867615,
-0.29155200719833374,
0.0684075728058815,
-0.10112632811069489,
0.039429377764463425,
-0.10303967446088791,
-0.24455760419368744,
-0.18717148900032043,
-0.0013578104553744197,
-0.25180187821388245,
0.09301993250846863,
-0.03214432671666145,
-0.0718822106719017,
-0.17055588960647583,
-0.05827707424759865,
-0.01391520444303751,
-0.17969758808612823,
0.22358426451683044,
-0.04815736040472984,
-0.18390075862407684,
-0.002278194995597005,
-0.007255386095494032,
0.24789445102214813,
0.05195511132478714,
-0.1874324232339859,
-0.11179269850254059,
0.3007184565067291,
-0.01913352683186531,
0.09131935238838196,
0.05564951151609421,
-0.039939459413290024,
0.04374515265226364,
0.11693862080574036,
0.028031600639224052,
0.046155188232660294,
0.026571158319711685,
0.16009636223316193,
-0.15920159220695496,
-0.1307198703289032,
-0.04304634779691696,
-0.368878036737442,
0.050396233797073364,
0.14619523286819458,
-0.3101460039615631,
-0.13211984932422638,
0.1121717020869255,
-0.06915275752544403,
0.19204428791999817,
0.06177086755633354,
0.05830066278576851,
0.10806255042552948,
0.24953819811344147,
-0.0641736388206482,
-0.22530749440193176,
-0.13552461564540863,
0.07669080048799515,
0.17316532135009766,
-0.21001416444778442,
-0.20154306292533875,
-0.027469785884022713,
0.26090914011001587,
-0.023043598979711533,
-0.054674919694662094,
-0.14537562429904938,
-0.016088414937257767,
0.0916828140616417,
0.06673967093229294,
0.10203074663877487,
0.18387030065059662,
0.09459544718265533,
0.015671927481889725,
-0.03676287457346916,
0.07841405272483826,
0.2925689220428467,
0.15519456565380096,
-0.3102567791938782,
0.1031750738620758,
-0.004227382596582174,
-0.031790267676115036,
-0.012058203108608723,
0.11924479156732559,
0.038787905126810074,
0.0648089200258255,
0.1417013257741928,
0.35245612263679504,
0.04117346554994583,
-0.024363109841942787,
0.06770479679107666,
-0.13830089569091797,
0.018759815022349358,
0.3236561715602875,
-0.0944974422454834,
-0.0023127885069698095,
0.0711960718035698,
-0.05074424669146538,
0.07459135353565216,
-0.23335538804531097,
0.07529789954423904,
-0.04456974193453789,
-0.13548775017261505,
0.033218346536159515,
0.032199230045080185,
0.14612789452075958,
-0.09354701638221741,
0.1046895757317543,
-0.08757536113262177,
0.08204562216997147,
0.21368741989135742,
0.027556970715522766,
-0.0636482685804367,
-0.03469926863908768,
0.06416375190019608,
0.04856443777680397,
0.09256468713283539,
0.02078225277364254,
-0.0939553827047348,
0.30398303270339966,
0.023121023550629616,
0.04117947816848755,
0.01022500079125166,
0.020358769223093987,
-0.18471048772335052,
0.14203312993049622,
0.15457934141159058,
-0.054559219628572464,
0.02141696587204933,
-0.20189611613750458,
-0.020012259483337402,
0.024556193500757217,
-0.0019233039347454906,
-0.18689563870429993,
-0.21706895530223846,
0.030845267698168755,
0.03864998742938042,
0.21103790402412415,
-0.029395906254649162,
0.051639873534440994,
-0.09244134277105331,
-0.04037250205874443,
0.023283392190933228,
-0.25608089566230774,
-0.012259289622306824,
-0.343676894903183,
0.27642565965652466,
-0.013113453984260559,
-0.004106976091861725,
0.030993985012173653,
-0.07514967769384384,
0.21335139870643616,
-0.0392928384244442,
-0.06529947370290756,
-0.22080087661743164,
-0.08310425281524658,
0.07775279134511948,
-0.17108021676540375,
-0.0899016335606575,
0.08105187118053436,
0.2930830419063568,
-0.049589332193136215,
0.3241339921951294,
0.16287140548229218,
-0.005699573550373316,
0.02932630479335785,
-0.03926385939121246,
0.20901690423488617,
-0.15687121450901031,
0.14766104519367218,
-0.26065593957901,
-0.1915571689605713,
0.07719627767801285,
0.08251413702964783,
0.11117282509803772,
-0.28085845708847046,
-0.12181048095226288,
-0.14504224061965942,
-0.1084849089384079,
0.16767533123493195,
0.04372255504131317,
-0.08469448238611221,
0.1012759581208229,
0.021141372621059418,
0.07263512164354324,
0.08671876043081284,
-0.022727075964212418,
0.034310437738895416,
0.08226112276315689,
-0.22295533120632172,
-0.18013650178909302,
-0.12289363890886307,
-0.14927944540977478,
-0.0733138844370842,
0.1174844428896904,
0.35570767521858215,
-0.0440552644431591,
0.06255777180194855,
-0.029859527945518494,
0.012032270431518555,
-0.25254127383232117,
0.2628229558467865,
-0.08565693348646164,
-0.11814717948436737,
-0.06666773557662964,
-0.07733852416276932,
-0.07526903599500656,
-0.10196937620639801,
-0.059365835040807724,
0.06563010811805725,
-0.12700346112251282,
-0.05397122725844383,
0.16994917392730713,
0.11459522694349289,
-0.018738409504294395,
-0.02177547663450241,
-0.3726922869682312,
-0.028735265135765076,
-0.10272906720638275,
0.1642380654811859,
-0.019247252494096756,
0.28807777166366577,
0.13313709199428558,
-0.0909530371427536,
-0.047232478857040405,
0.13984279334545135,
-0.045893698930740356,
0.23734742403030396,
-0.018044747412204742,
0.1974429190158844,
0.04249672591686249,
0.03867027536034584,
0.23978841304779053,
0.05985509231686592,
0.2692575752735138,
0.11275928467512131,
0.05052826181054115,
0.06167303025722504,
0.12562301754951477,
0.0917859748005867,
0.15491552650928497,
0.25438782572746277,
-0.06119554862380028,
-0.0854102075099945,
0.05113504081964493,
-0.03839939087629318,
0.037211187183856964,
0.22201959788799286,
-0.05774476006627083,
-0.1198737770318985,
0.0448053777217865,
0.04877077788114548,
-0.08002665638923645,
0.025124764069914818,
0.22790023684501648,
-0.05881800502538681,
0.08409778028726578,
0.041724320501089096,
-0.09042885899543762,
0.06706083565950394,
0.009573121555149555,
0.05075455829501152,
0.07279951125383377,
-0.024597162380814552,
-0.09081795066595078,
0.03889049217104912,
-0.06848672777414322,
-0.13693690299987793,
-0.037475790828466415,
0.029776539653539658,
-0.15432658791542053,
0.09353350847959518,
0.1755238175392151,
0.12633685767650604,
0.08868161588907242,
-0.12479862570762634,
0.10145983099937439,
0.15461485087871552,
0.21795886754989624,
-0.03341427445411682,
0.359648734331131,
-0.10974002629518509,
0.11242058128118515,
0.12672170996665955,
0.11411542445421219,
0.4045342206954956,
0.08238384127616882,
0.028016822412610054,
0.2392657846212387,
-0.14054422080516815,
-0.006807238794863224,
-0.18433521687984467,
-0.0021456151735037565,
0.13313958048820496,
-0.028294038027524948,
0.047077104449272156,
0.06479356437921524,
0.03885326907038689,
0.05116785317659378,
-0.19946232438087463,
-0.05653465539216995,
0.0951324850320816,
-0.03882123529911041,
-0.05068787559866905,
-0.006051057018339634,
-0.2401243895292282,
0.07563035935163498,
-0.05851569399237633,
-0.027615169063210487,
0.17099201679229736,
0.15873001515865326,
0.08531906455755234,
0.06417379528284073,
-0.1300496608018875,
0.05775091424584389,
-0.01867961511015892,
-0.13263216614723206,
-0.1930169016122818,
-0.05379452928900719,
0.12926973402500153,
-0.11055461317300797,
-0.08117249608039856,
-0.0841025784611702,
0.037778664380311966,
0.04776841402053833,
0.006144870072603226,
0.12424786388874054,
-0.04589157924056053,
0.18668214976787567,
-0.05460494011640549,
-0.24492838978767395,
0.02811387926340103,
-0.14693231880664825,
0.06899742782115936,
0.04139094054698944,
0.014654670841991901,
-0.1765112280845642,
0.05739160254597664,
0.10144180804491043,
0.025721147656440735,
0.23504476249217987,
0.1521255075931549,
0.11696718633174896,
0.051150429993867874,
0.019876668229699135,
-0.1128859892487526,
0.1562151312828064,
0.05906316637992859,
0.1144123300909996,
-0.03802257776260376,
-0.033949512988328934,
0.1395931988954544,
-0.0863628163933754,
0.027432212606072426,
-0.011184226721525192,
-0.016227437183260918,
-0.029399899765849113,
0.23752954602241516,
0.16408847272396088,
-0.027494793757796288,
-0.045748934149742126,
-0.15900206565856934,
-0.1352733075618744,
-0.08760352432727814,
0.21714983880519867,
-0.0616099052131176,
-0.01481089647859335,
-0.0346650704741478,
-0.05119933933019638,
-0.12288054078817368,
-0.25405967235565186,
0.09240221977233887,
0.11390461027622223,
-0.18329842388629913,
-0.08442956954240799,
-0.1838938295841217,
0.14735859632492065,
0.060383398085832596,
-0.11406739056110382,
0.1482742428779602,
0.2837677299976349,
-0.06465919315814972,
-0.04890909045934677,
-0.10326670110225677,
0.1231841892004013,
0.03832916170358658,
-0.009586703032255173,
-0.028857754543423653,
0.20802831649780273,
-0.21808959543704987,
0.03766154125332832,
0.04041624069213867,
0.0434994138777256,
0.13761065900325775,
-0.17745186388492584,
-0.15020877122879028,
0.03551191836595535,
0.03583984076976776,
0.1818235069513321,
-0.41047054529190063,
0.20742760598659515,
0.11939533054828644,
-0.16037540137767792,
0.03472916781902313,
0.15698695182800293,
-0.0528627447783947,
0.24836896359920502,
-0.28332701325416565,
0.018892545253038406,
0.15799149870872498,
0.2488829791545868,
-0.0768706277012825,
0.3786129355430603,
0.035820625722408295,
0.18424749374389648,
-0.20457148551940918,
-0.0893353745341301,
0.14727911353111267,
-0.027300015091896057,
-0.08446765691041946,
0.14336764812469482,
0.034243371337652206,
-0.22935646772384644,
-0.10423875600099564,
-0.028847290202975273,
0.18777982890605927,
-0.05273757874965668,
0.14239810407161713,
-0.027366161346435547,
-0.18051554262638092,
-0.1492398977279663,
-0.007550360169261694,
-0.15438462793827057,
0.09670048207044601,
-0.13110654056072235,
0.04829661548137665,
-0.3660307824611664,
0.12822376191616058,
0.08130555599927902,
-0.15392285585403442,
-0.12460292875766754,
-0.21938391029834747,
-0.06160775199532509,
0.21340878307819366,
0.12939207255840302,
0.0846697986125946,
0.06554251164197922,
-0.008068723604083061,
0.19764620065689087,
0.13442786037921906,
-0.010205612517893314,
0.14078345894813538,
0.027705693617463112,
0.18417279422283173,
-0.08463586121797562,
0.010223764926195145,
0.010018697939813137,
0.15431515872478485,
0.036810144782066345,
0.2793351709842682,
-0.13999558985233307,
-0.08486007153987885,
-0.11473584920167923,
0.1329887956380844,
0.09189026057720184,
0.16205796599388123,
0.11011840403079987,
0.009202818386256695,
0.11080387979745865,
-0.07575646042823792,
0.05580312758684158,
0.3772989809513092,
-0.04778546839952469,
-0.28627318143844604,
-0.1282256841659546,
-0.12478677928447723,
0.14087647199630737,
-0.0759105384349823,
-0.0927223190665245,
-0.0932478979229927,
-0.004695340991020203,
-0.09002931416034698,
-0.0716320276260376,
-0.0842345580458641,
0.05251418054103851,
0.11201649904251099,
-0.02385815791785717,
-0.10976071655750275,
0.38932397961616516,
-0.16335244476795197,
-0.00829923152923584,
-0.0661502480506897,
-0.045639943331480026,
-0.022396516054868698,
-0.03837868198752403,
0.1428716778755188,
0.08299169689416885,
-0.22329182922840118,
0.12749913334846497,
-0.2375057488679886,
-0.003279557917267084,
0.10323391109704971,
0.009036113508045673,
-0.2709401845932007,
0.034864749759435654,
0.0023407116532325745,
-0.10636316239833832,
0.2869478464126587,
-0.13580745458602905,
-0.0012701730011031032,
-0.06590849161148071,
0.19783109426498413,
-0.010275824926793575,
0.09297186881303787,
-0.002402637153863907,
-0.10617586970329285,
0.2397943139076233,
0.08062097430229187,
0.0836409404873848,
-0.002233340637758374,
-0.029751230031251907,
0.05778108537197113,
-0.06118234619498253,
-0.2069098800420761,
-0.12918910384178162,
0.05696435272693634,
0.12811215221881866,
0.15745975077152252,
0.009726203046739101,
-0.08451236039400101,
-0.08206130564212799,
-0.1599491983652115,
0.02611110545694828,
-0.11947309970855713,
-0.09770391881465912,
0.03637826070189476,
0.15699654817581177,
0.05501580238342285,
-0.006962534971535206,
-0.1410071849822998,
-0.13804247975349426,
0.023975444957613945,
0.10132155567407608,
0.0474926196038723,
0.03140734136104584,
-0.0585646778345108,
0.077422596514225,
-0.3694114089012146,
-0.14374463260173798,
-0.1112142950296402,
0.04768195375800133,
0.078224778175354,
-0.17511402070522308,
-0.05681619420647621,
-0.02608613669872284,
0.1153920516371727,
-0.22903083264827728,
0.23352716863155365,
0.07350186258554459,
0.15964792668819427
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. the overgrowth present in the individual and the presence or absence of significant complications such as bullous pulmonary disease, hemimegencephaly, and pulmonary embolism. The disorder is highly variable. While it is difficult to calculate life expectancy, it is clear that there are many more children with PS than adults. With appropriate management, mildly affected individuals have an excellent prognosis.Genotype-Phenotype CorrelationsPS is known to be caused by only a single, mosaic pathogenic variant (p.Glu17Lys) in AKT1. A detailed autopsy study of an individual showed that while there was an overall correlation of variant levels with the presence of gross or histologic manifestations of overgrowth (hypertrophy or hyperplasia), this correlation was not tight nor absolute. Some tissues with overgrowth had no detectable variant, while other apparently unaffected tissues did harbor the variant. Clinicians should be cautious when assuming that a tissue or organ is unaffected by this disease.PenetranceIncomplete penetrance cannot be assessed in a mosaic genetic disorder that is not inherited | [
-0.09003501385450363,
-0.02552524209022522,
-0.015791427344083786,
-0.3576458990573883,
0.11136001348495483,
0.02838236279785633,
-0.01809520646929741,
-0.27377021312713623,
-0.061357978731393814,
-0.035807959735393524,
0.10757799446582794,
-0.029376892372965813,
-0.06021944433450699,
0.0438515730202198,
-0.18249452114105225,
0.2680693566799164,
-0.058807145804166794,
0.11744607239961624,
-0.0032571516931056976,
0.10634040087461472,
-0.09427464753389359,
-0.1530531793832779,
0.1682664155960083,
0.20645056664943695,
-0.00545643363147974,
-0.3293476998806,
0.1574423611164093,
-0.11535214632749557,
-0.06801072508096695,
-0.13909322023391724,
-0.042093679308891296,
-0.003103982424363494,
-0.06524836272001266,
-0.21125204861164093,
-0.10388112813234329,
-0.39085108041763306,
-0.15091852843761444,
-0.06785523891448975,
0.08112302422523499,
0.061876777559518814,
0.05469300225377083,
0.004552405793219805,
0.057134147733449936,
-0.035021137446165085,
0.2131589651107788,
-0.23236235976219177,
0.09039688110351562,
0.10229010134935379,
0.13628309965133667,
0.19388268887996674,
0.07748498767614365,
-0.04875156283378601,
0.09635785222053528,
-0.2560218274593353,
0.22224724292755127,
-0.15717071294784546,
0.0913422480225563,
-0.10513544827699661,
-0.21108286082744598,
0.016758602112531662,
0.06766066700220108,
0.047094911336898804,
0.11294586956501007,
-0.3565049171447754,
0.09463632851839066,
-0.13116046786308289,
-0.1695236712694168,
0.268045037984848,
0.08847636729478836,
0.018893470987677574,
0.11128397285938263,
-0.05817441642284393,
-0.025480253621935844,
-0.14712190628051758,
0.08020104467868805,
-0.10796397924423218,
0.11645310372114182,
-0.09424711763858795,
0.027299566194415092,
-0.120395228266716,
-0.048422522842884064,
-0.0952548086643219,
-0.283559113740921,
0.13031700253486633,
-0.12466330826282501,
-0.09348198026418686,
0.09921735525131226,
-0.09166219830513,
-0.04753674194216728,
-0.028599336743354797,
0.0041756355203688145,
-0.02675686404109001,
0.12946976721286774,
0.22643965482711792,
0.18769866228103638,
-0.053413815796375275,
0.1003369390964508,
0.10103808343410492,
-0.1811528503894806,
-0.006467504892498255,
0.1816609501838684,
0.1430874913930893,
-0.30494168400764465,
0.12416666746139526,
0.04846232011914253,
0.052487947046756744,
-0.07825055718421936,
0.07898876816034317,
0.020896289497613907,
-0.04640597105026245,
-0.05381820350885391,
-0.12618891894817352,
-0.06426306813955307,
0.01235442329198122,
-0.2647038698196411,
-0.22422921657562256,
-0.2168721705675125,
-0.0681636780500412,
-0.08399708569049835,
0.02767360396683216,
-0.0666031464934349,
0.09722398966550827,
0.017820440232753754,
0.06044694781303406,
0.06681258231401443,
-0.032182689756155014,
0.23707760870456696,
-0.14126503467559814,
0.07140960544347763,
-0.09802059829235077,
0.0603802464902401,
-0.09211932122707367,
0.031490545719861984,
-0.031926658004522324,
0.23191100358963013,
0.061794817447662354,
-0.06520631164312363,
0.028222450986504555,
0.10591248422861099,
0.10352703183889389,
0.1867617815732956,
0.10297256708145142,
0.20289024710655212,
0.09614058583974838,
-0.04231562465429306,
0.15678314864635468,
0.2141886055469513,
0.05626413971185684,
0.06805291026830673,
-0.16703622043132782,
0.077744260430336,
0.035527151077985764,
0.16058245301246643,
0.038165345788002014,
-0.06556220352649689,
-0.0019484589574858546,
0.0032239556312561035,
0.16556569933891296,
-0.18836039304733276,
-0.08739713579416275,
0.09837082028388977,
0.05113883689045906,
-0.06596925109624863,
-0.05587160959839821,
0.11270149797201157,
0.10274145007133484,
-0.06170544773340225,
-0.09173878282308578,
0.16357102990150452,
0.0063506849110126495,
0.00017471445607952774,
0.10187859833240509,
-0.0696970522403717,
0.13324479758739471,
-0.01656208746135235,
0.038235388696193695,
-0.13038606941699982,
-0.040967680513858795,
0.03820232301950455,
0.014126244001090527,
0.11870069801807404,
-0.0581047385931015,
-0.1089014858007431,
-0.22710499167442322,
-0.08069461584091187,
-0.026926197111606598,
-0.052567388862371445,
0.14416754245758057,
-0.16572624444961548,
0.09245692938566208,
0.095647893846035,
0.013672455213963985,
-0.06818124651908875,
-0.047354526817798615,
0.054141901433467865,
-0.36134907603263855,
-0.0594143271446228,
0.0580238401889801,
0.10821253806352615,
-0.047747284173965454,
0.02658228389918804,
-0.04339004307985306,
0.06965775042772293,
-0.019791724160313606,
0.12012702971696854,
0.13287854194641113,
-0.03202395513653755,
-0.0665784627199173,
0.1720813810825348,
0.14164946973323822,
-0.06058131530880928,
0.35137543082237244,
-0.15392976999282837,
0.10184845328330994,
-0.09959542006254196,
-0.04832567647099495,
-0.09264899045228958,
-0.17442861199378967,
-0.09201888740062714,
0.06013649329543114,
-0.17468418180942535,
0.0965455025434494,
-0.09892864525318146,
-0.20699723064899445,
-0.11369958519935608,
0.08760335296392441,
-0.12858261168003082,
-0.00036759392241947353,
0.027598783373832703,
0.05440504476428032,
-0.13200721144676208,
-0.09066446125507355,
0.04274281486868858,
0.08192520588636398,
-0.011881761252880096,
-0.07998775690793991,
-0.03958415612578392,
0.2203473448753357,
-0.08493927121162415,
0.08065915107727051,
-0.039001498371362686,
-0.10184791684150696,
0.021072043105959892,
-0.0662325918674469,
0.024266215041279793,
0.06564361602067947,
0.025326088070869446,
-0.04362289607524872,
-0.15351209044456482,
-0.15306417644023895,
-0.050378672778606415,
-0.17892338335514069,
0.133244127035141,
0.05824034661054611,
-0.3781648576259613,
-0.21112747490406036,
0.04105716943740845,
0.03347229212522507,
0.13962574303150177,
0.06455833464860916,
0.15138572454452515,
0.12117547541856766,
0.198089137673378,
0.017527608200907707,
-0.19480067491531372,
-0.05112369731068611,
-0.024301597848534584,
0.06841948628425598,
-0.2661173343658447,
-0.08806383609771729,
-0.024229414761066437,
0.21823595464229584,
-0.03940825164318085,
-0.006274729035794735,
-0.18377403914928436,
0.08163753896951675,
0.17096927762031555,
0.00446897279471159,
0.18559908866882324,
0.18621158599853516,
-0.008114185184240341,
-0.057152941823005676,
-0.12342723459005356,
0.2556529939174652,
0.16170206665992737,
0.05272752046585083,
-0.19935746490955353,
0.04501955583691597,
0.06227031722664833,
-0.06302160769701004,
0.008250068873167038,
0.23333437740802765,
0.10141371935606003,
0.02472785860300064,
0.07159245759248734,
0.24527999758720398,
-0.07149117439985275,
-0.037983398884534836,
0.06445357203483582,
-0.05669163912534714,
0.0975772812962532,
0.28375592827796936,
0.019190259277820587,
-0.11441473662853241,
-0.009231613017618656,
0.12910833954811096,
0.13148775696754456,
-0.10427301377058029,
0.0678742304444313,
0.01030292920768261,
-0.15573345124721527,
-0.0042633917182683945,
0.05476899817585945,
0.18008898198604584,
-0.14154161512851715,
0.12389747053384781,
0.0789388045668602,
-0.009430895559489727,
0.1670154631137848,
0.08062340319156647,
-0.1922997385263443,
0.04583301767706871,
0.04659699276089668,
-0.011053234338760376,
0.04076220467686653,
0.05286829173564911,
-0.1058252826333046,
0.16461654007434845,
0.06939896941184998,
0.07059839367866516,
0.04732605069875717,
0.0402953140437603,
-0.20847570896148682,
0.09486118704080582,
0.14878323674201965,
0.009930286556482315,
0.05424109473824501,
-0.08405826985836029,
-0.13547679781913757,
-0.0016673831269145012,
0.00719927903264761,
-0.0672433003783226,
-0.19423028826713562,
0.16351255774497986,
0.0266921017318964,
0.1588255763053894,
-0.08186761289834976,
0.11215747892856598,
-0.14951470494270325,
-0.027571624144911766,
-0.09292314946651459,
-0.11617965996265411,
-0.01166011393070221,
-0.23122724890708923,
0.2621171772480011,
-0.03994763642549515,
0.10803582519292831,
0.12122910469770432,
-0.04743606969714165,
0.24429874122142792,
-0.007835200987756252,
-0.00044980255188420415,
-0.19205154478549957,
-0.03388798609375954,
-0.08055887371301651,
-0.1542571783065796,
-0.037151116877794266,
0.11467187851667404,
0.20543979108333588,
0.04788394644856453,
0.32555121183395386,
0.15688090026378632,
0.06094993278384209,
-0.09207373112440109,
0.06820986419916153,
0.19757619500160217,
-0.19504830241203308,
0.08981822431087494,
-0.1584690809249878,
-0.17530596256256104,
0.19885556399822235,
0.077998585999012,
0.09448511898517609,
-0.21587741374969482,
0.0025713308714330196,
-0.13023853302001953,
-0.10272853821516037,
0.0731377974152565,
0.1258682757616043,
-0.022968625649809837,
0.0010190311586484313,
0.08422214537858963,
-0.043867792934179306,
0.11778967827558517,
0.04581321403384209,
-0.004158540163189173,
0.06322284787893295,
-0.2803501486778259,
-0.22413907945156097,
-0.1271756887435913,
0.026108821853995323,
-0.12863633036613464,
0.09565930813550949,
0.24226655066013336,
-0.11631768196821213,
0.05337466299533844,
-0.041234053671360016,
0.04019085690379143,
-0.059541307389736176,
0.39364102482795715,
-0.10012791305780411,
-0.15740616619586945,
-0.15919463336467743,
-0.0579812116920948,
-0.14497117698192596,
-0.15355612337589264,
0.0368586927652359,
0.14567819237709045,
-0.05136554688215256,
-0.13866257667541504,
0.16529925167560577,
0.16434860229492188,
0.025881631299853325,
-0.18475139141082764,
-0.27103567123413086,
0.0011886651627719402,
-0.008240059949457645,
0.11436527967453003,
-0.01665668375790119,
0.2083183228969574,
0.06441842764616013,
-0.08158926665782928,
-0.0035801490303128958,
0.023859919980168343,
0.004734982270747423,
0.2098652422428131,
0.0832696259021759,
0.07099975645542145,
0.09643204510211945,
-0.09886320680379868,
0.14098167419433594,
0.15056753158569336,
0.17344771325588226,
0.07286762446165085,
-0.04315811023116112,
-0.010340755805373192,
0.10832377523183823,
0.09526648372411728,
0.17336635291576385,
0.11081371456384659,
-0.019064437597990036,
-0.05164327099919319,
0.11453893780708313,
-0.10796515643596649,
0.04756108298897743,
0.17247991263866425,
-0.028729049488902092,
-0.1001875251531601,
-0.08966223895549774,
0.0669475644826889,
-0.16725601255893707,
-0.045293789356946945,
0.27788156270980835,
-0.09487061947584152,
0.16456876695156097,
0.04450397193431854,
-0.10245785862207413,
0.13364402949810028,
0.11251002550125122,
-0.08037295937538147,
0.028930023312568665,
0.01300694327801466,
0.0705905482172966,
-0.04609424248337746,
-0.012210244312882423,
-0.023123541846871376,
-0.06924106180667877,
0.13244813680648804,
-0.13607516884803772,
0.07116727530956268,
0.21354040503501892,
0.13219641149044037,
0.02218475192785263,
-0.1229419857263565,
0.13435694575309753,
0.12926368415355682,
0.06308561563491821,
-0.10659690946340561,
0.3737614154815674,
-0.13734975457191467,
0.055168889462947845,
0.08576378971338272,
0.24357636272907257,
0.3905479311943054,
-0.020073026418685913,
-0.09241335839033127,
0.24581700563430786,
-0.06730462610721588,
-0.019190194085240364,
-0.0534200556576252,
-0.02637030929327011,
0.08073979616165161,
0.050530217587947845,
0.05680621787905693,
-0.08625175058841705,
0.05178980156779289,
0.07879769057035446,
-0.21841366589069366,
-0.04301995038986206,
0.1372763216495514,
-0.07616043835878372,
-0.17326585948467255,
0.17443138360977173,
-0.22133082151412964,
0.12695753574371338,
-0.04885241016745567,
-0.09245730936527252,
0.009080834686756134,
0.1198490709066391,
0.013303078711032867,
0.08594896644353867,
-0.1787734180688858,
0.09244007617235184,
0.05456404387950897,
-0.1250058114528656,
-0.22954082489013672,
-0.24700631201267242,
0.10018133372068405,
-0.22911648452281952,
0.0024372520856559277,
-0.1964016556739807,
-0.07773298025131226,
-0.010679211467504501,
0.1374007612466812,
-0.0327153243124485,
0.10158425569534302,
0.19074445962905884,
0.06307701766490936,
-0.2192872315645218,
0.01954982802271843,
-0.14735224843025208,
0.06686534732580185,
-0.019882315769791603,
-0.055936142802238464,
-0.10731396824121475,
-0.0012619405752047896,
0.09880594909191132,
0.0855211690068245,
0.2514404356479645,
0.15023158490657806,
0.04600246250629425,
-0.07683625817298889,
-0.032348036766052246,
-0.1107814759016037,
-0.009665517136454582,
0.0521303229033947,
0.07040508091449738,
0.04758744314312935,
-0.08560748398303986,
0.27916401624679565,
0.08637314289808273,
0.05462382733821869,
-0.02056499570608139,
-0.09787576645612717,
0.009261862374842167,
0.2773098051548004,
0.1580178290605545,
-0.06721507757902145,
-0.08304937928915024,
-0.13164536654949188,
-0.14782431721687317,
-0.15961264073848724,
0.24161048233509064,
-0.13157890737056732,
-0.03496503084897995,
-0.004513964522629976,
-0.15725919604301453,
-0.13382241129875183,
-0.17710758745670319,
0.17386482656002045,
0.1315789520740509,
-0.24795831739902496,
0.001623652409762144,
-0.10711763054132462,
0.020900707691907883,
0.06514574587345123,
-0.0217184629291296,
0.027019307017326355,
0.3766908645629883,
-0.018565164878964424,
-0.05548197776079178,
-0.016060391440987587,
0.18855299055576324,
0.06760075688362122,
0.048212338238954544,
0.045115500688552856,
0.20344915986061096,
-0.11627991497516632,
-0.016174104064702988,
0.061515770852565765,
0.06524327397346497,
0.12990008294582367,
-0.10746439546346664,
-0.16139890253543854,
-0.046260587871074677,
0.04639921709895134,
0.15915212035179138,
-0.27132707834243774,
0.2289370894432068,
0.05482859164476395,
-0.19896048307418823,
-0.040829963982105255,
0.059138450771570206,
-0.10554257035255432,
0.2435309886932373,
-0.2979575991630554,
0.11361709982156754,
0.08932346105575562,
0.2535993456840515,
0.028525374829769135,
0.31811925768852234,
0.007368856109678745,
0.21736758947372437,
-0.2415669858455658,
-0.04053713008761406,
0.2614915668964386,
-0.1009603962302208,
-0.09365342557430267,
0.15284861624240875,
0.017493993043899536,
-0.1988534778356552,
-0.12280713766813278,
-0.04402950033545494,
0.2557418942451477,
0.031651731580495834,
0.17185495793819427,
-0.07616626471281052,
-0.20257848501205444,
-0.07871139049530029,
-0.04938589408993721,
-0.03389327973127365,
-0.004747952800244093,
-0.0030017485842108727,
-0.039178892970085144,
-0.22524107992649078,
0.14694781601428986,
0.03589808568358421,
-0.06016483157873154,
-0.10218031704425812,
-0.18860368430614471,
-0.056850358843803406,
0.1094360277056694,
-0.01265981886535883,
0.09409293532371521,
0.07918950915336609,
-0.11238662153482437,
0.09853895008563995,
0.03873034939169884,
-0.08333743363618851,
0.07101958990097046,
-0.1271311193704605,
0.05901429429650307,
-0.09993264824151993,
-0.025064541026949883,
0.1062304750084877,
0.11289447546005249,
0.12373832613229752,
0.2133694440126419,
-0.19082684814929962,
-0.1395191252231598,
-0.12552106380462646,
0.14762116968631744,
0.15139751136302948,
0.08668240159749985,
0.20510520040988922,
-0.03661368042230606,
0.06469802558422089,
-0.058077260851860046,
0.04675234109163284,
0.4494403898715973,
-0.14665091037750244,
-0.19509470462799072,
-0.12155159562826157,
-0.09969460219144821,
0.18839675188064575,
-0.02375577762722969,
-0.09104923158884048,
-0.06586863845586777,
0.05048440396785736,
-0.14162611961364746,
-0.10281433165073395,
-0.04653147980570793,
-0.08027118444442749,
0.13481712341308594,
-0.05374257639050484,
-0.15550042688846588,
0.4342811107635498,
-0.08901912719011307,
-0.046997226774692535,
0.06324376910924911,
0.020077655091881752,
0.015866504982113838,
0.08908329904079437,
0.21196182072162628,
0.04833744838833809,
-0.1686975508928299,
0.23575259745121002,
-0.3124687671661377,
-0.12603674829006195,
-0.017266204580664635,
-0.03859762102365494,
-0.30494046211242676,
0.10053342580795288,
-0.028493423014879227,
-0.15427948534488678,
0.23580825328826904,
-0.18504399061203003,
0.08745942264795303,
-0.0718252956867218,
0.1573619246482849,
-0.0767352506518364,
0.04313146695494652,
0.026343608275055885,
-0.1845712959766388,
0.19730086624622345,
0.1347666084766388,
0.007161455694586039,
-0.002125225029885769,
0.021613039076328278,
0.05428534001111984,
-0.06760909408330917,
-0.17852148413658142,
-0.14754757285118103,
0.023731105029582977,
0.13778503239154816,
0.11373262107372284,
0.09594698250293732,
-0.04236516356468201,
-0.13100458681583405,
-0.25433242321014404,
0.15187713503837585,
-0.07125706225633621,
-0.13234786689281464,
-0.01855270005762577,
0.0826309397816658,
0.05687428638339043,
0.02047009952366352,
-0.15114712715148926,
-0.04788903519511223,
-0.04526545852422714,
0.129026859998703,
0.18529477715492249,
0.019798751920461655,
-0.09798886626958847,
0.026408515870571136,
-0.38272082805633545,
-0.11043444275856018,
0.00012596735905390233,
-0.006834652740508318,
0.04062099754810333,
-0.07509112358093262,
-0.06537991762161255,
-0.050949517637491226,
0.15711794793605804,
-0.1326809525489807,
0.22192765772342682,
-0.046414393931627274,
0.18783773481845856
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. in AKT1. A detailed autopsy study of an individual showed that while there was an overall correlation of variant levels with the presence of gross or histologic manifestations of overgrowth (hypertrophy or hyperplasia), this correlation was not tight nor absolute. Some tissues with overgrowth had no detectable variant, while other apparently unaffected tissues did harbor the variant. Clinicians should be cautious when assuming that a tissue or organ is unaffected by this disease.PenetranceIncomplete penetrance cannot be assessed in a mosaic genetic disorder that is not inherited.NomenclatureOther descriptors used include elephant man disease. This descriptor is derived from the fact that Mr. Joseph Carey Merrick, who held this unfortunate descriptor, is now thought to have had PS . The use of this descriptor for other than historical purposes is discouraged.PrevalencePS is very rare. The prevalence is difficult to measure, but approximately 100 individuals are known to the author . A very rough estimate is that PS affects 1: | [
-0.3098479211330414,
0.14573869109153748,
0.22139579057693481,
-0.13633327186107635,
0.1570488065481186,
0.01411521714180708,
-0.027855731546878815,
-0.25490355491638184,
-0.004436866845935583,
-0.06769420206546783,
0.24452580511569977,
0.13098952174186707,
-0.016316359862685204,
-0.012479571625590324,
0.06601322442293167,
0.2724406123161316,
-0.1371653825044632,
0.16482959687709808,
-0.004227343946695328,
-0.05239363759756088,
-0.0629223883152008,
0.023558776825666428,
-0.09110356122255325,
0.03052038699388504,
0.012756082229316235,
-0.3019710183143616,
0.19133976101875305,
0.09777272492647171,
-0.05105266720056534,
-0.05806565657258034,
0.034978050738573074,
0.0022403590846806765,
-0.05637248232960701,
-0.1983366161584854,
-0.10683733224868774,
-0.01975247822701931,
-0.09866293519735336,
-0.004256431944668293,
0.2963758707046509,
-0.16010093688964844,
-0.15742799639701843,
0.1470969170331955,
0.03473490849137306,
-0.01877252757549286,
0.29808440804481506,
-0.13108082115650177,
-0.024957064539194107,
0.1396108716726303,
0.18474823236465454,
0.19297745823860168,
0.21985337138175964,
-0.007230403833091259,
-0.01911899633705616,
0.04857069253921509,
0.21008530259132385,
-0.08997760713100433,
0.10738186538219452,
0.1150166243314743,
-0.1654377579689026,
-0.010502993129193783,
0.07597813755273819,
0.007121593691408634,
0.13069111108779907,
-0.34321093559265137,
0.13712041079998016,
0.007159101311117411,
-0.15721337497234344,
0.3582531809806824,
0.27203112840652466,
-0.12137144058942795,
0.17802487313747406,
0.07325918972492218,
-0.16258619725704193,
-0.08359716087579727,
-0.0024712225422263145,
-0.027259360998868942,
0.07634551078081131,
-0.15545552968978882,
-0.09581786394119263,
-0.20565034449100494,
0.061346929520368576,
-0.08775218576192856,
0.048884451389312744,
0.030584754422307014,
0.030209628865122795,
-0.06579910963773727,
0.17038081586360931,
0.10924376547336578,
0.0420481339097023,
0.044058892875909805,
-0.05347662419080734,
-0.04521197825670242,
0.11199574172496796,
-0.04490409791469574,
0.29973483085632324,
-0.12499021738767624,
0.014650481753051281,
0.1540241539478302,
-0.07334697991609573,
-0.05399857833981514,
0.21022504568099976,
0.1993451863527298,
-0.13523608446121216,
0.13114988803863525,
0.272149920463562,
-0.009341339580714703,
0.02514401264488697,
0.027352768927812576,
0.1432449370622635,
0.1317370980978012,
-0.01101198885589838,
-0.230867400765419,
-0.032068051397800446,
-0.07847669720649719,
-0.2502593994140625,
-0.26445987820625305,
0.03547361120581627,
0.1077224463224411,
-0.214389830827713,
-0.24656319618225098,
0.008442545309662819,
0.02094278298318386,
-0.006826982833445072,
-0.08404019474983215,
-0.06660737097263336,
-0.12610970437526703,
0.24733135104179382,
-0.14820751547813416,
-0.07249626517295837,
-0.048658646643161774,
0.012728403322398663,
0.05548207089304924,
-0.03667190298438072,
-0.0485197976231575,
0.14369328320026398,
0.08794640004634857,
-0.15026156604290009,
0.01169049646705389,
-0.09971213340759277,
-0.048589836806058884,
0.15548741817474365,
0.0995531976222992,
0.31331583857536316,
-0.006434331182390451,
0.18456117808818817,
0.17555676400661469,
0.13349388539791107,
0.06801255792379379,
0.1226268783211708,
0.03495866805315018,
0.05413998290896416,
0.04072047397494316,
0.26870831847190857,
0.19144460558891296,
-0.05522675812244415,
-0.2886609733104706,
0.06485383957624435,
0.07034805417060852,
-0.1863907277584076,
-0.026011690497398376,
-0.15759234130382538,
-0.06115074083209038,
-0.008049288764595985,
-0.16781626641750336,
0.13839994370937347,
-0.010367478244006634,
0.06722639501094818,
-0.06765598803758621,
0.04168460890650749,
-0.0509176142513752,
-0.03806566447019577,
-0.026227183640003204,
0.06782562285661697,
0.21706122159957886,
-0.15313121676445007,
0.054902300238609314,
0.06844031065702438,
0.07833033800125122,
-0.11454369127750397,
-0.06989069283008575,
0.21234889328479767,
-0.04011611267924309,
-0.04901563376188278,
-0.2483423948287964,
-0.04373357817530632,
0.17029446363449097,
0.25185540318489075,
0.11062760651111603,
-0.09165680408477783,
0.1129869818687439,
0.1768343597650528,
0.0866508036851883,
-0.267829954624176,
0.054078299552202225,
0.044403042644262314,
-0.28601324558258057,
0.04210297390818596,
0.09116192162036896,
-0.10312674194574356,
-0.013413487002253532,
0.08381254225969315,
-0.15371690690517426,
0.024499140679836273,
0.07210629433393478,
0.10719431191682816,
0.1318443864583969,
0.047561127692461014,
0.05029057338833809,
-0.013285101391375065,
0.07919799536466599,
0.004811845254153013,
0.22094246745109558,
-0.2390766143798828,
0.048204801976680756,
-0.10401485860347748,
-0.18279719352722168,
0.02738485485315323,
-0.1545504331588745,
0.06203262135386467,
0.02310541644692421,
-0.24152871966362,
0.004003890790045261,
-0.14627334475517273,
-0.29558229446411133,
0.08163265138864517,
0.05521633103489876,
-0.09781185537576675,
-0.005441311746835709,
-0.018596166744828224,
0.05888163670897484,
0.02663997747004032,
0.004752310924232006,
0.030087867751717567,
0.045716095715761185,
-0.000631895789410919,
-0.36024823784828186,
0.007533765863627195,
0.021922802552580833,
-0.07660357654094696,
0.16741742193698883,
-0.07313912361860275,
-0.016769610345363617,
0.09608563035726547,
-0.12672413885593414,
0.148153156042099,
0.14509150385856628,
0.04525182768702507,
-0.006341380998492241,
-0.023336414247751236,
-0.004065088462084532,
0.0665452852845192,
-0.09721893072128296,
0.23502478003501892,
0.04993829503655434,
-0.2225789874792099,
-0.04270297661423683,
0.22281815111637115,
0.059069033712148666,
0.2128315418958664,
0.061941105872392654,
0.034489914774894714,
0.1617184728384018,
0.11239384114742279,
-0.04692329466342926,
-0.2272450029850006,
-0.0980871245265007,
0.11726859211921692,
0.14268314838409424,
-0.26264962553977966,
-0.14565029740333557,
-0.07148314267396927,
0.1336131989955902,
0.026423702016472816,
0.0026025574188679457,
0.04834361374378204,
-0.02336292155086994,
-0.10048055648803711,
0.014229364693164825,
0.21286869049072266,
0.06810986250638962,
0.19870370626449585,
-0.18659837543964386,
-0.05139271914958954,
0.09069047123193741,
0.24818505346775055,
0.06335847824811935,
-0.2861224114894867,
0.1860886961221695,
0.10582047700881958,
-0.008020143024623394,
0.13949432969093323,
0.14685384929180145,
-0.12954020500183105,
-0.16276244819164276,
0.1085052639245987,
0.24401986598968506,
-0.1674850583076477,
0.30927571654319763,
0.059209343045949936,
-0.1451178342103958,
0.25892630219459534,
0.12756523489952087,
0.015997955575585365,
0.008132046088576317,
-0.04729834198951721,
-0.12472885847091675,
0.14936237037181854,
-0.20247972011566162,
-0.040522221475839615,
-0.10504255443811417,
-0.059781547635793686,
0.09198245406150818,
0.059821803122758865,
0.22639377415180206,
0.061400432139635086,
-0.011730617843568325,
-0.12522755563259125,
-0.03588680177927017,
0.2090274691581726,
-0.040223728865385056,
0.11200767755508423,
-0.018862711265683174,
0.11008913815021515,
0.008565420284867287,
-0.06035005301237106,
0.14341916143894196,
-0.11896514892578125,
0.03416018560528755,
-0.05705229192972183,
0.10539560765028,
0.06396558880805969,
0.012060114182531834,
-0.1738957017660141,
-0.08773061633110046,
0.10504966974258423,
-0.004752220120280981,
0.0871991291642189,
-0.1437264233827591,
-0.10327517986297607,
0.12206248939037323,
-0.14429692924022675,
-0.09787013381719589,
0.07046058773994446,
-0.03321699798107147,
-0.1085241362452507,
0.1326046735048294,
-0.11269227415323257,
-0.09523992985486984,
-0.0016298097325488925,
-0.13498879969120026,
-0.110048308968544,
-0.2789585590362549,
0.05405780300498009,
-0.08532065153121948,
0.22283071279525757,
0.08792362362146378,
0.15607663989067078,
0.1821099817752838,
-0.13396607339382172,
-0.0004454682348296046,
-0.00458165630698204,
-0.11483216285705566,
-0.06131784990429878,
-0.0627908706665039,
-0.17917312681674957,
-0.061892200261354446,
-0.08441083133220673,
0.09385795891284943,
0.11257284134626389,
-0.008314309641718864,
0.3058183193206787,
0.14893832802772522,
-0.008061549626290798,
-0.07811710983514786,
0.09907017648220062,
-0.0035927677527070045,
-0.04012315347790718,
0.0313790887594223,
-0.25328320264816284,
-0.1918938308954239,
-0.006768662948161364,
-0.01967986300587654,
0.03865763172507286,
-0.23277175426483154,
-0.12991741299629211,
0.12736906111240387,
-0.14832803606987,
0.050649818032979965,
0.03564377501606941,
-0.030580518767237663,
0.2244034707546234,
0.033156223595142365,
-0.09420828521251678,
0.22626592218875885,
0.04319620877504349,
-0.0065336450934410095,
0.14569595456123352,
-0.11473730206489563,
-0.1310160756111145,
-0.04218506067991257,
0.022022968158125877,
-0.022583043202757835,
-0.02294308878481388,
0.010462197475135326,
0.23365095257759094,
0.055043719708919525,
-0.19066111743450165,
0.06806237250566483,
-0.09784302115440369,
0.3102189302444458,
0.06591332703828812,
0.018611092120409012,
-0.07577338814735413,
-0.22913670539855957,
0.003224265528842807,
-0.12058572471141815,
-0.05499689280986786,
-0.10763347893953323,
0.20169195532798767,
-0.14113913476467133,
0.0018215228337794542,
-0.12820619344711304,
0.1488228589296341,
0.012130774557590485,
-0.020479772239923477,
-0.04923545941710472,
0.1620234102010727,
-0.026381608098745346,
-0.08044848591089249,
0.09032320231199265,
0.10444924980401993,
-0.08062520623207092,
-0.16065473854541779,
0.008672072552144527,
0.0141835892572999,
0.2167290598154068,
-0.08774774521589279,
-0.006656893063336611,
0.03184295445680618,
-0.0093024130910635,
0.4017122983932495,
0.08922944217920303,
-0.10011664777994156,
0.04835549369454384,
-0.021941494196653366,
0.09302081167697906,
-0.012140524573624134,
-0.03209982439875603,
-0.04014935344457626,
0.016376297920942307,
0.015337510965764523,
-0.022370200604200363,
-0.05980495363473892,
0.013838632963597775,
0.06300576776266098,
-0.04220551252365112,
-0.14108684659004211,
0.116855688393116,
-0.19779834151268005,
0.23535458743572235,
-0.22395677864551544,
0.18690620362758636,
0.1195879653096199,
-0.16056814789772034,
0.14800402522087097,
0.06129447743296623,
-0.26032501459121704,
-0.048911597579717636,
0.10559206455945969,
0.06775642931461334,
0.09770160913467407,
0.05786371976137161,
0.1672210842370987,
-0.04629446566104889,
0.05719740688800812,
0.17562970519065857,
-0.15574440360069275,
0.1575276255607605,
0.006610463839024305,
-0.0782204121351242,
0.18235182762145996,
-0.05118311569094658,
0.04573231190443039,
-0.18434081971645355,
-0.06569685786962509,
0.007825072854757309,
0.02225494012236595,
-0.1303745061159134,
0.42740967869758606,
-0.05389801412820816,
0.009199748747050762,
0.10256490111351013,
0.0815834105014801,
0.2958122491836548,
-0.04742903634905815,
-0.08071281760931015,
0.12629596889019012,
-0.06955830007791519,
0.10382368415594101,
0.1203165203332901,
-0.06525126844644547,
0.23651491105556488,
0.07361830025911331,
0.026026763021945953,
0.04978151246905327,
-0.016915319487452507,
0.059234630316495895,
-0.2516721785068512,
-0.15334834158420563,
0.021501651033759117,
-0.0038816200103610754,
0.005290334578603506,
0.0026059856172651052,
-0.15125344693660736,
0.08617208898067474,
0.03421782702207565,
-0.025545742362737656,
-0.09935165196657181,
0.032279081642627716,
-0.09805456548929214,
-0.11304505914449692,
0.06754927337169647,
0.13348902761936188,
0.07094317674636841,
-0.14046594500541687,
-0.146680548787117,
-0.2190166860818863,
0.0241192989051342,
-0.14986832439899445,
-0.21576574444770813,
-0.11710668355226517,
-0.07217123359441757,
0.1161414086818695,
0.0017620959552004933,
0.0676676332950592,
0.10982646048069,
-0.124859519302845,
-0.059980783611536026,
-0.16865955293178558,
-0.08087325096130371,
-0.16797323524951935,
0.1657274216413498,
0.052641045302152634,
0.07199129462242126,
-0.051730263978242874,
0.112254798412323,
0.12975440919399261,
-0.08608946204185486,
0.1341978758573532,
0.20786453783512115,
0.09252221882343292,
0.008464816026389599,
0.036586031317710876,
-0.2232978492975235,
-0.14618001878261566,
0.05282110348343849,
0.045832935720682144,
0.035284657031297684,
-0.0450211763381958,
0.1813378930091858,
0.09516739100217819,
0.08224064111709595,
0.09362395107746124,
-0.11008639633655548,
0.12291489541530609,
0.10253646969795227,
0.30698472261428833,
-0.05002974346280098,
-0.11886889487504959,
0.020949767902493477,
0.013509868644177914,
0.08091370761394501,
0.19015704095363617,
-0.2244456708431244,
-0.16289475560188293,
0.08846081793308258,
-0.23505692183971405,
-0.044246550649404526,
-0.10622699558734894,
0.124155692756176,
0.07887914031744003,
-0.23054563999176025,
-0.043698109686374664,
-0.15871237218379974,
0.04950563237071037,
0.2827994227409363,
0.0028485890943557024,
0.20149244368076324,
0.22994260489940643,
0.14526978135108948,
0.05690368264913559,
-0.010802030563354492,
0.026171091943979263,
0.06035343185067177,
-0.07987551391124725,
-0.09432029724121094,
0.17076708376407623,
-0.01063315849751234,
-0.06558042019605637,
0.01808062009513378,
-0.030721964314579964,
-0.021999197080731392,
-0.16161614656448364,
-0.132679745554924,
-0.048638079315423965,
-0.09968414902687073,
0.09165182709693909,
-0.28295665979385376,
0.15173430740833282,
-0.08135870099067688,
-0.03424564003944397,
-0.016093626618385315,
0.06768493354320526,
-0.10131295770406723,
0.07196497917175293,
-0.24030157923698425,
0.008514613844454288,
-0.18165823817253113,
0.23211531341075897,
-0.1044473871588707,
0.23033280670642853,
0.1280183643102646,
0.046464696526527405,
-0.22593839466571808,
0.07329854369163513,
0.45583948493003845,
-0.16464103758335114,
-0.15080444514751434,
0.16765062510967255,
0.15309229493141174,
0.02142954245209694,
0.03879023715853691,
0.007342539727687836,
0.2502950429916382,
0.04484208673238754,
0.22698619961738586,
0.03024408034980297,
-0.05733649060130119,
-0.007433080580085516,
-0.07003007084131241,
-0.10659880191087723,
-0.04864441975951195,
0.09555715322494507,
0.07092400640249252,
-0.17832842469215393,
0.11501523852348328,
-0.19210787117481232,
-0.008250529877841473,
-0.22504037618637085,
-0.1843239963054657,
0.011052839457988739,
0.09915805608034134,
0.02553706243634224,
0.07458149641752243,
0.05150581896305084,
-0.2595747113227844,
0.095960833132267,
-0.11259779334068298,
0.14604268968105316,
-0.059644296765327454,
-0.14575102925300598,
0.06369219720363617,
-0.05083060264587402,
0.015060151927173138,
-0.04000522568821907,
0.26890528202056885,
-0.11913280934095383,
0.19559215009212494,
-0.07350970059633255,
-0.2952883541584015,
-0.21662260591983795,
0.04823453351855278,
0.19012312591075897,
-0.05644587427377701,
-0.008700610138475895,
0.08329907804727554,
0.08865141123533249,
-0.1117793619632721,
-0.0016979416832327843,
0.5687850713729858,
-0.05615973100066185,
-0.31423088908195496,
-0.2689190208911896,
-0.17175385355949402,
0.060443367809057236,
-0.09048690646886826,
-0.04954877868294716,
-0.1250486969947815,
-0.056224554777145386,
0.1279217153787613,
-0.04969780519604683,
-0.03946557641029358,
-0.09370800852775574,
0.09687425196170807,
-0.12374456971883774,
-0.1607387810945511,
0.35254600644111633,
-0.006948165129870176,
-0.005101215559989214,
0.036972496658563614,
0.023980258032679558,
0.00901472382247448,
-0.10954249650239944,
0.25647979974746704,
0.0049545313231647015,
-0.12357605993747711,
0.06371869891881943,
-0.13610662519931793,
0.008896819315850735,
-0.022187918424606323,
-0.10651014745235443,
-0.1945849061012268,
-0.019830817356705666,
0.08950518071651459,
-0.02782859280705452,
0.23347271978855133,
-0.0831531211733818,
0.09694883227348328,
-0.07021229714155197,
-0.11903807520866394,
-0.07566323131322861,
-0.06846069544553757,
0.04277355223894119,
-0.0993552878499031,
0.12050410360097885,
0.021921994164586067,
-0.09653464704751968,
0.04729354381561279,
0.14163422584533691,
0.09793663024902344,
-0.021853720769286156,
-0.017315510660409927,
-0.07663420587778091,
0.1359952986240387,
-0.11996109783649445,
0.15785014629364014,
0.25386059284210205,
0.06523511558771133,
-0.08829949051141739,
-0.23819074034690857,
-0.04690727964043617,
0.014633876271545887,
-0.020733602344989777,
-0.057189591228961945,
0.18378916382789612,
-0.06601721048355103,
-0.010556445457041264,
-0.060823678970336914,
0.07313750684261322,
-0.2015155553817749,
-0.008630428463220596,
0.07669388502836227,
-0.05700981244444847,
-0.03791440650820732,
0.05417437106370926,
-0.18427127599716187,
0.0374750979244709,
-0.17083193361759186,
-0.19774386286735535,
-0.00947919487953186,
-0.08698269724845886,
0.07828564196825027,
0.006279047578573227,
0.03048533760011196,
-0.22611407935619354,
-0.04349101707339287,
0.043340589851140976,
-0.1393274962902069
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. disorder that is not inherited.NomenclatureOther descriptors used include elephant man disease. This descriptor is derived from the fact that Mr. Joseph Carey Merrick, who held this unfortunate descriptor, is now thought to have had PS . The use of this descriptor for other than historical purposes is discouraged.PrevalencePS is very rare. The prevalence is difficult to measure, but approximately 100 individuals are known to the author . A very rough estimate is that PS affects 1:1,000,000 – 1:10,000,000 persons.PS is pan ethnic.Differential DiagnosisSignificant diagnostic confusion regarding Proteus syndrome (PS) exists. Although the following disorders share some features with PS, both the natural history (i.e., almost always postnatal onset) and manifestations (e.g., disproportionate and progressive distorting skeletal overgrowth, CCTN) of PS are important distinctions that can aid in clinical diagnosis.PTEN hamartoma | [
-0.26899412274360657,
-0.03390732407569885,
0.2468317747116089,
-0.2166004776954651,
0.1233687475323677,
-0.04473758488893509,
-0.05617997422814369,
-0.2436779886484146,
-0.09928427636623383,
0.07777334004640579,
0.13029631972312927,
0.09363098442554474,
-0.07635238766670227,
-0.05266681686043739,
0.06956906616687775,
0.32454168796539307,
0.05608862265944481,
0.12833252549171448,
-0.05018645524978638,
-0.06470191478729248,
0.00008064973371801898,
0.005100636277347803,
-0.08693720400333405,
0.000624649808742106,
0.04604087024927139,
-0.22211946547031403,
0.268982857465744,
0.15843026340007782,
-0.06941475719213486,
-0.1131034791469574,
0.11299043148756027,
0.026417115703225136,
-0.06311336159706116,
-0.26484811305999756,
0.09222093969583511,
-0.044517215341329575,
-0.16632682085037231,
-0.002546600764617324,
0.09934520721435547,
-0.11030920594930649,
-0.06455428153276443,
0.12481393665075302,
0.031131859868764877,
-0.23839455842971802,
0.3200480043888092,
-0.13309086859226227,
-0.1715238243341446,
0.18981453776359558,
0.23234891891479492,
0.15681931376457214,
0.2639201283454895,
0.04073743894696236,
-0.07840605825185776,
-0.009866248816251755,
0.015475057065486908,
-0.31024685502052307,
0.04829312860965729,
0.032827071845531464,
-0.16129477322101593,
0.029212813824415207,
0.08903714269399643,
0.03530365973711014,
0.1365794688463211,
-0.44613710045814514,
0.01721556857228279,
-0.14852745831012726,
0.028939153999090195,
0.3700253367424011,
0.19646257162094116,
-0.05903257802128792,
0.4544823467731476,
0.0204998180270195,
-0.23058731853961945,
-0.03532050549983978,
-0.04901055246591568,
-0.108976811170578,
0.10012481361627579,
-0.009956691414117813,
-0.05912256985902786,
-0.12791094183921814,
0.011760746128857136,
0.07508865743875504,
-0.021834727376699448,
-0.0444326177239418,
-0.027739886194467545,
-0.11968988925218582,
0.11998935788869858,
0.19391676783561707,
-0.0029273254331201315,
0.12120665609836578,
0.04180840775370598,
-0.09891658276319504,
0.06292104721069336,
-0.06308069080114365,
0.33737123012542725,
-0.06606687605381012,
0.07839490473270416,
0.038253407925367355,
-0.2902871072292328,
-0.1181972399353981,
0.04845236614346504,
0.33895018696784973,
-0.06746428459882736,
0.12049134075641632,
0.15758948028087616,
-0.13828857243061066,
-0.004738181829452515,
0.14302200078964233,
0.025086384266614914,
-0.008690431714057922,
0.08062013238668442,
-0.17904625833034515,
0.06699889898300171,
-0.07031681388616562,
-0.2267589271068573,
-0.1095583438873291,
0.18569745123386383,
0.07496893405914307,
-0.12600424885749817,
-0.334482878446579,
-0.00019407179206609726,
-0.07867050170898438,
-0.09918201714754105,
-0.06911659240722656,
-0.014248237945139408,
-0.018927786499261856,
0.3637201488018036,
-0.2861901521682739,
-0.05997190997004509,
-0.1794404238462448,
0.008386756293475628,
-0.05401824787259102,
-0.14057238399982452,
-0.0672597736120224,
0.15668830275535583,
0.13510778546333313,
-0.2095641791820526,
-0.0898216962814331,
-0.0066907210275530815,
0.05319048836827278,
0.15513846278190613,
0.08478186279535294,
0.1925860494375229,
0.08969175815582275,
0.3040362596511841,
0.07810484617948532,
0.05450604483485222,
0.10971061140298843,
0.11242938041687012,
0.046067025512456894,
0.08842286467552185,
0.10678241401910782,
0.42250266671180725,
0.16912229359149933,
0.019496388733386993,
-0.1183105930685997,
-0.1072029322385788,
-0.10766346752643585,
-0.12836460769176483,
0.13216359913349152,
-0.12774543464183807,
-0.07569047808647156,
-0.018121521919965744,
-0.19962172210216522,
0.13088920712471008,
0.029593834653496742,
0.04193615913391113,
-0.02230067178606987,
0.109679214656353,
0.046158939599990845,
-0.07514242827892303,
-0.07427801191806793,
-0.035358719527721405,
0.10927168279886246,
-0.14210554957389832,
0.10429263114929199,
0.028488660231232643,
0.11298330128192902,
-0.09826859086751938,
0.03932204470038414,
0.13155190646648407,
-0.05677396431565285,
-0.13319142162799835,
-0.3543980121612549,
-0.09195463359355927,
-0.018763136118650436,
0.13144023716449738,
0.05879409611225128,
-0.09525845944881439,
0.0796179473400116,
0.07994566857814789,
-0.0027183317579329014,
-0.22853566706180573,
-0.13722433149814606,
0.007461157161742449,
-0.33998483419418335,
-0.01791548542678356,
-0.09147918969392776,
-0.001401696354150772,
0.11081159114837646,
0.22847603261470795,
-0.06123913824558258,
0.06980588287115097,
-0.027899067848920822,
0.1567249298095703,
0.14469574391841888,
0.18293671309947968,
-0.04723575711250305,
0.08127976208925247,
0.21763290464878082,
-0.03971696272492409,
0.34354469180107117,
-0.26567938923835754,
0.09123837947845459,
0.07806826382875443,
-0.22942349314689636,
0.06119242683053017,
-0.14829178154468536,
0.07269947230815887,
0.1723247915506363,
-0.12919223308563232,
0.10519161820411682,
-0.2899377644062042,
-0.2007133662700653,
0.017741898074746132,
0.1258152723312378,
-0.03254225105047226,
-0.04485003650188446,
-0.008401327766478062,
0.0208287350833416,
-0.1407882571220398,
0.010526470839977264,
0.08212024718523026,
0.17521712183952332,
0.11005562543869019,
-0.3709146976470947,
-0.0439135879278183,
0.13877896964550018,
-0.04350573197007179,
0.11476324498653412,
-0.18559585511684418,
-0.12114636600017548,
0.08761720359325409,
-0.07666783779859543,
-0.0001951580197783187,
0.21472826600074768,
0.06504002958536148,
0.057950619608163834,
-0.028424814343452454,
-0.05231958627700806,
0.025398142635822296,
-0.3015817403793335,
0.16494300961494446,
0.12203330546617508,
-0.331673264503479,
-0.04485353082418442,
0.26044130325317383,
0.027788672596216202,
0.2382809817790985,
0.05815095081925392,
0.0980108380317688,
0.06428629904985428,
0.1530345380306244,
-0.024838576093316078,
-0.2740156054496765,
-0.20460925996303558,
0.10546475648880005,
0.09793657064437866,
-0.17235617339611053,
-0.25261208415031433,
0.014698267914354801,
0.13472412526607513,
0.04409240186214447,
0.07528272271156311,
-0.02344166301190853,
-0.08122283220291138,
-0.07968586683273315,
0.1464410275220871,
0.1939498335123062,
0.04383542761206627,
0.1753089427947998,
-0.18192698061466217,
-0.10518117249011993,
0.06452132761478424,
0.2541583478450775,
0.07476874440908432,
-0.4164281487464905,
0.21248367428779602,
0.007134805433452129,
0.04514022916555405,
0.13342970609664917,
0.14807076752185822,
0.04630091413855553,
-0.1473594456911087,
0.01772114261984825,
0.2973073422908783,
-0.14841416478157043,
0.027784422039985657,
0.09872111678123474,
-0.23386763036251068,
0.2883162498474121,
0.14979417622089386,
0.010262162424623966,
0.1622726321220398,
-0.0030173894483596087,
-0.14049673080444336,
0.23472483456134796,
-0.1736077219247818,
-0.036323368549346924,
-0.1269713044166565,
-0.1832519918680191,
0.14608317613601685,
0.14128822088241577,
0.283569872379303,
0.08540499955415726,
-0.08630747348070145,
-0.20668520033359528,
0.022758811712265015,
0.1975487768650055,
0.08141223341226578,
0.14266124367713928,
-0.14882712066173553,
0.18709725141525269,
0.07155068218708038,
0.13731661438941956,
0.2657015323638916,
-0.16870208084583282,
0.10701315850019455,
-0.06460502743721008,
0.11208927631378174,
0.07154859602451324,
-0.01575138419866562,
-0.25435301661491394,
-0.13709799945354462,
-0.03931715339422226,
0.0641840472817421,
-0.060692302882671356,
-0.1397504061460495,
-0.08143587410449982,
0.05306435003876686,
-0.08249204605817795,
-0.10698918253183365,
0.027452964335680008,
-0.05565774440765381,
-0.1456352174282074,
0.1525593250989914,
-0.09286557137966156,
0.1166531890630722,
-0.07664112001657486,
-0.25784409046173096,
-0.0875893086194992,
-0.3456581234931946,
-0.045978982001543045,
-0.2973960041999817,
0.06816091388463974,
0.07109387218952179,
0.05976327136158943,
0.09448039531707764,
-0.03571547940373421,
-0.004766139667481184,
-0.022271711379289627,
-0.06269394606351852,
-0.1001582220196724,
-0.04189864173531532,
-0.1749449223279953,
0.007293438073247671,
-0.1682559996843338,
0.18116848170757294,
0.11892524361610413,
0.02082262746989727,
0.33882129192352295,
0.06204686313867569,
0.010121646337211132,
-0.10694903880357742,
0.0948920026421547,
0.1186123639345169,
-0.08436460047960281,
0.12819376587867737,
-0.20883135497570038,
-0.16574537754058838,
-0.013979624025523663,
0.01909734308719635,
0.0857669934630394,
-0.23542377352714539,
-0.17182227969169617,
0.1117766872048378,
-0.2376379817724228,
0.1482098549604416,
-0.02671988122165203,
0.10546144843101501,
0.25499752163887024,
-0.07265791296958923,
-0.19120445847511292,
0.1589137762784958,
0.03181125223636627,
-0.14234764873981476,
0.15972845256328583,
-0.1474510133266449,
-0.08235523104667664,
0.010898827575147152,
0.006124761886894703,
0.010604475624859333,
-0.05175095796585083,
0.08936509490013123,
0.34675082564353943,
-0.006049186922609806,
-0.20013651251792908,
0.020091580227017403,
-0.20134226977825165,
0.3411409854888916,
-0.0780705139040947,
-0.07708895951509476,
-0.13685506582260132,
-0.3274364471435547,
-0.04117267578840256,
-0.102631576359272,
0.11160143464803696,
-0.09417843073606491,
0.18373866379261017,
-0.02512320876121521,
0.1473241150379181,
-0.16956311464309692,
0.11754348129034042,
-0.0415416844189167,
0.024600591510534286,
-0.004427944775670767,
-0.10017300397157669,
-0.08538437634706497,
-0.13384242355823517,
0.13428498804569244,
0.05462218448519707,
-0.08888718485832214,
-0.17587900161743164,
0.06557168066501617,
0.038588594645261765,
0.15905530750751495,
-0.045181676745414734,
-0.12020059674978256,
-0.08204745501279831,
-0.10921204835176468,
0.33822759985923767,
0.10364297032356262,
-0.09717419743537903,
0.05820072069764137,
0.10124960541725159,
0.08579010516405106,
-0.05843557044863701,
-0.007733005564659834,
-0.09109718352556229,
-0.0467824786901474,
0.004378252197057009,
-0.05809622257947922,
0.013723980635404587,
-0.020764313638210297,
0.14433760941028595,
-0.013452446088194847,
-0.15119919180870056,
0.03998217731714249,
-0.26530271768569946,
0.06476381421089172,
-0.17458640038967133,
0.07562227547168732,
0.2458011358976364,
-0.18394170701503754,
0.047031935304403305,
0.181858092546463,
-0.3429759442806244,
-0.04879002273082733,
0.18035511672496796,
0.09302432090044022,
0.08949743211269379,
0.09057558327913284,
0.14454293251037598,
-0.029871227219700813,
-0.1258610635995865,
0.14501681923866272,
-0.04268672317266464,
0.11061713844537735,
-0.040963973850011826,
0.0857752189040184,
0.13532549142837524,
0.0742848664522171,
-0.009406212717294693,
-0.06869220733642578,
-0.012511923909187317,
0.08780320733785629,
0.023415662348270416,
-0.1925876885652542,
0.472368985414505,
-0.149219810962677,
0.2537040710449219,
-0.10875403881072998,
0.06391624361276627,
0.22838324308395386,
-0.006753850262612104,
0.019257724285125732,
0.1349029839038849,
-0.08092331141233444,
0.09310466796159744,
0.009760578162968159,
-0.14966051280498505,
0.1965108960866928,
0.06364706158638,
0.023886973038315773,
0.15770195424556732,
-0.07512378692626953,
-0.00186672224663198,
-0.35012537240982056,
-0.1866661012172699,
0.1033199280500412,
-0.11827041953802109,
0.028459228575229645,
-0.19889022409915924,
-0.18891699612140656,
0.08178755640983582,
-0.0018790343310683966,
0.020809080451726913,
-0.1079636961221695,
-0.0008447227883152664,
-0.004428948741406202,
-0.1350344568490982,
0.11189105361700058,
0.03113175556063652,
-0.028918391093611717,
-0.19537422060966492,
-0.12720397114753723,
-0.1651940792798996,
0.2152254581451416,
-0.22265371680259705,
-0.11868565529584885,
-0.07032383233308792,
-0.16833850741386414,
0.1567993015050888,
-0.02308047004044056,
0.13080501556396484,
0.026555564254522324,
0.004115559626370668,
-0.1442069113254547,
-0.07116382569074631,
0.1475020945072174,
-0.16073185205459595,
0.2932884693145752,
-0.06986739486455917,
0.03623272106051445,
0.024404989555478096,
-0.005280355457216501,
0.1578272432088852,
-0.10245588421821594,
0.1100790873169899,
0.3585723042488098,
0.10953300446271896,
-0.0819343626499176,
0.03580794110894203,
-0.21864807605743408,
-0.21639175713062286,
0.0060684517957270145,
-0.0061431750655174255,
-0.12267055362462997,
-0.07349503040313721,
0.06277432292699814,
0.030002295970916748,
0.2884056568145752,
-0.05037049204111099,
-0.1367809772491455,
0.037652965635061264,
0.17413243651390076,
0.29578709602355957,
-0.04908587411046028,
-0.0599183514714241,
-0.003208822337910533,
-0.012717696838080883,
0.024237794801592827,
0.30459094047546387,
-0.20920830965042114,
-0.14413601160049438,
-0.13148176670074463,
-0.2392149418592453,
-0.2180320769548416,
-0.18561674654483795,
0.16966187953948975,
0.13216862082481384,
-0.20809654891490936,
-0.004201913718134165,
-0.2528477907180786,
0.18931818008422852,
0.3989053964614868,
-0.005813388153910637,
0.1857306957244873,
0.29946044087409973,
0.16481180489063263,
0.05942930281162262,
-0.06239467114210129,
0.08892329782247543,
0.11223325878381729,
-0.06970809400081635,
-0.1260862499475479,
0.19989442825317383,
0.09711377322673798,
0.06462588161230087,
-0.077426977455616,
0.11491404473781586,
0.04443987086415291,
-0.21949787437915802,
-0.05699799582362175,
-0.026672905310988426,
-0.11728081107139587,
0.14427629113197327,
-0.18556994199752808,
0.2838360667228699,
-0.09731552004814148,
-0.05152004957199097,
-0.09029129147529602,
-0.09627208858728409,
0.05126352608203888,
0.10407191514968872,
-0.18502721190452576,
0.11947793513536453,
-0.10973481833934784,
0.3398507535457611,
-0.13474538922309875,
0.38708826899528503,
0.13841992616653442,
0.20218363404273987,
-0.20070070028305054,
-0.05233851075172424,
0.48440805077552795,
-0.20819878578186035,
-0.1017681285738945,
0.1566491723060608,
-0.05028820410370827,
0.07344158738851547,
0.0766182541847229,
-0.031309109181165695,
0.1711152046918869,
-0.06315786391496658,
0.16544173657894135,
0.08250356465578079,
-0.019735468551516533,
0.004152704030275345,
-0.07050264626741409,
-0.11222460120916367,
0.16751667857170105,
-0.007907222956418991,
0.19448935985565186,
-0.2932971715927124,
0.23101598024368286,
-0.19116397202014923,
0.0021764258854091167,
-0.277679979801178,
-0.2828519642353058,
-0.041947029531002045,
0.08654184639453888,
-0.020102903246879578,
0.14878518879413605,
0.17465448379516602,
-0.14781442284584045,
0.005250530783087015,
-0.054265208542346954,
0.24200735986232758,
-0.06915710121393204,
-0.17545296251773834,
-0.016817105934023857,
-0.003185341600328684,
0.019465317949652672,
-0.10777737945318222,
0.1992657482624054,
-0.1018323302268982,
0.029909007251262665,
-0.28331953287124634,
-0.44642385840415955,
-0.3792855441570282,
0.062271516770124435,
0.19150768220424652,
-0.09855681657791138,
0.0627816915512085,
0.05084500089287758,
0.17679080367088318,
-0.2976456582546234,
0.05506955832242966,
0.5844294428825378,
-0.10140898823738098,
-0.44986554980278015,
-0.28167060017585754,
-0.03491644933819771,
0.029289329424500465,
0.023272283375263214,
-0.030909579247236252,
-0.05842611566185951,
-0.09325341880321503,
0.0007954866741783917,
-0.01106699462980032,
-0.0224771611392498,
-0.08504153043031693,
0.1227889433503151,
-0.09257066249847412,
-0.2921255826950073,
0.5674363374710083,
-0.03405141085386276,
-0.011574766598641872,
0.05702678859233856,
-0.040209975093603134,
-0.050323087722063065,
-0.12008141726255417,
0.1470845639705658,
0.04538353160023689,
-0.2344048023223877,
0.03134053945541382,
-0.15208826959133148,
0.15448778867721558,
-0.09417396038770676,
0.02739216387271881,
-0.02697983756661415,
-0.0940304845571518,
0.25385111570358276,
0.09976013749837875,
0.3457120656967163,
-0.2373698651790619,
0.08570696413516998,
-0.12014982104301453,
-0.12052363157272339,
-0.12895677983760834,
-0.04770839586853981,
-0.0127129340544343,
-0.12183194607496262,
0.14575430750846863,
0.014693818986415863,
0.03425873443484306,
0.003487708978354931,
0.15715332329273224,
0.10398250818252563,
0.021787868812680244,
0.00024110909726005048,
-0.017061885446310043,
0.13753271102905273,
-0.014056560583412647,
0.14156731963157654,
0.34907376766204834,
0.14273783564567566,
-0.14194679260253906,
-0.2132565975189209,
-0.09246581792831421,
0.10129878669977188,
0.028129732236266136,
-0.1497945934534073,
0.13847288489341736,
-0.18148140609264374,
0.08008048683404922,
-0.02054957114160061,
0.16478149592876434,
-0.14319217205047607,
-0.10908188670873642,
0.05905962735414505,
0.1701168268918991,
0.02861468493938446,
-0.04993503913283348,
-0.21393811702728271,
-0.002479417948052287,
-0.1245289072394371,
-0.18386754393577576,
0.04204200953245163,
-0.1620662361383438,
-0.0868038460612297,
-0.02843160554766655,
0.005395411513745785,
-0.18917971849441528,
0.04891406372189522,
0.05769006907939911,
-0.15007811784744263
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. that PS affects 1:1,000,000 – 1:10,000,000 persons.PS is pan ethnic.Differential DiagnosisSignificant diagnostic confusion regarding Proteus syndrome (PS) exists. Although the following disorders share some features with PS, both the natural history (i.e., almost always postnatal onset) and manifestations (e.g., disproportionate and progressive distorting skeletal overgrowth, CCTN) of PS are important distinctions that can aid in clinical diagnosis.PTEN hamartoma tumor syndrome
(PHTS) is a heterogeneous disorder that manifests asymmetric overgrowth, macrocephaly, cutaneous vascular malformations, and tumor susceptibility. The full spectrum of this interesting and distinctive disorder is not known, but it can be readily distinguished from PS. A phenotypic subtype, described as type II segmental Cowden syndrome or SOLAMEN syndrome , is the consequence of a germline pathogenic variant in PTEN with a somatic, mosaic second PTEN variant that gives the phenotype its segmental attributes.PTHS includes | [
-0.20005562901496887,
-0.07098150998353958,
0.07247794419527054,
-0.21671618521213531,
0.10908225178718567,
-0.026709958910942078,
-0.07188065350055695,
-0.2107536941766739,
-0.12996283173561096,
0.10294514894485474,
0.16999225318431854,
0.02078087627887726,
-0.09241680800914764,
0.08047779649496078,
-0.12607286870479584,
0.3350329101085663,
-0.0875864028930664,
-0.013874064199626446,
-0.07811789959669113,
0.10579182207584381,
0.06521711498498917,
-0.054650112986564636,
0.02750076726078987,
0.07379917055368423,
0.058611318469047546,
-0.317589670419693,
0.17546841502189636,
0.17961038649082184,
-0.03153039887547493,
-0.02242191694676876,
0.1170605942606926,
-0.051520127803087234,
-0.11673816293478012,
-0.27951863408088684,
0.05625610426068306,
-0.20004218816757202,
-0.1569528579711914,
-0.020739473402500153,
0.13185067474842072,
-0.09140842407941818,
0.004485681187361479,
0.14866292476654053,
-0.05539132282137871,
-0.19508096575737,
0.2713695466518402,
-0.14361536502838135,
-0.010663622990250587,
0.18759295344352722,
0.10365664213895798,
0.2192153036594391,
0.16918785870075226,
0.014571119099855423,
0.15554237365722656,
-0.1254902333021164,
0.05424970015883446,
-0.1845046877861023,
0.003351365216076374,
-0.12213242799043655,
-0.4420977830886841,
-0.0019041424384340644,
0.20627360045909882,
0.05689960718154907,
0.1739794760942459,
-0.36680281162261963,
-0.06173500046133995,
-0.15977101027965546,
-0.0320095494389534,
-0.036293838173151016,
0.09646157920360565,
0.0017677918076515198,
0.3260602355003357,
-0.043014537543058395,
-0.15272356569766998,
-0.11940699070692062,
-0.15888646245002747,
-0.21256205439567566,
0.1990082710981369,
0.04334619268774986,
-0.047682009637355804,
-0.22554168105125427,
-0.021387143060564995,
-0.030512575060129166,
-0.09707490354776382,
0.10152098536491394,
-0.10601678490638733,
-0.11622446030378342,
0.036825161427259445,
0.13030056655406952,
0.003268118714913726,
0.059932298958301544,
-0.007208147551864386,
-0.05932166799902916,
0.020206144079566002,
0.15042860805988312,
0.08022824674844742,
-0.07944976538419724,
0.09010348469018936,
-0.02403579093515873,
-0.31384509801864624,
-0.052401356399059296,
0.2228650152683258,
0.2531217336654663,
-0.05042056739330292,
-0.12498525530099869,
0.09369275718927383,
-0.08276745676994324,
-0.01977892406284809,
0.08559178560972214,
0.06843232363462448,
-0.12942302227020264,
0.058587729930877686,
-0.06354491412639618,
-0.06142698600888252,
-0.026280056685209274,
-0.2761226296424866,
-0.07972512394189835,
0.031410183757543564,
-0.022585038095712662,
0.0002879194507841021,
-0.16348929703235626,
-0.03141780570149422,
-0.02215012162923813,
-0.05678166076540947,
-0.04619763419032097,
0.10218311101198196,
0.0007468577241525054,
0.24402204155921936,
-0.23432792723178864,
0.010778185911476612,
-0.023126186802983284,
0.04946732148528099,
-0.07908239215612411,
-0.08826686441898346,
-0.19374562799930573,
0.06137187406420708,
0.1515546292066574,
-0.05751670151948929,
-0.10791465640068054,
0.09483502060174942,
0.09660699963569641,
0.20114700496196747,
0.13627982139587402,
0.3161397874355316,
0.16636411845684052,
-0.0701354444026947,
-0.0012175077572464943,
0.16664861142635345,
0.10869091004133224,
-0.034905802458524704,
-0.0699615478515625,
0.2138354629278183,
-0.11925996094942093,
0.25091227889060974,
0.03494972735643387,
0.03240806981921196,
-0.0004723363381344825,
-0.014842377044260502,
0.0093257250264287,
-0.16431978344917297,
0.06598246097564697,
0.08539056032896042,
-0.05580070614814758,
0.008998479694128036,
-0.14753472805023193,
-0.044229656457901,
0.10697769373655319,
-0.06840602308511734,
-0.05918671563267708,
0.08485813438892365,
0.01036522164940834,
-0.09866175800561905,
0.04931327700614929,
-0.07491049915552139,
0.13469240069389343,
-0.07830934971570969,
-0.0684686228632927,
0.013954615220427513,
0.05399810150265694,
0.025183815509080887,
0.1556873768568039,
0.012479476630687714,
-0.07743753492832184,
-0.022977977991104126,
-0.25130265951156616,
-0.10452926903963089,
-0.08289096504449844,
-0.08683469891548157,
0.1985035091638565,
-0.27042070031166077,
-0.023776404559612274,
0.0657864436507225,
-0.07920467108488083,
-0.03621779382228851,
-0.17709876596927643,
0.08952505141496658,
-0.22651726007461548,
-0.044269781559705734,
-0.06841795891523361,
0.04059058055281639,
0.121566042304039,
0.20739910006523132,
-0.09868046641349792,
0.08537503331899643,
-0.0187249556183815,
0.12010648101568222,
0.050760865211486816,
-0.029526619240641594,
-0.08925535529851913,
0.052363984286785126,
0.20376867055892944,
0.0028592513408511877,
0.3346501588821411,
-0.19935189187526703,
0.1631208211183548,
-0.00912629533559084,
-0.04801405593752861,
0.015012898482382298,
-0.1252707839012146,
0.09300938993692398,
0.14290449023246765,
-0.14602060616016388,
0.1441899538040161,
-0.11746980994939804,
-0.22688426077365875,
-0.14175397157669067,
0.14332528412342072,
-0.09652374684810638,
0.04291990399360657,
-0.04122791811823845,
0.05918939411640167,
-0.12261319160461426,
-0.026290666311979294,
-0.1014164462685585,
0.09674925357103348,
0.07180289179086685,
-0.09685821831226349,
-0.01644572988152504,
0.22654391825199127,
-0.11217832565307617,
0.13154098391532898,
-0.2033262550830841,
0.04764818400144577,
0.0651785284280777,
0.004503660835325718,
0.0035389901604503393,
0.19488193094730377,
0.059670306742191315,
0.009400369599461555,
-0.11930492520332336,
-0.21501615643501282,
-0.022939657792448997,
-0.2525840997695923,
0.06339161098003387,
0.0839027389883995,
-0.3211817145347595,
-0.13576579093933105,
0.10599660873413086,
0.05703287944197655,
0.24492526054382324,
0.04670082405209541,
0.22312839329242706,
0.017311321571469307,
0.18262046575546265,
-0.07637246698141098,
-0.12144925445318222,
-0.15820927917957306,
-0.06536508351564407,
0.12697719037532806,
-0.06129641458392143,
-0.1993178129196167,
-0.0398746021091938,
0.24675258994102478,
0.06346552073955536,
0.11875952780246735,
-0.06448794156312943,
-0.06061842665076256,
0.05214220657944679,
0.10855910927057266,
0.11338301002979279,
-0.005469237454235554,
-0.03823589161038399,
-0.09905892610549927,
-0.1850825846195221,
0.0957944393157959,
0.2809641361236572,
-0.021513888612389565,
-0.3118475675582886,
0.05697992444038391,
0.0549282431602478,
-0.08964181691408157,
0.08064441382884979,
0.13213491439819336,
0.07413967698812485,
-0.07431627064943314,
0.04739697277545929,
0.18777143955230713,
0.009579407051205635,
-0.009766872972249985,
0.10390126705169678,
-0.06520386040210724,
0.21253183484077454,
0.06468996405601501,
-0.07568135112524033,
0.057572852820158005,
-0.05348295718431473,
-0.13398991525173187,
0.27278241515159607,
-0.053764622658491135,
0.01782333478331566,
-0.037932053208351135,
-0.3310067653656006,
0.17324385046958923,
0.15349608659744263,
0.24520789086818695,
-0.014496495015919209,
0.060668911784887314,
-0.17098931968212128,
0.0905279666185379,
0.20260454714298248,
-0.0040995050221681595,
-0.05703271925449371,
-0.2079741507768631,
0.0370812825858593,
-0.0071524460799992085,
0.08241280913352966,
0.07900197058916092,
-0.061504848301410675,
0.241755411028862,
-0.0009410979109816253,
-0.03603686764836311,
-0.0814620703458786,
0.049184344708919525,
-0.07993593066930771,
-0.04287334531545639,
0.11289826035499573,
0.09171988815069199,
0.06359796226024628,
-0.13120593130588531,
-0.14745615422725677,
-0.11256460100412369,
-0.09924834966659546,
-0.2799050211906433,
-0.09613723307847977,
-0.004057738464325666,
-0.018367929384112358,
0.011086659505963326,
-0.11533656716346741,
0.13552892208099365,
-0.15273360908031464,
-0.13845305144786835,
0.0004019086482003331,
-0.17089876532554626,
0.035161878913640976,
-0.35748597979545593,
0.17601461708545685,
0.013586006127297878,
0.16109620034694672,
0.15169063210487366,
-0.0276815053075552,
0.10398897528648376,
-0.08136019855737686,
0.004493905697017908,
-0.09831341356039047,
0.0083561846986413,
-0.1568572074174881,
-0.07693462818861008,
-0.20837616920471191,
0.055534396320581436,
0.0746220052242279,
0.09169379621744156,
0.40961992740631104,
0.007641283795237541,
0.12926216423511505,
-0.00731221679598093,
0.002424520207569003,
0.10287898778915405,
-0.19069968163967133,
0.05532843992114067,
-0.20407064259052277,
-0.22716182470321655,
-0.03249863162636757,
0.040047869086265564,
0.19499637186527252,
-0.160055473446846,
-0.20598751306533813,
0.07069569826126099,
-0.19859835505485535,
0.1910334974527359,
0.06448452174663544,
-0.11645764112472534,
0.18046881258487701,
-0.030815698206424713,
0.01751507818698883,
0.027572179213166237,
0.021520711481571198,
-0.10226531326770782,
0.10664037615060806,
-0.22732971608638763,
-0.2524816393852234,
-0.08561883121728897,
0.04439631849527359,
-0.11138273030519485,
-0.051793817430734634,
0.20726557075977325,
0.028952086344361305,
-0.022130250930786133,
-0.012940596789121628,
-0.026981929317116737,
-0.09462184458971024,
0.333573579788208,
-0.2143251895904541,
0.04711432382464409,
-0.1557316929101944,
-0.11649671941995621,
-0.16171462833881378,
-0.1978164166212082,
0.11279632896184921,
0.08197725564241409,
0.055285412818193436,
-0.04603074491024017,
0.1654151976108551,
-0.05987642705440521,
-0.012382560409605503,
-0.1699177771806717,
-0.12083745747804642,
0.13033367693424225,
-0.0072013926692306995,
0.013593969866633415,
-0.17184586822986603,
0.14701436460018158,
0.26504844427108765,
0.025797629728913307,
-0.27336591482162476,
0.11161022633314133,
0.09595339745283127,
0.1781119555234909,
0.1225370392203331,
0.010164127685129642,
0.10779747366905212,
-0.04729122668504715,
0.23691490292549133,
0.1430020034313202,
0.05912889540195465,
0.07160168141126633,
-0.01641952618956566,
0.0969749391078949,
-0.09472446143627167,
0.1852208524942398,
-0.008630026131868362,
0.008991370908915997,
-0.020050164312124252,
0.04140518233180046,
0.17368149757385254,
-0.08036048710346222,
-0.02841169945895672,
0.10819277912378311,
0.09608574956655502,
0.03478097543120384,
-0.14135631918907166,
-0.08990831673145294,
-0.01243628840893507,
0.029080938547849655,
0.2656864821910858,
-0.1518985480070114,
0.11047089099884033,
0.19307485222816467,
-0.3077308237552643,
0.058535873889923096,
0.0804099589586258,
0.008408240042626858,
-0.006005371920764446,
0.013463550247251987,
0.1582016944885254,
-0.03415938466787338,
-0.17954447865486145,
-0.07906731963157654,
0.12181352078914642,
-0.07004024088382721,
-0.04586134850978851,
0.10204523056745529,
0.24859702587127686,
0.13104362785816193,
0.04704819992184639,
-0.030403947457671165,
0.07570017874240875,
0.02585560642182827,
0.10855204612016678,
-0.14094002544879913,
0.31633296608924866,
-0.18503199517726898,
0.19140000641345978,
-0.06709527224302292,
0.051479119807481766,
0.20572441816329956,
0.051472924649715424,
-0.02853391505777836,
0.2002754807472229,
-0.07683425396680832,
-0.07422570139169693,
-0.16554301977157593,
0.02216852642595768,
0.051436301320791245,
0.04164624586701393,
0.09964564442634583,
-0.03955543413758278,
-0.007488716393709183,
-0.026459915563464165,
-0.3063438832759857,
-0.14524070918560028,
0.0737481489777565,
-0.15820623934268951,
-0.08985186368227005,
-0.0488700307905674,
-0.27016502618789673,
0.10059019923210144,
-0.09684408456087112,
-0.12465763092041016,
0.036182697862386703,
0.07933469116687775,
0.04963405430316925,
0.03942972049117088,
-0.08081028610467911,
0.02801753766834736,
-0.0006633390439674258,
-0.05177346616983414,
-0.08087056875228882,
-0.15879620611667633,
0.32959526777267456,
-0.11383943259716034,
-0.019889837130904198,
-0.11699749529361725,
-0.16106170415878296,
-0.02725156769156456,
0.06580184400081635,
0.0782710462808609,
0.07281330227851868,
0.10285717993974686,
-0.08699248731136322,
-0.004733415320515633,
0.16187599301338196,
-0.2211488038301468,
0.2600075602531433,
0.09008077532052994,
-0.0763135775923729,
-0.05986941233277321,
-0.025961389765143394,
0.05934238061308861,
0.03347761183977127,
-0.07147739827632904,
0.299075186252594,
0.02809395082294941,
-0.10639049112796783,
-0.032345179468393326,
-0.046542517840862274,
-0.1322157382965088,
-0.06168339028954506,
0.059136729687452316,
0.0002177348651457578,
-0.17146341502666473,
0.19931046664714813,
-0.049462515860795975,
0.2256227284669876,
-0.06779574602842331,
-0.08709052950143814,
0.09654256701469421,
0.18649822473526,
0.1485053151845932,
0.08927907049655914,
-0.012996992096304893,
0.10800667107105255,
-0.14705818891525269,
-0.13441678881645203,
0.18727467954158783,
-0.25485894083976746,
-0.0503176786005497,
-0.05410361662507057,
-0.1122015044093132,
-0.08797504007816315,
-0.289813756942749,
0.2417362630367279,
0.07864860445261002,
-0.18696576356887817,
0.03463098406791687,
-0.1710643768310547,
0.042807500809431076,
0.23671095073223114,
-0.13268950581550598,
0.10673022270202637,
0.3487515151500702,
0.023599036037921906,
-0.07932952791452408,
0.011307938024401665,
-0.023712385445833206,
-0.00022613843611907214,
0.1758488416671753,
-0.012407868169248104,
0.3160923421382904,
-0.016227420419454575,
0.11849004775285721,
-0.02674320712685585,
-0.005532493814826012,
0.12579119205474854,
-0.13156451284885406,
-0.1392631083726883,
0.023373978212475777,
0.02335965260863304,
0.08677166700363159,
-0.20003323256969452,
0.3554410934448242,
-0.1514466106891632,
-0.13980089128017426,
-0.3514224588871002,
-0.1569482386112213,
0.0387333407998085,
0.08760426193475723,
-0.11498674750328064,
0.17144489288330078,
-0.022478114813566208,
0.25924450159072876,
0.03209666162729263,
0.20898495614528656,
0.010869795456528664,
0.14033763110637665,
-0.24665464460849762,
-0.11336185783147812,
0.3065573275089264,
0.03702688589692116,
-0.09299270808696747,
0.13529925048351288,
-0.050543077290058136,
0.07912737876176834,
0.06184105575084686,
-0.06394865363836288,
0.11434024572372437,
-0.03759219869971275,
0.0759650468826294,
-0.05901531130075455,
-0.017804386094212532,
0.0003350824990775436,
-0.14324137568473816,
-0.06702303886413574,
0.0026572393253445625,
-0.033498845994472504,
0.12161527574062347,
-0.28462210297584534,
0.25984036922454834,
-0.08378570526838303,
-0.024983631446957588,
-0.1725006401538849,
-0.28295010328292847,
-0.06265618652105331,
0.023557713255286217,
0.12264136970043182,
0.08490604907274246,
-0.021958256140351295,
-0.10052928328514099,
0.17677022516727448,
-0.011264732107520103,
0.07720072567462921,
0.07173724472522736,
-0.12984490394592285,
-0.06564484536647797,
-0.1641734093427658,
0.07090655714273453,
-0.00036860789987258613,
0.12087132036685944,
0.077483631670475,
-0.0040702419355511665,
-0.30643197894096375,
-0.2971084415912628,
-0.2383366823196411,
0.16501368582248688,
0.129781112074852,
-0.0140385078266263,
-0.009327688254415989,
-0.011611135676503181,
0.2234850376844406,
-0.17845889925956726,
0.10615381598472595,
0.464168518781662,
-0.0622270330786705,
-0.300518274307251,
-0.21543848514556885,
-0.035143181681632996,
0.10717515647411346,
0.09570226818323135,
-0.03644632175564766,
-0.008951370604336262,
0.16224144399166107,
0.04639134928584099,
-0.049779437482357025,
-0.05130987986922264,
-0.08165499567985535,
0.033764198422431946,
-0.018671145662665367,
-0.1997513771057129,
0.44074729084968567,
-0.039922915399074554,
0.030248388648033142,
-0.011923598125576973,
-0.1878392994403839,
0.1233183816075325,
0.020464273169636726,
0.1394621878862381,
0.10982318222522736,
-0.23841315507888794,
0.1030377447605133,
-0.14620408415794373,
0.078285813331604,
-0.1748039275407791,
-0.051137905567884445,
-0.05231495574116707,
-0.035511188209056854,
0.14273563027381897,
0.06456226110458374,
0.16785280406475067,
-0.31597086787223816,
-0.06780439615249634,
-0.20018918812274933,
0.055429618805646896,
-0.08326485008001328,
-0.043019093573093414,
0.02935299463570118,
-0.08444901555776596,
0.2231929898262024,
0.05104463919997215,
-0.0034286482259631157,
-0.14770948886871338,
0.16538125276565552,
0.0349484421312809,
-0.025219295173883438,
-0.04548416659235954,
-0.08900229632854462,
0.04458315670490265,
0.13560673594474792,
0.12431252002716064,
0.08105897903442383,
0.1553637832403183,
-0.23734675347805023,
-0.26260000467300415,
0.12632927298545837,
0.0566534698009491,
-0.13055318593978882,
-0.03100416623055935,
-0.008466843515634537,
-0.17535147070884705,
-0.02904668264091015,
0.046058863401412964,
-0.041684407740831375,
-0.0006915163830853999,
0.00688139395788312,
0.17217721045017242,
0.012409734539687634,
0.031654242426157,
-0.22011210024356842,
-0.04987498000264168,
-0.17335061728954315,
-0.15175479650497437,
-0.05224716290831566,
0.16125284135341644,
-0.14119108021259308,
-0.24836459755897522,
-0.0535411462187767,
0.030585939064621925,
-0.1469155102968216,
0.10212566703557968,
0.044448371976614,
-0.046947184950113297
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. diagnosis.PTEN hamartoma tumor syndrome
(PHTS) is a heterogeneous disorder that manifests asymmetric overgrowth, macrocephaly, cutaneous vascular malformations, and tumor susceptibility. The full spectrum of this interesting and distinctive disorder is not known, but it can be readily distinguished from PS. A phenotypic subtype, described as type II segmental Cowden syndrome or SOLAMEN syndrome , is the consequence of a germline pathogenic variant in PTEN with a somatic, mosaic second PTEN variant that gives the phenotype its segmental attributes.PTHS includes growth abnormalities with linear nevi and vascular malformations that are clinically and molecularly distinct from those of PS.PTHS is inherited in an autosomal dominant manner; PS is not inherited. Thus, the genetic implications in the two disorders are quite distinct, providing further argument for a clear distinction between individuals affected with PS and those with PTHS.CLOVE(S) syndrome (congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations | [
-0.21937595307826996,
-0.07648271322250366,
0.04663536325097084,
-0.13381390273571014,
0.11242259293794632,
-0.0018775609787553549,
-0.07193949073553085,
-0.22970692813396454,
-0.12140600383281708,
0.036952972412109375,
0.22249528765678406,
-0.041450418531894684,
-0.13222631812095642,
0.0727362334728241,
-0.15100301802158356,
0.4198737144470215,
-0.17925673723220825,
0.08408129960298538,
-0.01775597408413887,
0.055230483412742615,
0.056430377066135406,
-0.08882924169301987,
0.07285405695438385,
0.04275817051529884,
-0.01487015187740326,
-0.3332046866416931,
0.18784956634044647,
0.16117210686206818,
-0.00692725507542491,
0.007822763174772263,
0.11656085401773453,
-0.04367518052458763,
-0.013754970394074917,
-0.2875007390975952,
-0.0038148860912770033,
-0.14532406628131866,
-0.13455308973789215,
-0.04299278184771538,
0.1048409640789032,
-0.0842415988445282,
-0.059216782450675964,
0.07084756344556808,
-0.03747040033340454,
-0.16547437012195587,
0.1993516981601715,
-0.1238509938120842,
-0.03558165580034256,
0.1399562507867813,
0.07686685025691986,
0.1659068465232849,
0.17615710198879242,
0.08940433710813522,
0.19468176364898682,
-0.2272804230451584,
0.06043590232729912,
-0.16714899241924286,
-0.0036379811353981495,
-0.03797149658203125,
-0.37850162386894226,
0.020099934190511703,
0.1539144366979599,
0.08208203315734863,
0.16108198463916779,
-0.4365856647491455,
-0.08274058997631073,
-0.10921724885702133,
-0.11441096663475037,
-0.010222714394330978,
0.07287761569023132,
0.04541367292404175,
0.2966492772102356,
0.0014753813156858087,
-0.16501978039741516,
-0.10941217094659805,
-0.10664909332990646,
-0.1719314455986023,
0.1301334947347641,
0.055707529187202454,
-0.06582827121019363,
-0.20571304857730865,
0.05684630945324898,
-0.03339909017086029,
-0.15401305258274078,
0.1411607712507248,
-0.08426206558942795,
-0.18559254705905914,
0.10372388362884521,
0.04432564973831177,
-0.09946952015161514,
-0.037372734397649765,
0.0009780017426237464,
-0.03424053266644478,
0.10157554596662521,
0.1832658052444458,
0.04213269054889679,
-0.0846577137708664,
0.02455134131014347,
-0.051337484270334244,
-0.27783262729644775,
-0.00992896594107151,
0.18162383139133453,
0.13217444717884064,
-0.051522452384233475,
-0.19591471552848816,
0.018055567517876625,
-0.04327933490276337,
0.043328817933797836,
0.020513027906417847,
0.13083146512508392,
-0.15253424644470215,
0.06716105341911316,
-0.040785640478134155,
-0.06324760615825653,
-0.1299828588962555,
-0.26878347992897034,
-0.11939749121665955,
0.0866142138838768,
-0.019252289086580276,
0.01538977213203907,
-0.14885172247886658,
-0.10282240062952042,
0.03212073817849159,
0.04428774118423462,
-0.0830894336104393,
0.10531961917877197,
-0.021285008639097214,
0.1940881609916687,
-0.22198741137981415,
0.07058706879615784,
0.03535900637507439,
0.09186762571334839,
-0.1785099357366562,
-0.1056884154677391,
-0.09888552874326706,
0.05400931090116501,
0.11348745971918106,
-0.08843857049942017,
-0.18098551034927368,
0.036580849438905716,
0.09624196588993073,
0.2416447252035141,
0.010168219916522503,
0.2754085958003998,
0.31421977281570435,
-0.12667113542556763,
0.022753866389393806,
0.12627871334552765,
0.14635097980499268,
-0.053341466933488846,
-0.020631901919841766,
0.21996773779392242,
-0.06025395542383194,
0.1377827376127243,
-0.0004678544355556369,
0.0380074717104435,
0.07779484987258911,
0.0626334398984909,
0.058111801743507385,
-0.19543291628360748,
0.013477146625518799,
0.1279439777135849,
-0.1595107913017273,
-0.05963971093297005,
-0.030247125774621964,
-0.024482429027557373,
0.14245492219924927,
-0.11443160474300385,
-0.10281512141227722,
0.1384083777666092,
-0.07635056972503662,
-0.08060707896947861,
0.05015524476766586,
-0.029497701674699783,
0.09214165061712265,
-0.011756358668208122,
-0.10042903572320938,
0.06766734272241592,
-0.05630261078476906,
0.05922280251979828,
0.06862520426511765,
-0.03556720167398453,
-0.1202806904911995,
0.030016092583537102,
-0.23998861014842987,
-0.07224863022565842,
-0.03243060037493706,
-0.07759973406791687,
0.19894208014011383,
-0.16712550818920135,
-0.013372605666518211,
0.12328480929136276,
-0.08062314242124557,
0.053501859307289124,
-0.1899324506521225,
0.14635391533374786,
-0.17479629814624786,
-0.005506383720785379,
0.008849669247865677,
0.05561370402574539,
0.08737717568874359,
0.22637897729873657,
-0.06358736753463745,
0.0787530466914177,
0.0027128153014928102,
0.09276454895734787,
0.04622951149940491,
-0.027111167088150978,
0.012035511434078217,
0.07154580950737,
0.24197396636009216,
0.03502844274044037,
0.3261227011680603,
-0.1455114483833313,
0.12809115648269653,
-0.02715068683028221,
0.033566661179065704,
-0.11555315554141998,
-0.13880839943885803,
0.13762034475803375,
0.05199113488197327,
-0.05000133439898491,
0.1502968817949295,
-0.08655296266078949,
-0.30749598145484924,
-0.1592707633972168,
0.17572690546512604,
-0.1365460604429245,
0.03955845534801483,
-0.14136241376399994,
0.09894860535860062,
-0.14766690135002136,
-0.05027247220277786,
-0.1362188756465912,
0.04551274701952934,
0.04251369461417198,
-0.07323688268661499,
-0.02430366538465023,
0.1876957267522812,
-0.12108765542507172,
0.14320793747901917,
-0.1950557827949524,
0.018696825951337814,
-0.002580171450972557,
0.08771087229251862,
-0.01118199247866869,
0.1906537562608719,
0.027924794703722,
-0.0890803411602974,
-0.0688413754105568,
-0.20065318048000336,
-0.00385816371999681,
-0.17707660794258118,
0.12569767236709595,
0.058777034282684326,
-0.3156096935272217,
-0.020951097831130028,
0.04474092274904251,
0.08492545038461685,
0.2262483686208725,
0.1233212798833847,
0.25348344445228577,
-0.059532977640628815,
0.0009951600804924965,
-0.026881428435444832,
-0.15683303773403168,
-0.0837457999587059,
-0.08125513046979904,
0.10984408855438232,
-0.0896894782781601,
-0.1526642143726349,
-0.15107737481594086,
0.20419740676879883,
0.03255411237478256,
0.03998228535056114,
-0.03559284284710884,
-0.01892876625061035,
0.025733958929777145,
0.07683824747800827,
0.06275640428066254,
0.017225928604602814,
-0.012849265709519386,
-0.08525994420051575,
-0.16386280953884125,
0.06970515102148056,
0.2324826866388321,
-0.016197023913264275,
-0.29653534293174744,
-0.04354897886514664,
0.024010589346289635,
-0.10982054471969604,
0.07519268244504929,
0.06573596596717834,
0.05178434029221535,
-0.03160878270864487,
0.06252680718898773,
0.22309373319149017,
-0.02881196327507496,
-0.03511501103639603,
0.11036378145217896,
-0.04951981082558632,
0.14063622057437897,
0.11518112570047379,
-0.05414769798517227,
0.1153828501701355,
-0.010406075976788998,
-0.10101298242807388,
0.2394324094057083,
-0.06594917178153992,
-0.01011531800031662,
-0.051571376621723175,
-0.40776482224464417,
0.20281019806861877,
0.1124095767736435,
0.24802789092063904,
-0.04945501685142517,
0.07994682341814041,
-0.07753142714500427,
0.13847024738788605,
0.191923126578331,
-0.10324398428201675,
-0.07487955689430237,
-0.252177357673645,
0.022274194285273552,
0.10393454879522324,
0.14768943190574646,
0.013431045226752758,
0.019863072782754898,
0.19232803583145142,
0.009354991838335991,
-0.027396809309720993,
0.004737022798508406,
0.029249342158436775,
-0.11315946280956268,
0.005778829101473093,
0.13001985847949982,
0.1437455266714096,
0.07584374397993088,
-0.10845590382814407,
-0.18583349883556366,
-0.14545106887817383,
-0.02306564524769783,
-0.26559019088745117,
-0.1506073772907257,
-0.003184597473591566,
0.03282666206359863,
0.05508101359009743,
-0.08530796319246292,
0.23337490856647491,
-0.04181886091828346,
-0.19858525693416595,
0.02394871972501278,
-0.10171698033809662,
-0.05384138971567154,
-0.34320712089538574,
0.05577531456947327,
0.010873260907828808,
0.07772552222013474,
0.0970354676246643,
0.017426081001758575,
0.14544577896595,
-0.016986146569252014,
-0.01602506823837757,
-0.05053050071001053,
0.044808294624090195,
-0.1399437040090561,
-0.09006340801715851,
-0.18569472432136536,
0.06158621981739998,
0.0460885725915432,
0.15154965221881866,
0.3794540464878082,
0.08652277290821075,
0.15197062492370605,
0.018700091168284416,
0.025616254657506943,
0.10785966366529465,
-0.20223689079284668,
0.09152078628540039,
-0.17769157886505127,
-0.10593534260988235,
-0.031619444489479065,
-0.011891555972397327,
0.15359707176685333,
-0.12447144836187363,
-0.13960188627243042,
0.10923145711421967,
-0.19289371371269226,
0.2302873432636261,
0.12548375129699707,
-0.12955084443092346,
0.13011404871940613,
0.0013701901771128178,
0.04139941558241844,
-0.07230377197265625,
0.003451545489951968,
-0.1518642008304596,
0.15966901183128357,
-0.23755314946174622,
-0.27171504497528076,
-0.0548463836312294,
0.10594673454761505,
-0.12332087755203247,
-0.0022885326761752367,
0.26642289757728577,
0.023961825296282768,
0.04007819667458534,
0.020190682262182236,
-0.10275977104902267,
-0.048785500228405,
0.3618153929710388,
-0.24000076949596405,
0.04535101354122162,
-0.2304191142320633,
0.014990048483014107,
-0.15733124315738678,
-0.24685102701187134,
0.19974328577518463,
0.032798778265714645,
0.09629155695438385,
-0.05729125812649727,
0.07410378009080887,
-0.03457067534327507,
0.018358580768108368,
-0.23935125768184662,
-0.14349105954170227,
0.06546297669410706,
0.02052723988890648,
-0.02525976486504078,
-0.12523773312568665,
0.16766990721225739,
0.2322205901145935,
0.07786183804273605,
-0.2912212908267975,
0.17062419652938843,
0.14981140196323395,
0.2861625850200653,
0.24983865022659302,
0.1041116937994957,
0.16190481185913086,
-0.0767064318060875,
0.19721391797065735,
0.11827690154314041,
-0.059568747878074646,
0.13918587565422058,
0.029299382120370865,
0.03997132182121277,
-0.0675453320145607,
0.2804785370826721,
0.005063194315880537,
-0.05700987949967384,
0.02228488400578499,
-0.08382965624332428,
0.22842314839363098,
0.005129524506628513,
-0.06110871955752373,
0.07845139503479004,
0.05697062611579895,
-0.052759066224098206,
-0.1434057354927063,
-0.10399516671895981,
-0.002893873956054449,
-0.04285074770450592,
0.3303367793560028,
-0.13515879213809967,
0.21343614161014557,
0.14484435319900513,
-0.2928139567375183,
0.049264706671237946,
0.1474331021308899,
0.03268147632479668,
-0.0037498187739402056,
-0.03492054343223572,
0.12479116767644882,
-0.014975222758948803,
-0.06789524108171463,
0.007697956636548042,
0.18368470668792725,
-0.1295827478170395,
-0.014694683253765106,
0.1568608582019806,
0.2385556995868683,
0.15603213012218475,
-0.07278145849704742,
-0.060424286872148514,
0.13855397701263428,
0.02275296300649643,
0.0628868117928505,
-0.19747430086135864,
0.3889312148094177,
-0.11531219631433487,
0.16391205787658691,
-0.06393991410732269,
0.06467556208372116,
0.2191731035709381,
0.07030081003904343,
0.0020507171284407377,
0.18992114067077637,
0.012909974902868271,
-0.07456263154745102,
-0.17684124410152435,
0.0838911384344101,
-0.007218333426862955,
0.01588187925517559,
0.15366341173648834,
0.003401760011911392,
-0.000500363006722182,
0.014574382454156876,
-0.27672621607780457,
-0.09176064282655716,
0.12055507302284241,
-0.10859006643295288,
-0.1376190334558487,
0.05993415415287018,
-0.2964237928390503,
0.11700349301099777,
-0.14172884821891785,
-0.08887714147567749,
0.040107086300849915,
0.1433357298374176,
0.10417050123214722,
-0.011528228409588337,
-0.1210775151848793,
0.03993035480380058,
-0.019606729969382286,
-0.1408676654100418,
-0.09918281435966492,
-0.12539467215538025,
0.4053601026535034,
-0.06940445303916931,
0.03509104624390602,
-0.14379972219467163,
-0.2203902006149292,
-0.04500403627753258,
0.03790045902132988,
0.005049415864050388,
0.10406367480754852,
0.15712584555149078,
-0.018564535304903984,
0.12167461961507797,
0.08895187824964523,
-0.2524682581424713,
0.29839789867401123,
-0.010848406702280045,
-0.11662789434194565,
-0.13335412740707397,
-0.04123426601290703,
-0.001105552539229393,
0.08246304839849472,
-0.032111164182424545,
0.2477569580078125,
0.021454034373164177,
-0.1169927790760994,
-0.020532306283712387,
-0.008439699187874794,
-0.053835269063711166,
0.0061576650477945805,
0.21300694346427917,
-0.027246644720435143,
-0.20050203800201416,
0.18194660544395447,
-0.014764121733605862,
0.24446699023246765,
-0.15914100408554077,
-0.19075390696525574,
0.12836600840091705,
0.16111363470554352,
0.18415981531143188,
0.11709969490766525,
0.02976614609360695,
0.009712440893054008,
-0.1613321751356125,
-0.1621149331331253,
0.11724037677049637,
-0.21375858783721924,
0.014449567534029484,
-0.038851216435432434,
-0.15322868525981903,
-0.10570618510246277,
-0.252991259098053,
0.27493995428085327,
0.0808175578713417,
-0.233864888548851,
0.04391395300626755,
-0.06906312704086304,
0.07358602434396744,
0.21982342004776,
-0.1396658718585968,
0.1736481636762619,
0.270130455493927,
-0.003742696950212121,
-0.089118592441082,
0.002420242642983794,
0.06971320509910583,
-0.04883482679724693,
0.24162831902503967,
0.02115820161998272,
0.25432220101356506,
-0.05866149440407753,
0.07127288728952408,
0.0792904645204544,
-0.04572955518960953,
0.14632606506347656,
-0.15526458621025085,
-0.16872838139533997,
0.04060541093349457,
0.12364088743925095,
0.14062216877937317,
-0.14701704680919647,
0.3606666922569275,
-0.17054855823516846,
-0.1652251034975052,
-0.42952871322631836,
-0.12957851588726044,
-0.013719931244850159,
0.09109100699424744,
-0.12102155387401581,
0.16406212747097015,
0.05188789218664169,
0.15216319262981415,
0.16595663130283356,
0.23039141297340393,
0.09949055314064026,
0.15296150743961334,
-0.14356514811515808,
-0.05076008662581444,
0.3378649055957794,
0.059772882610559464,
-0.1039254292845726,
0.13530965149402618,
-0.05321621149778366,
0.05209893360733986,
0.02722490020096302,
-0.08108003437519073,
0.09803826361894608,
-0.05031916871666908,
0.13393977284431458,
-0.12380480766296387,
0.05086236074566841,
0.041794586926698685,
-0.1607588827610016,
-0.050684310495853424,
-0.059056635946035385,
-0.03605791926383972,
0.13816401362419128,
-0.17864099144935608,
0.2764482796192169,
-0.053782910108566284,
-0.01633569784462452,
-0.13529835641384125,
-0.29392945766448975,
-0.029745517298579216,
0.04281897097826004,
0.21203632652759552,
0.14304396510124207,
-0.12521998584270477,
-0.12549033761024475,
0.1642058938741684,
-0.08848504722118378,
0.02404279075562954,
0.07715445011854172,
-0.2740400731563568,
-0.17497897148132324,
-0.19396845996379852,
0.07406479865312576,
0.03514748066663742,
0.12592822313308716,
0.04652242735028267,
-0.0346735417842865,
-0.30492469668388367,
-0.25052618980407715,
-0.1702297180891037,
0.08612211048603058,
0.20038442313671112,
0.03573537990450859,
0.09568439424037933,
-0.008008350618183613,
0.16014733910560608,
-0.013087434694170952,
0.07388465106487274,
0.4090019762516022,
-0.11144740879535675,
-0.24187523126602173,
-0.21710355579853058,
0.0020719668827950954,
0.1747094988822937,
0.09597089886665344,
0.010031519457697868,
0.04433662071824074,
0.1264127939939499,
0.016109956428408623,
-0.09845568239688873,
-0.05089770630002022,
-0.03338002413511276,
0.08748059719800949,
-0.07236373424530029,
-0.12687838077545166,
0.3364373743534088,
-0.06263372302055359,
0.05724624544382095,
0.064143106341362,
-0.2150358408689499,
0.1227676197886467,
0.11399377137422562,
0.096868135035038,
0.12936443090438843,
-0.273701548576355,
0.14069345593452454,
-0.10313229262828827,
0.017211930826306343,
-0.16744858026504517,
-0.07875463366508484,
-0.023621181026101112,
-0.12069337069988251,
0.13405893743038177,
0.07467680424451828,
0.07438332587480545,
-0.343463271856308,
-0.15725867450237274,
-0.24093343317508698,
0.11554199457168579,
-0.10672163218259811,
-0.10912643373012543,
0.01057075709104538,
-0.04820176586508751,
0.24232639372348785,
0.20078957080841064,
0.00905496347695589,
-0.21309292316436768,
0.19308511912822723,
0.032292574644088745,
-0.06283248960971832,
-0.07140149176120758,
-0.09083471447229385,
-0.020172106102108955,
0.1749224215745926,
0.1471099704504013,
0.01896507851779461,
0.11118156462907791,
-0.23217828571796417,
-0.2981843650341034,
0.041861992329359055,
0.06452116370201111,
-0.20437146723270416,
0.07239991426467896,
0.03439226746559143,
-0.1917664110660553,
0.004865092691034079,
0.0452527217566967,
-0.029322821646928787,
-0.011940195225179195,
0.040570467710494995,
0.17782318592071533,
-0.005040290765464306,
-0.03097296506166458,
-0.17229115962982178,
-0.021656429395079613,
-0.10857448726892471,
-0.1748303771018982,
-0.035655613988637924,
0.18035918474197388,
-0.1445688158273697,
-0.25141024589538574,
-0.034626781940460205,
-0.00422160467132926,
0.0001781900937203318,
0.09421463310718536,
0.05027799680829048,
-0.013852055184543133
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. attributes.PTHS includes growth abnormalities with linear nevi and vascular malformations that are clinically and molecularly distinct from those of PS.PTHS is inherited in an autosomal dominant manner; PS is not inherited. Thus, the genetic implications in the two disorders are quite distinct, providing further argument for a clear distinction between individuals affected with PS and those with PTHS.CLOVE(S) syndrome (congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies) is one of several now-distinct entities previously included in the heterogeneous designation of PS . It manifests prenatal asymmetric overgrowth that is primarily proportionate in nature. Affected persons commonly have splayed feet and toes. The vascular malformations are most commonly combined lymphatico-venous anomalies with cutaneous blebbing and weeping. The lipomatous nature of the overgrowth is characterized by overgrowth of fat within normal fatty fascial planes and linear | [
-0.16792480647563934,
-0.04661521688103676,
0.03625841438770294,
-0.10263148695230484,
0.05543388053774834,
-0.11435288935899734,
0.09019387513399124,
-0.11733527481555939,
-0.020383713766932487,
-0.1277262419462204,
0.06784521788358688,
0.19873565435409546,
-0.14347101747989655,
0.16187125444412231,
-0.09460007399320602,
0.49888038635253906,
-0.024074455723166466,
0.009196949191391468,
0.024401677772402763,
-0.1279180496931076,
-0.10069816559553146,
-0.03164824843406677,
-0.08040512353181839,
-0.05266650393605232,
0.05932694673538208,
-0.07202108949422836,
0.2748066186904907,
0.24874618649482727,
0.06087159365415573,
-0.017939968034625053,
-0.04764328524470329,
-0.14607451856136322,
-0.010920464992523193,
-0.3404179811477661,
0.19098177552223206,
-0.15357695519924164,
-0.16757330298423767,
-0.08150557428598404,
0.04037037864327431,
-0.2752375900745392,
-0.0868360847234726,
0.10031483322381973,
-0.2616708278656006,
-0.12899212539196014,
0.14884917438030243,
0.08451350033283234,
-0.12717337906360626,
0.3362557291984558,
0.03690788894891739,
0.20298907160758972,
0.1511201560497284,
0.24740158021450043,
0.04290106147527695,
-0.040839195251464844,
0.08483501523733139,
-0.22916218638420105,
-0.12833645939826965,
0.004909873940050602,
-0.4092419445514679,
0.11207951605319977,
0.1593812108039856,
-0.04862229898571968,
0.11184115707874298,
-0.41299349069595337,
-0.13337202370166779,
-0.16846345365047455,
-0.15400823950767517,
0.17374081909656525,
0.03979672119021416,
0.2897665798664093,
0.3757810592651367,
-0.23276782035827637,
-0.24943864345550537,
-0.2426743358373642,
-0.12271091341972351,
-0.013217209838330746,
-0.029447784647345543,
-0.0849546492099762,
-0.2399808019399643,
-0.16135863959789276,
0.15811039507389069,
0.06959947198629379,
-0.14443475008010864,
0.05257765203714371,
-0.178471639752388,
-0.18660208582878113,
0.08629165589809418,
-0.13282765448093414,
0.018086746335029602,
0.014893065206706524,
0.14162564277648926,
-0.021811453625559807,
0.2338276207447052,
-0.06407799571752548,
0.04072786122560501,
-0.10556511580944061,
-0.012944367714226246,
-0.0694027841091156,
-0.1560106724500656,
0.0835370197892189,
0.14067131280899048,
0.14611998200416565,
0.050921618938446045,
-0.030765721574425697,
0.13591697812080383,
-0.06159922108054161,
-0.018741969019174576,
0.08906775712966919,
0.1709911823272705,
-0.066124327480793,
-0.030228883028030396,
-0.11896216869354248,
-0.16707506775856018,
-0.16877402365207672,
-0.39024704694747925,
-0.16394129395484924,
0.11060760170221329,
0.08860655874013901,
-0.00653732568025589,
-0.3745385706424713,
-0.16668391227722168,
0.008131083101034164,
0.13684166967868805,
0.03308871015906334,
0.03882278501987457,
0.028930051252245903,
0.20963801443576813,
-0.22526612877845764,
0.03512727469205856,
-0.025850564241409302,
0.04702608287334442,
-0.30848678946495056,
-0.10253159701824188,
-0.27055445313453674,
-0.2258244901895523,
0.13963212072849274,
-0.1511317491531372,
-0.1264205127954483,
0.14913035929203033,
0.20894451439380646,
0.38389453291893005,
0.06912896037101746,
0.31042736768722534,
0.12625858187675476,
0.008890376426279545,
0.00990229845046997,
0.16644608974456787,
0.08574680984020233,
0.17507758736610413,
-0.03203108534216881,
0.4131636619567871,
0.04502222314476967,
0.1388908326625824,
0.057282693684101105,
0.0747278705239296,
-0.08046859502792358,
-0.081988126039505,
0.013500099070370197,
-0.11193792521953583,
-0.1452442854642868,
0.07206407189369202,
-0.17088137567043304,
-0.018081940710544586,
-0.033849168568849564,
-0.41244277358055115,
0.2074209600687027,
-0.0360679030418396,
-0.2341756671667099,
-0.09764686971902847,
-0.05060029402375221,
-0.22249643504619598,
0.005396728403866291,
-0.1745002269744873,
-0.013317879289388657,
0.10212434083223343,
-0.12495918571949005,
0.19888092577457428,
0.10571256279945374,
0.010357570834457874,
0.018669694662094116,
0.09169725328683853,
-0.06446460634469986,
-0.06346495449542999,
-0.24831199645996094,
-0.0004146086284890771,
-0.10120940208435059,
0.00515747582539916,
0.002552424091845751,
-0.09293894469738007,
-0.05574868246912956,
0.20352841913700104,
-0.08826667070388794,
0.10781566053628922,
-0.12669947743415833,
-0.10050598531961441,
-0.2575412094593048,
0.05942206829786301,
-0.0016693195793777704,
0.08533589541912079,
0.08720467239618301,
0.07470273226499557,
0.14881256222724915,
0.11458791047334671,
0.11745887994766235,
0.04199621081352234,
-0.13077829778194427,
0.05311781167984009,
-0.15816783905029297,
0.04335344210267067,
0.1532011181116104,
-0.024492774158716202,
0.2751689553260803,
-0.09523849189281464,
-0.08711667358875275,
-0.04037289693951607,
-0.03695689141750336,
-0.2161598801612854,
-0.16468477249145508,
-0.0013456613523885608,
0.07664486765861511,
0.0714680403470993,
0.180865079164505,
0.055984508246183395,
-0.2190578430891037,
-0.2765694558620453,
0.1722348928451538,
-0.035320404917001724,
0.1633085310459137,
-0.0003076119173783809,
0.17635351419448853,
-0.13423803448677063,
-0.029477758333086967,
0.12743626534938812,
0.10619281232357025,
0.08359067887067795,
-0.25368475914001465,
-0.20271098613739014,
0.24200904369354248,
-0.012612199410796165,
0.11197718977928162,
-0.1716127097606659,
0.04714106023311615,
0.08028007298707962,
-0.31534692645072937,
-0.20071040093898773,
0.12970708310604095,
-0.038126055151224136,
-0.10564325004816055,
0.12864744663238525,
-0.0961746796965599,
0.11708013713359833,
-0.10701651126146317,
0.18488450348377228,
0.11378398537635803,
-0.23153991997241974,
-0.1272599846124649,
0.11664140969514847,
0.17044992744922638,
0.020401597023010254,
0.0738038495182991,
0.22685867547988892,
0.15496158599853516,
0.212746724486351,
0.06951108574867249,
-0.2151796966791153,
-0.2731569707393646,
0.022296957671642303,
0.04799856245517731,
-0.05443170294165611,
-0.14143501222133636,
-0.13927651941776276,
0.2530008852481842,
0.19321414828300476,
0.10110601782798767,
0.02839375101029873,
0.23319581151008606,
0.019813023507595062,
-0.04752584919333458,
0.08995573222637177,
0.10314752161502838,
0.06828778982162476,
0.00037003131001256406,
-0.07838211208581924,
-0.1250637322664261,
0.1398666799068451,
0.13263091444969177,
-0.3472435772418976,
0.09796293079853058,
0.26912999153137207,
-0.031171949580311775,
0.06443281471729279,
-0.06608019024133682,
0.0698121041059494,
0.03796116262674332,
0.05637970194220543,
0.21606497466564178,
-0.02222673036158085,
-0.039842650294303894,
0.13621649146080017,
-0.04056869447231293,
0.06745293736457825,
0.10389121621847153,
-0.12549319863319397,
0.035512834787368774,
0.1781689077615738,
-0.14252127707004547,
0.13357973098754883,
0.06847742944955826,
-0.09156369417905807,
-0.1055108830332756,
-0.2902849018573761,
0.2028188705444336,
0.33529943227767944,
0.17574045062065125,
-0.027517085894942284,
-0.07302182912826538,
-0.04264344647526741,
0.1942405253648758,
0.30226120352745056,
-0.13183917105197906,
0.036020636558532715,
-0.09035344421863556,
0.027539610862731934,
0.18387281894683838,
0.01965339295566082,
-0.13088533282279968,
0.027220245450735092,
0.07732579112052917,
-0.06535278260707855,
-0.10923303663730621,
0.039281100034713745,
0.1322312355041504,
-0.09716378897428513,
-0.1419162005186081,
-0.00391362002119422,
0.1333940476179123,
-0.12451017647981644,
-0.17653092741966248,
-0.0420130155980587,
0.042699843645095825,
-0.0623399093747139,
-0.18454991281032562,
0.06173671782016754,
-0.12374047935009003,
0.20843325555324554,
0.04042850434780121,
0.06320639699697495,
0.27859580516815186,
-0.01888531818985939,
-0.34706857800483704,
-0.10793071240186691,
-0.11546946316957474,
-0.10663341730833054,
-0.30615392327308655,
-0.013341506011784077,
0.10833372920751572,
0.1628088802099228,
0.05922359228134155,
-0.01343429647386074,
-0.07809730619192123,
-0.1146373525261879,
0.05062389746308327,
-0.10546104609966278,
0.03664914518594742,
-0.12555314600467682,
0.047189660370349884,
-0.24131527543067932,
0.048640988767147064,
0.03318966552615166,
0.0004210128099657595,
0.3802036643028259,
-0.008082644082605839,
0.07757999002933502,
-0.11983895301818848,
0.0972457006573677,
-0.0730634555220604,
-0.17501306533813477,
-0.13304242491722107,
-0.22129030525684357,
-0.2553071081638336,
-0.21162818372249603,
-0.016483614221215248,
0.20977264642715454,
-0.054463233798742294,
-0.051041778177022934,
0.117713063955307,
-0.3046696186065674,
0.21227873861789703,
0.010532519780099392,
-0.14515994489192963,
0.08756605535745621,
0.0823235958814621,
-0.010474445298314095,
0.17869538068771362,
-0.019117577001452446,
-0.11122383922338486,
0.11935277283191681,
-0.327719509601593,
-0.18993012607097626,
-0.0017980390693992376,
0.03043852187693119,
-0.08621300756931305,
0.07369014620780945,
0.14259913563728333,
0.18083706498146057,
0.11194691061973572,
-0.0785875990986824,
0.05937889963388443,
0.03085148334503174,
0.44911977648735046,
-0.2923189103603363,
-0.013377325609326363,
-0.05676174536347389,
0.03531905636191368,
-0.17653000354766846,
-0.2134900987148285,
0.06807617098093033,
-0.08326096087694168,
0.23568430542945862,
-0.05057355388998985,
0.03865750879049301,
-0.19780057668685913,
0.2411399483680725,
-0.09013266861438751,
-0.24045343697071075,
0.08698715269565582,
0.027087675407528877,
-0.17211847007274628,
-0.1256878525018692,
-0.02478179521858692,
0.3580755591392517,
0.10930874943733215,
-0.3491167724132538,
0.15847519040107727,
0.11392700672149658,
0.14055080711841583,
0.06722354143857956,
0.2024826556444168,
0.3002830743789673,
-0.02843533642590046,
0.14870144426822662,
0.1521846055984497,
0.14607200026512146,
0.22833232581615448,
0.036490168422460556,
0.11668393760919571,
-0.021869787946343422,
0.10411050915718079,
-0.011188610456883907,
0.09657496958971024,
0.05614566430449486,
0.010936986654996872,
0.26362499594688416,
-0.00033790964516811073,
0.13929666578769684,
0.022028649225831032,
-0.1075182631611824,
0.008360374718904495,
-0.23215162754058838,
0.06090785190463066,
0.16604895889759064,
0.16890792548656464,
0.3543972373008728,
0.1110043078660965,
0.05520001798868179,
0.21729998290538788,
-0.36122408509254456,
0.015468327328562737,
0.09836120903491974,
0.04741154983639717,
0.05075564235448837,
-0.009800620377063751,
0.16142280399799347,
-0.09151406586170197,
-0.1000007688999176,
0.18362712860107422,
-0.027684275060892105,
-0.09246312826871872,
-0.2006850391626358,
0.2209760695695877,
0.10116609930992126,
0.083102285861969,
-0.10690419375896454,
-0.02197188138961792,
0.2673038840293884,
0.09681139141321182,
0.13332127034664154,
-0.13273721933364868,
0.30114805698394775,
-0.06967183202505112,
0.07182494550943375,
-0.02569945715367794,
-0.024835238233208656,
0.373623251914978,
0.05177900567650795,
0.14901424944400787,
0.02075118198990822,
0.09358340501785278,
0.043937552720308304,
0.06391450017690659,
-0.08061772584915161,
-0.0482209287583828,
0.14046929776668549,
0.18889781832695007,
0.2525893449783325,
0.05442428216338158,
-0.034017808735370636,
-0.3692838251590729,
-0.06959614157676697,
0.0692671686410904,
-0.10648947954177856,
-0.1016918495297432,
-0.04937517270445824,
-0.17068129777908325,
0.056005921214818954,
-0.05117814615368843,
-0.13817162811756134,
0.009528211317956448,
0.2046375721693039,
0.08975020796060562,
-0.1399797946214676,
-0.17393586039543152,
0.07177776098251343,
-0.07770109921693802,
0.016117701306939125,
-0.05063207074999809,
-0.15926942229270935,
0.19562453031539917,
-0.07166598737239838,
-0.0971168577671051,
-0.1836778074502945,
-0.14948630332946777,
0.02557327225804329,
0.018489385023713112,
0.050024062395095825,
-0.09505695104598999,
0.1275847852230072,
0.0812758356332779,
-0.05510741099715233,
0.18557818233966827,
-0.14951051771640778,
0.2272563874721527,
0.11247748881578445,
0.12697932124137878,
-0.157771036028862,
0.021999387070536613,
-0.05669842287898064,
0.12093249708414078,
-0.03168223425745964,
0.04607486352324486,
0.13418099284172058,
-0.016395725309848785,
0.009831207804381847,
-0.08024858683347702,
-0.02952907606959343,
-0.045488882809877396,
0.146164670586586,
0.07384418696165085,
-0.13282731175422668,
0.25327906012535095,
-0.07976210117340088,
0.22738692164421082,
-0.13373729586601257,
-0.10293490439653397,
0.043862584978342056,
0.09758492559194565,
0.3717106580734253,
0.14159324765205383,
-0.014917373657226562,
-0.058023758232593536,
0.05906682834029198,
-0.14927566051483154,
0.10408658534288406,
-0.08609909564256668,
-0.1035831868648529,
0.04255199059844017,
-0.18134082853794098,
-0.1778508722782135,
-0.17111113667488098,
0.34587910771369934,
0.13091249763965607,
-0.3244777023792267,
-0.049713607877492905,
-0.041939329355955124,
0.026335326954722404,
0.280794233083725,
-0.039605963975191116,
0.15457861125469208,
0.24743208289146423,
0.05618992820382118,
-0.021789174526929855,
0.011202610097825527,
0.15147101879119873,
-0.130799800157547,
0.1354118138551712,
0.07022146880626678,
0.08565552532672882,
0.05471841245889664,
0.0232175774872303,
-0.09127828478813171,
0.22371235489845276,
0.0015764969866722822,
-0.04275685176253319,
-0.14343295991420746,
-0.0665622428059578,
0.09707748144865036,
0.15779897570610046,
-0.222466379404068,
0.22263602912425995,
-0.008058387786149979,
-0.2695034444332123,
-0.4388704001903534,
-0.022065211087465286,
-0.09071790426969528,
0.14441820979118347,
-0.2982169985771179,
-0.09605612605810165,
-0.05182437598705292,
0.07276914268732071,
0.005703588481992483,
0.24595887959003448,
-0.01603345014154911,
0.0964670181274414,
-0.11189025640487671,
0.12524783611297607,
0.10198570787906647,
-0.07506079226732254,
-0.007302881684154272,
0.03785138949751854,
0.1421247124671936,
0.16937115788459778,
-0.0579398013651371,
0.0148554602637887,
0.14020861685276031,
0.03808273747563362,
0.11457885056734085,
-0.06274838745594025,
0.03443209081888199,
0.10548126697540283,
-0.058115363121032715,
0.03536863997578621,
0.10073663294315338,
0.06626366078853607,
0.27730774879455566,
0.021475214511156082,
0.20748673379421234,
-0.055784858763217926,
-0.0023111312184482813,
-0.09514136612415314,
-0.4471742808818817,
-0.16219069063663483,
0.1767336130142212,
0.2352459728717804,
0.06286763399839401,
-0.11881192028522491,
-0.07804157584905624,
0.24320955574512482,
-0.18548861145973206,
-0.09641927480697632,
-0.06568343937397003,
-0.23849964141845703,
-0.1695627123117447,
-0.0839809700846672,
-0.0074103097431361675,
0.026604212820529938,
0.10844475030899048,
-0.11883364617824554,
0.004630713257938623,
-0.24542514979839325,
-0.02902701310813427,
-0.2742049992084503,
-0.06217718496918678,
0.1831079125404358,
-0.07827155292034149,
-0.004411681089550257,
0.05045980587601662,
0.024264266714453697,
0.08280609548091888,
0.1950577348470688,
0.3472253680229187,
-0.09109535813331604,
-0.28740790486335754,
-0.22501133382320404,
-0.09285930544137955,
0.07486347109079361,
-0.053960151970386505,
-0.054705992341041565,
0.13200081884860992,
0.06776436418294907,
0.12445883452892303,
0.061062272638082504,
0.049671873450279236,
0.04107293486595154,
0.030663318932056427,
-0.07596267014741898,
-0.2866114377975464,
0.3429575562477112,
0.21143925189971924,
-0.12636755406856537,
0.11478976905345917,
-0.09290189296007156,
0.09925290942192078,
0.13801603019237518,
0.002721349475905299,
0.2155832201242447,
-0.15338121354579926,
0.08164937049150467,
-0.164385125041008,
0.09221024066209793,
-0.2686019837856293,
-0.03606856241822243,
0.12662182748317719,
-0.03381592035293579,
0.2630804181098938,
0.07503954321146011,
0.10175193101167679,
-0.39081600308418274,
0.07078606635332108,
-0.20034028589725494,
0.04989369586110115,
0.14800168573856354,
-0.03403627127408981,
-0.01722215861082077,
0.06379885971546173,
0.17778363823890686,
0.06568438559770584,
-0.16610807180404663,
-0.00829197745770216,
0.20858456194400787,
0.17098867893218994,
-0.14706037938594818,
-0.20553205907344818,
-0.2801559865474701,
-0.08531012386083603,
-0.04381613805890083,
0.21951216459274292,
0.16365544497966766,
0.11045235395431519,
-0.11971183121204376,
-0.3106863796710968,
-0.09740785509347916,
0.10228603333234787,
0.05341101810336113,
0.25725871324539185,
0.08644907921552658,
-0.15892191231250763,
-0.04460500180721283,
0.12877318263053894,
0.17424987256526947,
-0.11182598024606705,
0.054750386625528336,
0.07782681286334991,
0.11743959039449692,
0.11075007915496826,
-0.23061348497867584,
-0.17618118226528168,
-0.10703640431165695,
-0.2575308382511139,
-0.09064894914627075,
0.20885062217712402,
-0.2112634778022766,
-0.3017333447933197,
0.08942914009094238,
-0.017121920362114906,
0.05599097162485123,
0.08780059963464737,
0.03819427639245987,
0.13191568851470947
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies) is one of several now-distinct entities previously included in the heterogeneous designation of PS . It manifests prenatal asymmetric overgrowth that is primarily proportionate in nature. Affected persons commonly have splayed feet and toes. The vascular malformations are most commonly combined lymphatico-venous anomalies with cutaneous blebbing and weeping. The lipomatous nature of the overgrowth is characterized by overgrowth of fat within normal fatty fascial planes and linear verrucous epidermal nevi. Some persons can have CNS abnormalities. See PIK3CA-Related Segmental Overgrowth.Hemihyperplasia, either as an isolated finding or associated with one of a variety of other manifestations (for review, see Cohen et al ), should be considered. One of the more specific types of hemihyperplasia is the hemihyperplasia with multiple lipomatosis syndrome . This congenital, primarily non-progressive form of hemihyperplasia is sometimes confused with PS. | [
-0.1037360429763794,
-0.023095056414604187,
-0.007200113032013178,
-0.12636058032512665,
0.08809646219015121,
-0.10397311300039291,
-0.0814005434513092,
-0.16376255452632904,
-0.00235597207210958,
0.11049960553646088,
0.13128700852394104,
0.18775354325771332,
-0.04265156388282776,
-0.07942910492420197,
-0.27744734287261963,
0.22847014665603638,
-0.14647036790847778,
-0.07648302614688873,
0.03621329739689827,
-0.17428869009017944,
-0.11152903735637665,
-0.07108698040246964,
-0.08296569436788559,
-0.0725814700126648,
-0.0007846092339605093,
-0.13432039320468903,
0.3240208923816681,
0.2743529975414276,
0.004507291596382856,
-0.057501960545778275,
-0.0879310742020607,
-0.020373119041323662,
-0.1461394727230072,
-0.29856276512145996,
0.12478956580162048,
-0.2930743098258972,
-0.13764941692352295,
0.030024539679288864,
0.1425771266222,
-0.015987630933523178,
-0.09940186142921448,
0.13001970946788788,
-0.1969589740037918,
-0.037494003772735596,
0.2622887194156647,
-0.015086611732840538,
-0.07855979353189468,
0.2142878770828247,
0.06826302409172058,
0.25240370631217957,
0.15349067747592926,
0.1283532679080963,
-0.022603783756494522,
0.02944359928369522,
0.07997280359268188,
-0.222048819065094,
0.08240576833486557,
-0.028719579800963402,
-0.4826635420322418,
-0.006597938947379589,
0.31172922253608704,
0.021336939185857773,
0.23879846930503845,
-0.49891701340675354,
-0.0010300390422344208,
-0.23233678936958313,
-0.13276317715644836,
0.14746302366256714,
0.006461920216679573,
0.13844794034957886,
0.39300984144210815,
-0.19323009252548218,
-0.2315358817577362,
-0.1222430095076561,
-0.0812876746058464,
-0.144628643989563,
0.1603040099143982,
-0.10110978037118912,
-0.13265937566757202,
-0.13545964658260345,
0.06784948706626892,
-0.05740765109658241,
-0.13026443123817444,
0.11632393300533295,
-0.3309668004512787,
-0.16137461364269257,
0.08727312088012695,
-0.05198175087571144,
0.08891431242227554,
0.1162932962179184,
0.07949740439653397,
-0.07652729004621506,
0.050938043743371964,
0.11711334437131882,
0.12042083591222763,
-0.1309925615787506,
0.054472342133522034,
-0.0023531040642410517,
-0.17321300506591797,
0.023638715967535973,
0.12371240556240082,
0.26975902915000916,
0.12765054404735565,
0.04058832302689552,
0.07342968136072159,
-0.1379590481519699,
-0.13888269662857056,
0.08828388154506683,
0.25055789947509766,
-0.002838603686541319,
-0.1849208027124405,
-0.14820532500743866,
-0.1329982876777649,
-0.2037578672170639,
-0.4576880931854248,
-0.26697635650634766,
0.1551879346370697,
-0.045189373195171356,
-0.05393329635262489,
-0.3108167350292206,
0.042903877794742584,
-0.024883972480893135,
0.10234078764915466,
0.012147030793130398,
0.0020172332879155874,
0.13451136648654938,
0.292264461517334,
-0.2597580850124359,
-0.09764596819877625,
-0.1263456642627716,
-0.027078351005911827,
-0.248264878988266,
-0.059197086840867996,
-0.36607077717781067,
0.049419764429330826,
0.1583734154701233,
-0.06110233813524246,
-0.1861279457807541,
0.04823235422372818,
0.10186468064785004,
0.31728148460388184,
0.012201003730297089,
0.24654898047447205,
0.057265087962150574,
0.07907894253730774,
0.05658813193440437,
0.08728288114070892,
0.30588555335998535,
0.18809838593006134,
-0.10960152000188828,
0.42398136854171753,
0.0507388561964035,
0.11830480396747589,
0.13200514018535614,
0.08058474212884903,
-0.06684903055429459,
0.03136339783668518,
0.04709368571639061,
-0.16906143724918365,
-0.00012034435349050909,
-0.1057237759232521,
-0.15943266451358795,
-0.026363881304860115,
-0.1661541610956192,
-0.12696011364459991,
0.17441926896572113,
-0.005798487924039364,
-0.32542648911476135,
0.0500941127538681,
-0.03382226824760437,
-0.2232050597667694,
0.15015798807144165,
-0.11907374858856201,
0.17864039540290833,
-0.06415321677923203,
0.013625556603074074,
0.13277357816696167,
0.16853700578212738,
-0.10705879330635071,
0.22524072229862213,
0.1842246949672699,
-0.0340643934905529,
-0.08387020975351334,
-0.1812848597764969,
-0.06472201645374298,
-0.08326166123151779,
0.00774399284273386,
0.1614466905593872,
-0.20441289246082306,
-0.037771522998809814,
0.24828504025936127,
-0.01577385701239109,
-0.05052042379975319,
-0.032871171832084656,
-0.03388433903455734,
-0.31083405017852783,
-0.051955197006464005,
-0.009686394594609737,
0.18885232508182526,
0.1171129122376442,
0.13436205685138702,
0.06433191150426865,
0.20154766738414764,
0.04464706405997276,
0.2564823031425476,
0.002074739197269082,
0.08779019117355347,
-0.15241307020187378,
-0.00407788809388876,
0.1432739794254303,
0.00701157609000802,
0.33382412791252136,
-0.11190348118543625,
-0.10847552865743637,
0.04423433169722557,
-0.07870514690876007,
-0.25995537638664246,
-0.1043468788266182,
-0.03284922242164612,
0.17069029808044434,
-0.17288252711296082,
0.1676366925239563,
-0.032900337129831314,
-0.11057854443788528,
-0.2514050006866455,
0.17450878024101257,
0.02885623276233673,
0.0004386977816466242,
0.1166641041636467,
0.15168552100658417,
-0.1840508133172989,
0.009595313109457493,
0.12239140272140503,
0.2412337362766266,
0.0010808586375787854,
-0.2958877682685852,
-0.20445887744426727,
0.17779095470905304,
-0.007804109249264002,
0.2519834339618683,
-0.08963026851415634,
-0.0927169993519783,
0.014884382486343384,
-0.13007581233978271,
-0.19769607484340668,
0.22128446400165558,
-0.011037870310246944,
-0.07457292824983597,
-0.05952870473265648,
0.03733961284160614,
0.08764800429344177,
-0.21601898968219757,
0.19817690551280975,
0.1840640902519226,
-0.14124423265457153,
-0.07860806584358215,
0.03890455886721611,
0.09403465688228607,
0.050252459943294525,
0.035694532096385956,
0.29308968782424927,
0.1430988311767578,
0.2976610064506531,
-0.03907187283039093,
-0.28187432885169983,
-0.20063088834285736,
0.01211526244878769,
0.150858536362648,
0.11323712021112442,
-0.2802830636501312,
-0.05524645745754242,
0.2618016004562378,
0.10477086156606674,
-0.023556318134069443,
0.13413631916046143,
0.20542629063129425,
0.09846150875091553,
-0.01458800584077835,
0.16545340418815613,
0.09485577791929245,
0.05198802798986435,
-0.0586576834321022,
-0.046450063586235046,
-0.026697542518377304,
0.23125381767749786,
0.06442710757255554,
-0.42567530274391174,
0.2617088258266449,
0.0633595660328865,
-0.18989194929599762,
0.03748173639178276,
-0.022314798086881638,
0.16634045541286469,
-0.07376596331596375,
0.02861487865447998,
0.2608078122138977,
-0.11253137141466141,
-0.04234422370791435,
0.19652770459651947,
-0.16790364682674408,
0.0722651556134224,
0.02735975570976734,
-0.11386390030384064,
0.07569941878318787,
0.09163860231637955,
-0.06812164187431335,
0.18991507589817047,
-0.05325639620423317,
-0.04903460294008255,
-0.14676275849342346,
-0.14292463660240173,
0.1625952422618866,
0.08570948988199234,
0.11475427448749542,
-0.028864676132798195,
-0.057400669902563095,
-0.10395625978708267,
0.08013579249382019,
0.29795312881469727,
-0.1212824285030365,
0.0054753730073571205,
-0.01516930852085352,
0.18341068923473358,
0.1368483006954193,
0.03758978843688965,
-0.04441297799348831,
0.12829847633838654,
0.2401462346315384,
-0.12555143237113953,
0.16175201535224915,
0.11396833509206772,
0.12652696669101715,
-0.07201940566301346,
-0.13659504055976868,
0.024775588884949684,
0.04058796167373657,
-0.05658666044473648,
-0.11715928465127945,
0.06316156685352325,
0.0208403579890728,
-0.029952939599752426,
-0.3082803785800934,
-0.026169857010245323,
-0.04777447506785393,
0.029008183628320694,
-0.021756011992692947,
0.03402305021882057,
0.21986901760101318,
-0.004581547807902098,
-0.10533661395311356,
-0.0177628044039011,
-0.06522754579782486,
-0.16345421969890594,
-0.24440230429172516,
0.05019676312804222,
0.07159269601106644,
0.08012592792510986,
0.16578470170497894,
-0.03820410743355751,
0.08770125359296799,
-0.1500052660703659,
-0.06578084826469421,
-0.13523806631565094,
0.006235530599951744,
-0.1470782607793808,
-0.043368007987737656,
-0.37149134278297424,
0.027195516973733902,
0.17517727613449097,
-0.08734511584043503,
0.372260183095932,
0.12147027254104614,
0.04903349280357361,
-0.10601659119129181,
0.07797395437955856,
0.10644929111003876,
-0.1981758028268814,
-0.04461072012782097,
-0.15630508959293365,
-0.20306862890720367,
-0.19651763141155243,
0.05665032938122749,
0.34596145153045654,
-0.18273214995861053,
-0.11345187574625015,
0.051490411162376404,
-0.3563934564590454,
0.15787674486637115,
-0.00205079629085958,
-0.1300302892923355,
0.1862632781267166,
0.018405331298708916,
-0.1007300615310669,
0.24733227491378784,
-0.029067929834127426,
-0.04124750196933746,
0.11177769303321838,
-0.18045446276664734,
-0.28552958369255066,
-0.09562046080827713,
-0.0868731290102005,
-0.02068333514034748,
0.08328685909509659,
0.206867054104805,
0.2232634574174881,
0.06986338645219803,
-0.13487714529037476,
0.16151568293571472,
-0.04947132244706154,
0.3758164942264557,
-0.25949788093566895,
-0.08911485224962234,
0.017823539674282074,
-0.051639750599861145,
-0.08208265155553818,
-0.19248098134994507,
0.03450645133852959,
-0.06735434383153915,
0.16923262178897858,
-0.19404453039169312,
0.15114092826843262,
-0.2750869393348694,
0.07032465189695358,
-0.0400824211537838,
-0.13282552361488342,
0.05447142571210861,
-0.0561797134578228,
-0.08014271408319473,
-0.11001498997211456,
0.14012710750102997,
0.22179535031318665,
0.010620854794979095,
-0.2659791111946106,
0.08405692130327225,
0.10880360007286072,
0.30223748087882996,
0.021977124735713005,
0.11721110343933105,
0.2082432061433792,
0.04213623329997063,
0.2357451319694519,
0.17890262603759766,
0.13474538922309875,
0.11164549738168716,
0.10699359327554703,
0.1392941176891327,
-0.08117164671421051,
0.21987022459506989,
-0.06581257283687592,
0.05199754983186722,
-0.0074532534927129745,
0.147469624876976,
0.11340083181858063,
0.011408246122300625,
0.18911468982696533,
0.15028928220272064,
-0.020138463005423546,
0.028367720544338226,
-0.14274612069129944,
0.14904271066188812,
0.0070128059014678,
0.16994081437587738,
0.2650894224643707,
0.03055175393819809,
0.027641985565423965,
0.10678578913211823,
-0.41581761837005615,
0.06174960732460022,
0.26160112023353577,
0.035765066742897034,
0.03613460436463356,
0.04239225760102272,
0.1776513159275055,
-0.09008149802684784,
0.06737145036458969,
0.09511913359165192,
0.09974271804094315,
0.0461292527616024,
-0.23261658847332,
0.2317986637353897,
0.13655254244804382,
0.06537812203168869,
0.015713995322585106,
-0.07133560627698898,
0.0709787905216217,
0.17571182548999786,
-0.017709294334053993,
-0.09193399548530579,
0.2789970636367798,
-0.06618858873844147,
0.19362418353557587,
0.12054436653852463,
0.0008788640843704343,
0.5690585970878601,
0.05850578472018242,
0.05811963975429535,
0.10375058650970459,
0.08208518475294113,
0.0025019189342856407,
-0.10220373421907425,
-0.020847784355282784,
0.006284849718213081,
0.005633654538542032,
0.09315337985754013,
0.02183486707508564,
0.017700377851724625,
-0.025376908481121063,
-0.30439499020576477,
-0.1496252417564392,
0.07545102387666702,
-0.12649525701999664,
-0.118731789290905,
0.03230307623744011,
-0.19471147656440735,
0.06752093881368637,
0.036025773733854294,
-0.08547668904066086,
0.14337868988513947,
0.1252787709236145,
-0.053272001445293427,
-0.16835151612758636,
-0.06179829314351082,
0.18831884860992432,
0.041466958820819855,
-0.01022595539689064,
-0.09787905216217041,
-0.12072070688009262,
0.15103137493133545,
-0.06534769386053085,
-0.0043396856635808945,
-0.3136902153491974,
-0.039288103580474854,
0.06711685657501221,
-0.05440264567732811,
0.032721925526857376,
-0.0924064964056015,
0.15693625807762146,
-0.06814564764499664,
0.03558892384171486,
0.2828858196735382,
-0.15031743049621582,
0.3599853515625,
0.043034475296735764,
0.07664722949266434,
-0.05629998445510864,
-0.10933534055948257,
0.0476946085691452,
0.16107621788978577,
0.001202161074616015,
0.2514435350894928,
0.15511690080165863,
-0.06923884898424149,
0.059839021414518356,
-0.07081476598978043,
-0.09499179571866989,
0.08171830326318741,
0.07839887589216232,
0.09038887917995453,
-0.09541033208370209,
0.28719180822372437,
-0.060363031923770905,
0.19018389284610748,
0.026043547317385674,
0.027898015454411507,
0.09015137702226639,
0.14806926250457764,
0.3834760785102844,
0.17056049406528473,
-0.05458178371191025,
0.07694212347269058,
-0.04303959012031555,
-0.13248707354068756,
0.17472606897354126,
-0.13153806328773499,
-0.04611990600824356,
-0.03943166881799698,
-0.05483989417552948,
-0.21092645823955536,
-0.25424739718437195,
0.25175994634628296,
0.19996415078639984,
-0.24030351638793945,
-0.0586821585893631,
-0.1391472965478897,
0.06803222745656967,
0.1847420483827591,
-0.2056681364774704,
0.17540428042411804,
0.383806437253952,
0.03201901167631149,
-0.02344409003853798,
-0.14274710416793823,
0.1755688339471817,
-0.06418686360120773,
0.0315810889005661,
0.07214529067277908,
0.26101282238960266,
0.030684465542435646,
-0.030004186555743217,
-0.005328659899532795,
0.13418644666671753,
-0.10717523843050003,
-0.10743489861488342,
-0.19714979827404022,
-0.15046462416648865,
0.02199210785329342,
0.038970328867435455,
-0.2202029973268509,
0.287354975938797,
0.04737776145339012,
-0.28565144538879395,
-0.29893550276756287,
-0.02660718373954296,
-0.08733515441417694,
0.10212317854166031,
-0.32215777039527893,
0.02341107651591301,
-0.007536138873547316,
0.13898734748363495,
0.11781994998455048,
0.40714967250823975,
0.030865684151649475,
0.06895142793655396,
-0.20442454516887665,
0.042603570967912674,
0.1921980082988739,
-0.07227896898984909,
-0.04870934411883354,
0.15132363140583038,
0.10720500349998474,
0.09518377482891083,
-0.06216270104050636,
-0.022413823753595352,
0.040157750248909,
0.04029020294547081,
0.17158891260623932,
0.06675467640161514,
-0.0513136200606823,
-0.019919157028198242,
-0.15515929460525513,
0.05071306228637695,
0.055853571742773056,
0.07088795304298401,
0.37221264839172363,
-0.21611681580543518,
0.24379867315292358,
0.015056529082357883,
-0.12832413613796234,
-0.25619444251060486,
-0.4028359055519104,
-0.19728465378284454,
0.18422731757164001,
0.09725330770015717,
0.0882720798254013,
0.013230858370661736,
0.02404364012181759,
0.1245308443903923,
-0.008341292850673199,
-0.06915688514709473,
0.02059619314968586,
-0.21641424298286438,
0.00696839764714241,
-0.10890411585569382,
0.0255380067974329,
0.10582036525011063,
0.08961191773414612,
-0.07425522059202194,
0.11587445437908173,
-0.25807899236679077,
-0.1334526538848877,
-0.39001402258872986,
0.11974753439426422,
0.1584370732307434,
0.0069531346671283245,
0.07619284838438034,
0.07097592204809189,
0.13612864911556244,
-0.24763457477092743,
0.16705693304538727,
0.3891729712486267,
-0.053261347115039825,
-0.31694719195365906,
-0.1250256896018982,
-0.2519817650318146,
0.010868895798921585,
-0.0007273583905771375,
-0.13219305872917175,
-0.009647988714277744,
0.24291501939296722,
0.038304660469293594,
0.12726794183254242,
-0.027834566310048103,
-0.010580135509371758,
-0.1273639053106308,
-0.05045642331242561,
-0.37547168135643005,
0.3929172158241272,
0.05463976785540581,
-0.06649250537157059,
0.01848437264561653,
-0.19486334919929504,
0.05901295319199562,
0.03003072552382946,
-0.03497469425201416,
0.2683422863483429,
-0.11619788408279419,
0.0904918983578682,
-0.2589958608150482,
0.027281785383820534,
-0.30388373136520386,
0.06294190883636475,
0.15043073892593384,
-0.13958941400051117,
0.1875467151403427,
-0.00562659977003932,
0.16000500321388245,
-0.2920381724834442,
-0.023014811798930168,
-0.20282433927059174,
0.002730913693085313,
0.09170684218406677,
-0.06375743448734283,
0.07857290655374527,
-0.03366163372993469,
0.1505531519651413,
-0.008908664807677269,
-0.1328808218240738,
-0.0821303203701973,
0.1709703505039215,
0.14001847803592682,
-0.13991400599479675,
-0.23932814598083496,
-0.265142560005188,
-0.07125115394592285,
-0.04251642897725105,
0.10258400440216064,
0.046521738171577454,
0.08299562335014343,
-0.11347272992134094,
-0.3112393915653229,
-0.041454993188381195,
0.05642740800976753,
-0.031975775957107544,
0.2290576994419098,
0.12885728478431702,
-0.22410398721694946,
0.16369156539440155,
0.07805059850215912,
0.16501672565937042,
-0.11792775988578796,
-0.050786715000867844,
0.02723143808543682,
0.15590104460716248,
0.12048517912626266,
-0.11267665028572083,
-0.23801016807556152,
-0.16316969692707062,
-0.19043485820293427,
-0.11377696692943573,
0.1459738165140152,
-0.17118988931179047,
-0.3653448820114136,
0.01121536735445261,
0.017071031033992767,
-0.10300874710083008,
0.19656990468502045,
0.019883397966623306,
0.11888787895441055
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. fascial planes and linear verrucous epidermal nevi. Some persons can have CNS abnormalities. See PIK3CA-Related Segmental Overgrowth.Hemihyperplasia, either as an isolated finding or associated with one of a variety of other manifestations (for review, see Cohen et al ), should be considered. One of the more specific types of hemihyperplasia is the hemihyperplasia with multiple lipomatosis syndrome . This congenital, primarily non-progressive form of hemihyperplasia is sometimes confused with PS.Klippel-Trenaunay syndrome is a disorder that manifests both overgrowth and vascular malformations. However, in this disorder the overgrowth is generally ipsilateral and overlapping with the vascular malformations, the typical vascular malformation is the lateral venous anomaly, and the skeletal overgrowth is entirely lacking in the distortion and progressivity seen in persons with PS .ManagementEvaluations Following Initial DiagnosisTo establish the extent of disease in an individual diagnosed with Proteus syndrome (PS), the following evaluations are recommended if | [
-0.18384934961795807,
-0.04651501029729843,
-0.02732918970286846,
-0.1797397881746292,
0.1028057411313057,
-0.018314290791749954,
-0.051294710487127304,
-0.11462666094303131,
-0.05378251150250435,
0.16426563262939453,
0.16764630377292633,
0.12664306163787842,
-0.07031159847974777,
-0.09648126363754272,
-0.29271766543388367,
0.2731364071369171,
-0.2006458193063736,
-0.041063301265239716,
0.07453712075948715,
-0.002993304980918765,
-0.06665574014186859,
-0.12396711111068726,
0.016859235242009163,
-0.05032345652580261,
-0.013985441997647285,
-0.2557074725627899,
0.25879809260368347,
0.2804712951183319,
-0.021754372864961624,
0.015947410836815834,
-0.037572942674160004,
-0.04322240501642227,
-0.11332987993955612,
-0.49887514114379883,
-0.00387436430901289,
-0.28785833716392517,
-0.31212037801742554,
0.023593507707118988,
0.2408553659915924,
-0.09528736025094986,
-0.031505972146987915,
0.16788451373577118,
-0.19869160652160645,
-0.10015123337507248,
0.2510948181152344,
-0.06502452492713928,
-0.05551048740744591,
0.20890766382217407,
0.031174542382359505,
0.2178596556186676,
0.17352180182933807,
0.041635945439338684,
0.1242767944931984,
-0.016470303758978844,
0.13458524644374847,
-0.06271582841873169,
-0.06373495608568192,
-0.09671394526958466,
-0.5189952254295349,
-0.031183477491140366,
0.24824441969394684,
-0.018604576587677002,
0.21357442438602448,
-0.436038613319397,
-0.030254840850830078,
-0.1757580190896988,
-0.05841605365276337,
0.05335836485028267,
0.09122075140476227,
0.10927316546440125,
0.3693807125091553,
-0.17834876477718353,
-0.15870800614356995,
-0.036474164575338364,
-0.03301836550235748,
-0.1566448211669922,
0.10354345291852951,
-0.12528438866138458,
-0.03911980614066124,
-0.2342994511127472,
0.0499291718006134,
-0.05362239107489586,
-0.09871354699134827,
0.1282990425825119,
-0.2737310230731964,
-0.1388435810804367,
0.03935529291629791,
-0.05819889158010483,
-0.004865824244916439,
0.04949718713760376,
0.10617142915725708,
0.013072183355689049,
-0.031447067856788635,
0.1453990638256073,
0.06855019181966782,
-0.1336784064769745,
-0.05941068381071091,
-0.03233017399907112,
-0.1430792659521103,
-0.00043987378012388945,
0.23402966558933258,
0.21602080762386322,
0.05475304648280144,
-0.03395715728402138,
0.05738426744937897,
-0.0912695899605751,
-0.1456092894077301,
0.027180811390280724,
0.2610989809036255,
-0.03444285690784454,
-0.09626966714859009,
-0.08918101340532303,
-0.03474166616797447,
-0.21708358824253082,
-0.4083383083343506,
-0.26332029700279236,
0.1566542387008667,
-0.0986282080411911,
0.019045984372496605,
-0.2571439743041992,
0.005094070918858051,
-0.036381594836711884,
0.06762577593326569,
0.022905848920345306,
0.0295019019395113,
0.008786867372691631,
0.25009602308273315,
-0.23041284084320068,
-0.023611318320035934,
-0.13529911637306213,
0.03377632796764374,
-0.2180698961019516,
-0.07729889452457428,
-0.19779673218727112,
-0.03204039856791496,
0.15214940905570984,
0.0018032488878816366,
-0.1493557244539261,
0.10393330454826355,
0.009986182674765587,
0.31851571798324585,
0.05978595092892647,
0.29153427481651306,
0.05898977443575859,
-0.005473024677485228,
0.07267121970653534,
0.18550176918506622,
0.09721080958843231,
0.15980574488639832,
-0.13479174673557281,
0.36675310134887695,
-0.05044309422373772,
0.1989888846874237,
0.08557736873626709,
0.060037076473236084,
0.022548949345946312,
0.04320326820015907,
0.07942099869251251,
-0.059561580419540405,
0.01047444436699152,
-0.023313913494348526,
-0.11756987869739532,
-0.014647345058619976,
-0.10968442261219025,
-0.10277807712554932,
0.15302598476409912,
0.017575962468981743,
-0.22726702690124512,
0.01947670429944992,
-0.05429277569055557,
-0.07953713089227676,
0.08728937804698944,
-0.15328727662563324,
0.046292465180158615,
-0.07361066341400146,
-0.08578365296125412,
0.115419901907444,
0.17893996834754944,
-0.0847771167755127,
0.23055371642112732,
0.030316324904561043,
-0.03341050446033478,
0.03195223584771156,
-0.1579235941171646,
-0.09291724860668182,
-0.13964694738388062,
0.0515761636197567,
0.11836884170770645,
-0.25739461183547974,
-0.007053588051348925,
0.16777078807353973,
-0.04873694106936455,
-0.08960799127817154,
-0.02306622453033924,
-0.009474853053689003,
-0.20841538906097412,
-0.05802871286869049,
-0.040710460394620895,
0.09202846139669418,
0.04991970583796501,
0.08930234611034393,
0.05469050630927086,
0.11391881108283997,
0.0318676233291626,
0.134443461894989,
0.03301089257001877,
0.0663810595870018,
-0.09356192499399185,
0.056869201362133026,
0.036861591041088104,
-0.03876879811286926,
0.35691162943840027,
-0.16289809346199036,
-0.02015530876815319,
0.03229747712612152,
0.048837486654520035,
-0.20023663341999054,
-0.14973507821559906,
-0.018663164228200912,
0.1773783266544342,
-0.22397969663143158,
0.1411234736442566,
-0.04778333008289337,
-0.21191231906414032,
-0.3485103249549866,
0.15715761482715607,
0.011012009344995022,
-0.0766649916768074,
0.03254209831357002,
0.09061353653669357,
-0.1550796627998352,
0.014039665460586548,
-0.01195254735648632,
0.1711282879114151,
0.03595142066478729,
-0.13705678284168243,
-0.18086743354797363,
0.24510979652404785,
-0.026148183271288872,
0.18461273610591888,
-0.06773937493562698,
0.06039319559931755,
0.02148641273379326,
-0.13500842452049255,
-0.1789010465145111,
0.14285293221473694,
0.07067133486270905,
-0.05681316554546356,
-0.08912475407123566,
0.02171489968895912,
0.17588554322719574,
-0.17427261173725128,
0.17455224692821503,
0.1123315840959549,
-0.1918603479862213,
-0.06897161900997162,
0.10710397362709045,
0.003236647229641676,
0.07244925945997238,
0.015553192235529423,
0.21613864600658417,
0.14855851233005524,
0.2158930003643036,
-0.007774556986987591,
-0.2523268759250641,
-0.10902144014835358,
-0.046626556664705276,
0.28042012453079224,
0.027339207008481026,
-0.2708955705165863,
-0.12204616516828537,
0.2632019519805908,
0.10479623079299927,
0.002474058885127306,
0.06406023353338242,
0.12621860206127167,
0.0555635541677475,
0.10142523050308228,
0.17255565524101257,
0.12001796066761017,
0.1130763366818428,
-0.04584944620728493,
0.03238336369395256,
-0.02297085151076317,
0.28936487436294556,
-0.007624517194926739,
-0.34667134284973145,
0.1887974590063095,
0.004365338943898678,
-0.1784142255783081,
0.0015202612848952413,
0.01620873063802719,
0.019416533410549164,
-0.0840262919664383,
0.08896169066429138,
0.29668259620666504,
-0.08381427824497223,
-0.020061763003468513,
0.14971379935741425,
-0.06304798275232315,
0.04902249202132225,
0.19228726625442505,
-0.1545708030462265,
0.0174422487616539,
0.042220693081617355,
-0.018248701468110085,
0.22183147072792053,
-0.054953090846538544,
0.039975836873054504,
-0.08687467128038406,
-0.1080269068479538,
0.1800793707370758,
0.13358716666698456,
0.08022776246070862,
-0.12184575945138931,
-0.05164898931980133,
-0.20895783603191376,
0.010319801978766918,
0.23196879029273987,
-0.1238882765173912,
-0.0392182357609272,
-0.05012960359454155,
-0.003196253441274166,
0.09670430421829224,
0.14948906004428864,
-0.07719378918409348,
0.03183737024664879,
0.2430531233549118,
-0.043292585760354996,
0.06311596930027008,
0.02248452417552471,
0.11169645190238953,
-0.07533441483974457,
-0.17138026654720306,
0.0927290990948677,
0.09102344512939453,
0.00786151085048914,
-0.10253569483757019,
0.025607634335756302,
0.04236951842904091,
-0.10205072909593582,
-0.3575916588306427,
0.01736830361187458,
-0.07346603274345398,
0.04649651423096657,
0.010843981057405472,
-0.003286742838099599,
0.05292303115129471,
-0.010790057480335236,
-0.12679052352905273,
-0.002773784566670656,
-0.2595289945602417,
-0.0974702388048172,
-0.2515377402305603,
-0.0033263578079640865,
0.12384017556905746,
0.13544802367687225,
0.08598075062036514,
-0.05418584495782852,
0.06309530884027481,
-0.1608363389968872,
-0.11858686804771423,
-0.17955929040908813,
-0.040821440517902374,
-0.10902748256921768,
-0.01622532121837139,
-0.2985614240169525,
0.014818396419286728,
0.23615267872810364,
-0.09955943375825882,
0.363496333360672,
0.09499267488718033,
-0.0012089075753465295,
-0.18563148379325867,
-0.002824128372594714,
0.11245889961719513,
-0.16951796412467957,
-0.04373554140329361,
-0.1691930890083313,
-0.18263010680675507,
-0.0445425845682621,
0.047424428164958954,
0.38414591550827026,
-0.16025058925151825,
-0.06919427216053009,
-0.0473090223968029,
-0.34711694717407227,
0.21151630580425262,
0.06922920048236847,
-0.18773211538791656,
0.14580777287483215,
0.0553218275308609,
-0.07628127187490463,
0.16672129929065704,
-0.043809786438941956,
-0.030517255887389183,
0.14861902594566345,
-0.09399420022964478,
-0.3306630849838257,
-0.04467165470123291,
0.024898983538150787,
-0.03509317710995674,
0.10418696701526642,
0.2205214500427246,
0.21215605735778809,
-0.0022484257351607084,
-0.13110870122909546,
0.0584280900657177,
-0.056922797113657,
0.38433367013931274,
-0.2285347580909729,
-0.0630895346403122,
0.02966414950788021,
-0.060647182166576385,
-0.10913653671741486,
-0.26059967279434204,
0.06560223549604416,
-0.023869508877396584,
0.1484355628490448,
-0.1584213674068451,
0.10587814450263977,
-0.2987138628959656,
0.07117129117250443,
-0.0847952663898468,
-0.1245451420545578,
0.020175792276859283,
-0.022094376385211945,
-0.013585020788013935,
-0.16253545880317688,
0.19018211960792542,
0.42496466636657715,
-0.0652901753783226,
-0.25823140144348145,
-0.020453328266739845,
0.09908066689968109,
0.22291958332061768,
0.0004983745166100562,
0.09144463390111923,
0.1418699026107788,
0.023630855605006218,
0.32796579599380493,
0.144588440656662,
0.15218988060951233,
0.08401782810688019,
0.016238702461123466,
0.04405795410275459,
-0.04007083922624588,
0.18411576747894287,
-0.09378083050251007,
0.04334660619497299,
-0.040383875370025635,
0.09141595661640167,
0.19155798852443695,
0.024357736110687256,
0.11285658925771713,
0.22752702236175537,
0.03216962143778801,
0.07539786398410797,
-0.08852050453424454,
0.17807453870773315,
0.00901635829359293,
0.1359090358018875,
0.26693060994148254,
-0.019806550815701485,
0.052527207881212234,
0.11269409954547882,
-0.2991577982902527,
0.08446689695119858,
0.16430561244487762,
0.07410342991352081,
0.03356565535068512,
0.016788601875305176,
0.17471249401569366,
-0.03334827348589897,
0.004421948455274105,
0.04482663422822952,
-0.06113579869270325,
0.004817691631615162,
-0.20942063629627228,
0.10933560878038406,
0.26401418447494507,
0.0979827493429184,
0.034251630306243896,
-0.1259187012910843,
0.11503125727176666,
0.20980262756347656,
0.07381852716207504,
-0.16869254410266876,
0.3279896676540375,
-0.10852839797735214,
0.17650894820690155,
0.04867037385702133,
0.007271553389728069,
0.3338792622089386,
0.07936215400695801,
0.08411851525306702,
0.2173258513212204,
0.1589687168598175,
-0.013883068226277828,
-0.16802042722702026,
-0.05602242052555084,
-0.022466782480478287,
0.03258753940463066,
0.039155103266239166,
0.11075786501169205,
0.09549273550510406,
-0.07759932428598404,
-0.32415398955345154,
-0.06655741482973099,
0.04588506370782852,
-0.07143182307481766,
-0.0688624158501625,
0.021425776183605194,
-0.2723771333694458,
0.0029884097166359425,
-0.0314563512802124,
-0.05104459822177887,
0.11118932068347931,
0.16391046345233917,
0.023709822446107864,
-0.06208889186382294,
-0.03632057085633278,
0.07287042587995529,
0.011676175519824028,
-0.08077946305274963,
-0.10242536664009094,
-0.15833145380020142,
0.1939021795988083,
-0.013017231598496437,
0.010838311165571213,
-0.2082245647907257,
-0.018172547221183777,
0.060932423919439316,
-0.1148185208439827,
0.12218349426984787,
-0.10216370224952698,
0.1101752296090126,
-0.07738634943962097,
0.005610913969576359,
0.33438360691070557,
-0.13453175127506256,
0.16244423389434814,
0.10462179780006409,
0.1030760407447815,
-0.11141958087682724,
-0.010084759443998337,
0.11364562809467316,
0.06974118947982788,
0.019809497520327568,
0.2664930820465088,
0.08940022438764572,
-0.024384446442127228,
0.020143069326877594,
-0.11539745330810547,
0.040983039885759354,
-0.030488476157188416,
0.16373354196548462,
0.1300135850906372,
-0.07492642104625702,
0.29903194308280945,
-0.1232185885310173,
0.08554491400718689,
0.07326740026473999,
-0.03431573882699013,
0.06859924644231796,
0.17291606962680817,
0.3287295997142792,
0.08639520406723022,
-0.022343501448631287,
0.07140374928712845,
-0.0035499173682183027,
-0.11604282259941101,
0.1965615600347519,
-0.23052088916301727,
0.004137061070650816,
0.04321743920445442,
-0.09507407993078232,
-0.14694219827651978,
-0.24110263586044312,
0.15563054382801056,
0.18351490795612335,
-0.24081425368785858,
-0.07728726416826248,
-0.16796642541885376,
0.012498772703111172,
0.254717081785202,
-0.1815088838338852,
0.21646633744239807,
0.4166313707828522,
0.11518453061580658,
-0.16342782974243164,
-0.193192258477211,
0.06622982770204544,
-0.062065139412879944,
0.0032777469605207443,
-0.003926774952560663,
0.19283874332904816,
-0.073475182056427,
-0.026877781376242638,
0.0017075225478038192,
0.08546622097492218,
-0.0015909725334495306,
-0.12649817764759064,
-0.19919690489768982,
-0.1537635773420334,
-0.001208099303767085,
0.036789607256650925,
-0.18901371955871582,
0.27182358503341675,
0.05786464363336563,
-0.28376397490501404,
-0.3468470573425293,
0.06902924180030823,
-0.08781907707452774,
0.1679360270500183,
-0.2046579122543335,
0.025048427283763885,
-0.040690939873456955,
0.11947594583034515,
0.06906608492136002,
0.35616546869277954,
0.025005517527461052,
0.12658599019050598,
-0.10889129340648651,
-0.03485602140426636,
0.16439500451087952,
-0.02581183798611164,
-0.045706018805503845,
0.13768523931503296,
0.0531204454600811,
0.07321245223283768,
-0.06893976777791977,
-0.05913478881120682,
0.054441582411527634,
0.03526744246482849,
0.14485493302345276,
-0.012369762174785137,
-0.0809582844376564,
0.030819572508335114,
-0.18418386578559875,
-0.02849605120718479,
0.049898725003004074,
0.04491697624325752,
0.19762173295021057,
-0.1638130247592926,
0.24046728014945984,
0.030136290937662125,
0.005913940258324146,
-0.2179347574710846,
-0.34411099553108215,
-0.09027718752622604,
0.07427927106618881,
0.19077472388744354,
0.16447219252586365,
0.02520449459552765,
0.007910419255495071,
0.13483330607414246,
-0.055329617112874985,
-0.05014987662434578,
0.09745264798402786,
-0.19411978125572205,
0.023552382364869118,
-0.13930605351924896,
-0.06960484385490417,
0.13377107679843903,
0.15739434957504272,
0.07797577232122421,
0.06325633078813553,
-0.26715219020843506,
-0.1706293374300003,
-0.2952175736427307,
0.1819746345281601,
0.15187709033489227,
0.05894258990883827,
0.06026516482234001,
0.04262091591954231,
0.13388879597187042,
-0.10706710070371628,
0.19994671642780304,
0.37806013226509094,
-0.10229115188121796,
-0.2712552547454834,
-0.08001407980918884,
-0.13698306679725647,
0.036936212331056595,
-0.061712298542261124,
-0.11809277534484863,
0.002161748241633177,
0.2319563776254654,
0.020433038473129272,
0.05314936116337776,
0.0665980651974678,
-0.04860994219779968,
-0.1268298476934433,
-0.06284180283546448,
-0.3163348138332367,
0.35686177015304565,
0.0061766779981553555,
-0.11578945070505142,
-0.009690985083580017,
-0.09433915466070175,
-0.008988884277641773,
0.07047318667173386,
0.14202113449573517,
0.20081880688667297,
-0.19092917442321777,
0.1130230650305748,
-0.3287867605686188,
-0.05254168063402176,
-0.25543081760406494,
0.07811573892831802,
0.04238321632146835,
-0.09932899475097656,
0.10471837222576141,
0.12299884855747223,
0.15732187032699585,
-0.21453948318958282,
-0.055780861526727676,
-0.1731380820274353,
0.0632176548242569,
0.08963573724031448,
-0.0802532210946083,
-0.05615270137786865,
-0.01473380159586668,
0.20280592143535614,
-0.0009415417443960905,
-0.11627695709466934,
-0.04976450279355049,
0.1246897354722023,
0.023830335587263107,
-0.21419762074947357,
-0.16237567365169525,
-0.2090011090040207,
0.04629107937216759,
0.13883429765701294,
0.1035458967089653,
0.11564266681671143,
0.01657756231725216,
-0.19278910756111145,
-0.1937713474035263,
-0.029125304892659187,
0.022173898294568062,
-0.039259955286979675,
0.15120625495910645,
0.12663982808589935,
-0.21378396451473236,
0.05867135524749756,
0.02714367024600506,
0.1709848940372467,
-0.1683458387851715,
-0.06166498735547066,
0.050740797072649,
-0.026620380580425262,
0.03746304661035538,
-0.21423864364624023,
-0.1654222160577774,
-0.20525814592838287,
-0.15236148238182068,
-0.07828916609287262,
0.19273598492145538,
-0.1568719893693924,
-0.3009428083896637,
0.045844174921512604,
0.044384364038705826,
-0.11183679103851318,
0.13532714545726776,
0.0551149919629097,
0.1523030549287796
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. sometimes confused with PS.Klippel-Trenaunay syndrome is a disorder that manifests both overgrowth and vascular malformations. However, in this disorder the overgrowth is generally ipsilateral and overlapping with the vascular malformations, the typical vascular malformation is the lateral venous anomaly, and the skeletal overgrowth is entirely lacking in the distortion and progressivity seen in persons with PS .ManagementEvaluations Following Initial DiagnosisTo establish the extent of disease in an individual diagnosed with Proteus syndrome (PS), the following evaluations are recommended if they have not already been completed :Detailed and comprehensive (general, spine, and hand) orthopedic evaluationSkeletal survey as a baseline study of the extent and severity of overgrowthCT examination, possibly with three-dimensional reconstruction for individuals with significant scoliosis. As the vertebral bodies are commonly progressively deformed, this study can be very helpful for surgical planning.Pulmonology consultation, pulmonary function testing, and high-resolution CT examination of the chest for individuals with signs or symptoms suggestive of bullous pulmonary disease | [
-0.16933183372020721,
-0.0039655715227127075,
-0.00618607085198164,
-0.3161811828613281,
0.06799088418483734,
-0.003997922409325838,
0.03746321424841881,
-0.09304078668355942,
-0.06212044879794121,
0.1068907380104065,
0.04982779175043106,
0.23377075791358948,
-0.010237486101686954,
-0.021005110815167427,
-0.3068348467350006,
0.3238081932067871,
-0.03740203008055687,
-0.10506363213062286,
0.06602181494235992,
0.11997030675411224,
-0.07575952261686325,
-0.06660504639148712,
0.04350552335381508,
0.0037710079923272133,
-0.00801964569836855,
-0.14666415750980377,
0.17538981139659882,
0.19228290021419525,
0.04483240842819214,
-0.05077872425317764,
-0.08122949302196503,
-0.15627539157867432,
-0.12619608640670776,
-0.5064926147460938,
-0.0689016655087471,
-0.28334999084472656,
-0.2873038947582245,
-0.012646529823541641,
0.1705489456653595,
-0.07382139563560486,
-0.0873170867562294,
0.11158379912376404,
-0.08181676268577576,
-0.043131809681653976,
0.20740507543087006,
-0.022414090111851692,
-0.017427170649170876,
0.20711162686347961,
-0.004669101908802986,
0.18228410184383392,
0.1485721468925476,
0.1151018813252449,
0.12684203684329987,
-0.05933119356632233,
0.12736287713050842,
-0.13969893753528595,
0.014065492898225784,
-0.044725239276885986,
-0.3633837401866913,
0.045183565467596054,
0.36638641357421875,
-0.00959050003439188,
0.08834342658519745,
-0.30883464217185974,
-0.05532316863536835,
-0.15354092419147491,
0.005734669975936413,
0.06788156926631927,
0.05103082209825516,
0.10823804140090942,
0.35471034049987793,
-0.17625603079795837,
-0.1333182454109192,
-0.04440423846244812,
-0.050568316131830215,
-0.0835273414850235,
0.04676687344908714,
-0.1288071572780609,
0.05296976491808891,
-0.3128186762332916,
-0.029124869033694267,
-0.08342576026916504,
-0.15415740013122559,
-0.0013825055211782455,
-0.3655604124069214,
-0.2009902000427246,
-0.10884173214435577,
-0.06540214270353317,
0.004391449969261885,
-0.045941539108753204,
0.13637082278728485,
0.016937248408794403,
0.08706258237361908,
0.2044345885515213,
-0.022713204845786095,
-0.07167555391788483,
0.08494219928979874,
-0.030207866802811623,
-0.09720881283283234,
0.0037111493293195963,
0.22080035507678986,
0.25105783343315125,
0.08557277172803879,
0.003314912784844637,
0.11783479899168015,
-0.08217275887727737,
-0.21174144744873047,
0.13375349342823029,
0.13844342529773712,
-0.06224967911839485,
0.025515083223581314,
0.005834953859448433,
0.0636187195777893,
-0.24538472294807434,
-0.3339223563671112,
-0.1603952795267105,
0.11400061100721359,
0.04154796525835991,
-0.06569013744592667,
-0.18137437105178833,
-0.11595699936151505,
-0.033368177711963654,
0.030010344460606575,
-0.068561851978302,
0.14102382957935333,
0.0021813102066516876,
0.24252177774906158,
-0.2082064300775528,
0.026753464713692665,
-0.06481000781059265,
-0.0018358430825173855,
-0.23335842788219452,
-0.12250945717096329,
-0.21061894297599792,
-0.09315121173858643,
0.1280488818883896,
-0.04141004756093025,
-0.09988478571176529,
0.11391186714172363,
0.0119004612788558,
0.24564626812934875,
0.08120208978652954,
0.305087149143219,
0.0728481188416481,
0.001929640187881887,
0.12763702869415283,
0.1991162747144699,
0.1123405322432518,
0.04498625546693802,
-0.14571791887283325,
0.3283842206001282,
-0.08543861657381058,
0.11101506650447845,
0.07290128618478775,
0.11728262156248093,
-0.04421019181609154,
-0.07308341562747955,
0.16023994982242584,
-0.027655113488435745,
-0.0988464280962944,
-0.0007641151896677911,
-0.09769628196954727,
0.009716036729514599,
-0.12955762445926666,
-0.1307491809129715,
-0.005074162967503071,
0.04978877678513527,
-0.16328953206539154,
0.00544000556692481,
-0.0915341004729271,
-0.11037829518318176,
0.1880396008491516,
-0.190656840801239,
0.03200500085949898,
0.0006967777735553682,
-0.06999636441469193,
0.1765580028295517,
0.13868816196918488,
-0.09272660315036774,
0.1922764927148819,
0.0495678186416626,
-0.09229674935340881,
-0.09220240265130997,
-0.14174696803092957,
-0.08600588142871857,
-0.10705514997243881,
0.06106983870267868,
0.07291281223297119,
-0.2037784308195114,
0.009172722697257996,
0.08883042633533478,
-0.0530967153608799,
-0.004011967685073614,
0.027909208089113235,
-0.03448501229286194,
-0.1341063529253006,
-0.03815861791372299,
-0.026719853281974792,
0.04965762048959732,
0.039957161992788315,
0.06415127217769623,
-0.05871028080582619,
0.15452730655670166,
-0.009721292182803154,
0.10489466786384583,
0.03542367368936539,
0.09606531262397766,
-0.1212737187743187,
0.03249203786253929,
0.021410329267382622,
-0.035702720284461975,
0.36706843972206116,
-0.12555330991744995,
-0.10442539304494858,
0.0645715594291687,
0.0044172341004014015,
-0.21584764122962952,
-0.11013013869524002,
-0.12799175083637238,
0.24902288615703583,
-0.21028508245944977,
0.19927194714546204,
-0.06484438478946686,
-0.18917584419250488,
-0.40313294529914856,
0.10704532265663147,
-0.0363151840865612,
-0.06694353371858597,
-0.09530545026063919,
0.05916628986597061,
-0.15303784608840942,
-0.0017952205380424857,
0.07437415421009064,
0.19019632041454315,
0.07011529058218002,
-0.23251037299633026,
-0.2877565026283264,
0.29359862208366394,
-0.029131533578038216,
0.07002731412649155,
0.016065360978245735,
0.030135033652186394,
0.10798328369855881,
-0.16005030274391174,
-0.1408846229314804,
0.09997235983610153,
0.10500159859657288,
-0.008999400772154331,
-0.07329476624727249,
-0.01878299191594124,
0.11572085320949554,
-0.14004987478256226,
0.07592441141605377,
0.10295511037111282,
-0.09561905264854431,
-0.06908313930034637,
0.14715059101581573,
0.022213386371731758,
0.028891516849398613,
-0.03341532126069069,
0.1694333851337433,
0.15758009254932404,
0.3033948242664337,
0.039665866643190384,
-0.20358432829380035,
-0.2327345907688141,
-0.06929624080657959,
0.11706714332103729,
0.10516226291656494,
-0.20345254242420197,
-0.09596908092498779,
0.162019744515419,
0.14182516932487488,
-0.042876362800598145,
0.01953315921127796,
0.24067974090576172,
-0.03545977920293808,
0.16838806867599487,
0.09260247647762299,
0.03442659229040146,
0.12537699937820435,
-0.0280286967754364,
-0.05518432334065437,
-0.047056637704372406,
0.1807568371295929,
-0.01673329435288906,
-0.2608092427253723,
0.22540578246116638,
0.013826830312609673,
-0.1301838755607605,
0.03407224267721176,
-0.05691852048039436,
0.05313824489712715,
-0.01685311272740364,
0.08722534030675888,
0.30211129784584045,
-0.029267728328704834,
0.057249750941991806,
0.03295115754008293,
-0.07957486063241959,
0.07171082496643066,
0.18647527694702148,
-0.1316061168909073,
-0.0386778824031353,
0.11144140362739563,
-0.04097054898738861,
0.15616728365421295,
-0.04419838637113571,
-0.0028483590576797724,
-0.03482705354690552,
-0.0919409915804863,
0.13391491770744324,
0.15228015184402466,
0.15969999134540558,
-0.16357563436031342,
-0.040338702499866486,
-0.18791534006595612,
0.03259573131799698,
0.1271175891160965,
-0.05417724326252937,
0.06678775697946548,
-0.10192787647247314,
-0.04993565008044243,
0.09664555639028549,
0.07333344966173172,
-0.09908000379800797,
-0.0374104268848896,
0.20789934694766998,
-0.003194758901372552,
-0.14771540462970734,
0.02079126238822937,
0.08779459446668625,
-0.13411268591880798,
-0.20169469714164734,
0.1279963254928589,
-0.04129733145236969,
-0.06381532549858093,
-0.02363351732492447,
0.025784460827708244,
-0.06545780599117279,
-0.11185383051633835,
-0.2533712387084961,
-0.04872924089431763,
-0.08023221045732498,
0.07774479687213898,
0.11728491634130478,
-0.02130548097193241,
0.015414398163557053,
-0.021628977730870247,
-0.1775881052017212,
0.00017139695410151035,
-0.23087593913078308,
-0.06973133981227875,
-0.29027649760246277,
0.06075552478432655,
0.03503923863172531,
0.13128647208213806,
0.0209365077316761,
-0.10492153465747833,
0.0532265305519104,
-0.2836064398288727,
-0.014280726201832294,
-0.1444324254989624,
-0.1144443228840828,
-0.027000989764928818,
0.0720512643456459,
-0.2159341722726822,
-0.04592185840010643,
0.2716326117515564,
-0.11069130152463913,
0.38000762462615967,
0.007326851133257151,
-0.01956258900463581,
-0.0694899708032608,
-0.03207021951675415,
-0.04038740694522858,
-0.15663357079029083,
-0.06858757883310318,
-0.17929914593696594,
-0.28136172890663147,
0.04769869148731232,
-0.023089995607733727,
0.2703839838504791,
-0.05120205879211426,
-0.06657684594392776,
-0.04500370845198631,
-0.2891167998313904,
0.264396607875824,
-0.06061968207359314,
-0.08503974229097366,
0.15081247687339783,
-0.026124905794858932,
0.016558611765503883,
0.15323637425899506,
0.012909311801195145,
-0.04623638838529587,
0.13420285284519196,
-0.05962197855114937,
-0.23227816820144653,
0.010653660632669926,
0.1093798354268074,
0.004740190226584673,
0.13620857894420624,
0.16293887794017792,
0.10833811014890671,
-0.05804292485117912,
0.0052309888415038586,
0.02156859263777733,
-0.06587658077478409,
0.4324091374874115,
-0.2569459080696106,
-0.07375519722700119,
0.10293002426624298,
0.04145054891705513,
-0.0053526111878454685,
-0.14062662422657013,
-0.004540577530860901,
0.0275185015052557,
0.20641016960144043,
-0.26787710189819336,
0.036301389336586,
-0.22122082114219666,
0.1551639437675476,
-0.04254407435655594,
-0.27084827423095703,
0.0726376622915268,
-0.07971566170454025,
0.02791723608970642,
-0.1086890771985054,
0.20559675991535187,
0.3318474292755127,
-0.07476998120546341,
-0.15553632378578186,
0.054698117077350616,
0.06785684823989868,
0.12088928371667862,
0.01800370402634144,
0.11149008572101593,
0.12403103709220886,
-0.03269831836223602,
0.20300066471099854,
0.01376278791576624,
0.1258316934108734,
0.052830833941698074,
-0.020396802574396133,
0.049881309270858765,
-0.0031544938683509827,
0.22419646382331848,
0.003239463781937957,
-0.010138239711523056,
0.08558502793312073,
0.10221561044454575,
0.2605862021446228,
-0.018128851428627968,
0.08648966252803802,
0.1729908287525177,
-0.0925513282418251,
0.07545115798711777,
-0.17740724980831146,
0.08914518356323242,
-0.11465447396039963,
0.09129232168197632,
0.26002025604248047,
-0.06629280745983124,
0.08610551059246063,
0.12203190475702286,
-0.3863764703273773,
0.13252627849578857,
0.11857662349939346,
-0.000779027002863586,
-0.043893732130527496,
-0.07023273408412933,
0.12029217183589935,
0.01369654480367899,
-0.08725541830062866,
-0.060391176491975784,
-0.06235499680042267,
0.023762140423059464,
-0.1807710975408554,
0.16904549300670624,
0.290122389793396,
0.03329417109489441,
-0.027486510574817657,
-0.027966056019067764,
0.10378476977348328,
0.1766301691532135,
0.08836536854505539,
-0.12326313555240631,
0.2724117636680603,
-0.1621437817811966,
0.15275034308433533,
-0.01181747019290924,
-0.034280166029930115,
0.3769618570804596,
0.10474932938814163,
0.03391869366168976,
0.19707563519477844,
0.049314387142658234,
-0.1167914867401123,
-0.15582144260406494,
0.03727401793003082,
0.07422421127557755,
0.09259156882762909,
-0.05726846307516098,
0.07822998613119125,
0.08263035863637924,
0.04588991403579712,
-0.29436224699020386,
-0.15497520565986633,
-0.025029022246599197,
-0.10911212861537933,
-0.05213915929198265,
-0.0936359390616417,
-0.19564363360404968,
0.07934310287237167,
0.01728864572942257,
-0.0985097885131836,
0.10969796031713486,
0.13878433406352997,
0.05125028267502785,
0.06995686888694763,
-0.0028095052111893892,
0.05166378244757652,
0.13699917495250702,
-0.034174539148807526,
-0.008213581517338753,
-0.16977518796920776,
0.12374670803546906,
0.029511159285902977,
-0.13798220455646515,
-0.1442938894033432,
-0.07088720798492432,
0.12768404185771942,
-0.056811071932315826,
0.1761629581451416,
-0.07970549166202545,
0.1003773882985115,
-0.10008569806814194,
-0.22105267643928528,
0.2165282666683197,
-0.1523401290178299,
0.1705508977174759,
0.11857610195875168,
0.13555370271205902,
-0.06925142556428909,
0.0768449679017067,
0.10264881700277328,
0.12042967230081558,
0.007001602090895176,
0.3115122318267822,
0.1405734419822693,
-0.05211211368441582,
0.0014857873320579529,
-0.14213335514068604,
0.0036266641691327095,
-0.04055032134056091,
0.23534922301769257,
0.15258640050888062,
-0.04322276636958122,
0.3537677526473999,
-0.11390585452318192,
0.11902336031198502,
0.03936843201518059,
-0.06295309215784073,
0.0021372996270656586,
0.20086032152175903,
0.30167722702026367,
-0.06887901574373245,
-0.028076983988285065,
-0.01297621987760067,
0.048454806208610535,
-0.18729077279567719,
0.09015211462974548,
-0.251688688993454,
-0.08993124216794968,
0.07956267148256302,
-0.08088130503892899,
-0.1914934515953064,
-0.16210930049419403,
0.2829890847206116,
0.19706720113754272,
-0.17378684878349304,
-0.08145349472761154,
-0.24764689803123474,
-0.06119440495967865,
0.20980671048164368,
-0.10533538460731506,
0.22059853374958038,
0.3183358907699585,
0.10022275149822235,
-0.19547322392463684,
-0.03597579896450043,
0.050017986446619034,
-0.11471342295408249,
0.048767972737550735,
-0.05855105444788933,
0.11670587956905365,
-0.014879001304507256,
-0.10930424183607101,
0.051023680716753006,
0.05661445111036301,
0.04693096503615379,
-0.12853659689426422,
-0.17125394940376282,
-0.09185376018285751,
0.04346809163689613,
-0.006204087287187576,
-0.12955020368099213,
0.2500227689743042,
0.023616645485162735,
-0.2907259166240692,
-0.21680432558059692,
0.10169319063425064,
-0.00005067175152362324,
0.2384784072637558,
-0.29996180534362793,
-0.0544513575732708,
-0.08717489242553711,
0.17414803802967072,
-0.05508728697896004,
0.31424984335899353,
0.012312567792832851,
0.023586353287100792,
-0.043406128883361816,
-0.022388199344277382,
0.0793783962726593,
-0.08007380366325378,
0.06401567906141281,
0.002823518356308341,
-0.06237539276480675,
-0.023417433723807335,
0.0036141613963991404,
-0.09645923972129822,
-0.000012542041986307595,
-0.08391483128070831,
0.062420234084129333,
-0.010550512000918388,
-0.221670001745224,
0.0648244321346283,
-0.19656679034233093,
-0.09906049072742462,
0.109348826110363,
-0.02281344123184681,
0.15762272477149963,
-0.13876542448997498,
0.07990990579128265,
0.03314642235636711,
-0.055588249117136,
-0.21083302795886993,
-0.19700679183006287,
-0.14150728285312653,
0.07495631277561188,
0.255296915769577,
0.053645409643650055,
0.07378809154033661,
-0.08140384405851364,
0.320553183555603,
-0.04990821331739426,
0.04998829960823059,
0.1069340705871582,
-0.13480974733829498,
-0.033076297491788864,
-0.12243422120809555,
-0.035173993557691574,
0.12659592926502228,
0.1031198650598526,
0.010884993709623814,
0.07362037152051926,
-0.2858491539955139,
-0.2251390963792801,
-0.2352411448955536,
0.14858651161193848,
0.17576013505458832,
-0.04794018343091011,
-0.015511510893702507,
-0.03420703485608101,
0.11091139912605286,
-0.0817839577794075,
0.1835784763097763,
0.3403904139995575,
-0.008255872875452042,
-0.27000439167022705,
-0.05721626803278923,
-0.12440156191587448,
0.042095720767974854,
-0.09943914413452148,
-0.08750710636377335,
-0.08288376778364182,
0.13175417482852936,
0.026412008330225945,
0.019910285249352455,
-0.06364636868238449,
0.08066638559103012,
-0.05098177492618561,
-0.0684695914387703,
-0.3408752977848053,
0.26851022243499756,
-0.021917393431067467,
-0.0959741473197937,
0.017914265394210815,
0.08405015617609024,
-0.04586222767829895,
0.01298176683485508,
0.08839336037635803,
0.10362308472394943,
-0.07342901080846786,
0.010676644742488861,
-0.1914328634738922,
0.048662394285202026,
-0.14056049287319183,
0.059023384004831314,
0.0754702016711235,
-0.08687489479780197,
0.11531941592693329,
-0.06108468025922775,
0.08295689523220062,
-0.1649143248796463,
0.08460171520709991,
-0.1269325166940689,
0.08921961486339569,
0.08193960785865784,
0.034251030534505844,
-0.14588254690170288,
-0.05561807379126549,
0.20737066864967346,
0.03676502779126167,
-0.1273159235715866,
-0.05245139077305794,
0.14460018277168274,
-0.021491823717951775,
-0.13814300298690796,
-0.21097025275230408,
-0.3170478940010071,
-0.08066666126251221,
0.11637422442436218,
0.034275539219379425,
0.1654350608587265,
-0.0823996514081955,
-0.11568587273359299,
-0.2471378594636917,
0.02858961559832096,
-0.07572879642248154,
-0.0023104038555175066,
0.10003070533275604,
0.1548648178577423,
-0.15782344341278076,
0.015217849984765053,
-0.04216398671269417,
0.17089416086673737,
-0.1508432775735855,
-0.08099047094583511,
-0.04134469851851463,
-0.03826775401830673,
0.06581874191761017,
-0.20140302181243896,
-0.2419729381799698,
-0.22717878222465515,
-0.1640167236328125,
0.010505487211048603,
0.2606147527694702,
-0.09453651309013367,
-0.2675847113132477,
0.08921904116868973,
0.06309916824102402,
-0.14476726949214935,
0.25010499358177185,
0.1505623161792755,
0.18308068811893463
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. following evaluations are recommended if they have not already been completed :Detailed and comprehensive (general, spine, and hand) orthopedic evaluationSkeletal survey as a baseline study of the extent and severity of overgrowthCT examination, possibly with three-dimensional reconstruction for individuals with significant scoliosis. As the vertebral bodies are commonly progressively deformed, this study can be very helpful for surgical planning.Pulmonology consultation, pulmonary function testing, and high-resolution CT examination of the chest for individuals with signs or symptoms suggestive of bullous pulmonary diseaseNeurodevelopmental evaluation for those with developmental delaysConsultation with a clinical geneticist and/or genetic counselorRehabilitation medicine evaluation, including fabrication of custom footwear and orthotics to address functional consequences of overgrowthOther imaging techniques (e.g., CT, MRI, and ultrasound examinations) are highly useful and should be determined by manifestations on examination and by the medical history.Treatment of ManifestationsAs with any complex and multisystem disorder, individuals | [
-0.11465005576610565,
-0.0652742013335228,
0.025552259758114815,
-0.24900005757808685,
0.11447625607252121,
-0.0721730887889862,
-0.011111444793641567,
-0.013844026252627373,
-0.10564302653074265,
0.044685736298561096,
0.14049166440963745,
0.16933563351631165,
-0.023766545578837395,
-0.008943254128098488,
-0.3272077739238739,
0.1515243947505951,
0.09397141635417938,
-0.2287791222333908,
-0.025893468409776688,
0.06791714578866959,
0.06562246382236481,
0.03265824913978577,
-0.03814130276441574,
0.08826042711734772,
0.04024837166070938,
-0.11377207189798355,
0.01996408775448799,
0.044958602637052536,
0.05461182817816734,
-0.05602392926812172,
-0.11602910608053207,
-0.12231411039829254,
-0.12222660332918167,
-0.27652981877326965,
0.022496363148093224,
-0.1867123395204544,
-0.16661714017391205,
-0.0037757172249257565,
0.03626784309744835,
-0.012119868770241737,
-0.12225820124149323,
0.025535233318805695,
0.1264580488204956,
-0.14262740314006805,
0.22402316331863403,
-0.04971194267272949,
0.06254987418651581,
0.0052587599493563175,
0.019909298047423363,
0.12356885522603989,
0.04564470797777176,
-0.01762150414288044,
0.10887971520423889,
0.043184202164411545,
0.015569628216326237,
-0.3100903332233429,
0.07795155048370361,
-0.1506795883178711,
-0.22392703592777252,
0.1407414972782135,
0.3527686595916748,
-0.004513048101216555,
-0.005871068220585585,
-0.2407645732164383,
-0.0023908421862870455,
-0.1352563202381134,
-0.10550052672624588,
0.14517387747764587,
0.14691436290740967,
-0.06633168458938599,
0.21949511766433716,
0.003228541696444154,
-0.03268744796514511,
-0.0684153139591217,
-0.05926310643553734,
0.01546917762607336,
0.06058944761753082,
-0.12170159816741943,
0.1557905673980713,
-0.31617188453674316,
-0.09882070124149323,
-0.07253195345401764,
-0.11838342994451523,
-0.0380186028778553,
-0.21945111453533173,
-0.057946670800447464,
-0.09903032332658768,
0.02862936444580555,
0.09322716295719147,
-0.0635514035820961,
0.12742143869400024,
-0.0523650199174881,
0.12206564843654633,
0.19417241215705872,
0.004914657678455114,
-0.12116621434688568,
0.19587862491607666,
0.09289306402206421,
-0.09184828400611877,
-0.008841835893690586,
0.1627625823020935,
0.33539074659347534,
0.04324096441268921,
-0.0935601070523262,
0.0604662224650383,
-0.09391460567712784,
-0.15960270166397095,
0.08770885318517685,
0.085832878947258,
-0.04720387980341911,
0.07325276732444763,
0.09423495084047318,
0.03874877095222473,
-0.1017451211810112,
-0.16738134622573853,
-0.09545048326253891,
-0.007315142545849085,
0.11186143755912781,
-0.13832299411296844,
-0.014696668833494186,
-0.04075738042593002,
-0.061071306467056274,
0.05677950009703636,
-0.05287507548928261,
0.20667318999767303,
0.0825766995549202,
0.2197384536266327,
-0.23081941902637482,
-0.08828694373369217,
0.00432470953091979,
0.06192928925156593,
-0.08499819040298462,
-0.03337457776069641,
-0.31893229484558105,
0.04861465469002724,
0.14848953485488892,
-0.1949552446603775,
-0.1868838518857956,
0.10290317982435226,
0.0652143806219101,
0.11592145264148712,
0.12107804417610168,
0.3418940305709839,
0.07729030400514603,
0.03562357276678085,
0.13199405372142792,
0.15062439441680908,
-0.015097059309482574,
0.032680489122867584,
0.013001340441405773,
0.22431284189224243,
-0.16986946761608124,
0.07861822098493576,
0.1458686888217926,
0.06645319610834122,
-0.1467350274324417,
0.04072367772459984,
0.32128000259399414,
-0.08221662789583206,
0.011086517944931984,
-0.026725366711616516,
-0.17424941062927246,
-0.0806041806936264,
-0.17168234288692474,
-0.13137754797935486,
0.07814332097768784,
0.06949996203184128,
-0.10295959562063217,
0.11196313798427582,
-0.0625632107257843,
-0.12249671667814255,
0.15791073441505432,
-0.12995178997516632,
0.17100006341934204,
0.01222311332821846,
0.11277376115322113,
0.12947283685207367,
0.10877452790737152,
-0.032438598573207855,
0.23246152698993683,
0.16103464365005493,
-0.11213338375091553,
-0.1383577138185501,
-0.12145953625440598,
-0.006167892832309008,
-0.099677674472332,
-0.05624280124902725,
0.09612897783517838,
-0.10803177952766418,
0.0943988710641861,
0.1194363385438919,
-0.1344672590494156,
-0.11626630276441574,
0.036613158881664276,
-0.03158117085695267,
-0.25985556840896606,
-0.09255680441856384,
-0.016713552176952362,
0.039411481469869614,
0.09753388911485672,
0.03571422025561333,
-0.11051133275032043,
0.19943244755268097,
-0.06055433303117752,
0.02331746742129326,
0.07705976814031601,
0.17478474974632263,
-0.28987178206443787,
0.21335019171237946,
0.07062787562608719,
-0.03979433700442314,
0.36926183104515076,
-0.09929624199867249,
-0.0028946679085493088,
0.03400286287069321,
0.005644726101309061,
-0.2517029643058777,
-0.0837666392326355,
-0.18248076736927032,
0.2585214674472809,
-0.21311786770820618,
0.17740292847156525,
-0.06296274811029434,
-0.1388089954853058,
-0.2892744243144989,
0.04782157018780708,
-0.09452037513256073,
-0.038100242614746094,
0.02169245108962059,
0.03308332711458206,
-0.10318946093320847,
-0.0134930070489645,
0.04377075284719467,
0.29466474056243896,
0.07637449353933334,
-0.30245527625083923,
-0.25910791754722595,
0.21172493696212769,
0.17217868566513062,
0.04750688374042511,
0.11906680464744568,
-0.09489212185144424,
0.10182429105043411,
-0.09864529222249985,
0.058192431926727295,
0.1549420952796936,
0.11719057708978653,
0.16801762580871582,
-0.14054885506629944,
0.007182346656918526,
0.113557368516922,
-0.12563657760620117,
0.13595116138458252,
0.019951259717345238,
-0.08528848737478256,
-0.027457648888230324,
0.03619541600346565,
-0.09382204711437225,
0.0004067294066771865,
-0.030183708295226097,
-0.020208030939102173,
0.11239486932754517,
0.3490382134914398,
0.027464300394058228,
-0.24348114430904388,
-0.1493498831987381,
-0.060511514544487,
0.17232491075992584,
-0.0211446825414896,
-0.20910736918449402,
-0.14561769366264343,
0.09984762221574783,
0.12282779812812805,
0.0971556156873703,
0.055838048458099365,
0.15403251349925995,
-0.04093048721551895,
0.06073983758687973,
0.07456128299236298,
0.07114546746015549,
0.1369488686323166,
0.03899077698588371,
-0.09667061269283295,
-0.004298956133425236,
0.23715123534202576,
0.08446631580591202,
-0.22585126757621765,
0.24620632827281952,
0.007334193214774132,
-0.09506335109472275,
0.14633753895759583,
0.015956507995724678,
-0.0025747567415237427,
0.014290913939476013,
0.04449411854147911,
0.20323528349399567,
0.06274969130754471,
0.04840349033474922,
0.11892539262771606,
-0.1520606279373169,
0.07114923745393753,
0.28731077909469604,
-0.22082345187664032,
-0.045386314392089844,
-0.019053315743803978,
-0.057528577744960785,
0.15147444605827332,
-0.13056519627571106,
-0.0007110812002792954,
0.03173764795064926,
0.00263673416338861,
0.1136276051402092,
-0.02751198038458824,
0.16469332575798035,
-0.09084384143352509,
0.06221326068043709,
-0.07074370980262756,
0.0878269225358963,
0.15806104242801666,
-0.09835125505924225,
0.19504672288894653,
-0.12055716663599014,
0.03858114406466484,
0.11519880592823029,
-0.10163601487874985,
0.003269836073741317,
-0.05736520141363144,
0.2077639251947403,
-0.052657704800367355,
-0.03848818689584732,
-0.060965489596128464,
0.058987174183130264,
-0.15720178186893463,
-0.1138601303100586,
0.10702553391456604,
-0.14845192432403564,
0.157172292470932,
-0.04214857891201973,
0.11532344669103622,
-0.08372028917074203,
-0.033646706491708755,
-0.22237849235534668,
-0.11847997456789017,
-0.10734275728464127,
-0.03534064069390297,
0.18112590909004211,
0.057426199316978455,
-0.02591787464916706,
-0.02486509457230568,
-0.15134012699127197,
-0.07191672921180725,
-0.1646077036857605,
-0.04368789494037628,
-0.36011171340942383,
0.2161429077386856,
-0.001703409245237708,
0.13404791057109833,
-0.011151455342769623,
-0.19134770333766937,
0.17463625967502594,
-0.22926348447799683,
0.023442810401320457,
-0.05854406580328941,
-0.08676809817552567,
0.049563661217689514,
-0.029680414125323296,
-0.17618882656097412,
-0.030820481479167938,
0.2486119121313095,
-0.08146502822637558,
0.2977149188518524,
0.012929593212902546,
-0.04189762845635414,
0.03283313661813736,
-0.0563240721821785,
0.047503478825092316,
-0.2098442018032074,
0.12981991469860077,
-0.21054908633232117,
-0.21870848536491394,
-0.061756934970617294,
0.03271091356873512,
0.07685063779354095,
-0.08397405594587326,
-0.05172492191195488,
0.0758250281214714,
-0.21678023040294647,
0.20666097104549408,
-0.04384063184261322,
-0.09676580876111984,
0.18475642800331116,
-0.08213672786951065,
0.15112760663032532,
0.1353856325149536,
0.060605619102716446,
0.09832041710615158,
0.0885114073753357,
-0.07862095534801483,
-0.133941188454628,
-0.07731836289167404,
0.007660267874598503,
0.04218294844031334,
0.1488606035709381,
0.09268033504486084,
-0.02985336445271969,
-0.07965739071369171,
-0.01966783031821251,
-0.008453872054815292,
-0.11943670362234116,
0.246436208486557,
-0.14027805626392365,
-0.08658428490161896,
0.007099941838532686,
0.03947557508945465,
0.11369328945875168,
-0.03714701160788536,
-0.12978050112724304,
-0.012972807511687279,
-0.04681779816746712,
-0.21451489627361298,
0.09595496952533722,
-0.15795068442821503,
0.15570352971553802,
0.032909292727708817,
-0.34484028816223145,
0.06550223380327225,
-0.15648281574249268,
0.11869090795516968,
0.005028979852795601,
0.2338753044605255,
0.21957780420780182,
-0.10400800406932831,
-0.008442332968115807,
0.19118937849998474,
-0.024444470182061195,
0.09347538650035858,
-0.05901124328374863,
0.017604170367121696,
0.16279098391532898,
-0.11517497897148132,
0.225765660405159,
-0.20956666767597198,
0.14723272621631622,
0.12124951183795929,
-0.05529553070664406,
-0.07998253405094147,
0.11600804328918457,
0.09903177618980408,
0.10934831947088242,
-0.02139268070459366,
0.01176472008228302,
-0.06130851432681084,
0.23206768929958344,
-0.05167851597070694,
0.1500360369682312,
0.10784634202718735,
-0.12033368647098541,
0.0013937677722424269,
-0.1251043975353241,
-0.028396863490343094,
-0.11516297608613968,
0.0438244603574276,
0.16580736637115479,
-0.05047499015927315,
-0.03324400633573532,
0.11412739753723145,
-0.2824622392654419,
0.07598301023244858,
0.05966554209589958,
-0.018973330035805702,
-0.08784902095794678,
0.0022670263424515724,
0.05994226410984993,
0.0214835274964571,
-0.018447604030370712,
-0.15879546105861664,
0.09855671226978302,
0.16215437650680542,
-0.06156640499830246,
0.21168433129787445,
0.23664645850658417,
0.036109209060668945,
-0.02735181525349617,
0.0053728483617305756,
0.1428050398826599,
0.10479944199323654,
0.039608653634786606,
-0.0539366640150547,
0.15171365439891815,
-0.09935405105352402,
0.04906246438622475,
0.03712884709239006,
-0.06148185953497887,
0.2818637490272522,
0.11254046857357025,
-0.02476336993277073,
0.15097135305404663,
-0.03499733656644821,
-0.1778067648410797,
-0.16397637128829956,
0.11328679323196411,
0.11782689392566681,
0.03125615045428276,
0.006282674614340067,
-0.05739832669496536,
0.01258185226470232,
0.15664388239383698,
-0.18704752624034882,
-0.21883068978786469,
0.10615275800228119,
-0.09593281894922256,
-0.06878090649843216,
-0.04593273997306824,
-0.11790183186531067,
-0.010757395066320896,
0.010979092679917812,
-0.016772691160440445,
0.11581841856241226,
-0.05370344966650009,
-0.013097384013235569,
0.16722935438156128,
-0.07731245458126068,
0.0042076208628714085,
0.09591329842805862,
-0.09616974741220474,
-0.0887642428278923,
-0.0571717694401741,
0.057614702731370926,
0.0945940762758255,
-0.24729101359844208,
-0.09506336599588394,
-0.09222206473350525,
0.015792250633239746,
-0.10420940816402435,
0.13363967835903168,
-0.08566699177026749,
-0.06742483377456665,
-0.1150759756565094,
-0.27683234214782715,
0.06108837202191353,
-0.12265337258577347,
0.17290399968624115,
0.09399925917387009,
0.0945829227566719,
0.00019960961071774364,
0.008454938419163227,
0.019981101155281067,
0.1520075798034668,
0.07446198910474777,
0.3585565388202667,
0.02087673731148243,
-0.037779323756694794,
0.03343122452497482,
-0.024361230432987213,
0.06345997005701065,
-0.0577365979552269,
0.1886547952890396,
0.08689045161008835,
-0.10616982728242874,
0.3537974953651428,
-0.1552889496088028,
0.2014922946691513,
0.04597127065062523,
-0.012304648756980896,
0.02604495733976364,
0.21347089111804962,
0.20931798219680786,
-0.1324751079082489,
0.01951371133327484,
0.03290954977273941,
-0.032775796949863434,
-0.13397249579429626,
0.06033211573958397,
-0.11915849149227142,
-0.08764054626226425,
0.043644823133945465,
0.054407138377428055,
-0.18193461000919342,
-0.16884638369083405,
0.2537257671356201,
0.12616004049777985,
-0.1220477893948555,
-0.10698886960744858,
-0.29370394349098206,
0.027553696185350418,
0.07580502331256866,
-0.1467433124780655,
0.22546473145484924,
0.23045045137405396,
0.008124584332108498,
-0.03381064906716347,
-0.05716259405016899,
0.11918207257986069,
-0.15966789424419403,
0.057772792875766754,
-0.09435892105102539,
0.10719259083271027,
-0.018548501655459404,
-0.05621592327952385,
-0.0015190384583547711,
-0.04467783123254776,
0.07943908870220184,
-0.11962346732616425,
-0.11357586830854416,
-0.04404201731085777,
0.08567260950803757,
-0.05555269867181778,
-0.2018342763185501,
0.15396331250667572,
-0.01231308188289404,
-0.23360984027385712,
-0.01135273091495037,
0.05340851843357086,
0.04347763583064079,
0.23743736743927002,
-0.25934743881225586,
0.03336630016565323,
-0.016661062836647034,
0.18582765758037567,
-0.09035738557577133,
0.26214006543159485,
-0.01660052314400673,
-0.0777035653591156,
-0.10700785368680954,
-0.11528430879116058,
0.14963839948177338,
0.01699601300060749,
0.09951842576265335,
0.04728703200817108,
-0.08380366861820221,
0.05731203779578209,
0.008236674591898918,
-0.10031019151210785,
-0.03844403848052025,
-0.0776136964559555,
0.04428344592452049,
-0.008030309341847897,
-0.1839255690574646,
-0.09784933924674988,
-0.12463893741369247,
-0.07727740705013275,
0.11806254833936691,
0.05556558072566986,
0.17607063055038452,
-0.25327610969543457,
-0.01756260357797146,
0.09767377376556396,
-0.25876957178115845,
-0.14386354386806488,
-0.10378226637840271,
-0.1342100352048874,
0.14086170494556427,
0.18271507322788239,
-0.09691216051578522,
-0.012734789401292801,
-0.048274245113134384,
0.4685204029083252,
0.004526106640696526,
0.056271132081747055,
-0.006047221831977367,
-0.09616755694150925,
0.013104003854095936,
-0.1438586264848709,
0.07746067643165588,
0.0832415372133255,
0.06600866466760635,
-0.039499301463365555,
0.18427404761314392,
-0.12646043300628662,
-0.1712178885936737,
-0.17223338782787323,
0.14098615944385529,
0.21892039477825165,
0.0567496232688427,
-0.04352264106273651,
0.009810816496610641,
0.14473533630371094,
-0.1716827154159546,
0.11372168362140656,
0.3222685158252716,
0.16115635633468628,
-0.3286532759666443,
-0.010341654531657696,
-0.24367594718933105,
0.0850975513458252,
0.0035040227230638266,
-0.03648648038506508,
-0.0410788357257843,
0.07362113147974014,
-0.08964994549751282,
0.00205442332662642,
-0.11745772510766983,
0.0802094116806984,
-0.0780988410115242,
0.03013676404953003,
-0.2026357203722,
0.3597947955131531,
-0.02257985807955265,
-0.11404424160718918,
-0.04510265961289406,
0.1315392106771469,
-0.0009397033718414605,
-0.03043406456708908,
-0.009221354499459267,
0.0035545714199543,
-0.01442808285355568,
-0.011838369071483612,
-0.12585674226284027,
0.029152099043130875,
-0.007631246000528336,
-0.06957115978002548,
0.06211278587579727,
-0.04868103936314583,
0.15411610901355743,
-0.057792529463768005,
0.14094795286655426,
-0.013466771692037582,
0.01843099109828472,
-0.022294413298368454,
0.009706015698611736,
0.033264484256505966,
0.14374598860740662,
-0.06477838009595871,
-0.11942090094089508,
0.10023180395364761,
0.016944896429777145,
-0.0974416583776474,
-0.04116866737604141,
0.11446058750152588,
-0.06544318050146103,
-0.10057137906551361,
-0.25390633940696716,
-0.19216583669185638,
-0.1809857040643692,
0.07494521886110306,
-0.05998930707573891,
0.08968041837215424,
-0.11020171642303467,
-0.12070143967866898,
-0.19798773527145386,
0.014180011115968227,
-0.09355959296226501,
0.05615429952740669,
0.05342916026711464,
0.1895301192998886,
-0.08096161484718323,
-0.0020421899389475584,
-0.11260300874710083,
-0.058097098022699356,
-0.07067106664180756,
-0.062185466289520264,
-0.08685635775327682,
0.1396026909351349,
0.07012004405260086,
-0.16481250524520874,
-0.16793356835842133,
-0.23381981253623962,
-0.12920746207237244,
-0.0012857262045145035,
0.12449964135885239,
0.001598085043951869,
-0.20396536588668823,
0.04936573654413223,
-0.02935301512479782,
-0.11633775383234024,
0.28916579484939575,
0.12420465052127838,
0.0839603915810585
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. suggestive of bullous pulmonary diseaseNeurodevelopmental evaluation for those with developmental delaysConsultation with a clinical geneticist and/or genetic counselorRehabilitation medicine evaluation, including fabrication of custom footwear and orthotics to address functional consequences of overgrowthOther imaging techniques (e.g., CT, MRI, and ultrasound examinations) are highly useful and should be determined by manifestations on examination and by the medical history.Treatment of ManifestationsAs with any complex and multisystem disorder, individuals with PS benefit from a coordinated and multidisciplinary clinical approach tailored to the individual's specific needs and manifestations.Overgrowth is an ongoing issue for many individuals with PS. The management is complex and highly dependent on the nature of the overgrowth, which can vary substantially.For overgrowth of tubular bones, epiphysiostasis and epiphysiodesis should be the mainstays of management. One intervention that the authors have found to be detrimental to individuals with PS is distraction osteotomy (so- | [
-0.04690421000123024,
0.06289183348417282,
-0.0744074136018753,
-0.14984101057052612,
0.23800800740718842,
0.19634844362735748,
0.029203517362475395,
-0.24294935166835785,
-0.01825697533786297,
-0.024980692192912102,
0.10060446709394455,
0.08579529821872711,
0.026944570243358612,
0.20497794449329376,
-0.37927812337875366,
0.1365177482366562,
-0.05751475319266319,
-0.03274420648813248,
-0.03437431901693344,
0.024048838764429092,
0.0021890364587306976,
0.04499787837266922,
0.042699217796325684,
0.2089434713125229,
0.08009976148605347,
-0.0664813220500946,
0.17206132411956787,
0.08180829137563705,
0.12225620448589325,
-0.020100900903344154,
-0.10193811357021332,
0.033604830503463745,
0.10454074293375015,
-0.3944208025932312,
0.22534218430519104,
-0.13796068727970123,
-0.24501927196979523,
-0.13276930153369904,
0.19822131097316742,
-0.026386281475424767,
-0.14953769743442535,
0.13261649012565613,
0.18000182509422302,
-0.054787732660770416,
0.13204194605350494,
-0.030079513788223267,
0.0916006863117218,
0.030999988317489624,
0.06191630661487579,
0.1377691924571991,
0.01382397674024105,
-0.0005602471646852791,
0.144768625497818,
0.0579155758023262,
0.020363928750157356,
-0.23318813741207123,
0.20521017909049988,
-0.0019049522234126925,
-0.16212889552116394,
-0.05244671553373337,
0.10356492549180984,
0.030417194589972496,
-0.1666528433561325,
-0.09323381632566452,
0.020538153126835823,
-0.2627813220024109,
-0.2546621263027191,
-0.03577987849712372,
0.08824973553419113,
0.01759130135178566,
0.18989893794059753,
-0.1596594601869583,
-0.12397546321153641,
-0.03703305870294571,
0.023282768204808235,
-0.19411948323249817,
0.028320787474513054,
-0.2242332547903061,
0.040035560727119446,
-0.13400313258171082,
0.017819847911596298,
-0.16282455623149872,
-0.2730502188205719,
0.11625265330076218,
-0.00928245484828949,
-0.1831110715866089,
-0.39281123876571655,
0.10750440508127213,
0.10821669548749924,
-0.11400970816612244,
0.1435331106185913,
-0.13613373041152954,
0.33600783348083496,
0.04143418371677399,
0.0797877162694931,
-0.025714855641126633,
0.07155641913414001,
-0.03263162076473236,
0.031909048557281494,
-0.11860500276088715,
0.19211642444133759,
0.23358626663684845,
0.01404430903494358,
0.22356154024600983,
-0.11308129131793976,
-0.20209169387817383,
-0.1526585966348648,
0.08964407444000244,
0.0181997362524271,
0.023321185261011124,
-0.042996373027563095,
-0.20571087300777435,
-0.14819249510765076,
-0.03577209636569023,
-0.30613651871681213,
-0.1883695274591446,
0.07682435214519501,
0.1913461983203888,
-0.10316602885723114,
-0.12960588932037354,
-0.009006768465042114,
-0.06731917709112167,
0.08765089511871338,
0.08621134608983994,
0.047245558351278305,
0.20766739547252655,
0.2683600187301636,
-0.034874606877565384,
-0.0716780349612236,
-0.06240773946046829,
0.23726840317249298,
-0.15717749297618866,
0.058951716870069504,
-0.2650529742240906,
-0.14595210552215576,
-0.09728331118822098,
-0.12328802794218063,
-0.0823439434170723,
0.024320218712091446,
0.18960627913475037,
0.3112546503543854,
0.08804313093423843,
0.5367153286933899,
0.17840130627155304,
0.048637423664331436,
-0.010644383728504181,
0.010808853432536125,
0.12493320554494858,
0.037453543394804,
0.018041707575321198,
0.15516039729118347,
-0.2747584581375122,
0.16142919659614563,
0.1534903198480606,
0.21725884079933167,
-0.06546901911497116,
0.11355283111333847,
0.03759131208062172,
-0.11751007288694382,
-0.21747250854969025,
0.012456489726901054,
-0.12043990194797516,
0.07093564420938492,
-0.31165269017219543,
-0.031180398538708687,
0.28470346331596375,
0.1907985806465149,
-0.053273577243089676,
-0.013687845319509506,
-0.08549074083566666,
0.12012360244989395,
0.098054900765419,
-0.14874017238616943,
-0.050271160900592804,
0.0363105833530426,
0.015499444678425789,
0.24504664540290833,
0.008309162221848965,
-0.17036072909832,
0.11273927241563797,
0.04812277853488922,
0.066874198615551,
0.01759955659508705,
-0.000047161232942016795,
-0.09233494848012924,
-0.19893793761730194,
0.022227533161640167,
0.24317772686481476,
-0.07641910016536713,
0.18221279978752136,
0.08396095782518387,
0.1267462819814682,
0.040799617767333984,
-0.024357564747333527,
0.08991343528032303,
-0.29588085412979126,
-0.009002543054521084,
-0.12328951060771942,
0.07405507564544678,
0.10040352493524551,
0.12018357962369919,
0.01757045090198517,
0.18698924779891968,
-0.07044407725334167,
-0.025142520666122437,
0.038868654519319534,
0.12761224806308746,
-0.07602734118700027,
0.1810315102338791,
-0.1123814582824707,
-0.20960064232349396,
0.20481985807418823,
-0.07232041656970978,
0.17559754848480225,
0.1200195774435997,
-0.1558218002319336,
-0.2615584135055542,
0.07767323404550552,
-0.2158474326133728,
0.1082368865609169,
-0.21897530555725098,
0.008265642449259758,
-0.15397563576698303,
-0.13025011122226715,
-0.2705691158771515,
0.025871263816952705,
-0.20019212365150452,
0.01889430359005928,
-0.20239850878715515,
0.06215421482920647,
0.01896263100206852,
0.08000297099351883,
0.03587980195879936,
0.20019850134849548,
-0.05014451965689659,
-0.3667708933353424,
-0.10369540750980377,
0.01458746287971735,
0.07495824992656708,
0.15805765986442566,
-0.0407806858420372,
0.049460552632808685,
0.05459835007786751,
-0.16593903303146362,
-0.08090157061815262,
0.054800182580947876,
0.26657596230506897,
-0.06636235862970352,
-0.15422044694423676,
-0.09362774342298508,
-0.05942603945732117,
-0.16946935653686523,
0.2282836139202118,
-0.0651666671037674,
-0.08401622623205185,
0.005642216186970472,
0.020982133224606514,
-0.025782981887459755,
0.1278577744960785,
0.05427239090204239,
-0.1408756971359253,
0.18566958606243134,
0.11485902965068817,
-0.1383207142353058,
-0.34127509593963623,
-0.07582366466522217,
-0.0960039272904396,
0.19998930394649506,
-0.05384546145796776,
-0.3157222270965576,
-0.13192172348499298,
0.1105339527130127,
0.18700483441352844,
0.03732195124030113,
0.0003576340095605701,
0.08489543944597244,
0.022105125710368156,
-0.10045187920331955,
0.18140695989131927,
-0.06879604607820511,
0.19029732048511505,
-0.04184005409479141,
-0.11156116425991058,
-0.01368293259292841,
0.22200000286102295,
0.18278273940086365,
-0.07933627814054489,
0.47488534450531006,
0.14770130813121796,
-0.14467459917068481,
0.17166458070278168,
0.11767496913671494,
-0.0036808084696531296,
-0.018366439267992973,
0.07419678568840027,
-0.0071899681352078915,
-0.05935003235936165,
0.03394914045929909,
0.16826839745044708,
-0.19211138784885406,
0.09533652663230896,
0.11143438518047333,
-0.15852545201778412,
0.09477996826171875,
-0.13569194078445435,
-0.1229708269238472,
0.013556968420743942,
-0.038854047656059265,
0.0591328889131546,
0.028337914496660233,
0.08110898733139038,
-0.11940807104110718,
0.10314247012138367,
0.1312064677476883,
-0.07616744935512543,
0.026077929884195328,
0.031937744468450546,
0.10466451197862625,
-0.116845041513443,
-0.074288010597229,
0.1668262928724289,
-0.1201120987534523,
0.1560753583908081,
0.21630391478538513,
-0.06116563826799393,
0.09915682673454285,
0.15211819112300873,
0.268930047750473,
-0.09099933505058289,
-0.10022749751806259,
-0.09813380986452103,
0.049143072217702866,
-0.34874311089515686,
-0.2976703643798828,
0.12193753570318222,
0.08772538602352142,
-0.09108442068099976,
-0.027750330045819283,
0.06378661841154099,
-0.17691025137901306,
-0.0016843697521835566,
-0.3501221537590027,
0.05515708774328232,
-0.2478015422821045,
-0.08020225912332535,
-0.0024449676275253296,
-0.11104092001914978,
-0.003053867956623435,
0.018267640843987465,
-0.26672613620758057,
-0.0911751314997673,
-0.14731067419052124,
0.03307033330202103,
-0.24403566122055054,
0.23007416725158691,
-0.15107519924640656,
0.03431631252169609,
0.09798270463943481,
-0.019785355776548386,
0.14640705287456512,
-0.18234360218048096,
-0.01854385994374752,
0.10235340148210526,
-0.24912029504776,
0.07616250962018967,
0.06973176449537277,
-0.17747187614440918,
0.006757146213203669,
0.06711449474096298,
0.11372560262680054,
0.19199304282665253,
-0.089756540954113,
0.0008429415174759924,
-0.2091497927904129,
-0.04169868677854538,
0.18065062165260315,
-0.21078024804592133,
0.05702116712927818,
-0.16391725838184357,
-0.30463117361068726,
-0.1563475877046585,
-0.051526542752981186,
0.08435921370983124,
0.14196984469890594,
-0.02101615071296692,
0.04093840345740318,
-0.15913088619709015,
0.19661132991313934,
-0.0165784303098917,
-0.29686275124549866,
0.10931306332349777,
0.10638710856437683,
0.13674096763134003,
0.18249855935573578,
0.21983018517494202,
0.1363571286201477,
0.12955845892429352,
-0.18400290608406067,
-0.2207634150981903,
-0.13612423837184906,
0.21239319443702698,
-0.027519401162862778,
0.19673065841197968,
0.14799556136131287,
0.005612450651824474,
-0.21629349887371063,
-0.29765090346336365,
-0.12307038903236389,
-0.02140439674258232,
0.3928810656070709,
-0.2512994110584259,
0.029345085844397545,
0.05169156193733215,
-0.019937962293624878,
0.12106644362211227,
-0.12017557770013809,
-0.017741728574037552,
-0.12794345617294312,
0.11766792833805084,
-0.07070160657167435,
-0.07382477074861526,
-0.20042192935943604,
0.33242806792259216,
-0.022818947210907936,
-0.3371531069278717,
-0.043156109750270844,
-0.12485042214393616,
0.25939318537712097,
0.012545445933938026,
0.2615302503108978,
0.306572824716568,
-0.04699316248297691,
-0.10008937865495682,
0.06525346636772156,
-0.010039075277745724,
-0.09570212662220001,
-0.11011958122253418,
-0.02123982645571232,
0.31255242228507996,
0.05513422563672066,
0.22299730777740479,
-0.1872224360704422,
0.07060807943344116,
0.23138771951198578,
-0.1230727955698967,
-0.07074417173862457,
-0.23428407311439514,
0.1710919290781021,
0.10493119060993195,
-0.1095963642001152,
-0.0468439944088459,
0.02442925237119198,
0.20480874180793762,
-0.03968450799584389,
0.09172940999269485,
0.24133558571338654,
-0.16010475158691406,
0.09650912880897522,
-0.09728407114744186,
0.06447502970695496,
-0.1930253505706787,
0.07208852469921112,
0.13755352795124054,
-0.06750654429197311,
0.023389015346765518,
-0.011065599508583546,
-0.5001518130302429,
0.25543013215065,
0.16867557168006897,
-0.20025303959846497,
-0.006632223259657621,
-0.0853821411728859,
-0.07183419913053513,
-0.13562801480293274,
-0.02869616448879242,
-0.04158180207014084,
-0.17338842153549194,
0.3106721043586731,
-0.20883947610855103,
0.15935833752155304,
0.05238281935453415,
0.0657644122838974,
-0.06727399677038193,
-0.025888746604323387,
0.11140099912881851,
0.1845322698354721,
0.12935517728328705,
-0.1140650138258934,
0.22442886233329773,
-0.09993266314268112,
0.2092420905828476,
-0.0002402329264441505,
-0.05152760446071625,
0.18100591003894806,
0.056968048214912415,
-0.025929667055606842,
0.19195041060447693,
0.17170870304107666,
0.03841415420174599,
-0.00673970440402627,
0.026764126494526863,
0.04079620912671089,
-0.13976790010929108,
0.007157089654356241,
0.1709243804216385,
-0.08156026154756546,
0.044983264058828354,
-0.1249321848154068,
-0.09275491535663605,
0.10106297582387924,
-0.07951793819665909,
-0.10030204802751541,
-0.18589834868907928,
-0.14938083291053772,
-0.17314332723617554,
-0.05384809523820877,
-0.09977985173463821,
0.18180061876773834,
-0.2160269021987915,
-0.11355029791593552,
0.0826125219464302,
-0.07718291878700256,
-0.062031783163547516,
-0.01548565924167633,
-0.25333431363105774,
-0.2030174881219864,
-0.11378604173660278,
0.07612644881010056,
0.06610991060733795,
-0.2857370674610138,
0.08669045567512512,
-0.06375453621149063,
0.1247338354587555,
-0.02924451045691967,
0.20953905582427979,
0.06607481837272644,
0.017086435109376907,
-0.09504394978284836,
-0.08780383318662643,
0.21195076406002045,
-0.09818415343761444,
0.24532024562358856,
0.13257208466529846,
0.09270453453063965,
-0.11817490309476852,
0.0898129791021347,
0.2571370303630829,
0.055990081280469894,
0.12416253238916397,
0.25941330194473267,
-0.11595884710550308,
0.29716283082962036,
-0.00594813609495759,
-0.10642822831869125,
0.031370293349027634,
-0.1269700974225998,
0.41060560941696167,
0.07711532711982727,
-0.09020894765853882,
0.10119092464447021,
-0.11950494349002838,
0.23424726724624634,
0.017615104094147682,
-0.009422401897609234,
0.07079964876174927,
0.23271451890468597,
0.1840759664773941,
-0.1470843404531479,
-0.009533154778182507,
-0.12798413634300232,
0.08243632316589355,
-0.002096071606501937,
0.3208193778991699,
-0.03193031623959541,
-0.1634887158870697,
0.05709689483046532,
0.012665076181292534,
0.07454265654087067,
0.040405284613370895,
0.21212536096572876,
0.2300267368555069,
-0.16428802907466888,
-0.23818640410900116,
-0.27029654383659363,
-0.07047692686319351,
0.06733261793851852,
-0.05379369854927063,
0.18963508307933807,
0.1070261150598526,
0.328389972448349,
0.11854791641235352,
0.06068037077784538,
0.06546840816736221,
-0.10423100739717484,
-0.019825732335448265,
0.09029003977775574,
0.11643269658088684,
0.06660878658294678,
-0.11468709260225296,
0.07914263010025024,
0.24114155769348145,
0.008974941447377205,
-0.07065647840499878,
-0.012866934761404991,
-0.29617154598236084,
-0.15826235711574554,
-0.04797342047095299,
-0.16114936769008636,
0.02531699649989605,
0.16826915740966797,
-0.2457953244447708,
-0.1706344038248062,
0.1559227854013443,
-0.01698560081422329,
0.14663079380989075,
-0.4498887360095978,
0.03851650282740593,
-0.2786809504032135,
0.020206831395626068,
-0.03606153279542923,
0.28836843371391296,
-0.12930861115455627,
-0.011107459664344788,
-0.0033459181431680918,
-0.2769007682800293,
0.16316087543964386,
-0.04554760083556175,
0.06756451725959778,
0.09719330072402954,
-0.1618795096874237,
0.18762817978858948,
0.15719838440418243,
0.009428322315216064,
-0.027164025232195854,
-0.008521867915987968,
-0.12667995691299438,
0.03443150967359543,
-0.007173543330281973,
-0.00904924888163805,
-0.15176092088222504,
-0.10251481831073761,
0.08731075376272202,
0.16572390496730804,
0.1480380892753601,
-0.18074347078800201,
0.03274433687329292,
0.0735483318567276,
-0.10966335982084274,
-0.16830626130104065,
-0.035255808383226395,
-0.039777182042598724,
0.12247729301452637,
0.20664864778518677,
-0.0869312435388565,
-0.009919083677232265,
-0.14565925300121307,
0.2527669370174408,
-0.13851845264434814,
-0.1281394362449646,
-0.40072381496429443,
-0.12135033309459686,
-0.25232774019241333,
0.010700163431465626,
0.0628654807806015,
0.08587367832660675,
0.13386109471321106,
-0.042203810065984726,
0.09135589748620987,
0.1755455732345581,
-0.09031322598457336,
-0.028688637539744377,
0.13886089622974396,
0.16300734877586365,
-0.022166291251778603,
-0.13576459884643555,
-0.07027213275432587,
0.09209910035133362,
-0.20167075097560883,
0.004637638572603464,
0.3313024044036865,
-0.1342998892068863,
-0.4266308546066284,
-0.16172648966312408,
-0.3035844564437866,
-0.17361295223236084,
0.07240110635757446,
0.06217237561941147,
-0.227638378739357,
0.04522967338562012,
-0.14754940569400787,
0.12008760869503021,
-0.1409434974193573,
0.11227606981992722,
0.009817234240472317,
0.10127675533294678,
-0.11518264561891556,
0.4188137352466583,
0.1370089054107666,
-0.13798017799854279,
0.028919031843543053,
0.04547228664159775,
-0.021337443962693214,
-0.08898096531629562,
-0.0680341124534607,
-0.11404387652873993,
0.07882911711931229,
0.055871620774269104,
-0.3480762839317322,
0.13369716703891754,
-0.362155556678772,
-0.1731218546628952,
-0.0972735732793808,
-0.0054461280815303326,
0.285660982131958,
-0.04112953320145607,
-0.004374900832772255,
-0.0725439190864563,
0.266631156206131,
-0.05193599313497543,
0.21260900795459747,
-0.1034698486328125,
0.11639142036437988,
-0.006527033168822527,
-0.2376958131790161,
0.18812920153141022,
0.16721637547016144,
-0.23189139366149902,
0.08533318340778351,
-0.0396125502884388,
-0.12654247879981995,
-0.047073185443878174,
-0.14427286386489868,
-0.1215391680598259,
-0.01769324019551277,
0.1614118367433548,
-0.15363316237926483,
-0.05939345806837082,
-0.29997414350509644,
-0.1471097767353058,
-0.08519682288169861,
0.08690274506807327,
0.11058884859085083,
-0.008645626716315746,
-0.03618216514587402,
0.12651900947093964,
-0.094828762114048,
0.10157608240842819,
-0.1880941092967987,
0.3058737814426422,
-0.08760197460651398,
0.05739428475499153,
0.12729820609092712,
0.10370144993066788,
0.1669234037399292,
-0.22127269208431244,
-0.06817464530467987,
-0.018414238467812538,
0.12761884927749634,
-0.10425221174955368,
0.15844926238059998,
0.1257939338684082,
-0.3910190165042877,
-0.02841428481042385,
-0.014590191654860973,
-0.10474535077810287,
0.17840121686458588,
0.23422841727733612,
-0.0016164110274985433
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. multisystem disorder, individuals with PS benefit from a coordinated and multidisciplinary clinical approach tailored to the individual's specific needs and manifestations.Overgrowth is an ongoing issue for many individuals with PS. The management is complex and highly dependent on the nature of the overgrowth, which can vary substantially.For overgrowth of tubular bones, epiphysiostasis and epiphysiodesis should be the mainstays of management. One intervention that the authors have found to be detrimental to individuals with PS is distraction osteotomy (so-called Ilizarov procedure) performed on the normal (shorter) limbs. Readers are referred to a review and conference report for more details on this complex issue .The skeletal overgrowth of PS can result in significant biomechanical and functional compromise. Because of this, ongoing and comprehensive rehabilitation medicine care, including physical and occupational therapy, is important for many individuals. In addition, many individuals with PS develop substantial needs for custom-designed footwear or orthotics due to leg-length | [
-0.1376754492521286,
-0.0030649190302938223,
-0.017880667001008987,
-0.1535043865442276,
0.23879343271255493,
0.1608465313911438,
0.1776762157678604,
-0.32267698645591736,
0.036385443061590195,
0.068437859416008,
0.09198565781116486,
0.0003551494737621397,
0.019770510494709015,
0.06966467201709747,
-0.4480606019496918,
0.2528758645057678,
-0.047195177525281906,
-0.007299714256078005,
-0.08439099788665771,
0.0706084817647934,
0.03913075476884842,
0.021123075857758522,
0.11519241333007812,
0.23705178499221802,
0.1040739193558693,
-0.06003285199403763,
0.26527002453804016,
0.06333033740520477,
0.07693614810705185,
-0.16933105885982513,
-0.11972463130950928,
0.06557707488536835,
0.11298617720603943,
-0.4139295220375061,
0.16904376447200775,
-0.3070611357688904,
-0.28263214230537415,
-0.04660677909851074,
0.19641247391700745,
0.14030401408672333,
-0.13440260291099548,
0.01717117801308632,
0.2307094931602478,
-0.1622634381055832,
0.23316766321659088,
0.07205154746770859,
0.04529986530542374,
0.05925067886710167,
0.015448419377207756,
0.11981304734945297,
-0.032818883657455444,
0.027962103486061096,
0.09219283610582352,
0.024593312293291092,
0.21110817790031433,
-0.13081273436546326,
0.21490725874900818,
0.053693756461143494,
-0.12687048316001892,
-0.09432265162467957,
0.08915925770998001,
0.009897773154079914,
-0.06226309761404991,
-0.20037850737571716,
-0.025733232498168945,
-0.2749786674976349,
-0.32818999886512756,
-0.0012462963350117207,
0.12641938030719757,
0.08015266060829163,
0.3323690593242645,
-0.2549945116043091,
-0.09571804851293564,
0.09835628420114517,
0.20150741934776306,
-0.17995883524417877,
0.12313678115606308,
-0.32688793540000916,
-0.0013748554047197104,
-0.046573247760534286,
-0.04395722970366478,
-0.07095550000667572,
-0.22366556525230408,
0.08095683157444,
-0.05752839893102646,
-0.12691491842269897,
-0.29568150639533997,
0.010568235069513321,
0.060773324221372604,
-0.0709635317325592,
0.20533068478107452,
-0.12047850340604782,
0.22996921837329865,
0.10145311057567596,
0.10474513471126556,
0.02512465976178646,
0.048122141510248184,
-0.1044522151350975,
0.10023146867752075,
-0.08299356698989868,
0.29758360981941223,
0.29343459010124207,
-0.09035156667232513,
0.26371243596076965,
-0.11011502891778946,
-0.1943228542804718,
-0.1503509283065796,
0.07949408143758774,
0.15255680680274963,
0.09114746004343033,
-0.025981562212109566,
-0.2675248384475708,
0.032067716121673584,
-0.1817651242017746,
-0.2461368441581726,
-0.2190258502960205,
0.18899954855442047,
0.2013787031173706,
0.0028726288583129644,
-0.1415180116891861,
-0.09353600442409515,
-0.10904533416032791,
0.11396044492721558,
-0.12838096916675568,
0.05372775346040726,
0.17279857397079468,
0.33407285809516907,
-0.11013206094503403,
-0.03382870554924011,
-0.2788331210613251,
0.23460930585861206,
-0.16467317938804626,
0.016526969149708748,
-0.2584425210952759,
-0.13332700729370117,
-0.1894034892320633,
-0.11518334597349167,
-0.05645116791129112,
0.049804143607616425,
0.13040423393249512,
0.4109483063220978,
0.06666726619005203,
0.39655986428260803,
0.15212321281433105,
0.057002194225788116,
0.18279790878295898,
0.12247762084007263,
0.08245505392551422,
0.007912999019026756,
-0.12721450626850128,
0.19965390861034393,
-0.3274368643760681,
0.1541828215122223,
0.12085124105215073,
0.06348307430744171,
-0.09175495058298111,
0.04228615015745163,
0.0775981992483139,
-0.16894352436065674,
-0.10260672122240067,
0.04580888897180557,
-0.15164822340011597,
0.13811424374580383,
-0.16079860925674438,
-0.07782655209302902,
0.32444751262664795,
0.17141053080558777,
0.00269707920961082,
-0.11370518058538437,
-0.15135759115219116,
0.04982031509280205,
0.2242109775543213,
-0.0989479124546051,
-0.037820905447006226,
0.03601660951972008,
-0.06977728754281998,
0.31606999039649963,
0.049963273108005524,
-0.055801961570978165,
0.13843859732151031,
0.12321276217699051,
0.04308402165770531,
0.005292999092489481,
-0.0031359244603663683,
-0.12103363871574402,
-0.2671491503715515,
0.14072062075138092,
0.28084179759025574,
-0.018854577094316483,
0.14258551597595215,
0.06335806101560593,
0.17669600248336792,
0.010613259859383106,
-0.06439261883497238,
0.03575617074966431,
-0.2964150607585907,
-0.02727234922349453,
-0.12602998316287994,
0.25795668363571167,
0.14958511292934418,
0.17617030441761017,
0.052303723990917206,
0.12577898800373077,
-0.046899888664484024,
0.018956558778882027,
0.04569548740983009,
0.1750994175672531,
-0.12427202612161636,
0.2055981606245041,
-0.21756739914417267,
-0.21041837334632874,
0.22299405932426453,
-0.13952243328094482,
0.20137988030910492,
0.03900450840592384,
-0.08908775448799133,
-0.11323966830968857,
0.04225391894578934,
-0.11358892172574997,
0.09695689380168915,
-0.14690731465816498,
0.09724045544862747,
-0.048101119697093964,
-0.14702847599983215,
-0.29586267471313477,
0.20770038664340973,
-0.2162712812423706,
0.047957029193639755,
-0.21812720596790314,
-0.0058957249857485294,
-0.033119287341833115,
-0.03773067519068718,
0.20202966034412384,
0.14131760597229004,
-0.08599787950515747,
-0.23941001296043396,
-0.12898527085781097,
-0.036741163581609726,
-0.013845115900039673,
0.13214842975139618,
-0.14406739175319672,
-0.007129465229809284,
0.1933264434337616,
-0.17119120061397552,
-0.07841554284095764,
0.16813337802886963,
0.1789826601743698,
-0.004987717606127262,
-0.08953357487916946,
-0.07901902496814728,
-0.05987445265054703,
-0.14437560737133026,
0.16619426012039185,
-0.004427739419043064,
-0.21923333406448364,
0.04418832063674927,
0.04945002868771553,
0.04156526178121567,
0.04319865629076958,
0.09666771441698074,
-0.07357799261808395,
0.1073981523513794,
0.20419783890247345,
-0.1585244983434677,
-0.42243191599845886,
-0.20262548327445984,
-0.13359278440475464,
0.15216511487960815,
0.05079532414674759,
-0.3586673140525818,
-0.19164668023586273,
0.05436733365058899,
0.16465365886688232,
-0.06970585137605667,
-0.1039714366197586,
0.11947637796401978,
0.05642782896757126,
-0.1473415642976761,
0.13491559028625488,
-0.05649286136031151,
0.13436025381088257,
0.05883834511041641,
-0.06877508014440536,
0.039116159081459045,
0.22541220486164093,
-0.021072739735245705,
-0.1775047928094864,
0.5175183415412903,
0.14844535291194916,
-0.1508210450410843,
0.23059794306755066,
0.10856537520885468,
0.03147310018539429,
0.014985205605626106,
0.1715795248746872,
0.07652916759252548,
-0.15685155987739563,
0.005439051892608404,
0.1708366572856903,
-0.2410450279712677,
0.13924339413642883,
0.11383118480443954,
-0.12253863364458084,
0.09425658732652664,
-0.12863312661647797,
-0.1572936624288559,
0.06190584599971771,
-0.02569977380335331,
0.1613050252199173,
0.06075816601514816,
0.07734555751085281,
-0.16308316588401794,
0.1832665354013443,
0.1909628063440323,
-0.16379296779632568,
0.0924631655216217,
-0.03674492985010147,
0.09360447525978088,
-0.08651509881019592,
-0.22268012166023254,
0.22203214466571808,
-0.15088297426700592,
0.053237300366163254,
0.09637829661369324,
0.019572841003537178,
0.12961891293525696,
0.15666475892066956,
0.27294689416885376,
-0.016856800764799118,
-0.031121529638767242,
0.026105321943759918,
0.08203472942113876,
-0.2311115264892578,
-0.2641819417476654,
0.053031325340270996,
0.15333274006843567,
-0.13569612801074982,
0.002795192878693342,
0.05562054365873337,
-0.14848698675632477,
-0.03395881876349449,
-0.2896759510040283,
0.010614804923534393,
-0.198595330119133,
0.06347976624965668,
-0.044449467211961746,
-0.19036605954170227,
-0.03070378676056862,
0.06135204806923866,
-0.25146225094795227,
-0.10690297186374664,
-0.12537993490695953,
0.03444458544254303,
-0.20611093938350677,
0.18399403989315033,
-0.17937040328979492,
0.06841554492712021,
0.14366938173770905,
-0.08212992548942566,
0.1913304179906845,
-0.27351444959640503,
0.022150201722979546,
0.0593673400580883,
-0.18271155655384064,
-0.06082800775766373,
0.006463051773607731,
-0.2832462191581726,
0.0266386978328228,
-0.008319777436554432,
0.20707327127456665,
0.30024704337120056,
-0.0693444013595581,
-0.0005071717314422131,
-0.17311976850032806,
0.05006655678153038,
0.2354806810617447,
-0.20326018333435059,
0.10385075211524963,
-0.16457729041576385,
-0.3058077394962311,
-0.06039776653051376,
-0.026967309415340424,
0.13322386145591736,
0.04014120250940323,
-0.011125357821583748,
-0.014712687581777573,
-0.24576933681964874,
0.2853282392024994,
-0.0513678602874279,
-0.2998403310775757,
0.07138682901859283,
0.09758318960666656,
0.17062996327877045,
0.23091118037700653,
0.15744782984256744,
0.1703936755657196,
0.11171717196702957,
-0.1095162034034729,
-0.20773160457611084,
-0.14913450181484222,
0.10647762566804886,
0.00992036983370781,
0.10279014706611633,
0.19176939129829407,
0.018943293020129204,
-0.1889876425266266,
-0.25313857197761536,
-0.09550400823354721,
-0.11197945475578308,
0.49180710315704346,
-0.3690590262413025,
-0.047751374542713165,
0.08262386173009872,
-0.06546133756637573,
0.20396997034549713,
-0.15484070777893066,
0.0107943806797266,
-0.04167120158672333,
0.16088029742240906,
0.007843253202736378,
-0.013023429550230503,
-0.23630617558956146,
0.363180011510849,
0.026007728651165962,
-0.2986025810241699,
0.02267204225063324,
-0.1224372386932373,
0.12806396186351776,
-0.023825587704777718,
0.40618082880973816,
0.32426831126213074,
-0.0940709263086319,
-0.06126297265291214,
-0.038878265768289566,
0.013483714312314987,
-0.0607222244143486,
-0.10096723586320877,
-0.06407880783081055,
0.3204096257686615,
0.115193672478199,
0.16271455585956573,
-0.10097072273492813,
0.11643344163894653,
0.20036961138248444,
-0.14017872512340546,
-0.09401806443929672,
-0.22569800913333893,
0.2031237781047821,
0.09970217943191528,
-0.023929353803396225,
-0.09541651606559753,
0.015052218921482563,
0.1790652722120285,
0.011702463962137699,
0.1612132489681244,
0.21241985261440277,
-0.11130721867084503,
0.19876812398433685,
-0.14844834804534912,
0.12058022618293762,
-0.16293004155158997,
-0.020710883662104607,
0.08027378469705582,
-0.07879111915826797,
0.009208750911056995,
-0.05919986590743065,
-0.5503917336463928,
0.286760151386261,
0.25630131363868713,
-0.24749790132045746,
-0.006640119943767786,
-0.009085710160434246,
-0.04535683989524841,
-0.1404171586036682,
-0.05113387107849121,
-0.06399901211261749,
-0.08643778413534164,
0.34610122442245483,
-0.2986471652984619,
0.13066411018371582,
0.10183467715978622,
-0.002802418079227209,
-0.021623121574521065,
-0.06628947705030441,
0.05953148007392883,
0.3010646402835846,
0.03614004701375961,
-0.11209374666213989,
0.22855614125728607,
-0.11459573358297348,
0.33389610052108765,
-0.06773833185434341,
-0.08084310591220856,
0.2602560520172119,
0.12888841331005096,
0.0553242564201355,
0.25023022294044495,
0.08731209486722946,
-0.06499866396188736,
-0.04683520644903183,
0.0454728938639164,
-0.000043678624933818355,
-0.06315024942159653,
0.07158929854631424,
0.14117662608623505,
-0.01770518720149994,
0.05778522416949272,
-0.2183469980955124,
-0.10494944453239441,
0.18384228646755219,
-0.07048550993204117,
-0.03489373251795769,
-0.16036269068717957,
-0.08569261431694031,
-0.21876659989356995,
-0.048423655331134796,
-0.07825344055891037,
0.13225111365318298,
-0.1564967930316925,
-0.10790467262268066,
0.06503796577453613,
-0.012929972261190414,
0.006124550476670265,
0.0076308646239340305,
-0.19646060466766357,
-0.09527384489774704,
-0.22393487393856049,
0.23938409984111786,
-0.016786081716418266,
-0.20405490696430206,
0.14976702630519867,
0.005043287295848131,
0.06697607040405273,
0.033999111503362656,
0.20759469270706177,
0.10965622216463089,
0.07432913035154343,
-0.10018691420555115,
-0.12343192100524902,
0.2658753991127014,
-0.021233029663562775,
0.31196829676628113,
0.07137290388345718,
0.20119351148605347,
-0.13220500946044922,
0.30048924684524536,
0.22939139604568481,
0.06609423458576202,
0.13961350917816162,
0.2482943832874298,
-0.012744985520839691,
0.2613171935081482,
0.11619648337364197,
-0.12707528471946716,
-0.07234583795070648,
-0.09550692141056061,
0.2489045262336731,
0.07230551540851593,
-0.06685475260019302,
0.17718097567558289,
-0.14473316073417664,
0.2169141173362732,
0.03425230458378792,
-0.03297772631049156,
0.01590590551495552,
0.2813609838485718,
0.18638868629932404,
-0.14718873798847198,
0.06384453922510147,
-0.20609478652477264,
-0.015348827466368675,
-0.05669068172574043,
0.3112107515335083,
-0.0559321828186512,
-0.11104652285575867,
0.0692969411611557,
0.08424917608499527,
-0.003163712564855814,
-0.08959934860467911,
0.33353421092033386,
0.25695738196372986,
-0.06217195466160774,
-0.14146536588668823,
-0.30737537145614624,
-0.14354215562343597,
-0.004984644241631031,
0.01457277312874794,
0.2444496601819992,
0.1959320455789566,
0.30709514021873474,
-0.03105851449072361,
0.06818696856498718,
0.015065495856106281,
-0.20379947125911713,
-0.06238414719700813,
0.18725210428237915,
0.22854472696781158,
-0.006746726576238871,
-0.17169126868247986,
0.0651131123304367,
0.24440161883831024,
-0.0536823496222496,
-0.013024473562836647,
-0.055984679609537125,
-0.2559405267238617,
-0.10244689881801605,
0.03634447976946831,
-0.10037945955991745,
0.13177436590194702,
0.3051736652851105,
-0.24918079376220703,
-0.2949114143848419,
0.05236302316188812,
0.06529579311609268,
0.15574932098388672,
-0.40033194422721863,
0.12340504676103592,
-0.3221011459827423,
-0.008921406231820583,
0.001750722760334611,
0.27217522263526917,
-0.17358838021755219,
0.10102473199367523,
0.07041561603546143,
-0.2557549774646759,
0.19720453023910522,
-0.09952519088983536,
0.03023175522685051,
0.056937579065561295,
-0.24174566566944122,
0.11070944368839264,
0.2558075189590454,
-0.023238927125930786,
-0.036450568586587906,
0.08334110677242279,
-0.20801736414432526,
0.023486178368330002,
-0.07623784989118576,
-0.06664533168077469,
-0.16124732792377472,
-0.1327269971370697,
0.12508432567119598,
0.18482214212417603,
0.2159419059753418,
-0.18292906880378723,
0.015009982511401176,
0.04054754227399826,
-0.0010525183752179146,
-0.11192306131124496,
-0.12681764364242554,
-0.002785629592835903,
0.23876403272151947,
0.24763448536396027,
0.0380275696516037,
0.04030103236436844,
-0.07120281457901001,
0.23491400480270386,
-0.20594623684883118,
-0.021316081285476685,
-0.440449982881546,
-0.1641642302274704,
-0.07304631173610687,
-0.02390899695456028,
0.12304605543613434,
0.22970686852931976,
0.19071531295776367,
-0.036264482885599136,
0.14804694056510925,
0.04489772021770477,
0.0539633184671402,
-0.1585582047700882,
0.13501206040382385,
0.10763261467218399,
0.02683337777853012,
-0.05179924890398979,
-0.08733675628900528,
0.04475076124072075,
-0.06255186349153519,
0.00708277290686965,
0.27125632762908936,
-0.1128941997885704,
-0.41514939069747925,
-0.17472919821739197,
-0.26259320974349976,
-0.12078748643398285,
0.08810198307037354,
0.03470601513981819,
-0.23039086163043976,
-0.001852275338023901,
-0.18946748971939087,
0.2133830487728119,
-0.15753087401390076,
0.0989241749048233,
-0.07021374255418777,
0.04081730544567108,
-0.19297657907009125,
0.42224299907684326,
0.0035360173787921667,
-0.12673327326774597,
0.11530975252389908,
-0.03365287929773331,
-0.017099611461162567,
-0.0989697054028511,
0.06883414089679718,
-0.17174693942070007,
-0.053200118243694305,
-0.034715425223112106,
-0.3819223940372467,
0.051808666437864304,
-0.3328225910663605,
-0.0856245681643486,
-0.022430097684264183,
-0.15600663423538208,
0.09770043939352036,
0.02499506063759327,
-0.009699119254946709,
-0.00035459495848044753,
0.32654547691345215,
-0.04529207944869995,
0.21711035072803497,
-0.07763566821813583,
0.11626088619232178,
-0.07785848528146744,
-0.2614838778972626,
0.16193357110023499,
0.15204885601997375,
-0.32032960653305054,
0.05629351735115051,
0.06525484472513199,
-0.15272021293640137,
-0.06423745304346085,
-0.2694566249847412,
-0.13037993013858795,
0.004328777082264423,
0.17404475808143616,
-0.14373494684696198,
-0.0027804195415228605,
-0.24058282375335693,
-0.15241946280002594,
-0.09762228280305862,
0.07670138031244278,
0.13330920040607452,
-0.03025800734758377,
0.01389575470238924,
0.19205382466316223,
-0.054220251739025116,
0.09354647248983383,
-0.17500457167625427,
0.41858217120170593,
-0.15919601917266846,
-0.0030455305241048336,
0.058108557015657425,
0.07424046844244003,
0.2158735692501068,
-0.16988953948020935,
-0.25959429144859314,
-0.056605301797389984,
0.009175349026918411,
-0.047131020575761795,
0.17737233638763428,
0.017462145537137985,
-0.5359250903129578,
0.02044731192290783,
-0.06683553755283356,
-0.21429526805877686,
0.2043275386095047,
0.2360711395740509,
0.15592363476753235
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. distraction osteotomy (so-called Ilizarov procedure) performed on the normal (shorter) limbs. Readers are referred to a review and conference report for more details on this complex issue .The skeletal overgrowth of PS can result in significant biomechanical and functional compromise. Because of this, ongoing and comprehensive rehabilitation medicine care, including physical and occupational therapy, is important for many individuals. In addition, many individuals with PS develop substantial needs for custom-designed footwear or orthotics due to leg-length inequality or plantar CCTNs.Refer to an orthopedist if scoliosis is identified on clinical and/or radiographic examination. Scoliosis surgery is high-risk in individuals with PS. The authors are aware of individuals who have died from DVT and PE, with prophylactic anticoagulation. In spite of this risk, such surgery is indicated because the progressive nature of the scoliosis can lead to fatal restrictive lung disease. Scoliosis in individuals with PS can advance extremely rapidly, and attentive and frequent monitoring is | [
-0.17178836464881897,
-0.008208852261304855,
0.028380166739225388,
-0.29580581188201904,
0.10767733305692673,
-0.01675957255065441,
0.06477507203817368,
-0.22995920479297638,
-0.03685899078845978,
0.03507741540670395,
0.11273779720067978,
-0.14455413818359375,
0.06040484085679054,
-0.02726585790514946,
-0.4223039746284485,
0.3040754795074463,
-0.08414171636104584,
-0.005930925253778696,
0.1074071079492569,
0.18256156146526337,
-0.04284513741731644,
-0.2198016196489334,
-0.06203427538275719,
0.17540563642978668,
0.11214075982570648,
-0.0003656887565739453,
0.2117738574743271,
-0.038375962525606155,
-0.050723202526569366,
-0.3612557351589203,
-0.03225645422935486,
0.12783396244049072,
0.06915490329265594,
-0.14988571405410767,
0.14338622987270355,
-0.30587533116340637,
-0.260240763425827,
0.061454109847545624,
0.07770512998104095,
0.24205230176448822,
-0.04352454096078873,
-0.15282849967479706,
0.023409878835082054,
-0.15371280908584595,
0.16119131445884705,
0.21390213072299957,
0.32708340883255005,
0.01827436313033104,
-0.09632211178541183,
0.26726892590522766,
-0.2229779213666916,
0.0072700814343988895,
-0.015580479986965656,
-0.05450466275215149,
0.3516407310962677,
-0.16125549376010895,
0.1562773436307907,
-0.07262763381004333,
-0.2245110720396042,
0.10343918204307556,
0.30118778347969055,
0.15004774928092957,
0.038491327315568924,
-0.3816514313220978,
0.04293619841337204,
-0.07979726791381836,
-0.11204949021339417,
0.09931536018848419,
0.2607979476451874,
-0.017076143994927406,
0.3987564146518707,
-0.15830101072788239,
-0.09037015587091446,
0.14021655917167664,
0.1759728193283081,
-0.14357580244541168,
-0.05957389622926712,
-0.13164496421813965,
-0.025501323863863945,
-0.008395451121032238,
-0.14021708071231842,
-0.006227872334420681,
-0.03361095115542412,
0.020638056099414825,
-0.1497897356748581,
-0.09382759034633636,
-0.08942520618438721,
0.12310940027236938,
-0.07239481806755066,
-0.05391736701130867,
0.11048824340105057,
0.007707884535193443,
0.05847451090812683,
0.15130898356437683,
0.04851211979985237,
-0.10053718090057373,
0.14246763288974762,
0.08178866654634476,
0.019210334867239,
0.09486708790063858,
0.0359131284058094,
0.23372666537761688,
0.010928326286375523,
0.2862233817577362,
-0.06716803461313248,
-0.14178982377052307,
-0.11598676443099976,
-0.04555533453822136,
0.168585866689682,
-0.0786077231168747,
0.07977364212274551,
0.011353728361427784,
0.17189745604991913,
-0.15957611799240112,
-0.161951944231987,
-0.023117991164326668,
0.07401590049266815,
0.12846124172210693,
-0.11346907913684845,
-0.07587987929582596,
-0.010388213209807873,
-0.10991397500038147,
0.14172358810901642,
-0.23550614714622498,
0.12323585897684097,
0.0903410017490387,
0.2253226488828659,
-0.16753041744232178,
0.06756133586168289,
-0.30342474579811096,
0.2674906253814697,
-0.22847957909107208,
-0.2429325431585312,
-0.2548825740814209,
0.004971853457391262,
-0.08189388364553452,
-0.1566314846277237,
-0.2964423894882202,
-0.15191146731376648,
0.21780027449131012,
0.36205196380615234,
0.04262124001979828,
0.3063293993473053,
0.1819886416196823,
-0.003611629828810692,
0.14699459075927734,
0.18123602867126465,
0.08088087290525436,
0.08784573525190353,
-0.28426334261894226,
0.06819400191307068,
-0.18600596487522125,
0.09714445471763611,
-0.0538652278482914,
0.10203950107097626,
-0.2521425783634186,
-0.047540273517370224,
0.2889280915260315,
-0.2123853862285614,
0.03129372373223305,
-0.2150702178478241,
-0.3015037775039673,
-0.027286160737276077,
-0.08956305682659149,
-0.027690518647432327,
0.3225262761116028,
0.15731827914714813,
0.03967650234699249,
-0.15676379203796387,
-0.24715463817119598,
-0.093393474817276,
0.16552619636058807,
0.12210610508918762,
0.133747860789299,
-0.009313824586570263,
0.09867978096008301,
0.2757546305656433,
-0.02854144014418125,
-0.15202215313911438,
0.09630869328975677,
0.220106840133667,
-0.1410929560661316,
-0.06623778492212296,
-0.08146458864212036,
-0.1402236521244049,
-0.16421173512935638,
0.04735412821173668,
0.29179880023002625,
-0.024003837257623672,
0.15448631346225739,
0.06395573168992996,
0.017110787332057953,
0.016586102545261383,
0.05120553821325302,
-0.0645519569516182,
-0.19913968443870544,
0.06471813470125198,
-0.129088893532753,
0.2103717029094696,
0.04596569016575813,
-0.013070660643279552,
-0.0070732771418988705,
0.07178301364183426,
-0.001305295038037002,
0.04097181186079979,
0.10048510879278183,
0.16677001118659973,
-0.1937382072210312,
0.3202904760837555,
-0.2243122011423111,
-0.09602923691272736,
0.3708558976650238,
-0.37361228466033936,
0.019449422135949135,
-0.03472156822681427,
-0.0033214036375284195,
-0.019227877259254456,
-0.10032771527767181,
-0.30614200234413147,
-0.005475799553096294,
-0.23856595158576965,
0.19556978344917297,
-0.0993591696023941,
-0.16434812545776367,
-0.2740178406238556,
0.21738286316394806,
-0.08115563541650772,
-0.07360590994358063,
-0.03920232504606247,
0.010377653874456882,
0.023501994088292122,
0.07438639551401138,
0.12090770900249481,
0.0070818765088915825,
0.001220831647515297,
-0.320605605840683,
-0.12657424807548523,
0.12428776919841766,
-0.05763672664761543,
-0.09914998710155487,
-0.1377386748790741,
0.020403988659381866,
0.11098916083574295,
-0.17297261953353882,
-0.0668240487575531,
0.018055126070976257,
0.20389512181282043,
0.21879014372825623,
-0.1849413961172104,
-0.05912501737475395,
-0.08091258257627487,
-0.23973268270492554,
0.009937170892953873,
0.13181383907794952,
-0.2688855528831482,
-0.0037470159586519003,
0.11902394890785217,
-0.036207303404808044,
-0.0036253256257623434,
0.17664724588394165,
0.18742375075817108,
-0.00435691699385643,
0.3921215236186981,
-0.05557932332158089,
-0.40062078833580017,
-0.32979005575180054,
-0.10360896587371826,
0.1095484271645546,
0.10080933570861816,
-0.24114489555358887,
-0.19609183073043823,
0.04760455712676048,
0.24173210561275482,
0.03789474815130234,
-0.20922131836414337,
0.015995630994439125,
-0.11133535206317902,
0.0440632700920105,
0.09230274707078934,
0.1392124891281128,
0.13628235459327698,
0.15200576186180115,
-0.08918994665145874,
-0.07071226835250854,
0.2904832363128662,
0.026561109349131584,
-0.14487594366073608,
0.3039279580116272,
0.0722583755850792,
-0.06951753050088882,
0.1889953315258026,
0.1023406833410263,
-0.1243414431810379,
0.200283944606781,
0.2175845056772232,
0.20576320588588715,
-0.1163237988948822,
0.18232013285160065,
0.020516427233815193,
-0.18575017154216766,
0.24421942234039307,
0.14980486035346985,
-0.2466709166765213,
0.019845711067318916,
0.03380773961544037,
-0.20755799114704132,
0.21958141028881073,
0.04883797466754913,
0.17519257962703705,
-0.020462609827518463,
-0.024886691942811012,
0.12844352424144745,
0.021370837464928627,
0.2533775866031647,
-0.22662456333637238,
0.06306043267250061,
-0.07080269604921341,
0.025172159075737,
-0.0761997252702713,
-0.14764155447483063,
-0.04773469641804695,
-0.12381984293460846,
0.04800524190068245,
-0.05961036682128906,
0.026210762560367584,
-0.019505178555846214,
0.03284415230154991,
0.26097050309181213,
-0.0424438938498497,
0.012873012572526932,
0.055961303412914276,
0.14404718577861786,
-0.2695026099681854,
-0.021655309945344925,
0.010032548569142818,
0.009308301843702793,
-0.027376873418688774,
-0.13417214155197144,
0.05234195664525032,
-0.08538780361413956,
0.013757417909801006,
-0.15481314063072205,
-0.03279520198702812,
-0.22979173064231873,
0.09412363916635513,
0.11348626017570496,
-0.07536984980106354,
-0.0011151748476549983,
0.07689005881547928,
-0.14229384064674377,
0.015106767416000366,
-0.19859760999679565,
-0.04726081341505051,
-0.18092530965805054,
0.19244636595249176,
-0.11301455646753311,
-0.01617044024169445,
0.08265002816915512,
-0.015504604205489159,
0.07854890823364258,
-0.21815575659275055,
0.1286468654870987,
-0.03608526661992073,
-0.24324333667755127,
-0.18612705171108246,
0.09197504073381424,
-0.17367100715637207,
0.05789992958307266,
0.24225202202796936,
-0.002260801149532199,
0.3395964503288269,
0.13719969987869263,
-0.015179581940174103,
-0.04795880243182182,
-0.0309755839407444,
0.07781356573104858,
-0.11318650096654892,
0.08660762012004852,
-0.31241375207901,
-0.4122317433357239,
-0.05163389444351196,
0.059793196618556976,
0.17287836968898773,
0.0005142019363120198,
-0.04561790078878403,
-0.06999760121107101,
-0.23157373070716858,
0.2730260193347931,
-0.14562486112117767,
-0.18272265791893005,
0.2582177221775055,
0.017960475757718086,
0.1813386082649231,
0.06327907741069794,
0.14430685341358185,
0.08962427079677582,
0.1170649453997612,
-0.035273630172014236,
-0.1960342526435852,
-0.17227162420749664,
-0.12297158688306808,
-0.005894137546420097,
0.13997848331928253,
0.2878279983997345,
0.15451982617378235,
-0.16502873599529266,
-0.0794326663017273,
-0.1271834820508957,
-0.24310021102428436,
0.4913189113140106,
-0.323975145816803,
-0.10374926030635834,
0.11858298629522324,
-0.13826262950897217,
-0.03145771101117134,
0.023404305800795555,
-0.1410500854253769,
0.03546390309929848,
0.10382914543151855,
-0.027501292526721954,
0.0779942125082016,
-0.13456261157989502,
0.041482046246528625,
0.07352353632450104,
-0.37414905428886414,
0.1671278178691864,
-0.1552707701921463,
0.09522701054811478,
-0.05242194980382919,
0.28481605648994446,
0.1695319265127182,
-0.07204677909612656,
-0.0740918293595314,
0.17140637338161469,
0.022092977538704872,
0.06636858731508255,
-0.06218830868601799,
0.21889816224575043,
0.04493153840303421,
0.01700177974998951,
0.07338759303092957,
-0.06738617271184921,
0.3561936318874359,
0.19934670627117157,
-0.11963988095521927,
0.17968815565109253,
-0.11526581645011902,
0.1501207947731018,
0.08563736826181412,
0.028176529332995415,
-0.1260702759027481,
-0.03674810007214546,
0.04364551603794098,
-0.08681595325469971,
0.2840358316898346,
0.16370923817157745,
-0.17641997337341309,
0.09983538836240768,
-0.06959123909473419,
-0.0155051713809371,
-0.07359042763710022,
-0.19019316136837006,
0.007493786048144102,
-0.013178011402487755,
-0.2427099347114563,
0.035820696502923965,
-0.4151463210582733,
0.1031399667263031,
0.17030562460422516,
-0.04835905134677887,
-0.073430635035038,
-0.07301636040210724,
0.009763245470821857,
-0.0240046177059412,
-0.16954627633094788,
-0.20597872138023376,
0.09697576612234116,
0.11445188522338867,
-0.18699899315834045,
0.13905304670333862,
0.2978897988796234,
-0.021445823833346367,
0.06498336791992188,
-0.25766265392303467,
0.02524358592927456,
0.21606799960136414,
0.0452718548476696,
-0.033106207847595215,
0.18844391405582428,
0.042287301272153854,
0.20595452189445496,
-0.021181797608733177,
-0.09341747313737869,
0.45798227190971375,
0.10524839162826538,
-0.09899406135082245,
0.11229841411113739,
-0.09108143299818039,
-0.0609719380736351,
-0.05846278369426727,
0.1737530529499054,
0.0915166512131691,
-0.0020560412667691708,
-0.020595544949173927,
0.11984247714281082,
-0.013072626665234566,
0.09278233349323273,
-0.22355373203754425,
-0.21623466908931732,
0.15924447774887085,
0.01317363791167736,
0.07514913380146027,
-0.12987391650676727,
-0.11577365547418594,
0.0010155524360015988,
0.1225460097193718,
0.02410050295293331,
0.10388118028640747,
0.10915790498256683,
-0.08481527119874954,
0.3038482964038849,
0.011164710856974125,
0.14751611649990082,
0.0010073005687445402,
-0.13671539723873138,
-0.02552088163793087,
0.032805196940898895,
0.33541369438171387,
-0.17119383811950684,
-0.15027348697185516,
0.18030187487602234,
-0.0065926723182201385,
0.2265985757112503,
-0.01820671558380127,
0.14156895875930786,
0.03666505962610245,
-0.012221746146678925,
-0.05545404180884361,
-0.28981393575668335,
0.06285261362791061,
-0.061351533979177475,
0.1819201558828354,
0.183111771941185,
0.15752342343330383,
-0.07644527405500412,
0.33351385593414307,
0.13546514511108398,
0.10474041849374771,
0.1427084356546402,
0.2233169674873352,
0.22762919962406158,
0.09957171976566315,
0.10048314183950424,
-0.14959849417209625,
-0.11786918342113495,
0.04009746387600899,
0.14180216193199158,
0.05366315320134163,
-0.0113550815731287,
0.1766175627708435,
-0.20346565544605255,
0.08672431111335754,
0.05310463905334473,
-0.04432044178247452,
-0.010829105973243713,
0.21689441800117493,
0.34233808517456055,
-0.36421799659729004,
0.024526583030819893,
-0.3465021848678589,
-0.1513313502073288,
-0.10691659152507782,
0.338029146194458,
-0.025705251842737198,
-0.17519547045230865,
0.07392336428165436,
-0.09427856653928757,
-0.1542937308549881,
-0.2991292178630829,
0.21624645590782166,
0.19249919056892395,
-0.03651069477200508,
-0.254807710647583,
-0.23068363964557648,
-0.009188835509121418,
0.13611845672130585,
-0.02871052362024784,
0.299295037984848,
0.3163388967514038,
0.1213541254401207,
-0.11584489792585373,
-0.0014786175452172756,
0.007454582955688238,
-0.19598038494586945,
0.05195831507444382,
-0.09170389175415039,
0.12296541780233383,
-0.14618819952011108,
-0.20961607992649078,
0.04516037926077843,
0.034486375749111176,
-0.07769475132226944,
-0.16567657887935638,
-0.21617145836353302,
-0.07494411617517471,
0.06111567094922066,
0.06982013583183289,
-0.07754424214363098,
0.14370197057724,
0.08718854188919067,
-0.21537020802497864,
-0.09242446720600128,
0.028600234538316727,
0.13336247205734253,
0.08142238110303879,
-0.37265920639038086,
-0.06692688167095184,
-0.24916838109493256,
0.06569132208824158,
-0.11146847158670425,
0.526369571685791,
-0.1146811842918396,
0.2438514679670334,
-0.0035182442516088486,
-0.15326562523841858,
0.18240290880203247,
0.018993599340319633,
-0.03740028664469719,
0.005017201881855726,
-0.20820574462413788,
0.029772205278277397,
0.011155723594129086,
0.005461417604237795,
0.06117081269621849,
-0.020262066274881363,
-0.14488498866558075,
0.017569854855537415,
-0.10692232102155685,
0.09950894862413406,
-0.05627823621034622,
-0.2215270847082138,
0.1422242969274521,
-0.15883103013038635,
0.28455933928489685,
-0.30397090315818787,
0.1256183236837387,
-0.017801383510231972,
-0.11278311163187027,
0.06131488457322121,
-0.14866994321346283,
-0.02739325538277626,
0.2505798935890198,
0.3036912679672241,
-0.0098375603556633,
0.1088927835226059,
-0.05075542628765106,
0.3440706133842468,
-0.08696921169757843,
0.13211898505687714,
-0.16193684935569763,
0.09037921577692032,
0.00862494669854641,
-0.09937935322523117,
0.17476430535316467,
0.13695009052753448,
0.10091524571180344,
-0.016540667042136192,
0.06771835684776306,
-0.09012538939714432,
0.09787876158952713,
-0.3448535203933716,
0.15458382666110992,
0.07931595295667648,
-0.062487199902534485,
-0.1338457614183426,
-0.18815959990024567,
0.06854534149169922,
-0.07853949815034866,
-0.05723636969923973,
0.2234073281288147,
-0.08337283879518509,
-0.4028831422328949,
-0.11914052814245224,
-0.12754251062870026,
0.13186238706111908,
-0.14683763682842255,
-0.10763038694858551,
-0.2086266577243805,
0.04734402522444725,
-0.15792541205883026,
0.0989077240228653,
-0.1722247153520584,
0.19292005896568298,
0.04111402854323387,
-0.1155061200261116,
-0.1862546056509018,
0.3909497857093811,
-0.11855410039424896,
-0.15537208318710327,
-0.06876528263092041,
-0.03188133239746094,
0.04145137220621109,
-0.08304842561483383,
0.14777329564094543,
0.009982084855437279,
-0.13208356499671936,
-0.01559110265225172,
-0.10651364177465439,
0.29727280139923096,
-0.24037323892116547,
-0.05011128634214401,
0.00019389613589737564,
-0.2107289433479309,
0.09378492087125778,
0.01501729991286993,
0.1664639562368393,
-0.17247872054576874,
0.1567777693271637,
0.08097419887781143,
-0.010363235138356686,
-0.030351286754012108,
0.06673858314752579,
-0.15811051428318024,
-0.11975331604480743,
0.1496734470129013,
0.08141054958105087,
0.04454954341053963,
0.08112665265798569,
-0.02883630245923996,
-0.1336258351802826,
0.023081064224243164,
-0.4016493856906891,
-0.298611044883728,
0.2112455815076828,
0.009556994773447514,
0.044770747423172,
0.07356531172990799,
-0.25889262557029724,
-0.12628163397312164,
-0.18428026139736176,
-0.06324400007724762,
-0.09718653559684753,
-0.12297727167606354,
-0.036582909524440765,
0.11708161979913712,
0.05564470589160919,
0.02871723845601082,
-0.1253773272037506,
0.17158757150173187,
-0.09658075869083405,
-0.02421913482248783,
-0.11672183871269226,
0.06206544116139412,
-0.010412978939712048,
-0.12796860933303833,
-0.42406415939331055,
-0.3282470107078552,
-0.0675421953201294,
0.1272868514060974,
0.21816381812095642,
-0.05681237578392029,
-0.25475117564201355,
-0.07125963270664215,
0.020845722407102585,
-0.19694174826145172,
0.09340398013591766,
0.16348643600940704,
0.11022742837667465
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. due to leg-length inequality or plantar CCTNs.Refer to an orthopedist if scoliosis is identified on clinical and/or radiographic examination. Scoliosis surgery is high-risk in individuals with PS. The authors are aware of individuals who have died from DVT and PE, with prophylactic anticoagulation. In spite of this risk, such surgery is indicated because the progressive nature of the scoliosis can lead to fatal restrictive lung disease. Scoliosis in individuals with PS can advance extremely rapidly, and attentive and frequent monitoring is warranted .Cerebriform connective tissue nevi (CCTN). Individuals with PS who develop large plantar CCTNs should receive regular dermatologic care and attention to manage malodor (a potential complication of difficulty with cleanliness of the deepening of the sulci in late adolescence) and other concerns, such as pressure ulcerations. Large plantar CCTNs can also contribute to problems with shoe fit and often warrant pedorthic intervention as mentioned above. Surgical removal of a CCT | [
-0.07774423062801361,
0.07248630374670029,
0.05196961387991905,
-0.20309944450855255,
0.02260461077094078,
-0.07004987448453903,
-0.1258360594511032,
-0.17498493194580078,
-0.14366790652275085,
0.01090648490935564,
0.23594103753566742,
-0.03464001417160034,
0.10179565846920013,
-0.03766002878546715,
-0.32327380776405334,
0.19384457170963287,
-0.06728259474039078,
-0.04225938022136688,
-0.013026711530983448,
-0.011194676160812378,
-0.04343739151954651,
-0.18332745134830475,
-0.03901342302560806,
0.10906121879816055,
-0.01640869863331318,
-0.015862751752138138,
0.20584812760353088,
0.07361128181219101,
-0.027192655950784683,
-0.1185249611735344,
-0.04367629811167717,
0.020986927673220634,
0.04345354437828064,
-0.17653270065784454,
0.09806984663009644,
-0.2817372977733612,
-0.21431012451648712,
0.05442822724580765,
0.08867738395929337,
0.015895741060376167,
-0.015463504008948803,
-0.061746738851070404,
-0.11860944330692291,
-0.1256076544523239,
0.15504339337348938,
0.18922017514705658,
0.21049320697784424,
0.04361357539892197,
-0.08852560073137283,
0.20144110918045044,
-0.07296986132860184,
0.08274554461240768,
-0.041478075087070465,
0.007500004954636097,
0.12847024202346802,
-0.20001336932182312,
0.03126627579331398,
-0.08923519402742386,
-0.34798464179039,
0.19480113685131073,
0.3363824486732483,
0.10734593123197556,
0.12495751678943634,
-0.4120180606842041,
0.11693227291107178,
-0.057960767298936844,
-0.09109580516815186,
0.14068067073822021,
0.24949169158935547,
-0.0013125650584697723,
0.2830067276954651,
-0.17528487741947174,
-0.15325649082660675,
-0.007243730127811432,
-0.08576863259077072,
-0.15520678460597992,
0.10626471042633057,
0.024282105267047882,
-0.14311613142490387,
-0.26640087366104126,
-0.20969350636005402,
-0.16512928903102875,
-0.13221877813339233,
0.05947672203183174,
-0.29924893379211426,
-0.1543276011943817,
-0.08320457488298416,
0.09582618623971939,
0.011257313191890717,
0.08857833594083786,
0.18213964998722076,
-0.026772260665893555,
-0.05453934520483017,
0.17925593256950378,
-0.07244281470775604,
-0.06338302046060562,
0.1532362848520279,
0.017086774110794067,
0.011782691814005375,
0.05322454497218132,
0.023733092471957207,
0.234399676322937,
0.024572623893618584,
0.023562772199511528,
-0.0021115511190146208,
-0.08007961511611938,
-0.25098323822021484,
0.05165083706378937,
0.10159394145011902,
-0.1254590004682541,
-0.043690796941518784,
0.04684743657708168,
0.07135216146707535,
-0.04658643528819084,
-0.24009490013122559,
0.030270151793956757,
0.05023881793022156,
0.008005723357200623,
-0.11403986811637878,
-0.0904904305934906,
-0.04625028744339943,
-0.14596305787563324,
0.14523780345916748,
-0.11006401479244232,
0.11699514836072922,
0.05735952779650688,
0.15525679290294647,
-0.19718798995018005,
0.025763439014554024,
-0.19278991222381592,
0.21120145916938782,
-0.21666748821735382,
-0.11605444550514221,
-0.4172837436199188,
0.030061732977628708,
0.088187575340271,
-0.1733480542898178,
-0.23170675337314606,
-0.060233134776353836,
0.22253957390785217,
0.23229552805423737,
0.12188171595335007,
0.2747266888618469,
0.1823771595954895,
-0.07980002462863922,
0.11287090182304382,
0.20124056935310364,
0.0911417156457901,
0.1399896889925003,
-0.09152231365442276,
0.1615535169839859,
-0.08615345507860184,
0.20008686184883118,
0.02160518802702427,
0.11382552236318588,
-0.04370136186480522,
-0.07005370408296585,
0.2246171236038208,
-0.15619206428527832,
0.11145208775997162,
-0.1163799911737442,
-0.2948991060256958,
-0.06522982567548752,
-0.19020037353038788,
-0.04595990478992462,
0.2556290924549103,
0.14893387258052826,
-0.13166794180870056,
0.08444863557815552,
-0.14850306510925293,
-0.2052130401134491,
0.11436421424150467,
0.034726742655038834,
0.12583626806735992,
0.11223926395177841,
0.04580026492476463,
0.2608233392238617,
0.05390910804271698,
-0.13792726397514343,
0.20959851145744324,
0.16715946793556213,
-0.0665174275636673,
-0.11171344667673111,
-0.08582846075296402,
-0.026180913671851158,
-0.19609485566616058,
-0.03386148810386658,
0.23855137825012207,
-0.21764115989208221,
0.06483262777328491,
0.1735469400882721,
-0.02440953254699707,
-0.07033911347389221,
0.016098441556096077,
-0.03647983446717262,
-0.24038884043693542,
-0.04376212880015373,
-0.11957241594791412,
0.20458927750587463,
0.10977625846862793,
-0.03408607840538025,
-0.05526495352387428,
0.0637984648346901,
-0.10573326051235199,
0.0950368270277977,
0.06783515214920044,
0.11125296354293823,
-0.32475757598876953,
0.21569955348968506,
-0.03907322883605957,
0.01634940877556801,
0.4158259332180023,
-0.17548298835754395,
-0.11999727040529251,
0.0058186170645058155,
0.09848811477422714,
-0.10300808399915695,
0.01079865824431181,
-0.31835463643074036,
0.05980585142970085,
-0.2543618381023407,
0.20831814408302307,
-0.18568766117095947,
-0.14585284888744354,
-0.23149554431438446,
0.2619022727012634,
-0.0659361332654953,
-0.1074821799993515,
-0.06290049105882645,
0.065811388194561,
0.03936193138360977,
0.11263082176446915,
0.026912495493888855,
-0.04327206686139107,
0.1065022349357605,
-0.4446468651294708,
-0.14738288521766663,
0.2585849165916443,
-0.07547853142023087,
-0.11720079928636551,
-0.13732227683067322,
-0.006845610681921244,
0.0018184282816946507,
-0.18239760398864746,
-0.08392398059368134,
0.1036749854683876,
0.12494347244501114,
0.23883286118507385,
-0.2644633650779724,
-0.11666204780340195,
0.0478312224149704,
-0.2646108567714691,
0.10800058394670486,
0.0905417874455452,
-0.15570339560508728,
-0.03179502859711647,
0.14245475828647614,
-0.03016875870525837,
0.12285132706165314,
0.132207453250885,
0.20116259157657623,
0.09889979660511017,
0.4025091528892517,
-0.16051311790943146,
-0.2889900803565979,
-0.24323759973049164,
-0.15382467210292816,
0.10490772128105164,
-0.012646793387830257,
-0.21202825009822845,
-0.21328143775463104,
0.11194289475679398,
0.21486303210258484,
0.12213397026062012,
-0.0015469372738152742,
0.04448835551738739,
-0.0544046014547348,
0.09930742532014847,
0.16344478726387024,
0.1541452407836914,
0.15077632665634155,
0.043358031660318375,
-0.03247526288032532,
-0.03134125471115112,
0.31707534193992615,
-0.03857431933283806,
-0.20473261177539825,
0.1707196980714798,
0.06528077274560928,
0.03061050735414028,
0.048167336732149124,
0.12644712626934052,
-0.009416871704161167,
0.08943022787570953,
0.1842697113752365,
0.09650199860334396,
0.015969006344676018,
0.07277432084083557,
0.04597367346286774,
-0.03675265982747078,
0.14464791119098663,
0.14920592308044434,
-0.1879376620054245,
0.013438722118735313,
0.17326073348522186,
-0.2920974791049957,
0.315207839012146,
-0.03846520185470581,
0.04298700392246246,
-0.1292954981327057,
-0.0334869809448719,
0.16523750126361847,
-0.027273012325167656,
0.12178034335374832,
-0.10607850551605225,
-0.022230805829167366,
-0.02920803800225258,
0.04551621526479721,
0.08606915920972824,
-0.015610008500516415,
-0.03758852556347847,
-0.13501866161823273,
0.13088972866535187,
0.015607778914272785,
0.017631251364946365,
0.08694129437208176,
0.0223871860653162,
0.19964918494224548,
-0.16010397672653198,
-0.05167866870760918,
-0.0024683906231075525,
0.17811799049377441,
-0.2472708374261856,
-0.09893450140953064,
-0.003390686819329858,
-0.062886543571949,
0.034725289791822433,
-0.0979115441441536,
0.06467124819755554,
-0.11813780665397644,
-0.04158405214548111,
-0.17628957331180573,
-0.06164601072669029,
-0.2928357422351837,
0.003744392655789852,
0.14355811476707458,
0.07665739953517914,
0.03941241651773453,
-0.03366640582680702,
-0.14147844910621643,
-0.025290710851550102,
-0.15582720935344696,
-0.07670994102954865,
-0.2874930500984192,
0.183561772108078,
-0.08078835904598236,
-0.05850975215435028,
-0.014641201123595238,
0.057850588113069534,
0.13923309743404388,
-0.18941785395145416,
0.034759439527988434,
-0.1447950303554535,
-0.18657326698303223,
-0.016647985205054283,
0.012775077484548092,
-0.1714894324541092,
0.19634266197681427,
0.24323770403862,
0.002477730857208371,
0.35738447308540344,
0.03425726667046547,
0.10834736377000809,
-0.016216525807976723,
-0.08972309529781342,
0.03077906183898449,
-0.14031368494033813,
-0.05109959840774536,
-0.33483847975730896,
-0.2565934658050537,
-0.03333112224936485,
0.07347796112298965,
0.23424355685710907,
0.06230072304606438,
-0.14779071509838104,
-0.06473992019891739,
-0.22992350161075592,
0.18184787034988403,
-0.1719464808702469,
-0.11431635916233063,
0.254596471786499,
-0.0886073037981987,
0.17551812529563904,
0.14140988886356354,
-0.017915815114974976,
0.018824594095349312,
0.12671419978141785,
-0.05722364783287048,
-0.20854414999485016,
-0.14738669991493225,
-0.06766646355390549,
0.02153381146490574,
0.11560440808534622,
0.1489861160516739,
0.16896577179431915,
-0.17803581058979034,
-0.022220104932785034,
-0.020673001185059547,
-0.2549460232257843,
0.3972312808036804,
-0.24951134622097015,
-0.2951609492301941,
0.06562985479831696,
0.01806952804327011,
-0.04607933759689331,
0.05865601450204849,
-0.006117984186857939,
-0.032781798392534256,
0.12332545220851898,
-0.047209810465574265,
0.10636730492115021,
-0.10475955158472061,
-0.0030101267620921135,
-0.044349730014801025,
-0.31156590580940247,
0.13596342504024506,
-0.1167534738779068,
0.09844906628131866,
0.007332312408834696,
0.02914007008075714,
0.17233587801456451,
-0.037240125238895416,
-0.017673658207058907,
0.14033383131027222,
0.04707887023687363,
0.1148790717124939,
0.009079186245799065,
0.12911289930343628,
0.12407001107931137,
-0.08769164979457855,
0.18285724520683289,
-0.04382886737585068,
0.2692316770553589,
0.16732090711593628,
0.017007866874337196,
0.07716123759746552,
-0.10956120491027832,
0.17824426293373108,
0.07550686597824097,
-0.05734555050730705,
-0.09104309231042862,
-0.00950360856950283,
0.18546944856643677,
0.012938004918396473,
0.19309574365615845,
0.13495714962482452,
-0.13905563950538635,
-0.05332005023956299,
-0.11380233615636826,
0.01892172172665596,
-0.03397301211953163,
-0.09007535874843597,
0.13502386212348938,
-0.005346089135855436,
-0.14312389492988586,
0.11649401485919952,
-0.39745789766311646,
0.01719006709754467,
0.09076645970344543,
-0.033148251473903656,
-0.06170978397130966,
0.05608843266963959,
0.1329537183046341,
-0.032211415469646454,
-0.10950351506471634,
-0.1530872881412506,
0.031296223402023315,
-0.05350780487060547,
-0.05759420245885849,
0.04782259464263916,
0.18598130345344543,
0.0024387547746300697,
0.07181940227746964,
-0.15631350874900818,
0.12531264126300812,
0.11683196574449539,
0.12865275144577026,
0.040437545627355576,
0.23745886981487274,
-0.012725821696221828,
0.13003630936145782,
-0.0158071331679821,
-0.013401099480688572,
0.47299739718437195,
0.09373767673969269,
-0.07745096832513809,
-0.004650364629924297,
0.019108274951577187,
-0.017787791788578033,
-0.14399947226047516,
0.1399819701910019,
0.05674723908305168,
0.020257463678717613,
0.00010914279118878767,
0.07445202767848969,
-0.13755041360855103,
0.10987462848424911,
-0.2155868113040924,
-0.20951314270496368,
0.09638172388076782,
-0.05995067209005356,
0.1314450353384018,
-0.10468987375497818,
-0.22975896298885345,
0.1776774674654007,
0.11826207488775253,
-0.0026348663959652185,
0.12755225598812103,
0.08717119693756104,
-0.0867965891957283,
0.08090013265609741,
0.008595321327447891,
0.04476029798388481,
0.0030102485325187445,
-0.13553383946418762,
-0.06525834649801254,
0.10231566429138184,
0.1403474062681198,
-0.17246976494789124,
-0.09973825514316559,
-0.06756781786680222,
-0.17758828401565552,
0.2576538026332855,
-0.06588073074817657,
0.14201205968856812,
-0.07758830487728119,
0.022431498393416405,
-0.08211501687765121,
-0.2271651327610016,
0.14550504088401794,
-0.09546057879924774,
0.15299274027347565,
0.23492538928985596,
0.1626192033290863,
-0.03125334903597832,
0.1375323235988617,
0.16783392429351807,
0.09781720489263535,
0.10174944996833801,
0.2079746574163437,
0.12066789716482162,
-0.03116307035088539,
-0.04486318305134773,
-0.08235573023557663,
-0.07432949542999268,
-0.038646288216114044,
0.16567465662956238,
0.02151489071547985,
-0.10903102159500122,
0.21835219860076904,
-0.13205447793006897,
0.057428255677223206,
0.0002227233344456181,
0.003933211788535118,
0.07815171033143997,
0.19477644562721252,
0.2427644580602646,
-0.2670389413833618,
-0.025007475167512894,
-0.07536860555410385,
-0.06571413576602936,
-0.10509391874074936,
0.23741957545280457,
-0.13179050385951996,
-0.13883499801158905,
-0.0028957214672118425,
-0.19930008053779602,
-0.15844711661338806,
-0.26269227266311646,
0.24635063111782074,
0.22995038330554962,
-0.14064663648605347,
-0.16653139889240265,
-0.3028605580329895,
0.008314465172588825,
0.23450277745723724,
-0.07967714220285416,
0.15400604903697968,
0.3156968951225281,
0.11635968834161758,
-0.10989432781934738,
-0.1189456582069397,
0.10957188159227371,
-0.12456357479095459,
0.1689416766166687,
-0.06690298765897751,
0.14738298952579498,
-0.09458079189062119,
-0.0005497061647474766,
0.07393814623355865,
0.05973769724369049,
0.04821429029107094,
-0.16052408516407013,
-0.17927083373069763,
-0.038628287613391876,
0.02317487634718418,
0.09115300327539444,
-0.191458061337471,
0.054564546793699265,
0.03594514727592468,
-0.06442912667989731,
-0.07563881576061249,
0.09132470935583115,
0.04201299324631691,
0.09450600296258926,
-0.3114168345928192,
0.010312848724424839,
-0.11094371229410172,
0.05865589156746864,
-0.029122259467840195,
0.48329710960388184,
-0.04161318019032478,
0.15823894739151,
-0.1507200449705124,
-0.07756777852773666,
0.16354747116565704,
-0.008650925010442734,
-0.05768945440649986,
-0.025288760662078857,
-0.09259363263845444,
-0.010443149134516716,
-0.09109455347061157,
0.06458941102027893,
0.06823711842298508,
-0.047801848500967026,
-0.0602826289832592,
-0.05408336967229843,
-0.06340344250202179,
0.1348269134759903,
-0.06567686051130295,
-0.17711658775806427,
0.10011641681194305,
-0.10017948597669601,
0.2793813943862915,
-0.1953754425048828,
0.08860358595848083,
0.023080408573150635,
-0.171638622879982,
0.011184086091816425,
-0.13345199823379517,
0.014893482439219952,
0.11539729684591293,
0.13120268285274506,
-0.055845893919467926,
0.1606025993824005,
-0.06112360954284668,
0.2665002644062042,
-0.047612376511096954,
0.05506477877497673,
-0.14803586900234222,
0.042092446237802505,
-0.1239214837551117,
-0.15018881857395172,
0.16038908064365387,
0.1547972857952118,
0.04323386400938034,
-0.01266673393547535,
0.047137174755334854,
-0.21609815955162048,
-0.11108053475618362,
-0.3469123840332031,
0.20610257983207703,
0.09212590754032135,
-0.09314847737550735,
-0.06543365120887756,
-0.07447472959756851,
0.12412551790475845,
-0.25249552726745605,
-0.009014475159347057,
0.20669995248317719,
-0.08110281080007553,
-0.3503575921058655,
0.017158469185233116,
-0.16763678193092346,
0.11821027100086212,
-0.07429500669240952,
-0.15566152334213257,
-0.15077538788318634,
0.1218639612197876,
-0.1545911580324173,
0.04633180424571037,
-0.04880458116531372,
0.1382620632648468,
0.04852097108960152,
-0.1612708419561386,
-0.3055470287799835,
0.43825197219848633,
-0.04403470456600189,
-0.18735238909721375,
-0.15392854809761047,
0.013873129151761532,
-0.026361098513007164,
-0.037891265004873276,
0.0612880140542984,
0.0919104814529419,
-0.17185170948505402,
0.0106350127607584,
-0.07162898778915405,
0.11565854400396347,
-0.09284881502389908,
-0.0672633945941925,
-0.008795586414635181,
-0.17968793213367462,
0.12577347457408905,
-0.10435564070940018,
0.1098034456372261,
-0.14932101964950562,
0.035689663141965866,
-0.02173287235200405,
-0.05840062350034714,
-0.1001996099948883,
0.05712907016277313,
-0.020491447299718857,
-0.00652009854093194,
0.071269690990448,
0.09628260135650635,
0.20475201308727264,
-0.0853678435087204,
0.08832921832799911,
-0.15092340111732483,
-0.023161115124821663,
-0.29315271973609924,
-0.2237650752067566,
0.09591109305620193,
-0.19689367711544037,
0.0556131936609745,
0.07934166491031647,
-0.254032701253891,
-0.14308962225914001,
-0.16906243562698364,
0.023185180500149727,
-0.10800585895776749,
-0.11023379117250443,
0.020118260756134987,
0.12576843798160553,
-0.02505515143275261,
0.0666758269071579,
-0.08071893453598022,
0.0445229709148407,
-0.10229242593050003,
0.024921471253037453,
-0.03771530091762543,
0.1473115235567093,
0.007908958941698074,
-0.08339498192071915,
-0.3591693043708801,
-0.318156898021698,
-0.10747836530208588,
0.06490924954414368,
0.19709816575050354,
-0.08653969317674637,
-0.21619752049446106,
-0.033423542976379395,
0.1452139914035797,
-0.22207586467266083,
0.09892521053552628,
0.10350971668958664,
0.04286608844995499
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. tive and frequent monitoring is warranted .Cerebriform connective tissue nevi (CCTN). Individuals with PS who develop large plantar CCTNs should receive regular dermatologic care and attention to manage malodor (a potential complication of difficulty with cleanliness of the deepening of the sulci in late adolescence) and other concerns, such as pressure ulcerations. Large plantar CCTNs can also contribute to problems with shoe fit and often warrant pedorthic intervention as mentioned above. Surgical removal of a CCTN has been successfully accomplished in at least two individuals.Overgrowth of lipomatous tissue / lipoatrophy. Management of the overgrowth of adipose tissue is challenging because the areas of adipose overgrowth are not encapsulated and discrete (in contrast to lipomas) and, therefore, can be difficult to resect and commonly regrow after surgical debulking. The authors generally recommend open surgical approaches over liposuction because the highly vascularized lipomatous overgrowth in some individuals can | [
-0.022859884425997734,
0.15910691022872925,
0.08542779833078384,
-0.061516400426626205,
0.08837735652923584,
-0.03208654746413231,
-0.0794549286365509,
-0.21550679206848145,
-0.16665002703666687,
0.07843490689992905,
0.2527073621749878,
-0.012626323848962784,
0.12456320226192474,
0.05024828389286995,
-0.2734126150608063,
-0.003805861109867692,
-0.09893907606601715,
-0.11143490672111511,
-0.07587198168039322,
-0.07116355746984482,
0.07280928641557693,
-0.11979148536920547,
0.07979580760002136,
0.2536109685897827,
-0.03812296688556671,
0.011154714971780777,
0.23798111081123352,
0.3170328438282013,
0.013308818452060223,
0.04655793309211731,
-0.05738329142332077,
-0.013802610337734222,
0.11138510704040527,
-0.21675163507461548,
0.08484262228012085,
-0.19895417988300323,
-0.09356608986854553,
-0.00562921492382884,
0.09108675271272659,
-0.07630986720323563,
-0.0008008573204278946,
0.07124239206314087,
-0.08332093060016632,
-0.02447422966361046,
0.24327659606933594,
-0.0448024645447731,
0.07673797011375427,
0.11995185911655426,
-0.0480831079185009,
0.1939862072467804,
0.11005271971225739,
-0.04585612937808037,
0.13077500462532043,
0.056716419756412506,
0.22870688140392303,
-0.13148321211338043,
-0.02362111769616604,
-0.004966115579009056,
-0.3201565444469452,
0.0462544746696949,
0.19856417179107666,
0.03725063428282738,
0.08397527039051056,
-0.3499404788017273,
0.1469108909368515,
0.001853819820098579,
-0.2444940060377121,
0.04979555681347847,
0.19229941070079803,
0.0027395961806178093,
0.27639999985694885,
-0.16111569106578827,
-0.13708558678627014,
-0.10224933922290802,
-0.12491755187511444,
-0.19852887094020844,
0.17413991689682007,
-0.060711104422807693,
-0.23060563206672668,
-0.3347671329975128,
-0.06299307197332382,
-0.2309531420469284,
-0.16002149879932404,
0.15304797887802124,
-0.1661251187324524,
-0.05658385902643204,
-0.026511482894420624,
0.1129407212138176,
0.023689936846494675,
-0.017918774858117104,
0.08693423867225647,
0.022745687514543533,
-0.04107898846268654,
0.1766163408756256,
-0.15137846767902374,
-0.14634433388710022,
0.011885480023920536,
-0.31648051738739014,
-0.013661917299032211,
0.003854812355712056,
0.20193694531917572,
0.14630702137947083,
0.016871213912963867,
-0.06964720040559769,
0.043194614350795746,
-0.05952120199799538,
-0.19845643639564514,
0.13321125507354736,
0.021995553746819496,
-0.05265573784708977,
-0.09182588011026382,
-0.1384536772966385,
-0.024531204253435135,
0.012450366280972958,
-0.29464757442474365,
-0.05952782183885574,
0.08848327398300171,
0.043915651738643646,
0.038701970130205154,
-0.10605558007955551,
0.05545955151319504,
-0.09606298804283142,
0.14796456694602966,
0.13079188764095306,
0.11958102136850357,
-0.001213451032526791,
0.2345467358827591,
-0.12454859167337418,
0.03842700272798538,
-0.10465697944164276,
0.08669828623533249,
-0.17951932549476624,
-0.049932852387428284,
-0.27797043323516846,
-0.11404740810394287,
0.13952358067035675,
-0.14103248715400696,
0.03220032900571823,
0.08829539269208908,
0.014125489629805088,
0.3022603988647461,
0.13884542882442474,
0.4464668333530426,
0.11292419582605362,
-0.13810612261295319,
0.03671129420399666,
0.13301070034503937,
0.12356194853782654,
0.13238471746444702,
-0.02662905678153038,
0.1940755546092987,
-0.010347285307943821,
0.2040991634130478,
0.046448495239019394,
0.07812319695949554,
0.09669193625450134,
-0.10683821886777878,
0.04629439488053322,
-0.12143012881278992,
-0.1478058099746704,
0.01242915540933609,
-0.21873363852500916,
0.01763003133237362,
-0.1351887285709381,
-0.04284345358610153,
0.30499589443206787,
-0.09277016669511795,
-0.09673238545656204,
0.19748060405254364,
0.08614173531532288,
-0.16442309319972992,
0.0695437490940094,
-0.1998899281024933,
0.13599814474582672,
-0.029475068673491478,
-0.041520338505506516,
0.1609904170036316,
0.044651638716459274,
0.0036881286650896072,
0.07961716502904892,
0.10723886638879776,
-0.03186609223484993,
0.01744956150650978,
-0.06713557988405228,
0.028496604412794113,
-0.21019525825977325,
-0.027593562379479408,
0.2783692479133606,
-0.12707754969596863,
0.047493163496255875,
0.2999206483364105,
-0.05767224729061127,
-0.15002289414405823,
-0.10621297359466553,
0.02762671746313572,
-0.2475777417421341,
-0.05016161501407623,
-0.1043391302227974,
0.22549423575401306,
0.2810467481613159,
-0.03222081810235977,
-0.04597344994544983,
0.16140194237232208,
0.025172175839543343,
0.09147129207849503,
0.07384493201971054,
0.043754417449235916,
-0.21658922731876373,
0.07660675048828125,
-0.010676712729036808,
-0.055176470428705215,
0.1461866796016693,
0.030375458300113678,
0.0028552410658448935,
0.004674348048865795,
0.07017021626234055,
-0.07208006083965302,
0.03862258046865463,
-0.1163630560040474,
0.12719547748565674,
-0.16888940334320068,
0.26179662346839905,
-0.04698359966278076,
-0.16119210422039032,
-0.29945266246795654,
0.12219779938459396,
-0.17853312194347382,
-0.09988967329263687,
-0.12185491621494293,
0.0905781239271164,
0.04063727706670761,
-0.07088515907526016,
0.015587616711854935,
-0.021177716553211212,
0.03961940109729767,
-0.24042271077632904,
-0.05417167395353317,
0.1663368046283722,
-0.14870542287826538,
0.12628905475139618,
-0.2638218104839325,
0.12771131098270416,
-0.0031573185697197914,
-0.24849486351013184,
-0.00630834698677063,
0.0670149028301239,
0.1891179233789444,
0.07515480369329453,
-0.13216887414455414,
-0.2278681844472885,
0.06731006503105164,
-0.19767725467681885,
0.3078061044216156,
-0.05308869853615761,
-0.14454136788845062,
-0.020688334479928017,
0.032059263437986374,
-0.12068822979927063,
-0.01165458932518959,
0.1749749630689621,
0.0004925061366520822,
0.010795687325298786,
0.13773809373378754,
-0.06391120702028275,
-0.11757509410381317,
-0.2372848093509674,
-0.11373281478881836,
0.14569596946239471,
-0.06590959429740906,
-0.2959793508052826,
-0.2674568295478821,
0.19834090769290924,
0.18281380832195282,
0.06001969426870346,
0.14941760897636414,
0.11028602719306946,
0.008589503355324268,
0.1435946226119995,
0.2822977304458618,
-0.08282062411308289,
0.11275851726531982,
-0.010543692857027054,
0.0342811681330204,
-0.031997911632061005,
0.33719152212142944,
0.03806259483098984,
-0.22204044461250305,
0.28389716148376465,
0.09691361337900162,
0.007888075895607471,
0.06053265556693077,
-0.010713224299252033,
0.06716063618659973,
-0.022345351055264473,
0.03162630274891853,
0.04270557686686516,
-0.008821981959044933,
0.08783590793609619,
0.21908605098724365,
0.00978837814182043,
-0.015702536329627037,
0.22969698905944824,
-0.08957857638597488,
0.0752759650349617,
0.25033169984817505,
-0.14649324119091034,
0.2350911945104599,
-0.06559690088033676,
-0.008268844336271286,
-0.14547710120677948,
-0.01839948259294033,
0.058298368006944656,
0.06215206906199455,
-0.07470885664224625,
0.006249196361750364,
-0.05246612802147865,
0.040918901562690735,
0.11412663012742996,
0.12292726337909698,
0.07087314873933792,
0.061444006860256195,
0.011539316736161709,
0.0030575315468013287,
0.07844893634319305,
0.04000742360949516,
0.11056084930896759,
0.04474934563040733,
0.08149740844964981,
-0.06525406241416931,
-0.036501944065093994,
0.03623856604099274,
0.05404333770275116,
-0.2209937423467636,
-0.271336168050766,
-0.007525963243097067,
-0.02603783644735813,
0.008854401297867298,
-0.1730821430683136,
0.0413583479821682,
-0.1330406218767166,
-0.12096082419157028,
-0.23079107701778412,
-0.06606881320476532,
-0.1918777972459793,
-0.05792922526597977,
0.06935397535562515,
0.10356000810861588,
-0.15232230722904205,
0.026160690933465958,
-0.2043120265007019,
-0.11862413585186005,
-0.055071450769901276,
0.01196192391216755,
-0.2679113745689392,
0.11675379425287247,
0.07469207793474197,
-0.029231736436486244,
0.1642799824476242,
-0.012120713479816914,
0.10277525335550308,
-0.05145277827978134,
-0.03757743164896965,
-0.18347950279712677,
-0.1472601294517517,
-0.05330813303589821,
-0.0064320978708565235,
-0.1742493212223053,
0.07127737253904343,
0.0692068561911583,
-0.03796747326850891,
0.24075475335121155,
0.017930304631590843,
0.15535752475261688,
-0.012831918895244598,
-0.0687381848692894,
0.04675215855240822,
-0.16118672490119934,
-0.03549497202038765,
-0.17066971957683563,
-0.22533318400382996,
-0.08196473121643066,
0.25319334864616394,
0.10650736093521118,
0.04301956668496132,
-0.21617525815963745,
-0.0040986607782542706,
-0.1877157837152481,
0.043135326355695724,
-0.07224936038255692,
-0.2059662640094757,
0.016269994899630547,
-0.1283566802740097,
0.026533478870987892,
0.3139801323413849,
0.01231450866907835,
0.06547554582357407,
0.11313974112272263,
-0.07030055671930313,
-0.21778272092342377,
0.024115921929478645,
-0.09125296026468277,
0.09539017826318741,
0.10822436213493347,
0.20081202685832977,
0.13596375286579132,
-0.14116626977920532,
-0.13838177919387817,
0.023569177836179733,
-0.18118338286876678,
0.24410778284072876,
-0.24261777102947235,
-0.10601471364498138,
-0.09263086318969727,
-0.049022749066352844,
-0.1565365344285965,
-0.08736233413219452,
0.09552065283060074,
0.17677178978919983,
0.08475116640329361,
-0.010167407803237438,
0.03427133709192276,
-0.0942799374461174,
0.2671186923980713,
-0.036531973630189896,
-0.17910850048065186,
0.14069810509681702,
-0.06365913152694702,
0.18792147934436798,
0.06780413538217545,
0.07810569554567337,
0.311784029006958,
-0.09116742759943008,
-0.09784038364887238,
0.03736269846558571,
0.08838219940662384,
0.018417268991470337,
0.1495228111743927,
0.11154421418905258,
0.22730453312397003,
-0.06414458155632019,
0.2964005768299103,
0.09860531985759735,
0.09110086411237717,
0.21534503996372223,
-0.11546781659126282,
0.12047801166772842,
-0.04604107886552811,
0.08430372923612595,
0.021596824750304222,
-0.0671338140964508,
-0.1116449311375618,
-0.00582331046462059,
0.25361377000808716,
-0.05396748334169388,
0.22312934696674347,
0.17053945362567902,
-0.1869138926267624,
0.026906011626124382,
-0.09826046973466873,
0.05203769728541374,
0.10745150595903397,
0.15740515291690826,
0.10372545570135117,
0.017161119729280472,
0.006771882995963097,
0.07541809231042862,
-0.3233239948749542,
0.017119133844971657,
0.014793427661061287,
-0.13679470121860504,
-0.019943835213780403,
-0.004623089917004108,
-0.0006389014306478202,
-0.09194651991128922,
-0.010365026071667671,
0.05837932974100113,
-0.01820378191769123,
0.01103728637099266,
-0.06534174084663391,
0.030249692499637604,
0.0652037262916565,
0.05237723886966705,
-0.017043456435203552,
-0.10066933184862137,
0.06251370161771774,
0.054293159395456314,
0.0816240906715393,
-0.04201558977365494,
0.29872432351112366,
-0.14107772707939148,
0.01899166963994503,
-0.0837564468383789,
0.008416717872023582,
0.3557504117488861,
0.044580526649951935,
0.05737790837883949,
-0.05571712926030159,
0.08750434219837189,
-0.1613827645778656,
-0.16454489529132843,
0.18304188549518585,
0.12351645529270172,
0.08034290373325348,
0.0426195003092289,
0.09981123358011246,
-0.20178166031837463,
0.14276450872421265,
-0.2667374610900879,
-0.04026719927787781,
0.08454346656799316,
-0.09113138914108276,
-0.05130044370889664,
0.03141044080257416,
-0.12312708050012589,
0.07722682505846024,
-0.17679855227470398,
-0.07926423847675323,
0.06677217781543732,
0.023323874920606613,
-0.09301869571208954,
-0.060082823038101196,
-0.05287715792655945,
-0.02708044834434986,
0.15627586841583252,
-0.04347307235002518,
0.026652630418539047,
-0.10489276796579361,
0.1498129516839981,
-0.0336931087076664,
-0.13029544055461884,
-0.10227945446968079,
-0.04609086364507675,
0.14729748666286469,
0.014431153424084187,
-0.032337892800569534,
0.09489212930202484,
-0.0009745766292326152,
-0.018966853618621826,
-0.07419293373823166,
0.058355312794446945,
-0.04254970699548721,
0.12233881652355194,
0.2146378457546234,
0.11593594402074814,
-0.0654165968298912,
0.08295276015996933,
0.06598217040300369,
-0.03312331438064575,
-0.014788168482482433,
0.2267494946718216,
-0.025314409285783768,
-0.06483030319213867,
-0.295637309551239,
-0.07093450427055359,
-0.1819978952407837,
-0.1264875829219818,
0.18850581347942352,
0.10307564586400986,
-0.20114511251449585,
0.2582587003707886,
-0.019848154857754707,
0.09317284822463989,
-0.034396082162857056,
-0.025205517187714577,
0.16983871161937714,
0.19313041865825653,
0.22198516130447388,
-0.06940299272537231,
0.11621242016553879,
-0.07324068248271942,
-0.04239394888281822,
-0.10993116348981857,
0.16978545486927032,
-0.17047123610973358,
-0.2867741286754608,
0.01904040016233921,
-0.1404184252023697,
-0.10033156722784042,
-0.24784506857395172,
0.11883910745382309,
0.09121061116456985,
-0.2709706425666809,
-0.14838719367980957,
-0.1633630245923996,
-0.056791309267282486,
0.2526095509529114,
0.05134384334087372,
0.10172101110219955,
0.26955923438072205,
0.21794100105762482,
0.021405283361673355,
-0.08474959433078766,
0.034750740975141525,
-0.0009368601604364812,
0.1656319946050644,
0.06258717179298401,
0.048744697123765945,
-0.10532092303037643,
0.20096534490585327,
0.03353594243526459,
0.050951991230249405,
0.07199545204639435,
-0.1484440565109253,
-0.1134369745850563,
-0.0299978069961071,
0.05972918123006821,
0.18082650005817413,
-0.3156830370426178,
-0.049183063209056854,
0.0777009129524231,
-0.05938349664211273,
-0.23564212024211884,
0.05158507451415062,
-0.01624138280749321,
0.2053270936012268,
-0.14404736459255219,
0.15404091775417328,
-0.11443785578012466,
0.06671769917011261,
0.02627481333911419,
0.0876133069396019,
-0.22842270135879517,
0.12629522383213043,
-0.1165485605597496,
-0.09707114100456238,
0.019127365201711655,
-0.07947897166013718,
0.037346597760915756,
0.1644357293844223,
0.03228696435689926,
0.09073592722415924,
0.01994434930384159,
0.03580174595117569,
0.1056608110666275,
0.09190307557582855,
-0.041683994233608246,
0.02419966645538807,
-0.11465636640787125,
0.04513285309076309,
-0.05683662369847298,
0.16480937600135803,
0.07409942895174026,
0.12086659669876099,
0.1745395064353943,
-0.09990473091602325,
0.12447106093168259,
-0.01767779141664505,
-0.09535010904073715,
-0.05537768080830574,
-0.22280754148960114,
0.011605942621827126,
0.1435002088546753,
0.029929451644420624,
-0.04452237859368324,
0.0821755975484848,
-0.09989635646343231,
0.12101443111896515,
-0.10681574791669846,
-0.1367821991443634,
-0.13146576285362244,
-0.13763171434402466,
-0.2755589783191681,
-0.19615471363067627,
0.030472414568066597,
0.11273803561925888,
0.07628657668828964,
-0.026285968720912933,
0.016506070271134377,
-0.1858132928609848,
-0.18307560682296753,
-0.3120766878128052,
0.08606921136379242,
0.07919710874557495,
0.026697538793087006,
-0.13069556653499603,
0.06988932937383652,
0.03965524584054947,
-0.2613682746887207,
-0.031145421788096428,
0.3297360837459564,
-0.1548919826745987,
-0.2946707308292389,
-0.24579410254955292,
-0.25304514169692993,
0.06198781356215477,
-0.060288794338703156,
-0.009358587674796581,
0.06553200632333755,
0.10338333994150162,
-0.1544899046421051,
-0.05940229073166847,
-0.10331986844539642,
0.15586981177330017,
-0.011658305302262306,
-0.13304546475410461,
-0.20063844323158264,
0.2658279240131378,
0.1541176587343216,
-0.14169175922870636,
-0.0434618704020977,
0.02757342718541622,
-0.01094864308834076,
-0.09029484540224075,
-0.015546830371022224,
0.21040578186511993,
-0.13406743109226227,
0.1460866928100586,
-0.21872200071811676,
-0.02299085445702076,
-0.15132072567939758,
-0.0603371188044548,
-0.10464299470186234,
-0.15405042469501495,
0.10045843571424484,
0.018397623673081398,
-0.017425840720534325,
-0.08439116179943085,
-0.039138782769441605,
-0.09726128727197647,
0.06579234451055527,
-0.06770114600658417,
-0.10005652904510498,
0.03021865338087082,
-0.08467205613851547,
0.18818126618862152,
0.10530683398246765,
0.06099328771233559,
-0.06349268555641174,
0.2895442247390747,
-0.00037327330210246146,
-0.07227340340614319,
-0.2092539668083191,
-0.20647642016410828,
0.0994267389178276,
-0.06070537492632866,
0.015069443732500076,
-0.06265247613191605,
-0.0569368377327919,
-0.2367958128452301,
-0.10742530226707458,
0.13212108612060547,
-0.03130630776286125,
-0.18207098543643951,
0.13111580908298492,
0.17216546833515167,
-0.07797075808048248,
0.037637997418642044,
-0.011821165680885315,
-0.058815065771341324,
-0.10336955636739731,
0.11185762286186218,
-0.0067572686821222305,
0.05049017816781998,
0.0703052282333374,
-0.1157371997833252,
-0.10349495708942413,
-0.21178384125232697,
-0.1101611778140068,
-0.12807606160640717,
0.17054308950901031,
-0.1201048418879509,
-0.22333869338035583,
0.14136792719364166,
0.2169300615787506,
-0.13767369091510773,
0.15889416635036469,
-0.03900090977549553,
0.010121109895408154
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. Surgical removal of a CCTN has been successfully accomplished in at least two individuals.Overgrowth of lipomatous tissue / lipoatrophy. Management of the overgrowth of adipose tissue is challenging because the areas of adipose overgrowth are not encapsulated and discrete (in contrast to lipomas) and, therefore, can be difficult to resect and commonly regrow after surgical debulking. The authors generally recommend open surgical approaches over liposuction because the highly vascularized lipomatous overgrowth in some individuals can result in difficult-to-control hemorrhaging and/or chronically weeping lymphatics.Deep vein thrombosis (DVT) and pulmonary embolism (PE). The authors recommend emergent evaluation of individuals who develop symptoms of DVT (e.g., palpable subcutaneous rope-like mass, swelling, erythema, pain, and distal venous congestion) or PE (e.g., shortness of breath, chest pain, and cough which may include hemoptysis). Because individuals | [
-0.13061006367206573,
0.03979278728365898,
-0.04348171502351761,
-0.05589114874601364,
0.13825896382331848,
0.1519426554441452,
-0.05972479656338692,
-0.04940013587474823,
-0.12097695469856262,
-0.007326302584260702,
0.2300073504447937,
-0.07798643410205841,
0.26667603850364685,
0.04187779873609543,
-0.030065195634961128,
0.13729451596736908,
-0.23407575488090515,
-0.08440711349248886,
0.11385764926671982,
-0.02580096758902073,
-0.015295930206775665,
-0.05908733978867531,
0.046907901763916016,
0.21328435838222504,
-0.006967253517359495,
-0.0491444393992424,
0.1977405697107315,
0.1773284673690796,
0.012515416368842125,
0.14643508195877075,
-0.019076770171523094,
0.14218974113464355,
0.13928797841072083,
-0.20723487436771393,
0.011242569424211979,
-0.11512497067451477,
-0.016000932082533836,
0.034355513751506805,
0.2044108361005783,
0.02570190466940403,
-0.09703341126441956,
0.09077665954828262,
-0.03031068854033947,
-0.009592551738023758,
0.04485899209976196,
-0.09605123102664948,
0.2080203890800476,
0.13506074249744415,
-0.16505466401576996,
0.3184834122657776,
0.11720483750104904,
-0.041378721594810486,
0.2647338807582855,
-0.11031525582075119,
0.23004278540611267,
-0.05227192863821983,
0.035546012222766876,
-0.040223993360996246,
-0.14667314291000366,
0.07067960500717163,
0.0903003066778183,
-0.1128469929099083,
0.15435141324996948,
-0.26980602741241455,
0.2791990637779236,
0.09973997622728348,
-0.020342355594038963,
0.05670126527547836,
0.02431321330368519,
-0.0012381685664877295,
0.34197407960891724,
-0.10089224576950073,
-0.08707863837480545,
-0.06540809571743011,
0.28847166895866394,
0.04114453122019768,
0.030053045600652695,
-0.287735253572464,
-0.28092896938323975,
-0.11704999208450317,
0.18205812573432922,
-0.060954514890909195,
-0.08758296817541122,
0.03918146342039108,
-0.08178123086690903,
-0.09261937439441681,
-0.029483197256922722,
0.1627439260482788,
-0.1266735941171646,
-0.32272788882255554,
-0.019764607772231102,
0.009620116092264652,
0.07774811238050461,
0.08253826200962067,
0.09672769904136658,
-0.26308009028434753,
-0.14296695590019226,
-0.09007980674505234,
-0.062130220234394073,
0.12958554923534393,
0.15408192574977875,
0.04704563692212105,
-0.0037184678949415684,
0.026208991184830666,
0.0010655357036739588,
0.009396829642355442,
0.059798598289489746,
0.011315054260194302,
0.053956348448991776,
0.09594295918941498,
0.12725189328193665,
0.07741767168045044,
0.023684930056333542,
0.026398146525025368,
-0.2064666748046875,
-0.15295802056789398,
0.0007472411962226033,
0.1646764725446701,
0.1084071472287178,
-0.140804722905159,
-0.002099573379382491,
-0.024125784635543823,
0.062479373067617416,
0.01270390022546053,
0.1698193997144699,
0.0001782142644515261,
0.3854179382324219,
0.1412338763475418,
0.10752826184034348,
0.14002026617527008,
0.14117376506328583,
-0.19699037075042725,
0.01581183820962906,
-0.08909665048122406,
-0.038717832416296005,
0.03694019839167595,
0.011468482203781605,
0.023874184116721153,
0.18105214834213257,
0.017512479797005653,
0.2650549113750458,
0.10633540898561478,
0.49200746417045593,
0.24291040003299713,
-0.1156977117061615,
-0.1092638298869133,
0.0585641972720623,
0.08955372124910355,
0.10664242506027222,
-0.013925407081842422,
0.20384888350963593,
-0.03579864278435707,
0.01785062812268734,
-0.04909421503543854,
-0.04006965830922127,
-0.003238894511014223,
-0.10660958290100098,
-0.03200763091444969,
-0.19278369843959808,
-0.1496848315000534,
0.11368416249752045,
-0.26649022102355957,
0.14642903208732605,
0.089385487139225,
0.0252798181027174,
0.1929853856563568,
-0.046111345291137695,
0.12665268778800964,
0.27065351605415344,
0.05426474288105965,
0.08330787718296051,
-0.06977149844169617,
-0.1653657704591751,
-0.17053048312664032,
-0.17936024069786072,
-0.04996030032634735,
-0.04298839718103409,
-0.02313436008989811,
-0.09656420350074768,
-0.05174526944756508,
0.022734563797712326,
-0.04296485334634781,
0.11175237596035004,
-0.10545229911804199,
0.17337077856063843,
-0.1301499754190445,
0.18561521172523499,
0.16444498300552368,
0.03387831524014473,
0.14462390542030334,
0.11280597746372223,
0.08962661027908325,
0.025619611144065857,
-0.10088396072387695,
0.1027541235089302,
-0.2522135376930237,
0.1700991541147232,
-0.1547582894563675,
0.024258414283394814,
0.2559536397457123,
-0.18802721798419952,
-0.0786963552236557,
-0.012126282788813114,
0.13242076337337494,
0.0683472752571106,
0.1493578404188156,
0.03984249010682106,
-0.040873464196920395,
0.00381501205265522,
0.1349497139453888,
-0.0420161634683609,
0.09795212000608444,
-0.07975819706916809,
-0.04080049693584442,
-0.023671867325901985,
-0.027885345742106438,
-0.21837057173252106,
-0.026989923790097237,
0.10069610923528671,
0.05158596113324165,
-0.21037927269935608,
0.23209765553474426,
-0.014404320158064365,
-0.35378608107566833,
-0.23159636557102203,
-0.0840989276766777,
-0.21015502512454987,
-0.07427782565355301,
-0.1852351725101471,
0.1745109111070633,
-0.15664011240005493,
-0.007924369536340237,
0.09576868265867233,
0.045726265758275986,
-0.13560082018375397,
-0.08822736144065857,
0.014902280643582344,
0.231825053691864,
0.019578389823436737,
0.1040644496679306,
-0.2161497175693512,
0.21860219538211823,
0.005296478047966957,
-0.08384211361408234,
-0.022548414766788483,
-0.11456841975450516,
0.11571256071329117,
0.07174432277679443,
-0.0425325445830822,
-0.3027549386024475,
-0.0054186321794986725,
-0.20740757882595062,
0.08749301731586456,
0.09673977643251419,
-0.35399681329727173,
-0.035892777144908905,
0.026485847309231758,
-0.06251517683267593,
-0.06174526363611221,
-0.044393207877874374,
-0.0321287177503109,
0.0070973606780171394,
0.04513292759656906,
0.07813724130392075,
0.05411404371261597,
-0.0385391004383564,
-0.17856697738170624,
0.052475668489933014,
-0.11743980646133423,
-0.11202122271060944,
-0.27042725682258606,
0.1524781733751297,
0.11999734491109848,
0.015117445029318333,
-0.02064366079866886,
0.013488567434251308,
-0.00480252131819725,
0.10589758306741714,
0.08307485282421112,
-0.0668698325753212,
0.09000301361083984,
0.08012426644563675,
-0.0700925663113594,
-0.04483868554234505,
0.27356597781181335,
0.09824822098016739,
-0.113541379570961,
0.057559866458177567,
0.20057854056358337,
0.06297201663255692,
0.1744595468044281,
-0.02317984402179718,
-0.0844469740986824,
-0.07810597121715546,
0.22678840160369873,
0.14650526642799377,
0.039522141218185425,
0.040281616151332855,
0.05187775567173958,
0.08351026475429535,
-0.13602370023727417,
0.3536723554134369,
-0.16876447200775146,
-0.07951408624649048,
0.17590449750423431,
-0.051002759486436844,
-0.0241275355219841,
0.017460200935602188,
-0.106131911277771,
0.0674876868724823,
-0.17544282972812653,
-0.0479978509247303,
-0.019630007445812225,
0.0038353600539267063,
-0.19433175027370453,
0.0785016193985939,
0.14957498013973236,
-0.0019230832112953067,
-0.028243795037269592,
0.018905166536569595,
0.09837236255407333,
0.11273394525051117,
-0.1677526980638504,
0.07170099020004272,
-0.034012265503406525,
-0.05008136108517647,
-0.0456341877579689,
0.03929492086172104,
0.05703256279230118,
-0.15166203677654266,
0.07678604871034622,
-0.10604477673768997,
-0.22306381165981293,
-0.15502554178237915,
-0.09156254678964615,
-0.0474935844540596,
0.03710969164967537,
-0.13280180096626282,
-0.009159461595118046,
-0.212135910987854,
-0.05653168633580208,
-0.1912527233362198,
0.04705265164375305,
-0.10966712236404419,
-0.04676986485719681,
0.07662199437618256,
0.06610040366649628,
0.019506892189383507,
0.10929209738969803,
-0.29906585812568665,
0.040464531630277634,
-0.17434340715408325,
-0.057418208569288254,
-0.07900440692901611,
0.13680624961853027,
0.0436943881213665,
-0.04281211271882057,
0.18141548335552216,
-0.11214352399110794,
-0.19691826403141022,
0.14377079904079437,
0.0373975969851017,
0.10958409309387207,
-0.09251458197832108,
-0.020592838525772095,
0.08610033243894577,
0.011351288296282291,
0.0512770339846611,
0.20796476304531097,
-0.05230896547436714,
0.03436187654733658,
0.14187857508659363,
-0.06466414034366608,
-0.11635785549879074,
-0.2085314691066742,
0.19837866723537445,
-0.1324116736650467,
0.08234046399593353,
-0.09305434674024582,
-0.17295710742473602,
-0.1639174073934555,
0.2246309220790863,
-0.10618197172880173,
0.018142694607377052,
-0.024732669815421104,
0.08251909166574478,
-0.295737087726593,
0.11781863123178482,
-0.010370294563472271,
-0.2098451852798462,
0.0701024979352951,
0.17539769411087036,
-0.0534665547311306,
0.2432321310043335,
-0.022535080090165138,
0.003020387841388583,
0.1958395540714264,
-0.14857400953769684,
-0.22243434190750122,
0.063590407371521,
-0.13969838619232178,
0.028086509555578232,
0.1584816426038742,
0.4425438344478607,
0.03446682542562485,
-0.12204603850841522,
-0.04628286883234978,
-0.10241071879863739,
0.07224570959806442,
0.26999637484550476,
-0.24218261241912842,
0.08034765720367432,
-0.025251423940062523,
-0.12237352132797241,
-0.15671607851982117,
-0.05883195623755455,
-0.06178276613354683,
0.03807586804032326,
0.08256080746650696,
-0.011790607124567032,
0.05749373510479927,
-0.08046942204236984,
0.2555226981639862,
0.0986407920718193,
-0.19790787994861603,
0.027114491909742355,
-0.058307379484176636,
0.0493437759578228,
0.07608724385499954,
0.20764072239398956,
0.3210696280002594,
-0.25315284729003906,
-0.14891016483306885,
0.06269237399101257,
0.09033431112766266,
-0.1657901257276535,
0.16017423570156097,
0.3353457450866699,
0.15249530971050262,
-0.08067945390939713,
0.2865857481956482,
0.18503952026367188,
-0.07753420621156693,
0.2761782705783844,
-0.004515524487942457,
0.07026583701372147,
0.19990523159503937,
0.1393405795097351,
0.07689682394266129,
0.08084981143474579,
0.01587444357573986,
-0.04544265195727348,
0.0318918339908123,
-0.054861437529325485,
0.26635438203811646,
0.16024330258369446,
-0.27305901050567627,
0.19548344612121582,
0.059548575431108475,
0.025598440319299698,
-0.024122921749949455,
0.14714039862155914,
0.21629108488559723,
0.047535937279462814,
0.020928869023919106,
-0.005964227486401796,
-0.15956512093544006,
0.06107902154326439,
-0.06608355790376663,
-0.02529342658817768,
0.11015231162309647,
-0.015389821492135525,
0.013570069335401058,
-0.07072022557258606,
-0.060351014137268066,
0.3204060196876526,
-0.30739447474479675,
0.018807485699653625,
-0.17301076650619507,
0.28116437792778015,
0.09897851943969727,
0.09175676852464676,
-0.1487678587436676,
-0.09387890994548798,
0.035910625010728836,
0.13573305308818817,
0.07790885865688324,
-0.10610561817884445,
0.3743062913417816,
0.009384539909660816,
0.005455127451568842,
-0.11214679479598999,
0.11222188919782639,
0.31461718678474426,
-0.09186631441116333,
0.054865941405296326,
0.12285003811120987,
0.04102242738008499,
-0.2079313099384308,
-0.006797025445848703,
-0.07533200085163116,
0.15301461517810822,
0.1670437455177307,
0.06393302977085114,
0.1877042055130005,
0.07239747792482376,
0.187982976436615,
-0.14689598977565765,
0.07871692627668381,
0.17487215995788574,
-0.11625008285045624,
-0.25918927788734436,
0.05929724872112274,
0.05133043974637985,
0.0036766387056559324,
-0.05105791240930557,
0.02608511783182621,
0.23061877489089966,
0.16340190172195435,
-0.2035222202539444,
-0.15722514688968658,
-0.13854172825813293,
0.010343758389353752,
0.1065944954752922,
-0.06802098453044891,
-0.06219623237848282,
-0.08400489389896393,
0.24328674376010895,
0.0006327444571070373,
-0.15934978425502777,
-0.08654020726680756,
0.08664244413375854,
-0.026556892320513725,
0.05745841935276985,
0.07712874561548233,
0.23707892000675201,
0.16728489100933075,
-0.0058217826299369335,
-0.006808910984545946,
-0.07446301728487015,
-0.006845129653811455,
-0.10129227489233017,
0.23897776007652283,
0.2007015496492386,
-0.24239857494831085,
0.09010905027389526,
0.10328423231840134,
-0.09939149022102356,
-0.008746679872274399,
0.0025159327778965235,
0.05485457554459572,
0.0453440323472023,
-0.03142966702580452,
-0.23649069666862488,
-0.14096233248710632,
-0.17230965197086334,
0.04867397993803024,
0.14317917823791504,
0.06298854947090149,
0.1956844925880432,
-0.20931871235370636,
-0.006730919703841209,
-0.19344225525856018,
-0.1506495177745819,
0.10617265105247498,
0.29404065012931824,
0.3417811691761017,
-0.1141701191663742,
0.1066654846072197,
-0.14827421307563782,
0.06258609890937805,
-0.21824495494365692,
0.12675848603248596,
-0.2182108610868454,
-0.1948930025100708,
0.064651258289814,
-0.09168130159378052,
-0.19280049204826355,
-0.01968943141400814,
0.16368559002876282,
-0.1215716227889061,
-0.40464353561401367,
-0.25990334153175354,
-0.08719951659440994,
0.05312022194266319,
-0.05673312395811081,
0.1683426946401596,
0.2760258615016937,
0.17079229652881622,
0.14832283556461334,
-0.028813781216740608,
-0.05933491513133049,
-0.0932658389210701,
-0.0961708277463913,
0.1923997402191162,
-0.11354720592498779,
-0.1297784149646759,
-0.035303693264722824,
0.0951930582523346,
-0.0052705504931509495,
-0.028898097574710846,
0.10536401718854904,
-0.030580556020140648,
-0.19153758883476257,
0.0007625877624377608,
0.06350904703140259,
0.3517857789993286,
-0.2550608515739441,
0.2282271683216095,
-0.12181686609983444,
-0.20738376677036285,
-0.08397041261196136,
0.11754447966814041,
-0.15929843485355377,
0.024825265631079674,
-0.21164466440677643,
0.09760662913322449,
-0.08272988349199295,
0.010194294154644012,
-0.11374667286872864,
0.20063050091266632,
-0.008953767828643322,
0.09833015501499176,
0.06515976786613464,
-0.08226652443408966,
0.014947720803320408,
-0.16502541303634644,
0.15609173476696014,
0.24435195326805115,
-0.15512464940547943,
0.13982869684696198,
-0.17320211231708527,
0.006661326624453068,
0.16314321756362915,
0.04137907922267914,
0.0832422599196434,
-0.06502395868301392,
-0.3121833801269531,
0.03306262195110321,
0.003782859304919839,
0.15517550706863403,
0.10279054939746857,
0.06450346112251282,
0.14135225117206573,
-0.10902570933103561,
0.0941702127456665,
0.04158693552017212,
-0.028274381533265114,
0.06096740812063217,
-0.2052251547574997,
0.01432870514690876,
0.18200621008872986,
-0.0575624443590641,
0.036042582243680954,
-0.062135934829711914,
-0.238128200173378,
0.11668024212121964,
-0.14579422771930695,
-0.2622208893299103,
0.10160044580698013,
-0.10807933658361435,
-0.15799398720264435,
-0.12212883681058884,
-0.0008171306108124554,
0.018213171511888504,
0.021666111424565315,
0.13313543796539307,
0.14009669423103333,
-0.252114474773407,
0.013381868600845337,
-0.1050032451748848,
0.03991296514868736,
0.0421740896999836,
0.03442281484603882,
0.016593463718891144,
-0.08541169762611389,
-0.05834633484482765,
-0.12481949478387833,
-0.03303876519203186,
0.425815224647522,
-0.09080398082733154,
-0.35867640376091003,
-0.07051067799329758,
-0.16353368759155273,
0.019366702064871788,
-0.16498850286006927,
-0.010124379768967628,
0.05250119790434837,
0.10596391558647156,
-0.16290076076984406,
-0.08120392262935638,
-0.2113501876592636,
0.015293095260858536,
0.16244086623191833,
0.016374774277210236,
-0.16972209513187408,
0.14627419412136078,
0.0863436758518219,
-0.051169656217098236,
0.263408899307251,
-0.05738295242190361,
0.08040639013051987,
-0.07502011209726334,
0.11345884203910828,
0.08350607007741928,
0.04004448279738426,
0.06274542957544327,
-0.2775023877620697,
0.09160958230495453,
-0.15870460867881775,
-0.0343766026198864,
-0.12532562017440796,
-0.20587009191513062,
0.24928057193756104,
-0.02880789339542389,
0.1077023446559906,
-0.13903357088565826,
0.11424033343791962,
-0.05806327983736992,
0.138811856508255,
-0.09667608886957169,
0.0151952113956213,
-0.14790277183055878,
0.004548667464405298,
0.27408626675605774,
0.10934223979711533,
-0.24922527372837067,
0.06147448718547821,
0.21704566478729248,
-0.04533122107386589,
-0.21941250562667847,
-0.3047063648700714,
-0.19728264212608337,
0.2127138376235962,
0.10577742755413055,
0.10610702633857727,
-0.022964103147387505,
0.06983280181884766,
-0.053790416568517685,
-0.2573179304599762,
-0.09790416061878204,
-0.025845801457762718,
-0.07346320152282715,
0.07226375490427017,
0.15115700662136078,
-0.21728570759296417,
0.0014422130770981312,
-0.019223321229219437,
-0.06930477917194366,
-0.2014528065919876,
0.14305990934371948,
-0.1388169229030609,
-0.05681402608752251,
-0.07960501313209534,
-0.09924234449863434,
-0.1015939936041832,
0.09943923354148865,
0.013408164493739605,
-0.06478779762983322,
0.2124047875404358,
-0.2658955752849579,
-0.26070964336395264,
0.22397688031196594,
0.05436931550502777,
0.07677485793828964,
0.007946481928229332,
0.06278815865516663,
0.3024422526359558
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. overgrowth in some individuals can result in difficult-to-control hemorrhaging and/or chronically weeping lymphatics.Deep vein thrombosis (DVT) and pulmonary embolism (PE). The authors recommend emergent evaluation of individuals who develop symptoms of DVT (e.g., palpable subcutaneous rope-like mass, swelling, erythema, pain, and distal venous congestion) or PE (e.g., shortness of breath, chest pain, and cough which may include hemoptysis). Because individuals with PE can be asymptomatic, it is recommended that an individual with a DVT be evaluated for PE regardless of symptoms.Evaluation for DVTs. In the absence of cardiopulmonary compromise, consider the D-dimer assay and/or ultrasonographic evaluation.Evaluation of PE. High-resolution chest CT (so called spiral CT) with contrast is recommended. Ventilation-perfusion nuclear medicine scanning may be appropriate in some individuals.Treatment of DVT and PE should follow recommended anticoagulation guidelines for these disorders. The | [
-0.15644164383411407,
-0.043187011033296585,
-0.11813250184059143,
-0.0964667946100235,
0.14097224175930023,
0.01030662376433611,
-0.16938379406929016,
0.1869618445634842,
-0.24918457865715027,
-0.16962528228759766,
0.41558802127838135,
-0.16771085560321808,
0.3722034692764282,
-0.15666331350803375,
0.07147185504436493,
0.4539285898208618,
0.10707688331604004,
-0.062083933502435684,
0.3155301809310913,
-0.1630352884531021,
0.0025219584349542856,
-0.05687013268470764,
0.08596707880496979,
-0.024245301261544228,
0.04912998154759407,
-0.08020912855863571,
0.12727832794189453,
0.08428876101970673,
-0.13973669707775116,
0.1085614562034607,
-0.2633688449859619,
0.08340781182050705,
0.11458685249090195,
-0.21655505895614624,
-0.2051292061805725,
-0.2819949984550476,
-0.23075653612613678,
0.06571094691753387,
0.156202495098114,
0.22775740921497345,
-0.10350526124238968,
0.0645001232624054,
0.10515013337135315,
-0.2220160812139511,
0.27088597416877747,
-0.230872243642807,
0.06855586916208267,
-0.012113185599446297,
-0.12294294685125351,
0.21939215064048767,
-0.030585866421461105,
0.3209419846534729,
0.2134842425584793,
-0.05531204864382744,
0.15490685403347015,
-0.4407367706298828,
-0.03757963329553604,
-0.032364677637815475,
-0.03835718706250191,
0.027905547991394997,
0.013462688773870468,
0.06849201768636703,
0.10408835858106613,
-0.13099822402000427,
0.28749898076057434,
-0.0024787650909274817,
0.02375401183962822,
0.08807369321584702,
0.009106957353651524,
0.035163749009370804,
0.44636037945747375,
-0.08786174654960632,
-0.28867968916893005,
0.12095756828784943,
0.2501753568649292,
0.09618455171585083,
0.014023678377270699,
-0.10217556357383728,
-0.12580657005310059,
-0.2059910148382187,
0.10854647308588028,
-0.14620402455329895,
-0.045263756066560745,
0.0030689816921949387,
-0.08967144787311554,
-0.306868314743042,
-0.034272171556949615,
0.26552969217300415,
-0.1408466100692749,
-0.15192252397537231,
0.042089834809303284,
-0.16530826687812805,
0.056074097752571106,
0.20335640013217926,
0.3124231994152069,
-0.21680249273777008,
0.07935460656881332,
0.05579245090484619,
0.085979163646698,
0.030135303735733032,
0.043302953243255615,
0.14911150932312012,
-0.25119420886039734,
0.027805348858237267,
-0.06451015174388885,
-0.11215566843748093,
0.008530733175575733,
-0.1259477585554123,
0.14576472342014313,
0.0401579923927784,
0.2863822281360626,
0.14151619374752045,
0.20068207383155823,
0.12816889584064484,
-0.1259610950946808,
-0.1822921186685562,
0.10076539218425751,
0.04369689151644707,
-0.03136052191257477,
-0.14584887027740479,
-0.19402800500392914,
-0.005595676135271788,
0.24203547835350037,
-0.19739684462547302,
0.3869497776031494,
-0.1798122525215149,
0.4487479627132416,
-0.1523112654685974,
-0.08131646364927292,
0.027577875182032585,
0.015727385878562927,
-0.08627644181251526,
0.051466964185237885,
-0.18538309633731842,
0.13182392716407776,
0.20118196308612823,
-0.056431178003549576,
0.021559543907642365,
0.18424512445926666,
0.1690305769443512,
0.07837461680173874,
0.068178690969944,
0.27972614765167236,
0.2792038023471832,
-0.17506805062294006,
0.05523761734366417,
-0.19169525802135468,
-0.10140078514814377,
0.10248412191867828,
-0.04017762467265129,
0.18614834547042847,
-0.059659138321876526,
0.1434108018875122,
0.11358729004859924,
0.009099536575376987,
0.07630491256713867,
-0.11488986015319824,
0.15900775790214539,
-0.13842998445034027,
-0.18440651893615723,
-0.09754732251167297,
-0.3846988081932068,
0.049661990255117416,
0.07521355897188187,
0.14915312826633453,
0.2248806208372116,
0.19289711117744446,
0.049998171627521515,
0.2453387826681137,
-0.13576814532279968,
0.09750475734472275,
-0.030554208904504776,
0.06714744865894318,
0.006944252178072929,
-0.03169489651918411,
-0.10718180984258652,
0.0587034747004509,
0.09707168489694595,
-0.11479444056749344,
0.10732113569974899,
0.08864752948284149,
-0.04028681665658951,
-0.11857780814170837,
-0.0881330743432045,
0.23492272198200226,
-0.16051648557186127,
0.07348649203777313,
0.12889058887958527,
-0.040140923112630844,
0.17871978878974915,
-0.02006693184375763,
-0.002700303215533495,
-0.0431068055331707,
-0.24547865986824036,
-0.08228469640016556,
-0.18866640329360962,
0.056324101984500885,
-0.21442382037639618,
0.1936263144016266,
0.2805127799510956,
-0.06376122683286667,
-0.03555180877447128,
-0.15956223011016846,
0.12908604741096497,
0.21121826767921448,
0.21990863978862762,
0.08640022575855255,
-0.293944388628006,
-0.002574523678049445,
0.04789261519908905,
-0.08741059899330139,
0.19988438487052917,
-0.06815992295742035,
0.1236695796251297,
0.02504068985581398,
0.11735808849334717,
-0.1925475299358368,
0.04731622338294983,
0.03661671653389931,
0.1805287003517151,
-0.2530609965324402,
0.24286510050296783,
-0.22051793336868286,
-0.17732401192188263,
-0.2646397650241852,
-0.20772823691368103,
-0.08579163253307343,
-0.1982017159461975,
0.06183503195643425,
-0.020283007994294167,
-0.16921614110469818,
-0.13071539998054504,
0.08895270526409149,
0.23506486415863037,
0.1417582929134369,
-0.2577548325061798,
0.11857704073190689,
0.329857736825943,
0.2623771131038666,
-0.2201814353466034,
-0.0708695501089096,
0.1246064305305481,
-0.06862252205610275,
-0.0018584702629595995,
0.07468105107545853,
0.07002220302820206,
-0.07645659893751144,
0.427386075258255,
0.008360478095710278,
-0.14789384603500366,
-0.0385718010365963,
-0.29515355825424194,
-0.008804836310446262,
0.1648699939250946,
-0.23630358278751373,
-0.1596681773662567,
0.161612406373024,
-0.12635305523872375,
-0.0303812213242054,
-0.07950592041015625,
0.12473246455192566,
-0.04311249777674675,
0.39803841710090637,
0.1467018723487854,
-0.007483635563403368,
-0.12058382481336594,
-0.0265011228621006,
0.05060525983572006,
-0.15852263569831848,
-0.12593427300453186,
-0.29622557759284973,
0.16549324989318848,
0.19241344928741455,
0.11040685325860977,
-0.009130819700658321,
0.24985694885253906,
0.19566453993320465,
0.2452179491519928,
0.08863776177167892,
-0.01647358573973179,
-0.03377741575241089,
0.11233168095350266,
-0.18657554686069489,
-0.049363452941179276,
0.23389795422554016,
0.14984817802906036,
-0.07836171239614487,
-0.03687644377350807,
0.2721893787384033,
0.11298612505197525,
0.07854247838258743,
0.014282003045082092,
-0.22519958019256592,
0.12645336985588074,
0.5051704049110413,
0.1418951004743576,
0.20123517513275146,
-0.1845511496067047,
0.07359762489795685,
-0.2096121907234192,
0.19301019608974457,
0.4550683796405792,
-0.39196136593818665,
-0.004601634573191404,
-0.1683860868215561,
-0.10945385694503784,
0.0058095077984035015,
-0.05354437977075577,
0.18552881479263306,
0.1524065136909485,
-0.31273794174194336,
0.0963086485862732,
-0.015721239149570465,
-0.04657832160592079,
0.002220324706286192,
0.1773427575826645,
0.09332572668790817,
-0.20194736123085022,
0.14697235822677612,
-0.1712065488100052,
0.09364084154367447,
-0.056394174695014954,
0.04196003079414368,
0.004375150427222252,
-0.11682234704494476,
0.13356168568134308,
-0.2527606785297394,
0.050122104585170746,
0.11639892309904099,
-0.3586747348308563,
-0.16254989802837372,
-0.07572875916957855,
-0.5520896911621094,
-0.359723299741745,
-0.07588469237089157,
0.18499115109443665,
0.03376651182770729,
0.048810943961143494,
-0.05987866595387459,
-0.1403483897447586,
-0.05467967689037323,
-0.0880463495850563,
0.01882064715027809,
-0.08042735606431961,
0.09131080657243729,
0.11173565685749054,
0.12395928055047989,
-0.11443772166967392,
0.11670397967100143,
-0.12371327728033066,
-0.04602793604135513,
-0.21023094654083252,
-0.11758441478013992,
0.04369058832526207,
0.49047982692718506,
0.16965995728969574,
-0.0428665429353714,
0.34018632769584656,
-0.1586744487285614,
-0.20981623232364655,
0.11027677357196808,
0.08790259063243866,
-0.06125563383102417,
-0.053757671266794205,
0.19800591468811035,
-0.00403384817764163,
0.03536350280046463,
0.2492501139640808,
0.3424452245235443,
-0.07156723737716675,
0.12599068880081177,
-0.01780613884329796,
-0.1193360984325409,
0.028813855722546577,
-0.22307313978672028,
0.20086660981178284,
-0.2044428586959839,
0.18804873526096344,
-0.1083507388830185,
-0.20356400310993195,
-0.07133501023054123,
0.2777356505393982,
-0.21518757939338684,
-0.21717029809951782,
-0.023448964580893517,
0.2834303677082062,
-0.2945443093776703,
0.304036408662796,
-0.1171208992600441,
-0.031254563480615616,
0.20749007165431976,
0.1940755844116211,
0.01009249035269022,
-0.046826835721731186,
-0.045359913259744644,
-0.04683756083250046,
0.07503540068864822,
-0.3269650936126709,
0.07896966487169266,
0.03754918649792671,
-0.16537831723690033,
0.06202998012304306,
0.3442399501800537,
0.4438454508781433,
-0.14925505220890045,
0.032659437507390976,
0.06357351690530777,
-0.11164619773626328,
0.061030853539705276,
0.16640619933605194,
-0.09879640489816666,
-0.07260701060295105,
0.039429064840078354,
-0.20266185700893402,
-0.06492693722248077,
-0.2137644737958908,
-0.15403695404529572,
0.03221740201115608,
-0.05415918305516243,
0.04921158030629158,
0.09077577292919159,
-0.022451579570770264,
0.2419392615556717,
-0.008445700630545616,
-0.40491148829460144,
0.15792818367481232,
-0.18854612112045288,
0.03138364851474762,
0.11160951107740402,
0.08004553616046906,
0.30258217453956604,
-0.054122067987918854,
-0.11174174398183823,
0.09064816683530807,
0.02349863015115261,
-0.1308627724647522,
-0.07491572201251984,
0.21305899322032928,
0.13839071989059448,
-0.08254692703485489,
0.2726832926273346,
0.22381138801574707,
-0.031506869941949844,
0.31743964552879333,
0.20901712775230408,
-0.14267034828662872,
0.16776704788208008,
0.1034606322646141,
0.03980882838368416,
-0.020198697224259377,
0.15527546405792236,
-0.045802533626556396,
0.03680446371436119,
0.005388414487242699,
0.46182164549827576,
-0.05124495550990105,
-0.034145988523960114,
0.12933233380317688,
-0.009374675340950489,
-0.20414748787879944,
0.028560737147927284,
-0.034909918904304504,
0.18004827201366425,
-0.0008681767503730953,
-0.09345751255750656,
0.15566706657409668,
0.03252842277288437,
0.029645834118127823,
-0.036335501819849014,
-0.08333911001682281,
0.12680496275424957,
0.1729317307472229,
0.21426497399806976,
-0.10472779721021652,
-0.17373217642307281,
0.10388302057981491,
-0.327017605304718,
0.11300210654735565,
0.20034626126289368,
0.2511886656284332,
0.20081530511379242,
0.16424959897994995,
-0.15075545012950897,
0.03352273628115654,
-0.010965119116008282,
0.189543679356575,
0.1882203370332718,
-0.04397492855787277,
0.13553187251091003,
-0.18802621960639954,
0.045536138117313385,
-0.2870498299598694,
0.16349925100803375,
0.25897470116615295,
-0.04070515185594559,
-0.010608145967125893,
0.0721488818526268,
0.08500732481479645,
-0.23304930329322815,
-0.14449825882911682,
-0.25419434905052185,
0.16500315070152283,
0.20347356796264648,
0.0010509890271350741,
0.06495939195156097,
0.13629254698753357,
0.2663832902908325,
-0.2649698257446289,
-0.08331429958343506,
0.21694748103618622,
-0.2780228555202484,
-0.40363529324531555,
-0.12118176370859146,
-0.03465265408158302,
0.03891352564096451,
-0.08609804511070251,
0.28864189982414246,
0.22747664153575897,
0.13528025150299072,
-0.10662072151899338,
-0.1946522295475006,
-0.18137624859809875,
-0.11564262211322784,
0.04907217621803284,
-0.17079415917396545,
-0.2326352298259735,
-0.07124415785074234,
0.24526642262935638,
0.00913176592439413,
-0.06243567913770676,
-0.07561296224594116,
0.09274939447641373,
-0.1464548408985138,
0.11097406595945358,
0.18631255626678467,
0.1333463340997696,
0.14496588706970215,
-0.22674772143363953,
-0.1415126472711563,
0.033320508897304535,
0.11533606797456741,
-0.26878100633621216,
0.19024212658405304,
0.4035954475402832,
-0.11251601576805115,
0.041095420718193054,
0.014168831519782543,
-0.14530730247497559,
0.2191283255815506,
-0.024188145995140076,
0.06871569901704788,
0.09902098774909973,
0.21052493155002594,
-0.10803638398647308,
-0.17996029555797577,
-0.09082991629838943,
0.12782301008701324,
0.025008905678987503,
0.06893622875213623,
0.07067841291427612,
-0.3572126626968384,
-0.014717275276780128,
-0.1643572300672531,
-0.15293800830841064,
-0.06865265220403671,
0.35876670479774475,
0.3721059262752533,
-0.22794249653816223,
0.07339725643396378,
-0.23051145672798157,
0.12714047729969025,
0.06872712075710297,
0.09179693460464478,
-0.2820001244544983,
-0.28308045864105225,
-0.2551182210445404,
-0.1656688153743744,
-0.1663183718919754,
-0.003693465841934085,
0.014956049621105194,
0.06568605452775955,
-0.359721302986145,
-0.11781670153141022,
-0.24613498151302338,
0.17175571620464325,
-0.18976791203022003,
0.16127702593803406,
0.3828570544719696,
0.13044968247413635,
0.1258958876132965,
-0.014914905652403831,
0.03083612769842148,
-0.00309568177908659,
0.15434803068637848,
-0.11875166743993759,
-0.14516223967075348,
0.16840872168540955,
-0.06882457435131073,
-0.028788000345230103,
-0.09396874159574509,
-0.02739633247256279,
0.023083100095391273,
0.09614361077547073,
-0.13355758786201477,
0.35155951976776123,
0.19846798479557037,
0.19432339072227478,
-0.1765470802783966,
0.17112886905670166,
-0.05385233461856842,
-0.19134962558746338,
-0.026996852830052376,
0.20141762495040894,
-0.06839324533939362,
0.08959654718637466,
-0.30051514506340027,
0.10260843485593796,
0.131520614027977,
0.2658751904964447,
-0.17807863652706146,
0.40619608759880066,
0.02244524471461773,
0.06970321387052536,
0.1469751000404358,
-0.21220830082893372,
-0.08096659183502197,
-0.04804462939500809,
0.289066344499588,
0.12811172008514404,
-0.2364167720079422,
0.21097104251384735,
-0.1935013234615326,
-0.03336887061595917,
0.2635066509246826,
0.17220227420330048,
0.2723986804485321,
-0.13726277649402618,
-0.2311505824327469,
-0.22997978329658508,
0.1747819185256958,
0.0126534104347229,
-0.0463186539709568,
0.05912094563245773,
0.08585033565759659,
-0.2382679432630539,
-0.0167216956615448,
0.1320561170578003,
-0.3164597153663635,
-0.04490748792886734,
-0.008848077617585659,
-0.002847370458766818,
0.1527877300977707,
-0.102005735039711,
0.10053333640098572,
-0.16154278814792633,
-0.20476087927818298,
0.2981956899166107,
0.010914678685367107,
-0.14017654955387115,
0.08880586177110672,
0.024214506149291992,
-0.1717997044324875,
0.06072338670492172,
0.1311224400997162,
0.022715745493769646,
0.029776128008961678,
0.023560870438814163,
-0.00953570008277893,
-0.12014841288328171,
0.05500934273004532,
-0.027705498039722443,
0.29754728078842163,
0.097049780189991,
0.14537373185157776,
-0.12504181265830994,
-0.10454922169446945,
0.20724231004714966,
-0.049657613039016724,
-0.03951362892985344,
0.1854080706834793,
0.16116496920585632,
-0.40093445777893066,
0.003988273441791534,
0.1463204175233841,
0.22737982869148254,
-0.07443397492170334,
0.11922252178192139,
0.05903337150812149,
0.056809064000844955,
-0.13709969818592072,
0.00014944637950975448,
-0.1191360279917717,
-0.01388462819159031,
0.06562091410160065,
-0.012263575568795204,
-0.24079717695713043,
0.30723434686660767,
-0.11982394009828568,
0.16543099284172058,
0.11225913465023041,
-0.013421437703073025,
0.19249440729618073,
-0.0842864140868187,
0.08083555847406387,
0.05738194286823273,
-0.2871589958667755,
0.001197526347823441,
-0.206141859292984,
0.25760209560394287,
-0.09143823385238647,
0.05901351571083069,
-0.023533176630735397,
-0.23049397766590118,
0.2259666472673416,
-0.2398516684770584,
0.08179248124361038,
-0.2562454044818878,
-0.06164918094873428,
-0.06418602913618088,
-0.012858688831329346,
-0.1196858212351799,
0.27816399931907654,
-0.2606201767921448,
0.04978300631046295,
0.031444650143384933,
0.032846998423337936,
-0.5893884897232056,
0.18701888620853424,
0.18819288909435272,
-0.18738797307014465,
-0.11335483938455582,
-0.3752900958061218,
-0.20714807510375977,
0.008260305039584637,
-0.03040732443332672,
0.07459022104740143,
0.045393336564302444,
-0.16482920944690704,
-0.0985015258193016,
-0.19788858294487,
-0.12992337346076965,
-0.016628244891762733,
-0.06500336527824402,
0.004836471285670996,
0.26519113779067993,
0.09554245322942734,
-0.1350240707397461,
0.10871122777462006,
-0.13664329051971436,
-0.09258241951465607,
-0.009166521020233631,
-0.21249279379844666,
0.13385039567947388,
-0.2239927500486374,
-0.16858160495758057,
-0.2596314251422882,
0.17572976648807526,
-0.21888341009616852,
0.026758994907140732,
0.13633859157562256,
-0.26973381638526917,
-0.1843981295824051,
0.0700606107711792,
0.06103657931089401,
0.4140512943267822,
0.17975422739982605,
-0.0017286838265135884,
0.13163505494594574
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. optysis). Because individuals with PE can be asymptomatic, it is recommended that an individual with a DVT be evaluated for PE regardless of symptoms.Evaluation for DVTs. In the absence of cardiopulmonary compromise, consider the D-dimer assay and/or ultrasonographic evaluation.Evaluation of PE. High-resolution chest CT (so called spiral CT) with contrast is recommended. Ventilation-perfusion nuclear medicine scanning may be appropriate in some individuals.Treatment of DVT and PE should follow recommended anticoagulation guidelines for these disorders. The authors recommend hematologic evaluation and consultation for consideration of anticoagulant prophylaxis for individuals undergoing surgery or other procedures that may predispose to DVT/PE.Tumors. It is impractical to screen for tumors with imaging in individuals with PS because the tumors are so heterogeneous. Instead, a primary care clinician should evaluate the individuals regularly (every 6-12 months) and elicit signs and symptoms of malignancy (e.g., pain, unexpected growths, signs of obstruction or compression). If | [
-0.04635614529252052,
0.10551109164953232,
-0.05539802089333534,
-0.29090946912765503,
0.08478428423404694,
-0.18456707894802094,
-0.045672256499528885,
0.29932287335395813,
-0.2577827274799347,
-0.2895037829875946,
0.49131983518600464,
-0.052688390016555786,
0.1629035770893097,
-0.12428316473960876,
0.2782667279243469,
0.3343375623226166,
0.0728350430727005,
-0.0406649112701416,
0.5522732138633728,
-0.04680036008358002,
0.1836695522069931,
-0.13009588420391083,
0.09558526426553726,
-0.04615076631307602,
-0.025443371385335922,
-0.06809351593255997,
0.04532318189740181,
0.021310770884156227,
-0.20895692706108093,
0.029921764507889748,
-0.31832149624824524,
0.0397108793258667,
0.18505622446537018,
-0.33970874547958374,
-0.3567362129688263,
-0.3382857143878937,
-0.2212848961353302,
0.13430635631084442,
0.014350475743412971,
0.19668059051036835,
-0.04449247196316719,
-0.1458844542503357,
0.1424403339624405,
-0.1126522421836853,
0.2720445990562439,
-0.27324631810188293,
0.026577571406960487,
-0.0880792886018753,
-0.05710282549262047,
0.10546651482582092,
-0.15970268845558167,
0.4517255127429962,
0.10576146095991135,
0.11362475901842117,
0.23879598081111908,
-0.364799439907074,
-0.07665489614009857,
0.10813972353935242,
-0.0475398525595665,
-0.09125427156686783,
0.05943042039871216,
0.1930980533361435,
0.12790869176387787,
0.08314788341522217,
0.232810840010643,
-0.04657527804374695,
-0.031047191470861435,
0.09210563451051712,
0.10182978957891464,
-0.1179514154791832,
0.1679578423500061,
0.13141556084156036,
-0.16956385970115662,
0.028731677681207657,
0.311426043510437,
0.1622687429189682,
0.05486731603741646,
-0.08966413140296936,
0.07200504094362259,
-0.33909669518470764,
0.11307106912136078,
-0.1519802212715149,
0.05340762436389923,
0.09992848336696625,
-0.12288679927587509,
-0.28251945972442627,
0.19136835634708405,
0.32944151759147644,
-0.14459095895290375,
-0.05028872564435005,
-0.2341620773077011,
-0.17981836199760437,
0.07940959185361862,
0.3803218901157379,
0.3143571615219116,
-0.20672902464866638,
0.07899843901395798,
0.09006426483392715,
0.20578081905841827,
0.11127068102359772,
0.1519147753715515,
0.11687216907739639,
-0.16408082842826843,
-0.02122608572244644,
0.02545051835477352,
-0.0010163235710933805,
0.007641916163265705,
-0.25893136858940125,
0.18025028705596924,
0.061890821903944016,
0.1008000373840332,
0.1766897290945053,
0.22858308255672455,
0.08800579607486725,
-0.06969983130693436,
-0.28080666065216064,
0.1336892992258072,
0.07976328581571579,
-0.013591034337878227,
0.030404383316636086,
-0.2128741443157196,
-0.12511129677295685,
0.12024074047803879,
-0.22585536539554596,
0.20624767243862152,
-0.22672566771507263,
0.29118111729621887,
-0.11787833273410797,
-0.14995411038398743,
-0.0068722013384103775,
0.0699891671538353,
0.04124903306365013,
-0.018062017858028412,
-0.1740829348564148,
0.14144723117351532,
0.18376030027866364,
-0.09502635151147842,
0.01744050160050392,
0.19625574350357056,
0.1727340668439865,
0.25448909401893616,
0.09215822070837021,
0.18557541072368622,
0.0844302549958229,
-0.2678984999656677,
0.09335819631814957,
-0.259897381067276,
-0.040476128458976746,
0.16614100337028503,
-0.037699609994888306,
0.3102249801158905,
-0.016678761690855026,
-0.12257681041955948,
0.13248459994792938,
-0.09954176098108292,
0.03610493242740631,
-0.009092412889003754,
0.23909777402877808,
-0.1776299625635147,
-0.2782589793205261,
-0.26583319902420044,
-0.21310308575630188,
-0.007873574271798134,
0.05650027096271515,
0.14613290131092072,
0.33383142948150635,
0.22670792043209076,
0.07671744376420975,
-0.06454811245203018,
-0.24688933789730072,
0.09028319269418716,
0.13010285794734955,
-0.06181429699063301,
0.015534771606326103,
0.029815632849931717,
0.07687819749116898,
0.0646931529045105,
0.16147549450397491,
0.01706838794052601,
0.1440882533788681,
0.01451466977596283,
-0.12304385751485825,
-0.021052200347185135,
-0.07841174304485321,
0.11680752038955688,
-0.05649029463529587,
-0.08360335975885391,
0.21610328555107117,
-0.006799747701734304,
0.12796147167682648,
0.23184765875339508,
0.03766707330942154,
0.031263820827007294,
-0.20055058598518372,
-0.1303938776254654,
-0.1906602531671524,
-0.0348861999809742,
-0.14624609053134918,
0.2453353852033615,
0.1945807933807373,
-0.08461416512727737,
-0.09691809117794037,
-0.0034316619858145714,
0.1491246223449707,
0.37090107798576355,
0.19700542092323303,
0.09594105929136276,
-0.4033958911895752,
0.11012711375951767,
-0.11151579022407532,
0.018008386716246605,
0.11399324238300323,
-0.014307141304016113,
0.30684366822242737,
0.07505378872156143,
0.025749312713742256,
-0.16711467504501343,
0.044929347932338715,
-0.04656700789928436,
0.22408682107925415,
-0.2040223628282547,
0.2873767912387848,
-0.3346622884273529,
-0.24082867801189423,
-0.3771361708641052,
-0.04883084446191788,
-0.13373541831970215,
-0.13293935358524323,
0.19477428495883942,
0.04998398199677467,
-0.03501645475625992,
-0.0062476471066474915,
0.019248701632022858,
0.22484271228313446,
0.0007652600179426372,
-0.31158268451690674,
0.04368092492222786,
0.3564395606517792,
0.2940729856491089,
-0.17827042937278748,
0.04616974666714668,
0.05796732380986214,
-0.09175640344619751,
0.07196003943681717,
-0.04063881188631058,
0.1664898693561554,
0.07679350674152374,
0.06736317276954651,
-0.03429948538541794,
-0.13251091539859772,
0.015952054411172867,
-0.35888054966926575,
0.002353971591219306,
0.037428393959999084,
-0.10346156358718872,
-0.24514494836330414,
0.2394273579120636,
-0.09585076570510864,
0.08574073016643524,
-0.1105533167719841,
0.12999825179576874,
-0.05496376380324364,
0.44271764159202576,
-0.04210585728287697,
-0.2906477749347687,
-0.09945357590913773,
-0.07122992724180222,
0.03662765771150589,
-0.0932120829820633,
-0.10040628165006638,
-0.2664419412612915,
0.20473313331604004,
0.23112717270851135,
0.13487938046455383,
0.034772586077451706,
0.22374354302883148,
0.06582067906856537,
0.2223948836326599,
0.08487185090780258,
0.01698814146220684,
-0.1920112520456314,
0.20201365649700165,
-0.15018916130065918,
0.05554186552762985,
0.1412360668182373,
0.044766753911972046,
-0.036503229290246964,
0.056794580072164536,
0.21077559888362885,
-0.07905782759189606,
0.02009766362607479,
0.04526421055197716,
-0.1199999675154686,
0.13621635735034943,
0.5669992566108704,
0.08463974297046661,
0.127182736992836,
-0.26189571619033813,
0.12886951863765717,
-0.09825856983661652,
0.25688397884368896,
0.30435940623283386,
-0.4110615849494934,
-0.019535798579454422,
-0.10051410645246506,
0.005734720733016729,
0.022840572521090508,
-0.14492139220237732,
0.20637984573841095,
0.08209109306335449,
-0.44121140241622925,
0.1412305384874344,
-0.16785506904125214,
0.1552654653787613,
0.16510525345802307,
0.10978598892688751,
0.1963951736688614,
-0.21967212855815887,
0.04662701115012169,
-0.260391503572464,
0.009561210870742798,
-0.1566324532032013,
0.07546399533748627,
-0.018055474385619164,
-0.10316649079322815,
0.17788776755332947,
-0.10558100789785385,
0.09260842949151993,
-0.030896823853254318,
-0.31554701924324036,
-0.08172431588172913,
-0.03198214992880821,
-0.5153583288192749,
-0.13940726220607758,
0.03195098042488098,
0.25361427664756775,
0.03582024201750755,
-0.008310489356517792,
-0.1364690065383911,
-0.15079277753829956,
0.05859110876917839,
-0.22038385272026062,
0.01645425334572792,
0.20844286680221558,
0.07926270365715027,
0.14503522217273712,
0.11141815781593323,
-0.1915324479341507,
-0.08322539180517197,
-0.030782360583543777,
-0.05940977856516838,
-0.1441212296485901,
-0.14996983110904694,
0.07954611629247665,
0.40881556272506714,
0.09904821962118149,
-0.06439391523599625,
0.2828189432621002,
-0.19025997817516327,
-0.13783235847949982,
0.1385016292333603,
0.2009272575378418,
-0.0716196820139885,
0.0438593253493309,
0.11676518619060516,
0.03633672744035721,
-0.006176768336445093,
0.09620988368988037,
0.29947853088378906,
-0.029795274138450623,
0.18783947825431824,
-0.004125389736145735,
-0.10418090969324112,
0.1630612462759018,
-0.11593437939882278,
0.14511390030384064,
-0.054040923714637756,
0.26333093643188477,
-0.2658355236053467,
-0.042549412697553635,
-0.18271906673908234,
0.21496836841106415,
-0.13152606785297394,
-0.17201043665409088,
-0.12864883244037628,
0.3119891285896301,
-0.28941234946250916,
0.3247629702091217,
-0.03375740721821785,
0.11402460932731628,
0.3052166700363159,
0.22299471497535706,
0.05341876670718193,
0.11366461962461472,
0.023412127047777176,
0.03153204172849655,
-0.07785823196172714,
-0.19252422451972961,
0.07601136714220047,
0.0018293655011802912,
-0.2499741017818451,
-0.005656266584992409,
0.28159457445144653,
0.3692447543144226,
-0.19218479096889496,
0.055605750530958176,
0.0745806023478508,
-0.02879640832543373,
0.13852176070213318,
0.19388796389102936,
-0.05559917166829109,
0.03906701132655144,
0.1301557719707489,
-0.05825301632285118,
0.023581691086292267,
-0.1774246096611023,
-0.17477460205554962,
0.10127042979001999,
-0.17421118915081024,
-0.07452062517404556,
0.16515739262104034,
0.15464788675308228,
0.19092583656311035,
-0.036727748811244965,
-0.33862391114234924,
0.18353670835494995,
-0.15520638227462769,
0.07125666737556458,
0.24208933115005493,
0.04561876505613327,
0.3830356299877167,
0.03581426292657852,
-0.0799633339047432,
0.11854719370603561,
-0.02114604227244854,
-0.0583220049738884,
-0.02995915897190571,
-0.026708627119660378,
0.11602731049060822,
0.07827798277139664,
0.14140893518924713,
0.14576362073421478,
0.027708714827895164,
0.35624176263809204,
0.221177339553833,
-0.26874810457229614,
0.18591730296611786,
0.15108157694339752,
0.003201840678229928,
-0.19070331752300262,
-0.03487624228000641,
0.08808135241270065,
0.027322029694914818,
-0.0043013691902160645,
0.4149077534675598,
-0.05254045128822327,
0.013105090707540512,
0.10089436918497086,
-0.04913894459605217,
-0.27518486976623535,
0.15853053331375122,
-0.1401337832212448,
0.23363207280635834,
-0.10377463698387146,
0.03625058755278587,
0.1955823451280594,
-0.03762524574995041,
0.21844471991062164,
-0.11312288045883179,
-0.23099207878112793,
0.01712276227772236,
-0.018035244196653366,
0.29462406039237976,
-0.12085609883069992,
0.0681297704577446,
-0.11983687430620193,
-0.15523122251033783,
0.30737942457199097,
0.2789545953273773,
0.15330104529857635,
0.39399150013923645,
-0.0058832489885389805,
-0.04830528050661087,
-0.1396571397781372,
-0.13995453715324402,
0.20062582194805145,
0.10434184223413467,
-0.2271415740251541,
0.11982671171426773,
-0.30651044845581055,
0.038093436509370804,
-0.1816864162683487,
-0.07195569574832916,
0.20284053683280945,
-0.023526979610323906,
-0.07314956933259964,
-0.005988197401165962,
-0.0012534145498648286,
-0.3606516420841217,
-0.15175028145313263,
-0.2079647183418274,
0.3085525929927826,
0.23770169913768768,
-0.0058158645406365395,
0.08388523757457733,
-0.019465431571006775,
0.3560905456542969,
-0.12811902165412903,
-0.05489003658294678,
0.14299555122852325,
-0.11779279261827469,
-0.26782676577568054,
0.197068989276886,
-0.12719592452049255,
-0.01186202373355627,
-0.014594960026443005,
0.42897701263427734,
0.15148234367370605,
0.2717086374759674,
-0.05365849658846855,
-0.06805110722780228,
-0.02770794741809368,
-0.0760183185338974,
0.04757290706038475,
-0.04662187397480011,
-0.3540322780609131,
-0.12742555141448975,
0.13142581284046173,
0.010201312601566315,
-0.12248783558607101,
-0.05527929589152336,
-0.002613897668197751,
-0.1679736077785492,
0.1996472179889679,
-0.0007503670640289783,
0.4022625982761383,
-0.009247752837836742,
-0.42278602719306946,
-0.18851257860660553,
-0.060245729982852936,
0.012756629846990108,
-0.15938156843185425,
0.1505344659090042,
0.34748074412345886,
0.13868536055088043,
-0.09085455536842346,
-0.12430303543806076,
0.017914270982146263,
0.3546367585659027,
0.12827715277671814,
-0.0657874122262001,
0.1176784411072731,
0.31524863839149475,
0.038734320551157,
-0.12653763592243195,
0.07610433548688889,
0.06568209826946259,
0.08859100937843323,
0.04269157722592354,
0.0407714806497097,
-0.18650488555431366,
0.0005091057973913848,
-0.09955380856990814,
-0.09332124143838882,
-0.029373910278081894,
0.20703284442424774,
0.24930846691131592,
-0.321031779050827,
0.09109356999397278,
-0.13750384747982025,
-0.08740942180156708,
-0.11264689266681671,
-0.06385296583175659,
-0.14678847789764404,
-0.21680694818496704,
-0.23730038106441498,
-0.3282671570777893,
-0.22253450751304626,
-0.03493978828191757,
-0.06986234337091446,
-0.13076281547546387,
-0.4153209924697876,
-0.10066795349121094,
-0.28124648332595825,
0.2352437674999237,
-0.25093984603881836,
0.061504773795604706,
0.4433634579181671,
0.11197341978549957,
0.19232262670993805,
-0.20313303172588348,
0.1046627014875412,
0.002977775875478983,
0.08340036123991013,
-0.1852475106716156,
-0.09584662318229675,
0.12440289556980133,
-0.11181265860795975,
-0.020873848348855972,
-0.04085212200880051,
-0.19512993097305298,
0.09476633369922638,
0.09256066381931305,
-0.15673820674419403,
0.4232560098171234,
0.23540258407592773,
0.0625770166516304,
-0.2151884287595749,
0.23498408496379852,
0.06101702153682709,
-0.3264758288860321,
-0.09769406169652939,
0.0649564191699028,
-0.01392124779522419,
0.19906578958034515,
-0.3565574288368225,
0.03975648432970047,
0.04492959380149841,
0.4012964069843292,
-0.10600613802671432,
0.4250279366970062,
0.013062343001365662,
0.20574399828910828,
0.21910513937473297,
-0.10982906073331833,
-0.02797798626124859,
-0.10161142796278,
0.1446632444858551,
0.26484647393226624,
-0.060879185795784,
0.2729761600494385,
-0.09319955110549927,
-0.016212960705161095,
0.28423234820365906,
0.09913518279790878,
0.13634668290615082,
-0.0895775705575943,
-0.3179117441177368,
-0.059166423976421356,
0.03207629919052124,
-0.09922728687524796,
-0.12908649444580078,
-0.04348771646618843,
0.14732690155506134,
-0.17649441957473755,
0.0026932358741760254,
0.19029544293880463,
-0.28545400500297546,
-0.20793892443180084,
-0.08777667582035065,
-0.09574159979820251,
0.2997061610221863,
0.1501363068819046,
0.04031410440802574,
-0.2431078404188156,
-0.2679034471511841,
0.3833657205104828,
0.06800007075071335,
-0.15416382253170013,
-0.13448718190193176,
-0.07264736294746399,
-0.13242366909980774,
0.028286121785640717,
0.014478122815489769,
0.04483203962445259,
0.14444288611412048,
-0.013867723755538464,
-0.0727413073182106,
-0.16422758996486664,
0.07010648399591446,
-0.16533620655536652,
0.1330711394548416,
0.14204028248786926,
0.12476111203432083,
-0.04164932668209076,
-0.21269448101520538,
0.2330217957496643,
0.11055365204811096,
0.07621888071298599,
0.06571737676858902,
0.25297924876213074,
-0.3032260835170746,
-0.1543756127357483,
0.023527152836322784,
0.213660329580307,
-0.07653802633285522,
0.20119811594486237,
-0.09125921130180359,
0.05866965278983116,
-0.09634923934936523,
0.08009739220142365,
0.15149077773094177,
-0.0035797464661300182,
0.10781732201576233,
0.03260273113846779,
-0.13151085376739502,
0.4065553843975067,
-0.058987125754356384,
0.21532802283763885,
-0.08243662118911743,
0.08227097988128662,
0.059622567147016525,
-0.06475309282541275,
0.27613046765327454,
0.07702309638261795,
-0.40097981691360474,
-0.07881473749876022,
0.044210996478796005,
0.2691272497177124,
-0.12371733784675598,
-0.08525872230529785,
0.03368514031171799,
-0.24204596877098083,
0.0384104922413826,
-0.3292159140110016,
0.204874187707901,
-0.14715629816055298,
0.01791680045425892,
0.018180517479777336,
-0.030774258077144623,
-0.092318095266819,
0.08032790571451187,
-0.26252976059913635,
0.05207335576415062,
-0.08547020703554153,
0.01212739571928978,
-0.6090254187583923,
0.2052498608827591,
0.2710493803024292,
-0.18639697134494781,
-0.10166385024785995,
-0.397028386592865,
-0.3885306119918823,
-0.1350105255842209,
0.04783454164862633,
0.0009074751869775355,
0.015216141939163208,
-0.007630448322743177,
-0.1091519370675087,
-0.22664311528205872,
0.018228674307465553,
-0.1407008022069931,
-0.043364621698856354,
0.0017221096204593778,
0.21361689269542694,
0.07590112090110779,
-0.0783621221780777,
0.04642688110470772,
-0.1442442387342453,
-0.17901991307735443,
0.07875985652208328,
-0.1628529280424118,
0.02879188396036625,
-0.02922605723142624,
-0.1485268920660019,
-0.20306707918643951,
0.10645005851984024,
-0.3675313889980316,
0.1089244931936264,
0.029093047603964806,
-0.13742288947105408,
-0.2827339172363281,
-0.04270961880683899,
0.1584504395723343,
0.3545233905315399,
0.05104346573352814,
-0.09724217653274536,
0.20128145813941956
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. for these disorders. The authors recommend hematologic evaluation and consultation for consideration of anticoagulant prophylaxis for individuals undergoing surgery or other procedures that may predispose to DVT/PE.Tumors. It is impractical to screen for tumors with imaging in individuals with PS because the tumors are so heterogeneous. Instead, a primary care clinician should evaluate the individuals regularly (every 6-12 months) and elicit signs and symptoms of malignancy (e.g., pain, unexpected growths, signs of obstruction or compression). If these are elicited, an imaging evaluation of that organ system should be undertaken.Bullous pulmonary disease. Pulmonary evaluation is recommended for individuals with bullous pulmonary disease, and resection of large bullous lesions may be indicated in some individuals. Bullous disease in the context of scoliosis can pose significant and complex challenges for appropriate management.Psychometric and learning evaluation. Developmental evaluation for consideration of intervention or special education for those individuals with developmental delays is indicated.Psychosocial issues. Psychosocial counseling is certainly warranted in most instances. | [
-0.12699104845523834,
-0.11405511945486069,
-0.07965423166751862,
-0.3097974359989166,
0.11262529343366623,
-0.013819057494401932,
-0.16991731524467468,
-0.03897237032651901,
-0.09976924955844879,
0.0177757665514946,
0.300106406211853,
-0.014992395415902138,
-0.07258401066064835,
-0.04176239296793938,
-0.19703157246112823,
0.17313522100448608,
-0.025352586060762405,
-0.1355995535850525,
0.13409340381622314,
0.07850677520036697,
0.05641867220401764,
-0.10207600891590118,
-0.04420924931764603,
-0.008531566709280014,
0.004437554161995649,
-0.18143779039382935,
0.1473989486694336,
0.12581945955753326,
0.021578626707196236,
-0.1310678869485855,
-0.24552468955516815,
0.0478743240237236,
-0.1715204417705536,
-0.23853375017642975,
-0.021540289744734764,
-0.3201381266117096,
-0.28526440262794495,
0.04346160963177681,
-0.052195955067873,
0.09175035357475281,
-0.14694394171237946,
-0.04912214353680611,
0.10290186107158661,
-0.07796621322631836,
0.08630920946598053,
-0.016329364851117134,
0.11084537953138351,
-0.0012994060525670648,
0.02408398501574993,
0.21106161177158356,
-0.002961592050269246,
0.045121222734451294,
0.0721452459692955,
-0.12314806133508682,
0.018825886771082878,
-0.18062137067317963,
0.04182581230998039,
-0.08744657039642334,
-0.26413238048553467,
0.07079629600048065,
0.2478620857000351,
-0.0023479843512177467,
0.029753288254141808,
-0.30596309900283813,
0.03932690620422363,
-0.12805044651031494,
-0.10759246349334717,
0.06602004915475845,
0.21909423172473907,
-0.10341814160346985,
0.2641965448856354,
0.047276344150304794,
-0.11862709373235703,
0.06434129923582077,
-0.018140267580747604,
0.03587719798088074,
0.003565005259588361,
-0.05533995479345322,
0.15233656764030457,
-0.3221810460090637,
-0.08407767117023468,
-0.04233311489224434,
-0.02784537523984909,
0.017776574939489365,
-0.21392273902893066,
-0.0963284894824028,
0.01814560405910015,
0.044137194752693176,
-0.031672969460487366,
0.01023211982101202,
-0.014573311433196068,
-0.0023450246080756187,
0.013312965631484985,
0.23121093213558197,
0.1632215678691864,
-0.19885599613189697,
0.25715407729148865,
0.15102705359458923,
-0.04468264803290367,
0.029986422508955002,
0.06807591021060944,
0.2502593398094177,
0.05479511618614197,
-0.10601291805505753,
0.16146068274974823,
-0.014524372294545174,
-0.06286773085594177,
-0.10228683799505234,
0.1066867783665657,
-0.08654852211475372,
0.006585746072232723,
0.12002065032720566,
0.06946320831775665,
-0.13609980046749115,
-0.15129195153713226,
-0.12342234700918198,
0.11432196944952011,
0.06239856034517288,
-0.19128648936748505,
-0.034164607524871826,
-0.08467535674571991,
0.00812617503106594,
0.056227654218673706,
-0.165358766913414,
0.22599290311336517,
0.037614405155181885,
0.27102500200271606,
-0.26891979575157166,
0.01194809004664421,
0.009861523285508156,
0.1054675281047821,
-0.14152441918849945,
-0.011598278768360615,
-0.16473110020160675,
-0.054493919014930725,
0.0612519308924675,
-0.03140517324209213,
-0.15927232801914215,
0.022763682529330254,
0.08641232550144196,
0.11887340992689133,
0.16948038339614868,
0.2700592577457428,
0.1757017821073532,
-0.14058060944080353,
0.013395179063081741,
0.21421614289283752,
0.01485490519553423,
0.023196114227175713,
-0.026579374447464943,
0.10554861277341843,
-0.177387997508049,
0.1497086137533188,
0.10057768225669861,
0.06001086160540581,
-0.056750401854515076,
0.005066056735813618,
0.23909404873847961,
-0.06553374230861664,
-0.049351766705513,
-0.05381283536553383,
-0.16928866505622864,
-0.05003547668457031,
0.018357882276177406,
0.07144671678543091,
0.0908840075135231,
0.08178425580263138,
-0.02666003257036209,
0.10403385013341904,
-0.13734851777553558,
-0.07293512672185898,
-0.00012206442625029013,
-0.06437185406684875,
0.21694748103618622,
-0.05052434280514717,
0.16141676902770996,
0.04865919053554535,
0.10969971865415573,
-0.050005953758955,
0.11543064564466476,
0.0331188403069973,
-0.2545504868030548,
-0.039051298052072525,
-0.07525652647018433,
0.018004192039370537,
-0.09463197737932205,
-0.03865634277462959,
0.09357525408267975,
-0.1091131791472435,
0.24066834151744843,
0.13508667051792145,
-0.04247923940420151,
-0.18575309216976166,
-0.018346285447478294,
-0.05653611570596695,
-0.22849415242671967,
-0.03726833686232567,
-0.0188737865537405,
0.048599645495414734,
0.05316586792469025,
0.027035171166062355,
0.04204592853784561,
0.03701136261224747,
-0.0648258626461029,
0.10610010474920273,
0.05649065598845482,
0.10137132555246353,
-0.20521430671215057,
0.22568723559379578,
0.04016181081533432,
0.012761558406054974,
0.2957644760608673,
-0.07689791917800903,
-0.00626787357032299,
0.0529724583029747,
-0.05846932530403137,
-0.24515873193740845,
-0.13075250387191772,
-0.13888655602931976,
0.19499167799949646,
-0.3338146507740021,
0.09431180357933044,
-0.051051635295152664,
-0.14859700202941895,
-0.21949763596057892,
-0.08778806775808334,
-0.03141558915376663,
-0.07789760082960129,
0.11413659155368805,
0.015228440053761005,
-0.08395349234342575,
0.008428997360169888,
0.04217112436890602,
0.17139874398708344,
0.11947400867938995,
-0.28192076086997986,
-0.20005786418914795,
0.35614097118377686,
0.08414677530527115,
0.025572530925273895,
0.12930898368358612,
-0.09146633744239807,
0.11493750661611557,
-0.04880155622959137,
-0.04804277792572975,
0.1265244334936142,
0.08514281362295151,
0.18791940808296204,
-0.1685749739408493,
-0.0076551358215510845,
0.016145378351211548,
-0.13878314197063446,
0.03786851465702057,
0.036703161895275116,
-0.12694907188415527,
-0.09151244163513184,
0.07327982783317566,
-0.09658783674240112,
0.07706930488348007,
-0.0028052199631929398,
-0.0015778887318447232,
0.025340816006064415,
0.35355144739151,
-0.16254541277885437,
-0.2924155592918396,
-0.11208902299404144,
0.06698830425739288,
0.10366745293140411,
-0.12573811411857605,
-0.14208699762821198,
-0.08513304591178894,
0.19196635484695435,
-0.012545590288937092,
-0.02629246935248375,
0.014165614731609821,
0.06856764853000641,
-0.11485955864191055,
0.09289667755365372,
0.15307700634002686,
0.168067067861557,
0.10786654055118561,
0.03598006069660187,
-0.09108162671327591,
-0.023896535858511925,
0.20343723893165588,
0.10267309099435806,
-0.17466822266578674,
0.11709030717611313,
0.009170598350465298,
-0.0035411883145570755,
0.2263956218957901,
0.037868160754442215,
-0.06469140946865082,
0.030040554702281952,
0.12209752202033997,
0.19516414403915405,
0.05898699909448624,
0.05053179711103439,
-0.034990452229976654,
-0.1775171011686325,
0.10570082068443298,
0.3416880965232849,
-0.2251092791557312,
-0.04324736073613167,
-0.1000443622469902,
-0.1512628197669983,
0.0561680905520916,
-0.21062906086444855,
0.06567774713039398,
-0.007912238128483295,
-0.13177402317523956,
0.21230334043502808,
-0.1473907083272934,
0.07480056583881378,
-0.005239705089479685,
-0.002590482821688056,
-0.15740136802196503,
-0.0684879943728447,
0.06251055002212524,
-0.11427776515483856,
0.007739090360701084,
-0.14484499394893646,
0.06143353879451752,
0.12663541734218597,
-0.07391773164272308,
-0.019940583035349846,
0.012756469659507275,
0.17380979657173157,
-0.04471872001886368,
-0.08765818178653717,
-0.1043732538819313,
0.002400565892457962,
-0.23689092695713043,
-0.10159528255462646,
0.000896208337508142,
-0.10762721300125122,
0.2204815298318863,
-0.02238411270081997,
-0.0936436727643013,
-0.16753733158111572,
-0.03755845129489899,
-0.21763089299201965,
0.11709856241941452,
-0.013690724037587643,
-0.06263098865747452,
0.14021332561969757,
0.1344061940908432,
0.038179926574230194,
-0.0350969098508358,
-0.01219477504491806,
-0.04745664447546005,
-0.3309039771556854,
0.10565657168626785,
-0.30948692560195923,
0.07624563574790955,
0.06708215922117233,
0.06719809025526047,
0.05946725234389305,
-0.10839412361383438,
0.06735918670892715,
-0.09932660311460495,
-0.023779332637786865,
-0.09072212874889374,
-0.22570854425430298,
0.05857280269265175,
0.010938145220279694,
-0.1695426106452942,
0.007393163628876209,
0.39852991700172424,
0.038428548723459244,
0.3147973418235779,
0.12709692120552063,
0.05904717370867729,
-0.15663954615592957,
-0.05044097825884819,
0.013468961231410503,
-0.14804816246032715,
0.019891012459993362,
-0.2552778422832489,
-0.16116590797901154,
-0.0793657973408699,
-0.010108365677297115,
0.09150081127882004,
-0.12643024325370789,
-0.07133431732654572,
0.10684976726770401,
-0.28939324617385864,
0.27534210681915283,
-0.10697779804468155,
-0.042251598089933395,
0.23913829028606415,
-0.0496363639831543,
0.0732530951499939,
0.0657152310013771,
0.04088104888796806,
-0.010916150175035,
0.11783544719219208,
-0.1370290070772171,
-0.1388607770204544,
0.00898715015500784,
0.023323573172092438,
0.007308044470846653,
0.15891633927822113,
0.08805299550294876,
-0.025213638320565224,
-0.12352653592824936,
0.008494501933455467,
0.05917363986372948,
-0.13816116750240326,
0.20744235813617706,
-0.11602093279361725,
0.009855338372290134,
0.07959920912981033,
-0.013645856641232967,
-0.03369109332561493,
-0.09442263096570969,
-0.15733321011066437,
-0.013473409228026867,
0.006817914545536041,
-0.23023632168769836,
0.053613584488630295,
-0.1321043223142624,
0.030607065185904503,
-0.043500740081071854,
-0.22018054127693176,
0.06588238477706909,
-0.09923121333122253,
0.09390828013420105,
0.08142079412937164,
0.16265709698200226,
0.3329363763332367,
0.013584580272436142,
-0.11957315355539322,
0.16713599860668182,
-0.012317442335188389,
0.046796418726444244,
0.03243309631943703,
0.18279299139976501,
0.17447741329669952,
-0.08182915300130844,
0.3085114061832428,
-0.13797608017921448,
0.24471499025821686,
0.16595271229743958,
0.031792424619197845,
-0.0903325304389,
0.005509078036993742,
0.18127870559692383,
0.021493788808584213,
0.032014090567827225,
-0.009345492348074913,
0.002997789764776826,
0.08280310779809952,
-0.00556614063680172,
0.0793294683098793,
0.09903975576162338,
-0.07923204451799393,
0.019596917554736137,
-0.09596118330955505,
-0.01509286742657423,
-0.135614275932312,
-0.011212966404855251,
0.06097351387143135,
0.10797597467899323,
-0.06607218831777573,
0.12238286435604095,
-0.20157396793365479,
0.09327642619609833,
0.01650608517229557,
0.06737831234931946,
-0.0017986645689234138,
0.02032301016151905,
0.12260321527719498,
0.09131469577550888,
-0.10454139858484268,
-0.22579552233219147,
-0.06475719809532166,
0.11220384389162064,
-0.05755958706140518,
0.1858488768339157,
0.20704194903373718,
0.028890149667859077,
-0.06947572529315948,
-0.057451196014881134,
0.04000958800315857,
0.022189218550920486,
0.06443572044372559,
-0.12609466910362244,
0.23279470205307007,
-0.17582271993160248,
0.13486513495445251,
-0.012800619937479496,
-0.03763394057750702,
0.26504477858543396,
0.029092971235513687,
-0.05578623339533806,
0.13653424382209778,
-0.051137905567884445,
-0.054216351360082626,
-0.03343886137008667,
0.0753290057182312,
0.19601970911026,
0.012288812547922134,
0.018299395218491554,
-0.01404156256467104,
0.07618777453899384,
0.11640802025794983,
-0.17663826048374176,
-0.27832120656967163,
0.1088513731956482,
-0.13166408240795135,
0.010843542404472828,
0.015072382986545563,
-0.0915193110704422,
0.06393183022737503,
0.02468728832900524,
0.08081373572349548,
0.24151265621185303,
0.12959903478622437,
0.004298127256333828,
0.14111395180225372,
-0.008901290595531464,
0.04968938231468201,
0.08584289252758026,
-0.03677169233560562,
-0.02693849615752697,
0.08912137895822525,
0.12738832831382751,
-0.05001271143555641,
-0.1359989494085312,
-0.15018045902252197,
-0.1376984566450119,
0.04484358802437782,
-0.012260678224265575,
0.09236788749694824,
0.050736550241708755,
-0.01953849196434021,
0.01544967945665121,
-0.3207773268222809,
0.08286716043949127,
-0.2063187062740326,
0.11958964169025421,
0.10462135076522827,
0.036641765385866165,
0.0006607343093492091,
0.022059228271245956,
-0.032507430762052536,
-0.002149829175323248,
0.1346740424633026,
0.2190096229314804,
0.1481877565383911,
0.027553962543606758,
0.07587237656116486,
-0.02555024065077305,
0.01964588463306427,
-0.016825303435325623,
0.17239342629909515,
0.15415211021900177,
-0.0063817985355854034,
0.357469767332077,
-0.066122867166996,
0.056803274899721146,
0.06704912334680557,
-0.06704967468976974,
0.03918422758579254,
0.24184280633926392,
0.20878873765468597,
-0.16313931345939636,
-0.057752009481191635,
0.06500127911567688,
-0.06985603272914886,
-0.14664147794246674,
0.059219613671302795,
-0.16450610756874084,
-0.004646570887416601,
0.0022240160033106804,
-0.10567303746938705,
-0.09130082279443741,
-0.1560865342617035,
0.12271059304475784,
0.13249044120311737,
-0.12489583343267441,
-0.10957054048776627,
-0.2877312898635864,
0.12614655494689941,
0.043438997119665146,
-0.15406177937984467,
0.21852166950702667,
0.16797707974910736,
0.08046993613243103,
-0.13713596761226654,
-0.12267692387104034,
0.09248141199350357,
-0.13476106524467468,
0.0380764976143837,
-0.16396774351596832,
0.12586034834384918,
-0.013818886131048203,
-0.18187183141708374,
-0.09703352302312851,
-0.08783312886953354,
0.033475954085588455,
-0.06590461730957031,
-0.2626369595527649,
-0.039384275674819946,
0.004904964938759804,
0.00787751842290163,
-0.09372847527265549,
0.23495593667030334,
-0.11902904510498047,
-0.19648900628089905,
-0.028708025813102722,
0.07378673553466797,
0.029295679181814194,
0.22645634412765503,
-0.2709401249885559,
0.0377616286277771,
-0.012748677283525467,
0.027918890118598938,
-0.13825078308582306,
0.30141353607177734,
0.028305932879447937,
0.045287732034921646,
-0.024629028514027596,
0.04957858473062515,
0.19373385608196259,
-0.032159000635147095,
0.08643106371164322,
-0.024995742365717888,
-0.1581113189458847,
0.036919184029102325,
-0.15896005928516388,
-0.027668872848153114,
-0.009784240275621414,
-0.007746475748717785,
-0.046024590730667114,
-0.03840525075793266,
-0.22499805688858032,
-0.02374611422419548,
0.012889605946838856,
-0.07194557040929794,
0.01965791918337345,
-0.06941396743059158,
0.2297392189502716,
-0.2402152419090271,
-0.013845264911651611,
0.13460908830165863,
-0.2761169970035553,
-0.13196691870689392,
-0.13438868522644043,
-0.08189904689788818,
0.10208170115947723,
0.272592157125473,
-0.12978389859199524,
0.03329305723309517,
-0.04928296431899071,
0.2707262337207794,
0.12591297924518585,
-0.025648918002843857,
-0.0035904566757380962,
-0.0646321251988411,
-0.022844059392809868,
-0.15881022810935974,
-0.05670026317238808,
0.1696833372116089,
0.1302444338798523,
-0.06140637770295143,
0.15167905390262604,
-0.11335750669240952,
-0.11638330668210983,
-0.015915177762508392,
0.20458069443702698,
0.1151660606265068,
0.09843505173921585,
0.01692998968064785,
0.04731298238039017,
0.14507226645946503,
-0.2006019800901413,
-0.006606539711356163,
0.22376549243927002,
0.09553986042737961,
-0.29055795073509216,
-0.04061034694314003,
-0.21647986769676208,
0.12157781422138214,
-0.13457046449184418,
-0.13131183385849,
-0.07523220032453537,
0.08782050758600235,
0.03490491583943367,
-0.06550560146570206,
-0.10732561349868774,
-0.03201710805296898,
0.013799339532852173,
0.033359114080667496,
-0.06589719653129578,
0.32719823718070984,
-0.12449107319116592,
0.06474999338388443,
-0.16155576705932617,
0.16028736531734467,
-0.041603777557611465,
-0.036507461220026016,
0.10145721584558487,
0.15932758152484894,
-0.16911035776138306,
-0.03248361498117447,
-0.14333230257034302,
0.11604656279087067,
-0.11492472141981125,
-0.060811251401901245,
0.032525379210710526,
-0.09519804269075394,
0.18602706491947174,
-0.11592575162649155,
0.21850135922431946,
-0.19214603304862976,
0.1523476392030716,
0.025299007073044777,
-0.0620344877243042,
0.026788625866174698,
0.18079343438148499,
-0.12107925862073898,
-0.022731253877282143,
0.1787077635526657,
0.011974560096859932,
-0.07168878614902496,
0.07965385168790817,
-0.011519331485033035,
-0.07411845028400421,
-0.1583447903394699,
-0.2402290403842926,
-0.2602900266647339,
-0.07683103531599045,
-0.005981779191643,
-0.01289532333612442,
0.06414027512073517,
-0.10886993259191513,
-0.029877919703722,
-0.02324717678129673,
0.06633512675762177,
-0.09503965824842453,
0.08024735748767853,
0.11204686760902405,
0.12917320430278778,
-0.037633128464221954,
0.03029732033610344,
-0.13230463862419128,
-0.09741149097681046,
-0.1312568336725235,
0.018282519653439522,
-0.08638294041156769,
0.041581444442272186,
0.031798407435417175,
-0.19477522373199463,
-0.30178892612457275,
-0.1046137660741806,
-0.16377252340316772,
0.05137931555509567,
0.0773516297340393,
-0.07721099257469177,
-0.04383542388677597,
0.017629651352763176,
0.012031284160912037,
-0.0934632420539856,
0.07264139503240585,
-0.013202810660004616,
0.13288749754428864
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. or compression). If these are elicited, an imaging evaluation of that organ system should be undertaken.Bullous pulmonary disease. Pulmonary evaluation is recommended for individuals with bullous pulmonary disease, and resection of large bullous lesions may be indicated in some individuals. Bullous disease in the context of scoliosis can pose significant and complex challenges for appropriate management.Psychometric and learning evaluation. Developmental evaluation for consideration of intervention or special education for those individuals with developmental delays is indicated.Psychosocial issues. Psychosocial counseling is certainly warranted in most instances. Although PS is exceedingly rare, a robust support group infrastructure exists and many families find this very helpful (see Resources).SurveillanceIndividualized surveillance plans for the skeletal, pulmonary, soft-tissue, and other manifestations of PS should be developed according to the individual's specific needs.Because of the predisposition to a range of tumors (most of which are benign) individuals with PS should be monitored by their primary care provider with regular evaluations including a directed medical history and examination; | [
-0.2016768902540207,
-0.07630395889282227,
-0.015702998265624046,
-0.17210038006305695,
0.15717129409313202,
-0.049012504518032074,
-0.09303463995456696,
-0.08529654145240784,
-0.18124812841415405,
0.11923559010028839,
0.2903987169265747,
-0.020754331722855568,
-0.07230794429779053,
-0.05578988790512085,
-0.2378038913011551,
0.08894407004117966,
0.062294866889715195,
-0.13744179904460907,
0.041470784693956375,
0.08648236095905304,
0.03459269925951958,
-0.09744484722614288,
-0.006469422951340675,
-0.04242882877588272,
0.14305175840854645,
-0.1650574803352356,
0.046276554465293884,
-0.0160320233553648,
0.05997328460216522,
-0.20150230824947357,
-0.17923352122306824,
0.010477225296199322,
-0.13044610619544983,
-0.17446011304855347,
0.09584223479032516,
-0.33396008610725403,
-0.25555214285850525,
0.022492539137601852,
-0.015258760191500187,
0.082016222178936,
-0.08159482479095459,
-0.01871388591825962,
0.14512290060520172,
-0.05523679777979851,
0.1450834572315216,
0.020808959379792213,
0.1422051042318344,
-0.045548319816589355,
0.0524253323674202,
0.1271737962961197,
-0.10627428442239761,
-0.05865870788693428,
0.037157092243433,
-0.08304795622825623,
-0.05616317316889763,
-0.3021673858165741,
0.09733689576387405,
-0.08955514430999756,
-0.2317647635936737,
0.01083159726113081,
0.2623228430747986,
-0.02561461366713047,
-0.002226640470325947,
-0.2833891212940216,
0.13170871138572693,
-0.16159740090370178,
-0.12884797155857086,
-0.01823943294584751,
0.1258205771446228,
-0.12967097759246826,
0.2824035584926605,
-0.001117895939387381,
-0.08404267579317093,
0.1654437780380249,
-0.09774937480688095,
-0.09918930381536484,
-0.06550467759370804,
-0.07076479494571686,
0.12750142812728882,
-0.31023749709129333,
-0.13374394178390503,
-0.02017028257250786,
-0.015590149909257889,
-0.027804022654891014,
-0.17830295860767365,
-0.14793047308921814,
-0.014511248096823692,
0.14628863334655762,
0.027241356670856476,
-0.01708213984966278,
0.0944996103644371,
-0.030942825600504875,
0.03926673159003258,
0.24039357900619507,
0.06732102483510971,
-0.21417993307113647,
0.2513144016265869,
0.18215863406658173,
-0.11731354147195816,
-0.010292899794876575,
0.06314875930547714,
0.2885773777961731,
0.10531961917877197,
-0.05440358445048332,
0.136691614985466,
-0.08845420926809311,
-0.17666319012641907,
-0.01702677644789219,
0.14394183456897736,
-0.10538654774427414,
0.002407622756436467,
0.05252188816666603,
0.13526152074337006,
-0.10686278343200684,
-0.16607406735420227,
-0.06886523216962814,
0.07889431715011597,
0.08814093470573425,
-0.2072737216949463,
-0.056738220155239105,
0.011722534894943237,
0.02296610362827778,
0.10997948795557022,
-0.14277386665344238,
0.26149502396583557,
0.016538776457309723,
0.3274839222431183,
-0.26546710729599,
-0.022147152572870255,
-0.11776864528656006,
0.14286117255687714,
-0.1341775506734848,
-0.10662762075662613,
-0.26702359318733215,
-0.06146390363574028,
0.04777812585234642,
-0.0681694820523262,
-0.25169482827186584,
-0.00739788543432951,
0.12869063019752502,
0.04052302986383438,
0.18328721821308136,
0.2556593120098114,
0.1168811246752739,
-0.06220109015703201,
0.07739047706127167,
0.22669009864330292,
-0.021284274756908417,
0.017544960603117943,
-0.08155295252799988,
0.08267109841108322,
-0.1304936408996582,
0.12631350755691528,
0.09103535860776901,
0.16735617816448212,
-0.03689287602901459,
0.022671569138765335,
0.30979058146476746,
-0.06471941620111465,
0.04507048800587654,
-0.02805311605334282,
-0.22454027831554413,
-0.11490923166275024,
-0.05534219369292259,
-0.03480234742164612,
0.12144619971513748,
0.10844433307647705,
-0.031777385622262955,
0.08283349126577377,
-0.12209759652614594,
-0.013826760463416576,
0.01731906272470951,
-0.10513416677713394,
0.26331818103790283,
-0.014353346079587936,
0.21680228412151337,
0.1035080999135971,
0.06158149242401123,
0.06242213025689125,
0.22961845993995667,
0.11235806345939636,
-0.3212134838104248,
-0.12570375204086304,
-0.04231873154640198,
0.025719119235873222,
-0.11390281468629837,
-0.05202799662947655,
0.08666301518678665,
-0.06735692173242569,
0.20412811636924744,
0.1394663006067276,
0.05402505770325661,
-0.14827321469783783,
0.005656017456203699,
0.05911010876297951,
-0.2946739196777344,
-0.04264334961771965,
0.03271041810512543,
-0.03058558516204357,
0.026845019310712814,
0.00019092291768174618,
-0.05821593850851059,
0.14671823382377625,
-0.04820261523127556,
0.08043630421161652,
0.06149516627192497,
0.09763631224632263,
-0.2172427624464035,
0.2636374235153198,
0.06231037154793739,
-0.06853099912405014,
0.2803107798099518,
-0.13709399104118347,
0.05171024426817894,
0.0016479722689837217,
-0.07674368470907211,
-0.2433214634656906,
-0.14770254492759705,
-0.323577344417572,
0.18077689409255981,
-0.34029412269592285,
0.09770920127630234,
-0.09358343482017517,
-0.16068854928016663,
-0.21139925718307495,
-0.06049956753849983,
-0.06322506815195084,
-0.05655693635344505,
0.15893131494522095,
-0.07413771748542786,
-0.06605596095323563,
-0.0031002608593553305,
0.09235534071922302,
0.23463477194309235,
0.04700707644224167,
-0.25339946150779724,
-0.14286167919635773,
0.3050118684768677,
0.09142255038022995,
0.08084028959274292,
0.14175178110599518,
-0.14539341628551483,
0.11660315096378326,
-0.06450161337852478,
0.033923257142305374,
0.13914211094379425,
0.07971924543380737,
0.21298176050186157,
-0.1685400903224945,
0.022947324439883232,
-0.022620590403676033,
-0.08266548067331314,
0.065811388194561,
0.01973920501768589,
-0.11858343333005905,
-0.03314265236258507,
-0.02405417710542679,
-0.18997904658317566,
0.12237178534269333,
0.00038630684139207006,
-0.03318467363715172,
-0.04170842841267586,
0.47116121649742126,
-0.1213536188006401,
-0.22986558079719543,
-0.15376363694667816,
0.09860479086637497,
0.14523974061012268,
-0.07842877507209778,
-0.19393450021743774,
-0.17157112061977386,
0.12381628155708313,
-0.006793068256229162,
0.020144784823060036,
-0.012179095298051834,
0.06409760564565659,
-0.0727548748254776,
0.05437605082988739,
0.2063474953174591,
0.15166075527668,
0.17646613717079163,
0.05409228429198265,
-0.029503120109438896,
-0.020348917692899704,
0.17759083211421967,
0.048597801476716995,
-0.14836306869983673,
0.2189524918794632,
0.01379373949021101,
-0.012387663125991821,
0.28201302886009216,
-0.03152235969901085,
-0.022317390888929367,
0.13788118958473206,
0.053221963346004486,
0.22710134088993073,
0.07944287359714508,
0.0940374955534935,
-0.035083040595054626,
-0.17424002289772034,
0.11660963296890259,
0.293354332447052,
-0.28248298168182373,
-0.09708850830793381,
-0.12058757245540619,
-0.11350971460342407,
0.10191281884908676,
-0.2135031819343567,
0.09049927443265915,
0.051083046942949295,
-0.06057319417595863,
0.023012200370430946,
-0.1651936024427414,
0.15262027084827423,
0.09676999598741531,
-0.002083615167066455,
-0.214717835187912,
0.010100889019668102,
0.1500195860862732,
-0.0848589539527893,
0.039930764585733414,
-0.2216513454914093,
0.0377819761633873,
0.11552263051271439,
-0.0991145670413971,
0.05195292830467224,
0.06130241975188255,
0.19355285167694092,
-0.04309369996190071,
-0.12502197921276093,
-0.18330875039100647,
0.07236601412296295,
-0.1635119915008545,
-0.11011366546154022,
0.007429518736898899,
-0.0655774250626564,
0.28852489590644836,
-0.05531687289476395,
0.019583413377404213,
-0.1087324470281601,
-0.008901768364012241,
-0.2444288432598114,
0.006295901257544756,
-0.04207209497690201,
-0.03345562517642975,
0.17791911959648132,
0.11966709792613983,
-0.01825236715376377,
-0.001528511056676507,
-0.033720359206199646,
-0.12128417193889618,
-0.31288427114486694,
0.046372875571250916,
-0.38658398389816284,
0.14203381538391113,
0.10937435925006866,
0.11966659128665924,
0.06655564159154892,
-0.10539805889129639,
0.1198667362332344,
-0.10783225297927856,
-0.06281107664108276,
-0.1196834072470665,
-0.2378319799900055,
0.0436292365193367,
0.0653965175151825,
-0.16593506932258606,
0.04100760072469711,
0.4181399643421173,
0.028592102229595184,
0.3422096073627472,
0.10381003469228745,
0.029399704188108444,
-0.07354152202606201,
-0.04360834136605263,
0.026331795379519463,
-0.18932969868183136,
-0.03091728314757347,
-0.3227411210536957,
-0.284292072057724,
-0.02299681305885315,
0.013370099477469921,
0.07387309521436691,
-0.1456238031387329,
-0.11415204405784607,
0.02173512428998947,
-0.20086179673671722,
0.2334025651216507,
-0.1387704312801361,
-0.022353898733854294,
0.23061677813529968,
-0.02652541734278202,
0.10826177150011063,
0.05732142552733421,
0.038618847727775574,
0.054946571588516235,
0.13115088641643524,
-0.10643013566732407,
-0.09865357726812363,
-0.022462232038378716,
-0.013246733695268631,
-0.03141665458679199,
0.24507181346416473,
0.14097674190998077,
0.03957652673125267,
-0.15691161155700684,
-0.05577783286571503,
-0.055582888424396515,
-0.16735440492630005,
0.22448992729187012,
-0.08850333094596863,
-0.01082612108439207,
0.07403244823217392,
-0.03557807579636574,
0.02112150378525257,
0.021080851554870605,
-0.15822888910770416,
0.033475134521722794,
-0.012013910338282585,
-0.15672621130943298,
0.06378992646932602,
-0.17194893956184387,
0.012603369541466236,
0.06900521367788315,
-0.233989417552948,
0.047348879277706146,
-0.18447449803352356,
0.13969548046588898,
0.008703694678843021,
0.17250487208366394,
0.2738173007965088,
0.012632964178919792,
-0.1083977147936821,
0.24362681806087494,
0.036723792552948,
0.10672765225172043,
0.016523992642760277,
0.14596974849700928,
0.13335822522640228,
-0.020537322387099266,
0.2119619995355606,
-0.17698612809181213,
0.26109451055526733,
0.1727542281150818,
0.011029464192688465,
-0.10208526998758316,
0.015657374635338783,
0.14457562565803528,
0.0463988333940506,
0.04555252194404602,
-0.0919208750128746,
-0.07490186393260956,
0.14333917200565338,
-0.015012318268418312,
0.10555920004844666,
0.10368108749389648,
-0.04068677872419357,
-0.030433064326643944,
-0.111800916492939,
0.02834182418882847,
-0.1757759302854538,
-0.055426448583602905,
-0.012529143132269382,
0.10168419778347015,
-0.032587576657533646,
0.12560443580150604,
-0.2358020842075348,
0.04052560403943062,
0.06309852004051208,
0.071562260389328,
0.10293179005384445,
0.007889668457210064,
0.10571950674057007,
0.14415374398231506,
-0.0689767524600029,
-0.2383490949869156,
-0.016085365787148476,
0.05247059464454651,
-0.13849933445453644,
0.22901740670204163,
0.19561024010181427,
0.03060324862599373,
-0.03508911654353142,
-0.07398850470781326,
0.11698278784751892,
0.1451704204082489,
0.09090600162744522,
-0.02914111688733101,
0.2026597112417221,
-0.1076522022485733,
0.12767164409160614,
0.054530173540115356,
-0.03121010959148407,
0.20684915781021118,
0.09868733584880829,
-0.10102050751447678,
0.06296989321708679,
-0.07583421468734741,
-0.005184777081012726,
-0.10675172507762909,
0.1998133510351181,
0.08684014528989792,
-0.03238307684659958,
0.12576045095920563,
-0.01499423012137413,
0.06741002202033997,
0.2046383023262024,
-0.16334031522274017,
-0.23180438578128815,
0.18080592155456543,
-0.07653096318244934,
0.015255245380103588,
-0.03199576213955879,
-0.11888149380683899,
0.010464126244187355,
0.10576983541250229,
0.01905190944671631,
0.23456314206123352,
0.04919050261378288,
0.004424259997904301,
0.14200499653816223,
0.014339018613100052,
0.11227928847074509,
0.10710260272026062,
-0.07323025166988373,
0.01552865281701088,
0.05965297669172287,
0.14345897734165192,
-0.0503988116979599,
-0.2648538649082184,
-0.12528575956821442,
-0.12368804961442947,
0.11091011762619019,
-0.07273419946432114,
0.11940278112888336,
0.0347292423248291,
-0.03898894041776657,
0.00048343310481868684,
-0.36354130506515503,
0.08911143243312836,
-0.1900346726179123,
0.22109292447566986,
0.01888948865234852,
0.0328017994761467,
-0.03629755228757858,
0.041340555995702744,
-0.05467910319566727,
0.020952463150024414,
0.15207749605178833,
0.25010788440704346,
0.1704135686159134,
0.009271146729588509,
0.03491796553134918,
-0.029265549033880234,
0.09223207086324692,
0.001045965007506311,
0.2012559324502945,
0.07156041264533997,
-0.11717397719621658,
0.26575878262519836,
-0.10480043292045593,
0.14771424233913422,
0.12075743824243546,
-0.016329754143953323,
-0.017820827662944794,
0.2452896684408188,
0.18508099019527435,
-0.17224335670471191,
-0.05105625465512276,
0.04171071574091911,
-0.07898013293743134,
-0.06035621836781502,
0.1381615400314331,
-0.10572764277458191,
0.07271985709667206,
0.04217357560992241,
-0.03995837643742561,
-0.14951838552951813,
-0.26744136214256287,
0.11386062949895859,
0.10264109820127487,
-0.01928178407251835,
-0.10134381055831909,
-0.30120396614074707,
0.17520225048065186,
-0.029897024855017662,
-0.16927430033683777,
0.15896059572696686,
0.26449811458587646,
-0.02212977409362793,
-0.016268232837319374,
-0.1001671701669693,
0.027962353080511093,
-0.13479167222976685,
0.013376119546592236,
-0.18266931176185608,
0.25749412178993225,
-0.055740680545568466,
-0.1732701063156128,
-0.05022856593132019,
-0.0686463713645935,
0.0530736967921257,
-0.15407328307628632,
-0.15139202773571014,
-0.07921365648508072,
0.056450795382261276,
-0.02974732592701912,
-0.15586915612220764,
0.1638304889202118,
-0.07371146976947784,
-0.20347896218299866,
-0.027950137853622437,
0.018118467181921005,
0.18539786338806152,
0.1983785480260849,
-0.22777937352657318,
0.06294247508049011,
-0.009217485785484314,
0.07544002681970596,
-0.1781264841556549,
0.30369821190834045,
-0.046812474727630615,
0.00411507673561573,
-0.11948582530021667,
0.02293660119175911,
0.19763821363449097,
-0.022401949390769005,
0.074900321662426,
-0.041600022464990616,
-0.09847606718540192,
0.041397202759981155,
-0.07455605268478394,
-0.1097336858510971,
0.03887553885579109,
-0.0468616709113121,
-0.02125873602926731,
0.035052135586738586,
-0.14556249976158142,
-0.09263832122087479,
0.00911693088710308,
-0.03990880399942398,
-0.01971333473920822,
-0.08428631722927094,
0.24485906958580017,
-0.3297831118106842,
-0.009354024194180965,
0.1505875587463379,
-0.24290801584720612,
-0.15798677504062653,
-0.08582102507352829,
-0.08357422798871994,
0.05921420454978943,
0.2576257586479187,
-0.1625434160232544,
0.05711706727743149,
0.000057918230595532805,
0.3253888189792633,
0.12565508484840393,
0.04106098785996437,
-0.04743005707859993,
-0.02705548331141472,
0.010130391456186771,
-0.17090216279029846,
0.041815243661403656,
0.10476815700531006,
0.15559175610542297,
-0.06148241087794304,
0.12741336226463318,
-0.01755654439330101,
-0.11057986319065094,
-0.039394740015268326,
0.28261324763298035,
0.14852523803710938,
0.18395963311195374,
0.011671577580273151,
0.07425984740257263,
0.24256935715675354,
-0.2002977579832077,
0.05235803499817848,
0.19245032966136932,
0.1653851717710495,
-0.34379392862319946,
-0.10652785748243332,
-0.21616654098033905,
0.13856996595859528,
-0.09061684459447861,
-0.1330123096704483,
-0.12368343025445938,
0.019588882103562355,
-0.030020372942090034,
-0.02830079384148121,
-0.14335155487060547,
0.024409249424934387,
0.005916310474276543,
0.10587502270936966,
-0.1146531030535698,
0.394246369600296,
-0.1250670701265335,
-0.023516757413744926,
-0.07528536766767502,
0.10882917791604996,
-0.06916961073875427,
-0.04936427250504494,
0.12481264024972916,
0.14436021447181702,
-0.296590656042099,
-0.034836020320653915,
-0.11929617077112198,
0.07756964862346649,
-0.034807104617357254,
-0.02059328928589821,
0.06341931223869324,
-0.08564338088035583,
0.10795038193464279,
-0.05083443969488144,
0.2599622309207916,
-0.2222989946603775,
0.10283812880516052,
0.0011332491412758827,
-0.010351629927754402,
-0.0015993535052984953,
0.18009932339191437,
-0.08977935463190079,
-0.05284182354807854,
0.20245090126991272,
0.0614016018807888,
0.046268533915281296,
0.13340076804161072,
-0.06563584506511688,
-0.08266954869031906,
-0.06901416182518005,
-0.22894547879695892,
-0.15877573192119598,
-0.07695618271827698,
-0.012056260369718075,
0.05130225792527199,
0.025984713807702065,
-0.1447286456823349,
-0.13858461380004883,
-0.024791225790977478,
0.06745181232690811,
-0.10831128805875778,
-0.03716329485177994,
0.07551329582929611,
0.15194016695022583,
-0.013463609851896763,
-0.024977916851639748,
-0.16685454547405243,
-0.13134323060512543,
-0.0725923627614975,
-0.09055095911026001,
-0.16849443316459656,
0.1117803230881691,
-0.003988224547356367,
-0.21617750823497772,
-0.3014959692955017,
-0.13689465820789337,
-0.15358524024486542,
0.08295593410730362,
0.02512006089091301,
-0.04916827753186226,
-0.013981476426124573,
0.038186393678188324,
0.05406123399734497,
-0.1061745136976242,
0.1042734906077385,
0.05106476694345474,
0.053811583667993546
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. warranted in most instances. Although PS is exceedingly rare, a robust support group infrastructure exists and many families find this very helpful (see Resources).SurveillanceIndividualized surveillance plans for the skeletal, pulmonary, soft-tissue, and other manifestations of PS should be developed according to the individual's specific needs.Because of the predisposition to a range of tumors (most of which are benign) individuals with PS should be monitored by their primary care provider with regular evaluations including a directed medical history and examination; periodic imaging is not indicated.Agents/Circumstances to AvoidMedications that increase the risk of DVT or are procoagulant should be avoided. Medications that increase growth (e.g., androgenic steroids or growth hormone) should be avoided.Evaluation of Relatives at RiskBecause PS is not inherited, relatives are not at increased risk and do not require evaluation.Pregnancy ManagementThere are no data on the management of pregnancy in women with PS. Pregnancy presents theoretic risks, | [
-0.2221413105726242,
-0.07924060523509979,
-0.0823126882314682,
-0.2378329187631607,
0.10931666940450668,
0.038470976054668427,
-0.12795105576515198,
-0.10937325656414032,
-0.14621570706367493,
-0.15629760921001434,
0.14682777225971222,
-0.021583056077361107,
-0.09781527519226074,
-0.07156502455472946,
-0.15112608671188354,
0.26686063408851624,
-0.2110791653394699,
0.05779728665947914,
0.13791589438915253,
0.31769710779190063,
0.14280129969120026,
-0.0879843533039093,
-0.14872349798679352,
0.040815599262714386,
-0.04248790442943573,
-0.10430701076984406,
0.10194842517375946,
0.05505060404539108,
-0.006028375122696161,
0.03820238634943962,
-0.19581077992916107,
0.07175441831350327,
-0.18511901795864105,
-0.29182717204093933,
-0.14795640110969543,
-0.26368293166160583,
-0.21693973243236542,
0.14958657324314117,
0.0018038826528936625,
0.17223429679870605,
-0.09847533702850342,
0.058005914092063904,
-0.029242277145385742,
-0.10468585789203644,
0.014634422026574612,
-0.07682061195373535,
0.06596703082323074,
0.055302105844020844,
0.023171663284301758,
0.2929731607437134,
-0.05881214886903763,
-0.1125016137957573,
0.07187941670417786,
-0.11155197024345398,
0.03926268219947815,
-0.046074654906988144,
0.08956915885210037,
-0.022811219096183777,
-0.3036435544490814,
-0.06822380423545837,
0.13945206999778748,
-0.04082260653376579,
-0.027009200304746628,
-0.1721988171339035,
0.0016267424216493964,
-0.23133723437786102,
-0.07657874375581741,
0.03628385066986084,
0.08975450694561005,
-0.1492932289838791,
0.3861555755138397,
-0.11501776427030563,
-0.014041543938219547,
0.06534848362207413,
0.10341689735651016,
0.07387476414442062,
0.03873540833592415,
-0.24541914463043213,
-0.01957901194691658,
-0.1293855607509613,
0.02409193478524685,
-0.062153786420822144,
-0.08387217670679092,
0.00903038214892149,
-0.1631215363740921,
-0.08403196185827255,
-0.08601470291614532,
0.1632070094347,
-0.10322604328393936,
-0.04762398451566696,
-0.03973143920302391,
-0.03677494078874588,
0.13838718831539154,
0.049073487520217896,
0.25768545269966125,
-0.15127676725387573,
0.11025772243738174,
0.1679094433784485,
-0.0913945809006691,
0.04334466904401779,
0.1210983395576477,
0.22764798998832703,
-0.13290613889694214,
-0.0659039318561554,
0.12018037587404251,
-0.026405755430459976,
0.000984424026682973,
-0.039951663464307785,
-0.05759316682815552,
-0.058412499725818634,
0.01011795736849308,
0.06635671108961105,
0.10724606364965439,
-0.04158993810415268,
-0.145609050989151,
-0.2734262943267822,
0.17653581500053406,
0.11770450323820114,
-0.06096374988555908,
-0.15361985564231873,
-0.19313785433769226,
-0.08014482259750366,
-0.10329155623912811,
-0.25802844762802124,
0.1297229826450348,
-0.0049997237510979176,
0.20308327674865723,
-0.1861928552389145,
0.032325901091098785,
-0.10613849014043808,
0.23308385908603668,
-0.13822060823440552,
-0.06464683264493942,
-0.1886349320411682,
0.02023695409297943,
-0.05773160234093666,
0.11642056703567505,
-0.11930546909570694,
0.08332275599241257,
0.09252185374498367,
0.31585362553596497,
0.32017838954925537,
0.3530955910682678,
0.15633489191532135,
-0.09382019191980362,
-0.015601126477122307,
0.15561088919639587,
0.10075699537992477,
0.12308871001005173,
-0.04178266227245331,
0.2989618480205536,
-0.2590199112892151,
0.07649727165699005,
0.11058494448661804,
0.03216128796339035,
-0.148470938205719,
-0.06350693851709366,
0.16066230833530426,
-0.18559572100639343,
-0.03411426767706871,
0.06617545336484909,
-0.07383889704942703,
-0.02101403847336769,
-0.047702740877866745,
-0.012584784999489784,
0.05055906996130943,
0.09743878990411758,
0.06244127079844475,
0.0340462252497673,
-0.135419562458992,
-0.06930016726255417,
-0.0043245358392596245,
-0.01848064921796322,
0.028666576370596886,
-0.11525663733482361,
0.008294079452753067,
0.11016242951154709,
0.017465338110923767,
-0.06252393126487732,
0.11064086854457855,
-0.05889779329299927,
-0.21896661818027496,
-0.015156937763094902,
-0.2438451200723648,
-0.03774287924170494,
-0.17694124579429626,
-0.0227628443390131,
0.20052841305732727,
-0.08054392039775848,
0.15727579593658447,
0.120668426156044,
0.028123289346694946,
-0.1056690439581871,
0.0057710339315235615,
-0.09807470440864563,
-0.281139999628067,
-0.08749856054782867,
-0.14392270147800446,
-0.03186899796128273,
-0.03739776089787483,
0.05205261707305908,
-0.08255369961261749,
0.07795676589012146,
0.025497496128082275,
0.18560269474983215,
0.07249944657087326,
0.0847732350230217,
-0.32718193531036377,
0.07392195612192154,
-0.06829923391342163,
0.012783856131136417,
0.1525522917509079,
-0.032499998807907104,
0.04267619922757149,
0.16847896575927734,
-0.16499747335910797,
-0.1855667233467102,
-0.162875235080719,
-0.10356773436069489,
0.06823447346687317,
-0.3410080671310425,
0.024064036086201668,
-0.29799017310142517,
-0.08146456629037857,
-0.3263106644153595,
0.06302633136510849,
0.022720346227288246,
-0.007567735854536295,
0.14354608952999115,
0.01914994791150093,
-0.1291210949420929,
0.34057551622390747,
-0.01712501235306263,
0.1372034251689911,
0.02734210155904293,
-0.2866465747356415,
-0.13525688648223877,
0.3857458829879761,
0.16999737918376923,
0.18021930754184723,
0.03643006086349487,
0.056227367371320724,
0.12296662479639053,
0.07366735488176346,
-0.09291304647922516,
0.09470454603433609,
0.04568294808268547,
0.041011542081832886,
-0.18924133479595184,
-0.012433703057467937,
0.08230502158403397,
-0.23030909895896912,
0.16561689972877502,
0.07202889025211334,
-0.117669478058815,
-0.13577434420585632,
0.2989341616630554,
0.005301651079207659,
-0.04989885911345482,
-0.04211367666721344,
0.10334018617868423,
0.1638110727071762,
0.3113192617893219,
-0.1373259425163269,
-0.19516728818416595,
-0.046189259737730026,
-0.03741574287414551,
0.0977073535323143,
-0.23977555334568024,
-0.26346078515052795,
-0.11921726912260056,
0.11057871580123901,
0.04305081441998482,
-0.07438434660434723,
-0.09333505481481552,
0.006482034921646118,
0.0448320135474205,
0.06568438559770584,
0.082241490483284,
0.1733127236366272,
0.14836497604846954,
0.11483125388622284,
-0.13555321097373962,
-0.10198446363210678,
0.19564427435398102,
0.09620802104473114,
-0.1858237087726593,
0.2534325122833252,
0.0646013617515564,
-0.06791965663433075,
0.1842355579137802,
0.18349096179008484,
-0.0641242042183876,
-0.06807947903871536,
0.3226047456264496,
0.2034384310245514,
-0.05704206973314285,
-0.014814559370279312,
-0.003780011786147952,
-0.09665746986865997,
0.03393716737627983,
0.1252267211675644,
-0.2408541589975357,
0.061747122555971146,
-0.1939086616039276,
-0.09497662633657455,
-0.019440872594714165,
-0.007702962961047888,
0.08540987968444824,
0.016694150865077972,
-0.07308348268270493,
0.20324596762657166,
0.033005960285663605,
0.10643207281827927,
-0.04669380933046341,
-0.022739775478839874,
-0.25326207280158997,
-0.08418745547533035,
-0.05977139249444008,
-0.04377635568380356,
-0.03686971589922905,
-0.16309337317943573,
0.129341721534729,
0.06349959224462509,
0.027532164007425308,
0.05344878509640694,
0.006594306789338589,
0.2614130675792694,
-0.10346819460391998,
-0.017352651804685593,
-0.13782943785190582,
0.03645167127251625,
-0.1707579791545868,
-0.14207862317562103,
0.012653721496462822,
-0.021189182996749878,
0.1025390625,
-0.024277258664369583,
-0.05508074536919594,
-0.23746365308761597,
-0.040240779519081116,
-0.2879183292388916,
0.15230171382427216,
0.04452165588736534,
-0.0672588050365448,
0.16585610806941986,
0.059729449450969696,
0.09187298268079758,
-0.12412475049495697,
-0.09328480064868927,
-0.03287834674119949,
-0.2931303083896637,
0.0649273693561554,
-0.26389285922050476,
0.05138428881764412,
-0.010708088055253029,
0.10545236617326736,
0.08435986936092377,
-0.05389050021767616,
0.10997165739536285,
-0.06063639000058174,
0.07342604547739029,
0.009138021618127823,
-0.14174553751945496,
0.07160509377717972,
0.140772745013237,
-0.2678879499435425,
-0.031242558732628822,
0.32653459906578064,
-0.021389976143836975,
0.24476788938045502,
0.05903404578566551,
0.008096453733742237,
-0.2040107548236847,
0.050305310636758804,
0.17497579753398895,
-0.30540454387664795,
0.12766927480697632,
-0.07319118827581406,
-0.15538252890110016,
-0.20303033292293549,
0.10473233461380005,
0.050176095217466354,
-0.0727643370628357,
-0.15601441264152527,
0.14254216849803925,
-0.20360617339611053,
0.2101995050907135,
-0.2645231783390045,
-0.10632626712322235,
0.09762010723352432,
-0.03411277383565903,
-0.03092832677066326,
0.07538241893053055,
-0.12667196989059448,
-0.029106970876455307,
0.1501191109418869,
-0.28932681679725647,
-0.1310233622789383,
0.07467904686927795,
0.04550251364707947,
-0.03709224611520767,
0.19588667154312134,
0.20030230283737183,
0.09380057454109192,
-0.09720270335674286,
-0.027862610295414925,
-0.11182408034801483,
-0.006378635298460722,
0.36171025037765503,
-0.11879810690879822,
-0.03369686380028725,
0.06244354322552681,
-0.04726065322756767,
-0.004479020833969116,
-0.09872888028621674,
-0.14806506037712097,
-0.005494125187397003,
-0.027403974905610085,
-0.13598865270614624,
0.03427502140402794,
-0.1328459233045578,
0.060004882514476776,
-0.1607210785150528,
-0.2863834798336029,
0.011283311992883682,
-0.07255300879478455,
0.07537875324487686,
-0.01953250542283058,
0.18295998871326447,
0.3637944161891937,
-0.01962151564657688,
-0.26526355743408203,
0.10869747400283813,
-0.16342902183532715,
0.18948788940906525,
0.00190939090680331,
0.13968369364738464,
0.1563558131456375,
-0.17105570435523987,
0.3096727728843689,
-0.0726463794708252,
0.1843913346529007,
0.05404616519808769,
0.031182298436760902,
-0.05670234560966492,
-0.08277533948421478,
0.12062206119298935,
0.02637033350765705,
0.05401146784424782,
-0.09356524795293808,
-0.06471613049507141,
-0.011724565178155899,
-0.07697807252407074,
0.05461122840642929,
0.11514317989349365,
-0.11003107577562332,
0.14503836631774902,
-0.16607683897018433,
0.01969085820019245,
-0.17033246159553528,
0.028340499848127365,
0.08242969214916229,
-0.02734968438744545,
0.041002463549375534,
0.046824242919683456,
-0.2976115942001343,
0.12295401096343994,
-0.04020499438047409,
-0.0625104010105133,
-0.12028827518224716,
0.07596945017576218,
0.11730550974607468,
-0.02483341284096241,
-0.03976983577013016,
0.017450502142310143,
-0.1739446371793747,
0.2821895182132721,
-0.17069189250469208,
0.14145226776599884,
0.21388110518455505,
0.07062310725450516,
0.06226954981684685,
-0.03756821155548096,
0.006592355668544769,
0.08117493987083435,
0.19816306233406067,
-0.20415347814559937,
0.10170231759548187,
-0.22759968042373657,
0.13864512741565704,
-0.054921794682741165,
-0.02685358189046383,
0.28074708580970764,
-0.08028046041727066,
-0.19418875873088837,
0.13955529034137726,
0.04185239225625992,
-0.009985527023673058,
-0.13915258646011353,
0.037811923772096634,
0.06295009702444077,
0.07069776952266693,
0.05652213096618652,
0.09902393817901611,
-0.0698552057147026,
0.04952073469758034,
-0.14201579988002777,
-0.23353807628154755,
0.08968151360750198,
-0.11342445760965347,
-0.07985734194517136,
-0.024554599076509476,
-0.07252734154462814,
-0.14049707353115082,
0.12133030593395233,
0.07272908091545105,
0.04627348482608795,
0.15172675251960754,
-0.03843873366713524,
-0.036610037088394165,
-0.017456937581300735,
0.039729971438646317,
0.06045091897249222,
-0.06605543941259384,
-0.03019939363002777,
0.09150678664445877,
0.11176268011331558,
-0.20246870815753937,
-0.15242508053779602,
-0.12048663198947906,
-0.11565551161766052,
0.08973655849695206,
0.1359155774116516,
0.06545530259609222,
0.011811256408691406,
-0.07407920807600021,
-0.10773883759975433,
-0.39230483770370483,
0.16061432659626007,
-0.14997629821300507,
0.1409781128168106,
0.22697879374027252,
0.1725093424320221,
0.00047255592653527856,
0.08010317385196686,
0.060776323080062866,
-0.0937565490603447,
0.00006427765765693039,
0.19671809673309326,
0.009533362463116646,
0.14482639729976654,
0.10446055233478546,
-0.12160240113735199,
-0.040798429399728775,
-0.08730544149875641,
0.09174270182847977,
0.11470964550971985,
0.11033792048692703,
0.2845362722873688,
0.10425122082233429,
0.019324248656630516,
0.05862755328416824,
-0.2084774374961853,
-0.07490944862365723,
0.2202865183353424,
0.3063328266143799,
-0.0754028707742691,
-0.06206614151597023,
-0.003435470862314105,
0.03216148167848587,
-0.08592022955417633,
0.07814809679985046,
-0.10679272562265396,
0.05728406086564064,
-0.09168854355812073,
-0.08457479625940323,
-0.04322235658764839,
-0.14879289269447327,
0.10083023458719254,
0.09532822668552399,
-0.22785203158855438,
-0.08991573750972748,
-0.2445680797100067,
0.12933506071567535,
0.11099016666412354,
-0.24375109374523163,
0.32806292176246643,
0.2700502276420593,
0.0005738829495385289,
0.010001873597502708,
-0.07837294042110443,
-0.011920119635760784,
-0.19255758821964264,
0.05782477185130119,
-0.04075117036700249,
0.0018921593436971307,
-0.06590037047863007,
0.006892524193972349,
0.05595175921916962,
-0.03560265526175499,
0.11682663857936859,
-0.05238565802574158,
-0.28198152780532837,
-0.12011928856372833,
-0.023591704666614532,
0.1369573026895523,
-0.12704548239707947,
0.36527299880981445,
-0.11285565048456192,
-0.26891130208969116,
-0.034697528928518295,
0.21037450432777405,
0.02858848311007023,
0.16425471007823944,
-0.3456045389175415,
-0.03155126795172691,
-0.22524145245552063,
0.07259727269411087,
-0.08194731920957565,
0.4844905734062195,
0.11812382191419601,
0.08678063005208969,
0.0035427818074822426,
-0.07558716833591461,
0.26822400093078613,
-0.09799113124608994,
0.020527957007288933,
0.10121230781078339,
-0.09938709437847137,
0.021086765453219414,
-0.13209623098373413,
0.002045104978606105,
0.10514453053474426,
0.04311613738536835,
-0.1836586892604828,
-0.000017496156942797825,
-0.20595596730709076,
0.09708677977323532,
-0.11499975621700287,
-0.036135733127593994,
0.014690407551825047,
-0.05939950793981552,
0.13584241271018982,
-0.16724027693271637,
0.05703682079911232,
0.06855783611536026,
-0.1448926031589508,
-0.11495321244001389,
-0.2208855003118515,
-0.15607810020446777,
0.02190481498837471,
0.1463642418384552,
-0.114277184009552,
0.019795184955000877,
-0.10280288010835648,
0.2855320870876312,
0.092244453728199,
-0.10555661469697952,
-0.05941765382885933,
-0.054817527532577515,
-0.08620379865169525,
-0.18714815378189087,
-0.0015965275233611465,
0.14747634530067444,
0.07663754373788834,
-0.00004134126356802881,
0.10462077707052231,
-0.16298504173755646,
-0.10486927628517151,
-0.03404359892010689,
0.24217380583286285,
0.008945710025727749,
0.10561176389455795,
0.08515472710132599,
0.006160287652164698,
0.17128430306911469,
-0.22321009635925293,
0.006464351899921894,
0.23182198405265808,
0.04469212517142296,
-0.15114174783229828,
-0.19864995777606964,
-0.25097134709358215,
-0.026917485520243645,
-0.16192300617694855,
-0.03824496641755104,
-0.09003099799156189,
0.16642674803733826,
0.02610759437084198,
-0.0626678615808487,
-0.07478580623865128,
0.07522909343242645,
0.02707020752131939,
-0.07842203974723816,
-0.028161324560642242,
0.39492639899253845,
-0.059539880603551865,
0.13475802540779114,
-0.15050218999385834,
0.0849015936255455,
-0.013596118427813053,
-0.014032603241503239,
0.06375054270029068,
0.022850528359413147,
-0.14830978214740753,
0.06749814748764038,
-0.17608891427516937,
0.031899746507406235,
-0.2490043342113495,
-0.0805962011218071,
-0.012895562686026096,
-0.05535415932536125,
0.24048654735088348,
-0.05096007511019707,
0.31068095564842224,
-0.15724951028823853,
0.1510941982269287,
0.07864927500486374,
-0.02208551950752735,
-0.1523655503988266,
0.1452891230583191,
-0.051093246787786484,
-0.04245086386799812,
0.17209632694721222,
-0.016754576936364174,
-0.19314807653427124,
0.034632325172424316,
0.24079467356204987,
-0.04478902742266655,
-0.1536547988653183,
-0.18549682199954987,
-0.1826268434524536,
-0.05802437290549278,
0.20327122509479523,
0.0514802411198616,
0.005376240238547325,
-0.17133882641792297,
-0.03242701292037964,
-0.004344932734966278,
-0.004974715877324343,
-0.11055529117584229,
0.058280374854803085,
0.09640274196863174,
0.13498367369174957,
-0.08678912371397018,
0.11209812760353088,
-0.11123764514923096,
0.07122283428907394,
-0.10666713118553162,
-0.02324162982404232,
0.033066291362047195,
0.10143744200468063,
0.10502525418996811,
-0.18627715110778809,
-0.307748943567276,
-0.14518848061561584,
-0.06864378601312637,
0.14026090502738953,
-0.04521840438246727,
-0.07470783591270447,
-0.16223402321338654,
-0.10646399855613708,
0.11600092053413391,
-0.01198446936905384,
0.09942462295293808,
0.14403431117534637,
0.20432321727275848
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. medical history and examination; periodic imaging is not indicated.Agents/Circumstances to AvoidMedications that increase the risk of DVT or are procoagulant should be avoided. Medications that increase growth (e.g., androgenic steroids or growth hormone) should be avoided.Evaluation of Relatives at RiskBecause PS is not inherited, relatives are not at increased risk and do not require evaluation.Pregnancy ManagementThere are no data on the management of pregnancy in women with PS. Pregnancy presents theoretic risks, especially the risk of thrombosis of the pelvic veins.Therapies Under InvestigationSearch ClinicalTrials.gov in the US and www.ClinicalTrialsRegister.eu in Europe for access to information on clinical studies for a wide range of diseases and conditions. Note: There may not be clinical trials for this disorder. | [
-0.19668889045715332,
-0.07328705489635468,
-0.2016773521900177,
-0.3165663778781891,
0.13409404456615448,
-0.05442152917385101,
-0.03888509050011635,
-0.1337006688117981,
-0.1138216033577919,
-0.16249100863933563,
0.09849366545677185,
0.11101771146059036,
-0.02901967242360115,
-0.09652002155780792,
-0.15312334895133972,
0.3939257264137268,
-0.19295714795589447,
-0.016435710713267326,
0.13314604759216309,
0.3286409080028534,
0.13252167403697968,
-0.08752478659152985,
-0.11787305027246475,
-0.03495483472943306,
-0.022077269852161407,
-0.07827052474021912,
0.2625007629394531,
-0.037333033978939056,
-0.1005929708480835,
0.01490712258964777,
-0.14704541862010956,
0.053357407450675964,
-0.2840043902397156,
-0.2334877848625183,
-0.07802879065275192,
-0.2400866001844406,
-0.2365879863500595,
0.13274125754833221,
0.0060218097642064095,
0.10070370137691498,
-0.07595693320035934,
0.06462754309177399,
-0.12570491433143616,
-0.19093768298625946,
0.12646757066249847,
-0.19509923458099365,
0.08281152695417404,
0.1305363029241562,
0.070064976811409,
0.33478471636772156,
-0.07958933711051941,
-0.14979739487171173,
0.014146902598440647,
-0.1452188342809677,
0.12601181864738464,
0.024584978818893433,
0.16470207273960114,
-0.04317467659711838,
-0.319357693195343,
-0.08865604549646378,
0.1702420562505722,
-0.08337496221065521,
0.04171808063983917,
-0.31734704971313477,
-0.016146918758749962,
-0.1499946415424347,
-0.15834419429302216,
0.09751967340707779,
0.05671106278896332,
-0.052353713661432266,
0.3792397677898407,
-0.16203267872333527,
-0.0013495930470526218,
0.05509598180651665,
0.18612045049667358,
0.03490293398499489,
0.15095436573028564,
-0.12833383679389954,
-0.001041506533510983,
-0.09188401699066162,
-0.01721549965441227,
-0.12162241339683533,
-0.0884876400232315,
-0.040777407586574554,
-0.19343417882919312,
-0.11361083388328552,
-0.12139783799648285,
0.15623857080936432,
-0.06995812058448792,
0.03135165199637413,
0.008819636888802052,
0.09705798327922821,
0.14150317013263702,
0.08274511247873306,
0.22134141623973846,
-0.14693298935890198,
0.08955682069063187,
0.16606587171554565,
-0.00554615119472146,
0.06208966299891472,
0.17152364552021027,
0.2553223669528961,
-0.19375209510326385,
-0.07440033555030823,
0.08932250738143921,
-0.03345842659473419,
-0.056337252259254456,
-0.001768269925378263,
0.07749960571527481,
-0.03615707531571388,
0.04380621388554573,
-0.0016971734585240483,
0.12342949956655502,
0.021673426032066345,
-0.08106467127799988,
-0.18243221938610077,
0.21614015102386475,
0.03731195628643036,
0.053645044565200806,
-0.17141534388065338,
-0.2168642282485962,
-0.06350041180849075,
-0.020505864173173904,
-0.19210021197795868,
0.18016307055950165,
-0.06374366581439972,
0.3624582588672638,
-0.1628953218460083,
0.057805199176073074,
-0.17941272258758545,
0.17815172672271729,
-0.11031517386436462,
0.009924426674842834,
-0.1235649436712265,
-0.013858449645340443,
-0.04957547411322594,
0.031260933727025986,
-0.03499011695384979,
0.07922103255987167,
0.11614439636468887,
0.34395140409469604,
0.3163715600967407,
0.2532663643360138,
0.05387866869568825,
-0.006795018445700407,
0.1363542526960373,
0.15703290700912476,
0.11728991568088531,
0.17050808668136597,
-0.07232646644115448,
0.38928723335266113,
-0.1987016499042511,
0.11381606757640839,
0.030056269839406013,
0.06275142729282379,
-0.24627448618412018,
-0.1186550110578537,
0.12118066847324371,
-0.17633147537708282,
-0.039003703743219376,
0.01062344666570425,
0.0014699040912091732,
0.046775031834840775,
0.07444385439157486,
-0.050361353904008865,
0.02574869804084301,
0.07436272501945496,
0.12112004309892654,
0.016681142151355743,
-0.136073037981987,
-0.07502318918704987,
0.02061295695602894,
0.027140198275446892,
-0.006038840394467115,
-0.043267808854579926,
-0.08498683571815491,
0.10210432857275009,
0.06768006831407547,
-0.10080830007791519,
0.12736175954341888,
0.00036980723962187767,
-0.14395178854465485,
0.07274673879146576,
-0.33068516850471497,
-0.09639981389045715,
-0.1653909981250763,
0.04340539872646332,
0.2944546639919281,
-0.15108437836170197,
0.13264665007591248,
0.11967157572507858,
-0.039527542889118195,
-0.17852939665317535,
0.11833640187978745,
-0.04726419970393181,
-0.32017675042152405,
-0.13082769513130188,
-0.12478978931903839,
0.04088984802365303,
-0.19392624497413635,
0.018077148124575615,
-0.0006736408686265349,
0.10412995517253876,
-0.03787386417388916,
0.15749280154705048,
0.14387556910514832,
-0.003601617645472288,
-0.313165545463562,
0.032132409512996674,
-0.15056900680065155,
-0.02994987927377224,
0.2550829350948334,
-0.08487832546234131,
0.06397007405757904,
0.10601115971803665,
-0.08439918607473373,
-0.17267121374607086,
-0.202533558011055,
-0.10633938014507294,
0.04497448727488518,
-0.3265552818775177,
-0.0008245990611612797,
-0.336576908826828,
-0.0506494976580143,
-0.3252090513706207,
0.25021135807037354,
0.07029497623443604,
-0.08637155592441559,
0.11027844995260239,
-0.029827723279595375,
-0.09444471448659897,
0.4009615480899811,
0.04087762162089348,
0.026384834200143814,
0.020612433552742004,
-0.3473989963531494,
-0.18057486414909363,
0.3652138411998749,
0.07027050107717514,
0.05565861985087395,
0.020497942343354225,
-0.0033627140801399946,
0.1271771639585495,
0.030532106757164,
-0.046509020030498505,
0.12887847423553467,
-0.00783976074308157,
-0.051281604915857315,
-0.10377128422260284,
-0.0073437076061964035,
0.09746988862752914,
-0.26579925417900085,
0.11990749090909958,
0.13286373019218445,
-0.235731840133667,
-0.21350298821926117,
0.32726341485977173,
0.009797279722988605,
-0.015799762681126595,
-0.05468391254544258,
0.17579926550388336,
0.2338777631521225,
0.3497188091278076,
-0.017140505835413933,
-0.22057946026325226,
-0.055845458060503006,
-0.09120962768793106,
0.10317977517843246,
-0.1996239870786667,
-0.22727026045322418,
-0.1177075207233429,
0.06355524063110352,
0.10930828750133514,
0.04226906970143318,
-0.11624018102884293,
0.011460233479738235,
0.10502926260232925,
0.052247434854507446,
0.13480199873447418,
0.09871429204940796,
0.10954556614160538,
0.02421531081199646,
-0.11260109394788742,
-0.0499354787170887,
0.23558098077774048,
0.019985614344477654,
-0.2021399885416031,
0.34583356976509094,
0.06328604370355606,
-0.04081343859434128,
0.10538381338119507,
0.17830608785152435,
-0.05949179083108902,
-0.023385806009173393,
0.389627605676651,
0.2215704768896103,
-0.1857714056968689,
-0.12667794525623322,
0.14607639610767365,
-0.09540543705224991,
0.017840001732110977,
0.05915437266230583,
-0.241260826587677,
0.012424823828041553,
-0.13930097222328186,
-0.13851186633110046,
0.08483526110649109,
0.09993806481361389,
0.1329561173915863,
0.04769425839185715,
-0.03811301290988922,
0.13021878898143768,
0.03943208232522011,
0.053748272359371185,
-0.1599896252155304,
-0.10454288870096207,
-0.1986480951309204,
0.006654464174062014,
0.005404527764767408,
0.02411106415092945,
0.0958007201552391,
-0.12251872569322586,
0.19078241288661957,
-0.11015521734952927,
0.015308794565498829,
0.05180148780345917,
0.05361013114452362,
0.25369179248809814,
-0.19735872745513916,
0.02760758250951767,
-0.10143005847930908,
0.0910855382680893,
-0.1298675537109375,
-0.041125789284706116,
0.04979609698057175,
-0.055971480906009674,
-0.007773992605507374,
0.027409115806221962,
-0.025071656331419945,
-0.061620838940143585,
-0.07794372737407684,
-0.29060444235801697,
0.19994182884693146,
-0.11666685342788696,
-0.006341210100799799,
0.19379715621471405,
0.012958009727299213,
0.17454521358013153,
-0.12259422987699509,
0.019372710958123207,
-0.06409352272748947,
-0.23535427451133728,
0.053452618420124054,
-0.19020742177963257,
0.04928625375032425,
-0.007137225940823555,
0.06682165712118149,
-0.004582086578011513,
-0.07425890117883682,
0.0931287333369255,
-0.08730241656303406,
0.009465179406106472,
-0.018050462007522583,
-0.04792667180299759,
-0.06405579298734665,
0.1568249613046646,
-0.2367689609527588,
-0.03929116949439049,
0.31093382835388184,
-0.0935683324933052,
0.2564604580402374,
-0.06259635090827942,
0.00047310281661339104,
-0.11354701966047287,
0.19532425701618195,
0.11136000603437424,
-0.24739345908164978,
0.161410853266716,
-0.03309345617890358,
-0.22841952741146088,
-0.23901315033435822,
0.11234796047210693,
0.11181646585464478,
-0.024969998747110367,
-0.02384144440293312,
0.005186364054679871,
-0.237092062830925,
0.16724781692028046,
-0.2368478775024414,
-0.11827370524406433,
-0.02390044927597046,
0.046163685619831085,
-0.09281329810619354,
0.026577988639473915,
-0.23883618414402008,
-0.09790216386318207,
0.15963344275951385,
-0.33610254526138306,
-0.21441665291786194,
0.024290289729833603,
0.04263223335146904,
-0.01831657625734806,
0.24149014055728912,
0.16453035175800323,
0.16429506242275238,
-0.038861144334077835,
-0.034597352147102356,
-0.09777400642633438,
-0.09435315430164337,
0.37511110305786133,
-0.10703758150339127,
-0.014432723633944988,
-0.022129949182271957,
-0.041486259549856186,
-0.009567364118993282,
-0.14795927703380585,
0.003148225601762533,
0.04862108826637268,
-0.05967220664024353,
-0.14172565937042236,
0.057038839906454086,
-0.09297290444374084,
-0.014051851816475391,
-0.21098636090755463,
-0.2592419385910034,
0.07574218511581421,
0.031240804120898247,
0.006433214992284775,
-0.02381962537765503,
0.22855925559997559,
0.39334389567375183,
-0.02278806082904339,
-0.23195873200893402,
0.014033353887498379,
-0.17396999895572662,
0.2150704711675644,
-0.13382680714130402,
0.17203576862812042,
0.08612179756164551,
-0.06750880181789398,
0.2670324444770813,
-0.046938471496105194,
0.30060309171676636,
0.03378741443157196,
-0.06548640131950378,
-0.07491089403629303,
-0.1333582103252411,
0.18849243223667145,
0.04995293915271759,
0.1606261283159256,
-0.11150024086236954,
-0.08739664405584335,
-0.08605202287435532,
-0.07823842018842697,
0.06163615733385086,
0.1425231248140335,
-0.1094624325633049,
0.12613461911678314,
-0.1576104313135147,
0.09408929944038391,
-0.16182509064674377,
-0.011712735518813133,
0.16684752702713013,
-0.0333138071000576,
0.03054089844226837,
0.02044549398124218,
-0.29634547233581543,
0.057166509330272675,
-0.006418557371944189,
-0.017515219748020172,
-0.11188910156488419,
0.0836576446890831,
0.033959053456783295,
-0.0748271718621254,
0.08703277260065079,
0.07788271456956863,
-0.20355258882045746,
0.292508989572525,
-0.12404739111661911,
0.07745440304279327,
0.26508164405822754,
0.10877828299999237,
0.05252916365861893,
-0.046506110578775406,
-0.06490959227085114,
0.09620814025402069,
0.222541943192482,
-0.11416389793157578,
0.02443513087928295,
-0.19584351778030396,
0.1256798356771469,
-0.022438030689954758,
-0.03773747757077217,
0.3624730110168457,
-0.14226846396923065,
-0.18699082732200623,
0.054524920880794525,
0.03844330087304115,
0.024873681366443634,
-0.09989181160926819,
-0.04780024290084839,
0.0999009758234024,
0.040459878742694855,
0.1413232833147049,
0.08288279920816422,
-0.1486869901418686,
-0.08104190230369568,
-0.11217010021209717,
-0.18961948156356812,
0.10771092027425766,
-0.012250191532075405,
-0.038935668766498566,
-0.07120136171579361,
0.02199440449476242,
-0.12883900105953217,
0.19244243204593658,
-0.010121569037437439,
-0.05783107504248619,
0.18538887798786163,
-0.05620403215289116,
0.03788236901164055,
0.052691373974084854,
-0.009774018079042435,
0.09109609574079514,
-0.09917183220386505,
-0.07763862609863281,
0.09993578493595123,
0.11603263765573502,
-0.2998773455619812,
-0.0027298384811729193,
-0.1129310354590416,
-0.08723075687885284,
0.07340077310800552,
0.11937328428030014,
0.06058897078037262,
-0.02408612333238125,
-0.10283812880516052,
-0.16779565811157227,
-0.3870203197002411,
0.11832624673843384,
-0.13468745350837708,
0.06114568933844566,
0.2016443908214569,
0.15315790474414825,
-0.06551843881607056,
0.09680523723363876,
0.1084858849644661,
-0.11121275275945663,
0.001563558354973793,
0.21837356686592102,
-0.012359420768916607,
0.1369640827178955,
0.16017766296863556,
-0.1321956366300583,
-0.07449930906295776,
-0.11740542948246002,
0.12734375894069672,
0.06102962791919708,
0.2036529779434204,
0.20446398854255676,
0.07316097617149353,
-0.051269128918647766,
0.04835663363337517,
-0.222270205616951,
-0.12253724783658981,
0.15622249245643616,
0.366584837436676,
-0.067247673869133,
-0.04822926223278046,
0.0384686216711998,
0.061273474246263504,
-0.10662902146577835,
0.10578984767198563,
-0.06873022764921188,
0.03156011924147606,
-0.10103827714920044,
-0.03627898544073105,
-0.01536352839320898,
-0.3299832344055176,
0.06518243998289108,
0.13751347362995148,
-0.1982317417860031,
0.024763992056250572,
-0.18413759768009186,
0.1155979260802269,
0.19033755362033844,
-0.2568329870700836,
0.31566691398620605,
0.2782377302646637,
-0.0684015154838562,
-0.014662623405456543,
-0.09792618453502655,
0.0704054906964302,
-0.1927826851606369,
-0.0017501397524029016,
-0.0372336320579052,
-0.04074639081954956,
-0.1667819321155548,
0.039992835372686386,
0.06697603315114975,
-0.031849123537540436,
-0.02703196555376053,
-0.03584391623735428,
-0.2617969512939453,
-0.17321370542049408,
-0.06797327846288681,
0.10578372329473495,
-0.15738332271575928,
0.3585762679576874,
-0.09743862599134445,
-0.1929367333650589,
0.007894741371273994,
0.2404438555240631,
0.002979349810630083,
0.16479046642780304,
-0.23498909175395966,
-0.03273262083530426,
-0.2441757321357727,
0.11826762557029724,
-0.028740594163537025,
0.6319288015365601,
0.14042174816131592,
0.11910121142864227,
-0.09499076008796692,
-0.07617954909801483,
0.2508977949619293,
-0.13542582094669342,
-0.05071331560611725,
0.0425175316631794,
-0.061336126178503036,
-0.04476294666528702,
-0.2614285349845886,
0.024824153631925583,
0.1624096930027008,
-0.04629212245345116,
-0.1625501811504364,
-0.05109696835279465,
-0.13745301961898804,
0.1148703545331955,
-0.14264966547489166,
-0.13461650907993317,
0.03745817020535469,
-0.09623390436172485,
0.06287229061126709,
-0.18023812770843506,
0.07985906302928925,
-0.027898414060473442,
0.016250457614660263,
-0.11682063341140747,
-0.3335827887058258,
-0.08292646706104279,
0.07787732034921646,
0.11672145128250122,
-0.053132958710193634,
-0.018191758543252945,
-0.06783594936132431,
0.28582829236984253,
0.01644272916018963,
-0.09556995332241058,
-0.007742736488580704,
-0.06049477681517601,
-0.055912017822265625,
-0.23701025545597076,
0.11454924941062927,
0.09738568961620331,
0.06320949643850327,
-0.02958061546087265,
0.142327219247818,
-0.25497063994407654,
-0.04360945150256157,
-0.14169897139072418,
0.29422974586486816,
0.008749166503548622,
0.05656328424811363,
0.1251593381166458,
-0.013044157065451145,
0.05929424986243248,
-0.07112070173025131,
0.013950794003903866,
0.20221415162086487,
-0.02338634617626667,
-0.15181121230125427,
-0.24303586781024933,
-0.15862692892551422,
-0.08461123704910278,
-0.22148090600967407,
-0.05850379541516304,
-0.19819560647010803,
0.23593276739120483,
0.06512530893087387,
0.0012252271408215165,
0.00760310236364603,
0.09656444191932678,
0.11136072129011154,
-0.24236668646335602,
-0.12795327603816986,
0.35153698921203613,
-0.17211467027664185,
0.03683331981301308,
-0.14197857677936554,
0.011314043775200844,
0.014041687361896038,
-0.056638702750205994,
0.14822319149971008,
0.023087209090590477,
-0.09559670090675354,
0.0002365133841522038,
-0.27753782272338867,
0.103216752409935,
-0.25660398602485657,
-0.003821165068075061,
-0.0055442382581532,
-0.08613093197345734,
0.10967322438955307,
0.040401630103588104,
0.39335983991622925,
-0.12342726439237595,
0.18399673700332642,
0.06034579500555992,
-0.09526807814836502,
-0.22190801799297333,
0.0765109583735466,
-0.028291067108511925,
-0.09611652046442032,
0.08220324665307999,
-0.049830641597509384,
-0.08567743748426437,
0.05905453860759735,
0.30410027503967285,
0.02988789603114128,
-0.15422697365283966,
-0.19075508415699005,
-0.18344587087631226,
0.024728812277317047,
0.11268971860408783,
0.1035434901714325,
0.14810088276863098,
-0.24045997858047485,
0.03868815675377846,
-0.03656315803527832,
-0.017292510718107224,
-0.060771118849515915,
0.16106051206588745,
0.11086545884609222,
0.18301594257354736,
-0.03922554850578308,
0.13803914189338684,
-0.13514167070388794,
0.1395537108182907,
-0.16714178025722504,
-0.036612194031476974,
0.19181890785694122,
0.15538324415683746,
0.12367311865091324,
-0.1914537250995636,
-0.4021644592285156,
-0.25267282128334045,
-0.14401058852672577,
0.09704948216676712,
-0.05019135773181915,
-0.16198396682739258,
-0.1832696497440338,
-0.09219562262296677,
0.18355628848075867,
-0.07559295743703842,
0.05144372209906578,
0.1810457557439804,
0.1851709485054016
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. presents theoretic risks, especially the risk of thrombosis of the pelvic veins.Therapies Under InvestigationSearch ClinicalTrials.gov in the US and www.ClinicalTrialsRegister.eu in Europe for access to information on clinical studies for a wide range of diseases and conditions. Note: There may not be clinical trials for this disorder. | [
-0.2623704671859741,
-0.09174085408449173,
-0.10381206125020981,
-0.25142616033554077,
0.06063130125403404,
0.09915489703416824,
0.028570765629410744,
-0.1616535633802414,
-0.11324046552181244,
0.08907687664031982,
0.25505179166793823,
0.18862181901931763,
-0.059237729758024216,
0.02155020460486412,
-0.01835276000201702,
0.35137230157852173,
-0.04534347355365753,
0.07421513646841049,
0.002126917475834489,
0.11195209622383118,
0.021370623260736465,
0.05782236531376839,
0.04044654220342636,
-0.030692083761096,
-0.017854321748018265,
0.06466758996248245,
0.31168049573898315,
0.03784266486763954,
-0.19781462848186493,
0.012005667202174664,
-0.15955188870429993,
0.003635555040091276,
-0.108333058655262,
-0.3315281867980957,
-0.10305395722389221,
-0.28578367829322815,
-0.1534741371870041,
0.08199875056743622,
0.1424599438905716,
-0.08170322328805923,
-0.12691333889961243,
0.10596045106649399,
0.054600875824689865,
0.028467601165175438,
0.09598007798194885,
-0.014840186573565006,
0.08907512575387955,
0.12661287188529968,
-0.026710888370871544,
0.24948149919509888,
0.1320173442363739,
-0.07382334023714066,
-0.008325885981321335,
-0.06584379076957703,
0.037095170468091965,
0.06525150686502457,
0.06106193736195564,
-0.10596852749586105,
-0.2617764472961426,
-0.11856731027364731,
0.18719565868377686,
-0.0559445358812809,
0.08020834624767303,
-0.3116157352924347,
-0.007212186232209206,
0.0308629609644413,
0.13933706283569336,
0.08946479111909866,
0.16682127118110657,
-0.10583149641752243,
0.302669882774353,
-0.08344001322984695,
0.04080711677670479,
0.10343470424413681,
0.11582791805267334,
-0.018110528588294983,
0.059780608862638474,
-0.1853143721818924,
-0.01015245821326971,
-0.16594696044921875,
-0.1426311433315277,
-0.09181215614080429,
0.04126623272895813,
-0.07480991631746292,
-0.10582573711872101,
-0.08022512495517731,
-0.12789104878902435,
0.021293511614203453,
-0.03390868008136749,
0.03976746276021004,
0.0023287972435355186,
0.10365933179855347,
0.16404595971107483,
0.1324649602174759,
0.18506307899951935,
-0.15897688269615173,
0.09984812140464783,
-0.06309619545936584,
-0.08768326044082642,
-0.02429853193461895,
0.027085743844509125,
0.17849162220954895,
-0.19861377775669098,
0.04380229488015175,
0.10866298526525497,
-0.14175766706466675,
-0.12102736532688141,
-0.11093080043792725,
0.19470298290252686,
-0.03209475055336952,
0.02470565401017666,
-0.005885741673409939,
0.08992855995893478,
-0.04471262916922569,
-0.13138647377490997,
-0.12470202147960663,
0.2703961431980133,
0.011885255575180054,
0.007969334721565247,
0.003553349059075117,
-0.175924152135849,
-0.04023582860827446,
-0.07514161616563797,
-0.1666399985551834,
0.16808418929576874,
0.18590113520622253,
0.3775980472564697,
-0.1796240508556366,
0.030762437731027603,
-0.16734662652015686,
0.08179409056901932,
-0.15868300199508667,
0.09731779992580414,
-0.1786668747663498,
-0.11586709320545197,
0.15373016893863678,
0.07487581670284271,
-0.03793416544795036,
0.3272014260292053,
-0.010433869436383247,
0.19094955921173096,
0.17660006880760193,
0.37109649181365967,
-0.131088525056839,
-0.0010670025367289782,
0.30184468626976013,
0.20620852708816528,
0.0222267284989357,
0.15133489668369293,
0.030763065442442894,
0.32678502798080444,
-0.10196632146835327,
0.11458421498537064,
0.07381725311279297,
-0.014168918132781982,
-0.3006136417388916,
-0.06842143088579178,
0.030153902247548103,
-0.21701902151107788,
-0.13112029433250427,
0.12203994393348694,
-0.15200164914131165,
-0.045811720192432404,
0.046216003596782684,
-0.014412079006433487,
0.026676597073674202,
0.1561250537633896,
0.08519218862056732,
0.10181176662445068,
0.0895031988620758,
-0.11971115320920944,
0.13747118413448334,
0.09232036769390106,
0.023150378838181496,
0.018453268334269524,
0.040434446185827255,
0.08959316462278366,
0.11426430195569992,
-0.08350137621164322,
0.17035794258117676,
0.1362895667552948,
-0.04355393350124359,
-0.028983687981963158,
-0.1474332958459854,
-0.204242542386055,
-0.07698357105255127,
0.17553097009658813,
0.16325421631336212,
-0.19061601161956787,
0.030976489186286926,
0.24068765342235565,
-0.18051350116729736,
-0.17739316821098328,
-0.05019688978791237,
0.030398694798350334,
-0.08755932748317719,
-0.2343015819787979,
0.04604186862707138,
-0.05663488060235977,
-0.21832667291164398,
0.045355986803770065,
0.05675743892788887,
0.102077916264534,
-0.12007129192352295,
0.2804383635520935,
0.10726863890886307,
-0.06828981637954712,
-0.182954803109169,
0.030155915766954422,
-0.1705232858657837,
0.07693330943584442,
0.3747790455818176,
-0.1388847976922989,
-0.022011931985616684,
-0.1095418706536293,
0.00025049972464330494,
-0.21967577934265137,
-0.24104507267475128,
-0.08323720842599869,
0.24023103713989258,
-0.309400737285614,
0.104939304292202,
-0.18823367357254028,
-0.09678280353546143,
-0.22679392993450165,
-0.002700213575735688,
0.030301596969366074,
-0.05820154398679733,
0.034611474722623825,
0.035875022411346436,
0.021616995334625244,
0.26520973443984985,
0.09125757217407227,
-0.04851115122437477,
0.061804551631212234,
-0.4006326496601105,
-0.13017970323562622,
0.24931541085243225,
0.1124255582690239,
0.2095339298248291,
-0.004849443212151527,
0.13830113410949707,
0.32060855627059937,
-0.012038120068609715,
0.03855770081281662,
0.07819211483001709,
-0.0612989217042923,
0.11665569990873337,
-0.20627951622009277,
0.10862500220537186,
0.06284775584936142,
-0.07492407411336899,
-0.037474848330020905,
-0.22367319464683533,
-0.2066078633069992,
-0.10215416550636292,
0.253623902797699,
-0.05576277896761894,
0.1327785700559616,
-0.0011910733301192522,
0.247721329331398,
0.0018598400056362152,
0.15852296352386475,
-0.11310234665870667,
-0.2048073709011078,
-0.05808847397565842,
-0.12455395609140396,
0.2571713328361511,
-0.06170925498008728,
-0.2574656307697296,
-0.16277441382408142,
0.10192210227251053,
0.12452623248100281,
-0.011307372711598873,
0.09189632534980774,
0.15724191069602966,
0.031819574534893036,
0.187406525015831,
0.046247195452451706,
0.13366584479808807,
0.009858793579041958,
-0.03091149404644966,
-0.07969972491264343,
-0.007532444782555103,
0.2446398288011551,
0.031108377501368523,
-0.17483077943325043,
0.1007281094789505,
-0.11245676875114441,
0.04699261114001274,
0.07683158665895462,
0.24568095803260803,
-0.08461002260446548,
-0.025080395862460136,
0.28223782777786255,
0.28910040855407715,
-0.12738080322742462,
0.011981054209172726,
-0.03816394880414009,
-0.30313101410865784,
0.08872821182012558,
0.07111399620771408,
-0.2723979651927948,
-0.026892662048339844,
-0.08857982605695724,
-0.19709987938404083,
0.1687397062778473,
-0.047056645154953,
0.12141111493110657,
-0.059614863246679306,
-0.038092177361249924,
0.2541065216064453,
0.020140424370765686,
-0.04535851627588272,
-0.07035493850708008,
0.002908227499574423,
-0.14233292639255524,
-0.019718173891305923,
0.08938081562519073,
-0.011772165074944496,
0.025687864050269127,
-0.3121464252471924,
0.15668435394763947,
-0.06821577996015549,
-0.021817810833454132,
-0.08967552334070206,
-0.02978997491300106,
0.12489650398492813,
-0.042685966938734055,
-0.04263148084282875,
-0.03165725618600845,
0.10140387713909149,
-0.08056961745023727,
0.027306975796818733,
0.23659281432628632,
-0.1364186704158783,
-0.10378624498844147,
-0.05600680038332939,
0.041955068707466125,
-0.18065929412841797,
-0.11042889207601547,
-0.23815429210662842,
0.08854561299085617,
-0.04965803772211075,
-0.08596666157245636,
0.24917036294937134,
0.015546286478638649,
0.03410468250513077,
-0.04625781998038292,
-0.1496620625257492,
0.004122525919228792,
-0.4097411334514618,
0.061288367956876755,
-0.2098218947649002,
0.15186013281345367,
-0.01840721257030964,
0.15531009435653687,
0.1025526225566864,
-0.1923104226589203,
0.04470105841755867,
-0.20973913371562958,
0.08827058225870132,
0.05115200951695442,
-0.1054542064666748,
-0.0509536936879158,
-0.041167911142110825,
-0.01761634834110737,
-0.00901760533452034,
0.19068293273448944,
-0.042242564260959625,
0.33386799693107605,
0.10605308413505554,
0.03964420408010483,
0.020618461072444916,
0.16029614210128784,
-0.03852587193250656,
-0.14826072752475739,
0.08588775247335434,
-0.168796569108963,
-0.23141559958457947,
-0.0902276262640953,
-0.08479317277669907,
0.09010207653045654,
-0.10704247653484344,
0.030432235449552536,
0.23165373504161835,
-0.26387566328048706,
0.09068064391613007,
-0.22856131196022034,
-0.08723880350589752,
0.16075579822063446,
-0.013438351452350616,
-0.12933802604675293,
0.05193077400326729,
-0.1999003142118454,
0.11700157821178436,
0.11079677194356918,
-0.2908806800842285,
0.01865839585661888,
-0.05676320195198059,
0.08741176128387451,
-0.26742374897003174,
0.15157657861709595,
-0.10116083920001984,
0.21046601235866547,
0.04085042327642441,
0.05570419132709503,
0.08302492648363113,
-0.18894211947917938,
0.29035770893096924,
-0.08289981633424759,
-0.13543418049812317,
0.029209785163402557,
-0.0070181358605623245,
0.06889669597148895,
-0.15917867422103882,
-0.03342263028025627,
-0.019676517695188522,
-0.19823938608169556,
-0.21577230095863342,
0.05997099354863167,
0.022120056673884392,
0.07109809666872025,
-0.12923584878444672,
-0.22773879766464233,
0.17758208513259888,
0.01913786679506302,
-0.0603361502289772,
-0.08097782731056213,
0.22362452745437622,
0.41361725330352783,
0.004632676485925913,
-0.10198565572500229,
0.03518699109554291,
-0.06789661943912506,
0.10432518273591995,
-0.10563919693231583,
0.2277161180973053,
-0.03340967744588852,
-0.044952649623155594,
0.2585972845554352,
-0.04086589068174362,
0.0839344710111618,
0.007490765303373337,
-0.09257777035236359,
-0.06959813088178635,
-0.09835991263389587,
0.1855020374059677,
-0.027053968980908394,
0.23026113212108612,
-0.10609620064496994,
0.11717621982097626,
0.07169142365455627,
-0.056841783225536346,
0.10388128459453583,
0.06836192309856415,
-0.13206295669078827,
0.050027672201395035,
-0.11344708502292633,
0.07076498866081238,
-0.17595651745796204,
0.13253898918628693,
0.05151202529668808,
-0.006431896239519119,
-0.10463587939739227,
0.08241592347621918,
-0.38411423563957214,
0.14098244905471802,
0.025804199278354645,
0.08534590154886246,
-0.1283215433359146,
-0.06212121993303299,
0.03815313056111336,
-0.0956716537475586,
0.11136610060930252,
0.0299763772636652,
-0.225385382771492,
0.20877772569656372,
-0.28044822812080383,
0.03715934231877327,
0.32452699542045593,
-0.07397085428237915,
-0.0005413427134044468,
-0.09632010012865067,
-0.07718738168478012,
0.11491740494966507,
0.004871746525168419,
-0.1899208277463913,
0.15537025034427643,
-0.1280813068151474,
0.0009646536782383919,
0.025746474042534828,
-0.08588212728500366,
0.3521072268486023,
0.008016245439648628,
-0.15210719406604767,
-0.005419742316007614,
-0.23913732171058655,
-0.07084640115499496,
-0.02657058835029602,
0.11175677180290222,
0.18315230309963226,
0.10038841515779495,
0.17486672103405,
0.04480439051985741,
0.014718319289386272,
-0.041755497455596924,
-0.11578666418790817,
-0.26338377594947815,
0.09793873876333237,
-0.12264204025268555,
0.07208216935396194,
0.05743802338838577,
0.08976525068283081,
0.07710423320531845,
0.12532594799995422,
0.018117642030119896,
-0.02356848493218422,
0.048981305211782455,
-0.13481158018112183,
-0.17196297645568848,
0.05920494720339775,
0.06121830269694328,
-0.08242737501859665,
0.013317068107426167,
-0.19331975281238556,
0.08444532752037048,
0.0882280245423317,
-0.24754242599010468,
-0.12328315526247025,
-0.11070042848587036,
-0.053538862615823746,
0.09726673364639282,
-0.04408980906009674,
0.09871696680784225,
-0.09635600447654724,
0.014415165409445763,
-0.10073015093803406,
-0.32299375534057617,
0.06000816449522972,
-0.1704893857240677,
0.040909815579652786,
0.07020816206932068,
0.09492801874876022,
-0.048570550978183746,
0.22830402851104736,
0.06604067236185074,
-0.01985018141567707,
0.21993176639080048,
0.2582472860813141,
-0.04213327169418335,
0.07678478956222534,
0.18239478766918182,
-0.0135633060708642,
-0.06435452401638031,
-0.07728690654039383,
0.2365291267633438,
0.19519399106502533,
-0.08451833575963974,
0.1677308976650238,
-0.09414537250995636,
-0.003332473337650299,
0.011369840241968632,
-0.050085775554180145,
0.09067915380001068,
0.10818576067686081,
0.3342965543270111,
-0.08962351083755493,
0.09351111948490143,
0.03187061846256256,
0.009120590053498745,
0.02540827915072441,
0.07033318281173706,
-0.1156185045838356,
-0.10323425382375717,
-0.06335347890853882,
-0.11820322275161743,
-0.07206380367279053,
-0.15657800436019897,
0.24376296997070312,
0.0890837162733078,
-0.20648004114627838,
-0.11221566796302795,
-0.2029733657836914,
-0.059411514550447464,
0.27262333035469055,
-0.204789936542511,
0.2590138912200928,
0.15962931513786316,
-0.08161560446023941,
-0.27097979187965393,
-0.2545526325702667,
0.05324387550354004,
-0.13876400887966156,
0.06620107591152191,
-0.09913484752178192,
-0.01970805414021015,
-0.10944253951311111,
0.009979412890970707,
0.037054382264614105,
-0.2009507268667221,
0.10492730140686035,
-0.17755402624607086,
-0.25552135705947876,
-0.09202337265014648,
0.04853438213467598,
0.14621305465698242,
-0.3154756426811218,
0.2192697674036026,
-0.137063130736351,
-0.015977775678038597,
-0.07111077755689621,
0.136114239692688,
0.03383530676364899,
0.3032350242137909,
-0.2757114768028259,
0.041116006672382355,
-0.07343490421772003,
0.1734580546617508,
-0.06404322385787964,
0.37045228481292725,
0.17917051911354065,
0.03760061040520668,
-0.11716680228710175,
-0.10786400735378265,
0.21736270189285278,
-0.2606789767742157,
-0.006719789933413267,
0.09436710178852081,
0.09879906475543976,
0.10733997821807861,
-0.005236877594143152,
-0.11640762537717819,
0.16950571537017822,
-0.15337109565734863,
0.026602186262607574,
-0.03449326753616333,
-0.16275328397750854,
0.07016785442829132,
-0.1043301597237587,
-0.1143462285399437,
-0.01736944355070591,
-0.18005724251270294,
0.10998068749904633,
-0.3104519546031952,
0.0032314711716026068,
0.1729135513305664,
-0.05313822254538536,
-0.13464653491973877,
-0.18548093736171722,
-0.09536246210336685,
0.21754391491413116,
0.22585326433181763,
0.07718345522880554,
0.03236871585249901,
0.03371349722146988,
0.3515074551105499,
0.02323135919868946,
-0.006494410336017609,
0.02381264604628086,
-0.10517341643571854,
-0.06062185391783714,
-0.11266162991523743,
-0.05742362514138222,
0.010570683516561985,
0.17248843610286713,
-0.1380198746919632,
0.14213979244232178,
-0.3907278776168823,
-0.00880421418696642,
-0.2985776662826538,
0.06274791806936264,
0.06783866882324219,
0.016315465793013573,
0.0029202415607869625,
0.06076357513666153,
-0.024740874767303467,
-0.05998527631163597,
0.05200003832578659,
0.201575368642807,
-0.07221440225839615,
-0.16779938340187073,
-0.17692317068576813,
-0.16457384824752808,
-0.1304030567407608,
-0.11349567770957947,
-0.0910332128405571,
0.07795144617557526,
0.24090656638145447,
-0.12010961025953293,
-0.022575290873646736,
-0.017481910064816475,
0.083220936357975,
0.10777929425239563,
-0.27460864186286926,
-0.18486826121807098,
0.2944680154323578,
-0.04110587015748024,
0.10890638828277588,
-0.1804521232843399,
0.09806312620639801,
-0.11122037470340729,
-0.001897776615805924,
0.08339367061853409,
0.019298775121569633,
-0.16898983716964722,
0.05939079821109772,
-0.16985122859477997,
0.24419109523296356,
0.05790049210190773,
-0.15765003859996796,
-0.192496657371521,
-0.027736306190490723,
0.03261161223053932,
-0.05787581205368042,
0.29045405983924866,
0.04034137725830078,
0.23953385651111603,
-0.0764516144990921,
-0.0008184845792129636,
-0.1480671763420105,
0.02254880964756012,
0.06971418112516403,
-0.07873964309692383,
0.07118774205446243,
-0.09237051755189896,
-0.20074303448200226,
-0.06531629711389542,
0.29227644205093384,
0.1623125821352005,
-0.1288270801305771,
-0.27302807569503784,
-0.2087731957435608,
0.15125708281993866,
0.07947932928800583,
0.07262291014194489,
0.15712113678455353,
-0.14087745547294617,
-0.0108709167689085,
-0.11585836857557297,
-0.10220498591661453,
-0.12927819788455963,
0.05330093204975128,
0.0530099980533123,
0.2975645065307617,
0.008824548684060574,
0.022227561101317406,
-0.2200528085231781,
-0.10992692410945892,
-0.2040432095527649,
0.03106624260544777,
0.041103560477495193,
-0.09797754883766174,
-0.01941988617181778,
0.01002785935997963,
-0.37221530079841614,
0.08297813683748245,
-0.07937028259038925,
0.1684163510799408,
0.055957045406103134,
-0.20451898872852325,
0.04558918997645378,
0.07614870369434357,
0.04630766808986664,
-0.21787911653518677,
0.01362588256597519,
0.29317188262939453,
0.0406109057366848
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. SummaryClinical characteristics.The spectrum of propionic acidemia (PA) ranges from neonatal-onset to late-onset disease.Neonatal-onset PA, the most common form, is characterized by a healthy newborn with poor feeding and decreased arousal in the first few days of life, followed by progressive encephalopathy of unexplained origin. Without prompt diagnosis and management, this is followed by progressive encephalopathy manifesting as lethargy, seizures, or coma that can result in death. It is frequently accompanied by metabolic acidosis with anion gap, lactic acidosis, ketonuria, hypoglycemia, hyperammonemia, and cytopenias.Individuals with late-onset PA may remain asymptomatic and suffer a metabolic crisis under catabolic stress (e.g., illness, surgery, fasting) or may experience a more insidious onset with the development of multiorgan complications including vomiting, protein intolerance, failure to thrive, hypotonia, developmental delays or regression, movement disorders, or cardiomyopathy.Isolated cardiomyopathy | [
0.022553734481334686,
-0.04404802247881889,
-0.1551186889410019,
-0.2443075329065323,
0.06202949211001396,
-0.09262079745531082,
-0.11251503229141235,
-0.2381645292043686,
-0.14108072221279144,
-0.10067925602197647,
0.09655385464429855,
-0.05892537161707878,
-0.02936406433582306,
0.08922629803419113,
-0.15568609535694122,
0.02796105295419693,
0.05065781995654106,
0.03368878364562988,
-0.16595503687858582,
-0.2196701318025589,
0.03595469146966934,
-0.2079436033964157,
-0.07937732338905334,
0.10440551489591599,
0.28628450632095337,
-0.0710274800658226,
0.13449403643608093,
-0.26515883207321167,
0.23044843971729279,
0.12383466213941574,
0.01608836092054844,
0.11377983540296555,
0.2147960066795349,
-0.43737247586250305,
-0.05009295418858528,
-0.14199474453926086,
-0.010847510769963264,
-0.27512046694755554,
0.112592913210392,
-0.30846184492111206,
0.22260677814483643,
-0.24536655843257904,
0.23111513257026672,
-0.0916294977068901,
0.1657133400440216,
-0.0189703069627285,
-0.10306978970766068,
-0.015757203102111816,
-0.15259751677513123,
0.2515909969806671,
0.2760791480541229,
-0.11508737504482269,
-0.2720242738723755,
0.09350380301475525,
0.12126566469669342,
-0.18989942967891693,
-0.09594829380512238,
-0.017476515844464302,
-0.13638991117477417,
0.2651447355747223,
0.16385610401630402,
-0.12985718250274658,
-0.16494350135326385,
-0.3121914863586426,
0.06686671078205109,
-0.11873619258403778,
-0.07971692830324173,
0.1228550374507904,
0.14862355589866638,
-0.14434456825256348,
0.056654926389455795,
-0.10657752305269241,
-0.09874241799116135,
0.22526714205741882,
-0.018731577321887016,
0.1525208204984665,
0.09400611370801926,
0.10673778504133224,
-0.19761306047439575,
-0.3209945559501648,
-0.3178618252277374,
-0.03300325572490692,
0.019692452624440193,
-0.18128900229930878,
-0.14893141388893127,
-0.037249259650707245,
0.44524282217025757,
0.05517693608999252,
-0.013133003376424313,
0.16540180146694183,
0.1393653005361557,
-0.029980557039380074,
-0.1695406585931778,
-0.024742942303419113,
0.13001762330532074,
0.030658483505249023,
0.268877238035202,
-0.005868542939424515,
-0.3384663760662079,
0.07813460379838943,
0.06983273476362228,
0.10112643986940384,
-0.0840240940451622,
0.09426842629909515,
-0.1759062111377716,
0.1488066166639328,
-0.14748063683509827,
-0.07924474030733109,
-0.11499961465597153,
0.10656341165304184,
0.2054734081029892,
-0.30262917280197144,
0.20869852602481842,
-0.06080006808042526,
-0.5799021124839783,
0.048846203833818436,
-0.19261020421981812,
0.38302722573280334,
0.03810550644993782,
0.017176220193505287,
0.10876965522766113,
0.05344238504767418,
-0.007028953637927771,
-0.005532931070774794,
-0.10550102591514587,
0.011908064596354961,
0.0806540697813034,
0.10540325194597244,
0.24601814150810242,
-0.16420480608940125,
0.06084030121564865,
-0.015981247648596764,
0.009354387409985065,
-0.18553346395492554,
0.3991679251194,
0.02966594696044922,
-0.2848483920097351,
-0.36969003081321716,
-0.024647986516356468,
-0.06575755774974823,
0.07855786383152008,
0.1892857700586319,
0.2972553074359894,
0.09319832921028137,
0.2809573709964752,
-0.07312137633562088,
0.2752075791358948,
-0.0795319452881813,
0.18019041419029236,
-0.05915364250540733,
-0.18221822381019592,
-0.338507741689682,
0.1692122220993042,
0.046872496604919434,
-0.18978314101696014,
0.19940921664237976,
0.14820390939712524,
0.21075370907783508,
-0.135376438498497,
0.029678955674171448,
-0.08822682499885559,
-0.0701356902718544,
0.023526815697550774,
-0.06174634397029877,
-0.2824064791202545,
-0.07334905862808228,
-0.5099214911460876,
-0.10715833306312561,
-0.1818113476037979,
-0.10046751797199249,
-0.01476602628827095,
0.09554415196180344,
0.013598429970443249,
-0.028359340503811836,
-0.0010414832504466176,
0.061279214918613434,
-0.11473283916711807,
0.004902182146906853,
-0.03629700094461441,
0.24257294833660126,
0.21408934891223907,
-0.01750277914106846,
-0.471416175365448,
0.06657560914754868,
-0.07399912178516388,
-0.09999121725559235,
0.07152147591114044,
0.26131588220596313,
0.013138975948095322,
0.2611112892627716,
0.14347292482852936,
0.362613707780838,
0.033901579678058624,
0.2322714775800705,
-0.16331277787685394,
-0.22932910919189453,
0.26475387811660767,
-0.06480288505554199,
-0.1341722309589386,
0.01342017948627472,
-0.14454668760299683,
-0.17382122576236725,
0.14115813374519348,
-0.18810710310935974,
-0.04922249913215637,
-0.2479781210422516,
0.0854492112994194,
-0.03335621580481529,
0.10654734820127487,
0.1381068229675293,
-0.20132851600646973,
0.3088667392730713,
-0.31284409761428833,
-0.053410619497299194,
-0.2833991050720215,
-0.05929233133792877,
0.07942996919155121,
-0.027993254363536835,
0.037696488201618195,
0.2426760494709015,
-0.0986311212182045,
0.061095740646123886,
0.04572470858693123,
-0.28617772459983826,
-0.13993734121322632,
-0.042151764035224915,
-0.38231223821640015,
-0.29158276319503784,
0.23223474621772766,
-0.3115687966346741,
-0.1926482915878296,
0.14600102603435516,
-0.11130566149950027,
0.2365579456090927,
-0.035505298525094986,
-0.1745855063199997,
-0.1447886824607849,
0.349866658449173,
-0.18511398136615753,
-0.07402050495147705,
-0.5439063906669617,
-0.2557978928089142,
0.04354969784617424,
0.12450966238975525,
0.05644045025110245,
-0.009557560086250305,
-0.002087099477648735,
0.17343512177467346,
0.07147236913442612,
0.2043246179819107,
0.008723529987037182,
0.057684049010276794,
0.024271776899695396,
0.14659585058689117,
-0.43760591745376587,
-0.12237812578678131,
0.1645447313785553,
0.18633735179901123,
0.07513265311717987,
-0.09677126258611679,
-0.14095169305801392,
0.24416032433509827,
-0.013046778738498688,
0.0405774749815464,
0.24787405133247375,
-0.11832868307828903,
-0.058819495141506195,
0.25213223695755005,
-0.054335445165634155,
-0.2837461829185486,
-0.02665637619793415,
0.2789956033229828,
0.15995685756206512,
0.12628969550132751,
-0.31007683277130127,
-0.1782703846693039,
0.1419990360736847,
0.14628641307353973,
-0.08697695285081863,
-0.02082115411758423,
-0.1973753124475479,
0.22268715500831604,
0.01218470185995102,
-0.05313735827803612,
0.15486076474189758,
0.21537575125694275,
0.052519336342811584,
0.08516576886177063,
-0.0827493891119957,
0.19532610476016998,
0.03547593206167221,
0.18177324533462524,
-0.2309504747390747,
-0.06438115984201431,
0.24490033090114594,
0.15494756400585175,
-0.09707363694906235,
0.11003066599369049,
0.021143866702914238,
0.17322611808776855,
-0.029024815186858177,
0.1282203197479248,
0.29768621921539307,
0.046187158674001694,
-0.3133266866207123,
0.025838816538453102,
-0.14288854598999023,
-0.059333428740501404,
0.14279310405254364,
0.20309840142726898,
0.010553909465670586,
-0.09501590579748154,
-0.2261282503604889,
-0.03192978352308273,
-0.053780727088451385,
-0.02798534370958805,
0.11435777693986893,
0.1899510622024536,
0.18897759914398193,
0.26498880982398987,
-0.09985101222991943,
0.007918317802250385,
0.06771567463874817,
0.07491017878055573,
-0.4694306552410126,
-0.0545307919383049,
-0.015129873529076576,
-0.02770298533141613,
0.014526241458952427,
0.08072240650653839,
-0.10581958293914795,
0.1539957970380783,
0.1406424343585968,
-0.20752876996994019,
0.20683008432388306,
-0.29920321702957153,
0.3735027313232422,
-0.0515698567032814,
-0.0534805990755558,
0.013368108309805393,
0.1550246775150299,
-0.5192955732345581,
-0.013470345176756382,
-0.312025785446167,
-0.4181364178657532,
0.08082997053861618,
-0.1499505341053009,
0.32833927869796753,
-0.06607154756784439,
-0.037500448524951935,
-0.05608821660280228,
0.13938525319099426,
-0.24693992733955383,
-0.1549798548221588,
0.13004674017429352,
-0.10143426805734634,
-0.17655052244663239,
0.07862068712711334,
0.18892766535282135,
0.10940632224082947,
-0.31523555517196655,
0.08539576828479767,
0.17604048550128937,
-0.18357230722904205,
0.0100533626973629,
-0.28648340702056885,
-0.11238007992506027,
-0.1734897792339325,
0.134294331073761,
-0.06117575988173485,
0.04664688929915428,
0.11422716081142426,
0.04478415474295616,
0.17884835600852966,
-0.12214101850986481,
0.29911503195762634,
-0.1288834810256958,
0.02713150903582573,
-0.28756096959114075,
-0.13027691841125488,
0.261204332113266,
0.08465198427438736,
0.12051236629486084,
-0.01683531142771244,
0.059465132653713226,
-0.020477399230003357,
-0.13975554704666138,
0.3661525845527649,
0.36185282468795776,
-0.5846662521362305,
0.0033818536903709173,
0.18658694624900818,
-0.15635977685451508,
0.2433573454618454,
0.16949628293514252,
0.001918574795126915,
-0.008343709632754326,
0.23552948236465454,
-0.13418048620224,
0.09590613096952438,
0.04093928635120392,
0.16817907989025116,
0.18088874220848083,
0.13459379971027374,
0.07015595585107803,
0.11001908779144287,
0.2549448311328888,
0.056336659938097,
-0.2546296715736389,
0.023774361237883568,
-0.07651063799858093,
-0.08795465528964996,
-0.04719218984246254,
-0.22906245291233063,
-0.2003142535686493,
-0.08687539398670197,
-0.10200827568769455,
0.09344750642776489,
0.17504021525382996,
-0.04441611096262932,
0.02973971515893936,
-0.05687783285975456,
-0.0018886065809056163,
0.11899612843990326,
-0.20305152237415314,
0.04335922375321388,
0.08840084820985794,
-0.11303775757551193,
0.09342789649963379,
0.19633637368679047,
0.2182329148054123,
-0.14812609553337097,
-0.22079120576381683,
0.04659871384501457,
0.14474523067474365,
0.13041549921035767,
-0.2559579610824585,
0.01586509868502617,
-0.2908206284046173,
-0.17884483933448792,
0.08663059026002884,
0.12862451374530792,
-0.08416714519262314,
-0.08353600651025772,
-0.2593337595462799,
0.3527308702468872,
0.42493268847465515,
0.23893293738365173,
-0.05234602093696594,
0.1600925475358963,
0.2123282551765442,
-0.15310974419116974,
-0.07199040800333023,
0.08811573684215546,
0.1093764454126358,
0.19517183303833008,
0.1513635367155075,
-0.1323043555021286,
0.09452616423368454,
-0.04179812967777252,
-0.22655600309371948,
0.2369493544101715,
0.10719292610883713,
-0.2516625225543976,
-0.27929309010505676,
0.009253280237317085,
-0.1572413295507431,
0.06465964019298553,
0.02390589937567711,
-0.07582169026136398,
0.11173857003450394,
0.07150517404079437,
-0.1553933471441269,
0.16440555453300476,
-0.2488621324300766,
-0.17469348013401031,
-0.20396548509597778,
-0.1643008440732956,
-0.06263508647680283,
0.019670752808451653,
0.09113804996013641,
-0.25667619705200195,
0.22497636079788208,
-0.08121781796216965,
-0.2413553148508072,
0.17132072150707245,
-0.3760862648487091,
0.03451702371239662,
0.37424957752227783,
0.05320728197693825,
-0.04199264571070671,
-0.1058640256524086,
-0.07182684540748596,
0.33760806918144226,
-0.07180266082286835,
-0.35575762391090393,
0.006924435496330261,
-0.05033291131258011,
0.022043127566576004,
0.036356352269649506,
-0.27808886766433716,
-0.12696130573749542,
-0.24304413795471191,
-0.10942836850881577,
-0.10822098702192307,
-0.01993359811604023,
-0.036733243614435196,
-0.24433858692646027,
-0.18954820930957794,
0.21195140480995178,
0.15875136852264404,
0.0740601047873497,
0.026580603793263435,
-0.1380741447210312,
0.14799755811691284,
-0.21815557777881622,
0.22588306665420532,
0.33776476979255676,
0.046359188854694366,
-0.37790873646736145,
0.18421772122383118,
0.026473714038729668,
0.30214908719062805,
0.009120653383433819,
0.20911237597465515,
-0.027535976842045784,
-0.018562618643045425,
0.28638342022895813,
-0.09566502273082733,
-0.13558320701122284,
0.2040555626153946,
0.07020297646522522,
-0.28565606474876404,
0.1609167903661728,
0.14752082526683807,
0.001146053895354271,
0.01982065849006176,
-0.10552199929952621,
0.22192804515361786,
-0.11831562221050262,
0.004662122577428818,
0.04644867405295372,
-0.08702679723501205,
0.14643007516860962,
-0.35292568802833557,
0.19143708050251007,
0.22087007761001587,
0.11682845652103424,
0.11313490569591522,
-0.10801376402378082,
0.03282691538333893,
-0.3080272972583771,
0.08277757465839386,
-0.10509924590587616,
-0.12286124378442764,
-0.03693177551031113,
-0.2736467719078064,
-0.17910605669021606,
-0.3556031882762909,
0.04412641376256943,
-0.32518795132637024,
-0.045696258544921875,
-0.25183627009391785,
0.14741359651088715,
0.0006451826193369925,
0.19932451844215393,
0.011385943740606308,
-0.02378467470407486,
-0.12176674604415894,
-0.11449218541383743,
0.12334658950567245,
-0.00583121320232749,
0.21632373332977295,
-0.009014426730573177,
-0.243684783577919,
0.20668716728687286,
-0.20181551575660706,
-0.438496857881546,
-0.15206047892570496,
0.18252523243427277,
-0.021817486733198166,
-0.2795248329639435,
0.11011995375156403,
-0.290438711643219,
0.13228115439414978,
0.02923366241157055,
0.07556995749473572,
0.09797114133834839,
0.41759464144706726,
0.06534506380558014,
-0.11919450759887695,
-0.2767791152000427,
0.053259193897247314,
0.005581223871558905,
0.10934431850910187,
-0.29763779044151306,
0.2847711443901062,
-0.26730793714523315,
0.09913060814142227,
0.07737406343221664,
0.4983077943325043,
0.3956688940525055,
0.15242312848567963,
-0.1552969515323639,
-0.09937988221645355,
-0.04606523737311363,
0.21729713678359985,
-0.3228444457054138,
-0.08006903529167175,
-0.01184358261525631,
0.2773571014404297,
0.15509755909442902,
0.23756520450115204,
-0.04940477013587952,
-0.1011623740196228,
-0.02124050259590149,
0.23133650422096252,
0.048893362283706665,
0.1614864468574524,
-0.13910269737243652,
0.18597397208213806,
0.08988268673419952,
0.1694776713848114,
-0.12672866880893707,
-0.13780653476715088,
0.09232785552740097,
-0.08149780333042145,
-0.26312750577926636,
0.17435751855373383,
-0.028654180467128754,
0.052686795592308044,
0.3143750727176666,
0.024832669645547867,
-0.04499157518148422,
-0.27374523878097534,
-0.09367942810058594,
0.16502457857131958,
0.2029578685760498,
-0.22217531502246857,
0.06572799384593964,
-0.4050008952617645,
0.1518801748752594,
-0.08328524976968765,
0.18189314007759094,
-0.3308684527873993,
0.16635429859161377,
-0.26573407649993896,
-0.22902019321918488,
-0.02756810560822487,
-0.1677686870098114,
0.1615755259990692,
-0.25389450788497925,
-0.044013094156980515,
0.2190566062927246,
0.38432225584983826,
-0.15545205771923065,
-0.05099577084183693,
-0.12310522794723511,
0.27863484621047974,
0.1398041993379593,
0.021414026618003845,
0.2697031795978546,
0.15155605971813202,
-0.19895443320274353,
-0.28284308314323425,
0.29730290174484253,
0.21748296916484833,
-0.02752997726202011,
0.025064170360565186,
-0.2463223785161972,
-0.22312091290950775,
0.05610523372888565,
-0.14102201163768768,
0.13556954264640808,
0.04639770835638046,
0.12043026834726334,
0.029154876247048378,
0.18005599081516266,
-0.09453082084655762,
0.5341162085533142,
0.058724988251924515,
-0.46562430262565613,
-0.13617438077926636,
0.11254746466875076,
0.26444005966186523,
0.15340936183929443,
0.0802021250128746,
-0.07091537863016129,
0.2938503324985504,
-0.45157450437545776,
0.12715649604797363,
-0.07219982892274857,
0.1206808090209961,
0.11556754261255264,
0.0040442077443003654,
0.05809815973043442,
0.49229130148887634,
-0.2588196098804474,
-0.4152016341686249,
-0.06037282571196556,
-0.1405106782913208,
0.1348234862089157,
0.11364546418190002,
0.15864381194114685,
-0.10517501085996628,
-0.19341056048870087,
0.11583305895328522,
-0.15729360282421112,
0.0644771158695221,
-0.06948873400688171,
-0.08512318134307861,
-0.26657047867774963,
0.01823296584188938,
0.1749776005744934,
0.00234506418928504,
0.23244160413742065,
-0.07799898833036423,
0.16656233370304108,
-0.19984257221221924,
-0.21006208658218384,
0.013059561140835285,
0.0016931637655943632,
0.07981148362159729,
0.1530652791261673,
-0.014887991361320019,
-0.0058702812530100346,
-0.06754385679960251,
0.07805217057466507,
0.1732785403728485,
-0.08103235065937042,
-0.18553045392036438,
-0.013758761808276176,
-0.43207719922065735,
0.19424192607402802,
-0.07168789207935333,
0.08290799707174301,
-0.010207941755652428,
0.09573536366224289,
-0.11734794080257416,
-0.3147185146808624,
-0.10028921812772751,
0.2712661921977997,
0.08242350816726685,
-0.056855011731386185,
-0.10557397454977036,
0.29403942823410034,
-0.03514578565955162,
-0.14824800193309784,
-0.04280790686607361,
-0.18820123374462128,
0.13093328475952148,
0.07872596383094788,
0.008649769239127636,
0.23837806284427643,
0.08819340914487839,
0.12339907884597778,
-0.09866919368505478,
-0.21223637461662292,
-0.05996157228946686,
-0.0014475451316684484,
-0.1691458374261856,
0.09135086089372635,
-0.0004658638790715486,
0.13855090737342834,
-0.26044192910194397,
0.21472704410552979,
0.15597611665725708,
0.19201163947582245
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. accompanied by metabolic acidosis with anion gap, lactic acidosis, ketonuria, hypoglycemia, hyperammonemia, and cytopenias.Individuals with late-onset PA may remain asymptomatic and suffer a metabolic crisis under catabolic stress (e.g., illness, surgery, fasting) or may experience a more insidious onset with the development of multiorgan complications including vomiting, protein intolerance, failure to thrive, hypotonia, developmental delays or regression, movement disorders, or cardiomyopathy.Isolated cardiomyopathy can be observed on rare occasion in the absence of clinical metabolic decompensation or neurocognitive deficits.Manifestations of neonatal and late-onset PA over time can include growth impairment, intellectual disability, seizures, basal ganglia lesions, pancreatitis, and cardiomyopathy. Other rarely reported complications include optic atrophy, hearing loss, premature ovarian insufficiency, and chronic renal failure.Diagnosis/testing.PA is caused by deficiency of propionyl-CoA carboxylase (PCC), the enzyme that catalyzes the conversion of propionyl | [
-0.01301207859069109,
-0.02458534948527813,
-0.17284415662288666,
-0.23872415721416473,
0.15864528715610504,
-0.05283830314874649,
-0.011413219384849072,
-0.27407124638557434,
0.07543627917766571,
-0.16241483390331268,
0.2188490927219391,
0.01978902332484722,
-0.11398269236087799,
0.0805993527173996,
-0.2724393308162689,
0.1326351761817932,
-0.0566842257976532,
0.05448601394891739,
-0.18617428839206696,
-0.16758868098258972,
-0.1095161885023117,
-0.15728183090686798,
0.10785800963640213,
0.02648528851568699,
0.3438485860824585,
-0.08481281995773315,
0.06130767613649368,
-0.31524208188056946,
0.16709809005260468,
0.1573306769132614,
0.13374333083629608,
-0.11283983290195465,
0.31618136167526245,
-0.32479751110076904,
0.029469365254044533,
-0.26750844717025757,
-0.14305077493190765,
-0.40059325098991394,
0.12007413804531097,
-0.22995547950267792,
0.07309670746326447,
-0.10969486087560654,
0.3638874590396881,
-0.09896565973758698,
0.30617761611938477,
-0.10431651771068573,
0.028106343001127243,
-0.0964302197098732,
-0.09586585313081741,
0.3425230085849762,
0.24469919502735138,
-0.2725508213043213,
-0.2675859332084656,
0.06322261691093445,
0.24279195070266724,
-0.08641456812620163,
-0.19369836151599884,
0.059995152056217194,
-0.12783674895763397,
0.3798735737800598,
0.25336402654647827,
-0.06902365386486053,
-0.1890447735786438,
-0.3995019197463989,
0.1289900690317154,
-0.1305856853723526,
-0.06968750059604645,
0.16287614405155182,
0.20170721411705017,
0.03853391483426094,
0.17071786522865295,
-0.15218263864517212,
0.06453049182891846,
0.2502461075782776,
-0.09055005013942719,
0.09890193492174149,
0.13131119310855865,
-0.00021908525377511978,
-0.0948772132396698,
-0.24855047464370728,
-0.3053515553474426,
-0.04973733797669411,
0.053104057908058167,
-0.26184970140457153,
-0.23588675260543823,
0.13237540423870087,
0.2760271430015564,
-0.04998111352324486,
-0.09677433967590332,
0.06902339309453964,
0.21569795906543732,
-0.03692847117781639,
-0.030422650277614594,
0.12157239019870758,
0.05252336338162422,
0.014994030818343163,
0.4108586311340332,
0.01510534156113863,
-0.2714153528213501,
0.047762468457221985,
0.12757299840450287,
-0.06258668750524521,
0.0019284915179014206,
0.08340809494256973,
-0.23239435255527496,
0.17656728625297546,
-0.26041650772094727,
-0.1464873105287552,
-0.1422615945339203,
0.10024280101060867,
0.30051156878471375,
-0.2683468759059906,
0.18903031945228577,
-0.052262015640735626,
-0.46404898166656494,
0.18064361810684204,
-0.13709793984889984,
0.3946594297885895,
0.08233018964529037,
0.08380135893821716,
0.036108773201704025,
0.062458671629428864,
0.050852108746767044,
0.3165265619754791,
0.0031846365891397,
0.04359191283583641,
0.09310739487409592,
-0.002402764745056629,
0.31784528493881226,
0.031196607276797295,
0.08102720230817795,
0.0006908774957992136,
-0.059433434158563614,
-0.15452279150485992,
0.2703593373298645,
-0.025544846430420876,
-0.4898536503314972,
-0.45573171973228455,
-0.008995316922664642,
0.08414272218942642,
0.08351119607686996,
0.16954804956912994,
0.19403119385242462,
0.23371651768684387,
0.3237987160682678,
-0.054243095219135284,
0.33117783069610596,
-0.05343952029943466,
0.12873242795467377,
-0.07844093441963196,
-0.11985280364751816,
-0.4871842861175537,
-0.022210976108908653,
-0.021199537441134453,
-0.15999506413936615,
0.09904499351978302,
0.06828688085079193,
0.15945525467395782,
-0.22226597368717194,
-0.07909514009952545,
0.24103987216949463,
-0.03187311440706253,
-0.028697790578007698,
0.04355502873659134,
-0.16895705461502075,
-0.008514766581356525,
-0.3403131663799286,
-0.0616254098713398,
0.16791464388370514,
-0.12478282302618027,
-0.020237881690263748,
-0.031087419018149376,
-0.06485229730606079,
0.0738905668258667,
0.008147573098540306,
0.09943994134664536,
-0.01676718331873417,
0.030247902497649193,
0.08285912126302719,
0.13473375141620636,
0.1968497335910797,
0.06263508647680283,
-0.5617345571517944,
0.008150803856551647,
0.022295214235782623,
-0.15449835360050201,
-0.029673831537365913,
0.11989078670740128,
0.007608349435031414,
0.22317257523536682,
0.04630712792277336,
0.22024394571781158,
0.11197494715452194,
0.3553154766559601,
-0.2051321417093277,
-0.19571428000926971,
0.19881834089756012,
-0.01557158026844263,
-0.1674022674560547,
-0.10293829441070557,
0.010932182893157005,
-0.25694364309310913,
0.09674970805644989,
-0.04699297994375229,
-0.19149447977542877,
-0.10589856654405594,
-0.08545313775539398,
-0.14162537455558777,
0.04307129979133606,
0.06469925493001938,
-0.2278803586959839,
0.3828609883785248,
-0.2899164855480194,
-0.11053862422704697,
-0.26487791538238525,
-0.09954436123371124,
-0.1211126446723938,
0.04048207029700279,
0.011945857666432858,
0.23770329356193542,
0.032350219786167145,
-0.03441600874066353,
0.13140928745269775,
-0.29826226830482483,
-0.21514785289764404,
0.013019777834415436,
-0.305776447057724,
-0.27404484152793884,
0.020533092319965363,
-0.28044214844703674,
-0.25375789403915405,
0.17345306277275085,
-0.04168761894106865,
0.15870197117328644,
0.06528254598379135,
-0.2530032694339752,
-0.14098025858402252,
0.4313606321811676,
-0.07186119258403778,
-0.11624769121408463,
-0.4277150630950928,
-0.2027239352464676,
0.12740659713745117,
0.05389612540602684,
-0.04503612965345383,
0.02398628182709217,
-0.03143462911248207,
0.2809176743030548,
-0.12004044651985168,
0.1918630748987198,
-0.1182374507188797,
0.2532384693622589,
-0.001122092129662633,
0.07193107157945633,
-0.4464236795902252,
-0.12279775738716125,
0.2694230377674103,
0.11660561710596085,
0.021630829200148582,
-0.08921574056148529,
-0.021926088258624077,
0.11893491446971893,
-0.0034718213137239218,
-0.07932887226343155,
0.18650025129318237,
-0.04807448759675026,
-0.21830876171588898,
0.1709250658750534,
-0.08007054775953293,
-0.14523957669734955,
0.05493968725204468,
0.2430335432291031,
0.25301989912986755,
-0.0011817787308245897,
-0.4584514796733856,
-0.29752448201179504,
0.060582440346479416,
0.24065332114696503,
0.10333535820245743,
0.15252350270748138,
-0.23982645571231842,
0.1360331028699875,
-0.05915416032075882,
0.04354115203022957,
0.27265408635139465,
0.08346223086118698,
0.05275210365653038,
-0.15267735719680786,
-0.2363503873348236,
0.13226665556430817,
0.02044260874390602,
0.22107277810573578,
-0.23939678072929382,
-0.1213221549987793,
0.16992251574993134,
0.00728886341676116,
0.05879981070756912,
0.020932920277118683,
0.08271685242652893,
0.12373492121696472,
-0.06823422014713287,
0.18035264313220978,
0.3220328390598297,
0.05498505383729935,
-0.3014456629753113,
0.1032353937625885,
-0.14554695785045624,
-0.14776307344436646,
0.035172127187252045,
0.4555741250514984,
-0.08372417837381363,
-0.13227587938308716,
-0.30840665102005005,
-0.08419877290725708,
-0.1854793280363083,
-0.074399434030056,
0.17060324549674988,
0.23033489286899567,
0.0846029743552208,
0.26194268465042114,
-0.21930865943431854,
-0.020071029663085938,
0.054830390959978104,
0.046073123812675476,
-0.34380272030830383,
-0.003611432621255517,
-0.05231311917304993,
0.11304961144924164,
0.20724330842494965,
-0.037496622651815414,
-0.05096754431724548,
0.29801541566848755,
0.13914978504180908,
-0.16653650999069214,
0.12876129150390625,
-0.20224404335021973,
0.4640353322029114,
0.16574476659297943,
0.059647101908922195,
-0.06656456738710403,
0.1880652904510498,
-0.33449915051460266,
-0.10128243267536163,
-0.30354544520378113,
-0.25499945878982544,
0.25996240973472595,
0.10521825402975082,
0.27203798294067383,
-0.016152886673808098,
-0.0916018933057785,
-0.10866658389568329,
0.24455496668815613,
-0.19462883472442627,
-0.16015252470970154,
0.35090798139572144,
-0.04094335436820984,
-0.32150930166244507,
0.17973287403583527,
0.30095309019088745,
0.16832643747329712,
-0.25687241554260254,
0.19999819993972778,
0.3105415403842926,
-0.324785977602005,
-0.04126632213592529,
-0.42107605934143066,
0.007782619912177324,
0.03725530207157135,
0.21788519620895386,
0.08201674371957779,
0.014976302161812782,
0.20121562480926514,
0.21911582350730896,
0.22946485877037048,
-0.1390773355960846,
0.21437664330005646,
-0.2533259391784668,
0.04423495754599571,
-0.34273427724838257,
0.06954246759414673,
0.22038830816745758,
-0.015246585942804813,
0.12069184333086014,
0.1217985525727272,
0.08471736311912537,
0.08718715608119965,
-0.010293382219970226,
0.4037318825721741,
0.25103649497032166,
-0.7741909623146057,
-0.09517178684473038,
0.191361665725708,
-0.06209215521812439,
0.09472449123859406,
0.17295874655246735,
0.16734957695007324,
0.04097925126552582,
0.251923531293869,
-0.2129451334476471,
0.14256393909454346,
0.1682576686143875,
0.05521797761321068,
0.20838409662246704,
0.023275457322597504,
0.10637594014406204,
-0.09651447832584381,
0.21216030418872833,
0.20912425220012665,
-0.020137429237365723,
0.04324572905898094,
-0.04405267536640167,
-0.2537688612937927,
-0.07036960870027542,
-0.03578741475939751,
-0.0997479036450386,
-0.1325235813856125,
-0.1492099165916443,
0.05826816335320473,
0.3043980002403259,
-0.13937996327877045,
-0.21881219744682312,
0.10243693739175797,
0.051346469670534134,
-0.06481891870498657,
-0.22385095059871674,
0.008051243610680103,
0.11963904649019241,
-0.17196212708950043,
0.17497286200523376,
0.12017232924699783,
0.18939240276813507,
-0.01783088780939579,
-0.10212734341621399,
0.01742199808359146,
0.3046390116214752,
0.15915870666503906,
-0.3136225640773773,
0.05350504070520401,
-0.10685635358095169,
-0.19409455358982086,
0.17024046182632446,
-0.014354435727000237,
-0.11931692063808441,
-0.1756969690322876,
-0.11586736887693405,
0.3756474554538727,
0.4837135970592499,
0.2951796054840088,
-0.065749391913414,
0.15115489065647125,
0.08600857108831406,
-0.19134479761123657,
0.050130125135183334,
0.07568974792957306,
0.07495822757482529,
0.09728634357452393,
0.17781832814216614,
-0.08667450398206711,
-0.06389717012643814,
-0.04675481840968132,
-0.22801604866981506,
0.11507905274629593,
0.22160299122333527,
-0.10364659875631332,
-0.11982423067092896,
0.11052597314119339,
-0.20088568329811096,
0.05555713176727295,
0.1643008291721344,
-0.04047797620296478,
0.2625555098056793,
0.2645195424556732,
-0.09618684649467468,
0.27302518486976624,
-0.4040810465812683,
-0.08177410066127777,
-0.3024655878543854,
-0.11873488873243332,
0.029445413500070572,
-0.08310075104236603,
0.05502714216709137,
-0.19305773079395294,
-0.018146483227610588,
-0.1451888531446457,
-0.3076252043247223,
0.17198625206947327,
-0.10328631103038788,
-0.09550025314092636,
0.4703276753425598,
0.1464369148015976,
-0.02171262353658676,
0.01912430115044117,
0.014511747285723686,
0.4012735188007355,
-0.14043962955474854,
-0.31345394253730774,
0.11066430807113647,
0.011451007798314095,
0.11563058197498322,
-0.018322400748729706,
-0.2321723848581314,
-0.2266422063112259,
-0.2286260724067688,
0.07809692621231079,
-0.030342809855937958,
0.06336167454719543,
-0.04381084814667702,
-0.19267210364341736,
-0.18109969794750214,
0.37870922684669495,
0.08370978385210037,
-0.012664319947361946,
0.14060600101947784,
-0.15951599180698395,
0.06997284293174744,
-0.4011686146259308,
0.21840669214725494,
0.2750312387943268,
0.10554471611976624,
-0.4084084928035736,
0.14570878446102142,
0.08537183701992035,
0.27052873373031616,
-0.06266579777002335,
0.21513359248638153,
0.06159402057528496,
0.059826020151376724,
0.2550888955593109,
0.018734581768512726,
-0.13834130764007568,
0.09813661128282547,
-0.2226669192314148,
-0.2640485465526581,
-0.0883735790848732,
0.1472753882408142,
-0.02090824767947197,
-0.020680636167526245,
-0.1820271611213684,
0.20781545341014862,
-0.012354698032140732,
-0.15635038912296295,
0.013934368267655373,
0.07382325828075409,
0.07605534046888351,
-0.27242398262023926,
0.13885527849197388,
0.15547554194927216,
0.20138852298259735,
0.12147751450538635,
-0.19378285109996796,
-0.09476359188556671,
-0.138449028134346,
-0.06481268256902695,
0.15355096757411957,
0.058957770466804504,
-0.15077678859233856,
-0.07346110790967941,
-0.13919055461883545,
-0.5505451560020447,
0.04312453791499138,
-0.1188671812415123,
-0.03570746257901192,
-0.2428542822599411,
0.17441326379776,
-0.11386211216449738,
0.19079871475696564,
-0.19079887866973877,
0.131028950214386,
-0.1694267988204956,
-0.24209614098072052,
0.18480335175991058,
0.089016392827034,
0.17062446475028992,
-0.20219743251800537,
-0.21882647275924683,
0.1470775604248047,
-0.18056946992874146,
-0.5302481055259705,
-0.14327900111675262,
0.15656666457653046,
0.025630785152316093,
-0.2511340081691742,
0.2509905695915222,
-0.22566629946231842,
0.16270102560520172,
-0.1020955815911293,
0.07532434910535812,
-0.017866818234324455,
0.39236927032470703,
0.02422165311872959,
-0.11892271786928177,
-0.23066291213035583,
0.03897380456328392,
-0.008809258230030537,
0.33311063051223755,
-0.2248944789171219,
0.10497737675905228,
-0.3200486898422241,
-0.10891364514827728,
0.15485866367816925,
0.26286762952804565,
0.31278300285339355,
0.003286261111497879,
-0.25732094049453735,
-0.06982980668544769,
0.027954889461398125,
0.1215863898396492,
-0.3374265134334564,
-0.1934603750705719,
0.016392327845096588,
0.29376220703125,
0.24343650043010712,
0.1255992352962494,
-0.20412561297416687,
-0.10116586089134216,
-0.1928790956735611,
0.36188727617263794,
0.09429409354925156,
0.10540205240249634,
0.009794099256396294,
0.27054688334465027,
0.05140772834420204,
0.12225291132926941,
-0.12263989448547363,
-0.2318873107433319,
0.0953746810555458,
0.028360895812511444,
-0.06426500529050827,
0.05725240707397461,
-0.009155209176242352,
-0.018237346783280373,
0.27012836933135986,
-0.010789332911372185,
0.016251100227236748,
-0.16099023818969727,
0.09207223355770111,
0.10081170499324799,
0.30892351269721985,
-0.3037406802177429,
0.12473680824041367,
-0.3163372278213501,
0.2185472697019577,
-0.2495328187942505,
0.12859241664409637,
-0.16289068758487701,
0.1960354596376419,
-0.1590486466884613,
-0.1942259669303894,
-0.1446484476327896,
-0.20516717433929443,
0.13154254853725433,
-0.3678513467311859,
-0.028304267674684525,
0.15078411996364594,
0.29328247904777527,
-0.2068805992603302,
-0.10014227032661438,
-0.0330020934343338,
0.2965984642505646,
-0.09388415515422821,
-0.012996988371014595,
0.24793915450572968,
0.24921713769435883,
0.006923001259565353,
-0.22553081810474396,
0.24592384696006775,
0.18678367137908936,
0.09569713473320007,
0.060088321566581726,
-0.3347076177597046,
-0.002970283618196845,
-0.03571905568242073,
-0.14836052060127258,
0.24497973918914795,
-0.051093071699142456,
-0.1353922039270401,
-0.2167944759130478,
0.12955120205879211,
0.004846406169235706,
0.5209452509880066,
0.2397676706314087,
-0.38312557339668274,
-0.1412981003522873,
-0.031721532344818115,
0.21226513385772705,
0.119223952293396,
0.0073725376278162,
0.028177425265312195,
0.2387198805809021,
-0.3481031656265259,
0.004050062969326973,
-0.15899239480495453,
0.22704832255840302,
0.25165149569511414,
-0.07779111713171005,
0.04982852563261986,
0.3972105085849762,
-0.39911022782325745,
-0.38808149099349976,
-0.029613925144076347,
-0.18434453010559082,
-0.03514603525400162,
0.10242379456758499,
0.28993603587150574,
-0.18294300138950348,
-0.2471218854188919,
0.035154614597558975,
-0.18550164997577667,
0.00038309741648845375,
-0.05542414262890816,
-0.15340067446231842,
-0.17569996416568756,
-0.12785466015338898,
0.27334144711494446,
0.01755765825510025,
0.14528082311153412,
-0.08705896139144897,
0.050814464688301086,
-0.028520211577415466,
-0.21180474758148193,
-0.03912579268217087,
0.13635607063770294,
-0.008787286467850208,
0.016218718141317368,
-0.0054753790609538555,
0.13565082848072052,
-0.04966335371136665,
0.01645612344145775,
0.17110317945480347,
-0.06552209705114365,
-0.31900525093078613,
-0.0782880112528801,
-0.37553033232688904,
0.18467523157596588,
-0.06357570737600327,
0.04902729019522667,
-0.027295811101794243,
0.16657280921936035,
0.04119860380887985,
-0.24616611003875732,
-0.1655600517988205,
0.20882713794708252,
0.040264736860990524,
-0.17965786159038544,
-0.15319925546646118,
0.1655063033103943,
-0.07191865891218185,
-0.11499179154634476,
-0.043751299381256104,
-0.041057195514440536,
-0.04278244078159332,
0.06727973371744156,
0.028035635128617287,
0.21426740288734436,
0.1020781621336937,
0.1664435714483261,
-0.10614986717700958,
-0.23021246492862701,
0.05175766348838806,
0.016623592004179955,
-0.22887539863586426,
-0.09268645942211151,
0.04880017042160034,
0.050088293850421906,
-0.20296142995357513,
0.309817910194397,
0.1539902538061142,
0.15722788870334625
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , or cardiomyopathy.Isolated cardiomyopathy can be observed on rare occasion in the absence of clinical metabolic decompensation or neurocognitive deficits.Manifestations of neonatal and late-onset PA over time can include growth impairment, intellectual disability, seizures, basal ganglia lesions, pancreatitis, and cardiomyopathy. Other rarely reported complications include optic atrophy, hearing loss, premature ovarian insufficiency, and chronic renal failure.Diagnosis/testing.PA is caused by deficiency of propionyl-CoA carboxylase (PCC), the enzyme that catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA. Newborns with PA tested by expanded newborn screening have elevated C3 (propionylcarnitine). Testing of urine organic acids in persons who are symptomatic or those detected by newborn screening reveals elevated 3-hydroxypropionate and the presence of methylcitrate, tiglylglycine, propionylglycine, and lactic acid. Testing of plasma amino acids reveals elevated glycine. Confirmation of the diagnosis relies on detection of biallelic pathogenic variants in PCC | [
-0.1330336183309555,
-0.07496292144060135,
-0.07681819051504135,
-0.2863346040248871,
0.33541133999824524,
0.0788058340549469,
-0.06316536664962769,
-0.2959672808647156,
0.19552145898342133,
-0.15212884545326233,
0.20816516876220703,
0.23527874052524567,
-0.1913621574640274,
0.0029953515622764826,
-0.12576688826084137,
0.19132941961288452,
0.024592414498329163,
0.08578339964151382,
-0.1478598713874817,
-0.11685777455568314,
-0.10420949757099152,
-0.2567318081855774,
-0.03287450224161148,
0.025107476860284805,
0.3543738126754761,
-0.0967765673995018,
0.1713603138923645,
-0.37731409072875977,
0.19871576130390167,
0.22344663739204407,
0.01640620082616806,
-0.20729325711727142,
0.1948952078819275,
-0.11557850241661072,
0.023696351796388626,
-0.18900011479854584,
-0.20721744000911713,
-0.5824090242385864,
-0.04165605083107948,
-0.05425724759697914,
0.0889091044664383,
0.04558422788977623,
0.34343400597572327,
-0.1151094138622284,
0.25430169701576233,
-0.1926247626543045,
0.07055970281362534,
-0.29385805130004883,
-0.0633254274725914,
0.18936888873577118,
0.341331422328949,
-0.4694187343120575,
-0.2724352777004242,
0.11949080228805542,
0.2151578962802887,
0.1980196088552475,
-0.24309539794921875,
-0.05271230265498161,
-0.07441695034503937,
0.355473130941391,
0.19383986294269562,
-0.05330102518200874,
-0.04084145277738571,
-0.390919029712677,
0.09989433735609055,
-0.23585307598114014,
0.16556885838508606,
0.14984546601772308,
0.3040952980518341,
0.15517973899841309,
0.06496456265449524,
-0.09449081122875214,
0.07004844397306442,
0.1728590428829193,
-0.11095208674669266,
0.025997882708907127,
0.11466190218925476,
-0.08910118788480759,
-0.11107338219881058,
-0.07707149535417557,
-0.16542473435401917,
0.012066327035427094,
-0.061367616057395935,
-0.16099834442138672,
-0.17506352066993713,
0.1559775322675705,
0.13720452785491943,
-0.07739479094743729,
-0.404999315738678,
-0.05524081364274025,
0.20172135531902313,
-0.11130368709564209,
0.22928641736507416,
0.03508264943957329,
-0.019783491268754005,
-0.18418167531490326,
0.4977369010448456,
0.1256571114063263,
-0.260026216506958,
0.052655335515737534,
0.13086649775505066,
-0.014233960770070553,
-0.0902784988284111,
-0.033583879470825195,
-0.3520674407482147,
0.013181772083044052,
-0.32592231035232544,
-0.1312313675880432,
-0.03231380879878998,
-0.10500882565975189,
0.23649223148822784,
-0.16100315749645233,
0.1211213693022728,
0.0005344707751646638,
-0.6016774773597717,
0.26574262976646423,
-0.07366935908794403,
0.29943424463272095,
0.037874605506658554,
0.2569356858730316,
-0.0014204679755493999,
-0.03786752000451088,
-0.05554450303316116,
0.49615129828453064,
0.0014979522675275803,
0.24687856435775757,
0.07568200677633286,
-0.12688788771629333,
0.4221079349517822,
0.09318637102842331,
0.1458299309015274,
0.020380428060889244,
0.06209801509976387,
-0.1521376222372055,
0.41324537992477417,
0.10561568289995193,
-0.3974255323410034,
-0.3073714077472687,
0.03410104662179947,
0.222855344414711,
0.17911218106746674,
0.15762959420681,
0.31470268964767456,
0.23650476336479187,
0.3272305130958557,
0.04008376598358154,
0.25025367736816406,
-0.22390374541282654,
0.43743613362312317,
0.021172601729631424,
0.13574132323265076,
-0.6503347158432007,
-0.18555033206939697,
-0.09617733210325241,
-0.14424456655979156,
0.08419457823038101,
-0.10057864338159561,
0.07724495232105255,
-0.1256396323442459,
-0.13625232875347137,
0.1313789039850235,
-0.15691086649894714,
-0.12487836927175522,
0.037366826087236404,
-0.01841389387845993,
-0.08031360059976578,
-0.4083399474620819,
-0.009569232352077961,
0.3709339499473572,
0.06541986018419266,
-0.1223045289516449,
-0.008010994642972946,
-0.029336819425225258,
0.09072258323431015,
0.2636781930923462,
-0.06456565856933594,
0.036450061947107315,
0.020710498094558716,
-0.03357489034533501,
0.05598022788763046,
0.13953135907649994,
0.17603425681591034,
-0.41735270619392395,
-0.004898709710687399,
-0.016662748530507088,
-0.18449299037456512,
-0.1601371169090271,
-0.15896177291870117,
-0.06603765487670898,
0.032812319695949554,
-0.013648341409862041,
0.07341577112674713,
0.1821746975183487,
0.3220459818840027,
-0.01008343230932951,
-0.26727843284606934,
0.2264307588338852,
0.0017174668610095978,
-0.1299167275428772,
-0.15728642046451569,
0.21596255898475647,
-0.37278124690055847,
0.1437167376279831,
-0.09616561233997345,
-0.15476489067077637,
0.02796814776957035,
-0.03217248618602753,
-0.29930824041366577,
0.07237216085195541,
0.1686467081308365,
-0.22765681147575378,
0.26120951771736145,
-0.2747116684913635,
-0.08286036550998688,
-0.1870580017566681,
-0.08911547809839249,
-0.05170663446187973,
-0.05188794061541557,
0.015061886981129646,
0.18517810106277466,
0.06159764155745506,
-0.004055761266499758,
0.08742435276508331,
-0.30227217078208923,
-0.09863132238388062,
0.0858481153845787,
-0.29368630051612854,
-0.2743214964866638,
0.04799659922719002,
-0.17371788620948792,
-0.2732591927051544,
0.14023998379707336,
-0.032573867589235306,
0.24248106777668,
0.021044965833425522,
-0.4067922830581665,
-0.32960399985313416,
0.31752485036849976,
-0.0585375539958477,
-0.03543892875313759,
-0.24923191964626312,
-0.16605331003665924,
-0.010920139029622078,
0.17198240756988525,
0.04222402349114418,
0.10347936302423477,
-0.14055432379245758,
0.17282140254974365,
-0.23325657844543457,
0.09231486916542053,
-0.17458757758140564,
0.3323138952255249,
0.020584458485245705,
0.0956975519657135,
-0.4656608998775482,
-0.24170996248722076,
0.1941024214029312,
0.25722628831863403,
-0.041775453835725784,
-0.04917598515748978,
0.06280932575464249,
0.23037873208522797,
0.003256174037232995,
0.03385934233665466,
-0.09450338035821915,
-0.05212513357400894,
-0.3962298631668091,
0.08474480360746384,
-0.14497244358062744,
-0.09214827418327332,
0.013265649788081646,
0.22662614285945892,
0.3649033010005951,
0.01131068542599678,
-0.28704407811164856,
-0.30122774839401245,
0.14520369470119476,
0.12865057587623596,
0.06226654350757599,
0.08575189113616943,
-0.2843323349952698,
0.3667376935482025,
-0.09255646169185638,
0.12046100944280624,
0.30549949407577515,
0.1011737808585167,
-0.11701085418462753,
-0.06027141213417053,
-0.2070559561252594,
0.26621076464653015,
0.0483722910284996,
0.24535445868968964,
-0.18987222015857697,
-0.13880714774131775,
0.1294747292995453,
0.13241633772850037,
-0.02527788281440735,
-0.05437283217906952,
0.14895787835121155,
0.2740343511104584,
-0.1069343090057373,
0.18656828999519348,
0.25306782126426697,
-0.2992115914821625,
-0.20374742150306702,
0.21870560944080353,
-0.12540565431118011,
-0.21318751573562622,
0.16601456701755524,
0.3155283033847809,
-0.15996558964252472,
-0.09262950718402863,
-0.3129688501358032,
-0.0498826764523983,
0.06399673968553543,
-0.19946083426475525,
0.2990349233150482,
0.11643480509519577,
0.061657700687646866,
0.44825607538223267,
-0.07577155530452728,
-0.038014914840459824,
-0.05698417127132416,
0.0055220602080225945,
-0.40990695357322693,
-0.02357073687016964,
-0.21789027750492096,
0.14916624128818512,
0.11056876927614212,
-0.14206933975219727,
0.1461782306432724,
0.40476739406585693,
-0.01138345617800951,
-0.1261524111032486,
0.39994531869888306,
-0.013307897374033928,
0.44012582302093506,
0.2841329574584961,
-0.05520600453019142,
-0.1239459365606308,
0.3072417676448822,
-0.25365182757377625,
-0.05122743546962738,
-0.29490208625793457,
-0.19248230755329132,
0.19738037884235382,
0.10337851196527481,
0.37552571296691895,
0.02842751331627369,
-0.09361577033996582,
-0.10900089889764786,
0.18453183770179749,
-0.10168486833572388,
-0.11683247983455658,
0.474461168050766,
-0.181300550699234,
-0.2525885999202728,
0.10288970172405243,
0.29987895488739014,
-0.10569267719984055,
-0.28209739923477173,
0.020961543545126915,
0.24558818340301514,
-0.21725919842720032,
-0.0003605846723075956,
-0.2542639970779419,
0.05059550702571869,
0.18944229185581207,
0.1868891417980194,
0.1546623259782791,
0.0045616053976118565,
0.07622459530830383,
0.21317505836486816,
0.2421177625656128,
-0.042317841202020645,
0.12535052001476288,
-0.24691838026046753,
-0.0767570286989212,
-0.1704472005367279,
0.033916786313056946,
0.056223753839731216,
0.08375611901283264,
-0.029288360849022865,
0.26184767484664917,
-0.06334125995635986,
0.009830226190388203,
0.30209121108055115,
0.3640168607234955,
0.22164848446846008,
-0.6858716011047363,
-0.07381555438041687,
0.17222748696804047,
0.10973156988620758,
0.17383930087089539,
-0.008190886117517948,
0.08968771249055862,
0.11602357029914856,
0.14256629347801208,
-0.18405281007289886,
0.24982309341430664,
0.12885266542434692,
0.0690910667181015,
0.3310699164867401,
0.018900010734796524,
0.04507402330636978,
0.10917234420776367,
0.13927707076072693,
0.18398579955101013,
-0.05168447270989418,
-0.03892471268773079,
0.0919112041592598,
-0.08604475855827332,
-0.1618364304304123,
-0.02045251429080963,
-0.08136739581823349,
-0.1273716241121292,
-0.20729921758174896,
0.15172074735164642,
0.2766582667827606,
-0.0595078207552433,
-0.13401025533676147,
0.32906416058540344,
0.17525990307331085,
-0.06180727481842041,
-0.20400531589984894,
-0.05453338101506233,
0.1225271075963974,
-0.11753018945455551,
0.06641807407140732,
0.08610016107559204,
0.18254052102565765,
-0.026844177395105362,
-0.03463873267173767,
-0.014951382763683796,
0.1344626098871231,
0.17853620648384094,
-0.3962564468383789,
-0.01711270585656166,
-0.14783617854118347,
-0.23446378111839294,
0.24494194984436035,
-0.060813818126916885,
-0.1329747438430786,
-0.19042722880840302,
-0.11165636777877808,
0.27383652329444885,
0.419262558221817,
0.2675628960132599,
0.1265554279088974,
0.10781139135360718,
0.09234596788883209,
-0.22297053039073944,
0.03716544806957245,
0.051937226206064224,
0.11972986906766891,
0.019041232764720917,
0.19035986065864563,
0.12361853569746017,
0.009703466668725014,
-0.20358923077583313,
-0.29502755403518677,
0.2105598896741867,
0.24119879305362701,
-0.061125148087739944,
-0.07158201187849045,
0.08872058242559433,
-0.2410697489976883,
0.009357101283967495,
0.12315070629119873,
-0.12003917992115021,
0.18404318392276764,
0.21190564334392548,
-0.010750049725174904,
0.0649929866194725,
-0.43688106536865234,
0.046440187841653824,
-0.21538779139518738,
-0.1295711100101471,
0.12238849699497223,
-0.016171209514141083,
0.11123940348625183,
-0.27860337495803833,
-0.06747731566429138,
-0.12464158236980438,
-0.32402706146240234,
0.0661180317401886,
0.06006040796637535,
-0.26499754190444946,
0.3846708834171295,
0.11385197937488556,
0.03339080139994621,
0.14102263748645782,
0.04943093657493591,
0.5404927730560303,
-0.13365335762500763,
-0.2698397934436798,
0.13433103263378143,
-0.012320617213845253,
0.1632768213748932,
-0.18154175579547882,
-0.2777721583843231,
-0.28715780377388,
-0.385410338640213,
0.17234298586845398,
0.06301610171794891,
0.04475461691617966,
-0.11989282816648483,
-0.07662750035524368,
0.0830358937382698,
0.41511520743370056,
0.16991327702999115,
0.07890451699495316,
0.2649683356285095,
-0.13961270451545715,
-0.001967149553820491,
-0.4640767574310303,
0.2252383679151535,
0.31227877736091614,
-0.04978427663445473,
-0.6084537506103516,
-0.014094509184360504,
-0.0016573395114392042,
0.33544883131980896,
-0.11551190912723541,
0.3176701068878174,
-0.025751255452632904,
0.10652091354131699,
0.20810936391353607,
0.18889901041984558,
-0.09731241315603256,
0.10145207494497299,
-0.18599244952201843,
-0.2652284502983093,
-0.1521749645471573,
0.38454610109329224,
-0.14695173501968384,
-0.11534468084573746,
-0.2760147750377655,
0.2931104898452759,
0.055396974086761475,
-0.12178093940019608,
-0.22134779393672943,
0.05455587059259415,
-0.044218890368938446,
-0.47330236434936523,
0.2649020850658417,
0.22925086319446564,
0.19664965569972992,
0.11616607755422592,
-0.2324564903974533,
-0.138968825340271,
-0.29436808824539185,
0.04085922986268997,
0.15850242972373962,
0.08376597613096237,
-0.15833637118339539,
-0.03283257782459259,
-0.3474678099155426,
-0.35130977630615234,
-0.07915378361940384,
0.04842869192361832,
-0.13610248267650604,
-0.30421024560928345,
0.21592049300670624,
-0.06482110917568207,
0.24513527750968933,
-0.377523273229599,
0.151401087641716,
-0.04444357752799988,
-0.3216678202152252,
0.25209489464759827,
0.15409697592258453,
0.05854921415448189,
-0.24653983116149902,
-0.14756040275096893,
0.11087904125452042,
-0.10555721819400787,
-0.4880673885345459,
-0.03875965625047684,
0.128426194190979,
-0.14861606061458588,
-0.12402782589197159,
0.2717393636703491,
-0.13028407096862793,
0.16526144742965698,
-0.07244080305099487,
0.25068360567092896,
-0.06042672321200371,
0.22150957584381104,
-0.08334753662347794,
0.022608201950788498,
-0.16350626945495605,
0.0015863338485360146,
0.02742942050099373,
0.2937883138656616,
-0.23148776590824127,
0.16539818048477173,
-0.0769340768456459,
0.18846555054187775,
0.16222001612186432,
0.2402781844139099,
0.3614705801010132,
-0.10689231753349304,
-0.23018205165863037,
-0.09075223654508591,
0.19328981637954712,
0.24607935547828674,
-0.2834280729293823,
-0.2114877998828888,
0.029640283435583115,
0.1443851888179779,
0.21206729114055634,
0.08565983921289444,
-0.06210639700293541,
0.04948041960597038,
-0.05196182429790497,
0.19573134183883667,
0.24054951965808868,
0.20595890283584595,
0.004832539241760969,
0.4493049681186676,
0.030350100249052048,
0.18197093904018402,
-0.013468078337609768,
-0.19358590245246887,
0.23791858553886414,
0.09410494565963745,
-0.10065848380327225,
0.09927085787057877,
0.009544474072754383,
0.15134133398532867,
0.2201225757598877,
-0.17134442925453186,
-0.044045280665159225,
-0.3031828999519348,
0.20693129301071167,
0.2547643184661865,
0.08225740492343903,
-0.2298210859298706,
0.08345755934715271,
-0.20513048768043518,
0.12174870818853378,
-0.3678702712059021,
0.12296818196773529,
-0.2111472189426422,
0.10371113568544388,
-0.06187549978494644,
-0.29020118713378906,
-0.2631121575832367,
-0.22604887187480927,
0.14097151160240173,
-0.28709179162979126,
-0.17903774976730347,
0.09501932561397552,
0.3698480427265167,
-0.18030063807964325,
0.1317560225725174,
-0.09847526252269745,
0.42195847630500793,
-0.2533474266529083,
-0.0018592007691040635,
0.10707442462444305,
0.31770023703575134,
-0.027255646884441376,
-0.07189241796731949,
0.28314146399497986,
0.35953208804130554,
0.024055056273937225,
-0.02388332597911358,
-0.3686550557613373,
-0.26272907853126526,
-0.010889885015785694,
-0.2004355937242508,
0.16392089426517487,
0.17201487720012665,
-0.15640407800674438,
-0.3782724142074585,
0.19839611649513245,
0.00931416917592287,
0.5364160537719727,
0.4658045172691345,
-0.4429595470428467,
-0.11198682337999344,
-0.13387541472911835,
0.136097714304924,
0.05005675181746483,
-0.038717564195394516,
0.0009655019384808838,
0.11799415200948715,
-0.20206338167190552,
-0.04966867342591286,
-0.14313986897468567,
0.429950475692749,
0.3401530385017395,
0.0007122303359210491,
0.056271180510520935,
0.35918548703193665,
-0.4867221415042877,
-0.24504318833351135,
0.035245075821876526,
-0.05160932242870331,
0.04988504946231842,
0.11414620280265808,
0.28667014837265015,
-0.329018771648407,
-0.08553503453731537,
-0.01903524063527584,
0.04354948177933693,
-0.00821284856647253,
-0.07295985519886017,
-0.24358125030994415,
-0.17352737486362457,
-0.14605195820331573,
0.2525003254413605,
-0.2258663773536682,
0.25471028685569763,
-0.004678789991885424,
0.05569189414381981,
-0.07897724956274033,
-0.19775386154651642,
-0.0997062474489212,
0.3016666769981384,
-0.001813271315768361,
-0.11026217043399811,
-0.02469319850206375,
0.14033038914203644,
-0.16079755127429962,
-0.04238860309123993,
0.1829572170972824,
0.03445561230182648,
-0.39870381355285645,
-0.04559751972556114,
-0.38523778319358826,
-0.06454459577798843,
-0.09747203439474106,
-0.06297431141138077,
-0.025452032685279846,
0.09224966168403625,
-0.043874867260456085,
-0.30278146266937256,
-0.1143849790096283,
0.17407500743865967,
0.13004042208194733,
-0.2599102854728699,
0.02654230408370495,
0.25008729100227356,
0.06221206486225128,
-0.2247050702571869,
-0.0396694578230381,
0.00993102416396141,
-0.05549882724881172,
0.3273238241672516,
0.09912338107824326,
0.11675938218832016,
0.15183039009571075,
0.19576844573020935,
-0.0903487429022789,
-0.09393934160470963,
0.09614748507738113,
-0.09769559651613235,
-0.33253830671310425,
0.00029431129223667085,
0.009914248250424862,
0.03531793877482414,
-0.039798326790332794,
0.36726582050323486,
0.22795842587947845,
0.052100323140621185
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA. Newborns with PA tested by expanded newborn screening have elevated C3 (propionylcarnitine). Testing of urine organic acids in persons who are symptomatic or those detected by newborn screening reveals elevated 3-hydroxypropionate and the presence of methylcitrate, tiglylglycine, propionylglycine, and lactic acid. Testing of plasma amino acids reveals elevated glycine. Confirmation of the diagnosis relies on detection of biallelic pathogenic variants in PCCA or PCCB or of deficient PCC enzymatic activity. In individuals with equivocal molecular genetic test results, a combination of enzymatic and molecular diagnostics may be necessary.Management.Treatment of manifestations: The treatment of individuals with acutely decompensated PA is a medical emergency: treat precipitating factors such as infection, dehydration, vomiting; reverse catabolism by providing intravenous glucose and lipids; manage protein intake to reduce propiogenic precursors; remove toxic compounds using nitrogen scavenger medications, extracorporeal detoxification, and/or | [
-0.1488860845565796,
0.06255938112735748,
-0.036066342145204544,
-0.2588646411895752,
0.23397967219352722,
0.1770518273115158,
0.02104114554822445,
-0.2980926036834717,
0.06318145990371704,
-0.15845204889774323,
0.25966882705688477,
0.1786305010318756,
-0.00909308809787035,
-0.060078591108322144,
-0.13912540674209595,
0.21633224189281464,
0.03109077736735344,
-0.03947143256664276,
-0.18466848134994507,
-0.12230320274829865,
0.22515298426151276,
-0.269095242023468,
-0.1078297346830368,
0.09015573561191559,
0.31581783294677734,
-0.1547761857509613,
0.2423677295446396,
-0.2819196283817291,
0.16842758655548096,
0.14442801475524902,
-0.10257581621408463,
0.018375858664512634,
0.13578177988529205,
-0.09875386953353882,
0.1128593310713768,
-0.11388709396123886,
-0.1569347381591797,
-0.4708745777606964,
0.015438211150467396,
-0.11610184609889984,
0.11814259737730026,
-0.11995425075292587,
0.26031941175460815,
-0.09752091765403748,
0.15364333987236023,
-0.230300635099411,
0.1168481633067131,
-0.19483092427253723,
-0.08240799605846405,
0.22528021037578583,
0.14456884562969208,
-0.22841104865074158,
-0.3852151334285736,
-0.0025566895492374897,
0.17058871686458588,
0.06766490638256073,
-0.13567623496055603,
-0.02610000967979431,
-0.22718992829322815,
0.29280978441238403,
0.09176073968410492,
-0.09869030117988586,
-0.08058420568704605,
-0.3278850317001343,
0.16104313731193542,
-0.16210930049419403,
0.11020418256521225,
0.22633621096611023,
0.20717836916446686,
0.1478199064731598,
0.12821458280086517,
0.03718843683600426,
0.014984830282628536,
0.08731752634048462,
-0.12030600011348724,
-0.15946751832962036,
0.111861452460289,
-0.03562029451131821,
0.006167202722281218,
-0.20134343206882477,
-0.1542726755142212,
0.13852518796920776,
-0.04915071278810501,
-0.07211675494909286,
-0.12809167802333832,
0.060605522245168686,
0.2229911834001541,
0.09946466982364655,
-0.26001885533332825,
-0.01793513633310795,
0.08097530901432037,
-0.05380166321992874,
0.26877301931381226,
0.04302186518907547,
0.020256854593753815,
-0.3519637882709503,
0.2661219537258148,
-0.007022729609161615,
-0.15347187221050262,
0.27948299050331116,
0.24653664231300354,
0.026967519894242287,
-0.20129118859767914,
-0.12420790642499924,
-0.2963159680366516,
-0.03937056288123131,
-0.16748455166816711,
-0.062047213315963745,
0.08220948278903961,
-0.13309019804000854,
0.17676059901714325,
-0.10820646584033966,
0.1418178379535675,
0.20313559472560883,
-0.5006088018417358,
0.024378564208745956,
-0.040905773639678955,
0.07961749285459518,
0.08431056886911392,
0.1505606472492218,
-0.10692091286182404,
0.016709119081497192,
0.06122148409485817,
0.25421419739723206,
0.0626901313662529,
0.18412601947784424,
0.0009839512640610337,
-0.16110876202583313,
0.4956520199775696,
-0.0685710534453392,
0.09464156627655029,
0.056615184992551804,
0.12242669612169266,
-0.166192889213562,
0.43885338306427,
0.1154421865940094,
-0.35579055547714233,
-0.22128857672214508,
0.013800105080008507,
0.17600299417972565,
0.30166009068489075,
0.2280346006155014,
0.3357735276222229,
0.28096169233322144,
0.29258230328559875,
0.04846596717834473,
0.10516901314258575,
-0.1684475690126419,
0.36662694811820984,
0.07084937393665314,
0.06430960446596146,
-0.6430148482322693,
-0.10295598208904266,
-0.1316603273153305,
-0.01707439124584198,
0.12001081556081772,
-0.11555784195661545,
0.19250176846981049,
-0.0009503625333309174,
-0.12284807860851288,
-0.028400542214512825,
0.02965271845459938,
-0.03404981270432472,
0.041296351701021194,
-0.035654641687870026,
0.189515620470047,
-0.3962826728820801,
0.03885020688176155,
0.11663888394832611,
0.013428499922156334,
-0.2010779082775116,
-0.012650599703192711,
-0.001767021487466991,
0.08083419501781464,
0.23134662210941315,
-0.20349976420402527,
0.07518809288740158,
-0.05645299702882767,
0.030768804252147675,
0.13835223019123077,
0.21520264446735382,
0.21515148878097534,
-0.1973317265510559,
-0.006103639490902424,
-0.13260836899280548,
-0.17764553427696228,
-0.09972250461578369,
-0.10395005345344543,
0.126163512468338,
0.021658020094037056,
0.01564096473157406,
-0.0056037274189293385,
0.02749190479516983,
0.09943027049303055,
0.16218817234039307,
-0.243790403008461,
0.16428636014461517,
0.02133592776954174,
0.10807386040687561,
-0.22866901755332947,
0.16708141565322876,
-0.30990365147590637,
0.04054652526974678,
-0.13785649836063385,
-0.14786136150360107,
0.06796631962060928,
0.05953329801559448,
-0.2894962728023529,
0.1558418720960617,
0.12172076851129532,
-0.2612304389476776,
0.23658917844295502,
-0.1761825531721115,
-0.021065881475806236,
-0.2671014666557312,
-0.06682728230953217,
0.07942665368318558,
-0.11897049844264984,
0.00921330600976944,
0.2653903067111969,
-0.08091697096824646,
-0.06212705746293068,
0.040084853768348694,
-0.36038538813591003,
-0.06010381877422333,
0.06969552487134933,
-0.3319844901561737,
-0.16992242634296417,
0.12800170481204987,
-0.1408146619796753,
-0.2883068919181824,
0.0013075564056634903,
0.029622694477438927,
0.28622549772262573,
-0.13873888552188873,
-0.3287731111049652,
-0.4325568974018097,
0.28314125537872314,
-0.16326738893985748,
-0.037736088037490845,
-0.2844613194465637,
-0.12659169733524323,
-0.14253513514995575,
0.07268976420164108,
0.11170286685228348,
0.07047951221466064,
0.02571096457540989,
-0.06488631665706635,
-0.21439503133296967,
0.0023176432587206364,
-0.14059120416641235,
0.23311303555965424,
-0.06084829568862915,
0.02612629532814026,
-0.21630027890205383,
-0.23924118280410767,
0.13958388566970825,
0.12108609825372696,
0.008894494734704494,
-0.07192277908325195,
-0.0048858392983675,
0.25534504652023315,
0.09921485930681229,
0.1708848923444748,
-0.09583037346601486,
-0.048238545656204224,
-0.3508155941963196,
-0.025376131758093834,
-0.21095986664295197,
-0.1120154857635498,
-0.01908358931541443,
0.3082505166530609,
0.4069349765777588,
0.03344205766916275,
-0.2605285346508026,
-0.2677736282348633,
0.1943253129720688,
0.03394847735762596,
-0.07016896456480026,
-0.14042522013187408,
-0.24866947531700134,
0.5645549893379211,
-0.07473556697368622,
0.07155555486679077,
0.30520543456077576,
0.16288067400455475,
-0.23723885416984558,
0.1302797943353653,
-0.016222497448325157,
0.18509137630462646,
0.12399102747440338,
0.2712137997150421,
-0.14170296490192413,
-0.19838257133960724,
0.21701769530773163,
0.11931915581226349,
-0.06738975644111633,
-0.04417463764548302,
0.06542696058750153,
0.2712372839450836,
0.08274231106042862,
0.0008041213732212782,
0.009511916898190975,
-0.3740803003311157,
-0.34022265672683716,
0.02920575998723507,
-0.15105338394641876,
-0.138383150100708,
0.2521634101867676,
0.08214730769395828,
-0.04528002068400383,
-0.1025211438536644,
-0.34233033657073975,
0.01989448443055153,
0.19048307836055756,
-0.1467236578464508,
0.26449012756347656,
0.0439399890601635,
-0.023745253682136536,
0.34596535563468933,
0.09677010029554367,
-0.014840886928141117,
-0.0427229069173336,
-0.00957478117197752,
-0.28060102462768555,
-0.12696436047554016,
-0.12581713497638702,
-0.007854041643440723,
-0.08530497550964355,
-0.0711284726858139,
0.2398918867111206,
0.31404396891593933,
-0.18046829104423523,
-0.1353297382593155,
0.4745153784751892,
0.02756032720208168,
0.43659085035324097,
0.17657841742038727,
0.019460119307041168,
0.04171425849199295,
0.16607581079006195,
-0.24293264746665955,
0.09473242610692978,
-0.19293126463890076,
-0.20441360771656036,
-0.021313464269042015,
0.09119517356157303,
0.25689932703971863,
0.04625474661588669,
-0.10806582123041153,
-0.13537822663784027,
0.13252459466457367,
0.12865076959133148,
-0.1484428197145462,
0.32343074679374695,
-0.13472343981266022,
0.012485567480325699,
0.16871634125709534,
0.1109967976808548,
-0.10670530796051025,
-0.2367744892835617,
0.010392233729362488,
0.1548289954662323,
-0.023143278434872627,
-0.06237861141562462,
-0.12617141008377075,
0.07842469960451126,
0.19046853482723236,
0.19343987107276917,
0.14420978724956512,
0.022374821826815605,
0.0731235146522522,
0.18051420152187347,
0.09947885572910309,
-0.10517852008342743,
0.05063362047076225,
-0.17558568716049194,
-0.005496087949723005,
-0.1009954959154129,
-0.04536692425608635,
-0.06767114996910095,
0.00001912424704642035,
0.005800300743430853,
0.19026581943035126,
-0.09523648768663406,
0.03234032541513443,
0.12592053413391113,
0.2777624726295471,
0.17901727557182312,
-0.47997933626174927,
0.06324391812086105,
0.17258583009243011,
0.2031339555978775,
0.25966301560401917,
-0.004882002715021372,
0.10891487449407578,
0.04310093820095062,
-0.005435282830148935,
-0.2103850394487381,
0.27200832962989807,
0.007011814508587122,
0.042528845369815826,
0.21796809136867523,
0.10501933842897415,
-0.07856721431016922,
0.16291098296642303,
0.04582992196083069,
0.13413205742835999,
0.049264539033174515,
-0.02698856219649315,
-0.06683900952339172,
0.14641708135604858,
-0.035007596015930176,
-0.04985039681196213,
0.04851895570755005,
-0.24009597301483154,
-0.29111507534980774,
0.23859649896621704,
0.1831740140914917,
-0.031467411667108536,
-0.0711255893111229,
0.2858606278896332,
0.16218389570713043,
0.021901022642850876,
-0.19371691346168518,
-0.05060772970318794,
-0.01302054338157177,
-0.03360820189118385,
0.09026385098695755,
0.11412318050861359,
0.34390789270401,
0.013748984783887863,
-0.044049885123968124,
-0.02826582081615925,
0.02132382243871689,
0.03371535614132881,
-0.2996598482131958,
0.030286937952041626,
-0.14000484347343445,
-0.12246081978082657,
0.2529596984386444,
-0.10065298527479172,
-0.24759210646152496,
-0.06673119217157364,
-0.11381202936172485,
0.22045493125915527,
0.3586943745613098,
0.2913525402545929,
0.06876784563064575,
0.012833228334784508,
0.026916684582829475,
0.009993655607104301,
0.049825139343738556,
0.06876007467508316,
0.17283816635608673,
-0.041437286883592606,
0.13681744039058685,
0.1471632570028305,
0.00006189467967487872,
-0.1647345870733261,
-0.1947135627269745,
0.16929829120635986,
0.22278372943401337,
-0.17179062962532043,
-0.16100448369979858,
0.1650678813457489,
-0.19982308149337769,
0.02691113017499447,
-0.0014893892221152782,
-0.20424072444438934,
0.1286487579345703,
0.08783872425556183,
-0.08931489288806915,
-0.06817369908094406,
-0.24867838621139526,
0.10933475941419601,
-0.06540005654096603,
-0.12737712264060974,
0.16353818774223328,
0.16659308969974518,
0.04587928578257561,
-0.32226213812828064,
-0.06015545502305031,
-0.17146357893943787,
-0.17974813282489777,
0.11378804594278336,
0.021883215755224228,
-0.13696908950805664,
0.3460269570350647,
0.022043073549866676,
0.08112769573926926,
0.2609006464481354,
0.09425898641347885,
0.5064290761947632,
-0.049361955374479294,
-0.179427832365036,
0.0826580822467804,
-0.05321589484810829,
0.019651681184768677,
-0.044731199741363525,
-0.2253747582435608,
-0.18640659749507904,
-0.2787502706050873,
0.16917391121387482,
-0.07128719240427017,
0.10632798820734024,
-0.08318357914686203,
-0.11752485483884811,
0.05185272917151451,
0.3244151473045349,
0.02890634350478649,
0.1379069983959198,
0.0004387868975754827,
-0.06022033467888832,
-0.03872305899858475,
-0.3010731637477875,
0.1348743885755539,
0.346110999584198,
-0.016087301075458527,
-0.4136086404323578,
-0.008862689137458801,
-0.13540273904800415,
0.1518222540616989,
-0.059168700128793716,
0.22667138278484344,
-0.006238729227334261,
0.02188311703503132,
0.08079387992620468,
0.08609816431999207,
-0.04460021108388901,
0.05089394375681877,
-0.1369306594133377,
-0.11106570065021515,
-0.07700684666633606,
0.30082738399505615,
0.007731068879365921,
-0.16470974683761597,
-0.16880470514297485,
0.17244286835193634,
-0.09794606268405914,
-0.019407104700803757,
-0.3383544981479645,
0.08421902358531952,
-0.07951761037111282,
-0.5268396735191345,
0.4408896565437317,
0.2574426531791687,
0.08758681267499924,
0.10144251585006714,
-0.1711568385362625,
-0.17416676878929138,
-0.32955342531204224,
0.05157511681318283,
0.026993459090590477,
0.04081285744905472,
-0.13637225329875946,
0.04146355018019676,
-0.38911598920822144,
-0.18566134572029114,
-0.03895622491836548,
-0.012643445283174515,
-0.10310395807027817,
-0.2362855076789856,
0.17809349298477173,
-0.06772404164075851,
0.11480845510959625,
-0.3310764729976654,
0.007079945877194405,
-0.11646772176027298,
-0.3388427495956421,
0.0782998725771904,
0.095166876912117,
-0.08222797513008118,
-0.2933995723724365,
-0.09938620030879974,
0.11369950324296951,
-0.13522157073020935,
-0.38855046033859253,
-0.17962943017482758,
0.052963998168706894,
-0.12967683374881744,
-0.22910866141319275,
0.18256889283657074,
0.034793660044670105,
0.01932390406727791,
-0.12109337002038956,
0.14906924962997437,
0.057284846901893616,
0.23616553843021393,
-0.1077321395277977,
0.08397619426250458,
-0.18822400271892548,
0.027405807748436928,
0.033447545021772385,
0.11203458160161972,
-0.1795158088207245,
0.1890484243631363,
0.11265680938959122,
0.23602591454982758,
0.14376488327980042,
0.3137308359146118,
0.1505192071199417,
-0.11665420234203339,
-0.24741700291633606,
-0.24354442954063416,
0.15933749079704285,
0.26826992630958557,
-0.2194007784128189,
-0.1275646686553955,
-0.006159801036119461,
0.012078441679477692,
-0.019075937569141388,
0.029437504708766937,
0.03561422973871231,
0.1312742382287979,
0.003758284728974104,
0.10093939304351807,
0.02916794642806053,
0.129277765750885,
-0.019388984888792038,
0.4006080627441406,
-0.06865942478179932,
0.2031157910823822,
0.05232246220111847,
-0.14242728054523468,
0.11250621825456619,
0.09222530573606491,
-0.2447386234998703,
0.12379763275384903,
-0.07327622175216675,
0.3835931420326233,
0.20917025208473206,
-0.11389058083295822,
0.054005883634090424,
-0.18563640117645264,
0.042503878474235535,
0.09805761277675629,
-0.15536755323410034,
-0.25520431995391846,
0.1824447512626648,
-0.040087491273880005,
0.06860654801130295,
-0.1910800337791443,
0.15208278596401215,
-0.34183943271636963,
0.040215156972408295,
-0.10357392579317093,
-0.23787318170070648,
-0.06476864963769913,
-0.3103683888912201,
0.08849675208330154,
-0.1652774065732956,
0.005919217597693205,
0.037431661039590836,
0.3836442828178406,
-0.23664353787899017,
0.29326048493385315,
-0.2980894446372986,
0.2594125270843506,
-0.34638500213623047,
0.01672029122710228,
-0.040220070630311966,
0.22916272282600403,
-0.07092083245515823,
0.005743475165218115,
0.24743634462356567,
0.31029191613197327,
-0.04026045277714729,
0.07356332242488861,
-0.29154515266418457,
-0.3119531571865082,
-0.09902586787939072,
-0.08100946992635727,
0.08340910822153091,
0.2936299443244934,
-0.11145241558551788,
-0.19536474347114563,
0.2967115640640259,
-0.014220241457223892,
0.4959569573402405,
0.3351895809173584,
-0.388165682554245,
-0.33611783385276794,
-0.04463455080986023,
-0.010329361073672771,
0.08533766120672226,
0.0656355544924736,
-0.007288893684744835,
0.16529174149036407,
-0.18023693561553955,
-0.005929603707045317,
-0.14992982149124146,
0.35974615812301636,
0.17931286990642548,
0.05531104654073715,
0.12361247092485428,
0.3893764019012451,
-0.23833175003528595,
-0.1750461906194687,
-0.08820070326328278,
-0.015461900271475315,
0.12286891788244247,
0.004377332516014576,
0.2942599952220917,
-0.2508607506752014,
-0.0738312229514122,
0.08336852490901947,
0.02018554136157036,
0.03592408075928688,
-0.2844385504722595,
-0.2865806221961975,
-0.18419377505779266,
-0.16706374287605286,
0.28316760063171387,
-0.32686126232147217,
0.21614854037761688,
-0.06592930108308792,
0.05244576930999756,
-0.010481744073331356,
-0.20582856237888336,
0.013605080544948578,
0.19508741796016693,
-0.022058378905057907,
-0.08477500826120377,
0.09936424344778061,
0.18019790947437286,
-0.15585075318813324,
0.06446507573127747,
0.11603840440511703,
0.08459848910570145,
-0.3432799279689789,
-0.06641598790884018,
-0.4998916983604431,
-0.15432587265968323,
-0.07181370258331299,
-0.11972804367542267,
-0.12421901524066925,
-0.08001064509153366,
-0.15640893578529358,
-0.29394277930259705,
-0.03648039698600769,
0.1874397248029709,
0.1795514076948166,
-0.2053993046283722,
0.08917281031608582,
0.2949073314666748,
0.13667714595794678,
-0.22229145467281342,
-0.08018910139799118,
-0.08341855555772781,
0.06105509772896767,
0.38661468029022217,
-0.13241593539714813,
0.059152282774448395,
0.09129314124584198,
0.12759308516979218,
-0.06112869083881378,
-0.04260046407580376,
0.06602025032043457,
-0.20037014782428741,
-0.21740494668483734,
-0.10209271311759949,
0.015771029517054558,
0.07409941405057907,
0.0702330693602562,
0.24244099855422974,
0.2530454099178314,
-0.000771236780565232
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. allelic pathogenic variants in PCCA or PCCB or of deficient PCC enzymatic activity. In individuals with equivocal molecular genetic test results, a combination of enzymatic and molecular diagnostics may be necessary.Management.Treatment of manifestations: The treatment of individuals with acutely decompensated PA is a medical emergency: treat precipitating factors such as infection, dehydration, vomiting; reverse catabolism by providing intravenous glucose and lipids; manage protein intake to reduce propiogenic precursors; remove toxic compounds using nitrogen scavenger medications, extracorporeal detoxification, and/or intravenous carnitine; transfer to a center with biochemical genetics expertise and the ability to support urgent hemodialysis, especially if hyperammonemia is present.Prevention of primary manifestations: Individualized dietary management should be directed by an experienced physician and metabolic dietician to control the intake of propiogenic substrates and to guide increased caloric intake during illness to prevent catabolism. G-tube placement is an effective strategy to facilitate the administration of medications and nutrition during acute decompensations and to improve adherence in chronic management | [
-0.19488772749900818,
0.08090103417634964,
-0.10463497787714005,
-0.2842463254928589,
0.04021558165550232,
0.04517009109258652,
0.14914336800575256,
-0.2766827940940857,
-0.03222862258553505,
-0.1668553501367569,
0.25771456956863403,
-0.006703495979309082,
0.05093371123075485,
0.10984478145837784,
-0.2991355061531067,
0.05277743563055992,
-0.03416121006011963,
-0.047944311052560806,
-0.0028437096625566483,
0.1133643314242363,
0.25390130281448364,
-0.21095076203346252,
0.02404712699353695,
0.0853370800614357,
0.3084486126899719,
-0.025939960032701492,
0.2603885531425476,
-0.4226115643978119,
0.07309363037347794,
0.06951356679201126,
-0.015000510029494762,
0.00336738140322268,
0.03225003555417061,
-0.21653670072555542,
-0.07342781871557236,
-0.24157831072807312,
-0.03197420388460159,
-0.2188149243593216,
0.07071782648563385,
-0.12076626718044281,
0.02347886748611927,
-0.12472041696310043,
0.4044799208641052,
0.019118094816803932,
0.17764393985271454,
-0.08184783905744553,
0.07364024221897125,
-0.16045619547367096,
-0.03444249927997589,
0.2688784599304199,
0.09349831938743591,
-0.1326393336057663,
-0.2805567681789398,
-0.2129947692155838,
0.36911138892173767,
-0.2721423804759979,
-0.04234424978494644,
0.092573381960392,
-0.20454896986484528,
0.03239542990922928,
0.054838184267282486,
-0.32375723123550415,
-0.0030057309195399284,
-0.32555097341537476,
0.20788154006004333,
-0.08011958003044128,
-0.11368286609649658,
0.045214686542749405,
0.2817247211933136,
-0.14945369958877563,
0.04666810482740402,
-0.04603615775704384,
-0.044276390224695206,
0.1317504197359085,
-0.00033325402182526886,
-0.00780228478834033,
0.1173442080616951,
-0.005305962171405554,
-0.08647582679986954,
-0.4025895893573761,
-0.19277575612068176,
0.03055531159043312,
-0.03977157175540924,
-0.14458496868610382,
-0.13540084660053253,
0.014887494966387749,
0.24825264513492584,
0.06057228893041611,
-0.04401417821645737,
0.08016826212406158,
0.04918990284204483,
-0.033386122435331345,
-0.07408865541219711,
0.14675258100032806,
0.012238072231411934,
-0.2206261157989502,
0.11407636106014252,
-0.13037176430225372,
-0.0972592905163765,
0.12803198397159576,
0.0589975081384182,
-0.1233995258808136,
-0.10002954304218292,
-0.034090787172317505,
0.012449434958398342,
0.02400030381977558,
-0.22996455430984497,
-0.019437987357378006,
-0.007157802116125822,
0.06098422780632973,
0.2303946316242218,
-0.15300804376602173,
0.28160810470581055,
0.019890060648322105,
-0.3968667984008789,
-0.19137613475322723,
-0.028011931106448174,
0.25361761450767517,
0.13212189078330994,
-0.02285192906856537,
-0.023833217099308968,
0.23977895081043243,
0.15555928647518158,
-0.10081075131893158,
-0.058591850101947784,
-0.0198283102363348,
0.1076882928609848,
-0.07204825431108475,
0.1890120953321457,
-0.16555571556091309,
-0.018348775804042816,
0.09422069042921066,
0.10329793393611908,
-0.05047101154923439,
0.15118256211280823,
-0.15673503279685974,
-0.26208847761154175,
-0.3078790009021759,
-0.014539159834384918,
0.058035191148519516,
0.27402588725090027,
0.35311445593833923,
0.10749318450689316,
0.06860102713108063,
0.009754546917974949,
0.113156758248806,
0.3263894319534302,
-0.009492556564509869,
-0.00036553331301547587,
-0.0397011898458004,
-0.05218429118394852,
-0.35135626792907715,
0.006490468978881836,
0.020224742591381073,
-0.012093331664800644,
0.13696272671222687,
0.08518116921186447,
0.2804410755634308,
-0.2293228954076767,
-0.09152316302061081,
0.021582137793302536,
-0.04438989609479904,
0.10137747973203659,
0.15309984982013702,
-0.036805130541324615,
0.13832996785640717,
-0.209711492061615,
0.16358289122581482,
0.001411894802004099,
-0.18785303831100464,
-0.02152707614004612,
0.014969182200729847,
0.09792076051235199,
0.11242137849330902,
-0.07240429520606995,
0.0492597296833992,
-0.10341843962669373,
-0.09697165340185165,
-0.04559742286801338,
0.1439826339483261,
0.23942744731903076,
-0.124585822224617,
-0.11350803822278976,
0.017401255667209625,
-0.12588371336460114,
-0.15407785773277283,
0.2616164982318878,
0.08923672884702682,
0.11318089067935944,
0.24071544408798218,
0.3371027410030365,
-0.0312771275639534,
-0.1304125338792801,
0.06549887359142303,
0.10200820118188858,
-0.16011954843997955,
0.2160470187664032,
0.10449625551700592,
0.01674850471317768,
-0.17513149976730347,
-0.14073807001113892,
-0.240518257021904,
0.0011111859930679202,
-0.06323051452636719,
-0.14351008832454681,
-0.038956645876169205,
0.07451244443655014,
-0.25450149178504944,
0.051254212856292725,
-0.09156277775764465,
-0.206852987408638,
0.1023283377289772,
-0.13784456253051758,
0.02516099065542221,
-0.3368454575538635,
-0.02498745545744896,
0.1261100023984909,
-0.192361518740654,
-0.04239649698138237,
0.18268397450447083,
-0.19437173008918762,
0.0035364138893783092,
0.09920132160186768,
-0.1906309723854065,
-0.2146894782781601,
-0.02829977497458458,
-0.3203401267528534,
-0.11195455491542816,
0.01939857378602028,
-0.21355867385864258,
-0.06939905136823654,
0.024532461538910866,
0.022231118753552437,
0.14273755252361298,
-0.23612681031227112,
0.007600272540003061,
-0.16202020645141602,
0.34665706753730774,
-0.11704361438751221,
-0.02191305160522461,
-0.3985833525657654,
0.045910291373729706,
-0.02773546241223812,
-0.035087596625089645,
0.019463323056697845,
0.18801665306091309,
-0.0305530596524477,
0.06172953173518181,
-0.06260592490434647,
-0.01455184817314148,
-0.016206199303269386,
0.06381344795227051,
0.05145709589123726,
0.03954670578241348,
-0.29358282685279846,
-0.1081165000796318,
0.07128655910491943,
-0.17226362228393555,
-0.04054053872823715,
0.043670330196619034,
-0.2909640073776245,
-0.0064964150078594685,
0.10900352895259857,
0.07684946805238724,
-0.02462817169725895,
-0.07403060793876648,
-0.24988721311092377,
0.0013393729459494352,
-0.06107475236058235,
-0.19575780630111694,
-0.07324723899364471,
0.15529559552669525,
0.18268044292926788,
0.03705352172255516,
-0.2857694923877716,
-0.22906818985939026,
0.13311776518821716,
0.179373100399971,
0.1974649727344513,
-0.18363621830940247,
-0.13590815663337708,
0.229563906788826,
0.1593075543642044,
-0.062022678554058075,
0.0999019593000412,
-0.02839188650250435,
-0.019564257934689522,
0.0921701043844223,
0.009383506141602993,
0.06661640107631683,
0.07255620509386063,
-0.01444882433861494,
0.009188132360577583,
-0.07368529587984085,
0.24798166751861572,
0.17876051366329193,
-0.044234976172447205,
0.12002701312303543,
0.10018263757228851,
0.07328936457633972,
0.05398383364081383,
0.07765450328588486,
0.10784383118152618,
-0.22077298164367676,
-0.19931066036224365,
-0.0125409672036767,
-0.07964932173490524,
-0.01215442456305027,
0.32492566108703613,
0.3442246615886688,
-0.010340179316699505,
-0.1765947788953781,
-0.36010098457336426,
0.04348946735262871,
-0.08529186248779297,
-0.01192186214029789,
-0.07482591271400452,
0.20870117843151093,
0.08570978790521622,
0.04714735224843025,
-0.07231703400611877,
0.05685707554221153,
0.0005569309578277171,
0.0046521141193807125,
-0.2616008520126343,
-0.14105574786663055,
-0.017702383920550346,
-0.05290447920560837,
-0.051426179707050323,
0.1632567048072815,
-0.150902658700943,
0.1046566516160965,
-0.05633912608027458,
-0.10055863857269287,
0.32505127787590027,
-0.20114022493362427,
0.18142399191856384,
-0.027288183569908142,
-0.09404630213975906,
-0.030037229880690575,
0.10117798298597336,
-0.3368075489997864,
0.017695574089884758,
-0.11379490047693253,
-0.11194207519292831,
0.002134827198460698,
-0.031098220497369766,
-0.0031726467423141003,
0.14548762142658234,
-0.09394032508134842,
-0.08185309171676636,
0.022906837984919548,
-0.028515158221125603,
-0.2344273328781128,
0.18160487711429596,
-0.1696881204843521,
-0.09310925751924515,
0.15907829999923706,
0.04485129192471504,
0.17278563976287842,
-0.2587207555770874,
-0.07909463346004486,
0.24412646889686584,
-0.10584638267755508,
-0.03188551589846611,
-0.06104789674282074,
0.0319986417889595,
-0.050156958401203156,
0.29520949721336365,
-0.02799047715961933,
0.13086627423763275,
0.2185598462820053,
0.04693293944001198,
0.06161629408597946,
0.03228716552257538,
0.12413135170936584,
0.0626513659954071,
0.041997700929641724,
-0.20190618932247162,
-0.17487342655658722,
0.14009976387023926,
-0.03432174772024155,
0.09124063700437546,
0.013313189148902893,
0.036627285182476044,
-0.02569040283560753,
-0.06649857014417648,
0.24048715829849243,
0.10859090089797974,
-0.5371516942977905,
0.02699068747460842,
0.15958012640476227,
0.12307242304086685,
0.1185578778386116,
0.11070705950260162,
0.23032210767269135,
0.024397211149334908,
0.15327396988868713,
-0.0783088281750679,
0.1354503333568573,
-0.09428541362285614,
-0.1506316214799881,
0.15922172367572784,
0.3049120008945465,
0.06512497365474701,
-0.126653254032135,
-0.04237564280629158,
0.223122701048851,
0.01366138644516468,
0.007398902904242277,
-0.10851854085922241,
-0.05468780919909477,
0.01537384744733572,
-0.11471003293991089,
0.054411422461271286,
-0.0797213762998581,
-0.24979649484157562,
0.09746573120355606,
-0.028201736509799957,
0.005801387596875429,
0.02491205930709839,
0.10783630609512329,
0.03351091966032982,
-0.24360741674900055,
-0.21032573282718658,
0.1760515570640564,
0.06547699123620987,
-0.02835269644856453,
0.17340214550495148,
0.12763142585754395,
0.29997730255126953,
0.11912579089403152,
-0.1474863588809967,
-0.04260355234146118,
-0.039351917803287506,
0.02732802741229534,
-0.2371036261320114,
0.07571087032556534,
0.02778054215013981,
-0.12101897597312927,
0.09933040291070938,
0.015350935980677605,
-0.10320162773132324,
0.07452595233917236,
-0.07972965389490128,
-0.007453455589711666,
0.1305389702320099,
0.3126533031463623,
0.07834041863679886,
0.14724622666835785,
0.10916968435049057,
-0.04681357741355896,
-0.1415673941373825,
0.01750274747610092,
0.14842842519283295,
-0.013715065084397793,
0.02751288004219532,
0.02210870198905468,
0.11763753741979599,
-0.047013524919748306,
-0.05723341554403305,
0.21173745393753052,
0.21219110488891602,
-0.017240408807992935,
-0.2664780616760254,
-0.11701208353042603,
-0.16763968765735626,
0.037447452545166016,
0.10358759760856628,
0.007766624912619591,
0.15985162556171417,
0.02301749773323536,
-0.07922980934381485,
0.11499564349651337,
-0.019245769828557968,
0.06751557439565659,
0.09321152418851852,
-0.08886565268039703,
-0.032453395426273346,
0.211675763130188,
-0.014860894531011581,
-0.2967349588871002,
-0.08717349171638489,
-0.11891689151525497,
-0.1866006702184677,
0.13774161040782928,
-0.16148443520069122,
-0.0022165097761899233,
0.30540427565574646,
-0.10538199543952942,
0.011807290837168694,
0.0007114983163774014,
-0.17510464787483215,
0.32329437136650085,
-0.17872324585914612,
-0.1609720140695572,
0.01991252973675728,
-0.12472136318683624,
-0.04899273067712784,
-0.05051131919026375,
-0.03760519623756409,
0.008036751300096512,
-0.16740782558918,
0.1300322264432907,
-0.05317629873752594,
0.013756318017840385,
0.011019539088010788,
-0.16967983543872833,
0.09277980774641037,
0.29456594586372375,
-0.09337703138589859,
0.1640964299440384,
-0.1364744007587433,
0.12429164350032806,
-0.0010428458917886019,
-0.3388567268848419,
-0.0006326012662611902,
0.2435687780380249,
-0.01512521505355835,
-0.020018473267555237,
0.1701997071504593,
0.057775769382715225,
0.08090846240520477,
-0.033264271914958954,
0.11014224588871002,
-0.04360830783843994,
0.004769915249198675,
0.17367345094680786,
-0.057763826102018356,
-0.03823888301849365,
0.11194612830877304,
-0.09962006658315659,
0.01820334419608116,
-0.036595530807971954,
0.11706763505935669,
0.08848892152309418,
-0.05095305293798447,
-0.07464288175106049,
-0.15752266347408295,
-0.1682536005973816,
0.14741453528404236,
-0.058228399604558945,
0.007400472182780504,
0.10262701660394669,
-0.2787984609603882,
0.19618003070354462,
0.09191667288541794,
0.10535593330860138,
0.1554398089647293,
-0.0042660413309931755,
-0.10035625100135803,
-0.1368923783302307,
-0.013349367305636406,
0.05377931892871857,
-0.0023680527228862047,
-0.09650073200464249,
-0.11753947287797928,
0.00563293369486928,
-0.14715877175331116,
0.04161826893687248,
-0.0912400633096695,
-0.08651549369096756,
-0.1991305947303772,
0.01374620571732521,
-0.14322026073932648,
0.12703365087509155,
-0.04539068788290024,
-0.3656054437160492,
0.08744596689939499,
-0.221065491437912,
0.043999090790748596,
0.09150778502225876,
0.087724469602108,
-0.14178581535816193,
-0.12100445479154587,
0.10724182426929474,
-0.15393245220184326,
-0.33777374029159546,
-0.271879643201828,
0.09194355458021164,
-0.09574001282453537,
-0.25038835406303406,
0.06531766802072525,
0.0007306692423298955,
0.15616276860237122,
-0.0930337980389595,
-0.062826968729496,
0.10718639194965363,
0.21577076613903046,
0.031802479177713394,
-0.020760763436555862,
-0.0765591412782669,
-0.020030906423926353,
-0.040249235928058624,
0.06009708344936371,
-0.3107934296131134,
0.3221271336078644,
-0.31823909282684326,
0.016098426654934883,
0.07857058197259903,
0.08126810193061829,
0.1131923496723175,
-0.08576955646276474,
-0.21297407150268555,
-0.015563694760203362,
-0.21604380011558533,
0.12116525322198868,
-0.2737181782722473,
-0.2657163441181183,
0.04556811600923538,
0.06245001405477524,
0.043060485273599625,
0.06503526866436005,
-0.008726385422050953,
-0.08568724244832993,
0.06754645705223083,
0.3085375130176544,
-0.06508851796388626,
0.05525488033890724,
0.06309077143669128,
0.3496040403842926,
-0.050475817173719406,
0.1733359545469284,
-0.028103116899728775,
-0.12123625725507736,
0.08177495002746582,
-0.126910001039505,
0.031167397275567055,
0.02589869685471058,
-0.06836871057748795,
0.15964236855506897,
0.2638089656829834,
0.056408897042274475,
-0.038444872945547104,
-0.020587338134646416,
-0.011960464529693127,
0.09523025900125504,
-0.06881451606750488,
-0.2763218879699707,
0.19745777547359467,
-0.1308189332485199,
0.12251847237348557,
0.05897277221083641,
0.15705247223377228,
-0.28281763195991516,
0.043468739837408066,
-0.15871666371822357,
-0.044169310480356216,
-0.0072266352362930775,
-0.17041310667991638,
-0.0770767405629158,
0.07400909811258316,
0.042104944586753845,
0.1333535760641098,
0.3789843022823334,
-0.14816798269748688,
0.23729351162910461,
-0.09198979288339615,
0.1524202525615692,
-0.04082614555954933,
0.026641402393579483,
0.01903661899268627,
-0.016876740381121635,
-0.05048707500100136,
0.005053785163909197,
0.0899762436747551,
0.08463870733976364,
-0.08845704048871994,
0.11049488931894302,
-0.17947930097579956,
-0.12544246017932892,
-0.01929149590432644,
0.07469604909420013,
0.05754517391324043,
-0.02501629665493965,
0.15656700730323792,
0.036984171718358994,
0.17588840425014496,
-0.1687636822462082,
0.1783968210220337,
0.13476547598838806,
-0.27411767840385437,
-0.2810724675655365,
-0.03617116063833237,
0.13218802213668823,
-0.005522868596017361,
0.10391809046268463,
-0.05168498679995537,
0.09052402526140213,
-0.21588116884231567,
0.08904018998146057,
-0.18126188218593597,
0.19915366172790527,
0.06155554577708244,
-0.04606093466281891,
0.15599532425403595,
0.36339226365089417,
-0.14384689927101135,
-0.2220108062028885,
-0.22798623144626617,
-0.06812917441129684,
-0.1012386903166771,
-0.00869668461382389,
0.18757003545761108,
-0.06640475988388062,
-0.16151459515094757,
0.20182162523269653,
-0.09032760560512543,
0.1644948422908783,
-0.1736370027065277,
-0.19556309282779694,
-0.09281348437070847,
-0.1790114790201187,
0.006527968682348728,
-0.21315699815750122,
0.04240984469652176,
-0.08893860876560211,
0.2427969127893448,
-0.021973395720124245,
0.008263642899692059,
-0.032714247703552246,
0.06163246929645538,
-0.0450199730694294,
-0.19626043736934662,
0.16789688169956207,
-0.015794914215803146,
-0.07286085188388824,
0.1679571270942688,
0.11901070177555084,
-0.11689069122076035,
-0.10003306716680527,
-0.0997033640742302,
-0.2998783588409424,
-0.08070747554302216,
-0.0880877897143364,
0.1293768435716629,
-0.04167146608233452,
-0.15339845418930054,
0.06568973511457443,
-0.054485518485307693,
-0.017114603891968727,
0.007914898917078972,
0.026999449357390404,
-0.1367877870798111,
0.06253525614738464,
0.1034533828496933,
0.0611017644405365,
-0.04126519709825516,
-0.14620187878608704,
-0.034452181309461594,
0.08242432773113251,
0.10908341407775879,
-0.031207609921693802,
0.053323887288570404,
-0.013868998736143112,
-0.044822465628385544,
-0.060867637395858765,
-0.1750647872686386,
0.109471894800663,
-0.019231010228395462,
-0.17943823337554932,
-0.1115502119064331,
-0.06410012394189835,
0.0883558914065361,
0.011397144757211208,
0.2382906824350357,
0.07873855531215668,
0.17530886828899384
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. extracorporeal detoxification, and/or intravenous carnitine; transfer to a center with biochemical genetics expertise and the ability to support urgent hemodialysis, especially if hyperammonemia is present.Prevention of primary manifestations: Individualized dietary management should be directed by an experienced physician and metabolic dietician to control the intake of propiogenic substrates and to guide increased caloric intake during illness to prevent catabolism. G-tube placement is an effective strategy to facilitate the administration of medications and nutrition during acute decompensations and to improve adherence in chronic management of PA.Medications may include: L-carnitine supplementation to enhance excretion of propionic acid and oral metronidazole to reduce propionate production by gut bacteria. Orthotopic liver transplantation (OLT) may be indicated in those with frequent metabolic decompensations, uncontrollable hyperammonemia, and/or poor growth.Prevention of secondary complications: Consistent evaluation of the protein intake, depending on age, gender, severity of disorder and presence of other factors such as intercurrent illness, surgery, level of | [
-0.10085143148899078,
-0.07269317656755447,
-0.10677383095026016,
-0.2452477663755417,
0.1300584077835083,
0.1287137269973755,
0.0839872807264328,
-0.26606684923171997,
-0.15305636823177338,
-0.06295877695083618,
0.26496437191963196,
-0.014087174087762833,
-0.131927952170372,
0.06758741289377213,
-0.3393722474575043,
0.12823761999607086,
-0.0472346767783165,
0.04598953574895859,
-0.12589031457901,
0.10802311450242996,
0.267037957906723,
-0.17090992629528046,
0.08214151114225388,
0.1035156399011612,
0.31304532289505005,
-0.09269166737794876,
0.3491297960281372,
-0.2355262190103531,
0.14884847402572632,
0.08373620361089706,
0.06305427104234695,
-0.09476165473461151,
0.006787525024265051,
-0.14318348467350006,
-0.08702857047319412,
-0.1457904577255249,
-0.03695644065737724,
-0.31486281752586365,
-0.03704623505473137,
-0.23009322583675385,
0.006840296555310488,
-0.14509283006191254,
0.29754796624183655,
-0.12015672028064728,
0.3442656397819519,
-0.14193476736545563,
0.04988481104373932,
-0.16335105895996094,
-0.09266869723796844,
0.195079505443573,
0.0329330712556839,
-0.1572328358888626,
-0.04906046390533447,
-0.03308629244565964,
0.3639664053916931,
-0.3202107548713684,
0.006739336531609297,
0.08549626916646957,
-0.10451507568359375,
-0.03377371281385422,
-0.004257401451468468,
-0.4450133442878723,
-0.09296499937772751,
-0.2104651778936386,
0.2850320041179657,
0.013704007491469383,
-0.135233536362648,
0.024276459589600563,
0.43887487053871155,
-0.12092015892267227,
0.1156419962644577,
0.12575572729110718,
-0.18163751065731049,
0.08595207333564758,
-0.08872749656438828,
-0.09992068260908127,
0.10164505988359451,
0.08159679174423218,
0.03517156466841698,
-0.18204067647457123,
-0.20067109167575836,
0.05767493695020676,
-0.0835629552602768,
-0.12165322154760361,
-0.0030396224465221167,
0.1412598043680191,
0.2121996134519577,
0.0847359299659729,
-0.06930118799209595,
0.11390117555856705,
-0.004223826806992292,
-0.09789692610502243,
-0.060846440494060516,
0.03288174793124199,
0.10386916249990463,
-0.22909876704216003,
0.1527414172887802,
-0.3400244414806366,
-0.13687090575695038,
0.16926448047161102,
0.08420906960964203,
-0.08125928789377213,
-0.08282532542943954,
-0.08661177009344101,
-0.06630873680114746,
-0.004129094537347555,
-0.14122408628463745,
0.11583505570888519,
0.04619455337524414,
0.06765025854110718,
0.24659237265586853,
-0.210427388548851,
0.3272649347782135,
0.07363978773355484,
-0.5081621408462524,
-0.16514991223812103,
-0.07170885801315308,
0.24459174275398254,
0.12979938089847565,
-0.027952784672379494,
-0.10867264866828918,
0.07969997823238373,
0.11723484843969345,
0.011622154153883457,
-0.009483987465500832,
0.18718872964382172,
-0.025401925668120384,
-0.22828859090805054,
0.21962177753448486,
-0.25357288122177124,
-0.015194711275398731,
-0.0035719596780836582,
0.10425637662410736,
0.036911819130182266,
0.2059554010629654,
-0.19964393973350525,
-0.19536258280277252,
-0.2842199504375458,
-0.035655293613672256,
0.1019604280591011,
0.3226490616798401,
0.3967786133289337,
0.1823491007089615,
0.2236987054347992,
0.2023654580116272,
0.07974924892187119,
0.18584896624088287,
-0.03589180111885071,
0.11465353518724442,
-0.043206799775362015,
-0.09881577640771866,
-0.4267226457595825,
-0.07594850659370422,
0.13770808279514313,
-0.21735380589962006,
0.18786874413490295,
0.01994471810758114,
0.24453720450401306,
-0.23521243035793304,
-0.1053219735622406,
-0.08284176141023636,
0.035491280257701874,
-0.007361896336078644,
0.24779385328292847,
-0.004242845810949802,
0.09935565292835236,
-0.25557997822761536,
0.23088888823986053,
0.13616307079792023,
-0.24577800929546356,
0.12801653146743774,
0.017435090616345406,
0.16271863877773285,
0.06226695328950882,
-0.046742793172597885,
-0.11039263755083084,
-0.05881224200129509,
-0.28293704986572266,
-0.09488573670387268,
0.16351495683193207,
0.14752495288848877,
-0.047487691044807434,
-0.16485092043876648,
-0.05727631598711014,
-0.11697385460138321,
-0.22723807394504547,
0.24853156507015228,
0.009254105389118195,
0.21351149678230286,
0.10149414092302322,
0.41443225741386414,
-0.08158136904239655,
-0.051951292902231216,
-0.028407927602529526,
0.08604074269533157,
-0.27917182445526123,
0.1746915578842163,
-0.053024426102638245,
0.10501644015312195,
-0.09270229935646057,
-0.11221934854984283,
-0.23808611929416656,
0.23089173436164856,
-0.08245527744293213,
-0.23814013600349426,
-0.031580980867147446,
0.005824028979986906,
-0.22169053554534912,
0.11136225610971451,
-0.2159968763589859,
-0.28967365622520447,
0.16233454644680023,
-0.10900755226612091,
0.1349814236164093,
-0.44472330808639526,
-0.04233193024992943,
0.2745586037635803,
-0.21566733717918396,
-0.03228168189525604,
0.1469988375902176,
-0.19235187768936157,
0.008488181047141552,
0.21038706600666046,
-0.1895478218793869,
-0.285907506942749,
0.04747835546731949,
-0.3624976575374603,
-0.09053898602724075,
0.03643980622291565,
-0.12378818541765213,
-0.09554851055145264,
0.042962446808815,
-0.10141099244356155,
0.2046172022819519,
-0.25087788701057434,
-0.0014830806758254766,
-0.10367707908153534,
0.34076106548309326,
-0.2428366243839264,
0.002891346113756299,
-0.4087289571762085,
0.0450974777340889,
-0.18845254182815552,
-0.012547232210636139,
0.025707783177495003,
0.06966058164834976,
-0.13856923580169678,
-0.14885585010051727,
0.028859244659543037,
-0.15736107528209686,
-0.07083642482757568,
0.022354871034622192,
0.13445346057415009,
-0.06710854917764664,
-0.25433728098869324,
-0.19553673267364502,
0.10613392293453217,
-0.11827792972326279,
0.011791233904659748,
-0.04412727430462837,
-0.24916797876358032,
-0.036489102989435196,
0.03182895854115486,
0.16733406484127045,
-0.07369024306535721,
-0.027892598882317543,
-0.1017867848277092,
0.10197587311267853,
-0.052520524710416794,
-0.17734229564666748,
-0.13420559465885162,
0.16301357746124268,
0.03917486220598221,
0.08997609466314316,
-0.22980445623397827,
-0.31267663836479187,
0.14534898102283478,
0.03681415691971779,
0.28397318720817566,
-0.20881624519824982,
-0.03824402019381523,
0.14262866973876953,
0.12276454269886017,
0.0707099586725235,
0.107549287378788,
-0.017103377729654312,
-0.15548746287822723,
0.1512271761894226,
-0.08012016862630844,
0.0547274686396122,
0.02320868894457817,
0.06057962030172348,
0.03117373026907444,
-0.062384478747844696,
0.28663524985313416,
0.26200106739997864,
-0.09263402968645096,
0.07449257373809814,
0.23936480283737183,
0.1954900026321411,
0.10171762853860855,
-0.03469537943601608,
0.13725906610488892,
-0.3332151770591736,
-0.17055128514766693,
-0.022567754611372948,
-0.09543922543525696,
-0.07467614114284515,
0.37198159098625183,
0.4159556031227112,
0.1497456133365631,
-0.1750158667564392,
-0.18187205493450165,
0.009386993944644928,
-0.10525583475828171,
-0.034577470272779465,
-0.0866827443242073,
0.15923255681991577,
0.058141548186540604,
0.08289987593889236,
-0.14693064987659454,
0.1369582712650299,
-0.10777416080236435,
-0.0050532883033156395,
-0.14259429275989532,
-0.05032123997807503,
0.07004405558109283,
0.02627350203692913,
-0.1385021209716797,
0.24253998696804047,
-0.17405052483081818,
0.17444397509098053,
-0.08567813783884048,
-0.06776060909032822,
0.3948685824871063,
-0.14960607886314392,
0.119902603328228,
-0.10129259526729584,
-0.17415037751197815,
-0.09997443109750748,
0.1245805099606514,
-0.2814989387989044,
0.07725702226161957,
-0.2806304097175598,
-0.19580428302288055,
0.021874701604247093,
0.006044657900929451,
0.15611858665943146,
0.13823248445987701,
-0.13302312791347504,
-0.10411515831947327,
0.13576291501522064,
-0.007192671764642,
-0.0739964097738266,
0.09234441071748734,
-0.19263185560703278,
-0.10315173119306564,
0.007885118946433067,
0.11644641309976578,
-0.026601020246744156,
-0.4301091134548187,
-0.0628238394856453,
0.21093516051769257,
0.02221054583787918,
-0.06503676623106003,
-0.10538098961114883,
-0.13573779165744781,
0.0940953716635704,
0.09238210320472717,
-0.09053845703601837,
0.027887670323252678,
0.11893576383590698,
0.09521769732236862,
0.08622044324874878,
0.06080223247408867,
-0.0006449709180742502,
-0.018091462552547455,
0.049388449639081955,
-0.15642891824245453,
-0.18888171017169952,
0.07603739947080612,
0.059072159230709076,
-0.026464149355888367,
0.05240081995725632,
0.00701535027474165,
0.013048849999904633,
0.08014432340860367,
0.22565482556819916,
0.10591024905443192,
-0.4945988357067108,
-0.0903894379734993,
0.18529826402664185,
0.14525195956230164,
0.17351172864437103,
0.0634031668305397,
0.11204802244901657,
0.004894869867712259,
0.06750721484422684,
-0.15700267255306244,
0.10218758136034012,
-0.06579404324293137,
0.03451411798596382,
0.1778496652841568,
0.2590489983558655,
0.1443110704421997,
-0.035854510962963104,
-0.11055098474025726,
0.20028570294380188,
-0.08660385757684708,
-0.08827119320631027,
-0.24450314044952393,
-0.11552420258522034,
-0.06716200709342957,
-0.07180676609277725,
0.07660525292158127,
-0.120575912296772,
-0.1631525754928589,
0.1108124703168869,
0.12886880338191986,
0.012355931103229523,
0.12317196279764175,
0.12311865389347076,
0.09534400701522827,
-0.22046273946762085,
-0.2303449958562851,
0.21790394186973572,
0.16093312203884125,
-0.017397163435816765,
0.10532400757074356,
0.17752200365066528,
0.3751349449157715,
0.02588742971420288,
-0.020136211067438126,
-0.09124933183193207,
-0.08315419405698776,
-0.07303974032402039,
-0.3471934199333191,
-0.11740565299987793,
0.10185115784406662,
0.05425092577934265,
0.006286422722041607,
-0.15794014930725098,
-0.2615349590778351,
0.06898573040962219,
-0.07205107063055038,
-0.06487961113452911,
0.04523381590843201,
0.2332753986120224,
0.10265713185071945,
0.15399110317230225,
0.1994454711675644,
-0.02762611210346222,
0.012081608176231384,
-0.036650869995355606,
0.14703790843486786,
-0.10566026717424393,
-0.004414634313434362,
0.05941827595233917,
0.15086999535560608,
0.0019914736039936543,
-0.2195928394794464,
0.13047289848327637,
0.2715597450733185,
-0.15446020662784576,
-0.3129343092441559,
0.1559569388628006,
-0.15943793952465057,
-0.04420099034905434,
0.13417001068592072,
-0.07897882908582687,
0.25411316752433777,
0.04684099555015564,
-0.14412780106067657,
0.13913126289844513,
-0.007607848849147558,
0.03215998411178589,
0.2095583975315094,
0.039012398570775986,
-0.05685076117515564,
0.2588372826576233,
-0.0509503148496151,
-0.12848876416683197,
-0.08279119431972504,
-0.09898819774389267,
-0.16915066540241241,
0.20408059656620026,
-0.22231516242027283,
-0.11407530307769775,
0.4195201098918915,
-0.26383039355278015,
0.0009712697938084602,
-0.09353309124708176,
-0.06559471040964127,
0.2544443905353546,
-0.12030937522649765,
-0.11475800722837448,
0.019452806562185287,
-0.09557796269655228,
0.023348616436123848,
-0.061151836067438126,
0.01764827035367489,
-0.1806706190109253,
-0.006410709582269192,
0.050394896417856216,
-0.04383181408047676,
0.051243267953395844,
0.09316740930080414,
-0.08690178394317627,
0.019992858171463013,
0.2807214856147766,
0.04642106592655182,
0.2690579295158386,
-0.12169427424669266,
-0.005656608380377293,
-0.09206452965736389,
-0.25759944319725037,
-0.06798351556062698,
0.2343045324087143,
0.10025447607040405,
-0.020275048911571503,
0.23741978406906128,
0.10126831382513046,
-0.0005505839944817126,
0.004119874909520149,
0.15843909978866577,
-0.0071556298062205315,
-0.04928695783019066,
0.14430442452430725,
-0.06574100255966187,
-0.18724477291107178,
0.29216620326042175,
-0.20412296056747437,
-0.05849583074450493,
-0.028609951958060265,
0.28264951705932617,
0.2139820009469986,
-0.028180936351418495,
-0.060276105999946594,
-0.009982043877243996,
-0.13123147189617157,
0.14330808818340302,
-0.03826744109392166,
-0.09971669316291809,
0.1634136289358139,
-0.35037198662757874,
0.1665857434272766,
-0.04646891728043556,
0.0859212875366211,
0.21195094287395477,
-0.055530842393636703,
-0.08683080971240997,
-0.13229137659072876,
-0.10052668303251266,
0.07101207971572876,
0.12732870876789093,
-0.21169136464595795,
-0.152765154838562,
-0.18425790965557098,
-0.1375422477722168,
0.01663757488131523,
-0.0038863150402903557,
0.019721081480383873,
-0.26228275895118713,
0.14875726401805878,
-0.30943796038627625,
0.07266929745674133,
-0.2085287719964981,
-0.2596723735332489,
-0.0021789083257317543,
-0.25955790281295776,
-0.008402284234762192,
0.016792580485343933,
-0.032842006534338,
-0.18948817253112793,
-0.09945210069417953,
0.2077677845954895,
-0.07929112762212753,
-0.4074151813983917,
-0.2894008159637451,
0.047200318425893784,
-0.0811983272433281,
-0.17494530975818634,
0.17524093389511108,
-0.033972688019275665,
0.21650590002536774,
-0.13079175353050232,
-0.13883501291275024,
-0.005380027927458286,
0.25320446491241455,
-0.042729225009679794,
0.19540241360664368,
-0.08317358791828156,
-0.0003621455980464816,
0.06910350173711777,
-0.07632055878639221,
-0.22310444712638855,
0.21385718882083893,
-0.16983996331691742,
-0.036010634154081345,
0.11061836034059525,
0.10530029982328415,
0.04855053871870041,
0.05888412147760391,
-0.040947332978248596,
0.001762952539138496,
-0.07849136739969254,
0.13941313326358795,
-0.09484787285327911,
-0.3832426369190216,
0.18575453758239746,
-0.03049147129058838,
-0.023633023723959923,
-0.0930970311164856,
-0.0685187354683876,
-0.05448848009109497,
0.18937557935714722,
0.28035905957221985,
-0.01162799634039402,
0.035265516489744186,
0.11966810375452042,
0.28290078043937683,
-0.22734709084033966,
0.2684735357761383,
-0.011428697034716606,
-0.06561990082263947,
0.10532751679420471,
-0.10367696732282639,
-0.08478855341672897,
-0.01016389299184084,
-0.0668506920337677,
0.17693395912647247,
0.3978693187236786,
-0.014585220254957676,
-0.10860645025968552,
0.05988512560725212,
0.009570639580488205,
0.037117209285497665,
0.01208584289997816,
-0.13834790885448456,
0.29165855050086975,
-0.047428030520677567,
0.03775201737880707,
0.00273900362662971,
-0.011046524159610271,
-0.21320872008800507,
-0.02446923591196537,
-0.2201482504606247,
0.08647212386131287,
-0.008635920472443104,
-0.22799958288669586,
-0.006177197210490704,
0.12203112244606018,
0.11457255482673645,
0.05475351959466934,
0.2491464763879776,
-0.10858578234910965,
0.22610731422901154,
-0.14094428718090057,
0.11303722113370895,
-0.13988207280635834,
0.04241951182484627,
-0.0254189632833004,
-0.03199128061532974,
-0.023414304479956627,
-0.030329043045639992,
0.12877359986305237,
-0.07149729132652283,
-0.18990333378314972,
0.15154677629470825,
-0.1924678385257721,
-0.23602691292762756,
-0.12324389815330505,
0.0855492576956749,
0.047620490193367004,
0.04050612077116966,
0.236813485622406,
0.09850003570318222,
0.09641779214143753,
-0.15051759779453278,
0.24352054297924042,
0.15359310805797577,
-0.3114085793495178,
-0.31646785140037537,
0.09809095412492752,
0.013615012168884277,
0.09828995913267136,
0.14285412430763245,
-0.11000595986843109,
-0.04970929026603699,
-0.189069002866745,
0.0574386864900589,
-0.005008324049413204,
0.06542758643627167,
0.04663459211587906,
-0.04592864215373993,
0.2645476162433624,
0.4063507616519928,
-0.16577786207199097,
-0.24027536809444427,
-0.31545490026474,
-0.06748522818088531,
-0.02684072032570839,
0.026538681238889694,
0.11957260966300964,
-0.03722356632351875,
-0.142231747508049,
0.17070156335830688,
-0.035608239471912384,
0.02880730852484703,
-0.05931820347905159,
-0.16691242158412933,
-0.19894948601722717,
-0.14695940911769867,
-0.060585882514715195,
-0.16512234508991241,
-0.0028997173067182302,
-0.054201897233724594,
0.3000616729259491,
0.005204913672059774,
-0.1178470104932785,
-0.0016300433780997992,
0.005371931474655867,
-0.037481676787137985,
-0.19485847651958466,
-0.006841501221060753,
-0.057156383991241455,
-0.015051908791065216,
0.26594430208206177,
0.03133106231689453,
0.007070801220834255,
-0.09978322684764862,
-0.048028960824012756,
-0.24475233256816864,
-0.07627084106206894,
-0.06463215500116348,
0.07663494348526001,
0.02838565967977047,
-0.18069811165332794,
0.05819360539317131,
-0.04875914379954338,
0.025670086964964867,
0.16671313345432281,
0.11859890818595886,
-0.09267944097518921,
0.11347375810146332,
0.12394025921821594,
0.022258490324020386,
0.0010007634991779923,
-0.2871810495853424,
-0.09381911903619766,
-0.01829424314200878,
0.16358904540538788,
0.06670347601175308,
0.14773641526699066,
0.05092919245362282,
0.014404769986867905,
0.02380593866109848,
-0.03274662420153618,
0.12297263741493225,
-0.04382825642824173,
-0.09035483747720718,
-0.005899724084883928,
-0.02712276019155979,
0.13365352153778076,
-0.008224918507039547,
0.34454941749572754,
0.053131598979234695,
0.09711039066314697
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. to improve adherence in chronic management of PA.Medications may include: L-carnitine supplementation to enhance excretion of propionic acid and oral metronidazole to reduce propionate production by gut bacteria. Orthotopic liver transplantation (OLT) may be indicated in those with frequent metabolic decompensations, uncontrollable hyperammonemia, and/or poor growth.Prevention of secondary complications: Consistent evaluation of the protein intake, depending on age, gender, severity of disorder and presence of other factors such as intercurrent illness, surgery, level of physical activity, and growth spurts to avoid insufficient or excessive protein restriction. Excessive protein restriction can result in deficiency of essential amino acids and impaired growth, as well as catabolism-induced metabolic decompensation.Surveillance: Monitor closely patients with a catabolic stressor (fasting, fever, illness, injury, and surgery) to prevent and/or detect and manage metabolic decompensations early. Regularly assess: (1) growth, nutritional status, feeding ability, psychomotor development; (2) vision | [
-0.09618925303220749,
-0.050115130841732025,
-0.20290495455265045,
-0.30229198932647705,
0.07709342986345291,
0.055863942950963974,
0.12037654221057892,
-0.2661302983760834,
0.03717682510614395,
-0.08796791732311249,
0.2585771679878235,
-0.010600768029689789,
-0.046354860067367554,
-0.011601025238633156,
-0.41235730051994324,
0.013915445655584335,
-0.10454720258712769,
-0.0024569849483668804,
0.023834632709622383,
-0.04444313421845436,
0.18640759587287903,
-0.17543965578079224,
0.06795576214790344,
0.1314094513654709,
0.19212332367897034,
-0.03818758949637413,
0.18081894516944885,
-0.2015312761068344,
0.1842237114906311,
-0.05946940928697586,
0.0483369417488575,
0.040121860802173615,
0.04586467146873474,
-0.29341015219688416,
-0.03322027623653412,
-0.29989758133888245,
-0.1642490178346634,
-0.3011454641819,
0.05698525905609131,
-0.13175442814826965,
0.14640317857265472,
-0.1922997385263443,
0.17753636837005615,
0.06507642567157745,
0.14496161043643951,
-0.04517412185668945,
0.017941078171133995,
-0.12218673527240753,
-0.08019408583641052,
0.3231256604194641,
-0.12025342136621475,
-0.21513213217258453,
-0.3070959448814392,
-0.09428969025611877,
0.2687508463859558,
-0.25312358140945435,
-0.12971635162830353,
0.1356184482574463,
-0.15326730906963348,
0.11636294424533844,
0.11257348209619522,
-0.3183249235153198,
-0.15436728298664093,
-0.32110917568206787,
0.10284671187400818,
0.03229857608675957,
-0.1626688539981842,
0.1450755000114441,
0.33345383405685425,
-0.19273003935813904,
0.09991200268268585,
-0.03678310289978981,
-0.1438555121421814,
0.09167729318141937,
0.002475930377840996,
-0.04511328041553497,
0.16782471537590027,
-0.060785289853811264,
0.12191753834486008,
-0.32258161902427673,
-0.21484002470970154,
0.03235209360718727,
-0.028689619153738022,
-0.2634373605251312,
-0.010184883140027523,
0.1547955870628357,
0.20734068751335144,
-0.043550264090299606,
0.045600708574056625,
0.03092653676867485,
0.07331310212612152,
0.04454013332724571,
0.005228265654295683,
0.1922779083251953,
0.041872333735227585,
-0.21023792028427124,
0.11151235550642014,
-0.12473395466804504,
-0.16087454557418823,
0.20985718071460724,
0.22372545301914215,
0.08667399734258652,
0.0022933841682970524,
-0.01172433327883482,
-0.047232262790203094,
0.001792542519979179,
-0.18490324914455414,
0.055693671107292175,
-0.012870271690189838,
0.0531482920050621,
0.08567213267087936,
-0.2323817014694214,
0.21928294003009796,
0.0630299374461174,
-0.3547796308994293,
-0.18486027419567108,
0.0685812458395958,
0.2647334039211273,
0.1364137828350067,
-0.22521372139453888,
0.053071752190589905,
0.21360193192958832,
0.050819817930459976,
0.040242284536361694,
0.061701029539108276,
0.04599287733435631,
0.1510038822889328,
0.016306310892105103,
0.22589392960071564,
-0.17116665840148926,
0.071068175137043,
-0.1121540442109108,
0.03788195922970772,
-0.06211601942777634,
0.14327673614025116,
-0.1382099837064743,
-0.3459920585155487,
-0.34983378648757935,
0.14172682166099548,
0.13619081676006317,
0.2989427149295807,
0.30540382862091064,
0.20110222697257996,
0.08754728734493256,
0.21459588408470154,
0.08734813332557678,
0.27750495076179504,
0.001191752846352756,
-0.002173670567572117,
0.04404279217123985,
-0.060422495007514954,
-0.24603214859962463,
0.0582103468477726,
0.052228957414627075,
-0.10576123744249344,
0.13690443336963654,
-0.16207291185855865,
0.19379371404647827,
-0.14596036076545715,
-0.19650061428546906,
-0.060693733394145966,
0.03544656187295914,
0.13125121593475342,
0.18609604239463806,
-0.08055825531482697,
0.14138096570968628,
-0.25155773758888245,
0.17047733068466187,
0.13953182101249695,
-0.16682030260562897,
0.05706790089607239,
-0.017028063535690308,
-0.029881346970796585,
-0.008291537873446941,
-0.04533453658223152,
-0.052652206271886826,
-0.11029567569494247,
-0.2389509379863739,
-0.06373552978038788,
0.236541748046875,
0.215922012925148,
-0.04381659999489784,
-0.17407728731632233,
-0.02973538264632225,
0.001829491346143186,
-0.08853597939014435,
0.23002196848392487,
0.12548114359378815,
0.08214860409498215,
0.25246044993400574,
0.29212796688079834,
0.09813620895147324,
-0.12795782089233398,
-0.11891490966081619,
0.12405669689178467,
-0.1711416095495224,
0.18010634183883667,
0.02844352275133133,
-0.012655711732804775,
-0.14882192015647888,
0.00018466042820364237,
-0.2556447982788086,
0.17356954514980316,
-0.15743951499462128,
-0.2159191370010376,
-0.14601171016693115,
-0.03136063367128372,
-0.11498937755823135,
0.15103678405284882,
-0.03419550880789757,
-0.14723747968673706,
0.027562545612454414,
-0.07771925628185272,
0.004102638922631741,
-0.3144354224205017,
-0.020488860085606575,
0.0691809207201004,
-0.10306859761476517,
0.04958252236247063,
0.11713346838951111,
-0.2105444371700287,
-0.060789160430431366,
0.05048764869570732,
-0.15291282534599304,
-0.2693556249141693,
0.01599443145096302,
-0.31160181760787964,
-0.16313959658145905,
-0.021687716245651245,
-0.14150309562683105,
-0.23424208164215088,
-0.003414697479456663,
0.07366745918989182,
0.2651887834072113,
-0.15855281054973602,
0.022018548101186752,
-0.15054203569889069,
0.31802231073379517,
-0.19585934281349182,
0.008596864528954029,
-0.4091987907886505,
0.0633106678724289,
0.01946931891143322,
-0.1555284559726715,
0.15064290165901184,
0.1435571163892746,
0.05594031140208244,
0.02829114720225334,
-0.10099019855260849,
-0.05060207471251488,
0.02181532233953476,
0.04163723066449165,
0.11953797936439514,
-0.01878875494003296,
-0.38745272159576416,
0.010129290632903576,
0.158819779753685,
-0.06774090230464935,
-0.10294988006353378,
-0.11780986934900284,
-0.21406221389770508,
-0.0034487310331314802,
0.22131219506263733,
0.058366429060697556,
0.061343543231487274,
0.01392497681081295,
-0.08752544969320297,
0.11651567369699478,
0.1232510656118393,
-0.19309380650520325,
-0.03526388481259346,
0.14171238243579865,
0.105438731610775,
0.09258753061294556,
-0.2573951780796051,
-0.16899822652339935,
-0.028791185468435287,
0.1491522341966629,
0.30700650811195374,
-0.13877303898334503,
-0.00015238040941767395,
0.11856058239936829,
0.08747989684343338,
0.09214135259389877,
0.09824436157941818,
-0.0024819080717861652,
-0.0034195214975625277,
0.04495026171207428,
0.027777288109064102,
0.11269742995500565,
0.029837513342499733,
0.10457585006952286,
-0.15606512129306793,
-0.03992484509944916,
0.08590641617774963,
0.10038045793771744,
-0.14347505569458008,
0.15185502171516418,
0.07004248350858688,
0.11300145834684372,
0.002548307180404663,
0.1250230222940445,
0.02288428135216236,
0.015464470721781254,
-0.27039581537246704,
0.04744326323270798,
-0.049847401678562164,
0.08958562463521957,
0.12956783175468445,
0.2886334955692291,
0.0660981759428978,
-0.23538509011268616,
-0.1845356822013855,
0.0189924668520689,
-0.07747393101453781,
0.005987726151943207,
-0.14894595742225647,
0.17333577573299408,
0.0538264624774456,
0.14676472544670105,
0.003021315671503544,
0.04629243165254593,
-0.05210436135530472,
0.07614793628454208,
-0.08007647097110748,
-0.04041481390595436,
-0.004778231959789991,
0.13423798978328705,
-0.04018668830394745,
0.037143073976039886,
-0.13558326661586761,
0.1821451634168625,
0.04069461300969124,
-0.0536724254488945,
0.2035583257675171,
-0.23485995829105377,
0.2191804200410843,
-0.03447520360350609,
-0.030701756477355957,
0.054462771862745285,
0.06293681263923645,
-0.379348486661911,
-0.03876971825957298,
-0.20955602824687958,
-0.21153374016284943,
0.07134281098842621,
0.025947852060198784,
0.033167559653520584,
0.008969209156930447,
0.029022332280874252,
-0.06057123467326164,
-0.025048866868019104,
-0.08723565191030502,
-0.1800210326910019,
0.19636861979961395,
0.005856706760823727,
-0.0925881639122963,
0.11136957257986069,
0.1278848946094513,
-0.000022845331841381267,
-0.2876231372356415,
0.05007711797952652,
0.2147805094718933,
-0.07846082746982574,
-0.045197341591119766,
-0.10830022394657135,
-0.15272432565689087,
-0.12755128741264343,
0.24291135370731354,
-0.06944651901721954,
0.0028604192193597555,
0.1664840430021286,
0.125959575176239,
0.023973725736141205,
-0.010827661491930485,
0.09441112726926804,
0.03287471458315849,
0.014526036567986012,
-0.1661868542432785,
-0.07555761933326721,
0.15463221073150635,
-0.022429808974266052,
0.054350417107343674,
-0.13672085106372833,
0.05602168291807175,
-0.005877888761460781,
-0.018207570537924767,
0.12424714863300323,
0.17706042528152466,
-0.5000501275062561,
-0.07979542016983032,
0.22625795006752014,
0.08045138418674469,
0.24966712296009064,
0.09826729446649551,
0.18043088912963867,
-0.11054228991270065,
0.03162021562457085,
-0.2205296903848648,
0.1376625895500183,
-0.0026036982890218496,
-0.04587048292160034,
0.17823614180088043,
0.1839456856250763,
0.09073872864246368,
-0.157822385430336,
0.0604453943669796,
0.11378509551286697,
-0.02438513934612274,
0.18408428132534027,
-0.08168476074934006,
-0.08367287367582321,
-0.0944376289844513,
-0.022578971460461617,
0.02219889685511589,
-0.07241590321063995,
-0.19101078808307648,
0.17488782107830048,
0.27030354738235474,
-0.21302387118339539,
-0.056731343269348145,
-0.012627789750695229,
0.09116391092538834,
-0.1441742330789566,
-0.10935374349355698,
0.1459626704454422,
0.1434217393398285,
0.04665948450565338,
0.10438243299722672,
0.23674792051315308,
0.2483653575181961,
0.08388391882181168,
0.0020420034416019917,
0.008323651738464832,
0.05468553304672241,
0.03755303472280502,
-0.22573179006576538,
-0.00035966018913313746,
0.04554802179336548,
-0.08319871872663498,
0.059851448982954025,
-0.04698377475142479,
-0.1022326648235321,
0.008642290718853474,
-0.058528799563646317,
-0.057801928371191025,
0.03900898993015289,
0.29549986124038696,
0.0783245712518692,
0.0705856904387474,
0.07237754762172699,
-0.07601422816514969,
0.021690476685762405,
0.02390783466398716,
0.20725591480731964,
0.015707820653915405,
-0.030950427055358887,
-0.04784127324819565,
0.05827328935265541,
0.04884474724531174,
-0.2896817922592163,
0.019140729680657387,
0.24414047598838806,
-0.16917014122009277,
-0.22547125816345215,
-0.027983494102954865,
-0.19088244438171387,
0.0697864219546318,
0.03721320629119873,
0.013868493027985096,
0.052051689475774765,
0.03585723042488098,
-0.08604153245687485,
0.10752211511135101,
-0.0003224429674446583,
-0.017876463010907173,
0.04554036259651184,
0.04774985462427139,
-0.021799474954605103,
0.24244573712348938,
-0.040240634232759476,
-0.1579952836036682,
-0.030104337260127068,
-0.1613348424434662,
-0.059311140328645706,
0.14069868624210358,
-0.23968179523944855,
-0.027365172281861305,
0.27170172333717346,
-0.14932219684123993,
0.0492277629673481,
-0.06654555350542068,
-0.16468489170074463,
0.3589012324810028,
-0.15690384805202484,
-0.16830579936504364,
0.028816111385822296,
-0.12655411660671234,
0.0907335877418518,
-0.08389358222484589,
0.0022766103502362967,
-0.08904172480106354,
-0.18472707271575928,
0.1225578635931015,
0.024709081277251244,
0.12318649888038635,
0.12965595722198486,
-0.1302119344472885,
-0.11711833626031876,
0.2081676423549652,
0.020552195608615875,
0.13908906280994415,
-0.07813892513513565,
0.04335503652691841,
-0.015629664063453674,
-0.33468762040138245,
0.07285087555646896,
0.19900302588939667,
-0.01981031894683838,
-0.11668992787599564,
0.25552237033843994,
0.06734060496091843,
-0.0021682698279619217,
0.05294075608253479,
0.10880117863416672,
0.011428064666688442,
-0.11778814345598221,
0.05594025179743767,
-0.15558373928070068,
-0.10299097001552582,
0.19893120229244232,
-0.2305871993303299,
-0.06298916786909103,
-0.10701178759336472,
0.10853231698274612,
0.04290139302611351,
-0.10457202792167664,
-0.05427239462733269,
-0.10490800440311432,
-0.16879624128341675,
0.15851716697216034,
-0.16155849397182465,
-0.07495516538619995,
0.24105286598205566,
-0.32972967624664307,
0.13979190587997437,
0.025887884199619293,
0.17417074739933014,
-0.035210225731134415,
0.016110345721244812,
0.04992930591106415,
-0.15878622233867645,
-0.1104215458035469,
0.14612329006195068,
0.05524852126836777,
-0.1680842638015747,
-0.02446897141635418,
-0.1490183025598526,
-0.2103131115436554,
0.09811709821224213,
-0.10069113969802856,
-0.03771107271313667,
-0.16939128935337067,
-0.02123657986521721,
-0.13878589868545532,
0.008680904284119606,
-0.023693744093179703,
-0.07698562741279602,
-0.10729911178350449,
-0.24488085508346558,
-0.03002619557082653,
-0.08371840417385101,
0.07610374689102173,
-0.13701143860816956,
-0.04825190454721451,
0.13650257885456085,
-0.18459060788154602,
-0.3632558584213257,
-0.3476298451423645,
0.10406042635440826,
-0.019338639453053474,
-0.15246087312698364,
0.08245808631181717,
-0.16805830597877502,
-0.02023545280098915,
-0.17412669956684113,
-0.04875272139906883,
-0.009260891936719418,
0.4387783110141754,
0.0012219164054840803,
0.03490808233618736,
-0.10726385563611984,
0.1976332813501358,
-0.07127143442630768,
0.03975321352481842,
-0.2208593785762787,
0.15295182168483734,
-0.2516556978225708,
-0.029812080785632133,
0.13451184332370758,
0.21588115394115448,
0.11903548985719681,
-0.030346643179655075,
-0.3943192660808563,
-0.23249340057373047,
-0.07528716325759888,
0.10977408289909363,
-0.12761564552783966,
-0.25616705417633057,
0.06083646044135094,
0.033951837569475174,
0.010422894731163979,
0.051653049886226654,
-0.048615653067827225,
-0.05182545259594917,
-0.013604968786239624,
0.2699393928050995,
-0.15149250626564026,
0.04411456361413002,
0.04482291638851166,
0.24899490177631378,
-0.08443573117256165,
0.28429460525512695,
0.0769536942243576,
-0.05528966337442398,
0.12092790752649307,
-0.06687530875205994,
-0.012428182177245617,
-0.09100198745727539,
-0.13834184408187866,
0.1491769701242447,
0.17506453394889832,
0.17153729498386383,
-0.011196916922926903,
-0.20328480005264282,
-0.10548358410596848,
0.056546516716480255,
0.1198480948805809,
-0.2238992154598236,
0.11428102105855942,
-0.16892491281032562,
0.05547991767525673,
0.05950075760483742,
0.07427146285772324,
-0.1760004758834839,
0.17895375192165375,
-0.17772018909454346,
-0.0065221041440963745,
0.05067571625113487,
-0.04842140153050423,
-0.007494162768125534,
0.028715504333376884,
-0.0473552867770195,
0.06276267766952515,
0.2517887055873871,
-0.11599357426166534,
-0.009683140553534031,
-0.15364204347133636,
0.14948458969593048,
-0.21782566606998444,
0.016436666250228882,
0.02581355907022953,
-0.04722381383180618,
-0.0885324478149414,
-0.015939943492412567,
0.23198802769184113,
0.03814208507537842,
-0.11687087267637253,
0.13666412234306335,
-0.05025722086429596,
-0.17490242421627045,
0.041259460151195526,
-0.03095194324851036,
0.18072015047073364,
0.08764828741550446,
0.17164307832717896,
0.004327753093093634,
0.17095857858657837,
-0.2186819165945053,
0.35819169878959656,
-0.02786385640501976,
-0.2983645498752594,
-0.35551077127456665,
-0.0638204887509346,
0.20879143476486206,
0.1191709041595459,
0.01763118803501129,
-0.024822987616062164,
0.08825204521417618,
-0.2919447422027588,
0.15001153945922852,
-0.06505844742059708,
-0.04222387820482254,
0.06080642715096474,
-0.15209777653217316,
-0.056970320641994476,
0.2526237666606903,
-0.07614258676767349,
-0.34807661175727844,
-0.21944719552993774,
-0.009069837629795074,
-0.0707068145275116,
0.009253112599253654,
0.16333656013011932,
-0.0011384779354557395,
-0.25746220350265503,
0.20994867384433746,
-0.14131027460098267,
0.059595316648483276,
-0.20553314685821533,
-0.3014075756072998,
-0.07431721687316895,
-0.11228780448436737,
0.09835826605558395,
-0.039821807295084,
0.11917104572057724,
-0.06838268041610718,
0.2774788737297058,
0.02668510563671589,
-0.11653613299131393,
-0.01803574711084366,
0.07830321788787842,
-0.09830527007579803,
-0.030318589881062508,
0.1267707496881485,
-0.032815270125865936,
0.08426035195589066,
0.1706683486700058,
0.10647904127836227,
-0.06305842846632004,
-0.20602408051490784,
-0.13793392479419708,
-0.2645721435546875,
0.03766823559999466,
0.07107337564229965,
0.11435937136411667,
-0.031770460307598114,
-0.20684689283370972,
0.14923948049545288,
-0.11850550025701523,
-0.15458044409751892,
0.05543529614806175,
0.0762341096997261,
-0.0776953175663948,
0.03437545895576477,
0.12559448182582855,
-0.13215894997119904,
-0.04847852885723114,
-0.12091267108917236,
-0.13487033545970917,
0.021286655217409134,
-0.01825830712914467,
-0.10771861672401428,
0.1265200674533844,
-0.06255669891834259,
0.023421628400683403,
-0.21309764683246613,
-0.15038524568080902,
0.019036132842302322,
0.022178512066602707,
-0.050954509526491165,
-0.17136803269386292,
-0.08435399830341339,
0.14474818110466003,
0.04020287096500397,
0.2404981106519699,
0.05193663388490677,
0.2691974639892578
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. illness, surgery, level of physical activity, and growth spurts to avoid insufficient or excessive protein restriction. Excessive protein restriction can result in deficiency of essential amino acids and impaired growth, as well as catabolism-induced metabolic decompensation.Surveillance: Monitor closely patients with a catabolic stressor (fasting, fever, illness, injury, and surgery) to prevent and/or detect and manage metabolic decompensations early. Regularly assess: (1) growth, nutritional status, feeding ability, psychomotor development; (2) vision and hearing (3) cardiac function for signs of cardiomyopathy; (4) metabolic status by monitoring urine organic acids and plasma amino acids; (5) complete blood count; (6) renal function.Agents/circumstances to avoid: Prolonged fasting, catabolic stressors, and excessive protein intake. Lactated Ringer’s solution is not recommended in patients with organic acidemias. In patients with QT abnormalities, avoid medications that can prolong the QT interval. Neuroleptic antiemetics (e. | [
0.03375553339719772,
0.07643331587314606,
-0.137333944439888,
-0.3015882670879364,
0.06711718440055847,
-0.0036331971641629934,
0.04363200441002846,
-0.273809015750885,
0.01936066895723343,
-0.10990701615810394,
0.17097540199756622,
-0.010458732955157757,
-0.08124246448278427,
-0.07743458449840546,
-0.41856759786605835,
0.041492313146591187,
-0.08918900042772293,
-0.13267554342746735,
-0.005498463753610849,
-0.0950835719704628,
0.1561993658542633,
-0.17433473467826843,
0.05518009886145592,
0.04331795498728752,
0.12336797267198563,
0.03323358669877052,
0.16758336126804352,
-0.18476951122283936,
0.2852860391139984,
0.07891698181629181,
-0.060799490660429,
0.14611171185970306,
0.007118623703718185,
-0.4367593824863434,
-0.018536686897277832,
-0.19093641638755798,
-0.14227204024791718,
-0.3155636489391327,
0.08616073429584503,
-0.18442337214946747,
-0.034037042409181595,
-0.13892866671085358,
0.09643647074699402,
0.011397705413401127,
0.011199017986655235,
-0.03950471431016922,
-0.02023710310459137,
-0.21536476910114288,
-0.11012297123670578,
0.23318183422088623,
-0.013264413923025131,
-0.16823293268680573,
-0.20703056454658508,
-0.1230054497718811,
0.24412211775779724,
-0.19053970277309418,
-0.23184970021247864,
0.11082924902439117,
-0.15337274968624115,
0.13291557133197784,
0.20393075048923492,
-0.18018421530723572,
-0.1324751079082489,
-0.22912158071994781,
0.03322196006774902,
0.07881084084510803,
-0.12582595646381378,
0.18075281381607056,
0.25534895062446594,
-0.034631725400686264,
0.22932249307632446,
-0.08923990279436111,
-0.11259948462247849,
0.1827533096075058,
-0.018563078716397285,
-0.012371349148452282,
0.17034505307674408,
-0.14039552211761475,
0.10585393011569977,
-0.27902108430862427,
-0.11833213269710541,
0.025060009211301804,
0.03617965802550316,
-0.25671297311782837,
-0.06309562176465988,
0.09471477568149567,
0.12711305916309357,
-0.1383620798587799,
-0.02293076552450657,
0.03019583970308304,
0.18638285994529724,
0.09670484066009521,
-0.021525006741285324,
0.0458080992102623,
-0.02689083106815815,
-0.08857765793800354,
0.07232161611318588,
0.04262367635965347,
-0.13889603316783905,
0.2746230959892273,
0.12104150652885437,
0.036131806671619415,
0.012470634654164314,
-0.10159416496753693,
0.01564386673271656,
0.07484422624111176,
-0.2141970545053482,
0.08607567846775055,
-0.09753112494945526,
-0.021348387002944946,
0.10197556763887405,
-0.14397981762886047,
0.02091265842318535,
0.18194909393787384,
-0.43269795179367065,
-0.025020644068717957,
0.1259099543094635,
0.3374885320663452,
0.155649796128273,
-0.01994621753692627,
-0.00592277105897665,
0.14812275767326355,
0.09767316281795502,
0.09753457456827164,
0.09971650689840317,
0.07632630318403244,
0.19259953498840332,
0.08468330651521683,
0.28847426176071167,
-0.058786481618881226,
0.0848923772573471,
-0.13382796943187714,
0.2033642828464508,
-0.03196980804204941,
0.13942860066890717,
-0.1107015311717987,
-0.2977960407733917,
-0.3327716588973999,
0.13821196556091309,
0.040444791316986084,
0.25321757793426514,
0.20737986266613007,
0.13133154809474945,
0.07164285331964493,
0.029508434236049652,
-0.017695732414722443,
0.3749177157878876,
0.07947687804698944,
0.061720412224531174,
0.15067020058631897,
0.03318903222680092,
-0.1905876249074936,
0.03505218029022217,
0.006518113426864147,
0.16319556534290314,
0.11525079607963562,
-0.19166840612888336,
0.22465258836746216,
-0.12950056791305542,
-0.13743391633033752,
-0.030123703181743622,
-0.0326278991997242,
0.09224050492048264,
0.05263849347829819,
-0.013697268441319466,
0.10855553299188614,
-0.20409251749515533,
0.1855008453130722,
0.11422640085220337,
-0.14779497683048248,
-0.14824330806732178,
0.017546527087688446,
0.023461682721972466,
-0.09642120450735092,
-0.07191991060972214,
0.01914922334253788,
-0.02744896709918976,
-0.11067303270101547,
-0.19263286888599396,
0.04996679350733757,
0.2519817352294922,
-0.002554698148742318,
-0.23149804770946503,
0.02737235277891159,
0.10989456623792648,
-0.13109391927719116,
0.27898430824279785,
0.21032226085662842,
0.06902391463518143,
0.23113316297531128,
0.2869274914264679,
0.09784980863332748,
-0.1029064729809761,
-0.14481313526630402,
-0.009248060174286366,
-0.14839500188827515,
0.18799589574337006,
-0.1128542348742485,
-0.06761395931243896,
-0.04736238345503807,
0.1439303457736969,
-0.2301492989063263,
0.07651922851800919,
-0.11101832985877991,
-0.11399960517883301,
-0.19292868673801422,
0.04217834025621414,
-0.10524894297122955,
0.19724403321743011,
0.08600904047489166,
0.013310163281857967,
0.08350244164466858,
-0.07638200372457504,
-0.040766604244709015,
-0.2288416177034378,
-0.0014616758562624454,
-0.06588529795408249,
-0.02234365977346897,
0.06105862185359001,
0.052995454519987106,
0.009671259671449661,
-0.04315393790602684,
-0.05934154987335205,
-0.23699304461479187,
-0.18423138558864594,
0.09339724481105804,
-0.2523149847984314,
-0.20774279534816742,
0.05428086221218109,
-0.05102774128317833,
-0.1659337878227234,
0.1329372078180313,
0.10837016999721527,
0.19486914575099945,
-0.1760815978050232,
0.04646487534046173,
-0.2699795961380005,
0.2073323279619217,
-0.0839352086186409,
-0.07505816221237183,
-0.4696284532546997,
0.14915457367897034,
0.06530583649873734,
-0.048284295946359634,
0.038364749401807785,
0.08827942609786987,
0.19669818878173828,
0.0032217937987297773,
-0.07506335526704788,
-0.027647219598293304,
0.07696608453989029,
0.06088264286518097,
0.06774146109819412,
-0.015425504185259342,
-0.30941522121429443,
-0.007304697763174772,
-0.0059273988008499146,
-0.042661309242248535,
-0.04743624106049538,
-0.13442116975784302,
-0.2207554429769516,
0.11146044731140137,
0.18074434995651245,
-0.058028001338243484,
0.17698436975479126,
0.05191325768828392,
-0.15094703435897827,
0.09363687038421631,
0.09147800505161285,
-0.2053627073764801,
-0.0979844480752945,
0.07517050951719284,
0.21415092051029205,
0.007432697806507349,
-0.2483687549829483,
-0.08140949159860611,
0.08494777977466583,
0.027437280863523483,
0.2124752551317215,
-0.1450788378715515,
-0.04313245415687561,
0.1440918743610382,
-0.09528125822544098,
0.011850908398628235,
-0.05523357167840004,
0.023794738575816154,
0.15495552122592926,
0.025564515963196754,
-0.07081855833530426,
0.22470344603061676,
0.04016702249646187,
0.056551139801740646,
-0.11482342332601547,
-0.02336416020989418,
0.071929931640625,
-0.11509408801794052,
-0.10005181282758713,
0.06219808757305145,
0.04355155676603317,
0.2631153464317322,
0.051732562482357025,
0.1287808120250702,
-0.019204245880246162,
0.0719546303153038,
-0.20855359733104706,
0.10890433937311172,
-0.018285252153873444,
-0.025653108954429626,
0.1982536017894745,
0.14027869701385498,
0.01159871555864811,
-0.11857903748750687,
-0.2486230731010437,
-0.014699481427669525,
0.008687902241945267,
-0.02726016566157341,
-0.00935476552695036,
0.03729654848575592,
0.07056868076324463,
0.2478182017803192,
0.06810175627470016,
-0.005808199755847454,
-0.012825029902160168,
0.05446593463420868,
-0.09640197455883026,
0.02168852835893631,
-0.017343169078230858,
0.26083263754844666,
-0.12797732651233673,
0.08151538670063019,
-0.17742274701595306,
0.10721835494041443,
-0.039822597056627274,
-0.041001614183187485,
0.14675331115722656,
-0.19283780455589294,
0.15113884210586548,
0.023859292268753052,
0.009831711649894714,
0.030635500326752663,
0.01954740844666958,
-0.4075639247894287,
-0.017314378172159195,
-0.168997660279274,
-0.1514127105474472,
0.1066780611872673,
0.023511968553066254,
0.04093807190656662,
0.09519843012094498,
-0.04329463839530945,
-0.16783343255519867,
-0.1755872219800949,
-0.03926459699869156,
-0.18418456614017487,
-0.10527276992797852,
-0.010787743143737316,
-0.1613420993089676,
0.12206783890724182,
0.07993826270103455,
-0.04788541793823242,
-0.19707556068897247,
0.00761945266276598,
0.11157242208719254,
-0.007477908860892057,
-0.025906290858983994,
-0.07640526443719864,
-0.21163493394851685,
-0.05469692870974541,
0.1474429965019226,
-0.03773069754242897,
0.19344040751457214,
0.04729946702718735,
0.1685427576303482,
0.026924772188067436,
-0.06316570937633514,
0.1776236593723297,
0.023644039407372475,
-0.15541331470012665,
-0.24090825021266937,
-0.05353545397520065,
0.12441043555736542,
0.01674138754606247,
0.10769699513912201,
-0.08227795362472534,
0.03426855802536011,
-0.07372206449508667,
-0.13066023588180542,
-0.015663130208849907,
0.16896140575408936,
-0.42142584919929504,
-0.1540922373533249,
0.13406777381896973,
0.1664155274629593,
0.13276804983615875,
-0.02300545945763588,
0.1263057291507721,
-0.05301861837506294,
0.1662784218788147,
-0.17513473331928253,
0.014059709385037422,
0.03696185350418091,
0.015496066771447659,
0.1707475334405899,
0.2073509395122528,
0.06467824429273605,
-0.01457835454493761,
0.08691038936376572,
0.10885035991668701,
-0.05902925878763199,
0.15501131117343903,
0.02874070219695568,
-0.12013451009988785,
-0.043671440333127975,
-0.13447391986846924,
-0.09262604266405106,
-0.10387849062681198,
-0.08158893883228302,
0.2356966882944107,
0.1370353102684021,
-0.12322743982076645,
-0.03932028263807297,
-0.016668567433953285,
0.04978540912270546,
0.06105800345540047,
-0.18289026618003845,
0.10689486563205719,
0.14282885193824768,
-0.0535423569381237,
0.11943723261356354,
0.06587091088294983,
0.30340176820755005,
0.2046612650156021,
0.07544290274381638,
0.06951170414686203,
0.02891862951219082,
0.042979586869478226,
-0.1794903576374054,
0.01263905968517065,
0.008739147335290909,
-0.13762228190898895,
0.11665093898773193,
0.09987081587314606,
-0.07930970191955566,
0.006921614054590464,
-0.04445255175232887,
0.11551669985055923,
0.10971973836421967,
0.17816342413425446,
0.1786365807056427,
0.022774014621973038,
0.1304047405719757,
-0.11336082220077515,
0.08513826131820679,
-0.059945497661828995,
0.1467323899269104,
0.09095347672700882,
0.046606916934251785,
-0.03295028954744339,
0.14388062059879303,
-0.12897422909736633,
-0.22222061455249786,
-0.0029483672697097063,
0.15183115005493164,
-0.06752819567918777,
-0.09504935145378113,
0.0562300905585289,
-0.2563280463218689,
0.05698903650045395,
-0.10102078318595886,
-0.05882001295685768,
-0.06768874078989029,
0.03883076831698418,
-0.1152256578207016,
0.0029458473436534405,
-0.056502703577280045,
-0.045032843947410583,
0.03985811769962311,
-0.03756142035126686,
-0.1686089038848877,
0.0841636136174202,
-0.04136635363101959,
-0.21230700612068176,
0.07335690408945084,
-0.06161057576537132,
-0.04219453036785126,
0.11294925957918167,
-0.1378393918275833,
0.10241906344890594,
0.13180987536907196,
0.023742588236927986,
0.02434498444199562,
-0.1477862298488617,
-0.040210824459791183,
0.44600751996040344,
-0.09304036945104599,
-0.2220384180545807,
0.02072262205183506,
-0.15110327303409576,
0.07568512111902237,
-0.21995319426059723,
-0.00012790791515726596,
-0.18118001520633698,
-0.1875065267086029,
0.08708459883928299,
0.0782940536737442,
-0.03815525770187378,
0.08159085363149643,
0.0058263991959393024,
-0.023480098694562912,
0.08613109588623047,
0.008699002675712109,
0.07050041109323502,
-0.06272972375154495,
0.05082894116640091,
0.00910820160061121,
-0.2386050820350647,
0.0431528277695179,
0.26147565245628357,
-0.0701909139752388,
-0.09207623451948166,
0.06762078404426575,
-0.05893980711698532,
0.1804015189409256,
-0.035263799130916595,
0.2184596210718155,
0.01575111597776413,
-0.004433434922248125,
-0.07114460319280624,
-0.031554948538541794,
-0.005619117058813572,
0.05688677355647087,
-0.1405642330646515,
-0.04713422432541847,
-0.06791646033525467,
0.28298357129096985,
-0.0706985592842102,
-0.05998695641756058,
-0.04291379824280739,
-0.03422032669186592,
-0.10290873050689697,
0.1359315812587738,
-0.16021664440631866,
0.05726821720600128,
0.2453562319278717,
-0.32032421231269836,
0.09154219180345535,
0.051446158438920975,
0.2290654331445694,
0.04309576004743576,
0.09550903737545013,
0.1234891265630722,
-0.2337075173854828,
0.006753097288310528,
0.06774839013814926,
-0.0012167614186182618,
-0.10401719808578491,
-0.04801200330257416,
-0.16174004971981049,
-0.07646864652633667,
0.01845177263021469,
-0.1507529467344284,
-0.09017185121774673,
-0.1936216503381729,
-0.006257874891161919,
-0.03668949007987976,
0.0366039015352726,
0.07388736307621002,
-0.1350569874048233,
-0.07912708818912506,
-0.20928387343883514,
-0.041323594748973846,
-0.10178706794977188,
0.02995886281132698,
-0.03411268815398216,
-0.04099813848733902,
0.14016203582286835,
-0.22168000042438507,
-0.4115596115589142,
-0.22053566575050354,
0.1269495189189911,
-0.019343141466379166,
-0.06325085461139679,
0.14088961482048035,
-0.14930620789527893,
0.04545237869024277,
-0.19654205441474915,
-0.015779102221131325,
0.12035222351551056,
0.4002155363559723,
-0.0007450540433637798,
0.043651923537254333,
-0.09959298372268677,
0.14459486305713654,
-0.231622576713562,
0.11999203264713287,
-0.21704746782779694,
0.1783178746700287,
-0.19189739227294922,
0.04698101431131363,
0.10538502037525177,
0.17664092779159546,
0.1111891120672226,
-0.16685645282268524,
-0.3285759389400482,
-0.30867236852645874,
-0.07232872396707535,
0.1839316487312317,
-0.19319015741348267,
-0.030701199546456337,
-0.09420505911111832,
0.08315420150756836,
0.05421112850308418,
0.17322640120983124,
-0.04933867231011391,
0.06138769909739494,
-0.1245422214269638,
0.22676274180412292,
-0.18996930122375488,
-0.025147493928670883,
-0.041078321635723114,
0.29401013255119324,
0.052188556641340256,
0.14919421076774597,
-0.008197053335607052,
-0.12446384131908417,
0.16862177848815918,
-0.011283820495009422,
-0.07352945953607559,
-0.1424410492181778,
-0.20040595531463623,
0.08843153715133667,
0.13507872819900513,
0.15373495221138,
0.010711457580327988,
-0.24796225130558014,
-0.14168238639831543,
0.010743848979473114,
0.24794667959213257,
-0.09905348718166351,
0.09485004842281342,
-0.1982048600912094,
0.22424279153347015,
-0.07141510397195816,
0.07991325110197067,
-0.10603713244199753,
0.2151927351951599,
-0.04169309511780739,
-0.19724386930465698,
-0.002854561898857355,
0.002787727862596512,
-0.04948527365922928,
0.09438078105449677,
-0.14070871472358704,
0.08773690462112427,
0.26665279269218445,
-0.2072373479604721,
-0.03902623429894447,
-0.026517970487475395,
0.05563616007566452,
-0.0688636526465416,
0.05851105973124504,
-0.13806696236133575,
0.010241738520562649,
-0.06317175179719925,
0.026034357026219368,
0.14663024246692657,
0.20935626327991486,
-0.02349405735731125,
-0.02766112983226776,
-0.046422965824604034,
-0.16263934969902039,
0.16020618379116058,
-0.14541471004486084,
0.14605969190597534,
0.15493327379226685,
0.19574931263923645,
0.02472332864999771,
0.04509163647890091,
-0.2345402091741562,
0.2327965646982193,
0.018190205097198486,
-0.35207465291023254,
-0.2476511299610138,
-0.17959360778331757,
0.167423278093338,
0.010160844773054123,
-0.00662185437977314,
-0.09169120341539383,
0.20130428671836853,
-0.3757530748844147,
0.1912708580493927,
-0.01563199982047081,
-0.011217029765248299,
0.14855019748210907,
-0.17647285759449005,
-0.16318699717521667,
0.23402352631092072,
-0.08477424830198288,
-0.27119675278663635,
-0.15557073056697845,
-0.08787893503904343,
0.026876015588641167,
0.0434734933078289,
0.12889619171619415,
-0.0692061334848404,
-0.13342984020709991,
0.15827268362045288,
-0.10098251700401306,
0.07848270237445831,
-0.10612515360116959,
-0.3143821656703949,
0.005902624689042568,
-0.14773981273174286,
0.18237905204296112,
0.021450592204928398,
0.2662620544433594,
0.009336971677839756,
0.11365225166082382,
-0.07959232479333878,
-0.24794653058052063,
0.04220160096883774,
0.1865316480398178,
-0.05975503474473953,
-0.019487077370285988,
0.08008723706007004,
0.09484469890594482,
0.027411775663495064,
0.1210356205701828,
0.015543636865913868,
-0.19832167029380798,
-0.22574640810489655,
-0.0887417122721672,
-0.2391068935394287,
-0.015626361593604088,
0.03861008957028389,
-0.07386346906423569,
-0.05981268361210823,
-0.26182329654693604,
0.11942572891712189,
-0.12181056290864944,
-0.25764408707618713,
-0.08340256661176682,
0.08255297690629959,
-0.03393601253628731,
0.03742489218711853,
0.1765652447938919,
-0.025027122348546982,
-0.030971568077802658,
0.02228154055774212,
-0.2169898897409439,
0.008174167945981026,
-0.08793792873620987,
0.02546451985836029,
0.11264819651842117,
0.0037787663750350475,
0.028606371954083443,
-0.22680342197418213,
-0.19274762272834778,
-0.10589062422513962,
0.04886037856340408,
-0.331341028213501,
-0.16716256737709045,
-0.029640737920999527,
0.2426958978176117,
0.08506593108177185,
0.1868719458580017,
0.169013112783432,
0.3860863149166107
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. development; (2) vision and hearing (3) cardiac function for signs of cardiomyopathy; (4) metabolic status by monitoring urine organic acids and plasma amino acids; (5) complete blood count; (6) renal function.Agents/circumstances to avoid: Prolonged fasting, catabolic stressors, and excessive protein intake. Lactated Ringer’s solution is not recommended in patients with organic acidemias. In patients with QT abnormalities, avoid medications that can prolong the QT interval. Neuroleptic antiemetics (e.g., promethazine) can mask symptoms of progressive encephalopathy and are best avoided.Evaluation of relatives at risk: Testing of at-risk sibs of a patient is warranted to allow for early diagnosis and treatment.Genetic counseling.Propionic acidemia is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected | [
0.05535149201750755,
0.10836883634328842,
-0.030790748074650764,
-0.24965237081050873,
0.2477230578660965,
0.018277613446116447,
-0.12334088236093521,
-0.18775495886802673,
0.08271332085132599,
-0.1551395207643509,
0.13204821944236755,
-0.03675064444541931,
-0.12325719743967056,
-0.13944678008556366,
-0.3480943441390991,
0.11220897734165192,
0.0018756367499008775,
0.0023015798069536686,
0.04719633609056473,
-0.09827358275651932,
0.006952532101422548,
-0.13839232921600342,
0.07982072234153748,
-0.11018835753202438,
0.21462832391262054,
-0.038054466247558594,
0.2893214225769043,
-0.30510327219963074,
0.15727797150611877,
0.1202128529548645,
-0.1606876254081726,
0.15131209790706635,
0.06595265120267868,
-0.413352906703949,
0.05211314186453819,
-0.11390908062458038,
-0.20189867913722992,
-0.40150684118270874,
0.1280878782272339,
-0.3760811686515808,
-0.06042640656232834,
0.03275200352072716,
0.0811772271990776,
-0.046588633209466934,
0.12371227145195007,
-0.15703842043876648,
0.01538076251745224,
-0.17188654839992523,
-0.14477980136871338,
0.12518614530563354,
0.09376972913742065,
-0.26639485359191895,
-0.1468120813369751,
-0.06525255739688873,
0.3133808970451355,
-0.1611458659172058,
-0.1767609417438507,
0.07646986842155457,
-0.11093360185623169,
0.0708848088979721,
0.11373069882392883,
-0.2529115676879883,
-0.08969330787658691,
-0.295885294675827,
0.1604253500699997,
-0.020044490694999695,
-0.0799546092748642,
0.18580284714698792,
0.2679733335971832,
-0.029785748571157455,
0.25297603011131287,
0.007835224270820618,
-0.05378783121705055,
0.07466796040534973,
-0.01858641766011715,
0.042055122554302216,
0.07934833317995071,
-0.1651809811592102,
-0.10649300366640091,
-0.08699032664299011,
-0.15702040493488312,
-0.016867900267243385,
0.14241936802864075,
-0.07798931747674942,
0.07555673271417618,
0.07578776776790619,
0.022600146010518074,
0.06214836984872818,
0.033699508756399155,
0.07774315774440765,
0.27284395694732666,
0.10513787716627121,
0.11506369709968567,
0.010929152369499207,
0.10396432131528854,
-0.017631923779845238,
0.1168474406003952,
0.06332692503929138,
-0.10181615501642227,
0.09207814186811447,
-0.13152672350406647,
-0.037315841764211655,
-0.17598660290241241,
-0.03129236400127411,
-0.008692099712789059,
0.1858752965927124,
-0.25735270977020264,
0.10985013097524643,
0.013744444586336613,
-0.013616111129522324,
0.20680156350135803,
-0.07958169281482697,
0.13979288935661316,
0.07578415423631668,
-0.4239536225795746,
-0.021939538419246674,
0.0705932080745697,
0.33781957626342773,
0.08909054845571518,
0.06164299324154854,
0.07693319767713547,
0.05374927446246147,
0.06835579872131348,
0.056768398731946945,
0.0795491561293602,
0.14923691749572754,
0.17012636363506317,
-0.005736988503485918,
0.3363647162914276,
0.026095066219568253,
0.11344032734632492,
-0.08298108726739883,
0.2200949341058731,
-0.02615138329565525,
0.14813409745693207,
-0.014881589449942112,
-0.2467576265335083,
-0.231722891330719,
-0.107431560754776,
0.003816773882135749,
0.26363545656204224,
0.10778692364692688,
0.1747765839099884,
0.18190473318099976,
0.02910543605685234,
0.0009257117053493857,
0.37889134883880615,
-0.03151553124189377,
0.10171115398406982,
0.1286858171224594,
-0.009307385422289371,
-0.09222732484340668,
0.06923695653676987,
-0.05091232806444168,
0.16029998660087585,
0.03329712897539139,
-0.12767809629440308,
0.21643154323101044,
-0.19354863464832306,
0.13555610179901123,
0.0027177734300494194,
-0.13020408153533936,
0.10809114575386047,
0.0410071536898613,
0.18522892892360687,
0.15137670934200287,
-0.29148048162460327,
0.14481961727142334,
-0.019616642966866493,
-0.2818674147129059,
-0.26509803533554077,
-0.05025124549865723,
0.2131870836019516,
-0.14038845896720886,
-0.12195912003517151,
0.03594920411705971,
-0.0014636374544352293,
0.045886896550655365,
-0.3774217665195465,
-0.04176841303706169,
0.21655084192752838,
0.1197466179728508,
-0.24265219271183014,
0.025218550115823746,
0.03254028782248497,
-0.18381088972091675,
0.3165183365345001,
0.16493193805217743,
0.017696907743811607,
0.16236519813537598,
0.2772005498409271,
0.040922921150922775,
0.06964566558599472,
-0.06163467839360237,
0.024807197973132133,
-0.32653018832206726,
0.12431711703538895,
-0.21268613636493683,
-0.04428362101316452,
-0.020142223685979843,
0.10458799451589584,
-0.1815241426229477,
0.08232073485851288,
-0.2111722230911255,
0.02892126701772213,
-0.1867414265871048,
0.14589425921440125,
-0.10106157511472702,
0.09748953580856323,
0.04769178107380867,
-0.14576101303100586,
0.23429225385189056,
-0.23746970295906067,
0.021049397066235542,
-0.3260292410850525,
-0.010134657844901085,
-0.10713022947311401,
-0.06324183195829391,
0.08558275550603867,
-0.05481521785259247,
0.06481804698705673,
-0.013846710324287415,
-0.040625933557748795,
-0.16477914154529572,
0.0025353068485856056,
0.05386650934815407,
-0.36687415838241577,
-0.26630744338035583,
0.18066340684890747,
-0.14301025867462158,
-0.08198833465576172,
0.12001000344753265,
0.08874032646417618,
0.1296103298664093,
-0.1086420863866806,
-0.09440317749977112,
-0.26291754841804504,
0.35357508063316345,
-0.06880894303321838,
-0.07171618193387985,
-0.5175827741622925,
0.17937538027763367,
0.04628625139594078,
0.04556059464812279,
-0.16146844625473022,
0.15518225729465485,
0.034261126071214676,
0.06900010257959366,
0.08457394689321518,
-0.09095524251461029,
0.010380751453340054,
0.000703447381965816,
0.0027592279948294163,
-0.0826510637998581,
-0.3547935485839844,
-0.23170369863510132,
0.15353058278560638,
-0.029270386323332787,
0.17821475863456726,
0.020234493538737297,
-0.19611582159996033,
0.061529383063316345,
0.04785908758640289,
-0.07346414774656296,
0.08163399994373322,
0.12859873473644257,
-0.09050166606903076,
0.12989787757396698,
-0.1553579866886139,
-0.3254355490207672,
-0.11900746822357178,
0.028699884191155434,
0.1146986111998558,
-0.06889650225639343,
-0.18354366719722748,
-0.1849789321422577,
0.15536698698997498,
-0.13629582524299622,
0.09524480253458023,
-0.001622773939743638,
-0.022452423349022865,
0.16286413371562958,
-0.01295916922390461,
0.10431301593780518,
0.03171510994434357,
-0.014721114188432693,
0.058184392750263214,
0.08937321603298187,
-0.13270360231399536,
0.22705239057540894,
0.09372342377901077,
0.1317756474018097,
-0.1363947093486786,
-0.06848268210887909,
0.14975017309188843,
0.026961585506796837,
-0.13386788964271545,
0.026070231571793556,
-0.026484370231628418,
0.1556597650051117,
0.14207510650157928,
-0.008709341287612915,
0.11781449615955353,
-0.1589152216911316,
-0.19773942232131958,
0.0018864404410123825,
0.013338059186935425,
-0.11016574501991272,
0.1659162938594818,
0.1893927901983261,
-0.02155395969748497,
-0.069492869079113,
-0.34373655915260315,
-0.015441878698766232,
-0.04739496856927872,
-0.10718017816543579,
-0.035057492554187775,
-0.04589993134140968,
0.15302583575248718,
0.31602561473846436,
0.054028283804655075,
0.10440415889024734,
0.06454335153102875,
0.009766953065991402,
-0.10153993219137192,
0.11922086775302887,
0.11117644608020782,
0.10444153845310211,
-0.11456531286239624,
0.2077050358057022,
-0.2149658203125,
0.042011406272649765,
-0.05999316647648811,
-0.0328008197247982,
0.20313888788223267,
-0.24330419301986694,
0.13893097639083862,
0.003962339833378792,
-0.07655317336320877,
-0.04708264395594597,
-0.008570646867156029,
-0.2869313359260559,
0.10834868252277374,
-0.23833008110523224,
-0.20685064792633057,
0.05702059343457222,
0.024920832365751266,
0.2002394050359726,
0.2623162865638733,
-0.07373186945915222,
-0.15615230798721313,
-0.16050010919570923,
0.035385604947805405,
-0.09065043181180954,
-0.05046447366476059,
0.051490459591150284,
-0.38071227073669434,
0.1550690233707428,
0.06532962620258331,
-0.015919402241706848,
-0.22468261420726776,
-0.12321095168590546,
0.05224497616291046,
-0.031787943094968796,
-0.0414312407374382,
-0.08083301037549973,
-0.2659046947956085,
0.048467621207237244,
0.13074685633182526,
-0.033121414482593536,
0.1742352843284607,
0.024272063747048378,
0.18595662713050842,
0.1325596570968628,
-0.048528894782066345,
0.22637014091014862,
0.013332441449165344,
-0.16840341687202454,
-0.2867453992366791,
-0.1392585039138794,
0.0032718689180910587,
0.08848262578248978,
-0.022730901837348938,
-0.04049937054514885,
0.07442813366651535,
0.01508844830095768,
-0.12456376850605011,
0.09898334741592407,
0.21564139425754547,
-0.4979762136936188,
-0.10104132443666458,
0.03896715119481087,
0.15444070100784302,
-0.12324418872594833,
-0.13745975494384766,
0.17168517410755157,
0.10621970891952515,
0.012624939903616905,
-0.01918209344148636,
0.02270359918475151,
0.12613293528556824,
0.1059659868478775,
0.1926196813583374,
0.16625674068927765,
0.21343453228473663,
0.08828508108854294,
-0.16116346418857574,
0.2424592673778534,
-0.19807268679141998,
0.01746772974729538,
0.07816453278064728,
-0.22793643176555634,
-0.02749571017920971,
-0.20256444811820984,
-0.1713997721672058,
-0.1394422948360443,
-0.03889493644237518,
0.12585391104221344,
0.13547773659229279,
0.14368553459644318,
0.003148505464196205,
0.000919151701964438,
-0.030007459223270416,
-0.029161613434553146,
-0.28897595405578613,
0.08468907326459885,
0.18928162753582,
-0.0006317566731013358,
0.08279724419116974,
-0.014621274545788765,
0.42633140087127686,
0.27780184149742126,
0.007166482508182526,
-0.01648191176354885,
-0.09653189778327942,
0.07700873911380768,
-0.2341468185186386,
0.03278724104166031,
-0.04421214014291763,
-0.06207527592778206,
0.17054758965969086,
0.11628774553537369,
-0.26179519295692444,
0.029302043840289116,
-0.10458242893218994,
0.09931481629610062,
-0.014411143958568573,
0.11142727732658386,
0.13335776329040527,
0.15263192355632782,
0.22284194827079773,
-0.10650509595870972,
0.02893764153122902,
-0.11149845272302628,
-0.03753269091248512,
0.1173441931605339,
-0.0013064778177067637,
0.03934571519494057,
0.17388667166233063,
-0.21266435086727142,
-0.27323779463768005,
-0.04899198189377785,
0.1985064297914505,
-0.09674583375453949,
-0.058428067713975906,
0.20257030427455902,
-0.2701912820339203,
-0.02475919760763645,
0.012118881568312645,
-0.10314720124006271,
0.028014423325657845,
0.07341521978378296,
-0.0906456932425499,
0.1314961165189743,
-0.07146960496902466,
0.003373577259480953,
0.0707932636141777,
0.008330175653100014,
-0.15991933643817902,
0.09628315269947052,
-0.14361152052879333,
-0.020548079162836075,
0.15355777740478516,
-0.09291529655456543,
-0.23428478837013245,
0.09175389260053635,
-0.16122964024543762,
0.059519510716199875,
0.06842595338821411,
0.020321644842624664,
0.02300671674311161,
-0.08830136805772781,
0.1388566642999649,
0.4526764452457428,
-0.17183513939380646,
-0.272065669298172,
-0.043858081102371216,
-0.1278500258922577,
0.11210698634386063,
-0.11520353704690933,
-0.04202429950237274,
-0.2566088140010834,
0.008320672437548637,
0.034727793186903,
0.04011751711368561,
-0.06651244312524796,
0.0952955111861229,
0.05680907890200615,
0.04592825099825859,
0.22749751806259155,
0.15705306828022003,
0.19243815541267395,
-0.01358537282794714,
-0.068662129342556,
0.07292749732732773,
-0.20302411913871765,
0.03132285177707672,
0.28317752480506897,
-0.027601860463619232,
-0.17253875732421875,
-0.01757541112601757,
-0.06267116963863373,
0.2932594120502472,
-0.08328559249639511,
0.23379294574260712,
-0.0960221216082573,
0.18078206479549408,
0.0875227078795433,
0.09837112575769424,
-0.0834222137928009,
0.1608782410621643,
-0.3242914080619812,
-0.06796467304229736,
-0.06995713710784912,
0.22734051942825317,
-0.03795564919710159,
0.030917009338736534,
-0.1682085543870926,
0.08116354793310165,
-0.008995947428047657,
0.0048567382618784904,
-0.16082583367824554,
-0.009304797276854515,
0.20836703479290009,
-0.1974506676197052,
0.12568247318267822,
0.0826161727309227,
0.1160496175289154,
0.16721564531326294,
0.14062798023223877,
0.03391588479280472,
-0.09146738797426224,
0.18084947764873505,
-0.12584714591503143,
0.058686140924692154,
-0.07411462813615799,
-0.1797046810388565,
-0.2457917481660843,
-0.12123983353376389,
-0.05943768844008446,
-0.20390541851520538,
-0.1580980122089386,
-0.15531852841377258,
0.08792832493782043,
-0.07454916834831238,
0.0964629128575325,
0.03839528188109398,
-0.1214723214507103,
-0.033257145434617996,
-0.12450975924730301,
0.036797478795051575,
-0.008400091901421547,
0.12220052629709244,
-0.10010583698749542,
-0.016954177990555763,
0.09680784493684769,
-0.14209045469760895,
-0.48656612634658813,
-0.12645238637924194,
0.13049466907978058,
-0.035460464656353,
-0.10401783138513565,
0.14766058325767517,
-0.13435354828834534,
0.22165043652057648,
0.03285308927297592,
0.01376594789326191,
0.29408302903175354,
0.31136876344680786,
-0.051324665546417236,
0.20659807324409485,
-0.14518597722053528,
0.03563137352466583,
-0.20864634215831757,
0.17655126750469208,
-0.16420108079910278,
0.13375890254974365,
-0.27956435084342957,
0.16927310824394226,
0.0014499984681606293,
0.15553991496562958,
0.10214070230722427,
-0.11641938239336014,
-0.21943485736846924,
-0.07915911078453064,
-0.022360466420650482,
0.2393217235803604,
-0.31458762288093567,
-0.24262292683124542,
-0.06578819453716278,
0.1622370034456253,
0.1716528683900833,
0.1697816401720047,
-0.12863413989543915,
0.043306831270456314,
-0.09037979692220688,
0.1663828343153,
-0.09077669680118561,
-0.10825998336076736,
-0.05107773467898369,
0.41184788942337036,
0.1287272870540619,
0.2166590541601181,
-0.15890046954154968,
-0.1354871690273285,
0.05707206204533577,
0.005636370740830898,
-0.11361410468816757,
0.05347064509987831,
-0.12037024646997452,
-0.00889444351196289,
0.20136834681034088,
0.05599310249090195,
0.10240603238344193,
-0.27703168988227844,
-0.10592794418334961,
0.03637470677495003,
0.12331612408161163,
-0.10197856277227402,
0.1512567400932312,
-0.2238892763853073,
0.2710399329662323,
-0.13773499429225922,
0.10982604324817657,
-0.15744343400001526,
0.08547249436378479,
-0.08550004661083221,
-0.2015957236289978,
0.004582654219120741,
-0.12939219176769257,
0.02013564296066761,
-0.0020493471529334784,
-0.30138665437698364,
0.2680804431438446,
0.38935428857803345,
-0.14927048981189728,
-0.13227999210357666,
0.021041497588157654,
0.0327802337706089,
-0.07487417012453079,
0.007031663320958614,
-0.06491107493638992,
0.14032036066055298,
0.09249252825975418,
-0.08979317545890808,
0.2583128809928894,
0.20089052617549896,
-0.024157099425792694,
-0.17444053292274475,
-0.031482014805078506,
-0.12679673731327057,
0.22936882078647614,
-0.08550349622964859,
0.1714007556438446,
0.24087415635585785,
0.14174789190292358,
-0.030109817162156105,
-0.009835993871092796,
-0.31461086869239807,
0.21863414347171783,
0.007956014946103096,
-0.32673779129981995,
-0.26760339736938477,
-0.10125909000635147,
0.0781615749001503,
0.023274386301636696,
0.03696015849709511,
-0.07340161502361298,
0.04255237430334091,
-0.3642105758190155,
0.15510712563991547,
0.03730746731162071,
0.11085816472768784,
0.1388547122478485,
-0.24094027280807495,
-0.09822097420692444,
0.36021995544433594,
-0.21885809302330017,
-0.25968873500823975,
-0.2549852728843689,
-0.2686537206172943,
0.13255809247493744,
0.06246960163116455,
0.22448042035102844,
-0.06731638312339783,
-0.26441091299057007,
0.14571703970432281,
-0.05534317344427109,
0.015896789729595184,
0.061049167066812515,
-0.23304802179336548,
0.01744471862912178,
-0.07663797587156296,
0.24818865954875946,
-0.20072034001350403,
0.36436671018600464,
0.004626031033694744,
0.14586645364761353,
-0.07452147454023361,
-0.28896260261535645,
0.08302727341651917,
0.10116449743509293,
-0.056429654359817505,
-0.10295386612415314,
-0.19766002893447876,
0.19689081609249115,
0.06352979689836502,
0.15555761754512787,
-0.10493682324886322,
-0.0658150166273117,
-0.22701922059059143,
-0.0968717411160469,
-0.4038296937942505,
0.019481513649225235,
-0.27548113465309143,
-0.13594123721122742,
-0.10794903337955475,
-0.2643684148788452,
-0.012669145129621029,
-0.06076642498373985,
-0.19191770255565643,
0.05065483972430229,
0.08664166927337646,
0.06017810106277466,
0.0005487514426931739,
0.16394196450710297,
0.17163154482841492,
-0.14996196329593658,
-0.006093316711485386,
-0.26647213101387024,
-0.06586166471242905,
0.020201193168759346,
0.14177291095256805,
0.07233608514070511,
-0.042454902082681656,
0.011726440861821175,
-0.17704623937606812,
-0.21123453974723816,
-0.03540627658367157,
-0.003671779064461589,
-0.3297587037086487,
0.010388972237706184,
-0.06392983347177505,
0.20318114757537842,
0.02768450789153576,
0.2555036246776581,
0.10465400665998459,
0.12906621396541595
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. Neuroleptic antiemetics (e.g., promethazine) can mask symptoms of progressive encephalopathy and are best avoided.Evaluation of relatives at risk: Testing of at-risk sibs of a patient is warranted to allow for early diagnosis and treatment.Genetic counseling.Propionic acidemia is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Carrier testing for at-risk relatives and prenatal testing for pregnancies at increased risk are possible if the pathogenic variants in the family are known.DiagnosisPropionic acidemia (PA) is caused by deficiency of the mitochondrial multimeric enzyme propionyl-CoA carboxylase that catalyzes the conversion of propionyl-CoA to D-methylmalonyl-CoA. The enzyme is composed of α- and β-subunits encoded by their respective genes, PCCA and PCC | [
-0.253214955329895,
0.10178476572036743,
0.026402147486805916,
-0.266092985868454,
0.1812872588634491,
0.038277436047792435,
0.05373873934149742,
-0.3139667212963104,
0.09493110328912735,
-0.053339868783950806,
0.3765157163143158,
0.13255669176578522,
-0.20358188450336456,
-0.06091612949967384,
-0.17840662598609924,
0.33005037903785706,
0.054045964032411575,
0.02847025915980339,
-0.03113541379570961,
-0.1335284411907196,
0.0006561549962498248,
-0.2611132264137268,
-0.0637127161026001,
-0.024267591536045074,
0.2523776590824127,
-0.11675365269184113,
0.15044862031936646,
-0.5139325261116028,
0.05653073638677597,
0.04927019029855728,
0.20782141387462616,
-0.09768740832805634,
0.30654940009117126,
-0.29315024614334106,
-0.12703344225883484,
-0.08424143493175507,
-0.13835708796977997,
-0.37376973032951355,
0.13853523135185242,
-0.231515571475029,
0.025421451777219772,
0.1600625067949295,
0.21365511417388916,
-0.1942846029996872,
0.1555812507867813,
-0.21058529615402222,
0.01702258735895157,
-0.29345470666885376,
0.05084088444709778,
0.2694433629512787,
0.2566641569137573,
-0.37626489996910095,
-0.3019455671310425,
-0.25358694791793823,
0.478828489780426,
-0.011948669329285622,
-0.09826570749282837,
-0.06843961775302887,
-0.33107349276542664,
0.17726288735866547,
-0.028847314417362213,
-0.270987868309021,
-0.10427170991897583,
-0.4013288617134094,
0.14756862819194794,
-0.022416986525058746,
-0.18142856657505035,
0.07097755372524261,
0.2734568119049072,
0.021119214594364166,
0.10108702629804611,
-0.008345365524291992,
-0.04419029876589775,
0.17189732193946838,
0.06006342172622681,
0.2497451901435852,
-0.05793179199099541,
-0.06847887486219406,
-0.17470486462116241,
-0.26629698276519775,
-0.15976785123348236,
0.035446081310510635,
-0.0441945418715477,
0.07884865999221802,
-0.2769305408000946,
-0.022069331258535385,
0.2601162791252136,
-0.0689045861363411,
-0.15873397886753082,
0.16326765716075897,
0.0965392142534256,
-0.03817790374159813,
0.22091689705848694,
0.05357827618718147,
0.19195152819156647,
-0.05188862606883049,
0.3402358889579773,
0.01613922044634819,
-0.14878202974796295,
0.06652817130088806,
0.0037456441204994917,
-0.13607008755207062,
-0.07677194476127625,
0.021124860271811485,
-0.10799587517976761,
0.06275905668735504,
-0.41009026765823364,
-0.1903492510318756,
0.022381139919161797,
0.1921461522579193,
0.4160913825035095,
-0.22418764233589172,
0.09961458295583725,
-0.010622723028063774,
-0.3485274612903595,
-0.02341325767338276,
-0.07511486858129501,
0.48671385645866394,
-0.05654250830411911,
0.3156418204307556,
0.032425571233034134,
0.09438035637140274,
0.2913462221622467,
0.054738402366638184,
-0.3612007796764374,
0.08634281903505325,
-0.05726877599954605,
-0.039694856852293015,
0.3136179447174072,
-0.040738772600889206,
0.14250151813030243,
-0.06717441976070404,
0.1667691022157669,
0.02501709945499897,
0.36650529503822327,
-0.10703910142183304,
-0.4457142651081085,
-0.17723612487316132,
0.013714034110307693,
0.06972107291221619,
0.10781095921993256,
0.18763713538646698,
0.2956305742263794,
0.24048645794391632,
0.2232024371623993,
0.03539251908659935,
0.40134817361831665,
-0.06153396889567375,
0.3692663609981537,
-0.04548395425081253,
0.2062777429819107,
-0.4404772222042084,
-0.1128297746181488,
0.003422063309699297,
-0.09798655658960342,
0.05244823545217514,
0.1017879992723465,
0.15239781141281128,
-0.11572705954313278,
-0.011119774542748928,
0.2630251348018646,
-0.10106553137302399,
-0.010088333860039711,
0.06940554082393646,
-0.08515014499425888,
-0.14442963898181915,
-0.4990646541118622,
0.016326291486620903,
0.1035459116101265,
-0.14899879693984985,
-0.1914675086736679,
-0.16929954290390015,
-0.0303523987531662,
0.060191184282302856,
0.04327709227800369,
0.19990520179271698,
-0.06460890173912048,
-0.08586864918470383,
-0.01567935012280941,
-0.014305239543318748,
0.08466620743274689,
-0.028087720274925232,
-0.08998772501945496,
-0.07349962741136551,
-0.002558006439357996,
-0.32123470306396484,
0.29396095871925354,
-0.01744973100721836,
0.001785685890354216,
0.2313762605190277,
0.2528637647628784,
0.02530750446021557,
0.20771285891532898,
0.15414175391197205,
-0.17999333143234253,
-0.12156776338815689,
0.17211121320724487,
0.13873454928398132,
-0.15864376723766327,
-0.03298019990324974,
0.0015417345566675067,
-0.09497562050819397,
0.20535072684288025,
-0.08283329755067825,
-0.10051991045475006,
-0.09777157008647919,
-0.08206108212471008,
-0.07126952707767487,
-0.06778496503829956,
0.034547824412584305,
-0.15057647228240967,
0.3150726854801178,
-0.17620912194252014,
-0.04769660532474518,
-0.291873961687088,
-0.06990282982587814,
-0.006999453064054251,
-0.15573184192180634,
-0.004556705709546804,
0.17949211597442627,
0.08513620495796204,
0.0512092299759388,
0.19065509736537933,
-0.33178913593292236,
-0.03565776348114014,
0.10796764492988586,
-0.42493936419487,
-0.4146236479282379,
0.31281760334968567,
-0.38300034403800964,
-0.043239694088697433,
0.06744525581598282,
0.031769417226314545,
0.11885905265808105,
-0.10263361781835556,
-0.18906129896640778,
-0.14989073574543,
0.3352046608924866,
0.018644263967871666,
0.07396488636732101,
-0.5276037454605103,
-0.005983932875096798,
0.04972946643829346,
0.22076073288917542,
0.0927763357758522,
0.3015802204608917,
-0.1674034744501114,
0.06906284391880035,
-0.10688239336013794,
-0.034506361931562424,
-0.23265448212623596,
0.09678737074136734,
-0.06724268198013306,
-0.03666796535253525,
-0.3147655725479126,
-0.34543412923812866,
0.2893701195716858,
0.04836511239409447,
0.019846124574542046,
0.013886354863643646,
0.035621121525764465,
0.2047671675682068,
-0.09201689809560776,
0.040652863681316376,
-0.021356800571084023,
0.06452146172523499,
-0.23418545722961426,
0.16979794204235077,
-0.1094939187169075,
-0.12612846493721008,
-0.044016752392053604,
0.18756526708602905,
0.10807494074106216,
0.2371828407049179,
-0.2912639379501343,
-0.2144133597612381,
0.06727100163698196,
0.12733913958072662,
0.08024108409881592,
0.10348294675350189,
-0.2382666915655136,
0.19474400579929352,
-0.14279070496559143,
0.2887384295463562,
0.35856321454048157,
0.11699144542217255,
-0.15975621342658997,
-0.0404386930167675,
-0.2406759262084961,
0.08290190249681473,
-0.041918572038412094,
0.10581981390714645,
-0.3510560095310211,
-0.06800059974193573,
0.19649779796600342,
0.18172766268253326,
-0.0760292261838913,
0.26724502444267273,
-0.02125738002359867,
0.12734442949295044,
-0.1977509707212448,
0.2713247239589691,
0.2587990164756775,
-0.28396835923194885,
-0.289020836353302,
0.12450088560581207,
0.005221738945692778,
-0.31879758834838867,
0.09153155982494354,
0.35794636607170105,
-0.19971796870231628,
-0.07638637721538544,
-0.4384402930736542,
0.07123565673828125,
-0.19960209727287292,
-0.18573832511901855,
0.20405060052871704,
0.022997446358203888,
0.329164981842041,
0.4855484962463379,
-0.26247522234916687,
0.017860209569334984,
-0.13558362424373627,
-0.056273143738508224,
-0.3063988983631134,
0.07934511452913284,
0.011703507974743843,
-0.0561063215136528,
0.05380849540233612,
0.056785110384225845,
0.037535663694143295,
0.3489374816417694,
0.0046064285561442375,
-0.20191019773483276,
0.43021687865257263,
-0.2095036804676056,
0.46619901061058044,
0.23193979263305664,
-0.035784926265478134,
0.01939544454216957,
0.12337546795606613,
-0.33625078201293945,
0.0191800594329834,
-0.130817711353302,
-0.1373409777879715,
0.16994284093379974,
-0.07661782205104828,
0.18414881825447083,
0.2786259651184082,
-0.07757928222417831,
-0.14895448088645935,
0.31373536586761475,
-0.16301238536834717,
-0.12563373148441315,
0.37827426195144653,
-0.21880917251110077,
-0.18647992610931396,
0.12027928233146667,
0.20115920901298523,
0.09098546206951141,
-0.29129305481910706,
0.02856232412159443,
0.23841260373592377,
-0.24210894107818604,
-0.006298929452896118,
-0.2792019844055176,
-0.07160249352455139,
0.07900290936231613,
0.1865975707769394,
0.15613096952438354,
0.07266052067279816,
0.3095339834690094,
0.3306846618652344,
0.192143052816391,
-0.08851154148578644,
0.14123307168483734,
-0.07348485291004181,
0.12115932255983353,
-0.3845970630645752,
-0.2982928156852722,
0.10186506807804108,
0.024160390719771385,
0.06700705736875534,
0.02146366983652115,
-0.1188364326953888,
0.15342353284358978,
0.2689821720123291,
0.2992423474788666,
0.11434771865606308,
-0.7083197832107544,
0.06647656112909317,
0.08657582104206085,
0.07400514930486679,
0.03162747621536255,
0.03345870226621628,
0.24408172070980072,
0.23260071873664856,
-0.06294094771146774,
-0.14006417989730835,
0.12294222414493561,
0.048547983169555664,
-0.10870335251092911,
0.10246095806360245,
0.13264085352420807,
0.22188767790794373,
0.060525838285684586,
-0.045633431524038315,
0.23929177224636078,
-0.26724180579185486,
0.05000971630215645,
0.10018856078386307,
-0.06959127634763718,
0.004826512653380632,
-0.2626892626285553,
-0.276432067155838,
-0.03187323734164238,
-0.18835268914699554,
-0.10698973387479782,
0.18470239639282227,
-0.07510904967784882,
-0.07099752128124237,
0.22800655663013458,
0.13740451633930206,
-0.2321859896183014,
-0.18326681852340698,
-0.16440312564373016,
0.11555222421884537,
-0.04179460182785988,
0.1763632446527481,
0.1154015064239502,
0.3193438649177551,
-0.14808127284049988,
-0.3418155312538147,
-0.17032931745052338,
-0.03674890473484993,
0.1840391606092453,
-0.39980822801589966,
0.10716942697763443,
-0.08555956929922104,
-0.10921123623847961,
0.23306326568126678,
0.3033265769481659,
-0.23029328882694244,
0.02241869457066059,
-0.16866567730903625,
0.3976983428001404,
0.30252566933631897,
0.33205127716064453,
-0.12254440039396286,
0.22001305222511292,
0.2536761462688446,
-0.30084729194641113,
-0.13528777658939362,
0.050472620874643326,
0.1601526439189911,
-0.1354932337999344,
0.0630999282002449,
0.12031814455986023,
0.027704045176506042,
-0.13793684542179108,
-0.23717908561229706,
0.23694993555545807,
0.4115578234195709,
-0.24622945487499237,
-0.09216724336147308,
-0.01313353143632412,
-0.20570743083953857,
-0.07794096320867538,
0.24085284769535065,
-0.003851688466966152,
0.15937893092632294,
0.005496980156749487,
-0.02815391682088375,
0.12508784234523773,
-0.29530805349349976,
0.17016386985778809,
-0.0674346387386322,
-0.11009100079536438,
0.09862861037254333,
0.12797968089580536,
-0.004275103099644184,
-0.2948053777217865,
-0.0024607409723103046,
-0.05866508185863495,
-0.2686053514480591,
0.06241530925035477,
-0.1615670919418335,
-0.14671841263771057,
0.38571250438690186,
0.0748317688703537,
0.09867513924837112,
0.07268506288528442,
0.13299605250358582,
0.314113587141037,
-0.07674276828765869,
-0.39698123931884766,
-0.044991686940193176,
-0.13364608585834503,
0.260076105594635,
0.1281985342502594,
-0.251505970954895,
-0.12150036543607712,
-0.06662050634622574,
0.29243582487106323,
-0.1486411690711975,
0.12943445146083832,
0.003959451802074909,
-0.2007005512714386,
-0.0668153241276741,
0.45130982995033264,
0.1847108155488968,
0.002144069178029895,
0.0887540727853775,
-0.11043225973844528,
0.05689603090286255,
-0.624442994594574,
0.16764910519123077,
0.33636316657066345,
-0.028216123580932617,
-0.431382417678833,
0.10534398257732391,
-0.09327869862318039,
0.2573738694190979,
-0.18611690402030945,
0.16140896081924438,
0.13593202829360962,
-0.08953531086444855,
0.3234686255455017,
0.16337311267852783,
-0.1869659721851349,
0.2863018214702606,
-0.24003595113754272,
-0.09398534893989563,
-0.07560618966817856,
0.2953231930732727,
-0.10611575841903687,
0.019565660506486893,
-0.1129245012998581,
-0.05737117677927017,
-0.04698406532406807,
-0.17929984629154205,
-0.16232046484947205,
-0.06074659526348114,
-0.2174454778432846,
-0.4147213399410248,
0.13190236687660217,
-0.04634149372577667,
0.05861091986298561,
0.10693559050559998,
-0.12076335400342941,
-0.06601523607969284,
-0.1616804152727127,
0.11563441157341003,
0.015472198836505413,
-0.0637441873550415,
0.06842143833637238,
-0.04753972962498665,
-0.1269952356815338,
-0.35668474435806274,
0.008212937042117119,
-0.08505993336439133,
-0.3015221059322357,
-0.26875996589660645,
-0.060403939336538315,
0.09761779755353928,
0.07585335522890091,
-0.06173353269696236,
-0.1344069093465805,
-0.01238214410841465,
-0.06703374534845352,
0.3023090064525604,
0.2212984263896942,
0.09623197466135025,
-0.19762156903743744,
-0.14086665213108063,
0.04009639844298363,
-0.2107952982187271,
-0.4276937246322632,
-0.008155208081007004,
0.15041962265968323,
-0.06401479244232178,
-0.251144677400589,
0.10934290289878845,
-0.16333173215389252,
0.07613171637058258,
0.06678979843854904,
0.06991494446992874,
0.10712882876396179,
0.33655911684036255,
-0.13212847709655762,
0.0723840519785881,
-0.1761556714773178,
0.08032187819480896,
-0.038640961050987244,
0.20397312939167023,
-0.3357539474964142,
0.31282931566238403,
-0.060328636318445206,
0.187055304646492,
0.007628318853676319,
0.11178241670131683,
0.3642966151237488,
-0.0393967479467392,
-0.07279670238494873,
0.16730743646621704,
0.01210541557520628,
0.24375233054161072,
-0.2830716669559479,
-0.0384172685444355,
-0.011707660742104053,
0.03508569672703743,
-0.05667358264327049,
-0.03415095433592796,
0.0472821481525898,
-0.21696826815605164,
-0.02803589403629303,
0.24323728680610657,
0.09308487921953201,
0.13692903518676758,
-0.015401259064674377,
0.5441156625747681,
0.1108652800321579,
0.11418338119983673,
-0.12136844545602798,
-0.19316965341567993,
0.2171291559934616,
0.03840911388397217,
-0.09161153435707092,
0.08137764036655426,
0.006500096991658211,
0.009915297850966454,
0.40615737438201904,
-0.07659270614385605,
0.1478966772556305,
-0.1260995864868164,
0.06416536122560501,
0.1805688589811325,
-0.08825192600488663,
-0.28563618659973145,
-0.026916425675153732,
-0.25616368651390076,
0.05063958093523979,
-0.12499299645423889,
0.2558486759662628,
-0.2486681193113327,
-0.07679572701454163,
-0.18864288926124573,
-0.13933177292346954,
-0.007974478416144848,
-0.19828090071678162,
0.1520153433084488,
-0.14987771213054657,
-0.11355936527252197,
0.3906534016132355,
0.24101996421813965,
-0.240861713886261,
0.007541542872786522,
-0.15701676905155182,
0.373637318611145,
-0.21326321363449097,
-0.19985441863536835,
0.0638936460018158,
0.4325612187385559,
-0.20061512291431427,
-0.20528817176818848,
0.36851197481155396,
0.19627314805984497,
0.19446834921836853,
-0.0844564214348793,
-0.37647658586502075,
-0.19722992181777954,
-0.06404659152030945,
0.10213062167167664,
0.3989117443561554,
0.1304868906736374,
-0.03210322931408882,
-0.22228458523750305,
0.15143248438835144,
-0.10923360288143158,
0.33265286684036255,
0.183950737118721,
-0.47856998443603516,
-0.24789422750473022,
0.036854349076747894,
0.05493507161736488,
0.12184121459722519,
-0.06333518028259277,
0.0009953291155397892,
0.21823878586292267,
-0.34118375182151794,
-0.030640345066785812,
-0.24203923344612122,
0.22679480910301208,
0.2638053596019745,
-0.04842584952712059,
0.2527298629283905,
0.3648228943347931,
-0.3154861629009247,
-0.18549810349941254,
-0.06604211032390594,
-0.08242931962013245,
0.1512310653924942,
0.1166612058877945,
0.4325481355190277,
-0.18087238073349,
-0.3983907103538513,
0.04998069629073143,
-0.10868265479803085,
0.16646559536457062,
-0.006005989387631416,
-0.15617702901363373,
-0.08027934283018112,
-0.2761930227279663,
0.204828143119812,
-0.20178008079528809,
0.10554716736078262,
-0.21762022376060486,
0.15204179286956787,
-0.1417083591222763,
-0.20448757708072662,
-0.15730354189872742,
0.1226639524102211,
0.151809424161911,
-0.1966608613729477,
0.05049239844083786,
0.2744123935699463,
-0.0967673659324646,
-0.002616617828607559,
0.14060372114181519,
-0.07540195435285568,
-0.159085214138031,
-0.0034014128614217043,
-0.5911179184913635,
0.21356207132339478,
-0.2071877419948578,
0.1921655535697937,
-0.015578754246234894,
0.19969473779201508,
0.02972818724811077,
-0.2780712842941284,
-0.2958318889141083,
0.12976855039596558,
0.06469478458166122,
-0.3152216076850891,
-0.06661838293075562,
0.17562700808048248,
0.09920211881399155,
-0.1119116023182869,
0.013879389502108097,
-0.022837486118078232,
-0.13271471858024597,
0.03577360883355141,
0.03162285313010216,
0.07006320357322693,
-0.05430518463253975,
0.1115615963935852,
0.013674640096724033,
-0.3929542005062103,
-0.026144083589315414,
-0.023588063195347786,
-0.13526161015033722,
0.1234457790851593,
-0.023249033838510513,
0.21106378734111786,
-0.12027577310800552,
0.19452506303787231,
0.09297467023134232,
0.15588843822479248
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. 25% chance of being unaffected and not a carrier. Carrier testing for at-risk relatives and prenatal testing for pregnancies at increased risk are possible if the pathogenic variants in the family are known.DiagnosisPropionic acidemia (PA) is caused by deficiency of the mitochondrial multimeric enzyme propionyl-CoA carboxylase that catalyzes the conversion of propionyl-CoA to D-methylmalonyl-CoA. The enzyme is composed of α- and β-subunits encoded by their respective genes, PCCA and PCCB. Deficient activity of propionyl-CoA carboxylase results in accumulation of propionic acid and propionyl-CoA related metabolites, which can be detected biochemically. In many countries, infants at risk for PA can be detected via newborn screening (NBS), although symptoms may be evident in the infant before NBS results are available. Clinical manifestations of PA are often nonspecific and age of onset is variable.Suggestive FindingsPropionic acidemia (PA) should be suspected in individuals with any of | [
-0.23109140992164612,
0.022456523030996323,
0.06303940713405609,
-0.2588367760181427,
0.32809320092201233,
-0.06300493329763412,
-0.02836349606513977,
-0.3682266175746918,
0.2226022481918335,
-0.20167145133018494,
0.3857969343662262,
0.061530474573373795,
-0.19360029697418213,
0.022960949689149857,
-0.3364911377429962,
0.3409852683544159,
0.20309071242809296,
-0.05054967850446701,
-0.08266749233007431,
-0.1645677238702774,
-0.1655525416135788,
-0.2841823995113373,
-0.017685694620013237,
0.02123641036450863,
0.3251051902770996,
-0.12012825906276703,
0.10437782108783722,
-0.5026608109474182,
0.14740805327892303,
0.046678632497787476,
0.146520733833313,
-0.1724516749382019,
0.15838722884655,
-0.12450224906206131,
-0.022102052345871925,
-0.20601610839366913,
-0.04265006631612778,
-0.41963982582092285,
0.13237535953521729,
-0.1268473118543625,
0.062173858284950256,
0.1757471114397049,
0.3946276307106018,
-0.24150602519512177,
0.18452495336532593,
-0.1091611385345459,
0.006716382224112749,
-0.21706023812294006,
0.029414646327495575,
0.19795995950698853,
0.48668280243873596,
-0.32222914695739746,
-0.31252720952033997,
-0.20582875609397888,
0.24889837205410004,
-0.057418093085289,
-0.2563961148262024,
-0.10077555477619171,
-0.2550857961177826,
0.3079371750354767,
0.06074877828359604,
-0.16318823397159576,
-0.2066670060157776,
-0.29254430532455444,
0.043506067246198654,
-0.14119645953178406,
0.0023064478300511837,
0.11558645218610764,
0.09045615047216415,
0.023938102647662163,
0.07921921461820602,
0.026887178421020508,
0.01816878654062748,
0.17662321031093597,
0.04947179928421974,
0.1384122669696808,
-0.05528802424669266,
-0.028716716915369034,
-0.01255987212061882,
-0.08397527784109116,
-0.26275384426116943,
0.12537449598312378,
-0.04464375972747803,
-0.13018596172332764,
-0.37982016801834106,
0.0985204204916954,
0.27347332239151,
-0.037745457142591476,
-0.2520570158958435,
0.23523052036762238,
0.18934012949466705,
-0.07904192060232162,
0.2309674769639969,
0.08815532177686691,
0.01694280281662941,
-0.26457762718200684,
0.44542622566223145,
0.13750305771827698,
-0.20140983164310455,
0.043152645230293274,
0.16229310631752014,
-0.08902037143707275,
-0.007806058973073959,
-0.04452754184603691,
-0.3703668713569641,
-0.028081465512514114,
-0.292181134223938,
-0.15580305457115173,
-0.09780872613191605,
0.00570390559732914,
0.28292515873908997,
-0.23684316873550415,
0.18098534643650055,
0.21191458404064178,
-0.4987175762653351,
0.04425005242228508,
-0.061261385679244995,
0.3766421377658844,
-0.020613113418221474,
0.3190155625343323,
-0.13592205941677094,
0.0974210873246193,
0.15253785252571106,
0.209929957985878,
-0.24742355942726135,
0.1639357954263687,
-0.0640130266547203,
-0.058335788547992706,
0.3808494210243225,
0.007876765914261341,
0.08517622202634811,
-0.008835910819470882,
0.048289988189935684,
-0.12224412709474564,
0.27317193150520325,
0.010855892673134804,
-0.5220392942428589,
-0.26751768589019775,
0.2400738000869751,
0.16916483640670776,
0.2128215879201889,
0.0764784961938858,
0.37043264508247375,
0.26580023765563965,
0.27301549911499023,
0.11107521504163742,
0.4121524393558502,
-0.18901169300079346,
0.31775423884391785,
-0.14072293043136597,
0.012359811924397945,
-0.5207051038742065,
-0.09505346417427063,
0.014811587519943714,
-0.11677934229373932,
0.28047865629196167,
0.007736379746347666,
0.12702211737632751,
-0.13190355896949768,
-0.10943110287189484,
0.3399241268634796,
-0.06111718714237213,
-0.14910465478897095,
0.0016277951654046774,
-0.04308127984404564,
-0.10581961274147034,
-0.4195514917373657,
0.007647799793630838,
0.18816035985946655,
-0.018458358943462372,
-0.18541164696216583,
-0.13406340777873993,
-0.08698432147502899,
0.14706914126873016,
0.056003227829933167,
-0.015910539776086807,
-0.2562447488307953,
-0.156060591340065,
0.02292587421834469,
0.0626140609383583,
0.11415581405162811,
0.10140224546194077,
-0.35248446464538574,
0.04643120616674423,
0.05801166966557503,
-0.3021449148654938,
0.04786887392401695,
-0.0717884972691536,
0.0699441060423851,
0.0793650820851326,
0.034458938986063004,
0.06466928124427795,
0.2575336992740631,
0.22859328985214233,
-0.06003853678703308,
-0.15075266361236572,
0.238907128572464,
0.19920718669891357,
-0.25133925676345825,
0.09990891069173813,
0.08680238574743271,
-0.10988310724496841,
0.10426467657089233,
-0.06388310343027115,
-0.2727222144603729,
0.032468874007463455,
-0.16321107745170593,
-0.13925792276859283,
-0.15550589561462402,
0.08719679713249207,
-0.2087412029504776,
0.30447691679000854,
-0.2690083682537079,
-0.06916090846061707,
-0.13694556057453156,
0.025084709748625755,
0.02646593376994133,
-0.12918482720851898,
0.03899163752794266,
0.3923189640045166,
0.24960695207118988,
0.08873850107192993,
0.2714182436466217,
-0.3624565601348877,
-0.13188661634922028,
0.05145714804530144,
-0.3567587435245514,
-0.3818049132823944,
0.21699422597885132,
-0.27411893010139465,
-0.13988468050956726,
0.06323563307523727,
0.125641867518425,
0.25670021772384644,
0.013774600811302662,
-0.24287649989128113,
-0.12456151098012924,
0.31451863050460815,
-0.0014615999534726143,
0.10346537828445435,
-0.4354798197746277,
-0.06467792391777039,
0.09837780147790909,
0.2746308743953705,
-0.0007461801869794726,
0.2522618770599365,
-0.03285164386034012,
0.14293935894966125,
-0.08550866693258286,
-0.027893904596567154,
-0.24057510495185852,
0.2124616503715515,
-0.039521630853414536,
-0.029858505353331566,
-0.3672356903553009,
-0.2901388108730316,
0.20941293239593506,
0.08076755702495575,
-0.022479254752397537,
-0.108524851500988,
0.058211516588926315,
0.25395187735557556,
-0.08029700070619583,
0.019390065222978592,
0.0034384524915367365,
0.049313466995954514,
-0.22283780574798584,
0.1122494637966156,
-0.13047564029693604,
-0.08979123830795288,
0.05765557661652565,
0.30912110209465027,
0.09641564637422562,
0.2670068144798279,
-0.2862924337387085,
-0.14621667563915253,
0.11880771070718765,
0.23974794149398804,
0.047101397067308426,
0.1287500560283661,
-0.2516288459300995,
0.3317532241344452,
-0.28758418560028076,
0.23473267257213593,
0.2192232757806778,
0.14331930875778198,
-0.10716724395751953,
-0.09847664833068848,
-0.3296229839324951,
0.1915847808122635,
-0.06815528869628906,
0.14106020331382751,
-0.2743564546108246,
-0.1711861491203308,
0.13152697682380676,
0.12775106728076935,
0.011602470651268959,
0.11808349192142487,
-0.0710904523730278,
0.12657183408737183,
-0.23489679396152496,
0.2797277271747589,
0.28621330857276917,
-0.3322637379169464,
-0.2921309471130371,
0.3963722288608551,
-0.16296793520450592,
-0.3314223885536194,
-0.030043650418519974,
0.41813895106315613,
-0.2279273122549057,
-0.19185064733028412,
-0.3042122423648834,
0.06538175791501999,
-0.13119229674339294,
-0.047196246683597565,
0.43681830167770386,
-0.0076969461515545845,
0.36991527676582336,
0.4155103862285614,
-0.0854208692908287,
-0.13073015213012695,
0.03114481456577778,
-0.10739458352327347,
-0.30226948857307434,
0.07375244796276093,
-0.11427967250347137,
0.10710609704256058,
0.08903257548809052,
-0.3307555913925171,
0.13510923087596893,
0.3634282648563385,
0.036922387778759,
-0.1813943088054657,
0.5426046252250671,
-0.089637890458107,
0.5655022263526917,
0.21467263996601105,
-0.06118790805339813,
-0.05221576616168022,
0.24698562920093536,
-0.21333110332489014,
-0.07542729377746582,
-0.2339077889919281,
-0.12957815825939178,
0.23890554904937744,
0.017767691984772682,
0.25159597396850586,
0.10302825272083282,
-0.15739481151103973,
-0.10765796899795532,
0.2568396031856537,
-0.11172284185886383,
-0.2159789651632309,
0.47999489307403564,
-0.10594406723976135,
-0.28762495517730713,
0.19136931002140045,
0.2848770320415497,
0.047576263546943665,
-0.2050134241580963,
-0.03029443509876728,
0.3537657856941223,
-0.20674003660678864,
0.0534345805644989,
-0.2587868571281433,
0.0299693513661623,
0.10032748430967331,
0.1931954026222229,
0.3722280263900757,
0.06158176437020302,
0.27842095494270325,
0.19604066014289856,
0.241330087184906,
-0.09327626973390579,
0.2060929238796234,
-0.21975913643836975,
0.04983590170741081,
-0.15841588377952576,
-0.14972427487373352,
0.06256099045276642,
-0.05389469489455223,
0.020399922505021095,
0.0588933601975441,
0.0061486405320465565,
0.19495423138141632,
0.1960620880126953,
0.3249151408672333,
0.08514074981212616,
-0.5807211995124817,
0.026745056733489037,
0.2053120881319046,
0.09162637591362,
0.039416953921318054,
-0.004762724041938782,
0.14748981595039368,
0.15697835385799408,
0.14900292456150055,
-0.2899942100048065,
0.1961119920015335,
0.08047453314065933,
-0.22970551252365112,
0.09240533411502838,
0.13137175142765045,
0.031233005225658417,
0.061424948275089264,
0.12368807941675186,
0.2210029661655426,
-0.16911408305168152,
0.030019676312804222,
-0.001529057277366519,
0.03539929538965225,
-0.02291988767683506,
-0.08395308256149292,
-0.26999253034591675,
-0.23370711505413055,
-0.14025360345840454,
0.027142126113176346,
0.2798904478549957,
-0.07133182138204575,
-0.14814969897270203,
0.2838098704814911,
0.28665125370025635,
-0.15533724427223206,
-0.2930854558944702,
-0.23879624903202057,
0.0988253802061081,
-0.10760663449764252,
0.24206390976905823,
0.0375584177672863,
0.25712600350379944,
-0.21948136389255524,
-0.2589510381221771,
-0.07606779783964157,
0.106006920337677,
0.12349463254213333,
-0.47457602620124817,
0.12327824532985687,
-0.015677649527788162,
-0.22630782425403595,
0.2828097641468048,
0.24220384657382965,
-0.10948333144187927,
-0.007294913288205862,
-0.2157226800918579,
0.4355405271053314,
0.45930349826812744,
0.35546237230300903,
0.027498304843902588,
0.21263286471366882,
0.19453853368759155,
-0.24927447736263275,
-0.04105006158351898,
-0.0196977611631155,
0.09768509864807129,
-0.06538167595863342,
0.041123297065496445,
-0.0664839893579483,
0.10050541162490845,
-0.3492615818977356,
-0.23389621078968048,
0.1706608533859253,
0.3202657699584961,
-0.14184948801994324,
0.03544740378856659,
0.10735217481851578,
-0.2703416347503662,
-0.05012162774801254,
0.15512457489967346,
-0.12681026756763458,
0.2535113990306854,
0.14276118576526642,
-0.13815699517726898,
0.06720823049545288,
-0.5139002203941345,
0.2425614297389984,
-0.2935623526573181,
-0.18711745738983154,
0.1482841819524765,
0.16257818043231964,
0.01832544431090355,
-0.3546326756477356,
-0.1321912556886673,
-0.16691717505455017,
-0.21598875522613525,
0.13165435194969177,
-0.14942608773708344,
-0.3719179928302765,
0.2644948363304138,
0.12377084046602249,
0.014014465734362602,
0.10619661211967468,
0.06577757745981216,
0.378919780254364,
-0.06937716156244278,
-0.2321215569972992,
0.17139200866222382,
-0.17808444797992706,
0.2955661118030548,
0.09059865772724152,
-0.37353160977363586,
-0.24360598623752594,
-0.2261611372232437,
0.34030863642692566,
0.06887044757604599,
0.17344968020915985,
-0.06785314530134201,
-0.21989214420318604,
-0.06374581158161163,
0.5465020537376404,
0.05595497041940689,
-0.015423351898789406,
0.16346020996570587,
-0.07156915217638016,
0.008135652169585228,
-0.5530295968055725,
0.24298539757728577,
0.4157589375972748,
-0.10925629734992981,
-0.42295345664024353,
0.09642446041107178,
-0.1548987776041031,
0.21211576461791992,
-0.16340793669223785,
0.1948510855436325,
0.017180489376187325,
0.056245867162942886,
0.23743027448654175,
0.1694861650466919,
-0.16972798109054565,
0.1792437732219696,
-0.04737551882863045,
-0.14858055114746094,
-0.16431115567684174,
0.38896238803863525,
-0.09035617858171463,
0.003812267445027828,
-0.18058650195598602,
-0.04007108882069588,
-0.03190324455499649,
-0.20213505625724792,
-0.14953842759132385,
0.06690917164087296,
-0.12879620492458344,
-0.4853416383266449,
-0.007276677060872316,
0.047546688467264175,
0.08495841920375824,
0.12583613395690918,
-0.18179082870483398,
-0.16584086418151855,
-0.12439966201782227,
0.07927902042865753,
0.06741027534008026,
0.017664695158600807,
0.03594199940562248,
-0.012533724308013916,
-0.11593469232320786,
-0.5274671912193298,
-0.05879232659935951,
-0.026305846869945526,
-0.11817197501659393,
-0.3039570152759552,
0.03002840466797352,
0.023861965164542198,
0.24807208776474,
-0.20156875252723694,
-0.017529815435409546,
-0.03167539834976196,
-0.13586480915546417,
0.4124113917350769,
0.10763365030288696,
0.21517802774906158,
-0.21641376614570618,
-0.0847291648387909,
0.036066316068172455,
-0.03427606448531151,
-0.42923203110694885,
0.04812178015708923,
0.23089444637298584,
-0.19071081280708313,
-0.26997169852256775,
0.2240457832813263,
-0.25139665603637695,
0.17462269961833954,
-0.06375592947006226,
0.23171384632587433,
0.06269814074039459,
0.3511629104614258,
-0.14515703916549683,
0.0338408537209034,
-0.21310093998908997,
-0.01113385334610939,
0.05963132530450821,
0.2996760904788971,
-0.3632063567638397,
0.26310423016548157,
-0.18523718416690826,
0.08232231438159943,
0.01922309584915638,
0.26698121428489685,
0.5198700428009033,
-0.06944283843040466,
-0.10513605177402496,
0.2054683268070221,
0.24104279279708862,
0.1385679692029953,
-0.3380398750305176,
0.050035372376441956,
0.07328618317842484,
0.07195932418107986,
0.03889352083206177,
0.011399681679904461,
-0.020198551937937737,
-0.1833583563566208,
-0.11885092407464981,
0.3022461533546448,
0.2426043152809143,
0.23286058008670807,
0.06047269329428673,
0.40888696908950806,
0.09004627168178558,
0.13159166276454926,
-0.15165403485298157,
-0.24713006615638733,
0.1474607288837433,
0.10370159894227982,
0.06325609236955643,
0.06645625829696655,
0.05530115216970444,
0.20845170319080353,
0.3542572557926178,
-0.18447919189929962,
0.1754050850868225,
-0.225533127784729,
0.11906087398529053,
0.2316831350326538,
0.028515631332993507,
-0.36470848321914673,
0.019109506160020828,
-0.16347277164459229,
0.11766880005598068,
-0.22557538747787476,
0.07418081164360046,
-0.31979671120643616,
0.060418762266635895,
-0.14303651452064514,
-0.12650607526302338,
-0.15415772795677185,
-0.12108910828828812,
0.16008494794368744,
-0.214076966047287,
-0.005410764832049608,
0.2764805853366852,
0.2655459940433502,
-0.14886441826820374,
-0.026064103469252586,
-0.02360028214752674,
0.43121615052223206,
-0.4295060932636261,
-0.17708952724933624,
0.11515640467405319,
0.31014057993888855,
-0.2154649794101715,
-0.19275763630867004,
0.3787391781806946,
0.2535257041454315,
0.14977887272834778,
-0.006038227584213018,
-0.37693434953689575,
-0.11943084746599197,
-0.09042767435312271,
-0.09959069639444351,
0.41670551896095276,
0.04686598479747772,
-0.18517620861530304,
-0.3129078149795532,
0.089512899518013,
0.07206092774868011,
0.4692552387714386,
0.4386199712753296,
-0.489847332239151,
-0.217023566365242,
-0.006593651603907347,
0.06907956302165985,
0.002270117402076721,
-0.004799793008714914,
0.12991362810134888,
0.27254733443260193,
-0.27718308568000793,
-0.05678257346153259,
-0.17169450223445892,
0.3508734107017517,
0.33874574303627014,
0.16594520211219788,
0.19870087504386902,
0.4809057116508484,
-0.423194020986557,
-0.19843707978725433,
0.05130092427134514,
-0.0682222917675972,
0.1559194028377533,
0.2041885405778885,
0.3934483528137207,
-0.27058225870132446,
-0.3540922701358795,
0.02192929945886135,
-0.10917080193758011,
0.16404354572296143,
0.013058655895292759,
-0.24672488868236542,
-0.2864602208137512,
-0.2940182387828827,
0.24957092106342316,
-0.27680307626724243,
0.04931621626019478,
-0.18125109374523163,
0.09344460070133209,
-0.1350793093442917,
-0.11831584572792053,
-0.17916250228881836,
0.27945590019226074,
0.0701812282204628,
-0.13232697546482086,
0.015429975464940071,
0.19632285833358765,
-0.24493920803070068,
0.13001741468906403,
0.036815665662288666,
-0.1849716305732727,
-0.23481062054634094,
-0.009456116706132889,
-0.4688589572906494,
0.08591249585151672,
-0.08935976028442383,
0.17074254155158997,
0.06515056639909744,
0.29175087809562683,
-0.09174112230539322,
-0.3993230164051056,
-0.0719592273235321,
0.10153346508741379,
0.1013156846165657,
-0.31231194734573364,
-0.03256935998797417,
0.1974254995584488,
-0.04613593593239784,
-0.2424958050251007,
0.014043922536075115,
-0.022573795169591904,
-0.2129257619380951,
0.1817665696144104,
0.05139538273215294,
0.09064972400665283,
0.0374259427189827,
0.11485005170106888,
0.004970846697688103,
-0.3701522946357727,
0.056673090904951096,
-0.08887381851673126,
-0.16252978146076202,
0.08926315605640411,
0.14787188172340393,
0.023790515959262848,
-0.027710599824786186,
0.1673717349767685,
-0.00012998229067306966,
0.1489197015762329
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. genes, PCCA and PCCB. Deficient activity of propionyl-CoA carboxylase results in accumulation of propionic acid and propionyl-CoA related metabolites, which can be detected biochemically. In many countries, infants at risk for PA can be detected via newborn screening (NBS), although symptoms may be evident in the infant before NBS results are available. Clinical manifestations of PA are often nonspecific and age of onset is variable.Suggestive FindingsPropionic acidemia (PA) should be suspected in individuals with any of the following presentations.Neonatal-onset propionic acidemia (PA) is the most common clinical form of PA. In the first few days of life, infants present with:LethargyPoor feedingVomitingHypotoniaWithout treatment, this can progress to encephalopathy and cardiorespiratory failure.Symptoms may be evident in the infant before NBS results are available.Late-onset PA can present with a variety of concerns including:Developmental delayIntellectual disabilityFailure | [
-0.14206363260746002,
0.07268442213535309,
-0.07698781043291092,
-0.2421204000711441,
0.12331002205610275,
-0.04720865935087204,
-0.13892465829849243,
-0.17762085795402527,
-0.05348769202828407,
-0.2316889762878418,
0.2141314148902893,
-0.008837290108203888,
-0.12937109172344208,
0.16621729731559753,
-0.2443964183330536,
0.21096482872962952,
0.1666354387998581,
-0.07356353104114532,
-0.11326667666435242,
-0.19410212337970734,
0.06510911136865616,
-0.3571346402168274,
-0.10145250707864761,
0.04512741416692734,
0.3490051031112671,
-0.11594020575284958,
0.2121657282114029,
-0.39174243807792664,
0.37831172347068787,
0.26540127396583557,
0.18383033573627472,
0.1715371310710907,
0.14118018746376038,
-0.3901313543319702,
0.06388430297374725,
-0.15543659031391144,
0.09083934873342514,
-0.2698964774608612,
-0.037523847073316574,
-0.3435667157173157,
0.21827197074890137,
-0.017098072916269302,
0.2325834035873413,
-0.1326580047607422,
0.1694120615720749,
0.03242354094982147,
-0.12445816397666931,
-0.06535940617322922,
-0.07421769946813583,
0.29006412625312805,
0.3877059519290924,
-0.10112174600362778,
-0.35020074248313904,
-0.014314671978354454,
0.07544812560081482,
-0.14243382215499878,
-0.17064733803272247,
-0.05925453454256058,
-0.18884602189064026,
0.21965479850769043,
0.04978274554014206,
-0.38354188203811646,
-0.15946348011493683,
-0.17594777047634125,
0.12094162404537201,
-0.14496828615665436,
-0.028468478471040726,
0.040493182837963104,
0.1578512042760849,
-0.24225035309791565,
-0.005337300710380077,
0.043474506586790085,
-0.21231044828891754,
0.07063669711351395,
-0.09800543636083603,
0.00637921504676342,
0.02116622030735016,
0.15229783952236176,
-0.16376665234565735,
-0.3258633315563202,
-0.2736382484436035,
0.1074434369802475,
-0.00794643722474575,
-0.2213096022605896,
-0.20729944109916687,
0.07552605122327805,
0.3540804386138916,
-0.01742587611079216,
-0.09134740382432938,
0.4450676739215851,
0.21205510199069977,
-0.18940187990665436,
0.008842268958687782,
-0.0764879584312439,
0.053531404584646225,
-0.17623178660869598,
0.2011004090309143,
0.10052162408828735,
-0.18462695181369781,
0.0682644173502922,
-0.07521073520183563,
0.0036529554054141045,
-0.14266598224639893,
0.04877840355038643,
-0.17437434196472168,
0.11310722678899765,
-0.11652354896068573,
-0.17178475856781006,
0.005789433605968952,
0.05533153936266899,
0.16090258955955505,
-0.35771873593330383,
0.18611373007297516,
-0.0002208889927715063,
-0.5287454724311829,
0.06565362215042114,
-0.17231985926628113,
0.20703063905239105,
-0.06591641902923584,
0.18343234062194824,
-0.04497084021568298,
0.0391073040664196,
0.0351792573928833,
0.012728951871395111,
-0.1684620976448059,
0.20481985807418823,
0.00487497029826045,
0.1336842030286789,
0.22951562702655792,
0.009343844838440418,
0.031025558710098267,
-0.05040619149804115,
0.13016562163829803,
-0.12852399051189423,
0.3624308407306671,
0.03111410327255726,
-0.39229997992515564,
-0.33768752217292786,
0.03847115486860275,
-0.05426531657576561,
0.07980020344257355,
0.37573057413101196,
0.3668053150177002,
0.1824943572282791,
0.29834815859794617,
0.10272087901830673,
0.45705366134643555,
-0.1464279443025589,
0.3710840344429016,
0.010534458793699741,
-0.2470993995666504,
-0.29521146416664124,
0.1769075095653534,
-0.033404361456632614,
-0.10242271423339844,
0.31844910979270935,
-0.007346516940742731,
0.10579993575811386,
-0.14745907485485077,
0.04752342775464058,
-0.04340440407395363,
-0.042131438851356506,
-0.05398137867450714,
-0.05615923926234245,
0.0376429483294487,
0.03677882254123688,
-0.5841758251190186,
-0.09198515862226486,
-0.058047350496053696,
0.034135688096284866,
-0.040086884051561356,
-0.0986563041806221,
0.033669061958789825,
0.13331221044063568,
0.02998584322631359,
0.0007863178616389632,
-0.21411743760108948,
-0.20431119203567505,
0.05806499347090721,
0.2072904258966446,
0.1804816871881485,
0.0785360261797905,
-0.22001011669635773,
0.09747343510389328,
-0.14497539401054382,
-0.1722751408815384,
0.03637999668717384,
0.11640899628400803,
-0.05017457902431488,
0.17661580443382263,
0.07044518738985062,
0.12655889987945557,
0.10934656858444214,
0.22808286547660828,
0.029880451038479805,
-0.2902885675430298,
0.27780210971832275,
0.12651775777339935,
-0.14830537140369415,
-0.0070632100105285645,
-0.20521515607833862,
-0.11460385471582413,
0.176400825381279,
-0.12235020846128464,
-0.06482630223035812,
-0.2575788199901581,
-0.007739267777651548,
-0.1633518934249878,
0.03794429451227188,
0.09540672600269318,
-0.0948723554611206,
0.3653835356235504,
-0.22341443598270416,
-0.08257903903722763,
-0.2965152859687805,
-0.033379845321178436,
0.12892620265483856,
-0.1784266084432602,
-0.03786946088075638,
0.22176435589790344,
0.059240952134132385,
0.059924185276031494,
-0.0023955421056598425,
-0.2526453733444214,
0.04747399315237999,
0.02751045487821102,
-0.3880012035369873,
-0.2113942950963974,
0.21550381183624268,
-0.4159099757671356,
-0.092460498213768,
0.06377723067998886,
0.0030166716314852238,
0.29267218708992004,
0.02173379249870777,
-0.15511825680732727,
-0.13852450251579285,
0.514595627784729,
-0.2912520468235016,
-0.073355533182621,
-0.522958517074585,
-0.2510429322719574,
0.005044406279921532,
0.14469574391841888,
-0.07396718114614487,
0.08634376525878906,
-0.05833897367119789,
0.17715173959732056,
0.08171914517879486,
0.0023214328102767467,
-0.10188820213079453,
0.19814381003379822,
-0.11764218658208847,
0.08443837612867355,
-0.42910727858543396,
-0.21347332000732422,
0.1667606383562088,
0.11546078324317932,
0.1521407961845398,
-0.030504494905471802,
-0.018056664615869522,
0.36318743228912354,
0.03796198219060898,
0.04054354131221771,
0.1126890629529953,
-0.15048718452453613,
-0.27009373903274536,
0.25968730449676514,
0.05043727904558182,
-0.22417035698890686,
-0.0663021132349968,
0.20658500492572784,
0.06585513055324554,
0.2932285666465759,
-0.2946307063102722,
-0.27013063430786133,
0.050151728093624115,
0.16526302695274353,
-0.0866377130150795,
-0.050090305507183075,
-0.1521981954574585,
0.4329894483089447,
0.009262881241738796,
0.06975237280130386,
0.08922290802001953,
0.19300037622451782,
-0.0879003182053566,
-0.008622185327112675,
-0.057848457247018814,
0.06938803195953369,
-0.01628141663968563,
0.045584939420223236,
-0.27248355746269226,
-0.09478349983692169,
0.2550687789916992,
0.32842135429382324,
0.011268793605268002,
0.0794529989361763,
-0.02903793938457966,
0.13045625388622284,
0.034715328365564346,
0.05564258247613907,
0.3707089424133301,
-0.15973103046417236,
-0.19417184591293335,
0.10419633239507675,
-0.15206073224544525,
-0.216266930103302,
0.19842754304409027,
0.2606278359889984,
-0.12026771157979965,
-0.16365063190460205,
-0.16595962643623352,
0.09608293324708939,
-0.013283138163387775,
-0.09677668660879135,
0.1490618735551834,
0.0936918556690216,
0.16817474365234375,
0.26589781045913696,
-0.16153785586357117,
-0.12497863173484802,
0.022850120440125465,
0.019156090915203094,
-0.33112263679504395,
-0.11752279847860336,
0.1155778095126152,
-0.20837438106536865,
0.006889449432492256,
-0.003921942785382271,
-0.06582987308502197,
0.22685639560222626,
0.006827977020293474,
-0.27557477355003357,
0.43293845653533936,
-0.13206204771995544,
0.24526792764663696,
0.04727921634912491,
-0.046377379447221756,
0.2328716218471527,
0.1750679463148117,
-0.2578568160533905,
0.06780526041984558,
-0.24957525730133057,
-0.4140324592590332,
0.06044890359044075,
-0.11560048162937164,
0.24973289668560028,
0.17117178440093994,
-0.05280694365501404,
-0.022771162912249565,
0.10522802174091339,
-0.24641312658786774,
-0.21750374138355255,
0.268171101808548,
-0.24740718305110931,
-0.19411969184875488,
0.03836696594953537,
0.19836916029453278,
0.07875271141529083,
-0.393008291721344,
-0.1466951221227646,
0.36531689763069153,
-0.23461775481700897,
0.12756526470184326,
-0.1288623958826065,
0.052811574190855026,
0.018930703401565552,
0.09221802651882172,
0.14684419333934784,
0.025620711967349052,
0.2153654843568802,
-0.023365844041109085,
0.27881893515586853,
0.04812286049127579,
0.26127272844314575,
-0.15097303688526154,
0.08040889352560043,
-0.20186080038547516,
-0.13843479752540588,
0.09394540637731552,
-0.08649586886167526,
0.15963172912597656,
0.017668087035417557,
0.1404695361852646,
0.055606842041015625,
0.17712099850177765,
0.4560503661632538,
0.15993741154670715,
-0.39191150665283203,
0.09343383461236954,
0.09160444885492325,
-0.014086333103477955,
0.34713223576545715,
0.15237031877040863,
0.11607109010219574,
0.12886902689933777,
0.060007378458976746,
-0.24114643037319183,
0.13929015398025513,
-0.09263142943382263,
-0.12261881679296494,
0.06761057674884796,
0.22347909212112427,
0.07768473774194717,
0.19841580092906952,
0.1302579641342163,
0.04334371164441109,
-0.19178438186645508,
-0.011329703964293003,
-0.021278532221913338,
0.02166779525578022,
0.04611450806260109,
-0.2378346472978592,
-0.2948214113712311,
-0.10495037585496902,
-0.25322604179382324,
0.07976233959197998,
0.13444720208644867,
0.02697320096194744,
-0.07023503631353378,
0.10357002913951874,
0.18190033733844757,
-0.03794974461197853,
-0.18520185351371765,
-0.05994192883372307,
0.2679230570793152,
-0.16268858313560486,
0.15977390110492706,
0.12279526144266129,
0.19541233777999878,
-0.153126522898674,
-0.24208542704582214,
-0.03848316892981529,
0.13040465116500854,
0.03730814903974533,
-0.3345257043838501,
-0.00912413839250803,
-0.1895815134048462,
-0.13611163198947906,
0.11105609685182571,
0.04228673130273819,
-0.08554472774267197,
-0.00423625111579895,
-0.23259350657463074,
0.3572234511375427,
0.23468352854251862,
0.24150128662586212,
0.03560451418161392,
0.17384308576583862,
0.2382999062538147,
-0.20485059916973114,
-0.08871201425790787,
0.18770749866962433,
0.07253929227590561,
0.08590412884950638,
0.06593981385231018,
-0.07534288614988327,
0.14731337130069733,
-0.11189712584018707,
-0.1726474016904831,
0.25346729159355164,
0.19034700095653534,
-0.09113506972789764,
-0.2884332239627838,
-0.08692404627799988,
-0.1973288506269455,
0.10804852843284607,
-0.03211649879813194,
-0.16004903614521027,
0.1477232128381729,
0.13588948547840118,
-0.08574932813644409,
0.00017603981541469693,
-0.3579676151275635,
-0.09748716652393341,
-0.11418195813894272,
-0.18997572362422943,
0.0089018689468503,
0.06573828309774399,
0.07842545956373215,
-0.226180762052536,
0.06902237236499786,
-0.1365521401166916,
-0.1952233463525772,
0.01816423051059246,
-0.25670894980430603,
-0.05077073723077774,
0.38696789741516113,
0.058338798582553864,
-0.08500150591135025,
-0.06266556680202484,
-0.049626488238573074,
0.302530437707901,
-0.08889748156070709,
-0.30253076553344727,
0.017930971458554268,
-0.09001188725233078,
0.11566948890686035,
0.07801937311887741,
-0.2701725363731384,
-0.24792754650115967,
-0.28686651587486267,
0.17953450977802277,
0.06510517746210098,
-0.023813365027308464,
-0.09256059676408768,
-0.17358532547950745,
0.060577087104320526,
0.23728443682193756,
0.053123004734516144,
0.17239327728748322,
-0.1353456676006317,
-0.1880658119916916,
-0.07949153333902359,
-0.3205789625644684,
0.23072589933872223,
0.3459250032901764,
0.006527877878397703,
-0.33820614218711853,
0.1174955666065216,
-0.0659034326672554,
0.2727369964122772,
-0.12101204693317413,
0.09772314131259918,
-0.032329898327589035,
0.030854258686304092,
0.2548237144947052,
-0.02806582674384117,
-0.15270330011844635,
0.23316439986228943,
-0.034263383597135544,
-0.21656282246112823,
0.05116594582796097,
0.26110416650772095,
-0.03829367086291313,
0.06365422904491425,
-0.16473329067230225,
0.09510999917984009,
-0.12723799049854279,
-0.05039423331618309,
0.02969714254140854,
0.017182650044560432,
0.008021474815905094,
-0.4184719920158386,
0.25162696838378906,
0.27237847447395325,
-0.04686309024691582,
0.016195673495531082,
-0.1782536804676056,
-0.06031866371631622,
-0.2090301513671875,
0.07822736352682114,
-0.06203621253371239,
-0.12544308602809906,
-0.13760998845100403,
-0.2269018441438675,
-0.10956797003746033,
-0.309518426656723,
-0.05793082341551781,
-0.19012799859046936,
-0.07680816203355789,
-0.3021167516708374,
0.006789451465010643,
0.0988302007317543,
0.2681860327720642,
-0.07050850987434387,
-0.09752093255519867,
0.005729879718273878,
-0.01641189493238926,
0.14808689057826996,
0.08541520684957504,
0.2312804013490677,
-0.077390156686306,
-0.11489876359701157,
0.04577891156077385,
-0.18700233101844788,
-0.46894708275794983,
-0.050683390349149704,
0.14514842629432678,
0.005315281450748444,
-0.18433476984500885,
-0.031828224658966064,
-0.33704519271850586,
0.17079639434814453,
0.05476020649075508,
0.2928793132305145,
0.025421403348445892,
0.34998005628585815,
0.003571426961570978,
-0.03715008497238159,
-0.21181540191173553,
0.02773202769458294,
0.053498636931180954,
0.06526236236095428,
-0.3562975823879242,
0.34990188479423523,
-0.1732313632965088,
0.2466992437839508,
-0.04043294116854668,
0.5589889287948608,
0.4727126359939575,
0.11052653193473816,
-0.187713161110878,
0.12003777921199799,
-0.14228147268295288,
0.089110367000103,
-0.34127601981163025,
-0.07343412190675735,
0.134109228849411,
0.2221023142337799,
0.13819925487041473,
0.1589098572731018,
0.09969589114189148,
-0.09547146409749985,
0.08475282788276672,
0.19487041234970093,
0.1696292757987976,
0.09595879167318344,
-0.061846692115068436,
0.35592132806777954,
0.07697691023349762,
0.2493743896484375,
0.038524333387613297,
-0.2895694077014923,
0.22902250289916992,
-0.2626762390136719,
-0.18187040090560913,
0.20693781971931458,
0.03795822337269783,
0.08592016249895096,
0.2617571949958801,
0.004021537024527788,
0.11803776025772095,
-0.21977350115776062,
-0.11299135535955429,
0.13502252101898193,
0.013979998417198658,
-0.17625245451927185,
0.26987794041633606,
-0.34391650557518005,
0.14934830367565155,
-0.04726247861981392,
0.11402010172605515,
-0.418032169342041,
0.12319175899028778,
-0.3776932656764984,
-0.12383970618247986,
-0.014050710014998913,
-0.1275055855512619,
0.05928587168455124,
-0.14233116805553436,
-0.05087422952055931,
0.19978956878185272,
0.30339351296424866,
-0.09664461761713028,
0.07849893718957901,
-0.11456994712352753,
0.422850102186203,
-0.06445130705833435,
-0.021288977935910225,
0.29001832008361816,
0.20818749070167542,
-0.22654034197330475,
-0.2655324637889862,
0.24477462470531464,
0.2699819803237915,
-0.15302354097366333,
0.08400190621614456,
-0.34841981530189514,
-0.28588515520095825,
-0.05313342809677124,
-0.12909327447414398,
0.1784450113773346,
0.063843734562397,
0.185720294713974,
0.03178364783525467,
0.18259376287460327,
-0.10557908564805984,
0.5146365165710449,
0.23658694326877594,
-0.5154852867126465,
-0.08284743875265121,
0.03647396340966225,
0.2345004826784134,
-0.051264166831970215,
-0.004241848364472389,
-0.17193976044654846,
0.3246130347251892,
-0.4494458734989166,
0.039559271186590195,
-0.10934777557849884,
0.2725255787372589,
0.1711088865995407,
0.22677741944789886,
0.10676852613687515,
0.5890815854072571,
-0.2543606758117676,
-0.20499224960803986,
-0.11760682612657547,
-0.03333916515111923,
0.09414678812026978,
0.08350785076618195,
0.26411646604537964,
-0.23607438802719116,
-0.21314415335655212,
0.02357150986790657,
-0.18820810317993164,
0.16136129200458527,
-0.052546702325344086,
-0.13163045048713684,
-0.2677805721759796,
-0.12794433534145355,
0.15191411972045898,
-0.1001935601234436,
0.2519938051700592,
-0.2249869704246521,
0.1908547729253769,
-0.31129270792007446,
-0.14841178059577942,
0.03237231448292732,
0.08675293624401093,
0.046308793127536774,
0.08477161824703217,
-0.01147489994764328,
-0.02194598875939846,
-0.05739753320813179,
0.07106184959411621,
0.18327884376049042,
-0.14669176936149597,
-0.11599016189575195,
0.03404787555336952,
-0.45506390929222107,
0.177045539021492,
-0.24697890877723694,
0.1652548760175705,
0.04430583491921425,
0.03521278500556946,
-0.19110263884067535,
-0.29491540789604187,
0.047231242060661316,
0.2116583287715912,
0.04592246562242508,
-0.2678285241127014,
-0.11065839976072311,
0.27938029170036316,
0.11588355153799057,
-0.09489202499389648,
-0.08728987723588943,
-0.00998874194920063,
0.0951634868979454,
0.2477031946182251,
-0.07773318141698837,
0.13287630677223206,
0.05174127593636513,
0.10535846650600433,
-0.04052590951323509,
-0.3218787908554077,
0.009930899366736412,
-0.13169912993907928,
-0.14787256717681885,
0.1768898069858551,
0.015992015600204468,
0.18321391940116882,
-0.0894664078950882,
0.006366274785250425,
-0.011460580863058567,
-0.021678755059838295
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. suspected in individuals with any of the following presentations.Neonatal-onset propionic acidemia (PA) is the most common clinical form of PA. In the first few days of life, infants present with:LethargyPoor feedingVomitingHypotoniaWithout treatment, this can progress to encephalopathy and cardiorespiratory failure.Symptoms may be evident in the infant before NBS results are available.Late-onset PA can present with a variety of concerns including:Developmental delayIntellectual disabilityFailure to thriveChronic gastrointestinal complaintsProtein intoleranceAcute psychosisHypotoniaMovement disorders such as dystonia and choreoathetosisAcute decompensation can be precipitated by metabolic stressors including infection, injury, or surgery.Cardiomyopathy can occur as an apparently isolated clinical phenomenon in previously healthy individuals without documented episodes of metabolic decompensation or neurocognitive deficits .TestingNewborn screening (NBS). Detection of PA in the neonatal period is possible using acylcarnitine analysis by tandem mass spectrometry | [
-0.158054918050766,
0.019372230395674706,
-0.11022888123989105,
-0.1360430121421814,
0.028077440336346626,
-0.11249532550573349,
-0.10922416299581528,
-0.10020618885755539,
-0.042574476450681686,
-0.2296259105205536,
0.03258232772350311,
0.10538402199745178,
0.04629257693886757,
0.049932193011045456,
-0.3085436522960663,
0.09341617673635483,
0.13656719028949738,
-0.025145534425973892,
-0.031173547729849815,
-0.20383378863334656,
0.048691049218177795,
-0.3978380858898163,
0.015529351308941841,
0.0022576621267944574,
0.459023654460907,
-0.1476471871137619,
0.179522305727005,
-0.33256128430366516,
0.2809622883796692,
0.22501365840435028,
0.08112013339996338,
0.1507878452539444,
0.19116804003715515,
-0.43994131684303284,
-0.009519890882074833,
-0.13862261176109314,
0.12578582763671875,
-0.21152009069919586,
-0.05379234626889229,
-0.19359298050403595,
0.270760715007782,
-0.16322897374629974,
0.2649874985218048,
-0.02316652238368988,
0.1798875480890274,
0.010800992138683796,
0.037324488162994385,
-0.18128645420074463,
-0.1552349030971527,
0.3718929886817932,
0.23580381274223328,
-0.15568360686302185,
-0.2698250114917755,
0.009892350994050503,
0.14884017407894135,
-0.11525579541921616,
-0.17991600930690765,
-0.05867321789264679,
-0.11719589680433273,
0.2675248980522156,
0.11356042325496674,
-0.1707385629415512,
-0.055835749953985214,
-0.22601118683815002,
0.16535361111164093,
-0.12499905377626419,
-0.14366574585437775,
0.008774424903094769,
0.2461070865392685,
-0.12394440174102783,
0.06545180082321167,
-0.06504291296005249,
-0.07790450006723404,
0.1271481215953827,
-0.10641319304704666,
0.06568921357393265,
0.1642446666955948,
0.24397477507591248,
-0.2063872069120407,
-0.40549951791763306,
-0.2563685178756714,
-0.008008773438632488,
0.07696512341499329,
-0.14810484647750854,
-0.21692171692848206,
0.04279503598809242,
0.38682952523231506,
0.0491652749478817,
-0.06342193484306335,
0.3120579123497009,
0.2087119072675705,
0.009573811665177345,
-0.0018244270468130708,
-0.015241050161421299,
0.04640774428844452,
-0.08408429473638535,
0.2507306933403015,
0.08267546445131302,
-0.24767741560935974,
-0.03490866720676422,
0.04581194370985031,
0.04017506167292595,
-0.038534652441740036,
0.01835348829627037,
-0.08588957786560059,
0.1965184211730957,
-0.16171078383922577,
-0.07053189724683762,
-0.02618222124874592,
0.06570063531398773,
0.1375453919172287,
-0.17768366634845734,
0.21526047587394714,
-0.09424769878387451,
-0.5031899213790894,
0.13391834497451782,
-0.15991446375846863,
0.29648417234420776,
-0.04785870388150215,
0.13869759440422058,
0.070761539041996,
0.07351066172122955,
0.020188411697745323,
0.059103403240442276,
-0.08684324473142624,
0.10305365920066833,
0.07377021014690399,
0.18817108869552612,
0.1854436993598938,
-0.0049883597530424595,
0.05571075901389122,
0.10244494676589966,
0.005057095550000668,
-0.18028651177883148,
0.13774465024471283,
-0.04572303220629692,
-0.42896023392677307,
-0.4284643828868866,
-0.12567849457263947,
-0.08261732012033463,
0.07146937400102615,
0.2046978622674942,
0.28809380531311035,
0.23823638260364532,
0.24817390739917755,
0.056927457451820374,
0.4610154628753662,
-0.12823797762393951,
0.22982032597064972,
-0.0595066212117672,
-0.09691488742828369,
-0.22300449013710022,
0.19427822530269623,
-0.028625773265957832,
-0.16979989409446716,
0.20875495672225952,
0.07698428630828857,
0.17918923497200012,
-0.1556425392627716,
0.12681375443935394,
-0.1660691499710083,
-0.10060214251279831,
-0.13660450279712677,
0.031178761273622513,
-0.0909457877278328,
0.07534962892532349,
-0.5991432666778564,
-0.0914134830236435,
-0.11636075377464294,
0.03867574408650398,
-0.006179917138069868,
-0.044702280312776566,
-0.07994768768548965,
0.1491553783416748,
0.006640760228037834,
0.01650986820459366,
-0.2399926483631134,
-0.039566900581121445,
-0.15703223645687103,
0.27314674854278564,
0.16067957878112793,
-0.025014817714691162,
-0.3327181041240692,
0.03482087701559067,
-0.178671732544899,
-0.15742364525794983,
0.11839230358600616,
0.16304722428321838,
-0.10562098771333694,
0.26800015568733215,
0.018915371969342232,
0.20818963646888733,
0.0610649473965168,
0.3308207094669342,
-0.014743171632289886,
-0.3273721933364868,
0.2972482442855835,
0.027443325147032738,
-0.10863308608531952,
-0.07897580415010452,
-0.22311779856681824,
-0.152902752161026,
0.1157301589846611,
-0.18626418709754944,
0.000861720705870539,
-0.2857530415058136,
-0.004070705734193325,
-0.10831363499164581,
0.014263063669204712,
0.08129439502954483,
-0.14018438756465912,
0.36723044514656067,
-0.3188396394252777,
-0.07526615262031555,
-0.2093529999256134,
-0.08801604807376862,
0.045160286128520966,
-0.07885102927684784,
-0.046901021152734756,
0.1669158637523651,
-0.06370886415243149,
-0.055713508278131485,
0.011850252747535706,
-0.298032283782959,
-0.09764523804187775,
0.06902238726615906,
-0.4388412535190582,
-0.18126781284809113,
0.19291384518146515,
-0.3440413475036621,
-0.19768832623958588,
0.16180507838726044,
0.00582701014354825,
0.22122113406658173,
-0.00029709210502915084,
-0.15308940410614014,
-0.07817281782627106,
0.3988938331604004,
-0.18927206099033356,
-0.22703216969966888,
-0.46738559007644653,
-0.18700498342514038,
0.007918045856058598,
0.058749035000801086,
0.015218970365822315,
0.11901811510324478,
-0.08960150927305222,
0.1519738882780075,
-0.03444693237543106,
0.12327012419700623,
-0.04452699422836304,
0.1686657965183258,
-0.03463355079293251,
0.15847717225551605,
-0.4877178370952606,
-0.2653543949127197,
0.1823694109916687,
0.18495546281337738,
0.12646432220935822,
-0.15889455378055573,
-0.14448942244052887,
0.31840780377388,
-0.05648089945316315,
0.16442595422267914,
0.14233550429344177,
-0.01384570449590683,
-0.2638406753540039,
0.18498259782791138,
0.01721867173910141,
-0.1935541331768036,
-0.10288877785205841,
0.1477510780096054,
0.02613072656095028,
0.172365203499794,
-0.4035053253173828,
-0.3145226836204529,
0.1566477119922638,
0.33495286107063293,
-0.16583600640296936,
-0.05104739964008331,
-0.23339848220348358,
0.26560598611831665,
0.07702162861824036,
-0.047696445137262344,
0.17210401594638824,
0.08509598672389984,
-0.009898126125335693,
0.025914227589964867,
-0.0009728333097882569,
0.15179796516895294,
-0.03440764173865318,
0.03825068473815918,
-0.2741863429546356,
0.022137226536870003,
0.3162961006164551,
0.29479730129241943,
0.013229772448539734,
0.028430132195353508,
0.07222943007946014,
0.10315653681755066,
0.06290728598833084,
0.06305845081806183,
0.2717593014240265,
-0.04943650960922241,
-0.13813920319080353,
0.09795017540454865,
-0.06755536049604416,
-0.17705552279949188,
0.14127177000045776,
0.2662433683872223,
-0.10974143445491791,
-0.1848486065864563,
-0.28972625732421875,
-0.0606539249420166,
-0.026791565120220184,
-0.0850781723856926,
0.12029926478862762,
0.16467422246932983,
0.1146828830242157,
0.13239827752113342,
-0.1470658928155899,
0.007272352464497089,
0.02270212396979332,
0.15501530468463898,
-0.43236401677131653,
-0.10304737091064453,
0.005402101669460535,
-0.02661542221903801,
0.010534525848925114,
0.04482266679406166,
-0.08444292843341827,
0.11470425128936768,
0.07951054722070694,
-0.21262915432453156,
0.22021697461605072,
-0.24480046331882477,
0.3953629434108734,
0.1432502716779709,
-0.1062173843383789,
0.14155377447605133,
0.17983709275722504,
-0.34732455015182495,
0.051732614636421204,
-0.3264543116092682,
-0.3807571232318878,
0.05063551291823387,
-0.16806460916996002,
0.27673590183258057,
0.1284056454896927,
-0.04259997606277466,
-0.025387458503246307,
0.10125193744897842,
-0.2747555375099182,
-0.12009768187999725,
0.2572055459022522,
-0.21310138702392578,
-0.2338845431804657,
-0.00321390014141798,
0.14091123640537262,
0.06305326521396637,
-0.29625532031059265,
-0.015746451914310455,
0.2835801839828491,
-0.23473161458969116,
0.09576448798179626,
-0.11313674598932266,
-0.1410224884748459,
-0.03809317201375961,
0.18047097325325012,
0.012177867814898491,
-0.11249575763940811,
0.1127883568406105,
-0.09835051745176315,
0.3011209964752197,
-0.009669916704297066,
0.2566695213317871,
-0.047420285642147064,
-0.02620653621852398,
-0.3271969258785248,
-0.1426267772912979,
0.21152372658252716,
-0.032853949815034866,
0.13500554859638214,
0.026533666998147964,
0.014541629701852798,
0.10087153315544128,
0.05803078040480614,
0.3937146067619324,
0.26888206601142883,
-0.48953840136528015,
0.06631646305322647,
0.11580833792686462,
-0.09189482778310776,
0.2672472298145294,
0.20420882105827332,
0.031478043645620346,
0.09825821220874786,
0.1623019427061081,
-0.11580052226781845,
0.0576605498790741,
-0.07893471419811249,
0.03362436965107918,
0.21053722500801086,
0.19598402082920074,
0.056636784225702286,
0.23151524364948273,
0.258880078792572,
0.18205344676971436,
-0.15615996718406677,
0.019838832318782806,
-0.00022620361414738,
-0.05710989981889725,
-0.009676960296928883,
-0.24869810044765472,
-0.21100783348083496,
0.043948449194431305,
-0.17854009568691254,
0.05396386981010437,
0.11904523521661758,
-0.05809495225548744,
-0.01410677656531334,
0.13517700135707855,
0.037222933024168015,
-0.011579853482544422,
-0.1288052201271057,
0.09890121221542358,
0.27934297919273376,
-0.1880291998386383,
0.2105487585067749,
0.24082067608833313,
0.22872211039066315,
-0.14176905155181885,
-0.1938759833574295,
-0.06169124320149422,
0.1540953814983368,
0.07046129554510117,
-0.19447040557861328,
0.043626122176647186,
-0.2020743489265442,
-0.13095064461231232,
0.09065208584070206,
0.05423340946435928,
-0.024504512548446655,
-0.09315630793571472,
-0.31955206394195557,
0.23934674263000488,
0.3355485796928406,
0.1558605581521988,
0.08339155465364456,
0.255337119102478,
0.20022687315940857,
-0.1701320856809616,
-0.08438913524150848,
0.18284361064434052,
0.03347126021981239,
0.14817172288894653,
0.1388675421476364,
-0.09403784573078156,
0.1600085198879242,
-0.01242442149668932,
-0.053810931742191315,
0.2651817798614502,
0.12896473705768585,
-0.1436348855495453,
-0.3244686424732208,
-0.03807967156171799,
-0.1735754907131195,
0.27969637513160706,
0.05519673228263855,
-0.016507567837834358,
-0.017009856179356575,
0.14520376920700073,
-0.04088445380330086,
0.16435955464839935,
-0.3504207730293274,
-0.20758691430091858,
-0.056101154536008835,
-0.24313323199748993,
-0.06249840557575226,
0.04156816378235817,
0.06548570841550827,
-0.1807326227426529,
0.09547705948352814,
-0.1255072057247162,
-0.18134543299674988,
0.034379370510578156,
-0.2682883143424988,
-0.006937831174582243,
0.31202420592308044,
0.23195292055606842,
-0.114958256483078,
-0.1172296479344368,
-0.16155816614627838,
0.4440491795539856,
-0.16528408229351044,
-0.39838048815727234,
0.04212355241179466,
-0.12230255454778671,
0.043301068246364594,
-0.02309538424015045,
-0.18087749183177948,
-0.15578052401542664,
-0.19168728590011597,
0.230015367269516,
-0.027306530624628067,
-0.047506872564554214,
-0.06211194023489952,
-0.15865465998649597,
0.032441552728414536,
0.10668404400348663,
-0.036931172013282776,
0.2168148159980774,
-0.10678120702505112,
-0.1478770226240158,
0.036151960492134094,
-0.34002685546875,
0.21543724834918976,
0.40879663825035095,
0.13217735290527344,
-0.2782163619995117,
0.10745468735694885,
-0.08320644497871399,
0.15416747331619263,
-0.12074965238571167,
0.2513277530670166,
-0.052527252584695816,
0.13711293041706085,
0.2660634219646454,
-0.012419443577528,
-0.1426224708557129,
0.10585349798202515,
0.11295854300260544,
-0.30766841769218445,
-0.023867886513471603,
0.23011747002601624,
-0.09763620793819427,
0.026668168604373932,
-0.22670651972293854,
0.08658167719841003,
-0.15500394999980927,
-0.11653684079647064,
0.008723529055714607,
0.015338459052145481,
0.07260973751544952,
-0.24479703605175018,
0.25161805748939514,
0.2601315975189209,
0.015077796764671803,
0.04882260784506798,
-0.1669350564479828,
-0.019757002592086792,
-0.22592200338840485,
0.029957685619592667,
-0.10934542119503021,
-0.25669991970062256,
-0.1253814548254013,
-0.38691821694374084,
-0.07118942588567734,
-0.23597854375839233,
0.035210710018873215,
-0.296018123626709,
-0.08440922200679779,
-0.2978256046772003,
0.16520965099334717,
0.023215459659695625,
0.28484320640563965,
-0.05939515307545662,
-0.15762989223003387,
0.049509868025779724,
-0.041442256420850754,
0.0718953013420105,
0.06555292755365372,
0.2120693176984787,
-0.036390598863363266,
-0.08635921031236649,
0.0526277981698513,
-0.08976063132286072,
-0.4990248680114746,
-0.04910225793719292,
0.13489942252635956,
-0.07932604104280472,
-0.2040916532278061,
0.07006470859050751,
-0.44533511996269226,
0.1539270281791687,
-0.09197982400655746,
0.24225732684135437,
0.08631175011396408,
0.40345847606658936,
0.032380007207393646,
-0.047542087733745575,
-0.22999517619609833,
0.0027830160688608885,
0.019867531955242157,
0.08805934339761734,
-0.28325462341308594,
0.2965420186519623,
-0.19517888128757477,
0.1756397783756256,
0.003336018417030573,
0.32677918672561646,
0.34133824706077576,
0.09313414245843887,
-0.23151643574237823,
-0.032091401517391205,
-0.2288307249546051,
0.12818853557109833,
-0.43840059638023376,
-0.22085288166999817,
0.08591756969690323,
0.21737845242023468,
0.14794470369815826,
0.2202310413122177,
-0.010902345180511475,
-0.071672223508358,
0.037889063358306885,
0.20167647302150726,
0.09617381542921066,
0.13866543769836426,
-0.04911058768630028,
0.23150847852230072,
0.009030641987919807,
0.19343139231204987,
-0.03428115323185921,
-0.1930772066116333,
0.14516939222812653,
-0.13498957455158234,
-0.10308569669723511,
0.18627089262008667,
-0.08468445390462875,
-0.03510681167244911,
0.29071560502052307,
0.0452023483812809,
0.0129727553576231,
-0.18601956963539124,
-0.019368786364793777,
0.17921745777130127,
0.07510243356227875,
-0.21792243421077728,
0.2105002999305725,
-0.4181351959705353,
0.1792934685945511,
-0.20766329765319824,
0.11981997638940811,
-0.37736189365386963,
0.14548540115356445,
-0.2827155590057373,
-0.22808076441287994,
0.04098876565694809,
-0.15553106367588043,
0.09313172101974487,
-0.19071391224861145,
-0.004535391461104155,
0.2890786826610565,
0.2618118226528168,
-0.14642365276813507,
0.12763431668281555,
-0.03353625908493996,
0.3638443946838379,
-0.028782611712813377,
0.058275409042835236,
0.21773496270179749,
0.13760298490524292,
-0.19603081047534943,
-0.2118741124868393,
0.2303277552127838,
0.2577989995479584,
-0.062165141105651855,
0.02651701681315899,
-0.292945921421051,
-0.2531055808067322,
0.02220735512673855,
-0.026989230886101723,
0.11322823911905289,
-0.01840488612651825,
0.13314440846443176,
0.04165605828166008,
0.24366495013237,
-0.16419638693332672,
0.34600940346717834,
0.1261913776397705,
-0.5065361261367798,
-0.06223857030272484,
0.05103189870715141,
0.2864575684070587,
-0.07420545071363449,
0.00036902277497574687,
-0.23922744393348694,
0.38907232880592346,
-0.41092944145202637,
0.1503671109676361,
-0.07210566103458405,
0.2356657236814499,
0.11673863977193832,
0.06874115765094757,
0.029904091730713844,
0.4854143261909485,
-0.19750289618968964,
-0.31525421142578125,
-0.11448091268539429,
-0.15840113162994385,
-0.001802913029678166,
0.12842804193496704,
0.28870755434036255,
-0.18872226774692535,
-0.05846325680613518,
0.03890109062194824,
-0.15268442034721375,
0.06129097938537598,
-0.0331229642033577,
-0.0531783290207386,
-0.14157263934612274,
-0.03623800724744797,
0.2041901797056198,
-0.005068217404186726,
0.15852132439613342,
-0.019904591143131256,
0.17581351101398468,
-0.28449589014053345,
-0.15232613682746887,
0.0519963838160038,
-0.028300806879997253,
0.07240083813667297,
0.10870713740587234,
0.0014084515860304236,
-0.044661760330200195,
-0.08247923851013184,
0.00741919269785285,
0.23021772503852844,
-0.13607211410999298,
-0.20635955035686493,
-0.07835692167282104,
-0.4448833763599396,
0.19117847084999084,
-0.15747202932834625,
0.12601378560066223,
0.029159149155020714,
-0.009013287723064423,
-0.15623822808265686,
-0.21726572513580322,
-0.053216010332107544,
0.14697293937206268,
0.11362449079751968,
-0.14679712057113647,
-0.06635167449712753,
0.18079201877117157,
0.07368578016757965,
-0.16326174139976501,
-0.14582116901874542,
-0.12066575884819031,
0.10266070812940598,
0.06771459430456161,
-0.04129253700375557,
0.204503133893013,
0.02235739678144455,
0.10316745936870575,
-0.13050594925880432,
-0.2911600172519684,
0.0274013951420784,
0.054906632751226425,
-0.1834334135055542,
0.012592177838087082,
-0.02363990619778633,
0.1749345064163208,
-0.1363096982240677,
0.09474452584981918,
0.16732774674892426,
0.08055467903614044
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. ctual disabilityFailure to thriveChronic gastrointestinal complaintsProtein intoleranceAcute psychosisHypotoniaMovement disorders such as dystonia and choreoathetosisAcute decompensation can be precipitated by metabolic stressors including infection, injury, or surgery.Cardiomyopathy can occur as an apparently isolated clinical phenomenon in previously healthy individuals without documented episodes of metabolic decompensation or neurocognitive deficits .TestingNewborn screening (NBS). Detection of PA in the neonatal period is possible using acylcarnitine analysis by tandem mass spectrometry (MS/MS) on dried blood spots.Acylcarnitine analysis reveals elevated propionylcarnitine (C3).Secondary markers including methionine, C3/C2, and C3/C16 ratios can be helpful to increase diagnostic accuracy .Biochemical analysis. Deficiency of propionyl-CoA carboxylase results in accumulation of propionic acid and propionyl-CoA related metabolites in plasma and urine, causing a wide range of laboratory test abnormalities (Figure 1).Figure 1. Metabolic pathway. Prop | [
0.012080661021173,
0.0012173152063041925,
-0.19158516824245453,
-0.3394787311553955,
0.11404602974653244,
0.17527133226394653,
0.045299749821424484,
-0.19130517542362213,
-0.004718640353530645,
-0.2145848572254181,
0.1402985155582428,
0.21011240780353546,
-0.060432661324739456,
0.039680659770965576,
-0.12349999696016312,
0.20684491097927094,
0.14241541922092438,
-0.09955315291881561,
-0.024355513975024223,
-0.222615584731102,
0.24187831580638885,
-0.20404639840126038,
-0.10276830941438675,
0.1837456226348877,
0.33413079380989075,
-0.1286611706018448,
0.06996695697307587,
-0.29261258244514465,
0.21119143068790436,
0.11681526154279709,
-0.05654126778244972,
-0.11906952410936356,
0.14911200106143951,
-0.11272254586219788,
-0.04845745861530304,
-0.013522017747163773,
-0.09844270348548889,
-0.3433751165866852,
-0.012547357007861137,
-0.07267901301383972,
0.07390633970499039,
-0.23178847134113312,
0.29116445779800415,
0.022061066702008247,
0.24511726200580597,
-0.3130590617656708,
0.15037937462329865,
-0.16272442042827606,
-0.19813691079616547,
0.11853524297475815,
0.2642568349838257,
-0.36091405153274536,
-0.337941437959671,
0.18809004127979279,
0.20869384706020355,
-0.04691150039434433,
-0.15888746082782745,
-0.020742278546094894,
0.02480681799352169,
0.2934959828853607,
-0.03651849552989006,
-0.04363980144262314,
-0.07304278761148453,
-0.1678236573934555,
0.19571039080619812,
-0.08484823256731033,
0.031776949763298035,
0.1505482941865921,
0.3303793966770172,
0.1644728034734726,
0.11459395289421082,
0.04316733032464981,
0.08048100769519806,
0.025564350187778473,
-0.24520602822303772,
0.07071161270141602,
0.2074289172887802,
-0.08479849994182587,
0.08959988504648209,
-0.3367323577404022,
-0.17873726785182953,
0.07732091099023819,
0.04164953902363777,
0.05220680311322212,
-0.21204890310764313,
0.02258431538939476,
0.13848310708999634,
-0.007181575056165457,
-0.40265515446662903,
0.18270321190357208,
0.06270726025104523,
-0.07888874411582947,
0.15596391260623932,
0.07261558622121811,
0.0973261222243309,
-0.2962994873523712,
0.3531036078929901,
0.11121892184019089,
-0.20999953150749207,
0.13093875348567963,
0.18272124230861664,
0.060760095715522766,
-0.2617982029914856,
-0.26182854175567627,
-0.26473671197891235,
-0.007179048378020525,
-0.27733439207077026,
-0.08565865457057953,
0.06173112243413925,
-0.010608745738863945,
0.318673700094223,
-0.0873846486210823,
0.1798451840877533,
0.13453856110572815,
-0.5124548673629761,
0.11400534212589264,
-0.08839360624551773,
0.30236542224884033,
-0.1257612258195877,
0.20413941144943237,
-0.04210265725851059,
-0.1211136057972908,
0.14345793426036835,
0.23990902304649353,
0.08679492771625519,
0.07791240513324738,
-0.05150328204035759,
-0.283935010433197,
0.2994307577610016,
-0.05186323821544647,
0.036432474851608276,
0.0528063029050827,
-0.031033828854560852,
-0.15781763195991516,
0.24608200788497925,
0.06494645774364471,
-0.32153818011283875,
-0.3264929950237274,
-0.023535775020718575,
0.2010887712240219,
0.06276988238096237,
0.32697200775146484,
0.33783626556396484,
0.17453113198280334,
0.20252126455307007,
-0.01339060626924038,
0.2431594580411911,
-0.11969265341758728,
0.30747509002685547,
0.018463995307683945,
0.16181842982769012,
-0.5790854096412659,
-0.0973408967256546,
-0.12003068625926971,
-0.19434776902198792,
0.13697092235088348,
-0.06914431601762772,
0.2648550271987915,
0.10760851204395294,
-0.014928817749023438,
0.01135290041565895,
-0.07624776661396027,
-0.01586754061281681,
0.07884356379508972,
-0.1560312807559967,
0.21132205426692963,
-0.3953878581523895,
-0.021838197484612465,
0.12334618717432022,
0.19744211435317993,
-0.16460147500038147,
-0.05969323217868805,
-0.024640558287501335,
0.024364396929740906,
0.30942654609680176,
-0.03875827044248581,
-0.11734330654144287,
-0.018307477235794067,
0.04596668854355812,
0.12515199184417725,
0.18941909074783325,
0.21344676613807678,
-0.20318056643009186,
-0.026259789243340492,
-0.09247671067714691,
-0.34452909231185913,
0.0059692529030144215,
-0.26670902967453003,
0.0841446965932846,
0.1482212096452713,
-0.08000632375478745,
-0.0186014287173748,
0.038879092782735825,
0.0634087547659874,
-0.03860096260905266,
-0.21807895600795746,
0.12482297420501709,
0.004696102347224951,
0.031159330159425735,
-0.13981536030769348,
0.023453468456864357,
-0.2149449735879898,
0.07428175210952759,
-0.18862290680408478,
-0.018974192440509796,
-0.1367834061384201,
0.1620372086763382,
-0.26557862758636475,
0.061604876071214676,
0.2169657051563263,
-0.14678199589252472,
0.20546528697013855,
-0.23007597029209137,
0.0453999824821949,
-0.1428097039461136,
0.007498858496546745,
0.05107921361923218,
-0.1705935001373291,
0.0143295181915164,
0.20747274160385132,
-0.022720670327544212,
-0.06605608761310577,
0.04648713767528534,
-0.3143249452114105,
-0.04521544650197029,
0.05311572924256325,
-0.28760597109794617,
-0.2606373429298401,
0.12023743242025375,
-0.13081765174865723,
-0.11753007769584656,
0.055093392729759216,
0.08658364415168762,
0.24145138263702393,
-0.010590573772788048,
-0.3969615399837494,
-0.41906991600990295,
0.18247433006763458,
-0.13920371234416962,
-0.05347905308008194,
-0.39159584045410156,
-0.04321623966097832,
-0.0410105399787426,
0.11285273730754852,
0.10926035791635513,
-0.055866558104753494,
-0.1745322048664093,
-0.11051879078149796,
-0.1667402684688568,
-0.07042186707258224,
-0.048787519335746765,
0.2442415952682495,
-0.06401066482067108,
0.01974577084183693,
-0.37172311544418335,
-0.3210855722427368,
0.21132712066173553,
0.03620821237564087,
-0.0526592954993248,
-0.13207322359085083,
0.08509192615747452,
0.2210690975189209,
0.014491118490695953,
0.08567798882722855,
-0.11992871016263962,
-0.10322871804237366,
-0.2715805172920227,
-0.05450990051031113,
-0.09211737662553787,
-0.030255122110247612,
-0.03766493499279022,
0.11008534580469131,
0.3152168095111847,
0.129547581076622,
-0.22237321734428406,
-0.14915108680725098,
0.1383139044046402,
0.18643991649150848,
-0.24521800875663757,
-0.12700951099395752,
-0.3024480938911438,
0.375699520111084,
-0.10597634315490723,
0.04988067224621773,
0.13850858807563782,
0.16750670969486237,
-0.050587449222803116,
0.021651940420269966,
-0.007148432079702616,
0.11537028104066849,
-0.06271524727344513,
0.2119380384683609,
-0.12130404263734818,
-0.0297937523573637,
0.17789939045906067,
0.11078944802284241,
0.09864536672830582,
-0.11433485150337219,
-0.05333142355084419,
0.17693771421909332,
0.04466737434267998,
0.09020985662937164,
-0.02591243013739586,
-0.29299816489219666,
-0.23107297718524933,
0.1234808936715126,
-0.10767734795808792,
-0.2149212509393692,
0.15983763337135315,
0.16897383332252502,
-0.1453438103199005,
-0.055578507483005524,
-0.34517818689346313,
-0.10887168347835541,
0.011436060070991516,
-0.13522838056087494,
0.2992273271083832,
0.11450713872909546,
0.07930656522512436,
0.30175572633743286,
0.09852267801761627,
-0.10901986807584763,
0.022186297923326492,
-0.012423467822372913,
-0.4314383268356323,
-0.1339871734380722,
-0.2402496486902237,
0.022612053900957108,
-0.1256067454814911,
-0.1470108926296234,
0.38283976912498474,
0.21924035251140594,
-0.22802913188934326,
-0.07136709243059158,
0.414814293384552,
-0.06516990810632706,
0.4123499095439911,
0.26779529452323914,
-0.05580013617873192,
-0.09493424743413925,
0.29932186007499695,
-0.3827730715274811,
0.0477580763399601,
-0.19282296299934387,
-0.16211195290088654,
-0.0894213393330574,
0.13132289052009583,
0.17596501111984253,
0.15982046723365784,
0.0056349001824855804,
-0.05039070174098015,
0.1921299248933792,
-0.007877820171415806,
-0.09778197854757309,
0.3765387237071991,
-0.28519687056541443,
-0.11793874949216843,
0.059465229511260986,
0.18636663258075714,
-0.00993514247238636,
-0.27222979068756104,
-0.09942454099655151,
0.14369331300258636,
-0.09446533024311066,
0.0955624133348465,
-0.11046969890594482,
-0.06733208149671555,
0.2902226150035858,
0.1759311854839325,
0.1824987828731537,
0.045804306864738464,
0.08650597929954529,
0.1720198094844818,
0.05583861470222473,
-0.05283988267183304,
0.038127586245536804,
0.057777758687734604,
0.07731019705533981,
-0.29005518555641174,
-0.09403576701879501,
0.13415902853012085,
0.0696992352604866,
-0.03931155055761337,
0.1768541932106018,
-0.011524330824613571,
0.12677061557769775,
0.0762680396437645,
0.16776490211486816,
0.19664877653121948,
-0.4769582152366638,
-0.006887773051857948,
0.05195758491754532,
0.1596619188785553,
0.24948737025260925,
0.1606132686138153,
0.16380675137043,
0.09627455472946167,
-0.10175982862710953,
-0.11798211932182312,
0.08745937794446945,
0.001880042371340096,
0.2610255181789398,
0.23254713416099548,
0.03872523084282875,
-0.030642934143543243,
0.24596014618873596,
0.03239201754331589,
0.18179523944854736,
-0.041696175932884216,
-0.17084509134292603,
0.15894052386283875,
-0.011748244985938072,
-0.12796913087368011,
-0.13408993184566498,
-0.024196665734052658,
-0.13880343735218048,
-0.2964807450771332,
0.1384039968252182,
0.07403257489204407,
-0.13318054378032684,
0.01711699552834034,
0.307129830121994,
0.04537874460220337,
0.0814584493637085,
-0.2105310559272766,
-0.05263776332139969,
0.11750492453575134,
-0.10956110060214996,
0.23355555534362793,
0.36563748121261597,
0.17107048630714417,
-0.06316695362329483,
-0.04398943856358528,
-0.08286652714014053,
-0.008487009443342686,
-0.06558582931756973,
-0.2451605647802353,
0.06719350069761276,
-0.06290528178215027,
-0.1954127699136734,
0.31177470088005066,
-0.05068385601043701,
-0.18897341191768646,
-0.02122236229479313,
-0.13383625447750092,
0.09140729159116745,
0.2738698124885559,
0.17637284100055695,
0.14372730255126953,
0.2847747802734375,
0.2930319309234619,
-0.07452356815338135,
0.043021075427532196,
0.07292991876602173,
0.1140189915895462,
-0.06936068832874298,
0.12437796592712402,
-0.0441884770989418,
0.1683730036020279,
-0.21376201510429382,
-0.11518292129039764,
0.18024033308029175,
0.1486310511827469,
-0.059680961072444916,
-0.24187397956848145,
0.10248994827270508,
-0.009044173173606396,
0.05121828243136406,
0.12531451880931854,
-0.040445681661367416,
-0.1091892197728157,
0.04944218322634697,
-0.037528958171606064,
0.016009733080863953,
-0.15531350672245026,
-0.027644049376249313,
0.07459647953510284,
0.011784886009991169,
0.059448108077049255,
0.22816286981105804,
0.02000810205936432,
-0.05533060058951378,
0.021812135353684425,
-0.2253957837820053,
-0.26865053176879883,
0.07199562340974808,
0.03823643922805786,
-0.010166365653276443,
0.21067364513874054,
0.20154458284378052,
0.05393662676215172,
0.19850674271583557,
0.06291688233613968,
0.3524314761161804,
-0.1588897854089737,
-0.10067170113325119,
-0.08637489378452301,
-0.1157241016626358,
-0.00464135967195034,
-0.01997912861406803,
-0.019100261852145195,
-0.14288334548473358,
-0.2152525782585144,
0.195927232503891,
-0.04121284931898117,
0.047795966267585754,
-0.14492657780647278,
-0.11859618872404099,
0.11921393126249313,
0.2044541984796524,
-0.10072214901447296,
0.1790827065706253,
0.010923636145889759,
-0.1045018658041954,
0.03634042665362358,
-0.3876541256904602,
0.250976026058197,
0.27374139428138733,
-0.025518830865621567,
-0.2647342085838318,
-0.04648449644446373,
-0.14922860264778137,
0.20134244859218597,
-0.16983307898044586,
0.1759723424911499,
-0.102702297270298,
0.1144389808177948,
0.23307213187217712,
0.09938026964664459,
-0.17853796482086182,
-0.02130891941487789,
-0.057224467396736145,
-0.37924569845199585,
-0.17934276163578033,
0.30677860975265503,
-0.14457623660564423,
-0.09493274986743927,
-0.28507450222969055,
0.010106034576892853,
-0.037563130259513855,
-0.001481558196246624,
-0.1544318050146103,
0.23137174546718597,
-0.044601570814847946,
-0.5111857056617737,
0.332780659198761,
0.21061231195926666,
0.1453329473733902,
0.04089204594492912,
-0.1851084679365158,
-0.08071167767047882,
-0.11227711290121078,
0.13549800217151642,
0.16481328010559082,
-0.03823939338326454,
-0.2741349935531616,
-0.03327907249331474,
-0.4034060835838318,
-0.07441407442092896,
-0.061842095106840134,
-0.08219902217388153,
-0.260511189699173,
-0.2767503559589386,
0.2292536348104477,
-0.10527510195970535,
0.3351152241230011,
-0.28578418493270874,
0.025745457038283348,
-0.18103671073913574,
-0.3230786919593811,
-0.11483393609523773,
-0.11231978237628937,
-0.1394086480140686,
-0.19067221879959106,
-0.05138418823480606,
0.018686670809984207,
-0.03388384357094765,
-0.5251215696334839,
-0.039016351103782654,
0.12014122307300568,
-0.06174483895301819,
-0.23195654153823853,
0.18566778302192688,
0.0445321649312973,
0.12128697335720062,
-0.09106665849685669,
0.19568033516407013,
0.13351653516292572,
0.2108743041753769,
-0.20181988179683685,
0.0616224929690361,
-0.2895060181617737,
0.031766198575496674,
0.06669197976589203,
-0.03559131547808647,
-0.11329890787601471,
0.22367410361766815,
0.1511751264333725,
0.3264088034629822,
0.07135796546936035,
0.22631484270095825,
0.1732913851737976,
0.008820857852697372,
-0.2519499659538269,
-0.1922696828842163,
0.008822337724268436,
0.2838253676891327,
-0.28060388565063477,
-0.18844585120677948,
-0.05235857516527176,
0.059288859367370605,
-0.028287621214985847,
0.08273937553167343,
-0.08843688666820526,
0.006390457972884178,
0.005521368235349655,
0.1098254844546318,
0.13331064581871033,
0.2157616913318634,
-0.09566989541053772,
0.34020864963531494,
-0.040669996291399,
0.14727184176445007,
-0.04335823655128479,
-0.11986952275037766,
0.07340065389871597,
0.09777607768774033,
-0.04929095134139061,
0.01347291748970747,
-0.12260084599256516,
0.1121605634689331,
0.23415063321590424,
-0.17454354465007782,
-0.08366154879331589,
-0.20974306762218475,
0.11237473040819168,
0.15296773612499237,
-0.11011319607496262,
-0.14322425425052643,
0.16178375482559204,
-0.11831177026033401,
0.16004298627376556,
-0.10300843417644501,
0.19643516838550568,
-0.2204996943473816,
0.04288576543331146,
-0.07223399728536606,
-0.3316677212715149,
-0.14472205936908722,
-0.16599833965301514,
0.1502014696598053,
-0.1649831384420395,
0.15229305624961853,
0.007613124791532755,
0.1854066550731659,
-0.2450142204761505,
0.23706255853176117,
-0.15159115195274353,
0.33025041222572327,
-0.4135478138923645,
0.09988781809806824,
-0.08706890791654587,
0.2953741252422333,
-0.047766853123903275,
-0.0939200296998024,
0.16861698031425476,
0.2961221933364868,
-0.07566387206315994,
0.061566002666950226,
-0.30762699246406555,
-0.19381333887577057,
-0.11422323435544968,
-0.08059345930814743,
0.05683594569563866,
0.20512507855892181,
-0.019019870087504387,
-0.2893563210964203,
0.45440512895584106,
-0.07672157883644104,
0.28263741731643677,
0.2664799988269806,
-0.48685920238494873,
-0.3169994652271271,
-0.060193657875061035,
0.0905393436551094,
0.20542111992835999,
0.06629323214292526,
-0.12594883143901825,
0.22734776139259338,
-0.27930280566215515,
0.050659749656915665,
-0.06905779987573624,
0.16965554654598236,
0.10465913265943527,
0.1042565107345581,
0.07469837367534637,
0.38035187125205994,
-0.238398477435112,
-0.32956355810165405,
-0.025622105225920677,
0.016203703358769417,
0.10670981556177139,
0.030222846195101738,
0.2458048015832901,
-0.23528550565242767,
0.004694635979831219,
0.1435406655073166,
-0.03473387286067009,
-0.009548516944050789,
-0.02197224646806717,
-0.13467910885810852,
-0.07028335332870483,
-0.24065031111240387,
0.28321629762649536,
-0.1379486620426178,
0.36863595247268677,
0.026424821466207504,
0.010824219323694706,
-0.05740979313850403,
-0.17304782569408417,
0.08717435598373413,
0.16365809738636017,
-0.011276978068053722,
-0.08451583236455917,
0.06118089705705643,
-0.01721678301692009,
-0.18575696647167206,
-0.00846095010638237,
0.08811258524656296,
0.00019263480498921126,
-0.4032089114189148,
0.008649527095258236,
-0.47692400217056274,
-0.11073245108127594,
0.06250004470348358,
-0.036595918238162994,
-0.10441100597381592,
0.07254797965288162,
-0.16358551383018494,
-0.27548614144325256,
-0.01814141310751438,
0.11928146332502365,
0.1732906997203827,
-0.2268541157245636,
-0.09779545664787292,
0.18284980952739716,
-0.00855504535138607,
-0.32859545946121216,
-0.11718881875276566,
-0.20358246564865112,
0.27635622024536133,
0.30468544363975525,
-0.06099935248494148,
0.010260151699185371,
0.08024623990058899,
-0.007167269010096788,
0.05972052738070488,
-0.03979736566543579,
0.0373413972556591,
-0.21136294305324554,
-0.1832779347896576,
-0.025698721408843994,
0.08559466153383255,
0.11597000062465668,
-0.0321173332631588,
0.34445756673812866,
0.3383429944515228,
0.17137528955936432
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. nitine analysis by tandem mass spectrometry (MS/MS) on dried blood spots.Acylcarnitine analysis reveals elevated propionylcarnitine (C3).Secondary markers including methionine, C3/C2, and C3/C16 ratios can be helpful to increase diagnostic accuracy .Biochemical analysis. Deficiency of propionyl-CoA carboxylase results in accumulation of propionic acid and propionyl-CoA related metabolites in plasma and urine, causing a wide range of laboratory test abnormalities (Figure 1).Figure 1. Metabolic pathway. Propionyl-CoA carboxylase (PCC) catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA, which enters the Krebs cycle via succinyl-CoA. Sources of propionate include: valine, isoleucine, threonine, methionine, odd-chain fatty (more...)Biochemical findings in propionic acidemia include:Plasma acylcarnitine profile: elevated propionylcarnitine (C3)Urine organic acids:Elevated 3-hydroxypropionatePresence of:Methyl | [
-0.13195988535881042,
-0.15720875561237335,
-0.10889872908592224,
-0.2719667851924896,
0.16375569999217987,
0.06075407937169075,
0.05101495236158371,
-0.17334464192390442,
0.08702544867992401,
-0.3162713646888733,
0.2536028325557709,
0.0863804817199707,
-0.20818431675434113,
-0.21546044945716858,
-0.12113887816667557,
0.2553596794605255,
-0.07479537278413773,
-0.0016161788953468204,
-0.13715612888336182,
-0.20687319338321686,
0.0353500060737133,
-0.1332722306251526,
-0.15606719255447388,
0.19037894904613495,
0.29625043272972107,
-0.10415677726268768,
0.0395873561501503,
-0.36879393458366394,
0.12042033672332764,
-0.0240738894790411,
0.03216547518968582,
-0.08859661221504211,
0.033334534615278244,
-0.13198409974575043,
-0.03288552165031433,
-0.183927983045578,
-0.1720452606678009,
-0.5299676060676575,
-0.0033230690751224756,
-0.11542563885450363,
0.1327609121799469,
-0.22308486700057983,
0.20314723253250122,
-0.032341208308935165,
0.3064368963241577,
-0.22143936157226562,
0.0057512433268129826,
-0.11406368762254715,
-0.18855677545070648,
0.17097854614257812,
0.1524147093296051,
-0.3721444010734558,
-0.3904537260532379,
0.09586350619792938,
0.2870025634765625,
-0.19614237546920776,
-0.1501665562391281,
-0.1257917881011963,
0.009822528809309006,
0.32063406705856323,
-0.12479478120803833,
-0.09871497750282288,
-0.19827012717723846,
-0.28877100348472595,
0.06420881301164627,
-0.1882839947938919,
0.12509694695472717,
0.2596220374107361,
0.255271315574646,
0.08714747428894043,
0.16973604261875153,
-0.052567258477211,
0.02141726389527321,
0.05592045560479164,
-0.011463009752333164,
0.016568224877119064,
0.1293053925037384,
-0.12152442336082458,
-0.03376279026269913,
-0.11576051265001297,
-0.20287710428237915,
0.09745799750089645,
0.02226158231496811,
-0.10478953272104263,
-0.2668704092502594,
0.04280611500144005,
0.13661956787109375,
-0.123647540807724,
-0.544232189655304,
0.05317307636141777,
0.23117585480213165,
-0.07886029034852982,
0.23462358117103577,
0.13409969210624695,
0.1533524990081787,
-0.34992116689682007,
0.4248571991920471,
-0.066624216735363,
-0.40286150574684143,
0.1695770025253296,
0.20636427402496338,
0.04406946897506714,
-0.3092534840106964,
-0.07699994742870331,
-0.5287734270095825,
0.020564328879117966,
-0.29403093457221985,
-0.10429783165454865,
0.09236273914575577,
-0.13639456033706665,
0.4420205354690552,
-0.12899571657180786,
0.018140612170100212,
0.19989097118377686,
-0.4393060505390167,
0.1586323082447052,
-0.004726284183561802,
0.2238311916589737,
-0.052582502365112305,
0.23350058495998383,
-0.14424896240234375,
-0.05433224141597748,
0.01453724130988121,
0.28455644845962524,
0.1393674612045288,
0.23071876168251038,
-0.02165723219513893,
-0.3429080545902252,
0.514430046081543,
-0.2316158562898636,
0.10780754685401917,
-0.1607195883989334,
0.11202799528837204,
-0.09162814170122147,
0.3874986469745636,
-0.02566186524927616,
-0.3703157603740692,
-0.30256187915802,
0.16924981772899628,
0.271154522895813,
0.22124727070331573,
0.16285967826843262,
0.2333436757326126,
0.0418970063328743,
0.44647395610809326,
-0.014870035462081432,
0.16180019080638885,
-0.1956024318933487,
0.2779575288295746,
0.027497541159391403,
0.12531490623950958,
-0.6982647180557251,
-0.24014447629451752,
-0.047450531274080276,
-0.06951171904802322,
0.11170179396867752,
-0.13222800195217133,
0.14191311597824097,
0.08441952615976334,
0.0039437031373381615,
0.16070376336574554,
-0.19121891260147095,
0.04984968528151512,
0.09552345424890518,
-0.13646720349788666,
0.1381131261587143,
-0.39091214537620544,
0.0037937606684863567,
0.14957180619239807,
0.10267537832260132,
-0.15263774991035461,
-0.06463520228862762,
0.05346694588661194,
0.05941417068243027,
0.256795197725296,
-0.18952125310897827,
-0.0767175629734993,
-0.013751254417002201,
0.10629849880933762,
0.05937790125608444,
0.18298721313476562,
0.34168392419815063,
-0.2795267105102539,
-0.11501388251781464,
-0.11160128563642502,
-0.29084014892578125,
-0.13619424402713776,
-0.3570435047149658,
0.15577775239944458,
0.04180450737476349,
-0.024661961942911148,
-0.14074654877185822,
-0.022999435663223267,
0.12797774374485016,
-0.07162272185087204,
-0.1759890764951706,
0.1161411702632904,
0.010054387152194977,
0.06701923906803131,
-0.07419747859239578,
0.11269461363554001,
-0.21367771923542023,
0.030607400462031364,
-0.14954465627670288,
-0.06736898422241211,
0.044916462153196335,
0.212850883603096,
-0.08457478880882263,
0.04819049686193466,
0.2948461174964905,
-0.2229093313217163,
0.11812106519937515,
-0.21492727100849152,
0.10085665434598923,
-0.21724730730056763,
0.030533364042639732,
0.15471476316452026,
-0.16590465605258942,
0.1564759612083435,
0.30255988240242004,
-0.050714801996946335,
0.04854338616132736,
0.15203219652175903,
-0.20404550433158875,
-0.08470220118761063,
0.1252981424331665,
-0.27740412950515747,
-0.40458670258522034,
0.028981341049075127,
-0.14198994636535645,
-0.15722954273223877,
0.12342418730258942,
0.019912829622626305,
0.20157214999198914,
0.008920861408114433,
-0.4127655327320099,
-0.39422380924224854,
0.2587372064590454,
-0.26439401507377625,
0.15267543494701385,
-0.5782222151756287,
-0.15670470893383026,
-0.16834336519241333,
0.15854065120220184,
0.13130488991737366,
0.04896985739469528,
-0.1057291105389595,
-0.06031171604990959,
-0.3087310194969177,
-0.1763349324464798,
0.014983699657022953,
0.14902369678020477,
-0.1925804316997528,
-0.022864356637001038,
-0.43683117628097534,
-0.24058720469474792,
0.20332327485084534,
0.05634823068976402,
-0.24122829735279083,
-0.2136271893978119,
0.24016237258911133,
0.13229577243328094,
0.10123944282531738,
0.08358017355203629,
-0.07313859462738037,
-0.04764971137046814,
-0.26146814227104187,
-0.08427821844816208,
-0.08586876094341278,
0.05484014376997948,
0.0978013277053833,
0.1351233869791031,
0.3011326789855957,
0.08919982612133026,
-0.1413985937833786,
-0.20668475329875946,
0.15219220519065857,
0.17307984828948975,
-0.10279041528701782,
-0.016069134697318077,
-0.4236554205417633,
0.5427110195159912,
-0.13459278643131256,
0.05308721959590912,
0.22161421179771423,
0.1774793565273285,
-0.2590223550796509,
-0.027760036289691925,
-0.05625274032354355,
0.16174592077732086,
-0.12131017446517944,
0.23195280134677887,
-0.2879922389984131,
-0.17104819416999817,
-0.09668369591236115,
-0.10803189873695374,
-0.03763397037982941,
0.00549035519361496,
-0.21991737186908722,
0.2780084013938904,
-0.11470634490251541,
0.2270844280719757,
0.09355523437261581,
-0.31679242849349976,
-0.3052532374858856,
0.21996109187602997,
-0.1334264725446701,
-0.10961861163377762,
0.16555196046829224,
0.20092065632343292,
-0.048446349799633026,
0.03118588775396347,
-0.23408254981040955,
-0.16460196673870087,
0.034022923558950424,
-0.0616418682038784,
0.4102761745452881,
0.14840789139270782,
0.08061337471008301,
0.28417134284973145,
-0.015525353141129017,
-0.09809930622577667,
0.017871100455522537,
-0.06626497209072113,
-0.31379979848861694,
-0.05554937198758125,
-0.30488699674606323,
-0.06306285411119461,
-0.09749455749988556,
-0.13379833102226257,
0.31094253063201904,
0.25933557748794556,
-0.2099885791540146,
-0.13271686434745789,
0.47425955533981323,
-0.03348473459482193,
0.40389299392700195,
0.2987373173236847,
0.02759440429508686,
-0.08062521368265152,
0.3046666979789734,
-0.3716556429862976,
-0.04997577518224716,
-0.26123490929603577,
-0.04062681645154953,
0.033948179334402084,
0.05190528556704521,
0.3114664852619171,
-0.02518656849861145,
-0.02207990735769272,
-0.17261038720607758,
0.16430197656154633,
-0.15436850488185883,
-0.19642600417137146,
0.3711506128311157,
-0.08813926577568054,
-0.14507214725017548,
0.11275292932987213,
0.274177223443985,
0.05396625027060509,
-0.3930492699146271,
-0.036507703363895416,
0.017722811549901962,
-0.051422204822301865,
-0.10763843357563019,
-0.1826823353767395,
-0.013523652218282223,
0.2589273452758789,
0.11355141550302505,
0.26801055669784546,
0.0686066672205925,
0.3060219883918762,
0.26130130887031555,
-0.021280307322740555,
0.029642334207892418,
0.035256482660770416,
-0.17850922048091888,
-0.0033023350406438112,
-0.19141127169132233,
-0.002746335929259658,
-0.05963689461350441,
-0.001230032299645245,
-0.014096060767769814,
0.11954555660486221,
-0.06062743812799454,
0.19642646610736847,
0.18764381110668182,
0.24669316411018372,
0.23066173493862152,
-0.4589255750179291,
-0.04140579700469971,
-0.045448437333106995,
0.18735674023628235,
0.2035721391439438,
0.11091016232967377,
0.24520976841449738,
-0.031982216984033585,
-0.05159139633178711,
-0.14669112861156464,
0.14334657788276672,
0.13942444324493408,
0.21692180633544922,
0.2477506399154663,
-0.04444989934563637,
-0.004300503060221672,
0.18927712738513947,
0.025019077584147453,
0.10276179760694504,
-0.015157420188188553,
-0.11342436075210571,
0.041876837611198425,
0.016302844509482384,
-0.08735167235136032,
-0.01832830160856247,
-0.1605042666196823,
-0.17140315473079681,
-0.17564880847930908,
0.3026584982872009,
0.22814258933067322,
-0.18345722556114197,
0.011379492469131947,
0.36575090885162354,
0.13595952093601227,
-0.02774905040860176,
-0.16523464024066925,
-0.10615754872560501,
0.07623521983623505,
-0.13823699951171875,
0.14095139503479004,
0.14118456840515137,
0.23550985753536224,
0.049236100167036057,
-0.1238374263048172,
-0.1450912058353424,
0.03514942526817322,
-0.05403243377804756,
-0.3122042715549469,
0.1396409422159195,
-0.1631166785955429,
-0.27591145038604736,
0.27685752511024475,
-0.040022850036621094,
-0.16783730685710907,
-0.08812149614095688,
-0.22129108011722565,
0.274206280708313,
0.2640330493450165,
0.19984610378742218,
0.1361813098192215,
0.32131311297416687,
0.25818386673927307,
-0.044523634016513824,
0.08542685210704803,
-0.012119992636144161,
0.24685975909233093,
-0.2166292518377304,
0.004241540562361479,
0.08692426234483719,
0.08331490308046341,
-0.31976959109306335,
-0.2031620740890503,
0.04504638910293579,
0.21867093443870544,
-0.16738246381282806,
-0.24402442574501038,
0.1833816021680832,
-0.11042196303606033,
-0.06881853193044662,
0.11283200979232788,
-0.21912112832069397,
-0.056700654327869415,
0.038113199174404144,
-0.0559997633099556,
-0.1424420028924942,
-0.17775970697402954,
0.16575570404529572,
-0.06401990354061127,
-0.1137319877743721,
0.21305149793624878,
0.22654663026332855,
0.1779865175485611,
-0.009250948205590248,
0.030365359038114548,
-0.20417769253253937,
-0.2933337390422821,
0.06429945677518845,
0.005587938707321882,
-0.08005514740943909,
0.26593467593193054,
0.09687838703393936,
0.10632644593715668,
0.1207657977938652,
0.09589173644781113,
0.5245772004127502,
-0.20957066118717194,
-0.08233224600553513,
-0.041510000824928284,
0.01955891214311123,
0.07060043513774872,
-0.007561811245977879,
-0.08146558701992035,
-0.14167766273021698,
-0.1798325926065445,
0.054622992873191833,
0.025139467790722847,
0.22969277203083038,
-0.19960913062095642,
-0.09262800961732864,
0.005403256509453058,
0.4101414978504181,
-0.0359673835337162,
0.0774480476975441,
0.18753495812416077,
-0.1511611044406891,
0.05408249422907829,
-0.3119370639324188,
0.2298576980829239,
0.3434966802597046,
-0.051773857325315475,
-0.3590735197067261,
-0.0835038498044014,
-0.19850648939609528,
0.2100358009338379,
-0.1064707487821579,
0.07713854312896729,
-0.04572899639606476,
0.03152471408247948,
0.28136515617370605,
0.07676934450864792,
-0.1606336236000061,
0.08151169121265411,
-0.15024180710315704,
-0.22758209705352783,
-0.04235409200191498,
0.222392275929451,
-0.21716463565826416,
-0.0005442555411718786,
-0.10384804755449295,
-0.05319131538271904,
0.11200437694787979,
0.022153692319989204,
-0.2671544849872589,
0.19073611497879028,
-0.1012914851307869,
-0.6100217700004578,
0.29198363423347473,
0.06557054072618484,
0.032519202679395676,
0.07061457633972168,
-0.14226321876049042,
-0.10142746567726135,
-0.08381257951259613,
0.021421557292342186,
0.0350487120449543,
0.17101192474365234,
-0.2001376748085022,
-0.07717171311378479,
-0.4049344062805176,
-0.09141746163368225,
-0.17839795351028442,
-0.012587039731442928,
-0.11531543731689453,
-0.26281291246414185,
0.16362281143665314,
-0.11315983533859253,
0.13030734658241272,
-0.2690817415714264,
0.11880124360322952,
-0.16857734322547913,
-0.3464515507221222,
0.04539923742413521,
-0.10826576501131058,
-0.11865193396806717,
-0.24502159655094147,
-0.01958022639155388,
0.18123212456703186,
-0.16508354246616364,
-0.5193576216697693,
-0.01697515696287155,
0.06728238612413406,
-0.03594014048576355,
-0.2172652781009674,
0.18519815802574158,
-0.091101735830307,
-0.04317311942577362,
-0.03541320562362671,
0.14119771122932434,
0.02380136214196682,
0.292034387588501,
-0.35773375630378723,
0.012735357508063316,
-0.22526903450489044,
0.033894479274749756,
-0.00979282520711422,
0.11181347072124481,
-0.2692272365093231,
0.13980603218078613,
0.11455246061086655,
0.4207380712032318,
0.1753837913274765,
0.33891040086746216,
0.24723871052265167,
-0.0994706079363823,
-0.3368222117424011,
-0.1122942864894867,
0.2098148614168167,
0.3212936222553253,
-0.23575881123542786,
-0.17048600316047668,
-0.08140983432531357,
0.04922276362776756,
-0.03497576341032982,
0.04896227642893791,
0.019240425899624825,
-0.14788156747817993,
-0.004315984435379505,
0.16945390403270721,
0.1045033261179924,
0.22072391211986542,
-0.12298016250133514,
0.456463098526001,
-0.05569130554795265,
0.1674831062555313,
-0.05421389266848564,
-0.22072800993919373,
0.1766199916601181,
0.1500587910413742,
-0.10466540604829788,
-0.07413025200366974,
-0.11136973649263382,
0.3172539174556732,
0.1458926498889923,
-0.4084663391113281,
-0.00827812310308218,
-0.19788911938667297,
0.05301898345351219,
0.18342892825603485,
-0.13290716707706451,
-0.137080118060112,
0.18817967176437378,
0.02599741332232952,
0.12464059144258499,
-0.1817694902420044,
0.13002291321754456,
-0.2058485895395279,
0.18554577231407166,
-0.2455490529537201,
-0.3552171289920807,
-0.07841368764638901,
-0.2629839777946472,
0.16071085631847382,
-0.14219802618026733,
0.05252198129892349,
-0.05912123993039131,
0.28019121289253235,
-0.13522347807884216,
0.1113814264535904,
-0.19321133196353912,
0.36605358123779297,
-0.4223937690258026,
-0.0007286841282621026,
-0.09721998870372772,
0.2570018470287323,
-0.08545113354921341,
-0.03256983309984207,
0.30018720030784607,
0.3476523458957672,
-0.13697263598442078,
0.07407987117767334,
-0.25609704852104187,
-0.15611031651496887,
-0.19690769910812378,
-0.05442740395665169,
0.19068939983844757,
0.28131985664367676,
-0.1672075241804123,
-0.4596557319164276,
0.3426617980003357,
0.1413952261209488,
0.49465298652648926,
0.3015539050102234,
-0.3896936774253845,
-0.2348848432302475,
-0.1128779798746109,
0.08168231695890427,
0.2873814105987549,
0.04154157638549805,
0.02403130754828453,
0.04535748064517975,
-0.29568561911582947,
0.052050381898880005,
-0.06587878614664078,
0.28595423698425293,
0.15254636108875275,
0.04214509204030037,
0.09150625765323639,
0.4472195506095886,
-0.27832871675491333,
-0.30263641476631165,
-0.003304495709016919,
-0.1683770716190338,
0.22562749683856964,
0.020146729424595833,
0.31872978806495667,
-0.29566726088523865,
-0.1747010499238968,
-0.005297576077282429,
0.024705102667212486,
0.10150112211704254,
-0.25093334913253784,
-0.1533234417438507,
-0.09111829847097397,
-0.2595844864845276,
0.3223245143890381,
-0.1214752271771431,
0.3616592288017273,
-0.14364635944366455,
0.05057486146688461,
-0.07154862582683563,
-0.2996149957180023,
-0.10575834661722183,
0.2071293294429779,
-0.058154720813035965,
0.011873614974319935,
0.03362227976322174,
0.16026027500629425,
-0.19674433767795563,
-0.03539200499653816,
0.04273591935634613,
0.03368311747908592,
-0.4159868657588959,
0.057329561561346054,
-0.41070786118507385,
-0.21263563632965088,
-0.020745187997817993,
-0.006536385975778103,
-0.047098513692617416,
0.04316259175539017,
-0.11591019481420517,
-0.2925284206867218,
-0.14942993223667145,
0.20001177489757538,
0.2643163204193115,
-0.24492822587490082,
-0.08404821157455444,
0.2709631323814392,
0.02090555615723133,
-0.38279104232788086,
0.013964866288006306,
-0.05860136076807976,
0.07755406200885773,
0.3059522807598114,
-0.11588780581951141,
-0.08712761104106903,
0.02078087255358696,
0.0026575529482215643,
-0.015275283716619015,
-0.06237037107348442,
0.12412294745445251,
-0.3333198130130768,
-0.26374801993370056,
0.12548495829105377,
0.19966021180152893,
0.143803209066391,
0.17684847116470337,
0.2945772409439087,
0.2592507004737854,
0.2500334680080414
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. 1. Metabolic pathway. Propionyl-CoA carboxylase (PCC) catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA, which enters the Krebs cycle via succinyl-CoA. Sources of propionate include: valine, isoleucine, threonine, methionine, odd-chain fatty (more...)Biochemical findings in propionic acidemia include:Plasma acylcarnitine profile: elevated propionylcarnitine (C3)Urine organic acids:Elevated 3-hydroxypropionatePresence of:MethylcitrateTiglylglycinePropionylglycineLactic acidPlasma amino acids: elevated glycineCommon laboratory abnormalities during acute decompensation include:High-anion gap metabolic acidosisLactic acidosisElevated plasma and urinary ketonesLow to normal blood glucose concentrationHyperammonemiaNeutropenia, anemia, and thrombocytopeniaEstablishing the DiagnosisIn a proband who has the clinical, laboratory, and biochemical findings reviewed above and in Figure 2, the diagnosis of PA is established using | [
-0.17661342024803162,
-0.17621387541294098,
-0.13508683443069458,
-0.2632574439048767,
0.09607630968093872,
0.14408496022224426,
0.022454826161265373,
-0.15829721093177795,
0.06067373976111412,
-0.29573971033096313,
0.24326913058757782,
0.05234938859939575,
-0.08480507880449295,
-0.18548670411109924,
-0.2888597548007965,
0.2835056483745575,
-0.055872052907943726,
0.02807827852666378,
-0.15805619955062866,
-0.17751264572143555,
0.04614240676164627,
-0.17820876836776733,
-0.19398552179336548,
0.13064295053482056,
0.2924218475818634,
-0.18513742089271545,
0.08250603824853897,
-0.3131791055202484,
0.13617733120918274,
-0.025919055566191673,
-0.00845407135784626,
-0.055549606680870056,
0.207392156124115,
-0.1882178634405136,
-0.13403980433940887,
-0.243411123752594,
-0.20493721961975098,
-0.6139324903488159,
0.026368772611021996,
-0.13933104276657104,
0.23744447529315948,
-0.22977006435394287,
0.28116917610168457,
0.00777954189106822,
0.21037907898426056,
-0.1620442122220993,
0.008942732587456703,
-0.171904519200325,
-0.19739611446857452,
0.23871657252311707,
0.18738675117492676,
-0.32494840025901794,
-0.42764246463775635,
0.11829783767461777,
0.22216543555259705,
-0.26202672719955444,
-0.1548251360654831,
-0.14454375207424164,
-0.0930493026971817,
0.2797395586967468,
-0.05303036794066429,
-0.09554354846477509,
-0.19044086337089539,
-0.2926499843597412,
0.18124589323997498,
-0.29423078894615173,
0.04890068620443344,
0.26917821168899536,
0.17524540424346924,
0.09682899713516235,
0.1629977971315384,
-0.005417338572442532,
0.02578597702085972,
0.13232284784317017,
-0.018362682312726974,
-0.045532677322626114,
0.18269304931163788,
-0.2738771140575409,
0.02198098972439766,
-0.18956713378429413,
-0.2050691545009613,
0.14270231127738953,
0.04770680516958237,
-0.09891816228628159,
-0.27281397581100464,
0.012912565842270851,
0.12156864255666733,
-0.14015430212020874,
-0.46906667947769165,
0.023952381685376167,
0.23644596338272095,
0.07069991528987885,
0.2001226395368576,
0.152462899684906,
0.08874756842851639,
-0.4053874611854553,
0.3690641224384308,
-0.11594192683696747,
-0.331270694732666,
0.10878045856952667,
0.19467519223690033,
0.11545148491859436,
-0.31039413809776306,
-0.09868551790714264,
-0.5013988018035889,
0.04295247793197632,
-0.2641214430332184,
-0.09175989031791687,
0.011839858256280422,
-0.0907038003206253,
0.34896382689476013,
-0.052863940596580505,
0.20025984942913055,
0.20287813246250153,
-0.5087628960609436,
0.05529194697737694,
-0.04130201041698456,
0.23839692771434784,
0.03942180052399635,
0.19414441287517548,
-0.07138365507125854,
-0.04166974127292633,
0.03826373070478439,
0.21187685430049896,
0.04120538756251335,
0.18834801018238068,
-0.10146844387054443,
-0.38149937987327576,
0.4351365566253662,
-0.17191003262996674,
0.04208122566342354,
-0.057505566626787186,
0.07175211608409882,
-0.1425705999135971,
0.4034956991672516,
-0.024477794766426086,
-0.2866518497467041,
-0.22951972484588623,
0.10872253030538559,
0.26727768778800964,
0.20817424356937408,
0.1735222190618515,
0.3144269287586212,
0.09697755426168442,
0.3480369448661804,
0.024954576045274734,
0.1765381544828415,
-0.16756108403205872,
0.25109273195266724,
0.04807068035006523,
0.0637446865439415,
-0.6156617403030396,
-0.3197786808013916,
0.009652028791606426,
-0.10949792712926865,
0.16759568452835083,
-0.018295878544449806,
0.26163506507873535,
0.10256757587194443,
0.06229138374328613,
0.11440145969390869,
-0.09349658340215683,
-0.04079200699925423,
0.1095021665096283,
-0.14104950428009033,
0.15334607660770416,
-0.46158790588378906,
0.013862716034054756,
0.04974794387817383,
0.009119485504925251,
-0.12296316027641296,
-0.13838036358356476,
-0.03500711917877197,
-0.02325279265642166,
0.31857001781463623,
-0.08635573834180832,
-0.010818556882441044,
-0.0017313244752585888,
0.09340810775756836,
0.23507627844810486,
0.1941232681274414,
0.3071652054786682,
-0.2368563413619995,
-0.059036754071712494,
-0.22389236092567444,
-0.25438806414604187,
-0.11930648237466812,
-0.26718756556510925,
0.15116997063159943,
0.04308837652206421,
0.08466780185699463,
-0.06518608331680298,
0.0355871319770813,
0.1428404301404953,
0.07377370446920395,
-0.13351517915725708,
0.11677197366952896,
0.0363953672349453,
0.10141001641750336,
-0.15118356049060822,
0.0775810182094574,
-0.3069568872451782,
0.042161572724580765,
-0.1762969195842743,
-0.008692334406077862,
-0.04059522598981857,
0.20031113922595978,
-0.10028693079948425,
0.08210494369268417,
0.276252418756485,
-0.2318042367696762,
0.16934341192245483,
-0.30663061141967773,
0.009686759673058987,
-0.21633045375347137,
-0.020020952448248863,
0.05385048687458038,
-0.16684158146381378,
0.15005391836166382,
0.4043690264225006,
-0.09983434528112411,
0.144291490316391,
0.1464301198720932,
-0.2968205511569977,
-0.0906398817896843,
0.05326716601848602,
-0.38588088750839233,
-0.44027140736579895,
0.00873345322906971,
-0.23353798687458038,
-0.19841496646404266,
0.1321513056755066,
0.04232753813266754,
0.2556770443916321,
-0.14249718189239502,
-0.4113016426563263,
-0.3903086185455322,
0.2947705090045929,
-0.1588517278432846,
0.13159333169460297,
-0.4260615110397339,
-0.10164874792098999,
-0.13079939782619476,
0.08340129256248474,
0.08153337985277176,
0.16807860136032104,
-0.06275565177202225,
-0.14087897539138794,
-0.3550511300563812,
-0.005259500350803137,
-0.018336091190576553,
0.17277416586875916,
-0.16387411952018738,
-0.05664549022912979,
-0.36556240916252136,
-0.2591588497161865,
0.2872735559940338,
0.02776009403169155,
-0.26744478940963745,
-0.24294047057628632,
0.13845963776111603,
0.10133631527423859,
0.16356685757637024,
0.15325647592544556,
-0.020791780203580856,
-0.10676482319831848,
-0.2745775878429413,
-0.059530485421419144,
-0.13436849415302277,
-0.06308017671108246,
0.06141546368598938,
0.15780551731586456,
0.3063076436519623,
0.05220996215939522,
-0.2264617532491684,
-0.19899019598960876,
0.25052785873413086,
0.12503233551979065,
-0.15484358370304108,
0.10143159329891205,
-0.26624274253845215,
0.6184074878692627,
-0.09923527389764786,
-0.006834456231445074,
0.27363118529319763,
0.10588690638542175,
-0.2849521338939667,
-0.01982206292450428,
-0.031716927886009216,
0.12090745568275452,
-0.0639747679233551,
0.18864692747592926,
-0.15582938492298126,
-0.11324318498373032,
0.033277783542871475,
-0.003952610772103071,
-0.06465276330709457,
-0.000915725075174123,
-0.16559480130672455,
0.3022969663143158,
-0.0711151510477066,
0.215981587767601,
0.11965431272983551,
-0.365861713886261,
-0.3325376808643341,
0.13475243747234344,
-0.08604327589273453,
-0.17390598356723785,
0.25572845339775085,
0.1653728038072586,
0.03666031360626221,
-0.002144779544323683,
-0.3200847804546356,
-0.11390490084886551,
-0.046754080802202225,
-0.044112443923950195,
0.35071802139282227,
0.09480153769254684,
0.012981300242245197,
0.2215362787246704,
-0.05807529762387276,
-0.05896013602614403,
-0.0022811535745859146,
-0.0257642213255167,
-0.31077826023101807,
-0.0750337764620781,
-0.2691475450992584,
-0.11241498589515686,
-0.09278006106615067,
-0.08547497540712357,
0.27651238441467285,
0.30589208006858826,
-0.0937291830778122,
-0.16072483360767365,
0.4628831148147583,
-0.08517326414585114,
0.3906666040420532,
0.23702384531497955,
-0.04971066117286682,
-0.041096340864896774,
0.2615925371646881,
-0.4759189188480377,
0.039325494319200516,
-0.1789720058441162,
-0.051301874220371246,
-0.0858994647860527,
0.03908611088991165,
0.3553612530231476,
0.008423266001045704,
-0.07372743636369705,
-0.13154564797878265,
0.2011406123638153,
-0.13734307885169983,
-0.14754626154899597,
0.30792930722236633,
-0.1562470644712448,
-0.17797185480594635,
0.08615949004888535,
0.2035105973482132,
0.05385182052850723,
-0.35923850536346436,
0.08186504244804382,
-0.09118770807981491,
-0.13629058003425598,
-0.11593657732009888,
-0.12721474468708038,
-0.05678113177418709,
0.2339114397764206,
0.23184898495674133,
0.10391043871641159,
0.0897800549864769,
0.35657745599746704,
0.20413023233413696,
0.08952664583921432,
-0.06828902661800385,
0.09543062746524811,
0.008019394241273403,
0.0057174451649188995,
-0.30212298035621643,
-0.06454525887966156,
0.05061575770378113,
0.009518533013761044,
-0.05880826711654663,
0.09062495827674866,
-0.004094412084668875,
0.1657358705997467,
0.04770483449101448,
0.22497229278087616,
0.1835043579339981,
-0.5037494897842407,
0.055317241698503494,
0.016360385343432426,
0.17111046612262726,
0.18446409702301025,
0.1018613874912262,
0.264873206615448,
0.09933948516845703,
0.06336243450641632,
-0.052563391625881195,
0.13495862483978271,
0.1805436611175537,
0.15727442502975464,
0.2748263478279114,
0.05475802347064018,
0.043008510023355484,
0.15490733087062836,
0.059215374290943146,
0.11119572818279266,
-0.003736331593245268,
-0.02293829806149006,
-0.03443063795566559,
-0.09504875540733337,
-0.003064752323552966,
-0.004381055012345314,
-0.055271971970796585,
-0.10145225375890732,
-0.20486783981323242,
0.26809126138687134,
0.2333812713623047,
-0.2123418003320694,
0.06476716697216034,
0.33156758546829224,
0.12305974215269089,
-0.03264596685767174,
-0.10708588361740112,
-0.11300066113471985,
0.02240249328315258,
-0.09285983443260193,
0.09484341740608215,
0.14004066586494446,
0.31645825505256653,
0.027718624100089073,
-0.07677499204874039,
-0.16299797594547272,
-0.02953694574534893,
-0.01177375391125679,
-0.3080928325653076,
0.08976075798273087,
-0.19364260137081146,
-0.3327246308326721,
0.26380082964897156,
-0.04264306649565697,
-0.21888791024684906,
0.019393842667341232,
-0.27073416113853455,
0.26442471146583557,
0.3468836545944214,
0.30448633432388306,
0.07536496222019196,
0.2774454355239868,
0.3156163990497589,
-0.08046120405197144,
0.10031558573246002,
-0.03178493306040764,
0.26345452666282654,
-0.1608748733997345,
0.06604773551225662,
0.02613452449440956,
0.06537210196256638,
-0.20872877538204193,
-0.28376731276512146,
0.15835466980934143,
0.2837355434894562,
-0.22938452661037445,
-0.22591479122638702,
0.20069201290607452,
-0.24186034500598907,
-0.044973816722631454,
0.06696049124002457,
-0.09942975640296936,
-0.06695184111595154,
0.10976755619049072,
0.10559164732694626,
-0.13476082682609558,
-0.23695959150791168,
0.13127771019935608,
0.021390724927186966,
-0.09672670811414719,
0.15477120876312256,
0.22899757325649261,
0.1929706484079361,
-0.1500001847743988,
0.11661247164011002,
-0.23693543672561646,
-0.2527362108230591,
0.1777176558971405,
-0.04653037339448929,
-0.005372117273509502,
0.29723507165908813,
0.0597936287522316,
0.1877492070198059,
0.1719633787870407,
0.04618081450462341,
0.5633620619773865,
-0.23039887845516205,
-0.10102085024118423,
0.004299741238355637,
-0.018237866461277008,
-0.044813137501478195,
0.005695896223187447,
-0.152520090341568,
-0.18850994110107422,
-0.1279214322566986,
0.06867515295743942,
-0.10311003029346466,
0.2311907410621643,
-0.2132614403963089,
-0.018654171377420425,
-0.07063063234090805,
0.4326014816761017,
0.04171283543109894,
0.16070027649402618,
0.23788602650165558,
-0.29981231689453125,
0.11778822541236877,
-0.2660718560218811,
0.2140892595052719,
0.3910068869590759,
-0.014949629083275795,
-0.4598293602466583,
-0.06477134674787521,
-0.19814704358577728,
0.21107515692710876,
-0.057153817266225815,
0.13617126643657684,
-0.1287687122821808,
0.06216111406683922,
0.26150986552238464,
0.044570762664079666,
-0.13266614079475403,
0.06275933980941772,
-0.14810435473918915,
-0.21960444748401642,
-0.057012010365724564,
0.20525336265563965,
-0.11671819537878036,
-0.06669847667217255,
-0.15178848803043365,
-0.0032759823370724916,
0.09823880344629288,
0.06462685018777847,
-0.24830734729766846,
0.2001839131116867,
-0.206782266497612,
-0.5947367548942566,
0.3962612748146057,
0.17691288888454437,
0.12162704020738602,
0.18000543117523193,
-0.20238061249256134,
-0.10228705406188965,
-0.1271732747554779,
0.10164404660463333,
-0.008998448960483074,
0.06646893173456192,
-0.10821445286273956,
-0.22952041029930115,
-0.4257602095603943,
-0.1556818038225174,
-0.09443522989749908,
-0.05271581932902336,
-0.12307342141866684,
-0.23591357469558716,
0.23650160431861877,
-0.06364820152521133,
0.051568396389484406,
-0.2045566588640213,
0.0978303924202919,
-0.24349923431873322,
-0.3819548189640045,
0.037754084914922714,
-0.04219219088554382,
-0.098825603723526,
-0.2805830240249634,
-0.04272975027561188,
0.15503224730491638,
-0.06655208021402359,
-0.4761480987071991,
-0.061913248151540756,
0.11972817033529282,
-0.1114271953701973,
-0.24346578121185303,
0.2870582938194275,
-0.08467524498701096,
-0.0968998372554779,
-0.006201630923897028,
0.15284308791160583,
0.10168290883302689,
0.35926368832588196,
-0.31640172004699707,
-0.07516177743673325,
-0.25545090436935425,
0.03911730647087097,
-0.05762017145752907,
0.1846780925989151,
-0.22634628415107727,
0.17142051458358765,
0.055403463542461395,
0.36317798495292664,
0.16386710107326508,
0.376701682806015,
0.17136572301387787,
-0.007577443029731512,
-0.29754146933555603,
-0.17520272731781006,
0.22374227643013,
0.313752144575119,
-0.22653378546237946,
-0.10069055110216141,
0.017942043021321297,
-0.06443849951028824,
-0.007124508731067181,
0.15503574907779694,
-0.03864850103855133,
-0.127895787358284,
-0.03156458958983421,
0.15085561573505402,
0.0797761082649231,
0.1447376310825348,
-0.11328370124101639,
0.44429492950439453,
-0.0573217049241066,
0.03172612935304642,
0.06965375691652298,
-0.23748522996902466,
0.1276564598083496,
0.1678062081336975,
-0.19756020605564117,
-0.010986031033098698,
-0.07006858289241791,
0.2881160080432892,
0.2796090543270111,
-0.37679779529571533,
-0.03650261461734772,
-0.22509406507015228,
0.06828626245260239,
0.19980476796627045,
-0.16156412661075592,
-0.18320944905281067,
0.23371554911136627,
-0.0837966650724411,
0.12093570828437805,
-0.23293064534664154,
0.17256778478622437,
-0.21135960519313812,
0.11750425398349762,
-0.15679553151130676,
-0.3751850724220276,
-0.018079541623592377,
-0.22483570873737335,
0.14344380795955658,
-0.21949881315231323,
0.1603720784187317,
0.018496066331863403,
0.36883601546287537,
-0.1689111739397049,
0.14538134634494781,
-0.16031710803508759,
0.3217780888080597,
-0.3856005370616913,
-0.0014184681931510568,
0.020628035068511963,
0.3251301944255829,
-0.005235695280134678,
-0.06579683721065521,
0.2639898955821991,
0.32742759585380554,
-0.10267052799463272,
0.08945948630571365,
-0.22354266047477722,
-0.2902648150920868,
-0.1652308851480484,
-0.0673445537686348,
0.16281162202358246,
0.1574656069278717,
-0.16647136211395264,
-0.3720969259738922,
0.439358115196228,
0.0942813828587532,
0.4863637387752533,
0.22391322255134583,
-0.3444989025592804,
-0.26707223057746887,
-0.02183099091053009,
0.09324362128973007,
0.28062573075294495,
-0.025936447083950043,
-0.03942408040165901,
0.04065368324518204,
-0.3751756250858307,
0.045008670538663864,
-0.10207702964544296,
0.3745845854282379,
-0.05949408933520317,
0.05763997510075569,
0.11033753305673599,
0.5093371868133545,
-0.19693517684936523,
-0.2790502607822418,
-0.02461577206850052,
-0.15306411683559418,
0.19477854669094086,
0.07391536235809326,
0.3039398491382599,
-0.21752403676509857,
-0.2134586125612259,
0.12205670028924942,
-0.007001880556344986,
0.09309206902980804,
-0.2905213236808777,
-0.11061105132102966,
-0.10075400769710541,
-0.2313591092824936,
0.36583778262138367,
-0.18533684313297272,
0.26486748456954956,
-0.13455452024936676,
0.13798241317272186,
-0.12217408418655396,
-0.30257728695869446,
-0.08307965099811554,
0.09468340128660202,
-0.007376971188932657,
-0.007562245242297649,
0.018740464001893997,
0.09946657717227936,
-0.22205811738967896,
0.03200451657176018,
0.023351553827524185,
0.06409282982349396,
-0.42880672216415405,
-0.010980552062392235,
-0.4788692593574524,
-0.1353418529033661,
-0.1322457194328308,
-0.12848229706287384,
0.0196393933147192,
-0.09730679541826248,
-0.13831597566604614,
-0.25932028889656067,
-0.17188072204589844,
0.26134273409843445,
0.28944820165634155,
-0.11869899928569794,
-0.13605260848999023,
0.2973598837852478,
0.11364905536174774,
-0.34324517846107483,
0.05580487102270126,
-0.1615314930677414,
0.13018083572387695,
0.36434099078178406,
-0.03311633691191673,
-0.023502983152866364,
0.05815852805972099,
0.021418604999780655,
-0.07412739098072052,
-0.051513854414224625,
0.052700724452733994,
-0.25648924708366394,
-0.1839098483324051,
0.04117594286799431,
0.01741034910082817,
0.04322708770632744,
0.062174294143915176,
0.3546566069126129,
0.3287155330181122,
0.2622446119785309
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. sence of:MethylcitrateTiglylglycinePropionylglycineLactic acidPlasma amino acids: elevated glycineCommon laboratory abnormalities during acute decompensation include:High-anion gap metabolic acidosisLactic acidosisElevated plasma and urinary ketonesLow to normal blood glucose concentrationHyperammonemiaNeutropenia, anemia, and thrombocytopeniaEstablishing the DiagnosisIn a proband who has the clinical, laboratory, and biochemical findings reviewed above and in Figure 2, the diagnosis of PA is established using the following strategies.Figure 2. Immediate management and testing algorithm to be pursued simultaneously after the clinical or laboratory suspicion of PA I. Identification of biallelic pathogenic variants in PCCA or PCCB on molecular genetic testing (see Table 1). Molecular testing approaches can include serial single-gene testing, use of a multigene panel, and more comprehensive
genomic testing:Serial single-gene testing can be considered if (1) mutation of a particular gene accounts for a large | [
-0.16224165260791779,
0.011090748943388462,
-0.09129440784454346,
-0.28318363428115845,
0.00848446972668171,
0.09335104376077652,
0.0755668431520462,
-0.17699362337589264,
-0.044660039246082306,
-0.11219803243875504,
0.15708352625370026,
0.0035976909566670656,
-0.0024545518681406975,
0.021921368315815926,
-0.27769044041633606,
0.20593512058258057,
0.13467100262641907,
-0.03237304091453552,
-0.0492074228823185,
0.008060223422944546,
0.11373963952064514,
-0.1394876390695572,
-0.08869844675064087,
0.14639149606227875,
0.2135748416185379,
-0.1234908327460289,
0.23811879754066467,
-0.25989410281181335,
0.0807141438126564,
0.02810053899884224,
-0.021016482263803482,
0.017094803974032402,
0.11156763881444931,
-0.22205820679664612,
-0.13594378530979156,
-0.2798091471195221,
-0.1508907675743103,
-0.25842636823654175,
0.10386496037244797,
-0.19856566190719604,
0.10921797901391983,
-0.12472164630889893,
0.33806905150413513,
-0.044401466846466064,
0.1564120501279831,
-0.03296590596437454,
0.04165826365351677,
-0.1282033771276474,
0.04283857345581055,
0.20772944390773773,
0.18562854826450348,
-0.09234824031591415,
-0.24515333771705627,
-0.19786225259304047,
0.2894362211227417,
-0.20776361227035522,
-0.18556293845176697,
-0.10161294788122177,
-0.19696058332920074,
-0.008794774301350117,
0.042158033698797226,
-0.022321553900837898,
-0.14196772873401642,
-0.2332765758037567,
0.19675195217132568,
-0.21460315585136414,
-0.08334332704544067,
0.15598399937152863,
0.13372933864593506,
-0.1006031408905983,
0.08694642782211304,
-0.06378396600484848,
0.04836443439126015,
0.06328234821557999,
-0.039609622210264206,
0.034893542528152466,
0.008927677758038044,
-0.07965073734521866,
0.03450469300150871,
-0.3859279155731201,
-0.2164638638496399,
-0.07025275379419327,
0.010121434926986694,
-0.06638259440660477,
-0.14434650540351868,
0.07984615117311478,
0.14044053852558136,
0.042735446244478226,
-0.008906226605176926,
0.09242112934589386,
0.12798917293548584,
0.0648220032453537,
-0.0036756691988557577,
-0.018219340592622757,
0.0756709948182106,
-0.23013530671596527,
0.13255047798156738,
0.05948544293642044,
-0.16602027416229248,
0.08800647407770157,
0.11574156582355499,
0.09004087746143341,
-0.15110592544078827,
-0.09818986058235168,
-0.020647205412387848,
0.061181794852018356,
-0.14581167697906494,
-0.032130248844623566,
-0.08664858341217041,
0.07012403011322021,
0.1521148979663849,
-0.07304418832063675,
0.09927135705947876,
-0.03935524448752403,
-0.39377835392951965,
-0.2013961225748062,
-0.01521274447441101,
0.31550994515419006,
0.07432056963443756,
0.07240862399339676,
-0.07059284299612045,
0.13533218204975128,
0.0653596743941307,
0.05556634068489075,
-0.057740792632102966,
-0.014375693164765835,
-0.10369361937046051,
-0.16199083626270294,
0.13522033393383026,
-0.10511748492717743,
0.09967716783285141,
0.19173912703990936,
0.07273812592029572,
-0.11094488948583603,
0.13291475176811218,
-0.16263088583946228,
-0.18807989358901978,
-0.30590736865997314,
-0.0591784343123436,
0.010813891887664795,
0.16158941388130188,
0.233796626329422,
0.19045068323612213,
0.2285999357700348,
0.05853024125099182,
0.12294583022594452,
0.282064825296402,
-0.14705890417099,
0.07971788942813873,
0.04488556087017059,
-0.010799314826726913,
-0.3258194625377655,
0.1208789050579071,
0.09626980125904083,
-0.05159619078040123,
0.13177502155303955,
0.11224356293678284,
0.3684973418712616,
-0.05729621648788452,
0.09520591050386429,
0.07432253658771515,
0.05608760565519333,
-0.004877102095633745,
-0.032574065029621124,
-0.055907998234033585,
-0.009162355214357376,
-0.26078274846076965,
0.07242339849472046,
-0.17793405055999756,
-0.11225822567939758,
-0.10298371315002441,
-0.05347652733325958,
0.03222024068236351,
0.1818409562110901,
0.16117484867572784,
0.12523072957992554,
-0.04631611704826355,
0.011743420735001564,
0.022451402619481087,
0.1506810486316681,
0.10634149610996246,
0.04436248168349266,
-0.31805142760276794,
-0.018490556627511978,
-0.22803179919719696,
-0.04663110896945,
0.1821237951517105,
0.06900201737880707,
0.006093282718211412,
0.21170920133590698,
0.12624453008174896,
-0.07370569556951523,
0.040174372494220734,
0.006502323318272829,
0.08373390138149261,
-0.09099814295768738,
-0.002228035358712077,
0.09261062741279602,
-0.03157434239983559,
-0.23275920748710632,
-0.09716639667749405,
-0.1534280776977539,
0.020046522840857506,
-0.11744079738855362,
0.038230109959840775,
-0.034109022468328476,
0.14338111877441406,
-0.10295777022838593,
0.09454341977834702,
0.015922827646136284,
-0.1486208140850067,
0.18797418475151062,
-0.31034064292907715,
0.07242142409086227,
-0.20061913132667542,
-0.17823027074337006,
0.055591072887182236,
-0.10385051369667053,
0.03888045623898506,
0.2519688904285431,
-0.08271203935146332,
0.05598372966051102,
0.10283470898866653,
-0.2428017556667328,
-0.018515434116125107,
-0.0012068870710209012,
-0.2621905505657196,
-0.10756494849920273,
0.11237781494855881,
-0.32909920811653137,
-0.04395728185772896,
-0.030127855017781258,
0.016909664496779442,
0.2403157353401184,
-0.21952158212661743,
-0.10078146308660507,
-0.20669375360012054,
0.22747495770454407,
0.0823521837592125,
0.021012544631958008,
-0.29992204904556274,
0.06448168307542801,
0.10407460480928421,
-0.023393558338284492,
0.07971537113189697,
0.13794998824596405,
-0.05578470230102539,
0.013347482308745384,
-0.06768669933080673,
0.2189154475927353,
0.058153197169303894,
0.08359821140766144,
-0.02277105115354061,
0.005837996024638414,
-0.2912566065788269,
-0.3222634196281433,
0.06888668239116669,
-0.0218115895986557,
0.048038359731435776,
0.006722619291394949,
-0.19428017735481262,
0.055133234709501266,
0.21577276289463043,
0.12453874945640564,
0.05130860581994057,
-0.03787262365221977,
-0.21270255744457245,
0.04075446352362633,
-0.1710546761751175,
-0.15938428044319153,
-0.05734085291624069,
0.1137639582157135,
0.16621151566505432,
0.07657665759325027,
-0.27941885590553284,
-0.07499296963214874,
0.08475559949874878,
0.09716278314590454,
-0.09329809248447418,
0.090608149766922,
-0.1577855944633484,
0.25030243396759033,
-0.10113082081079483,
0.04722363129258156,
0.17160432040691376,
0.051618289202451706,
0.008873315528035164,
0.025859996676445007,
-0.06360122561454773,
0.05429661273956299,
0.07895918935537338,
0.16108359396457672,
-0.0632263571023941,
-0.03413033485412598,
0.088035948574543,
0.17238253355026245,
-0.1176990270614624,
0.044513046741485596,
-0.025025151669979095,
0.04136630520224571,
0.1381129026412964,
0.12370260059833527,
0.11054785549640656,
-0.17596805095672607,
-0.3998498022556305,
-0.10942868888378143,
-0.06654061377048492,
-0.016739992424845695,
0.37560075521469116,
0.24603018164634705,
-0.05713190510869026,
-0.14317278563976288,
-0.2728331387042999,
0.04483845457434654,
-0.09749243408441544,
-0.03950121998786926,
0.008880021050572395,
0.037596747279167175,
0.10362672805786133,
0.1871187686920166,
-0.04828412085771561,
0.10077404975891113,
0.061981771141290665,
0.08522070944309235,
-0.23905745148658752,
-0.05630015954375267,
-0.15079164505004883,
0.016360020264983177,
-0.09919305145740509,
0.11221943795681,
0.09200098365545273,
0.12724564969539642,
0.011740519665181637,
-0.09823718667030334,
0.31811922788619995,
-0.1382005214691162,
0.24882912635803223,
-0.02043740823864937,
-0.12372433394193649,
0.11610784381628036,
0.1970982402563095,
-0.4317622184753418,
0.012089936062693596,
-0.0637403354048729,
-0.07763120532035828,
-0.03477722033858299,
0.014977507293224335,
0.07624083012342453,
0.13695724308490753,
-0.06341522186994553,
-0.07154226303100586,
0.006408107466995716,
0.021504051983356476,
-0.2943057417869568,
0.25149619579315186,
-0.09386753290891647,
0.06505662202835083,
0.20308877527713776,
0.06030198559165001,
0.14398860931396484,
-0.2664025127887726,
0.12284166365861893,
0.033876676112413406,
-0.18419808149337769,
0.09852438420057297,
-0.11653081327676773,
-0.0710107833147049,
0.07165549695491791,
0.28105613589286804,
-0.0013774256221950054,
0.1920839548110962,
0.1275886595249176,
0.08745190501213074,
0.16831278800964355,
-0.04775300994515419,
0.19890104234218597,
0.13611340522766113,
0.12236486375331879,
-0.29700514674186707,
-0.2599084675312042,
0.12939633429050446,
0.016193149611353874,
0.1002286747097969,
-0.016071567311882973,
0.043701864778995514,
0.17536616325378418,
-0.09782165288925171,
0.12127023935317993,
0.16700755059719086,
-0.44776850938796997,
0.10472331196069717,
0.06601680815219879,
-0.024976465851068497,
0.08846482634544373,
0.04911066219210625,
0.2139609307050705,
-0.017711937427520752,
0.06930620968341827,
0.03270009532570839,
-0.02138766273856163,
-0.03951593115925789,
-0.09951522946357727,
0.17566034197807312,
0.19585780799388885,
-0.017620794475078583,
-0.022689716890454292,
0.012788676656782627,
0.22181065380573273,
0.03455442562699318,
0.06197354570031166,
-0.0217311792075634,
-0.06220497190952301,
-0.04452046379446983,
-0.1460721641778946,
-0.06880971044301987,
-0.05088620260357857,
-0.210391104221344,
0.06494763493537903,
0.0780816450715065,
0.017330653965473175,
-0.03851370885968208,
0.09796987473964691,
0.09660342335700989,
-0.18146730959415436,
-0.1729833334684372,
0.048726171255111694,
0.013008810579776764,
-0.05133453384041786,
0.1025947853922844,
0.11777085065841675,
0.24285538494586945,
-0.0005882804980501533,
-0.16847455501556396,
-0.008139438927173615,
-0.012667854316532612,
0.06810760498046875,
-0.1475781947374344,
0.09189195930957794,
-0.03348565474152565,
-0.15367446839809418,
0.2043289840221405,
0.01093714777380228,
-0.0906059741973877,
0.09213881939649582,
-0.20689330995082855,
0.2156953662633896,
0.22539135813713074,
0.20486930012702942,
-0.012179496698081493,
0.12905235588550568,
0.19043639302253723,
-0.04252633452415466,
-0.11332284659147263,
-0.05813479796051979,
0.07262969762086868,
0.05623261630535126,
0.10067502409219742,
-0.1744322031736374,
-0.03559796139597893,
-0.07151249796152115,
-0.25022849440574646,
0.23557858169078827,
0.24140308797359467,
-0.016503730788826942,
-0.16297432780265808,
0.1436702162027359,
-0.18285709619522095,
0.0244949571788311,
0.08685851842164993,
0.08173306286334991,
0.02780485525727272,
0.19370317459106445,
0.057813674211502075,
0.07749678939580917,
-0.13325534760951996,
0.031819552183151245,
0.12290360033512115,
-0.08143866807222366,
-0.05853170529007912,
0.16659709811210632,
0.03509892523288727,
-0.2551459074020386,
0.13769255578517914,
-0.08442086726427078,
-0.02552284672856331,
0.15040579438209534,
-0.17783841490745544,
-0.0003149457916151732,
0.14666549861431122,
-0.10123150795698166,
0.07187937200069427,
0.12158426642417908,
-0.027237478643655777,
0.35208165645599365,
-0.10821084678173065,
-0.23633620142936707,
-0.10207708925008774,
-0.20170605182647705,
-0.07505476474761963,
0.09062952548265457,
-0.08613415062427521,
-0.02062940038740635,
0.044908568263053894,
0.03683033958077431,
-0.22394655644893646,
-0.035918716341257095,
-0.12081436067819595,
-0.11774890869855881,
0.007167488802224398,
0.2428465485572815,
-0.13568514585494995,
0.11403294652700424,
-0.030565381050109863,
-0.04224327579140663,
0.025821836665272713,
-0.32964643836021423,
0.0513848215341568,
0.2672813832759857,
-0.00905376486480236,
-0.12332430481910706,
0.08565744757652283,
-0.10007618367671967,
0.16242820024490356,
-0.04703354835510254,
0.12402181327342987,
-0.11925092339515686,
0.032894209027290344,
0.18716245889663696,
-0.029642222449183464,
-0.10588986426591873,
0.03919389471411705,
-0.1257912963628769,
-0.08503283560276031,
0.0786549299955368,
0.21338647603988647,
0.07153540104627609,
-0.036462970077991486,
-0.12252036482095718,
-0.19931578636169434,
-0.0013697141548618674,
-0.07645224779844284,
-0.08635333180427551,
0.08378155529499054,
-0.09412503242492676,
-0.23508283495903015,
0.27689507603645325,
0.19407549500465393,
0.12663881480693817,
0.14825980365276337,
-0.0038458534982055426,
-0.06878522038459778,
-0.21117010712623596,
0.08622179180383682,
0.025348970666527748,
-0.06738675385713577,
-0.06790110468864441,
-0.10881900787353516,
-0.13296419382095337,
-0.19059909880161285,
0.051400940865278244,
-0.06616169214248657,
-0.12259812653064728,
-0.19358468055725098,
-0.04726844280958176,
-0.005105181597173214,
0.11469592899084091,
-0.0369301363825798,
-0.17612692713737488,
-0.08613117784261703,
-0.07257312536239624,
-0.025119516998529434,
0.051361847668886185,
0.15075580775737762,
-0.13283537328243256,
-0.09400127083063126,
0.12356587499380112,
-0.12294921278953552,
-0.2958753705024719,
-0.15245835483074188,
0.010178119875490665,
0.006250361911952496,
-0.22977320849895477,
0.10482749342918396,
-0.10803256183862686,
0.05010681971907616,
0.04821699112653732,
0.008855283260345459,
0.05940181016921997,
0.19342006742954254,
-0.09910029172897339,
-0.10809587687253952,
-0.15997950732707977,
-0.005324983969330788,
0.05385032668709755,
0.11520589888095856,
-0.18815977871418,
0.24261409044265747,
-0.148474782705307,
-0.0241512730717659,
-0.004423878621309996,
0.11645680665969849,
0.11559469252824783,
0.06901185214519501,
-0.18981380760669708,
-0.09509303420782089,
-0.09880650788545609,
0.17437833547592163,
-0.28984004259109497,
0.025395849719643593,
0.038375552743673325,
0.09135644137859344,
-0.05022788420319557,
0.21957629919052124,
-0.017609847709536552,
-0.014208054170012474,
0.044752027839422226,
0.24417313933372498,
-0.15133340656757355,
0.2215101569890976,
-0.09510625898838043,
0.25322434306144714,
-0.026743339374661446,
0.020053265616297722,
-0.13534559309482574,
-0.1414411962032318,
0.023309461772441864,
0.018843874335289,
-0.08158137649297714,
-0.002325979294255376,
-0.144196018576622,
0.07164741307497025,
0.31033462285995483,
-0.01648244820535183,
-0.04960561916232109,
-0.07515849173069,
0.06670363247394562,
-0.07775527983903885,
-0.0015395994996652007,
-0.3005748689174652,
0.07569620758295059,
-0.26543840765953064,
0.1103367954492569,
-0.14930114150047302,
0.1287318617105484,
-0.19953277707099915,
0.09562218189239502,
-0.04050799086689949,
-0.21705983579158783,
0.02415245957672596,
-0.20377634465694427,
-0.05246312916278839,
-0.0032118370290845633,
0.04461270570755005,
0.18373656272888184,
0.4631257951259613,
-0.14773820340633392,
0.2511889636516571,
-0.05327405780553818,
0.17869804799556732,
-0.22989076375961304,
0.07874281704425812,
0.13065995275974274,
0.09017732739448547,
0.1017618328332901,
-0.02031276561319828,
0.07501214742660522,
0.16713999211788177,
0.018123943358659744,
0.1447419673204422,
-0.16052891314029694,
-0.17423823475837708,
0.07010386139154434,
-0.09281430393457413,
0.016565343365073204,
0.0005248088273219764,
0.04920300468802452,
-0.01393711194396019,
0.25952574610710144,
-0.1737675666809082,
0.2232763022184372,
0.01365810725837946,
-0.21699097752571106,
-0.29001063108444214,
-0.08645717054605484,
0.030021781101822853,
0.10067147016525269,
-0.05430272966623306,
-0.012602347880601883,
0.2171056568622589,
-0.15456195175647736,
0.05991467833518982,
-0.14506202936172485,
0.155457004904747,
-0.02300059050321579,
0.05408565327525139,
0.1047062799334526,
0.42255711555480957,
-0.10776069760322571,
-0.3069476783275604,
-0.19950006902217865,
-0.10429297387599945,
-0.01253359392285347,
0.010667773894965649,
0.16380955278873444,
-0.16301822662353516,
-0.16946275532245636,
0.2853832542896271,
-0.11866526305675507,
0.06104592606425285,
-0.13127604126930237,
-0.1786157339811325,
-0.17477190494537354,
-0.03933294117450714,
0.19196714460849762,
-0.2754085659980774,
0.030997978523373604,
-0.09285339713096619,
0.24894402921199799,
-0.06470706313848495,
-0.16128437221050262,
0.06056087464094162,
0.036956559866666794,
0.03146606683731079,
-0.133853018283844,
0.05536793917417526,
0.09867797046899796,
-0.21518246829509735,
0.09163246303796768,
0.05903419107198715,
-0.011292863637208939,
-0.10826040059328079,
-0.10140935331583023,
-0.37019073963165283,
-0.1292283982038498,
-0.17420904338359833,
-0.002182422438636422,
0.11253955215215683,
-0.14237132668495178,
-0.0708651915192604,
-0.12199851870536804,
-0.09419384598731995,
0.15723025798797607,
0.04074772074818611,
-0.1260709911584854,
-0.016011113300919533,
0.24780069291591644,
0.026388095691800117,
-0.06949411332607269,
-0.11287518590688705,
-0.10098950564861298,
0.22472600638866425,
0.19829732179641724,
0.031661201268434525,
0.06270971149206161,
-0.052506204694509506,
-0.06928683817386627,
-0.1898520588874817,
-0.1545805186033249,
0.11941061168909073,
-0.07091319561004639,
-0.11281617730855942,
-0.05883130058646202,
-0.07277674227952957,
0.028042905032634735,
-0.17788992822170258,
0.26296302676200867,
0.18355150520801544,
0.10389106720685959
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. diagnosis of PA is established using the following strategies.Figure 2. Immediate management and testing algorithm to be pursued simultaneously after the clinical or laboratory suspicion of PA I. Identification of biallelic pathogenic variants in PCCA or PCCB on molecular genetic testing (see Table 1). Molecular testing approaches can include serial single-gene testing, use of a multigene panel, and more comprehensive
genomic testing:Serial single-gene testing can be considered if (1) mutation of a particular gene accounts for a large proportion of the condition or (2) factors such as clinical findings, laboratory findings, and ancestry indicate that mutation of a particular gene is most likely.For PA, neither gene is more common and there are no characteristic findings to distinguish between PCCA- and PCCB-associated PA.In instances where this testing approach is the only one available, sequence analysis of either PCCA or PCCB is performed first, followed by gene-targeted deletion/duplication analysis if only one | [
-0.08206548541784286,
0.14751257002353668,
-0.026465194299817085,
-0.2322647124528885,
0.09207160025835037,
-0.06999733299016953,
0.1783023178577423,
-0.2523427903652191,
-0.0014650908997282386,
-0.035497114062309265,
0.1470232903957367,
0.027317196130752563,
0.016537360846996307,
0.06343697756528854,
-0.26030635833740234,
0.18517331779003143,
0.14675851166248322,
-0.06834127753973007,
0.022137194871902466,
-0.03719320148229599,
0.028611615300178528,
-0.16175010800361633,
0.07404235005378723,
0.0094924196600914,
0.243658646941185,
-0.14852559566497803,
0.2235288769006729,
-0.2863887846469879,
0.14381013810634613,
0.08052786439657211,
0.07808364182710648,
-0.04385862872004509,
0.027099261060357094,
-0.2231767326593399,
-0.04824034124612808,
-0.29077062010765076,
-0.018279235810041428,
-0.12728838622570038,
0.09535826742649078,
-0.2640286386013031,
-0.010889123193919659,
-0.04295753315091133,
0.32666611671447754,
-0.0634426698088646,
0.2197655588388443,
0.060760024935007095,
0.08676118403673172,
-0.028668619692325592,
0.04062271490693092,
0.14889322221279144,
0.19553306698799133,
-0.06594928354024887,
-0.2574063241481781,
-0.22700326144695282,
0.24983978271484375,
-0.04466448351740837,
-0.20815590023994446,
-0.04163997620344162,
-0.32549118995666504,
-0.053871966898441315,
0.09613321721553802,
-0.035460468381643295,
-0.23763145506381989,
-0.15987329185009003,
0.24797649681568146,
-0.09305454045534134,
0.006417021155357361,
0.04909198731184006,
0.08265812695026398,
-0.13667212426662445,
0.13697490096092224,
-0.13492794334888458,
0.10595840960741043,
-0.0045461347326636314,
-0.0709112212061882,
0.088894322514534,
-0.03939275071024895,
-0.013687693513929844,
0.036668017506599426,
-0.448396235704422,
-0.20984740555286407,
-0.13050851225852966,
0.02162325568497181,
-0.10264056921005249,
-0.11359336227178574,
-0.0016660657711327076,
0.1955152451992035,
-0.0025777334813028574,
0.033111803233623505,
0.1801643967628479,
0.17782659828662872,
-0.021032357588410378,
-0.0013127652928233147,
0.1044192761182785,
0.02353634126484394,
-0.12931381165981293,
0.11093005537986755,
0.014730150811374187,
-0.11102387309074402,
0.062482308596372604,
0.09082318097352982,
-0.07030414044857025,
-0.09681136906147003,
-0.13389424979686737,
0.09776823222637177,
0.11872886121273041,
-0.13776691257953644,
0.07104215025901794,
-0.1090819463133812,
0.0671364888548851,
0.11895553767681122,
-0.06768564879894257,
0.0904797688126564,
-0.04172155633568764,
-0.2508733570575714,
-0.0005230384995229542,
0.034035101532936096,
0.35935696959495544,
0.008184961974620819,
-0.06747187674045563,
0.024547286331653595,
0.09423013776540756,
-0.11054301261901855,
0.04633321613073349,
-0.08769799023866653,
0.020485782995820045,
0.06431610137224197,
-0.04407403618097305,
0.13322356343269348,
-0.08691711723804474,
0.07466007024049759,
0.2017396092414856,
-0.05844647437334061,
-0.004833971615880728,
0.044045303016901016,
-0.15963523089885712,
-0.2886579930782318,
-0.340830534696579,
0.030809905380010605,
0.0010762407910078764,
0.15854224562644958,
0.15422019362449646,
0.07868137955665588,
0.15441742539405823,
0.07972181588411331,
0.09602252393960953,
0.25150611996650696,
-0.12728402018547058,
-0.05527661368250847,
-0.006199516821652651,
0.02875632420182228,
-0.2050236463546753,
0.13675004243850708,
0.16490638256072998,
-0.10919436812400818,
0.05412435531616211,
0.03200281038880348,
0.3684832453727722,
-0.13655787706375122,
0.05725787207484245,
0.13722167909145355,
0.09527599811553955,
0.042662132531404495,
-0.091998390853405,
0.12800098955631256,
0.01368751935660839,
-0.08991139382123947,
0.10061164945363998,
-0.13512617349624634,
-0.033762235194444656,
-0.13325367867946625,
-0.022187747061252594,
0.046731170266866684,
0.17669223248958588,
0.1154085174202919,
0.17891532182693481,
-0.14436763525009155,
0.022037630900740623,
0.033463433384895325,
0.011006026528775692,
0.17058473825454712,
-0.03356330096721649,
-0.3423996865749359,
-0.0036801090463995934,
-0.09487365186214447,
0.016146235167980194,
0.276787132024765,
0.06393223255872726,
-0.012256029061973095,
0.24716703593730927,
0.11533311754465103,
-0.05836259573698044,
0.041559625416994095,
-0.08768904209136963,
0.17680524289608002,
-0.13555188477039337,
0.003981631714850664,
0.1471940279006958,
-0.23371796309947968,
-0.1729709357023239,
-0.1633007526397705,
-0.13301464915275574,
0.005808661691844463,
-0.034617312252521515,
-0.11408177763223648,
-0.08551716804504395,
0.12760262191295624,
-0.10957275331020355,
-0.029575111344456673,
-0.030157767236232758,
-0.08918215334415436,
0.1423959583044052,
-0.23189173638820648,
0.15144479274749756,
-0.07265661656856537,
-0.07556021213531494,
0.08518591523170471,
-0.12104789167642593,
0.12122079730033875,
0.289101243019104,
0.031356483697891235,
0.11750374734401703,
0.02865998074412346,
-0.1782696545124054,
-0.07241955399513245,
0.12796425819396973,
-0.16501320898532867,
-0.0021870890632271767,
0.045749519020318985,
-0.2617335021495819,
-0.03183496743440628,
-0.1240444928407669,
-0.02720833569765091,
0.12489321827888489,
-0.23786041140556335,
-0.09126519411802292,
-0.06885792315006256,
0.2397531419992447,
0.1699458658695221,
-0.030212972313165665,
-0.2860901951789856,
0.007976594381034374,
0.13584637641906738,
0.10784566402435303,
0.04527975246310234,
0.0458558164536953,
0.006247729994356632,
0.1375543624162674,
-0.1125529408454895,
0.16198407113552094,
0.06105303391814232,
0.13231228291988373,
-0.06978153437376022,
0.05229149013757706,
-0.4033716022968292,
-0.24813267588615417,
-0.0780414268374443,
-0.04806128144264221,
0.13680928945541382,
-0.07043725997209549,
-0.1343141794204712,
0.10094188898801804,
0.15838386118412018,
0.1263657510280609,
-0.010428092442452908,
-0.0003761310363188386,
-0.24393071234226227,
-0.046371541917324066,
-0.07666967809200287,
-0.10138265043497086,
-0.08569911867380142,
0.08366388082504272,
0.07927249372005463,
0.1713489443063736,
-0.20127688348293304,
0.04497102275490761,
-0.016869280487298965,
0.10308795422315598,
-0.011450356803834438,
0.07582055032253265,
-0.16929888725280762,
0.14196443557739258,
-0.06676563620567322,
0.1082523912191391,
0.17317786812782288,
-0.02476254478096962,
0.04421347752213478,
-0.016019798815250397,
-0.0751073807477951,
0.008490033447742462,
0.010318809188902378,
0.0692785233259201,
-0.1380481719970703,
-0.0006148571847006679,
0.04078621417284012,
0.22009576857089996,
0.017684409394860268,
0.0662139281630516,
-0.11185082793235779,
-0.03325395658612251,
0.13928456604480743,
0.012546773999929428,
0.08706524968147278,
-0.1365121304988861,
-0.28588801622390747,
0.05026597902178764,
0.01480815839022398,
0.041120078414678574,
0.12829966843128204,
0.32065001130104065,
-0.12546244263648987,
-0.2111351191997528,
-0.37505772709846497,
0.12586982548236847,
0.03542778268456459,
-0.0065354881808161736,
0.025390254333615303,
0.1306421011686325,
0.14264464378356934,
0.28964343667030334,
-0.012437425553798676,
0.07683426886796951,
0.1541673094034195,
0.09568990767002106,
-0.29631882905960083,
-0.05528144910931587,
-0.12513791024684906,
0.03985422104597092,
-0.09072045236825943,
0.06842520833015442,
0.0661512091755867,
0.1055038645863533,
0.014111821539700031,
-0.031840357929468155,
0.1894243210554123,
0.0019720327109098434,
0.30093708634376526,
-0.007191801443696022,
-0.07027558982372284,
0.226351797580719,
0.12617719173431396,
-0.3987732529640198,
-0.05256439745426178,
0.02640981785953045,
-0.07635145634412766,
0.034700192511081696,
-0.015545527450740337,
-0.015563796274363995,
0.0763050764799118,
-0.2178240567445755,
-0.036411311477422714,
-0.04894047975540161,
-0.07982054352760315,
-0.24618129432201385,
0.35794851183891296,
0.024946492165327072,
0.023187881335616112,
0.12104716151952744,
0.04064727947115898,
0.14259681105613708,
-0.21387691795825958,
0.004914077930152416,
0.2022261917591095,
-0.08556398749351501,
0.1615922451019287,
-0.1097555086016655,
0.006447863765060902,
0.15009957551956177,
0.28336217999458313,
0.08328241854906082,
0.07941609621047974,
0.07710083574056625,
0.06307299435138702,
0.2148008495569229,
0.05765555799007416,
0.16039630770683289,
0.05417843535542488,
0.14276105165481567,
-0.24230699241161346,
-0.2432991862297058,
0.045418281108140945,
-0.09498602896928787,
-0.020073454827070236,
-0.0731566920876503,
0.04508868604898453,
0.10449390858411789,
-0.06130465865135193,
0.12222803384065628,
0.19252252578735352,
-0.36515486240386963,
0.018903320655226707,
-0.0003561149933375418,
0.05632387101650238,
0.11213710159063339,
0.03500282019376755,
0.18688897788524628,
0.05714807286858559,
-0.05975477024912834,
-0.04113560542464256,
0.12313221395015717,
-0.10492025315761566,
-0.14560334384441376,
0.17581981420516968,
0.25876325368881226,
-0.018154826015233994,
-0.11701653897762299,
0.038260720670223236,
0.09655172377824783,
0.05600146949291229,
0.10015982389450073,
-0.02248646691441536,
0.09392566233873367,
0.06767437607049942,
-0.09866540879011154,
-0.042954444885253906,
-0.11242639273405075,
-0.19402506947517395,
0.00012614013394340873,
-0.027173928916454315,
-0.007647919002920389,
-0.06249479576945305,
0.1434660255908966,
0.1123119443655014,
-0.06892033666372299,
-0.11427883803844452,
0.03277871012687683,
-0.02840220183134079,
-0.10529019683599472,
0.08598002046346664,
0.0030456804670393467,
0.10629285871982574,
0.05202042683959007,
-0.22862215340137482,
-0.025443729013204575,
0.022747861221432686,
0.060575295239686966,
0.1084204614162445,
0.030429353937506676,
0.035375360399484634,
-0.02475510910153389,
0.09589053690433502,
-0.0022130063734948635,
-0.09180814772844315,
0.11234116554260254,
-0.06904876977205276,
0.12617601454257965,
0.2564341723918915,
0.1744016706943512,
-0.002646624343469739,
0.05399172380566597,
0.03483522683382034,
-0.11168858408927917,
-0.2094155251979828,
-0.028158513829112053,
0.08946482837200165,
0.12322873622179031,
-0.018788496032357216,
-0.288681298494339,
0.01741687022149563,
-0.17721182107925415,
-0.15969538688659668,
0.1540111005306244,
0.24518658220767975,
0.049543239176273346,
-0.04839126393198967,
-0.00093615404330194,
-0.06804706901311874,
-0.015970176085829735,
0.255872905254364,
0.025553207844495773,
0.21214692294597626,
0.05915931984782219,
-0.07427871227264404,
0.12465760111808777,
-0.15987233817577362,
0.08237013965845108,
0.06579142808914185,
-0.047819528728723526,
-0.0020456891506910324,
0.12858188152313232,
-0.06531739979982376,
-0.32235702872276306,
-0.06171628087759018,
-0.027318190783262253,
-0.10958689451217651,
0.2456476092338562,
-0.12271714955568314,
-0.0862802192568779,
0.012997160665690899,
-0.16862852871418,
-0.05481000244617462,
0.10926957428455353,
0.028320427983999252,
0.2427332103252411,
-0.09741418808698654,
-0.35221168398857117,
-0.13552318513393402,
-0.18716950714588165,
-0.10106197744607925,
0.057647619396448135,
-0.16673289239406586,
0.1324269324541092,
-0.039889127016067505,
0.18467681109905243,
-0.15158286690711975,
-0.16245697438716888,
-0.0577397458255291,
-0.17200197279453278,
0.038231074810028076,
0.22781570255756378,
-0.2494804412126541,
0.06666053086519241,
-0.04433293268084526,
0.057387374341487885,
-0.04997098818421364,
-0.29071635007858276,
-0.04711258411407471,
0.1651061326265335,
-0.013627341948449612,
-0.021513398736715317,
0.10319908708333969,
-0.041428495198488235,
0.20133651793003082,
-0.028029927983880043,
0.039180297404527664,
-0.0731431096792221,
0.001727201510220766,
0.2121012657880783,
0.075612373650074,
-0.21341019868850708,
-0.03852081671357155,
-0.08588266372680664,
-0.119967982172966,
0.016868459060788155,
0.1350662112236023,
0.13404043018817902,
0.06429744511842728,
-0.15715403854846954,
-0.32112523913383484,
-0.12412941455841064,
-0.1475028395652771,
-0.06506558507680893,
0.11647417396306992,
-0.05493677034974098,
-0.14226825535297394,
0.04340231791138649,
0.09812682121992111,
0.18477626144886017,
0.15153251588344574,
0.03463105112314224,
-0.06583051383495331,
-0.1571328192949295,
0.0448358915746212,
0.016048327088356018,
-0.036580078303813934,
-0.18261197209358215,
0.04430413618683815,
-0.03165212646126747,
-0.17304377257823944,
-0.02199392206966877,
-0.06391588598489761,
-0.0245579294860363,
-0.20841602981090546,
-0.10271523147821426,
0.024175576865673065,
0.2051578313112259,
0.08249175548553467,
-0.18080630898475647,
0.14765745401382446,
0.004799417220056057,
-0.0362548753619194,
0.12255801260471344,
0.1563691943883896,
-0.002725381636992097,
-0.1949402242898941,
0.15936169028282166,
-0.17041319608688354,
-0.38373255729675293,
-0.11483331024646759,
0.09092570841312408,
0.05711827799677849,
-0.24643801152706146,
0.04571161046624184,
-0.15450912714004517,
0.16387605667114258,
0.11408905684947968,
-0.025900430977344513,
0.05839532986283302,
0.13729259371757507,
-0.1274612993001938,
-0.12130582332611084,
-0.11428812146186829,
0.09987791627645493,
0.03282558172941208,
0.11098980158567429,
-0.25937604904174805,
0.2732405364513397,
-0.04841763526201248,
-0.08350921422243118,
-0.06753062456846237,
-0.07461550831794739,
0.21602670848369598,
-0.13303028047084808,
-0.08926087617874146,
0.0544278621673584,
-0.07163531333208084,
0.0870927944779396,
-0.22661727666854858,
-0.007393043953925371,
-0.040476392954587936,
0.0014336140593513846,
-0.023098669946193695,
0.13216882944107056,
-0.04183301329612732,
0.05010046809911728,
0.03525407612323761,
0.2985260486602783,
0.01689598150551319,
0.2533430755138397,
-0.17267698049545288,
0.3168383836746216,
-0.01352047361433506,
0.024710552766919136,
-0.1741122156381607,
-0.11673159152269363,
0.1302306056022644,
-0.10416293144226074,
-0.013733118772506714,
0.09305310994386673,
-0.2055806666612625,
0.017389288172125816,
0.28227317333221436,
0.08933072537183762,
-0.0007772359531372786,
-0.11472409218549728,
0.13778729736804962,
-0.10452770441770554,
-0.09541504085063934,
-0.18785379827022552,
0.008610597811639309,
-0.17129220068454742,
0.16135068237781525,
-0.112051822245121,
0.13256266713142395,
-0.1992475539445877,
0.021247373893857002,
-0.06216268986463547,
-0.2212524265050888,
0.03850740194320679,
-0.012964265421032906,
-0.04362131655216217,
0.11757688224315643,
-0.09899692982435226,
0.25878003239631653,
0.32296350598335266,
-0.0893482193350792,
0.24276545643806458,
-0.005888013634830713,
0.24112270772457123,
-0.2074682116508484,
-0.019200926646590233,
-0.02013852261006832,
0.007624534424394369,
0.09820906817913055,
0.0750681534409523,
0.048964232206344604,
0.1315993070602417,
0.06330467015504837,
0.10870814323425293,
-0.23133784532546997,
-0.18399621546268463,
-0.0007671624189242721,
-0.016634367406368256,
0.024465208873152733,
0.1048324704170227,
0.1382039189338684,
-0.054864637553691864,
0.2546425759792328,
-0.18570488691329956,
0.17226488888263702,
0.03314518928527832,
-0.31185221672058105,
-0.22549346089363098,
-0.05095712095499039,
-0.056848347187042236,
0.057046592235565186,
-0.050478313118219376,
0.011179458349943161,
0.12608908116817474,
-0.05198223143815994,
0.03856566175818443,
-0.04295117035508156,
0.044195134192705154,
0.19533371925354004,
0.06136932969093323,
0.11188659816980362,
0.27069687843322754,
-0.11098883301019669,
-0.3625892400741577,
-0.18636134266853333,
-0.04334690049290657,
-0.08654435724020004,
-0.0022297492250800133,
0.20650070905685425,
-0.21033406257629395,
-0.11624495685100555,
0.2151736617088318,
-0.1099284216761589,
0.06454525142908096,
-0.1031118854880333,
-0.20159627497196198,
-0.058136727660894394,
-0.018194960430264473,
0.09141843020915985,
-0.2073500007390976,
0.11242371797561646,
-0.11130614578723907,
0.2512032687664032,
-0.0421319417655468,
-0.23587346076965332,
0.11133682727813721,
0.01142184529453516,
-0.03695182129740715,
-0.16797488927841187,
0.12610357999801636,
0.05738550052046776,
-0.2624860405921936,
0.18048466742038727,
0.20869646966457367,
-0.11014729738235474,
-0.08964747190475464,
-0.10788378864526749,
-0.4047413468360901,
-0.1404293030500412,
-0.11488983780145645,
0.09708498418331146,
0.024394381791353226,
0.01774628460407257,
-0.025498976930975914,
-0.2903382480144501,
-0.04057830944657326,
0.08926370739936829,
0.041412901133298874,
-0.25981011986732483,
0.06992807239294052,
0.15188051760196686,
0.0018241797806695104,
-0.18607529997825623,
-0.08311741054058075,
-0.029152221977710724,
0.13043850660324097,
0.10028640180826187,
-0.020757237449288368,
-0.03464564308524132,
-0.10454533249139786,
-0.07534154504537582,
-0.144500270485878,
-0.20904791355133057,
0.22607924044132233,
-0.09081091731786728,
-0.08374518901109695,
-0.10953328758478165,
-0.007828009314835072,
0.06645087897777557,
-0.15080422163009644,
0.17757105827331543,
-0.0071110506542027,
0.10012310743331909
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. particular gene accounts for a large proportion of the condition or (2) factors such as clinical findings, laboratory findings, and ancestry indicate that mutation of a particular gene is most likely.For PA, neither gene is more common and there are no characteristic findings to distinguish between PCCA- and PCCB-associated PA.In instances where this testing approach is the only one available, sequence analysis of either PCCA or PCCB is performed first, followed by gene-targeted deletion/duplication analysis if only one or no pathogenic variant is found.A multigene panel that includes PCCA and PCCB and other genes of interest (see Differential Diagnosis) may also be considered. Note: (1) The genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this GeneReview; thus, clinicians need to | [
0.029505085200071335,
0.20056651532649994,
-0.023567749187350273,
-0.22755658626556396,
0.17162266373634338,
-0.05791086703538895,
0.14601434767246246,
-0.2735096514225006,
0.019358821213245392,
-0.011600814759731293,
0.16959449648857117,
0.00011450012971181422,
0.07382988929748535,
0.07282903045415878,
-0.24514944851398468,
0.17160645127296448,
0.1527353972196579,
-0.16348880529403687,
-0.04772820323705673,
0.0072698406875133514,
0.10010096430778503,
-0.12568217515945435,
0.16608363389968872,
-0.00300287245772779,
0.30011868476867676,
-0.17872993648052216,
0.2309291511774063,
-0.2427021861076355,
0.17860688269138336,
0.08883600682020187,
0.0762157216668129,
-0.08571910858154297,
0.04803699627518654,
-0.19644513726234436,
-0.0583740696310997,
-0.33551451563835144,
-0.03348087891936302,
-0.15189722180366516,
0.129416361451149,
-0.2027347981929779,
-0.009087834507226944,
-0.025750592350959778,
0.288776159286499,
-0.005120181944221258,
0.22714141011238098,
-0.027727825567126274,
0.07866965979337692,
0.0022416666615754366,
0.041042715311050415,
0.07559005171060562,
0.12643352150917053,
-0.05613157898187637,
-0.22196082770824432,
-0.14236034452915192,
0.2171332836151123,
-0.011759878136217594,
-0.19020415842533112,
-0.047198519110679626,
-0.30855587124824524,
-0.023563098162412643,
0.11159893870353699,
-0.00024096145352814347,
-0.19805008172988892,
-0.15635643899440765,
0.2402310073375702,
-0.0681144967675209,
0.0032110095489770174,
0.035411350429058075,
0.07963190972805023,
-0.12481047213077545,
0.10368011146783829,
-0.11732061207294464,
0.02107684127986431,
-0.05695689097046852,
-0.08879876136779785,
0.049719393253326416,
-0.014368068426847458,
0.02065546065568924,
0.07829930633306503,
-0.4183023273944855,
-0.1625385582447052,
-0.12023570388555527,
0.03799142688512802,
-0.11823395639657974,
-0.04962102323770523,
-0.08201885223388672,
0.2355835884809494,
-0.004982484504580498,
-0.054169099777936935,
0.13995413482189178,
0.12001899629831314,
0.00045044173020869493,
0.06408717483282089,
0.1873377561569214,
0.049558933824300766,
-0.12713833153247833,
0.13807186484336853,
-0.007758065592497587,
-0.0461215116083622,
0.05443855747580528,
0.10571642220020294,
-0.04894411191344261,
-0.12394843250513077,
-0.13944976031780243,
0.13942547142505646,
0.12902097404003143,
-0.08237683773040771,
0.10552091896533966,
-0.04960222914814949,
0.016581416130065918,
0.1137281283736229,
-0.031445614993572235,
0.06035614386200905,
0.06739697605371475,
-0.2571873366832733,
-0.008221004158258438,
-0.001482890103943646,
0.3303070366382599,
0.00007161094254115596,
-0.057622190564870834,
0.083035908639431,
0.041225433349609375,
-0.13624031841754913,
0.11540882289409637,
-0.04777805507183075,
-0.04870104789733887,
0.16340136528015137,
-0.061575260013341904,
0.12034633010625839,
-0.08537068963050842,
0.05310484394431114,
0.1940692663192749,
-0.08863116055727005,
-0.04205968230962753,
0.05007261782884598,
-0.11323259025812149,
-0.3340679109096527,
-0.3359683156013489,
0.060521580278873444,
-0.012038174085319042,
0.20375676453113556,
0.05861910805106163,
0.07859673351049423,
0.05780171602964401,
0.09566695988178253,
0.10701405256986618,
0.2250712662935257,
-0.12614823877811432,
-0.0657511055469513,
0.006746713072061539,
-0.017852216958999634,
-0.1472553163766861,
0.11510118097066879,
0.17161588370800018,
-0.15304210782051086,
0.01755300909280777,
0.01584426499903202,
0.29038316011428833,
-0.11798844486474991,
0.053296465426683426,
0.1409035176038742,
0.14474858343601227,
0.12105324864387512,
-0.029013492166996002,
0.1662319302558899,
0.0874612033367157,
-0.0012022340670228004,
0.13852274417877197,
-0.06985282897949219,
-0.0077827624045312405,
-0.11880633980035782,
0.03894181177020073,
0.06747348606586456,
0.12122436612844467,
0.022293424233794212,
0.1535331904888153,
-0.18392640352249146,
0.027402466163039207,
-0.02772110141813755,
-0.008223652839660645,
0.19389361143112183,
0.011607693508267403,
-0.29430684447288513,
-0.05697805806994438,
-0.08846057951450348,
0.012830869294703007,
0.22973191738128662,
0.06722594052553177,
0.0001626468583708629,
0.23517464101314545,
0.1226949617266655,
-0.09003997594118118,
-0.0027621767949312925,
-0.08378000557422638,
0.19252720475196838,
-0.13624568283557892,
0.009458011016249657,
0.18652129173278809,
-0.18941578269004822,
-0.13006314635276794,
-0.13547417521476746,
-0.16205888986587524,
-0.03198528662323952,
-0.04457617923617363,
-0.13259081542491913,
-0.03046530857682228,
0.09453315287828445,
-0.014398225583136082,
0.02621740661561489,
0.03389938175678253,
-0.11600285023450851,
0.0974724292755127,
-0.20407843589782715,
0.18674035370349884,
-0.015466579236090183,
-0.029637835919857025,
0.08265558630228043,
-0.08786110579967499,
0.14409424364566803,
0.3543514609336853,
0.03263654559850693,
0.17289002239704132,
-0.04092709347605705,
-0.15386523306369781,
-0.0835837796330452,
0.08648434281349182,
-0.15028533339500427,
-0.03493403270840645,
0.024563169106841087,
-0.16779682040214539,
-0.07488108426332474,
-0.13186246156692505,
-0.06496620178222656,
0.08756796270608902,
-0.19895285367965698,
-0.04334036260843277,
-0.04872455075383186,
0.20084212720394135,
0.12950043380260468,
-0.007676529698073864,
-0.21340709924697876,
0.014127111062407494,
0.14718179404735565,
0.08043377101421356,
0.01990400440990925,
0.023199714720249176,
0.028256690129637718,
0.10693204402923584,
-0.10781950503587723,
0.10731223225593567,
0.011884371750056744,
0.1589866280555725,
-0.08700535446405411,
0.07453306019306183,
-0.4066403806209564,
-0.2014586180448532,
-0.09939978271722794,
-0.05928266793489456,
0.0957128256559372,
-0.04291412606835365,
-0.17289669811725616,
0.0647219642996788,
0.1233057901263237,
0.13986077904701233,
-0.1672990322113037,
0.0018187891691923141,
-0.2586127817630768,
-0.009848115965723991,
-0.025293244048953056,
-0.12573261559009552,
-0.11651510000228882,
0.1470702737569809,
0.024840714409947395,
0.21921594440937042,
-0.17129819095134735,
-0.033290836960077286,
0.07822833955287933,
0.04519283026456833,
0.07466600090265274,
-0.008390934206545353,
-0.13677774369716644,
0.11358297616243362,
-0.01187148131430149,
0.13210582733154297,
0.21158573031425476,
-0.06462694704532623,
0.07946859300136566,
-0.022899815812706947,
-0.03693092614412308,
0.05083552002906799,
0.03694123029708862,
0.10237918049097061,
-0.09056214988231659,
-0.0007275552488863468,
0.02991195023059845,
0.14337190985679626,
0.03324277698993683,
0.03464131057262421,
-0.10179122537374496,
-0.02488821931183338,
0.14153830707073212,
0.033192798495292664,
0.010892864316701889,
-0.14776109158992767,
-0.2169753462076187,
0.09194732457399368,
0.014705519191920757,
0.00231448607519269,
0.056276947259902954,
0.264197438955307,
-0.13873586058616638,
-0.17915819585323334,
-0.3694990277290344,
0.16586080193519592,
0.07213542610406876,
0.035926640033721924,
0.039709847420454025,
0.09109409153461456,
0.17827516794204712,
0.29250967502593994,
0.027666490525007248,
0.06010232865810394,
0.17479835450649261,
0.015289154835045338,
-0.2438109964132309,
0.007407617289572954,
-0.13221043348312378,
0.017665861174464226,
-0.08941610157489777,
0.08280821889638901,
0.046448759734630585,
0.08474256843328476,
-0.05348031967878342,
-0.016970399767160416,
0.1374756395816803,
0.13422106206417084,
0.2887438237667084,
-0.05661546438932419,
-0.08544285595417023,
0.17559069395065308,
0.08197211474180222,
-0.40853649377822876,
-0.10717310011386871,
0.05352136865258217,
-0.054642453789711,
0.04054693505167961,
-0.025701211765408516,
-0.05690787360072136,
0.026213793084025383,
-0.20269519090652466,
-0.020021233707666397,
-0.08560889214277267,
-0.047348327934741974,
-0.25135162472724915,
0.3362806439399719,
0.08309386670589447,
0.057582635432481766,
0.10022023320198059,
-0.0420212559401989,
0.17547155916690826,
-0.18258945643901825,
0.00767054408788681,
0.17249925434589386,
-0.0787634626030922,
0.11101974546909332,
-0.21261173486709595,
-0.017033802345395088,
0.15908417105674744,
0.19235996901988983,
0.1652207225561142,
0.03965843468904495,
0.1509709507226944,
0.028403766453266144,
0.15954986214637756,
0.03860342502593994,
0.18800705671310425,
0.03271275386214256,
0.11002033948898315,
-0.2516461908817291,
-0.19942913949489594,
0.054518088698387146,
-0.056788165122270584,
0.04642472416162491,
-0.11652184277772903,
0.09851530939340591,
0.053845182061195374,
-0.13994787633419037,
0.09705323725938797,
0.18817418813705444,
-0.28044822812080383,
-0.10245489329099655,
0.01597081497311592,
0.08284420520067215,
0.09094928950071335,
0.05935944616794586,
0.19719552993774414,
0.03558274358510971,
-0.013782412745058537,
-0.10696279257535934,
0.12137773633003235,
-0.08210340142250061,
-0.11556661874055862,
0.1181916743516922,
0.2525210380554199,
0.007410172373056412,
-0.028612632304430008,
0.019897809252142906,
0.07887649536132812,
0.08041967451572418,
0.08722462505102158,
0.015380696393549442,
0.12144073098897934,
0.023998288437724113,
-0.09353038668632507,
-0.11666607856750488,
-0.15175358951091766,
-0.10115832835435867,
-0.006128027569502592,
-0.08239997923374176,
-0.007075165864080191,
-0.07163753360509872,
0.16057650744915009,
0.062261369079351425,
-0.07272247225046158,
-0.1119404137134552,
0.01085940282791853,
-0.02525988221168518,
-0.03982721269130707,
0.08715012669563293,
0.0009243750828318298,
0.15361420810222626,
0.18845824897289276,
-0.2123120278120041,
-0.06514371931552887,
-0.011172672733664513,
0.05542164295911789,
0.11650144308805466,
-0.024222640320658684,
0.11141309142112732,
-0.005261093378067017,
0.11726734042167664,
0.06438268721103668,
-0.10775575786828995,
0.12215226143598557,
-0.1167675331234932,
0.19650425016880035,
0.2093866616487503,
0.16356340050697327,
0.09126690775156021,
0.0458989180624485,
-0.0014215174596756697,
-0.1273878514766693,
-0.20482249557971954,
-0.06346461921930313,
0.12087990343570709,
0.09250085055828094,
0.043866369873285294,
-0.25871801376342773,
0.043195318430662155,
-0.2091163694858551,
-0.14617811143398285,
0.12734851241111755,
0.28001412749290466,
0.04764233157038689,
-0.00837742444127798,
-0.04818425700068474,
0.005023367237299681,
-0.01387216616421938,
0.2605443298816681,
0.06681796908378601,
0.2482021450996399,
0.04599670693278313,
-0.017641572281718254,
0.06165873631834984,
-0.12443932145833969,
0.0941009595990181,
0.06934851408004761,
-0.012536806985735893,
-0.04306749254465103,
0.10528989881277084,
-0.09359882771968842,
-0.28398582339286804,
-0.12648867070674896,
-0.04281552508473396,
-0.11522023379802704,
0.24842481315135956,
-0.10826265066862106,
-0.03240245208144188,
0.0028175227344036102,
-0.16946810483932495,
-0.0540638230741024,
0.13737107813358307,
0.07697536796331406,
0.23984378576278687,
-0.11059436947107315,
-0.33262479305267334,
-0.11977063864469528,
-0.1814648061990738,
-0.09037460386753082,
-0.0376548133790493,
-0.11507928371429443,
0.1244444027543068,
-0.037882301956415176,
0.19206157326698303,
-0.16174426674842834,
-0.1952527016401291,
-0.008932399563491344,
-0.17102432250976562,
0.08807194232940674,
0.20561465620994568,
-0.2334030419588089,
0.057617075741291046,
-0.033194709569215775,
-0.006901686545461416,
-0.06053789705038071,
-0.2442009449005127,
-0.012738424353301525,
0.10352817177772522,
0.0028200780507177114,
0.015327515080571175,
0.22083909809589386,
-0.04495296999812126,
0.19592460989952087,
-0.07542756199836731,
0.06365527957677841,
-0.21768127381801605,
-0.009430009871721268,
0.24122899770736694,
0.05252259597182274,
-0.22885887324810028,
0.004219419322907925,
-0.030664999037981033,
-0.05172630399465561,
0.011503826826810837,
0.05915062129497528,
0.14211063086986542,
0.04521070048213005,
-0.15415433049201965,
-0.29387959837913513,
-0.211393803358078,
-0.08071890473365784,
-0.09541931003332138,
0.12540817260742188,
-0.07261241227388382,
-0.13735026121139526,
0.02271488681435585,
0.10067851841449738,
0.23807190358638763,
0.2042112946510315,
0.034257348626852036,
-0.08409585058689117,
-0.1407269835472107,
0.0812559574842453,
0.04436498507857323,
-0.04510702192783356,
-0.11717819422483444,
0.056313809007406235,
-0.014007307589054108,
-0.11559923738241196,
0.016260741278529167,
-0.09997814893722534,
0.06109706684947014,
-0.1793295443058014,
-0.05612895265221596,
-0.011312157846987247,
0.2015015035867691,
0.05090397968888283,
-0.18926537036895752,
0.1944199502468109,
0.097498320043087,
-0.04951784759759903,
0.019037282094359398,
0.20524385571479797,
0.010033590719103813,
-0.14121104776859283,
0.12377431988716125,
-0.1764090210199356,
-0.2865103483200073,
-0.11323343217372894,
0.10240807384252548,
-0.04530411586165428,
-0.20072434842586517,
0.10409500449895859,
-0.13681046664714813,
0.126675546169281,
0.13717509806156158,
-0.03601827472448349,
0.029992828145623207,
0.10044978559017181,
-0.09576908499002457,
-0.1022653579711914,
-0.047221314162015915,
0.11383001506328583,
0.060852665454149246,
0.041197825223207474,
-0.2215462327003479,
0.24945583939552307,
-0.03784765303134918,
-0.0707387626171112,
-0.09954650700092316,
-0.014540322124958038,
0.16954751312732697,
-0.11293786019086838,
-0.0822434201836586,
0.018838930875062943,
-0.08801823109388351,
0.08325501531362534,
-0.28039833903312683,
-0.0007628967287018895,
-0.07375023514032364,
-0.03841021656990051,
0.0002811187005136162,
0.1046675592660904,
-0.030058352276682854,
0.08608800172805786,
0.050325702875852585,
0.30859580636024475,
0.006107734050601721,
0.24419158697128296,
-0.13242626190185547,
0.31880322098731995,
-0.03580132871866226,
0.050200775265693665,
-0.24345190823078156,
-0.10812314599752426,
0.14337854087352753,
-0.16997836530208588,
0.04509986564517021,
0.06823551654815674,
-0.20561392605304718,
0.11266922205686569,
0.25081777572631836,
0.024464698508381844,
0.030980169773101807,
-0.07988686114549637,
0.14278164505958557,
-0.05734555050730705,
-0.10385740548372269,
-0.14797991514205933,
0.03180045634508133,
-0.13679756224155426,
0.171431764960289,
-0.09617006778717041,
0.059509072452783585,
-0.20978286862373352,
0.049753930419683456,
-0.15132586658000946,
-0.18511098623275757,
-0.02833576872944832,
0.021025322377681732,
-0.055962979793548584,
0.156164288520813,
-0.1320846676826477,
0.2190985381603241,
0.2791716754436493,
-0.11241333186626434,
0.1771881878376007,
0.032018326222896576,
0.27265259623527527,
-0.16443563997745514,
-0.05652298778295517,
-0.0547330416738987,
-0.01892824098467827,
0.07138165086507797,
0.07490213215351105,
0.05461151525378227,
0.17007000744342804,
0.08120326697826385,
0.13809530436992645,
-0.2847526967525482,
-0.2574760317802429,
0.004192666616290808,
0.0229969322681427,
0.0006128280074335635,
0.11582115292549133,
0.1186196580529213,
-0.05341479182243347,
0.19380104541778564,
-0.11984317749738693,
0.24196942150592804,
0.036692630499601364,
-0.2834700345993042,
-0.20035168528556824,
-0.04735620692372322,
-0.09415249526500702,
0.037681616842746735,
-0.014194359071552753,
0.028516899794340134,
0.10764975845813751,
-0.11096607893705368,
0.018337301909923553,
-0.06237463653087616,
-0.004174499306827784,
0.14441896975040436,
0.02543777972459793,
0.027019882574677467,
0.2842969000339508,
-0.13304780423641205,
-0.31928667426109314,
-0.1385946422815323,
-0.10537925362586975,
-0.08249162882566452,
0.06996539980173111,
0.21256189048290253,
-0.17421087622642517,
-0.12863872945308685,
0.22325226664543152,
-0.08567783236503601,
0.06348417699337006,
-0.09779300540685654,
-0.17652752995491028,
-0.10877923667430878,
0.011091620661318302,
0.0074782040901482105,
-0.19454188644886017,
0.11941448599100113,
-0.05966069549322128,
0.19046904146671295,
0.006429133005440235,
-0.2292686104774475,
0.09842243045568466,
-0.019174670800566673,
-0.03658045083284378,
-0.17012225091457367,
0.1395910233259201,
0.028449008241295815,
-0.22644808888435364,
0.22831572592258453,
0.2022131234407425,
-0.08167360723018646,
-0.08342207223176956,
-0.03588229417800903,
-0.35570207238197327,
-0.08493778109550476,
-0.07979866117238998,
0.08625282347202301,
0.02615860104560852,
0.05941825360059738,
-0.03212708607316017,
-0.2570592164993286,
0.05854320153594017,
0.07835230976343155,
0.00983871053904295,
-0.24629652500152588,
0.089150570333004,
0.10243912041187286,
0.005868702661246061,
-0.22089765965938568,
-0.0687967836856842,
-0.043087657541036606,
0.13796056807041168,
0.1967521607875824,
-0.00923164002597332,
-0.09072866290807724,
-0.06174401566386223,
-0.09257647395133972,
-0.06532464921474457,
-0.19864678382873535,
0.14336106181144714,
-0.13409270346164703,
-0.07493291795253754,
-0.13183166086673737,
0.02297217585146427,
0.013890829868614674,
-0.11842448264360428,
0.21113184094429016,
-0.06946993619203568,
0.021627383306622505
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. /duplication analysis if only one or no pathogenic variant is found.A multigene panel that includes PCCA and PCCB and other genes of interest (see Differential Diagnosis) may also be considered. Note: (1) The genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this GeneReview; thus, clinicians need to determine which multigene panel is most likely to identify the genetic cause of the condition at the most reasonable cost while limiting identification of variants of uncertain significance and pathogenic variants in genes that do not explain the underlying phenotype. (3) In some laboratories, panel options may include a custom laboratory-designed panel and/or custom phenotype-focused exome analysis that includes genes specified by the clinician. (4) Methods used in a panel may include sequence analysis, deletion/duplication analysis, | [
0.040003400295972824,
0.15620288252830505,
-0.022987958043813705,
-0.26912757754325867,
0.015932470560073853,
-0.06662557274103165,
0.17902971804141998,
-0.15029045939445496,
0.013116645626723766,
0.09146296232938766,
0.1933361142873764,
-0.0007230860646814108,
0.009038997814059258,
0.06572499871253967,
-0.31930625438690186,
0.17247676849365234,
0.10492955148220062,
-0.1089787557721138,
-0.037593502551317215,
0.11984378844499588,
0.0643063485622406,
-0.15678249299526215,
0.1010318323969841,
0.05683765187859535,
0.16625982522964478,
-0.16522714495658875,
0.20476534962654114,
-0.1670798510313034,
0.2194162905216217,
0.004293678794056177,
0.005549125373363495,
-0.047877952456474304,
-0.05372894927859306,
-0.1944829672574997,
-0.12649764120578766,
-0.29536551237106323,
0.0004797923320438713,
-0.16621097922325134,
0.1306682527065277,
-0.2853161096572876,
0.03165486827492714,
-0.04648987576365471,
0.22079981863498688,
-0.0627191886305809,
0.12935718894004822,
-0.037302903831005096,
0.09412094205617905,
-0.05085102841258049,
0.08958800137042999,
0.1214100569486618,
0.177541121840477,
-0.13319164514541626,
-0.25089603662490845,
-0.1300327628850937,
0.19609734416007996,
-0.007119042333215475,
-0.2234649956226349,
-0.10254154354333878,
-0.340648889541626,
0.040642622858285904,
0.16830724477767944,
-0.004479698371142149,
-0.17619237303733826,
-0.14605353772640228,
0.22241127490997314,
-0.0891207754611969,
0.03565044328570366,
0.1357065737247467,
0.08203840255737305,
-0.20207618176937103,
0.07343756407499313,
-0.06928571313619614,
0.05605299025774002,
-0.14356689155101776,
-0.08288638293743134,
0.07803972065448761,
0.003032892942428589,
-0.07169746607542038,
0.10018321126699448,
-0.3905797302722931,
-0.18342311680316925,
-0.10524123162031174,
0.0741242989897728,
-0.17438900470733643,
-0.04048793762922287,
-0.08571553975343704,
0.18583866953849792,
-0.11568732559680939,
0.003361705457791686,
0.09691664576530457,
0.16753481328487396,
0.053883593529462814,
0.06158087030053139,
0.10684457421302795,
0.02174186147749424,
-0.12118081748485565,
0.13061916828155518,
0.054192494601011276,
-0.001777893165126443,
0.10986063629388809,
0.12573976814746857,
-0.10098633170127869,
-0.05721808224916458,
-0.1109740138053894,
0.14631947875022888,
0.18949097394943237,
-0.10565445572137833,
0.08626312762498856,
-0.0854032039642334,
0.02181253768503666,
0.09109561145305634,
0.07120577245950699,
0.022732123732566833,
0.01354717556387186,
-0.19412729144096375,
-0.06170612946152687,
0.036179665476083755,
0.30680620670318604,
0.0674487054347992,
-0.12132982909679413,
0.05926011875271797,
0.02752079628407955,
-0.09238245338201523,
0.14815004169940948,
-0.02807890810072422,
-0.07732216268777847,
0.11615286022424698,
-0.16781754791736603,
0.031084714457392693,
-0.05603041499853134,
0.0818849429488182,
0.19653920829296112,
-0.03181138634681702,
-0.023611467331647873,
0.044421203434467316,
-0.1326022893190384,
-0.25255587697029114,
-0.24696996808052063,
0.1324400007724762,
-0.05747104436159134,
0.12822484970092773,
0.1712534874677658,
0.13504911959171295,
0.00791519321501255,
0.11888390779495239,
0.17140106856822968,
0.13886110484600067,
-0.1382901668548584,
-0.104121632874012,
-0.06564031541347504,
0.10726159811019897,
-0.14538919925689697,
0.04692392796278,
0.14019547402858734,
-0.09076936542987823,
-0.03738285228610039,
-0.06110524386167526,
0.3586803078651428,
-0.09234641492366791,
0.15527094900608063,
0.11834464967250824,
0.08912500739097595,
0.12441327422857285,
-0.08592338114976883,
0.13256162405014038,
0.09174816310405731,
0.04050756245851517,
0.1408461034297943,
-0.09043444693088531,
-0.061617039144039154,
-0.13276071846485138,
0.027426933869719505,
0.09549446403980255,
0.0765201672911644,
0.09498395770788193,
0.19652384519577026,
-0.05641057714819908,
0.017257073894143105,
0.035182222723960876,
-0.03680255264043808,
0.14775851368904114,
0.0012039289576932788,
-0.24782797694206238,
-0.07395824044942856,
-0.13247185945510864,
0.07006610929965973,
0.15339365601539612,
0.016556251794099808,
-0.07591468095779419,
0.1480034440755844,
0.14291074872016907,
-0.07386554777622223,
-0.0029724366031587124,
-0.07003553211688995,
0.1831168383359909,
-0.16912943124771118,
-0.03751665726304054,
0.08958286792039871,
-0.13115429878234863,
-0.18864144384860992,
-0.10122766345739365,
-0.22275328636169434,
0.036198604851961136,
-0.07538287341594696,
-0.15337476134300232,
-0.00855366699397564,
0.11693908274173737,
-0.06557013094425201,
0.061037883162498474,
-0.04196060076355934,
-0.03204645961523056,
0.1287546306848526,
-0.21556060016155243,
0.14196515083312988,
0.026198241859674454,
-0.07300659269094467,
0.07776223123073578,
-0.059895142912864685,
0.10814084112644196,
0.3977023661136627,
0.028634797781705856,
0.1158304363489151,
-0.04364258050918579,
-0.2165658175945282,
-0.08182733505964279,
0.03692552447319031,
-0.10887406021356583,
-0.10814632475376129,
0.0023102732375264168,
-0.21448954939842224,
-0.05079452320933342,
-0.10747720301151276,
-0.08443240076303482,
0.15066373348236084,
-0.20492768287658691,
-0.12662047147750854,
-0.0890296995639801,
0.21344314515590668,
0.1390056014060974,
-0.059346720576286316,
-0.1543525606393814,
0.05639094486832619,
0.10918476432561874,
0.15173517167568207,
0.0339042954146862,
0.09765397757291794,
0.09485126286745071,
0.0245332270860672,
-0.10586400330066681,
0.11480318009853363,
0.1855820268392563,
0.151140034198761,
-0.035832613706588745,
0.0005319125484675169,
-0.3272700011730194,
-0.18041926622390747,
-0.010428137145936489,
-0.10765150189399719,
0.06449119746685028,
-0.11990807950496674,
-0.1793205887079239,
0.1126476526260376,
0.16868579387664795,
0.15532611310482025,
-0.15335024893283844,
0.08025342971086502,
-0.21582220494747162,
0.006782271899282932,
-0.06569336354732513,
-0.12741383910179138,
-0.16351550817489624,
0.0780126079916954,
0.008685282431542873,
0.19112645089626312,
-0.0501948818564415,
0.025747964158654213,
0.04287327453494072,
-0.0933268591761589,
0.08434400707483292,
0.12967169284820557,
-0.11057882010936737,
0.06602605432271957,
-0.04481818154454231,
0.12152764201164246,
0.22493700683116913,
-0.05922643840312958,
-0.08122147619724274,
0.028196819126605988,
-0.0728021040558815,
0.013404653407633305,
0.035060737282037735,
0.07304849475622177,
-0.07001615315675735,
0.009166790172457695,
0.014970803633332253,
0.1793699860572815,
-0.07393663376569748,
0.02864029072225094,
-0.07209090888500214,
0.04640627279877663,
0.14455415308475494,
0.07338552176952362,
-0.0557674914598465,
-0.11815963685512543,
-0.21756403148174286,
0.05086357146501541,
0.0014232115354388952,
0.008565389551222324,
0.13439612090587616,
0.23948292434215546,
-0.018955321982502937,
-0.12981249392032623,
-0.3241618573665619,
0.08451350033283234,
0.11326010525226593,
0.008224613033235073,
-0.03861982002854347,
0.09718360751867294,
0.1405443400144577,
0.3102331757545471,
0.03919428959488869,
0.13088785111904144,
0.18845447897911072,
0.029211653396487236,
-0.25353601574897766,
-0.04337378591299057,
-0.1279830038547516,
0.020669125020503998,
-0.19720831513404846,
0.1302124559879303,
-0.010829182341694832,
0.11829079687595367,
-0.04124043881893158,
-0.12511470913887024,
0.1296161562204361,
0.026506910100579262,
0.24036216735839844,
-0.14859487116336823,
-0.08421789109706879,
0.19269976019859314,
0.08467099070549011,
-0.3983534276485443,
-0.0310076754540205,
0.05288630723953247,
-0.0900232121348381,
0.05605652928352356,
0.020597457885742188,
-0.09871447086334229,
0.08904530107975006,
-0.13609161972999573,
-0.021511202678084373,
-0.08667910099029541,
-0.15761514008045197,
-0.19808490574359894,
0.2303229570388794,
0.09968540817499161,
0.16146232187747955,
0.12380391359329224,
0.012400023639202118,
0.08907455205917358,
-0.15147344768047333,
0.06990797072649002,
0.09321895241737366,
-0.016081171110272408,
0.1260042041540146,
-0.22132337093353271,
-0.08471601456403732,
0.04663173854351044,
0.23331588506698608,
0.06675543636083603,
0.055250994861125946,
0.14949843287467957,
-0.002857983112335205,
0.13652387261390686,
0.04647311940789223,
0.19848883152008057,
0.020840859040617943,
0.14501690864562988,
-0.22764043509960175,
-0.23797310888767242,
0.038395997136831284,
-0.00034623523242771626,
-0.03693120926618576,
-0.08924353122711182,
0.02184058167040348,
0.2064715176820755,
-0.11018083244562149,
0.03694959729909897,
0.07162385433912277,
-0.2509358525276184,
-0.01852315478026867,
-0.004390886519104242,
0.02601376548409462,
0.09962956607341766,
0.02617219276726246,
0.18473660945892334,
-0.0022665783762931824,
-0.023430900648236275,
-0.044631462544202805,
0.038590122014284134,
-0.10227908939123154,
-0.16988977789878845,
0.11530929803848267,
0.22562488913536072,
0.06590095907449722,
0.01584876887500286,
-0.01775066740810871,
0.1440506875514984,
0.09118342399597168,
0.12361596524715424,
0.030050482600927353,
0.07292743772268295,
0.0627421960234642,
-0.03887886181473732,
-0.03396710380911827,
-0.1273861527442932,
-0.1764671951532364,
0.00841060932725668,
0.002198886126279831,
-0.04370548576116562,
0.0031858489383012056,
0.09490396827459335,
0.09388155490159988,
-0.028922149911522865,
-0.11765816807746887,
0.02995067462325096,
-0.14062657952308655,
-0.02324720099568367,
0.09653489291667938,
-0.03552164509892464,
0.08418941497802734,
0.08544605225324631,
-0.17388282716274261,
0.09462768584489822,
-0.10288631170988083,
0.0932450219988823,
0.17311669886112213,
-0.06233678013086319,
0.06494016200304031,
-0.05910205468535423,
0.11191121488809586,
-0.028993073850870132,
-0.09266789257526398,
0.05861855298280716,
-0.056982122361660004,
0.141626238822937,
0.21470075845718384,
0.08629144728183746,
0.047931425273418427,
-0.018642757087945938,
0.06220632791519165,
-0.09742956608533859,
-0.18400928378105164,
-0.13246969878673553,
0.0726834312081337,
0.1271059364080429,
-0.010788945481181145,
-0.25048214197158813,
-0.02808246575295925,
-0.20897823572158813,
-0.2707127332687378,
0.19114567339420319,
0.16724005341529846,
0.03216901421546936,
-0.07107094675302505,
-0.018385881558060646,
0.026962142437696457,
-0.004457677248865366,
0.23912878334522247,
0.049847520887851715,
0.14457347989082336,
0.057905808091163635,
0.03328797221183777,
0.06532516330480576,
-0.08405539393424988,
0.005888140294700861,
0.031663041561841965,
0.007743249647319317,
0.02548510581254959,
0.10750570148229599,
-0.06299974769353867,
-0.2847244143486023,
-0.0858641266822815,
-0.05041929706931114,
-0.12913790345191956,
0.20890593528747559,
-0.1658768355846405,
-0.02681492641568184,
0.0008256397559307516,
-0.16974367201328278,
-0.07902717590332031,
0.15366700291633606,
0.013862065970897675,
0.2954225242137909,
-0.0435921810567379,
-0.2759290337562561,
-0.1372634768486023,
-0.15358862280845642,
-0.11142650246620178,
-0.05041946843266487,
-0.10449715703725815,
0.2628920078277588,
-0.019249165430665016,
0.08283741027116776,
-0.11651474237442017,
-0.20920871198177338,
0.0426173061132431,
-0.10081551969051361,
-0.0013179313391447067,
0.13457736372947693,
-0.1788187474012375,
-0.013203559443354607,
0.026810327544808388,
0.05394398793578148,
-0.03260427713394165,
-0.24062858521938324,
-0.04255398362874985,
0.03199607878923416,
0.015102842822670937,
-0.02193596214056015,
0.16232930123806,
-0.00131792644970119,
0.1864350140094757,
0.05892490968108177,
0.09162367135286331,
-0.22032666206359863,
-0.003272712230682373,
0.13614100217819214,
-0.015956174582242966,
-0.2572592496871948,
-0.04324113950133324,
-0.12900058925151825,
-0.030906258150935173,
0.057708173990249634,
0.22191716730594635,
0.11903930455446243,
-0.024098487570881844,
-0.16215446591377258,
-0.3339175581932068,
-0.16517144441604614,
-0.10759658366441727,
-0.04255838692188263,
0.15185068547725677,
-0.06774739921092987,
-0.09733431041240692,
0.06331779062747955,
0.0031012697145342827,
0.2642250061035156,
0.13785472512245178,
0.031082162633538246,
-0.005579467862844467,
-0.15703780949115753,
0.08506765216588974,
-0.009761004708707333,
0.011449608020484447,
-0.16787074506282806,
0.11731071770191193,
-0.07687562704086304,
-0.09870949387550354,
0.10771011561155319,
-0.0715581402182579,
0.045939184725284576,
-0.19379961490631104,
-0.08387675136327744,
0.04710494726896286,
0.12854887545108795,
0.044567905366420746,
-0.10746291279792786,
0.13340628147125244,
0.09564278274774551,
-0.08800448477268219,
0.05105605348944664,
0.200552836060524,
0.03139756619930267,
-0.1465991586446762,
0.09546209126710892,
-0.09923122078180313,
-0.2796480655670166,
-0.10349554568529129,
-0.04769554361701012,
0.055186424404382706,
-0.1646927148103714,
0.10785045474767685,
-0.1353393793106079,
0.055137600749731064,
0.09863654524087906,
-0.11115133762359619,
0.09384274482727051,
0.1058603972196579,
-0.14404822885990143,
-0.15490736067295074,
-0.12898904085159302,
0.1525731235742569,
0.006922340020537376,
0.12308719754219055,
-0.19074426591396332,
0.16546370089054108,
-0.07145805656909943,
-0.05651066079735756,
-0.14547112584114075,
-0.021129056811332703,
0.12152262777090073,
-0.13857942819595337,
-0.09095113724470139,
-0.029319224879145622,
-0.011946023441851139,
0.13648967444896698,
-0.2776825726032257,
0.03913508728146553,
-0.04201354831457138,
-0.14199522137641907,
-0.006000317633152008,
0.2150951623916626,
-0.06774590164422989,
0.11167796701192856,
0.09149099141359329,
0.2755626142024994,
-0.06678713113069534,
0.23614402115345,
-0.13719390332698822,
0.25133833289146423,
-0.07116947323083878,
0.01012694463133812,
-0.2688301205635071,
-0.030950145795941353,
0.1717231273651123,
-0.0672803521156311,
-0.0008480547112412751,
0.07318563014268875,
-0.17525282502174377,
0.07688630372285843,
0.24814538657665253,
0.0691605657339096,
0.04231037199497223,
-0.10682106763124466,
0.1171208918094635,
-0.1445266604423523,
-0.14156165719032288,
-0.170121431350708,
0.013633191585540771,
-0.10911069065332413,
0.11840415000915527,
-0.16265808045864105,
0.1265774965286255,
-0.140492781996727,
0.02938472293317318,
-0.11375230550765991,
-0.19723372161388397,
-0.056392885744571686,
-0.10331051051616669,
-0.07125815004110336,
0.16186897456645966,
-0.09840749949216843,
0.16037312150001526,
0.3392069935798645,
-0.05585286766290665,
0.2190639227628708,
0.005008837673813105,
0.21177899837493896,
-0.168143168091774,
-0.034801725298166275,
-0.12016112357378006,
-0.026035917922854424,
0.02034258283674717,
0.0815448984503746,
0.11451511830091476,
0.05389527603983879,
0.0539059042930603,
0.10892074555158615,
-0.20743682980537415,
-0.25416287779808044,
-0.05138635262846947,
-0.08259166032075882,
-0.057274315506219864,
0.18269822001457214,
0.09104999154806137,
0.015937872231006622,
0.2871618866920471,
-0.13408508896827698,
0.216364786028862,
-0.0019923648796975613,
-0.2000845968723297,
-0.20192813873291016,
-0.07954169809818268,
-0.10806094855070114,
-0.025252358987927437,
-0.023739341646432877,
-0.018038427457213402,
0.1329614520072937,
-0.04826265573501587,
0.034573156386613846,
-0.0254964716732502,
0.00697296392172575,
0.20113691687583923,
-0.0840471163392067,
0.05388297140598297,
0.2620898187160492,
-0.16576607525348663,
-0.39434677362442017,
-0.14930497109889984,
-0.04239087551832199,
-0.08411312103271484,
0.05312272906303406,
0.20011723041534424,
-0.15436431765556335,
-0.081582210958004,
0.2297060340642929,
-0.0832962915301323,
0.015368643216788769,
-0.11124763637781143,
-0.18170976638793945,
-0.09354060143232346,
-0.01431184634566307,
-0.02930731512606144,
-0.17852795124053955,
0.09381710737943649,
-0.06272298097610474,
0.1929597556591034,
0.009263531304895878,
-0.3033350706100464,
0.08452679216861725,
0.007811469025909901,
-0.011085049249231815,
-0.1630479097366333,
0.09409453719854355,
-0.0034539129119366407,
-0.24191083014011383,
0.2474069744348526,
0.1859920620918274,
-0.050536371767520905,
-0.11120618134737015,
-0.04788590595126152,
-0.3777139484882355,
-0.15412724018096924,
-0.08025802671909332,
-0.00828575063496828,
0.05588410422205925,
0.004415948409587145,
0.025228919461369514,
-0.20811311900615692,
-0.00924601312726736,
0.003492176765576005,
0.04999707639217377,
-0.20465674996376038,
0.06975109130144119,
0.07989047467708588,
0.036353252828121185,
-0.2445032149553299,
-0.08115486055612564,
-0.08520476520061493,
0.15261884033679962,
0.11583960801362991,
0.056626588106155396,
-0.04718411713838577,
-0.058437447994947433,
-0.10082268714904785,
-0.15598560869693756,
-0.12055349349975586,
0.06067996099591255,
-0.05536653846502304,
-0.02449965290725231,
-0.1375441998243332,
-0.04731110483407974,
0.06344111263751984,
-0.11246524006128311,
0.29800206422805786,
0.009682596661150455,
0.0831817016005516
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. ; thus, clinicians need to determine which multigene panel is most likely to identify the genetic cause of the condition at the most reasonable cost while limiting identification of variants of uncertain significance and pathogenic variants in genes that do not explain the underlying phenotype. (3) In some laboratories, panel options may include a custom laboratory-designed panel and/or custom phenotype-focused exome analysis that includes genes specified by the clinician. (4) Methods used in a panel may include sequence analysis, deletion/duplication analysis, and/or other non-sequencing-based tests.For an introduction to multigene panels click here. More detailed information for clinicians ordering genetic tests can be found here.More comprehensive genomic testing (when available) including exome sequencing and genome sequencing may be considered if serial single-gene testing (and/or use of a multigene panel that includes PCCA and PCCB) fails to confirm a diagnosis in an individual with features of propionic acidemia. Such testing may provide | [
-0.012115862220525742,
0.11346187442541122,
-0.05720556154847145,
-0.307420015335083,
0.055320847779512405,
-0.09673336148262024,
0.24149538576602936,
-0.18502160906791687,
0.029800282791256905,
0.06809704005718231,
0.21696220338344574,
0.047029048204422,
0.01322223711758852,
0.012211623601615429,
-0.3044530749320984,
0.14661766588687897,
0.1745227426290512,
-0.11212670803070068,
-0.020329415798187256,
-0.00789584033191204,
0.12361542135477066,
-0.10536439716815948,
0.12153416126966476,
0.06115533411502838,
0.15410682559013367,
-0.13462573289871216,
0.19764873385429382,
-0.13245834410190582,
0.1806260645389557,
-0.032488785684108734,
-0.05030735582113266,
-0.10448186844587326,
-0.03917549178004265,
-0.24429646134376526,
-0.1544589251279831,
-0.2737937271595001,
0.015203209593892097,
-0.14645099639892578,
0.06656147539615631,
-0.33869174122810364,
0.04882257059216499,
-0.10614433884620667,
0.29521653056144714,
-0.1250491440296173,
0.1706312745809555,
0.008272313512861729,
0.07939998805522919,
-0.10289598256349564,
0.043806299567222595,
0.11415160447359085,
0.19619107246398926,
-0.20509904623031616,
-0.17563235759735107,
-0.14699672162532806,
0.15606923401355743,
-0.08095778524875641,
-0.22757750749588013,
-0.07938865572214127,
-0.26898831129074097,
-0.04834422841668129,
0.15352630615234375,
0.016267135739326477,
-0.19015663862228394,
-0.12844255566596985,
0.24493974447250366,
-0.13846978545188904,
0.025220980867743492,
0.12319093942642212,
0.05245741456747055,
-0.1907065212726593,
0.10226024687290192,
-0.01824735291302204,
0.10368473827838898,
-0.10910975188016891,
-0.10481610149145126,
0.08617782592773438,
-0.007464572321623564,
-0.11812310665845871,
0.1578437238931656,
-0.42225217819213867,
-0.23267070949077606,
-0.09745782613754272,
0.04200669750571251,
-0.16497883200645447,
-0.06333276629447937,
-0.03270948305726051,
0.17598780989646912,
-0.028759745880961418,
0.022727319970726967,
0.14487740397453308,
0.1925872266292572,
0.09369592368602753,
0.046376727521419525,
0.0879838690161705,
-0.023648399859666824,
-0.10790091007947922,
0.13533559441566467,
-0.00209606159478426,
-0.09175092726945877,
0.11775988340377808,
0.1622161716222763,
-0.041143693029880524,
-0.034940287470817566,
-0.09055738896131516,
0.05885927751660347,
0.14900493621826172,
-0.12688931822776794,
0.06275713443756104,
-0.06480136513710022,
0.0867643654346466,
0.14366526901721954,
0.07402573525905609,
0.04547707363963127,
-0.013063108548521996,
-0.2357943207025528,
-0.05406086891889572,
-0.010224117897450924,
0.2984040677547455,
0.06516961753368378,
-0.1459287703037262,
0.06164081022143364,
-0.017033690586686134,
-0.11283909529447556,
0.0972343236207962,
-0.015809621661901474,
-0.0339488759636879,
0.0977730005979538,
-0.1430133730173111,
0.060003042221069336,
-0.09370646625757217,
0.07433865964412689,
0.15732282400131226,
-0.03043758124113083,
-0.01141501497477293,
0.0519803911447525,
-0.17531365156173706,
-0.2846912443637848,
-0.29753193259239197,
0.0631200447678566,
-0.05141669511795044,
0.10811879485845566,
0.18966735899448395,
0.18813540041446686,
0.06711990386247635,
0.06510351598262787,
0.17331376671791077,
0.16125217080116272,
-0.17425987124443054,
-0.120102159678936,
-0.11467467248439789,
0.11006130278110504,
-0.1411087065935135,
0.07084453850984573,
0.10956023633480072,
-0.11022652685642242,
-0.039567455649375916,
-0.10227707028388977,
0.4028645157814026,
-0.09405633807182312,
0.14923648536205292,
0.13019084930419922,
0.050125811249017715,
0.030355796217918396,
-0.07143281400203705,
0.10556535422801971,
0.0770912766456604,
-0.0067400820553302765,
0.13956108689308167,
-0.10421973466873169,
0.0023200807627290487,
-0.12870515882968903,
0.013555319048464298,
0.1752764731645584,
0.08669508993625641,
0.14369229972362518,
0.16735805571079254,
-0.02671136148273945,
0.02704128436744213,
0.08293605595827103,
0.05912206694483757,
0.09952773153781891,
0.004607116337865591,
-0.32144466042518616,
-0.05820702388882637,
-0.13941335678100586,
0.06325283646583557,
0.18959665298461914,
0.028211064636707306,
-0.021488022059202194,
0.09903747588396072,
0.08928652852773666,
-0.10775446146726608,
0.09177105128765106,
-0.10484226047992706,
0.18598082661628723,
-0.11080490797758102,
-0.04400239512324333,
0.07536731660366058,
-0.1379578858613968,
-0.17159569263458252,
-0.08281904458999634,
-0.2109580934047699,
0.09679710865020752,
-0.06276299804449081,
-0.14606045186519623,
-0.0855083242058754,
0.14227674901485443,
-0.016267314553260803,
0.09023766964673996,
-0.04017026349902153,
-0.024319909512996674,
0.15916500985622406,
-0.2929154336452484,
0.17400537431240082,
-0.0201776921749115,
-0.11640679091215134,
0.06338489800691605,
-0.11668875068426132,
0.10135344415903091,
0.3669266104698181,
0.0788920447230339,
0.17347832024097443,
0.04387343302369118,
-0.24291296303272247,
-0.09903501719236374,
0.13205304741859436,
-0.16686800122261047,
-0.13799570500850677,
0.04848124459385872,
-0.195543572306633,
-0.022982347756624222,
-0.03877340257167816,
-0.032900068908929825,
0.18288537859916687,
-0.24500581622123718,
-0.16281795501708984,
-0.153006449341774,
0.21465051174163818,
0.12591537833213806,
-0.02921815775334835,
-0.1843864917755127,
0.09426125884056091,
0.12158507853746414,
0.17455722391605377,
-0.01941498927772045,
0.15327540040016174,
0.020150229334831238,
0.013306916691362858,
-0.13197451829910278,
0.09631679207086563,
0.17620500922203064,
0.1124776154756546,
-0.03593434393405914,
-0.02750643901526928,
-0.29716095328330994,
-0.2531193196773529,
0.004652589559555054,
-0.107698455452919,
0.11458167433738708,
-0.192167267203331,
-0.2138199806213379,
0.03754138946533203,
0.16670294106006622,
0.18430159986019135,
-0.13428351283073425,
0.01774926669895649,
-0.20683781802654266,
0.0032311652321368456,
-0.036513183265924454,
-0.09999704360961914,
-0.16579276323318481,
0.016175616532564163,
0.027925314381718636,
0.16263476014137268,
-0.09919776767492294,
0.0037331576459109783,
0.01643451303243637,
-0.07171908766031265,
-0.007726162672042847,
0.11989723891019821,
-0.1382753700017929,
0.0891318991780281,
-0.03600453585386276,
0.09107138961553574,
0.18799293041229248,
0.00484395120292902,
-0.13413451611995697,
0.04108385741710663,
-0.08113972842693329,
-0.0005770514253526926,
0.023952621966600418,
0.14813029766082764,
-0.044022198766469955,
0.0075149014592170715,
0.032871320843696594,
0.1811646819114685,
-0.10460773855447769,
-0.03578576445579529,
-0.06481147557497025,
0.050850044935941696,
0.12234685570001602,
0.013629893772304058,
-0.03200201690196991,
-0.17619693279266357,
-0.26345834136009216,
0.06052148714661598,
0.0206180140376091,
0.020162727683782578,
0.07514142990112305,
0.21229764819145203,
-0.035691265016794205,
-0.13526445627212524,
-0.29759255051612854,
0.09080854803323746,
0.020986787974834442,
-0.06139824166893959,
-0.029422389343380928,
0.16181433200836182,
0.14862436056137085,
0.2876113951206207,
-0.011661432683467865,
0.13709747791290283,
0.19097131490707397,
0.051970891654491425,
-0.20958805084228516,
-0.06303716450929642,
-0.13881492614746094,
0.04553133249282837,
-0.21313682198524475,
0.16242046654224396,
-0.014259365387260914,
0.10043302923440933,
-0.003106958931311965,
-0.054423920810222626,
0.20220966637134552,
0.036109793931245804,
0.2066819965839386,
-0.14361971616744995,
-0.09134972840547562,
0.20748475193977356,
0.10359198600053787,
-0.4170973002910614,
0.01679410971701145,
0.022870421409606934,
-0.10419095307588577,
0.11402801424264908,
0.05542922019958496,
0.007920727133750916,
0.04341377317905426,
-0.15864597260951996,
-0.08753533661365509,
-0.06697235256433487,
-0.05555031821131706,
-0.21010546386241913,
0.23942118883132935,
0.07740970700979233,
0.10646434873342514,
0.10638560354709625,
0.028736330568790436,
0.02358049713075161,
-0.12666600942611694,
0.08556368201971054,
0.11951970309019089,
0.0032456896733492613,
0.19423185288906097,
-0.09339116513729095,
-0.0543324239552021,
0.07820448279380798,
0.2471892237663269,
0.04653982073068619,
0.02143385447561741,
0.09012217074632645,
0.011901536956429482,
0.09832804650068283,
0.013502704910933971,
0.15252023935317993,
0.01544874720275402,
0.1832483857870102,
-0.2467201054096222,
-0.26686930656433105,
0.015162563882768154,
-0.001093367231078446,
-0.031970053911209106,
-0.128819540143013,
0.05975613743066788,
0.2613756060600281,
-0.06696813553571701,
0.006897743791341782,
0.15091653168201447,
-0.3088928461074829,
-0.013036387041211128,
0.029963897541165352,
0.10358229279518127,
0.0750756487250328,
-0.041263967752456665,
0.1291065812110901,
0.026362299919128418,
-0.00046504626516252756,
-0.04828565567731857,
-0.03314458951354027,
-0.08809683471918106,
-0.11723869293928146,
0.10519326478242874,
0.2028779834508896,
0.007776043843477964,
0.01533549651503563,
0.014937677420675755,
0.1937868893146515,
0.011695239692926407,
0.15514415502548218,
0.04404111206531525,
0.04097369313240051,
0.03532829135656357,
-0.02522527612745762,
-0.02325398661196232,
-0.11511380970478058,
-0.13090170919895172,
0.058447517454624176,
0.08640113472938538,
-0.01991802453994751,
0.012086142785847187,
0.07113533467054367,
0.16006912291049957,
-0.03218628466129303,
-0.09354769438505173,
0.07476767152547836,
-0.1264476180076599,
-0.02973896637558937,
0.02540004625916481,
-0.005931980907917023,
0.0800558477640152,
0.02486923523247242,
-0.13185763359069824,
0.1087140366435051,
-0.025827864184975624,
0.11585209518671036,
0.11114150285720825,
-0.07245742529630661,
0.024837881326675415,
-0.07919829338788986,
0.10844430327415466,
-0.07154300808906555,
-0.06362123787403107,
0.0791492611169815,
-0.0879102423787117,
0.16546837985515594,
0.23487547039985657,
-0.005888262297958136,
0.02127080410718918,
0.041810307651758194,
0.05405275896191597,
-0.08909996598958969,
-0.2657778561115265,
-0.1328514665365219,
0.08029283583164215,
0.1540934294462204,
-0.015029599890112877,
-0.2699027955532074,
-0.02596128359436989,
-0.17539072036743164,
-0.21630661189556122,
0.15152588486671448,
0.19299060106277466,
0.00563034089282155,
-0.12458327412605286,
0.08384934812784195,
-0.058271389454603195,
-0.0038271069061011076,
0.2565076947212219,
0.1416686773300171,
0.15468692779541016,
0.05149292200803757,
0.0667424127459526,
0.11428587138652802,
-0.19243073463439941,
-0.005906373728066683,
0.06716050952672958,
-0.0046502514742314816,
0.012818602845072746,
0.0943756029009819,
-0.09911812841892242,
-0.19116386771202087,
-0.0422329381108284,
-0.015550842508673668,
-0.1604161411523819,
0.20334048569202423,
-0.10908769071102142,
-0.10414399206638336,
-0.07178844511508942,
-0.13391441106796265,
-0.11204566061496735,
0.1462896466255188,
-0.03240794315934181,
0.23497147858142853,
-0.07736935466527939,
-0.27282682061195374,
-0.13706016540527344,
-0.1564507931470871,
-0.15415407717227936,
-0.06587802618741989,
-0.06320971995592117,
0.2353169322013855,
-0.05197460576891899,
0.11698709428310394,
-0.09948650002479553,
-0.17495940625667572,
-0.011770376935601234,
-0.04361351206898689,
-0.0044354223646223545,
0.0752735435962677,
-0.13079731166362762,
0.07582485675811768,
0.07792899012565613,
0.021978257223963737,
-0.039260752499103546,
-0.23850667476654053,
-0.01926267147064209,
0.06628089398145676,
0.033487699925899506,
-0.05879998207092285,
0.1164732500910759,
0.022254658862948418,
0.22712717950344086,
0.09930874407291412,
0.02774318866431713,
-0.1845880001783371,
0.038075290620326996,
0.14327000081539154,
0.07461804896593094,
-0.24265162646770477,
-0.013737672939896584,
-0.14448842406272888,
-0.10341176390647888,
-0.027607925236225128,
0.2939516305923462,
0.09186778962612152,
0.003580700373277068,
-0.23322448134422302,
-0.2945254147052765,
-0.22688770294189453,
-0.17068026959896088,
-0.0623222179710865,
0.14289292693138123,
-0.07544711232185364,
-0.1250368058681488,
0.03478356823325157,
0.03998446837067604,
0.2297571748495102,
0.12788422405719757,
0.02160792052745819,
-0.007353200577199459,
-0.16130240261554718,
0.12205278128385544,
0.07452239096164703,
-0.031156038865447044,
-0.26124659180641174,
0.033322807401418686,
-0.1220756396651268,
-0.1297728419303894,
0.060435086488723755,
-0.05588556453585625,
-0.0011923882411792874,
-0.19360315799713135,
-0.11146464198827744,
0.017312247306108475,
0.12339965254068375,
0.007895861752331257,
-0.06053031235933304,
0.05107320100069046,
0.14906136691570282,
-0.10519012063741684,
0.106690414249897,
0.1831287294626236,
-0.02185162901878357,
-0.16207613050937653,
0.14496365189552307,
-0.044450804591178894,
-0.32552826404571533,
-0.07721316814422607,
0.0014267308870330453,
0.07697216421365738,
-0.18107928335666656,
0.1892113983631134,
-0.16185739636421204,
0.05805175378918648,
0.10951188206672668,
-0.07698899507522583,
0.13545982539653778,
0.12392876297235489,
-0.20208756625652313,
-0.17204348742961884,
-0.13353388011455536,
0.1973728984594345,
0.051643647253513336,
0.10739247500896454,
-0.21292142570018768,
0.1840275079011917,
-0.019780544564127922,
-0.038005340844392776,
-0.10505180805921555,
-0.012387228198349476,
0.1467238813638687,
-0.14596399664878845,
-0.07435059547424316,
-0.05833417922258377,
0.018456732854247093,
0.11870536208152771,
-0.19191524386405945,
-0.010739520192146301,
-0.038972124457359314,
-0.07473313808441162,
-0.01434097159653902,
0.16954977810382843,
-0.09257286787033081,
0.13072261214256287,
0.10668564587831497,
0.24684734642505646,
-0.01683948189020157,
0.3328703045845032,
-0.16267381608486176,
0.2922150194644928,
-0.11660785973072052,
0.022464685142040253,
-0.20026293396949768,
0.004565688781440258,
0.16514632105827332,
-0.0442432276904583,
-0.043094079941511154,
0.08833962678909302,
-0.1905554234981537,
0.06997133046388626,
0.2823886275291443,
0.046193141490221024,
-0.021916799247264862,
-0.11104284971952438,
0.1438698023557663,
-0.16149766743183136,
-0.1143684983253479,
-0.16884399950504303,
0.05563568323850632,
-0.16217344999313354,
0.12026048451662064,
-0.19391772150993347,
0.0882527083158493,
-0.1571204662322998,
-0.003591820364817977,
-0.05177215486764908,
-0.2159588485956192,
-0.0667940154671669,
-0.06870748102664948,
-0.059946462512016296,
0.10108837485313416,
-0.054119646549224854,
0.22577640414237976,
0.33607974648475647,
-0.08490720391273499,
0.230958953499794,
0.019609598442912102,
0.1878901720046997,
-0.15149229764938354,
0.04270441457629204,
-0.09098878502845764,
0.03214314952492714,
0.07775940001010895,
0.04475202411413193,
0.1247885599732399,
0.0310683473944664,
0.03028065524995327,
0.060955148190259933,
-0.1269974410533905,
-0.22950370609760284,
-0.07911329716444016,
-0.1189698725938797,
-0.033077213913202286,
0.19447927176952362,
0.1267259567975998,
0.04537634551525116,
0.3275272250175476,
-0.18778574466705322,
0.11328476667404175,
-0.037879571318626404,
-0.26265591382980347,
-0.28340086340904236,
-0.07703465968370438,
-0.07347630709409714,
0.0599893257021904,
-0.0989028662443161,
-0.0055327643640339375,
0.21600688993930817,
-0.07898672670125961,
0.055777523666620255,
0.007459257263690233,
0.01880934275686741,
0.20755961537361145,
-0.06811676174402237,
0.07415485382080078,
0.2580806016921997,
-0.1777576357126236,
-0.34764009714126587,
-0.19653570652008057,
-0.060176119208335876,
-0.06294627487659454,
0.04471767321228981,
0.1830958127975464,
-0.13124170899391174,
-0.0437002070248127,
0.24057291448116302,
-0.11620134860277176,
0.07187965512275696,
-0.09988456964492798,
-0.19085267186164856,
-0.12823109328746796,
-0.01889721304178238,
-0.06423135101795197,
-0.12468398362398148,
0.09537363797426224,
-0.08871257305145264,
0.2199326455593109,
-0.07353223115205765,
-0.3176509439945221,
0.07269188016653061,
0.056191932410001755,
0.005199446342885494,
-0.18439853191375732,
0.08672124147415161,
-0.016925442963838577,
-0.20640461146831512,
0.2542700171470642,
0.12677808105945587,
0.03326832875609398,
-0.1241430938243866,
-0.05408746004104614,
-0.3815217614173889,
-0.12325335294008255,
-0.014943071641027927,
-0.008397567085921764,
0.08520232886075974,
0.06355192512273788,
-0.009601450525224209,
-0.1718459129333496,
-0.07054972648620605,
-0.010186625644564629,
0.043210797011852264,
-0.1545356959104538,
0.1224525049328804,
0.14090678095817566,
-0.03474191203713417,
-0.2343345731496811,
-0.07165843993425369,
-0.17637187242507935,
0.11316312104463577,
0.05692404881119728,
0.07062237709760666,
-0.08251307159662247,
-0.07989611476659775,
-0.04935796931385994,
-0.16758601367473602,
-0.09188433736562729,
0.0954926535487175,
-0.06245432794094086,
-0.06305965781211853,
-0.06211954727768898,
-0.0872243270277977,
0.094448983669281,
-0.1139121726155281,
0.277851402759552,
0.02346421219408512,
0.11330629885196686
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , deletion/duplication analysis, and/or other non-sequencing-based tests.For an introduction to multigene panels click here. More detailed information for clinicians ordering genetic tests can be found here.More comprehensive genomic testing (when available) including exome sequencing and genome sequencing may be considered if serial single-gene testing (and/or use of a multigene panel that includes PCCA and PCCB) fails to confirm a diagnosis in an individual with features of propionic acidemia. Such testing may provide or suggest a diagnosis not previously considered (e.g., mutation of a different gene or genes that results in a similar clinical presentation). For an introduction to comprehensive genomic testing click here. More detailed information for clinicians ordering genomic testing can be found here.Table 1. Molecular Genetic Testing Used in Propionic AcidemiaView in own windowGene 1Proportion of PA Attributed to Pathogenic Variants in GeneProportion of Pathogenic Variants 2 Detected by Method 3Sequence analysis 4Gene- | [
-0.06416238844394684,
0.1366279274225235,
-0.027210548520088196,
-0.2944056987762451,
0.0840376615524292,
-0.04753703624010086,
0.1380285620689392,
-0.20659294724464417,
0.000938576995395124,
0.04998258501291275,
0.1043301448225975,
-0.01987157203257084,
-0.034170664846897125,
0.08790292590856552,
-0.27374449372291565,
0.11282658576965332,
0.20082686841487885,
-0.10370160639286041,
-0.020048929378390312,
-0.021242553368210793,
0.12227119505405426,
-0.07269105315208435,
0.12084188312292099,
0.07307752966880798,
0.2160324901342392,
-0.12754347920417786,
0.18686623871326447,
-0.24476833641529083,
0.17215904593467712,
-0.008438808843493462,
-0.009940305724740028,
-0.04109448194503784,
-0.00617774436250329,
-0.22025343775749207,
-0.06008681282401085,
-0.2872695028781891,
-0.000500416150316596,
-0.15463745594024658,
0.07031646370887756,
-0.30909380316734314,
0.06757398694753647,
-0.03727393224835396,
0.2984715700149536,
-0.039572492241859436,
0.1714114546775818,
0.026941368356347084,
0.017605800181627274,
-0.03968973457813263,
-0.01290792878717184,
0.13569003343582153,
0.21421733498573303,
-0.12787750363349915,
-0.21832498908042908,
-0.15606647729873657,
0.17713546752929688,
-0.09085006266832352,
-0.19090348482131958,
-0.036197204142808914,
-0.2750054895877838,
-0.08162533491849899,
0.11115451902151108,
-0.04819799214601517,
-0.17547431588172913,
-0.17711614072322845,
0.259268194437027,
-0.10493998229503632,
0.05010312795639038,
0.11882054060697556,
0.1208449974656105,
-0.19620676338672638,
0.14196868240833282,
-0.023307640105485916,
0.11867857724428177,
-0.0542655847966671,
-0.11681894212961197,
0.0776883065700531,
-0.021526146680116653,
-0.014247680082917213,
0.026066521182656288,
-0.3916148245334625,
-0.21616709232330322,
-0.02158697508275509,
0.07211384177207947,
-0.09250970929861069,
-0.0343213714659214,
-0.029708268120884895,
0.17315776646137238,
-0.016814472153782845,
-0.04173944890499115,
0.12669214606285095,
0.1442629098892212,
0.05334174633026123,
0.028403161093592644,
0.07500752061605453,
0.026947494596242905,
-0.13696299493312836,
0.17586970329284668,
-0.019923264160752296,
-0.09903969615697861,
0.056523434817790985,
0.10349597781896591,
0.018099036067724228,
-0.12841209769248962,
-0.1254885047674179,
0.025824829936027527,
0.09467756003141403,
-0.11490996181964874,
0.011024239473044872,
-0.07157452404499054,
0.046159472316503525,
0.17385031282901764,
-0.01854587346315384,
0.07292400300502777,
0.008452242240309715,
-0.3181878328323364,
0.005806470289826393,
-0.022592561319470406,
0.24620981514453888,
-0.010629762895405293,
-0.0206355731934309,
-0.010859902016818523,
0.015724876895546913,
-0.05781704932451248,
0.050310809165239334,
-0.06521713733673096,
0.03418371453881264,
0.07615560293197632,
-0.15906760096549988,
0.1262080818414688,
-0.11400846391916275,
0.05544371157884598,
0.1140044629573822,
0.021147925406694412,
-0.003051288891583681,
0.07721518725156784,
-0.10411663353443146,
-0.24893403053283691,
-0.2759917080402374,
0.03438194841146469,
-0.009272046387195587,
0.172247052192688,
0.2085396945476532,
0.1465369611978531,
0.09537361562252045,
0.14916588366031647,
0.19510948657989502,
0.2468196302652359,
-0.17041052877902985,
-0.047660619020462036,
-0.013327034190297127,
0.06805577129125595,
-0.21662509441375732,
0.1360003650188446,
0.0674331784248352,
-0.1256512552499771,
0.032950062304735184,
-0.023880954831838608,
0.3488713800907135,
-0.022477949038147926,
0.0440719872713089,
0.04413236305117607,
0.034322384744882584,
0.0426853746175766,
-0.07495420426130295,
0.09838196635246277,
0.06846275180578232,
-0.0844925194978714,
0.16368462145328522,
-0.04027653485536575,
0.011715427041053772,
-0.10589667409658432,
-0.015189209952950478,
0.11508393287658691,
0.13934741914272308,
0.093914695084095,
0.11277063935995102,
-0.11832264065742493,
0.02350103296339512,
0.07590309530496597,
0.12999586760997772,
0.15916042029857635,
0.03852839767932892,
-0.2653828561306,
-0.05503486469388008,
-0.15225954353809357,
0.007436904590576887,
0.21522890031337738,
0.0840064138174057,
-0.02716013416647911,
0.15738996863365173,
0.19029757380485535,
-0.1418786495923996,
-0.03539634495973587,
-0.04145512729883194,
0.1698378175497055,
-0.1904815435409546,
-0.028725996613502502,
0.05977402254939079,
-0.12778420746326447,
-0.15175870060920715,
-0.10776342451572418,
-0.17869159579277039,
0.043761905282735825,
-0.000091846777650062,
-0.061611127108335495,
-0.08126789331436157,
0.1332380771636963,
-0.1130402609705925,
0.027064522728323936,
-0.02710280381143093,
-0.06110547482967377,
0.2195500135421753,
-0.2755134403705597,
0.11437860876321793,
-0.07526149600744247,
-0.039501141756772995,
0.06480365991592407,
-0.13000544905662537,
0.07498245686292648,
0.26764050126075745,
-0.03211275115609169,
0.16133880615234375,
0.000622633786406368,
-0.20064625144004822,
-0.08827725797891617,
0.10761722177267075,
-0.2277899831533432,
-0.08214109390974045,
0.039565227925777435,
-0.2139907032251358,
-0.02375868894159794,
-0.03475042060017586,
0.007196808699518442,
0.1287107765674591,
-0.1706402748823166,
-0.15445862710475922,
-0.043162841349840164,
0.20143380761146545,
0.11975909024477005,
0.010466418229043484,
-0.20435340702533722,
0.06988739967346191,
0.11472799628973007,
0.0684402734041214,
0.045391831547021866,
0.03484005108475685,
-0.04351130127906799,
0.014742108061909676,
-0.14171503484249115,
0.11234068125486374,
0.0739370733499527,
0.08947902917861938,
-0.030630992725491524,
0.015885569155216217,
-0.3557364344596863,
-0.2785630226135254,
-0.0019807300996035337,
-0.12067639827728271,
0.07102584093809128,
-0.070731982588768,
-0.1104683056473732,
0.11591263860464096,
0.10778442025184631,
0.15053217113018036,
-0.11900276690721512,
-0.062111858278512955,
-0.2925063371658325,
-0.013443526811897755,
-0.05844999477267265,
-0.12664395570755005,
-0.14560385048389435,
0.07928922772407532,
0.041135694831609726,
0.14058375358581543,
-0.0991772934794426,
-0.02756795659661293,
0.038160502910614014,
0.02117213048040867,
-0.014818529598414898,
0.06934397667646408,
-0.1842900961637497,
0.1480100005865097,
-0.0458851084113121,
0.07456311583518982,
0.1929270625114441,
-0.1024998351931572,
-0.08547811210155487,
0.03754178434610367,
-0.1773597002029419,
0.026819655671715736,
0.033934202045202255,
0.14306485652923584,
-0.07012811303138733,
0.0028442165348678827,
0.1181703433394432,
0.19562478363513947,
0.0009163441136479378,
-0.03014248050749302,
-0.07420551031827927,
-0.006899700034409761,
0.16729308664798737,
-0.046456802636384964,
0.059978168457746506,
-0.18455664813518524,
-0.2510479986667633,
-0.010612325742840767,
0.12991654872894287,
-0.04479096829891205,
0.12409284710884094,
0.20033510029315948,
-0.05078059807419777,
-0.10233714431524277,
-0.3037404417991638,
0.0872713103890419,
-0.004265215247869492,
-0.055089183151721954,
-0.041782572865486145,
0.12619458138942719,
0.14628641307353973,
0.31687816977500916,
0.09717852622270584,
0.09392330050468445,
0.10505716502666473,
-0.0160385575145483,
-0.19895480573177338,
-0.06885622441768646,
-0.059410665184259415,
0.03024435043334961,
-0.13311117887496948,
0.14696383476257324,
0.03581228479743004,
0.10752284526824951,
-0.06131548434495926,
-0.034125957638025284,
0.27953487634658813,
-0.010554620996117592,
0.1987486630678177,
0.0020464882254600525,
-0.08755438774824142,
0.19494622945785522,
0.15615873038768768,
-0.4199807047843933,
-0.0006793230422772467,
-0.047322746366262436,
-0.13832372426986694,
0.054302509874105453,
-0.015155837871134281,
-0.010152298957109451,
0.07698669284582138,
-0.19776341319084167,
0.019942481070756912,
-0.06481865793466568,
0.022775957360863686,
-0.21251271665096283,
0.2997615337371826,
0.005962653551250696,
0.027701955288648605,
0.10112559795379639,
-0.017207760363817215,
0.03993101418018341,
-0.22329071164131165,
0.09491652250289917,
0.1636202037334442,
-0.04107678681612015,
0.10897152125835419,
-0.06863579154014587,
0.01997513882815838,
0.04926858842372894,
0.20073364675045013,
0.006640068721026182,
0.030624015256762505,
0.10260356962680817,
0.06769676506519318,
0.12632274627685547,
0.009264016523957253,
0.13535179197788239,
0.05324499309062958,
0.11507279425859451,
-0.2850756049156189,
-0.27644670009613037,
0.008016897365450859,
0.004438390024006367,
-0.03203520178794861,
-0.07843787968158722,
0.12027327716350555,
0.21241478621959686,
-0.10725695639848709,
0.043814390897750854,
0.16018177568912506,
-0.30550137162208557,
-0.006433963309973478,
-0.005560999736189842,
0.05185456573963165,
0.04709203913807869,
0.011423411779105663,
0.17170967161655426,
0.008650277741253376,
-0.0273709949105978,
-0.04858553409576416,
0.027728764340281487,
-0.08143247663974762,
-0.09696993231773376,
0.14280180633068085,
0.223507821559906,
0.02493678219616413,
0.03499159216880798,
0.019118359312415123,
0.1761891394853592,
-0.06222043186426163,
0.06659551709890366,
0.012500069104135036,
0.02690831385552883,
0.02042212150990963,
-0.10778079926967621,
-0.02190977707505226,
-0.09900393337011337,
-0.12152609974145889,
0.033819593489170074,
-0.005648571066558361,
0.06168278306722641,
0.029314985498785973,
0.11952536553144455,
0.06628391146659851,
-0.02829946018755436,
-0.09038788080215454,
0.06627207249403,
0.004020373802632093,
-0.04631027951836586,
0.03131232038140297,
-0.004821176640689373,
0.11488043516874313,
0.006465281825512648,
-0.1404140442609787,
0.02514253929257393,
0.0038368708919733763,
0.12695133686065674,
0.04688059166073799,
-0.0810488760471344,
-0.016155872493982315,
-0.04684458673000336,
0.11811873316764832,
-0.033937979489564896,
-0.13260984420776367,
0.005995628423988819,
-0.09835099428892136,
0.13005481660366058,
0.1453191190958023,
0.08387985080480576,
0.02809912897646427,
0.12877598404884338,
0.0720214694738388,
-0.05526145175099373,
-0.22533835470676422,
-0.05967441573739052,
0.050428349524736404,
0.0600188709795475,
-0.010814760811626911,
-0.2080824226140976,
0.04410134255886078,
-0.1778566837310791,
-0.1553249955177307,
0.1753520965576172,
0.19599224627017975,
-0.019340582191944122,
-0.17087145149707794,
0.06304290145635605,
-0.15406596660614014,
0.017210667952895164,
0.23763297498226166,
0.09461772441864014,
0.10608544945716858,
0.05775260180234909,
-0.0230123121291399,
0.03951461613178253,
-0.1599126011133194,
0.02143506146967411,
0.05440928041934967,
-0.02824605628848076,
0.0430380143225193,
0.12184562534093857,
-0.053401704877614975,
-0.20592181384563446,
0.024309411644935608,
-0.043609362095594406,
-0.19069316983222961,
0.22193175554275513,
-0.1173560842871666,
-0.11011423915624619,
-0.027781574055552483,
-0.11475829780101776,
-0.11723118275403976,
0.12859801948070526,
-0.032188780605793,
0.30306801199913025,
-0.13740909099578857,
-0.2632332444190979,
-0.08538666367530823,
-0.14725251495838165,
-0.08314001560211182,
-0.029808038845658302,
-0.12842708826065063,
0.11860073357820511,
0.00700595835223794,
0.18011333048343658,
-0.1126195564866066,
-0.06370391696691513,
-0.0747767761349678,
-0.11081808805465698,
0.03458289057016373,
0.15261118113994598,
-0.12121596932411194,
0.14690731465816498,
0.027969306334853172,
0.057867612689733505,
-0.019793596118688583,
-0.23252296447753906,
0.003914350178092718,
0.11205989122390747,
0.004237004555761814,
-0.12904439866542816,
0.11650792509317398,
-0.06791027635335922,
0.18843097984790802,
0.04059900343418121,
0.035818133503198624,
-0.19233064353466034,
0.07257883995771408,
0.18758685886859894,
0.09033519774675369,
-0.1846402883529663,
0.025485564023256302,
-0.1096516028046608,
-0.1386890709400177,
0.012642432935535908,
0.23247261345386505,
0.028671808540821075,
0.034382760524749756,
-0.25000178813934326,
-0.3054385185241699,
-0.1876707226037979,
-0.09964395314455032,
-0.07324539870023727,
0.10274815559387207,
-0.035371337085962296,
-0.11153224110603333,
0.08721386641263962,
0.08811165392398834,
0.19314789772033691,
0.1596779078245163,
0.009056061506271362,
0.016263611614704132,
-0.14773797988891602,
0.0751810073852539,
0.053952574729919434,
-0.09502754360437393,
-0.2511636018753052,
-0.057967476546764374,
-0.035950761288404465,
-0.12019999325275421,
0.03750314190983772,
-0.01668568328022957,
-0.04165489971637726,
-0.22617925703525543,
-0.01860252395272255,
0.01551670953631401,
0.11038888990879059,
0.0033805707935243845,
-0.09286252409219742,
0.06801365315914154,
0.038641463965177536,
-0.0836026519536972,
0.027670498937368393,
0.2214771956205368,
-0.03361295536160469,
-0.19323107600212097,
0.07892778515815735,
-0.15828675031661987,
-0.334916353225708,
-0.10614961385726929,
0.055918000638484955,
0.08362285047769547,
-0.1419333517551422,
0.15155106782913208,
-0.10176832228899002,
0.07958164066076279,
0.07416843622922897,
0.011905398219823837,
0.08294682204723358,
0.15957890450954437,
-0.19307294487953186,
-0.08261842280626297,
-0.12506435811519623,
0.098325714468956,
0.07552438974380493,
0.09795079380273819,
-0.21250677108764648,
0.20588235557079315,
-0.07513496279716492,
-0.017762118950486183,
-0.014765767380595207,
-0.02243148908019066,
0.15435360372066498,
-0.10737134516239166,
-0.13615940511226654,
0.0044473204761743546,
-0.07885824143886566,
0.14401575922966003,
-0.24173296988010406,
-0.015711599960923195,
-0.06998834013938904,
-0.0175720676779747,
0.012134999968111515,
0.13589631021022797,
-0.10633508116006851,
0.0875091403722763,
0.10856209695339203,
0.27021604776382446,
0.005140903405845165,
0.2341289073228836,
-0.19466224312782288,
0.26719164848327637,
-0.07337379455566406,
0.03903677314519882,
-0.15890707075595856,
-0.11738788336515427,
0.15956240892410278,
-0.07534650713205338,
-0.05786217749118805,
0.09142749756574631,
-0.09234688431024551,
0.07389920204877853,
0.2937453091144562,
-0.022874262183904648,
-0.07049057632684708,
-0.12945441901683807,
0.09856242686510086,
-0.042200855910778046,
-0.07999413460493088,
-0.11737724393606186,
0.09080374985933304,
-0.18489812314510345,
0.14810363948345184,
-0.13066239655017853,
0.09535634517669678,
-0.208184152841568,
-0.004087771754711866,
-0.06457357853651047,
-0.17371737957000732,
-0.051296766847372055,
-0.05047668144106865,
-0.0809415653347969,
0.11430605500936508,
-0.06997688859701157,
0.19703611731529236,
0.33232808113098145,
-0.12652257084846497,
0.24483932554721832,
-0.02639182284474373,
0.22937598824501038,
-0.17249496281147003,
-0.04052649065852165,
0.01831786520779133,
0.014946497045457363,
0.05891695246100426,
-0.0347236692905426,
0.10976208746433258,
0.05630406737327576,
-0.027483530342578888,
0.06461694836616516,
-0.1680290251970291,
-0.2493712455034256,
-0.055619046092033386,
-0.019100166857242584,
-0.01086070854216814,
0.09882903099060059,
0.14789870381355286,
-0.04633739963173866,
0.2449817806482315,
-0.11091569811105728,
0.14123369753360748,
0.0003509193775244057,
-0.2710669934749603,
-0.2062995731830597,
-0.01756708137691021,
-0.10921576619148254,
0.10686124116182327,
-0.10379983484745026,
-0.042672015726566315,
0.2053200751543045,
-0.10994365066289902,
0.06587827950716019,
-0.05848357081413269,
0.0946677103638649,
0.1652713567018509,
0.019168740138411522,
0.05344170331954956,
0.3083477020263672,
-0.14778408408164978,
-0.2511964738368988,
-0.19596537947654724,
-0.10716823488473892,
-0.08788613975048065,
0.04613198712468147,
0.10402724891901016,
-0.1142662987112999,
-0.07929834723472595,
0.23292449116706848,
-0.08500371128320694,
0.09920374304056168,
-0.07015562057495117,
-0.1440991461277008,
-0.10531418770551682,
-0.04595563933253288,
0.01641213521361351,
-0.15758754312992096,
0.19556164741516113,
-0.03394610434770584,
0.24880652129650116,
-0.10324686765670776,
-0.2040414661169052,
0.032108958810567856,
0.0268027912825346,
0.018209468573331833,
-0.1971358358860016,
0.08068490028381348,
-0.048318758606910706,
-0.17985616624355316,
0.18721365928649902,
0.20890739560127258,
-0.01989888586103916,
-0.10164594650268555,
-0.038322385400533676,
-0.3794082701206207,
-0.0015858160331845284,
-0.1048993244767189,
0.11463043093681335,
0.05203183367848396,
0.020077602937817574,
-0.04541737586259842,
-0.2644365131855011,
-0.05187943950295448,
0.0369521901011467,
0.07668977230787277,
-0.174160897731781,
0.0863967165350914,
0.1918763518333435,
-0.028414752334356308,
-0.20762215554714203,
-0.10530438274145126,
-0.1139516830444336,
0.16930152475833893,
0.11744142323732376,
0.023509928956627846,
-0.07088252156972885,
-0.04215509817004204,
-0.05153470113873482,
-0.13303594291210175,
-0.13085752725601196,
0.1263279765844345,
-0.08120764046907425,
-0.09485721588134766,
-0.03686557710170746,
-0.056411899626255035,
0.11203812807798386,
-0.14294248819351196,
0.21821102499961853,
0.020380061119794846,
0.06971634179353714
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. emia. Such testing may provide or suggest a diagnosis not previously considered (e.g., mutation of a different gene or genes that results in a similar clinical presentation). For an introduction to comprehensive genomic testing click here. More detailed information for clinicians ordering genomic testing can be found here.Table 1. Molecular Genetic Testing Used in Propionic AcidemiaView in own windowGene 1Proportion of PA Attributed to Pathogenic Variants in GeneProportion of Pathogenic Variants 2 Detected by Method 3Sequence analysis 4Gene-targeted deletion/duplication analysis 5PCCA50%78%18% 6PCCB50%97%3% 71. See Table A. Genes and Databases for chromosome locus and protein.2. See Molecular Genetics for information on allelic variants detected in this gene.3. Kraus et al reported no identifiable pathogenic variants in 7% (4/54) and one identifiable variant in 4% (2/54) of individuals with propionic acidemia. Some of | [
0.0006985554937273264,
0.1471317857503891,
0.09311332553625107,
-0.26845893263816833,
0.16868756711483002,
-0.06416130810976028,
0.06023212894797325,
-0.2756156027317047,
-0.04628501832485199,
0.01256802212446928,
0.030954482033848763,
0.01323714666068554,
-0.05069277063012123,
0.08110284805297852,
-0.2485034465789795,
0.04005231708288193,
0.1988736391067505,
-0.03343603014945984,
-0.02652827836573124,
-0.038964591920375824,
0.01103160809725523,
-0.10057222843170166,
0.12633387744426727,
0.06271456182003021,
0.2277204394340515,
-0.16659857332706451,
0.13339772820472717,
-0.24320991337299347,
0.155815988779068,
0.045429833233356476,
0.08215929567813873,
-0.10091078281402588,
0.06778134405612946,
-0.26332107186317444,
-0.014528871513903141,
-0.2512408494949341,
-0.000027635493097477593,
-0.1395813226699829,
0.12564121186733246,
-0.23551496863365173,
0.01910005323588848,
-0.058087632060050964,
0.24930064380168915,
-0.022903207689523697,
0.1432068794965744,
0.02241412177681923,
0.07393529266119003,
0.019366789609193802,
-0.028294002637267113,
0.15133602917194366,
0.13723580539226532,
-0.028042776510119438,
-0.21517667174339294,
-0.16199718415737152,
0.23255911469459534,
-0.06274114549160004,
-0.10467442125082016,
-0.027624081820249557,
-0.29721757769584656,
-0.1244024783372879,
0.0533410981297493,
0.023673512041568756,
-0.10937341302633286,
-0.15236449241638184,
0.3205730617046356,
-0.07779769599437714,
0.007949472405016422,
0.0946897640824318,
0.18657316267490387,
-0.12463998794555664,
0.1549760401248932,
0.02477032132446766,
0.06919784098863602,
-0.04013557359576225,
-0.13205017149448395,
0.01165279932320118,
-0.03340257704257965,
0.10728490352630615,
-0.020738311111927032,
-0.3347122073173523,
-0.22411197423934937,
-0.08115881681442261,
0.07805974781513214,
-0.022716857492923737,
-0.04993406683206558,
-0.12364576756954193,
0.1639697551727295,
-0.05129831284284592,
-0.06086970493197441,
0.15869346261024475,
0.042728688567876816,
-0.021823136135935783,
0.015397809445858002,
0.07069253921508789,
0.03367910906672478,
-0.10012233257293701,
0.1025811955332756,
-0.07133238762617111,
-0.07353329658508301,
0.05414675176143646,
0.03707308694720268,
0.024646006524562836,
-0.23127757012844086,
-0.10640212893486023,
0.11693086475133896,
0.06210644543170929,
-0.0792640894651413,
0.04127776622772217,
-0.02045293338596821,
0.10090959072113037,
0.09502001851797104,
-0.07908481359481812,
0.05317160487174988,
-0.05667397379875183,
-0.3268495798110962,
0.0059843785129487514,
-0.08738631755113602,
0.2594912052154541,
-0.11387216299772263,
-0.039865635335445404,
-0.030140578746795654,
0.0498042069375515,
-0.08100362122058868,
0.04836142063140869,
-0.04789210855960846,
0.058501578867435455,
0.07924190163612366,
-0.11033549904823303,
0.09804272651672363,
-0.15087755024433136,
0.04434480890631676,
0.053355712443590164,
0.0012994121061637998,
0.021937832236289978,
0.07244176417589188,
-0.07517930120229721,
-0.20478004217147827,
-0.21643775701522827,
-0.01895746774971485,
-0.042189158499240875,
0.17671819031238556,
0.11694777011871338,
0.16765223443508148,
0.10785137116909027,
0.16800113022327423,
0.15838442742824554,
0.27091604471206665,
-0.1494627445936203,
-0.06287475675344467,
0.058398038148880005,
0.04073664918541908,
-0.24776317179203033,
0.1723141372203827,
0.08406433463096619,
-0.11531180143356323,
0.00627355370670557,
-0.03005153313279152,
0.238686203956604,
0.011532509699463844,
0.04022173583507538,
0.027334511280059814,
0.061985667794942856,
0.015702053904533386,
-0.07923288643360138,
0.14593414962291718,
0.025778982788324356,
-0.057929378002882004,
0.18585604429244995,
-0.0636436715722084,
-0.06039575859904289,
-0.09844498336315155,
0.004656546283513308,
0.0605977401137352,
0.1302832067012787,
0.04178692772984505,
0.14739097654819489,
-0.17373251914978027,
-0.02152584120631218,
0.05632208287715912,
0.06967639923095703,
0.14750586450099945,
0.04959205538034439,
-0.30021876096725464,
-0.08743198215961456,
-0.16024938225746155,
-0.0038258193526417017,
0.22162529826164246,
0.13912063837051392,
-0.105006642639637,
0.19220104813575745,
0.2657727003097534,
-0.13034264743328094,
-0.036620501428842545,
-0.024384232237935066,
0.11205346137285233,
-0.18453717231750488,
-0.018418211489915848,
0.07647310942411423,
-0.10352078825235367,
-0.08939903974533081,
-0.0893927589058876,
-0.13209909200668335,
0.07427249848842621,
0.054836805909872055,
-0.010600244626402855,
-0.015562266111373901,
0.06892189383506775,
-0.023050274699926376,
-0.0037220411468297243,
0.008460872806608677,
-0.03599907085299492,
0.21408610045909882,
-0.316067099571228,
0.0982310026884079,
-0.16309133172035217,
-0.06146867200732231,
0.11874321103096008,
-0.15018993616104126,
0.10062990337610245,
0.18461792171001434,
-0.013222585432231426,
0.176092267036438,
0.02175440639257431,
-0.17314936220645905,
-0.05655967816710472,
0.0756821557879448,
-0.29025277495384216,
-0.059535253793001175,
-0.002654601586982608,
-0.20333343744277954,
0.009610137902200222,
-0.07413730025291443,
0.0028727359604090452,
0.12535938620567322,
-0.21688631176948547,
0.003365706652402878,
-0.00024330787709914148,
0.1636047512292862,
0.10802097618579865,
0.04138191044330597,
-0.17866158485412598,
0.03586818277835846,
0.12551067769527435,
0.0031736213713884354,
0.05678994208574295,
-0.03850112110376358,
-0.011073170229792595,
-0.0528845377266407,
-0.07301389425992966,
0.07831798493862152,
-0.0447956882417202,
0.04031256586313248,
0.01168198324739933,
0.025943215936422348,
-0.402145117521286,
-0.2186199128627777,
0.03261808305978775,
-0.02404932677745819,
0.058622557669878006,
0.02373942732810974,
-0.0806444063782692,
0.13453678786754608,
0.04945261403918266,
0.19089558720588684,
-0.17357192933559418,
-0.03876175731420517,
-0.30900201201438904,
-0.006205925717949867,
-0.05540762096643448,
-0.15775470435619354,
-0.1473596692085266,
0.15553538501262665,
-0.0013885468943044543,
0.14391110837459564,
-0.11079664528369904,
-0.032236259430646896,
0.07647192478179932,
0.048822421580553055,
0.03752085939049721,
0.06311866641044617,
-0.1813933253288269,
0.0842103585600853,
-0.02202650159597397,
0.12083253264427185,
0.15770281851291656,
-0.1434890776872635,
-0.02245282009243965,
0.07519178092479706,
-0.1995450258255005,
0.04936019703745842,
0.03031403012573719,
0.16129577159881592,
-0.07933714985847473,
0.0940195843577385,
0.10782027989625931,
0.22383685410022736,
0.011169513687491417,
-0.0035510307643562555,
-0.08140973001718521,
-0.05479331314563751,
0.11372482031583786,
-0.06345528364181519,
0.08292529731988907,
-0.1509529948234558,
-0.2254941612482071,
0.021441608667373657,
0.11838440597057343,
-0.05848845839500427,
0.047665249556303024,
0.26179295778274536,
-0.05590921267867088,
-0.15570446848869324,
-0.3177499771118164,
0.013968895189464092,
0.001014042878523469,
0.03858199715614319,
0.005642956122756004,
0.13617844879627228,
0.22357706725597382,
0.3252171576023102,
0.14209409058094025,
0.07694365084171295,
0.14140160381793976,
-0.003041540738195181,
-0.15371811389923096,
-0.015840981155633926,
-0.1290576159954071,
-0.024423468858003616,
0.004753317683935165,
0.09001336991786957,
0.05083087831735611,
0.038397543132305145,
-0.07770516723394394,
-0.03501436486840248,
0.22593900561332703,
0.056526340544223785,
0.16060049831867218,
0.0025768382474780083,
-0.12924478948116302,
0.17432384192943573,
0.1159052848815918,
-0.42039862275123596,
-0.07630805671215057,
-0.026203004643321037,
-0.16663123667240143,
-0.04891831427812576,
-0.05052255839109421,
-0.04419735074043274,
0.10400666296482086,
-0.22162257134914398,
-0.013845960609614849,
-0.053787730634212494,
-0.025960229337215424,
-0.11571162194013596,
0.3592681288719177,
0.030491892248392105,
0.06629190593957901,
0.10281224548816681,
0.015684397891163826,
0.06037870794534683,
-0.18233072757720947,
0.054361745715141296,
0.12407582253217697,
-0.036970023065805435,
-0.012182016856968403,
-0.11623834818601608,
-0.02294241264462471,
0.11612705141305923,
0.12729470431804657,
-0.024867672473192215,
0.05423973128199577,
0.2263709306716919,
0.09169051051139832,
0.12938977777957916,
0.051066070795059204,
0.14708910882472992,
0.028582826256752014,
0.04686245322227478,
-0.26532962918281555,
-0.25171756744384766,
0.028891772031784058,
-0.026058336719870567,
0.05607631057500839,
-0.10099820047616959,
0.11149812489748001,
0.1836199015378952,
-0.09964358806610107,
0.038884419947862625,
0.17254957556724548,
-0.20409531891345978,
0.02667255327105522,
0.05177481472492218,
0.023169444873929024,
0.053132228553295135,
0.07336466014385223,
0.18049907684326172,
0.009239435195922852,
0.06461410224437714,
-0.06832845509052277,
0.07446004450321198,
-0.11497896909713745,
-0.05856569856405258,
0.08580127358436584,
0.22000274062156677,
0.038788214325904846,
0.0366145521402359,
0.01719949208199978,
0.13187238574028015,
-0.1068519577383995,
0.0717717781662941,
-0.020692354068160057,
-0.01726333610713482,
-0.00842034351080656,
-0.21516916155815125,
-0.12269819527864456,
-0.0622701495885849,
-0.04298756271600723,
0.009728508070111275,
0.012445892207324505,
0.14662383496761322,
-0.02500120922923088,
0.11547710746526718,
0.07376940548419952,
-0.05384426936507225,
-0.12738321721553802,
0.020914437249302864,
0.0767960324883461,
-0.00840473361313343,
-0.047570981085300446,
-0.02839810401201248,
0.13293799757957458,
-0.030510421842336655,
-0.1957784742116928,
-0.03840427100658417,
0.0023295104037970304,
0.13904406130313873,
0.048191316425800323,
-0.15426898002624512,
0.0651216134428978,
0.029973547905683517,
0.17627853155136108,
0.05130983516573906,
-0.1966117024421692,
0.004647174384444952,
-0.12697970867156982,
0.20773902535438538,
0.1381281465291977,
0.13355641067028046,
0.01533811166882515,
0.13445504009723663,
0.07631105184555054,
-0.02691461145877838,
-0.1655808687210083,
-0.09866786748170853,
0.0389215461909771,
0.009153160266578197,
-0.0443122535943985,
-0.15441712737083435,
0.044755373150110245,
-0.11510911583900452,
-0.1108250543475151,
0.133726105093956,
0.1908188760280609,
-0.08564802259206772,
-0.20822714269161224,
0.004335503093898296,
-0.1678544133901596,
-0.03389723598957062,
0.33433645963668823,
0.021012237295508385,
0.11438681930303574,
-0.009419639594852924,
-0.10095276683568954,
-0.02230185829102993,
-0.12427433580160141,
0.026961160823702812,
0.03760074824094772,
-0.06676869094371796,
0.0019317485857754946,
0.024007167667150497,
-0.00035110232420265675,
-0.08591348677873611,
-0.005316138733178377,
-0.08708137273788452,
-0.15834015607833862,
0.24852512776851654,
-0.15340778231620789,
-0.1517760455608368,
-0.013412347063422203,
-0.15668858587741852,
-0.16025185585021973,
0.15663209557533264,
0.06728348881006241,
0.32349851727485657,
-0.06830249726772308,
-0.26925718784332275,
-0.09374383091926575,
-0.14437322318553925,
-0.07625916600227356,
-0.03798505291342735,
-0.19527791440486908,
0.004923139698803425,
0.05398865044116974,
0.162499338388443,
-0.10670331120491028,
-0.012431652285158634,
-0.13294260203838348,
-0.24403178691864014,
0.053161103278398514,
0.16564202308654785,
-0.10265584290027618,
0.13207750022411346,
-0.08016332983970642,
-0.014243130572140217,
0.02402784675359726,
-0.16984939575195312,
-0.0007086442201398313,
0.06539704650640488,
0.03565317764878273,
-0.16477973759174347,
0.07442553341388702,
-0.0802161768078804,
0.1605430245399475,
0.036364175379276276,
-0.006570042110979557,
-0.2039557844400406,
-0.03453820198774338,
0.21986256539821625,
0.13664259016513824,
-0.18172815442085266,
0.06267493218183517,
-0.058569882065057755,
-0.19723650813102722,
0.03327171131968498,
0.1918535679578781,
0.015136690810322762,
0.0675482526421547,
-0.18035174906253815,
-0.2980707287788391,
-0.1781422346830368,
-0.07280008494853973,
-0.06263498961925507,
0.027917644008994102,
-0.0725347027182579,
-0.05036891996860504,
0.0704505518078804,
0.0772828459739685,
0.12882646918296814,
0.17117275297641754,
0.03364237770438194,
0.004016908351331949,
-0.151153102517128,
0.06527874618768692,
-0.028881948441267014,
-0.11882562935352325,
-0.20857247710227966,
-0.14674249291419983,
0.023078713566064835,
-0.09440100193023682,
0.00971407163888216,
-0.08774637430906296,
0.06238579750061035,
-0.16537857055664062,
0.008255225606262684,
0.040275637060403824,
0.22596120834350586,
0.04499724507331848,
-0.1558866947889328,
0.11725366115570068,
0.02280854433774948,
-0.07642760872840881,
-0.010213091969490051,
0.28272953629493713,
-0.003247711807489395,
-0.11442317813634872,
0.09400209039449692,
-0.17504575848579407,
-0.33499595522880554,
-0.08963571488857269,
0.06691130995750427,
0.1061573326587677,
-0.1281108409166336,
0.1550220400094986,
-0.11509165167808533,
0.07816322147846222,
0.11439080536365509,
0.040973834693431854,
0.01865200139582157,
0.16950048506259918,
-0.13799721002578735,
-0.025959204882383347,
-0.0688251256942749,
0.06468980759382248,
0.1140107586979866,
0.0011660488089546561,
-0.15083704888820648,
0.22278530895709991,
0.020657986402511597,
-0.03413862735033035,
-0.05043773353099823,
-0.015630459412932396,
0.1582716554403305,
-0.02253766357898712,
-0.12896452844142914,
0.0534038208425045,
-0.12452235817909241,
0.12178286164999008,
-0.28629374504089355,
0.0036434954963624477,
-0.08257871121168137,
-0.05695338919758797,
0.015560123138129711,
0.07104116678237915,
-0.12641826272010803,
0.12221864610910416,
0.13134366273880005,
0.2364075779914856,
0.01473546214401722,
0.21511606872081757,
-0.18614257872104645,
0.2935979962348938,
-0.009052329696714878,
0.0789058655500412,
-0.17350471019744873,
-0.10382326692342758,
0.1707596480846405,
-0.12195014953613281,
-0.0774855986237526,
0.07176095992326736,
-0.09998690336942673,
0.03569779917597771,
0.2510262131690979,
-0.0176930520683527,
-0.04627169668674469,
-0.058778196573257446,
0.14759361743927002,
-0.014172776602208614,
-0.005003484431654215,
-0.09439235180616379,
0.015767207369208336,
-0.16225576400756836,
0.14479130506515503,
-0.07737009227275848,
0.02249997854232788,
-0.2047003209590912,
0.07517391443252563,
-0.09359782189130783,
-0.1647828370332718,
0.006658385973423719,
0.0031801986042410135,
-0.050883207470178604,
0.09947432577610016,
-0.15351824462413788,
0.2477547973394394,
0.28376269340515137,
-0.14913120865821838,
0.20052553713321686,
-0.03793460130691528,
0.22158193588256836,
-0.21469824016094208,
-0.10759153217077255,
0.018674472346901894,
0.019930025562644005,
0.010874011553823948,
0.010197666473686695,
0.11752492189407349,
0.11972693353891373,
-0.07088200747966766,
0.03172629326581955,
-0.2170134037733078,
-0.1623983234167099,
0.00856727734208107,
0.10169829428195953,
0.04613867402076721,
0.07244822382926941,
0.1047760546207428,
-0.07750746607780457,
0.2422316074371338,
-0.07261952757835388,
0.19341281056404114,
-0.06743938475847244,
-0.2766585946083069,
-0.16329488158226013,
0.04766373708844185,
-0.1324538290500641,
0.12806233763694763,
-0.12141873687505722,
-0.02342807874083519,
0.18927088379859924,
-0.05662816762924194,
0.06567604839801788,
-0.04908454045653343,
0.023168496787548065,
0.19943156838417053,
0.012699446640908718,
0.034715957939624786,
0.2258138358592987,
-0.05924529582262039,
-0.1822737753391266,
-0.1593571901321411,
-0.1507968157529831,
-0.09788887202739716,
0.05407949537038803,
0.09189200401306152,
-0.08487370610237122,
-0.1405261754989624,
0.22068725526332855,
-0.14690232276916504,
0.04615293815732002,
-0.024896739050745964,
-0.11946636438369751,
-0.15170229971408844,
0.050088655203580856,
-0.0037403639871627092,
-0.16009658575057983,
0.172178715467453,
-0.03247344493865967,
0.19788631796836853,
-0.1602519303560257,
-0.1436876356601715,
0.04127511382102966,
-0.017811667174100876,
0.01858401484787464,
-0.18388088047504425,
0.0034036594443023205,
0.034607525914907455,
-0.2037537693977356,
0.11603234708309174,
0.18131625652313232,
-0.002692538546398282,
-0.06104704365134239,
-0.017789388075470924,
-0.3242143392562866,
0.04380475729703903,
-0.08910476416349411,
0.205825537443161,
0.011899573728442192,
0.08846813440322876,
-0.03303305804729462,
-0.31720566749572754,
-0.07437893003225327,
0.049389392137527466,
0.05629029497504234,
-0.14901427924633026,
0.044148147106170654,
0.11909183114767075,
-0.09107227623462677,
-0.18908847868442535,
-0.08209703117609024,
-0.1193426176905632,
0.2347673773765564,
0.1840999871492386,
-0.05336450785398483,
-0.010912952944636345,
-0.04420705512166023,
-0.040789440274238586,
-0.024658551439642906,
-0.13975371420383453,
0.08361931890249252,
-0.10701041668653488,
-0.05403735861182213,
0.005324007011950016,
-0.031829919666051865,
0.08878486603498459,
-0.19708406925201416,
0.26184961199760437,
0.03149115666747093,
0.06564472615718842
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. equence analysis 4Gene-targeted deletion/duplication analysis 5PCCA50%78%18% 6PCCB50%97%3% 71. See Table A. Genes and Databases for chromosome locus and protein.2. See Molecular Genetics for information on allelic variants detected in this gene.3. Kraus et al reported no identifiable pathogenic variants in 7% (4/54) and one identifiable variant in 4% (2/54) of individuals with propionic acidemia. Some of the variants may have escaped detection by existing sequencing methods, but could have been detected by copy number analysis . Desviat et al reported that only 1.5% of individuals with PCCA-related PA could not be characterized molecularly, when analyzed using both sequencing and copy number analysis .4. Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Variants may include small intragenic deletions/insertions and missense, nonsense | [
0.014363976195454597,
0.15175072848796844,
0.04309123381972313,
-0.19196811318397522,
0.1516469568014145,
-0.09593883156776428,
0.13861101865768433,
-0.24312210083007812,
-0.017348745837807655,
-0.057331111282110214,
0.07345270365476608,
0.05958651006221771,
-0.049094680696725845,
0.08095923066139221,
-0.24235360324382782,
0.05818602070212364,
0.15826256573200226,
-0.0240086168050766,
-0.053578685969114304,
-0.028774220496416092,
-0.04516918212175369,
-0.14149320125579834,
0.1340709775686264,
0.04574127495288849,
0.18604464828968048,
-0.20932626724243164,
0.133852019906044,
-0.14519529044628143,
0.1478174328804016,
0.05935179069638252,
0.11228183656930923,
-0.03143036365509033,
0.11437442153692245,
-0.2716028392314911,
-0.061960455030202866,
-0.26874980330467224,
-0.042454157024621964,
-0.13760729134082794,
0.13236549496650696,
-0.22555211186408997,
0.004105600528419018,
-0.10065525025129318,
0.2621672749519348,
-0.014265151694417,
0.09169435501098633,
-0.016833366826176643,
0.037156589329242706,
0.03657970204949379,
0.033890098333358765,
0.22284698486328125,
0.06229964643716812,
-0.03546064347028732,
-0.1829119771718979,
-0.11509320139884949,
0.24097199738025665,
-0.06876213848590851,
-0.1202968880534172,
-0.004450623877346516,
-0.3118363320827484,
-0.0891597718000412,
0.11202293634414673,
0.06243253871798515,
-0.12376831471920013,
-0.1270400732755661,
0.2955382466316223,
-0.08665056526660919,
0.036160293966531754,
0.10910169035196304,
0.28340283036231995,
-0.07988119125366211,
0.11060168594121933,
0.05030907690525055,
0.06826162338256836,
-0.0373762883245945,
-0.11262134462594986,
-0.007544436026364565,
0.02406284771859646,
0.06786102056503296,
0.05242139473557472,
-0.2804256081581116,
-0.19785740971565247,
-0.0950169786810875,
0.12780864536762238,
-0.05586428940296173,
-0.058627624064683914,
-0.08915183693170547,
0.13028213381767273,
-0.08980722725391388,
-0.06521347165107727,
0.17494626343250275,
0.07522734254598618,
0.029285306110978127,
0.08114560693502426,
0.13421261310577393,
0.030811233446002007,
-0.07059113681316376,
0.06832894682884216,
-0.011822693049907684,
-0.04287096858024597,
0.03810720145702362,
0.0977688804268837,
-0.023322351276874542,
-0.17624662816524506,
-0.11392028629779816,
0.1370500773191452,
0.04371534660458565,
-0.02317839488387108,
0.040622372180223465,
-0.06517189741134644,
0.08846859633922577,
0.009741789661347866,
-0.05516211315989494,
0.04470484331250191,
-0.08210460096597672,
-0.2483086884021759,
-0.031435176730155945,
-0.058639612048864365,
0.27080589532852173,
-0.11434275656938553,
-0.07551449537277222,
0.08865925669670105,
0.07916213572025299,
-0.07109036296606064,
0.05032235011458397,
0.026067495346069336,
0.023753182962536812,
0.0593387596309185,
-0.1027836948633194,
0.10665035247802734,
-0.08285774290561676,
0.07448621094226837,
0.09573563188314438,
-0.001564495381899178,
-0.021460428833961487,
0.023051857948303223,
-0.11129798740148544,
-0.24653872847557068,
-0.18588583171367645,
-0.0410996675491333,
-0.060987286269664764,
0.1444350630044937,
0.06985700130462646,
0.13732536137104034,
0.09939771145582199,
0.2078281044960022,
0.06352315098047256,
0.27365636825561523,
-0.13925281167030334,
-0.08980816602706909,
0.012307907454669476,
-0.02315020188689232,
-0.2227361798286438,
0.17796170711517334,
0.05065656080842018,
-0.12469072639942169,
-0.03741076961159706,
-0.03814651444554329,
0.20862886309623718,
-0.02194543182849884,
0.04489140212535858,
-0.03469539433717728,
0.10156100243330002,
0.07154218852519989,
-0.08626239746809006,
0.1072966679930687,
0.05127370357513428,
-0.036564454436302185,
0.1394646167755127,
-0.08541711419820786,
-0.07595393061637878,
-0.0883089154958725,
0.05459616705775261,
0.03256167843937874,
0.16422723233699799,
0.06367772817611694,
0.14972008764743805,
-0.1369827687740326,
-0.001544108847156167,
0.024707138538360596,
-0.018748031929135323,
0.119159035384655,
-0.005436116363853216,
-0.277294784784317,
-0.1792503148317337,
-0.15663985908031464,
0.02369440719485283,
0.19474174082279205,
0.18049368262290955,
-0.10308010876178741,
0.1710338294506073,
0.1993369162082672,
-0.0927741751074791,
-0.08770323544740677,
-0.07943719625473022,
0.05495969206094742,
-0.19992735981941223,
0.035586126148700714,
0.03155576437711716,
-0.16516800224781036,
-0.0866611897945404,
-0.10524854809045792,
-0.0902235209941864,
-0.010834219865500927,
-0.029751703143119812,
-0.08396471291780472,
-0.0013053050497546792,
0.057114023715257645,
-0.014409146271646023,
-0.043984655290842056,
0.05602262169122696,
-0.031162159517407417,
0.11458415538072586,
-0.2604311406612396,
0.03484318032860756,
-0.0849945917725563,
-0.1025824248790741,
0.15144963562488556,
-0.12113781273365021,
0.10195797681808472,
0.16177572309970856,
0.08209089934825897,
0.16043119132518768,
0.06056990846991539,
-0.20903877913951874,
-0.051252592355012894,
0.06586919724941254,
-0.22187186777591705,
-0.04008030891418457,
-0.07134518772363663,
-0.15909647941589355,
-0.03689170628786087,
-0.13489606976509094,
-0.053191523998975754,
0.10889118164777756,
-0.22172416746616364,
-0.044414978474378586,
0.05576971173286438,
0.09260949492454529,
0.06794262677431107,
0.0754951536655426,
-0.13536331057548523,
0.06128517910838127,
0.07637859880924225,
0.049467530101537704,
0.04651306942105293,
-0.09838206321001053,
0.005167179740965366,
-0.02284139394760132,
-0.13395293056964874,
0.1093263030052185,
-0.0844370573759079,
0.10046525299549103,
0.11297525465488434,
-0.057085514068603516,
-0.33125853538513184,
-0.13884681463241577,
0.04240145534276962,
0.02868647500872612,
-0.015592680312693119,
0.053545571863651276,
-0.055727243423461914,
0.14919815957546234,
-0.011923415586352348,
0.15917043387889862,
-0.16249409317970276,
-0.03367917239665985,
-0.20216713845729828,
-0.05277558043599129,
-0.09372729063034058,
-0.18133744597434998,
-0.20673255622386932,
0.13931404054164886,
0.0006802853313274682,
0.08001957088708878,
-0.09266375750303268,
0.024695809930562973,
0.06433292478322983,
0.03646339103579521,
0.10525524616241455,
0.10107702016830444,
-0.1422092765569687,
0.054637763649225235,
-0.03281863406300545,
0.13134300708770752,
0.19966670870780945,
-0.03566041588783264,
-0.012331412173807621,
0.09776953607797623,
-0.1450706422328949,
0.08835287392139435,
0.02034679800271988,
0.1882498413324356,
-0.05166735127568245,
0.08556970208883286,
0.012158670462667942,
0.21955926716327667,
0.002769708866253495,
-0.009943799115717411,
-0.08841953426599503,
-0.03881844878196716,
0.08313830196857452,
-0.015429741702973843,
0.06264494359493256,
-0.13594187796115875,
-0.1957147866487503,
0.007498304359614849,
0.1322433352470398,
0.0005909986793994904,
0.0443737655878067,
0.14630737900733948,
-0.1255725771188736,
-0.15878978371620178,
-0.2715279161930084,
0.0190933495759964,
-0.03219220042228699,
0.07267389446496964,
-0.025202305987477303,
0.11476610600948334,
0.156339630484581,
0.28265419602394104,
0.10563002526760101,
0.11655158549547195,
0.13731232285499573,
0.0678495317697525,
-0.12556028366088867,
0.015560382977128029,
-0.26577848196029663,
0.029812704771757126,
-0.07072325795888901,
0.12033724039793015,
0.10018552839756012,
0.004920087289065123,
-0.0751529186964035,
-0.06285831332206726,
0.15391378104686737,
0.03586231544613838,
0.19727660715579987,
0.004808033816516399,
-0.06746302545070648,
0.143561452627182,
0.05753668025135994,
-0.42217570543289185,
-0.04176297411322594,
-0.012337896972894669,
-0.13361261785030365,
-0.007061369251459837,
-0.06826962530612946,
-0.10657098889350891,
0.0721319243311882,
-0.1623680293560028,
-0.05436023697257042,
-0.12593261897563934,
-0.06721188873052597,
-0.07418058067560196,
0.28545334935188293,
0.003802261082455516,
0.029301252216100693,
0.16868507862091064,
0.0014448304427787662,
0.07681389898061752,
-0.15091542899608612,
-0.013355996459722519,
0.03810812905430794,
-0.027735037729144096,
0.03366747498512268,
-0.21009112894535065,
-0.002086919965222478,
0.1172894835472107,
0.14891202747821808,
0.03567102923989296,
0.07834474742412567,
0.23564457893371582,
0.05447770282626152,
0.09185170382261276,
-0.020038504153490067,
0.1478421986103058,
-0.008416532538831234,
0.019034383818507195,
-0.181354820728302,
-0.12467006593942642,
0.07435477524995804,
-0.002547815442085266,
0.07365348935127258,
-0.09478896111249924,
0.02240162156522274,
0.13014842569828033,
-0.07372459769248962,
0.024844996631145477,
0.20375730097293854,
-0.21286526322364807,
0.01967979222536087,
-0.02895965427160263,
0.05344361066818237,
0.07413100451231003,
0.12376932799816132,
0.2074250876903534,
-0.045589275658130646,
0.09043581038713455,
-0.0565694235265255,
0.0698779746890068,
-0.17271195352077484,
-0.10941677540540695,
0.08098489791154861,
0.19153191149234772,
0.015653055161237717,
0.007444660644978285,
-0.017117006704211235,
0.15536648035049438,
-0.09578104317188263,
0.09515371173620224,
-0.036418985575437546,
0.0005313794245012105,
-0.022652925923466682,
-0.14936433732509613,
-0.10122902691364288,
-0.03926217183470726,
-0.0070964316837489605,
0.0035870964638888836,
0.027575869113206863,
0.07423452287912369,
-0.04321111738681793,
0.10201553255319595,
0.08206328004598618,
0.02600564807653427,
-0.09860514849424362,
-0.011191589757800102,
0.009442469105124474,
0.09344208240509033,
0.0017096697119995952,
0.004900489933788776,
0.1160876676440239,
-0.016347605735063553,
-0.15306143462657928,
-0.042874887585639954,
0.010693988762795925,
0.13048218190670013,
0.1125069186091423,
-0.15106599032878876,
0.07944554090499878,
0.020809683948755264,
0.15603727102279663,
0.05795136094093323,
-0.17962132394313812,
-0.039224229753017426,
-0.07512185722589493,
0.17312556505203247,
0.19336208701133728,
0.059407953172922134,
-0.03233616054058075,
0.049975261092185974,
0.04391838610172272,
-0.07521146535873413,
-0.1404319405555725,
-0.11893244832754135,
0.06429556012153625,
0.05884870886802673,
-0.010675845667719841,
-0.12761256098747253,
0.0012845081510022283,
-0.12040664255619049,
-0.12692244350910187,
0.15225541591644287,
0.15815496444702148,
-0.061600420624017715,
-0.14431358873844147,
-0.0026581669226288795,
-0.06153498589992523,
-0.08459518104791641,
0.2875978648662567,
0.011560761369764805,
0.19695933163166046,
-0.03519412875175476,
-0.12363521009683609,
0.019874168559908867,
-0.12843576073646545,
-0.0481019988656044,
0.04013776034116745,
-0.050918370485305786,
-0.0042598312720656395,
0.0441015250980854,
0.01262163370847702,
-0.11808758974075317,
-0.03650197759270668,
-0.13809382915496826,
-0.09984711557626724,
0.26407355070114136,
-0.1956777423620224,
-0.14491041004657745,
0.05987635254859924,
-0.09789228439331055,
-0.12767457962036133,
0.14198780059814453,
0.08034710586071014,
0.3008384704589844,
-0.0959610566496849,
-0.20839475095272064,
-0.043487198650836945,
-0.14583143591880798,
-0.09291987866163254,
-0.016441117972135544,
-0.16718755662441254,
0.08407621085643768,
0.03438302129507065,
0.06944917142391205,
-0.14346712827682495,
-0.06755661219358444,
-0.05992638319730759,
-0.27091094851493835,
0.034284237772226334,
0.15735739469528198,
-0.1500563621520996,
0.06931916624307632,
-0.030450794845819473,
-0.05831340327858925,
0.017792781814932823,
-0.18092721700668335,
-0.009725612588226795,
0.0295623280107975,
0.06302673369646072,
-0.14901313185691833,
0.06379366666078568,
-0.11314608156681061,
0.19366268813610077,
0.041874613612890244,
-0.012738815508782864,
-0.16433726251125336,
-0.06158864125609398,
0.21061478555202484,
0.09123656153678894,
-0.1488385647535324,
0.012479865923523903,
-0.06340458244085312,
-0.18093031644821167,
0.021295513957738876,
0.10918131470680237,
0.05594806373119354,
0.025324806571006775,
-0.1675192415714264,
-0.2923012673854828,
-0.14455382525920868,
-0.027003394439816475,
-0.08951901644468307,
-0.019979042932391167,
-0.005220091436058283,
-0.05564286559820175,
0.00946936197578907,
0.03694039583206177,
0.1723562777042389,
0.2291528582572937,
0.12838692963123322,
0.011243481189012527,
-0.15930157899856567,
0.0066214874386787415,
-0.04452737793326378,
-0.09637775272130966,
-0.15813946723937988,
-0.03643764182925224,
-0.0360964834690094,
-0.10630712658166885,
0.022839374840259552,
-0.09220480918884277,
0.05543225258588791,
-0.14453047513961792,
-0.007548394612967968,
0.06191052123904228,
0.21524396538734436,
0.04887618497014046,
-0.0840546116232872,
0.153102844953537,
-0.031688012182712555,
-0.08397014439105988,
-0.05527206510305405,
0.2675773501396179,
0.018917346373200417,
-0.13847054541110992,
0.12937816977500916,
-0.19161675870418549,
-0.2646172344684601,
-0.10615064948797226,
0.004426494240760803,
0.05776761844754219,
-0.11243095248937607,
0.14944258332252502,
-0.1557588428258896,
0.05723552033305168,
0.14903812110424042,
-0.026986993849277496,
-0.0073455702513456345,
0.15140089392662048,
-0.08162399381399155,
0.0006393982330337167,
-0.05305890366435051,
0.06912732869386673,
0.02384796552360058,
0.0187158714979887,
-0.08100007474422455,
0.19873963296413422,
-0.011299810372292995,
-0.10751831531524658,
-0.07123098522424698,
-0.01830647885799408,
0.14899832010269165,
-0.06156633049249649,
-0.12886834144592285,
0.023599207401275635,
-0.08087707310914993,
0.08535610139369965,
-0.29042384028434753,
0.00835664663463831,
-0.17649835348129272,
-0.07789086550474167,
-0.05502714216709137,
0.09233798086643219,
-0.10149071365594864,
0.20317202806472778,
0.10227381438016891,
0.2501589059829712,
0.000735810783226043,
0.2784954607486725,
-0.14013825356960297,
0.28200817108154297,
-0.002226367127150297,
0.0680103600025177,
-0.10499966144561768,
-0.08875921368598938,
0.15475817024707794,
-0.07466784119606018,
-0.03410887345671654,
0.08882428705692291,
-0.1758582890033722,
-0.013147899881005287,
0.19882123172283173,
0.08370234072208405,
-0.007336325943470001,
-0.04301154613494873,
0.13053828477859497,
-0.04838896915316582,
-0.008406376466155052,
-0.08264245092868805,
0.04011952131986618,
-0.039176423102617264,
0.06575904786586761,
-0.13747185468673706,
0.06531453877687454,
-0.21234048902988434,
0.06122753396630287,
-0.11245567351579666,
-0.18113674223423004,
-0.012178429402410984,
-0.046542391180992126,
-0.047768734395504,
0.17766517400741577,
-0.13590577244758606,
0.239358589053154,
0.2646072506904602,
-0.21170386672019958,
0.13973431289196014,
0.0064052096568048,
0.25863397121429443,
-0.16439884901046753,
-0.12907564640045166,
-0.08919363468885422,
0.007205934729427099,
0.02902209199965,
0.008162258192896843,
0.09525487571954727,
0.008878562599420547,
-0.07531320303678513,
0.07604637742042542,
-0.29375335574150085,
-0.13082318007946014,
-0.03593792766332626,
0.05175066739320755,
-0.0103414012119174,
0.04084334522485733,
0.11877810209989548,
-0.10165416449308395,
0.27139177918434143,
-0.07554125040769577,
0.23135627806186676,
-0.10928317159414291,
-0.2969427704811096,
-0.1512434333562851,
0.0358327217400074,
-0.06714413315057755,
0.09263155609369278,
-0.017891336232423782,
0.07354693859815598,
0.1319097876548767,
-0.03895850107073784,
0.015183495357632637,
-0.07835789024829865,
0.038094282150268555,
0.13853468000888824,
0.01835007034242153,
0.05520104616880417,
0.2664547860622406,
-0.01961090788245201,
-0.25017738342285156,
-0.13346028327941895,
-0.11576652526855469,
-0.10560145974159241,
0.07983950525522232,
0.10337034612894058,
-0.13360871374607086,
-0.12195522338151932,
0.2496665120124817,
-0.12455612421035767,
0.033580608665943146,
-0.13198205828666687,
-0.13401320576667786,
-0.13243244588375092,
0.09720378369092941,
-0.05167507380247116,
-0.14448843896389008,
0.08333215117454529,
-0.041616011410951614,
0.17692838609218597,
-0.09341726452112198,
-0.1660808026790619,
-0.008425168693065643,
-0.04098439961671829,
-0.03687291964888573,
-0.1642220914363861,
0.029513759538531303,
0.09231381118297577,
-0.16760721802711487,
0.20841895043849945,
0.161214679479599,
-0.005774015560746193,
-0.04888417199254036,
0.056185223162174225,
-0.24978007376194,
0.0003620289789978415,
-0.056933607906103134,
0.1344451606273651,
-0.009052419103682041,
0.06554127484560013,
-0.018649594858288765,
-0.25736454129219055,
-0.021496402099728584,
0.03901940584182739,
-0.01241772435605526,
-0.15263672173023224,
0.05166025087237358,
0.09563902020454407,
-0.0906551331281662,
-0.13344645500183105,
-0.04805847629904747,
-0.14891581237316132,
0.28332042694091797,
0.2156781256198883,
-0.05826633423566818,
-0.07537990063428879,
-0.06332696229219437,
-0.01787729747593403,
-0.05065400153398514,
-0.10816075652837753,
0.06611113995313644,
-0.04793087765574455,
-0.04918419197201729,
0.0028822049498558044,
0.031730979681015015,
0.0551103875041008,
-0.1717192381620407,
0.23593878746032715,
-0.017851486802101135,
0.02969636209309101
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. propionic acidemia. Some of the variants may have escaped detection by existing sequencing methods, but could have been detected by copy number analysis . Desviat et al reported that only 1.5% of individuals with PCCA-related PA could not be characterized molecularly, when analyzed using both sequencing and copy number analysis .4. Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Variants may include small intragenic deletions/insertions and missense, nonsense, and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.5. Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and a gene-targeted microarray designed to detect single exon deletions or duplications.6. Exon deletions account for | [
0.041889507323503494,
0.09024794399738312,
0.018309539183974266,
-0.02014518715441227,
0.1095956563949585,
-0.1504843533039093,
0.059995658695697784,
-0.1859922856092453,
-0.0649244412779808,
-0.013820578344166279,
0.26674768328666687,
-0.004655223805457354,
-0.04844682663679123,
-0.03581361845135689,
-0.23094674944877625,
0.013114546425640583,
0.07106273621320724,
-0.0762283131480217,
-0.09325840324163437,
0.0229476448148489,
0.11508291214704514,
-0.1714998185634613,
0.15897662937641144,
0.10989780724048615,
0.22619077563285828,
-0.1678871512413025,
0.18800896406173706,
-0.13923554122447968,
0.03561733663082123,
-0.06396157294511795,
0.2286202609539032,
-0.024878423660993576,
0.17668938636779785,
-0.24087651073932648,
0.03009420447051525,
-0.34805426001548767,
-0.07324017584323883,
0.023315275087952614,
0.04718495160341263,
-0.16802994906902313,
0.14737816154956818,
-0.11579041928052902,
0.13372988998889923,
0.04863138124346733,
0.07917552441358566,
-0.08175507932901382,
-0.0229667816311121,
-0.05604082718491554,
-0.00018747827562037855,
0.07947588711977005,
0.07608432322740555,
-0.15268810093402863,
-0.025661390274763107,
-0.07384593784809113,
0.27014386653900146,
-0.0036017464008182287,
-0.12118551880121231,
-0.028864776715636253,
-0.33306699991226196,
-0.10506799072027206,
-0.03188338130712509,
-0.004933257587254047,
-0.17379647493362427,
-0.1957319676876068,
0.287200003862381,
-0.13548754155635834,
-0.022403951734304428,
-0.021420365199446678,
0.2707549035549164,
-0.06592325866222382,
0.12927201390266418,
-0.11855120211839676,
0.052102379500865936,
0.06413187831640244,
-0.053006868809461594,
-0.00010648949682945386,
0.08073561638593674,
0.16530035436153412,
0.1529846042394638,
-0.2991727292537689,
-0.07741477340459824,
-0.15978814661502838,
-0.09620407968759537,
0.07529817521572113,
0.014117838814854622,
-0.20999015867710114,
0.12414809316396713,
-0.10634168237447739,
-0.07646817713975906,
0.008435370400547981,
0.03867897391319275,
-0.04495133459568024,
0.13966961205005646,
0.2874394357204437,
0.045487869530916214,
-0.07538652420043945,
-0.08088658004999161,
0.0953013226389885,
-0.07921204715967178,
0.009784620255231857,
-0.024604950100183487,
0.052513010799884796,
-0.24507680535316467,
-0.1383495032787323,
0.1862112134695053,
0.026346491649746895,
0.009269393049180508,
-0.014999798499047756,
-0.0657147765159607,
0.11464956402778625,
-0.0292203426361084,
-0.14992302656173706,
0.03902458772063255,
-0.0438082329928875,
-0.2652014493942261,
0.0091897277161479,
0.03577163442969322,
0.20123960077762604,
-0.08473549783229828,
-0.04978005215525627,
0.06434392184019089,
0.044964782893657684,
-0.0010771166998893023,
0.2386532574892044,
0.06638802587985992,
-0.022156065329909325,
0.1369081288576126,
0.014203885570168495,
0.15855321288108826,
-0.11895505338907242,
0.15831564366817474,
0.12739211320877075,
-0.1391260176897049,
-0.03715093433856964,
-0.014421829953789711,
-0.17910362780094147,
-0.33633387088775635,
-0.26188766956329346,
0.05359680950641632,
-0.05609993636608124,
0.23963843286037445,
0.09812995791435242,
0.09550610184669495,
0.14945529401302338,
0.2011018544435501,
0.09719666838645935,
0.17941364645957947,
-0.21052345633506775,
-0.08235786855220795,
-0.06214902177453041,
-0.022008322179317474,
-0.0700562596321106,
0.20976518094539642,
-0.05279465392231941,
-0.1388564258813858,
0.009462961927056313,
-0.009755200706422329,
0.17718666791915894,
-0.1605699509382248,
0.0464831106364727,
0.052864767611026764,
-0.028718706220388412,
0.13843278586864471,
-0.15117330849170685,
0.09578912705183029,
0.07960567623376846,
0.07456406205892563,
0.12044145166873932,
-0.00383223919197917,
-0.05923426151275635,
-0.11128538101911545,
-0.005420093424618244,
0.08922425657510757,
0.0002619092701934278,
-0.029019752517342567,
0.08002734929323196,
-0.07193205505609512,
-0.03224673494696617,
-0.03597058728337288,
-0.02785845473408699,
0.07261727750301361,
-0.048143044114112854,
-0.24214358627796173,
-0.11530441045761108,
0.01448522787541151,
-0.12283343076705933,
0.2349601686000824,
0.13057146966457367,
-0.1435425579547882,
0.4223976731300354,
0.14178773760795593,
-0.013208737596869469,
-0.03448856621980667,
-0.09844813495874405,
0.014178205281496048,
-0.25689494609832764,
0.12918877601623535,
0.12251031398773193,
-0.10657630860805511,
0.07026698440313339,
-0.1061820536851883,
0.07718165963888168,
-0.16046717762947083,
0.0722212865948677,
-0.18355123698711395,
-0.044210221618413925,
0.1240188330411911,
0.13176266849040985,
-0.03049156628549099,
0.22698335349559784,
-0.12465925514698029,
0.04985581710934639,
-0.2611581087112427,
0.14094066619873047,
-0.0020742262713611126,
-0.14385338127613068,
0.12839029729366302,
-0.07295215874910355,
0.010220511816442013,
0.24886322021484375,
0.09986596554517746,
0.09184228628873825,
-0.010228031314909458,
-0.2218865007162094,
0.01244316529482603,
-0.015912655740976334,
-0.19712333381175995,
-0.06376650184392929,
-0.03140457719564438,
-0.10046183317899704,
-0.0620516836643219,
-0.027538208290934563,
-0.03785298019647598,
0.13856221735477448,
-0.27445948123931885,
0.03967682272195816,
0.11002249270677567,
0.12216714024543762,
-0.04983849078416824,
0.042016033083200455,
-0.26436012983322144,
-0.0103983785957098,
0.07687727361917496,
0.055185046046972275,
0.03043733537197113,
-0.0472506545484066,
0.08378224074840546,
-0.09765300154685974,
-0.0803065076470375,
0.1845879852771759,
-0.013888535089790821,
-0.036713141947984695,
0.043249957263469696,
0.027410268783569336,
-0.4714771509170532,
-0.11546417325735092,
-0.019624827429652214,
0.12329978495836258,
0.04677017778158188,
0.05951584503054619,
-0.04404444247484207,
0.3000023663043976,
-0.023200402036309242,
0.010828271508216858,
-0.19348038733005524,
0.05699317902326584,
-0.20797042548656464,
-0.04037101939320564,
0.05001441389322281,
-0.145668625831604,
-0.283491849899292,
0.153416246175766,
0.007901355624198914,
0.10084028542041779,
-0.16421259939670563,
0.03618905693292618,
0.13190218806266785,
-0.02756406180560589,
0.14386026561260223,
0.03894411027431488,
0.018213097006082535,
0.055526357144117355,
-0.1243828535079956,
0.07937680184841156,
0.11872579157352448,
-0.08551257103681564,
0.09606731683015823,
0.11029855161905289,
0.10848287492990494,
0.11528999358415604,
0.004862491972744465,
0.19971641898155212,
0.0561433807015419,
-0.03753865137696266,
-0.07143484801054001,
0.04415543004870415,
-0.0015198318287730217,
0.00837402231991291,
-0.040820762515068054,
0.03855763003230095,
-0.02630526013672352,
-0.1543121635913849,
0.009939569048583508,
-0.12263114750385284,
-0.17770007252693176,
0.17952372133731842,
-0.07441425323486328,
0.17305374145507812,
-0.05539178475737572,
0.13934838771820068,
-0.14624379575252533,
-0.11241920292377472,
-0.19135133922100067,
0.09374044090509415,
-0.04276755824685097,
0.10362464934587479,
0.1252782791852951,
0.12207870185375214,
0.05408083647489548,
0.258039653301239,
0.034793782979249954,
0.057568762451410294,
0.2491801679134369,
0.18506471812725067,
-0.1531534045934677,
-0.04366401582956314,
-0.18107768893241882,
0.014088545925915241,
-0.17823946475982666,
0.0348438061773777,
-0.06481969356536865,
0.0475434809923172,
-0.008008857257664204,
-0.06798649579286575,
-0.07272019982337952,
0.1390938013792038,
0.3062882423400879,
-0.03641965240240097,
-0.07245993614196777,
0.060922153294086456,
0.16566377878189087,
-0.46018528938293457,
-0.11438141018152237,
0.14708755910396576,
-0.00977613590657711,
0.0020143252331763506,
-0.006740148179233074,
-0.055604107677936554,
0.13560207188129425,
-0.1775425523519516,
-0.11437109112739563,
-0.11864963918924332,
-0.11756590008735657,
-0.07749200612306595,
0.2724004089832306,
0.10728650540113449,
0.1505235731601715,
-0.02991410531103611,
0.013465477153658867,
0.10412823408842087,
0.0035915838088840246,
0.03346516191959381,
0.04483387619256973,
0.04162139073014259,
-0.09172350913286209,
-0.12918488681316376,
-0.08509286493062973,
0.034739915281534195,
0.041206732392311096,
0.09627770632505417,
0.03997642546892166,
0.3358374834060669,
0.10444700717926025,
-0.035141121596097946,
-0.039090316742658615,
0.11265869438648224,
-0.09023422747850418,
0.030833961442112923,
-0.07892131805419922,
-0.03077271580696106,
0.0855262503027916,
0.2508576810359955,
0.04801434651017189,
-0.041065871715545654,
0.030278421938419342,
0.1480141580104828,
-0.25138524174690247,
0.07871443033218384,
0.2794091999530792,
-0.2594011425971985,
0.00976502988487482,
0.14082098007202148,
0.11177932471036911,
0.16535748541355133,
-0.027266306802630424,
0.1623391956090927,
-0.13088028132915497,
-0.04328230395913124,
-0.07590396702289581,
0.19731995463371277,
-0.1406555026769638,
-0.08117472380399704,
0.12229132652282715,
0.26672473549842834,
0.11031608283519745,
-0.022126566618680954,
-0.03098510205745697,
-0.015012464486062527,
0.013673527166247368,
0.16322405636310577,
-0.044741518795490265,
0.1010160893201828,
-0.12730279564857483,
-0.13130126893520355,
-0.30309414863586426,
-0.0789017453789711,
0.006510013248771429,
0.017349224537611008,
0.09155415743589401,
0.04581824690103531,
-0.0700472891330719,
0.10153965651988983,
0.07343878597021103,
0.036257024854421616,
-0.05170978978276253,
-0.11943704634904861,
-0.027158226817846298,
0.12266555428504944,
0.14663417637348175,
0.053903575986623764,
0.13827769458293915,
0.14442060887813568,
-0.24486587941646576,
-0.013036520220339298,
-0.12354312837123871,
0.01743917167186737,
0.048930574208498,
-0.15503215789794922,
0.37671926617622375,
-0.09024281054735184,
0.1222786009311676,
0.14248299598693848,
-0.2180628925561905,
0.148942768573761,
0.00037600743235088885,
0.0859219953417778,
0.159091055393219,
0.03615299239754677,
-0.01467360183596611,
0.044523146003484726,
0.0029728549998253584,
-0.18796032667160034,
-0.1468294858932495,
-0.17218121886253357,
0.14249365031719208,
0.04107516258955002,
0.02954683266580105,
-0.1046920046210289,
-0.15827995538711548,
-0.1305035501718521,
-0.16242322325706482,
-0.01884344406425953,
0.2369605004787445,
-0.08516644686460495,
-0.0014655606355518103,
-0.01405571959912777,
0.025574030354619026,
0.0317918099462986,
0.2600160539150238,
0.18369720876216888,
0.09385102987289429,
0.0035131333861500025,
-0.09621568769216537,
0.048955969512462616,
-0.10698676854372025,
0.015541697852313519,
0.07548941671848297,
-0.16802100837230682,
-0.01956806518137455,
0.15862657129764557,
-0.08174953609704971,
0.11192293465137482,
-0.018800675868988037,
-0.16847220063209534,
-0.11484977602958679,
0.17944325506687164,
-0.102804996073246,
0.06295003741979599,
-0.018682308495044708,
-0.10423728078603745,
-0.08518538624048233,
0.04623498022556305,
0.10419914871454239,
0.15305855870246887,
-0.11667276918888092,
-0.20206280052661896,
-0.2105809599161148,
-0.01566089689731598,
0.045027218759059906,
0.01912526600062847,
-0.18663956224918365,
-0.006904137320816517,
-0.1418170928955078,
0.027524743229150772,
-0.08120503276586533,
-0.10573816299438477,
0.04727312922477722,
-0.26945024728775024,
0.02174399606883526,
0.11384309083223343,
-0.16686688363552094,
0.0073365215212106705,
-0.06727663427591324,
-0.06913816928863525,
-0.0005080508417449892,
-0.3407249450683594,
0.004656242206692696,
0.006301710847765207,
0.07558689266443253,
-0.228972390294075,
0.09754250198602676,
-0.26873740553855896,
0.16092389822006226,
-0.12063760310411453,
-0.06859645247459412,
-0.26344799995422363,
-0.017881156876683235,
0.24012523889541626,
0.09481079876422882,
-0.15458044409751892,
0.03368782252073288,
-0.09315872937440872,
-0.2348843365907669,
0.02250600978732109,
-0.0336453802883625,
0.14453834295272827,
0.1857737898826599,
-0.14520695805549622,
-0.2614814341068268,
-0.11837431788444519,
0.0732317715883255,
0.07627255469560623,
0.03242442384362221,
0.024398289620876312,
-0.12228359282016754,
-0.02613973058760166,
0.11565324664115906,
0.0997411236166954,
0.3211580514907837,
0.022496847435832024,
0.09504548460245132,
-0.13920904695987701,
-0.06568034738302231,
-0.060566335916519165,
-0.20704035460948944,
0.047842126339673996,
0.08999079465866089,
0.08118101954460144,
0.09590626507997513,
0.06369487941265106,
-0.15826253592967987,
0.009288448840379715,
-0.10470075160264969,
-0.008250655606389046,
0.077677883207798,
0.33650073409080505,
-0.02876635454595089,
0.008978323079645634,
0.027808303013443947,
0.0585339218378067,
-0.13707013428211212,
0.02478477917611599,
0.24166342616081238,
0.26269152760505676,
-0.12908051908016205,
0.09263484925031662,
-0.3341665267944336,
-0.326647013425827,
-0.3243231177330017,
0.06984882056713104,
0.054451122879981995,
-0.3156657814979553,
0.16582751274108887,
-0.2559705376625061,
0.2342844158411026,
0.08745229989290237,
-0.024402763694524765,
0.11350242793560028,
0.16091366112232208,
-0.11728359013795853,
0.0893404632806778,
-0.20391210913658142,
0.021830059587955475,
0.012204649858176708,
-0.0814514309167862,
0.002064321655780077,
0.22942239046096802,
0.045220691710710526,
-0.051084358245134354,
-0.067350834608078,
0.0012481745798140764,
0.24165168404579163,
0.012412291951477528,
-0.0853407233953476,
-0.03114304691553116,
-0.0562414713203907,
0.1131238341331482,
-0.3517778515815735,
0.0612172968685627,
-0.08871839940547943,
-0.057083677500486374,
-0.016852080821990967,
-0.07035361975431442,
-0.17635668814182281,
0.27085939049720764,
-0.04240867495536804,
0.20789609849452972,
0.05842623487114906,
0.23190632462501526,
-0.10636816918849945,
0.41569820046424866,
-0.07359009981155396,
0.2066284418106079,
-0.21013829112052917,
-0.1492917537689209,
0.2552500069141388,
-0.15915802121162415,
0.007592443842440844,
-0.06554493308067322,
-0.1646067500114441,
0.1986021250486374,
0.026886828243732452,
-0.03615393862128258,
0.15887098014354706,
-0.07048555463552475,
0.11417338252067566,
-0.0926075428724289,
-0.02098821848630905,
-0.042674921452999115,
-0.004502827301621437,
-0.011296854354441166,
0.061207838356494904,
0.06500352919101715,
0.1202874407172203,
-0.1613139659166336,
0.08884710818529129,
-0.22032664716243744,
-0.20307804644107819,
0.1249905377626419,
-0.04979921877384186,
0.01651628315448761,
0.22591768205165863,
-0.3206294775009155,
0.21714946627616882,
0.21647338569164276,
-0.1985844075679779,
0.006803926080465317,
-0.05419987812638283,
0.2276054322719574,
-0.20397105813026428,
0.06343647837638855,
-0.09951172769069672,
-0.1191297397017479,
-0.08455542474985123,
0.00751314265653491,
0.14157450199127197,
0.1446206122636795,
-0.14606449007987976,
0.16895435750484467,
-0.31318360567092896,
-0.09755619615316391,
0.035775721073150635,
0.03917524218559265,
-0.0585479699075222,
0.06144535169005394,
0.12542884051799774,
-0.12134342640638351,
0.14084312319755554,
-0.0665980651974678,
0.25195032358169556,
-0.10856065154075623,
-0.3776829242706299,
-0.16469526290893555,
-0.04158502817153931,
-0.04263461381196976,
0.09992806613445282,
0.07452657073736191,
0.16486339271068573,
0.05059964209794998,
-0.18343695998191833,
0.049623358994722366,
0.08795419335365295,
0.04013330861926079,
0.08618060499429703,
-0.06888020038604736,
-0.02631375566124916,
0.4771276116371155,
0.012703205458819866,
-0.19206233322620392,
-0.035544440150260925,
-0.06450843811035156,
-0.039377644658088684,
0.05200538784265518,
0.07601950317621231,
-0.14781680703163147,
-0.04773525148630142,
0.23614823818206787,
-0.22129908204078674,
-0.0034402573946863413,
-0.2949732840061188,
-0.0003334272769279778,
-0.14869804680347443,
0.24527250230312347,
0.05356883257627487,
-0.07937539368867874,
0.05379314720630646,
0.06000572443008423,
0.0278110783547163,
-0.08988131582736969,
-0.22820045053958893,
-0.0034021942410618067,
-0.10375451296567917,
-0.14318309724330902,
-0.23003695905208588,
0.09158626198768616,
0.11628319323062897,
-0.22737789154052734,
0.4494129717350006,
0.09610159695148468,
-0.051733918488025665,
-0.08364590257406235,
0.012292593717575073,
-0.28108862042427063,
0.06062592566013336,
0.05921115726232529,
0.09624932706356049,
-0.077069953083992,
-0.01028319913893938,
-0.05493909493088722,
-0.31477752327919006,
-0.06246555224061012,
-0.16674144566059113,
-0.11448201537132263,
-0.16843700408935547,
-0.0006175391026772559,
0.0158492811024189,
0.007387903053313494,
-0.18052341043949127,
-0.06506160646677017,
-0.06763719022274017,
0.13789072632789612,
0.23446989059448242,
0.03567124158143997,
0.0569281242787838,
-0.01244898047298193,
0.016492025926709175,
-0.10028129070997238,
-0.025815661996603012,
-0.04429507255554199,
0.019287029281258583,
-0.10007645189762115,
-0.13458988070487976,
0.08665592223405838,
0.11719051003456116,
0.052465349435806274,
0.22412289679050446,
-0.06541981548070908,
-0.022200312465429306
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. /insertions and missense, nonsense, and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.5. Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and a gene-targeted microarray designed to detect single exon deletions or duplications.6. Exon deletions account for to ~20% of PCCA disease-causing alleles .7. Three PCCB large-deletion alleles have been described .II. An alternative approach involves the assay of propionyl-CoA carboxylase (PCC) enzyme activity in lymphocytes or cultured skin fibroblasts followed by molecular diagnosis . In individuals with equivocal molecular genetic test results, a combination of enzymatic and molecular diagnostics may be necessary.Clinical CharacteristicsClinical DescriptionPropionic acidemia presents with a wide spectrum of symptoms and age of | [
0.026881353929638863,
0.11555709689855576,
0.009282342158257961,
-0.13812264800071716,
0.19828356802463531,
-0.18557803332805634,
0.06451836228370667,
-0.22780367732048035,
0.006695637013763189,
0.1106966882944107,
0.22391730546951294,
-0.03332469239830971,
-0.059073664247989655,
-0.05087876319885254,
-0.3524407744407654,
0.15401554107666016,
0.12262656539678574,
-0.13423249125480652,
-0.07454149425029755,
-0.08802737295627594,
0.12116672098636627,
-0.08847931772470474,
0.16183629631996155,
-0.0009507930371910334,
0.22648239135742188,
-0.2173663228750229,
0.21145795285701752,
-0.1959492564201355,
0.0751616433262825,
-0.12280916422605515,
0.29656296968460083,
-0.036878447979688644,
0.22575734555721283,
-0.27444735169410706,
-0.08639947324991226,
-0.32408392429351807,
-0.11319126933813095,
-0.01848820224404335,
0.08060641586780548,
-0.16746975481510162,
0.13021120429039001,
-0.1626410037279129,
0.2257118821144104,
0.0006878201384097338,
0.11919378489255905,
-0.052179113030433655,
0.010190486907958984,
-0.056027743965387344,
0.016108311712741852,
0.03769911825656891,
0.16511036455631256,
-0.16269885003566742,
-0.09723597764968872,
-0.1131584420800209,
0.20478856563568115,
-0.013464082963764668,
-0.1890546977519989,
-0.03379232808947563,
-0.3281930685043335,
-0.04673274978995323,
-0.0009617417235858738,
-0.0034882354084402323,
-0.10521029680967331,
-0.1632668673992157,
0.290664404630661,
-0.13792961835861206,
0.0035302184987813234,
0.049341849982738495,
0.3244866728782654,
-0.08178089559078217,
0.08647672086954117,
-0.16269978880882263,
0.05033876746892929,
0.07103137671947479,
-0.012092103250324726,
0.12788832187652588,
-0.025272807106375694,
0.07242053747177124,
0.14361591637134552,
-0.3135283887386322,
-0.07745292782783508,
-0.07734118402004242,
0.013605187647044659,
0.10729891806840897,
-0.048192646354436874,
-0.16671964526176453,
0.20363196730613708,
-0.18930071592330933,
-0.1020960658788681,
0.0312957838177681,
0.08421924710273743,
-0.029100002720952034,
0.17945198714733124,
0.23181654512882233,
0.06881756335496902,
-0.14056837558746338,
0.03275817632675171,
0.10429800301790237,
-0.1766231656074524,
-0.04316346347332001,
-0.04770374298095703,
0.07729709148406982,
-0.3166412115097046,
-0.09862280637025833,
0.07957097142934799,
0.027945542708039284,
-0.08689270913600922,
-0.027526790276169777,
-0.08060818910598755,
0.19684246182441711,
0.05188479647040367,
-0.25605595111846924,
0.0206154678016901,
-0.013798338361084461,
-0.2750875651836395,
0.04998663067817688,
0.011980057694017887,
0.24680952727794647,
-0.07760265469551086,
0.07817846536636353,
-0.002171531319618225,
-0.037609897553920746,
0.09309584647417068,
0.19032828509807587,
-0.06197669729590416,
-0.02975630573928356,
0.0522303432226181,
-0.017785048112273216,
0.19267411530017853,
-0.14153839647769928,
0.19355708360671997,
0.17267747223377228,
-0.1328141987323761,
-0.045948922634124756,
0.04756215959787369,
-0.2308623045682907,
-0.4125590920448303,
-0.2921496629714966,
0.07413912564516068,
-0.12456312030553818,
0.2038610428571701,
0.028919173404574394,
0.07404810190200806,
0.13141784071922302,
0.18347705900669098,
0.10393846780061722,
0.30154159665107727,
-0.09795408695936203,
-0.04314768686890602,
-0.058482661843299866,
0.04891362413764,
-0.11901440471410751,
0.15532442927360535,
-0.03095146454870701,
-0.12580642104148865,
0.08663751929998398,
0.012244535610079765,
0.16418148577213287,
-0.16276651620864868,
0.07109399139881134,
0.13932228088378906,
-0.04902035370469093,
0.07267427444458008,
-0.09019593894481659,
0.0899171456694603,
0.03054334968328476,
0.041722435504198074,
0.15230153501033783,
-0.07510838657617569,
-0.10471657663583755,
-0.09115204960107803,
-0.053096041083335876,
0.1629388928413391,
0.03898944333195686,
0.027805104851722717,
0.22707948088645935,
-0.15069249272346497,
0.019207734614610672,
0.0053425077348947525,
-0.06763087213039398,
0.09758533537387848,
0.032630786299705505,
-0.23840221762657166,
-0.09590163081884384,
0.06149670109152794,
-0.1976286619901657,
0.23123925924301147,
0.13270561397075653,
-0.1248336210846901,
0.3519097864627838,
0.10436233878135681,
-0.05181533470749855,
0.013518687337636948,
-0.0796235129237175,
-0.06156931817531586,
-0.23289848864078522,
0.039849527180194855,
0.06265051662921906,
-0.1726684719324112,
0.15214908123016357,
-0.10146787762641907,
0.05853838101029396,
-0.15047290921211243,
0.07093346863985062,
-0.09008033573627472,
-0.039888519793748856,
0.0248105488717556,
0.07984544336795807,
0.026344185695052147,
0.23932911455631256,
-0.1529032438993454,
0.10665937513113022,
-0.2769180238246918,
0.1630374640226364,
-0.03519582748413086,
-0.13952456414699554,
0.11068632453680038,
-0.10156311094760895,
0.11069536954164505,
0.29701218008995056,
0.2511485815048218,
0.15420372784137726,
-0.026483353227376938,
-0.29313626885414124,
0.06379933655261993,
0.07608939707279205,
-0.2506713569164276,
-0.17433272302150726,
-0.014419765211641788,
-0.16788113117218018,
-0.07057984918355942,
-0.016211383044719696,
-0.10094589740037918,
0.14532527327537537,
-0.14259123802185059,
-0.03191191330552101,
0.04277781397104263,
0.17980806529521942,
-0.05236733332276344,
-0.013739160262048244,
-0.3376651108264923,
0.005555270705372095,
0.031997859477996826,
0.11479616910219193,
-0.026279054582118988,
0.08550819754600525,
0.10199310630559921,
-0.020532263442873955,
-0.09368126094341278,
0.22247572243213654,
0.03694344684481621,
-0.02162938378751278,
-0.07202951610088348,
0.01995009183883667,
-0.4596036672592163,
-0.20832975208759308,
0.04367471858859062,
0.08982597291469574,
0.02361023984849453,
0.030519910156726837,
-0.07985316962003708,
0.24950435757637024,
0.033517949283123016,
-0.03187199681997299,
-0.3074644207954407,
0.08723384886980057,
-0.2134488970041275,
-0.06627238541841507,
0.10803629457950592,
-0.16271674633026123,
-0.2676524817943573,
0.09600381553173065,
0.022678785026073456,
0.12393392622470856,
-0.1747782826423645,
-0.07793569564819336,
0.13864469528198242,
-0.0935317873954773,
0.16069535911083221,
0.2125529944896698,
-0.05312487110495567,
0.07067622244358063,
-0.08327926695346832,
0.10649358481168747,
0.18323810398578644,
-0.09913910180330276,
0.07014063000679016,
0.0204458087682724,
0.07167825102806091,
0.11727133393287659,
-0.01763867400586605,
0.19004514813423157,
0.009264733642339706,
0.01468506921082735,
-0.009710077196359634,
0.010530101135373116,
-0.07564891874790192,
0.02167648635804653,
0.005262043792754412,
0.10659144073724747,
-0.03841036558151245,
-0.04157589003443718,
0.0982922688126564,
-0.20833449065685272,
-0.22871319949626923,
0.1657809019088745,
-0.010668305680155754,
0.07730940729379654,
0.013188505545258522,
0.2288554608821869,
-0.1833096295595169,
-0.017104648053646088,
-0.2737313508987427,
0.10789862275123596,
-0.07362126559019089,
0.0550948865711689,
0.2084345668554306,
0.08938703685998917,
0.16583368182182312,
0.32496973872184753,
-0.09998713433742523,
0.11627181619405746,
0.17770476639270782,
0.16771763563156128,
-0.21243780851364136,
-0.05295801907777786,
-0.18361517786979675,
-0.045359253883361816,
-0.2424890100955963,
0.03170693665742874,
-0.03534030541777611,
0.06778404116630554,
0.054999642074108124,
-0.031620074063539505,
0.07864758372306824,
0.15451432764530182,
0.39849886298179626,
-0.0934525653719902,
-0.08095618337392807,
0.14295350015163422,
0.18423694372177124,
-0.4684094488620758,
-0.1703377515077591,
0.19305504858493805,
-0.11398877203464508,
-0.015181763097643852,
0.004534314852207899,
0.04359350726008415,
0.1615723818540573,
-0.14794602990150452,
-0.024580704048275948,
-0.09250336140394211,
-0.09414655715227127,
-0.11584797501564026,
0.23383891582489014,
0.07196719199419022,
0.16444814205169678,
-0.019102957099676132,
0.02259869873523712,
0.13482923805713654,
-0.060458675026893616,
0.06877065449953079,
0.0876520648598671,
0.1021028608083725,
-0.018965600058436394,
-0.189544677734375,
-0.14813148975372314,
0.027390476316213608,
-0.002176055684685707,
0.09634153544902802,
-0.0005959387635812163,
0.27951017022132874,
0.16095533967018127,
0.0034087449312210083,
-0.05294710397720337,
0.2141600400209427,
-0.1029803603887558,
0.13773687183856964,
-0.20303097367286682,
-0.058268509805202484,
0.109024778008461,
0.27485013008117676,
0.10588105767965317,
-0.06903132051229477,
0.06326306611299515,
0.18371528387069702,
-0.2341248095035553,
0.052809830754995346,
0.2892097234725952,
-0.33237704634666443,
0.07052763551473618,
0.13630977272987366,
0.1518082469701767,
0.10382622480392456,
-0.06998755037784576,
0.1672784835100174,
-0.051346465945243835,
-0.021894235163927078,
-0.08518339693546295,
0.18390095233917236,
-0.18648509681224823,
-0.0837717279791832,
0.05418097600340843,
0.29071950912475586,
0.185712531208992,
0.007559236604720354,
-0.06589346379041672,
0.0009518632432445884,
-0.05886693298816681,
0.071311816573143,
-0.040158893913030624,
-0.003108047880232334,
-0.11878112703561783,
-0.18021385371685028,
-0.312391459941864,
-0.1258048713207245,
0.021677635610103607,
0.005524188280105591,
0.03610439598560333,
-0.06441880017518997,
-0.02501111477613449,
0.13928835093975067,
0.029462888836860657,
0.0031212912872433662,
-0.11994393169879913,
-0.07371995598077774,
-0.05006883665919304,
0.09641017019748688,
0.2189173847436905,
-0.016250327229499817,
0.21593499183654785,
0.09998112171888351,
-0.32822197675704956,
0.012743515893816948,
-0.1797073483467102,
0.06484056264162064,
0.039912622421979904,
-0.07081722468137741,
0.28730136156082153,
-0.144897922873497,
0.15722763538360596,
0.17534783482551575,
-0.19387148320674896,
0.15417788922786713,
0.029679911211133003,
0.21214646100997925,
0.257384717464447,
0.06661702692508698,
0.01000917237251997,
0.06065575033426285,
0.03739040717482567,
-0.1680087447166443,
-0.12990042567253113,
-0.19437386095523834,
0.06939718127250671,
0.07513511180877686,
0.055228084325790405,
-0.15128521621227264,
0.01863100193440914,
-0.09774992614984512,
-0.2014172077178955,
0.018818503245711327,
0.27703532576560974,
-0.12010205537080765,
0.002429996384307742,
-0.06419536471366882,
-0.017660342156887054,
-0.020382782444357872,
0.2421818971633911,
0.16492041945457458,
0.11610352247953415,
-0.016886454075574875,
-0.11880169808864594,
0.00028279665275476873,
-0.24833111464977264,
-0.03305070474743843,
-0.0063420929946005344,
-0.15121422708034515,
0.011780991218984127,
0.027157623320817947,
-0.07946188002824783,
-0.042517997324466705,
-0.04671284556388855,
-0.19552166759967804,
-0.1994803249835968,
0.16410936415195465,
-0.18582016229629517,
-0.005818604025989771,
0.1312798410654068,
-0.07262705266475677,
-0.07282885164022446,
0.030281804502010345,
0.10955224186182022,
0.1337183266878128,
-0.06812859326601028,
-0.17636877298355103,
-0.16041800379753113,
-0.06499810516834259,
0.04219431430101395,
0.019532930105924606,
-0.2293378859758377,
-0.04447747394442558,
-0.2032972127199173,
0.15315891802310944,
-0.09909272193908691,
-0.05799725279211998,
0.0022126748226583004,
-0.3005436658859253,
0.06071394309401512,
0.18575072288513184,
-0.11671984940767288,
0.07097463309764862,
0.08810863643884659,
-0.02648262307047844,
-0.0009673914755694568,
-0.409294456243515,
0.02061409503221512,
0.09014248102903366,
0.02320197783410549,
-0.2798037528991699,
0.12196940183639526,
-0.3073789179325104,
0.21600854396820068,
-0.11500266194343567,
-0.04984147474169731,
-0.21161310374736786,
0.029485907405614853,
0.2266443371772766,
0.1258004605770111,
-0.14434953033924103,
0.05321406573057175,
-0.1118628978729248,
-0.1468481421470642,
-0.04916726425290108,
-0.00580377085134387,
0.07204088568687439,
0.17773708701133728,
-0.06098303571343422,
-0.1953088343143463,
-0.17304743826389313,
0.048596035689115524,
0.03874555230140686,
-0.00638201180845499,
-0.02124675363302231,
-0.13123828172683716,
0.012058118358254433,
0.07279779016971588,
0.2194257378578186,
0.2922927737236023,
0.03544674068689346,
0.06766722351312637,
-0.15639379620552063,
-0.02366701513528824,
-0.06819717586040497,
-0.13465595245361328,
-0.007119209971278906,
0.05921981856226921,
0.06528064608573914,
0.06130116060376167,
0.07736514508724213,
-0.20485681295394897,
0.025563502684235573,
-0.19128844141960144,
-0.01381478738039732,
0.06925632804632187,
0.3166210949420929,
-0.06826875358819962,
-0.05508895963430405,
-0.04328322038054466,
0.039718687534332275,
-0.06288784742355347,
0.11068359017372131,
0.2813032865524292,
0.22543776035308838,
-0.13574354350566864,
-0.007174220401793718,
-0.34937429428100586,
-0.5088645815849304,
-0.23277391493320465,
0.0966906026005745,
-0.000013981432857690379,
-0.32039472460746765,
0.27902206778526306,
-0.32096952199935913,
0.18995226919651031,
0.08848760277032852,
-0.020998477935791016,
0.14546240866184235,
0.08377860486507416,
-0.11028360575437546,
0.04682305082678795,
-0.22402505576610565,
0.021895838901400566,
-0.010009578429162502,
-0.05146624520421028,
-0.0888618752360344,
0.2047455906867981,
-0.07894138991832733,
0.018170366063714027,
-0.1607580929994583,
-0.03491455316543579,
0.2759745419025421,
0.09163688123226166,
-0.05527092516422272,
-0.017983561381697655,
0.004842753056436777,
0.1039954200387001,
-0.31133735179901123,
0.06073491647839546,
-0.0828949585556984,
-0.07493817806243896,
0.057697270065546036,
-0.051563963294029236,
-0.15834254026412964,
0.22030536830425262,
-0.04653540998697281,
0.27660152316093445,
0.13340558111667633,
0.18880143761634827,
-0.05298665910959244,
0.46721014380455017,
-0.082394078373909,
0.12825718522071838,
-0.308155357837677,
-0.14730992913246155,
0.22619138658046722,
-0.1011243686079979,
-0.001722667715512216,
-0.023719925433397293,
-0.14471113681793213,
0.19121797382831573,
0.1650974005460739,
-0.05542977526783943,
0.18255935609340668,
-0.09006449580192566,
0.14552035927772522,
-0.10889695584774017,
0.00253819371573627,
-0.16402535140514374,
0.023809663951396942,
-0.07372051477432251,
0.07438794523477554,
-0.08886963129043579,
0.06850074231624603,
-0.15776321291923523,
0.055038850754499435,
-0.2200292944908142,
-0.18111823499202728,
0.11029095202684402,
-0.07780329883098602,
-0.0014014523476362228,
0.1490193009376526,
-0.28715622425079346,
0.25837478041648865,
0.23137463629245758,
-0.08205436170101166,
-0.037931960076093674,
0.005800039507448673,
0.26462504267692566,
-0.1339782476425171,
0.028089042752981186,
-0.14167647063732147,
-0.04138742387294769,
-0.12573041021823883,
-0.008126380853354931,
0.14055904746055603,
0.15418758988380432,
-0.10656433552503586,
0.21249549090862274,
-0.2653701901435852,
-0.22738908231258392,
-0.05734165757894516,
-0.010062813758850098,
0.049674224108457565,
0.08418810367584229,
0.12026701867580414,
-0.17352166771888733,
0.15724745392799377,
-0.03301287814974785,
0.23433126509189606,
-0.05702158436179161,
-0.3648473024368286,
-0.16651038825511932,
-0.05617951229214668,
-0.07164560258388519,
0.15191258490085602,
0.04073460400104523,
0.14919131994247437,
0.025415105745196342,
-0.2857477068901062,
0.08756694197654724,
0.05054716020822525,
0.0483076386153698,
0.1706681102514267,
-0.08431342989206314,
-0.05217471718788147,
0.3823983669281006,
-0.07057365030050278,
-0.24568475782871246,
-0.03658238425850868,
-0.09739950299263,
-0.013036930002272129,
0.09517867118120193,
0.2300487607717514,
-0.17525000870227814,
-0.06246866285800934,
0.29574477672576904,
-0.23697546124458313,
-0.01384896133095026,
-0.19368723034858704,
0.029534408822655678,
-0.17479871213436127,
0.14147651195526123,
0.07618974894285202,
-0.0901288315653801,
0.034083448350429535,
-0.025627048686146736,
0.07378316670656204,
-0.08993570506572723,
-0.2820889949798584,
0.015767958015203476,
-0.04166698083281517,
0.005333730485290289,
-0.14587725698947906,
0.06111470237374306,
0.06140030175447464,
-0.15375298261642456,
0.46551936864852905,
0.204692080616951,
-0.08700220286846161,
-0.14293745160102844,
0.010587346740067005,
-0.2550944983959198,
0.13715845346450806,
0.011656936258077621,
0.09836824238300323,
-0.008062190376222134,
0.008424672298133373,
-0.04913259670138359,
-0.25654786825180054,
-0.043920792639255524,
-0.06348186731338501,
-0.10652026534080505,
-0.1837000846862793,
-0.0004627462476491928,
0.047698866575956345,
0.007513159420341253,
-0.23492716252803802,
0.0014642965979874134,
-0.08850457519292831,
0.08469680696725845,
0.2670441269874573,
0.048395175486803055,
0.011478928849101067,
0.07424397021532059,
0.011070994660258293,
-0.026810297742486,
-0.07138963043689728,
-0.038848165422677994,
-0.0698605626821518,
-0.19719968736171722,
-0.09066672623157501,
0.07452746480703354,
0.1393260657787323,
-0.022683579474687576,
0.21024560928344727,
-0.12966980040073395,
-0.06429877132177353
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. 6. Exon deletions account for to ~20% of PCCA disease-causing alleles .7. Three PCCB large-deletion alleles have been described .II. An alternative approach involves the assay of propionyl-CoA carboxylase (PCC) enzyme activity in lymphocytes or cultured skin fibroblasts followed by molecular diagnosis . In individuals with equivocal molecular genetic test results, a combination of enzymatic and molecular diagnostics may be necessary.Clinical CharacteristicsClinical DescriptionPropionic acidemia presents with a wide spectrum of symptoms and age of onset. The onset of symptoms in PA varies depending on several factors including residual enzymatic activity, intake of propiogenic precursors, and the occurrence of catabolic stressors. See Table 3a (pdf) and Table 3b (pdf) for a summary of major clinical findings in propionic acidemia (PA) and the reported frequency of symptoms.Perinatal course. Reported maternal prenatal course, gestational age, and birth length, weight, and head circumference are similar to what is reported for unaffected infants | [
-0.11845313757658005,
0.1518552154302597,
-0.04593989625573158,
-0.2742341458797455,
0.2708375155925751,
-0.09802448749542236,
0.13450536131858826,
-0.25168606638908386,
0.010348035953938961,
-0.043920475989580154,
0.1427549421787262,
0.07729341089725494,
-0.006555390078574419,
0.04739058017730713,
-0.3755306601524353,
0.23469983041286469,
0.15270370244979858,
-0.1214943528175354,
-0.056667327880859375,
-0.09054785221815109,
0.011313087306916714,
-0.1242419183254242,
0.06732039153575897,
0.06918665766716003,
0.19014449417591095,
-0.11522932350635529,
0.11885577440261841,
-0.2870247960090637,
0.16731899976730347,
0.05697297304868698,
0.13337945938110352,
0.011352566070854664,
0.10043273866176605,
-0.3124443590641022,
0.033812157809734344,
-0.24675244092941284,
-0.040084052830934525,
-0.12145339697599411,
0.04843323305249214,
-0.2592301368713379,
0.07769498229026794,
-0.13403278589248657,
0.30708765983581543,
-0.1183168813586235,
0.214183047413826,
0.07682209461927414,
-0.06924207508563995,
-0.005702857859432697,
-0.04210307076573372,
0.16560624539852142,
0.24006976187229156,
-0.10431485623121262,
-0.19273701310157776,
-0.12149162590503693,
0.15803050994873047,
-0.09980018436908722,
-0.19555871188640594,
-0.05067950487136841,
-0.35039377212524414,
0.04979696124792099,
0.08022306114435196,
-0.1416860669851303,
-0.1217736154794693,
-0.19247102737426758,
0.21505896747112274,
-0.10041925311088562,
0.017372269183397293,
0.08564012497663498,
0.1890377700328827,
-0.11247707903385162,
0.07240699976682663,
-0.1488160640001297,
0.0616949088871479,
0.14881108701229095,
-0.044124118983745575,
-0.0029949035961180925,
-0.022706395015120506,
-0.04859057813882828,
0.04344824701547623,
-0.3623272478580475,
-0.19281665980815887,
0.029189353808760643,
0.12499579787254333,
-0.09034733474254608,
-0.1212054044008255,
0.013725271448493004,
0.230251282453537,
-0.07841315865516663,
-0.00017346137610729784,
0.2206866592168808,
0.17233474552631378,
-0.049728672951459885,
0.12837421894073486,
-0.030516568571329117,
0.08804035186767578,
-0.23298929631710052,
0.1408107578754425,
0.028344882652163506,
-0.26529452204704285,
0.030028918758034706,
0.06606485694646835,
0.0017597908154129982,
-0.1872745156288147,
0.015722382813692093,
-0.06005958095192909,
0.06489481031894684,
-0.09170999377965927,
-0.05411827936768532,
-0.04286773502826691,
0.11748965084552765,
0.18822868168354034,
-0.2113240510225296,
0.01123716775327921,
-0.05342753231525421,
-0.38165801763534546,
-0.0010894732549786568,
-0.0822623074054718,
0.2933344542980194,
-0.08597525209188461,
0.12068241089582443,
-0.08035324513912201,
0.06152947619557381,
0.007008243352174759,
-0.027880078181624413,
-0.16373641788959503,
0.11044518649578094,
-0.02485179342329502,
0.02867083065211773,
0.26089194416999817,
-0.08054113388061523,
0.0019011214608326554,
0.04988746717572212,
-0.05342993885278702,
-0.03605831786990166,
0.1627928614616394,
-0.08660674840211868,
-0.36531123518943787,
-0.37741440534591675,
-0.06974463909864426,
-0.043136369436979294,
0.12660501897335052,
0.15857256948947906,
0.16945844888687134,
0.13748373091220856,
0.2303585410118103,
0.07787702232599258,
0.40911731123924255,
-0.011855301447212696,
0.08632459491491318,
0.03272346779704094,
-0.030435046181082726,
-0.2450026422739029,
0.1458244025707245,
0.02591463178396225,
-0.05510900542140007,
0.14435945451259613,
0.04026961326599121,
0.1865510493516922,
-0.17668956518173218,
0.07706037908792496,
0.03902683034539223,
0.0033930116333067417,
0.00857875682413578,
-0.07592509686946869,
0.006489041727036238,
0.016810327768325806,
-0.3283769190311432,
-0.01214614324271679,
-0.06693246960639954,
-0.057397566735744476,
-0.10033396631479263,
-0.005334203131496906,
0.09083770215511322,
0.2116822600364685,
0.08027928322553635,
0.1498263031244278,
-0.20274308323860168,
-0.019477684050798416,
0.0008813563617877662,
0.13009797036647797,
0.18686899542808533,
0.08021721988916397,
-0.26844847202301025,
-0.06119277700781822,
-0.018321622163057327,
-0.16117741167545319,
0.23871180415153503,
0.1848127692937851,
-0.09123815596103668,
0.16885145008563995,
0.21251927316188812,
-0.07000166177749634,
0.0006757430965080857,
0.03641149401664734,
0.014224247075617313,
-0.2402675747871399,
0.08791469782590866,
0.047657277435064316,
-0.1743202805519104,
0.026872802525758743,
-0.03456123545765877,
-0.032661233097314835,
0.06285834312438965,
-0.03734314814209938,
-0.0559539869427681,
-0.07229479402303696,
0.03861759230494499,
-0.0813593938946724,
0.05014694482088089,
0.23700197041034698,
-0.07095133513212204,
0.2216266691684723,
-0.2809600532054901,
0.07445576041936874,
-0.20085172355175018,
-0.12847235798835754,
0.06089795008301735,
-0.1380191296339035,
0.06903830170631409,
0.14825616776943207,
0.0953693613409996,
0.04654381051659584,
0.031813252717256546,
-0.27653881907463074,
0.04264504089951515,
0.14268594980239868,
-0.3655551075935364,
-0.15029360353946686,
0.06956441700458527,
-0.22333773970603943,
-0.0341547466814518,
-0.00859634205698967,
-0.021440519019961357,
0.15987063944339752,
-0.11332805454730988,
-0.17037153244018555,
-0.23604917526245117,
0.2839607000350952,
-0.030201366171240807,
0.09212672710418701,
-0.3800608813762665,
-0.06456336379051208,
0.08696900308132172,
0.05579569563269615,
-0.06828726828098297,
0.051747892051935196,
-0.0015418515540659428,
0.12794482707977295,
-0.02483699657022953,
0.19723650813102722,
-0.0249271709471941,
0.10174071788787842,
-0.08935893326997757,
0.0441281720995903,
-0.30475953221321106,
-0.17806555330753326,
0.03450535982847214,
0.004691067151725292,
0.10586339980363846,
0.0232319887727499,
-0.034035127609968185,
0.18801409006118774,
0.14991633594036102,
0.08016318827867508,
-0.09142694622278214,
-0.007292988244444132,
-0.18576699495315552,
0.06455446779727936,
0.029654810205101967,
-0.16690172255039215,
-0.03716279938817024,
0.158965066075325,
0.1546206772327423,
0.13567610085010529,
-0.21062208712100983,
-0.17268703877925873,
0.03743916004896164,
0.07395118474960327,
0.060614001005887985,
0.057982586324214935,
-0.11679583787918091,
0.26026099920272827,
-0.13319654762744904,
0.14847275614738464,
0.17977167665958405,
0.0890611931681633,
-0.04082038998603821,
-0.033185847103595734,
-0.08099284768104553,
0.07086804509162903,
-0.058751147240400314,
0.19549936056137085,
-0.14855070412158966,
-0.02577883191406727,
0.10028534382581711,
0.1862816959619522,
-0.1201932355761528,
0.03818507492542267,
-0.014536301605403423,
-0.015111850574612617,
0.06336359679698944,
0.07020968198776245,
0.25058308243751526,
-0.17214561998844147,
-0.33172789216041565,
-0.014595985412597656,
-0.009945455938577652,
-0.08546002954244614,
0.11318058520555496,
0.23614445328712463,
-0.12250308692455292,
-0.13465233147144318,
-0.18914437294006348,
0.109880730509758,
-0.08870486915111542,
-0.1081162840127945,
0.06684073060750961,
0.089215487241745,
0.2438322901725769,
0.2613486349582672,
-0.08617783337831497,
0.08138934522867203,
0.07259903103113174,
0.029740093275904655,
-0.26103097200393677,
-0.004314695484936237,
-0.12199045717716217,
0.0004472000291571021,
-0.1197526752948761,
0.09494952112436295,
-0.04151679202914238,
0.10309680551290512,
0.10742049664258957,
-0.12362400442361832,
0.3387751281261444,
-0.012464629486203194,
0.36793258786201477,
0.03273831680417061,
-0.05661335960030556,
0.2180396020412445,
0.12438899278640747,
-0.35730037093162537,
-0.07698295265436172,
-0.11750397831201553,
-0.28693100810050964,
0.04393649846315384,
-0.0013750593643635511,
0.0736614242196083,
0.14366818964481354,
-0.18185415863990784,
-0.024749815464019775,
0.0662507638335228,
-0.05906962230801582,
-0.2131413221359253,
0.25131940841674805,
-0.04400534927845001,
-0.026078518480062485,
0.1676071435213089,
0.05267005041241646,
0.10969778895378113,
-0.26413899660110474,
-0.026592068374156952,
0.24112845957279205,
-0.1114160418510437,
0.09153708070516586,
-0.21041065454483032,
-0.029895586892962456,
0.08066370338201523,
0.11943675577640533,
0.06884042918682098,
0.09030977636575699,
0.15070734918117523,
-0.0011949038598686457,
0.11439649015665054,
-0.021320529282093048,
0.21149398386478424,
-0.19157250225543976,
0.1322326511144638,
-0.26484736800193787,
-0.1697809249162674,
0.17025260627269745,
-0.025266174226999283,
0.1768645942211151,
-0.013717309571802616,
0.05741750821471214,
0.0742376521229744,
-0.0671350359916687,
0.2228747010231018,
0.17221885919570923,
-0.40624916553497314,
0.08887741714715958,
0.11253179609775543,
-0.019781893119215965,
0.11237688362598419,
0.004753507673740387,
0.2357424795627594,
-0.01167308446019888,
0.013502629473805428,
-0.1818510890007019,
0.12599222362041473,
-0.13604159653186798,
-0.12166901677846909,
0.0985531136393547,
0.22425426542758942,
0.16395121812820435,
0.05477442219853401,
-0.0026822658255696297,
0.08454789966344833,
-0.11958654969930649,
0.10788377374410629,
-0.06872629374265671,
-0.03674739599227905,
0.04907331243157387,
-0.1859617680311203,
-0.17726270854473114,
-0.11943990737199783,
-0.1362031102180481,
0.015977632254362106,
0.019652554765343666,
-0.10492445528507233,
-0.09949495643377304,
-0.02718387544155121,
0.1444757729768753,
-0.05456903949379921,
-0.13433288037776947,
-0.03533996269106865,
0.14415933191776276,
-0.06785276532173157,
0.060814544558525085,
0.07650566846132278,
0.21641801297664642,
-0.07677693665027618,
-0.23715554177761078,
-0.013617655262351036,
0.037603698670864105,
0.1217053011059761,
-0.07974211126565933,
0.042455390095710754,
0.019255351275205612,
-0.1202259361743927,
0.1531171053647995,
0.020258933305740356,
-0.145183265209198,
-0.0777026116847992,
-0.17009423673152924,
0.23678049445152283,
0.22501009702682495,
0.18296176195144653,
0.05636658892035484,
0.18947045505046844,
0.060290828347206116,
-0.084177665412426,
-0.09030889719724655,
-0.0728655457496643,
0.030569730326533318,
0.07471514493227005,
0.019167156890034676,
-0.15675972402095795,
0.07704474031925201,
0.04708312451839447,
-0.15323345363140106,
0.16868357360363007,
0.2067994773387909,
-0.10592736303806305,
-0.15240472555160522,
0.00012077541759936139,
-0.18726061284542084,
-0.01602569967508316,
0.14255525171756744,
-0.019798889756202698,
0.1817367970943451,
0.05995697155594826,
-0.11110242456197739,
0.05313990265130997,
-0.2812346816062927,
-0.1131686419248581,
-0.10177243500947952,
-0.1083105057477951,
-0.026751181110739708,
0.0327875129878521,
-0.04517926648259163,
-0.24418364465236664,
0.021890614181756973,
-0.07713963836431503,
-0.1051599383354187,
0.1610739827156067,
-0.19916915893554688,
-0.14492808282375336,
0.18154941499233246,
0.015184685587882996,
-0.10286887735128403,
0.12032531946897507,
0.07933047413825989,
0.20785589516162872,
0.01045166328549385,
-0.22612254321575165,
0.02511872537434101,
-0.09097970277070999,
0.04914801940321922,
0.008242128416895866,
-0.1832992434501648,
-0.10894975066184998,
-0.154618039727211,
0.22897683084011078,
-0.07097221910953522,
0.016300875693559647,
-0.08045143634080887,
-0.2601654529571533,
0.02172493003308773,
0.2950286269187927,
-0.10311831533908844,
0.11053545027971268,
-0.0426323376595974,
-0.054055105894804,
-0.09745723009109497,
-0.29284051060676575,
0.10372103005647659,
0.26976948976516724,
0.026319678872823715,
-0.24213236570358276,
0.11621639877557755,
-0.09603473544120789,
0.29928672313690186,
-0.047870736569166183,
0.007222551852464676,
-0.11388309299945831,
0.036452777683734894,
0.15624848008155823,
-0.0028956509195268154,
-0.12880845367908478,
0.016361983492970467,
-0.12320136278867722,
-0.14418426156044006,
0.05329972505569458,
0.25326403975486755,
-0.006629981566220522,
0.15281566977500916,
-0.16224747896194458,
-0.17026197910308838,
-0.08894700556993484,
-0.10609570145606995,
-0.04439113289117813,
-0.01968264952301979,
-0.02845471166074276,
-0.2160252183675766,
0.15001212060451508,
0.15641656517982483,
0.1261851042509079,
0.04554256051778793,
-0.015936609357595444,
-0.0397808738052845,
-0.07160898298025131,
0.0772353783249855,
0.02661048248410225,
-0.04988513141870499,
-0.1781916469335556,
-0.08059243112802505,
-0.04839237406849861,
-0.18854856491088867,
-0.023512547835707664,
-0.16013598442077637,
0.08637908846139908,
-0.21726609766483307,
0.05491619184613228,
0.00926987361162901,
0.20441146194934845,
-0.0578448511660099,
-0.16590619087219238,
-0.0093781603500247,
-0.000025474739231867716,
0.015591016039252281,
0.060659222304821014,
0.15513600409030914,
-0.06148070469498634,
-0.1239369809627533,
0.007494311314076185,
-0.17077693343162537,
-0.4548276960849762,
-0.11432977020740509,
0.1722615659236908,
0.00685563450679183,
-0.15439924597740173,
0.10938791930675507,
-0.26741302013397217,
-0.03593739494681358,
0.041015636175870895,
0.04320285841822624,
0.029102563858032227,
0.15227077901363373,
-0.017416443675756454,
-0.006368538830429316,
-0.09174859523773193,
0.036033760756254196,
-0.01051971036940813,
0.03873337432742119,
-0.25669005513191223,
0.2732158601284027,
-0.13313058018684387,
0.04308226704597473,
0.025815678760409355,
0.12865549325942993,
0.22255286574363708,
-0.032049838453531265,
-0.16181406378746033,
0.06952426582574844,
-0.09173636138439178,
0.0591968409717083,
-0.3244503438472748,
-0.058483440428972244,
0.004949565511196852,
0.11888262629508972,
-0.06529713422060013,
0.052693720906972885,
-0.05890349671244621,
0.08788041770458221,
0.011141031049191952,
0.29503175616264343,
0.05536341667175293,
0.214975506067276,
-0.026312051340937614,
0.3213271498680115,
-0.0038360413163900375,
0.05117899551987648,
-0.20239070057868958,
-0.12334026396274567,
0.1261155903339386,
-0.04452909156680107,
-0.08906670659780502,
0.05974557623267174,
-0.05149427056312561,
0.09071847051382065,
0.3099741041660309,
-0.0711444765329361,
0.03784523904323578,
-0.15826089680194855,
0.07717519253492355,
-0.024494031444191933,
0.1202317401766777,
-0.2317308634519577,
0.11460626870393753,
-0.18563249707221985,
0.15184295177459717,
-0.15619969367980957,
0.12036901712417603,
-0.3429330587387085,
0.025390857830643654,
-0.19708748161792755,
-0.08306367695331573,
-0.017301833257079124,
-0.11222842335700989,
-0.0355234257876873,
0.06740478426218033,
-0.05663639307022095,
0.26437345147132874,
0.31982681155204773,
-0.11658281087875366,
0.1309630125761032,
0.010233993642032146,
0.2714572250843048,
-0.16292735934257507,
-0.0737006664276123,
0.042807288467884064,
0.0559922493994236,
-0.10961591452360153,
-0.10843797028064728,
0.1512921154499054,
0.19021640717983246,
0.060410380363464355,
0.07903385907411575,
-0.2995605170726776,
-0.05399325489997864,
0.0053238896653056145,
-0.02570543810725212,
0.14691254496574402,
0.05040086805820465,
0.15230214595794678,
-0.07263753563165665,
0.08308438956737518,
-0.09571433812379837,
0.3273107707500458,
0.01362285390496254,
-0.4290718734264374,
-0.20923227071762085,
-0.05244968459010124,
-0.00864486675709486,
0.15321987867355347,
-0.019287943840026855,
0.005542537663131952,
0.20954854786396027,
-0.28530609607696533,
0.06250694394111633,
-0.16048651933670044,
0.057401906698942184,
0.16177834570407867,
0.10828907787799835,
0.045583564788103104,
0.36963900923728943,
-0.14412501454353333,
-0.25422802567481995,
-0.1066541001200676,
-0.12910127639770508,
0.06303393840789795,
0.03633721172809601,
0.24742445349693298,
-0.17352890968322754,
-0.14258795976638794,
0.11634664237499237,
-0.21519255638122559,
0.03819379583001137,
-0.08870850503444672,
-0.05249248072504997,
-0.1134055107831955,
-0.008444818668067455,
0.11670588701963425,
0.0030125058256089687,
0.15101806819438934,
-0.12646038830280304,
0.19963684678077698,
-0.19491814076900482,
-0.12974169850349426,
0.10296716541051865,
0.09953933954238892,
0.03437642753124237,
-0.08953462541103363,
-0.0017175773391500115,
0.08634469658136368,
-0.08514600247144699,
0.1726088970899582,
0.23647849261760712,
-0.03161010518670082,
-0.1434950828552246,
-0.03690901771187782,
-0.3475681245326996,
0.14117932319641113,
-0.10759245604276657,
0.08364168554544449,
0.04399704560637474,
0.006744917016476393,
-0.07501884549856186,
-0.3040604591369629,
0.0006027229828760028,
0.13011692464351654,
-0.008594078943133354,
-0.137405127286911,
0.09386784583330154,
0.15530210733413696,
-0.0052589960396289825,
-0.18525488674640656,
-0.042482249438762665,
-0.10338358581066132,
0.03554019331932068,
0.2642029821872711,
0.0004703393206000328,
-0.012593698687851429,
0.011516373604536057,
0.00040847164927981794,
0.04709632694721222,
-0.20525485277175903,
0.10916975885629654,
-0.11800377070903778,
-0.14926087856292725,
0.016173409298062325,
0.027900591492652893,
0.0276139285415411,
-0.21559475362300873,
0.1983853429555893,
-0.022742729634046555,
0.04278166964650154
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. spectrum of symptoms and age of onset. The onset of symptoms in PA varies depending on several factors including residual enzymatic activity, intake of propiogenic precursors, and the occurrence of catabolic stressors. See Table 3a (pdf) and Table 3b (pdf) for a summary of major clinical findings in propionic acidemia (PA) and the reported frequency of symptoms.Perinatal course. Reported maternal prenatal course, gestational age, and birth length, weight, and head circumference are similar to what is reported for unaffected infants . Increased frequency of miscarriages of affected fetuses is possible .Neonatal onset PA. A typical presentation of PA in the neonatal period is characterized by a healthy newborn with poor feeding and decreased arousal in the first few days of life, followed by progressive encephalopathy of unexplained origin. Without prompt diagnosis and management, neonates can develop progressive encephalopathy manifesting as lethargy, seizures, or coma that can result in death (see Table 2). Most individuals eventually diagnosed with PA become symptomatic in | [
-0.13594461977481842,
0.09220073372125626,
-0.017948884516954422,
-0.28160467743873596,
0.06027914583683014,
0.010084680281579494,
0.013012407347559929,
-0.24117830395698547,
-0.06808991730213165,
-0.11397823691368103,
0.009849263355135918,
0.06136463209986687,
-0.00948468130081892,
0.12060181796550751,
-0.2630857229232788,
0.15670667588710785,
0.09023189544677734,
0.03575533255934715,
-0.14546428620815277,
-0.045179545879364014,
0.10460121929645538,
-0.26522186398506165,
-0.10494814068078995,
0.14297588169574738,
0.3106982409954071,
-0.13344301283359528,
0.2751557230949402,
-0.39138680696487427,
0.29070475697517395,
0.12786418199539185,
0.016296133399009705,
0.20239423215389252,
-0.05732325464487076,
-0.38589543104171753,
-0.032247211784124374,
-0.08800838142633438,
-0.06214690953493118,
-0.17460384964942932,
0.05600644648075104,
-0.3182436227798462,
0.04142310470342636,
-0.08067000657320023,
0.20302879810333252,
-0.17421239614486694,
0.20882877707481384,
0.010655248537659645,
-0.08710178732872009,
-0.044379353523254395,
-0.07752467691898346,
0.25871527194976807,
0.2139202356338501,
0.03632834926247597,
-0.25741279125213623,
0.0020735522266477346,
0.14949093759059906,
-0.1761811077594757,
-0.09229756891727448,
-0.025478452444076538,
-0.2840357720851898,
0.129204660654068,
0.10943936556577682,
-0.2658669054508209,
-0.0682908371090889,
-0.28532370924949646,
0.11064142733812332,
-0.01888331025838852,
0.05553879961371422,
0.13171091675758362,
0.1512768715620041,
-0.27130863070487976,
0.034903425723314285,
0.06812120229005814,
-0.061488986015319824,
0.11774051934480667,
0.020681794732809067,
0.0034018021542578936,
0.09033971279859543,
0.1867973506450653,
-0.1876182109117508,
-0.3472866415977478,
-0.18012535572052002,
-0.019986582919955254,
-0.012824269942939281,
-0.07038664817810059,
-0.09610399603843689,
0.005396964028477669,
0.29759716987609863,
0.04894755780696869,
0.04207022488117218,
0.19408270716667175,
0.18198679387569427,
-0.04332754388451576,
-0.10169773548841476,
-0.162366583943367,
0.09008528292179108,
-0.09813977032899857,
0.16354526579380035,
-0.028691938146948814,
-0.185055673122406,
0.10841105133295059,
0.0651300847530365,
-0.05445755273103714,
-0.028279984369874,
0.15973536670207977,
0.02946546860039234,
0.15668603777885437,
-0.09868140518665314,
-0.007355378475040197,
-0.09321825206279755,
0.08496227115392685,
-0.04275261238217354,
-0.1847798228263855,
0.1620878130197525,
-0.07559642940759659,
-0.5420318245887756,
-0.08840469270944595,
-0.14466740190982819,
0.2572343349456787,
-0.014632872305810452,
0.05431828275322914,
-0.02134971134364605,
0.10248906910419464,
0.04445814713835716,
-0.15190517902374268,
-0.04020389914512634,
0.03519356623291969,
0.00817221961915493,
0.10630439966917038,
0.23513054847717285,
-0.09992603212594986,
-0.10764584690332413,
-0.044148433953523636,
0.002350797411054373,
-0.03594173491001129,
0.27126240730285645,
-0.022064637392759323,
-0.31609565019607544,
-0.3059535324573517,
-0.054504454135894775,
-0.1369403451681137,
0.04122057184576988,
0.28811338543891907,
0.27576106786727905,
0.12887641787528992,
0.22566166520118713,
0.047921113669872284,
0.39590615034103394,
0.07903911173343658,
0.2637901306152344,
0.05228481814265251,
-0.060185931622982025,
-0.06497635692358017,
0.30015864968299866,
0.032075803726911545,
0.008180715143680573,
0.2610999345779419,
0.0629979595541954,
0.2742331027984619,
-0.10150550305843353,
0.09391315281391144,
-0.133600115776062,
-0.027519825845956802,
0.07929303497076035,
0.01773969456553459,
-0.21072274446487427,
-0.05383855104446411,
-0.4962235689163208,
0.003742663422599435,
-0.12494406849145889,
-0.18157915771007538,
-0.048114269971847534,
0.027124738320708275,
-0.08355073630809784,
0.12768474221229553,
-0.043154701590538025,
0.10595564544200897,
-0.1230039894580841,
0.05621315538883209,
-0.08220293372869492,
0.22241996228694916,
0.10505363345146179,
-0.12408760190010071,
-0.25067752599716187,
-0.010590271092951298,
-0.0514337420463562,
-0.11817124485969543,
0.24493330717086792,
0.31296274065971375,
-0.09721053391695023,
0.19220559298992157,
0.2343154400587082,
0.16683252155780792,
-0.06444036960601807,
0.1287376433610916,
-0.0306935366243124,
-0.24119779467582703,
0.19590993225574493,
-0.0029807405080646276,
-0.10848163813352585,
0.04773165285587311,
-0.09325412660837173,
-0.17894092202186584,
0.20147113502025604,
-0.19732612371444702,
-0.00676560215651989,
-0.1504414826631546,
-0.012106029316782951,
-0.07735500484704971,
-0.028537997975945473,
0.1760030835866928,
-0.09812518209218979,
0.2911732494831085,
-0.08058428019285202,
0.06306034326553345,
-0.31010910868644714,
-0.167106494307518,
0.11601252853870392,
-0.027210703119635582,
-0.03797851875424385,
0.18295161426067352,
-0.0901363343000412,
-0.08496921509504318,
-0.05835283547639847,
-0.19082097709178925,
-0.05115717649459839,
-0.09518150240182877,
-0.4235111176967621,
-0.19904263317584991,
0.19021818041801453,
-0.25100913643836975,
-0.151450514793396,
0.09029050916433334,
-0.07867302745580673,
0.1793292909860611,
0.01501978375017643,
-0.11713594198226929,
-0.19906409084796906,
0.41050606966018677,
-0.1844465285539627,
-0.004508768208324909,
-0.4135913848876953,
-0.18164953589439392,
-0.011418560519814491,
0.10166419297456741,
-0.09867093712091446,
0.0360131673514843,
-0.07145612686872482,
0.04548591375350952,
0.08203887939453125,
0.059442538768053055,
0.011216238141059875,
0.048496078699827194,
-0.054588768631219864,
0.1420583873987198,
-0.364820271730423,
-0.17280438542366028,
0.1337069720029831,
0.01555209793150425,
0.06435772776603699,
0.014245991595089436,
-0.1354450285434723,
0.37225431203842163,
0.06667471677064896,
0.059337068349123,
0.17442229390144348,
-0.0467466376721859,
-0.14198453724384308,
0.14356516301631927,
-0.022049112245440483,
-0.3138532042503357,
-0.15524816513061523,
0.2614387571811676,
0.05572152137756348,
0.09389801323413849,
-0.28708380460739136,
-0.24383042752742767,
0.05851424112915993,
0.11118528991937637,
0.10715348273515701,
-0.16745808720588684,
-0.09833209216594696,
0.222298726439476,
-0.01007431373000145,
-0.006453004200011492,
0.23708707094192505,
0.17190730571746826,
0.07054644823074341,
0.10630771517753601,
-0.004502434749156237,
0.0862012580037117,
-0.019080208614468575,
0.2512345314025879,
-0.25745439529418945,
-0.08966072648763657,
0.1186760887503624,
0.23770835995674133,
-0.047469768673181534,
0.07526563853025436,
0.00048308054101653397,
0.04940788075327873,
0.07935800403356552,
0.1566186398267746,
0.2849750816822052,
-0.0968620702624321,
-0.3160499334335327,
-0.029083378612995148,
-0.007872438989579678,
-0.02033127099275589,
0.12005191296339035,
0.24431969225406647,
-0.0942157655954361,
-0.0849556177854538,
-0.11718205362558365,
0.14185857772827148,
-0.12665189802646637,
-0.09824362397193909,
-0.07425259053707123,
0.12541019916534424,
0.2160957157611847,
0.2282090038061142,
-0.08490227162837982,
0.031293150037527084,
-0.005173094104975462,
0.09224680066108704,
-0.2222486287355423,
-0.04117906466126442,
-0.08122020214796066,
-0.027314962819218636,
-0.12081120163202286,
0.07781027257442474,
-0.15705333650112152,
0.13088184595108032,
-0.011958607472479343,
-0.3036215901374817,
0.29549723863601685,
-0.23139165341854095,
0.2606086730957031,
0.00547552015632391,
-0.14107051491737366,
0.0821855291724205,
0.0800456702709198,
-0.3010176718235016,
-0.026721669360995293,
-0.3104546368122101,
-0.28106412291526794,
0.07234100997447968,
-0.12794704735279083,
0.13165880739688873,
0.0643322691321373,
0.0036017107777297497,
-0.08340253680944443,
0.0353204645216465,
-0.2465277910232544,
-0.2219231128692627,
0.09609141945838928,
-0.19110900163650513,
-0.015393059700727463,
0.06306338310241699,
0.11375046521425247,
0.02536868304014206,
-0.3432881534099579,
-0.0284926388412714,
0.18079543113708496,
-0.1000828742980957,
0.1713266521692276,
-0.20668736100196838,
0.07235316187143326,
-0.11995559185743332,
0.22573041915893555,
0.019806930795311928,
0.07152697443962097,
0.13740870356559753,
-0.0021337061189115047,
0.14740201830863953,
-0.14628145098686218,
0.14145751297473907,
-0.193495973944664,
0.1642915904521942,
-0.2372460663318634,
-0.09054797142744064,
0.1811583936214447,
0.009844929911196232,
0.15459774434566498,
-0.029307488352060318,
0.003165737260133028,
0.05356309935450554,
0.002738295355811715,
0.36131733655929565,
0.28841158747673035,
-0.4062023460865021,
0.06551720947027206,
0.16260282695293427,
-0.1651042252779007,
0.19006794691085815,
0.13614754378795624,
0.09287843853235245,
-0.023062139749526978,
0.09793412685394287,
-0.09426895529031754,
0.11245018243789673,
-0.03831671178340912,
-0.009076839312911034,
0.09066709131002426,
0.11271946132183075,
0.09740463644266129,
0.10975845158100128,
0.19722475111484528,
0.07066496461629868,
-0.20174449682235718,
0.057601239532232285,
-0.10145820677280426,
-0.005732874386012554,
-0.03928500413894653,
-0.29524487257003784,
-0.2194473147392273,
-0.06401651352643967,
-0.08338432013988495,
-0.03166503831744194,
0.007775298785418272,
-0.1093323826789856,
-0.10037335753440857,
-0.13215599954128265,
0.18672795593738556,
-0.08106378465890884,
-0.09566131979227066,
-0.001164978719316423,
0.03814687579870224,
-0.03990544006228447,
0.04994791001081467,
0.2056017369031906,
0.20492270588874817,
-0.16557826101779938,
-0.14002838730812073,
0.01976233907043934,
0.03074324131011963,
0.019838634878396988,
-0.11635526269674301,
0.09891623258590698,
-0.1713777482509613,
-0.16745100915431976,
0.0704609751701355,
0.12278058379888535,
-0.05086647719144821,
0.06253629177808762,
-0.21075086295604706,
0.26202383637428284,
0.180330291390419,
0.09924108535051346,
-0.05142959952354431,
0.1595984250307083,
0.10993626713752747,
0.08139250427484512,
-0.06402267515659332,
0.04979643225669861,
-0.00431182561442256,
0.1369038075208664,
0.05526342988014221,
-0.050231434404850006,
0.07222253084182739,
0.035323869436979294,
-0.029394889250397682,
0.23610052466392517,
0.18109463155269623,
-0.24388545751571655,
-0.2808627188205719,
-0.0012695729965344071,
-0.10674619674682617,
0.10385581105947495,
-0.09830871969461441,
-0.08020199835300446,
-0.012820035219192505,
-0.0009639653726480901,
-0.15184083580970764,
0.05095764622092247,
-0.17582541704177856,
-0.19003328680992126,
-0.05371835082769394,
-0.07586371153593063,
0.01654115878045559,
-0.007379119750112295,
-0.04849295690655708,
-0.21451544761657715,
0.1371219903230667,
0.028784647583961487,
-0.03383997455239296,
0.10834560543298721,
-0.3251135051250458,
-0.027392486110329628,
0.2792718708515167,
-0.056035153567790985,
-0.11889120191335678,
-0.038177747279405594,
-0.049295488744974136,
0.26804661750793457,
0.006005754228681326,
-0.29825901985168457,
-0.11452289670705795,
-0.13194535672664642,
-0.046986714005470276,
0.07973608374595642,
-0.08141987025737762,
-0.03603198006749153,
-0.09820776432752609,
-0.0750199481844902,
-0.004653432872146368,
-0.003949131816625595,
-0.08466622233390808,
-0.1738734096288681,
0.03570689633488655,
0.17659886181354523,
0.005380305461585522,
0.16095900535583496,
-0.17086593806743622,
-0.08393136411905289,
0.08117834478616714,
-0.08593804389238358,
0.20406946539878845,
0.34081196784973145,
0.12893138825893402,
-0.14045500755310059,
0.10863416641950607,
-0.01538749597966671,
0.2205606997013092,
-0.05276969447731972,
0.08474689722061157,
-0.10045039653778076,
0.0030265748500823975,
0.1505068987607956,
-0.13235478103160858,
-0.13257305324077606,
0.17562732100486755,
0.010892693884670734,
-0.12102805823087692,
0.11463963240385056,
0.23453564941883087,
-0.04864249378442764,
0.039647992700338364,
-0.12790021300315857,
-0.027227716520428658,
-0.09898802638053894,
-0.0401567779481411,
0.09826990962028503,
-0.039674896746873856,
0.0911707952618599,
-0.22631122171878815,
0.15506352484226227,
0.09883806854486465,
-0.07681833952665329,
0.05592617392539978,
-0.04476223886013031,
-0.10862582921981812,
-0.21020174026489258,
0.14912256598472595,
-0.1239362359046936,
-0.15930962562561035,
-0.037727635353803635,
-0.1960614174604416,
-0.11886157840490341,
-0.12068779021501541,
0.044304244220256805,
-0.21429681777954102,
-0.0027671135030686855,
-0.2790626287460327,
0.05374142900109291,
0.0620003342628479,
0.1587194800376892,
0.008378039114177227,
-0.12029215693473816,
0.012598086148500443,
-0.01724798046052456,
0.13439875841140747,
0.00936198327690363,
0.05884300172328949,
-0.04723082110285759,
-0.11504088342189789,
0.10439908504486084,
-0.1680718958377838,
-0.3491111695766449,
-0.12336674332618713,
0.08378750830888748,
0.00014838170318398625,
-0.25897863507270813,
-0.07148754596710205,
-0.2980717122554779,
0.025415945798158646,
0.012076115235686302,
0.030297501012682915,
-0.0206491369754076,
0.2120949625968933,
0.0009260238730348647,
0.06269951909780502,
-0.0992649719119072,
0.02412218041718006,
0.035464122891426086,
0.041154421865940094,
-0.29421937465667725,
0.2075791358947754,
-0.35105496644973755,
0.10156290978193283,
-0.0008534162188880146,
0.3578691780567169,
0.23701776564121246,
0.10991940647363663,
-0.07804904878139496,
0.05236705765128136,
-0.1955796778202057,
0.13656695187091827,
-0.3135285973548889,
-0.08378083258867264,
0.05527883768081665,
0.2654303312301636,
0.061546482145786285,
0.13230787217617035,
0.01156462449580431,
0.019084813073277473,
0.13614583015441895,
0.18726004660129547,
-0.09580893814563751,
0.17441196739673615,
-0.06263088434934616,
0.2469918578863144,
0.15185901522636414,
0.22539368271827698,
-0.049367956817150116,
-0.14969949424266815,
0.10304896533489227,
-0.10338637232780457,
-0.21701015532016754,
0.0873708575963974,
0.04338284581899643,
0.05111835524439812,
0.236829936504364,
0.1168406680226326,
0.037088532000780106,
-0.16237536072731018,
-0.1892654150724411,
0.1218801736831665,
0.10365858674049377,
-0.17739388346672058,
0.152692049741745,
-0.40336209535598755,
0.05044204741716385,
-0.0393596813082695,
0.1683708280324936,
-0.2035173922777176,
0.11442647874355316,
-0.287390798330307,
-0.06974375247955322,
-0.04308752715587616,
-0.20181424915790558,
0.014996395446360111,
-0.06252769380807877,
-0.1074119582772255,
0.24479013681411743,
0.35040968656539917,
-0.13128724694252014,
0.05102018639445305,
-0.11125431209802628,
0.18899142742156982,
0.03821948915719986,
-0.09817461669445038,
0.18514886498451233,
0.08732877671718597,
-0.13764266669750214,
-0.15228471159934998,
0.22488656640052795,
0.167885884642601,
-0.07653719186782837,
0.07161588966846466,
-0.24121344089508057,
-0.22544607520103455,
-0.003177613951265812,
-0.0874536782503128,
0.09331514686346054,
0.09090444445610046,
0.09747285395860672,
0.12344249337911606,
0.1523764580488205,
-0.07381744682788849,
0.32409629225730896,
-0.026662545278668404,
-0.4061793386936188,
-0.0364595428109169,
-0.04968196898698807,
0.21240730583667755,
0.1434352993965149,
0.02098614163696766,
-0.05016905069351196,
0.242689847946167,
-0.3591812252998352,
0.001447342918254435,
-0.10946210473775864,
0.16868111491203308,
0.1377994269132614,
0.08011902123689651,
0.05098829045891762,
0.5040382742881775,
-0.16110262274742126,
-0.33666807413101196,
-0.20837557315826416,
-0.11419766396284103,
0.18526142835617065,
0.11859056353569031,
0.1811191886663437,
-0.07485385239124298,
-0.12946468591690063,
0.1338350772857666,
-0.2288673371076584,
0.09148934483528137,
-0.06151926890015602,
-0.022835809737443924,
-0.12620426714420319,
-0.048783544450998306,
0.13344287872314453,
0.030537376180291176,
0.15277422964572906,
-0.02912874147295952,
0.1835312396287918,
-0.10834959149360657,
-0.1728462278842926,
0.031088896095752716,
-0.06576745212078094,
0.1199847012758255,
-0.04446310177445412,
-0.06445121765136719,
0.021897809579968452,
-0.08409357070922852,
0.09952908009290695,
0.15926285088062286,
-0.14487500488758087,
-0.07691316306591034,
0.04399576410651207,
-0.3102682828903198,
0.1735782027244568,
-0.15741389989852905,
0.07837500423192978,
0.11716334521770477,
-0.08240988850593567,
-0.06934623420238495,
-0.19559966027736664,
0.03178928419947624,
0.12733109295368195,
0.13712456822395325,
-0.11874246597290039,
-0.07138562947511673,
0.13357000052928925,
-0.06502669304609299,
-0.18473656475543976,
-0.11502155661582947,
-0.1073806881904602,
0.2112463265657425,
0.19232220947742462,
0.01626606471836567,
0.14365966618061066,
0.025647884234786034,
0.08814996480941772,
-0.06729831546545029,
-0.2279045134782791,
-0.025414593517780304,
0.012830589897930622,
-0.06989514827728271,
0.11339975893497467,
-0.06449582427740097,
0.13761834800243378,
-0.10747107863426208,
0.052418455481529236,
-0.033324602991342545,
0.10171476751565933
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. what is reported for unaffected infants . Increased frequency of miscarriages of affected fetuses is possible .Neonatal onset PA. A typical presentation of PA in the neonatal period is characterized by a healthy newborn with poor feeding and decreased arousal in the first few days of life, followed by progressive encephalopathy of unexplained origin. Without prompt diagnosis and management, neonates can develop progressive encephalopathy manifesting as lethargy, seizures, or coma that can result in death (see Table 2). Most individuals eventually diagnosed with PA become symptomatic in the first weeks of life, with 50%-60% exhibiting clinical signs at the time of the newborn screen report .Table 2. Features of Neonatal-Onset Propionic AcidemiaView in own windowClinical FeaturesLaboratory FindingsPoor feedingVomitingIrritabilityLethargyProgressive encephalopathySeizuresComaRespiratory failureHigh anion-gap metabolic acidosisKetonuriaHyperammonemia (>90%)HypoglycemiaEle | [
-0.08785457164049149,
0.05781324952840805,
-0.1120687797665596,
-0.18334823846817017,
0.048023879528045654,
-0.015009051188826561,
-0.009272759780287743,
-0.21713683009147644,
-0.06522582471370697,
-0.0881020799279213,
0.06263955682516098,
0.03262406960129738,
0.07516095042228699,
0.07047785818576813,
-0.24692338705062866,
0.11537770926952362,
0.08561953157186508,
0.03210654482245445,
-0.19866250455379486,
-0.1377696394920349,
0.12727317214012146,
-0.23342449963092804,
-0.025898097082972527,
0.18721897900104523,
0.24790328741073608,
-0.12368430942296982,
0.23243825137615204,
-0.29443156719207764,
0.23187372088432312,
0.1318735033273697,
-0.025099612772464752,
0.21073994040489197,
0.025155888870358467,
-0.37031081318855286,
-0.12206718325614929,
-0.07999829947948456,
0.048985645174980164,
-0.14832226932048798,
0.027441443875432014,
-0.257026731967926,
0.16461975872516632,
-0.13637107610702515,
0.23225446045398712,
-0.1013733521103859,
0.2000974863767624,
-0.09082036465406418,
-0.09568288922309875,
-0.06856899708509445,
-0.09000431001186371,
0.26745712757110596,
0.21543778479099274,
-0.010832511819899082,
-0.2908064126968384,
0.015218080952763557,
0.19477729499340057,
-0.23480230569839478,
-0.022131972014904022,
0.004578550346195698,
-0.15886998176574707,
0.20145103335380554,
0.05602044239640236,
-0.20258593559265137,
-0.09573862701654434,
-0.2588932514190674,
0.057951267808675766,
-0.11493173986673355,
-0.10204493254423141,
0.1622960865497589,
0.16923721134662628,
-0.21917279064655304,
0.09112819284200668,
0.01659410074353218,
-0.05717363581061363,
0.08296654373407364,
-0.10211995989084244,
0.03758133947849274,
0.07856627553701401,
0.1331004947423935,
-0.1521683931350708,
-0.3178637623786926,
-0.20693115890026093,
-0.03663754463195801,
0.07892093807458878,
-0.06641454994678497,
-0.04849778488278389,
0.028464460745453835,
0.2637167274951935,
0.05784410238265991,
-0.005113631021231413,
0.21384187042713165,
0.15071937441825867,
0.0007391886902041733,
-0.048879045993089676,
-0.11566386371850967,
0.14096178114414215,
-0.08992531895637512,
0.14782561361789703,
-0.016999727115035057,
-0.24036017060279846,
0.030910314992070198,
0.11511129140853882,
0.04940513148903847,
0.0008786625694483519,
0.09004295617341995,
-0.06293627619743347,
0.17032749950885773,
-0.08390342444181442,
-0.028911791741847992,
-0.0275712963193655,
0.0444086492061615,
0.04309573397040367,
-0.23853540420532227,
0.21848520636558533,
-0.002058199141174555,
-0.4908386468887329,
-0.09398135542869568,
-0.19691213965415955,
0.2543155550956726,
-0.058594487607479095,
0.09263673424720764,
-0.044854823499917984,
0.12956468760967255,
0.10753893852233887,
-0.0928301215171814,
-0.14810630679130554,
0.06738854944705963,
0.047917440533638,
0.06295638531446457,
0.2648457884788513,
-0.11814619600772858,
-0.031558066606521606,
-0.0920940488576889,
0.011843075975775719,
-0.04177997261285782,
0.2802804708480835,
-0.03490110859274864,
-0.2602982223033905,
-0.2837650775909424,
-0.030868245288729668,
-0.05792229622602463,
0.14015087485313416,
0.1993657350540161,
0.2437582015991211,
0.06778909265995026,
0.24868729710578918,
0.03183611109852791,
0.3599490225315094,
-0.043287962675094604,
0.2185351550579071,
-0.03504238277673721,
-0.10076720267534256,
-0.19324295222759247,
0.254845529794693,
0.08587247133255005,
-0.017675083130598068,
0.2525285482406616,
0.11997593939304352,
0.2591373026371002,
-0.05392647534608841,
0.1739136427640915,
-0.0975995659828186,
0.014305762946605682,
-0.023587550967931747,
0.060047540813684464,
-0.18165722489356995,
-0.07223564386367798,
-0.5416679382324219,
-0.044283993542194366,
-0.13663619756698608,
-0.13351213932037354,
-0.08276144415140152,
-0.0028591942973434925,
-0.06697811931371689,
0.07064606249332428,
-0.014869775623083115,
0.03579613193869591,
-0.23035505414009094,
-0.0556938536465168,
0.011768939904868603,
0.18620091676712036,
0.1310640424489975,
-0.034109219908714294,
-0.22824953496456146,
0.06726115942001343,
-0.11039657890796661,
-0.15692797303199768,
0.19124771654605865,
0.25793787837028503,
-0.029059424996376038,
0.1710744947195053,
0.18523642420768738,
0.08179773390293121,
-0.03943134844303131,
0.09804577380418777,
-0.01578296348452568,
-0.1988091915845871,
0.22384034097194672,
0.007886131294071674,
-0.042142726480960846,
0.07777448743581772,
-0.16495196521282196,
-0.0811547338962555,
0.17423610389232635,
-0.18049032986164093,
-0.03545831888914108,
-0.1749296486377716,
0.07240444421768188,
-0.08426370471715927,
0.000085578350990545,
0.05637560039758682,
-0.1333664506673813,
0.33203476667404175,
-0.15127043426036835,
-0.03557147830724716,
-0.23779161274433136,
-0.09691302478313446,
0.14315444231033325,
-0.04277178272604942,
0.04210061579942703,
0.13236066699028015,
-0.07093273848295212,
0.024757688865065575,
-0.007290832698345184,
-0.17293322086334229,
-0.08721495419740677,
0.03912976384162903,
-0.4399075210094452,
-0.2493366152048111,
0.22667299211025238,
-0.2986477315425873,
-0.14597256481647491,
0.07577525079250336,
-0.04498080536723137,
0.15077653527259827,
-0.005973287392407656,
-0.09804387390613556,
-0.14846502244472504,
0.35740095376968384,
-0.2388225495815277,
0.01924770511686802,
-0.47921982407569885,
-0.13320639729499817,
-0.00834529660642147,
0.09229766577482224,
-0.053120359778404236,
0.04633304104208946,
-0.08340559899806976,
-0.04941614344716072,
0.12087634950876236,
0.05012023448944092,
-0.004800115711987019,
0.0940876230597496,
0.033435918390750885,
0.018776021897792816,
-0.2715030014514923,
-0.12763391435146332,
0.14086942374706268,
0.0024971221573650837,
0.09099029004573822,
0.025013333186507225,
-0.11107038706541061,
0.31453755497932434,
-0.029356565326452255,
0.05308876931667328,
0.21796388924121857,
-0.08251385390758514,
-0.14617379009723663,
0.13390327990055084,
-0.059000805020332336,
-0.3000127971172333,
-0.11989200860261917,
0.24325154721736908,
0.06429382413625717,
0.10305269062519073,
-0.22533690929412842,
-0.19379013776779175,
0.0946815013885498,
0.1275915950536728,
-0.018017223104834557,
-0.12346604466438293,
-0.15371929109096527,
0.1870189756155014,
-0.023824594914913177,
-0.08029652386903763,
0.20269033312797546,
0.10951893776655197,
0.0721382349729538,
0.06699087470769882,
-0.07256963849067688,
0.12759919464588165,
-0.04364899918437004,
0.14945828914642334,
-0.2024340033531189,
-0.08395501226186752,
0.15679344534873962,
0.25443771481513977,
0.025877637788653374,
0.1546725034713745,
0.024469316005706787,
0.13074307143688202,
0.09223951399326324,
0.15499205887317657,
0.1694849282503128,
-0.046983491629362106,
-0.2724514305591583,
-0.03998253867030144,
-0.08037770539522171,
-0.1358264982700348,
0.22843018174171448,
0.21044689416885376,
-0.07795965671539307,
-0.09895845502614975,
-0.20239704847335815,
0.03786829859018326,
-0.1320066750049591,
-0.04646255448460579,
0.009261000901460648,
0.16901522874832153,
0.19796279072761536,
0.22590655088424683,
0.007600584998726845,
0.07203024625778198,
-0.006131522823125124,
0.07666987925767899,
-0.2559405267238617,
-0.1083202138543129,
0.036352697759866714,
0.03146911412477493,
-0.11861153692007065,
0.16548173129558563,
0.01758469082415104,
0.14539951086044312,
0.0041273352690041065,
-0.23608490824699402,
0.3327687382698059,
-0.227611243724823,
0.29054591059684753,
-0.05540316179394722,
-0.14188341796398163,
0.04970278963446617,
0.15774475038051605,
-0.36018648743629456,
-0.006569743622094393,
-0.24133598804473877,
-0.24860186874866486,
-0.006700577214360237,
-0.12298876792192459,
0.19233278930187225,
0.04149485006928444,
0.0603734590113163,
-0.17363397777080536,
0.0750979632139206,
-0.20487868785858154,
-0.21746310591697693,
0.07268974184989929,
-0.1557239145040512,
-0.029960602521896362,
0.07813692837953568,
0.10711585730314255,
0.12092980742454529,
-0.24224479496479034,
0.02588372491300106,
0.07441390305757523,
-0.17543135583400726,
0.05070070922374725,
-0.2380218207836151,
0.07273925840854645,
-0.08481147885322571,
0.1652665138244629,
0.004834451712667942,
0.10085100680589676,
0.14532795548439026,
0.03508191928267479,
0.12056954950094223,
-0.1467520147562027,
0.1990327686071396,
-0.06205637380480766,
0.09992470592260361,
-0.2554650604724884,
-0.16879485547542572,
0.19760458171367645,
0.07844304293394089,
0.16945797204971313,
0.010950912721455097,
0.007003697566688061,
0.10968136042356491,
-0.06942207366228104,
0.27546361088752747,
0.28438469767570496,
-0.39749380946159363,
0.08722023665904999,
0.07838409394025803,
-0.06904838979244232,
0.16121311485767365,
0.12086760252714157,
0.07525317370891571,
-0.07756329327821732,
0.12229269742965698,
-0.09183790534734726,
0.04885268583893776,
-0.042507752776145935,
-0.09215173125267029,
0.06013981252908707,
0.10186488926410675,
0.0004979203222319484,
0.16475559771060944,
0.09115973860025406,
0.11795758455991745,
-0.199043869972229,
0.010030457749962807,
0.011969190090894699,
-0.14450368285179138,
0.02865828573703766,
-0.27212464809417725,
-0.1907840073108673,
-0.03864248842000961,
-0.03166636824607849,
0.0066534108482301235,
0.04599178209900856,
-0.02705882303416729,
0.06043064594268799,
-0.060246869921684265,
0.08970794081687927,
-0.06369870156049728,
-0.05298426002264023,
0.005005677696317434,
0.11552146077156067,
-0.0437907911837101,
0.07005243748426437,
0.16282738745212555,
0.24860870838165283,
-0.1168275997042656,
-0.058953359723091125,
0.0020528093446046114,
0.03965502232313156,
0.06988848745822906,
-0.14196744561195374,
0.07541664689779282,
-0.18679063022136688,
-0.15861044824123383,
0.08344371616840363,
0.14227400720119476,
-0.0988321304321289,
0.05179460346698761,
-0.2509191632270813,
0.26889729499816895,
0.2658919394016266,
0.06684631109237671,
0.03306678682565689,
0.18930134177207947,
0.12598317861557007,
-0.0841679647564888,
-0.07022754102945328,
0.09736375510692596,
0.07872121036052704,
0.07837556302547455,
0.022037765011191368,
-0.0328240841627121,
0.11881915479898453,
-0.005380002781748772,
-0.06867168098688126,
0.1993406116962433,
0.15463370084762573,
-0.17358249425888062,
-0.2556479573249817,
0.012833304703235626,
-0.03494412079453468,
0.11121181398630142,
0.05767744034528732,
-0.06817276775836945,
0.037025511264801025,
0.048902980983257294,
-0.0622636154294014,
0.01710139587521553,
-0.12393052875995636,
-0.10404051095247269,
-0.07686078548431396,
-0.09676158428192139,
0.023563947528600693,
0.023452259600162506,
0.038449905812740326,
-0.13446761667728424,
0.16324123740196228,
-0.07417739927768707,
-0.08560536056756973,
0.11858940124511719,
-0.3093467056751251,
-0.011950662359595299,
0.3352499306201935,
0.057236697524785995,
0.021516038104891777,
0.01277990359812975,
0.00939291249960661,
0.2641292214393616,
-0.019509870558977127,
-0.24145236611366272,
-0.06997349113225937,
-0.0289542805403471,
-0.015688501298427582,
0.09247730672359467,
-0.09223385155200958,
-0.039407532662153244,
-0.046323589980602264,
0.03962370753288269,
-0.07663285732269287,
-0.02425452508032322,
-0.12742485105991364,
-0.14500750601291656,
-0.021567894145846367,
0.16199347376823425,
0.0938904881477356,
0.19066518545150757,
-0.06626099348068237,
-0.04956546425819397,
0.16168393194675446,
-0.28999650478363037,
0.1799558848142624,
0.3581670820713043,
0.05042915418744087,
-0.17089560627937317,
0.15081802010536194,
-0.030763164162635803,
0.19471874833106995,
-0.03555775433778763,
0.12485503405332565,
-0.12734778225421906,
-0.00037737676757387817,
0.17476145923137665,
-0.06728647649288177,
-0.05085378140211105,
0.19519877433776855,
-0.037502139806747437,
-0.1202922835946083,
0.15594512224197388,
0.19523613154888153,
-0.03293617069721222,
0.057119835168123245,
-0.12101966887712479,
0.034966032952070236,
-0.11221464723348618,
-0.0104055255651474,
0.08391905575990677,
0.01670762151479721,
0.0334804505109787,
-0.2379135936498642,
0.2609159052371979,
0.1366318315267563,
0.01132200751453638,
0.08635777235031128,
-0.006834115367382765,
-0.11622639000415802,
-0.21867066621780396,
0.10670197010040283,
-0.05861135944724083,
-0.14803002774715424,
-0.031526125967502594,
-0.19104087352752686,
-0.16300944983959198,
-0.21155688166618347,
-0.009559360332787037,
-0.19081664085388184,
0.02723311074078083,
-0.2234487235546112,
0.025864247232675552,
0.0010100252693518996,
0.14756059646606445,
-0.007074778899550438,
-0.1396210491657257,
-0.0350797176361084,
-0.06391122937202454,
0.04924285411834717,
-0.08444488793611526,
0.09087070822715759,
0.0021096128039062023,
-0.07772114127874374,
-0.052410904318094254,
-0.09326035529375076,
-0.3446047008037567,
-0.0737156793475151,
0.09645572304725647,
0.05036560073494911,
-0.2720251977443695,
-0.11211491376161575,
-0.2441629022359848,
0.03763430938124657,
-0.05311038717627525,
0.09469065815210342,
0.014782763086259365,
0.3205196261405945,
0.004802123177796602,
0.022612635046243668,
-0.10797389596700668,
0.09584233164787292,
0.10470417141914368,
0.11263394355773926,
-0.1995501071214676,
0.22811342775821686,
-0.2819441854953766,
0.20858779549598694,
0.04894472286105156,
0.40299054980278015,
0.20722860097885132,
0.1511421948671341,
-0.11591385304927826,
0.019694136455655098,
-0.10740415751934052,
0.17040175199508667,
-0.28656429052352905,
-0.10790011286735535,
0.13647013902664185,
0.2700912058353424,
0.0615062415599823,
0.12715505063533783,
0.06996521353721619,
-0.06325259059667587,
0.11930255591869354,
0.2569061815738678,
0.009517639875411987,
0.044230006635189056,
-0.015730172395706177,
0.14342951774597168,
0.029351405799388885,
0.1546909511089325,
-0.09938213229179382,
-0.11907285451889038,
0.07594363391399384,
-0.07869512587785721,
-0.2196749895811081,
0.1061491072177887,
-0.0031381789594888687,
0.05361303687095642,
0.2104215919971466,
0.08986405283212662,
-0.04040156304836273,
-0.14907845854759216,
-0.1337917447090149,
0.0980725958943367,
0.055517442524433136,
-0.21593385934829712,
0.20701813697814941,
-0.33147329092025757,
0.09440352022647858,
-0.03480534628033638,
0.14336572587490082,
-0.3126094937324524,
0.174589604139328,
-0.2858505845069885,
-0.036784376949071884,
0.018333477899432182,
-0.25650230050086975,
0.021658021956682205,
-0.07256081700325012,
0.01565701514482498,
0.2006688266992569,
0.31653082370758057,
-0.15920192003250122,
-0.051821269094944,
-0.16348832845687866,
0.13531386852264404,
-0.044743310660123825,
-0.0781429186463356,
0.1660211682319641,
0.1524733453989029,
-0.19341276586055756,
-0.20037975907325745,
0.23406527936458588,
0.0910978689789772,
-0.07104058563709259,
0.03607034310698509,
-0.26625481247901917,
-0.21222954988479614,
-0.019909188151359558,
-0.00894968118518591,
0.09860092401504517,
0.009585512802004814,
0.12770138680934906,
0.100845105946064,
0.13729457557201385,
-0.058024365454912186,
0.3791060149669647,
0.01646985299885273,
-0.370680570602417,
-0.08560517430305481,
0.08805513381958008,
0.23361584544181824,
0.08564484119415283,
0.01721176505088806,
-0.06539851427078247,
0.31413236260414124,
-0.40131819248199463,
0.0823262557387352,
-0.1093580573797226,
0.1838398426771164,
0.05511045455932617,
0.08235906064510345,
0.11420322209596634,
0.603491485118866,
-0.10640033334493637,
-0.36303621530532837,
-0.20527461171150208,
-0.17378082871437073,
0.14748427271842957,
0.20316506922245026,
0.1345377266407013,
-0.016931142657995224,
-0.22370800375938416,
0.16733534634113312,
-0.20271873474121094,
0.07113314419984818,
-0.10062002390623093,
-0.06742677092552185,
-0.1715896874666214,
-0.003150867996737361,
0.14146392047405243,
0.047319408506155014,
0.1369040161371231,
-0.07988274097442627,
0.22732841968536377,
-0.10475357621908188,
-0.0924239233136177,
0.028696317225694656,
-0.16995593905448914,
0.14894381165504456,
-0.0006708880537189543,
0.0005762450746260583,
0.05122683569788933,
-0.0624670572578907,
-0.04100324586033821,
0.16311237215995789,
-0.13353265821933746,
-0.10786185413599014,
0.039399389177560806,
-0.3076607882976532,
0.11586355417966843,
-0.205789715051651,
0.08525178581476212,
0.062200628221035004,
-0.06622955203056335,
-0.12783056497573853,
-0.14689521491527557,
-0.028254680335521698,
0.21251139044761658,
0.0762653574347496,
-0.08623430132865906,
-0.09052521735429764,
0.1745317131280899,
-0.03250483423471451,
-0.12840530276298523,
-0.13107402622699738,
-0.1333392858505249,
0.2251778393983841,
0.12610222399234772,
-0.050728779286146164,
0.16020196676254272,
0.04829002916812897,
0.06883494555950165,
-0.05641256645321846,
-0.22362777590751648,
-0.07318830490112305,
-0.03378768637776375,
-0.14882589876651764,
0.06095048412680626,
-0.03041323460638523,
0.15360680222511292,
-0.15265321731567383,
0.1148621067404747,
0.021491320803761482,
0.10382292419672012
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. diagnosed with PA become symptomatic in the first weeks of life, with 50%-60% exhibiting clinical signs at the time of the newborn screen report .Table 2. Features of Neonatal-Onset Propionic AcidemiaView in own windowClinical FeaturesLaboratory FindingsPoor feedingVomitingIrritabilityLethargyProgressive encephalopathySeizuresComaRespiratory failureHigh anion-gap metabolic acidosisKetonuriaHyperammonemia (>90%)HypoglycemiaElevated 3-OH propionic acid & methylcitric acidHyperglycinemiaElevated propionylcarnitineAnemiaLeukopeniaThrombocytopeniaSee Table 3a (pdf) for a summary of the prevalence of major clinical findings during metabolic crisis in propionic acidemia.Following initial clinical and biochemical stabilization, individuals with neonatal-onset PA may develop a range of symptoms affecting different organ systems. See following and Table 3b (pdf).Late-onset PA. | [
-0.053285229951143265,
0.09142565727233887,
-0.12411288917064667,
-0.2508509159088135,
0.03912659361958504,
0.055847715586423874,
0.04524802416563034,
-0.18998225033283234,
-0.10559408366680145,
-0.11983716487884521,
0.10347525030374527,
0.08292700350284576,
0.04897496476769447,
0.10908317565917969,
-0.24095889925956726,
0.13538064062595367,
0.2056981325149536,
0.00789601169526577,
-0.07176190614700317,
-0.13844287395477295,
0.048011574894189835,
-0.14038671553134918,
-0.050575364381074905,
0.16030219197273254,
0.21663707494735718,
-0.1572994738817215,
0.1691378504037857,
-0.27584412693977356,
0.15622422099113464,
0.08064118027687073,
0.03777245432138443,
0.08813406527042389,
0.120298370718956,
-0.2758210599422455,
-0.09358462691307068,
-0.11683233827352524,
-0.061027731746435165,
-0.12016932666301727,
0.010607545264065266,
-0.20773564279079437,
0.2100542038679123,
-0.1419616937637329,
0.29966863989830017,
0.02871699258685112,
0.17393559217453003,
-0.06920575350522995,
-0.053198229521512985,
-0.051786329597234726,
-0.024501902982592583,
0.2389066070318222,
0.24285997450351715,
-0.08660050481557846,
-0.25007516145706177,
-0.01371231023222208,
0.2216135412454605,
-0.2828734815120697,
-0.08379864692687988,
-0.03717898577451706,
-0.13964442908763885,
0.07940651476383209,
0.030017774552106857,
-0.12732122838497162,
-0.04795420542359352,
-0.21697930991649628,
0.1810677945613861,
-0.1539868265390396,
-0.08859261870384216,
0.04766639694571495,
0.09669293463230133,
-0.13965438306331635,
0.11311164498329163,
-0.005029432009905577,
-0.034990958869457245,
0.04306360334157944,
-0.14132477343082428,
0.06696068495512009,
0.04152273014187813,
-0.027020256966352463,
-0.03823499381542206,
-0.3556353747844696,
-0.17796769738197327,
-0.010660923086106777,
0.10255053639411926,
-0.08470102399587631,
-0.05477782338857651,
0.03998466208577156,
0.18415461480617523,
0.060450609773397446,
-0.10369700938463211,
0.25756025314331055,
0.11538064479827881,
0.03552031144499779,
-0.08780065178871155,
-0.07376633584499359,
0.18231864273548126,
-0.15471531450748444,
0.10451819747686386,
0.0938534066081047,
-0.220915287733078,
0.06023138016462326,
0.07076062262058258,
0.10029670596122742,
-0.17043620347976685,
-0.019291037693619728,
-0.020207151770591736,
0.10977771133184433,
-0.07310785353183746,
-0.08309698104858398,
-0.008405500091612339,
0.029027853161096573,
0.08497960865497589,
-0.16360841691493988,
0.21182644367218018,
0.0333477258682251,
-0.5242189168930054,
-0.1166403666138649,
-0.17342741787433624,
0.20936934649944305,
-0.0317511260509491,
0.06019175425171852,
0.025825055316090584,
0.10019318759441376,
0.054136842489242554,
-0.06437359005212784,
-0.09964850544929504,
0.08332022279500961,
-0.021786216646432877,
0.034195736050605774,
0.15770967304706573,
-0.09853356331586838,
0.0843854621052742,
0.09346551448106766,
0.04836830869317055,
-0.10998369008302689,
0.16245992481708527,
-0.05291337892413139,
-0.17317309975624084,
-0.2906399369239807,
-0.12100028246641159,
0.03460102528333664,
0.1293330192565918,
0.21524456143379211,
0.22334787249565125,
0.10251864790916443,
0.17916841804981232,
0.05397476628422737,
0.4124743938446045,
-0.11468011885881424,
0.1117488369345665,
0.05169782042503357,
-0.07610063254833221,
-0.319322794675827,
0.22444988787174225,
0.008356289006769657,
-0.0508316233754158,
0.11643468588590622,
0.07169748842716217,
0.19907036423683167,
-0.08592532575130463,
0.16030487418174744,
-0.008214759640395641,
-0.00521076051518321,
-0.018353475257754326,
-0.02636166475713253,
-0.15774449706077576,
0.026874013245105743,
-0.4637603163719177,
-0.012393506243824959,
-0.14337030053138733,
-0.09065067768096924,
-0.05407145246863365,
-0.027582457289099693,
0.021078355610370636,
0.13017390668392181,
0.12267811596393585,
0.04110807552933693,
-0.23767244815826416,
-0.05710192769765854,
0.005978665314614773,
0.20287705957889557,
0.1719287633895874,
0.033595699816942215,
-0.20507404208183289,
-0.02781418152153492,
-0.1901044100522995,
-0.10516641288995743,
0.16175217926502228,
0.14110629260540009,
-0.0411214753985405,
0.19267357885837555,
0.1918758898973465,
-0.054621532559394836,
0.03807305544614792,
0.08696155250072479,
0.055198848247528076,
-0.21431012451648712,
0.08463683724403381,
-0.03267113119363785,
-0.06415802985429764,
0.01015020813792944,
-0.127025306224823,
-0.06995216012001038,
0.09202113747596741,
-0.11510056257247925,
0.012123435735702515,
-0.1391008496284485,
0.08303041011095047,
-0.06466349214315414,
0.11121475696563721,
0.10373227298259735,
-0.15381373465061188,
0.27594149112701416,
-0.23726941645145416,
0.008435626514256,
-0.23486953973770142,
-0.09080638736486435,
0.047294195741415024,
-0.08828572928905487,
0.04448425769805908,
0.11552984267473221,
-0.027165835723280907,
0.03204509615898132,
0.08689901232719421,
-0.206059992313385,
-0.08502727746963501,
-0.04693206027150154,
-0.36600953340530396,
-0.14355763792991638,
0.19923515617847443,
-0.26911741495132446,
-0.11852706223726273,
0.08065076917409897,
0.004949148744344711,
0.15294604003429413,
-0.1390705108642578,
-0.13619773089885712,
-0.18653962016105652,
0.2513117790222168,
-0.16066378355026245,
0.016791878268122673,
-0.36653590202331543,
0.03948349133133888,
0.020970800891518593,
0.04782184585928917,
-0.005951070226728916,
0.09677984565496445,
-0.11438111215829849,
-0.03952345997095108,
0.024284953251481056,
0.18813489377498627,
-0.023982686921954155,
0.09169366210699081,
0.013834591023623943,
-0.009810617193579674,
-0.22741074860095978,
-0.16928435862064362,
0.07529352605342865,
-0.043758343905210495,
0.09576669335365295,
0.05102560669183731,
-0.1784922480583191,
0.14163166284561157,
0.03639739379286766,
0.006352726835757494,
0.01636485569179058,
-0.09884271770715714,
-0.23214741051197052,
0.09352441877126694,
-0.1284847855567932,
-0.2424846589565277,
-0.10326584428548813,
0.20167626440525055,
0.07400502264499664,
0.0881308764219284,
-0.23172993957996368,
-0.09889037162065506,
0.03704339265823364,
0.15448366105556488,
-0.06226447969675064,
0.01155113335698843,
-0.1717015653848648,
0.20618936419487,
-0.029247714206576347,
-0.07505107671022415,
0.23773707449436188,
0.0508464090526104,
-0.028163118287920952,
0.07656507939100266,
-0.04018626734614372,
0.06694207340478897,
0.00029694201657548547,
0.11891107261180878,
-0.0607064813375473,
0.041923560202121735,
0.11935804039239883,
0.2346273809671402,
0.003785795299336314,
0.06227259710431099,
0.011770226061344147,
0.18514657020568848,
0.14557361602783203,
0.16227559745311737,
0.11731745302677155,
-0.09758570790290833,
-0.25495535135269165,
-0.11446695774793625,
-0.07381023466587067,
-0.14456619322299957,
0.2680811882019043,
0.12158013135194778,
-0.13813893496990204,
-0.1667093187570572,
-0.16598542034626007,
0.06767870485782623,
-0.12847119569778442,
-0.12422940135002136,
-0.04131132736802101,
0.14279139041900635,
0.18837757408618927,
0.17625363171100616,
0.03612222522497177,
0.062189675867557526,
0.06516503542661667,
0.11975830793380737,
-0.1794998198747635,
-0.12687210738658905,
-0.02492881752550602,
0.044484756886959076,
-0.1057736873626709,
0.1790817677974701,
0.10720270127058029,
0.07487665116786957,
0.03085491806268692,
-0.12728631496429443,
0.36421725153923035,
-0.1474301517009735,
0.27247124910354614,
-0.06887820363044739,
-0.09496480226516724,
0.04458678886294365,
0.23709917068481445,
-0.44162487983703613,
0.0001510522561147809,
-0.18478037416934967,
-0.19308346509933472,
-0.05514618754386902,
-0.07011254131793976,
0.11877454072237015,
0.16076552867889404,
0.016750888898968697,
-0.10018419474363327,
-0.004503106698393822,
-0.008065040223300457,
-0.18631215393543243,
0.15906953811645508,
-0.13576965034008026,
-0.038874972611665726,
0.04982100799679756,
0.08899212628602982,
0.12953023612499237,
-0.2568071186542511,
0.03242063522338867,
0.023644518107175827,
-0.15613225102424622,
0.14186061918735504,
-0.1514333337545395,
-0.03979537636041641,
-0.0012378654209896922,
0.15766198933124542,
0.023587597534060478,
0.19074831902980804,
0.08844201266765594,
0.03194297105073929,
0.1387331783771515,
-0.04987533017992973,
0.14333677291870117,
-0.002536649350076914,
0.07573582231998444,
-0.3738446533679962,
-0.21246391534805298,
0.23184889554977417,
0.07244371622800827,
0.1524517983198166,
0.05857636034488678,
0.07065445184707642,
0.13160917162895203,
-0.12514497339725494,
0.12840312719345093,
0.18596409261226654,
-0.33655813336372375,
0.06422191858291626,
0.06760186702013016,
-0.0560007281601429,
0.1037231981754303,
0.10657241940498352,
0.08419284969568253,
-0.07042130082845688,
0.11368298530578613,
-0.0959976390004158,
-0.022159496322274208,
-0.06936291605234146,
-0.08117810636758804,
0.10995521396398544,
0.15607774257659912,
0.046616990119218826,
0.2174631953239441,
-0.04008566960692406,
0.17005954682826996,
-0.11618661135435104,
0.05178717523813248,
0.0005976308602839708,
-0.08988197147846222,
-0.04475155472755432,
-0.27378082275390625,
-0.1445855349302292,
-0.03051058016717434,
-0.07968247681856155,
-0.01447633933275938,
0.029158147051930428,
0.059170596301555634,
0.059670183807611465,
-0.004994480405002832,
0.05664557218551636,
-0.1177242249250412,
-0.13960881531238556,
-0.016392918303608894,
0.16132746636867523,
-0.014212517999112606,
0.1006031408905983,
0.1784479022026062,
0.25449326634407043,
-0.009402385912835598,
-0.07262036204338074,
0.0026867715641856194,
0.025208909064531326,
0.0055442554876208305,
-0.2523442506790161,
0.1414085179567337,
-0.09625586867332458,
-0.17292901873588562,
0.12209488451480865,
0.08036436885595322,
-0.0743250846862793,
0.03343743085861206,
-0.2477721869945526,
0.15903861820697784,
0.19639699161052704,
0.12364044785499573,
0.08140118420124054,
0.21667233109474182,
0.12280841171741486,
-0.08915623277425766,
-0.08189147710800171,
0.02948959916830063,
0.06611853837966919,
0.09223471581935883,
0.08397524058818817,
-0.14759020507335663,
0.10920608788728714,
0.0362018421292305,
-0.13647256791591644,
0.22890333831310272,
0.16097460687160492,
-0.0811501145362854,
-0.22939881682395935,
0.08338195085525513,
-0.12489575147628784,
0.07803057134151459,
0.08280348032712936,
0.11123059689998627,
0.055237796157598495,
0.09606391936540604,
-0.026892801746726036,
0.03837424889206886,
-0.1611311286687851,
-0.06952328979969025,
0.011048966087400913,
-0.07067249715328217,
-0.08002249151468277,
0.11856057494878769,
0.06902528554201126,
-0.1711890548467636,
0.19749265909194946,
-0.11000194400548935,
-0.027934154495596886,
0.04736228659749031,
-0.23184843361377716,
-0.0074822562746703625,
0.24927528202533722,
0.1381993293762207,
-0.016726179048419,
0.05371945723891258,
0.05899621918797493,
0.2946510314941406,
-0.11820487678050995,
-0.1477718949317932,
-0.043904416263103485,
-0.0721859484910965,
-0.021199746057391167,
-0.02757882885634899,
-0.08633052557706833,
-0.030028600245714188,
-0.06678874045610428,
0.09711278975009918,
-0.11044219136238098,
0.01452653855085373,
-0.0730321854352951,
-0.12254863977432251,
0.017850618809461594,
0.16624462604522705,
0.07579810172319412,
0.23049454391002655,
-0.008164570666849613,
-0.11738643050193787,
0.06334764510393143,
-0.31366071105003357,
0.12570372223854065,
0.29226985573768616,
-0.03026447631418705,
-0.14403143525123596,
0.15968956053256989,
-0.042374737560749054,
0.22318260371685028,
-0.015300675295293331,
0.06526872515678406,
-0.20720088481903076,
0.021043412387371063,
0.21083854138851166,
-0.09462250024080276,
-0.030506378039717674,
0.11187239736318588,
0.0278653334826231,
-0.14651833474636078,
0.1371920257806778,
0.22785744071006775,
-0.01909690536558628,
0.03725222498178482,
-0.1117309108376503,
-0.0515761636197567,
-0.07209654152393341,
-0.05139564722776413,
0.03197520226240158,
0.032113511115312576,
-0.00009564974607201293,
-0.2500726580619812,
0.29095572233200073,
0.2557373344898224,
0.07433061301708221,
0.1315736621618271,
0.03247962146997452,
-0.0426931157708168,
-0.10245323926210403,
0.12646068632602692,
-0.019150549545884132,
-0.1671859323978424,
-0.07805869728326797,
-0.11614077538251877,
-0.11779217422008514,
-0.15043862164020538,
-0.028628282248973846,
-0.16868939995765686,
-0.059475649148225784,
-0.2220151424407959,
0.04613115265965462,
0.007412375416606665,
0.1465875506401062,
-0.03497818112373352,
-0.1336953341960907,
-0.12241744250059128,
-0.09610889852046967,
-0.016184667125344276,
-0.07283786684274673,
0.24082116782665253,
-0.029533401131629944,
0.027887413278222084,
0.016545521095395088,
-0.013911300338804722,
-0.30643606185913086,
-0.10149001330137253,
0.06622333079576492,
0.07199763506650925,
-0.20621466636657715,
-0.018757982179522514,
-0.19577255845069885,
0.03528013825416565,
-0.02729388140141964,
0.0004389930982142687,
0.03490113094449043,
0.3052210509777069,
0.014711818657815456,
-0.017980201169848442,
-0.12167514115571976,
0.047664251178503036,
0.11643373966217041,
0.023956404998898506,
-0.15107141435146332,
0.2751912772655487,
-0.16828249394893646,
0.16814859211444855,
-0.008647392503917217,
0.3437858521938324,
0.1322665810585022,
0.14195789396762848,
-0.17269884049892426,
0.0299881212413311,
-0.19433589279651642,
0.14509548246860504,
-0.33679714798927307,
-0.04144834727048874,
0.0834631696343422,
0.17487435042858124,
0.03999276086688042,
0.2324288785457611,
0.060831740498542786,
0.06853662431240082,
0.047542277723550797,
0.2552628815174103,
0.015027487650513649,
0.09660780429840088,
-0.030200127512216568,
0.2419356107711792,
0.02408493496477604,
0.11824909597635269,
-0.10492055863142014,
-0.07893800735473633,
0.07323586195707321,
-0.04937467351555824,
-0.12313380092382431,
0.008140737190842628,
-0.045565683394670486,
0.014570008032023907,
0.2204330712556839,
-0.025969281792640686,
-0.05392533168196678,
-0.06718802452087402,
0.029522433876991272,
0.09103737771511078,
0.057383324950933456,
-0.25872817635536194,
0.21412797272205353,
-0.25559940934181213,
0.11188049614429474,
-0.12096085399389267,
0.09011110663414001,
-0.31842413544654846,
0.16514228284358978,
-0.20333145558834076,
-0.021346572786569595,
-0.007349892053753138,
-0.16091284155845642,
-0.03765387088060379,
-0.018773747608065605,
0.11079057306051254,
0.19915279746055603,
0.3177104890346527,
-0.10939399152994156,
0.09071217477321625,
-0.15263903141021729,
0.14060206711292267,
-0.138929545879364,
-0.0022944831289350986,
0.14049957692623138,
0.18835563957691193,
-0.16707412898540497,
-0.19066745042800903,
0.13411907851696014,
0.14034797251224518,
-0.037908341735601425,
0.11194887012243271,
-0.11995243281126022,
-0.152980238199234,
0.05943293869495392,
0.004123128484934568,
-0.036765653640031815,
0.004315967205911875,
0.15616706013679504,
0.024584539234638214,
0.2171645313501358,
-0.0589127279818058,
0.3343711495399475,
-0.035501301288604736,
-0.36512747406959534,
-0.22586029767990112,
0.08945297449827194,
0.18442973494529724,
0.14741963148117065,
0.028291771188378334,
-0.04335837438702583,
0.23381827771663666,
-0.26517388224601746,
0.06399359554052353,
-0.10138393193483353,
0.19186930358409882,
0.058475393801927567,
0.10414129495620728,
0.03987286239862442,
0.5074964165687561,
-0.12142240256071091,
-0.2047598659992218,
-0.2178957611322403,
-0.2045815885066986,
0.08610828220844269,
0.05727289617061615,
0.09914304316043854,
-0.017541220411658287,
-0.21456755697727203,
0.2295835316181183,
-0.1858110874891281,
0.040028877556324005,
-0.06640606373548508,
-0.07646697014570236,
-0.15782643854618073,
0.0029850834980607033,
0.14417880773544312,
-0.011345058679580688,
0.20587167143821716,
-0.10321013629436493,
0.22734153270721436,
-0.1227971687912941,
-0.06461987644433975,
0.08626098930835724,
-0.07224778831005096,
0.01448892243206501,
-0.07855390757322311,
0.03465796262025833,
0.002524395240470767,
-0.018230268731713295,
-0.01425144262611866,
0.08578335493803024,
-0.023773226886987686,
-0.10642675310373306,
-0.014533817768096924,
-0.22396241128444672,
0.06317136436700821,
-0.19380523264408112,
0.028298277407884598,
0.09414764493703842,
-0.10822046548128128,
-0.15481065213680267,
-0.1477372795343399,
-0.07929892838001251,
0.18079784512519836,
-0.01688535325229168,
-0.07678692787885666,
-0.08439037203788757,
0.22480840981006622,
-0.036666885018348694,
-0.0807572528719902,
-0.11153587698936462,
-0.1611015945672989,
0.20113807916641235,
0.2190674990415573,
-0.05199281498789787,
0.09033848345279694,
0.020322440192103386,
0.022480322048068047,
-0.04731201380491257,
-0.1452757716178894,
0.032708264887332916,
0.04990816116333008,
-0.17153865098953247,
0.024172792211174965,
-0.011682887561619282,
-0.009863129816949368,
-0.21006686985492706,
0.183833047747612,
0.15884767472743988,
-0.002568475902080536
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. ;90%)HypoglycemiaElevated 3-OH propionic acid & methylcitric acidHyperglycinemiaElevated propionylcarnitineAnemiaLeukopeniaThrombocytopeniaSee Table 3a (pdf) for a summary of the prevalence of major clinical findings during metabolic crisis in propionic acidemia.Following initial clinical and biochemical stabilization, individuals with neonatal-onset PA may develop a range of symptoms affecting different organ systems. See following and Table 3b (pdf).Late-onset PA. Residual activity of propionyl-CoA carboxylase may delay the onset of symptoms beyond the neonatal period.Individuals with late-onset PA may remain asymptomatic and suffer a metabolic crisis under catabolic stress (e.g., illness, surgery, fasting) or experience a more insidious onset with the development of multiorgan complications as summarized in Table 4. See also Table 3b.Table 4. Features of Late-Onset Propionic AcidemiaView in own windowClinical FeaturesLabora | [
-0.0784054547548294,
0.10888558626174927,
-0.20764124393463135,
-0.23516681790351868,
0.15077613294124603,
0.006120991427451372,
0.043402548879384995,
-0.28803250193595886,
-0.09095373004674911,
-0.16686125099658966,
0.21667517721652985,
0.14520390331745148,
-0.010522706434130669,
0.09555794298648834,
-0.34523046016693115,
0.24157574772834778,
0.07123055309057236,
0.049189116805791855,
-0.12890376150608063,
-0.1736319214105606,
0.029235856607556343,
-0.2164962887763977,
0.02586064115166664,
0.1052837148308754,
0.24383817613124847,
-0.06810779869556427,
0.26563575863838196,
-0.3062760829925537,
0.15167678892612457,
0.017717035487294197,
0.1234675720334053,
0.12260201573371887,
0.10964973270893097,
-0.2865613102912903,
0.05304230377078056,
-0.12089797109365463,
-0.045284464955329895,
-0.14773233234882355,
-0.02776215597987175,
-0.19614823162555695,
0.07433799654245377,
-0.1861429065465927,
0.3252321183681488,
-0.01553567498922348,
0.17549201846122742,
-0.03755927458405495,
-0.041560858488082886,
-0.0732535570859909,
0.015160022303462029,
0.33869585394859314,
0.1734435260295868,
-0.11320555210113525,
-0.3147590458393097,
0.02622239850461483,
0.22135710716247559,
-0.19143512845039368,
-0.11991145461797714,
-0.01714435964822769,
-0.2368151992559433,
0.13936719298362732,
0.1516467034816742,
-0.19314563274383545,
-0.06803401559591293,
-0.24604637920856476,
0.11426760256290436,
-0.05332884564995766,
-0.03602517396211624,
0.0076881228014826775,
0.20695306360721588,
-0.12552469968795776,
0.12526287138462067,
-0.076165109872818,
0.1048644632101059,
0.11018964648246765,
-0.0883256271481514,
0.011607421562075615,
0.0304952971637249,
-0.030530773103237152,
0.04456326365470886,
-0.30416053533554077,
-0.19576288759708405,
0.026502825319767,
0.14710888266563416,
-0.11046554893255234,
-0.17181000113487244,
0.04147333279252052,
0.2429349571466446,
0.06392393261194229,
-0.09733279049396515,
0.14493907988071442,
0.19027820229530334,
0.02012012153863907,
0.08973263949155807,
0.030959447845816612,
0.14062047004699707,
-0.16768895089626312,
0.13103778660297394,
0.007485645357519388,
-0.2448984831571579,
0.05051641911268234,
0.21560576558113098,
-0.002894457196816802,
-0.0807931050658226,
0.08552088588476181,
-0.06015562266111374,
0.23354539275169373,
-0.161432147026062,
-0.02692548744380474,
-0.1277211308479309,
-0.0036525053437799215,
0.11729586124420166,
-0.2002151757478714,
0.13460899889469147,
0.09843858331441879,
-0.5021954774856567,
0.05186501890420914,
-0.14809110760688782,
0.26102539896965027,
-0.011143628507852554,
-0.013553967699408531,
-0.015691502019762993,
0.0769941583275795,
0.11269337683916092,
-0.0641871839761734,
-0.11228823661804199,
0.12250524014234543,
-0.0849032774567604,
-0.0034181619994342327,
0.2240634560585022,
-0.047237709164619446,
0.017008323222398758,
-0.01417777594178915,
-0.0001933130988618359,
-0.06317902356386185,
0.2511613368988037,
-0.06028814613819122,
-0.30263015627861023,
-0.3658778667449951,
-0.14625680446624756,
0.05644439533352852,
0.16812726855278015,
0.23239339888095856,
0.18937794864177704,
0.128578320145607,
0.18897460401058197,
-0.03631839156150818,
0.41432705521583557,
-0.06503096222877502,
0.1622190922498703,
-0.13848371803760529,
-0.011199522763490677,
-0.2848986089229584,
0.046232812106609344,
-0.03853147104382515,
-0.036998994648456573,
0.12957952916622162,
0.037255339324474335,
0.24101851880550385,
-0.1487697809934616,
0.042975183576345444,
-0.035196952521800995,
0.02685505710542202,
0.03197705000638962,
-0.0017058930825442076,
-0.19244708120822906,
0.06715421378612518,
-0.45667004585266113,
-0.034466370940208435,
-0.09602463245391846,
-0.11327080428600311,
-0.05863242596387863,
-0.009896835312247276,
0.023950349539518356,
0.035335201770067215,
0.12892112135887146,
0.034524932503700256,
-0.14490513503551483,
-0.1042429581284523,
0.015074520371854305,
0.19907738268375397,
0.18778851628303528,
0.12378847599029541,
-0.2552482783794403,
-0.002225924516096711,
-0.05918344482779503,
-0.0907483771443367,
0.16433581709861755,
0.25577983260154724,
0.05510144308209419,
0.18700796365737915,
0.19149649143218994,
0.0018257676856592298,
0.08824677020311356,
0.11009286344051361,
0.02648172341287136,
-0.24369913339614868,
0.13748373091220856,
-0.06950866430997849,
-0.12065018713474274,
-0.012892337515950203,
-0.09478569030761719,
-0.04619767144322395,
0.1557314246892929,
-0.10625667870044708,
-0.009844282642006874,
-0.24518387019634247,
0.008862639777362347,
-0.081843800842762,
0.07581249624490738,
0.12125995010137558,
-0.10813447088003159,
0.3009470999240875,
-0.27915385365486145,
-0.035217463970184326,
-0.21521398425102234,
-0.14673955738544464,
0.018246669322252274,
-0.03818821534514427,
-0.009653941728174686,
0.09728650748729706,
-0.07005691528320312,
-0.0047055622562766075,
0.08336654305458069,
-0.2471989095211029,
-0.14994871616363525,
0.010199631564319134,
-0.3530277907848358,
-0.22242750227451324,
0.08571629971265793,
-0.15253064036369324,
-0.1110256239771843,
0.10482645779848099,
-0.018826885148882866,
0.11702639609575272,
-0.02588525041937828,
-0.180750772356987,
-0.2243359386920929,
0.29044637084007263,
-0.17753034830093384,
0.021328458562493324,
-0.3223855197429657,
-0.03842281177639961,
0.07452847063541412,
0.03011145070195198,
0.07944463193416595,
-0.03671176731586456,
0.04925890639424324,
-0.035791993141174316,
0.004102074075490236,
0.139151468873024,
-0.07149812579154968,
0.13782796263694763,
0.04438875988125801,
-0.05947757139801979,
-0.2377544343471527,
-0.15792538225650787,
0.16683430969715118,
0.07466503232717514,
0.10099917650222778,
-0.05699422210454941,
-0.06955485045909882,
0.13250459730625153,
0.0971379429101944,
0.06119458004832268,
0.037945762276649475,
-0.04342801123857498,
-0.14926785230636597,
0.18436801433563232,
0.017137842252850533,
-0.15617211163043976,
-0.03297528252005577,
0.2006356120109558,
0.25352030992507935,
0.007815489545464516,
-0.2108989655971527,
-0.20168659090995789,
0.008180761709809303,
0.13824279606342316,
0.022478226572275162,
0.0698690265417099,
-0.1609618365764618,
0.245589941740036,
-0.14851808547973633,
0.07828502357006073,
0.16200867295265198,
0.021309491246938705,
0.02100922167301178,
0.027655400335788727,
-0.12121545523405075,
0.15111543238162994,
-0.0062482282519340515,
0.1538490206003189,
-0.09207167476415634,
0.04044884815812111,
0.10390093922615051,
0.1314963698387146,
-0.03561757504940033,
0.008522948250174522,
0.06939054280519485,
0.06712120026350021,
0.06348464637994766,
0.18109028041362762,
0.1282491236925125,
-0.06835535913705826,
-0.332585871219635,
-0.06330074369907379,
-0.012662182562053204,
-0.05710742995142937,
0.22187918424606323,
0.22282496094703674,
-0.13219889998435974,
-0.11376893520355225,
-0.2788887023925781,
0.11968470364809036,
-0.18463608622550964,
-0.09392698109149933,
-0.004293912090361118,
0.15000949800014496,
0.13320763409137726,
0.16058073937892914,
-0.0032585691660642624,
0.01431133970618248,
0.012408408336341381,
-0.003869256004691124,
-0.2263583540916443,
-0.05296461656689644,
-0.01790618896484375,
0.12982799112796783,
-0.09847451001405716,
-0.016021251678466797,
0.11340697109699249,
0.09000774472951889,
0.0010863179340958595,
-0.07552877068519592,
0.29398852586746216,
-0.10217782109975815,
0.36438214778900146,
0.02590363472700119,
-0.008129180409014225,
0.06176106259226799,
0.17118459939956665,
-0.44637417793273926,
0.03723745793104172,
-0.23841531574726105,
-0.27447885274887085,
0.05882266163825989,
0.07341289520263672,
0.13777565956115723,
0.052002277225255966,
-0.02840522676706314,
-0.1620662808418274,
-0.047939203679561615,
-0.02618016116321087,
-0.1917143315076828,
0.24174365401268005,
-0.07970552891492844,
-0.018332555890083313,
0.14812412858009338,
0.17188917100429535,
0.05735240504145622,
-0.2746516764163971,
0.1337384581565857,
0.17966516315937042,
-0.127205491065979,
0.11556021124124527,
-0.23760782182216644,
0.0419791005551815,
-0.041502695530653,
0.16563865542411804,
0.04074684903025627,
0.12510482966899872,
0.14580582082271576,
0.11680306494235992,
0.12587280571460724,
-0.1705029010772705,
0.1089850589632988,
-0.03736979141831398,
0.08702965080738068,
-0.3076145350933075,
-0.15002281963825226,
0.18410733342170715,
0.019663451239466667,
0.1856783777475357,
0.12957584857940674,
0.09082973748445511,
0.1321764588356018,
-0.08557957410812378,
0.20357587933540344,
0.2297610342502594,
-0.3951735198497772,
-0.08013349026441574,
0.11401332169771194,
-0.096029132604599,
0.12605081498622894,
0.15598593652248383,
0.1701427549123764,
-0.08499468863010406,
0.09542793035507202,
-0.12329639494419098,
0.12452445179224014,
-0.06981542706489563,
-0.1748705506324768,
0.1644088178873062,
0.11566004902124405,
0.06497611850500107,
0.09742053598165512,
0.0505681149661541,
0.1914253979921341,
-0.06180104613304138,
0.12233620136976242,
-0.05390689894556999,
-0.0543520413339138,
0.10014055669307709,
-0.23615175485610962,
-0.1581794023513794,
-0.0012087931390851736,
-0.07800024002790451,
0.1061435341835022,
0.1418648213148117,
-0.12065854668617249,
-0.01648569107055664,
0.061181679368019104,
0.13945496082305908,
-0.03223257511854172,
-0.10194306820631027,
0.03088180534541607,
0.10388680547475815,
-0.06686656177043915,
0.14006540179252625,
0.20313666760921478,
0.28449347615242004,
-0.044499825686216354,
-0.14013263583183289,
-0.01047693844884634,
0.13455218076705933,
0.0579640232026577,
-0.14056722819805145,
0.20083114504814148,
-0.15247631072998047,
-0.1275957077741623,
0.07802705466747284,
0.05735757574439049,
-0.06532999128103256,
-0.03569493815302849,
-0.24820660054683685,
0.1923408955335617,
0.1974412500858307,
0.14548896253108978,
0.004743450321257114,
0.25447970628738403,
0.040498875081539154,
-0.03939241170883179,
-0.02639039047062397,
-0.0051607610657811165,
0.0844043642282486,
0.1354374885559082,
0.09732446074485779,
-0.09817573428153992,
0.1103719025850296,
0.06164652481675148,
-0.1946619600057602,
0.2370680570602417,
0.18985909223556519,
-0.005861525423824787,
-0.1658853441476822,
0.11193673312664032,
-0.14097250998020172,
0.16404201090335846,
0.03545092046260834,
-0.02705027535557747,
0.0943804532289505,
0.027868373319506645,
-0.130632221698761,
0.12029186636209488,
-0.17713256180286407,
-0.1331338882446289,
0.022597501054406166,
-0.08693946897983551,
-0.0488266684114933,
0.09602775424718857,
0.03350429981946945,
-0.23180760443210602,
0.11309549957513809,
-0.23719583451747894,
-0.0697513222694397,
0.0884731337428093,
-0.1745235025882721,
-0.13727812469005585,
0.3194207549095154,
0.13379329442977905,
-0.01615201123058796,
0.07427293062210083,
0.07841230183839798,
0.3203122615814209,
-0.08750350028276443,
-0.16871346533298492,
-0.003156286897137761,
-0.10873135179281235,
-0.014459901489317417,
0.018124159425497055,
-0.16838790476322174,
-0.14389629662036896,
-0.12770865857601166,
0.16347761452198029,
-0.09659136831760406,
0.12464066594839096,
-0.09880882501602173,
-0.06347829103469849,
0.01587980054318905,
0.25248003005981445,
0.08645804226398468,
0.16881583631038666,
0.014611330814659595,
-0.10553068667650223,
-0.08868929743766785,
-0.22227521240711212,
0.07315374910831451,
0.28774216771125793,
-0.039931196719408035,
-0.2022455334663391,
0.13869349658489227,
-0.061352699995040894,
0.22157026827335358,
0.032993752509355545,
0.08734950423240662,
-0.0037548355758190155,
-0.04388052225112915,
0.230511873960495,
-0.1091524288058281,
-0.08348443359136581,
0.11309482902288437,
-0.08322256058454514,
-0.17291392385959625,
0.061982639133930206,
0.26659920811653137,
0.04769089072942734,
0.0962173119187355,
-0.07320225983858109,
-0.11078929901123047,
-0.07048730552196503,
-0.08400396257638931,
-0.019051751121878624,
-0.015592540614306927,
0.0486326701939106,
-0.30905163288116455,
0.254061222076416,
0.14123426377773285,
0.09391526877880096,
-0.02912801131606102,
0.01310888770967722,
-0.024395929649472237,
-0.06277178972959518,
0.1161828562617302,
0.03708594664931297,
-0.055260058492422104,
-0.10360999405384064,
-0.07876596599817276,
-0.0715816468000412,
-0.21360613405704498,
0.020868860185146332,
-0.1434815376996994,
0.03876642882823944,
-0.2577238380908966,
0.06931722164154053,
0.011776668019592762,
0.15211468935012817,
-0.054225850850343704,
-0.10385730117559433,
-0.11030617356300354,
-0.17159098386764526,
-0.02721298113465309,
-0.012135903351008892,
0.1238606721162796,
-0.1289401650428772,
-0.0906706154346466,
0.06332135945558548,
-0.04587634280323982,
-0.36309224367141724,
-0.04417337104678154,
0.10665988177061081,
0.0796411857008934,
-0.3075069785118103,
0.01818890869617462,
-0.23791912198066711,
-0.08948550373315811,
-0.0709221363067627,
-0.05734197422862053,
0.06153608858585358,
0.34297555685043335,
-0.025976086035370827,
0.01755281537771225,
-0.1488390862941742,
0.08786928653717041,
-0.03508229926228523,
0.06213881075382233,
-0.2615341544151306,
0.15742294490337372,
-0.19521242380142212,
-0.007678464520722628,
0.029166128486394882,
0.2705555260181427,
0.24959209561347961,
0.07929927855730057,
-0.22973830997943878,
-0.053791288286447525,
-0.13045287132263184,
0.12651194632053375,
-0.2611156404018402,
-0.11240676790475845,
-0.02942531742155552,
0.16079655289649963,
0.031063992530107498,
0.0741688460111618,
-0.012810963205993176,
-0.03587878495454788,
-0.053931958973407745,
0.26048406958580017,
-0.09448853880167007,
0.08766651153564453,
-0.10473185777664185,
0.22372153401374817,
-0.003965227864682674,
0.03842635825276375,
-0.09226684272289276,
-0.10999993979930878,
0.12681150436401367,
-0.021914128214120865,
-0.1235080286860466,
0.08202867209911346,
-0.13380791246891022,
0.02599737048149109,
0.23494236171245575,
-0.03856712952256203,
-0.003095173742622137,
-0.14405106008052826,
-0.06043056771159172,
-0.025060730054974556,
0.002514251973479986,
-0.33182522654533386,
0.15751321613788605,
-0.21702712774276733,
0.12741336226463318,
-0.19638977944850922,
0.11428726464509964,
-0.34095391631126404,
0.21978874504566193,
-0.2024611532688141,
-0.13185569643974304,
0.001995994243770838,
-0.174881249666214,
-0.030243203043937683,
0.0002708521205931902,
0.14772596955299377,
0.24048961699008942,
0.32506436109542847,
-0.15881487727165222,
0.1679074615240097,
-0.14914974570274353,
0.21376170217990875,
-0.2685525715351105,
0.014804353006184101,
0.09909743070602417,
0.22268036007881165,
-0.14735782146453857,
-0.18088847398757935,
0.18218755722045898,
0.1361837238073349,
0.031854353845119476,
0.05683988705277443,
-0.29878494143486023,
-0.11147352308034897,
0.006682939827442169,
-0.00850654486566782,
0.13406437635421753,
0.059612564742565155,
0.08931278437376022,
-0.03547023609280586,
0.23703692853450775,
-0.10149803757667542,
0.36328721046447754,
-0.0075228456407785416,
-0.43174564838409424,
-0.2269516885280609,
-0.03554166108369827,
0.22243747115135193,
0.018026795238256454,
-0.06369834393262863,
-0.06567322462797165,
0.21510650217533112,
-0.29420873522758484,
-0.01565987430512905,
-0.12712685763835907,
0.210976704955101,
0.12748855352401733,
0.19379089772701263,
0.04851538687944412,
0.36566123366355896,
-0.15955011546611786,
-0.3938952386379242,
-0.23773783445358276,
-0.13443972170352936,
0.081565260887146,
0.08546283096075058,
0.2514790892601013,
-0.14075611531734467,
-0.22686868906021118,
0.15623222291469574,
-0.27629947662353516,
0.06693681329488754,
-0.09171924740076065,
-0.12450377643108368,
-0.08499771356582642,
0.014711645431816578,
0.13068009912967682,
0.04977109655737877,
0.22066345810890198,
-0.17287807166576385,
0.11743666976690292,
-0.08818715810775757,
-0.16279512643814087,
0.0035549167077988386,
-0.031682416796684265,
-0.03244980797171593,
-0.06963291764259338,
0.0512123629450798,
0.09057049453258514,
0.011508394032716751,
-0.02150009572505951,
0.18367524445056915,
-0.00446065841242671,
-0.13638173043727875,
-0.04558597505092621,
-0.3808470368385315,
0.09590119123458862,
-0.13207530975341797,
0.008339707739651203,
0.027797650545835495,
-0.06531253457069397,
-0.10261454433202744,
-0.22609494626522064,
-0.07891697436571121,
0.10073782503604889,
-0.00413099117577076,
-0.0957043319940567,
-0.04630099609494209,
0.16856923699378967,
0.01065673679113388,
-0.12465669959783554,
-0.1709146648645401,
-0.2180580049753189,
0.1679961234331131,
0.10464929044246674,
-0.07422365993261337,
0.08948391675949097,
0.0449257455766201,
-0.018849752843379974,
-0.03800106793642044,
-0.18359827995300293,
0.09650123864412308,
0.03112727403640747,
-0.2210770845413208,
0.02515343576669693,
0.07117220014333725,
0.055578168481588364,
-0.17152871191501617,
0.2340725213289261,
0.14679348468780518,
0.2138058841228485
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. .Late-onset PA. Residual activity of propionyl-CoA carboxylase may delay the onset of symptoms beyond the neonatal period.Individuals with late-onset PA may remain asymptomatic and suffer a metabolic crisis under catabolic stress (e.g., illness, surgery, fasting) or experience a more insidious onset with the development of multiorgan complications as summarized in Table 4. See also Table 3b.Table 4. Features of Late-Onset Propionic AcidemiaView in own windowClinical FeaturesLaboratory FindingsEncephalopathy, coma, and/or seizures precipitated by catabolic stressors (e.g., intercurrent illness, surgery)Vomiting, protein intolerance, failure to thrive, hypotonia, developmental regression, movement disordersIsolated cardiomyopathy 1
± metabolic acidosis or hyperammonemiaElevated 3-OH propionic acid & methylcitric acidHyperglycinemiaMRI abnormalities including basal ganglia lesions 2
1. Lee et al 2. Broomfield et | [
-0.11796113103628159,
0.06934612989425659,
-0.18983396887779236,
-0.15084950625896454,
0.13690243661403656,
-0.0808081403374672,
-0.04633226990699768,
-0.23506349325180054,
-0.03788948431611061,
-0.19162432849407196,
0.18524590134620667,
0.02649129554629326,
0.0019231887999922037,
0.04301309585571289,
-0.34668827056884766,
0.18438991904258728,
0.01882394216954708,
-0.05085090547800064,
-0.17913192510604858,
-0.18180148303508759,
0.05479167029261589,
-0.1641700714826584,
0.0633588507771492,
0.1261747181415558,
0.3284384310245514,
-0.06796936690807343,
0.20248359441757202,
-0.2646258771419525,
0.17940546572208405,
0.06630473583936691,
0.014596368186175823,
0.16269168257713318,
0.13415350019931793,
-0.33516013622283936,
0.0010513282613828778,
-0.20711104571819305,
-0.10191977024078369,
-0.17205233871936798,
-0.007795774377882481,
-0.30901455879211426,
0.04963662102818489,
-0.11716929078102112,
0.3045806288719177,
-0.013360096141695976,
0.14675608277320862,
-0.00034044982749037445,
0.00794992782175541,
-0.08802680671215057,
-0.12367425858974457,
0.2961278259754181,
0.09966380894184113,
-0.13947074115276337,
-0.2640397548675537,
0.10999283939599991,
0.25289610028266907,
-0.2512226998806,
-0.1571052521467209,
0.009749880991876125,
-0.17538310587406158,
0.1501588672399521,
0.18335551023483276,
-0.16400398313999176,
-0.17064118385314941,
-0.27404412627220154,
0.1075863242149353,
-0.061489734798669815,
-0.12686969339847565,
0.03565949201583862,
0.22662019729614258,
-0.0980839654803276,
0.12692008912563324,
-0.10847335308790207,
0.017875347286462784,
0.11151959002017975,
-0.13000904023647308,
-0.04556271433830261,
0.11528128385543823,
0.0008541547576896846,
-0.09146612137556076,
-0.2750537693500519,
-0.2548787295818329,
-0.03728215768933296,
0.08948183059692383,
-0.21862132847309113,
-0.18559420108795166,
0.07746618241071701,
0.14376048743724823,
0.13115012645721436,
-0.037626344710588455,
0.1447935253381729,
0.21436357498168945,
0.11376563459634781,
0.014803806319832802,
0.05613458529114723,
0.1256849318742752,
-0.07170578092336655,
0.16406045854091644,
0.030759597197175026,
-0.21320649981498718,
0.0689462199807167,
0.22443599998950958,
0.04125729948282242,
0.018893707543611526,
0.015317652374505997,
-0.037642575800418854,
0.21142588555812836,
-0.16662795841693878,
-0.004698507022112608,
-0.05905735120177269,
-0.024215472862124443,
0.03881307318806648,
-0.17781300842761993,
0.23937225341796875,
0.12033940106630325,
-0.48901230096817017,
0.034417398273944855,
-0.11698845028877258,
0.2311217486858368,
-0.021167777478694916,
0.0654374361038208,
-0.05653074383735657,
0.05608299374580383,
0.13193289935588837,
0.049881741404533386,
-0.0646013393998146,
0.11692854762077332,
0.0459880530834198,
0.05335775762796402,
0.2134658396244049,
-0.018702520057559013,
0.03958103805780411,
-0.08336523175239563,
0.06921348720788956,
-0.11500855535268784,
0.1588330864906311,
-0.10061927139759064,
-0.3620729446411133,
-0.35515108704566956,
-0.05024136230349541,
0.07904976606369019,
0.2000764161348343,
0.3016009032726288,
0.17106257379055023,
0.13723285496234894,
0.24138310551643372,
0.021779431030154228,
0.3746204078197479,
-0.030546987429261208,
0.18271397054195404,
-0.043580494821071625,
-0.11744872480630875,
-0.25402140617370605,
0.1585610955953598,
0.06656862050294876,
0.05141577869653702,
0.1295313686132431,
0.025351176038384438,
0.24764317274093628,
-0.11923602223396301,
0.004941040184348822,
-0.13062052428722382,
-0.016739515587687492,
-0.025848068296909332,
0.09905937314033508,
-0.1770457923412323,
0.14918577671051025,
-0.5237963199615479,
-0.18009717762470245,
0.02446051687002182,
-0.09992052614688873,
-0.03393476828932762,
-0.06861153990030289,
-0.12465950101613998,
0.13594745099544525,
0.012751244939863682,
-0.101493239402771,
-0.10538998991250992,
-0.09488552808761597,
-0.0303835216909647,
0.21833881735801697,
0.19959717988967896,
0.07933876663446426,
-0.2789360284805298,
0.05051805451512337,
-0.07093381881713867,
-0.0476466603577137,
0.1369755119085312,
0.2094428837299347,
-0.03926766291260719,
0.08953335136175156,
0.2048463672399521,
-0.0075700124725699425,
0.025671958923339844,
0.07950583100318909,
-0.06246687099337578,
-0.20822255313396454,
0.15719223022460938,
-0.07933647185564041,
-0.05437881126999855,
0.043386973440647125,
-0.19294971227645874,
-0.07852727174758911,
0.2458452433347702,
0.04453595355153084,
-0.05475448817014694,
-0.12680207192897797,
-0.05517718195915222,
-0.08926861733198166,
0.06170494109392166,
0.18129947781562805,
-0.10831370949745178,
0.29136234521865845,
-0.25097009539604187,
-0.1105048730969429,
-0.20314915478229523,
-0.06055545434355736,
-0.00471224170178175,
0.02887258119881153,
-0.05783702805638313,
0.13448254764080048,
0.006669249851256609,
-0.06559514254331589,
0.04795955866575241,
-0.165746808052063,
-0.08219753205776215,
-0.05602531507611275,
-0.35419127345085144,
-0.31905844807624817,
0.12677937746047974,
-0.14574271440505981,
-0.15259963274002075,
0.10696682333946228,
0.014546440914273262,
0.1616174280643463,
0.033283088356256485,
-0.1445029079914093,
-0.22695454955101013,
0.2839653789997101,
-0.2289426177740097,
-0.0014036839129403234,
-0.41688066720962524,
-0.14674945175647736,
-0.06045040488243103,
-0.07352504134178162,
0.087004154920578,
-0.017314476892352104,
0.03461197763681412,
0.0631004124879837,
-0.09213768690824509,
0.11581413447856903,
-0.05334401875734329,
0.11790978908538818,
0.024516982957720757,
-0.02359856478869915,
-0.3002021610736847,
-0.1807917207479477,
0.1622515320777893,
0.06636117398738861,
0.11016368120908737,
-0.14307217299938202,
-0.1280934065580368,
0.19785001873970032,
0.0002580215805210173,
0.07032456994056702,
0.15154984593391418,
-0.026349009945988655,
-0.09917047619819641,
0.2436593621969223,
-0.01987989991903305,
-0.17682991921901703,
-0.08464343100786209,
0.200203076004982,
0.22694653272628784,
-0.05599610134959221,
-0.2582114636898041,
-0.20472636818885803,
0.039320606738328934,
0.19458992779254913,
0.05153493955731392,
-0.038496751338243484,
-0.1300768107175827,
0.2814088463783264,
-0.012938394211232662,
0.014129470102488995,
0.21058721840381622,
0.06983941793441772,
-0.001099263783544302,
-0.017021603882312775,
-0.12207939475774765,
0.20069213211536407,
-0.028537418693304062,
0.10993063449859619,
-0.15941715240478516,
-0.047874849289655685,
0.09737446904182434,
0.06578247249126434,
0.04539276659488678,
-0.010955441743135452,
0.07252173870801926,
0.11599349230527878,
-0.015203770250082016,
0.11103320866823196,
0.23311087489128113,
-0.02303779125213623,
-0.31095731258392334,
0.015425167046487331,
-0.0006481542368419468,
-0.08439496159553528,
0.1962529867887497,
0.24814069271087646,
-0.07479817420244217,
-0.09948347508907318,
-0.1788097470998764,
0.03671463578939438,
-0.26172277331352234,
-0.001863872166723013,
0.012164129875600338,
0.1046537458896637,
0.1763819456100464,
0.17280468344688416,
-0.08355176448822021,
0.04757906123995781,
0.031105399131774902,
0.07633744180202484,
-0.13820913434028625,
-0.13936841487884521,
-0.12486341595649719,
0.08443339169025421,
-0.12878291308879852,
0.0399613194167614,
0.019299224019050598,
0.15863458812236786,
0.015492713078856468,
-0.10183599591255188,
0.22984953224658966,
-0.14711065590381622,
0.323208212852478,
0.08786782622337341,
-0.027347123250365257,
0.07735851407051086,
0.13666611909866333,
-0.3591326177120209,
-0.045814305543899536,
-0.341222882270813,
-0.20480969548225403,
0.11793001741170883,
0.013158651068806648,
0.15437880158424377,
0.03315320238471031,
-0.014579801820218563,
-0.15852481126785278,
0.10185620933771133,
-0.009244933724403381,
-0.1725963056087494,
0.1904916614294052,
-0.10939386487007141,
-0.154113307595253,
0.12132791429758072,
0.16704492270946503,
0.13698022067546844,
-0.27886128425598145,
0.08028312027454376,
0.19547788798809052,
-0.12319330871105194,
0.10105541348457336,
-0.28916192054748535,
0.07138274610042572,
-0.06351014971733093,
0.2684069573879242,
0.002966888016089797,
0.08644985407590866,
0.05589844286441803,
0.10489928722381592,
0.0737747922539711,
-0.16407117247581482,
0.14710666239261627,
-0.044115521013736725,
-0.019629215821623802,
-0.29683440923690796,
-0.06543845683336258,
0.25543802976608276,
-0.010632743127644062,
0.2263411432504654,
0.04535426199436188,
0.06849338114261627,
0.07649186253547668,
-0.11279036104679108,
0.2541358172893524,
0.29727017879486084,
-0.4368097484111786,
-0.05160844326019287,
0.1111740916967392,
-0.10905032604932785,
0.09226330369710922,
0.14133891463279724,
0.18549232184886932,
0.01672925241291523,
0.1193571537733078,
-0.13841977715492249,
0.02577023208141327,
-0.08864369988441467,
-0.09167071431875229,
0.1568215936422348,
-0.015048950910568237,
0.007229930721223354,
0.12299199402332306,
0.15777766704559326,
0.1966765969991684,
-0.05791453272104263,
0.07405619323253632,
-0.013501838780939579,
-0.19790396094322205,
0.003322660457342863,
-0.18222233653068542,
-0.10584627836942673,
-0.03756287321448326,
0.057130154222249985,
0.15663868188858032,
0.22021156549453735,
-0.14481113851070404,
-0.06868666410446167,
0.05957959592342377,
0.18598775565624237,
-0.006724715232849121,
-0.010747802443802357,
0.05915764346718788,
0.051193952560424805,
-0.050032228231430054,
0.17543776333332062,
0.23886296153068542,
0.3452649712562561,
-0.03250323235988617,
-0.07325239479541779,
-0.027039876207709312,
0.19778688251972198,
0.0807705670595169,
-0.22384797036647797,
0.14556705951690674,
-0.12595105171203613,
-0.12139733135700226,
0.09033636748790741,
0.021688394248485565,
-0.02397635020315647,
-0.15582768619060516,
-0.20671090483665466,
0.22707267105579376,
0.219638392329216,
0.16169703006744385,
0.01678641326725483,
0.2976483106613159,
0.08286513388156891,
0.026541486382484436,
0.01304129883646965,
0.04315667971968651,
0.16127537190914154,
0.10416558384895325,
0.07629074156284332,
-0.019543156027793884,
0.10901591181755066,
0.04742082208395004,
-0.15446878969669342,
0.18844085931777954,
0.2768646776676178,
0.000055051477829692885,
-0.20955392718315125,
0.18548546731472015,
-0.14480005204677582,
0.18119628727436066,
-0.01829562708735466,
-0.030928485095500946,
0.016483381390571594,
0.05469396710395813,
-0.14441537857055664,
0.16306374967098236,
-0.20159609615802765,
-0.20737753808498383,
-0.07365458458662033,
-0.03510294482111931,
0.02198249101638794,
-0.030004773288965225,
-0.030809052288532257,
-0.09611357748508453,
0.05357203632593155,
-0.11354447901248932,
-0.10016459226608276,
0.08988196402788162,
-0.15887007117271423,
0.002282876754179597,
0.3517795205116272,
0.1277337521314621,
-0.012608988210558891,
0.15343816578388214,
-0.025801653042435646,
0.38774803280830383,
-0.1559450477361679,
-0.18767066299915314,
0.034653447568416595,
-0.088773213326931,
-0.03792388737201691,
-0.05021142214536667,
-0.13395985960960388,
-0.16148753464221954,
-0.06535955518484116,
0.09641318023204803,
-0.0740668997168541,
0.04218734800815582,
-0.08039383590221405,
-0.13417556881904602,
-0.07660933583974838,
0.17712661623954773,
0.07328017801046371,
0.20425035059452057,
-0.04842965677380562,
-0.1488630771636963,
0.03918689861893654,
-0.20391671359539032,
0.12457796186208725,
0.3452874422073364,
-0.047636792063713074,
-0.20230941474437714,
0.0836334377527237,
-0.06490521132946014,
0.1516006588935852,
0.07124771922826767,
0.10300107300281525,
-0.059145908802747726,
0.08322202414274216,
0.11099403351545334,
-0.06643349677324295,
-0.10758820176124573,
0.07166067510843277,
-0.09626439958810806,
-0.2966291904449463,
-0.057048872113227844,
0.24268792569637299,
0.029942205175757408,
0.1330161988735199,
-0.08226525783538818,
-0.08085951209068298,
-0.1399322748184204,
-0.1152963861823082,
-0.023229019716382027,
-0.004233567509800196,
0.04408106207847595,
-0.19941933453083038,
0.22337807714939117,
0.1972751021385193,
0.11181243509054184,
-0.013322163373231888,
-0.005504000000655651,
-0.05524563789367676,
-0.14353279769420624,
0.04613450542092323,
0.06298389285802841,
-0.012898611836135387,
-0.08304085582494736,
-0.1894165426492691,
-0.12160991877317429,
-0.3235943615436554,
0.07027018815279007,
-0.12336365133523941,
-0.07987835258245468,
-0.25285980105400085,
0.08329124748706818,
-0.029371842741966248,
0.12015611678361893,
-0.04047425091266632,
-0.05475696176290512,
-0.02769686095416546,
-0.1540394425392151,
0.013348396867513657,
-0.04070960730314255,
0.06915504485368729,
-0.0694207102060318,
-0.09808146208524704,
0.14640220999717712,
-0.05396672338247299,
-0.33484557271003723,
-0.11211103945970535,
0.09746058285236359,
0.002370222005993128,
-0.3724745213985443,
0.045266665518283844,
-0.358275443315506,
0.046830691397190094,
-0.11245115101337433,
0.049602754414081573,
-0.03891344368457794,
0.421710729598999,
-0.05473744496703148,
0.017510490491986275,
-0.10824663192033768,
0.08932720869779587,
0.022443167865276337,
0.11704912781715393,
-0.23653139173984528,
0.10456649959087372,
-0.2304694503545761,
0.05627107247710228,
0.009881606325507164,
0.3141017556190491,
0.17438159883022308,
-0.0477992445230484,
-0.2772994041442871,
-0.15210983157157898,
-0.14904259145259857,
0.04919243976473808,
-0.2821214199066162,
-0.11566215753555298,
0.06678851693868637,
0.25527358055114746,
0.1300598680973053,
0.12536539137363434,
-0.07525752484798431,
0.030018985271453857,
-0.025876350700855255,
0.17411750555038452,
-0.022785037755966187,
0.11412937939167023,
-0.08198989927768707,
0.15963305532932281,
-0.1119084507226944,
0.12717656791210175,
-0.04255971312522888,
-0.21284610033035278,
0.05349016934633255,
-0.06327519565820694,
-0.08115245401859283,
-0.019992738962173462,
-0.10612025856971741,
-0.05356465280056,
0.25729241967201233,
0.036627188324928284,
-0.03588731586933136,
-0.1682170033454895,
-0.05570440739393234,
0.10287763923406601,
0.12786737084388733,
-0.2413187026977539,
0.2845190465450287,
-0.17037411034107208,
0.06363661587238312,
-0.20268259942531586,
0.027992963790893555,
-0.2788469195365906,
0.10414457321166992,
-0.2765845060348511,
-0.17830340564250946,
-0.057225022464990616,
-0.1791103333234787,
0.050387170165777206,
-0.05859857052564621,
0.09859727323055267,
0.12717658281326294,
0.2804926037788391,
-0.22137479484081268,
0.08362012356519699,
-0.03936002030968666,
0.19662223756313324,
-0.2164047360420227,
0.06092485412955284,
0.1591784805059433,
0.14721332490444183,
-0.11132640391588211,
-0.21322624385356903,
0.22295784950256348,
0.09451612085103989,
0.042241960763931274,
0.12033356726169586,
-0.2801532745361328,
-0.19062598049640656,
-0.057649966329336166,
0.038988783955574036,
0.17989160120487213,
0.03445548564195633,
0.027016663923859596,
-0.018160821869969368,
0.16172869503498077,
-0.05418087914586067,
0.404722660779953,
0.07620243728160858,
-0.42860284447669983,
-0.2058962732553482,
-0.016644949093461037,
0.31354668736457825,
0.11533733457326889,
-0.012486575171351433,
-0.08918681740760803,
0.2848218083381653,
-0.2793820798397064,
0.021424856036901474,
-0.1041504368185997,
0.16858649253845215,
0.044644370675086975,
0.11720331758260727,
0.03495531156659126,
0.3848714232444763,
-0.18929025530815125,
-0.40106549859046936,
-0.2381606549024582,
-0.18113356828689575,
0.0826810970902443,
0.16396036744117737,
0.20284271240234375,
-0.08423256129026413,
-0.31436213850975037,
0.2054550051689148,
-0.2322266697883606,
0.08095142990350723,
-0.16759265959262848,
-0.15220971405506134,
-0.08687180280685425,
0.05277713015675545,
0.22874946892261505,
0.014396284706890583,
0.12646332383155823,
-0.06440480053424835,
0.10721884667873383,
-0.13311606645584106,
-0.22535286843776703,
0.0515839159488678,
-0.08776099979877472,
-0.053959812968969345,
0.024899013340473175,
-0.06745003163814545,
0.03165203705430031,
-0.005890423431992531,
-0.033178169280290604,
0.06919097900390625,
-0.023034607991576195,
-0.20101381838321686,
-0.03178156167268753,
-0.3994045555591583,
0.11086934059858322,
-0.11916358768939972,
-0.007398327346891165,
-0.01570611074566841,
-0.09800808876752853,
-0.06043989956378937,
-0.19964314997196198,
-0.131422221660614,
0.07325559854507446,
0.21335606276988983,
-0.0011559352278709412,
-0.05863432213664055,
0.07665415853261948,
-0.06914579123258591,
-0.04854395613074303,
-0.14435338973999023,
-0.18510669469833374,
0.07877559214830399,
0.14423814415931702,
0.021254559978842735,
0.12324371933937073,
0.0029448377899825573,
0.08106300979852676,
-0.0698961541056633,
-0.18685024976730347,
0.02618693932890892,
0.00020769379625562578,
-0.2236981987953186,
0.03530294820666313,
0.07199031859636307,
0.17323046922683716,
-0.11728868633508682,
0.1987471580505371,
0.17582951486110687,
0.24196937680244446
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. windowClinical FeaturesLaboratory FindingsEncephalopathy, coma, and/or seizures precipitated by catabolic stressors (e.g., intercurrent illness, surgery)Vomiting, protein intolerance, failure to thrive, hypotonia, developmental regression, movement disordersIsolated cardiomyopathy 1
± metabolic acidosis or hyperammonemiaElevated 3-OH propionic acid & methylcitric acidHyperglycinemiaMRI abnormalities including basal ganglia lesions 2
1. Lee et al 2. Broomfield et al Metabolic decompensations. Children with PA can develop episodic metabolic decompensations, especially in the first years of life. Acidosis, hyperammonemia, pancreatitis, metabolic stroke, cardiomyopathy, bone marrow suppression, seizures, and encephalopathy can accompany acutely deranged metabolism. These episodes can be life-threatening and are often precipitated by illnesses, infections, surgery, or any stress augmenting catabolism. Infectious complications (e.g., sepsis or bacterial meningitis) often accompany metabolic crises and | [
-0.09097524732351303,
-0.010672276839613914,
-0.1423981487751007,
-0.15392740070819855,
0.03054482489824295,
-0.07896509021520615,
-0.012022114358842373,
-0.21088790893554688,
-0.05404596030712128,
-0.18090921640396118,
0.1603502631187439,
-0.06613900512456894,
0.016212372109293938,
-0.00824679434299469,
-0.24639268219470978,
0.13095282018184662,
0.03599921613931656,
-0.07529392093420029,
-0.10473129153251648,
-0.08841410279273987,
-0.07939108461141586,
-0.2096279263496399,
-0.08126474171876907,
0.1818961352109909,
0.37655073404312134,
-0.19029510021209717,
0.1819661557674408,
-0.32924044132232666,
0.13176780939102173,
0.00045083416625857353,
-0.01916293427348137,
0.050428807735443115,
0.17430774867534637,
-0.2646736204624176,
-0.08126068860292435,
-0.21149282157421112,
-0.07389354705810547,
-0.23561273515224457,
-0.02857218123972416,
-0.24275241792201996,
0.11227458715438843,
-0.1515408307313919,
0.26232874393463135,
0.05167686566710472,
0.18400344252586365,
-0.04771580547094345,
-0.008147630840539932,
-0.08423704653978348,
-0.07091767340898514,
0.2936570644378662,
0.09498540312051773,
-0.10754209756851196,
-0.32433104515075684,
0.03962526470422745,
0.15032532811164856,
-0.251181036233902,
-0.13014185428619385,
-0.0696122944355011,
-0.0773884505033493,
0.148823544383049,
0.037108901888132095,
-0.24185168743133545,
-0.25192078948020935,
-0.34770074486732483,
0.16017882525920868,
-0.033700305968523026,
-0.11839032173156738,
0.1333315521478653,
0.17452006042003632,
-0.14518973231315613,
0.21297729015350342,
-0.0552637092769146,
-0.12362980097532272,
0.17004331946372986,
0.03278607130050659,
-0.01367256511002779,
0.15386801958084106,
0.02606547251343727,
-0.0938236191868782,
-0.277767151594162,
-0.26501160860061646,
-0.05263904109597206,
0.026275407522916794,
-0.19474659860134125,
-0.1330723613500595,
0.10066895186901093,
0.13578175008296967,
0.035403285175561905,
-0.05472330376505852,
0.21318310499191284,
0.09288118034601212,
0.05686385557055473,
-0.14984095096588135,
0.12411337345838547,
0.09211573749780655,
-0.06414680927991867,
0.0721043050289154,
0.08837466686964035,
-0.24556772410869598,
0.179097518324852,
0.09626903384923935,
0.05072789639234543,
-0.12512750923633575,
0.007418161258101463,
-0.008246210403740406,
0.15600495040416718,
-0.09947199374437332,
-0.035486333072185516,
-0.03809526562690735,
0.03318100795149803,
0.0954936221241951,
-0.22425763309001923,
0.23140107095241547,
0.15191377699375153,
-0.583257257938385,
-0.030270591378211975,
-0.1795227825641632,
0.2329510748386383,
0.0522756464779377,
-0.0943254828453064,
0.009614743292331696,
0.20956623554229736,
0.03326227888464928,
0.11578090488910675,
0.01241457462310791,
-0.0163247212767601,
0.04919206351041794,
-0.012264742515981197,
0.1371481716632843,
-0.05977087840437889,
0.185700461268425,
-0.0028299097903072834,
0.02952028438448906,
-0.25377127528190613,
0.19952000677585602,
-0.10755416750907898,
-0.2544414699077606,
-0.34030550718307495,
0.022561388090252876,
0.0695064514875412,
0.23892618715763092,
0.25434762239456177,
0.14398616552352905,
0.18138329684734344,
0.11537591367959976,
0.10554316639900208,
0.2936222553253174,
-0.0581417940557003,
0.09379362314939499,
0.021473843604326248,
-0.15885134041309357,
-0.25061288475990295,
0.14120106399059296,
-0.12012746930122375,
-0.09206975996494293,
0.11380994319915771,
0.02715882658958435,
0.25368067622184753,
-0.15241532027721405,
0.053585123270750046,
-0.13693635165691376,
0.007453005760908127,
-0.007754520047456026,
0.06936218589544296,
-0.2582123875617981,
0.10512356460094452,
-0.35259926319122314,
-0.007647988386452198,
-0.05964670702815056,
-0.0711476132273674,
-0.0301782488822937,
-0.061083462089300156,
0.032316602766513824,
0.0944976657629013,
0.00008472475747112185,
-0.11316456645727158,
-0.16497839987277985,
-0.06049278751015663,
-0.0661739781498909,
0.24323564767837524,
0.17107079923152924,
0.02430838719010353,
-0.40744704008102417,
0.03203071281313896,
-0.06351382285356522,
-0.06995799392461777,
0.14022181928157806,
0.1428258866071701,
0.02277655154466629,
0.20683729648590088,
0.13203057646751404,
0.014097023755311966,
0.12393181025981903,
0.027709949761629105,
-0.014197221957147121,
-0.1653379648923874,
0.09512945264577866,
-0.05457623302936554,
-0.08330391347408295,
-0.03533245623111725,
-0.2177540361881256,
-0.09833100438117981,
0.12878680229187012,
-0.03878867253661156,
-0.12269233912229538,
-0.04275055602192879,
0.13627035915851593,
0.005190037656575441,
0.11221057921648026,
0.06261694431304932,
-0.21219025552272797,
0.19022952020168304,
-0.2903919816017151,
-0.07606083899736404,
-0.2670375406742096,
0.00743795745074749,
-0.12597911059856415,
0.013839016668498516,
-0.07981131225824356,
-0.01047813892364502,
-0.032836247235536575,
-0.17177990078926086,
0.11574573069810867,
-0.10961367934942245,
-0.12665465474128723,
-0.1203465536236763,
-0.30598148703575134,
-0.1917700320482254,
0.15757325291633606,
-0.1853187531232834,
-0.14323681592941284,
0.14044968783855438,
-0.013924704864621162,
0.21589607000350952,
-0.11450017243623734,
-0.1660350114107132,
-0.17408360540866852,
0.2741343677043915,
-0.26474496722221375,
-0.04180404916405678,
-0.4679707884788513,
-0.013374804519116879,
0.09081654250621796,
-0.05990274250507355,
0.029693730175495148,
0.05515223741531372,
-0.037700194865465164,
0.10988523066043854,
-0.010059853084385395,
0.09038017690181732,
-0.02455856092274189,
0.1389554888010025,
0.056052688509225845,
0.024802636355161667,
-0.37887072563171387,
-0.2082805186510086,
0.10078396648168564,
0.019092600792646408,
0.08173918724060059,
-0.06910381466150284,
-0.19067223370075226,
0.10784613341093063,
-0.007142120972275734,
0.09744660556316376,
0.10067062079906464,
-0.053047653287649155,
-0.07915565371513367,
0.19058741629123688,
-0.06051226705312729,
-0.16627877950668335,
-0.08106809109449387,
0.2643890082836151,
0.10834688693284988,
0.09087161719799042,
-0.3529897928237915,
-0.08213380724191666,
0.12419889867305756,
0.11406049132347107,
0.041914645582437515,
-0.02329704910516739,
-0.13689565658569336,
0.27542728185653687,
0.09302814304828644,
0.01464157085865736,
0.21445421874523163,
0.09889619052410126,
-0.028991609811782837,
-0.001343686948530376,
-0.03312746062874794,
0.1429549753665924,
0.0015835791127756238,
0.13964451849460602,
-0.030126549303531647,
0.06348174810409546,
0.11315560340881348,
0.07956025004386902,
-0.03226645663380623,
0.012983037158846855,
-0.038845229893922806,
0.1314694732427597,
-0.1382882297039032,
0.18597382307052612,
0.14272935688495636,
0.02589895948767662,
-0.282814085483551,
0.059301529079675674,
-0.00573109881952405,
-0.09543407708406448,
0.1542540043592453,
0.3078225255012512,
-0.10011616349220276,
-0.21230857074260712,
-0.15595024824142456,
-0.024899223819375038,
-0.19023598730564117,
0.08771342784166336,
-0.013897952623665333,
0.2124132215976715,
0.1709883064031601,
0.18180863559246063,
-0.08055390417575836,
0.054178591817617416,
0.17066708207130432,
0.09665501862764359,
-0.1616867333650589,
-0.11435779929161072,
-0.03094884566962719,
0.09541899710893631,
0.018851930275559425,
0.06985409557819366,
0.0851864367723465,
0.13865336775779724,
0.07884395867586136,
-0.11528025567531586,
0.23639798164367676,
-0.2235882580280304,
0.3258797824382782,
-0.0003620921925175935,
-0.03033258579671383,
0.11417718231678009,
0.17917820811271667,
-0.48383140563964844,
-0.02583876997232437,
-0.2937683165073395,
-0.18257850408554077,
0.18417038023471832,
-0.042241763323545456,
0.16270996630191803,
0.07439560443162918,
0.05387032404541969,
-0.1410011649131775,
0.0827774927020073,
-0.047688934952020645,
-0.21820619702339172,
0.2341509461402893,
-0.10204550623893738,
-0.2728482484817505,
0.14050167798995972,
0.09563475102186203,
0.24872654676437378,
-0.3122986853122711,
0.06359800696372986,
0.06972305476665497,
-0.2651335895061493,
0.0712309256196022,
-0.25010380148887634,
-0.033557672053575516,
-0.05953525751829147,
0.15357403457164764,
-0.08406974375247955,
-0.005448095966130495,
0.12123318761587143,
0.13873758912086487,
0.05506215617060661,
-0.15975326299667358,
0.09185820817947388,
-0.048163432627916336,
-0.0704292505979538,
-0.42691877484321594,
-0.12980493903160095,
0.18434251844882965,
0.011599021963775158,
0.15087240934371948,
-0.06418648362159729,
0.01936054788529873,
0.020773500204086304,
-0.11757483333349228,
0.24010680615901947,
0.29689836502075195,
-0.43344762921333313,
0.05072982609272003,
0.168915256857872,
-0.05929090827703476,
0.14477068185806274,
0.1039421483874321,
0.12898147106170654,
0.09066031873226166,
0.13120894134044647,
-0.14798136055469513,
0.0419120192527771,
0.035232771188020706,
0.06655475497245789,
0.2892959713935852,
0.1342260092496872,
0.0997801125049591,
0.11430127173662186,
0.0556727834045887,
0.08392693847417831,
-0.1699451059103012,
0.15395237505435944,
-0.04281510412693024,
-0.1394462287425995,
-0.06676682084798813,
-0.2382894605398178,
-0.09780457615852356,
-0.011366523802280426,
-0.0199320949614048,
0.14135964214801788,
0.17978453636169434,
-0.00770609499886632,
-0.0665234699845314,
0.06500353664159775,
0.0180311668664217,
-0.0268586203455925,
-0.23157787322998047,
0.14783014357089996,
0.10016017407178879,
-0.06387263536453247,
0.09845297783613205,
0.21094653010368347,
0.19244959950447083,
0.02966102957725525,
-0.027650712057948112,
0.02193107083439827,
0.1491292119026184,
0.16608573496341705,
-0.2149190753698349,
0.10758727043867111,
-0.1566699743270874,
-0.1298437863588333,
0.1641951948404312,
0.001750017050653696,
0.06527233123779297,
-0.005884988233447075,
-0.11930521577596664,
0.17244946956634521,
0.17845767736434937,
0.15822547674179077,
0.012086362577974796,
0.26657307147979736,
0.1044316217303276,
-0.038119666278362274,
-0.00016067844990175217,
0.07630034536123276,
0.1817215085029602,
0.06684978306293488,
0.0840875655412674,
-0.10017502307891846,
0.12465447932481766,
-0.07524783909320831,
-0.23949165642261505,
0.08257666975259781,
0.25576362013816833,
-0.1263016313314438,
-0.23612618446350098,
0.11372142285108566,
-0.2536925673484802,
0.093351349234581,
-0.0020629719365388155,
0.12016398459672928,
0.10633625835180283,
0.12093638628721237,
-0.07125640660524368,
0.18001767992973328,
-0.1468837559223175,
-0.1083897054195404,
-0.004040129948407412,
-0.04981441795825958,
-0.09102440625429153,
0.07958941161632538,
-0.02389281615614891,
-0.12082880735397339,
0.12150063365697861,
-0.12385198473930359,
-0.1396894007921219,
0.0845332145690918,
-0.2116919308900833,
0.22117264568805695,
0.2896096408367157,
0.09557810425758362,
0.023124506697058678,
0.06871363520622253,
-0.07069441676139832,
0.480099618434906,
-0.06984662264585495,
-0.13832533359527588,
-0.03590495139360428,
-0.2124369740486145,
0.068271204829216,
0.042022138833999634,
-0.12884481251239777,
-0.07010789960622787,
-0.14978501200675964,
0.041839390993118286,
-0.05444822832942009,
0.00008936863741837442,
0.038438890129327774,
-0.16063885390758514,
-0.15317732095718384,
0.21479643881320953,
0.08385205268859863,
0.11555247753858566,
-0.048213228583335876,
-0.09592852741479874,
0.14792683720588684,
-0.19617486000061035,
0.17904537916183472,
0.2908477783203125,
0.051918875426054,
-0.20080572366714478,
0.1346755176782608,
0.07442358136177063,
0.14723578095436096,
0.07001418620347977,
0.15535438060760498,
-0.10788463056087494,
0.07785291224718094,
0.2001350373029709,
-0.10715001076459885,
-0.10108868032693863,
0.07859407365322113,
-0.08547011017799377,
-0.25092846155166626,
0.048789478838443756,
0.23254288733005524,
0.024920040741562843,
0.0379754900932312,
-0.11897184699773788,
-0.11134164780378342,
-0.16678501665592194,
0.026846924796700478,
0.015562455169856548,
0.06152375414967537,
0.06467490643262863,
-0.27077677845954895,
0.28021860122680664,
0.2658248841762543,
0.12051088362932205,
0.14798179268836975,
-0.05528942123055458,
0.03146597370505333,
-0.08167330175638199,
0.009922117926180363,
0.004391489550471306,
0.003387161297723651,
-0.0748223289847374,
-0.18103143572807312,
-0.09634578973054886,
-0.22418107092380524,
-0.0006241208175197244,
-0.1061801090836525,
-0.1478416472673416,
-0.14628136157989502,
0.09673203527927399,
0.015417823567986488,
0.008024209178984165,
0.06536581367254257,
-0.04145437479019165,
-0.11192118376493454,
-0.036763157695531845,
0.04229557514190674,
-0.023749960586428642,
0.214756578207016,
-0.01724492758512497,
-0.060213878750801086,
0.21071183681488037,
-0.10469736158847809,
-0.421045184135437,
-0.12723709642887115,
0.0865553468465805,
-0.006801549345254898,
-0.2882784903049469,
0.045806266367435455,
-0.2439248412847519,
0.1303267627954483,
-0.126592755317688,
-0.0008521475829184055,
-0.0013043968938291073,
0.3841739594936371,
0.07484457641839981,
-0.09792160987854004,
-0.2655780613422394,
0.15558701753616333,
-0.03355255350470543,
0.10749596357345581,
-0.2572336494922638,
0.2636861503124237,
-0.23727433383464813,
0.02328687720000744,
0.02264055609703064,
0.3469899892807007,
0.26189976930618286,
-0.014250621199607849,
-0.19348157942295074,
-0.28437840938568115,
-0.14406438171863556,
0.08939430117607117,
-0.37816765904426575,
-0.03563925623893738,
0.09050950407981873,
0.1861114650964737,
0.22747696936130524,
0.17695188522338867,
-0.05398814380168915,
-0.012249280698597431,
-0.04267841577529907,
0.20319248735904694,
-0.072663314640522,
0.15275399386882782,
-0.08095739036798477,
0.2755369544029236,
-0.0504702627658844,
0.26788634061813354,
-0.024494098499417305,
-0.1095791906118393,
0.05133432149887085,
-0.08972211182117462,
-0.16841088235378265,
-0.14378751814365387,
-0.026315512135624886,
-0.015578140504658222,
0.29404115676879883,
0.024709776043891907,
-0.04924912005662918,
-0.09291306138038635,
-0.023886555805802345,
0.16098684072494507,
0.13984884321689606,
-0.23117564618587494,
0.22601504623889923,
-0.23165631294250488,
0.0799989402294159,
-0.1891861855983734,
0.0303936880081892,
-0.30619290471076965,
0.1893567442893982,
-0.18980690836906433,
-0.24587388336658478,
-0.0032377324532717466,
-0.09788653254508972,
0.0035097140353173018,
-0.0770498737692833,
0.11082287132740021,
0.12010903656482697,
0.29260149598121643,
-0.09667834639549255,
-0.015043145976960659,
-0.06959066540002823,
0.24486491084098816,
-0.05160348862409592,
0.1301080882549286,
0.0725158080458641,
0.17754237353801727,
-0.07638411223888397,
-0.05520166829228401,
0.17867307364940643,
0.17096079885959625,
-0.06587774306535721,
0.05962414667010307,
-0.16520945727825165,
-0.20352190732955933,
-0.022183705121278763,
-0.03630838915705681,
0.01597728207707405,
0.030734922736883163,
0.029334330931305885,
-0.10692279785871506,
0.23426200449466705,
-0.12190542370080948,
0.46883532404899597,
-0.01700548641383648,
-0.3592660129070282,
-0.18115897476673126,
-0.037817180156707764,
0.2729826271533966,
0.1350598782300949,
-0.02113036811351776,
-0.12866446375846863,
0.363107293844223,
-0.37342220544815063,
0.1330725997686386,
-0.08018133044242859,
0.17594309151172638,
0.06569954752922058,
0.06678543239831924,
-0.042405154556035995,
0.3900195360183716,
-0.1584792137145996,
-0.28039830923080444,
-0.1710699051618576,
-0.15104013681411743,
0.027019528672099113,
0.11199831962585449,
0.17442551255226135,
-0.06318316608667374,
-0.16708950698375702,
0.19493471086025238,
-0.2374848872423172,
0.10576999187469482,
-0.08568441867828369,
-0.18579798936843872,
-0.17934036254882812,
-0.000172793646925129,
0.1882641315460205,
-0.07450436055660248,
0.14208680391311646,
-0.11948875337839127,
0.13519209623336792,
-0.2039155215024948,
-0.2257051318883896,
0.16674882173538208,
-0.06839688867330551,
-0.05850771814584732,
-0.05451222136616707,
0.05014721304178238,
-0.04486978426575661,
0.01856052689254284,
0.1379564255475998,
-0.03014420159161091,
-0.10872302204370499,
-0.3478993773460388,
-0.08550073951482773,
-0.45279309153556824,
0.16505402326583862,
-0.10484891384840012,
0.1182398647069931,
0.014940960332751274,
0.0006249525467865169,
-0.0955270379781723,
-0.1779497116804123,
-0.29332470893859863,
0.2715597152709961,
0.09124743938446045,
-0.0043770140036940575,
-0.06769277900457382,
0.18618659675121307,
-0.11100081354379654,
-0.08269383758306503,
-0.13640354573726654,
-0.1853819042444229,
0.056158397346735,
0.0993979424238205,
-0.08285900205373764,
0.15858644247055054,
0.05462774261832237,
0.03771721199154854,
-0.19591878354549408,
-0.16227371990680695,
-0.0194577407091856,
0.04490633308887482,
-0.16501151025295258,
-0.016978010535240173,
0.04276391118764877,
0.0882377028465271,
-0.20860251784324646,
0.25184187293052673,
0.2444196492433548,
0.19778332114219666
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. 2. Broomfield et al Metabolic decompensations. Children with PA can develop episodic metabolic decompensations, especially in the first years of life. Acidosis, hyperammonemia, pancreatitis, metabolic stroke, cardiomyopathy, bone marrow suppression, seizures, and encephalopathy can accompany acutely deranged metabolism. These episodes can be life-threatening and are often precipitated by illnesses, infections, surgery, or any stress augmenting catabolism. Infectious complications (e.g., sepsis or bacterial meningitis) often accompany metabolic crises and are the major contributors to mortality . The long-term cognitive outcome of individuals with PA is negatively correlated to the number of metabolic decompensations .Growth. Linear growth delay and deceleration of the head circumference may become evident with age and can be seen in both earlier- and late-onset groups . Failure to thrive may be exacerbated by malnutrition secondary to feeding difficulties, recurrent emesis, excessive protein restriction and potentially iatrogenic amino acid imbalances .Neurologic manifestations include developmental delay, developmental regression | [
-0.049210790544748306,
-0.008207802660763264,
-0.1389903724193573,
-0.1514110267162323,
0.055717360228300095,
-0.04004203528165817,
0.01467232033610344,
-0.21341685950756073,
-0.028684576973319054,
-0.0962902083992958,
0.136873260140419,
-0.043435562402009964,
0.019141443073749542,
0.06558801233768463,
-0.2831767499446869,
0.08001240342855453,
0.03186671808362007,
-0.009686838835477829,
-0.0230591781437397,
-0.09566935896873474,
-0.010005108080804348,
-0.26001638174057007,
-0.07541698962450027,
0.14852586388587952,
0.29110199213027954,
-0.2313438057899475,
0.18235604465007782,
-0.28783872723579407,
0.22210413217544556,
0.0678594708442688,
-0.0013626688160002232,
0.014684205874800682,
0.16658103466033936,
-0.33510929346084595,
0.03092866577208042,
-0.18370456993579865,
-0.06708966195583344,
-0.15669876337051392,
0.008917492814362049,
-0.17222905158996582,
0.06489406526088715,
-0.1077878475189209,
0.18000474572181702,
0.008088432252407074,
0.1564703732728958,
0.01711333356797695,
-0.04455837979912758,
-0.024087298661470413,
-0.14065591990947723,
0.2467723786830902,
0.007889121770858765,
-0.08845052868127823,
-0.31714388728141785,
0.01445375569164753,
0.10777433961629868,
-0.22048601508140564,
-0.18761134147644043,
0.007385966368019581,
-0.1142178624868393,
0.1469317376613617,
0.04220907390117645,
-0.2751261293888092,
-0.2741219997406006,
-0.3593231737613678,
0.14990225434303284,
-0.11918384581804276,
-0.10123483091592789,
0.18746580183506012,
0.19623202085494995,
-0.20952919125556946,
0.11537227779626846,
-0.0975324884057045,
-0.12750178575515747,
0.24511219561100006,
-0.034524545073509216,
-0.06283044815063477,
0.1175018921494484,
-0.08355556428432465,
-0.04289006069302559,
-0.3312928080558777,
-0.23032833635807037,
0.030453858897089958,
-0.0501602478325367,
-0.2629134953022003,
-0.16180667281150818,
0.09423694014549255,
0.18712128698825836,
0.0016701002605259418,
0.04041922837495804,
0.15992791950702667,
0.030155407264828682,
0.01249695010483265,
-0.14937104284763336,
0.023082489147782326,
0.013261896558105946,
0.017643773928284645,
0.01762937754392624,
0.03761380910873413,
-0.12123248726129532,
0.18614819645881653,
0.06143451854586601,
0.10729490965604782,
-0.1580004245042801,
0.03292899578809738,
0.004538448993116617,
0.10426204651594162,
-0.11883474886417389,
-0.013527766801416874,
-0.09331270307302475,
0.05328425019979477,
0.04305827617645264,
-0.21641670167446136,
0.16123512387275696,
0.07921773195266724,
-0.556692898273468,
0.0074688708409667015,
-0.16692012548446655,
0.2266424000263214,
0.12945210933685303,
-0.1420718878507614,
-0.0036211321130394936,
0.19607007503509521,
0.09607916325330734,
0.056890979409217834,
0.11669963598251343,
0.012866664677858353,
0.08938369899988174,
0.00620803888887167,
0.17598767578601837,
-0.016906779259443283,
0.09611809253692627,
-0.05624885484576225,
0.004266120493412018,
-0.2602350413799286,
0.1994120478630066,
-0.05361846834421158,
-0.3600561022758484,
-0.31660404801368713,
-0.011579836718738079,
0.006133108399808407,
0.21308568120002747,
0.2213485687971115,
0.13773715496063232,
0.21599899232387543,
0.1848229169845581,
0.0988466739654541,
0.3668777346611023,
0.06372986733913422,
0.1060430258512497,
0.010482392273843288,
-0.03363771736621857,
-0.1989365518093109,
0.11830224096775055,
-0.2065882533788681,
-0.1577606350183487,
0.18678238987922668,
-0.005244438070803881,
0.22725309431552887,
-0.12471383064985275,
0.034475523978471756,
-0.0965658649802208,
0.021686391904950142,
-0.045734748244285583,
0.09505544602870941,
-0.2320469468832016,
0.10542890429496765,
-0.32092970609664917,
0.06865690648555756,
-0.05166381224989891,
-0.1666928082704544,
-0.03001382388174534,
-0.053245916962623596,
-0.043292924761772156,
0.0996723473072052,
0.03292035683989525,
-0.013430391438305378,
-0.1611744463443756,
-0.012781420722603798,
-0.07643605023622513,
0.2474411278963089,
0.1488039344549179,
-0.12356835603713989,
-0.3666051924228668,
0.0006399315898306668,
-0.08903080970048904,
-0.07590705901384354,
0.23287399113178253,
0.21418800950050354,
-0.01769096963107586,
0.21788500249385834,
0.1840590536594391,
0.1245293840765953,
0.05770539864897728,
0.10187510401010513,
-0.054787617176771164,
-0.19931159913539886,
0.10685443133115768,
0.028198223561048508,
-0.08312582224607468,
-0.007480335421860218,
-0.14772391319274902,
-0.16488781571388245,
0.204065203666687,
-0.12154272198677063,
-0.15008185803890228,
-0.024223212152719498,
0.05521082133054733,
-0.004956169053912163,
0.12441066652536392,
0.07192297279834747,
-0.19906100630760193,
0.21844659745693207,
-0.12090930342674255,
-0.08176150918006897,
-0.268955796957016,
-0.10133279860019684,
-0.04506533965468407,
-0.05901744216680527,
-0.06885948032140732,
0.010993624106049538,
-0.016918927431106567,
-0.144014373421669,
0.010059007443487644,
-0.17174804210662842,
-0.1452757567167282,
-0.15759693086147308,
-0.3104633390903473,
-0.1484968662261963,
0.07259917259216309,
-0.19815805554389954,
-0.26998794078826904,
0.18148337304592133,
-0.01187901571393013,
0.2665684223175049,
-0.03005255199968815,
-0.14507494866847992,
-0.19561302661895752,
0.2628870904445648,
-0.22051259875297546,
-0.07326780259609222,
-0.5455402731895447,
0.03412317484617233,
0.06957166641950607,
-0.004275704734027386,
-0.0280467476695776,
0.15799011290073395,
-0.024558085948228836,
0.17487609386444092,
-0.0037356894463300705,
0.1542043536901474,
-0.06711089611053467,
0.013186564669013023,
-0.013936495408415794,
0.1091454029083252,
-0.3983675539493561,
-0.20018216967582703,
0.2173047661781311,
-0.0478484220802784,
-0.027281641960144043,
-0.11189452558755875,
-0.19788888096809387,
0.21821530163288116,
0.11539897322654724,
0.13991720974445343,
0.011645698919892311,
-0.11162932217121124,
-0.18007594347000122,
0.11998064815998077,
-0.026209622621536255,
-0.24414531886577606,
-0.07279627025127411,
0.21867665648460388,
0.140027716755867,
0.10014012455940247,
-0.3571872413158417,
-0.15213897824287415,
0.14904671907424927,
0.12579628825187683,
0.14540955424308777,
-0.03329385444521904,
-0.08610410243272781,
0.2288166880607605,
0.08944722265005112,
0.06255973875522614,
0.12422526627779007,
0.10503635555505753,
0.010690884664654732,
0.00820658914744854,
-0.028371743857860565,
0.09366825222969055,
-0.030615728348493576,
0.2284156084060669,
0.0018005365272983909,
0.024083105847239494,
0.09863533079624176,
0.1396521031856537,
-0.09981406480073929,
-0.010860537178814411,
-0.0402035266160965,
0.03277703374624252,
-0.061846088618040085,
0.16105884313583374,
0.18168388307094574,
0.11892557889223099,
-0.3643273115158081,
-0.01751270890235901,
-0.09062834084033966,
0.034372247755527496,
-0.01571188122034073,
0.3193260729312897,
-0.11434643715620041,
-0.2489510327577591,
-0.08867701888084412,
-0.0053115347400307655,
-0.18881329894065857,
-0.043034352362155914,
-0.009082064032554626,
0.23626142740249634,
0.15690666437149048,
0.26334500312805176,
0.015696173533797264,
-0.01181537751108408,
0.1510666012763977,
0.051036663353443146,
-0.16541151702404022,
-0.08676813542842865,
0.003160713007673621,
0.1298299878835678,
0.006276697386056185,
0.03797836974263191,
0.04806005582213402,
0.16894574463367462,
0.08211914449930191,
-0.1626250445842743,
0.12095452845096588,
-0.22419185936450958,
0.287773996591568,
0.030011214315891266,
-0.14853745698928833,
0.11124848574399948,
0.17780469357967377,
-0.4894700348377228,
0.010540970601141453,
-0.2954166531562805,
-0.25388625264167786,
0.18123888969421387,
-0.10356442630290985,
0.15023235976696014,
0.14913320541381836,
0.04006374254822731,
-0.0881577581167221,
0.09921868145465851,
-0.11281942576169968,
-0.19021402299404144,
0.23838624358177185,
-0.1083209291100502,
-0.13611429929733276,
0.12831972539424896,
0.12016817182302475,
0.13027231395244598,
-0.304162859916687,
0.08658459782600403,
0.053118620067834854,
-0.23738838732242584,
0.042815059423446655,
-0.24398091435432434,
-0.1898813396692276,
-0.05085650831460953,
0.13001620769500732,
-0.11457125842571259,
0.028301198035478592,
0.1832963526248932,
0.05306810513138771,
0.05222455784678459,
-0.0333208404481411,
0.03810758516192436,
-0.08981694281101227,
-0.012071692384779453,
-0.4096260666847229,
-0.15487493574619293,
0.0551508329808712,
-0.0641116201877594,
0.10641249269247055,
-0.09788847714662552,
0.03864613175392151,
0.007844116538763046,
-0.08232525736093521,
0.24810096621513367,
0.23920683562755585,
-0.5740415453910828,
-0.009225437417626381,
0.23884905874729156,
-0.006931109353899956,
0.21961933374404907,
0.14326050877571106,
0.15374909341335297,
0.044974587857723236,
0.1507309377193451,
-0.1510152965784073,
0.11141107976436615,
0.025709131732583046,
0.05900689959526062,
0.3202821910381317,
0.10872672498226166,
0.14445732533931732,
0.09531155973672867,
0.05326628312468529,
0.15868720412254333,
-0.12567999958992004,
0.18330854177474976,
-0.11136631667613983,
-0.10923536121845245,
0.020660126581788063,
-0.17062492668628693,
-0.07313612103462219,
-0.04583428427577019,
-0.17333917319774628,
0.06704005599021912,
0.22514131665229797,
-0.1350221186876297,
-0.17917737364768982,
-0.06336600333452225,
0.1483784317970276,
-0.04668093100190163,
-0.22226546704769135,
0.0831167921423912,
0.06367366760969162,
-0.13027092814445496,
0.11654102057218552,
0.13136379420757294,
0.16386640071868896,
-0.01525725144892931,
-0.03134557977318764,
0.17044489085674286,
0.15547572076320648,
0.10197659581899643,
-0.23405982553958893,
0.1280919760465622,
-0.04948470741510391,
-0.17878840863704681,
0.12068524956703186,
-0.05215106159448624,
-0.02143380045890808,
0.1008118987083435,
-0.09030526876449585,
0.2265651822090149,
0.04049909487366676,
0.19896091520786285,
-0.1062079519033432,
0.15691229701042175,
0.13983702659606934,
-0.12216562032699585,
0.0018246808322146535,
0.07006606459617615,
0.14203417301177979,
0.0782083198428154,
0.019380725920200348,
-0.10108086466789246,
0.07509535551071167,
-0.04600062593817711,
-0.24260109663009644,
0.10310743749141693,
0.31718260049819946,
-0.13670293986797333,
-0.23819638788700104,
0.09653785824775696,
-0.24094322323799133,
0.12849535048007965,
-0.09487291425466537,
0.12921948730945587,
0.03193425387144089,
0.12528787553310394,
-0.10635722428560257,
0.06522428244352341,
-0.11133980005979538,
-0.11372139304876328,
0.017055753618478775,
-0.027333645150065422,
-0.12025652825832367,
0.11609926074743271,
-0.04631568491458893,
-0.14348502457141876,
0.08312850445508957,
-0.01531792152673006,
-0.10579124093055725,
0.10076016187667847,
-0.36267518997192383,
0.21597136557102203,
0.25530266761779785,
-0.08647824823856354,
0.03128109872341156,
-0.031810540705919266,
-0.11151604354381561,
0.4957493543624878,
-0.09664458781480789,
-0.24882015585899353,
-0.05595032498240471,
-0.2281494289636612,
0.019706133753061295,
0.07153884321451187,
-0.058874521404504776,
-0.08959809690713882,
-0.19919359683990479,
-0.021048542112112045,
-0.00932302512228489,
0.05286649242043495,
0.018937431275844574,
-0.22550241649150848,
-0.146192729473114,
0.1477205753326416,
0.06873743236064911,
0.10885296761989594,
-0.09673735499382019,
0.015452183783054352,
0.08813641220331192,
-0.20953211188316345,
0.23732368648052216,
0.2454204112291336,
0.03381472826004028,
-0.19502678513526917,
0.17834101617336273,
0.07283953577280045,
0.09229209274053574,
0.03820199519395828,
0.07143190503120422,
-0.02596532180905342,
0.030372237786650658,
0.10582458972930908,
-0.1788717657327652,
-0.060035496950149536,
0.08211681246757507,
-0.08234918117523193,
-0.11779756098985672,
0.04249068349599838,
0.26411566138267517,
-0.0873902216553688,
-0.010695220902562141,
-0.16668656468391418,
-0.07483405619859695,
-0.15895813703536987,
0.06070146709680557,
0.08852916210889816,
-0.10992459952831268,
0.06690437346696854,
-0.3462323248386383,
0.23436880111694336,
0.2494981288909912,
0.13439713418483734,
0.04542349651455879,
-0.15453870594501495,
0.02952600084245205,
-0.0754065290093422,
0.002414947608485818,
0.021076487377285957,
-0.011439133435487747,
-0.0788852721452713,
-0.1832091212272644,
-0.09065549820661545,
-0.12414367496967316,
0.08567216992378235,
-0.13712118566036224,
-0.0811246857047081,
-0.11111006885766983,
0.025009803473949432,
0.03548843413591385,
0.18819119036197662,
0.0381438247859478,
-0.02787395380437374,
-0.0020019076764583588,
-0.018879707902669907,
0.10407598316669464,
0.00778398709371686,
0.1392313539981842,
-0.01157374493777752,
-0.00917204562574625,
0.10657644271850586,
-0.08258834481239319,
-0.39540424942970276,
-0.12520436942577362,
0.019481368362903595,
0.027283798903226852,
-0.17389868199825287,
0.08891528099775314,
-0.263119637966156,
0.023030836135149002,
-0.07499890774488449,
0.07589344680309296,
-0.044865213334560394,
0.46145516633987427,
0.1210884377360344,
-0.07068147510290146,
-0.20207622647285461,
0.1407843828201294,
-0.02473483793437481,
0.05478702485561371,
-0.31883662939071655,
0.3123437166213989,
-0.30494624376296997,
-0.013657031580805779,
0.06707634031772614,
0.39682891964912415,
0.2618512809276581,
0.11174905300140381,
-0.1418589949607849,
-0.212876096367836,
-0.17321564257144928,
0.1423099786043167,
-0.3426208794116974,
-0.07769089937210083,
0.06748807430267334,
0.08312920480966568,
0.21827971935272217,
0.17314022779464722,
0.010158763267099857,
-0.03475114703178406,
-0.1455470323562622,
0.16161416471004486,
-0.04689357802271843,
0.14393137395381927,
-0.032819125801324844,
0.22718676924705505,
0.0414908193051815,
0.20028990507125854,
-0.03193766623735428,
-0.13675446808338165,
0.10080789029598236,
-0.14768627285957336,
-0.06861749291419983,
-0.06956204026937485,
-0.000003691935717142769,
0.004837212152779102,
0.2714785933494568,
0.03782563656568527,
-0.022857755422592163,
-0.09573249518871307,
-0.03696369752287865,
0.2123260647058487,
0.14701205492019653,
-0.2695598304271698,
0.12578904628753662,
-0.2941429913043976,
0.10029134899377823,
-0.032069239765405655,
0.08714469522237778,
-0.15831860899925232,
0.23250116407871246,
-0.18373967707157135,
-0.19198542833328247,
-0.10532727837562561,
-0.12688545882701874,
0.07755447179079056,
-0.10062713921070099,
0.08526723831892014,
0.11021345853805542,
0.24677018821239471,
-0.0731690526008606,
-0.059065382927656174,
-0.1386352926492691,
0.30135512351989746,
-0.07331658154726028,
0.07894297689199448,
0.13223768770694733,
0.07887328416109085,
-0.06310708820819855,
-0.11663864552974701,
0.15439754724502563,
0.1701495498418808,
-0.07033392041921616,
0.11430758982896805,
-0.15075574815273285,
-0.25603222846984863,
0.013373731635510921,
-0.17631316184997559,
-0.002284448128193617,
-0.0287578534334898,
0.01334336306899786,
-0.02232740819454193,
0.18902915716171265,
-0.17164215445518494,
0.41251644492149353,
-0.00287447776645422,
-0.35358646512031555,
-0.1834876984357834,
-0.07610802352428436,
0.24233129620552063,
0.1284681260585785,
-0.047149188816547394,
-0.15193304419517517,
0.32292836904525757,
-0.3233341574668884,
0.14042408764362335,
0.04401669651269913,
0.14114804565906525,
0.09704508632421494,
0.01430902723222971,
-0.13398082554340363,
0.3151107430458069,
-0.09292972832918167,
-0.2577877640724182,
-0.08140624314546585,
-0.14336660504341125,
-0.020608024671673775,
-0.0414418950676918,
0.10455572605133057,
-0.08987803757190704,
-0.09666566550731659,
0.15023881196975708,
-0.25908559560775757,
0.08667126297950745,
-0.21815872192382812,
-0.15935967862606049,
-0.22314801812171936,
-0.0660686120390892,
0.23719966411590576,
0.013564220629632473,
0.11994490027427673,
-0.06412193179130554,
0.12790459394454956,
-0.1783503144979477,
-0.2647929787635803,
0.10358269512653351,
-0.0032048067077994347,
-0.07724794000387192,
-0.02731260284781456,
0.07021389901638031,
-0.09520985931158066,
0.016853729262948036,
0.22279581427574158,
0.024370232596993446,
-0.06202492117881775,
-0.2629074454307556,
-0.06984976679086685,
-0.3392076790332794,
0.10354197025299072,
-0.010541599243879318,
0.04119739308953285,
0.02816135436296463,
-0.07784751802682877,
-0.029219795018434525,
-0.14411912858486176,
-0.21804843842983246,
0.23719361424446106,
0.15806664526462555,
-0.059550680220127106,
-0.059190649539232254,
0.16775871813297272,
-0.12284636497497559,
-0.08325470983982086,
-0.0662350207567215,
-0.16783037781715393,
0.08095958083868027,
0.03210940584540367,
-0.07736403495073318,
0.16082794964313507,
0.03589976206421852,
0.01489063911139965,
-0.2138596773147583,
-0.28736329078674316,
-0.0033554290421307087,
0.026523275300860405,
-0.05562638118863106,
-0.06790975481271744,
-0.02021041326224804,
0.14294882118701935,
-0.142897829413414,
0.19791142642498016,
0.10678169876337051,
0.15461331605911255
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. often accompany metabolic crises and are the major contributors to mortality . The long-term cognitive outcome of individuals with PA is negatively correlated to the number of metabolic decompensations .Growth. Linear growth delay and deceleration of the head circumference may become evident with age and can be seen in both earlier- and late-onset groups . Failure to thrive may be exacerbated by malnutrition secondary to feeding difficulties, recurrent emesis, excessive protein restriction and potentially iatrogenic amino acid imbalances .Neurologic manifestations include developmental delay, developmental regression, intellectual disability, seizures, hypotonia, spasticity, and movement disorders . Developmental delays and neurologic dysfunction can be seen even in individuals without documented episodes of hyperammonemia or ketoacidosis . The prevalence of intellectual disability can vary between approximately 35% and 76% depending on the reported cohort .Seizures were reported in 13%-53% and EEG abnormalities in 40%-63% of Individuals with PA. Reported forms of seizures included infantile spasms, tonic-clonic, | [
-0.001363010029308498,
-0.02333120070397854,
-0.15942369401454926,
-0.14769352972507477,
0.025217987596988678,
-0.041295379400253296,
0.07077688723802567,
-0.17806647717952728,
-0.054365482181310654,
-0.033864207565784454,
0.029512012377381325,
-0.036392681300640106,
-0.04465094208717346,
0.0856688991189003,
-0.3824101388454437,
0.01586511917412281,
0.11420601606369019,
-0.07707560062408447,
-0.09003521502017975,
-0.2097548246383667,
-0.07535167783498764,
-0.15777777135372162,
-0.05525236576795578,
0.13882558047771454,
0.24981476366519928,
-0.22269411385059357,
0.1581469476222992,
-0.23218484222888947,
0.30313438177108765,
0.10603644698858261,
-0.040251411497592926,
0.07604192942380905,
0.26813748478889465,
-0.3797813653945923,
-0.03998620808124542,
-0.18952587246894836,
-0.10136830061674118,
-0.21843969821929932,
0.07168442755937576,
-0.283397912979126,
0.1087922528386116,
-0.1617959886789322,
0.16462911665439606,
-0.055172696709632874,
0.2021380364894867,
-0.011755154468119144,
-0.18304328620433807,
-0.06295133382081985,
-0.20310096442699432,
0.1863330751657486,
0.0639243870973587,
-0.10129453241825104,
-0.2794317603111267,
0.06583376228809357,
0.023006994277238846,
-0.2566052973270416,
-0.1109330877661705,
0.10577234625816345,
-0.21441633999347687,
0.19511057436466217,
0.157198965549469,
-0.2059210240840912,
-0.2222525030374527,
-0.331521213054657,
0.1345353126525879,
-0.15689510107040405,
-0.10591157525777817,
0.22849464416503906,
0.16099713742733002,
-0.23354007303714752,
0.07608405500650406,
-0.15575450658798218,
-0.09036323428153992,
0.22100815176963806,
-0.14281538128852844,
-0.02311210334300995,
0.10701912641525269,
-0.004481729120016098,
-0.040578313171863556,
-0.30172187089920044,
-0.23492975533008575,
0.012047607451677322,
-0.05592967942357063,
-0.329750120639801,
-0.08374875783920288,
0.08014000207185745,
0.15919600427150726,
-0.045367639511823654,
0.026290155947208405,
0.10002802312374115,
0.1599394977092743,
0.0019742255099117756,
-0.19099336862564087,
-0.04824810475111008,
0.11616893112659454,
0.049636926501989365,
0.13661424815654755,
-0.0306012574583292,
-0.23689822852611542,
0.033278364688158035,
0.0036594646517187357,
0.13036717474460602,
-0.10097545385360718,
0.10628261417150497,
-0.12360922247171402,
0.12048143148422241,
-0.14257965981960297,
-0.029506683349609375,
0.0010937814367935061,
0.05532634258270264,
0.03307495266199112,
-0.2978845536708832,
0.19316616654396057,
-0.06349218636751175,
-0.5604942440986633,
-0.03571116924285889,
-0.20646721124649048,
0.3337429165840149,
0.11943253874778748,
-0.06595993787050247,
0.05997218191623688,
0.058517009019851685,
0.04426901414990425,
0.0675094723701477,
0.0700153335928917,
0.03731805831193924,
0.1432034969329834,
0.042010072618722916,
0.21152950823307037,
-0.0021175318397581577,
0.11812961101531982,
-0.06990722566843033,
0.0014715446159243584,
-0.17428739368915558,
0.17595835030078888,
0.0011508852476254106,
-0.40694740414619446,
-0.38674432039260864,
-0.09942199289798737,
-0.04557965323328972,
0.06210005655884743,
0.05619468167424202,
0.15560638904571533,
0.16266962885856628,
0.3838959336280823,
0.06604394316673279,
0.2847989797592163,
0.09477604180574417,
0.1027861014008522,
0.010304118506610394,
-0.10100778192281723,
-0.15322823822498322,
0.1625077724456787,
-0.048805177211761475,
-0.13539652526378632,
0.16547992825508118,
0.014859296381473541,
0.24168702960014343,
-0.015558885410428047,
0.04164057597517967,
-0.198261559009552,
-0.04887896031141281,
-0.1733177751302719,
0.02931123785674572,
-0.22203506529331207,
-0.012186757288873196,
-0.39906224608421326,
-0.022713959217071533,
-0.03566574305295944,
-0.18548327684402466,
-0.037124309688806534,
0.02648845873773098,
-0.07410851120948792,
0.1031753271818161,
0.03825360909104347,
-0.06585685163736343,
-0.03660328686237335,
0.11097731441259384,
-0.1100735142827034,
0.23614250123500824,
0.27824920415878296,
-0.1312401443719864,
-0.3868832290172577,
0.03064136579632759,
-0.11258522421121597,
-0.1472984105348587,
0.1428862363100052,
0.2882899045944214,
0.005934875458478928,
0.11397221684455872,
0.1991177201271057,
0.11366302520036697,
0.04511483758687973,
0.1337713897228241,
0.002183040603995323,
-0.2466599941253662,
0.13801521062850952,
-0.06812438368797302,
-0.06991841644048691,
0.0848851427435875,
-0.12141729891300201,
-0.09506253153085709,
0.2614748775959015,
-0.05218971148133278,
-0.1161356121301651,
-0.0678349956870079,
0.0588449127972126,
-0.018016107380390167,
0.07660384476184845,
0.24111492931842804,
-0.15829218924045563,
0.30947092175483704,
-0.08093522489070892,
-0.09187167137861252,
-0.1577787697315216,
-0.0770566388964653,
-0.04841097816824913,
0.014665801078081131,
-0.00391163257881999,
0.13123559951782227,
0.1327318549156189,
0.04664654657244682,
0.014799841679632664,
-0.17878586053848267,
-0.055279675871133804,
0.00048436594079248607,
-0.39310356974601746,
-0.19847653806209564,
0.07925087213516235,
-0.18529613316059113,
-0.3292078673839569,
0.196580171585083,
-0.09591138362884521,
0.22196203470230103,
0.009178086183965206,
-0.28355273604393005,
-0.21896782517433167,
0.25320062041282654,
-0.18496863543987274,
0.011959116905927658,
-0.5180098414421082,
-0.05075262486934662,
-0.007263761945068836,
-0.11752241849899292,
-0.15089823305606842,
0.10166950523853302,
0.005099677015095949,
0.06544270366430283,
0.004005777649581432,
0.17749808728694916,
-0.0684729591012001,
0.05930672958493233,
0.07707856595516205,
0.11605627834796906,
-0.3725675940513611,
-0.15193352103233337,
0.15485237538814545,
-0.047082576900720596,
-0.010547126643359661,
-0.04039900004863739,
-0.12536785006523132,
0.2360246330499649,
0.06096973270177841,
0.01266456302255392,
-0.045905210077762604,
-0.12843860685825348,
-0.1079183965921402,
0.11301863193511963,
0.026911767199635506,
-0.2998926043510437,
-0.02118018828332424,
0.15737907588481903,
0.17994554340839386,
0.03614562377333641,
-0.2586043179035187,
-0.18761838972568512,
0.13401266932487488,
0.037116002291440964,
0.128239244222641,
-0.043374285101890564,
-0.055709656327962875,
0.1585206687450409,
0.03465500473976135,
-0.002438278403133154,
0.26425471901893616,
0.08525603264570236,
0.06933639943599701,
0.05780003219842911,
-0.05474404990673065,
0.04610052332282066,
0.0139117781072855,
0.30396029353141785,
-0.009342784062027931,
-0.025792432948946953,
0.0859832763671875,
0.20244258642196655,
-0.050484076142311096,
0.002484907628968358,
-0.040574003010988235,
0.05410049483180046,
0.023070966824889183,
0.15248455107212067,
0.2735326588153839,
0.13677465915679932,
-0.3526488244533539,
-0.05052144080400467,
-0.010818599723279476,
-0.04412365332245827,
-0.006388677749782801,
0.28644925355911255,
-0.07881907373666763,
-0.31038302183151245,
0.010234067216515541,
0.025173434987664223,
-0.1592019945383072,
-0.0071002887561917305,
0.09833936393260956,
0.19914662837982178,
0.11726855486631393,
0.2544315457344055,
-0.05991871654987335,
0.09504687041044235,
0.10714231431484222,
0.10718390345573425,
-0.17734143137931824,
-0.012630031444132328,
-0.08578135818243027,
0.10424884408712387,
-0.025589633733034134,
0.12341004610061646,
-0.18874797224998474,
0.25517043471336365,
-0.00780213950201869,
-0.23070427775382996,
0.18256442248821259,
-0.18415772914886475,
0.43277353048324585,
0.022176949307322502,
-0.17307481169700623,
0.039658453315496445,
0.15736208856105804,
-0.46915411949157715,
-0.09682328253984451,
-0.2707323431968689,
-0.30644774436950684,
0.06856154650449753,
-0.20118145644664764,
0.34660854935646057,
0.10534640401601791,
0.007229524664580822,
-0.018152514472603798,
0.13902491331100464,
-0.20614753663539886,
-0.17310193181037903,
0.1160024106502533,
-0.05919896811246872,
-0.09838087111711502,
0.06305377930402756,
0.1380133181810379,
0.07644051313400269,
-0.3797261118888855,
0.001808146364055574,
0.08464277535676956,
-0.13168637454509735,
0.10104037821292877,
-0.2620561718940735,
-0.1407276690006256,
-0.03773372992873192,
0.21191410720348358,
-0.11454035341739655,
0.06419487297534943,
0.13467402756214142,
-0.021191291511058807,
0.054272573441267014,
-0.04959435015916824,
0.18110984563827515,
-0.11969751864671707,
0.03564312681555748,
-0.4101755619049072,
-0.1706867218017578,
0.13444265723228455,
-0.05688561499118805,
0.03809676691889763,
-0.009592500515282154,
0.03627070412039757,
0.053022511303424835,
-0.14854153990745544,
0.3516716957092285,
0.27872714400291443,
-0.5957723259925842,
0.08963220566511154,
0.20241375267505646,
-0.008764822967350483,
0.30200907588005066,
0.12878373265266418,
0.14353252947330475,
0.0589393712580204,
0.14776985347270966,
-0.12757855653762817,
0.03170923516154289,
0.08817173540592194,
0.003116563195362687,
0.2700158953666687,
0.10206726938486099,
0.24657168984413147,
0.12711210548877716,
0.09008293598890305,
0.08620651066303253,
-0.2053615301847458,
0.0836661159992218,
-0.08524449169635773,
-0.23745715618133545,
0.01652316376566887,
-0.0579606257379055,
-0.13069887459278107,
-0.06947530061006546,
-0.1320684403181076,
0.06589707732200623,
0.18529470264911652,
-0.10142766684293747,
-0.17229191958904266,
-0.1178203895688057,
0.09224376827478409,
0.06459467858076096,
-0.15884922444820404,
0.13865648210048676,
0.09763550758361816,
-0.10806340724229813,
0.04662726819515228,
0.060154031962156296,
0.16207614541053772,
0.022704748436808586,
0.019810950383543968,
0.06288264691829681,
0.0773216113448143,
0.17043469846248627,
-0.21784880757331848,
-0.0006238817586563528,
-0.07173105329275131,
-0.0924520492553711,
0.032749541103839874,
-0.08746255934238434,
-0.053365305066108704,
-0.026147501543164253,
-0.10755626112222672,
0.22595487534999847,
0.16300947964191437,
0.14821326732635498,
-0.10004782676696777,
0.033508822321891785,
0.11351633816957474,
-0.10003768652677536,
0.04246632009744644,
0.025850774720311165,
0.11516023427248001,
0.10172519832849503,
0.12351284921169281,
-0.06117725744843483,
0.01900392770767212,
-0.05472331866621971,
-0.21796083450317383,
0.10989212989807129,
0.3015255331993103,
-0.2263689786195755,
-0.16680260002613068,
0.1484014093875885,
-0.13136576116085052,
0.15038327872753143,
-0.02958197519183159,
0.10840818285942078,
0.02238716371357441,
0.16086556017398834,
-0.1527433544397354,
0.0025019568856805563,
-0.1582777202129364,
-0.14992985129356384,
-0.08394835889339447,
0.07487878948450089,
-0.07567641884088516,
0.13794353604316711,
-0.09227260202169418,
-0.08113615214824677,
0.17786014080047607,
0.09061215817928314,
-0.21931223571300507,
0.20565026998519897,
-0.3116937577724457,
0.19780521094799042,
0.3542783558368683,
-0.09242594987154007,
0.022166993468999863,
-0.07189822196960449,
-0.05888408049941063,
0.34501543641090393,
-0.14565639197826385,
-0.3492242097854614,
0.0612524151802063,
-0.05419529974460602,
0.02532634139060974,
0.03487761691212654,
-0.042242616415023804,
-0.161854550242424,
-0.2654191851615906,
-0.04265935719013214,
0.012750965543091297,
0.03806078061461449,
-0.01588905043900013,
-0.19435647130012512,
-0.09485642611980438,
0.21779559552669525,
0.14901918172836304,
0.1406567245721817,
-0.028516992926597595,
-0.12265155464410782,
0.09780613332986832,
-0.26046642661094666,
0.24074532091617584,
0.28095924854278564,
0.10343249887228012,
-0.26709526777267456,
0.1960766464471817,
0.06686011701822281,
0.1648259311914444,
-0.015163009986281395,
0.11465492844581604,
-0.11765667051076889,
0.06777733564376831,
0.08074410259723663,
-0.14028482139110565,
-0.23200811445713043,
0.07991325110197067,
-0.035457298159599304,
-0.11574400961399078,
0.08202002942562103,
0.15482990443706512,
-0.12811140716075897,
0.018102968111634254,
-0.22193869948387146,
0.03966224566102028,
-0.23872010409832,
-0.026107827201485634,
0.09243224561214447,
-0.2005937397480011,
0.011772357858717442,
-0.2552447021007538,
0.21743372082710266,
0.2946436405181885,
0.17843613028526306,
0.17606106400489807,
-0.0729033350944519,
0.004112597554922104,
-0.14641965925693512,
-0.006289523094892502,
0.04093753173947334,
-0.023641984909772873,
-0.03745333105325699,
-0.1896224021911621,
-0.21274766325950623,
-0.16911807656288147,
0.02430669218301773,
-0.10224080830812454,
0.030923645943403244,
-0.15982991456985474,
0.1112711951136589,
-0.12227188050746918,
0.13563260436058044,
0.09537601470947266,
0.02153059095144272,
-0.024440893903374672,
-0.045858852565288544,
0.098267562687397,
-0.05733771249651909,
0.13007524609565735,
-0.008960387669503689,
-0.07555432617664337,
0.09059645235538483,
-0.026151476427912712,
-0.45490339398384094,
-0.14246700704097748,
0.13861790299415588,
0.05992072448134422,
-0.1244375929236412,
0.13928984105587006,
-0.3782367706298828,
0.024124106392264366,
-0.03403575345873833,
0.054656706750392914,
-0.03816932812333107,
0.42658188939094543,
0.0619533471763134,
-0.027668021619319916,
-0.13157004117965698,
0.13438811898231506,
0.04024108499288559,
0.09030235558748245,
-0.25138357281684875,
0.2933723032474518,
-0.2840365171432495,
0.10746902972459793,
0.2114565223455429,
0.3973250091075897,
0.21160580217838287,
0.07170350104570389,
-0.02888619527220726,
-0.10352873802185059,
-0.03266224265098572,
0.1547442227602005,
-0.28291159868240356,
-0.18594257533550262,
0.16022402048110962,
0.19116473197937012,
0.22140754759311676,
0.1107146292924881,
-0.11355967819690704,
0.027011020109057426,
-0.15156316757202148,
0.119081050157547,
-0.030704181641340256,
0.1120695173740387,
0.016594521701335907,
0.2366323322057724,
0.025905419141054153,
0.12176444381475449,
-0.08705302327871323,
-0.1768268644809723,
0.06921348720788956,
-0.05341901630163193,
-0.10054172575473785,
0.053143903613090515,
0.014230807311832905,
0.18187345564365387,
0.33722421526908875,
0.13373558223247528,
-0.006329371593892574,
-0.11921810358762741,
0.0038533678743988276,
0.20642076432704926,
0.24520297348499298,
-0.1603107452392578,
0.21678029000759125,
-0.3567323386669159,
0.007201150991022587,
-0.03659765049815178,
0.12517036497592926,
-0.22585120797157288,
0.11482574045658112,
-0.24991865456104279,
-0.21464762091636658,
-0.1038128137588501,
-0.20438680052757263,
0.12383757531642914,
-0.13012947142124176,
-0.07470273226499557,
0.14986830949783325,
0.25692516565322876,
-0.16495288908481598,
-0.14489324390888214,
-0.10669435560703278,
0.18215063214302063,
-0.04157280921936035,
0.05068255960941315,
0.18853607773780823,
0.027578935027122498,
-0.06354621052742004,
-0.25549447536468506,
0.08849533647298813,
0.10117894411087036,
-0.17868386209011078,
0.13845917582511902,
-0.18264716863632202,
-0.3427717685699463,
0.05677244812250137,
-0.08429072797298431,
0.056737493723630905,
0.01633342169225216,
0.04567345604300499,
0.0666511282324791,
0.05953502655029297,
-0.17083005607128143,
0.38399064540863037,
0.0037760231643915176,
-0.30972227454185486,
-0.14394614100456238,
0.012381021864712238,
0.22959522902965546,
0.22191011905670166,
0.014662258327007294,
-0.07283486425876617,
0.2004196047782898,
-0.4462963938713074,
0.2034260332584381,
0.001148862298578024,
0.16956982016563416,
0.10921788215637207,
-0.1082974448800087,
-0.12669719755649567,
0.3901897072792053,
-0.16451051831245422,
-0.25174397230148315,
-0.07521168887615204,
-0.2543638348579407,
0.11343801021575928,
-0.002938890131190419,
0.11135689169168472,
-0.10473081469535828,
-0.08895310759544373,
0.18344949185848236,
-0.058485597372055054,
0.06683233380317688,
-0.23482854664325714,
-0.01868445798754692,
-0.18301256000995636,
-0.05158079043030739,
0.2737429141998291,
-0.014574932865798473,
0.1412322074174881,
-0.08722414076328278,
0.20531272888183594,
-0.17203564941883087,
-0.3531566262245178,
0.0875362902879715,
0.008250242099165916,
0.02889426425099373,
-0.004385467153042555,
-0.05481669679284096,
-0.11624616384506226,
-0.00021455762907862663,
0.2701781690120697,
0.08167298138141632,
0.01641073077917099,
-0.2938477694988251,
-0.022975219413638115,
-0.32385292649269104,
0.15610365569591522,
-0.040250618010759354,
-0.06576685607433319,
-0.014441411942243576,
-0.05610865354537964,
-0.0483904629945755,
-0.14258429408073425,
-0.1309087723493576,
0.31927913427352905,
0.13517306745052338,
-0.001552569679915905,
-0.11294936388731003,
0.178186297416687,
0.015670159831643105,
-0.07819635421037674,
0.038717202842235565,
-0.14714762568473816,
0.0754193440079689,
0.07949791103601456,
0.041347481310367584,
0.09420827776193619,
0.1222924292087555,
-0.0018770764581859112,
-0.16530871391296387,
-0.22723636031150818,
0.04326365515589714,
-0.13333113491535187,
-0.05956217274069786,
-0.015375975519418716,
-0.11300229281187057,
0.2139470875263214,
-0.18301527202129364,
0.3473638892173767,
-0.02157120406627655,
0.0206294022500515
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. include developmental delay, developmental regression, intellectual disability, seizures, hypotonia, spasticity, and movement disorders . Developmental delays and neurologic dysfunction can be seen even in individuals without documented episodes of hyperammonemia or ketoacidosis . The prevalence of intellectual disability can vary between approximately 35% and 76% depending on the reported cohort .Seizures were reported in 13%-53% and EEG abnormalities in 40%-63% of Individuals with PA. Reported forms of seizures included infantile spasms, tonic-clonic, tonic, myoclonic, atonic, absence, and focal . Seizures were one of the presenting features of the initial metabolic episode in 12%-26% of cases .Basal ganglia changes. Individuals with PA are predisposed to basal ganglia lesions, especially during episodes of acute encephalopathy or metabolic instability . Basal ganglia changes seen in 7%-56% of individuals may be preceded by an acute “stroke-like” episode and manifest as altered mental status, dystonia, choreoa | [
-0.04304801672697067,
0.05069717764854431,
-0.1491314321756363,
-0.04953916370868683,
0.05871474742889404,
-0.13108475506305695,
-0.007975403219461441,
-0.15374656021595,
-0.07985176891088486,
0.009976780042052269,
0.09978124499320984,
-0.08794751763343811,
0.011452368460595608,
0.09378376603126526,
-0.3331173360347748,
0.0667218565940857,
0.10541148483753204,
-0.056626155972480774,
-0.18834969401359558,
-0.2354317009449005,
-0.07838902622461319,
-0.1248355582356453,
0.10310834646224976,
0.12849918007850647,
0.1973877251148224,
-0.26867741346359253,
0.20277582108974457,
-0.24718524515628815,
0.22213417291641235,
0.09929624199867249,
-0.1517328917980194,
0.06155400350689888,
0.26708248257637024,
-0.3530363440513611,
-0.15385128557682037,
-0.2853300869464874,
-0.10861116647720337,
-0.11482096463441849,
0.1528346836566925,
-0.21460247039794922,
0.06169934198260307,
-0.056775398552417755,
0.14926265180110931,
-0.10094033181667328,
0.235076904296875,
-0.019282624125480652,
-0.1056026890873909,
-0.12250971794128418,
-0.24723570048809052,
0.2906590402126312,
0.08803097903728485,
0.0511011928319931,
-0.3000606596469879,
0.08507213741540909,
0.026118092238903046,
-0.16571956872940063,
-0.08331966400146484,
0.08310553431510925,
-0.3154037892818451,
0.27727270126342773,
0.19646795094013214,
-0.1342886984348297,
-0.15763729810714722,
-0.2966267466545105,
0.18067379295825958,
-0.09796803444623947,
-0.12249447405338287,
0.14790289103984833,
0.18196360766887665,
-0.1822669804096222,
0.10706960409879684,
-0.12154237926006317,
-0.15176382660865784,
0.2240724414587021,
-0.11519768089056015,
0.05906125530600548,
0.03490164130926132,
0.10608964413404465,
-0.15216495096683502,
-0.2505544126033783,
-0.32749873399734497,
-0.030063003301620483,
0.010500972159206867,
-0.19843409955501556,
-0.17262449860572815,
-0.08787572383880615,
0.13895194232463837,
-0.025305500254034996,
-0.03345121443271637,
0.15800851583480835,
0.17590340971946716,
0.18588078022003174,
-0.16974903643131256,
0.05229893699288368,
-0.0023957183584570885,
0.11646345257759094,
0.19510504603385925,
0.0046696714125573635,
-0.24560897052288055,
0.056226469576358795,
-0.024354558438062668,
0.1110912561416626,
-0.10638899356126785,
0.10054463148117065,
0.04186922684311867,
0.05003362149000168,
-0.07311566919088364,
0.026472117751836777,
-0.06090748310089111,
0.03632928803563118,
0.019518302753567696,
-0.15804477035999298,
0.22250434756278992,
-0.10507582128047943,
-0.5764936208724976,
-0.04477890208363533,
-0.22260844707489014,
0.4695546627044678,
0.11232595890760422,
0.09578031301498413,
0.05299268290400505,
0.024641571566462517,
0.004878398962318897,
0.12655392289161682,
0.06399736553430557,
-0.012781688943505287,
0.17515145242214203,
0.06848829984664917,
0.1435781866312027,
0.05788515880703926,
0.17139281332492828,
-0.06148795410990715,
-0.00785610917955637,
-0.14838820695877075,
0.011491590179502964,
-0.05864202603697777,
-0.3995184302330017,
-0.29163050651550293,
-0.17419518530368805,
0.035138361155986786,
0.11867088824510574,
-0.02092624269425869,
0.16775374114513397,
0.19995686411857605,
0.23293396830558777,
0.15000562369823456,
0.2677946090698242,
0.022750159725546837,
0.1288391798734665,
-0.031077474355697632,
-0.1195661872625351,
-0.12364558130502701,
0.20172403752803802,
0.04625843092799187,
-0.07889910787343979,
0.2225014716386795,
0.04025450348854065,
0.3137280344963074,
-0.028726505115628242,
0.0705033540725708,
-0.177977055311203,
-0.14200451970100403,
-0.1740838587284088,
0.008506076410412788,
-0.22394172847270966,
0.019565125927329063,
-0.35784199833869934,
-0.10464082658290863,
0.019443778321146965,
-0.16010430455207825,
-0.09540440142154694,
0.0034593672025948763,
-0.0008385683177039027,
0.195260688662529,
0.00855650007724762,
-0.0899915024638176,
-0.020010802894830704,
0.24110594391822815,
-0.21844719350337982,
0.2719920873641968,
0.1774016171693802,
-0.19588038325309753,
-0.42052099108695984,
0.06310379505157471,
-0.06320563703775406,
-0.09692446887493134,
0.18668754398822784,
0.21083857119083405,
-0.14136946201324463,
0.09432408213615417,
0.22548814117908478,
0.1380373239517212,
0.06554044783115387,
0.21695363521575928,
-0.1324426829814911,
-0.2327108234167099,
0.04490736871957779,
-0.001666729454882443,
-0.03236287459731102,
0.01274840161204338,
-0.19848957657814026,
-0.12466155737638474,
0.15895889699459076,
0.027210835367441177,
-0.14509369432926178,
-0.07110368460416794,
-0.034310124814510345,
-0.04222860932350159,
-0.030485402792692184,
0.23879146575927734,
-0.22301135957241058,
0.3575480580329895,
-0.23508019745349884,
-0.19360941648483276,
-0.06677806377410889,
-0.015188096091151237,
-0.0516524575650692,
0.045748040080070496,
-0.058713965117931366,
0.1805003434419632,
0.10004376620054245,
0.030296800658106804,
0.005478471051901579,
-0.14776118099689484,
-0.09846293181180954,
-0.013497630134224892,
-0.347779780626297,
-0.21417534351348877,
0.2016562521457672,
-0.12786971032619476,
-0.35563912987709045,
0.18036136031150818,
-0.11054074764251709,
0.11618455499410629,
0.02446708269417286,
-0.31386709213256836,
-0.1294148564338684,
0.2911938428878784,
-0.12111560255289078,
-0.10487662255764008,
-0.39094871282577515,
-0.031340647488832474,
0.04594440385699272,
-0.10888322442770004,
-0.11130638420581818,
0.14735457301139832,
0.08519846946001053,
0.07412929832935333,
-0.07343079894781113,
0.2834736108779907,
-0.13735096156597137,
0.1371944099664688,
0.03709428757429123,
0.10442925244569778,
-0.3644041121006012,
-0.21920132637023926,
0.12216904759407043,
-0.02570018731057644,
0.09072627127170563,
0.016850681975483894,
-0.11140934377908707,
0.2782926559448242,
-0.06907566636800766,
0.009341899305582047,
0.005233530420809984,
0.030232105404138565,
-0.14379072189331055,
0.058015305548906326,
-0.06252801418304443,
-0.2996894419193268,
-0.08660584688186646,
0.18594127893447876,
0.1662752777338028,
-0.012546190991997719,
-0.2567921280860901,
-0.08558014035224915,
0.28213560581207275,
0.06882070749998093,
0.12192784249782562,
0.016484374180436134,
-0.14540475606918335,
0.1271655112504959,
0.06069985777139664,
0.02556600235402584,
0.26719895005226135,
0.020868927240371704,
-0.010827906429767609,
-0.04742048680782318,
-0.08640342950820923,
0.12186603993177414,
0.030068527907133102,
0.34713879227638245,
-0.05618860945105553,
0.005555039271712303,
0.17689189314842224,
0.3003547787666321,
-0.026214592158794403,
0.030345141887664795,
-0.0968901738524437,
0.08017664402723312,
-0.05358309671282768,
0.059683285653591156,
0.25334638357162476,
0.10319319367408752,
-0.38763627409935,
-0.04122888296842575,
0.012524601072072983,
-0.17569060623645782,
0.024831166490912437,
0.2566656470298767,
-0.19117878377437592,
-0.24796214699745178,
-0.027241388335824013,
-0.03948497027158737,
-0.08306831866502762,
0.013764136470854282,
0.15844440460205078,
0.16635382175445557,
0.1475921869277954,
0.2379864752292633,
-0.169654980301857,
0.11918922513723373,
0.1626807451248169,
0.1452966034412384,
-0.15058623254299164,
-0.0161148551851511,
-0.06743188947439194,
0.11768236011266708,
-0.042483627796173096,
0.13967032730579376,
-0.20481650531291962,
0.22075122594833374,
0.04901666194200516,
-0.26106929779052734,
0.10902586579322815,
-0.15030553936958313,
0.44577085971832275,
0.11285029351711273,
-0.13136669993400574,
0.09407946467399597,
0.205118790268898,
-0.48269620537757874,
-0.07258646190166473,
-0.3480006158351898,
-0.20501424372196198,
0.12218644469976425,
-0.15210524201393127,
0.27510321140289307,
0.07475084811449051,
0.04996233060956001,
-0.15217292308807373,
0.09457005560398102,
-0.1699051409959793,
-0.09196607768535614,
0.10747694224119186,
-0.02674577571451664,
-0.12806451320648193,
0.08301433175802231,
0.1439296007156372,
0.08857300877571106,
-0.28890496492385864,
0.08033937960863113,
0.20250776410102844,
-0.192940354347229,
0.11016011238098145,
-0.3369462192058563,
-0.1270759403705597,
0.07157353311777115,
0.2471632957458496,
-0.09371424466371536,
0.013574223965406418,
0.08474733680486679,
-0.022467253729701042,
0.1381620466709137,
-0.2200886756181717,
0.11133665591478348,
-0.15567763149738312,
-0.07655346393585205,
-0.43954238295555115,
-0.18935057520866394,
0.21333737671375275,
0.018119607120752335,
0.08383998274803162,
0.02803691290318966,
-0.12851087749004364,
0.06900805979967117,
-0.18841342628002167,
0.39829519391059875,
0.34449443221092224,
-0.6012557744979858,
0.16061776876449585,
0.23182791471481323,
-0.13525812327861786,
0.1759868860244751,
0.09031759202480316,
0.05448123812675476,
0.11114981770515442,
0.18889349699020386,
-0.11008089780807495,
-0.016324205324053764,
0.08182087540626526,
0.005824693012982607,
0.2520107626914978,
0.05194031819701195,
0.22556550800800323,
0.25468114018440247,
0.2598426640033722,
0.1250091940164566,
-0.17675843834877014,
0.11105165630578995,
0.0039551169611513615,
-0.26816946268081665,
0.00045850241440348327,
-0.011238240636885166,
-0.16385826468467712,
-0.15453483164310455,
-0.05882181227207184,
0.09452874213457108,
0.1432153880596161,
-0.07072688639163971,
-0.18551591038703918,
-0.10077373683452606,
-0.06790680438280106,
0.14830467104911804,
-0.16606178879737854,
0.25254547595977783,
0.032506365329027176,
-0.08056146651506424,
0.022748081013560295,
-0.02677236683666706,
0.2699812352657318,
0.06960836797952652,
-0.11427154392004013,
0.1277325600385666,
0.1843651980161667,
0.2725493013858795,
-0.17708994448184967,
0.02555299736559391,
-0.16511204838752747,
-0.05009777843952179,
0.05185570567846298,
0.008716180920600891,
-0.008344830013811588,
-0.12192782014608383,
-0.06671318411827087,
0.26750269532203674,
0.2913353443145752,
0.10838046669960022,
-0.11745604872703552,
-0.04725152626633644,
0.04361805319786072,
-0.05837840586900711,
-0.04945547133684158,
0.12128878384828568,
0.08486802130937576,
0.05472452938556671,
0.21961933374404907,
0.01896488294005394,
0.0005756404134444892,
-0.020018236711621284,
-0.12497372925281525,
0.14374683797359467,
0.2551132142543793,
-0.14365339279174805,
-0.14957818388938904,
0.21073627471923828,
-0.1307465136051178,
0.11759176105260849,
0.1246238425374031,
0.1641344428062439,
0.04743976891040802,
0.14403001964092255,
-0.09407848864793777,
0.19108353555202484,
-0.19622313976287842,
-0.14360633492469788,
-0.1677774041891098,
-0.018460091203451157,
-0.01350332796573639,
0.05117422342300415,
-0.01828456111252308,
-0.05151025578379631,
0.09812121838331223,
0.16615331172943115,
-0.2536066174507141,
0.2916335463523865,
-0.23738573491573334,
0.15329700708389282,
0.5188047289848328,
0.038773659616708755,
0.02460758201777935,
-0.06598030030727386,
0.020827608183026314,
0.4154643714427948,
-0.03027532622218132,
-0.323092520236969,
0.050358567386865616,
-0.08951561897993088,
0.13634967803955078,
0.0475618802011013,
-0.10048949718475342,
-0.016825111582875252,
-0.1987103670835495,
-0.0753752663731575,
-0.059207573533058167,
-0.01882988028228283,
-0.015460558235645294,
-0.1939712017774582,
-0.06968368589878082,
0.18001870810985565,
0.012865835800766945,
0.1363523006439209,
0.016789929941296577,
-0.061139337718486786,
0.1299588531255722,
-0.2595868706703186,
0.19975845515727997,
0.3451327979564667,
0.15428537130355835,
-0.31306612491607666,
0.15485508739948273,
0.03688662499189377,
0.24409516155719757,
-0.03793393075466156,
0.2640922963619232,
-0.16242511570453644,
0.18290407955646515,
0.11497069895267487,
-0.10247253626585007,
-0.17516019940376282,
-0.02908826433122158,
-0.01897989772260189,
-0.16603519022464752,
0.0364672988653183,
0.16206881403923035,
-0.13782095909118652,
0.03302134573459625,
-0.25600817799568176,
0.07879814505577087,
-0.19186177849769592,
-0.2516356110572815,
0.09045571833848953,
-0.08849099278450012,
0.048263270407915115,
-0.12649154663085938,
0.16790634393692017,
0.3118179440498352,
0.20399944484233856,
0.2939748167991638,
0.006254891864955425,
-0.034232739359140396,
-0.21575306355953217,
-0.037887077778577805,
0.05664476752281189,
-0.06984882801771164,
0.03432964161038399,
-0.1388261616230011,
-0.17470891773700714,
-0.2370859682559967,
0.052900828421115875,
-0.04461090266704559,
0.0010358187137171626,
-0.19388364255428314,
0.2373073250055313,
-0.10601109266281128,
0.112751804292202,
0.042130157351493835,
-0.1390659511089325,
0.07298806309700012,
0.043846774846315384,
0.11753629148006439,
0.05836586654186249,
0.12745912373065948,
0.01687367632985115,
-0.11610922962427139,
0.04724615812301636,
-0.13632901012897491,
-0.4175010025501251,
-0.12826469540596008,
0.14138834178447723,
0.06715406477451324,
-0.16194672882556915,
0.1697661280632019,
-0.351515531539917,
0.09826526790857315,
0.01705298200249672,
0.07739544659852982,
0.026739973574876785,
0.39614787697792053,
-0.013640216551721096,
-0.018478013575077057,
-0.16373328864574432,
0.05508364737033844,
0.07537580281496048,
0.2375735342502594,
-0.20896045863628387,
0.18947015702724457,
-0.2543575167655945,
0.12116347253322601,
0.24587178230285645,
0.31252044439315796,
0.18892553448677063,
0.02722213789820671,
-0.07080090790987015,
-0.13233116269111633,
-0.0776953399181366,
0.1915304809808731,
-0.46348947286605835,
-0.16247886419296265,
0.03132237121462822,
0.2160291075706482,
0.21582067012786865,
0.08528092503547668,
-0.12674716114997864,
0.08182433247566223,
-0.1258874386548996,
0.19710151851177216,
0.021223798394203186,
0.054087359458208084,
0.055337052792310715,
0.35056009888648987,
-0.0433543436229229,
0.10262410342693329,
-0.11374920606613159,
-0.09564043581485748,
0.05148778855800629,
0.0006198824266903102,
-0.06593380123376846,
0.11374656111001968,
0.009985506534576416,
0.08064733445644379,
0.285230427980423,
0.11657975614070892,
0.05143047496676445,
-0.06916891783475876,
0.08547071367502213,
0.12963373959064484,
0.25185462832450867,
-0.16906121373176575,
0.21528656780719757,
-0.42377969622612,
-0.03265146166086197,
-0.2181994915008545,
0.10794176161289215,
-0.2735748291015625,
0.10463141649961472,
-0.11865752190351486,
-0.3165656328201294,
-0.05528184399008751,
-0.31326135993003845,
0.12445726990699768,
-0.1311534345149994,
-0.156826913356781,
0.18746967613697052,
0.1671036332845688,
-0.16386426985263824,
-0.1343819499015808,
-0.08315766602754593,
0.05830471217632294,
-0.04296443611383438,
0.0695248395204544,
0.0019047323148697615,
0.043972693383693695,
-0.12932199239730835,
-0.25145357847213745,
0.10938480496406555,
0.05356287956237793,
-0.14480902254581451,
0.13445428013801575,
-0.21227099001407623,
-0.3271273076534271,
-0.036468587815761566,
-0.10309857130050659,
-0.05839100107550621,
-0.014991377480328083,
-0.02131369709968567,
0.04564083740115166,
0.1609673649072647,
-0.1485450118780136,
0.4002021849155426,
0.053497329354286194,
-0.3613010048866272,
-0.04010876268148422,
0.052178528159856796,
0.1796775758266449,
0.150945782661438,
0.06985099613666534,
-0.05263439938426018,
0.32367920875549316,
-0.29691097140312195,
0.194121316075325,
-0.08781623095273972,
0.2518851161003113,
0.12895889580249786,
-0.15958918631076813,
-0.11174443364143372,
0.3793583810329437,
-0.20818030834197998,
-0.30495867133140564,
-0.05536535754799843,
-0.2845723628997803,
0.010516121983528137,
0.10052386671304703,
0.16396856307983398,
-0.01616639271378517,
-0.08201117813587189,
0.11937006562948227,
-0.03494695574045181,
0.023901155218482018,
-0.2450481504201889,
-0.023165075108408928,
-0.1638079136610031,
-0.018798695877194405,
0.1890556812286377,
-0.19315752387046814,
0.009909890592098236,
-0.014957088977098465,
0.08765166997909546,
-0.18169814348220825,
-0.3295995891094208,
0.08126027882099152,
-0.03713307902216911,
0.12302976846694946,
0.06852938234806061,
-0.15063081681728363,
-0.010100235231220722,
-0.09826654940843582,
0.21516607701778412,
0.08915704488754272,
-0.01964029297232628,
-0.26596134901046753,
-0.13434085249900818,
-0.3269268572330475,
0.17753539979457855,
-0.1463383287191391,
-0.07808348536491394,
-0.056798409670591354,
-0.09320389479398727,
-0.17565971612930298,
-0.1891685575246811,
-0.22293131053447723,
0.25264742970466614,
0.07989376038312912,
0.056120943278074265,
-0.057178739458322525,
0.1793164312839508,
0.0380944088101387,
-0.04278852790594101,
-0.06658336520195007,
-0.04940696060657501,
0.08376766741275787,
0.03488386422395706,
0.01598271168768406,
0.002125996630638838,
0.1267997771501541,
-0.062450747936964035,
-0.10954700410366058,
-0.1760837733745575,
-0.00859910249710083,
-0.08779390156269073,
-0.10253968834877014,
0.015461336821317673,
-0.11829273402690887,
0.28524595499038696,
-0.15424780547618866,
0.2981729209423065,
-0.0054107182659208775,
-0.026426151394844055
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , tonic-clonic, tonic, myoclonic, atonic, absence, and focal . Seizures were one of the presenting features of the initial metabolic episode in 12%-26% of cases .Basal ganglia changes. Individuals with PA are predisposed to basal ganglia lesions, especially during episodes of acute encephalopathy or metabolic instability . Basal ganglia changes seen in 7%-56% of individuals may be preceded by an acute “stroke-like” episode and manifest as altered mental status, dystonia, choreoathetosis, or hemiplegia . The frequency of movement disorders in PA appears to be independent of the age of symptom onset .Psychiatric manifestations. The prevalence of other comorbidities such as attention deficit disorder, autism spectrum disorder, anxiety, and acute psychosis is incompletely characterized . Acute psychosis can be a presenting feature of PA in older individuals, especially in those not evaluated by newborn screen, thus warranting a high index of suspicion for this uncommon cause of psychosis in the general population . | [
-0.018406763672828674,
0.2150263488292694,
-0.08974840492010117,
0.03074803575873375,
0.12214551120996475,
-0.0580991692841053,
-0.05799474939703941,
-0.20560942590236664,
-0.12196353077888489,
-0.049716733396053314,
0.23754094541072845,
-0.15117096900939941,
0.1310751736164093,
0.022877225652337074,
-0.26222744584083557,
0.09924682974815369,
0.09468519687652588,
-0.05785679072141647,
-0.20001234114170074,
-0.2944584786891937,
-0.013444199226796627,
-0.026447929441928864,
0.16031070053577423,
0.1474423110485077,
0.19412563741207123,
-0.3817327916622162,
0.1059359610080719,
-0.2927022874355316,
0.1217612698674202,
0.10048194229602814,
-0.23477216064929962,
0.05097656324505806,
0.2608533203601837,
-0.20185799896717072,
-0.19234468042850494,
-0.32669058442115784,
-0.14363627135753632,
-0.08363106846809387,
0.2377106100320816,
-0.15144670009613037,
-0.006007717456668615,
0.019702155143022537,
0.15013566613197327,
-0.10658880323171616,
0.2665535509586334,
-0.0419425368309021,
-0.033287063241004944,
-0.17153914272785187,
-0.2444492131471634,
0.4352501928806305,
0.013417387381196022,
0.04510630667209625,
-0.23354755342006683,
0.06492994725704193,
0.14448046684265137,
-0.08464907854795456,
-0.13965550065040588,
0.03718859329819679,
-0.38340672850608826,
0.29205217957496643,
0.22619885206222534,
-0.15189209580421448,
-0.1230667382478714,
-0.2876836359500885,
0.16533708572387695,
-0.03157799318432808,
-0.1224861666560173,
0.12499906122684479,
0.2116941213607788,
-0.11307044327259064,
0.08612361550331116,
-0.19764655828475952,
-0.10683371126651764,
0.15134315192699432,
-0.13677674531936646,
0.07097098231315613,
0.02198914624750614,
0.06178934499621391,
-0.08588142693042755,
-0.35584571957588196,
-0.3771592974662781,
-0.10509859025478363,
0.08668401837348938,
-0.10790508985519409,
-0.229067862033844,
-0.10859058052301407,
0.1938241720199585,
0.07628583163022995,
0.011762642301619053,
0.1540766954421997,
0.22038286924362183,
0.369096577167511,
-0.18000218272209167,
0.09395091980695724,
-0.03894466161727905,
0.11418840289115906,
0.145564466714859,
0.030157357454299927,
-0.1578417271375656,
0.10680607706308365,
0.05211234465241432,
0.10308969765901566,
-0.14362524449825287,
0.019410468637943268,
0.22442182898521423,
-0.043360188603401184,
-0.051696889102458954,
0.1237502470612526,
-0.13891112804412842,
0.0032877782359719276,
-0.05777883902192116,
-0.04992211237549782,
0.22036422789096832,
-0.10938291996717453,
-0.47147491574287415,
-0.1499141901731491,
-0.09111396223306656,
0.40063583850860596,
0.18108434975147247,
0.14543980360031128,
-0.04755149409174919,
0.06532184779644012,
-0.07704884558916092,
0.13746246695518494,
0.050017550587654114,
-0.10190840810537338,
0.06547059863805771,
0.10545892268419266,
0.20272865891456604,
0.02466634474694729,
0.16969937086105347,
0.04543597251176834,
0.00212199822999537,
-0.09897895157337189,
-0.14245131611824036,
-0.14257946610450745,
-0.38809624314308167,
-0.24655471742153168,
-0.154820054769516,
0.081718809902668,
0.16144882142543793,
0.026448216289281845,
0.04750287905335426,
0.211317777633667,
0.012257940135896206,
0.24301384389400482,
0.19572624564170837,
-0.018969235941767693,
0.12220517545938492,
0.10004235059022903,
-0.06108495965600014,
-0.04113146662712097,
0.2854839563369751,
0.1111990362405777,
-0.025901449844241142,
0.2273508608341217,
0.10056691616773605,
0.27525094151496887,
-0.08959784358739853,
0.1248762458562851,
-0.14722007513046265,
-0.20788165926933289,
-0.125688374042511,
0.028062470257282257,
-0.1552673578262329,
0.08073248714208603,
-0.24638758599758148,
-0.11215481162071228,
0.047933608293533325,
-0.1307421177625656,
-0.09489365667104721,
-0.017468048259615898,
0.037378616631031036,
0.20546633005142212,
-0.0660388246178627,
-0.07369916141033173,
-0.009901853278279305,
0.24239905178546906,
-0.22816704213619232,
0.15929445624351501,
0.19236783683300018,
-0.18183785676956177,
-0.3955555260181427,
0.1140097826719284,
0.0054985531605780125,
-0.11227322369813919,
0.18288813531398773,
0.12120036780834198,
-0.20796853303909302,
0.17688825726509094,
0.20561844110488892,
0.11849208921194077,
-0.02120942994952202,
0.18460923433303833,
-0.1746428906917572,
-0.1694018542766571,
0.050487808883190155,
0.03959609940648079,
-0.05475221574306488,
-0.0788409560918808,
-0.22378981113433838,
-0.18131455779075623,
-0.002400429453700781,
0.0873575434088707,
-0.1137862578034401,
-0.02022765763103962,
-0.06307157129049301,
-0.052685514092445374,
0.07230180501937866,
0.10625815391540527,
-0.17781773209571838,
0.2830160856246948,
-0.21122542023658752,
-0.12809249758720398,
-0.07856329530477524,
0.0449712872505188,
-0.0010971017181873322,
0.03624355420470238,
-0.14529424905776978,
0.25824517011642456,
-0.007473251316696405,
0.05725907161831856,
-0.13803905248641968,
-0.14210465550422668,
-0.11867468059062958,
0.03534574434161186,
-0.24107018113136292,
-0.18804623186588287,
0.22121600806713104,
-0.14740291237831116,
-0.36495891213417053,
0.25518766045570374,
-0.0700172707438469,
0.03289807587862015,
-0.08690745383501053,
-0.19685401022434235,
-0.1300450563430786,
0.2874510586261749,
-0.08370745927095413,
-0.16107359528541565,
-0.366283118724823,
0.011476520448923111,
0.036528900265693665,
-0.09871090948581696,
-0.04827401787042618,
0.1470784991979599,
0.13336816430091858,
0.13257402181625366,
-0.17963643372058868,
0.29227331280708313,
-0.10228854417800903,
0.17913216352462769,
-0.033196404576301575,
0.13522878289222717,
-0.3181171715259552,
-0.21052992343902588,
0.0629294216632843,
-0.07298340648412704,
0.11518459767103195,
0.023614488542079926,
-0.10164591670036316,
0.18317541480064392,
-0.15790972113609314,
-0.042065948247909546,
0.039173685014247894,
0.0602509044110775,
-0.22701747715473175,
-0.008355856873095036,
-0.07277657836675644,
-0.22135597467422485,
-0.1257280707359314,
0.3806787431240082,
0.12899361550807953,
-0.03339846804738045,
-0.3755670189857483,
0.0015522566391155124,
0.2967635691165924,
0.10604928433895111,
0.13783729076385498,
0.020296713337302208,
-0.16027577221393585,
0.07289436459541321,
0.13991782069206238,
-0.05869497358798981,
0.2434435933828354,
-0.017294082790613174,
-0.033406179398298264,
-0.10428494215011597,
-0.05709855630993843,
0.13516412675380707,
0.05174706503748894,
0.3374127745628357,
-0.14621081948280334,
-0.06677764654159546,
0.1050676703453064,
0.21319358050823212,
-0.07143810391426086,
0.11316872388124466,
-0.1477886587381363,
0.08990270644426346,
-0.030522916465997696,
0.011982638388872147,
0.21096381545066833,
0.023527413606643677,
-0.3945903480052948,
-0.020025085657835007,
0.030302302911877632,
-0.1770225465297699,
0.010826303623616695,
0.1893293857574463,
-0.19169428944587708,
-0.23109881579875946,
-0.027509581297636032,
-0.06889624893665314,
-0.035795800387859344,
-0.006474162917584181,
-0.0070274826139211655,
0.09266822785139084,
0.16687986254692078,
0.2783221900463104,
-0.2058883160352707,
0.07056354731321335,
0.1706632673740387,
0.13001000881195068,
-0.025041360408067703,
-0.0020505795255303383,
-0.015287731774151325,
0.15446345508098602,
-0.12324171513319016,
0.16686108708381653,
-0.16729435324668884,
0.11381135135889053,
0.023494500666856766,
-0.2325468808412552,
0.0891876220703125,
-0.14290161430835724,
0.3638693392276764,
0.11975402384996414,
-0.1796623319387436,
0.089819997549057,
0.18951456248760223,
-0.34156545996665955,
-0.13587692379951477,
-0.24256442487239838,
-0.14142082631587982,
0.10538773983716965,
0.0012854294618591666,
0.08685298264026642,
0.02563716471195221,
0.009275357238948345,
-0.25755777955055237,
0.0445307232439518,
-0.0999942496418953,
-0.05799451842904091,
0.08141760528087616,
0.0419175811111927,
-0.16159981489181519,
0.11461149901151657,
0.13420356810092926,
0.05057523399591446,
-0.24889619648456573,
0.10440424829721451,
0.23815584182739258,
-0.15170535445213318,
0.1146421879529953,
-0.3965991735458374,
-0.1706920713186264,
0.11103968322277069,
0.32750770449638367,
-0.01944439299404621,
0.08135099709033966,
0.1273055523633957,
0.011738112196326256,
0.10275325924158096,
-0.22017598152160645,
0.023660562932491302,
-0.1297648549079895,
-0.13669432699680328,
-0.49880343675613403,
-0.06724552810192108,
0.2595832049846649,
0.043837882578372955,
0.21036484837532043,
0.0630054846405983,
-0.14622922241687775,
0.006395009346306324,
-0.2619219720363617,
0.32761284708976746,
0.2735065221786499,
-0.5392550230026245,
0.08395542949438095,
0.1827375292778015,
-0.17831917107105255,
0.10192035138607025,
0.14034809172153473,
0.08155278861522675,
0.06684549152851105,
0.2377631962299347,
-0.0895073413848877,
-0.022438732907176018,
0.040444377809762955,
-0.09311269968748093,
0.21405458450317383,
0.05467710644006729,
0.1149730533361435,
0.1768510490655899,
0.28116723895072937,
0.176127627491951,
-0.13191989064216614,
0.12465448677539825,
0.0007939368369989097,
-0.2843136489391327,
-0.03297631815075874,
-0.011121975257992744,
-0.11687581241130829,
-0.22943079471588135,
-0.014187239110469818,
0.02295413799583912,
0.12415578216314316,
-0.07069473713636398,
-0.22732850909233093,
-0.05239558219909668,
-0.13471423089504242,
0.10358733683824539,
-0.11619922518730164,
0.1894327849149704,
-0.009156246669590473,
-0.06603852659463882,
0.015048337168991566,
0.01920093037188053,
0.30849865078926086,
0.033940836787223816,
-0.08954522013664246,
0.17468178272247314,
0.19747576117515564,
0.24437645077705383,
-0.14988505840301514,
-0.00877829547971487,
-0.10316910594701767,
-0.0775916799902916,
0.039170924574136734,
0.018157312646508217,
-0.015045042149722576,
-0.21241258084774017,
-0.006842122413218021,
0.18591739237308502,
0.3000076711177826,
0.15818342566490173,
-0.1741703450679779,
-0.1312357783317566,
0.020086346194148064,
0.09465094655752182,
-0.09668152034282684,
0.10825350880622864,
0.023770354688167572,
0.045632220804691315,
0.27504396438598633,
0.06646247953176498,
-0.05155415087938309,
-0.07703890651464462,
-0.04089519754052162,
0.08812682330608368,
0.23186224699020386,
-0.012569883838295937,
-0.095706045627594,
0.1498907059431076,
-0.146673321723938,
0.032780349254608154,
0.12876376509666443,
0.15336240828037262,
0.025782693177461624,
0.1192079409956932,
-0.0540214367210865,
0.2861550748348236,
-0.1988438367843628,
-0.1396317332983017,
-0.22899003326892853,
-0.05859073996543884,
-0.05181460455060005,
-0.020292801782488823,
0.08832462877035141,
-0.1394561231136322,
-0.013018907979130745,
0.14986589550971985,
-0.16702575981616974,
0.24496756494045258,
-0.1990858018398285,
0.22579829394817352,
0.596760094165802,
0.14352186024188995,
0.092058926820755,
-0.021125826984643936,
0.019681621342897415,
0.36068621277809143,
0.03528982773423195,
-0.34295257925987244,
0.013197262771427631,
-0.15283498167991638,
0.08640493452548981,
0.011197920888662338,
-0.04750213772058487,
0.06436937302350998,
-0.2118789255619049,
-0.06233156472444534,
-0.1569666564464569,
-0.07016584277153015,
0.047825176268815994,
-0.15461225807666779,
-0.028011465445160866,
0.05955590680241585,
-0.06491206586360931,
0.10740874707698822,
-0.0014059569220989943,
-0.05243227630853653,
0.14381733536720276,
-0.26724421977996826,
0.15510861575603485,
0.2478334903717041,
0.17293541133403778,
-0.1526661068201065,
0.1525915414094925,
0.051985885947942734,
0.1894841492176056,
-0.08996006101369858,
0.19445636868476868,
-0.1427667737007141,
0.19146186113357544,
0.13398757576942444,
-0.10940589755773544,
-0.057778868824243546,
-0.06534728407859802,
-0.06824889779090881,
-0.10007701814174652,
-0.08649305999279022,
0.16665039956569672,
-0.06841275840997696,
0.05176227167248726,
-0.19066569209098816,
0.0708649680018425,
-0.13240033388137817,
-0.29168257117271423,
0.10267859697341919,
-0.048793502151966095,
0.17362681031227112,
0.030582470819354057,
0.11265531182289124,
0.21856428682804108,
0.2926110327243805,
0.3252967298030853,
0.10379473865032196,
-0.004741352517157793,
-0.24543356895446777,
-0.06004464998841286,
0.08911852538585663,
-0.04031305015087128,
0.019020047038793564,
-0.046525806188583374,
-0.07841942459344864,
-0.24583785235881805,
0.016424477100372314,
-0.0661504864692688,
-0.09085065871477127,
-0.19334794580936432,
0.3299734890460968,
-0.08789541572332382,
0.08635037392377853,
-0.015779906883835793,
-0.3035867214202881,
0.08802246302366257,
0.10866354405879974,
0.08189095556735992,
0.08684034645557404,
0.0936666950583458,
0.05052556097507477,
-0.09575367718935013,
0.09921245276927948,
-0.22311128675937653,
-0.34247899055480957,
-0.14515821635723114,
0.07806217670440674,
0.032771337777376175,
-0.2503642439842224,
0.1896928995847702,
-0.2240784913301468,
0.18391945958137512,
0.054028064012527466,
0.13669094443321228,
0.028335269540548325,
0.41876959800720215,
0.027695970609784126,
-0.039718687534332275,
-0.16229024529457092,
0.020136166363954544,
0.16041548550128937,
0.2558676600456238,
-0.12746712565422058,
0.1482417732477188,
-0.1867997646331787,
0.07219041138887405,
0.19586476683616638,
0.23114490509033203,
0.1688385009765625,
-0.07302313297986984,
-0.2001533806324005,
-0.19739273190498352,
-0.17513121664524078,
0.17969352006912231,
-0.5957835912704468,
-0.11715653538703918,
0.04355483874678612,
0.2946038544178009,
0.15298496186733246,
0.12353544682264328,
-0.14669324457645416,
0.11312554776668549,
-0.007313312031328678,
0.14145734906196594,
0.07368458062410355,
-0.011723288334906101,
0.1147741749882698,
0.40884342789649963,
-0.1575041115283966,
0.19167223572731018,
-0.037946268916130066,
-0.016477126628160477,
0.05511898919939995,
-0.02302456833422184,
0.0243174247443676,
0.14272302389144897,
0.009517981670796871,
0.040117330849170685,
0.2812998592853546,
0.1204342395067215,
0.05422753095626831,
0.031286537647247314,
0.02074761874973774,
-0.03235623985528946,
0.16442665457725525,
-0.18872323632240295,
0.1460324078798294,
-0.3304227292537689,
0.029776697978377342,
-0.2397649735212326,
0.03529470041394234,
-0.22149193286895752,
0.08688753098249435,
-0.034608155488967896,
-0.3571809232234955,
-0.04294080287218094,
-0.303507924079895,
0.10605575889348984,
-0.03914882615208626,
-0.2276831716299057,
0.1641453057527542,
0.12416411191225052,
-0.10245160013437271,
-0.1590528041124344,
-0.0998392328619957,
0.07191263139247894,
-0.030101116746664047,
0.07028387486934662,
-0.08118730783462524,
0.07291427254676819,
-0.13322973251342773,
-0.15177282691001892,
0.14911261200904846,
0.09352488070726395,
-0.0565171092748642,
0.12889868021011353,
-0.2202521562576294,
-0.20778784155845642,
-0.14472463726997375,
-0.07563456892967224,
-0.12016960978507996,
0.006256817374378443,
-0.057443294674158096,
0.11640696972608566,
0.18242010474205017,
-0.060533829033374786,
0.38236385583877563,
0.06867248564958572,
-0.3794398605823517,
-0.07078393548727036,
0.051483288407325745,
0.1483013778924942,
0.12448695302009583,
0.10422147065401077,
0.055466633290052414,
0.37471243739128113,
-0.2619653344154358,
0.1762532740831375,
-0.06646208465099335,
0.19076895713806152,
0.08978262543678284,
-0.16473007202148438,
-0.09489314258098602,
0.22087383270263672,
-0.1659119725227356,
-0.2575681805610657,
-0.07833307981491089,
-0.21719932556152344,
-0.07168322056531906,
0.08218739181756973,
0.1733628511428833,
0.16532768309116364,
-0.09107327461242676,
0.1308358758687973,
-0.04261988773941994,
0.044163018465042114,
-0.30723950266838074,
-0.11760896444320679,
-0.10974252223968506,
-0.020435841754078865,
0.19086991250514984,
-0.18464118242263794,
-0.03383341059088707,
0.11685523390769958,
0.009421009570360184,
-0.14204159379005432,
-0.32568249106407166,
0.08950719237327576,
-0.0695023313164711,
0.07466579228639603,
0.05323968827724457,
-0.09070618450641632,
0.10971605032682419,
-0.14100486040115356,
0.20320911705493927,
0.03298920392990112,
-0.029491350054740906,
-0.22650004923343658,
-0.15000773966312408,
-0.2862881124019623,
0.10721202939748764,
-0.09674698859453201,
-0.15461412072181702,
-0.11205964535474777,
-0.13644371926784515,
-0.1774723082780838,
-0.18476836383342743,
-0.23297053575515747,
0.01455753855407238,
0.029499249532818794,
0.08502005785703659,
-0.03904671221971512,
0.1386304646730423,
-0.05792144313454628,
0.008438769727945328,
-0.11736787855625153,
-0.024429257959127426,
0.09309267997741699,
0.033813513815402985,
-0.015023907646536827,
0.07599728554487228,
0.04689581319689751,
-0.06161968410015106,
-0.04701203480362892,
-0.062428709119558334,
0.012228524312376976,
0.07188305258750916,
-0.14135229587554932,
-0.020829960703849792,
-0.028764626011252403,
0.27778929471969604,
-0.019682183861732483,
0.2009536474943161,
0.07314314693212509,
-0.09597005695104599
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , dystonia, choreoathetosis, or hemiplegia . The frequency of movement disorders in PA appears to be independent of the age of symptom onset .Psychiatric manifestations. The prevalence of other comorbidities such as attention deficit disorder, autism spectrum disorder, anxiety, and acute psychosis is incompletely characterized . Acute psychosis can be a presenting feature of PA in older individuals, especially in those not evaluated by newborn screen, thus warranting a high index of suspicion for this uncommon cause of psychosis in the general population .Brain MRI findings include delayed myelination, white matter changes, basal ganglia abnormalities, cerebellar hemorrhage, and cerebral atrophy . Clinically unstable individuals appear to be at higher risk of developing brain abnormalities. In a study of 17 PA individuals with clinical seizures, all had abnormal MRI findings and a history of more than ten metabolic decompensations . Magnetic resonance spectroscopy (MRS) can reveal decreased myoinositol, N-acetylaspartate and elevated Glx (glutamine, glutamate, and gamma-aminobutyric | [
-0.006137080956250429,
0.09497599303722382,
-0.1518459916114807,
-0.13799834251403809,
0.1816474348306656,
-0.012845940887928009,
-0.05547463893890381,
-0.16874904930591583,
-0.07513386756181717,
0.0745990127325058,
0.26932549476623535,
-0.0008355462341569364,
-0.0656474307179451,
0.07002460211515427,
-0.24781815707683563,
0.10736493766307831,
0.09292394667863846,
-0.06762207299470901,
-0.16353467106819153,
-0.0942157506942749,
-0.06101705878973007,
-0.1614435911178589,
0.13017402589321136,
0.05030081048607826,
0.12755317986011505,
-0.3477761149406433,
0.17969773709774017,
-0.26189860701560974,
0.25199517607688904,
0.22351445257663727,
-0.14434093236923218,
-0.0947243794798851,
0.13694331049919128,
-0.2021845132112503,
-0.09814773499965668,
-0.2458084225654602,
-0.1729264259338379,
-0.17000170052051544,
0.24807937443256378,
-0.15574193000793457,
-0.08457618951797485,
0.028915341943502426,
0.2848043441772461,
0.01820383220911026,
0.12723001837730408,
-0.03403284028172493,
-0.06987503916025162,
-0.15803715586662292,
-0.11212096363306046,
0.25207680463790894,
0.14316806197166443,
-0.13272236287593842,
-0.18252752721309662,
0.0554247610270977,
0.1704331636428833,
-0.02937311865389347,
-0.18673862516880035,
0.18238291144371033,
-0.2526276111602783,
0.22470657527446747,
0.09338418394327164,
-0.09814522415399551,
-0.12252721190452576,
-0.27876991033554077,
0.25140413641929626,
-0.04002153128385544,
-0.07942111045122147,
0.20162712037563324,
0.2568742632865906,
-0.15308921039104462,
0.02362094447016716,
-0.08115681260824203,
-0.006287435535341501,
0.1259770691394806,
-0.12924662232398987,
0.02303694561123848,
0.05091986432671547,
0.02086365967988968,
-0.0880608782172203,
-0.313402384519577,
-0.11606171727180481,
-0.022429369390010834,
-0.013166827149689198,
-0.07506182044744492,
-0.0922340378165245,
-0.041166167706251144,
0.186171755194664,
-0.0346863754093647,
-0.16391342878341675,
-0.08749838173389435,
0.17709127068519592,
0.12283743917942047,
-0.08898948132991791,
0.12123964726924896,
-0.06217016652226448,
0.10430160164833069,
0.12799158692359924,
0.03847520425915718,
-0.09966205060482025,
-0.007613048423081636,
0.13407649099826813,
0.08458324521780014,
-0.19747962057590485,
-0.09396785497665405,
0.07816113531589508,
-0.0009401199640706182,
0.000013685024896403775,
0.032283030450344086,
-0.06721840798854828,
0.023347964510321617,
0.031156782060861588,
-0.1753329336643219,
0.19134537875652313,
-0.060898616909980774,
-0.5557851195335388,
-0.05617663264274597,
-0.09991005808115005,
0.2744295597076416,
0.012431175448000431,
0.0583840012550354,
0.07052301615476608,
0.029087038710713387,
-0.06243737414479256,
0.1518431007862091,
0.08502152562141418,
0.09281569719314575,
0.13009877502918243,
0.022717038169503212,
0.24393019080162048,
0.008332327008247375,
0.05868760868906975,
-0.04520203173160553,
-0.06314460933208466,
-0.14895813167095184,
-0.09298421442508698,
-0.08759122341871262,
-0.4099729657173157,
-0.20531179010868073,
-0.007893489673733711,
-0.06365852057933807,
0.16625088453292847,
0.017385490238666534,
0.05332315340638161,
0.2620883882045746,
0.1017952486872673,
0.06455530971288681,
0.3394874334335327,
-0.04978016018867493,
0.27414509654045105,
0.02100786752998829,
0.046182092279195786,
-0.15426059067249298,
0.16069017350673676,
0.04029432311654091,
-0.149422749876976,
0.11436288803815842,
0.08918436616659164,
0.16541732847690582,
-0.09977149218320847,
0.020492523908615112,
-0.08654005080461502,
-0.032916661351919174,
-0.05782332643866539,
0.028037337586283684,
-0.21565960347652435,
0.1232817992568016,
-0.3787210285663605,
-0.08433685451745987,
0.13776899874210358,
-0.12601695954799652,
-0.08587471395730972,
0.07105748355388641,
-0.04179573431611061,
0.16668608784675598,
0.025642722845077515,
0.050199154764413834,
-0.060866620391607285,
0.2142730951309204,
-0.07529951632022858,
0.13959169387817383,
0.10656114667654037,
-0.15158352255821228,
-0.4736444652080536,
0.08730345964431763,
-0.024223510175943375,
-0.2519807815551758,
0.19418734312057495,
0.016483791172504425,
-0.1570606827735901,
0.056415215134620667,
0.10526524484157562,
0.14063535630702972,
-0.06437910348176956,
0.049659937620162964,
-0.17929331958293915,
-0.26448380947113037,
-0.06899400055408478,
-0.042322490364313126,
0.013119388371706009,
-0.05826328322291374,
-0.08428464829921722,
-0.1994638442993164,
0.05750555545091629,
-0.022855399176478386,
-0.13357146084308624,
0.0452863983809948,
-0.04600600525736809,
0.0083650853484869,
0.09012437611818314,
0.11966943740844727,
-0.2298649400472641,
0.27336809039115906,
-0.1588905155658722,
-0.1578352004289627,
-0.05919279158115387,
0.027620820328593254,
0.06018249690532684,
-0.09443468600511551,
-0.012431416660547256,
0.23072458803653717,
0.13248217105865479,
0.10449596494436264,
-0.0028053007554262877,
-0.190468892455101,
-0.19236156344413757,
-0.0009221441578119993,
-0.2818640172481537,
-0.08793415129184723,
0.2017643004655838,
-0.13765893876552582,
-0.3183375298976898,
0.14825087785720825,
-0.04769961163401604,
0.16412387788295746,
-0.0018527635838836432,
-0.3310282230377197,
-0.1566486805677414,
0.2263258546590805,
0.06282491236925125,
0.08043019473552704,
-0.3358753025531769,
0.02842072956264019,
0.004423267208039761,
-0.023334858939051628,
-0.08678009361028671,
0.11434546113014221,
0.021556934341788292,
0.05096184089779854,
-0.06544499099254608,
0.2620779275894165,
-0.08122454583644867,
0.15683355927467346,
0.029747867956757545,
0.07576945424079895,
-0.3181608021259308,
-0.1286839246749878,
0.012029031291604042,
-0.11643599718809128,
0.0727686882019043,
0.10145488381385803,
-0.0914335548877716,
0.3353171646595001,
-0.029692651703953743,
-0.055759284645318985,
-0.17478317022323608,
-0.11209134012460709,
-0.3062450587749481,
0.11631668359041214,
-0.12332566827535629,
-0.28055140376091003,
-0.15550287067890167,
0.27680206298828125,
0.12674839794635773,
-0.07407499104738235,
-0.27788257598876953,
-0.109537772834301,
0.22396163642406464,
0.09127821773290634,
0.18715646862983704,
0.1055789664387703,
-0.11698449403047562,
0.09334513545036316,
0.15831494331359863,
0.0670057013630867,
0.21612350642681122,
0.05320318043231964,
-0.0066468799486756325,
-0.0035090246237814426,
-0.038751691579818726,
0.17658133804798126,
0.0010293234372511506,
0.31130358576774597,
-0.19496650993824005,
-0.08863992989063263,
0.09407507628202438,
0.15313813090324402,
0.10974278301000595,
-0.12162027508020401,
-0.1538095623254776,
0.08270823955535889,
0.027889125049114227,
0.06611786782741547,
0.052574094384908676,
-0.04519246518611908,
-0.2548462450504303,
-0.028536418452858925,
0.019103558734059334,
-0.06606916338205338,
-0.06313887238502502,
0.11351411044597626,
-0.21072116494178772,
-0.16120308637619019,
0.02256426028907299,
-0.011580831371247768,
-0.22719284892082214,
-0.10313557833433151,
-0.04664723202586174,
0.15550342202186584,
0.11283183097839355,
0.18701894581317902,
0.056311123073101044,
0.016534339636564255,
0.06199212372303009,
0.1347985863685608,
-0.15595044195652008,
0.09042653441429138,
-0.15386028587818146,
0.13909770548343658,
-0.058077193796634674,
0.07193267345428467,
-0.015536473132669926,
0.08831096440553665,
-0.12085752934217453,
-0.24221305549144745,
0.20183387398719788,
-0.051854271441698074,
0.3618813455104828,
0.10782445222139359,
-0.283785879611969,
0.014137119986116886,
0.29486098885536194,
-0.39457887411117554,
-0.1912750005722046,
-0.27014678716659546,
-0.09690827876329422,
0.1566900908946991,
-0.11067843437194824,
0.10464000701904297,
0.18358050286769867,
-0.002845949726179242,
-0.14881861209869385,
-0.056143537163734436,
-0.05397931486368179,
-0.07611634582281113,
0.11551828682422638,
-0.0917164608836174,
-0.025970004498958588,
0.05585809797048569,
0.2230118215084076,
-0.01406557485461235,
-0.27343040704727173,
0.08306683599948883,
0.031472623348236084,
-0.20756493508815765,
0.18881955742835999,
-0.29446840286254883,
-0.02779344841837883,
0.053002700209617615,
0.3093521296977997,
-0.020287184044718742,
0.0798722580075264,
0.12900310754776,
-0.031121212989091873,
0.1952173262834549,
-0.22110961377620697,
0.05191846191883087,
-0.15603435039520264,
-0.05074489489197731,
-0.2222806215286255,
-0.019696757197380066,
0.18612736463546753,
0.13973206281661987,
0.12068410217761993,
0.10777431726455688,
0.025771360844373703,
-0.056576501578092575,
-0.17345504462718964,
0.23844727873802185,
0.3910292685031891,
-0.5647462010383606,
-0.0708031952381134,
0.2043188065290451,
-0.03850105032324791,
0.27880847454071045,
0.09297889471054077,
0.15980584919452667,
-0.01345808058977127,
0.14259038865566254,
-0.08540552854537964,
0.16346845030784607,
-0.007287351880222559,
0.03984007239341736,
0.29034164547920227,
0.028314536437392235,
0.06992129981517792,
0.18176591396331787,
0.034112971276044846,
0.2955101430416107,
-0.18681694567203522,
0.06056133657693863,
0.03283316269516945,
-0.1652686595916748,
-0.11087531596422195,
-0.0079763513058424,
-0.1725703328847885,
-0.15876653790473938,
-0.1182829812169075,
0.03701247274875641,
0.1430608332157135,
-0.11788318306207657,
-0.2052329182624817,
-0.02803821489214897,
0.002188309095799923,
0.08978672325611115,
-0.20224067568778992,
0.1514602154493332,
-0.06896033883094788,
-0.023323550820350647,
0.21084147691726685,
0.12314198911190033,
0.24363699555397034,
-0.035179637372493744,
-0.014800311997532845,
0.06217995658516884,
0.1346587836742401,
0.1279057413339615,
-0.1688687950372696,
0.017922528088092804,
-0.04447989538311958,
-0.13599978387355804,
0.07350512593984604,
0.06453677266836166,
0.03144536539912224,
-0.10892006754875183,
-0.05705179274082184,
0.040549084544181824,
0.2880586087703705,
-0.015863047912716866,
-0.12576235830783844,
-0.02465927228331566,
0.0056171417236328125,
-0.0272650308907032,
-0.15393760800361633,
0.05136862024664879,
0.10336929559707642,
0.1397377997636795,
0.16800925135612488,
-0.011810067109763622,
-0.020751016214489937,
0.00861760601401329,
-0.12712468206882477,
0.003382574301213026,
0.3649200201034546,
-0.06430037319660187,
-0.1455322802066803,
0.16780991852283478,
-0.17324261367321014,
0.10351582616567612,
-0.04063406214118004,
-0.025814566761255264,
0.03863503411412239,
0.031342752277851105,
-0.20597679913043976,
0.019609201699495316,
-0.14598271250724792,
-0.20948395133018494,
-0.06061885878443718,
0.07682468742132187,
-0.08390548825263977,
0.09829254448413849,
-0.011180359870195389,
-0.152533158659935,
0.06280142068862915,
0.13920532166957855,
-0.15737797319889069,
0.28863608837127686,
-0.24206969141960144,
0.05977654829621315,
0.49963346123695374,
0.09094911068677902,
0.08933959156274796,
0.06924032419919968,
0.013018903322517872,
0.34486085176467896,
-0.013064460828900337,
-0.24949346482753754,
0.015138991177082062,
-0.15958952903747559,
-0.013951512984931469,
-0.13195131719112396,
-0.013471286743879318,
-0.0365603081882,
-0.1623457670211792,
-0.013270251452922821,
-0.0927296131849289,
-0.07322654128074646,
-0.06844545900821686,
-0.21348434686660767,
0.018168410286307335,
0.16080819070339203,
-0.00892793107777834,
0.10936660319566727,
0.04294934868812561,
-0.04297686368227005,
0.03309458866715431,
-0.28693336248397827,
0.1789824515581131,
0.27758073806762695,
0.027897998690605164,
-0.2422664910554886,
0.09021857380867004,
0.07533901184797287,
0.20231160521507263,
-0.11472271382808685,
0.1180608719587326,
-0.1518947184085846,
0.18329355120658875,
0.08924664556980133,
-0.009080599993467331,
-0.11458572745323181,
0.08047817647457123,
-0.12598922848701477,
-0.2122623175382614,
-0.05725010111927986,
0.17743228375911713,
-0.21468250453472137,
-0.04748568311333656,
-0.2053469866514206,
0.06995589286088943,
-0.06755979359149933,
-0.14043818414211273,
0.018355296924710274,
-0.08781654387712479,
0.11245936900377274,
-0.16016733646392822,
0.15847785770893097,
0.22326545417308807,
0.11974651366472244,
0.263166218996048,
0.01986292004585266,
-0.10027538239955902,
-0.12508007884025574,
0.007806949783116579,
0.1124906986951828,
0.02545228973031044,
-0.12066051363945007,
-0.025180481374263763,
-0.11086093634366989,
-0.1865578442811966,
0.06274064630270004,
0.022136004641652107,
-0.1140173003077507,
-0.11198660731315613,
0.19889703392982483,
-0.03183363378047943,
0.2585275173187256,
-0.12544089555740356,
-0.11166881769895554,
0.07744782418012619,
-0.18852345645427704,
0.21685853600502014,
0.10208050906658173,
-0.032566316425800323,
0.025926927104592323,
-0.03886140510439873,
0.11259891092777252,
-0.2776399850845337,
-0.19224832952022552,
-0.14290675520896912,
0.008936695754528046,
-0.03454376384615898,
-0.15003272891044617,
0.20902813971042633,
-0.21210938692092896,
0.14959420263767242,
-0.010017570108175278,
0.20235656201839447,
-0.03894513100385666,
0.2550652027130127,
-0.023660382255911827,
-0.06021057441830635,
-0.16098922491073608,
0.06299002468585968,
0.05074150115251541,
0.11630315333604813,
-0.11497359722852707,
0.1872127205133438,
-0.166603222489357,
0.14757712185382843,
0.08803750574588776,
0.24766120314598083,
0.13383859395980835,
0.0014085749862715602,
-0.12741319835186005,
-0.09997428953647614,
-0.1330554187297821,
0.25931888818740845,
-0.36666378378868103,
-0.07656130939722061,
0.04226376488804817,
0.15608137845993042,
0.13945522904396057,
0.27377602458000183,
-0.12070547789335251,
0.19851674139499664,
0.07124510407447815,
0.2373095601797104,
0.06713838130235672,
0.06584635376930237,
0.022026577964425087,
0.3661806285381317,
0.0286796223372221,
0.2253831923007965,
-0.01036310289055109,
-0.24603915214538574,
0.10177119076251984,
0.009881643578410149,
0.12134633213281631,
0.036623843014240265,
0.02341439761221409,
0.026059547439217567,
0.24275849759578705,
0.060027576982975006,
0.06115278974175453,
-0.14548003673553467,
0.011546232737600803,
0.1601494699716568,
0.061190105974674225,
-0.1566786915063858,
0.09982611984014511,
-0.3409152328968048,
0.05031789094209671,
-0.07918902486562729,
0.10777811706066132,
-0.18681514263153076,
0.005700874142348766,
-0.043614987283945084,
-0.3175159990787506,
-0.17753340303897858,
-0.2511202096939087,
0.06108447164297104,
-0.044460661709308624,
-0.1535004824399948,
0.22456392645835876,
0.12164977937936783,
-0.13204874098300934,
-0.0467677041888237,
-0.11889300495386124,
0.20728714764118195,
-0.057330794632434845,
-0.06642886996269226,
0.057953547686338425,
0.19572846591472626,
-0.04759259521961212,
-0.08282645791769028,
0.16683904826641083,
0.17399822175502777,
-0.06524957716464996,
0.08465880155563354,
-0.3047213852405548,
-0.2696208953857422,
-0.02174490876495838,
-0.050182778388261795,
-0.04260571673512459,
0.0021721674129366875,
0.0022830802481621504,
-0.10389544069766998,
0.16839399933815002,
-0.12308775633573532,
0.28777968883514404,
0.16496001183986664,
-0.374997615814209,
-0.059866853058338165,
-0.07147572189569473,
0.13203200697898865,
0.11679369956254959,
0.08427879959344864,
0.10212507843971252,
0.15455394983291626,
-0.24387066066265106,
0.13395455479621887,
-0.019438598304986954,
0.16948537528514862,
0.13250179588794708,
-0.08901426941156387,
-0.015088219195604324,
0.2901383936405182,
-0.2783941328525543,
-0.2983664572238922,
-0.09140285849571228,
-0.19642125070095062,
-0.05807926133275032,
-0.023761849850416183,
0.07607034593820572,
-0.07969675958156586,
-0.055796895176172256,
0.10515175759792328,
-0.19728700816631317,
0.0702233761548996,
-0.20454785227775574,
-0.11115674674510956,
-0.09897004067897797,
-0.0908326655626297,
0.18310396373271942,
-0.06740765273571014,
0.128286674618721,
0.07494830340147018,
0.05434248223900795,
-0.0052070580422878265,
-0.24830947816371918,
0.11706022173166275,
0.05134536325931549,
0.058024391531944275,
0.0009644708479754627,
-0.08456721901893616,
0.04209402576088905,
-0.05124365910887718,
0.14413848519325256,
0.13673406839370728,
0.0630255937576294,
-0.23876135051250458,
-0.07941123098134995,
-0.3167130947113037,
0.008684374392032623,
-0.015146123245358467,
-0.16974438726902008,
-0.03855167329311371,
-0.15907233953475952,
-0.09131412208080292,
-0.0721040666103363,
-0.10332712531089783,
0.08716294914484024,
0.13013552129268646,
-0.021020077168941498,
-0.10200262069702148,
0.018423764035105705,
0.054168011993169785,
-0.009565762244164944,
-0.0471407026052475,
-0.19230332970619202,
0.03275321424007416,
0.17520393431186676,
0.16710637509822845,
0.025821538642048836,
0.06599588692188263,
-0.061507098376750946,
-0.18781064450740814,
-0.07776100188493729,
0.02165537141263485,
0.03391878679394722,
-0.2364182025194168,
-0.059257350862026215,
-0.10206997394561768,
0.22284038364887238,
0.052529338747262955,
0.2908113896846771,
0.09495115280151367,
0.012050667777657509
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. psychosis in the general population .Brain MRI findings include delayed myelination, white matter changes, basal ganglia abnormalities, cerebellar hemorrhage, and cerebral atrophy . Clinically unstable individuals appear to be at higher risk of developing brain abnormalities. In a study of 17 PA individuals with clinical seizures, all had abnormal MRI findings and a history of more than ten metabolic decompensations . Magnetic resonance spectroscopy (MRS) can reveal decreased myoinositol, N-acetylaspartate and elevated Glx (glutamine, glutamate, and gamma-aminobutyric acid) peaks in basal ganglia .Cardiomyopathy has been recognized as a common complication of PA. Both dilated and hypertrophic cardiomyopathy have been reported . In the period between 2000 and 2015, its reported prevalence varied between 7% and 24% in various PA cohorts .Early clinical manifestations of cardiomyopathy include tachypnea, hepatomegaly, hypotension, tachycardia, or bradycardia.The mean age of onset of cardiomyopathy was seven years in a study by Romano et al .The age of PA diagnosis | [
0.08439336717128754,
0.16290779411792755,
-0.09674446284770966,
-0.18739721179008484,
0.11256294697523117,
-0.0572269931435585,
-0.06079444661736488,
-0.11203466355800629,
0.008665889501571655,
0.061517275869846344,
0.09605096280574799,
0.09779049456119537,
-0.025876086205244064,
0.06157144531607628,
-0.27446091175079346,
0.06205378845334053,
0.028833668678998947,
0.0833803340792656,
-0.14702576398849487,
-0.113076351583004,
-0.0546499565243721,
-0.19556540250778198,
0.09446530044078827,
-0.038209326565265656,
0.05550451949238777,
-0.2982911467552185,
0.20231029391288757,
-0.2347874939441681,
0.16735059022903442,
0.28783705830574036,
-0.02768215909600258,
-0.05300931632518768,
0.0693444013595581,
-0.21248219907283783,
-0.09653542935848236,
-0.21990375220775604,
-0.22922152280807495,
-0.2652299106121063,
0.2274496704339981,
-0.24830596148967743,
-0.08396649360656738,
-0.02356431446969509,
0.2954331934452057,
-0.016921574249863625,
0.22403964400291443,
-0.11131636798381805,
-0.033339254558086395,
-0.020298395305871964,
-0.06995312869548798,
0.2520661950111389,
0.15422990918159485,
-0.1590898483991623,
-0.11238919943571091,
0.02540542185306549,
0.2369520366191864,
0.00857365783303976,
-0.16872543096542358,
0.025684291496872902,
-0.18483322858810425,
0.21806634962558746,
0.12296244502067566,
-0.2415369600057602,
-0.1395907700061798,
-0.36136460304260254,
0.12280808389186859,
-0.14722014963626862,
0.05939938873052597,
0.19682055711746216,
0.29726192355155945,
0.06913214921951294,
0.16391195356845856,
-0.21607369184494019,
-0.01625950075685978,
0.1772194802761078,
-0.09529805183410645,
0.06838531792163849,
0.0803140252828598,
-0.009761195629835129,
-0.13574686646461487,
-0.157417431473732,
-0.24235549569129944,
0.062013525515794754,
-0.01977810263633728,
-0.15621842443943024,
0.0012013817904517055,
0.10290714353322983,
0.23931552469730377,
-0.0175558403134346,
-0.08744163811206818,
0.009017561562359333,
0.20295965671539307,
0.0850692167878151,
-0.10439278185367584,
-0.07037109136581421,
0.054155606776475906,
0.16978077590465546,
0.1411137878894806,
-0.01941009610891342,
-0.13830478489398956,
0.06287302076816559,
0.10765614360570908,
0.1257058084011078,
-0.18082603812217712,
-0.054935626685619354,
0.02030588686466217,
-0.08333991467952728,
-0.04586837440729141,
0.07075820863246918,
-0.04277806729078293,
0.10385201126337051,
0.07336185872554779,
-0.23189900815486908,
0.11237107217311859,
-0.11798547953367233,
-0.48608964681625366,
0.09921719878911972,
-0.12351080030202866,
0.2980160713195801,
0.039468299597501755,
0.08831221610307693,
0.10339213162660599,
-0.048561859875917435,
-0.05134957656264305,
0.23434190452098846,
0.09502270817756653,
0.10642785578966141,
0.04857185482978821,
-0.019770270213484764,
0.2802487909793854,
0.015819629654288292,
0.14911319315433502,
0.1110137552022934,
-0.02701847441494465,
-0.1389487087726593,
0.039695512503385544,
-0.07967450469732285,
-0.3655298352241516,
-0.26733845472335815,
-0.08202637732028961,
-0.0800853818655014,
0.12208914011716843,
0.07818498462438583,
0.2110428512096405,
0.3443705439567566,
0.16917164623737335,
0.01784893497824669,
0.23521143198013306,
-0.11379861831665039,
0.30241966247558594,
0.024006038904190063,
-0.018381871283054352,
-0.2965225577354431,
0.10123509168624878,
0.09394091367721558,
-0.13730067014694214,
0.09131524711847305,
0.06474699079990387,
0.10329314321279526,
-0.13101385533809662,
-0.01801057532429695,
-0.10124628245830536,
0.00834039505571127,
-0.1146727129817009,
0.014285090379416943,
-0.00027558711008168757,
-0.0029929624870419502,
-0.27274030447006226,
-0.03863554447889328,
0.0854174941778183,
-0.12637868523597717,
-0.050352439284324646,
0.10465217381715775,
0.02999921515583992,
-0.011647904291749,
0.0221461970359087,
0.02339252270758152,
0.03276742622256279,
0.2212420254945755,
-0.19620081782341003,
0.0478430800139904,
0.1174350455403328,
-0.037829019129276276,
-0.5190143585205078,
0.0431179478764534,
-0.08260219544172287,
-0.17237289249897003,
0.11592038720846176,
0.13429856300354004,
-0.14276669919490814,
0.10737062990665436,
0.09181618690490723,
0.116123266518116,
0.02680947631597519,
0.23388490080833435,
-0.14171718060970306,
-0.3379114270210266,
0.014382373541593552,
-0.13189150393009186,
0.014793687500059605,
-0.13534529507160187,
-0.006926067639142275,
-0.23643289506435394,
0.130895733833313,
0.034554969519376755,
-0.07472315430641174,
-0.06515314429998398,
0.045660801231861115,
-0.09024860709905624,
0.06478407233953476,
0.10512486845254898,
-0.24758557975292206,
0.2515096366405487,
-0.24646855890750885,
-0.15103861689567566,
-0.1452561765909195,
-0.03966294229030609,
0.036524876952171326,
0.005947907920926809,
0.07554804533720016,
0.13054604828357697,
0.08442675322294235,
0.015362071804702282,
0.016912562772631645,
-0.1914375275373459,
-0.20833133161067963,
0.037656404078006744,
-0.32822632789611816,
-0.004787851590663195,
0.021277140825986862,
-0.12040328979492188,
-0.23965924978256226,
0.1266140341758728,
-0.08220254629850388,
0.17844563722610474,
-0.040881071239709854,
-0.20544202625751495,
-0.21725082397460938,
0.20708294212818146,
-0.02452017366886139,
-0.11357174068689346,
-0.30496135354042053,
-0.009419041685760021,
0.0751025378704071,
-0.041782282292842865,
-0.09166970103979111,
0.0038563332054764032,
-0.0809500589966774,
0.1460724174976349,
0.018177766352891922,
0.22815857827663422,
-0.06402109563350677,
0.2076757550239563,
0.1443198323249817,
0.16637082397937775,
-0.3688948452472687,
-0.2366415560245514,
-0.010176070965826511,
0.036372095346450806,
0.10799939930438995,
-0.012888549827039242,
-0.14610861241817474,
0.24744391441345215,
-0.12203580141067505,
0.02349829487502575,
-0.12006869167089462,
-0.17319375276565552,
-0.2360529899597168,
0.10455412417650223,
-0.09441123902797699,
-0.23534302413463593,
-0.08648833632469177,
0.2742258608341217,
0.22476457059383392,
-0.08569221943616867,
-0.31129443645477295,
-0.06817438453435898,
0.25062596797943115,
0.06800109148025513,
0.1970554143190384,
-0.05950431898236275,
-0.12488889694213867,
0.06509536504745483,
-0.004696770571172237,
0.08124470710754395,
0.23594878613948822,
-0.0778438150882721,
0.010963834822177887,
0.01648572087287903,
-0.09979383647441864,
0.1770038604736328,
0.06453405320644379,
0.30958327651023865,
-0.06802769005298615,
-0.03920967876911163,
0.1401183307170868,
0.16929686069488525,
0.02362102083861828,
-0.14520809054374695,
0.05608617886900902,
0.013708884827792645,
0.1613425761461258,
0.052250832319259644,
0.18635693192481995,
0.03367752581834793,
-0.22423195838928223,
-0.03244991973042488,
-0.0692729577422142,
0.02223365567624569,
0.040730610489845276,
0.24764478206634521,
-0.10897667706012726,
-0.1772882491350174,
-0.036978330463171005,
-0.09559191763401031,
-0.08381123095750809,
-0.07441796362400055,
0.04869871586561203,
0.06702779978513718,
0.11137743294239044,
0.3133399486541748,
0.001479260390624404,
0.09052018076181412,
0.0893736183643341,
0.14813785254955292,
-0.28067734837532043,
-0.054621778428554535,
0.013991611078381538,
0.1659921407699585,
0.007447652518749237,
0.17771771550178528,
-0.03261822462081909,
0.14881455898284912,
-0.07815344631671906,
-0.19527781009674072,
0.26058781147003174,
-0.14199897646903992,
0.32041487097740173,
0.06197891756892204,
-0.1790490299463272,
-0.0367140956223011,
0.23507599532604218,
-0.3609744906425476,
-0.09872236102819443,
-0.34250739216804504,
-0.24506419897079468,
0.15277355909347534,
0.07654912769794464,
0.07582985609769821,
0.10757539421319962,
-0.1132279559969902,
-0.07264105975627899,
-0.01975899189710617,
-0.14450155198574066,
0.023231377825140953,
0.06990177929401398,
-0.12488026171922684,
-0.12586431205272675,
0.03444299101829529,
0.27547478675842285,
0.020390164107084274,
-0.23205974698066711,
0.048936232924461365,
0.1149635910987854,
-0.13682620227336884,
0.027994461357593536,
-0.23487718403339386,
-0.06964872777462006,
0.1152859553694725,
0.21209338307380676,
-0.09230135381221771,
-0.009809625335037708,
-0.020318787544965744,
-0.024648917838931084,
0.20454412698745728,
-0.10071676969528198,
0.10351669788360596,
-0.19257651269435883,
-0.17379538714885712,
-0.1616547852754593,
-0.006295877508819103,
0.13399501144886017,
0.13356423377990723,
0.01408312562853098,
0.19807149469852448,
-0.019504722207784653,
-0.10600925981998444,
-0.17816218733787537,
0.18443253636360168,
0.4320068359375,
-0.47292360663414,
-0.1032087430357933,
0.2308761030435562,
-0.08782905340194702,
0.19292807579040527,
0.21196778118610382,
0.14202439785003662,
0.010155336000025272,
0.21236762404441833,
-0.19620154798030853,
0.12666457891464233,
0.03764073923230171,
0.19375666975975037,
0.3642682433128357,
0.02174444869160652,
0.09302016347646713,
0.10113108158111572,
0.15828856825828552,
0.30665355920791626,
-0.16308948397636414,
0.08437561988830566,
-0.08785779774188995,
-0.20720772445201874,
-0.050597578287124634,
-0.05910830944776535,
-0.12511739134788513,
-0.20472030341625214,
-0.1047358289361,
0.16489200294017792,
0.19669727981090546,
-0.10555631667375565,
-0.14412499964237213,
-0.06111143156886101,
-0.12183134257793427,
0.11465273797512054,
-0.2897684574127197,
0.16131731867790222,
0.0836450532078743,
-0.08125295490026474,
0.07977499067783356,
0.08733540773391724,
0.17245228588581085,
-0.07238073647022247,
-0.02435350976884365,
0.15621834993362427,
0.20087717473506927,
0.2319519966840744,
-0.23069503903388977,
-0.07431724667549133,
-0.12501870095729828,
-0.16931940615177155,
0.0979078933596611,
-0.004986129701137543,
-0.1497594267129898,
-0.23606611788272858,
-0.10102017223834991,
0.1242692768573761,
0.3047751486301422,
0.061117593199014664,
-0.04939702898263931,
0.05686357244849205,
0.061160895973443985,
-0.09842955321073532,
-0.03062753938138485,
0.20085030794143677,
0.05678235739469528,
0.20126448571681976,
0.23268409073352814,
0.03875928744673729,
-0.09382820874452591,
-0.1075112521648407,
-0.140762060880661,
-0.026806920766830444,
0.25282397866249084,
-0.05489835515618324,
-0.13360124826431274,
0.046437881886959076,
-0.2106970101594925,
-0.04549887031316757,
0.03932290896773338,
-0.061456579715013504,
0.08191580325365067,
0.08386003971099854,
-0.1762198954820633,
0.1524132490158081,
-0.18666206300258636,
-0.26874926686286926,
-0.12412341684103012,
-0.12864290177822113,
-0.12416061758995056,
-0.020945416763424873,
-0.05693267658352852,
-0.2067248374223709,
0.060176145285367966,
0.13425152003765106,
-0.22584663331508636,
0.1905403882265091,
-0.2774900496006012,
0.013877274468541145,
0.44664841890335083,
0.05126655101776123,
0.04900228977203369,
-0.12432557344436646,
0.03239649906754494,
0.4373623728752136,
-0.0759119838476181,
-0.4456624686717987,
0.13204079866409302,
0.04236937314271927,
-0.00792195089161396,
-0.0897991806268692,
-0.07217946648597717,
-0.2112271934747696,
-0.1789606511592865,
-0.1148812398314476,
-0.11427057534456253,
-0.05901027470827103,
-0.04025314003229141,
-0.21527405083179474,
0.018011830747127533,
0.15628837049007416,
0.10924533009529114,
-0.012388521805405617,
0.0562368705868721,
-0.004469879437237978,
0.04026321694254875,
-0.3682427704334259,
0.15493303537368774,
0.19223307073116302,
0.018231654539704323,
-0.3277294337749481,
0.11898857355117798,
0.062259986996650696,
0.22476235032081604,
-0.05970273166894913,
0.2210720181465149,
-0.0897735208272934,
0.10413073003292084,
0.060702502727508545,
0.10356935113668442,
-0.14677755534648895,
-0.08534642308950424,
-0.08931168168783188,
-0.1927207112312317,
0.006336319260299206,
0.24961844086647034,
-0.05379734933376312,
-0.08794350177049637,
-0.22094471752643585,
0.2786799371242523,
-0.07289808243513107,
-0.19553013145923615,
-0.035722147673368454,
-0.02132873609662056,
0.20086359977722168,
-0.11731161177158356,
0.17030726373195648,
0.26001647114753723,
0.17414158582687378,
0.13984355330467224,
-0.04413479194045067,
-0.09930901229381561,
-0.20995384454727173,
-0.043224625289440155,
0.027456648647785187,
-0.041240330785512924,
-0.13659287989139557,
-0.05890341475605965,
-0.12032052129507065,
-0.23783443868160248,
0.05529499799013138,
-0.021533016115427017,
-0.12329845875501633,
-0.26296737790107727,
0.2104496955871582,
-0.061729781329631805,
0.10940065234899521,
-0.11451824009418488,
-0.04436074569821358,
0.15029023587703705,
-0.15924334526062012,
0.18279609084129333,
0.1380937099456787,
0.18228581547737122,
-0.0016243674326688051,
-0.28209319710731506,
0.20438027381896973,
-0.28065815567970276,
-0.34727153182029724,
-0.13874894380569458,
0.06287328153848648,
0.04772081971168518,
-0.0825236439704895,
0.15826241672039032,
-0.1265137642621994,
0.20869705080986023,
0.1313409060239792,
0.09581724554300308,
-0.04337465763092041,
0.2975468039512634,
-0.0035417089238762856,
-0.023465333506464958,
-0.12855762243270874,
0.0344817191362381,
0.04188689962029457,
0.15232671797275543,
-0.10795579850673676,
0.12608163058757782,
-0.22575165331363678,
-0.017961593344807625,
0.1578315645456314,
0.18790003657341003,
0.25449851155281067,
0.031522125005722046,
-0.1327868551015854,
-0.16637426614761353,
-0.04521720111370087,
0.21179714798927307,
-0.44193294644355774,
-0.07595011591911316,
-0.028452612459659576,
0.23338399827480316,
0.14354172348976135,
0.18990834057331085,
-0.07816863059997559,
0.22607974708080292,
0.020471254363656044,
0.236679807305336,
0.034098416566848755,
0.19048891961574554,
0.0025103921070694923,
0.37364423274993896,
0.0021293770987540483,
0.19314445555210114,
-0.06418772041797638,
-0.19235767424106598,
0.08105463534593582,
0.04209592938423157,
-0.12214705348014832,
0.03955883905291557,
-0.09535234421491623,
-0.11277417838573456,
0.18536190688610077,
0.13140755891799927,
-0.08124327659606934,
-0.11637330800294876,
0.10514447838068008,
0.11528771370649338,
0.23955249786376953,
-0.19551430642604828,
0.12375806272029877,
-0.3802723288536072,
0.19035682082176208,
-0.15459148585796356,
0.020570820197463036,
-0.14553643763065338,
0.023335548117756844,
-0.05083850398659706,
-0.2623295783996582,
-0.2033635526895523,
-0.2296203076839447,
0.2082257866859436,
-0.06889159977436066,
-0.21834421157836914,
0.1884758025407791,
0.2779342830181122,
-0.14425010979175568,
-0.03997793048620224,
-0.057995762676000595,
0.23731333017349243,
0.009258294478058815,
-0.00385588058270514,
0.24529394507408142,
0.13031622767448425,
0.04093281924724579,
-0.1482180505990982,
0.08048821240663528,
0.0709897130727768,
-0.07004503905773163,
-0.009069271385669708,
-0.20921477675437927,
-0.2921663522720337,
0.015568380244076252,
-0.05929595232009888,
-0.13142970204353333,
-0.007680069655179977,
0.05544497072696686,
-0.08551374822854996,
0.15983784198760986,
-0.164280503988266,
0.3818213641643524,
0.14995694160461426,
-0.35421276092529297,
-0.05739998072385788,
-0.09011507034301758,
0.16835245490074158,
0.10705341398715973,
0.07331570982933044,
0.09765277057886124,
0.13622334599494934,
-0.15758487582206726,
0.14818738400936127,
-0.06318411976099014,
0.16269272565841675,
0.18151676654815674,
-0.14654812216758728,
0.00932071078568697,
0.2715034484863281,
-0.2699793577194214,
-0.3322455883026123,
-0.08586917072534561,
-0.20179831981658936,
-0.019219672307372093,
0.17392899096012115,
0.08362704515457153,
-0.1762012243270874,
-0.016722362488508224,
0.1203354224562645,
-0.19251814484596252,
-0.06106410175561905,
-0.17100083827972412,
-0.09821660816669464,
-0.15804411470890045,
-0.04026002064347267,
0.2027388960123062,
-0.13845673203468323,
0.05802978202700615,
0.07836504280567169,
0.20966342091560364,
-0.08474711328744888,
-0.3201353847980499,
0.07488734275102615,
0.1692190170288086,
0.0036241053603589535,
-0.03164266422390938,
-0.09520359337329865,
0.01591229811310768,
-0.04097630828619003,
0.15319547057151794,
0.05221601948142052,
0.06864601373672485,
-0.2499936819076538,
-0.13312529027462006,
-0.31413716077804565,
-0.03952253982424736,
-0.1532023847103119,
-0.17992033064365387,
-0.035869382321834564,
-0.1654963344335556,
-0.09949736297130585,
-0.09567958861589432,
-0.08657731860876083,
0.1662728637456894,
0.153410404920578,
0.024627091363072395,
0.037472356110811234,
0.10338804870843887,
0.08471248298883438,
0.028111759573221207,
-0.03203030675649643,
-0.09588032960891724,
-0.02172880992293358,
0.22460909187793732,
0.18093149363994598,
0.08064153045415878,
0.10109169781208038,
0.055941492319107056,
-0.20731478929519653,
0.005497021600604057,
0.021049395203590393,
0.0720602497458458,
-0.2330823540687561,
-0.09998437017202377,
-0.08057708293199539,
0.18505379557609558,
-0.059200186282396317,
0.30169203877449036,
0.1495935469865799,
0.019474130123853683
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. glutamate, and gamma-aminobutyric acid) peaks in basal ganglia .Cardiomyopathy has been recognized as a common complication of PA. Both dilated and hypertrophic cardiomyopathy have been reported . In the period between 2000 and 2015, its reported prevalence varied between 7% and 24% in various PA cohorts .Early clinical manifestations of cardiomyopathy include tachypnea, hepatomegaly, hypotension, tachycardia, or bradycardia.The mean age of onset of cardiomyopathy was seven years in a study by Romano et al .The age of PA diagnosis, frequency of metabolic decompensation, and residual enzymatic activity do not correlate with presence/absence of cardiomyopathy in individuals with PA .Rarely, cardiomyopathy can occur as an apparently isolated clinical phenomenon in previously healthy individuals without documented episodes of metabolic decompensation or neurocognitive deficits .Cardiomyopathy can progress to cardiac failure and may be associated with sudden death .Cardiac rhythm abnormalities. A prolonged QT interval is often detected in individuals with PA . This can be associated with syncope, arrhythmia, and cardiac arrest .Gastrointestinal manifestations | [
0.27843010425567627,
0.22506995499134064,
-0.11490444839000702,
-0.19008633494377136,
-0.0026031245943158865,
-0.12433379888534546,
-0.021422255784273148,
-0.06623074412345886,
0.0250770952552557,
-0.08908706903457642,
0.1122450903058052,
0.051397308707237244,
-0.023156261071562767,
0.10699339956045151,
-0.17086002230644226,
0.0844348594546318,
-0.007411183323711157,
0.1721150279045105,
-0.029872657731175423,
-0.19464212656021118,
-0.07148468494415283,
-0.2599470615386963,
0.10831385850906372,
-0.01771385408937931,
0.044715456664562225,
-0.30244314670562744,
0.13998885452747345,
-0.2709560692310333,
0.1279757171869278,
0.16663110256195068,
0.09264592826366425,
0.06783328950405121,
0.06902451813220978,
-0.25246861577033997,
0.042857591062784195,
-0.21393348276615143,
-0.1998061090707779,
-0.1881776601076126,
0.18423153460025787,
-0.22116389870643616,
-0.09392135590314865,
-0.0776391327381134,
0.11037299036979675,
-0.09541931003332138,
0.2632730007171631,
-0.1287807822227478,
-0.02230624295771122,
0.003803806845098734,
-0.1075524166226387,
0.15620999038219452,
0.10592169314622879,
-0.24763710796833038,
-0.10659470409154892,
0.09383566677570343,
0.26291343569755554,
0.008115812204778194,
-0.1120753064751625,
0.010739156045019627,
-0.12455729395151138,
0.262101411819458,
0.23355190455913544,
-0.14500422775745392,
-0.20664848387241364,
-0.3850155472755432,
0.14655420184135437,
-0.1478331834077835,
0.037125203758478165,
0.28758561611175537,
0.2907472848892212,
0.08984020352363586,
0.20099429786205292,
-0.27041739225387573,
-0.06167677789926529,
0.21431194245815277,
0.021872282028198242,
0.01111350767314434,
0.06007714569568634,
-0.07261476665735245,
-0.10858866572380066,
-0.0930790826678276,
-0.21150889992713928,
0.02577160857617855,
-0.04840068891644478,
-0.15141195058822632,
0.013373520225286484,
0.17622826993465424,
0.2182694971561432,
0.05378744751214981,
-0.12803791463375092,
0.011514752171933651,
0.24849198758602142,
0.07185983657836914,
-0.16272850334644318,
-0.1344687044620514,
0.1332540363073349,
0.18008877336978912,
0.1732935756444931,
0.029164014384150505,
-0.10608113557100296,
0.18677489459514618,
-0.08464175462722778,
0.09280553460121155,
-0.12746436893939972,
0.09503668546676636,
-0.03864780813455582,
0.10605082660913467,
-0.03128807619214058,
0.07438331097364426,
-0.1402023583650589,
0.18556520342826843,
0.06988223642110825,
-0.05664905905723572,
0.13622799515724182,
-0.23867744207382202,
-0.3482336103916168,
0.21563944220542908,
-0.005651837680488825,
0.300324022769928,
0.12857219576835632,
-0.07753133773803711,
0.03924047574400902,
-0.07297269999980927,
-0.04023207724094391,
0.11338191479444504,
0.03256365656852722,
-0.01085579302161932,
0.028645344078540802,
-0.0360645093023777,
0.3073066473007202,
0.043335460126399994,
0.17336004972457886,
0.14398881793022156,
-0.09467630088329315,
-0.07617814093828201,
0.25753816962242126,
-0.08651075512170792,
-0.40383780002593994,
-0.3583891689777374,
-0.09535606950521469,
-0.08643009513616562,
0.13880504667758942,
0.008431771770119667,
0.14175400137901306,
0.3203306496143341,
0.16059613227844238,
-0.004750908352434635,
0.21394677460193634,
0.0036271079443395138,
0.3549918830394745,
0.09480912983417511,
-0.16025754809379578,
-0.33286070823669434,
0.08794904500246048,
0.09994304180145264,
-0.09216605871915817,
0.049706149846315384,
-0.035143811255693436,
0.05620928108692169,
-0.1998603343963623,
0.03372467681765556,
-0.12297191470861435,
-0.08378081023693085,
-0.06842364370822906,
0.05928187072277069,
0.08140140771865845,
0.02849726565182209,
-0.15291832387447357,
-0.035561416298151016,
0.012948171235620975,
-0.19471494853496552,
-0.029087699949741364,
0.0628380998969078,
0.12108335644006729,
-0.18625959753990173,
0.007091721054166555,
0.1487557590007782,
0.003495437791571021,
0.2763431668281555,
-0.41404134035110474,
-0.00862063281238079,
0.27081239223480225,
-0.03656155988574028,
-0.5318862199783325,
0.07630077749490738,
-0.01967567205429077,
0.03722815960645676,
0.14742928743362427,
0.20877724885940552,
-0.09174821525812149,
0.2286226749420166,
0.1620422601699829,
0.10821432620286942,
0.07512926310300827,
0.29078394174575806,
-0.04542376101016998,
-0.2973693907260895,
0.018083741888403893,
-0.18563304841518402,
-0.0844445452094078,
-0.09447230398654938,
0.07018852233886719,
-0.20027317106723785,
0.01745563931763172,
-0.011113297194242477,
0.02420671284198761,
-0.1290869563817978,
0.1871158480644226,
-0.11391685903072357,
0.17917662858963013,
0.06843303889036179,
-0.262410968542099,
0.2238655686378479,
-0.27189576625823975,
-0.009047172032296658,
-0.17587299644947052,
-0.0690755620598793,
-0.0018049009377136827,
0.11335689574480057,
0.03900529071688652,
-0.054678767919540405,
-0.0558667816221714,
0.06406310945749283,
-0.13548687100410461,
-0.2624402642250061,
-0.16788946092128754,
-0.05672946944832802,
-0.3315863609313965,
-0.06088043749332428,
-0.15535968542099,
0.03751817345619202,
-0.23795810341835022,
0.186649352312088,
-0.11708441376686096,
0.07368333637714386,
-0.08631915599107742,
-0.28967589139938354,
-0.1878817230463028,
0.30471786856651306,
-0.1621740460395813,
-0.23076705634593964,
-0.31585729122161865,
0.004292855970561504,
0.013102876953780651,
0.04436379671096802,
-0.0857064500451088,
-0.05838041380047798,
0.024160342290997505,
0.20135679841041565,
0.13419611752033234,
0.1824069768190384,
-0.08068493753671646,
0.1530042439699173,
0.11450918763875961,
0.2670186758041382,
-0.4843783974647522,
-0.1912359893321991,
0.09101522713899612,
0.07147656381130219,
0.1891709715127945,
0.022929567843675613,
-0.20013204216957092,
0.042097896337509155,
-0.0886927917599678,
-0.0499824620783329,
-0.02284587360918522,
-0.13688050210475922,
-0.2118801325559616,
-0.01700332574546337,
-0.09405719488859177,
-0.3251819908618927,
-0.12690575420856476,
0.3295981287956238,
0.2071095108985901,
-0.05164920538663864,
-0.3561212420463562,
-0.11284411698579788,
0.22384701669216156,
-0.03241512551903725,
0.10691297054290771,
-0.0812641978263855,
-0.07487064599990845,
0.10527360439300537,
0.006521223578602076,
0.10880600661039352,
0.27898257970809937,
-0.07979776710271835,
0.13630299270153046,
-0.049297165125608444,
-0.11870711296796799,
0.13324815034866333,
0.059051234275102615,
0.2542007267475128,
-0.09426548331975937,
-0.10832025855779648,
0.089971624314785,
0.15322884917259216,
-0.06177588924765587,
-0.13774678111076355,
-0.044539935886859894,
0.11936432123184204,
0.186482772231102,
0.17406828701496124,
0.08943604677915573,
0.2547815442085266,
-0.18711073696613312,
-0.02178388647735119,
0.012147661298513412,
0.09484872221946716,
0.023608772084116936,
0.3262484669685364,
-0.10462110489606857,
-0.09763643145561218,
-0.17562726140022278,
-0.03527522087097168,
-0.12863953411579132,
-0.15765321254730225,
0.0814405083656311,
-0.0876878872513771,
0.148832306265831,
0.30207332968711853,
-0.12865705788135529,
0.012536358088254929,
0.10621029138565063,
0.23488746583461761,
-0.31029513478279114,
-0.0010180436074733734,
0.15766069293022156,
0.11805061250925064,
-0.09784232825040817,
0.22480803728103638,
-0.020947003737092018,
0.19967207312583923,
0.021979158744215965,
-0.08648712188005447,
0.04141411930322647,
-0.16170190274715424,
0.3327476382255554,
-0.05347532406449318,
-0.1626107394695282,
-0.06952793896198273,
0.11495719105005264,
-0.34294381737709045,
0.0007287647458724678,
-0.2734467387199402,
-0.24027873575687408,
0.17907871305942535,
0.22363097965717316,
0.007001153193414211,
0.03166181594133377,
-0.04311681538820267,
-0.14684495329856873,
-0.09749279916286469,
-0.18114247918128967,
-0.04798711836338043,
0.02442682348191738,
-0.104750856757164,
-0.3804093599319458,
0.04811478033661842,
0.14145109057426453,
0.02167784981429577,
-0.1802619844675064,
-0.013706043362617493,
0.12115797400474548,
-0.12161502987146378,
-0.04634013772010803,
-0.23177482187747955,
-0.13087517023086548,
0.13907483220100403,
0.13762101531028748,
-0.059577759355306625,
0.004557856824249029,
0.037020549178123474,
-0.06087813153862953,
0.17168061435222626,
-0.13275277614593506,
0.11860822886228561,
-0.11972051858901978,
-0.19045715034008026,
-0.266873300075531,
-0.028729448094964027,
0.0578312985599041,
0.23085276782512665,
0.0794667974114418,
0.09607906639575958,
-0.040621571242809296,
-0.11989676207304001,
-0.11445443332195282,
0.22689926624298096,
0.3025972545146942,
-0.3463636636734009,
-0.07656838744878769,
0.14729195833206177,
-0.04876700043678284,
0.13170123100280762,
0.2736026346683502,
0.18690961599349976,
0.028857536613941193,
0.14521127939224243,
-0.2123984396457672,
0.055513523519039154,
-0.025287874042987823,
0.17316631972789764,
0.31303679943084717,
0.006505143363028765,
0.1958300620317459,
0.043730538338422775,
0.1691894382238388,
0.250900000333786,
-0.017581410706043243,
0.12191165238618851,
-0.0031297877430915833,
-0.25112801790237427,
0.025599606335163116,
-0.08080924302339554,
-0.183163583278656,
-0.06503060460090637,
0.012457786127924919,
0.11756303906440735,
0.11563976109027863,
0.019242890179157257,
-0.16404733061790466,
-0.04085160791873932,
-0.12196771800518036,
0.06257190555334091,
-0.3033806383609772,
0.05872859060764313,
0.14657674729824066,
-0.06514009833335876,
0.016126859933137894,
0.06095973774790764,
0.05955571308732033,
-0.07304359972476959,
0.02411423623561859,
0.17692263424396515,
0.0553944893181324,
0.13614141941070557,
-0.171585351228714,
-0.06440272927284241,
-0.10831110924482346,
-0.18698668479919434,
0.18057340383529663,
-0.03675473481416702,
-0.12783372402191162,
-0.1074601337313652,
-0.019898727536201477,
0.12574775516986847,
0.23714739084243774,
0.01688775233924389,
0.048802755773067474,
0.12644238770008087,
0.11336173117160797,
-0.10563220828771591,
-0.02855021506547928,
0.16023501753807068,
0.024589667096734047,
0.21837343275547028,
0.09810864925384521,
0.014083603397011757,
0.003490122500807047,
-0.2129961997270584,
-0.20170320570468903,
-0.17783939838409424,
0.15875829756259918,
-0.07238997519016266,
-0.14667853713035583,
0.012227186933159828,
-0.12580707669258118,
0.003626578487455845,
0.11857130378484726,
-0.05713474377989769,
-0.017277531325817108,
0.1683005392551422,
-0.0949672982096672,
0.22671465575695038,
-0.11946473270654678,
-0.20100891590118408,
-0.15713882446289062,
-0.1644471138715744,
-0.0796545222401619,
-0.1336345672607422,
-0.02695455774664879,
-0.24676309525966644,
0.17953871190547943,
-0.138405442237854,
-0.15731042623519897,
0.11122354120016098,
-0.12382913380861282,
0.08984506875276566,
0.39412158727645874,
0.11158880591392517,
0.13574272394180298,
-0.14174474775791168,
0.11605320870876312,
0.469866007566452,
-0.1275385171175003,
-0.3840077221393585,
0.05102652311325073,
0.09408668428659439,
0.055422961711883545,
-0.05387697368860245,
-0.09777344763278961,
-0.19839328527450562,
-0.14867672324180603,
-0.12190107256174088,
-0.1262291967868805,
-0.08719547837972641,
0.04573288559913635,
-0.24054798483848572,
0.0562715008854866,
0.11655416339635849,
0.15424567461013794,
-0.02122865617275238,
-0.04004812240600586,
-0.11004216969013214,
0.08048190176486969,
-0.2873626947402954,
0.1373658925294876,
0.1552194356918335,
0.11890605837106705,
-0.2305671125650406,
0.138192817568779,
0.10257043689489365,
0.26460543274879456,
-0.05638137832283974,
0.11536943912506104,
-0.010836050845682621,
0.16492724418640137,
0.10844855010509491,
-0.0034309576731175184,
-0.11217829585075378,
0.03189031407237053,
-0.07486739754676819,
-0.014995375648140907,
-0.03156641125679016,
0.16536162793636322,
-0.06476566940546036,
0.020727386698126793,
-0.12945376336574554,
0.2877614200115204,
-0.14817354083061218,
-0.11647620052099228,
-0.012750452384352684,
0.04261378198862076,
0.19352233409881592,
-0.0725867748260498,
0.1639033555984497,
0.17151878774166107,
0.23830845952033997,
0.10809418559074402,
-0.1049947440624237,
-0.1061902567744255,
-0.24823664128780365,
0.07856481522321701,
-0.03124881722033024,
-0.16663740575313568,
-0.14838390052318573,
-0.06664954870939255,
-0.08617676794528961,
-0.14150471985340118,
-0.15777981281280518,
-0.2702620327472687,
-0.022769000381231308,
-0.2505263388156891,
0.1863071620464325,
-0.06598810106515884,
0.0820210874080658,
0.013535796664655209,
-0.027087341994047165,
-0.000006592589670617599,
-0.10973357409238815,
0.028374936431646347,
0.029418962076306343,
0.2230205535888672,
-0.06737466901540756,
-0.3724912405014038,
0.08046592772006989,
-0.22698192298412323,
-0.6228405833244324,
0.07868198305368423,
-0.010260545648634434,
0.07748729735612869,
-0.06037679687142372,
0.1590338945388794,
-0.1776607483625412,
0.3033407926559448,
0.1715197116136551,
0.08772367238998413,
-0.031023310497403145,
0.27031460404396057,
0.14519190788269043,
-0.018915273249149323,
-0.14934642612934113,
0.009485408663749695,
0.07050608098506927,
0.1525687575340271,
-0.22556143999099731,
-0.054318126291036606,
-0.35950157046318054,
-0.11909257620573044,
0.14092203974723816,
0.22825829684734344,
0.3924349844455719,
0.08301866054534912,
-0.1745709627866745,
-0.09461099654436111,
0.05698008090257645,
0.2697429955005646,
-0.4024152457714081,
-0.0626835823059082,
-0.04461469501256943,
0.32392674684524536,
0.29580673575401306,
0.1728394776582718,
-0.14144514501094818,
0.19442594051361084,
-0.028053274378180504,
0.25034990906715393,
-0.007751554250717163,
0.15316732227802277,
-0.06481264531612396,
0.5492362380027771,
0.1214294359087944,
0.1928481161594391,
-0.19143794476985931,
-0.12227944284677505,
0.13456249237060547,
-0.019760485738515854,
-0.25692540407180786,
0.1071443259716034,
-0.16768500208854675,
-0.14575707912445068,
0.16695570945739746,
0.11793991923332214,
-0.07691455632448196,
-0.1248723566532135,
0.10173682123422623,
0.1583397090435028,
0.31179338693618774,
-0.05809760093688965,
0.13367995619773865,
-0.4157145321369171,
0.27560293674468994,
-0.33423781394958496,
0.07299765199422836,
-0.14236396551132202,
0.27289649844169617,
-0.09807679057121277,
-0.3890940248966217,
-0.14238408207893372,
-0.1694534868001938,
0.2775307297706604,
-0.16002222895622253,
-0.37526535987854004,
0.2719247043132782,
0.45613548159599304,
-0.07962442189455032,
-0.04129614681005478,
-0.14259177446365356,
0.258833646774292,
0.11400101333856583,
0.0860193744301796,
0.18675187230110168,
0.07457317411899567,
0.05198013409972191,
-0.07544714957475662,
0.2084960639476776,
0.08997001498937607,
-0.017796272411942482,
-0.036839574575424194,
-0.09025608748197556,
-0.2274080067873001,
0.09682026505470276,
-0.12816230952739716,
-0.1181407943367958,
-0.08705388009548187,
-0.04794183745980263,
-0.06052412837743759,
0.10050857812166214,
-0.11910635977983475,
0.48160409927368164,
0.01778312586247921,
-0.2983452081680298,
-0.08675439655780792,
-0.09703847765922546,
0.13821792602539062,
0.15144436061382294,
0.00920075923204422,
0.04899483174085617,
0.0579792857170105,
-0.193381667137146,
0.1447649598121643,
0.06067477539181709,
0.15149833261966705,
0.30862298607826233,
-0.17646996676921844,
-0.12097230553627014,
0.2802501916885376,
-0.27300137281417847,
-0.278697669506073,
-0.09212947636842728,
-0.17064638435840607,
0.1675277203321457,
-0.008381490595638752,
0.34168654680252075,
-0.22317391633987427,
-0.07533995062112808,
0.12120522558689117,
-0.13244083523750305,
-0.1394495815038681,
-0.08866873383522034,
-0.08159071207046509,
-0.18150457739830017,
-0.03075089305639267,
0.14234457910060883,
-0.042222924530506134,
0.11821188032627106,
-0.00891964789479971,
0.13281388580799103,
-0.09128191322088242,
-0.46963319182395935,
0.09187912195920944,
0.16386555135250092,
-0.14969654381275177,
-0.06699640303850174,
-0.06168781593441963,
0.18531160056591034,
0.06963648647069931,
0.21792659163475037,
0.0017647382337599993,
-0.06873150169849396,
-0.2259971797466278,
-0.19571129977703094,
-0.21948349475860596,
0.11494600027799606,
-0.18372796475887299,
-0.2304144948720932,
0.03107060119509697,
-0.1317157745361328,
-0.1085013896226883,
-0.19120900332927704,
-0.026266958564519882,
0.058035437017679214,
0.06701289117336273,
0.029887689277529716,
0.02986058220267296,
0.10184173285961151,
0.07788083702325821,
-0.08736031502485275,
-0.04530169069766998,
-0.024745263159275055,
-0.049965206533670425,
0.06050872057676315,
0.1373775750398636,
0.056366924196481705,
0.12039323896169662,
-0.05464234948158264,
-0.15182556211948395,
0.025781985372304916,
-0.06520877033472061,
0.05608389526605606,
-0.3453228771686554,
-0.04129786044359207,
0.07283961772918701,
0.11407306045293808,
-0.22649703919887543,
0.1767982840538025,
0.15827329456806183,
0.034266792237758636
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. .The age of PA diagnosis, frequency of metabolic decompensation, and residual enzymatic activity do not correlate with presence/absence of cardiomyopathy in individuals with PA .Rarely, cardiomyopathy can occur as an apparently isolated clinical phenomenon in previously healthy individuals without documented episodes of metabolic decompensation or neurocognitive deficits .Cardiomyopathy can progress to cardiac failure and may be associated with sudden death .Cardiac rhythm abnormalities. A prolonged QT interval is often detected in individuals with PA . This can be associated with syncope, arrhythmia, and cardiac arrest .Gastrointestinal manifestationsPancreatitis (reported in 3%-18% of individuals) may be recurrent and may present with anorexia, recurrent nausea, and abdominal pain . In some individuals recurrent pancreatitis can lead to insulin-dependent diabetes.Poor feeding and lack of appetite are common, affecting up to 76% of affected individuals .Emesis and diarrhea are commonly reported in individuals with PA, becoming a recurrent problem in approximately 6% .Liver issues include hepatomegaly, hypoalbuminemia, and | [
0.07209199666976929,
0.17597247660160065,
-0.10820791870355606,
-0.12023191154003143,
0.0810585469007492,
-0.014629215002059937,
-0.004180651158094406,
-0.09261676669120789,
-0.07198154181241989,
-0.26374655961990356,
0.06239764392375946,
0.015848258510231972,
-0.07394290715456009,
0.09189008176326752,
-0.338565856218338,
0.10485062748193741,
0.05877828225493431,
0.19996123015880585,
-0.09698352217674255,
-0.07518193125724792,
-0.1531933695077896,
-0.19470348954200745,
0.09558314830064774,
0.003514292184263468,
0.2240050882101059,
-0.24860134720802307,
0.04949265718460083,
-0.2912912964820862,
0.2512078583240509,
0.12775059044361115,
0.005676185712218285,
0.06540050357580185,
0.1238880604505539,
-0.26949891448020935,
0.1774391084909439,
-0.11923882365226746,
-0.0552307665348053,
-0.28164607286453247,
0.04308969900012016,
-0.24586798250675201,
-0.12943661212921143,
-0.13592778146266937,
0.21264290809631348,
-0.1269609034061432,
0.31424447894096375,
-0.1789444535970688,
0.004772488493472338,
-0.07259589433670044,
-0.23974038660526276,
0.005359209142625332,
0.19204320013523102,
-0.17552606761455536,
-0.1311439424753189,
0.152207151055336,
0.06933026760816574,
-0.10700976103544235,
-0.1422956883907318,
0.20214998722076416,
-0.05325644463300705,
0.21564026176929474,
0.03501972183585167,
-0.1496097594499588,
-0.17840133607387543,
-0.4902490973472595,
0.08605322986841202,
0.02707183174788952,
0.025371236726641655,
0.1430637389421463,
0.2508662939071655,
-0.023585503920912743,
0.22969494760036469,
0.012491637840867043,
0.08522765338420868,
0.12960976362228394,
0.005180052947252989,
-0.005507070571184158,
0.1714334785938263,
0.005958916619420052,
0.043243758380413055,
-0.29637420177459717,
-0.2048906683921814,
-0.05370180308818817,
-0.03421410545706749,
-0.22698764503002167,
-0.013344567269086838,
0.21521726250648499,
0.20796436071395874,
-0.0699438825249672,
-0.12150123715400696,
0.14703679084777832,
0.23085181415081024,
-0.18161334097385406,
-0.20301930606365204,
-0.03714706748723984,
-0.12415387481451035,
0.10261601209640503,
0.15703733265399933,
0.002315897960215807,
-0.1330326497554779,
0.021011054515838623,
-0.05848349258303642,
-0.19635042548179626,
-0.08877602964639664,
0.09025240689516068,
-0.08629433065652847,
0.2026849389076233,
-0.2189818024635315,
0.0732012689113617,
-0.07569731771945953,
0.197363018989563,
0.29854780435562134,
-0.11348836123943329,
0.10618451982736588,
-0.23075491189956665,
-0.44662073254585266,
0.2217283695936203,
-0.0781761035323143,
0.22279080748558044,
0.09461674094200134,
-0.11316613107919693,
0.10606326162815094,
0.12040705978870392,
0.010682559572160244,
0.08170630782842636,
0.15993082523345947,
0.09911105036735535,
-0.011324267834424973,
-0.1040450930595398,
0.22904711961746216,
0.0802406370639801,
0.05237991362810135,
-0.012749657966196537,
0.050470981746912,
-0.20685341954231262,
0.14063461124897003,
0.022855613380670547,
-0.333685040473938,
-0.3491191267967224,
-0.21600043773651123,
-0.09456855058670044,
0.06885221600532532,
0.0366339348256588,
0.16835583746433258,
0.14663319289684296,
0.08637554943561554,
0.0939791351556778,
0.4569852650165558,
0.013704990968108177,
0.12732940912246704,
0.007529358379542828,
-0.11393634974956512,
-0.16989648342132568,
0.13454653322696686,
-0.12705503404140472,
-0.18340623378753662,
0.2190166413784027,
0.08384943753480911,
0.20971526205539703,
-0.28052443265914917,
0.08667873591184616,
0.0014132520882412791,
-0.11196278035640717,
-0.09685580432415009,
-0.0753624364733696,
-0.08520740270614624,
-0.04561632126569748,
-0.22395171225070953,
-0.017076419666409492,
-0.13660314679145813,
-0.16409635543823242,
-0.06856057792901993,
-0.018901720643043518,
0.15006642043590546,
0.003270757384598255,
-0.04298200458288193,
0.14170975983142853,
0.017365792766213417,
-0.01580323465168476,
-0.1694706678390503,
0.09654033929109573,
0.2370287925004959,
0.10117986798286438,
-0.5838363170623779,
0.02826838195323944,
-0.02635236456990242,
-0.19479843974113464,
0.06648305803537369,
0.20820088684558868,
0.06024128943681717,
0.13977724313735962,
0.08994554728269577,
0.14733760058879852,
0.07483004033565521,
0.249972864985466,
-0.143479585647583,
-0.2757813334465027,
-0.013531242497265339,
-0.127767413854599,
-0.12974870204925537,
0.005658378824591637,
-0.02020152285695076,
-0.31432923674583435,
0.08853496611118317,
0.024428319185972214,
0.11048746854066849,
-0.07509288936853409,
0.2792208194732666,
0.0030117020942270756,
0.0290987528860569,
0.08401813358068466,
-0.25815752148628235,
0.4016787111759186,
-0.2615600526332855,
-0.1672239750623703,
-0.24669981002807617,
0.020777160301804543,
-0.1084321141242981,
-0.02521664649248123,
-0.013525942340493202,
-0.20477604866027832,
0.11871729046106339,
0.03531981259584427,
-0.014706665650010109,
-0.17859885096549988,
-0.11502903699874878,
0.08970392495393753,
-0.23997947573661804,
-0.0016558464849367738,
-0.08936873823404312,
-0.0868636816740036,
-0.21538618206977844,
0.21774595975875854,
-0.04485922306776047,
0.17426814138889313,
0.01203901506960392,
-0.3581944704055786,
-0.08310024440288544,
0.2940175235271454,
-0.03611340373754501,
-0.2556966543197632,
-0.4757958650588989,
-0.04004625603556633,
0.0991368219256401,
0.15744321048259735,
-0.033302851021289825,
-0.07395273447036743,
0.09280187636613846,
0.26469188928604126,
0.08851711452007294,
0.02362658455967903,
-0.051580749452114105,
0.19545285403728485,
0.06701740622520447,
0.15201511979103088,
-0.45190081000328064,
-0.019488561898469925,
0.09056445956230164,
-0.1413193792104721,
0.21906545758247375,
0.05335788056254387,
-0.2053423374891281,
0.07839643210172653,
0.029041312634944916,
-0.009008861146867275,
0.1208614632487297,
-0.02558361552655697,
-0.1608932465314865,
-0.009248205460608006,
-0.00766204996034503,
-0.16985134780406952,
0.11134204268455505,
0.25805702805519104,
0.19324898719787598,
-0.061406418681144714,
-0.3660215437412262,
-0.1266145259141922,
0.09443242102861404,
-0.14233839511871338,
0.12327878922224045,
0.012081381864845753,
-0.12495775520801544,
0.09279779344797134,
0.14190788567066193,
0.07129637151956558,
0.12771987915039062,
-0.12641207873821259,
0.19051678478717804,
-0.03968651592731476,
-0.1309971958398819,
0.06600185483694077,
-0.05177746340632439,
0.1972975730895996,
-0.11756259948015213,
0.13401345908641815,
-0.10758194327354431,
0.09890090674161911,
-0.1165458932518959,
-0.21557170152664185,
-0.04434920474886894,
0.12160012871026993,
0.08898042887449265,
0.1303708404302597,
0.15914706885814667,
0.16037532687187195,
-0.06055791676044464,
0.03313838317990303,
0.08079764991998672,
0.011303850449621677,
0.11300680041313171,
0.301710307598114,
-0.0035298215225338936,
-0.14639796316623688,
-0.14019078016281128,
-0.06139368191361427,
-0.13788199424743652,
-0.11658822745084763,
0.09863736480474472,
0.20281082391738892,
0.24092450737953186,
0.19237947463989258,
-0.0016582953976467252,
0.008061828091740608,
0.15101702511310577,
0.21914595365524292,
-0.359100878238678,
0.06201772019267082,
0.008620212785899639,
0.09426221251487732,
-0.06769261509180069,
0.18270601332187653,
-0.16322320699691772,
0.174404576420784,
0.08258343487977982,
-0.10819150507450104,
0.07646641880273819,
-0.22467850148677826,
0.40461966395378113,
0.05528256669640541,
-0.11706527322530746,
0.04919859766960144,
0.14441676437854767,
-0.3123348355293274,
0.005264517851173878,
-0.2984079122543335,
-0.1920466125011444,
0.18736632168293,
0.01521106157451868,
0.2072935551404953,
0.022740617394447327,
-0.07366105169057846,
-0.1884448379278183,
0.052081603556871414,
-0.2175978422164917,
-0.11663063615560532,
0.07172873616218567,
-0.07937834411859512,
-0.32460811734199524,
0.0501587875187397,
0.3082237243652344,
0.09086427092552185,
-0.22884206473827362,
-0.07603538036346436,
0.17751750349998474,
-0.09533463418483734,
-0.11089998483657837,
-0.09730835258960724,
-0.10769063234329224,
0.09807487577199936,
0.08926095068454742,
-0.06364196538925171,
0.01303032599389553,
0.10732543468475342,
-0.05017523467540741,
0.18736232817173004,
-0.1495812088251114,
0.20737257599830627,
-0.1086995080113411,
0.026211198419332504,
-0.4184200167655945,
0.040450628846883774,
-0.0029620681889355183,
0.027936048805713654,
0.06188909709453583,
0.19029103219509125,
0.11840106546878815,
0.035717304795980453,
-0.0970752090215683,
0.34764915704727173,
0.1536545753479004,
-0.49957433342933655,
-0.026132836937904358,
0.15574857592582703,
0.1543082296848297,
0.09411684423685074,
0.11693179607391357,
0.3044182360172272,
0.1668291836977005,
0.32519063353538513,
-0.1543281227350235,
0.11521879583597183,
0.09778950363397598,
0.1970430165529251,
0.3419865071773529,
0.021693645045161247,
0.25927600264549255,
-0.016510726884007454,
-0.01563454419374466,
0.24885119497776031,
-0.008562820963561535,
0.001077332184650004,
0.01814979314804077,
-0.2934568226337433,
0.16532178223133087,
-0.06956006586551666,
-0.2440781444311142,
-0.07576175779104233,
-0.17817242443561554,
0.08097707480192184,
0.18240240216255188,
0.2328519970178604,
-0.14870283007621765,
-0.030515966936945915,
0.027966905385255814,
0.0661952793598175,
-0.3226650059223175,
0.1707943081855774,
0.14160437881946564,
-0.10128805786371231,
-0.0011853661853820086,
0.005720909219235182,
0.13935935497283936,
-0.03334975615143776,
0.17390775680541992,
0.10394692420959473,
0.2635921835899353,
0.003631070489063859,
-0.11205364763736725,
-0.02054852619767189,
0.06607089936733246,
-0.16634148359298706,
0.16384539008140564,
-0.08208487927913666,
-0.23133325576782227,
-0.08489871025085449,
-0.11891251057386398,
0.1554764360189438,
0.1731908768415451,
0.04621727019548416,
0.12096655368804932,
0.038546960800886154,
0.12199611961841583,
-0.11961520463228226,
0.14742206037044525,
0.011419967748224735,
0.05612000823020935,
0.1758773773908615,
0.15460307896137238,
-0.10512323677539825,
-0.04897519201040268,
-0.007871857844293118,
-0.2644788324832916,
-0.22127513587474823,
0.018359607085585594,
-0.08437170833349228,
-0.09390012174844742,
0.2296849638223648,
-0.14389316737651825,
0.17085687816143036,
0.1299099624156952,
0.031221244484186172,
0.1745343953371048,
0.15415441989898682,
-0.11333002150058746,
0.23305068910121918,
-0.13823360204696655,
-0.22219330072402954,
0.03097626008093357,
-0.18113753199577332,
-0.2914893329143524,
0.0783013328909874,
-0.068425752222538,
-0.18505504727363586,
0.09969603270292282,
-0.04492027312517166,
-0.2389790415763855,
0.23090510070323944,
-0.1432826668024063,
0.08508248627185822,
0.262562096118927,
0.25457513332366943,
0.04201921820640564,
-0.0643424391746521,
0.11160144954919815,
0.49954721331596375,
-0.044854432344436646,
-0.3171488046646118,
0.04890932887792587,
-0.1561194211244583,
-0.10055316984653473,
0.025477377697825432,
-0.16405044496059418,
-0.11847434937953949,
-0.03502482548356056,
-0.16547763347625732,
-0.031201982870697975,
-0.16299226880073547,
-0.1136871725320816,
-0.046835027635097504,
0.16604046523571014,
0.16371241211891174,
0.07673247903585434,
0.1779976189136505,
-0.05027037486433983,
-0.02573048323392868,
0.1439765840768814,
-0.247358500957489,
0.11135482043027878,
0.2999378740787506,
0.22275817394256592,
-0.1883534938097,
0.08987836539745331,
0.11867459863424301,
0.24859894812107086,
-0.04016144573688507,
0.08423527330160141,
-0.06471628695726395,
0.1660488098859787,
0.1939069926738739,
-0.10357917845249176,
-0.11172197759151459,
0.203654482960701,
-0.21783775091171265,
-0.06549011915922165,
0.0358157679438591,
0.10753379762172699,
-0.09494170546531677,
-0.16767585277557373,
-0.1319866180419922,
0.08292961120605469,
-0.0031855152919888496,
-0.1060076430439949,
0.16892102360725403,
-0.018968842923641205,
0.09126126021146774,
-0.09472141414880753,
0.19570794701576233,
0.15541888773441315,
0.11798470467329025,
0.187954843044281,
-0.05278346315026283,
0.05698104202747345,
-0.13267993927001953,
0.03038042038679123,
-0.02813410572707653,
-0.1043703705072403,
-0.007062113378196955,
-0.16629767417907715,
-0.08682365715503693,
-0.18189013004302979,
-0.1186530813574791,
-0.2195741981267929,
-0.025739440694451332,
-0.10330156236886978,
0.16827267408370972,
-0.05941063538193703,
0.15907415747642517,
0.06409445405006409,
-0.045461516827344894,
-0.06230709329247475,
-0.05645090341567993,
-0.03115886263549328,
0.060309503227472305,
0.06902985274791718,
0.005505234934389591,
-0.24050244688987732,
-0.0010090996511280537,
-0.14144039154052734,
-0.6108379364013672,
0.0622018538415432,
-0.008780046366155148,
0.022715263068675995,
-0.036104362457990646,
0.15283769369125366,
-0.16752205789089203,
0.1995915025472641,
0.05850926414132118,
0.01012185774743557,
0.11351680010557175,
0.1966373324394226,
0.06499797105789185,
-0.1911492645740509,
-0.1345469206571579,
-0.02661273069679737,
-0.06983363628387451,
0.22823423147201538,
0.00007655824447283521,
0.3081739842891693,
-0.3450138568878174,
-0.11360271275043488,
0.012630986049771309,
0.13592609763145447,
0.18257896602153778,
0.0812302678823471,
-0.09569605439901352,
-0.08975895494222641,
-0.10480717569589615,
0.14215904474258423,
-0.22610460221767426,
-0.10903740674257278,
-0.15717816352844238,
0.28521376848220825,
0.32347026467323303,
0.2310963124036789,
-0.14231981337070465,
-0.011347570456564426,
-0.12237673997879028,
0.10860563069581985,
-0.13826821744441986,
-0.030370360240340233,
-0.14114978909492493,
0.29821985960006714,
0.14186163246631622,
0.30460548400878906,
-0.1596415787935257,
-0.30536073446273804,
0.10837454348802567,
-0.03249463066458702,
-0.13056057691574097,
0.07447560876607895,
-0.0672503113746643,
-0.06184567138552666,
0.3702022135257721,
0.018471291288733482,
-0.1378335803747177,
-0.1346418857574463,
-0.013711763545870781,
0.055695682764053345,
0.3689560890197754,
-0.12587878108024597,
0.17526809871196747,
-0.2695615589618683,
0.21189196407794952,
-0.083048976957798,
0.0906711220741272,
-0.07790441066026688,
0.2132231593132019,
-0.1347278207540512,
-0.3538859188556671,
-0.08788462728261948,
-0.25971779227256775,
0.18616852164268494,
-0.09565169364213943,
-0.13606050610542297,
0.2518868148326874,
0.22378626465797424,
-0.23097635805606842,
-0.047417473047971725,
-0.19550977647304535,
0.2566622793674469,
0.015471133403480053,
0.06549271196126938,
0.10394356399774551,
0.04567869007587433,
0.059174321591854095,
-0.22258898615837097,
0.06858199834823608,
0.29212531447410583,
-0.08963017165660858,
-0.04075711593031883,
-0.2550554871559143,
-0.04810967668890953,
0.20545674860477448,
-0.004176991060376167,
-0.017569050192832947,
-0.027688559144735336,
0.04639242962002754,
-0.08404691517353058,
0.12895771861076355,
-0.2338016778230667,
0.23927465081214905,
-0.023590216413140297,
-0.4430634081363678,
-0.03496294841170311,
-0.151563361287117,
0.16289786994457245,
0.00433342345058918,
-0.023052917793393135,
-0.04739009216427803,
-0.0230364128947258,
-0.39870312809944153,
0.1475692093372345,
0.011751262471079826,
0.27413615584373474,
0.21915103495121002,
-0.08602643013000488,
-0.11836013942956924,
0.3385072648525238,
-0.26692506670951843,
-0.3247573673725128,
-0.12058117240667343,
-0.15885710716247559,
-0.05228642746806145,
-0.10669450461864471,
0.2905646562576294,
-0.08600090444087982,
-0.06913522630929947,
-0.0021364865824580193,
-0.22706282138824463,
-0.09548473358154297,
0.06565901637077332,
-0.17197254300117493,
-0.1223585233092308,
-0.13041020929813385,
0.2345198392868042,
-0.14001354575157166,
0.25613686442375183,
-0.12595073878765106,
0.1269807666540146,
-0.13140840828418732,
-0.34866365790367126,
0.11601504683494568,
-0.042842622846364975,
-0.19636686146259308,
-0.06985995918512344,
-0.09641725569963455,
0.2263619601726532,
0.07350096106529236,
0.27183419466018677,
0.07941846549510956,
-0.2838532030582428,
-0.4336187541484833,
-0.25824543833732605,
-0.26651129126548767,
0.126416876912117,
-0.17825116217136383,
-0.13790257275104523,
0.007630283944308758,
0.0007321504526771605,
-0.05581352859735489,
-0.08907689899206161,
-0.04697408154606819,
0.11081606894731522,
-0.1259727030992508,
0.0032987170852720737,
-0.07837889343500137,
0.10757460445165634,
0.10321293026208878,
-0.24643363058567047,
-0.1270345002412796,
-0.029932348057627678,
0.03317537158727646,
0.04201304167509079,
0.08785855025053024,
0.22456616163253784,
0.21596889197826385,
0.02625352516770363,
-0.2919765114784241,
-0.23018614947795868,
-0.0346236452460289,
0.1257886290550232,
-0.18775179982185364,
0.006102506536990404,
0.061717353761196136,
0.14376796782016754,
-0.29043278098106384,
0.30938589572906494,
0.10478940606117249,
0.15421554446220398
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. and cardiac arrest .Gastrointestinal manifestationsPancreatitis (reported in 3%-18% of individuals) may be recurrent and may present with anorexia, recurrent nausea, and abdominal pain . In some individuals recurrent pancreatitis can lead to insulin-dependent diabetes.Poor feeding and lack of appetite are common, affecting up to 76% of affected individuals .Emesis and diarrhea are commonly reported in individuals with PA, becoming a recurrent problem in approximately 6% .Liver issues include hepatomegaly, hypoalbuminemia, and abnormal liver function tests (ALT, AST, GGT, INR, and bilirubin) . The etiology of hepatic dysfunction has not been determined with certainty but may include the inherent metabolic derangement as well as cardiac dysfunction in individuals with cardiomyopathy.Renal abnormalities have been infrequently documented and are likely underreported. Examples have included impaired renal function , chronic renal insufficiency leading to renal transplant at age 42 years , and progressive kidney disease in the third decade of life .Hematologic abnormalities. Although anemia, | [
-0.008358169347047806,
0.16137103736400604,
-0.00449828477576375,
-0.056647930294275284,
0.0718608871102333,
0.01868216134607792,
0.05038624256849289,
-0.15982097387313843,
-0.06146392971277237,
-0.1559491604566574,
0.1579771786928177,
-0.006490887142717838,
-0.0004609707393683493,
-0.05727642402052879,
-0.31304359436035156,
0.12314321845769882,
-0.03822141885757446,
0.09083814918994904,
-0.2524702548980713,
-0.028778180480003357,
-0.14030276238918304,
-0.11994068324565887,
-0.010899019427597523,
0.06512727588415146,
0.30904918909072876,
-0.3119466006755829,
-0.018575752153992653,
-0.2301362156867981,
0.22144325077533722,
0.15996049344539642,
0.08870986849069595,
0.04434751346707344,
0.1614675372838974,
-0.12963248789310455,
0.03430074453353882,
-0.14561529457569122,
-0.04614785313606262,
-0.42629143595695496,
0.08234396576881409,
-0.27445098757743835,
0.04139169305562973,
-0.19991108775138855,
0.1815880686044693,
-0.11948920041322708,
0.2797723710536957,
-0.2035289853811264,
-0.06381009519100189,
-0.06834467500448227,
-0.060207147151231766,
0.26269054412841797,
0.15093150734901428,
-0.09516341239213943,
-0.08700839430093765,
0.033583711832761765,
-0.028664959594607353,
-0.2063313126564026,
-0.04319000244140625,
0.08981990069150925,
-0.1655789017677307,
0.1944219470024109,
0.0284002423286438,
-0.16268175840377808,
-0.1445537805557251,
-0.4173106849193573,
0.07341105490922928,
-0.03370467200875282,
-0.06290369480848312,
0.0480765774846077,
0.20385731756687164,
-0.16075263917446136,
0.153647318482399,
-0.0459858663380146,
-0.016654381528496742,
0.14096325635910034,
0.10461995750665665,
0.017175812274217606,
0.16324715316295624,
0.11736360937356949,
0.12846152484416962,
-0.4503571093082428,
-0.3141964077949524,
-0.1507669985294342,
-0.014407460577785969,
-0.17646339535713196,
-0.08288788795471191,
0.1419413834810257,
0.2683313488960266,
-0.028755148872733116,
-0.02411762997508049,
0.19188711047172546,
0.13876968622207642,
-0.1927618682384491,
-0.22619014978408813,
-0.04439511150121689,
-0.0783899798989296,
0.005110165569931269,
0.17497871816158295,
-0.1262475550174713,
-0.22884085774421692,
-0.0916643738746643,
0.02155604399740696,
-0.08418001234531403,
-0.039026618003845215,
0.10383488237857819,
-0.09308934956789017,
0.04995299130678177,
-0.12295182049274445,
0.018968086689710617,
0.06336809694766998,
0.1857682764530182,
0.33007729053497314,
-0.23742707073688507,
0.10664340108633041,
-0.15020813047885895,
-0.5131815075874329,
-0.018950825557112694,
-0.17012298107147217,
0.15538176894187927,
0.03422712907195091,
-0.19229140877723694,
0.03269082307815552,
0.12000563740730286,
-0.00003478676808299497,
0.1950913667678833,
0.1425362527370453,
-0.0007910397252999246,
-0.07929717749357224,
-0.09483266621828079,
0.15200895071029663,
0.05355653539299965,
0.09506963193416595,
-0.0392480231821537,
0.05125528201460838,
-0.3020106256008148,
0.12805524468421936,
0.09609699994325638,
-0.4132024049758911,
-0.441632479429245,
-0.1282002329826355,
-0.09404022991657257,
0.06685540080070496,
0.07603935152292252,
0.2831566035747528,
0.20027856528759003,
0.22314506769180298,
0.07566184550523758,
0.3311886787414551,
-0.07572878897190094,
-0.019356494769454002,
0.013539699837565422,
-0.13546274602413177,
-0.18477307260036469,
0.17457444965839386,
-0.09067124128341675,
-0.29542213678359985,
0.26781535148620605,
0.13049975037574768,
0.2947520911693573,
-0.24035118520259857,
0.08165309578180313,
0.004148584324866533,
-0.17524804174900055,
-0.0310664065182209,
-0.17158690094947815,
-0.11451637744903564,
-0.10182178020477295,
-0.20646940171718597,
-0.009184809401631355,
-0.08395449072122574,
0.011024095118045807,
0.11416621506214142,
-0.0869808942079544,
0.11785625666379929,
0.1047716736793518,
0.07900461554527283,
-0.047300178557634354,
0.06603303551673889,
-0.12158380448818207,
-0.007698883768171072,
0.23631437122821808,
0.21980029344558716,
0.010961812920868397,
-0.47071602940559387,
-0.031397078186273575,
-0.11573117226362228,
-0.25768929719924927,
-0.03335599973797798,
0.20590204000473022,
0.0716094970703125,
0.20171771943569183,
0.01069505512714386,
0.14819246530532837,
0.07352571189403534,
0.16129298508167267,
-0.116822749376297,
-0.2796741724014282,
0.050914544612169266,
-0.04807932674884796,
-0.13669730722904205,
-0.014382208697497845,
-0.08618646115064621,
-0.2830374240875244,
0.2020437866449356,
0.10308202356100082,
-0.10843844711780548,
0.061104387044906616,
0.15834647417068481,
0.026317348703742027,
0.06192408502101898,
0.014569244347512722,
-0.0939759761095047,
0.3141722083091736,
-0.22692076861858368,
-0.1782078742980957,
-0.10312911123037338,
-0.008470239117741585,
-0.21856072545051575,
-0.168587788939476,
0.0657055601477623,
-0.025582291185855865,
-0.018482355400919914,
0.059228576719760895,
0.04123639315366745,
-0.28768017888069153,
-0.12168322503566742,
0.18835675716400146,
-0.14868859946727753,
-0.02875552698969841,
-0.08280067890882492,
-0.2031392604112625,
-0.205788254737854,
0.2610208988189697,
0.016910452395677567,
0.19177228212356567,
-0.04602480307221413,
-0.19643741846084595,
-0.1292727291584015,
0.291098952293396,
-0.14423547685146332,
-0.21561293303966522,
-0.40647444128990173,
-0.04809001833200455,
0.16372886300086975,
-0.04463167116045952,
-0.012741473503410816,
-0.053631026297807693,
0.047003887593746185,
0.3227245807647705,
0.06213540583848953,
0.023330101743340492,
0.06445979326963425,
0.23383574187755585,
0.12510807812213898,
0.012708630412817001,
-0.3778687119483948,
0.13654285669326782,
-0.009301766753196716,
-0.10139010101556778,
0.13731686770915985,
0.006259902846068144,
-0.16513453423976898,
0.07344773411750793,
0.05051065981388092,
0.16452224552631378,
0.10136532783508301,
0.07589509338140488,
-0.1061561182141304,
0.11123266071081161,
0.03351869061589241,
-0.007853000424802303,
0.06015372648835182,
0.23338623344898224,
0.19921264052391052,
0.029877427965402603,
-0.3734121024608612,
-0.08486934006214142,
0.048837803304195404,
-0.08314581215381622,
0.13915713131427765,
-0.02100284956395626,
-0.053969692438840866,
0.0733935534954071,
0.09705931693315506,
0.12550196051597595,
0.25415316224098206,
0.00904008001089096,
0.11495690792798996,
0.03062116727232933,
-0.03300091624259949,
0.05072830244898796,
0.08240724354982376,
0.16436803340911865,
-0.10166768729686737,
0.11374615132808685,
0.038063909858465195,
0.18775781989097595,
-0.13259588181972504,
-0.11721175909042358,
0.004275904037058353,
0.1872459053993225,
0.014977898448705673,
0.07710664719343185,
0.22654013335704803,
0.01552574336528778,
-0.06094134971499443,
0.041471853852272034,
0.04763420671224594,
-0.0028056504670530558,
0.11257827281951904,
0.3845236897468567,
0.02507861889898777,
-0.20196521282196045,
-0.058921292424201965,
-0.11883819103240967,
-0.11491045355796814,
0.03676421940326691,
0.21184028685092926,
0.2732073664665222,
0.29672205448150635,
0.17525537312030792,
-0.036130763590335846,
0.08383835852146149,
0.16134826838970184,
0.16352978348731995,
-0.34116214513778687,
0.0025546173565089703,
-0.07685387879610062,
-0.07430046051740646,
0.0009412592044100165,
0.1066335067152977,
-0.2130267471075058,
0.14724858105182648,
0.13917289674282074,
-0.17593492567539215,
0.14205394685268402,
-0.2582078278064728,
0.4374294877052307,
0.10766981542110443,
-0.10249932110309601,
0.0597650445997715,
0.16071699559688568,
-0.286558598279953,
0.059272948652505875,
-0.36605674028396606,
-0.1762053221464157,
0.22098931670188904,
0.01280607283115387,
0.2515469193458557,
-0.01250429730862379,
-0.058482445776462555,
-0.24920974671840668,
0.14818374812602997,
-0.2970019578933716,
-0.11980868875980377,
0.19735625386238098,
-0.0487944595515728,
-0.1364709436893463,
0.13019119203090668,
0.5056331157684326,
0.13277390599250793,
-0.28753265738487244,
-0.030132828280329704,
0.18133282661437988,
-0.12330583482980728,
0.08762766420841217,
-0.26669982075691223,
-0.04675156623125076,
-0.013972217217087746,
0.04377273470163345,
-0.020100804045796394,
-0.03964817151427269,
0.2248392105102539,
0.04139085114002228,
0.1791439652442932,
-0.21591992676258087,
0.2839418649673462,
-0.1015825942158699,
0.13394184410572052,
-0.32445114850997925,
-0.0006986227817833424,
-0.036508843302726746,
0.04705911874771118,
0.09997145086526871,
0.012298300862312317,
0.18974731862545013,
0.07319509238004684,
-0.12901988625526428,
0.2993585765361786,
0.08668015897274017,
-0.5493037104606628,
0.06378444284200668,
0.2059355527162552,
0.05499441549181938,
0.16691429913043976,
0.12348397076129913,
0.17585015296936035,
0.10056900978088379,
0.3076319098472595,
-0.22439350187778473,
0.10729754716157913,
0.12291461229324341,
0.14462725818157196,
0.2973875403404236,
0.02817254699766636,
0.22751960158348083,
0.025157850235700607,
0.08903743326663971,
0.10090475529432297,
-0.10035821795463562,
0.018809128552675247,
0.027997873723506927,
-0.31261834502220154,
0.050568778067827225,
-0.06104545667767525,
-0.16406813263893127,
-0.17516466975212097,
-0.15163971483707428,
0.07312101870775223,
0.2822018563747406,
0.13659615814685822,
-0.11563891172409058,
-0.14684492349624634,
-0.0392860509455204,
0.010422022081911564,
-0.3153579831123352,
0.2563241422176361,
0.08677583932876587,
-0.04189619421958923,
-0.02077876776456833,
0.1225135400891304,
0.15645533800125122,
-0.07945431768894196,
0.1673153042793274,
0.0045058042742311954,
0.260855108499527,
0.00627778610214591,
-0.13166749477386475,
-0.12273108959197998,
0.10378743708133698,
-0.17823269963264465,
0.1498051881790161,
-0.1093674972653389,
-0.16549745202064514,
-0.08859782665967941,
-0.1360950618982315,
0.35333651304244995,
0.2316814661026001,
0.21782588958740234,
-0.021329466253519058,
-0.024940289556980133,
0.17679165303707123,
-0.05364125221967697,
0.0520186610519886,
0.02474309876561165,
0.21484117209911346,
0.07542628794908524,
0.22168488800525665,
-0.14605596661567688,
-0.10405417531728745,
0.09819614142179489,
-0.27330878376960754,
-0.061968058347702026,
0.10637428611516953,
-0.1527296006679535,
-0.12179458141326904,
0.18636804819107056,
-0.23578253388404846,
0.10903766006231308,
0.05585569888353348,
0.17621220648288727,
0.27451831102371216,
0.13284291326999664,
0.02592669241130352,
0.1101670190691948,
-0.1743997186422348,
-0.35756614804267883,
0.024779709056019783,
-0.19053100049495697,
-0.17739377915859222,
0.09396380186080933,
-0.013417541980743408,
-0.11979641765356064,
0.03742637857794762,
0.0318317711353302,
-0.19660133123397827,
0.29116296768188477,
-0.20235197246074677,
0.12927770614624023,
0.3108849823474884,
0.11841423809528351,
-0.02915153279900551,
-0.04450671002268791,
0.09335155040025711,
0.43209874629974365,
-0.04299117997288704,
-0.3242402970790863,
0.08959539979696274,
-0.0839824303984642,
-0.17415200173854828,
0.1859879344701767,
-0.1502532809972763,
-0.0986543521285057,
-0.24925164878368378,
-0.21956531703472137,
-0.03970098868012428,
-0.10348709672689438,
-0.024477699771523476,
0.019425207749009132,
-0.006891525350511074,
0.2009890228509903,
0.0058481935411691666,
0.09255124628543854,
-0.027474042028188705,
-0.12531061470508575,
0.14886805415153503,
-0.33932000398635864,
0.16020655632019043,
0.2580336332321167,
0.15230126678943634,
-0.22138014435768127,
0.21361766755580902,
0.21213234961032867,
0.26305341720581055,
-0.0026327678933739662,
-0.05803389847278595,
-0.07132535427808762,
0.10107340663671494,
0.2901366055011749,
-0.13612543046474457,
-0.16675350069999695,
0.19071921706199646,
-0.2425895780324936,
-0.21678273379802704,
0.07650098204612732,
0.20608294010162354,
-0.10032055526971817,
-0.17173703014850616,
0.06589418649673462,
0.033946335315704346,
-0.0037505580112338066,
-0.06936568021774292,
0.16440148651599884,
-0.01732293702661991,
-0.005297414492815733,
-0.286565899848938,
0.2416938692331314,
0.14390556514263153,
0.1470479816198349,
0.1545991748571396,
0.02165159210562706,
0.08648257702589035,
-0.17562605440616608,
-0.059524670243263245,
-0.030820904299616814,
-0.09306677430868149,
-0.06267126649618149,
-0.16459423303604126,
-0.09104254841804504,
-0.2794368863105774,
0.0011955287773162127,
-0.28850114345550537,
-0.11769289523363113,
-0.11554481089115143,
0.10481199622154236,
-0.04718230292201042,
0.1468440294265747,
0.0510619692504406,
-0.06636787950992584,
-0.14153535664081573,
0.06545794755220413,
-0.02052208036184311,
0.15625372529029846,
0.18451164662837982,
0.043741222470998764,
-0.24480785429477692,
0.19698718190193176,
-0.15890976786613464,
-0.4572206437587738,
-0.06290476024150848,
0.11916779726743698,
0.17314830422401428,
-0.18004348874092102,
0.15048468112945557,
-0.1720401644706726,
0.09141911566257477,
-0.03032882884144783,
0.015617712400853634,
0.08056984841823578,
0.24107025563716888,
0.07192660868167877,
-0.2706530690193176,
-0.2147643268108368,
0.05268165096640587,
0.001164862303994596,
0.2590169310569763,
-0.07153641432523727,
0.41408205032348633,
-0.22363361716270447,
-0.0964108556509018,
-0.026706628501415253,
0.251315712928772,
0.1886855810880661,
-0.02850346826016903,
-0.08856181800365448,
-0.1825607419013977,
-0.12100961059331894,
0.09683594852685928,
-0.11910045892000198,
-0.06253878772258759,
-0.12890705466270447,
0.3657456338405609,
0.20634983479976654,
0.27447986602783203,
-0.08085359632968903,
-0.0971313863992691,
-0.026026958599686623,
0.1815599948167801,
-0.0583704449236393,
0.06574631482362747,
-0.1338169276714325,
0.12898477911949158,
-0.03140141814947128,
0.2287692278623581,
-0.005316672381013632,
-0.3162606656551361,
0.19510400295257568,
-0.026752717792987823,
-0.10806896537542343,
-0.03556687384843826,
-0.10439883172512054,
0.1221272200345993,
0.3770483732223511,
0.15170209109783173,
-0.13840773701667786,
-0.13429442048072815,
-0.09740345925092697,
-0.025221090763807297,
0.3831922113895416,
-0.18885314464569092,
0.21371716260910034,
-0.18081702291965485,
0.1449771225452423,
0.05107594653964043,
0.08800073713064194,
-0.12072844803333282,
0.19729731976985931,
-0.07978060841560364,
-0.2709149718284607,
-0.012465088628232479,
-0.26129600405693054,
0.12701675295829773,
-0.03156307339668274,
-0.05601857602596283,
0.14420104026794434,
0.2091124802827835,
-0.15803726017475128,
-0.00008359491039300337,
-0.19000521302223206,
0.18153400719165802,
-0.008420479483902454,
0.08056631684303284,
0.09960158169269562,
0.05858058109879494,
0.050986140966415405,
-0.2375364750623703,
-0.06635072827339172,
0.27441665530204773,
-0.07663517445325851,
0.03470682352781296,
-0.3277619183063507,
-0.035920605063438416,
0.1173328310251236,
-0.012406038120388985,
-0.022847013548016548,
-0.06369537115097046,
0.05804811418056488,
0.03532511368393898,
0.1505335122346878,
-0.19682849943637848,
0.39363059401512146,
-0.06324761360883713,
-0.3966843783855438,
-0.0000155419074872043,
0.03933905065059662,
0.14118699729442596,
0.10336383432149887,
-0.06427895277738571,
-0.15266861021518707,
0.12014805525541306,
-0.4485118091106415,
0.06609462946653366,
-0.04200945049524307,
0.122780941426754,
0.20991863310337067,
-0.04115399345755577,
-0.006629633251577616,
0.43848028779029846,
-0.20588895678520203,
-0.3631751835346222,
0.017255939543247223,
-0.15075385570526123,
-0.16711123287677765,
-0.043289974331855774,
0.2449609637260437,
-0.01513831876218319,
-0.14303429424762726,
0.024778177961707115,
-0.2717593014240265,
-0.04767055809497833,
-0.05367886275053024,
-0.1517113596200943,
-0.2550860345363617,
-0.26146167516708374,
0.20986013114452362,
-0.05760836601257324,
0.07305865734815598,
-0.14480207860469818,
0.15013918280601501,
-0.2004285603761673,
-0.1713704913854599,
0.04368498921394348,
0.03506435453891754,
-0.163251593708992,
-0.059237346053123474,
-0.0005941525450907648,
0.14356158673763275,
-0.04642336070537567,
0.1638031303882599,
0.08807457983493805,
-0.24588234722614288,
-0.4039498567581177,
-0.21263886988162994,
-0.32117608189582825,
0.15669983625411987,
-0.10250897705554962,
-0.021677039563655853,
0.07821502536535263,
0.012883632443845272,
-0.09836646169424057,
-0.004365020431578159,
-0.10213854163885117,
0.26964154839515686,
-0.08556674420833588,
-0.0015934472903609276,
0.05769863724708557,
0.09704069793224335,
-0.05757366865873337,
-0.18424229323863983,
-0.25607335567474365,
-0.10179251432418823,
0.08084272593259811,
0.17703638970851898,
-0.09762046486139297,
0.19884470105171204,
0.1286076456308365,
0.1999729424715042,
-0.23473986983299255,
-0.11664240807294846,
-0.03615333139896393,
0.07988176494836807,
-0.03741167113184929,
-0.08370772749185562,
0.0019007151713594794,
0.06471090018749237,
-0.21792346239089966,
0.38307085633277893,
0.028372274711728096,
0.09339731931686401
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , hypoalbuminemia, and abnormal liver function tests (ALT, AST, GGT, INR, and bilirubin) . The etiology of hepatic dysfunction has not been determined with certainty but may include the inherent metabolic derangement as well as cardiac dysfunction in individuals with cardiomyopathy.Renal abnormalities have been infrequently documented and are likely underreported. Examples have included impaired renal function , chronic renal insufficiency leading to renal transplant at age 42 years , and progressive kidney disease in the third decade of life .Hematologic abnormalities. Although anemia, leukopenia, and thrombocytopenia are common, pancytopenia is seen less frequently, in 6%-15% of individuals . Myelodysplastic changes in the bone marrow are uncommon .Immune system. Early retrospective data suggested high frequency of recurrent infections seen in 60%-80% of affected individuals . Factors predisposing to infectious complications were likely diverse and included bone marrow suppression, immune dysfunction instigated by propionic acid metabolites, indwelling catheters (e.g., central lines), frequent hospitalizations | [
0.11725016683340073,
0.03129170835018158,
0.004914242774248123,
-0.20209959149360657,
-0.0011952526401728392,
0.027119776234030724,
0.12896865606307983,
-0.1229805126786232,
-0.12509168684482574,
-0.043967105448246,
0.14297382533550262,
0.014685142785310745,
0.08678655326366425,
-0.02358732372522354,
-0.19435736536979675,
0.14119863510131836,
-0.036341387778520584,
0.010028528049588203,
-0.09814711660146713,
-0.12606923282146454,
-0.0016492793802171946,
-0.14186784625053406,
-0.16637252271175385,
0.1059592068195343,
0.199494406580925,
-0.25989770889282227,
0.17578090727329254,
-0.209369957447052,
0.12794336676597595,
-0.009417994879186153,
0.02086956985294819,
-0.08482580631971359,
0.023963239043951035,
-0.1190948635339737,
-0.002170374384149909,
-0.13861176371574402,
-0.18821580708026886,
-0.25953570008277893,
0.15375518798828125,
-0.296511173248291,
0.03946691006422043,
-0.1704159528017044,
0.10506216436624527,
-0.041871048510074615,
-0.03584887832403183,
0.024404266849160194,
-0.12767350673675537,
0.023363882675766945,
0.14092406630516052,
0.3039871156215668,
0.016624033451080322,
-0.08510434627532959,
-0.13942036032676697,
-0.06743895262479782,
0.0688251405954361,
-0.3136169910430908,
-0.0950542762875557,
0.030180269852280617,
-0.042916540056467056,
0.1454656720161438,
0.17519187927246094,
-0.13212043046951294,
-0.1717018038034439,
-0.20968320965766907,
0.11679988354444504,
-0.1810809224843979,
-0.09789343923330307,
0.20435969531536102,
0.13636507093906403,
-0.09978090971708298,
0.34898504614830017,
-0.13310107588768005,
-0.11599688977003098,
0.1127382293343544,
0.019756337627768517,
0.062034349888563156,
0.09996932744979858,
-0.09362176060676575,
0.07603960484266281,
-0.31193792819976807,
-0.26810717582702637,
0.023270687088370323,
-0.05176983401179314,
-0.21717706322669983,
-0.1028348058462143,
0.16902904212474823,
0.14054779708385468,
0.010722723789513111,
0.006871524266898632,
0.13593541085720062,
0.06780517846345901,
0.0686367079615593,
-0.2826712131500244,
0.08505082875490189,
0.15539370477199554,
0.004512072540819645,
0.12802593410015106,
-0.0379662960767746,
-0.10309617221355438,
0.09514957666397095,
0.004993386100977659,
0.12446965277194977,
-0.08766430616378784,
0.03761785477399826,
-0.0013136001070961356,
-0.12797130644321442,
-0.10069207847118378,
0.09882134944200516,
-0.10810225456953049,
0.13976767659187317,
0.24399405717849731,
-0.12040525674819946,
0.06704194843769073,
0.025415560230612755,
-0.4492730498313904,
-0.17300903797149658,
-0.0978713259100914,
0.19349059462547302,
0.17810161411762238,
-0.18266087770462036,
0.0278485044836998,
0.10229990631341934,
-0.057332247495651245,
0.10308414697647095,
0.28413131833076477,
-0.05336031690239906,
-0.07856543362140656,
-0.1008058562874794,
0.1841745376586914,
0.09552484005689621,
0.13497135043144226,
-0.10175547748804092,
0.16279847919940948,
-0.3281480371952057,
0.13466955721378326,
-0.07342614978551865,
-0.20254546403884888,
-0.4074685275554657,
-0.0699828490614891,
0.18145164847373962,
0.028547998517751694,
0.247318297624588,
0.27835971117019653,
0.2230335921049118,
0.2173628807067871,
0.03679104149341583,
0.2689310610294342,
0.0654020607471466,
0.15269678831100464,
0.1399119347333908,
-0.0598631352186203,
-0.2733387053012848,
0.08746806532144547,
-0.03837912529706955,
-0.24674448370933533,
0.11641576886177063,
-0.059218212962150574,
0.2690512537956238,
-0.17739929258823395,
-0.12803204357624054,
-0.05655556172132492,
-0.16386978328227997,
0.19141116738319397,
-0.1458650827407837,
-0.07131479680538177,
-0.0742371454834938,
-0.18227916955947876,
0.08296947926282883,
0.02807561494410038,
-0.018424872308969498,
0.046292372047901154,
-0.04111877456307411,
0.08759292215108871,
-0.023044785484671593,
0.30722519755363464,
0.04937394708395004,
0.049868810921907425,
-0.20411445200443268,
-0.14655758440494537,
0.1748594492673874,
0.044953394681215286,
-0.14990392327308655,
-0.4957329332828522,
-0.1968744993209839,
-0.02828974835574627,
-0.2208484560251236,
0.1580764353275299,
0.20783977210521698,
0.08357588946819305,
0.2571585178375244,
0.27186572551727295,
0.056429482996463776,
0.05907250568270683,
-0.05752386152744293,
-0.03199554979801178,
-0.16227500140666962,
-0.03343120962381363,
0.03787105903029442,
-0.11325028538703918,
0.04301561415195465,
0.06608910113573074,
-0.21713092923164368,
0.1717209815979004,
-0.175315260887146,
-0.07399751991033554,
-0.033627767115831375,
0.08784697204828262,
0.08518969267606735,
0.32561925053596497,
0.07889669388532639,
-0.12020540237426758,
0.09484639018774033,
-0.18651773035526276,
-0.10694150626659393,
-0.2373521476984024,
-0.067681223154068,
-0.0787774845957756,
-0.23249761760234833,
0.021193191409111023,
0.2069050520658493,
0.007651458494365215,
0.08221445232629776,
-0.06446333974599838,
-0.24656181037425995,
-0.17385976016521454,
-0.03238757699728012,
-0.27566367387771606,
-0.16097457706928253,
0.050727590918540955,
-0.03969898447394371,
-0.18180282413959503,
0.16804495453834534,
-0.011185367591679096,
0.16345015168190002,
-0.1559375822544098,
-0.10145365446805954,
-0.28729212284088135,
0.22613051533699036,
-0.16491155326366425,
-0.099124014377594,
-0.4971525967121124,
0.1169331967830658,
0.11975790560245514,
-0.14975140988826752,
-0.09606138616800308,
0.1389523297548294,
-0.03495103865861893,
0.2281884104013443,
-0.08861573040485382,
0.1703409105539322,
0.06683501601219177,
0.01889924518764019,
0.009710934944450855,
-0.004679964389652014,
-0.28779545426368713,
-0.11879568547010422,
0.04498409479856491,
-0.09010308235883713,
-0.0381220206618309,
-0.19328543543815613,
-0.021129755303263664,
0.047222815454006195,
0.18387775123119354,
0.019552165642380714,
-0.019646447151899338,
-0.08059759438037872,
-0.1871785819530487,
0.09772355854511261,
0.0961228758096695,
-0.19050060212612152,
-0.10576458275318146,
0.09311718493700027,
0.1204143762588501,
-0.01837531290948391,
-0.15295735001564026,
0.018285704776644707,
-0.00995839573442936,
-0.03306785598397255,
0.16020196676254272,
0.05489188805222511,
-0.017595011740922928,
0.26259028911590576,
0.06063348054885864,
0.18322162330150604,
0.10885877162218094,
0.13658985495567322,
-0.032103847712278366,
0.018337449058890343,
0.01771785318851471,
0.014590710401535034,
0.04143786057829857,
0.20182429254055023,
0.09168501198291779,
-0.0648408904671669,
0.1007879301905632,
0.16498315334320068,
-0.1843310445547104,
-0.09356766194105148,
-0.1218956708908081,
0.04088467359542847,
0.05551287159323692,
0.20937971770763397,
0.1449103057384491,
0.042751625180244446,
-0.23129193484783173,
-0.02461029589176178,
0.11000952124595642,
0.11217276751995087,
0.09900461137294769,
0.25639763474464417,
-0.10693197697401047,
-0.1204766109585762,
0.01849847286939621,
-0.04741352051496506,
-0.028760617598891258,
0.02094891667366028,
0.0097148222848773,
0.034656111150979996,
0.3066602051258087,
0.2785087823867798,
-0.05366462841629982,
-0.06152571365237236,
0.1439293473958969,
0.22017621994018555,
-0.1263056993484497,
-0.015207167714834213,
-0.015567582100629807,
-0.06808480620384216,
-0.12425007671117783,
0.057157911360263824,
-0.05999698489904404,
0.11331862211227417,
0.16131852567195892,
-0.09257322549819946,
0.08710041642189026,
-0.2212386578321457,
0.1342567652463913,
0.028601553291082382,
-0.06572973728179932,
0.011942560784518719,
0.04655599594116211,
-0.38916608691215515,
0.09744925051927567,
-0.35228583216667175,
-0.27883556485176086,
0.12670862674713135,
0.18227419257164001,
0.19253835082054138,
0.09127787500619888,
-0.024072906002402306,
-0.10561451315879822,
-0.10614608973264694,
-0.13594327867031097,
-0.16696825623512268,
0.15027467906475067,
-0.04249531775712967,
-0.21123908460140228,
0.1555732637643814,
0.2600312829017639,
0.08563283830881119,
-0.2902214527130127,
0.1441534459590912,
0.034176379442214966,
-0.17530035972595215,
0.12564928829669952,
-0.1525503396987915,
-0.12323975563049316,
0.09177171438932419,
0.08841078728437424,
-0.1163916066288948,
0.14064480364322662,
0.24314455687999725,
0.015067671425640583,
-0.054727278649806976,
-0.12917593121528625,
0.21154451370239258,
-0.036871422082185745,
-0.05754277855157852,
-0.2741829454898834,
-0.07094478607177734,
-0.03060525842010975,
0.13832427561283112,
0.1700686514377594,
-0.06669577211141586,
0.169710174202919,
0.2269446700811386,
-0.1853582113981247,
0.011758334003388882,
0.12778055667877197,
-0.282012939453125,
-0.03633081540465355,
0.19564373791217804,
-0.03204081952571869,
0.17586298286914825,
-0.008856145665049553,
0.06962434202432632,
-0.015304148197174072,
0.09476114064455032,
-0.15798120200634003,
0.008241206407546997,
0.028001833707094193,
0.08853738009929657,
0.36440959572792053,
0.13106749951839447,
0.19989638030529022,
0.10593098402023315,
0.10024985671043396,
0.017868822440505028,
-0.2515990436077118,
0.12786807119846344,
-0.02623576670885086,
-0.18464910984039307,
-0.026535948738455772,
-0.20836740732192993,
-0.12907052040100098,
-0.10241497308015823,
-0.15298908948898315,
-0.023350784555077553,
0.23578733205795288,
-0.1147027462720871,
-0.1297954022884369,
-0.11876308917999268,
0.031230958178639412,
-0.027859579771757126,
-0.28027188777923584,
0.21904368698596954,
0.03696535527706146,
-0.016276147216558456,
0.022024326026439667,
0.12778882682323456,
0.15265904366970062,
0.07462303340435028,
0.030836910009384155,
0.1887224018573761,
0.281566858291626,
0.08425645530223846,
-0.26217588782310486,
-0.07189895957708359,
-0.03028138168156147,
-0.20755483210086823,
0.14567089080810547,
0.0362854078412056,
-0.15025439858436584,
-0.0038212998770177364,
0.008152826689183712,
0.24056284129619598,
0.09472353756427765,
0.17417709529399872,
-0.062042128294706345,
-0.07463905215263367,
0.2653990089893341,
-0.0601993091404438,
0.048904020339250565,
0.032168637961149216,
0.13009624183177948,
0.1085970476269722,
0.12845931947231293,
-0.2437577098608017,
-0.008794096298515797,
0.045064572244882584,
-0.2668823301792145,
0.04649093747138977,
0.2658195495605469,
-0.010989573784172535,
-0.11707291752099991,
0.22302062809467316,
-0.32574424147605896,
0.005452212877571583,
0.02754533849656582,
0.16381573677062988,
0.13132262229919434,
0.07340273261070251,
-0.032646358013153076,
0.11560409516096115,
-0.09655791521072388,
-0.17371879518032074,
0.05388174206018448,
0.10567640513181686,
-0.11380802094936371,
0.26182401180267334,
0.018961630761623383,
-0.05931863933801651,
0.047081053256988525,
0.054245591163635254,
0.005260777194052935,
0.11681249737739563,
-0.29189857840538025,
0.13812163472175598,
0.36293739080429077,
-0.017932279035449028,
0.125654399394989,
-0.10679858922958374,
0.08904791623353958,
0.3397635817527771,
-0.14270968735218048,
-0.06875044852495193,
-0.06818263977766037,
-0.1609749048948288,
-0.052647996693849564,
0.09917687624692917,
-0.027978504076600075,
-0.12013138830661774,
-0.20171096920967102,
-0.08854754269123077,
-0.04603197053074837,
0.05584421381354332,
0.12953223288059235,
-0.1242276132106781,
-0.13481275737285614,
0.18009783327579498,
0.055298782885074615,
0.07322265207767487,
0.00614384887740016,
-0.12131910026073456,
0.05328436940908432,
-0.174483984708786,
0.2293095588684082,
0.16989734768867493,
0.03508060425519943,
-0.22954268753528595,
0.154047891497612,
0.18196648359298706,
0.22739958763122559,
0.19168749451637268,
-0.10489948093891144,
-0.02820131927728653,
0.13280178606510162,
0.23240739107131958,
-0.182334765791893,
-0.11937123537063599,
-0.02609163708984852,
-0.23533733189105988,
-0.17905449867248535,
0.1883973777294159,
0.2943425178527832,
-0.00551569415256381,
-0.0604386180639267,
-0.03886628895998001,
-0.011645207181572914,
0.007386429235339165,
0.012197364121675491,
0.15414085984230042,
-0.11549069732427597,
0.16288389265537262,
-0.3181491792201996,
0.16224507987499237,
0.2612970769405365,
0.18675772845745087,
0.09570883959531784,
0.1070663183927536,
0.16377222537994385,
-0.19806382060050964,
-0.033455267548561096,
-0.08182118833065033,
-0.006090169306844473,
-0.1575586497783661,
-0.021905578672885895,
-0.21115797758102417,
-0.12047260254621506,
0.04552346467971802,
-0.09726903587579727,
-0.12104182690382004,
-0.11517105996608734,
-0.013357972726225853,
0.18848614394664764,
0.05812154710292816,
0.13988129794597626,
-0.10323967784643173,
-0.1357334852218628,
0.025019720196723938,
-0.09042581915855408,
0.1226784735918045,
0.16831614077091217,
-0.009063972160220146,
-0.12198279798030853,
0.22836384177207947,
-0.12057588994503021,
-0.24037030339241028,
0.036303043365478516,
0.014472458511590958,
-0.011284977197647095,
-0.09344349801540375,
0.20737187564373016,
-0.08473560214042664,
0.11952032893896103,
-0.012457473203539848,
-0.12568430602550507,
0.19050173461437225,
0.36164548993110657,
0.10454535484313965,
-0.06414291262626648,
-0.23391123116016388,
0.21987536549568176,
0.0007974372711032629,
0.06665749847888947,
-0.09161978960037231,
0.20454208552837372,
-0.10215168446302414,
-0.03699522465467453,
0.07403556257486343,
0.25367259979248047,
0.3784284293651581,
0.09739036858081818,
-0.21220463514328003,
-0.13915207982063293,
0.020939966663718224,
0.09519613534212112,
-0.185069739818573,
0.120485320687294,
-0.0028141532093286514,
0.16477863490581512,
0.12759257853031158,
0.2535156011581421,
0.09970293194055557,
-0.051270902156829834,
-0.023908033967018127,
0.0836993157863617,
-0.12788020074367523,
0.20435675978660583,
-0.11186429113149643,
0.2531934380531311,
0.11955631524324417,
0.15774746239185333,
0.04305390268564224,
-0.19038976728916168,
0.24311529099941254,
-0.2521820366382599,
-0.09257383644580841,
-0.11339104920625687,
-0.16979791224002838,
0.09170888364315033,
0.23582391440868378,
0.027877777814865112,
0.000813429185654968,
-0.1377517431974411,
0.012939229607582092,
-0.08795983344316483,
0.13956542313098907,
-0.08940105885267258,
0.0059223477728664875,
-0.1591772586107254,
0.04331077262759209,
-0.13203556835651398,
0.05998050421476364,
-0.10054319351911545,
0.19436904788017273,
-0.02450583688914776,
-0.10026662796735764,
-0.10803598910570145,
-0.15714380145072937,
0.11342725157737732,
0.0528351292014122,
-0.047289732843637466,
0.042285893112421036,
0.3353615999221802,
-0.05347849428653717,
0.06575573235750198,
-0.07283367216587067,
0.18824976682662964,
-0.05284581333398819,
0.07029474526643753,
0.014167415909469128,
0.025325531139969826,
0.04030656814575195,
-0.20600757002830505,
0.10689517855644226,
0.07494988292455673,
-0.10891599208116531,
-0.07226978242397308,
-0.07054964452981949,
-0.17001973092556,
0.1151275560259819,
-0.20430336892604828,
0.00015456246910616755,
0.042665671557188034,
0.08885657787322998,
0.08197653293609619,
0.1061081737279892,
-0.17416951060295105,
0.34447038173675537,
-0.1129688024520874,
-0.30574503540992737,
-0.22304585576057434,
-0.027381760999560356,
0.2035679817199707,
0.27387747168540955,
0.06694759428501129,
-0.02428189292550087,
0.25485163927078247,
-0.2583880126476288,
0.0876164510846138,
-0.05913171172142029,
0.11077746003866196,
0.17364628612995148,
-0.07386832684278488,
-0.14514945447444916,
0.40410634875297546,
-0.08824381232261658,
-0.40118592977523804,
-0.051784515380859375,
-0.1389816254377365,
0.10759472101926804,
-0.07476961612701416,
0.0826103612780571,
-0.08105742186307907,
-0.1496185064315796,
0.14940263330936432,
-0.17381536960601807,
0.07608893513679504,
-0.16697701811790466,
-0.23043595254421234,
-0.2958150804042816,
-0.13697490096092224,
0.2927839756011963,
0.0253832396119833,
0.17008696496486664,
-0.169010728597641,
0.16698336601257324,
-0.26605743169784546,
-0.3085109293460846,
0.019628191366791725,
0.1619865894317627,
-0.0653243362903595,
0.02137361653149128,
-0.07626762241125107,
-0.061158303171396255,
-0.04724421352148056,
0.2661030888557434,
-0.011851616203784943,
0.017645418643951416,
-0.15576289594173431,
-0.17092877626419067,
-0.17735664546489716,
0.11313486844301224,
-0.2380451112985611,
-0.058232177048921585,
0.13352133333683014,
-0.08111652731895447,
-0.07283606380224228,
0.015277491882443428,
-0.22024035453796387,
0.2118334174156189,
0.16715635359287262,
0.05082688480615616,
0.05613967031240463,
0.20540450513362885,
-0.20688635110855103,
-0.0387037992477417,
-0.06318128854036331,
-0.29925110936164856,
0.07979478687047958,
0.16354700922966003,
0.009440668858587742,
-0.03673896566033363,
0.01281120628118515,
0.0771450623869896,
-0.264362633228302,
-0.18548168241977692,
-0.04340028762817383,
-0.02902650274336338,
-0.09718126058578491,
-0.0597132183611393,
0.05704130232334137,
0.12914064526557922,
-0.12872929871082306,
0.11233995854854584,
0.055003710091114044,
0.02116428129374981
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. Hematologic abnormalities. Although anemia, leukopenia, and thrombocytopenia are common, pancytopenia is seen less frequently, in 6%-15% of individuals . Myelodysplastic changes in the bone marrow are uncommon .Immune system. Early retrospective data suggested high frequency of recurrent infections seen in 60%-80% of affected individuals . Factors predisposing to infectious complications were likely diverse and included bone marrow suppression, immune dysfunction instigated by propionic acid metabolites, indwelling catheters (e.g., central lines), frequent hospitalizations, and potential nutritional deficiencies caused by dietary modification. Although staphylococcal scalded skin syndrome and Candida skin infections were reported in the earlier literature , more recent natural history studies suggest that such complications are uncommon .Hypogammaglobulinemia, B-cell lymphopenia, decreased CD4 and CD8 counts, and abnormal CD4/CD8 ratio have been described . Hypogammaglobulinemia, reported in as many as 15% of affected individuals, has required treatment with immunoglobulin in some cases .Ophthalmologic | [
0.11939520388841629,
0.015680808573961258,
-0.022766923531889915,
-0.15043385326862335,
-0.044949766248464584,
0.02958017960190773,
0.17091907560825348,
-0.09720487147569656,
-0.1817014366388321,
-0.06116141006350517,
0.07566521316766739,
-0.07158318907022476,
0.07473091036081314,
-0.03772224485874176,
-0.3011404275894165,
0.1433553248643875,
0.013554232195019722,
0.10958204418420792,
-0.07521501928567886,
-0.04867646470665932,
0.03346136584877968,
-0.11547102779150009,
0.01433208305388689,
0.14173392951488495,
0.21811464428901672,
-0.23811860382556915,
0.16015157103538513,
-0.15276245772838593,
0.09480664134025574,
-0.032322417944669724,
0.06061698496341705,
-0.009972000494599342,
-0.05019371584057808,
-0.15090562403202057,
0.07235480844974518,
-0.11369957029819489,
-0.1233038529753685,
-0.3600929379463196,
0.1163460910320282,
-0.38185185194015503,
0.05939001217484474,
-0.14269672334194183,
-0.08697604387998581,
0.06074225530028343,
-0.004497641231864691,
0.03463377058506012,
-0.05893811956048012,
0.11940664798021317,
-0.041121892631053925,
0.124925397336483,
0.07639379054307938,
-0.14819346368312836,
-0.08512750267982483,
-0.017396435141563416,
-0.01899760775268078,
-0.2699480652809143,
-0.182907372713089,
0.057435352355241776,
-0.03740981966257095,
-0.026284227147698402,
0.15167124569416046,
-0.1946602612733841,
-0.09156327694654465,
-0.2658998966217041,
0.16980822384357452,
-0.1421755999326706,
-0.10340706259012222,
0.08866675943136215,
0.06164787709712982,
-0.05945543944835663,
0.5772786736488342,
-0.13313034176826477,
0.005194447934627533,
0.09584486484527588,
-0.03264328092336655,
0.12397215515375137,
0.16706661880016327,
-0.08181899785995483,
0.05993075668811798,
-0.24858498573303223,
-0.3888300657272339,
0.20826122164726257,
-0.05697603151202202,
-0.09314075857400894,
-0.04720083251595497,
0.1852959394454956,
0.028932033106684685,
0.01374803390353918,
0.03536543622612953,
0.028773603960871696,
0.14453020691871643,
0.09898058325052261,
-0.3131835460662842,
0.09659087657928467,
-0.011913237161934376,
-0.013968663290143013,
0.04762972518801689,
-0.008527752943336964,
-0.040921781212091446,
0.0014613191597163677,
-0.03540545329451561,
0.032305821776390076,
-0.09202494472265244,
-0.05449659749865532,
-0.08061937242746353,
0.025664033368229866,
-0.29251185059547424,
0.08481156826019287,
-0.22367508709430695,
0.2912258803844452,
0.254973441362381,
-0.14622730016708374,
-0.01158137060701847,
0.16505217552185059,
-0.38263240456581116,
-0.07356464117765427,
-0.14794185757637024,
0.12013987451791763,
0.29202577471733093,
-0.21413971483707428,
-0.1543673723936081,
0.015058458782732487,
0.043003831058740616,
0.1316002458333969,
0.3096131980419159,
0.04879293963313103,
-0.05669211596250534,
-0.16856218874454498,
0.195331409573555,
-0.10548419505357742,
0.11627718806266785,
-0.21721601486206055,
0.03614150732755661,
-0.32347434759140015,
-0.0026759831234812737,
-0.005167605821043253,
-0.2580936551094055,
-0.46591758728027344,
-0.0617908239364624,
0.16656610369682312,
-0.058887265622615814,
0.09092896431684494,
0.3306247293949127,
0.1838056594133377,
0.15487170219421387,
0.10346915572881699,
0.442255437374115,
0.05150965228676796,
0.06979042291641235,
0.05925440043210983,
0.13860251009464264,
-0.31158700585365295,
0.1270376294851303,
-0.04541324824094772,
-0.34020495414733887,
0.25956839323043823,
-0.11366710066795349,
0.2290576994419098,
-0.13976290822029114,
-0.09592093527317047,
-0.006212096661329269,
-0.20297643542289734,
0.27367526292800903,
-0.20250648260116577,
-0.060612209141254425,
0.06501517444849014,
-0.15643830597400665,
-0.05859946087002754,
0.04455495998263359,
-0.06588201969861984,
0.02903061732649803,
-0.19437667727470398,
0.10801420360803604,
-0.09309642761945724,
0.2711976170539856,
-0.05235839635133743,
0.07055755704641342,
-0.17876295745372772,
-0.14407308399677277,
0.29162585735321045,
0.11078459024429321,
-0.27990958094596863,
-0.587209165096283,
-0.1775614619255066,
0.019575979560613632,
-0.27955663204193115,
0.20092004537582397,
0.23328371345996857,
0.06318661570549011,
0.23541375994682312,
0.40866756439208984,
0.013366958126425743,
0.0183202363550663,
-0.020157691091299057,
-0.1061648428440094,
-0.21979084610939026,
-0.05996835604310036,
-0.15814043581485748,
-0.08690350502729416,
-0.008059969171881676,
0.0836237370967865,
-0.15216515958309174,
0.17978163063526154,
-0.17850802838802338,
-0.010884992778301239,
-0.014607642777264118,
0.11783533543348312,
0.0847579762339592,
0.393446683883667,
0.14503982663154602,
-0.00770770525559783,
0.1884174942970276,
-0.1111362874507904,
-0.07814323902130127,
-0.2776414453983307,
-0.03241083398461342,
-0.04489191994071007,
-0.10783465206623077,
0.05549896880984306,
0.13838036358356476,
-0.029440604150295258,
0.10188599675893784,
-0.036272142082452774,
-0.29301631450653076,
-0.11017785966396332,
0.08744394034147263,
-0.2580745220184326,
-0.11946980655193329,
0.026020491495728493,
-0.05909224599599838,
-0.1564619094133377,
0.2361202836036682,
0.027280928567051888,
0.16178810596466064,
-0.211333766579628,
-0.20766581594944,
-0.32748597860336304,
0.2768038809299469,
-0.1750923991203308,
0.026419231668114662,
-0.5551902651786804,
0.1194591224193573,
0.12017800658941269,
-0.1045752540230751,
-0.09154963493347168,
0.1735229194164276,
-0.06331842392683029,
0.18484435975551605,
-0.2998412251472473,
0.24682150781154633,
0.10346534103155136,
-0.025902705267071724,
-0.06813446432352066,
0.020598668605089188,
-0.34992551803588867,
-0.1657055765390396,
-0.05079038441181183,
-0.13036981225013733,
-0.10256903618574142,
-0.1545587033033371,
0.05016399919986725,
0.1458168625831604,
0.10005956888198853,
0.0924743264913559,
0.06741505116224289,
0.01629343442618847,
-0.1580023318529129,
0.0785083994269371,
-0.02612133137881756,
-0.2767251133918762,
-0.06930073350667953,
0.03462573513388634,
0.03717513754963875,
-0.05692416429519653,
0.020059285685420036,
-0.0007635400397703052,
-0.0690024197101593,
-0.12740309536457062,
0.13065868616104126,
0.16068638861179352,
0.0499122180044651,
0.24983634054660797,
-0.014209936372935772,
0.2589540481567383,
0.11261666566133499,
0.1538921296596527,
0.02117261290550232,
-0.0038800423499196768,
-0.022317349910736084,
0.11220943927764893,
-0.13408732414245605,
0.2919418215751648,
0.0263442974537611,
-0.014321152120828629,
-0.04059034213423729,
0.1451990157365799,
-0.22272305190563202,
-0.10044236481189728,
-0.08976072818040848,
0.07951649278402328,
0.09041839838027954,
0.16434010863304138,
0.10223949700593948,
-0.061628252267837524,
-0.17200122773647308,
-0.1517534703016281,
0.14180904626846313,
0.20028440654277802,
-0.005643289536237717,
0.310695081949234,
-0.02818514220416546,
-0.2401571273803711,
0.09591465443372726,
-0.0173035915941,
-0.11822817474603653,
-0.03709207847714424,
0.11572176218032837,
-0.017022307962179184,
0.2955521047115326,
0.16947120428085327,
0.012322347611188889,
-0.012533839792013168,
0.2025037705898285,
0.12463031709194183,
-0.18665775656700134,
-0.07213231176137924,
-0.08616282790899277,
0.021062633022665977,
-0.21901695430278778,
0.12232937663793564,
-0.07458063215017319,
0.13859477639198303,
0.16451126337051392,
0.01785806007683277,
-0.06474089622497559,
-0.19400286674499512,
0.29757872223854065,
0.10791855305433273,
0.006176270078867674,
-0.06317109614610672,
0.12283357232809067,
-0.33379173278808594,
0.04465215280652046,
-0.5711095333099365,
-0.3575042486190796,
0.11309551447629929,
0.159409761428833,
0.23889665305614471,
0.06470903754234314,
-0.03851167485117912,
-0.13688157498836517,
-0.001649531302973628,
-0.15761712193489075,
-0.17821547389030457,
0.11484993249177933,
0.02721823938190937,
-0.09941211342811584,
0.03261178359389305,
0.22785617411136627,
0.08164766430854797,
-0.22843264043331146,
0.24014587700366974,
0.045538339763879776,
-0.05657922104001045,
0.20467838644981384,
0.019576488062739372,
-0.26091253757476807,
0.07317706197500229,
0.04338129237294197,
-0.1815418004989624,
0.1355714648962021,
0.24568022787570953,
-0.05826767534017563,
-0.13303454220294952,
-0.003879185998812318,
0.22394683957099915,
-0.12147137522697449,
-0.043390173465013504,
-0.2287142425775528,
-0.17714178562164307,
-0.009377251379191875,
0.2188478261232376,
0.26874855160713196,
0.09326112270355225,
0.19278106093406677,
0.1479579508304596,
-0.2192842960357666,
0.023457849398255348,
0.06149660423398018,
-0.3432358205318451,
-0.007960760034620762,
0.18338926136493683,
0.03273782506585121,
0.12891951203346252,
-0.09616869688034058,
0.13628821074962616,
-0.011686919257044792,
0.08412393927574158,
-0.14007669687271118,
-0.028401106595993042,
-0.011866819113492966,
0.0845322534441948,
0.47799572348594666,
0.09764482825994492,
0.3007100522518158,
0.14567986130714417,
0.1879786252975464,
-0.04049030691385269,
-0.2746845781803131,
0.13021337985992432,
0.03173630312085152,
-0.17550323903560638,
0.05745316296815872,
-0.2107907086610794,
-0.26365694403648376,
-0.022975049912929535,
-0.05387048423290253,
-0.016435690224170685,
0.19761623442173004,
-0.20102372765541077,
-0.07024593651294708,
-0.2703162729740143,
0.06888874620199203,
-0.051787905395030975,
-0.01011429913341999,
0.06844468414783478,
0.05221225321292877,
0.006247576791793108,
0.06308472901582718,
-0.033534370362758636,
0.17988675832748413,
0.07517696171998978,
0.1214805319905281,
0.07551118731498718,
0.34717658162117004,
0.09497067332267761,
-0.2164621502161026,
0.004178543575108051,
0.1696872115135193,
-0.23865516483783722,
0.06191891059279442,
-0.031999360769987106,
-0.07108712196350098,
-0.11898323148488998,
-0.019624635577201843,
0.19372066855430603,
0.010235999710857868,
0.19120773673057556,
-0.024019552394747734,
-0.037451788783073425,
0.22994184494018555,
-0.20166125893592834,
0.013030116446316242,
-0.09150714427232742,
-0.06231249123811722,
0.04231423884630203,
0.10308188945055008,
-0.26679179072380066,
0.0962686836719513,
0.013950381428003311,
-0.29817113280296326,
0.019783925265073776,
0.20799632370471954,
0.06543751806020737,
0.04593152552843094,
0.3141956627368927,
-0.26073506474494934,
-0.08823180198669434,
0.16504475474357605,
0.20603692531585693,
0.07391313463449478,
-0.0654284805059433,
0.09220719337463379,
0.09946153312921524,
-0.016468221321702003,
-0.25529932975769043,
0.09574466943740845,
0.18725474178791046,
-0.17247575521469116,
0.31580850481987,
-0.027458785101771355,
-0.008830481208860874,
0.02847958728671074,
0.1977543979883194,
0.010680139064788818,
0.1542607992887497,
-0.18869318068027496,
0.1790212094783783,
0.37222376465797424,
-0.08865653723478317,
0.11434119939804077,
-0.027316274121403694,
0.12054143100976944,
0.35481566190719604,
-0.1668718159198761,
-0.17239677906036377,
-0.0845084935426712,
-0.0997805967926979,
0.01997719146311283,
0.051049474626779556,
-0.06168706715106964,
-0.09239837527275085,
-0.11055954545736313,
0.1519450545310974,
0.062302302569150925,
0.12952615320682526,
0.012545758858323097,
-0.16188029944896698,
0.011342651210725307,
0.09370584785938263,
0.16270041465759277,
0.07462397962808609,
0.03478303551673889,
-0.09544704854488373,
0.07869293540716171,
-0.1021280437707901,
0.1630629450082779,
0.08756919950246811,
0.010620837099850178,
-0.28024840354919434,
0.2835612893104553,
0.18806184828281403,
0.2782008647918701,
0.25355952978134155,
-0.19213157892227173,
-0.13806307315826416,
0.188473179936409,
0.1715477705001831,
-0.119033582508564,
-0.09165320545434952,
-0.018390405923128128,
-0.1944686770439148,
-0.25535380840301514,
0.18832232058048248,
0.30845701694488525,
-0.06151644513010979,
-0.07918782532215118,
0.03598390892148018,
-0.09891189634799957,
-0.0122549869120121,
0.02951132133603096,
0.0414603054523468,
-0.19243347644805908,
0.1135052815079689,
-0.24310077726840973,
0.19180935621261597,
0.10487562417984009,
0.2138463258743286,
0.19280627369880676,
-0.00046366555034182966,
0.0306342002004385,
-0.31541696190834045,
-0.06766485422849655,
-0.005241678096354008,
-0.017134131863713264,
-0.09537014365196228,
-0.0197906494140625,
-0.26040229201316833,
-0.06146613508462906,
0.032090868800878525,
-0.09850499778985977,
-0.16028784215450287,
-0.06939204782247543,
0.07621097564697266,
0.13449786603450775,
0.1283235102891922,
0.034169863909482956,
0.06351317465305328,
-0.08207491785287857,
0.024150492623448372,
-0.1915186643600464,
0.04587670788168907,
0.16370521485805511,
0.019013285636901855,
-0.11908150464296341,
0.1806352734565735,
-0.054936233907938004,
-0.3278435170650482,
-0.10784300416707993,
-0.034126296639442444,
-0.08363573998212814,
0.09928644448518753,
0.3354213237762451,
0.016464490443468094,
-0.016878126189112663,
0.0019841718021780252,
-0.09535407274961472,
0.2550126612186432,
0.27996698021888733,
0.09476432204246521,
0.0905568078160286,
-0.3688379228115082,
0.18599650263786316,
-0.06988201290369034,
0.10341913998126984,
-0.03815694898366928,
0.15526710450649261,
-0.18879903852939606,
-0.035878680646419525,
0.08926154673099518,
0.15371385216712952,
0.29911693930625916,
0.19593718647956848,
-0.06865199655294418,
-0.08486725389957428,
0.10038375109434128,
0.1375301331281662,
-0.1728965789079666,
0.13893738389015198,
0.058986492455005646,
0.14812907576560974,
0.03792821615934372,
0.2078038603067398,
0.08330786973237991,
0.0046677798964083195,
-0.08322847634553909,
0.020587285980582237,
-0.19307537376880646,
0.1153549924492836,
-0.12012026458978653,
0.16431479156017303,
0.07184445858001709,
0.1852196455001831,
-0.05407484620809555,
-0.21937523782253265,
0.11771635711193085,
-0.21798811852931976,
-0.016730008646845818,
-0.09919752180576324,
-0.18309864401817322,
0.051066625863313675,
0.14722029864788055,
-0.06416505575180054,
-0.0890929251909256,
-0.14720329642295837,
-0.08413626998662949,
0.042174097150564194,
0.2025023251771927,
0.07388954609632492,
0.015735775232315063,
-0.16056175529956818,
-0.06262553483247757,
-0.07688428461551666,
0.21749654412269592,
-0.13318392634391785,
0.20400647819042206,
0.010078693740069866,
-0.09895969182252884,
-0.0057958075776696205,
-0.15351656079292297,
0.0909138098359108,
-0.03586769104003906,
-0.016115231439471245,
-0.019209718331694603,
0.40073513984680176,
-0.12295325100421906,
0.038424357771873474,
-0.1849806010723114,
0.10581868886947632,
-0.09972655773162842,
0.11484085768461227,
-0.036685772240161896,
-0.09342734515666962,
0.0882369801402092,
-0.15132634341716766,
-0.05030658096075058,
0.10920728743076324,
-0.12272083014249802,
-0.08883354067802429,
0.014085180126130581,
-0.1717386245727539,
0.018217522650957108,
-0.10482127964496613,
0.1385715752840042,
0.24926500022411346,
0.1580411195755005,
-0.010703934356570244,
0.14026223123073578,
-0.1548084020614624,
0.12900668382644653,
-0.09846761077642441,
-0.27203142642974854,
-0.21420566737651825,
-0.08485082536935806,
0.1662028729915619,
0.33435195684432983,
0.09852758795022964,
-0.013421976007521152,
0.2048138976097107,
-0.28632137179374695,
0.042520128190517426,
-0.06984858214855194,
0.09467872232198715,
0.22279608249664307,
-0.07664607465267181,
-0.21381503343582153,
0.3268877863883972,
-0.12365326285362244,
-0.2944450080394745,
-0.03048507310450077,
-0.11740144342184067,
0.10372164100408554,
-0.03343186154961586,
0.15638607740402222,
0.05521199479699135,
-0.20217856764793396,
0.20786309242248535,
-0.1632353812456131,
0.045799244195222855,
-0.1574731022119522,
-0.039788998663425446,
-0.18794257938861847,
-0.09910714626312256,
0.23355785012245178,
0.15461423993110657,
0.15368518233299255,
-0.10075396299362183,
0.1386447548866272,
-0.19510388374328613,
-0.23843127489089966,
-0.031925301998853683,
0.0418902263045311,
-0.05891169607639313,
0.14154361188411713,
-0.2002151608467102,
-0.11387366056442261,
0.1109401062130928,
0.23493807017803192,
0.010818034410476685,
-0.04763685539364815,
-0.2501084804534912,
-0.16190533339977264,
-0.24128542840480804,
0.19533856213092804,
-0.11501936614513397,
-0.08838417381048203,
0.0365125946700573,
-0.06075790524482727,
-0.07750683277845383,
0.072379931807518,
-0.16654980182647705,
0.250179648399353,
0.13029378652572632,
0.030807549133896828,
0.1054682582616806,
0.27981069684028625,
-0.17012059688568115,
-0.027325652539730072,
0.02864372543990612,
-0.2784525752067566,
0.06436402350664139,
0.1996069997549057,
0.05739481374621391,
-0.042239073663949966,
0.014660525135695934,
-0.012916818261146545,
-0.35106468200683594,
-0.2936951816082001,
-0.001306729158386588,
-0.04896453395485878,
-0.12084519863128662,
-0.026759278029203415,
0.09559318423271179,
0.1741493046283722,
-0.11426371335983276,
0.10797242075204849,
0.014824017882347107,
0.1379169523715973
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. central lines), frequent hospitalizations, and potential nutritional deficiencies caused by dietary modification. Although staphylococcal scalded skin syndrome and Candida skin infections were reported in the earlier literature , more recent natural history studies suggest that such complications are uncommon .Hypogammaglobulinemia, B-cell lymphopenia, decreased CD4 and CD8 counts, and abnormal CD4/CD8 ratio have been described . Hypogammaglobulinemia, reported in as many as 15% of affected individuals, has required treatment with immunoglobulin in some cases .Ophthalmologic
manifestations. Eye findings include dyschromatopsia, optic atrophy, scotomas, abnormal electroretinogram, visual evoked potentials, and optical coherent tomography. In addition, optic tract and cortical abnormalities have been occasionally noted .Optic neuropathy occurs in 11%-25% . The onset of optic neuropathy can be acute or insidious; further deterioration can occur during metabolic decompensations triggered by infections or surgery . The mean age of diagnosis is approximately 13 years (range 2-24 | [
0.18657320737838745,
-0.023549214005470276,
-0.001303251483477652,
-0.16070570051670074,
-0.03973858058452606,
0.09193170070648193,
0.014631648547947407,
-0.15501904487609863,
-0.2873055636882782,
0.1872505396604538,
0.18637940287590027,
0.05599023401737213,
0.0038510956801474094,
-0.05763579532504082,
-0.3723941445350647,
-0.01785934902727604,
-0.1257951408624649,
0.14371970295906067,
-0.005773093085736036,
-0.13965047895908356,
-0.025702359154820442,
-0.28054431080818176,
0.30526161193847656,
0.06616024672985077,
-0.12324236333370209,
-0.3340361416339874,
0.09865675121545792,
-0.059837937355041504,
0.0699552372097969,
0.10489042103290558,
0.10378306359052658,
-0.14470677077770233,
0.16309918463230133,
-0.10088714957237244,
0.16902939975261688,
-0.23728440701961517,
-0.04022805392742157,
-0.24389362335205078,
0.0639289990067482,
-0.43487194180488586,
0.028332142159342766,
-0.16053780913352966,
0.11559790372848511,
0.09494370222091675,
0.19291940331459045,
-0.1986452043056488,
-0.05004959926009178,
-0.01024785079061985,
-0.2510110139846802,
0.14732754230499268,
0.20513944327831268,
-0.204888716340065,
-0.1766684353351593,
0.10206931829452515,
-0.004320198204368353,
-0.09185170382261276,
-0.24997073411941528,
0.2850992679595947,
0.07238861173391342,
0.049663759768009186,
0.11473270505666733,
-0.20061498880386353,
-0.1333329975605011,
-0.3412654399871826,
0.23245128989219666,
0.024746624752879143,
-0.12108569592237473,
0.20487289130687714,
0.16121001541614532,
-0.14195403456687927,
0.1597682684659958,
-0.10606211423873901,
-0.009130476973950863,
0.1275920867919922,
-0.2721024751663208,
0.13171525299549103,
0.10411129891872406,
-0.08346562832593918,
0.17336787283420563,
-0.3116573095321655,
0.04410705715417862,
-0.05244477465748787,
-0.1476881355047226,
-0.08298824727535248,
0.009082827717065811,
0.1948644518852234,
0.07959826290607452,
-0.1116989478468895,
0.10822872817516327,
0.21685096621513367,
0.19351214170455933,
0.10095305740833282,
-0.10144087672233582,
-0.04008118435740471,
-0.015768835321068764,
-0.10313082486391068,
-0.06675505638122559,
-0.1445586383342743,
0.09388668835163116,
0.18115206062793732,
-0.0718630850315094,
0.09665396064519882,
-0.15972678363323212,
-0.09918577969074249,
-0.25437286496162415,
-0.04239102080464363,
-0.38514888286590576,
0.2624077796936035,
-0.12867005169391632,
0.17472372949123383,
0.18722672760486603,
-0.15428811311721802,
-0.0046309963800013065,
0.07537958770990372,
-0.26359114050865173,
0.06560511142015457,
-0.04631132259964943,
-0.02198013849556446,
0.2146388441324234,
-0.14761842787265778,
0.13097652792930603,
-0.013178303837776184,
0.03824211284518242,
0.21279212832450867,
0.050486840307712555,
-0.004500431474298239,
-0.11570090055465698,
0.03638327866792679,
0.17644834518432617,
-0.11884892731904984,
0.10140497982501984,
-0.029290806502103806,
-0.05314285308122635,
-0.14767365157604218,
-0.004204802215099335,
-0.04374956712126732,
-0.43796101212501526,
-0.3864537179470062,
0.026203149929642677,
-0.01293936837464571,
0.10477156192064285,
0.14691507816314697,
0.21746206283569336,
0.25237929821014404,
0.19884184002876282,
0.11671300232410431,
0.3412013351917267,
-0.035295724868774414,
0.18652290105819702,
0.09848273545503616,
-0.017612040042877197,
-0.10723503679037094,
0.1323504000902176,
-0.09564576297998428,
-0.37990719079971313,
0.37823954224586487,
-0.05475641041994095,
0.05928327888250351,
-0.23036935925483704,
-0.004199855495244265,
-0.003939170390367508,
-0.16741639375686646,
0.0919731929898262,
-0.17541508376598358,
-0.029220513999462128,
0.17180347442626953,
-0.17355528473854065,
-0.12958282232284546,
0.06971582770347595,
-0.03500816971063614,
-0.00834550429135561,
-0.19793064892292023,
0.022484062239527702,
-0.05029017850756645,
0.20216597616672516,
-0.0030566200148314238,
-0.0654900074005127,
-0.14459137618541718,
-0.1412089616060257,
0.05460371449589729,
-0.031847935169935226,
-0.16793635487556458,
-0.4111969470977783,
-0.08299503475427628,
-0.048072703182697296,
-0.2806518077850342,
0.14965644478797913,
0.13551253080368042,
-0.10578698664903641,
0.030532831326127052,
0.19450733065605164,
0.1654236614704132,
0.03489416837692261,
-0.140812948346138,
-0.13567090034484863,
-0.04483144357800484,
-0.1875939816236496,
-0.24742643535137177,
-0.14408525824546814,
-0.06898464262485504,
0.17040927708148956,
-0.05681900680065155,
0.09654593467712402,
-0.07946836948394775,
-0.10995957255363464,
-0.24481621384620667,
0.17287759482860565,
0.032092541456222534,
0.1645280122756958,
0.05697351694107056,
0.1486922949552536,
0.011022769846022129,
-0.013148615136742592,
0.12940926849842072,
-0.16256268322467804,
0.15945354104042053,
0.0007590183522552252,
0.07395723462104797,
0.016515465453267097,
-0.06894466280937195,
0.07055947184562683,
0.38392865657806396,
-0.025915903970599174,
-0.3410103917121887,
-0.30509936809539795,
0.098333440721035,
-0.3361848294734955,
-0.2084045112133026,
-0.1610940843820572,
-0.08052365481853485,
-0.20571637153625488,
0.10068512707948685,
0.01721714250743389,
-0.00098133715800941,
-0.0829910933971405,
-0.28582730889320374,
-0.20296144485473633,
0.2585102319717407,
-0.2216581553220749,
0.11900132894515991,
-0.4854990243911743,
0.09962239861488342,
-0.031918589025735855,
-0.1694425642490387,
-0.15364110469818115,
0.36777883768081665,
0.0132716353982687,
0.22434644401073456,
-0.08462100476026535,
0.05731955170631409,
0.04083500802516937,
0.061700157821178436,
-0.05823374539613724,
0.04269861429929733,
-0.3622530698776245,
-0.16186581552028656,
0.16575908660888672,
-0.02083614468574524,
0.15781334042549133,
-0.0003859126300085336,
0.025862501934170723,
0.17323848605155945,
-0.0803963914513588,
-0.028995903208851814,
-0.05332745611667633,
-0.1114729568362236,
-0.13366413116455078,
0.09140266478061676,
-0.009437726810574532,
-0.20828184485435486,
-0.15818944573402405,
0.18604062497615814,
0.1081349179148674,
0.042453620582818985,
-0.03796256333589554,
-0.0835304707288742,
-0.017573777586221695,
-0.03191806375980377,
0.04733150079846382,
0.1556844711303711,
-0.025508103892207146,
0.039858195930719376,
0.08496451377868652,
0.13484571874141693,
0.18311364948749542,
0.11523018777370453,
0.02633349597454071,
-0.14520861208438873,
-0.05800554156303406,
0.06126382201910019,
-0.02802310138940811,
0.21336214244365692,
-0.09468047320842743,
-0.07789032906293869,
0.1047600582242012,
-0.007634568493813276,
-0.06417960673570633,
-0.016985272988677025,
-0.04999607428908348,
0.2147325724363327,
0.05245671421289444,
0.0877394825220108,
-0.00544526195153594,
0.06908491253852844,
-0.20442454516887665,
-0.10065960139036179,
0.19306680560112,
0.14505331218242645,
0.018004773184657097,
0.2390018105506897,
0.09900414943695068,
-0.22503788769245148,
0.17205610871315002,
0.02024388685822487,
-0.13271518051624298,
0.01031971350312233,
0.006344101391732693,
0.1105019673705101,
0.3346925377845764,
0.21530623733997345,
-0.025615327060222626,
0.0870499238371849,
0.0778854489326477,
0.1204633116722107,
-0.0004921577638015151,
0.09024830162525177,
0.08007816970348358,
0.15821634232997894,
-0.23331037163734436,
0.23567549884319305,
-0.030869081616401672,
-0.10103926062583923,
0.0017947774613276124,
-0.03482793644070625,
0.215648353099823,
-0.2030700296163559,
0.2457459270954132,
0.09634168446063995,
0.09029010683298111,
-0.11719440668821335,
0.1623653918504715,
-0.0873427614569664,
0.08585920184850693,
-0.28506749868392944,
-0.29593342542648315,
0.14047271013259888,
-0.029955977573990822,
0.15407422184944153,
0.14656999707221985,
-0.10603895038366318,
-0.011518203653395176,
0.06104658171534538,
-0.031129537150263786,
-0.0887867882847786,
0.06183888763189316,
-0.04983868449926376,
-0.17710986733436584,
0.020742196589708328,
0.3853834271430969,
0.004116487689316273,
-0.32217490673065186,
0.18733105063438416,
0.0239303857088089,
-0.16387024521827698,
0.16339537501335144,
0.03937705606222153,
-0.10158983618021011,
0.17086444795131683,
0.08809022605419159,
-0.10630881041288376,
0.2704649269580841,
0.11115120351314545,
-0.007096929010003805,
-0.03798120096325874,
0.1841098666191101,
0.11168172955513,
-0.2549522817134857,
-0.06923841685056686,
-0.3103801906108856,
-0.1323600709438324,
-0.02752101793885231,
0.32460135221481323,
0.14112509787082672,
0.19483350217342377,
0.2962205111980438,
0.09507805109024048,
-0.12174886465072632,
0.13027141988277435,
0.24114371836185455,
-0.1373550444841385,
0.025572793558239937,
0.2338358759880066,
0.08106907457113266,
0.4834621548652649,
-0.07275544106960297,
0.10882554948329926,
0.021682387217879295,
0.033315569162368774,
-0.12793602049350739,
-0.015071995556354523,
-0.05218414217233658,
0.12678644061088562,
0.34056082367897034,
-0.08477877825498581,
0.2461189180612564,
0.1284165233373642,
0.13709375262260437,
0.14002488553524017,
-0.29903364181518555,
-0.0406859889626503,
0.011693703010678291,
-0.10934273898601532,
-0.08442294597625732,
-0.1458318829536438,
-0.32652547955513,
0.09220371395349503,
-0.05268266797065735,
0.10919733345508575,
0.31986507773399353,
-0.16324572265148163,
-0.07893714308738708,
-0.21493564546108246,
0.1209743469953537,
-0.10699518769979477,
0.07097379863262177,
0.11499642580747604,
0.13668672740459442,
0.15905658900737762,
0.05837599188089371,
-0.05139491334557533,
0.11030404269695282,
0.02569957822561264,
0.13208504021167755,
0.04750896990299225,
0.21570470929145813,
0.11430540680885315,
0.07243833690881729,
-0.12861688435077667,
0.254944384098053,
-0.24729935824871063,
0.08912621438503265,
0.06658276915550232,
-0.11147159337997437,
-0.001733281766064465,
-0.06801155209541321,
0.249256893992424,
-0.04430355876684189,
0.05663621053099632,
-0.29726850986480713,
0.060560472309589386,
0.15047034621238708,
-0.11776561290025711,
0.08966264128684998,
-0.007732657250016928,
-0.07311107218265533,
0.03280337527394295,
0.012898833490908146,
-0.18631552159786224,
0.01145365834236145,
0.12033749371767044,
-0.32249218225479126,
-0.06513189524412155,
0.2629062235355377,
0.05508417263627052,
0.035341471433639526,
0.2309352308511734,
-0.12470289319753647,
-0.35552963614463806,
0.20639093220233917,
0.07251931726932526,
0.05187090486288071,
-0.1801104098558426,
-0.07722768932580948,
-0.02149871364235878,
0.021495025604963303,
-0.19106659293174744,
0.005181055516004562,
0.11810797452926636,
-0.0013539092615246773,
0.13054800033569336,
-0.03754044696688652,
-0.005021151155233383,
0.18769946694374084,
0.135403111577034,
-0.19067341089248657,
0.2324666678905487,
-0.07692550867795944,
0.2085176706314087,
0.3238208293914795,
0.016929782927036285,
-0.03028029203414917,
-0.019392311573028564,
0.01593266986310482,
0.20677627623081207,
-0.19092369079589844,
-0.14861246943473816,
-0.10074987262487411,
-0.021437887102365494,
0.21011093258857727,
-0.12706004083156586,
0.021299617365002632,
0.10824519395828247,
-0.18613798916339874,
-0.07670033723115921,
-0.13453270494937897,
0.10800271481275558,
-0.009784320369362831,
-0.1958710253238678,
0.07442452013492584,
-0.055709999054670334,
0.03671450540423393,
0.1987110823392868,
-0.005835976917296648,
0.053842633962631226,
0.13973407447338104,
-0.2176421582698822,
0.010936519131064415,
0.17812694609165192,
0.0919497162103653,
-0.3682251274585724,
0.17949163913726807,
0.06993909925222397,
0.17348980903625488,
0.0707424208521843,
-0.14941783249378204,
-0.18871690332889557,
0.295192688703537,
0.14022374153137207,
-0.2626112997531891,
-0.09757672250270844,
-0.12293324619531631,
-0.3159244954586029,
-0.27417227625846863,
0.2705882489681244,
0.19769985973834991,
-0.15288116037845612,
0.005803280510008335,
0.04636673256754875,
0.1202295571565628,
-0.04836127534508705,
-0.05490047484636307,
0.17875999212265015,
-0.01787494868040085,
0.12636539340019226,
-0.15168820321559906,
0.3002842664718628,
0.14082323014736176,
0.054136715829372406,
-0.0005530790076591074,
-0.02128767780959606,
-0.25524210929870605,
-0.1281081885099411,
0.02469501458108425,
0.2418893426656723,
-0.03663320094347,
-0.3544878363609314,
-0.12422352284193039,
-0.33283931016921997,
-0.20923109352588654,
0.031790073961019516,
-0.052645038813352585,
-0.23318877816200256,
-0.07902369648218155,
0.0999956727027893,
0.12822729349136353,
-0.07594795525074005,
-0.16894511878490448,
0.25179287791252136,
-0.046993404626846313,
-0.08208233118057251,
-0.03897073492407799,
-0.08321022987365723,
0.02592593990266323,
0.0370841845870018,
-0.1734704077243805,
0.11051096022129059,
-0.11539395898580551,
-0.2523966133594513,
-0.12117625772953033,
-0.06319565325975418,
0.16814689338207245,
0.0016004107892513275,
0.14754317700862885,
0.009338326752185822,
0.1560477465391159,
0.11432215571403503,
0.025195924565196037,
0.06667420268058777,
0.3164820969104767,
0.031039651483297348,
-0.015073827467858791,
-0.3246901035308838,
-0.05463513359427452,
0.09187626093626022,
0.10311850160360336,
-0.0021279496140778065,
0.29898837208747864,
-0.18238495290279388,
-0.009224982932209969,
0.15148530900478363,
0.018986595794558525,
0.20559187233448029,
0.03984437510371208,
-0.0065298667177557945,
-0.2122233808040619,
0.07891282439231873,
0.12208836525678635,
-0.11235944926738739,
0.12180669605731964,
-0.04714864492416382,
0.2463882863521576,
-0.013200225308537483,
0.2463318556547165,
0.08309391885995865,
0.10582849383354187,
-0.04986985772848129,
0.18006347119808197,
0.03896522521972656,
0.00673322007060051,
-0.22776569426059723,
0.18625465035438538,
-0.044602762907743454,
0.19645144045352936,
-0.16876117885112762,
-0.09220254421234131,
0.19872020184993744,
-0.07712862640619278,
-0.06888997554779053,
-0.05230456218123436,
-0.09812428802251816,
-0.05136523023247719,
0.15603068470954895,
-0.03168066218495369,
-0.1610669493675232,
-0.22660410404205322,
-0.022129764780402184,
0.10135573893785477,
0.37237870693206787,
0.24316179752349854,
-0.009999540634453297,
-0.03915047645568848,
-0.0329112634062767,
0.06878001242876053,
0.17893663048744202,
-0.04783983901143074,
0.03397819772362709,
0.020103732123970985,
-0.2090381681919098,
-0.04373830184340477,
0.003407852491363883,
-0.08714346587657928,
-0.1477816104888916,
-0.18909741938114166,
0.09831573814153671,
0.17911061644554138,
-0.04677131026983261,
-0.1707221120595932,
-0.30912885069847107,
0.09805487841367722,
-0.025518342852592468,
-0.036263249814510345,
-0.13480065762996674,
-0.1520424783229828,
0.27926746010780334,
-0.08615617454051971,
-0.2225254625082016,
0.26479530334472656,
-0.10073599964380264,
0.012484603561460972,
0.01555300410836935,
-0.29470089077949524,
-0.027025548741221428,
-0.17514190077781677,
0.018889574334025383,
0.17036819458007812,
0.27528566122055054,
-0.24315086007118225,
0.142449289560318,
-0.20751029253005981,
0.27867352962493896,
-0.12732890248298645,
-0.44898346066474915,
-0.17177990078926086,
-0.010415755212306976,
0.11254240572452545,
0.4520772397518158,
-0.12466683238744736,
0.14261460304260254,
-0.05520262569189072,
-0.32279765605926514,
0.0012052884558215737,
0.2159091681241989,
0.0489744134247303,
0.2182321399450302,
-0.1387905478477478,
-0.04499907046556473,
0.18825720250606537,
-0.18273508548736572,
-0.2741483747959137,
-0.058081526309251785,
-0.10986770689487457,
-0.014665097929537296,
-0.026048487052321434,
-0.1490325629711151,
-0.0313100628554821,
-0.08150530606508255,
0.38538554310798645,
-0.05183172971010208,
0.016223132610321045,
0.0705723837018013,
0.02543741464614868,
-0.11074140667915344,
-0.00334180542267859,
0.3117803633213043,
0.061618030071258545,
0.0054582939483225346,
-0.13573957979679108,
0.36938127875328064,
-0.1376352459192276,
-0.17247618734836578,
0.17434988915920258,
0.002194608561694622,
0.07832562923431396,
0.14175143837928772,
-0.07850053161382675,
-0.015586958266794682,
0.06364034116268158,
0.23694166541099548,
0.09878510981798172,
-0.02307882346212864,
-0.20279107987880707,
-0.17184317111968994,
-0.1752239316701889,
0.1277371495962143,
0.025277940556406975,
0.01567922905087471,
0.008939030580222607,
-0.13009364902973175,
-0.03767256438732147,
-0.09738896042108536,
-0.04661918058991432,
0.1373794972896576,
-0.031805817037820816,
0.0842619463801384,
0.1525198370218277,
0.19540239870548248,
-0.06856895983219147,
-0.07263750582933426,
-0.16007840633392334,
-0.19691802561283112,
0.007174082566052675,
0.19136270880699158,
0.20725950598716736,
0.09109240025281906,
0.026451941579580307,
-0.04964838922023773,
-0.1611156016588211,
-0.3547620475292206,
-0.14389632642269135,
-0.10430905967950821,
-0.21717585623264313,
0.014847160317003727,
-0.21736548840999603,
0.5427905321121216,
-0.117014579474926,
0.1457546502351761,
0.0939665138721466,
0.11953949183225632
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. in some cases .Ophthalmologic
manifestations. Eye findings include dyschromatopsia, optic atrophy, scotomas, abnormal electroretinogram, visual evoked potentials, and optical coherent tomography. In addition, optic tract and cortical abnormalities have been occasionally noted .Optic neuropathy occurs in 11%-25% . The onset of optic neuropathy can be acute or insidious; further deterioration can occur during metabolic decompensations triggered by infections or surgery . The mean age of diagnosis is approximately 13 years (range 2-24 years) .Hearing loss. Sensorineural hearing loss was reported in 1% and 13% in two large cohorts of individuals with PA .Musculoskeletal system. Severe osteopenia and osteoporosis have been described in adults with PA .Dermatologic manifestations resembling acrodermatitis enteropathica are frequently associated with deficiency of essential amino acids, particularly isoleucine, which can be inadvertently over-restricted in the diet of persons with PA .Other rare complications.
Isolated case reports describe clinical findings that could be causally | [
0.07991161942481995,
0.04383889585733414,
0.02008950710296631,
-0.08964993804693222,
-0.013813315890729427,
-0.087690070271492,
0.0913483276963234,
-0.04360734671354294,
-0.13159696757793427,
0.17896658182144165,
0.19367018342018127,
0.12894490361213684,
-0.11614847928285599,
-0.00046370315249077976,
-0.4026589095592499,
0.08471889048814774,
-0.04455311968922615,
0.03520357608795166,
-0.04961853101849556,
-0.16680912673473358,
-0.16631850600242615,
-0.24975353479385376,
0.21241141855716705,
-0.049623437225818634,
-0.018671007826924324,
-0.3280295431613922,
0.023822082206606865,
-0.122034952044487,
0.1861834079027176,
0.035693030804395676,
-0.006909110117703676,
-0.1805349886417389,
0.16562587022781372,
-0.14380791783332825,
0.2869408428668976,
-0.14942364394664764,
-0.07495302706956863,
-0.28051137924194336,
0.027940891683101654,
-0.4196508526802063,
0.18664216995239258,
-0.12338036298751831,
0.30374082922935486,
0.003522132523357868,
0.13873007893562317,
-0.06022313982248306,
-0.04049922898411751,
0.01682463102042675,
-0.1160980835556984,
0.19603997468948364,
0.1696285903453827,
-0.2600424289703369,
-0.26167067885398865,
0.06009921804070473,
0.007199187763035297,
-0.302064448595047,
-0.33450499176979065,
0.3327033519744873,
0.13056986033916473,
0.1488904058933258,
0.11162450909614563,
-0.09489750862121582,
-0.22603839635849,
-0.3090422749519348,
0.3418727517127991,
-0.01175698172301054,
-0.06333182007074356,
0.20089063048362732,
0.1839156597852707,
-0.13085967302322388,
0.2777755558490753,
-0.106814444065094,
-0.08877658098936081,
-0.002773223677650094,
-0.2286262810230255,
-0.10175154358148575,
0.007043399382382631,
-0.034603461623191833,
0.1700483113527298,
-0.2744617164134979,
-0.04434460029006004,
-0.032813575118780136,
-0.03944165259599686,
-0.26030510663986206,
0.06605549156665802,
0.1815049946308136,
0.13411539793014526,
-0.1244920939207077,
-0.03618883341550827,
0.4125281572341919,
0.17241983115673065,
-0.0063482304103672504,
-0.12306422740221024,
-0.027290942147374153,
-0.06740948557853699,
0.028551237657666206,
0.15738047659397125,
-0.11346805095672607,
0.017242679372429848,
0.20167432725429535,
0.005828112363815308,
0.05482124909758568,
-0.26937931776046753,
-0.17021480202674866,
-0.15181827545166016,
0.0731624886393547,
-0.22074751555919647,
0.2131674736738205,
-0.029080478474497795,
0.16982343792915344,
0.27782365679740906,
0.002539585344493389,
0.2551839053630829,
-0.1586606502532959,
-0.3272644281387329,
0.23006585240364075,
-0.00935838371515274,
0.23685219883918762,
0.09425564855337143,
-0.1823776364326477,
0.27881813049316406,
0.009243500418961048,
-0.0154386842623353,
0.12397319078445435,
-0.01738620549440384,
0.04179723933339119,
0.004002527333796024,
0.038752418011426926,
0.02817797102034092,
-0.18744555115699768,
0.1354244351387024,
-0.10062266141176224,
0.09803668409585953,
-0.296521931886673,
0.036170538514852524,
0.029742874205112457,
-0.36776915192604065,
-0.4401077330112457,
-0.1229354739189148,
-0.029113298282027245,
0.09842148423194885,
0.1255214661359787,
0.2830536663532257,
0.45937004685401917,
0.32956382632255554,
0.19274476170539856,
0.26014623045921326,
-0.0927419364452362,
0.2656981945037842,
0.050413280725479126,
-0.12903083860874176,
-0.10306582599878311,
0.2021450400352478,
0.022173743695020676,
-0.2580277621746063,
0.30053165555000305,
-0.1899375021457672,
0.003118880558758974,
-0.24690808355808258,
-0.03850115090608597,
-0.04372592270374298,
-0.20196953415870667,
-0.05902490019798279,
-0.04968613013625145,
0.050331324338912964,
0.12400119751691818,
-0.3036070764064789,
-0.04140312969684601,
-0.03339708223938942,
-0.03411194309592247,
-0.06359118223190308,
-0.12208296358585358,
0.07649794220924377,
0.00551140820607543,
0.17230607569217682,
0.0058418442495167255,
-0.0647646114230156,
-0.08209932595491409,
-0.1272527128458023,
0.25165021419525146,
0.05224218964576721,
-0.151661217212677,
-0.298005074262619,
-0.12161397933959961,
-0.20013383030891418,
-0.14627978205680847,
0.08714723587036133,
0.11187805980443954,
-0.21997348964214325,
-0.0061498526483774185,
0.07169325649738312,
0.11555863916873932,
0.16725291311740875,
-0.08531425148248672,
-0.11962471157312393,
-0.06043431535363197,
-0.12987859547138214,
-0.22802527248859406,
-0.2383410930633545,
0.0241756159812212,
0.07702578604221344,
-0.1450720876455307,
0.2229108065366745,
-0.1724562793970108,
-0.09139160066843033,
-0.22692912817001343,
0.08841772377490997,
0.017202820628881454,
0.05563107505440712,
0.10186605155467987,
0.05875997245311737,
0.31288984417915344,
-0.22699664533138275,
-0.003415933344513178,
-0.18675903975963593,
-0.0017681377939879894,
0.05920302867889404,
0.050914157181978226,
0.012280987575650215,
0.01721263863146305,
0.0010315869003534317,
0.27360105514526367,
-0.049269452691078186,
-0.2866474390029907,
-0.3137640953063965,
0.11377138644456863,
-0.33950212597846985,
-0.15353257954120636,
-0.10087447613477707,
-0.035617150366306305,
-0.24633543193340302,
0.1465444266796112,
0.18173164129257202,
0.08499546349048615,
0.11868944019079208,
-0.39212581515312195,
-0.21939361095428467,
0.26853424310684204,
-0.23523133993148804,
0.037304800003767014,
-0.5441830158233643,
0.14193114638328552,
0.06074798107147217,
0.011786221526563168,
-0.24016031622886658,
0.3223746418952942,
-0.13939467072486877,
0.2322620451450348,
0.043027497828006744,
0.14223825931549072,
0.0069569614715874195,
0.06600052863359451,
0.021949542686343193,
-0.11598626524209976,
-0.34390759468078613,
-0.07367786765098572,
0.3724144697189331,
-0.007202645763754845,
0.36264893412590027,
-0.00315033458173275,
0.008376248180866241,
0.1447318196296692,
-0.03861292451620102,
-0.13528569042682648,
-0.05897312983870506,
0.1387091875076294,
-0.053069472312927246,
0.2803964614868164,
-0.033305417746305466,
-0.2699575424194336,
-0.04636969044804573,
0.19101037085056305,
0.13717201352119446,
0.06772897392511368,
-0.2225647121667862,
-0.1821233481168747,
-0.03499053791165352,
0.03996773809194565,
0.10213421285152435,
0.13032758235931396,
-0.1323169320821762,
-0.03134850785136223,
-0.10007408261299133,
0.10816401243209839,
0.34027811884880066,
0.10196984559297562,
-0.09363678842782974,
-0.06954742968082428,
-0.10931497812271118,
0.06905698776245117,
0.00134789920412004,
0.12038276344537735,
-0.12869539856910706,
-0.026316571980714798,
0.1795700043439865,
0.004366933833807707,
0.018211059272289276,
0.029216110706329346,
-0.1920640468597412,
0.1345655769109726,
0.18013663589954376,
0.024012485519051552,
0.15519464015960693,
0.11551841348409653,
-0.17433246970176697,
-0.10542718321084976,
0.04840816929936409,
-0.004379728808999062,
0.08769075572490692,
0.25592201948165894,
0.08615368604660034,
-0.10021895915269852,
0.09026846289634705,
0.10849981755018234,
-0.10168355703353882,
-0.18826809525489807,
-0.04384644702076912,
0.2169104367494583,
0.24890661239624023,
0.20946873724460602,
-0.05114004760980606,
0.08717493712902069,
0.14227710664272308,
0.12555089592933655,
-0.02116067335009575,
0.09829825907945633,
0.047249969094991684,
0.11272331327199936,
-0.16668277978897095,
0.22917050123214722,
-0.19419638812541962,
0.11976975947618484,
0.13155944645404816,
-0.13263803720474243,
0.15481895208358765,
-0.25876379013061523,
0.23031708598136902,
0.09862996637821198,
-0.043191127479076385,
0.12014059722423553,
0.18055827915668488,
-0.13722598552703857,
0.1921793669462204,
-0.21494750678539276,
-0.37711986899375916,
0.16778254508972168,
-0.06308285892009735,
0.4009265899658203,
0.2901199460029602,
-0.107488252222538,
0.13539071381092072,
0.07035524398088455,
-0.11189555376768112,
-0.02649811841547489,
0.11803551018238068,
-0.07866969704627991,
-0.44176700711250305,
0.039877306669950485,
0.5282100439071655,
0.05053145810961723,
-0.39019742608070374,
0.09897522628307343,
0.17793644964694977,
-0.24042339622974396,
0.12396591156721115,
-0.08894097059965134,
-0.13308371603488922,
0.03199731558561325,
0.14823763072490692,
-0.10660282522439957,
0.1423880010843277,
0.010382408276200294,
0.10527113080024719,
0.1697942614555359,
0.09648287296295166,
0.05290750414133072,
-0.29859459400177,
-0.13467377424240112,
-0.36938998103141785,
-0.10251821577548981,
-0.00542152114212513,
0.1924927532672882,
0.16315557062625885,
0.06043152138590813,
0.16950549185276031,
0.1658020168542862,
-0.03655612841248512,
0.2923586368560791,
0.3053346276283264,
-0.2462332844734192,
0.05641888454556465,
0.24772368371486664,
0.04984502121806145,
0.36119887232780457,
-0.18586720526218414,
0.07436880469322205,
0.012440877966582775,
0.13543270528316498,
-0.08357392996549606,
0.10350360721349716,
0.06277094036340714,
0.18778188526630402,
0.14234741032123566,
-0.10921010375022888,
0.3445783257484436,
0.18910640478134155,
0.0419263131916523,
0.21114715933799744,
-0.35373154282569885,
-0.05232098698616028,
-0.029441887512803078,
-0.2497413009405136,
0.05630628019571304,
0.07339323312044144,
-0.07945655286312103,
-0.020346349105238914,
-0.1661437749862671,
0.10180763900279999,
0.42754387855529785,
-0.20058169960975647,
-0.2845122516155243,
-0.08352312445640564,
-0.012482325546443462,
-0.07168789952993393,
-0.2724883258342743,
0.12118084728717804,
0.05250193178653717,
0.11851102113723755,
0.01737954281270504,
-0.010099612176418304,
0.038282379508018494,
0.007196421269327402,
0.07919305562973022,
0.12005776166915894,
0.28758493065834045,
0.09866748005151749,
-0.009373988956212997,
-0.09337609261274338,
0.118039570748806,
-0.024196024984121323,
0.22889219224452972,
-0.08629707992076874,
-0.15072669088840485,
-0.013678359799087048,
-0.12188633531332016,
0.32253143191337585,
-0.04772171005606651,
0.05840890109539032,
-0.23662051558494568,
0.005328602623194456,
0.1894836574792862,
-0.11563084274530411,
0.08506316691637039,
0.09672091901302338,
0.005735567770898342,
0.11037256568670273,
0.005261740647256374,
-0.3054336905479431,
-0.0068109892308712006,
0.22078394889831543,
-0.3598448634147644,
-0.13650716841220856,
0.1489715427160263,
-0.23232412338256836,
-0.10671601444482803,
0.3303127586841583,
-0.3268296420574188,
-0.0922926515340805,
0.16373039782047272,
0.17330411076545715,
0.11708547919988632,
0.005060890689492226,
-0.1271960586309433,
0.17737963795661926,
-0.23568953573703766,
-0.3018108308315277,
-0.03941482678055763,
-0.013863535597920418,
-0.02631504274904728,
0.15121160447597504,
-0.09025856852531433,
0.07143919914960861,
0.22044847905635834,
0.053344931453466415,
-0.13815230131149292,
0.17528174817562103,
-0.16364267468452454,
0.05997888371348381,
0.38926997780799866,
0.07834544032812119,
0.07437672466039658,
-0.07808341085910797,
0.004279551096260548,
0.267045795917511,
-0.0815354660153389,
-0.18645276129245758,
-0.02590123936533928,
-0.10391896963119507,
0.16589559614658356,
-0.2278369963169098,
-0.07238291203975677,
-0.16476601362228394,
-0.30721813440322876,
-0.10937618464231491,
0.07916837930679321,
0.017399130389094353,
0.11065429449081421,
-0.1381918340921402,
-0.11576160788536072,
0.02968919463455677,
-0.003935026470571756,
0.3461170196533203,
-0.1119966134428978,
-0.12110010534524918,
0.05757361650466919,
-0.154163658618927,
0.18718630075454712,
0.3728850185871124,
0.06787200272083282,
-0.2997530996799469,
0.07150281220674515,
0.17523925006389618,
0.28760412335395813,
-0.027506127953529358,
-0.10953199863433838,
-0.1263650804758072,
0.332499235868454,
0.18809732794761658,
-0.16806870698928833,
-0.19978106021881104,
0.05235707387328148,
-0.39327308535575867,
-0.1233895793557167,
0.07194339483976364,
0.2148984670639038,
-0.17614226043224335,
-0.01830419711768627,
-0.0013274806551635265,
0.2358199506998062,
-0.03571733087301254,
-0.19949114322662354,
0.29953691363334656,
-0.07333289831876755,
0.12197095900774002,
-0.2060849815607071,
0.08459579944610596,
0.18928812444210052,
0.051984723657369614,
0.030078282579779625,
-0.06447106599807739,
-0.1155499741435051,
0.0041566817089915276,
-0.003765293164178729,
0.2710301876068115,
-0.12362229824066162,
-0.45574602484703064,
-0.03552042320370674,
-0.13993963599205017,
-0.2068357765674591,
-0.03322528675198555,
-0.09552863240242004,
-0.07259051501750946,
-0.04848792031407356,
0.1706768125295639,
-0.0902990847826004,
0.0005783046362921596,
-0.12143862247467041,
0.24738138914108276,
-0.11627650260925293,
-0.11820584535598755,
-0.0671723484992981,
-0.010982372798025608,
0.007327876053750515,
-0.14444153010845184,
-0.1885184794664383,
0.03187708929181099,
-0.3022575080394745,
-0.36663228273391724,
-0.00033833779161795974,
0.030770644545555115,
0.22877110540866852,
0.05708176642656326,
0.14807376265525818,
-0.12612996995449066,
0.2509160041809082,
0.021195104345679283,
0.09754107147455215,
0.1370362490415573,
0.30619531869888306,
0.0815991461277008,
-0.08370472490787506,
-0.3092697858810425,
0.023147733882069588,
0.00819274503737688,
0.03355659916996956,
0.03242403641343117,
0.2619567811489105,
-0.11212436109781265,
0.05820006504654884,
0.19421839714050293,
0.07932671904563904,
0.10530112683773041,
0.04986640438437462,
-0.11417844891548157,
-0.24271772801876068,
-0.029060542583465576,
0.2537800669670105,
-0.1928524672985077,
-0.06210251525044441,
-0.004368179012089968,
0.38134101033210754,
0.12867213785648346,
0.18982262909412384,
0.12276963889598846,
0.2383679747581482,
-0.04212859645485878,
0.24775750935077667,
0.16298866271972656,
0.020486097782850266,
-0.07517209649085999,
0.31717488169670105,
0.05969247221946716,
0.19778399169445038,
-0.21033795177936554,
-0.1784176230430603,
0.27482733130455017,
-0.14603620767593384,
-0.2190040498971939,
-0.012130798771977425,
-0.10253623872995377,
0.025395909324288368,
0.3855777978897095,
0.16667066514492035,
-0.05516021326184273,
-0.28364431858062744,
0.09684932231903076,
0.1628442406654358,
0.36863598227500916,
0.05590316653251648,
0.04008783772587776,
-0.44190436601638794,
0.1514466255903244,
-0.07980275899171829,
0.1576545685529709,
-0.08849875628948212,
0.052692826837301254,
-0.04233706369996071,
-0.09675006568431854,
0.05836421623826027,
-0.0550350546836853,
-0.04666103050112724,
-0.15132968127727509,
-0.03440793976187706,
0.1553167998790741,
0.0722556859254837,
-0.08068646490573883,
0.027224993333220482,
-0.05048433691263199,
0.12948726117610931,
-0.14214952290058136,
-0.015458902344107628,
-0.10083907097578049,
0.0030284461099654436,
0.24198484420776367,
-0.28048908710479736,
-0.0807877704501152,
0.1511843353509903,
-0.07366130501031876,
-0.050511423498392105,
-0.21311146020889282,
-0.20893435180187225,
-0.047678060829639435,
-0.10802178084850311,
0.02852773107588291,
0.06185239925980568,
0.21584753692150116,
-0.13230398297309875,
-0.027066057547926903,
-0.22087743878364563,
0.28582918643951416,
-0.08067262172698975,
-0.530116081237793,
-0.2886662483215332,
0.0551726408302784,
0.0009242328233085573,
0.2666514217853546,
-0.08577796816825867,
0.035218194127082825,
-0.07502546161413193,
-0.3961971402168274,
0.06640653312206268,
0.16733549535274506,
0.08100675791501999,
0.17602860927581787,
-0.05626733973622322,
0.06527099758386612,
0.5125854015350342,
-0.1551455855369568,
-0.30567649006843567,
-0.2767229378223419,
-0.3546350598335266,
-0.007545426953583956,
-0.10150019079446793,
0.06077131628990173,
-0.0749221220612526,
-0.11744605004787445,
0.23101499676704407,
-0.0853656530380249,
0.009926129132509232,
0.041057080030441284,
-0.06987093389034271,
-0.26421698927879333,
-0.15800896286964417,
0.28138968348503113,
0.10890291631221771,
-0.004469487350434065,
-0.07012472301721573,
0.16805973649024963,
-0.12212907522916794,
-0.25518032908439636,
0.26757240295410156,
0.06856169551610947,
-0.06773518025875092,
0.1757604330778122,
-0.0904870480298996,
0.1594889909029007,
0.062292490154504776,
0.1365593522787094,
0.1841367930173874,
-0.036793991923332214,
-0.15655863285064697,
-0.20928971469402313,
-0.1705806702375412,
0.0797458216547966,
-0.22073818743228912,
-0.12820297479629517,
0.13934430480003357,
-0.20557965338230133,
-0.023708615452051163,
-0.06194143369793892,
-0.09846773743629456,
0.09627758711576462,
0.024173984304070473,
-0.007602047640830278,
0.025141742080450058,
0.14590586721897125,
0.04372653365135193,
-0.16272200644016266,
-0.11575169116258621,
-0.2756401300430298,
-0.16093526780605316,
0.06055401638150215,
0.3750084340572357,
0.06060327962040901,
0.1151496022939682,
-0.06598132848739624,
-0.10420840233564377,
-0.3225771188735962,
-0.10163998603820801,
0.002488377969712019,
-0.028492897748947144,
-0.04075208678841591,
-0.34590303897857666,
0.36743125319480896,
-0.13349488377571106,
0.24340106546878815,
0.1476058065891266,
0.007666569668799639
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. years (range 2-24 years) .Hearing loss. Sensorineural hearing loss was reported in 1% and 13% in two large cohorts of individuals with PA .Musculoskeletal system. Severe osteopenia and osteoporosis have been described in adults with PA .Dermatologic manifestations resembling acrodermatitis enteropathica are frequently associated with deficiency of essential amino acids, particularly isoleucine, which can be inadvertently over-restricted in the diet of persons with PA .Other rare complications.
Isolated case reports describe clinical findings that could be causally associated with propionic acidemia, but require further characterization: muscle lipidosis ; myopathy ; premature ovarian insufficiency ; oligomenorrhea ; hypothyroidism ; parathyroid hormone resistance resolving after hemodialysis .Life span. PA confers a high risk of mortality. Reported mortality rates appear to be on the decline: 41%-90% in the 1980-90s, 17%-72% in 2000s, and 7%-12% in early 2010s . Observed decline in reported mortality likely reflects | [
-0.045368317514657974,
-0.07939286530017853,
-0.016263404861092567,
-0.04325006529688835,
0.09870124608278275,
-0.09634113311767578,
0.09889896959066391,
0.006549743469804525,
-0.04848453029990196,
0.10401702672243118,
0.16754812002182007,
0.025694403797388077,
-0.1782282441854477,
0.09767524152994156,
-0.4663083851337433,
0.1970505714416504,
-0.11147593706846237,
-0.022958096116781235,
-0.08734942972660065,
-0.07283854484558105,
-0.04356539249420166,
-0.12768664956092834,
0.12815506756305695,
-0.006377814803272486,
0.21715663373470306,
-0.23527057468891144,
0.04403802379965782,
-0.23407535254955292,
0.25155648589134216,
-0.14917758107185364,
0.00923632737249136,
-0.04483348876237869,
-0.062365494668483734,
-0.2994212210178375,
0.1991042047739029,
-0.08510789275169373,
-0.0342312753200531,
-0.33489200472831726,
0.02208527736365795,
-0.44460931420326233,
0.2429758906364441,
-0.04172293096780777,
0.32402676343917847,
-0.0601421520113945,
0.11271213740110397,
-0.08504147827625275,
-0.058463435620069504,
0.006148151122033596,
0.0187612883746624,
0.025007592514157295,
0.18132449686527252,
-0.354266881942749,
-0.21435114741325378,
-0.0715564414858818,
0.07821942865848541,
-0.30034831166267395,
-0.1886090636253357,
0.20019719004631042,
0.1505429744720459,
0.11831767857074738,
0.05539070442318916,
-0.04432538524270058,
-0.31072235107421875,
-0.3098640739917755,
0.3973708152770996,
0.03278594836592674,
-0.043869804590940475,
0.08105699717998505,
0.09521739929914474,
-0.05835997313261032,
0.33840319514274597,
-0.05900929868221283,
-0.060006070882081985,
0.007349023129791021,
-0.0843825489282608,
-0.18751737475395203,
0.1766001135110855,
0.03326201066374779,
0.14668767154216766,
-0.28861841559410095,
-0.3044361472129822,
0.06927970796823502,
-0.008924003690481186,
-0.19134163856506348,
0.06465990096330643,
0.13754083216190338,
0.08609586954116821,
-0.044443003833293915,
-0.12504121661186218,
0.2504577338695526,
0.06854566931724548,
-0.022695031017065048,
-0.11972778290510178,
0.031506653875112534,
-0.0032925372943282127,
0.12329365313053131,
0.18416740000247955,
-0.06068912148475647,
-0.2010960727930069,
0.0944371297955513,
0.08270101249217987,
0.038809288293123245,
-0.1994931846857071,
-0.1899147629737854,
0.01753837615251541,
0.00765232602134347,
-0.10249095410108566,
0.05143005773425102,
0.03164822235703468,
0.25204697251319885,
0.3075062036514282,
-0.02253069169819355,
0.28871631622314453,
-0.06188333034515381,
-0.3850342631340027,
0.10005892813205719,
-0.09285257011651993,
0.43839332461357117,
0.07507625222206116,
-0.12259696424007416,
0.22686778008937836,
0.0694296583533287,
-0.10580210387706757,
0.1739429533481598,
-0.0527157224714756,
-0.03814445808529854,
0.08812681585550308,
-0.04304052144289017,
0.025210602208971977,
-0.16999103128910065,
0.07914091646671295,
-0.17215053737163544,
0.16728682816028595,
-0.3220353126525879,
0.08654183149337769,
-0.07316736876964569,
-0.26222142577171326,
-0.4031025767326355,
-0.034983858466148376,
0.0061532785184681416,
0.09734436869621277,
0.20189890265464783,
0.31283900141716003,
0.36002129316329956,
0.28881439566612244,
0.1586664766073227,
0.37945613265037537,
-0.024458078667521477,
0.2258109748363495,
-0.08638474345207214,
-0.05976218357682228,
-0.11693765223026276,
0.12846848368644714,
0.070614293217659,
-0.018834972754120827,
0.22946840524673462,
-0.13629525899887085,
0.15243612229824066,
-0.2125532031059265,
-0.04542401805520058,
0.04134001582860947,
-0.22489672899246216,
0.002323791617527604,
-0.08629362285137177,
-0.042761340737342834,
0.006551398895680904,
-0.26123666763305664,
0.09127554297447205,
-0.013680515810847282,
-0.043366048485040665,
-0.04244612902402878,
-0.04235880821943283,
0.07929454743862152,
-0.07151356339454651,
0.0011504479916766286,
0.03219184651970863,
-0.14465610682964325,
-0.15710172057151794,
-0.12846879661083221,
0.2944262623786926,
0.12972910702228546,
-0.15443827211856842,
-0.24786396324634552,
-0.13289472460746765,
-0.02880406565964222,
-0.13963383436203003,
0.11223125457763672,
0.0707763060927391,
-0.014943362213671207,
0.09200652688741684,
0.041107743978500366,
0.10335860401391983,
0.0491814911365509,
0.030190983787178993,
-0.040836408734321594,
-0.1988735795021057,
0.02334931306540966,
-0.14639322459697723,
-0.16855357587337494,
0.0748991146683693,
-0.013977106660604477,
-0.20493090152740479,
0.2764286398887634,
-0.0945124551653862,
-0.05569849908351898,
-0.15431293845176697,
0.01735307276248932,
0.06152467429637909,
0.06158847361803055,
0.04527732729911804,
-0.10369382798671722,
0.3955264389514923,
-0.20741666853427887,
-0.08906847983598709,
-0.2318151593208313,
0.038298651576042175,
0.054507095366716385,
-0.04123111814260483,
-0.03043309412896633,
0.1775958091020584,
-0.023281443864107132,
0.04327262192964554,
0.046980228275060654,
-0.4224618673324585,
-0.21267633140087128,
0.1098380759358406,
-0.37395456433296204,
-0.14435356855392456,
0.10723024606704712,
-0.004143598023802042,
-0.31597158312797546,
0.23556408286094666,
0.2618257701396942,
0.21874870359897614,
0.05639846622943878,
-0.3626418113708496,
-0.03990688920021057,
0.20433421432971954,
-0.19017916917800903,
0.23770466446876526,
-0.5427882075309753,
0.010699046775698662,
0.16306540369987488,
0.03660081699490547,
-0.16853049397468567,
0.1466725915670395,
-0.18677636981010437,
0.1918337047100067,
0.03641125559806824,
0.14609594643115997,
0.0301581509411335,
-0.010684133507311344,
0.11822809278964996,
-0.07923174649477005,
-0.3041270673274994,
0.005599320866167545,
0.3154189884662628,
-0.11514288932085037,
0.2845730781555176,
0.011677617207169533,
-0.017512202262878418,
0.08397915214300156,
0.05883288010954857,
-0.13090093433856964,
-0.056794796139001846,
0.29988551139831543,
-0.14232046902179718,
0.2965219020843506,
-0.06858170032501221,
-0.23018725216388702,
0.09710580855607986,
0.20144961774349213,
0.13625086843967438,
0.10568960756063461,
-0.22264724969863892,
-0.28090742230415344,
-0.15170328319072723,
0.08210684359073639,
0.19315771758556366,
0.03499031066894531,
-0.08770108222961426,
0.08625970035791397,
-0.150619775056839,
0.10926786810159683,
0.20897985994815826,
0.043069057166576385,
-0.12195736169815063,
-0.01793571747839451,
-0.20612819492816925,
0.03702976182103157,
-0.069346122443676,
-0.0403255969285965,
-0.13628263771533966,
-0.15357907116413116,
0.012819688767194748,
0.09037487953901291,
-0.03269823268055916,
-0.12861713767051697,
-0.12052805721759796,
0.003939297050237656,
0.15587656199932098,
0.11518014967441559,
0.25472715497016907,
-0.05321917310357094,
-0.03818504139780998,
0.034627389162778854,
-0.12237551808357239,
-0.047724589705467224,
-0.022319452837109566,
0.257885217666626,
0.03858330100774765,
0.044011615216732025,
-0.03566683083772659,
0.10731850564479828,
-0.02536027692258358,
-0.325344443321228,
-0.002229041885584593,
0.15227724611759186,
0.2967189848423004,
0.15960738062858582,
0.04322101175785065,
0.03996700048446655,
0.11828490346670151,
0.09491302818059921,
-0.10022751986980438,
0.0338781401515007,
0.021700533106923103,
-0.013731352053582668,
-0.18105697631835938,
0.15932218730449677,
-0.28459739685058594,
0.3331909477710724,
0.2150733917951584,
0.012374836020171642,
0.12211001664400101,
-0.16129370033740997,
0.09862072020769119,
0.10348129272460938,
-0.061068035662174225,
0.17823255062103271,
0.06511271744966507,
-0.31152909994125366,
0.10383947193622589,
-0.17214298248291016,
-0.2611352503299713,
0.17752502858638763,
-0.09623575210571289,
0.26780831813812256,
0.20982059836387634,
-0.09956542402505875,
-0.008419051766395569,
0.04369186609983444,
-0.09134162217378616,
0.012731031514704227,
0.15174934267997742,
0.0033492115326225758,
-0.38844749331474304,
-0.09113530069589615,
0.4923677444458008,
0.1958635002374649,
-0.38153156638145447,
0.06475521624088287,
0.12446650862693787,
-0.14218445122241974,
0.09945377707481384,
-0.11190863698720932,
-0.06931550800800323,
-0.10610722750425339,
0.069209024310112,
-0.05619090422987938,
0.12812481820583344,
0.07112471759319305,
0.2163286656141281,
0.21935947239398956,
-0.10146191716194153,
0.24199043214321136,
-0.1925717294216156,
-0.03461798280477524,
-0.30008241534233093,
-0.21219129860401154,
0.021854184567928314,
0.18295809626579285,
0.21456149220466614,
-0.05967723950743675,
-0.008090788498520851,
0.18386024236679077,
-0.026596656069159508,
0.13969634473323822,
0.23676970601081848,
-0.34804683923721313,
0.017794881016016006,
0.14038939774036407,
-0.0845743715763092,
0.11524943262338638,
-0.3544614017009735,
0.017107179388403893,
0.15101660788059235,
0.1935848891735077,
-0.2226901799440384,
0.21642158925533295,
0.014223583042621613,
0.04568884149193764,
0.025513172149658203,
0.09450188279151917,
0.4488953948020935,
0.18879230320453644,
0.003623554715886712,
0.14082877337932587,
-0.18599355220794678,
0.1114753782749176,
-0.07426942139863968,
-0.19232770800590515,
0.10471109300851822,
0.10475333780050278,
-0.008284814655780792,
-0.19720278680324554,
-0.0607733316719532,
0.028390701860189438,
0.3912108540534973,
-0.16366992890834808,
-0.2271275520324707,
-0.01597391441464424,
-0.10558018833398819,
-0.06398236751556396,
-0.36196988821029663,
0.042046621441841125,
0.052085455507040024,
0.026065049692988396,
0.08462642133235931,
0.05353982746601105,
0.13595141470432281,
0.12667346000671387,
0.03279262036085129,
0.1642056405544281,
0.25900378823280334,
-0.0033601964823901653,
-0.1634674072265625,
0.004336092621088028,
0.087948739528656,
-0.04972819238901138,
0.23774117231369019,
-0.05791786313056946,
-0.25887471437454224,
-0.09039650857448578,
-0.12349309772253036,
0.2497193068265915,
0.021317165344953537,
0.11737247556447983,
0.16135863959789276,
0.01097194291651249,
0.2282557338476181,
-0.12333045154809952,
0.013960087671875954,
-0.03561073914170265,
-0.0454513356089592,
0.09435740113258362,
0.16305503249168396,
-0.2918112874031067,
0.05537949129939079,
0.30196163058280945,
-0.37757885456085205,
-0.06461575627326965,
0.12493328750133514,
-0.27076295018196106,
-0.11314387619495392,
0.28211674094200134,
-0.42151936888694763,
0.17007321119308472,
0.1347193568944931,
0.16303503513336182,
0.16834667325019836,
0.032090675085783005,
-0.19844038784503937,
0.18486005067825317,
-0.2530764043331146,
-0.0879029706120491,
-0.1368345022201538,
-0.010472836904227734,
-0.1560356616973877,
0.14109599590301514,
-0.061732836067676544,
0.07290700078010559,
0.031890619546175,
-0.013423782773315907,
-0.08759618550539017,
0.02569045126438141,
-0.103740394115448,
0.024555617943406105,
0.34465429186820984,
0.11379467695951462,
0.14268124103546143,
0.007148938253521919,
-0.011826875619590282,
0.27113497257232666,
-0.08158306032419205,
-0.11984989047050476,
0.07501599937677383,
-0.12075506150722504,
0.019378352910280228,
-0.10505412518978119,
-0.11902155727148056,
-0.278789222240448,
-0.14442642033100128,
0.0024402232374995947,
0.1951574683189392,
-0.03756153956055641,
0.18619117140769958,
-0.017376555129885674,
-0.22810061275959015,
0.19738943874835968,
0.03913923725485802,
0.2594919800758362,
-0.09837941080331802,
-0.209561288356781,
-0.021485792472958565,
-0.16219784319400787,
0.10585620254278183,
0.3018210828304291,
-0.09862012416124344,
-0.3487417995929718,
-0.0007628233870491385,
0.11110478639602661,
0.2092583328485489,
0.06388154625892639,
0.012175139039754868,
-0.06103092059493065,
0.1864786595106125,
0.05456770956516266,
-0.006963927764445543,
-0.3026585280895233,
0.1296079456806183,
-0.22885580360889435,
0.007406586781144142,
-0.047883618623018265,
0.17791549861431122,
-0.11399790644645691,
0.02912619709968567,
0.018853481858968735,
0.17564556002616882,
-0.06899217516183853,
-0.19795005023479462,
0.1740630567073822,
-0.13016006350517273,
0.14588025212287903,
-0.25524792075157166,
-0.02918928861618042,
0.1356935203075409,
0.10911206901073456,
0.04592503234744072,
-0.09503553807735443,
0.07072650641202927,
0.026956887915730476,
-0.13347288966178894,
0.07844455540180206,
-0.07227525115013123,
-0.260501503944397,
-0.02321813628077507,
0.01618979685008526,
-0.1846710741519928,
-0.09962240606546402,
-0.04671153426170349,
-0.0757632926106453,
-0.1414642632007599,
0.05957546830177307,
-0.20379266142845154,
0.017576169222593307,
0.06779036670923233,
0.07862930744886398,
-0.13330143690109253,
-0.04194369539618492,
0.021622905507683754,
0.08277661353349686,
0.08601067960262299,
-0.24871332943439484,
-0.18704445660114288,
0.040774181485176086,
-0.24052532017230988,
-0.3268221616744995,
0.020200176164507866,
0.15776419639587402,
0.058104172348976135,
-0.007224135100841522,
0.2262810915708542,
-0.14108972251415253,
0.3250216245651245,
-0.03087014891207218,
-0.0690954402089119,
0.2990756630897522,
0.1585492491722107,
0.04795817658305168,
-0.0305530596524477,
-0.2942306697368622,
0.11096018552780151,
-0.1324075311422348,
0.07664814591407776,
0.08435310423374176,
0.17067861557006836,
-0.29098352789878845,
0.0440906323492527,
0.05103403329849243,
0.03770056366920471,
0.17290614545345306,
-0.03671741485595703,
-0.08771596848964691,
-0.21800033748149872,
-0.09780912101268768,
0.2576032876968384,
-0.2928719222545624,
-0.12165751308202744,
0.020279549062252045,
0.26733919978141785,
0.17909002304077148,
0.16959084570407867,
0.022838644683361053,
-0.012300134636461735,
-0.09009714424610138,
0.21519885957241058,
-0.011790742166340351,
0.1351136565208435,
-0.12354625016450882,
0.31691619753837585,
0.17153313755989075,
0.13179636001586914,
-0.17600993812084198,
-0.27299121022224426,
0.21705356240272522,
-0.24112844467163086,
-0.1989690214395523,
-0.03970794752240181,
0.024139055982232094,
0.016906026750802994,
0.3401576578617096,
0.02840331941843033,
0.03860568627715111,
-0.31174135208129883,
0.10562846064567566,
0.13871543109416962,
0.22101756930351257,
-0.06289973109960556,
-0.03881502151489258,
-0.3962988555431366,
0.11886750906705856,
-0.09442850202322006,
0.1150280088186264,
-0.18148085474967957,
0.12779518961906433,
-0.20794881880283356,
0.04449392855167389,
0.08336438983678818,
-0.11574868857860565,
0.037179380655288696,
-0.07308202236890793,
0.08977819234132767,
0.1663682609796524,
0.11572675406932831,
-0.12721827626228333,
0.10569291561841965,
0.13674412667751312,
0.21634690463542938,
-0.18150895833969116,
-0.01252109743654728,
-0.02253146842122078,
0.02541414648294449,
0.06644617766141891,
-0.30397018790245056,
0.1152663454413414,
-0.05483635887503624,
-0.08131641894578934,
-0.0021413485519587994,
-0.3420657515525818,
-0.11325300484895706,
0.0068062227219343185,
0.10505372285842896,
0.07845768332481384,
0.030340706929564476,
0.15892760455608368,
-0.0881708636879921,
-0.10035537928342819,
-0.17155413329601288,
0.27614933252334595,
0.011545524001121521,
-0.392736554145813,
-0.20430879294872284,
-0.08464998751878738,
0.06981918960809708,
0.22383472323417664,
0.0805870071053505,
-0.06502166390419006,
0.1626560389995575,
-0.3388279676437378,
0.09186122566461563,
0.06370463222265244,
0.12059278041124344,
0.09696036577224731,
-0.02470972202718258,
0.08605676889419556,
0.6906383633613586,
-0.09427458047866821,
-0.24349498748779297,
-0.3469119071960449,
-0.3491273522377014,
-0.0023963528219610453,
-0.027494486421346664,
0.20125414431095123,
-0.21669280529022217,
-0.22488924860954285,
0.007859567180275917,
-0.11662998795509338,
-0.022304996848106384,
-0.05218673497438431,
-0.273415744304657,
-0.31801947951316833,
-0.16700777411460876,
0.16845381259918213,
0.1003875732421875,
0.022185759618878365,
-0.05500185117125511,
0.1297362595796585,
-0.0689275935292244,
-0.2686678469181061,
0.11975935846567154,
-0.006257042288780212,
0.04751038923859596,
0.09758531302213669,
-0.12238498777151108,
0.08014391362667084,
0.042152289301157,
0.14835099875926971,
0.10990285128355026,
-0.05723460391163826,
-0.21398182213306427,
-0.1145428717136383,
-0.22233843803405762,
0.27045002579689026,
-0.2786591649055481,
-0.0315546952188015,
0.20715558528900146,
-0.027208680287003517,
-0.0009558168821968138,
0.07289820909500122,
-0.16716299951076508,
0.03947460278868675,
0.0328235886991024,
-0.13942363858222961,
-0.08377063274383545,
0.03234466165304184,
-0.00009086060163099319,
-0.18766802549362183,
-0.09911433607339859,
-0.2390618771314621,
-0.336397647857666,
0.017610961571335793,
0.36052995920181274,
0.11563484370708466,
0.24102874100208282,
0.07528049498796463,
-0.15816758573055267,
-0.3915012776851654,
-0.11538822948932648,
0.10196585953235626,
0.01639808528125286,
-0.127203568816185,
-0.08919752389192581,
0.11068601161241531,
-0.13487611711025238,
0.2057788372039795,
0.18465875089168549,
-0.001969747245311737
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. findings that could be causally associated with propionic acidemia, but require further characterization: muscle lipidosis ; myopathy ; premature ovarian insufficiency ; oligomenorrhea ; hypothyroidism ; parathyroid hormone resistance resolving after hemodialysis .Life span. PA confers a high risk of mortality. Reported mortality rates appear to be on the decline: 41%-90% in the 1980-90s, 17%-72% in 2000s, and 7%-12% in early 2010s . Observed decline in reported mortality likely reflects the length of follow up, introduction of newborn screening, expansion of the PA phenotype, proactive medical management, and elective liver transplantation.Long-term adult outcomes. Systematic studies of adult individuals with PA are lacking. Early reports suggest that adults with PA can experience significant osteopenia, osteoporosis, renal failure, and premature ovarian failure .Atypical presentation. Apparently asymptomatic individuals with PA (9%-17% in different cohorts) represent a heterogeneous group consisting of otherwise healthy infants identified after newborn | [
-0.1475985050201416,
-0.08815155178308487,
0.022985195741057396,
-0.07423538714647293,
0.19630864262580872,
-0.055556025356054306,
-0.0037644070107489824,
-0.1540699303150177,
-0.20371796190738678,
0.050293371081352234,
0.1750347763299942,
0.11327382177114487,
-0.11648885905742645,
0.3292677700519562,
-0.2461882382631302,
0.16590207815170288,
-0.07942234724760056,
-0.02510337345302105,
0.019051935523748398,
-0.09156443178653717,
-0.08353962749242783,
-0.14176709949970245,
0.06055266782641411,
0.018611319363117218,
0.19361452758312225,
-0.20430299639701843,
0.1258678436279297,
-0.16257897019386292,
0.18254007399082184,
0.006058739498257637,
-0.01532287523150444,
-0.11301180720329285,
0.14876142144203186,
-0.24302160739898682,
0.13433316349983215,
-0.1565564125776291,
-0.013161438517272472,
0.007973325438797474,
-0.0479360856115818,
-0.13989737629890442,
0.03843330219388008,
-0.1818879097700119,
0.39310067892074585,
0.010801243595778942,
0.10570016503334045,
0.009303073398768902,
0.0651031881570816,
-0.060239821672439575,
-0.017812468111515045,
0.26538723707199097,
0.18271513283252716,
-0.136695995926857,
-0.11338123679161072,
-0.01788513734936714,
0.12511304020881653,
-0.1031089574098587,
-0.1227937862277031,
0.16937430202960968,
-0.08547285199165344,
0.08224382996559143,
0.15285612642765045,
-0.08878640085458755,
-0.20600734651088715,
-0.31713926792144775,
0.11537934839725494,
-0.034452684223651886,
0.147809237241745,
0.14667615294456482,
0.1329699009656906,
-0.13516390323638916,
0.25370028614997864,
-0.0034359379205852747,
0.18629933893680573,
0.1097678691148758,
-0.10935351252555847,
-0.10730142146348953,
0.12008644640445709,
-0.07502026855945587,
0.039552733302116394,
-0.22991211712360382,
-0.20907825231552124,
-0.03811008483171463,
-0.06220588833093643,
-0.06666145473718643,
-0.14791567623615265,
-0.048280052840709686,
0.15058182179927826,
0.24897272884845734,
-0.11330705881118774,
0.03234277665615082,
0.038109876215457916,
-0.0005371205625124276,
-0.16718904674053192,
-0.15849466621875763,
0.10480152070522308,
0.061735931783914566,
0.091208316385746,
0.03454669564962387,
-0.2113105058670044,
-0.03279149532318115,
0.0151359299197793,
0.10520947724580765,
-0.06827805936336517,
-0.08690782636404037,
0.007989027537405491,
0.03249562159180641,
-0.18370510637760162,
0.05443735048174858,
-0.045476458966732025,
0.00459172111004591,
0.19559131562709808,
-0.05590714141726494,
0.13784898817539215,
0.05316012352705002,
-0.3592495024204254,
0.07386407256126404,
-0.1525818258523941,
0.2035442292690277,
0.06298325955867767,
-0.25513026118278503,
0.18545272946357727,
0.003170991549268365,
-0.11799579113721848,
0.01954144798219204,
0.002406912622973323,
0.08036818355321884,
0.034459564834833145,
-0.050356652587652206,
-0.008904566988348961,
-0.02462809719145298,
0.09156293421983719,
0.03461562842130661,
-0.06933456659317017,
-0.2657305598258972,
0.15266375243663788,
-0.05235990136861801,
-0.14798113703727722,
-0.4054652154445648,
-0.14081065356731415,
0.055403612554073334,
0.1018771231174469,
0.2137603610754013,
0.2886130213737488,
0.21465662121772766,
0.3462955057621002,
-0.08295157551765442,
0.45371484756469727,
-0.01411587093025446,
0.19533345103263855,
-0.17507168650627136,
0.08692612498998642,
-0.11749869585037231,
0.1374555081129074,
0.045373741537332535,
-0.042742401361465454,
0.040971022099256516,
0.12265165150165558,
0.30731460452079773,
-0.21260613203048706,
0.043641358613967896,
-0.04848916828632355,
-0.10475880652666092,
0.10300564765930176,
-0.2381165772676468,
-0.09681747108697891,
-0.10236107558012009,
-0.22835175693035126,
0.12518760561943054,
-0.11189772188663483,
-0.13351687788963318,
0.0017312515992671251,
0.018146445974707603,
-0.052753955125808716,
-0.2505201995372772,
-0.11489707976579666,
0.1598043292760849,
-0.03907184302806854,
-0.10281704366207123,
-0.1156521812081337,
0.21575890481472015,
0.10902844369411469,
-0.09512749314308167,
-0.36313119530677795,
0.015383647754788399,
-0.054589319974184036,
-0.1175314337015152,
0.16470840573310852,
0.21112915873527527,
0.10030122101306915,
0.2299482673406601,
0.13708169758319855,
0.07936376333236694,
0.08571814000606537,
0.04080558940768242,
0.028167415410280228,
-0.30359628796577454,
0.1081867441534996,
-0.1176225021481514,
-0.18780387938022614,
-0.03455500677227974,
0.12165802717208862,
-0.13058890402317047,
0.25067421793937683,
-0.10104662925004959,
0.11916158348321915,
-0.2566990852355957,
0.08353108167648315,
0.038789622485637665,
0.13980044424533844,
-0.008716356940567493,
-0.10325274616479874,
0.1925891935825348,
-0.2174438238143921,
-0.09683763980865479,
-0.09270468354225159,
-0.0688912644982338,
-0.06508884578943253,
-0.08457834273576736,
-0.11538238823413849,
0.022741349413990974,
0.0029994440264999866,
0.15559615194797516,
-0.03232033550739288,
-0.2189076691865921,
-0.2803643047809601,
0.10583693534135818,
-0.29234829545021057,
-0.023136185482144356,
0.1171182319521904,
-0.019184021279215813,
-0.23227761685848236,
0.11075779795646667,
0.12561191618442535,
0.23170973360538483,
-0.005694956984370947,
-0.25299641489982605,
-0.11904993653297424,
0.2843175232410431,
-0.05000818148255348,
0.09606002271175385,
-0.26939859986305237,
-0.11967936158180237,
0.20317673683166504,
0.06999269872903824,
0.021950051188468933,
0.009610200300812721,
0.05008182302117348,
0.14429140090942383,
0.0839073657989502,
0.010686548426747322,
-0.07433044165372849,
0.04571782052516937,
0.2074027806520462,
0.036775559186935425,
-0.3263421654701233,
-0.029117992147803307,
0.22117741405963898,
-0.07031256705522537,
0.2262573540210724,
0.0650089681148529,
-0.12421800196170807,
0.18104907870292664,
-0.030569134280085564,
-0.019972272217273712,
-0.09980682283639908,
-0.10467347502708435,
-0.10824913531541824,
0.17046228051185608,
-0.05501313880085945,
-0.23638711869716644,
0.11315151304006577,
0.2538600564002991,
0.20043332874774933,
0.07846657186746597,
-0.25468891859054565,
-0.3621688485145569,
-0.11368805915117264,
-0.008970391936600208,
-0.002689139451831579,
0.015632279217243195,
0.03465745970606804,
0.11749841272830963,
-0.09813087433576584,
0.039194848388433456,
0.20917966961860657,
-0.0510808564722538,
0.0433013029396534,
-0.0029116333462297916,
-0.24922996759414673,
0.14079774916172028,
0.09773155301809311,
0.14317962527275085,
-0.06631704419851303,
-0.08614849299192429,
0.18806929886341095,
0.13520753383636475,
0.01727394200861454,
-0.21470627188682556,
0.0495162233710289,
-0.04116244986653328,
0.13653168082237244,
0.24381570518016815,
0.0694747194647789,
-0.08089378476142883,
-0.11252695322036743,
0.02835724875330925,
0.030244767665863037,
0.011547485366463661,
-0.05923023074865341,
0.20688877999782562,
-0.13516660034656525,
-0.18264183402061462,
-0.11989367008209229,
0.12391220778226852,
-0.1379692703485489,
-0.05775986984372139,
0.009105573408305645,
0.2996319830417633,
0.18462379276752472,
0.1578516811132431,
0.06888141483068466,
-0.10396048426628113,
0.005459460895508528,
0.11850474029779434,
-0.15244367718696594,
0.03676090016961098,
0.03757263720035553,
0.14040111005306244,
-0.14406150579452515,
0.028938479721546173,
0.015420508570969105,
-0.03210192173719406,
-0.05899922177195549,
-0.09245981276035309,
0.17826759815216064,
0.002558850683271885,
0.16905879974365234,
0.15259841084480286,
-0.09503237158060074,
0.08225841075181961,
0.21070866286754608,
-0.3739984333515167,
-0.02340281754732132,
-0.04313962534070015,
-0.14599332213401794,
0.10375770181417465,
-0.11863087862730026,
0.26895731687545776,
-0.017365578562021255,
-0.22923576831817627,
-0.03131977468729019,
-0.10077673196792603,
-0.047917529940605164,
-0.017254378646612167,
0.15721240639686584,
-0.09072040766477585,
-0.11854750663042068,
-0.0004706155159510672,
0.1765802800655365,
0.09136883169412613,
-0.11503926664590836,
0.19331713020801544,
0.00887276791036129,
-0.1039019376039505,
0.05631682276725769,
-0.1543833613395691,
0.028022393584251404,
0.01565736159682274,
0.08289480209350586,
-0.06965333223342896,
0.07372620701789856,
-0.03912697359919548,
0.07137291878461838,
0.07602206617593765,
-0.2350916564464569,
0.2277415692806244,
-0.11700305342674255,
0.11520154029130936,
-0.2248065024614334,
-0.13586412370204926,
-0.014571278356015682,
0.16918453574180603,
-0.010636210441589355,
0.0001128482399508357,
0.04756186529994011,
0.18743903934955597,
-0.08703655749559402,
0.12510961294174194,
0.16054293513298035,
-0.2739563584327698,
0.019712192937731743,
0.09453916549682617,
-0.10745152831077576,
0.07548878341913223,
-0.008905206806957722,
0.026250354945659637,
0.16779381036758423,
0.012206334620714188,
-0.15209877490997314,
0.11397034674882889,
-0.026017338037490845,
-0.08407944440841675,
0.18478147685527802,
0.1786521077156067,
0.23621255159378052,
0.04677300527691841,
0.028004691004753113,
0.04127027466893196,
-0.06478800624608994,
0.21974501013755798,
-0.2103852480649948,
-0.01751631498336792,
0.03320568799972534,
-0.05898969620466232,
-0.07615634799003601,
0.056804392486810684,
0.02551865391433239,
-0.008426092565059662,
0.14903642237186432,
0.054756954312324524,
0.11307971924543381,
-0.041106078773736954,
-0.03038576990365982,
-0.042181238532066345,
-0.3919702172279358,
0.08676058053970337,
0.11422554403543472,
-0.10350405424833298,
-0.07523553818464279,
0.12180279940366745,
0.13987930119037628,
-0.11337263882160187,
-0.030736664310097694,
0.12610764801502228,
0.07499469071626663,
0.050437022000551224,
-0.2482534945011139,
0.03437994420528412,
0.07334384322166443,
-0.12561912834644318,
0.14283233880996704,
-0.11507757008075714,
-0.09102395176887512,
0.055127959698438644,
-0.20811012387275696,
0.2693094313144684,
0.17625248432159424,
-0.04031321033835411,
0.15280139446258545,
0.07082948088645935,
0.0131180789321661,
0.013592452742159367,
-0.015122500248253345,
-0.02006974071264267,
-0.1324944943189621,
0.1783493161201477,
0.12000450491905212,
-0.1239398643374443,
-0.03302129730582237,
0.15737317502498627,
-0.24175773561000824,
-0.007627550512552261,
0.20758920907974243,
-0.03921908140182495,
-0.17878684401512146,
0.22133202850818634,
-0.3142739534378052,
0.20977799594402313,
0.16689780354499817,
-0.04501661658287048,
0.07857077568769455,
-0.08116476982831955,
-0.25000935792922974,
0.031269993633031845,
-0.2706949710845947,
-0.16661286354064941,
-0.16950416564941406,
-0.11376068741083145,
-0.23774833977222443,
0.23210179805755615,
0.06640901416540146,
-0.13025791943073273,
0.07036953419446945,
0.08912878483533859,
0.0551096573472023,
0.01595251075923443,
-0.12412101030349731,
-0.04866449534893036,
0.30454784631729126,
0.2138753980398178,
0.03563421219587326,
0.14020968973636627,
0.005356115754693747,
0.36574533581733704,
-0.15238165855407715,
-0.1817244589328766,
0.011970019899308681,
0.02070690132677555,
-0.04038108140230179,
0.046089790761470795,
-0.12130267173051834,
-0.24232642352581024,
0.04139469563961029,
0.030594903975725174,
-0.008748403750360012,
-0.10550108551979065,
-0.03553842008113861,
-0.03850434347987175,
-0.019955286756157875,
0.36573418974876404,
0.147865429520607,
0.0413980670273304,
0.007427511736750603,
-0.2562442719936371,
0.04187677800655365,
-0.17868266999721527,
-0.035376738756895065,
0.32395583391189575,
-0.16688194870948792,
-0.3724675476551056,
0.16601358354091644,
0.12915971875190735,
0.12697501480579376,
-0.020398342981934547,
0.03697160258889198,
-0.07339929044246674,
0.2129717469215393,
0.1762140840291977,
-0.025066733360290527,
-0.1878986358642578,
0.12044407427310944,
-0.20208606123924255,
0.0042600384913384914,
0.0906737893819809,
0.2818375825881958,
-0.03826402127742767,
0.10785375535488129,
-0.027637729421257973,
-0.07176414132118225,
-0.06785248965024948,
-0.1388874650001526,
0.19244734942913055,
-0.018673425540328026,
0.2435360848903656,
-0.23723739385604858,
0.11978527903556824,
0.19249941408634186,
-0.029889144003391266,
-0.050693683326244354,
0.05334869772195816,
-0.10428114980459213,
-0.02394760772585869,
0.04077693819999695,
0.017236752435564995,
-0.044988833367824554,
-0.18022923171520233,
-0.05546123534440994,
0.00684699509292841,
-0.11817769706249237,
-0.1054999977350235,
-0.059301845729351044,
0.03821267932653427,
-0.11072332412004471,
-0.12787804007530212,
-0.07800287008285522,
0.1406586915254593,
0.03950285166501999,
0.031065622344613075,
-0.010711712762713432,
-0.0344429649412632,
-0.03397069498896599,
0.07031823694705963,
0.11833011358976364,
-0.0843173936009407,
-0.18199053406715393,
-0.020321335643529892,
-0.16230840981006622,
-0.2868414521217346,
0.020437709987163544,
0.06856834143400192,
0.08382018655538559,
-0.18455536663532257,
0.014582977630198002,
-0.0922631248831749,
0.1847020387649536,
0.057127904146909714,
-0.07238373905420303,
0.1409597545862198,
0.1189899891614914,
0.0271310918033123,
-0.08998699486255646,
-0.23194625973701477,
0.13546764850616455,
0.016383163630962372,
0.11354949325323105,
-0.16158603131771088,
0.25215861201286316,
-0.2757938504219055,
-0.12095046043395996,
0.03594556450843811,
0.13126921653747559,
0.2917223870754242,
-0.10973630845546722,
-0.08122580498456955,
-0.07373173534870148,
-0.1718040555715561,
0.0656711757183075,
-0.3358534872531891,
0.06273885071277618,
-0.11722911894321442,
0.042133890092372894,
0.031915660947561264,
0.180376335978508,
-0.07823388278484344,
-0.03895435109734535,
-0.08568799495697021,
0.13774490356445312,
-0.04162755236029625,
0.06650027632713318,
-0.17208458483219147,
0.32877472043037415,
0.23528456687927246,
0.09233410656452179,
-0.23385955393314362,
-0.155791237950325,
0.26867130398750305,
-0.07940271496772766,
-0.17188116908073425,
0.20064811408519745,
-0.0482507199048996,
-0.017285535112023354,
0.046485535800457,
0.05383167043328285,
-0.08635695278644562,
-0.20524464547634125,
-0.11570966243743896,
0.07793162018060684,
0.07375658303499222,
-0.1251838207244873,
-0.1622706949710846,
-0.2470952570438385,
0.09036798030138016,
-0.08056937158107758,
0.03466862067580223,
-0.28540825843811035,
0.22070756554603577,
-0.08509205281734467,
-0.2133110612630844,
-0.17236711084842682,
0.04763022065162659,
-0.0908258706331253,
0.05436549708247185,
-0.05772943049669266,
0.13894279301166534,
0.16027593612670898,
0.029901258647441864,
0.11823847144842148,
-0.031066227704286575,
0.2718358337879181,
-0.21417909860610962,
-0.1800389289855957,
-0.06511151045560837,
0.09024295210838318,
0.047050200402736664,
-0.1508769392967224,
0.046062301844358444,
0.10184939950704575,
-0.01270352117717266,
0.027188723906874657,
-0.31605878472328186,
-0.1959574818611145,
0.13643571734428406,
0.025407707318663597,
-0.0082433195784688,
0.018111838027834892,
-0.03862468898296356,
-0.0862797349691391,
0.07009786367416382,
-0.06388119608163834,
0.39376330375671387,
-0.03029279038310051,
-0.4385828971862793,
-0.13698576390743256,
-0.15639473497867584,
0.06334444135427475,
0.1862058788537979,
0.0013233815552666783,
-0.09109179675579071,
0.04833275079727173,
-0.1660109907388687,
0.11578904837369919,
-0.0937945768237114,
0.30646881461143494,
0.22540134191513062,
0.09519726783037186,
0.03514505922794342,
0.5443015098571777,
-0.05988061800599098,
-0.3303931951522827,
-0.17634829878807068,
-0.16201217472553253,
0.1321151703596115,
0.045448485761880875,
0.16300156712532043,
-0.22357282042503357,
0.052268728613853455,
0.06168140843510628,
-0.12472785264253616,
0.03901448845863342,
-0.10859494656324387,
-0.18498949706554413,
-0.16723351180553436,
0.007292134687304497,
0.32798412442207336,
-0.018323123455047607,
0.23555134236812592,
-0.15323232114315033,
0.22523675858974457,
0.0061613102443516254,
-0.1298132985830307,
-0.038506921380758286,
-0.09490662813186646,
-0.03725026920437813,
-0.09862114489078522,
0.04071347042918205,
0.015382216311991215,
-0.07579243183135986,
0.10719002038240433,
0.11631974577903748,
-0.03604089841246605,
-0.13087362051010132,
-0.13827024400234222,
-0.20829038321971893,
0.23914094269275665,
-0.08175615221261978,
0.16044503450393677,
0.16490663588047028,
0.16509659588336945,
-0.08896558731794357,
-0.07042448222637177,
-0.13315041363239288,
0.08682714402675629,
0.02151923067867756,
0.033645618706941605,
-0.06422874331474304,
-0.023862961679697037,
0.004264816641807556,
-0.1762794405221939,
-0.1282818615436554,
-0.10479162633419037,
-0.029855184257030487,
0.09413309395313263,
0.09888342767953873,
0.17937488853931427,
0.11255363374948502,
0.04628785699605942,
-0.18454594910144806,
-0.21776945888996124,
-0.10641252249479294,
0.034705981612205505,
-0.10422972589731216,
-0.14291803538799286,
-0.0920279398560524,
0.16823109984397888,
-0.3137790858745575,
0.24673910439014435,
0.28889405727386475,
0.05780864134430885
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. decline in reported mortality likely reflects the length of follow up, introduction of newborn screening, expansion of the PA phenotype, proactive medical management, and elective liver transplantation.Long-term adult outcomes. Systematic studies of adult individuals with PA are lacking. Early reports suggest that adults with PA can experience significant osteopenia, osteoporosis, renal failure, and premature ovarian failure .Atypical presentation. Apparently asymptomatic individuals with PA (9%-17% in different cohorts) represent a heterogeneous group consisting of otherwise healthy infants identified after newborn screening, sibs ascertained through evaluation prompted by diagnosis of the proband, and individuals with a diagnosis of PA with incomplete clinical characterization .Genotype-Phenotype CorrelationsAlthough precise genotype-phenotype correlations do not exist, some general comments related to molecular genetics are relevant.Null variants (PCCA: p.Arg313Ter, p.Ser562Ter; PCCB: p.Gly406fs, p.Gly94Ter, and out-of-frame small | [
-0.1227073073387146,
-0.03078470565378666,
0.07092886418104172,
-0.1985594779253006,
0.18018677830696106,
-0.10172054916620255,
0.12129996716976166,
-0.13299882411956787,
-0.19675256311893463,
-0.0415075309574604,
0.19841450452804565,
0.10742063820362091,
-0.05426417291164398,
0.37394997477531433,
-0.2012033760547638,
0.11659426242113113,
-0.045718397945165634,
-0.016671115532517433,
0.008696570992469788,
-0.031266894191503525,
-0.053963880985975266,
-0.1539987474679947,
0.17874713242053986,
-0.03243105486035347,
0.2068949192762375,
-0.18039241433143616,
0.11772214621305466,
-0.24774576723575592,
0.14284320175647736,
0.0376463457942009,
0.09033156931400299,
-0.10481604933738708,
0.18661946058273315,
-0.27287372946739197,
0.050103116780519485,
-0.19431787729263306,
-0.04805856943130493,
0.08757755905389786,
0.0002227633522124961,
-0.1282932460308075,
-0.0004913723678328097,
-0.11992865055799484,
0.36170080304145813,
-0.026240089908242226,
0.16962766647338867,
-0.016499610617756844,
-0.0218119565397501,
0.00993245281279087,
-0.03845076635479927,
0.3676515221595764,
0.17296385765075684,
-0.122431181371212,
-0.081313855946064,
-0.03304591774940491,
0.10078343749046326,
-0.10057083517313004,
-0.1312922239303589,
0.08053869754076004,
-0.1351233571767807,
0.1276739537715912,
0.18207517266273499,
-0.06771305948495865,
-0.1332661360502243,
-0.2860390245914459,
0.12072210758924484,
-0.035366836935281754,
0.10901417583227158,
0.22577516734600067,
0.15200722217559814,
-0.12238453328609467,
0.17577439546585083,
-0.0163221787661314,
0.18927384912967682,
0.04526043310761452,
-0.1500198245048523,
-0.0922057256102562,
0.049052704125642776,
-0.1742718666791916,
0.06579519063234329,
-0.20689807832241058,
-0.2070619910955429,
-0.1361096054315567,
-0.09406448155641556,
-0.11152257025241852,
-0.17466692626476288,
-0.08256074786186218,
0.18427275121212006,
0.10037823766469955,
-0.06384022533893585,
0.10234172642230988,
0.05054435506463051,
-0.048032425343990326,
-0.10142430663108826,
-0.07135937362909317,
0.03670869767665863,
-0.09645745903253555,
0.025337358936667442,
0.05640747770667076,
-0.12836480140686035,
0.025018373504281044,
-0.020228352397680283,
0.10440784692764282,
-0.018260614946484566,
-0.026537006720900536,
-0.08560719341039658,
-0.022374972701072693,
-0.0556587316095829,
0.03230655938386917,
-0.05679692327976227,
0.007736860774457455,
0.21114669740200043,
-0.05447608232498169,
0.24201230704784393,
-0.012435877695679665,
-0.21545642614364624,
0.08731935173273087,
-0.14852464199066162,
0.255492627620697,
0.011909304186701775,
-0.2413109540939331,
0.1546606719493866,
0.0019482348579913378,
-0.0966714546084404,
-0.014106346294283867,
-0.014248468913137913,
0.010108471848070621,
0.034796908497810364,
-0.047403860837221146,
-0.04827693849802017,
0.006021058652549982,
0.11751716583967209,
0.0881175547838211,
-0.1402890533208847,
-0.21656417846679688,
0.18165898323059082,
-0.0707121193408966,
-0.26421624422073364,
-0.447648823261261,
-0.07135121524333954,
0.018603496253490448,
0.14546994864940643,
0.2927302122116089,
0.21322982013225555,
0.25956007838249207,
0.32156768441200256,
0.014490203931927681,
0.40673139691352844,
0.06941679120063782,
0.14350835978984833,
-0.003012509550899267,
0.06213042512536049,
-0.05805802717804909,
0.055808454751968384,
0.14417995512485504,
-0.15994563698768616,
-0.047562375664711,
0.06666446477174759,
0.3657875061035156,
-0.26610037684440613,
0.08056089282035828,
-0.029384680092334747,
-0.029304850846529007,
0.08077024668455124,
-0.2513620853424072,
-0.02809743955731392,
-0.02835324965417385,
-0.18640190362930298,
0.16379830241203308,
-0.06800974905490875,
-0.0648740753531456,
-0.04803821071982384,
-0.0033598619047552347,
-0.029429631307721138,
-0.18435639142990112,
-0.029641060158610344,
0.2171763777732849,
-0.11202442646026611,
-0.14539235830307007,
-0.05719447135925293,
0.2069147229194641,
0.06749632954597473,
-0.0061378940008580685,
-0.3055090010166168,
-0.03898386284708977,
-0.049137670546770096,
-0.09102006256580353,
0.14793670177459717,
0.18310917913913727,
0.04805527999997139,
0.24644735455513,
0.18691837787628174,
0.04371829330921173,
-0.009354624897241592,
-0.07045912742614746,
0.06150166690349579,
-0.18893323838710785,
0.06308235228061676,
-0.02461090497672558,
-0.22323980927467346,
-0.043233491480350494,
0.04317862540483475,
-0.2067219465970993,
0.16420164704322815,
-0.16161878407001495,
0.06480133533477783,
-0.21355301141738892,
0.10860265046358109,
-0.03831659257411957,
0.022586848586797714,
0.10554918646812439,
-0.050814464688301086,
0.235314279794693,
-0.19348952174186707,
-0.0704665258526802,
-0.0692736953496933,
-0.0529162660241127,
-0.045985955744981766,
-0.08347389101982117,
-0.027542440220713615,
-0.02543940581381321,
0.021560661494731903,
0.13920290768146515,
-0.04664062708616257,
-0.14837664365768433,
-0.25784024596214294,
0.042042847722768784,
-0.22005225718021393,
-0.073450468480587,
0.033345289528369904,
-0.06359541416168213,
-0.18903987109661102,
0.026322487741708755,
0.1689770668745041,
0.14410845935344696,
-0.02693556435406208,
-0.2011318951845169,
-0.03124467469751835,
0.3511658310890198,
0.005381894763559103,
0.04688873514533043,
-0.11014255881309509,
-0.17791199684143066,
0.20991948246955872,
0.03262202441692352,
0.07546316087245941,
0.1005384549498558,
0.14839968085289001,
0.14853522181510925,
0.034253738820552826,
0.006228724494576454,
-0.10893267393112183,
0.09072057157754898,
0.1498192399740219,
-0.014405658468604088,
-0.320232629776001,
0.03297009319067001,
0.23853828012943268,
-0.0065354411490261555,
0.10955718159675598,
0.1432940810918808,
-0.06421621888875961,
0.1650095134973526,
0.11631786078214645,
0.016927266493439674,
-0.028511270880699158,
-0.1434205174446106,
-0.07045998424291611,
0.15026311576366425,
-0.06497258692979813,
-0.16965724527835846,
0.049585580825805664,
0.20436671376228333,
0.15060865879058838,
0.16951575875282288,
-0.23605547845363617,
-0.1546797752380371,
-0.0072477287612855434,
0.004410973750054836,
-0.025366351008415222,
0.09358249604701996,
0.016599668189883232,
0.057350341230630875,
-0.1073809564113617,
0.08912679553031921,
0.2060440629720688,
-0.04109317064285278,
0.04420917108654976,
-0.08132468163967133,
-0.09794916212558746,
0.14018461108207703,
0.08003207296133041,
0.1607351005077362,
-0.029997581616044044,
-0.09483615309000015,
0.14730919897556305,
0.2892712354660034,
-0.04314275458455086,
-0.18212191760540009,
-0.04621204733848572,
-0.027484696358442307,
0.1214868575334549,
0.17286619544029236,
0.09420111775398254,
-0.0181889645755291,
-0.15694117546081543,
-0.04765409603714943,
-0.018696725368499756,
-0.015173873864114285,
-0.07959917932748795,
0.2703889012336731,
-0.14894269406795502,
-0.2347036451101303,
-0.19119086861610413,
0.23641721904277802,
-0.043813154101371765,
-0.015868905931711197,
-0.06816953420639038,
0.2923605442047119,
0.14640335738658905,
0.15976235270500183,
0.04095723107457161,
-0.1304236650466919,
0.07310724258422852,
0.09811635315418243,
-0.1800646036863327,
0.11038673669099808,
-0.03725432604551315,
0.09083270281553268,
-0.1805904358625412,
0.00004500254362937994,
0.04476655274629593,
-0.018275385722517967,
0.023504676297307014,
-0.024317096918821335,
0.12790443003177643,
0.020428618416190147,
0.265119343996048,
0.12005163729190826,
-0.039685264229774475,
0.18559160828590393,
0.15655407309532166,
-0.3362628221511841,
-0.08645917475223541,
0.04776924476027489,
-0.10263632237911224,
0.11397169530391693,
-0.048227597028017044,
0.12967567145824432,
0.041765499860048294,
-0.2789511978626251,
0.07205159217119217,
-0.07630536705255508,
-0.05673367530107498,
-0.047149721533060074,
0.19489991664886475,
-0.08300672471523285,
-0.13110944628715515,
0.046412393450737,
0.15049295127391815,
0.056677352637052536,
-0.1576637625694275,
0.16147145628929138,
0.062181584537029266,
-0.16107520461082458,
0.16351091861724854,
-0.19881851971149445,
0.048027534037828445,
0.027423610910773277,
0.13186343014240265,
0.00772810447961092,
0.1708153486251831,
-0.015473623760044575,
0.08913407474756241,
0.02892453595995903,
-0.18171031773090363,
0.26214390993118286,
-0.1255333572626114,
0.16754895448684692,
-0.30297914147377014,
-0.1475052386522293,
-0.006978196557611227,
0.0048359716311097145,
-0.03889858350157738,
-0.03611810877919197,
0.196560338139534,
0.029267795383930206,
-0.0557696595788002,
0.04960431903600693,
0.1295870840549469,
-0.29947179555892944,
0.0249088816344738,
0.07250836491584778,
-0.10564938932657242,
0.10018371045589447,
0.029996993020176888,
0.04690436273813248,
0.11248033493757248,
-0.00018457506666891277,
-0.1105838343501091,
0.14377927780151367,
-0.0934213399887085,
-0.04076596722006798,
0.05340141803026199,
0.15585872530937195,
0.14217768609523773,
0.0017865003319457173,
-0.05093836411833763,
0.03779567405581474,
0.0021839882247149944,
0.18595002591609955,
-0.17073164880275726,
-0.05487886443734169,
-0.03960707038640976,
-0.09278954565525055,
-0.10685130953788757,
0.09652214497327805,
-0.051700543612241745,
-0.06433651596307755,
0.08993025869131088,
-0.0055967653170228004,
0.12023041397333145,
0.0615629218518734,
-0.03250744193792343,
-0.10650128126144409,
-0.3679504692554474,
0.040755923837423325,
0.12347517162561417,
-0.05496203526854515,
-0.126194566488266,
0.04526878520846367,
0.019033052027225494,
-0.07972992211580276,
-0.06310496479272842,
0.08490235358476639,
0.0178885068744421,
0.06081174686551094,
-0.04808546602725983,
-0.021990526467561722,
0.00020969909382984042,
-0.12808828055858612,
0.12365426868200302,
-0.17831093072891235,
-0.06079654395580292,
0.04564064368605614,
-0.1687656193971634,
0.19876492023468018,
0.24929724633693695,
-0.02252163551747799,
0.04987489432096481,
0.06020328029990196,
0.05524415895342827,
-0.06215522810816765,
0.025140011683106422,
-0.03130637854337692,
-0.10306931287050247,
0.09885846823453903,
-0.010413704439997673,
-0.22519031167030334,
0.014595693908631802,
-0.011905011720955372,
-0.3076919615268707,
-0.011508340016007423,
0.17561258375644684,
-0.0676429495215416,
-0.11502565443515778,
0.17602089047431946,
-0.3548961281776428,
0.16795144975185394,
0.0972035676240921,
-0.03283211216330528,
0.07846678793430328,
-0.03439636155962944,
-0.15427637100219727,
0.03013436123728752,
-0.25898051261901855,
-0.1968967765569687,
-0.1288478523492813,
-0.12638528645038605,
-0.13831199705600739,
0.1340441256761551,
0.07388980686664581,
-0.16213099658489227,
0.14708657562732697,
-0.03797673434019089,
0.07801185548305511,
0.04135816544294357,
-0.10704311728477478,
-0.06515926867723465,
0.25123536586761475,
0.09218741208314896,
-0.00913874339312315,
0.1869102567434311,
0.09140755981206894,
0.37158793210983276,
-0.0034777598921209574,
-0.137670636177063,
-0.09685971587896347,
-0.06978807598352432,
-0.028859231621026993,
-0.036940306425094604,
-0.17144864797592163,
-0.21498975157737732,
0.0050842901691794395,
0.010711219161748886,
-0.03850791975855827,
-0.06300245970487595,
0.033893097192049026,
-0.07714150100946426,
-0.027485840022563934,
0.3511793911457062,
0.04902252182364464,
0.015980172902345657,
-0.0022370691876858473,
-0.2524797320365906,
0.021102814003825188,
-0.16740049421787262,
-0.0071973251178860664,
0.22426845133304596,
-0.020498080179095268,
-0.34294381737709045,
0.18555410206317902,
0.08021365106105804,
0.2039087414741516,
-0.07994648069143295,
0.004619893617928028,
-0.055158887058496475,
0.03748713806271553,
0.16361261904239655,
-0.033741407096385956,
-0.21766884624958038,
0.02938164584338665,
-0.19752651453018188,
-0.022638076916337013,
0.08942140638828278,
0.25842875242233276,
0.016806088387966156,
0.08777891099452972,
-0.06855566799640656,
-0.19464708864688873,
-0.11742379516363144,
-0.0942864641547203,
0.22995392978191376,
0.09869910031557083,
0.17184613645076752,
-0.2034582495689392,
0.19951047003269196,
0.16020135581493378,
-0.0420636348426342,
0.053911421447992325,
0.014469865709543228,
-0.1368599385023117,
-0.019449541345238686,
0.06314259022474289,
-0.007579686585813761,
-0.006036471575498581,
-0.16962982714176178,
-0.05550474300980568,
0.02732519805431366,
-0.22895342111587524,
0.008860410191118717,
-0.11995694786310196,
0.09197010844945908,
-0.1382608562707901,
-0.20273955166339874,
-0.1311098039150238,
0.1990143358707428,
0.07167182117700577,
-0.02593972161412239,
0.023178717121481895,
-0.10948789119720459,
-0.1763804703950882,
0.057393576949834824,
0.16140811145305634,
-0.10385515540838242,
-0.09202058613300323,
0.024648239836096764,
-0.15853889286518097,
-0.34943172335624695,
-0.03765398636460304,
0.04038771614432335,
0.07400265336036682,
-0.14961059391498566,
-0.051600709557533264,
-0.0525088794529438,
0.11454875767230988,
0.13683700561523438,
-0.16440917551517487,
-0.02935199625790119,
0.10530803352594376,
-0.059783387929201126,
-0.12136790156364441,
-0.20000110566616058,
0.08656337112188339,
0.06527937948703766,
0.10111372172832489,
-0.1692522168159485,
0.2460491806268692,
-0.2059716284275055,
-0.15014253556728363,
0.04311135783791542,
0.09977278858423233,
0.2959349751472473,
-0.10834358632564545,
-0.16640102863311768,
-0.02164095640182495,
-0.11767120659351349,
0.07619542628526688,
-0.38948556780815125,
0.054374806582927704,
-0.12599942088127136,
0.015195774845778942,
0.01443149521946907,
0.17386291921138763,
-0.08151974529027939,
0.00046198678319342434,
-0.06831575185060501,
0.16247883439064026,
0.07145228981971741,
0.08099803328514099,
-0.24470309913158417,
0.2993820607662201,
0.12685741484165192,
0.027736369520425797,
-0.23224467039108276,
-0.04049365967512131,
0.26607561111450195,
-0.10938999056816101,
-0.16410592198371887,
0.15946651995182037,
-0.03150121122598648,
-0.10449117422103882,
0.05370160564780235,
0.04981408268213272,
-0.05901043117046356,
-0.1570732295513153,
-0.061973847448825836,
-0.1113571897149086,
0.05155491828918457,
0.015150683000683784,
-0.1713394820690155,
-0.23389002680778503,
0.1401575207710266,
-0.10871759802103043,
0.023071644827723503,
-0.21717160940170288,
0.13451531529426575,
-0.017327163368463516,
-0.24467463791370392,
-0.04767419770359993,
0.01868230290710926,
-0.0678553506731987,
0.16047847270965576,
-0.06994985789060593,
0.1718837469816208,
0.15737371146678925,
-0.04142586886882782,
0.1074223443865776,
-0.08895893394947052,
0.20484213531017303,
-0.15834781527519226,
-0.13129428029060364,
-0.04001195728778839,
0.06035863235592842,
0.027162151411175728,
-0.07830902934074402,
0.059955496340990067,
0.0647442564368248,
0.02482455223798752,
0.0442301481962204,
-0.37219539284706116,
-0.1463945508003235,
0.08771393448114395,
-0.0014669366646558046,
-0.04944145679473877,
0.012966413050889969,
-0.09722604602575302,
-0.008279424160718918,
0.0946877971291542,
-0.04195396602153778,
0.391804575920105,
-0.12808379530906677,
-0.3922668695449829,
-0.1351255476474762,
-0.24284538626670837,
0.0371614433825016,
0.1631256490945816,
-0.02966156043112278,
-0.041890084743499756,
0.05786838382482529,
-0.11404841393232346,
0.07490924745798111,
-0.15474702417850494,
0.2323664128780365,
0.26934322714805603,
0.002080918289721012,
-0.044267438352108,
0.38207778334617615,
-0.13819187879562378,
-0.2737082242965698,
-0.13473904132843018,
-0.037958983331918716,
-0.012547886930406094,
0.08152173459529877,
0.24342215061187744,
-0.20990175008773804,
-0.048192381858825684,
0.19991609454154968,
-0.10437794029712677,
-0.007789271418005228,
-0.06737923622131348,
-0.15160813927650452,
-0.13860982656478882,
0.03950922563672066,
0.22914716601371765,
-0.0763653814792633,
0.21579338610172272,
-0.1715235412120819,
0.16433840990066528,
0.04363056272268295,
-0.1794966608285904,
-0.0068696546368300915,
-0.01986163668334484,
-0.1448124647140503,
-0.15099577605724335,
-0.014347035437822342,
0.18201622366905212,
-0.13538821041584015,
0.05255838483572006,
0.28827178478240967,
0.017586108297109604,
-0.005838695447891951,
-0.18647363781929016,
-0.17071962356567383,
0.18855661153793335,
-0.09999591112136841,
0.17489276826381683,
0.13098303973674774,
0.11360203474760056,
-0.08663560450077057,
-0.16743938624858856,
-0.1280333250761032,
0.07813943177461624,
0.02091066539287567,
-0.008894294500350952,
-0.09848348796367645,
0.046986762434244156,
0.06787876784801483,
-0.1955050528049469,
-0.09746791422367096,
-0.08270013332366943,
0.03665853291749954,
0.09912232309579849,
0.02482920140028,
0.0946713238954544,
0.2049722969532013,
0.021204877644777298,
-0.1512775421142578,
-0.2273348867893219,
-0.06527230888605118,
-0.08168280124664307,
-0.02077338472008705,
-0.05555912107229233,
-0.1133008599281311,
0.19372722506523132,
-0.34243062138557434,
0.25233957171440125,
0.16178105771541595,
0.021394886076450348
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. otherwise healthy infants identified after newborn screening, sibs ascertained through evaluation prompted by diagnosis of the proband, and individuals with a diagnosis of PA with incomplete clinical characterization .Genotype-Phenotype CorrelationsAlthough precise genotype-phenotype correlations do not exist, some general comments related to molecular genetics are relevant.Null variants (PCCA: p.Arg313Ter, p.Ser562Ter; PCCB: p.Gly406fs, p.Gly94Ter, and out-of-frame small deletions/insertions, genomic abnormalities) result in loss-of-function alleles and are associated with a more severe form of PA .Homozygous missense pathogenic variants, in which partial enzymatic activity is retained (PCCA: p.Ala138Thr, p.Ile164Thr, p.Arg288Gly; PCCB: p.Asn536Asp) have been associated with a less severe phenotype.Some missense pathogenic variants (PCCB
p.Gly112A | [
0.03606749698519707,
0.02527415193617344,
-0.004994699731469154,
-0.1698022335767746,
0.2034359723329544,
-0.10032550245523453,
0.15019629895687103,
-0.24035097658634186,
-0.2452070713043213,
-0.14094866812229156,
0.2974996864795685,
0.09840786457061768,
0.006499068811535835,
0.014586739242076874,
-0.27843350172042847,
0.07720781862735748,
-0.0026056431233882904,
0.11039088666439056,
-0.048825763165950775,
-0.052502602338790894,
-0.13274507224559784,
-0.11370977759361267,
0.2213299423456192,
-0.033242832869291306,
0.19346675276756287,
-0.2825230360031128,
0.10546470433473587,
-0.3939119875431061,
0.0667627602815628,
0.05195295438170433,
0.15536372363567352,
-0.003028540639206767,
0.041815634816884995,
-0.2510664761066437,
-0.0025084184017032385,
-0.3548938035964966,
-0.07514134794473648,
0.004178598057478666,
0.16123650968074799,
-0.14494287967681885,
0.07686629891395569,
-0.2222924381494522,
0.3458231985569,
0.00547777721658349,
0.031608834862709045,
-0.038386449217796326,
0.0047217910178005695,
0.003274878254160285,
-0.01726974919438362,
0.21743740141391754,
0.05321214720606804,
-0.0713677629828453,
-0.06992003321647644,
-0.17862556874752045,
0.21752648055553436,
-0.070542111992836,
-0.004831130150705576,
0.006567911710590124,
-0.27762311697006226,
-0.016473054885864258,
0.033987417817115784,
0.11579973995685577,
-0.12248243391513824,
-0.1842196136713028,
0.3442763388156891,
-0.04325750097632408,
0.002393193542957306,
-0.0758327916264534,
0.03263555094599724,
-0.17757748067378998,
0.12413199990987778,
-0.1280556321144104,
0.061349108815193176,
0.07874264568090439,
-0.20138978958129883,
-0.003030996536836028,
0.18683204054832458,
0.1062723696231842,
0.1360197812318802,
-0.29836323857307434,
-0.10393065959215164,
-0.12843625247478485,
-0.03343807905912399,
0.0770641565322876,
-0.12504859268665314,
-0.12299928814172745,
0.3190215528011322,
-0.06556209921836853,
-0.04414782300591469,
0.12376841902732849,
0.007264322601258755,
-0.10948396474123001,
0.007811619434505701,
0.11393099278211594,
0.03904787823557854,
-0.2751200497150421,
-0.07513073086738586,
-0.05739399418234825,
-0.13100330531597137,
0.017702488228678703,
0.04781053960323334,
0.03644643723964691,
-0.08034221827983856,
0.03988667577505112,
-0.028364012017846107,
0.048121605068445206,
0.06504423916339874,
-0.049173109233379364,
-0.055536042898893356,
0.1414172649383545,
0.16819287836551666,
-0.13950887322425842,
0.15296049416065216,
0.04195472225546837,
-0.21001382172107697,
-0.002926196437329054,
-0.13134822249412537,
0.2667495310306549,
0.060979682952165604,
-0.02171727828681469,
0.11227726936340332,
0.12975730001926422,
-0.05768408998847008,
0.047515589743852615,
-0.11385218799114227,
0.025419000536203384,
0.12154754996299744,
0.14248335361480713,
0.13117671012878418,
-0.13535192608833313,
0.11066295206546783,
0.0628984272480011,
-0.16235391795635223,
-0.23302122950553894,
0.09003891050815582,
-0.18645969033241272,
-0.4375881850719452,
-0.3736574947834015,
-0.05485100299119949,
-0.08328310400247574,
0.08261818438768387,
0.0007845532963983715,
0.09292937815189362,
0.15234194695949554,
0.27200400829315186,
0.07405717670917511,
0.27603018283843994,
0.009073792025446892,
0.06582864373922348,
-0.02556893415749073,
-0.15012748539447784,
0.03542444482445717,
0.19101355969905853,
0.07065615803003311,
-0.15834181010723114,
-0.09523968398571014,
0.014168702065944672,
0.18888938426971436,
-0.35751450061798096,
0.1508716344833374,
0.12136957794427872,
0.06352552026510239,
-0.05465557426214218,
-0.041431933641433716,
0.20597165822982788,
0.00925963744521141,
-0.19545334577560425,
0.15794070065021515,
0.016230398789048195,
0.0006570850382559001,
-0.05864977091550827,
0.048798561096191406,
-0.05878235027194023,
0.20830950140953064,
0.035878345370292664,
0.05988295003771782,
-0.2713436484336853,
-0.12544123828411102,
0.029088011011481285,
0.02595685049891472,
0.11286681890487671,
-0.07198522984981537,
-0.28906717896461487,
-0.18229201436042786,
-0.0281609445810318,
-0.083262600004673,
0.14482788741588593,
0.2608705759048462,
-0.03548396751284599,
0.2780420780181885,
0.1803891807794571,
0.006442843936383724,
-0.07226074486970901,
-0.15924590826034546,
0.0710102990269661,
-0.23906899988651276,
0.12185847759246826,
0.06810994446277618,
-0.1792333722114563,
-0.0444655567407608,
0.021641159430146217,
0.017621058970689774,
-0.12680692970752716,
-0.0765056163072586,
-0.1102043017745018,
0.13136093318462372,
-0.07952604442834854,
0.004128108732402325,
-0.10466741025447845,
0.28659936785697937,
-0.012703493237495422,
0.15744081139564514,
-0.25676456093788147,
0.1588069498538971,
-0.24101664125919342,
-0.02684662491083145,
-0.042220234870910645,
-0.17591078579425812,
0.19247984886169434,
0.028085889294743538,
0.09649691730737686,
0.027117518708109856,
0.07769110798835754,
-0.2090788632631302,
0.09290970861911774,
0.08783766627311707,
-0.20256328582763672,
-0.12467040121555328,
0.06383189558982849,
-0.05226569622755051,
-0.07220598310232162,
-0.038512006402015686,
-0.005701443646103144,
0.055955223739147186,
-0.16971871256828308,
0.012007088400423527,
0.19483618438243866,
0.19090598821640015,
-0.025148408487439156,
0.025240477174520493,
-0.22440104186534882,
-0.0863829106092453,
0.07938456535339355,
-0.002440358279272914,
0.024994421750307083,
0.04149571806192398,
0.10061842948198318,
-0.04881606251001358,
-0.08522358536720276,
0.08562041074037552,
-0.05367595702409744,
-0.004983811639249325,
0.008218271657824516,
-0.011890364810824394,
-0.47645267844200134,
0.08221931755542755,
0.007409167010337114,
0.09765251725912094,
0.11862875521183014,
0.16076183319091797,
0.09133733063936234,
0.10284843295812607,
-0.00929737277328968,
0.1669004261493683,
-0.05384847894310951,
0.08594193309545517,
-0.16772215068340302,
0.08277516812086105,
-0.027364762499928474,
-0.23075854778289795,
-0.06611957401037216,
0.16171589493751526,
-0.045930083841085434,
0.14161688089370728,
-0.18762989342212677,
-0.07539151608943939,
0.13364644348621368,
0.06469369679689407,
-0.0036949857603758574,
0.17711663246154785,
-0.08837282657623291,
0.01950410194694996,
-0.18614448606967926,
0.14765508472919464,
0.2303750067949295,
-0.05474492534995079,
0.11283591389656067,
0.08251188695430756,
0.07410601526498795,
0.11668235808610916,
-0.016838543117046356,
0.14681337773799896,
0.010628500021994114,
0.033728841692209244,
0.09248372912406921,
0.2521572709083557,
0.0013741647126153111,
-0.05450017377734184,
-0.027904758229851723,
0.12348407506942749,
0.08750174194574356,
-0.10348881036043167,
0.008799456991255283,
-0.13832595944404602,
-0.16302163898944855,
0.013388039544224739,
-0.13825543224811554,
0.05494948476552963,
0.042714182287454605,
0.20178835093975067,
-0.1677340418100357,
-0.23385502398014069,
-0.21369576454162598,
0.09097851812839508,
0.04211229085922241,
0.10133197903633118,
0.0359334796667099,
0.1725400686264038,
0.20101940631866455,
0.19627995789051056,
0.02371041290462017,
-0.0071825203485786915,
0.16573210060596466,
0.17471158504486084,
-0.2900526225566864,
0.047806087881326675,
-0.2619718611240387,
-0.0006700754747726023,
-0.06929006427526474,
0.09877340495586395,
-0.03382103890180588,
0.02322942204773426,
0.16828033328056335,
-0.040190309286117554,
0.20822983980178833,
0.08928915858268738,
0.3825438618659973,
-0.04993284121155739,
-0.06327363848686218,
0.17233601212501526,
0.08974092453718185,
-0.25953593850135803,
-0.17088843882083893,
0.04789116978645325,
-0.14815185964107513,
0.14374826848506927,
-0.03463239222764969,
-0.020684273913502693,
0.14684833586215973,
-0.17022119462490082,
-0.029411420226097107,
-0.009932068176567554,
-0.16868481040000916,
-0.09102194011211395,
0.20780301094055176,
-0.05117211490869522,
-0.05074143409729004,
0.1152837723493576,
0.19653011858463287,
0.026567893102765083,
-0.17763730883598328,
-0.016062602400779724,
0.1199251189827919,
-0.036215800791978836,
0.08509042114019394,
-0.2716672420501709,
0.08991048485040665,
0.0948265865445137,
0.1124856173992157,
0.029636200517416,
0.16537758708000183,
0.3316245377063751,
0.13724224269390106,
0.19321008026599884,
0.02789388597011566,
0.2783593535423279,
-0.2827877402305603,
0.03909345716238022,
-0.24156540632247925,
-0.013572639785706997,
0.12528395652770996,
0.011547403410077095,
0.10164239257574081,
-0.09473046660423279,
0.13066178560256958,
-0.014220373705029488,
-0.09565246105194092,
0.07186813652515411,
0.18768689036369324,
-0.246072918176651,
-0.07943074405193329,
0.1704597920179367,
0.08300319314002991,
0.02726914919912815,
-0.07554540038108826,
0.1377004086971283,
-0.13588596880435944,
-0.07259827107191086,
-0.062065158039331436,
0.08957099914550781,
-0.1609094738960266,
-0.0657544732093811,
0.03003619611263275,
0.237926185131073,
0.03251545503735542,
0.0973895788192749,
0.014745688997209072,
0.06457465887069702,
0.011291458271443844,
0.11177527904510498,
-0.03580092266201973,
0.015637746080756187,
-0.07108814269304276,
-0.10084713995456696,
-0.1211077943444252,
-0.060176730155944824,
0.018610671162605286,
-0.018891552463173866,
0.09177093207836151,
-0.08462923020124435,
-0.04648122936487198,
0.07620804756879807,
0.018436249345541,
-0.09121118485927582,
-0.15012282133102417,
-0.08682451397180557,
0.14842921495437622,
-0.012927847914397717,
0.005948903504759073,
0.02843087539076805,
-0.037596214562654495,
-0.029061587527394295,
-0.026983650401234627,
-0.027609247714281082,
0.08385845273733139,
-0.003596983850002289,
0.15943267941474915,
-0.03482278436422348,
0.098587267100811,
0.03165437653660774,
0.05347723141312599,
0.27074065804481506,
-0.12095910310745239,
-0.005272991489619017,
-0.1414225846529007,
0.16984795033931732,
0.32748520374298096,
0.1357635110616684,
-0.009083623997867107,
0.15883925557136536,
0.10435312986373901,
-0.17415860295295715,
-0.17682626843452454,
-0.051094889640808105,
-0.06208678334951401,
0.09986662864685059,
0.048159223049879074,
-0.29838940501213074,
-0.03957611322402954,
-0.045550547540187836,
-0.21437612175941467,
0.09023342281579971,
0.028959481045603752,
-0.12466486543416977,
-0.01656966283917427,
-0.030550390481948853,
0.06952317804098129,
0.10084305703639984,
0.20944084227085114,
-0.034386154264211655,
0.32017582654953003,
0.11798349767923355,
-0.16374900937080383,
-0.10109985619783401,
-0.15189309418201447,
0.003611210733652115,
0.023209383711218834,
-0.156893789768219,
-0.10989338904619217,
0.043812379240989685,
0.09790179133415222,
-0.09421460330486298,
0.03530861809849739,
-0.23365375399589539,
-0.019443687051534653,
0.15881021320819855,
-0.10708215087652206,
-0.11573148518800735,
0.04500461742281914,
0.04555666074156761,
-0.1419774442911148,
0.17198282480239868,
0.24733425676822662,
0.3715309202671051,
-0.06502822041511536,
-0.11036382615566254,
-0.09249173104763031,
-0.08378026634454727,
0.009620888158679008,
-0.09320104122161865,
-0.18484503030776978,
-0.026026181876659393,
-0.029819762334227562,
0.17200475931167603,
-0.1036657765507698,
-0.11922910809516907,
0.03697257488965988,
-0.22250710427761078,
0.13332833349704742,
0.24813470244407654,
-0.19933073222637177,
-0.05385049432516098,
0.04894113913178444,
-0.1396624892950058,
-0.050479706376791,
-0.19949392974376678,
0.057091765105724335,
0.04722108691930771,
0.08602792024612427,
-0.2074306160211563,
0.17394450306892395,
-0.17319819331169128,
0.335156112909317,
-0.14430268108844757,
-0.0585884265601635,
-0.12989182770252228,
-0.01897806115448475,
0.19925498962402344,
-0.06849990785121918,
-0.2537744343280792,
-0.04798064008355141,
0.02267962507903576,
-0.17051246762275696,
0.19700531661510468,
0.004482885356992483,
0.10556748509407043,
0.030127236619591713,
0.009890076704323292,
-0.24048995971679688,
-0.07624312490224838,
-0.014034944586455822,
0.06645046919584274,
-0.03230711817741394,
-0.04041918367147446,
-0.16281604766845703,
0.12779006361961365,
0.09325135499238968,
0.051617950201034546,
0.3019868731498718,
-0.05600858852267265,
-0.12013814598321915,
-0.0323200523853302,
0.010258478112518787,
-0.22758397459983826,
-0.1208641305565834,
-0.029876969754695892,
-0.053081490099430084,
-0.07372944056987762,
-0.17066390812397003,
0.07738281786441803,
-0.2576601803302765,
0.15973670780658722,
-0.19009633362293243,
-0.04354409500956535,
-0.04056849330663681,
0.26300469040870667,
0.028350073844194412,
-0.057094328105449677,
-0.05420103296637535,
-0.11337566375732422,
-0.15187616646289825,
0.034298308193683624,
0.14256168901920319,
0.09675843268632889,
-0.003418880980461836,
0.009396755136549473,
-0.08438453823328018,
-0.37945544719696045,
-0.23393167555332184,
-0.0004011520941276103,
-0.03341567888855934,
-0.17829233407974243,
0.03915075957775116,
-0.13779906928539276,
0.04088965058326721,
0.08313680440187454,
-0.06651389598846436,
-0.12018195539712906,
0.1957283616065979,
-0.10833685100078583,
-0.043979279696941376,
-0.07751612365245819,
0.008322183042764664,
-0.012903956696391106,
-0.028164535760879517,
-0.1003064215183258,
0.31570351123809814,
-0.10185416787862778,
-0.13507157564163208,
0.006067935843020678,
0.02887229435145855,
0.24975702166557312,
0.061932437121868134,
-0.20425660908222198,
0.14086630940437317,
0.0053865606896579266,
0.1944480836391449,
-0.37649884819984436,
-0.04653239622712135,
-0.012831666506826878,
-0.003114663530141115,
-0.01377168856561184,
0.05159144848585129,
-0.09784437716007233,
0.11401285976171494,
-0.01590297371149063,
0.1999335139989853,
0.17983096837997437,
0.1014186441898346,
-0.12038841843605042,
0.22502052783966064,
0.0717572271823883,
-0.0612737312912941,
-0.29099589586257935,
-0.03093276359140873,
0.10087710618972778,
-0.02250758558511734,
-0.08733115345239639,
0.09023475646972656,
-0.08958713710308075,
-0.039035532623529434,
-0.13017860054969788,
-0.03838265687227249,
0.2219303399324417,
-0.16780158877372742,
0.1614537090063095,
-0.2521887719631195,
0.15947596728801727,
0.10390939563512802,
-0.029894715175032616,
-0.03548796847462654,
0.13093586266040802,
-0.04713023453950882,
0.17372259497642517,
-0.19944320619106293,
0.22667188942432404,
-0.13956087827682495,
-0.10031160712242126,
0.12634922564029694,
0.005063369870185852,
0.03591792285442352,
0.14705820381641388,
-0.21866543591022491,
0.3593727946281433,
0.08658437430858612,
-0.2123747617006302,
0.027165647596120834,
-0.05955949053168297,
0.12128724157810211,
-0.1758059710264206,
0.02604956366121769,
-0.026189137250185013,
-0.019588138908147812,
-0.08320900797843933,
-0.00881185568869114,
0.060133274644613266,
0.09046217054128647,
0.02970588393509388,
0.1114414855837822,
-0.33557507395744324,
0.016207944601774216,
0.06664259731769562,
0.06850706785917282,
-0.03221939504146576,
0.15342707931995392,
-0.07627216726541519,
-0.0310478825122118,
0.11474903672933578,
-0.07585632055997849,
0.3404184579849243,
-0.17282071709632874,
-0.3650580048561096,
-0.14957252144813538,
0.02111964300274849,
0.08609416335821152,
0.18426324427127838,
0.044416408985853195,
0.0965006873011589,
0.036962322890758514,
-0.22848686575889587,
-0.025013428181409836,
-0.07168947160243988,
-0.010674227960407734,
0.26026177406311035,
0.020687073469161987,
0.003410142846405506,
0.34970623254776,
-0.008341710083186626,
-0.2681528925895691,
-0.02921115979552269,
-0.16065223515033722,
-0.08964109420776367,
0.021855240687727928,
0.18346786499023438,
-0.10170801728963852,
-0.13528810441493988,
0.18554219603538513,
-0.11992403119802475,
-0.07104486972093582,
0.09852677583694458,
-0.08253178000450134,
-0.09055067598819733,
0.1006498783826828,
0.1588878482580185,
-0.07767944037914276,
-0.033365774899721146,
-0.09211842715740204,
0.06317314505577087,
-0.06498711556196213,
-0.13326238095760345,
0.06022763252258301,
-0.004958367440849543,
-0.04890649765729904,
-0.13213905692100525,
-0.11611825972795486,
0.2903035879135132,
-0.06498059630393982,
0.17597004771232605,
0.15169207751750946,
-0.043291445821523666,
0.012917296029627323,
0.05874873325228691,
-0.3495649993419647,
0.05778495967388153,
-0.10644380003213882,
0.17503921687602997,
0.025439245626330376,
-0.016520680859684944,
-0.007507411763072014,
-0.21025986969470978,
0.08273767679929733,
0.08248724043369293,
-0.11526702344417572,
-0.20852778851985931,
0.020107615739107132,
0.14072419703006744,
0.022703805938363075,
-0.06227795407176018,
-0.10289134085178375,
-0.060753852128982544,
0.2004423886537552,
0.23263324797153473,
0.03889412805438042,
-0.14523476362228394,
0.21705448627471924,
-0.03182131424546242,
-0.04482502117753029,
-0.04494906961917877,
0.07808269560337067,
-0.0905686467885971,
-0.11380693316459656,
-0.04995734617114067,
0.05984310433268547,
-0.05927440896630287,
-0.1673511117696762,
0.22774635255336761,
-0.04337482154369354,
-0.06782770901918411
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. out-of-frame small deletions/insertions, genomic abnormalities) result in loss-of-function alleles and are associated with a more severe form of PA .Homozygous missense pathogenic variants, in which partial enzymatic activity is retained (PCCA: p.Ala138Thr, p.Ile164Thr, p.Arg288Gly; PCCB: p.Asn536Asp) have been associated with a less severe phenotype.Some missense pathogenic variants (PCCB
p.Gly112Asp, p.Arg512Cys, and p.Leu519Pro) which affect heterododecamer formation can result in undetectable PCC enzyme activity and severe phenotype .A homozygous PCCB variant in Amish and Mennonite populations, p.Asn536Asp, is associated with high residual PCC activity. It confers a lower risk of developing metabolic crisis, but can lead to late-onset cardiomyopathy.A homozygous PCCB variant, p.Tyr43 | [
0.03322778269648552,
0.06531256437301636,
-0.07765673846006393,
-0.21609851717948914,
0.08418910205364227,
-0.09086200594902039,
0.08784113824367523,
-0.16883856058120728,
-0.11024486273527145,
-0.09161555022001266,
0.22235430777072906,
0.03656771406531334,
-0.03794058412313461,
0.03587263077497482,
-0.2945166230201721,
0.1482425481081009,
-0.05905464291572571,
0.2368718683719635,
-0.05166810378432274,
-0.11950375139713287,
-0.03234468027949333,
-0.24098274111747742,
0.1365799903869629,
-0.007898435927927494,
0.1777423620223999,
-0.2646559774875641,
0.13399803638458252,
-0.3208000659942627,
0.05514847859740257,
0.04963389039039612,
0.16313478350639343,
0.04130328446626663,
0.05547651648521423,
-0.22873277962207794,
-0.01168061699718237,
-0.2602609694004059,
-0.11043144762516022,
-0.1107167899608612,
0.08230084180831909,
-0.16662487387657166,
0.1215166300535202,
-0.2141726016998291,
0.3106696605682373,
0.00545844342559576,
0.0731436163187027,
0.008220168761909008,
-0.007665716111660004,
-0.09664406627416611,
0.012788420543074608,
0.19816462695598602,
0.10161754488945007,
-0.10308816283941269,
-0.07388810813426971,
-0.20439496636390686,
0.2498624473810196,
-0.04311508685350418,
-0.018781861290335655,
-0.004678230732679367,
-0.2924136519432068,
0.06215173378586769,
0.04128987342119217,
0.037000179290771484,
-0.0686294436454773,
-0.2598542273044586,
0.2229347825050354,
-0.08244016766548157,
-0.039593327790498734,
-0.04507678002119064,
0.14876572787761688,
-0.08549994975328445,
0.1675204038619995,
-0.1859443336725235,
0.09378300607204437,
0.11629974097013474,
-0.09340518712997437,
0.01761128194630146,
0.1415676772594452,
0.10067009925842285,
-0.016654126346111298,
-0.2674925923347473,
-0.159689798951149,
-0.07247556000947952,
-0.02864447608590126,
0.11127912253141403,
-0.19590912759304047,
-0.11651796847581863,
0.29685795307159424,
-0.025871876627206802,
-0.05378703027963638,
0.1265987902879715,
0.05092144012451172,
-0.08216524869203568,
-0.056762684136629105,
0.031244173645973206,
0.07228098809719086,
-0.14587074518203735,
0.02711550146341324,
0.02926667407155037,
-0.1760147660970688,
-0.027518820017576218,
0.01576181873679161,
-0.09029039740562439,
-0.11343785375356674,
0.10232087969779968,
0.03490278497338295,
0.05009486526250839,
-0.030489617958664894,
-0.002074669348075986,
-0.03178424760699272,
0.15117250382900238,
0.09006329625844955,
-0.22301991283893585,
0.0575629286468029,
0.05455809831619263,
-0.1754811555147171,
-0.018840564414858818,
-0.06079862639307976,
0.24280737340450287,
0.05476103350520134,
0.049013491719961166,
0.1422083079814911,
0.07753225415945053,
-0.024979660287499428,
-0.05088837444782257,
-0.13317067921161652,
0.0471682995557785,
0.08728884160518646,
0.10684403032064438,
0.1635030210018158,
-0.02107820101082325,
0.125650092959404,
0.03954566270112991,
-0.03705284371972084,
-0.19113880395889282,
0.1298876851797104,
-0.20623044669628143,
-0.3954602777957916,
-0.3667497932910919,
-0.061321765184402466,
0.003123808652162552,
-0.0062182568944990635,
0.03539380058646202,
0.10748527944087982,
0.14805668592453003,
0.22460144758224487,
0.032549262046813965,
0.35173308849334717,
-0.043176811188459396,
0.1566474735736847,
-0.044326044619083405,
-0.053647588938474655,
-0.12002146244049072,
0.20005646347999573,
0.03973252326250076,
-0.15241940319538116,
-0.03742251172661781,
0.03218269720673561,
0.19402368366718292,
-0.2482651323080063,
0.059010475873947144,
0.07144253700971603,
0.10435282438993454,
-0.0011196009581908584,
-0.051111720502376556,
0.16365717351436615,
-0.015018891543149948,
-0.1695951521396637,
0.05949636176228523,
0.02338452823460102,
-0.03790964186191559,
-0.10469196736812592,
0.04728512838482857,
-0.04209477826952934,
0.13477252423763275,
0.08713947236537933,
0.07968799024820328,
-0.20414239168167114,
-0.047716110944747925,
0.0052275038324296474,
-0.032588373869657516,
0.09003296494483948,
-0.08443894982337952,
-0.3222637176513672,
-0.23870019614696503,
-0.08776235580444336,
-0.09113698452711105,
0.14415502548217773,
0.2902710437774658,
-0.10862753540277481,
0.2762376666069031,
0.1417219340801239,
0.04140709340572357,
-0.10722827166318893,
-0.06255503743886948,
0.02983684465289116,
-0.2609597444534302,
0.1270897090435028,
-0.003162299981340766,
-0.14253228902816772,
-0.06953886896371841,
-0.019349398091435432,
0.014322458766400814,
-0.04719962924718857,
-0.0876142755150795,
-0.04405516758561134,
0.08279899507761002,
-0.08750345557928085,
-0.01893506944179535,
-0.07411004602909088,
0.22079351544380188,
0.005479793529957533,
0.17351604998111725,
-0.20838959515094757,
0.09332560002803802,
-0.14646123349666595,
-0.06527084112167358,
0.025647956877946854,
-0.06019134819507599,
0.2220994383096695,
0.03346320614218712,
0.08273392915725708,
-0.012269625440239906,
0.1217682734131813,
-0.26189494132995605,
-0.03357422724366188,
0.0006969221867620945,
-0.20635655522346497,
-0.1724124550819397,
0.07490415126085281,
-0.06822902709245682,
-0.03541666641831398,
-0.017836421728134155,
-0.04655851051211357,
-0.04409113526344299,
-0.1004054844379425,
-0.028937997296452522,
0.07329989224672318,
0.14892439544200897,
-0.07613055408000946,
-0.09489193558692932,
-0.2781596779823303,
-0.03324282169342041,
0.04326308146119118,
-0.025997977703809738,
0.019688062369823456,
-0.027596963569521904,
0.07068111002445221,
0.06538055837154388,
-0.11471439152956009,
0.09087829291820526,
-0.01595110073685646,
0.01357246097177267,
-0.026870282366871834,
0.017456935718655586,
-0.46513015031814575,
-0.023275014013051987,
0.07256674021482468,
0.11690974980592728,
0.10459541529417038,
0.10114748775959015,
-0.03640759363770485,
0.10371425747871399,
-0.042865950614213943,
0.15618731081485748,
-0.07559733837842941,
0.029612187296152115,
-0.18960176408290863,
0.037144143134355545,
-0.04963791370391846,
-0.25829818844795227,
-0.08961573243141174,
0.16001346707344055,
0.06815788149833679,
0.07243507355451584,
-0.27614694833755493,
-0.19975659251213074,
0.1230640634894371,
0.04869471862912178,
0.11105406284332275,
0.18664538860321045,
-0.12153411656618118,
0.04211607947945595,
-0.16507165133953094,
0.11946149170398712,
0.2878100872039795,
-0.14051154255867004,
0.062130969017744064,
-0.0003304499259684235,
0.052767638117074966,
0.1980973482131958,
-0.0841301754117012,
0.2089756578207016,
-0.021073687821626663,
0.07804859429597855,
0.0752313956618309,
0.1777050495147705,
0.012595259584486485,
-0.07031580805778503,
0.036615267395973206,
0.05979149043560028,
0.1479537934064865,
0.02366710640490055,
0.11759063601493835,
-0.052207931876182556,
-0.0903276652097702,
-0.00765699939802289,
0.006038443651050329,
0.07547471672296524,
0.11002248525619507,
0.2298612743616104,
-0.2423146516084671,
-0.1452673375606537,
-0.2709004580974579,
0.05601976066827774,
0.028120530769228935,
0.07824363559484482,
0.10531184822320938,
0.09382960945367813,
0.22748760879039764,
0.2090454399585724,
-0.007487796247005463,
0.03028133511543274,
0.05824943631887436,
0.13268014788627625,
-0.26295801997184753,
0.11320898681879044,
-0.1770631968975067,
0.025821348652243614,
-0.07346979528665543,
0.12220926582813263,
0.015864649787545204,
0.12229211628437042,
0.08088023215532303,
-0.07773378491401672,
0.16666725277900696,
0.047498919069767,
0.32826849818229675,
0.026849469169974327,
-0.043860144913196564,
0.12407541275024414,
0.13525725901126862,
-0.2432297319173813,
-0.15191249549388885,
-0.04465392604470253,
-0.22224654257297516,
0.181099072098732,
-0.06659792363643646,
-0.028327910229563713,
0.06876233220100403,
-0.12420987337827682,
-0.07790539413690567,
-0.029966114088892937,
-0.11112481355667114,
-0.03027474693953991,
0.2763153910636902,
-0.20817045867443085,
-0.04626128822565079,
0.06285655498504639,
0.21285925805568695,
0.13030852377414703,
-0.21831072866916656,
0.0666922852396965,
0.09420037269592285,
0.020340923219919205,
0.11441433429718018,
-0.24435819685459137,
0.04692777618765831,
0.111676424741745,
0.10063484311103821,
0.04340009018778801,
0.16677486896514893,
0.18967950344085693,
0.14337791502475739,
0.27189478278160095,
-0.055903080850839615,
0.2597537338733673,
-0.20198999345302582,
0.02594708651304245,
-0.20679661631584167,
-0.0003919809532817453,
0.14802668988704681,
0.03391764685511589,
0.1733293980360031,
-0.06342168152332306,
-0.01540105976164341,
-0.017345760017633438,
-0.07736504822969437,
0.015301470644772053,
0.2035152018070221,
-0.3673763871192932,
-0.033216897398233414,
0.12843196094036102,
0.06025036424398422,
0.043204937130212784,
-0.07721232622861862,
0.19411130249500275,
-0.018104538321495056,
-0.0486091673374176,
-0.1517990529537201,
0.01932828687131405,
-0.16621951758861542,
-0.07919872552156448,
0.11703052371740341,
0.1921238899230957,
0.08306419104337692,
0.09487006068229675,
0.025294044986367226,
0.12235074490308762,
-0.04402009770274162,
0.14908063411712646,
-0.0025100717321038246,
-0.0010733810486271977,
0.019570985808968544,
-0.15228627622127533,
-0.1795562207698822,
-0.08488277345895767,
0.13611775636672974,
-0.0037270071916282177,
0.08628355711698532,
-0.09176180511713028,
-0.05067969858646393,
0.12948384881019592,
0.04993214085698128,
-0.09455492347478867,
-0.21024678647518158,
-0.06988739222288132,
0.11894334107637405,
-0.0071317339316010475,
0.12427978217601776,
0.013074594549834728,
0.07833530008792877,
0.024493727833032608,
-0.13837212324142456,
-0.05658804997801781,
0.0744255930185318,
0.06682827323675156,
0.12261752039194107,
0.08324393630027771,
0.04449797794222832,
-0.03664303570985794,
0.05569574981927872,
0.29259181022644043,
-0.09001363813877106,
-0.032542090862989426,
-0.11579087376594543,
0.20617491006851196,
0.2599136233329773,
0.09308624267578125,
-0.032170865684747696,
0.12753823399543762,
0.06960178166627884,
-0.13394826650619507,
-0.1497182846069336,
-0.06256058812141418,
-0.05656862631440163,
0.10900822281837463,
0.1438027024269104,
-0.19680096209049225,
0.0021664004307240248,
-0.010403154417872429,
-0.17991942167282104,
0.1130664274096489,
0.15294325351715088,
-0.07153279334306717,
-0.061964135617017746,
0.015951339155435562,
-0.029621191322803497,
0.14564307034015656,
0.13473764061927795,
0.06369912624359131,
0.23561231791973114,
0.0820867121219635,
-0.17659154534339905,
-0.07583003491163254,
-0.1531379222869873,
-0.09569195657968521,
-0.006159757263958454,
-0.22720418870449066,
-0.039857491850852966,
-0.02280401438474655,
0.05895889922976494,
-0.15085577964782715,
0.05368029698729515,
-0.18996034562587738,
-0.01584181934595108,
0.10545778274536133,
-0.10248018801212311,
-0.03376145660877228,
0.1686781942844391,
0.08259502053260803,
0.0051782694645226,
0.09935179352760315,
0.21136844158172607,
0.4136701226234436,
-0.16318528354167938,
-0.18610480427742004,
0.000039696420571999624,
-0.12171584367752075,
-0.029347626492381096,
-0.07557397335767746,
-0.1636977344751358,
0.012909761629998684,
-0.03485016152262688,
0.1392507553100586,
-0.07254708558320999,
-0.10031485557556152,
-0.06076352670788765,
-0.23518776893615723,
0.09583285450935364,
0.26584315299987793,
-0.14194615185260773,
0.012661175802350044,
0.03822437673807144,
-0.11832849681377411,
-0.04783889651298523,
-0.194834902882576,
0.07909928262233734,
0.10084536671638489,
0.14817319810390472,
-0.2464466691017151,
0.14750440418720245,
-0.20107705891132355,
0.27030476927757263,
-0.12222668528556824,
0.021732909604907036,
-0.048288796097040176,
0.01122159045189619,
0.18179894983768463,
-0.0812273696064949,
-0.21420112252235413,
-0.04580151289701462,
-0.011587622575461864,
-0.16925707459449768,
0.16999152302742004,
0.10986077785491943,
0.028315739706158638,
0.04801302030682564,
-0.024002715945243835,
-0.1475433111190796,
-0.08689083158969879,
-0.018170129507780075,
0.007673528045415878,
-0.0432896688580513,
-0.037438031286001205,
-0.15821871161460876,
0.07348141819238663,
0.13354094326496124,
0.10537929832935333,
0.23358066380023956,
-0.04376824200153351,
-0.11749255657196045,
-0.09831253439188004,
-0.08080726861953735,
-0.17725954949855804,
-0.09685714542865753,
0.0021433858200907707,
-0.053095582872629166,
-0.15015842020511627,
-0.07212715595960617,
0.05056218057870865,
-0.12351685762405396,
0.01514877937734127,
-0.25645872950553894,
-0.03968511149287224,
-0.020755456760525703,
0.1876392513513565,
0.06450899690389633,
-0.10920783877372742,
-0.008917597122490406,
-0.1706061065196991,
-0.12094816565513611,
0.09904193878173828,
0.1968839019536972,
0.04072387143969536,
-0.09778399765491486,
0.01632969081401825,
-0.1636601686477661,
-0.3467220067977905,
-0.15141986310482025,
0.0066520050168037415,
0.022966185584664345,
-0.17301280796527863,
0.06993342190980911,
-0.23180943727493286,
0.04857248440384865,
0.06166090816259384,
-0.05442745238542557,
-0.03489265218377113,
0.14722758531570435,
-0.07750299572944641,
-0.07083451747894287,
-0.13550344109535217,
0.021624447777867317,
-0.08962653577327728,
0.05852292850613594,
-0.14058628678321838,
0.23001153767108917,
-0.17074579000473022,
-0.07059238851070404,
-0.00521662225946784,
0.01794135570526123,
0.24291187524795532,
0.019489508122205734,
-0.2099480777978897,
0.0713406428694725,
-0.012822600081562996,
0.20345735549926758,
-0.3437114953994751,
-0.053213465958833694,
-0.028559574857354164,
0.014585440047085285,
0.05275062471628189,
0.050473056733608246,
-0.08885102719068527,
0.06668046861886978,
-0.02562602423131466,
0.1769530475139618,
0.053541816771030426,
0.12274856120347977,
-0.08323584496974945,
0.2368791699409485,
0.16669927537441254,
-0.06701795756816864,
-0.2102116197347641,
-0.07587668299674988,
0.11783323436975479,
0.01250408124178648,
-0.11167760193347931,
0.12162045389413834,
-0.1658305674791336,
-0.12770387530326843,
0.004901606123894453,
0.031762413680553436,
0.16998586058616638,
-0.19332042336463928,
0.08977508544921875,
-0.1503196656703949,
0.16256563365459442,
-0.023368222638964653,
-0.11001665890216827,
-0.15780757367610931,
0.10577019304037094,
-0.19086088240146637,
0.2067730873823166,
-0.24247422814369202,
0.21097950637340546,
-0.14475703239440918,
-0.09248366951942444,
0.15782430768013,
0.03887233883142471,
0.0750703290104866,
0.0438842810690403,
-0.15496547520160675,
0.3914918601512909,
0.16940520703792572,
-0.16778424382209778,
0.002930621150881052,
0.014312737621366978,
0.2571522891521454,
-0.17688967287540436,
0.012459620833396912,
-0.035800639539957047,
0.00990331545472145,
-0.07760346680879593,
-0.03677617758512497,
0.052478086203336716,
0.05609893053770065,
-0.01930234208703041,
0.14711900055408478,
-0.2845122516155243,
-0.11966466903686523,
0.04745760187506676,
-0.005640167277306318,
0.044116415083408356,
0.12275540828704834,
-0.057904671877622604,
-0.10319102555513382,
0.17183098196983337,
-0.08437560498714447,
0.32933855056762695,
-0.1322391778230667,
-0.33334267139434814,
-0.08455053716897964,
0.03256508335471153,
0.19046056270599365,
0.0846581757068634,
0.03112197481095791,
0.025599434971809387,
0.011076334863901138,
-0.2365466058254242,
-0.07265143096446991,
-0.15457309782505035,
-0.012116167694330215,
0.28580427169799805,
-0.0703522115945816,
0.0049442690797150135,
0.26593443751335144,
-0.10233079642057419,
-0.2991098463535309,
-0.03957178071141243,
-0.21539835631847382,
-0.031129369512200356,
0.10007587820291519,
0.270540326833725,
-0.16352009773254395,
-0.15935683250427246,
0.1482636034488678,
-0.0965714380145073,
-0.06140745431184769,
0.05556263029575348,
-0.08521310985088348,
-0.15475063025951385,
0.05905639007687569,
0.12036342918872833,
-0.07971398532390594,
0.06890619546175003,
-0.054646868258714676,
0.055321838706731796,
-0.05807080119848251,
-0.192657470703125,
-0.005179436877369881,
0.027978790923953056,
0.068349689245224,
-0.0672750174999237,
-0.07440124452114105,
0.16668497025966644,
0.021714752539992332,
0.07096459716558456,
0.16792061924934387,
-0.027417095378041267,
0.012779566459357738,
-0.04667997360229492,
-0.3155410885810852,
0.11259912699460983,
-0.22293269634246826,
0.08040574938058853,
0.04390234500169754,
0.018279947340488434,
0.06747230887413025,
-0.09814178943634033,
-0.048107996582984924,
0.11935555189847946,
-0.055724285542964935,
-0.19085277616977692,
0.05266589671373367,
0.19449737668037415,
0.021017353981733322,
-0.04006956145167351,
-0.1509135216474533,
-0.07084900885820389,
0.1790001541376114,
0.23220936954021454,
0.09458686411380768,
-0.0579800009727478,
0.2595052123069763,
0.04260958731174469,
-0.09573043882846832,
-0.10946755856275558,
0.08100571483373642,
-0.06669344753026962,
-0.11856116354465485,
-0.12983167171478271,
0.036818571388721466,
0.0429193377494812,
-0.25542595982551575,
0.1556677669286728,
-0.0034031295217573643,
-0.02346968650817871
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. B
p.Gly112Asp, p.Arg512Cys, and p.Leu519Pro) which affect heterododecamer formation can result in undetectable PCC enzyme activity and severe phenotype .A homozygous PCCB variant in Amish and Mennonite populations, p.Asn536Asp, is associated with high residual PCC activity. It confers a lower risk of developing metabolic crisis, but can lead to late-onset cardiomyopathy.A homozygous PCCB variant, p.Tyr435Cys, has been detected in apparently asymptomatic or mildly affected children identified through newborn screening in Japan .NomenclaturePropionic acidemia and propionyl-CoA carboxylase deficiency are the two most common terms used to describe the condition. Ketotic hyperglycinemia was used in the 1960s before defects in propionyl-CoA carboxylase were determined to be the underlying cause of PA . The term propionic aciduria is used infrequently.PrevalenceWorldwide, the incidence of PA varies widely. | [
-0.05706005543470383,
0.07313556969165802,
-0.06383693218231201,
-0.3174155056476593,
0.2667250633239746,
-0.09101316332817078,
0.07534590363502502,
-0.2724337577819824,
0.13371644914150238,
-0.2014012485742569,
0.2147892415523529,
0.037858232855796814,
0.019083762541413307,
0.07684288173913956,
-0.2940770387649536,
0.235956609249115,
0.12174555659294128,
0.004640566185116768,
-0.0298629030585289,
-0.17859894037246704,
-0.08006399869918823,
-0.2906723618507385,
0.09177549183368683,
0.06105054169893265,
0.2110927700996399,
-0.02721577137708664,
0.2336222529411316,
-0.416940838098526,
0.23923711478710175,
0.05711659789085388,
0.12503187358379364,
0.014842958189547062,
0.17275318503379822,
-0.3374830186367035,
-0.02593730390071869,
-0.242947518825531,
-0.06870587170124054,
-0.20637895166873932,
-0.005338234361261129,
-0.2751316428184509,
0.2182464897632599,
-0.0981350839138031,
0.29258453845977783,
-0.10692372173070908,
0.18640345335006714,
0.050946373492479324,
-0.09215635061264038,
-0.112504743039608,
0.027156425639986992,
0.2552087903022766,
0.29683151841163635,
-0.17432750761508942,
-0.117449551820755,
-0.16455329954624176,
0.23095665872097015,
-0.035330843180418015,
-0.12439259886741638,
-0.07789589464664459,
-0.20628835260868073,
0.1469547301530838,
0.15888042747974396,
-0.051937658339738846,
-0.21021509170532227,
-0.21557840704917908,
0.18394365906715393,
-0.11152239888906479,
-0.012573683634400368,
0.16613434255123138,
0.20991593599319458,
-0.01762561872601509,
0.1472122073173523,
-0.19967614114284515,
0.05524401366710663,
0.12442433834075928,
-0.05763334035873413,
-0.021388212218880653,
0.07481961697340012,
0.10783734172582626,
0.02741728536784649,
-0.2001154124736786,
-0.2715148627758026,
0.029325729236006737,
0.06268501281738281,
-0.09754791110754013,
-0.26893123984336853,
-0.005442675203084946,
0.28160348534584045,
-0.022299161180853844,
-0.06486636400222778,
0.24194684624671936,
0.09055649489164352,
-0.028747014701366425,
0.13125468790531158,
-0.0824938416481018,
0.08264360576868057,
-0.20044046640396118,
0.24059562385082245,
0.15287986397743225,
-0.18091924488544464,
0.06411225348711014,
0.04343322664499283,
-0.09610620141029358,
-0.12388745695352554,
0.10136165469884872,
-0.07897889614105225,
0.14950522780418396,
-0.15108366310596466,
-0.10329221189022064,
-0.1364150196313858,
0.1438239961862564,
0.2232898324728012,
-0.3626387119293213,
-0.06797364354133606,
0.06015608832240105,
-0.3399554193019867,
0.02102663367986679,
-0.03362061828374863,
0.25936388969421387,
-0.03366037458181381,
0.21147166192531586,
-0.03914692997932434,
0.08157730847597122,
-0.0204921867698431,
0.043071094900369644,
-0.14673370122909546,
0.17026197910308838,
0.11230719834566116,
0.051886241883039474,
0.1866670548915863,
0.022062018513679504,
0.16876740753650665,
-0.07795831561088562,
0.06445297598838806,
-0.11348162591457367,
0.2133406549692154,
-0.05092429369688034,
-0.46060121059417725,
-0.3780301809310913,
0.0015053856186568737,
0.07459091395139694,
0.11310984194278717,
0.14377368986606598,
0.24005097150802612,
0.17988081276416779,
0.20545966923236847,
0.05572205409407616,
0.3498280346393585,
-0.027628516778349876,
0.17554520070552826,
-0.08495620638132095,
-0.09107760339975357,
-0.3492758572101593,
0.13719266653060913,
0.031510189175605774,
-0.03688435256481171,
0.09498762339353561,
0.04926365241408348,
0.18708477914333344,
-0.20131966471672058,
-0.005325588863343,
0.1028599664568901,
0.13650144636631012,
-0.08498906344175339,
-0.04812876880168915,
0.03598431125283241,
0.012024756520986557,
-0.3429717719554901,
-0.028796739876270294,
0.005094720050692558,
-0.039248548448085785,
-0.1052214503288269,
-0.01819835603237152,
-0.013277600519359112,
0.2116110771894455,
0.04855430871248245,
0.0795653760433197,
-0.2378072887659073,
-0.11506277322769165,
0.07439588010311127,
0.07501007616519928,
0.16071230173110962,
0.11673881113529205,
-0.3927203118801117,
-0.1172562837600708,
0.010228990577161312,
-0.07396262139081955,
0.14178705215454102,
0.16966494917869568,
-0.06997346878051758,
0.1609109491109848,
-0.017110014334321022,
0.02860298566520214,
0.07295621186494827,
0.17426492273807526,
-0.013160239905118942,
-0.19303031265735626,
0.14148935675621033,
0.026028888300061226,
-0.18320150673389435,
-0.14694809913635254,
0.03514579311013222,
-0.0992409959435463,
0.0005015136557631195,
-0.12364275753498077,
0.024544645100831985,
-0.06952633708715439,
-0.041370779275894165,
-0.09684669971466064,
-0.058863699436187744,
0.13116726279258728,
-0.0725381076335907,
0.28046754002571106,
-0.3770684003829956,
0.04858266934752464,
-0.15968650579452515,
-0.0329933725297451,
0.09421990811824799,
-0.06768867373466492,
0.24431857466697693,
0.156685471534729,
0.12338714301586151,
-0.09633150696754456,
0.15513986349105835,
-0.2945561110973358,
-0.019427185878157616,
0.09605621546506882,
-0.3348850905895233,
-0.22880317270755768,
0.21190644800662994,
-0.2485823929309845,
-0.09386670589447021,
0.09267343580722809,
0.06907914578914642,
0.07735058665275574,
-0.02463056519627571,
-0.19702443480491638,
-0.18361744284629822,
0.2702856659889221,
-0.13023383915424347,
-0.15742933750152588,
-0.3454149067401886,
-0.10180680453777313,
0.1532086431980133,
0.027962975203990936,
0.03533479571342468,
-0.04543108493089676,
-0.02928013913333416,
0.20042867958545685,
-0.11465299874544144,
0.22525560855865479,
-0.11689645797014236,
0.19665424525737762,
0.01748661696910858,
0.07999653369188309,
-0.40751489996910095,
-0.10450316220521927,
0.07263515889644623,
0.14743392169475555,
0.20088748633861542,
-0.0557626374065876,
-0.04382789507508278,
0.20487454533576965,
-0.07344033569097519,
0.05898337438702583,
0.019552474841475487,
0.000555930775590241,
-0.27327415347099304,
0.13344720005989075,
-0.04200292006134987,
-0.21625864505767822,
-0.051934417337179184,
0.1827860325574875,
0.2324783354997635,
0.23384854197502136,
-0.3901258409023285,
-0.2819571793079376,
0.1380811482667923,
0.14528250694274902,
0.014864873141050339,
0.05473025143146515,
-0.22222201526165009,
0.22490538656711578,
-0.20282821357250214,
0.2149440348148346,
0.24380651116371155,
0.05206397548317909,
-0.04359380528330803,
-0.17156784236431122,
-0.1042206808924675,
0.11722540855407715,
-0.07963024824857712,
0.19997407495975494,
-0.21709811687469482,
-0.04729461297392845,
0.14802245795726776,
0.0981920138001442,
-0.04118632525205612,
-0.04768748581409454,
-0.014692091383039951,
-0.018382905051112175,
0.027983950451016426,
0.044688630849123,
0.18186424672603607,
-0.05257545784115791,
-0.27858617901802063,
0.11117146164178848,
-0.01634281873703003,
-0.16257639229297638,
0.14978334307670593,
0.2943819761276245,
-0.13984189927577972,
-0.17093461751937866,
-0.3413684070110321,
-0.0020828971173614264,
-0.028942734003067017,
0.008108392357826233,
0.21036119759082794,
-0.003296209964901209,
0.18723076581954956,
0.3091066777706146,
-0.0552380196750164,
-0.04349276050925255,
0.0058134193532168865,
0.1364671140909195,
-0.35827261209487915,
0.01862598955631256,
-0.052709370851516724,
0.022973161190748215,
0.0051293643191456795,
-0.05517292395234108,
0.11120740324258804,
0.2240820676088333,
0.23468439280986786,
-0.09899631887674332,
0.3234725594520569,
-0.000011203112990187947,
0.28927427530288696,
0.02215561829507351,
0.046984463930130005,
0.25038793683052063,
0.09905952215194702,
-0.30452287197113037,
-0.09332490712404251,
-0.13359206914901733,
-0.31245285272598267,
0.21745195984840393,
0.030771031975746155,
0.2193416804075241,
0.1650983840227127,
-0.15826204419136047,
-0.02022513747215271,
0.11048448830842972,
-0.128167524933815,
-0.09047582745552063,
0.3759917616844177,
-0.16648036241531372,
-0.16150477528572083,
0.17391985654830933,
0.15954411029815674,
0.1829940229654312,
-0.1503717601299286,
0.0756358802318573,
0.3518228828907013,
-0.22642391920089722,
0.10545332729816437,
-0.19446587562561035,
0.1086820438504219,
0.15736469626426697,
0.09607474505901337,
0.09235206246376038,
0.0690532848238945,
0.051200009882450104,
0.0985194593667984,
0.2131158858537674,
-0.07612941414117813,
0.2916087210178375,
-0.11872676759958267,
-0.057251762598752975,
-0.1485060155391693,
-0.09530311077833176,
0.16276662051677704,
0.013436360284686089,
0.15662838518619537,
0.169800266623497,
-0.059252239763736725,
0.09884151816368103,
0.03386788070201874,
0.24044042825698853,
0.1571090668439865,
-0.426297664642334,
0.011422480456531048,
0.17142035067081451,
-0.04611067846417427,
0.07179279625415802,
0.0325004905462265,
0.1992156207561493,
0.10845036059617996,
-0.04580692946910858,
-0.2646999955177307,
0.18008416891098022,
-0.15724368393421173,
-0.13602314889431,
0.20729954540729523,
0.15099301934242249,
0.0012339442037045956,
0.14222870767116547,
0.1272982358932495,
0.1399274468421936,
-0.11249237507581711,
0.16340303421020508,
0.04825124144554138,
-0.07387462258338928,
0.09509258717298508,
-0.18798841536045074,
-0.21509069204330444,
-0.05561951920390129,
-0.06644725054502487,
0.12149307131767273,
0.12422047555446625,
-0.056578632444143295,
-0.14120741188526154,
0.11421152204275131,
0.10011935234069824,
-0.02607225626707077,
-0.24559828639030457,
-0.1377212554216385,
0.2178679257631302,
-0.1057790070772171,
0.223228320479393,
0.08854493498802185,
0.1878601312637329,
-0.07587402313947678,
-0.19472819566726685,
-0.06779568642377853,
0.06441204994916916,
0.1662391573190689,
-0.14307428896427155,
0.1684195101261139,
-0.0776105746626854,
-0.02170979417860508,
0.16325801610946655,
0.12794671952724457,
-0.09070028364658356,
-0.21953096985816956,
-0.17845827341079712,
0.32455408573150635,
0.33246859908103943,
0.1544187217950821,
0.022950686514377594,
0.175559863448143,
0.06566811352968216,
-0.21364746987819672,
-0.08737678825855255,
0.007722015958279371,
-0.02531418204307556,
0.07371991872787476,
0.05156397074460983,
-0.19572800397872925,
0.05422229319810867,
-0.07157312333583832,
-0.20047929883003235,
0.16754814982414246,
0.15931130945682526,
0.000027330235752742738,
-0.09100110828876495,
0.05302446708083153,
-0.21720246970653534,
0.0785733163356781,
0.07453656941652298,
-0.04041333124041557,
0.2901408076286316,
0.23116828501224518,
-0.13714644312858582,
0.10620377212762833,
-0.2797754108905792,
-0.014357447624206543,
-0.25733670592308044,
-0.21174834668636322,
-0.06624692678451538,
-0.030885454267263412,
-0.010208692401647568,
-0.3521665036678314,
0.02618461661040783,
-0.2106979489326477,
-0.16738809645175934,
0.037367045879364014,
-0.1762397289276123,
-0.297293484210968,
0.26301997900009155,
0.15562519431114197,
-0.015859035775065422,
0.07513293623924255,
0.15673482418060303,
0.3955392837524414,
-0.024047939106822014,
-0.31477251648902893,
0.11885371059179306,
-0.09048089385032654,
0.0727875605225563,
-0.07615184783935547,
-0.30922931432724,
-0.1438630074262619,
-0.13847583532333374,
0.25958937406539917,
0.0273180790245533,
-0.02867353893816471,
-0.0929497703909874,
-0.34563377499580383,
-0.03852016478776932,
0.3710004985332489,
-0.06037905067205429,
-0.01436098013073206,
-0.02863805927336216,
-0.08582842350006104,
-0.10329704731702805,
-0.3804188072681427,
0.17446692287921906,
0.2687675654888153,
0.06922178715467453,
-0.25994646549224854,
0.1237446516752243,
-0.11865624785423279,
0.40769246220588684,
-0.07033514976501465,
0.18619096279144287,
0.029139962047338486,
0.057260558009147644,
0.1867751181125641,
-0.033171333372592926,
-0.12419693171977997,
-0.04491112381219864,
-0.09175948053598404,
-0.22610260546207428,
0.026015831157565117,
0.29701513051986694,
0.0639185979962349,
0.20223546028137207,
-0.2849466800689697,
-0.01972876861691475,
-0.1000569611787796,
-0.17845545709133148,
-0.0006932979449629784,
-0.07713612169027328,
0.0037307594902813435,
-0.34700945019721985,
0.1803113967180252,
0.19167907536029816,
0.14658904075622559,
-0.043510112911462784,
-0.04364811256527901,
-0.14258715510368347,
-0.22205008566379547,
-0.0002816277847159654,
0.02787664532661438,
-0.007145600859075785,
-0.10110197961330414,
0.01622997596859932,
-0.05015888810157776,
-0.31512346863746643,
-0.11597272753715515,
-0.14231009781360626,
-0.0775931179523468,
-0.32817086577415466,
0.011657705530524254,
0.10867712646722794,
0.24248354136943817,
-0.10808407515287399,
-0.10703475028276443,
0.02705984190106392,
-0.13742943108081818,
0.052728358656167984,
0.12434842437505722,
0.2967386841773987,
-0.10187684744596481,
-0.19184204936027527,
0.009274662472307682,
-0.21985642611980438,
-0.43144553899765015,
-0.09345251321792603,
0.1281709372997284,
0.0004420036275405437,
-0.21165557205677032,
0.13048529624938965,
-0.31769484281539917,
0.013958102092146873,
0.05237267538905144,
0.13924917578697205,
0.09009689837694168,
0.25920116901397705,
-0.04634767398238182,
-0.034079037606716156,
-0.22480565309524536,
0.1379336416721344,
0.04355733469128609,
0.14726436138153076,
-0.24541477859020233,
0.2048281580209732,
-0.188022181391716,
-0.017659498378634453,
0.08357679843902588,
0.16976222395896912,
0.29735127091407776,
0.01089085079729557,
-0.24078693985939026,
0.016660291701555252,
-0.0016474113799631596,
0.15649673342704773,
-0.3945443034172058,
-0.10088493674993515,
-0.03379260003566742,
0.11990644782781601,
0.0884455144405365,
0.1928785890340805,
-0.056487247347831726,
0.005095359403640032,
-0.016342956572771072,
0.38663461804389954,
0.04657045379281044,
0.22173944115638733,
-0.03376821056008339,
0.271289587020874,
0.11610264331102371,
0.018279289826750755,
-0.18473908305168152,
-0.2107212096452713,
0.20924243330955505,
0.002482801675796509,
-0.22383439540863037,
0.12315446138381958,
-0.09925390034914017,
-0.026071561500430107,
0.2038782835006714,
-0.06371329724788666,
0.2131505161523819,
-0.17954771220684052,
0.1252707540988922,
-0.01862775720655918,
0.2063358724117279,
-0.29074472188949585,
0.09215934574604034,
-0.33531272411346436,
0.16530711948871613,
-0.3530478775501251,
0.08414136618375778,
-0.39536163210868835,
0.16831187903881073,
-0.1781427413225174,
-0.15604595839977264,
0.021923590451478958,
-0.08564476668834686,
0.0006721099489368498,
-0.0693976879119873,
-0.10202181339263916,
0.2947598099708557,
0.2724159061908722,
-0.15176452696323395,
0.08907243609428406,
-0.0573868453502655,
0.38504865765571594,
-0.23869675397872925,
-0.11910571157932281,
0.09222827106714249,
0.1788049340248108,
-0.1564251333475113,
-0.13088636100292206,
0.24607297778129578,
0.08673886954784393,
0.0062811183743178844,
0.004979629069566727,
-0.29063552618026733,
0.0026990193873643875,
0.11694377660751343,
-0.10164099186658859,
0.22873562574386597,
0.08373240381479263,
-0.02212940715253353,
-0.23587900400161743,
0.234630286693573,
-0.10343778878450394,
0.44528672099113464,
0.06194721534848213,
-0.34797587990760803,
-0.3205770254135132,
-0.06835104525089264,
0.09972231835126877,
0.008767014369368553,
-0.006237396039068699,
-0.04992850869894028,
0.3812083899974823,
-0.2748914062976837,
0.022581562399864197,
-0.23404334485530853,
0.12808971107006073,
0.2973051965236664,
0.11096436530351639,
0.10383573919534683,
0.38182690739631653,
-0.1636066436767578,
-0.24990974366664886,
-0.10992029309272766,
-0.07147353887557983,
0.07021273672580719,
0.19740904867649078,
0.36394891142845154,
-0.24018160998821259,
-0.23230448365211487,
0.049939464777708054,
-0.12318799644708633,
0.009226868860423565,
-0.052036020904779434,
-0.16634123027324677,
-0.26538538932800293,
0.032359037548303604,
0.1901274025440216,
-0.08313672244548798,
0.1478334665298462,
-0.09082529693841934,
0.08706957846879959,
-0.11286326497793198,
-0.18561945855617523,
0.09915991872549057,
0.1877288520336151,
0.11622973531484604,
-0.0666576400399208,
-0.09489753842353821,
0.13091683387756348,
-0.12776000797748566,
-0.0009205206879414618,
0.17085568606853485,
-0.09365899860858917,
-0.07364959269762039,
-0.08523307740688324,
-0.38463371992111206,
0.22225111722946167,
-0.30370768904685974,
0.040419209748506546,
-0.02563253417611122,
0.09926983714103699,
0.0318448543548584,
-0.3382593095302582,
-0.09071237593889236,
0.07326365262269974,
-0.054115261882543564,
-0.2505495250225067,
0.003301419084891677,
0.3299802243709564,
-0.04808345064520836,
-0.006118686404079199,
-0.14409202337265015,
-0.11209186166524887,
-0.030646782368421555,
0.23254099488258362,
0.09473080933094025,
0.10951007157564163,
0.14825600385665894,
0.1129777655005455,
0.016967574134469032,
-0.21493498980998993,
0.09127932786941528,
-0.015971938148140907,
-0.1773436963558197,
-0.045772116631269455,
0.12150084227323532,
-0.01261799968779087,
-0.25025516748428345,
0.17734266817569733,
0.07535300403833389,
0.10615943372249603
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. variant, p.Tyr435Cys, has been detected in apparently asymptomatic or mildly affected children identified through newborn screening in Japan .NomenclaturePropionic acidemia and propionyl-CoA carboxylase deficiency are the two most common terms used to describe the condition. Ketotic hyperglycinemia was used in the 1960s before defects in propionyl-CoA carboxylase were determined to be the underlying cause of PA . The term propionic aciduria is used infrequently.PrevalenceWorldwide, the incidence of PA varies widely. The estimated live-birth incidence of PA is 1:105,000-1:130,000 in the US , 1:166,000 in Italy and 1:250,000 in Germany .The incidence appears to be higher in the Middle East. In the United Arab Emirates, the birth incidence of PA is ~1:20,000-1:45,000 . In Saudi Arabia the birth incidence is 1:28,000 , and can be | [
-0.0447380505502224,
0.13632072508335114,
0.0012660241918638349,
-0.2666015923023224,
0.30023831129074097,
0.0071054669097065926,
0.15827395021915436,
-0.26796820759773254,
0.06746362894773483,
-0.15618595480918884,
0.24143117666244507,
0.05697789043188095,
0.038141023367643356,
0.09449346363544464,
-0.2569917142391205,
0.19176402688026428,
0.1706693321466446,
0.015578076243400574,
-0.008793734014034271,
-0.2096918821334839,
0.006836170330643654,
-0.3241075873374939,
0.08652009069919586,
0.07059243321418762,
0.21904471516609192,
-0.10172896087169647,
0.1429070085287094,
-0.39399033784866333,
0.21752884984016418,
0.03504471108317375,
0.09416985511779785,
0.024264808744192123,
0.20635578036308289,
-0.2617174983024597,
-0.016269352287054062,
-0.163596510887146,
0.03409447520971298,
-0.27400070428848267,
-0.00043470654054544866,
-0.290451318025589,
0.21007774770259857,
-0.04223521798849106,
0.27310308814048767,
-0.09067254513502121,
0.16465993225574493,
-0.00625624181702733,
-0.05007953196763992,
-0.08809137344360352,
-0.06139175221323967,
0.2263277769088745,
0.3422410786151886,
-0.12583455443382263,
-0.19375193119049072,
-0.17678087949752808,
0.14246807992458344,
-0.06851648539304733,
-0.16223354637622833,
0.02635674551129341,
-0.22475656867027283,
0.22544965147972107,
0.05474552512168884,
-0.15403471887111664,
-0.16984347999095917,
-0.2719799876213074,
0.23975759744644165,
-0.06446482241153717,
0.03612595424056053,
0.16992437839508057,
0.2401050180196762,
-0.04498646408319473,
0.12088561058044434,
-0.05381359905004501,
0.1027005985379219,
0.06727275997400284,
-0.11917181313037872,
0.01256049145013094,
-0.027397610247135162,
0.06484414637088776,
0.06344518065452576,
-0.18775206804275513,
-0.28594478964805603,
0.1002134159207344,
0.07942183315753937,
0.016781043261289597,
-0.20630186796188354,
-0.03621432185173035,
0.2935005724430084,
-0.02565525658428669,
-0.13352186977863312,
0.2891944348812103,
0.10984378308057785,
-0.037846535444259644,
0.21334613859653473,
-0.03163642808794975,
0.06486484408378601,
-0.16404704749584198,
0.21821288764476776,
0.07308722287416458,
-0.1255112588405609,
0.14748232066631317,
0.04535354673862457,
-0.055929411202669144,
-0.15741248428821564,
0.08500738441944122,
-0.06677195429801941,
0.12358779460191727,
-0.1679619401693344,
-0.03558528795838356,
-0.10532336682081223,
0.11109979450702667,
0.22053809463977814,
-0.2627643346786499,
0.020405326038599014,
0.08977662771940231,
-0.31625616550445557,
-0.028145600110292435,
-0.05818812549114227,
0.23761774599552155,
-0.08158724755048752,
0.1360560655593872,
-0.07150747627019882,
0.0918269231915474,
-0.03321081027388573,
-0.016101621091365814,
-0.12409127503633499,
0.11343473196029663,
0.0979355126619339,
0.011698243208229542,
0.2735131084918976,
-0.02078341320157051,
0.19794751703739166,
-0.08392409235239029,
0.02468853071331978,
-0.10871043056249619,
0.19572849571704865,
0.03370486944913864,
-0.5000278949737549,
-0.3465460240840912,
0.021162671968340874,
0.029757685959339142,
0.15711931884288788,
0.2281794250011444,
0.29536548256874084,
0.16427171230316162,
0.17492704093456268,
0.0975789725780487,
0.36981987953186035,
0.005858100019395351,
0.15609240531921387,
-0.12959091365337372,
-0.08104291558265686,
-0.25293877720832825,
0.1529812067747116,
-0.06319164484739304,
-0.07676053047180176,
0.21770775318145752,
-0.06203889474272728,
0.21730390191078186,
-0.17782187461853027,
-0.021583009511232376,
0.07898285984992981,
0.07911457866430283,
-0.07457561045885086,
-0.02354956604540348,
0.03250741958618164,
0.09582298249006271,
-0.3480280637741089,
0.026584574952721596,
0.02206524834036827,
-0.019903162494301796,
-0.11808609217405319,
-0.06636665016412735,
-0.032106827944517136,
0.19149065017700195,
-0.006872259080410004,
0.014729385264217854,
-0.3057882487773895,
-0.13555030524730682,
0.008918383158743382,
0.08223948627710342,
0.14268679916858673,
0.0820712298154831,
-0.37551647424697876,
-0.11918827146291733,
-0.025417523458600044,
-0.156068354845047,
0.1221844032406807,
0.0953015387058258,
-0.0037415537517517805,
0.2240082323551178,
0.0441911406815052,
0.05178496614098549,
0.0060684266500175,
0.11621236801147461,
0.051042284816503525,
-0.25923609733581543,
0.16486461460590363,
0.11611658334732056,
-0.16848832368850708,
-0.07975461333990097,
-0.020242083817720413,
-0.15119720995426178,
0.12102945894002914,
-0.06699911504983902,
-0.014341382309794426,
-0.08734656870365143,
-0.040875665843486786,
-0.0615096390247345,
-0.07693503797054291,
0.11192840337753296,
-0.09496912360191345,
0.2732863426208496,
-0.2651621103286743,
0.004579458385705948,
-0.25791725516319275,
-0.04304919391870499,
0.03673195093870163,
-0.03417794778943062,
0.19074790179729462,
0.1957138180732727,
0.12713080644607544,
-0.05149851366877556,
0.16808119416236877,
-0.2843586206436157,
-0.03339891508221626,
0.16500183939933777,
-0.38278499245643616,
-0.18572837114334106,
0.17215785384178162,
-0.18963952362537384,
-0.1570151001214981,
0.14070136845111847,
0.13528209924697876,
0.15941031277179718,
0.023844584822654724,
-0.20375864207744598,
-0.11737310141324997,
0.2542775869369507,
-0.1484648585319519,
-0.009560716338455677,
-0.3524770438671112,
-0.015514937229454517,
0.19750458002090454,
-0.0033275128807872534,
0.009471321478486061,
0.050013069063425064,
-0.03785894438624382,
0.1403435468673706,
-0.10776347666978836,
0.12429837137460709,
-0.15725529193878174,
0.18726223707199097,
0.038077790290117264,
0.0011356105096638203,
-0.34843143820762634,
-0.17417272925376892,
0.04850218445062637,
0.033696435391902924,
0.1459350287914276,
-0.03233376890420914,
-0.013128206133842468,
0.21333728730678558,
-0.03540370985865593,
0.11104516685009003,
-0.012743661180138588,
0.07511696964502335,
-0.1768174022436142,
0.10296623408794403,
-0.02065046690404415,
-0.1536838859319687,
-0.014413110911846161,
0.10327982902526855,
0.23312169313430786,
0.21106673777103424,
-0.3263588845729828,
-0.2330537736415863,
0.05632946267724037,
0.1457403004169464,
0.023549197241663933,
0.022745009511709213,
-0.24388757348060608,
0.2177499681711197,
-0.15315794944763184,
0.23927795886993408,
0.21930573880672455,
0.03723529726266861,
-0.06059896945953369,
-0.07773443311452866,
-0.12572072446346283,
0.06473909318447113,
-0.028066318482160568,
0.16041570901870728,
-0.15724703669548035,
-0.04435783252120018,
0.20268608629703522,
0.17243292927742004,
-0.1287187784910202,
0.03367733955383301,
-0.0786144807934761,
-0.06906843185424805,
0.03694610297679901,
0.026346499100327492,
0.09207979589700699,
-0.07867062091827393,
-0.3444252014160156,
0.17663879692554474,
-0.017515312880277634,
-0.17062333226203918,
0.08420701324939728,
0.3144066333770752,
-0.17776717245578766,
-0.2036237120628357,
-0.29943132400512695,
0.12658771872520447,
-0.04419410228729248,
-0.07752329856157303,
0.20942753553390503,
0.1050553098320961,
0.215189129114151,
0.3170582950115204,
0.003619920462369919,
-0.06139485165476799,
0.09005158394575119,
0.0496295802295208,
-0.3077978491783142,
0.1209162250161171,
-0.16068542003631592,
0.048893991857767105,
0.07292921841144562,
-0.1364561766386032,
0.19643256068229675,
0.12017953395843506,
0.13612870872020721,
-0.10895874351263046,
0.29083114862442017,
0.06797119975090027,
0.3432116210460663,
-0.00010943182132905349,
0.029429849237203598,
0.14882907271385193,
0.051218181848526,
-0.28338608145713806,
-0.07140374928712845,
-0.025757675990462303,
-0.2982684373855591,
0.21006248891353607,
0.012211616151034832,
0.12228702753782272,
0.18730276823043823,
-0.10593254119157791,
-0.013340488076210022,
0.14219287037849426,
-0.1821560263633728,
-0.10978732258081436,
0.44269728660583496,
-0.19148008525371552,
-0.1531650573015213,
0.16435720026493073,
0.11640150099992752,
0.12608711421489716,
-0.24177013337612152,
-0.05043650418519974,
0.4153589904308319,
-0.24261288344860077,
0.1330873668193817,
-0.1576080024242401,
0.12855900824069977,
0.22824423015117645,
0.07360822707414627,
0.1029413715004921,
0.17827048897743225,
0.16367171704769135,
0.05871930718421936,
0.08117728680372238,
-0.04429208114743233,
0.20294959843158722,
-0.07869423180818558,
0.04422673583030701,
-0.15253330767154694,
-0.18549077212810516,
0.19055718183517456,
-0.049283601343631744,
0.061545658856630325,
0.1114511787891388,
-0.003636040724813938,
0.17482174932956696,
0.09281975775957108,
0.22228369116783142,
0.12339574098587036,
-0.38030076026916504,
0.11791878938674927,
0.10768089443445206,
-0.02132665365934372,
0.15998491644859314,
0.08701655268669128,
0.17481638491153717,
0.12239260226488113,
-0.03875229135155678,
-0.2671847939491272,
0.24329179525375366,
-0.14402392506599426,
-0.14369024336338043,
0.12178733944892883,
0.17376036942005157,
0.06541674584150314,
0.09265349805355072,
0.02310112863779068,
0.11226669698953629,
-0.0533100962638855,
0.14673247933387756,
0.053015291690826416,
-0.09202828258275986,
0.04677138477563858,
-0.25470778346061707,
-0.15287548303604126,
0.015411680564284325,
-0.15192097425460815,
0.014385920017957687,
0.13067670166492462,
-0.06354970484972,
-0.10633482784032822,
0.17971980571746826,
0.0873827263712883,
-0.02596306800842285,
-0.2629440426826477,
-0.11688243597745895,
0.19447824358940125,
-0.07188230752944946,
0.19725929200649261,
0.14817900955677032,
0.2616178095340729,
-0.03393244743347168,
-0.20204436779022217,
-0.11906803399324417,
0.07254143059253693,
0.029608767479658127,
-0.1651919186115265,
0.09680687636137009,
0.010257095098495483,
-0.1049046516418457,
0.18142159283161163,
0.05393138900399208,
-0.1635364443063736,
-0.11146532744169235,
-0.12380979210138321,
0.31545355916023254,
0.3069988191127777,
0.20638051629066467,
0.006953558884561062,
0.09652046859264374,
0.09766827523708344,
-0.19045905768871307,
-0.02829466015100479,
-0.01533694751560688,
0.00047320110024884343,
0.05703094229102135,
-0.02161566913127899,
-0.23543386161327362,
0.11421069502830505,
-0.08782261610031128,
-0.2175469845533371,
0.15356308221817017,
0.2435659021139145,
-0.025994285941123962,
-0.051940035074949265,
0.0962192639708519,
-0.24147909879684448,
0.02210366353392601,
0.033282581716775894,
-0.06425735354423523,
0.24836178123950958,
0.10070782154798508,
-0.0847475603222847,
0.11331701278686523,
-0.2646327614784241,
0.03341800719499588,
-0.18218185007572174,
-0.13908949494361877,
-0.09863916039466858,
0.09787016361951828,
0.0004748013452626765,
-0.3070129156112671,
0.03757748007774353,
-0.24407951533794403,
-0.18341320753097534,
0.09890598058700562,
-0.13098058104515076,
-0.29716676473617554,
0.3374682366847992,
0.16281139850616455,
0.02031562849879265,
0.09393571317195892,
0.11455141752958298,
0.3460574150085449,
0.02992996759712696,
-0.2782909870147705,
0.09675303101539612,
-0.195127934217453,
0.09091833978891373,
0.08259598165750504,
-0.2541404962539673,
-0.19458907842636108,
-0.14085769653320312,
0.30437594652175903,
0.018733562901616096,
0.06002273038029671,
-0.00228953012265265,
-0.23830662667751312,
0.05157085880637169,
0.3343276381492615,
-0.083391934633255,
0.060203421860933304,
-0.13305754959583282,
-0.11248967796564102,
-0.09005267918109894,
-0.36151209473609924,
0.17881076037883759,
0.30185675621032715,
0.017620554193854332,
-0.2762284278869629,
0.12611544132232666,
-0.10675881057977676,
0.39626234769821167,
-0.02743556536734104,
0.17155756056308746,
-0.038446955382823944,
0.03171207755804062,
0.18467919528484344,
-0.0755421370267868,
-0.09637654572725296,
-0.016642197966575623,
-0.08387210965156555,
-0.2392454296350479,
0.035090237855911255,
0.23879043757915497,
0.08927097916603088,
0.19600577652454376,
-0.24745453894138336,
-0.07536376267671585,
-0.08421330153942108,
-0.1474277675151825,
0.025965647771954536,
-0.08705748617649078,
0.01397925615310669,
-0.3609628677368164,
0.14262808859348297,
0.064886175096035,
0.08337206393480301,
-0.06287848949432373,
-0.03971327841281891,
-0.1374414563179016,
-0.17492637038230896,
-0.007931020110845566,
0.061333462595939636,
0.03544815257191658,
-0.07410933077335358,
-0.019041260704398155,
-0.11124594509601593,
-0.340172678232193,
-0.06307587027549744,
-0.13954293727874756,
-0.04079589992761612,
-0.26284608244895935,
0.03376448154449463,
0.06711109727621078,
0.27168482542037964,
-0.06609386205673218,
-0.16026777029037476,
-0.024288799613714218,
-0.1778179407119751,
0.013394436798989773,
0.1410176008939743,
0.25121283531188965,
-0.1947956681251526,
-0.2090051770210266,
-0.022689640522003174,
-0.24810755252838135,
-0.49577808380126953,
-0.15951867401599884,
0.2277492731809616,
0.04631848260760307,
-0.12763124704360962,
0.14732134342193604,
-0.25105583667755127,
-0.015574685297906399,
0.022456463426351547,
0.180204376578331,
0.11399416625499725,
0.2907082438468933,
-0.0695645809173584,
-0.03603686764836311,
-0.2472357451915741,
0.16130639612674713,
0.03845621272921562,
0.14492635428905487,
-0.24961961805820465,
0.1961553543806076,
-0.08421297371387482,
-0.0015567669179290533,
0.07097003608942032,
0.1696811467409134,
0.26110249757766724,
0.03167496994137764,
-0.13886158168315887,
0.0051969666965305805,
-0.04261371120810509,
0.14776061475276947,
-0.36596912145614624,
-0.04256455600261688,
0.008838207460939884,
0.06454046815633774,
0.05822601169347763,
0.04775354638695717,
-0.06133619323372841,
0.027599962428212166,
-0.04442934691905975,
0.32922130823135376,
0.023794343695044518,
0.2448381930589676,
-0.03759289160370827,
0.38737642765045166,
0.10025230795145035,
0.08316726982593536,
-0.1416626274585724,
-0.2555164694786072,
0.2773717939853668,
0.006990125868469477,
-0.1801905632019043,
0.1661309003829956,
-0.1046982929110527,
-0.020713208243250847,
0.2816501259803772,
0.0002305521338712424,
0.20552650094032288,
-0.11377406865358353,
0.1807938516139984,
0.00924754049628973,
0.07120365649461746,
-0.24103917181491852,
0.10701999813318253,
-0.24646815657615662,
0.1513357311487198,
-0.24930380284786224,
0.06525156646966934,
-0.40435245633125305,
0.2139180600643158,
-0.11894501000642776,
-0.16450485587120056,
0.050882577896118164,
-0.13429862260818481,
-0.055981408804655075,
-0.06091238185763359,
-0.019908688962459564,
0.26302868127822876,
0.21180476248264313,
-0.13582025468349457,
0.07966175675392151,
-0.13513588905334473,
0.3392806351184845,
-0.22494223713874817,
-0.09858981519937515,
0.05957285314798355,
0.2039853185415268,
-0.11384792625904083,
-0.15864601731300354,
0.27122363448143005,
0.05448855832219124,
-0.002305487170815468,
0.0470006987452507,
-0.3766457736492157,
-0.01742548868060112,
0.08286632597446442,
-0.03497971594333649,
0.1291513442993164,
0.05567241832613945,
-0.05554801598191261,
-0.24694615602493286,
0.13662217557430267,
0.029099537059664726,
0.47320130467414856,
0.07549126446247101,
-0.37200620770454407,
-0.3638552725315094,
-0.029671041294932365,
0.12797591090202332,
0.0591513030230999,
0.007957814261317253,
-0.10689277946949005,
0.3808768093585968,
-0.2968621253967285,
0.03424675762653351,
-0.1726790815591812,
0.1606694459915161,
0.30981066823005676,
0.1555185168981552,
0.09461171180009842,
0.44088882207870483,
-0.07381819933652878,
-0.21633857488632202,
-0.12334267795085907,
0.04335273057222366,
0.07725043594837189,
0.174458310008049,
0.367545485496521,
-0.20039691030979156,
-0.22812874615192413,
0.0021815698128193617,
-0.08387503772974014,
0.061445724219083786,
-0.03530232980847359,
-0.15733157098293304,
-0.2856159210205078,
-0.029052313417196274,
0.2707454562187195,
-0.15049773454666138,
0.17617663741111755,
-0.18530738353729248,
0.09728606790304184,
-0.1494932323694229,
-0.18024449050426483,
0.09914419054985046,
0.10346013307571411,
0.10570468008518219,
-0.17926795780658722,
-0.09108156710863113,
0.23233561217784882,
-0.16310681402683258,
0.11208076030015945,
0.22376862168312073,
-0.16066443920135498,
-0.13147245347499847,
-0.13042378425598145,
-0.3580852448940277,
0.18968622386455536,
-0.1719442456960678,
0.09992852061986923,
-0.022061768919229507,
0.13806955516338348,
-0.01669527404010296,
-0.3152373135089874,
-0.06479410082101822,
0.08898666501045227,
-0.03885846212506294,
-0.24189771711826324,
-0.015723537653684616,
0.21117611229419708,
-0.0736897736787796,
-0.0928109735250473,
-0.18944570422172546,
-0.16635103523731232,
-0.00009943747863871977,
0.17647576332092285,
0.010244314558804035,
0.06216241791844368,
0.10541080683469772,
0.08469189703464508,
0.03912791609764099,
-0.24688468873500824,
0.05114326253533363,
-0.03281768783926964,
-0.15417350828647614,
0.03107886202633381,
0.12221784889698029,
0.02431386336684227,
-0.14036442339420319,
0.20230399072170258,
0.014618556946516037,
0.03488115966320038
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. incidence of PA varies widely. The estimated live-birth incidence of PA is 1:105,000-1:130,000 in the US , 1:166,000 in Italy and 1:250,000 in Germany .The incidence appears to be higher in the Middle East. In the United Arab Emirates, the birth incidence of PA is ~1:20,000-1:45,000 . In Saudi Arabia the birth incidence is 1:28,000 , and can be higher in some Saudi tribes: 1:2000-1:5000 .In Japan, the live birth incidence of severe propionic acidemia is 1:465,000, but increases to 1:17,400 when combined with an apparently asymptomatic form of PA identified through newborn screening .The highest reported birth incidence is found among the Greenlandic Inuits: 1:1000 .Differential DiagnosisElevated C3 (propionylcarnitine) on newborn screening can be caused | [
-0.1463930457830429,
0.16130980849266052,
0.05378265306353569,
-0.18384473025798798,
0.1706918478012085,
-0.006707708816975355,
0.10014193505048752,
-0.2602803409099579,
-0.020396245643496513,
0.058801598846912384,
-0.0367109589278698,
0.1524282991886139,
0.025909289717674255,
0.2145508974790573,
-0.2237301766872406,
0.057116735726594925,
0.19614364206790924,
0.028561417013406754,
0.03125695884227753,
-0.16410930454730988,
0.06700956076383591,
-0.3059128224849701,
0.02560959942638874,
0.06213793903589249,
0.19547776877880096,
-0.23345345258712769,
-0.017537033185362816,
-0.24981102347373962,
0.21939511597156525,
0.07595386356115341,
0.11946962773799896,
0.052414458245038986,
0.18287330865859985,
-0.18719306588172913,
0.057916998863220215,
-0.06918137520551682,
0.04594113305211067,
-0.22929169237613678,
0.010333185084164143,
-0.23771996796131134,
0.21893876791000366,
-0.023400859907269478,
0.2796882092952728,
0.02515455149114132,
0.08924419432878494,
-0.07079795747995377,
-0.024410871788859367,
-0.022597109898924828,
-0.148763045668602,
0.269659161567688,
0.3565811514854431,
-0.07297538965940475,
-0.2539900839328766,
-0.033471010625362396,
0.11501733213663101,
-0.04133918508887291,
-0.16387762129306793,
0.011672800406813622,
-0.24655766785144806,
0.10794756561517715,
-0.0001008902327157557,
-0.2884996831417084,
0.03091338463127613,
-0.3482019603252411,
0.2609789967536926,
-0.03894209489226341,
0.17515243589878082,
0.20094037055969238,
0.23235276341438293,
-0.08648419380187988,
0.1148456484079361,
0.08152665197849274,
0.08861543238162994,
0.07567786425352097,
-0.18619635701179504,
0.18062296509742737,
-0.016384359449148178,
0.016626164317131042,
-0.051242563873529434,
-0.37831130623817444,
-0.17627094686031342,
0.11047183722257614,
0.11527634412050247,
0.1348351389169693,
-0.11588588356971741,
-0.04069843888282776,
0.24186883866786957,
0.0834798738360405,
-0.1661958396434784,
0.27689123153686523,
0.04120159521698952,
-0.08582452684640884,
0.1084696501493454,
-0.1775963306427002,
0.1218867301940918,
-0.09836795181035995,
0.1321074366569519,
0.031112778931856155,
-0.15192854404449463,
0.0484764464199543,
0.025954626500606537,
0.10779260098934174,
-0.12547631561756134,
-0.03237892687320709,
0.01583540067076683,
0.08217579126358032,
-0.06482277810573578,
0.03302536904811859,
-0.012706193141639233,
0.09831912815570831,
0.17897561192512512,
-0.17819800972938538,
0.11900941282510757,
0.03522446006536484,
-0.41066861152648926,
0.04391631856560707,
-0.18044768273830414,
0.2463780790567398,
-0.16379114985466003,
-0.007880289107561111,
-0.0628705695271492,
0.05405500531196594,
-0.020248783752322197,
-0.07599139958620071,
-0.09104111045598984,
0.09772762656211853,
-0.02736247517168522,
-0.10083078593015671,
0.13187281787395477,
-0.11825446039438248,
0.1047721728682518,
0.10431312024593353,
-0.06190420687198639,
-0.11493862420320511,
0.17002800107002258,
0.039044853299856186,
-0.28515419363975525,
-0.29532694816589355,
-0.06584866344928741,
-0.09660561382770538,
0.14208848774433136,
0.30351242423057556,
0.26858994364738464,
0.15587417781352997,
0.30381953716278076,
0.10243579745292664,
0.37336501479148865,
-0.06100938096642494,
0.2063121348619461,
-0.005701713729649782,
0.1489803045988083,
-0.23403409123420715,
0.15798060595989227,
-0.09484593570232391,
-0.13126541674137115,
0.1297844797372818,
0.025123104453086853,
0.22865678369998932,
0.02040213905274868,
0.09324803203344345,
-0.09790214896202087,
-0.019221710041165352,
-0.1086026057600975,
-0.15737289190292358,
-0.028377803042531013,
-0.0189023707062006,
-0.2687418758869171,
0.07939302921295166,
-0.0850948691368103,
-0.11629855632781982,
-0.03775183483958244,
-0.07006773352622986,
-0.012125669978559017,
0.1640593707561493,
0.11121643334627151,
0.1439104825258255,
-0.3052156865596771,
0.025267407298088074,
-0.006223516073077917,
0.15233749151229858,
0.08052873611450195,
-0.04641546681523323,
-0.20997092127799988,
-0.17016291618347168,
-0.13422369956970215,
-0.24112899601459503,
0.15317261219024658,
0.09087672829627991,
-0.06837603449821472,
0.23042647540569305,
0.1908087432384491,
0.06343135982751846,
-0.005412677302956581,
0.1241147518157959,
0.0777621865272522,
-0.31968000531196594,
0.08855454623699188,
-0.03837539628148079,
-0.1970539689064026,
-0.039926301687955856,
-0.2384129762649536,
-0.21028724312782288,
0.2635638117790222,
0.019099071621894836,
0.06424812972545624,
-0.21637210249900818,
-0.012140726670622826,
-0.053320638835430145,
-0.04854387789964676,
0.0824269950389862,
-0.08118421584367752,
0.19431111216545105,
-0.21479536592960358,
-0.03324808180332184,
-0.2579888105392456,
-0.1546502560377121,
0.18683819472789764,
-0.07352917641401291,
0.11290169507265091,
0.047309841960668564,
-0.03072497248649597,
0.058192990720272064,
0.04858949035406113,
-0.26254338026046753,
-0.02895289845764637,
0.09978228062391281,
-0.3906114995479584,
-0.16845828294754028,
0.09940625727176666,
-0.2003626972436905,
-0.09518426656723022,
0.14128273725509644,
0.058563534170389175,
0.1809471845626831,
-0.04661043360829353,
-0.12656480073928833,
-0.0874134972691536,
0.19577330350875854,
-0.08649756014347076,
0.1532018631696701,
-0.308520644903183,
-0.003652431769296527,
0.12198273837566376,
0.03990171477198601,
0.12552905082702637,
0.06520920246839523,
-0.026447104290127754,
0.055892422795295715,
-0.014812455512583256,
0.07590577751398087,
-0.0020916368812322617,
0.21705414354801178,
-0.04374932125210762,
-0.00214362726546824,
-0.23414622247219086,
-0.23914846777915955,
0.06999698281288147,
0.05977688357234001,
0.10543972998857498,
0.10600074380636215,
-0.07581043243408203,
0.26918432116508484,
0.030603930354118347,
0.22692884504795074,
-0.04087767377495766,
0.01727241650223732,
-0.11769574135541916,
-0.0034673400223255157,
0.08789161592721939,
-0.16265226900577545,
-0.07232467085123062,
0.08048588037490845,
0.18637190759181976,
0.08247353136539459,
-0.19386854767799377,
-0.18086370825767517,
-0.04363048076629639,
0.01583860069513321,
0.08808910101652145,
-0.0046319300308823586,
-0.023247672244906425,
0.07833975553512573,
-0.052612435072660446,
0.07446671277284622,
0.23156753182411194,
-0.03953831270337105,
-0.10252103954553604,
0.09032606333494186,
-0.14929309487342834,
-0.03386928513646126,
-0.06460084021091461,
0.21358714997768402,
-0.09952305257320404,
0.041875045746564865,
0.2446489930152893,
0.31340423226356506,
-0.08810972422361374,
0.1410331428050995,
0.054876089096069336,
-0.023187441751360893,
0.06620408594608307,
0.07172801345586777,
0.045314256101846695,
-0.17598532140254974,
-0.23462367057800293,
0.020509513095021248,
0.05132591351866722,
-0.16793499886989594,
0.029922936111688614,
0.2845522463321686,
-0.2426748424768448,
-0.15699352324008942,
-0.19194774329662323,
0.1758829802274704,
-0.028658123686909676,
-0.18966160714626312,
0.20364952087402344,
0.22619934380054474,
0.17761550843715668,
0.328100323677063,
0.08415155857801437,
-0.021483302116394043,
0.11365094780921936,
-0.008751006796956062,
-0.27206000685691833,
0.0496014766395092,
-0.17935530841350555,
0.08578071743249893,
-0.04910099878907204,
-0.058556195348501205,
0.1656367927789688,
0.05195844545960426,
-0.08121848851442337,
-0.07307770103216171,
0.26215115189552307,
0.03535911440849304,
0.4383828639984131,
-0.021365279331803322,
-0.14802907407283783,
0.013833724893629551,
0.11791656911373138,
-0.31280237436294556,
-0.05887484550476074,
-0.07840212434530258,
-0.19731846451759338,
-0.12120252102613449,
-0.06459492444992065,
-0.09683455526828766,
0.14606042206287384,
-0.13469155132770538,
0.046765830367803574,
0.03989585116505623,
-0.203570157289505,
-0.058505233377218246,
0.4329052269458771,
-0.2904118597507477,
-0.04654327780008316,
0.0657624676823616,
0.16570450365543365,
0.034567467868328094,
-0.3110141158103943,
-0.09016356617212296,
0.3036925792694092,
-0.2235087901353836,
0.13794229924678802,
-0.10748752951622009,
0.049195051193237305,
0.18051297962665558,
0.10199007391929626,
0.014741430059075356,
0.16311956942081451,
0.19050125777721405,
-0.005633167456835508,
0.13645312190055847,
0.013688267208635807,
0.2281564325094223,
0.002150935586541891,
0.199222594499588,
-0.3103638291358948,
-0.32673490047454834,
0.12949641048908234,
0.03922411799430847,
-0.01620149239897728,
-0.053937461227178574,
-0.06219620630145073,
0.1560007482767105,
-0.05658714845776558,
0.12525343894958496,
0.166601300239563,
-0.4016023874282837,
0.22331219911575317,
-0.018757063895463943,
0.04862053692340851,
0.22273318469524384,
0.19420126080513,
0.14784356951713562,
0.05665869638323784,
0.058393917977809906,
-0.1650879979133606,
0.19027791917324066,
-0.21013152599334717,
0.04236125573515892,
0.14573001861572266,
0.17228735983371735,
0.2503145635128021,
0.0251141507178545,
-0.0714053139090538,
0.09896360337734222,
-0.15709826350212097,
0.03739979863166809,
0.010424367152154446,
0.035706281661987305,
0.04871318116784096,
-0.2966468334197998,
-0.124481201171875,
0.12317433953285217,
-0.2298073172569275,
-0.17283105850219727,
0.03873208165168762,
-0.05165693536400795,
0.0699089914560318,
0.02040114812552929,
-0.06583591550588608,
-0.07825756818056107,
-0.1291784644126892,
0.018492206931114197,
0.12048904597759247,
-0.0057848612777888775,
0.08886872231960297,
0.2797291874885559,
0.22903944551944733,
-0.09832951426506042,
-0.1845749318599701,
-0.16951864957809448,
-0.07777569442987442,
0.04725875332951546,
-0.13470247387886047,
0.006716657895594835,
-0.010250668972730637,
-0.14680804312229156,
0.15073440968990326,
-0.0003379855479579419,
-0.2569921910762787,
-0.07860264182090759,
-0.11949657648801804,
0.23953799903392792,
0.16567586362361908,
0.07377392053604126,
0.0033499354030936956,
0.10994696617126465,
0.10508552193641663,
-0.13140086829662323,
-0.02934509888291359,
-0.013375996612012386,
-0.10496269166469574,
0.038348156958818436,
-0.006493574474006891,
-0.1658385545015335,
0.1572599560022354,
-0.06752008944749832,
-0.186554953455925,
0.19187648594379425,
0.2499217391014099,
-0.12980441749095917,
-0.03769436478614807,
0.13583286106586456,
-0.2337053418159485,
-0.0022749672643840313,
0.017123360186815262,
-0.0015113591216504574,
0.04182896018028259,
-0.12597429752349854,
-0.11184725165367126,
-0.025039171800017357,
-0.2599274516105652,
-0.08713117241859436,
-0.0041749258525669575,
-0.010414432734251022,
-0.05745800957083702,
0.16485123336315155,
0.007806340232491493,
-0.12633223831653595,
0.004990220535546541,
-0.14566820859909058,
-0.16901631653308868,
0.14976617693901062,
-0.2663937509059906,
-0.09105827659368515,
0.3012024462223053,
0.13901396095752716,
-0.03437391668558121,
0.08414050936698914,
-0.060961343348026276,
0.2531203627586365,
0.004401505924761295,
-0.2817327082157135,
-0.00909809023141861,
-0.23791958391666412,
0.061875659972429276,
0.1286250352859497,
-0.08416527509689331,
-0.06039268150925636,
-0.06517063826322556,
0.2093389332294464,
0.061265792697668076,
0.12965895235538483,
-0.13906368613243103,
-0.11425913870334625,
0.21716582775115967,
0.10537803918123245,
-0.032494012266397476,
0.16355514526367188,
-0.16664262115955353,
-0.14467467367649078,
0.021122397854924202,
-0.3240717649459839,
0.046805404126644135,
0.31403911113739014,
-0.019888218492269516,
-0.2590092420578003,
0.11085288971662521,
-0.05165129899978638,
0.30553656816482544,
-0.010883878916501999,
0.09848418086767197,
-0.10303482413291931,
0.0485626757144928,
0.21534468233585358,
0.0011686242651194334,
-0.21146966516971588,
0.03866763785481453,
-0.180190771818161,
-0.19034060835838318,
0.036818504333496094,
0.28019630908966064,
-0.0268078725785017,
0.046484045684337616,
-0.1389789879322052,
-0.2035883069038391,
-0.0875423401594162,
-0.04739948734641075,
0.09089228510856628,
-0.038923341780900955,
-0.004883133340626955,
-0.22766578197479248,
0.14248669147491455,
0.11020510643720627,
-0.007974964566528797,
0.03388772904872894,
-0.02156985178589821,
-0.0899505540728569,
-0.1107577458024025,
0.09394051134586334,
-0.11847980320453644,
-0.07649751752614975,
-0.08313792943954468,
-0.11906307935714722,
-0.159663587808609,
-0.24187268316745758,
0.05228402838110924,
-0.11642336845397949,
-0.03243223577737808,
-0.19129224121570587,
0.08341818302869797,
-0.0768984705209732,
0.2766713798046112,
0.009894637390971184,
-0.12403951585292816,
-0.03769976273179054,
-0.25294697284698486,
-0.04108700901269913,
0.037388067692518234,
0.1316652148962021,
-0.1391773521900177,
-0.18834608793258667,
-0.036451149731874466,
-0.18432959914207458,
-0.5231446027755737,
-0.16360825300216675,
0.2507002055644989,
0.10858852416276932,
-0.08484631776809692,
0.1221475750207901,
-0.21082580089569092,
-0.044149842113256454,
0.06975942105054855,
0.20356057584285736,
0.09286938607692719,
0.17074713110923767,
-0.01863875985145569,
-0.010084422305226326,
-0.22511734068393707,
0.11247527599334717,
0.06470154225826263,
0.06333199143409729,
-0.1668587177991867,
0.2443079799413681,
-0.13331744074821472,
0.11382336169481277,
0.09087849408388138,
0.010378486476838589,
0.13394911587238312,
0.04996616393327713,
-0.08472372591495514,
0.0029935266356915236,
-0.16015112400054932,
0.19901786744594574,
-0.339534193277359,
-0.030181897804141045,
0.025514934211969376,
0.03211016580462456,
0.07747208327054977,
-0.03395352140069008,
-0.0788203626871109,
0.06526347994804382,
-0.007053240202367306,
0.20723406970500946,
-0.022418787702918053,
0.21825358271598816,
-0.0839519277215004,
0.2880839407444,
0.1663307249546051,
0.08265749365091324,
-0.08115962147712708,
-0.22149160504341125,
0.20243743062019348,
0.003921666648238897,
-0.16675999760627747,
0.24195954203605652,
0.012572205625474453,
-0.09347247332334518,
0.304165780544281,
0.111399345099926,
-0.05094536393880844,
-0.047861188650131226,
0.10950415581464767,
0.07579919695854187,
-0.019587673246860504,
-0.030435221269726753,
0.013348173350095749,
-0.16700415313243866,
0.18535377085208893,
-0.15905018150806427,
0.19089080393314362,
-0.3435725271701813,
0.16163553297519684,
-0.09095647186040878,
-0.10856115818023682,
0.11051180958747864,
-0.1343201994895935,
-0.00036919995909556746,
-0.08608376234769821,
0.1401246339082718,
0.2511163353919983,
0.2552747428417206,
-0.12377328425645828,
0.1517590880393982,
-0.1682671457529068,
0.38362306356430054,
-0.1643015295267105,
-0.12354276329278946,
0.09269095957279205,
0.1166987195611,
0.021860487759113312,
-0.10301979631185532,
0.25423163175582886,
0.06623917818069458,
-0.024763232097029686,
0.015936046838760376,
-0.436939001083374,
-0.21421439945697784,
0.042161788791418076,
0.017807181924581528,
0.024877719581127167,
-0.015574962832033634,
0.11936566978693008,
-0.20561674237251282,
0.16142214834690094,
-0.051249340176582336,
0.384299099445343,
0.017784636467695236,
-0.30341923236846924,
-0.2759569585323334,
0.06095859780907631,
0.027609266340732574,
0.08405143022537231,
-0.0022541414946317673,
-0.18472173810005188,
0.16880880296230316,
-0.30423906445503235,
-0.048560503870248795,
-0.10329613834619522,
0.1738351434469223,
0.22138549387454987,
0.20484785735607147,
0.054754529148340225,
0.3598616123199463,
-0.07101381570100784,
-0.2814605236053467,
-0.12853385508060455,
-0.027077341452240944,
0.040077026933431625,
0.1407116800546646,
0.25963836908340454,
-0.24468325078487396,
-0.12839896976947784,
0.13915090262889862,
-0.09461002051830292,
0.08512488007545471,
-0.008632410317659378,
-0.09095236659049988,
-0.1778867542743683,
0.0005360090872272849,
0.19782865047454834,
-0.10574068874120712,
0.26004210114479065,
-0.18460877239704132,
0.20494942367076874,
-0.1574729084968567,
-0.14149586856365204,
0.1788032501935959,
-0.07049588859081268,
0.1322495937347412,
-0.09660934656858444,
-0.06664007902145386,
0.1154017373919487,
-0.1607781946659088,
0.07656771689653397,
0.2763662040233612,
-0.13182426989078522,
-0.2227756530046463,
-0.16859596967697144,
-0.27972304821014404,
0.0690084919333458,
-0.12436321377754211,
0.22390489280223846,
-0.021712100133299828,
0.12685008347034454,
-0.005931488238275051,
-0.2990603744983673,
-0.1536540985107422,
0.15991532802581787,
0.042118240147829056,
-0.13408206403255463,
0.04343295469880104,
0.08746834099292755,
0.00798774417489767,
-0.19574633240699768,
-0.23569756746292114,
-0.2039482593536377,
0.17566704750061035,
0.16455046832561493,
-0.025920167565345764,
0.0574534647166729,
0.07812859117984772,
0.052637867629528046,
0.007914270274341106,
-0.1745299994945526,
0.1602928638458252,
-0.10437469184398651,
-0.08925154060125351,
0.08331712335348129,
0.04917332902550697,
0.04409497231245041,
-0.20374205708503723,
0.13562726974487305,
0.10258025676012039,
-0.07502332329750061
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. ,000 , and can be higher in some Saudi tribes: 1:2000-1:5000 .In Japan, the live birth incidence of severe propionic acidemia is 1:465,000, but increases to 1:17,400 when combined with an apparently asymptomatic form of PA identified through newborn screening .The highest reported birth incidence is found among the Greenlandic Inuits: 1:1000 .Differential DiagnosisElevated C3 (propionylcarnitine) on newborn screening can be caused by methylmalonic acidemias resulting from methylmalonyl-CoA mutase deficiency, disorders of intracellular cobalamin metabolism and maternal B12 deficiency.The presence of elevated 3-hydroxypropionic with or without methylcitric acid on the urine organic acid assay should prompt additional diagnostic considerations:Multiple carboxylase deficiency (biotinidase and holocarboxylase synthetase deficiencies), which also shows elevation of lactic acid, 3-hydroxyvaleric acid and 3-methylcrotonylglycine caused | [
0.0973084419965744,
0.004954596050083637,
-0.06840868294239044,
-0.27786338329315186,
0.1593514233827591,
-0.007285383064299822,
-0.056297898292541504,
-0.3270207345485687,
0.14259971678256989,
-0.013168422505259514,
0.11320219933986664,
0.08559273928403854,
-0.0778036117553711,
0.04195268452167511,
-0.12971363961696625,
0.17588099837303162,
0.1333123743534088,
-0.06702257692813873,
-0.09333660453557968,
-0.12939463555812836,
0.0552145279943943,
-0.10653876513242722,
-0.26500239968299866,
0.10814265161752701,
0.2258252054452896,
-0.1745341420173645,
-0.018101651221513748,
-0.25755324959754944,
0.1531994789838791,
0.09143874794244766,
-0.20620180666446686,
-0.14091043174266815,
0.18286272883415222,
-0.07852529734373093,
0.007445735391229391,
-0.04494668170809746,
-0.07994333654642105,
-0.4377245604991913,
0.09944843500852585,
-0.18794046342372894,
0.10945054143667221,
-0.1373547464609146,
0.2264503836631775,
0.06797805428504944,
0.04689368978142738,
-0.11493941396474838,
0.10914058983325958,
-0.028764983639121056,
-0.09420932084321976,
0.2062874287366867,
0.24807707965373993,
-0.2694617807865143,
-0.34726306796073914,
0.061044275760650635,
0.18102803826332092,
-0.11660102754831314,
-0.2749970853328705,
-0.047354523092508316,
-0.08298439532518387,
0.18714240193367004,
0.15940622985363007,
0.04096221551299095,
0.060993459075689316,
-0.34602031111717224,
0.1683487594127655,
-0.09118738770484924,
0.058105967938899994,
0.3181288540363312,
0.3017297685146332,
0.043072596192359924,
0.05104927718639374,
0.054026585072278976,
-0.027365395799279213,
0.030498381704092026,
-0.17844288051128387,
0.05081817880272865,
0.1428341567516327,
-0.0226408913731575,
-0.016621720045804977,
-0.20176354050636292,
-0.2824264466762543,
0.06533540785312653,
0.07919953763484955,
0.09297539293766022,
-0.23090356588363647,
-0.1128295361995697,
0.15029630064964294,
0.0895254984498024,
-0.2748907804489136,
-0.02706143446266651,
0.03396036848425865,
-0.07149898260831833,
0.14268799126148224,
-0.08591759204864502,
0.28870636224746704,
-0.22769565880298615,
0.31641140580177307,
0.03042645752429962,
-0.1344774067401886,
0.07736880332231522,
0.09894168376922607,
0.09142733365297318,
-0.1758127212524414,
-0.1594267338514328,
-0.19059333205223083,
0.07474091649055481,
-0.04606953263282776,
-0.03183718025684357,
-0.04970810189843178,
0.02405443787574768,
0.21875524520874023,
-0.16563740372657776,
0.05186536908149719,
0.0888238325715065,
-0.4613111913204193,
0.08332128077745438,
-0.07756606489419937,
0.22397936880588531,
-0.0016578446375206113,
-0.12264363467693329,
-0.12811605632305145,
-0.19323650002479553,
0.08331876993179321,
0.24191825091838837,
-0.0173806045204401,
0.03888998180627823,
0.0488821342587471,
-0.1668628603219986,
0.3687797486782074,
-0.13447128236293793,
0.20746776461601257,
0.07193133234977722,
0.0036818108055740595,
-0.27420148253440857,
0.33948835730552673,
0.15899558365345,
-0.3083931505680084,
-0.2913113236427307,
0.035346195101737976,
0.05910700559616089,
0.16315630078315735,
0.15575993061065674,
0.1369403451681137,
0.19686469435691833,
0.2994542717933655,
-0.018307507038116455,
0.10620340704917908,
-0.05277720466256142,
0.27031272649765015,
0.009653860703110695,
0.04551074653863907,
-0.45764246582984924,
-0.0866752415895462,
-0.015478613786399364,
-0.16068176925182343,
0.13159848749637604,
0.07905178517103195,
0.28284457325935364,
0.03428749367594719,
0.0013590093003585935,
-0.02769109420478344,
-0.013290260918438435,
-0.09816440939903259,
0.032340336591005325,
-0.14531464874744415,
0.11963771283626556,
-0.3227958679199219,
0.013489379547536373,
-0.004853325430303812,
-0.015213249251246452,
-0.04199234023690224,
-0.03935050219297409,
-0.036117397248744965,
-0.02878781035542488,
0.34185001254081726,
0.014924450777471066,
0.009830892086029053,
-0.01550811156630516,
0.03288699686527252,
0.06760959327220917,
0.12146764248609543,
0.03606772422790527,
-0.22798381745815277,
-0.056052371859550476,
-0.06619182974100113,
-0.23234833776950836,
0.07238274067640305,
-0.03583160415291786,
-0.04111601412296295,
0.06917966902256012,
0.11675266921520233,
-0.027734162285923958,
0.014724938198924065,
0.06690795719623566,
0.023367609828710556,
-0.34269773960113525,
0.19892214238643646,
-0.036442872136831284,
0.0036742694210261106,
-0.08484575897455215,
0.09955105185508728,
-0.25451624393463135,
0.24810458719730377,
-0.08838482946157455,
-0.05717197805643082,
-0.038617249578237534,
0.09168317168951035,
-0.2050783932209015,
0.061825208365917206,
0.09232352674007416,
-0.13113991916179657,
0.23586970567703247,
-0.29229897260665894,
0.0002896531077567488,
-0.30614030361175537,
-0.07822755724191666,
0.10090786218643188,
-0.24908170104026794,
0.011907165870070457,
0.3587808907032013,
0.042090293020009995,
0.09386654198169708,
-0.015715811401605606,
-0.2541777491569519,
0.07695194333791733,
0.13259561359882355,
-0.27698031067848206,
-0.24292178452014923,
0.11834079027175903,
-0.14665642380714417,
-0.14933869242668152,
0.00027145020430907607,
0.0031432746909558773,
0.2367413341999054,
-0.09863859415054321,
-0.42639869451522827,
-0.3336135149002075,
0.18729069828987122,
-0.10085290670394897,
0.046336304396390915,
-0.3432652950286865,
-0.0269404835999012,
-0.03796114772558212,
0.07472290098667145,
-0.054436441510915756,
0.10536821186542511,
-0.11375453323125839,
-0.15396088361740112,
-0.08715521544218063,
0.01016402430832386,
0.06625857949256897,
0.19696953892707825,
-0.1088123694062233,
-0.014643153175711632,
-0.3971587121486664,
-0.2982403039932251,
0.21443045139312744,
0.057103805243968964,
-0.02915991097688675,
-0.047725167125463486,
0.025834178552031517,
0.1452769637107849,
0.03364932909607887,
0.18150494992733002,
-0.17271800339221954,
-0.07824866473674774,
-0.21541689336299896,
-0.06128469482064247,
-0.07766982167959213,
-0.23007789254188538,
-0.07076631486415863,
0.08348366618156433,
0.22349992394447327,
0.13529539108276367,
-0.0390545129776001,
-0.17074866592884064,
0.0721588134765625,
0.0026047369465231895,
-0.15156953036785126,
0.027257775887846947,
-0.1968916654586792,
0.2586713433265686,
-0.09683317691087723,
0.16845883429050446,
0.3157522678375244,
0.11256624758243561,
-0.19908063113689423,
0.20919659733772278,
-0.1937483549118042,
0.09495466202497482,
0.10828933864831924,
0.12129567563533783,
-0.15974704921245575,
-0.20674879848957062,
0.2343399077653885,
0.18986427783966064,
-0.11872021853923798,
-0.1112021654844284,
0.014788631349802017,
0.2663346827030182,
-0.01450134813785553,
-0.00255762436427176,
-0.02895098552107811,
-0.18897773325443268,
-0.26357215642929077,
0.07495948672294617,
-0.20066316425800323,
-0.20306645333766937,
0.028892280533909798,
0.24516285955905914,
-0.09454552084207535,
0.03370979428291321,
-0.2223898321390152,
-0.03982209786772728,
0.07205583900213242,
-0.1609136313199997,
0.3816298544406891,
0.13744103908538818,
0.1788364201784134,
0.2715337574481964,
0.1614455133676529,
-0.011908357962965965,
0.1623847484588623,
0.10325264930725098,
-0.26098960638046265,
-0.08081813156604767,
-0.09468685835599899,
-0.08671946823596954,
-0.10552087426185608,
-0.10478536784648895,
0.33673524856567383,
0.13126544654369354,
-0.2975400686264038,
-0.07042361795902252,
0.2957606315612793,
0.1282845288515091,
0.45843663811683655,
0.03524795547127724,
-0.14009705185890198,
-0.07812051475048065,
0.27161380648612976,
-0.37705910205841064,
0.09094434976577759,
-0.2311324030160904,
-0.2585006356239319,
0.027174877002835274,
0.014712845906615257,
0.19391368329524994,
0.036201417446136475,
-0.1604907214641571,
0.05061206594109535,
0.09891346096992493,
-0.05513841286301613,
-0.11181841790676117,
0.4147026538848877,
-0.11391284316778183,
-0.13352151215076447,
0.05614841356873512,
0.13578839600086212,
-0.0417323112487793,
-0.23583854734897614,
-0.012756084091961384,
-0.005060953553766012,
-0.1254773885011673,
0.02559937722980976,
-0.16136056184768677,
-0.10199087113142014,
0.174225851893425,
0.11545007675886154,
0.01880146563053131,
0.09501270204782486,
0.14883659780025482,
0.12271969765424728,
0.15510651469230652,
0.04622766748070717,
0.1280832290649414,
0.027006249874830246,
0.09754255414009094,
-0.2942972183227539,
-0.17049092054367065,
-0.028672823682427406,
0.12210408598184586,
-0.004203638061881065,
0.007348041050136089,
-0.03748773783445358,
0.2427343875169754,
-0.01830257475376129,
0.13724225759506226,
0.2850814759731293,
-0.47503232955932617,
0.08857356011867523,
0.10570845752954483,
0.13842709362506866,
0.17860685288906097,
0.1696288287639618,
0.18028508126735687,
-0.0012781444238498807,
-0.08263576030731201,
-0.10624255239963531,
0.1177615076303482,
0.021966373547911644,
0.16319751739501953,
0.22715312242507935,
0.26190951466560364,
0.06148484721779823,
0.254331111907959,
-0.023906884714961052,
0.07693149149417877,
-0.11882110685110092,
-0.09841704368591309,
-0.0030502590816468,
-0.004666976630687714,
-0.06723947077989578,
-0.10312940925359726,
-0.18041469156742096,
-0.1930692046880722,
-0.18891285359859467,
0.04050971195101738,
0.11461681872606277,
-0.014767328277230263,
0.026727650314569473,
0.15227051079273224,
0.03490278497338295,
-0.08532548695802689,
-0.20366919040679932,
-0.025210963562130928,
0.06780704110860825,
0.06828644126653671,
0.2001742720603943,
0.13213993608951569,
0.15588721632957458,
0.09366551041603088,
-0.004829175770282745,
0.0332503579556942,
-0.09203806519508362,
0.0350189134478569,
-0.3474094569683075,
-0.0036719543859362602,
-0.07871080189943314,
-0.1538577377796173,
0.25611528754234314,
0.03766162693500519,
-0.2961984872817993,
0.02763436920940876,
-0.17527857422828674,
0.23902545869350433,
0.2519932687282562,
0.38341403007507324,
0.026820603758096695,
0.13581582903862,
0.14829325675964355,
-0.04915681481361389,
0.021385621279478073,
0.006597386207431555,
0.12913982570171356,
-0.10321181267499924,
-0.014340762980282307,
-0.03215894475579262,
0.06044777110219002,
-0.2397044450044632,
-0.14635330438613892,
0.16050678491592407,
0.36923545598983765,
-0.07162896543741226,
-0.22799618542194366,
0.09422878175973892,
-0.08716639876365662,
-0.048312291502952576,
0.08021371811628342,
-0.07870720326900482,
0.03765207529067993,
0.06311047822237015,
-0.15298467874526978,
-0.05729873478412628,
-0.21093885600566864,
0.03459203615784645,
-0.04529135674238205,
-0.03266266733407974,
0.16138747334480286,
0.26097601652145386,
0.058226026594638824,
-0.10220032930374146,
-0.07523512095212936,
-0.10947258770465851,
-0.2117747962474823,
0.08904699981212616,
-0.12553493678569794,
-0.1427871286869049,
0.3789883852005005,
-0.008702171966433525,
0.07322121411561966,
0.2420157641172409,
0.0842536985874176,
0.39426228404045105,
-0.1659875214099884,
-0.17251688241958618,
-0.08126550167798996,
-0.0667511597275734,
-0.11729700863361359,
0.09192105382680893,
-0.13793697953224182,
-0.0994696095585823,
-0.0808047354221344,
0.13890500366687775,
0.0633755773305893,
0.05678321793675423,
-0.03457681089639664,
-0.11591930687427521,
0.10040313005447388,
0.20949788391590118,
0.03609878197312355,
0.05202217027544975,
-0.01552934106439352,
-0.18993306159973145,
0.08271415531635284,
-0.2237427979707718,
0.28617629408836365,
0.19505026936531067,
0.02178175561130047,
-0.3825434446334839,
0.10745426267385483,
-0.1773591935634613,
0.30011165142059326,
-0.05413258075714111,
0.1038689911365509,
-0.1717439442873001,
0.07527874410152435,
0.2942467927932739,
0.0612562894821167,
-0.16216601431369781,
0.11693271994590759,
-0.08476816862821579,
-0.3254759609699249,
0.027512097731232643,
0.36339521408081055,
-0.18112340569496155,
-0.10805810242891312,
-0.24733901023864746,
0.06182282045483589,
-0.1318606436252594,
0.036970723420381546,
-0.15020552277565002,
0.03607833385467529,
-0.1425398588180542,
-0.45216885209083557,
0.2797527611255646,
0.1778581291437149,
0.19131743907928467,
0.11434447765350342,
-0.18523328006267548,
-0.1361108273267746,
-0.3077158033847809,
0.14549541473388672,
0.006324049551039934,
0.2019466608762741,
-0.2427169531583786,
-0.03589005395770073,
-0.3702954053878784,
-0.060397107154130936,
-0.06149753928184509,
-0.15659846365451813,
-0.08722898364067078,
-0.2831975519657135,
0.12695062160491943,
-0.13961631059646606,
0.1656157374382019,
-0.1513044387102127,
-0.017254116013646126,
-0.1427760124206543,
-0.3570302724838257,
0.05655928701162338,
-0.013612465932965279,
0.06629922240972519,
-0.13131646811962128,
-0.07009054720401764,
0.0766323059797287,
-0.1023607924580574,
-0.5163195729255676,
-0.12885352969169617,
0.13947069644927979,
-0.07989007979631424,
-0.2740277945995331,
0.23618976771831512,
-0.04052387550473213,
0.12221372872591019,
-0.06944936513900757,
0.1662214696407318,
0.1213984563946724,
0.16775067150592804,
-0.0666346624493599,
0.03103029914200306,
-0.23983421921730042,
0.07815242558717728,
0.004084023181349039,
-0.010325179435312748,
-0.2626764476299286,
0.09437329322099686,
0.04424893110990524,
0.24977007508277893,
0.05744350701570511,
0.22206644713878632,
0.165035218000412,
-0.11830269545316696,
-0.22961080074310303,
-0.126642644405365,
0.13967612385749817,
0.38300657272338867,
-0.28821489214897156,
-0.00047823999193497,
-0.049054138362407684,
-0.027686765417456627,
0.0917719304561615,
0.11181648075580597,
-0.0007611368782818317,
0.08721031993627548,
-0.03523370623588562,
0.1309376209974289,
0.13217276334762573,
0.24563796818256378,
-0.15043947100639343,
0.4332039952278137,
0.049324505031108856,
0.18623346090316772,
-0.11790155619382858,
-0.11182475090026855,
0.2325637936592102,
0.0949590727686882,
-0.11163758486509323,
0.12987962365150452,
0.02518199384212494,
0.17521022260189056,
0.2513633370399475,
-0.07093213498592377,
-0.04163246974349022,
-0.22636666893959045,
0.16861318051815033,
0.20786404609680176,
-0.05179775878787041,
-0.10749150067567825,
0.04993274435400963,
-0.12834757566452026,
0.02142845094203949,
-0.13271035254001617,
0.2166554480791092,
-0.3496476113796234,
0.143467515707016,
-0.02297194115817547,
-0.26089373230934143,
-0.18093159794807434,
-0.19071358442306519,
0.181017205119133,
-0.1020040437579155,
0.014039067551493645,
0.08394823968410492,
0.2955300509929657,
-0.17196182906627655,
0.17829400300979614,
-0.24035058915615082,
0.2881587743759155,
-0.3101416230201721,
-0.0014563434524461627,
0.04613908380270004,
0.22016911208629608,
-0.032344259321689606,
-0.01346890814602375,
0.43464627861976624,
0.23045216500759125,
-0.11700661480426788,
0.07626384496688843,
-0.29856452345848083,
-0.31269189715385437,
-0.0951419323682785,
0.04519648849964142,
0.11677403748035431,
0.15882158279418945,
-0.05623304843902588,
-0.2798081040382385,
0.33093327283859253,
-0.01746508851647377,
0.4344419538974762,
0.15810741484165192,
-0.38459667563438416,
-0.2738044559955597,
-0.015898272395133972,
0.012127210386097431,
0.1158566102385521,
0.1628401279449463,
-0.14830157160758972,
0.3261178433895111,
-0.17989596724510193,
-0.03325704485177994,
-0.02777763269841671,
0.23161788284778595,
0.1679549515247345,
-0.02271786518394947,
-0.00733738811686635,
0.38622212409973145,
-0.21526922285556793,
-0.3375644087791443,
0.0054276431910693645,
-0.10244966298341751,
0.0968092754483223,
0.15086208283901215,
0.10779295116662979,
-0.2348581999540329,
-0.06146177649497986,
0.16128741204738617,
-0.010510319843888283,
0.05236012861132622,
-0.137696772813797,
-0.28839531540870667,
-0.1530493199825287,
-0.09720862656831741,
0.26314815878868103,
-0.20138055086135864,
0.2692086696624756,
-0.06990805268287659,
0.08827010542154312,
-0.11979445815086365,
-0.23172102868556976,
-0.00310061895288527,
0.18852020800113678,
-0.028004249557852745,
-0.0681004747748375,
0.04654319956898689,
0.1359676867723465,
-0.2359447181224823,
0.0988454818725586,
0.06132659688591957,
0.06137356907129288,
-0.2670847773551941,
0.1198652908205986,
-0.5091958045959473,
-0.09558703750371933,
-0.028640007600188255,
0.0914544016122818,
-0.10148096084594727,
0.016170913353562355,
-0.14428262412548065,
-0.2630135118961334,
-0.010387087240815163,
0.16578702628612518,
0.2265750616788864,
-0.10057739913463593,
-0.04421994462609291,
0.17217400670051575,
0.0009842104045674205,
-0.21712446212768555,
-0.2553991973400116,
-0.13475292921066284,
0.11372106522321701,
0.34948185086250305,
0.11271710693836212,
-0.11353336274623871,
0.06914783269166946,
0.05460004135966301,
-0.022987641394138336,
-0.04997151345014572,
0.03342599794268608,
-0.09646576642990112,
-0.36507341265678406,
-0.029464108869433403,
-0.10785642266273499,
0.04259071126580238,
0.026174772530794144,
0.2776942849159241,
0.1632121205329895,
-0.08296540379524231
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. on newborn screening can be caused by methylmalonic acidemias resulting from methylmalonyl-CoA mutase deficiency, disorders of intracellular cobalamin metabolism and maternal B12 deficiency.The presence of elevated 3-hydroxypropionic with or without methylcitric acid on the urine organic acid assay should prompt additional diagnostic considerations:Multiple carboxylase deficiency (biotinidase and holocarboxylase synthetase deficiencies), which also shows elevation of lactic acid, 3-hydroxyvaleric acid and 3-methylcrotonylglycine caused by defective activity of pyruvate carboxylase, propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylaseMethylmalonic acidemias, which have elevations of 2-methylcitric acid and 3-hydroxypropionic acid, and additionally show elevations of methylmalonic acid. Cobalamin C, D, and F metabolism defects result in abnormal homocysteine metabolism. Total plasma homocysteine can help in the diagnostic workup of individuals ascertained with elevated propionylcarnitine.Maternal B12 | [
0.02385811321437359,
-0.10855205357074738,
-0.07267182320356369,
-0.25418344140052795,
0.1485641896724701,
0.044586822390556335,
-0.16803601384162903,
-0.2519453167915344,
0.21128876507282257,
-0.02918247878551483,
0.2577941417694092,
0.002544962801039219,
0.007904978469014168,
0.022467991337180138,
-0.08350447565317154,
0.13503339886665344,
0.03866501897573471,
-0.10606177151203156,
-0.08219963312149048,
-0.10396262258291245,
-0.11342623084783554,
-0.02708487957715988,
-0.3063255548477173,
0.11227817833423615,
0.20005075633525848,
-0.19384270906448364,
0.04219312220811844,
-0.2814234495162964,
0.16170185804367065,
-0.00509194191545248,
-0.25846007466316223,
-0.19824238121509552,
0.24770119786262512,
0.025505004450678825,
0.06805944442749023,
-0.1273423582315445,
-0.13082416355609894,
-0.5157094597816467,
0.12455443292856216,
-0.0556851327419281,
0.03929109126329422,
-0.18351636826992035,
0.21052208542823792,
-0.04105618968605995,
0.10522560775279999,
-0.17253871262073517,
0.01079726591706276,
-0.1172817125916481,
-0.00951762218028307,
0.19486048817634583,
0.24434314668178558,
-0.24130478501319885,
-0.37733128666877747,
0.01811772771179676,
0.25538966059684753,
-0.1599229872226715,
-0.31453531980514526,
0.004693253431469202,
-0.21266980469226837,
0.35985055565834045,
0.30275219678878784,
0.10130339115858078,
0.05617237836122513,
-0.34546151757240295,
0.14852558076381683,
-0.21095918118953705,
0.19028542935848236,
0.4593336880207062,
0.4969841241836548,
0.12103864550590515,
-0.03167330101132393,
-0.08468250185251236,
0.013683191500604153,
0.10933324694633484,
-0.07867823541164398,
-0.008241063915193081,
0.15407118201255798,
0.007309495471417904,
0.042680226266384125,
-0.06871489435434341,
-0.2127525359392166,
0.029761653393507004,
0.11943972855806351,
0.01754954271018505,
-0.2683682143688202,
-0.1310410350561142,
0.06832309812307358,
0.13200689852237701,
-0.15374185144901276,
-0.14266806840896606,
0.12609291076660156,
-0.04605652019381523,
0.25390636920928955,
0.048340167850255966,
0.2610495388507843,
-0.2643461525440216,
0.4455118179321289,
0.13285940885543823,
-0.19249461591243744,
0.12251913547515869,
0.0851001963019371,
0.023739542812108994,
-0.20178766548633575,
-0.14582403004169464,
-0.27024829387664795,
0.030732110142707825,
-0.04652843251824379,
-0.14804892241954803,
-0.23549947142601013,
-0.12246903777122498,
0.2089690864086151,
-0.1414746195077896,
0.03094705566763878,
0.03811462223529816,
-0.43833741545677185,
-0.02542882412672043,
-0.006597990170121193,
0.11008035391569138,
0.04640263691544533,
-0.10728323459625244,
-0.09212535619735718,
-0.21538209915161133,
0.18099024891853333,
0.35948479175567627,
-0.025200385600328445,
0.003599694697186351,
0.005085183307528496,
-0.1429143100976944,
0.4274008572101593,
-0.02026757225394249,
0.22161804139614105,
0.09413237124681473,
-0.08927927911281586,
-0.2560431957244873,
0.34017932415008545,
0.23384997248649597,
-0.334946870803833,
-0.2990134060382843,
0.033787209540605545,
0.16696393489837646,
0.17274171113967896,
0.03984791785478592,
0.15573155879974365,
0.1496473252773285,
0.34219732880592346,
-0.11578059941530228,
0.14126163721084595,
0.011735357344150543,
0.18303202092647552,
-0.051605649292469025,
-0.001619557267986238,
-0.5374628305435181,
-0.20522579550743103,
-0.03215603157877922,
-0.20411260426044464,
0.21968840062618256,
0.1193135604262352,
0.22799602150917053,
0.06916072219610214,
-0.036792803555727005,
-0.02424410916864872,
-0.1307927519083023,
-0.09423743188381195,
0.018363788723945618,
-0.19721126556396484,
0.07081993669271469,
-0.29024437069892883,
-0.05396367982029915,
0.037410933524370193,
-0.0985974445939064,
-0.15047796070575714,
-0.01471177488565445,
0.00436258502304554,
0.04203786328434944,
0.4043959677219391,
0.005596319679170847,
0.14083179831504822,
-0.05412433668971062,
-0.0017736338777467608,
0.0898173600435257,
0.15309089422225952,
0.06641661375761032,
-0.15593641996383667,
0.0708092749118805,
-0.017420977354049683,
-0.16534523665905,
-0.09351440519094467,
0.023844989016652107,
-0.002244018716737628,
0.02670389413833618,
0.1318669617176056,
0.05007661506533623,
0.13014402985572815,
0.004132589790970087,
0.05319757014513016,
-0.30951109528541565,
0.26285213232040405,
0.1303454339504242,
0.06649786978960037,
-0.1168413758277893,
0.22616836428642273,
-0.23195385932922363,
0.18572461605072021,
-0.13356749713420868,
-0.1247997060418129,
0.08501575142145157,
0.08712789416313171,
-0.24979110062122345,
0.08137035369873047,
0.1773446500301361,
-0.26454392075538635,
0.18136459589004517,
-0.2853015065193176,
0.049340903759002686,
-0.21897797286510468,
0.021052833646535873,
0.00702495826408267,
-0.23463144898414612,
0.020492957904934883,
0.43131396174430847,
0.1536434292793274,
0.11221033334732056,
0.03143453225493431,
-0.30145418643951416,
0.0039191097021102905,
0.13907785713672638,
-0.19977323710918427,
-0.28346556425094604,
0.06017472594976425,
-0.051849592477083206,
-0.25212472677230835,
-0.05213221162557602,
-0.08673860132694244,
0.18821191787719727,
-0.07942963391542435,
-0.5140666961669922,
-0.3055651783943176,
0.15081787109375,
-0.044144924730062485,
-0.05539388209581375,
-0.2576337158679962,
-0.1423346996307373,
-0.15059202909469604,
0.1979047656059265,
-0.05775102227926254,
0.16392837464809418,
-0.056041136384010315,
-0.07974141091108322,
-0.11336648464202881,
0.05620102211833,
0.01626143790781498,
0.14576947689056396,
-0.03172268345952034,
0.015613817609846592,
-0.36516425013542175,
-0.1594158411026001,
0.2556193172931671,
0.10162477195262909,
-0.0812944620847702,
-0.09196402877569199,
-0.0015807475429028273,
0.10678654909133911,
0.013675863854587078,
0.17362158000469208,
-0.2083861529827118,
-0.08825154602527618,
-0.2298901379108429,
-0.04252820089459419,
-0.07888847589492798,
-0.1576635092496872,
-0.09321295469999313,
0.0679689571261406,
0.2609134316444397,
0.16363048553466797,
-0.03208138048648834,
-0.2490679770708084,
0.12793107330799103,
-0.019594870507717133,
-0.22751133143901825,
0.07584062218666077,
-0.2269717901945114,
0.32889339327812195,
-0.12938395142555237,
0.14337261021137238,
0.3489481210708618,
0.13036489486694336,
-0.20206551253795624,
0.06469430029392242,
-0.21747730672359467,
0.052184924483299255,
0.12327844649553299,
0.07507101446390152,
-0.2472187578678131,
-0.35717588663101196,
0.2805251479148865,
0.14389413595199585,
-0.10678699612617493,
-0.08891226351261139,
0.0377197302877903,
0.25588271021842957,
-0.006676897406578064,
0.06967397034168243,
-0.025220081210136414,
-0.18256822228431702,
-0.3272346556186676,
0.08069852739572525,
-0.23040907084941864,
-0.23761972784996033,
0.04576138034462929,
0.1833927035331726,
-0.11286953091621399,
0.10235052555799484,
-0.3548378050327301,
-0.18995065987110138,
0.049848806113004684,
-0.15124352276325226,
0.432366281747818,
0.08163733780384064,
0.1838042289018631,
0.17015530169010162,
0.059486761689186096,
-0.012768778949975967,
0.14039374887943268,
0.1828364133834839,
-0.19011536240577698,
-0.1462530791759491,
-0.06462337076663971,
-0.07639279961585999,
-0.12352501600980759,
-0.14056099951267242,
0.24605517089366913,
0.1544732302427292,
-0.2473972886800766,
-0.13107289373874664,
0.3533267676830292,
0.10457184910774231,
0.5285645723342896,
0.0940166562795639,
-0.12735749781131744,
-0.16018417477607727,
0.2814587354660034,
-0.4252219796180725,
0.16839683055877686,
-0.2106340080499649,
-0.15898391604423523,
0.07310917228460312,
-0.047927726060152054,
0.24294158816337585,
-0.09315843880176544,
-0.17857635021209717,
-0.017425300553441048,
0.034834783524274826,
-0.13552497327327728,
-0.16417096555233002,
0.439767450094223,
-0.005135047249495983,
-0.21247518062591553,
0.11838757246732712,
0.17483939230442047,
-0.16669322550296783,
-0.22334398329257965,
0.14646324515342712,
-0.1068333089351654,
-0.11883365362882614,
-0.02535656839609146,
-0.265120267868042,
-0.13575848937034607,
0.16008639335632324,
0.15097181499004364,
0.12446743994951248,
0.0034764662850648165,
0.17958953976631165,
0.13907679915428162,
0.20592465996742249,
-0.020064659416675568,
0.039226967841386795,
-0.08546599745750427,
0.08963090926408768,
-0.15476487576961517,
-0.015331476926803589,
-0.07558363676071167,
0.15057149529457092,
0.008534877561032772,
0.09065399318933487,
-0.18194250762462616,
0.29751721024513245,
-0.028171563521027565,
0.19321249425411224,
0.30036622285842896,
-0.5498571991920471,
0.12946717441082,
0.05666302517056465,
0.18968982994556427,
0.17245569825172424,
0.09786181151866913,
0.1505875289440155,
-0.02907322533428669,
-0.02566167339682579,
-0.11325222253799438,
0.055580850690603256,
0.029773231595754623,
0.014252420514822006,
0.2739173173904419,
0.29682809114456177,
0.005456767976284027,
0.29058554768562317,
0.0949152484536171,
0.12706147134304047,
-0.09907552599906921,
-0.029091980308294296,
-0.0046303425915539265,
-0.034088652580976486,
-0.05388326942920685,
-0.043221935629844666,
-0.21995136141777039,
-0.17061707377433777,
-0.10966794192790985,
0.12173017859458923,
0.16079895198345184,
-0.010778252966701984,
-0.0596521757543087,
0.3097188472747803,
0.04163559153676033,
-0.0595504529774189,
-0.1712554544210434,
-0.1447550505399704,
-0.0021462347358465195,
0.03382783383131027,
0.25703901052474976,
0.06800778210163116,
0.09375478327274323,
0.12887786328792572,
0.02797502838075161,
0.06990350037813187,
-0.09333498775959015,
0.05926639586687088,
-0.3286033570766449,
-0.06569439172744751,
-0.08312706649303436,
-0.1910548061132431,
0.22095966339111328,
0.039120085537433624,
-0.24286840856075287,
-0.018038082867860794,
-0.11841057986021042,
0.2702077627182007,
0.26685312390327454,
0.5228739976882935,
0.04091585427522659,
0.044113755226135254,
0.11535844951868057,
-0.10191363096237183,
0.11142387986183167,
0.17010848224163055,
0.20979496836662292,
-0.13205966353416443,
-0.04082383215427399,
0.08120466768741608,
0.027309542521834373,
-0.2941252589225769,
-0.20944306254386902,
0.20707394182682037,
0.2903815507888794,
-0.14548207819461823,
-0.18977388739585876,
0.09195903688669205,
-0.07333068549633026,
-0.08343879878520966,
0.11800362169742584,
-0.15524359047412872,
0.1013961136341095,
0.11920671910047531,
-0.18405576050281525,
-0.07850761711597443,
-0.31453508138656616,
0.049009911715984344,
-0.09041018038988113,
-0.02596971206367016,
0.3080174922943115,
0.22834806144237518,
0.02381392940878868,
-0.22777330875396729,
-0.12546135485172272,
-0.09660325944423676,
-0.18162362277507782,
0.000648324959911406,
-0.12943591177463531,
-0.22636817395687103,
0.3395538330078125,
-0.0709410235285759,
0.16531434655189514,
0.2006060779094696,
-0.031568095088005066,
0.3861519992351532,
-0.18281587958335876,
-0.1783275157213211,
-0.08244054764509201,
0.013719054870307446,
-0.11536557972431183,
-0.016790341585874557,
-0.19872188568115234,
-0.026627881452441216,
-0.18572412431240082,
0.11819875240325928,
0.06743243336677551,
0.07314445078372955,
0.0392795093357563,
-0.2074420005083084,
0.04993380233645439,
0.31257230043411255,
0.10785563290119171,
0.02620796300470829,
0.1332719624042511,
-0.24138501286506653,
0.13748103380203247,
-0.3218390941619873,
0.37978458404541016,
0.21695980429649353,
0.04059433937072754,
-0.2611299753189087,
0.07453419268131256,
-0.26874327659606934,
0.2676146626472473,
-0.09084200859069824,
0.22892233729362488,
-0.11555102467536926,
0.14774839580059052,
0.3786851167678833,
0.11243879050016403,
-0.08270774781703949,
0.15249809622764587,
-0.08833272755146027,
-0.2667841911315918,
-0.025930285453796387,
0.32846760749816895,
-0.20634132623672485,
-0.13225524127483368,
-0.24871930480003357,
0.10624290257692337,
-0.24020890891551971,
0.0993271917104721,
-0.200091153383255,
-0.0631711408495903,
-0.16296075284481049,
-0.5420880317687988,
0.29596537351608276,
0.1980213224887848,
0.28748399019241333,
0.1065012738108635,
-0.2189866453409195,
-0.12094399333000183,
-0.32365697622299194,
0.1571110486984253,
-0.07727546244859695,
0.27603578567504883,
-0.14586706459522247,
0.054252512753009796,
-0.399167537689209,
-0.11471601575613022,
-0.08617479354143143,
-0.14812244474887848,
-0.03623805567622185,
-0.28748032450675964,
0.1188497543334961,
-0.037124551832675934,
0.1737898588180542,
-0.1769464612007141,
-0.00020143002620898187,
-0.08370177447795868,
-0.42265161871910095,
0.08385021984577179,
0.1646285206079483,
0.14689673483371735,
-0.13817118108272552,
-0.07425250113010406,
0.03948579356074333,
-0.05732486769556999,
-0.42830774188041687,
-0.14017169177532196,
0.12227078527212143,
-0.12108255177736282,
-0.3412594497203827,
0.19580787420272827,
-0.047287434339523315,
0.19035348296165466,
-0.10936055332422256,
0.09147999435663223,
0.07400614768266678,
0.2782996892929077,
0.010434981435537338,
0.019145678728818893,
-0.272675484418869,
0.03979645296931267,
-0.014159214682877064,
0.027960678562521935,
-0.36430832743644714,
0.0947960913181305,
-0.003549356246367097,
0.2884547710418701,
0.06340304017066956,
0.14395274221897125,
0.248652845621109,
-0.2949126064777374,
-0.35232093930244446,
-0.18399465084075928,
0.2699741721153259,
0.3709073066711426,
-0.23373857140541077,
-0.03940562158823013,
-0.040367625653743744,
-0.1237049251794815,
0.05447251722216606,
0.11762229353189468,
-0.01471797376871109,
0.07196880877017975,
-0.10838817805051804,
0.0583350695669651,
0.17619085311889648,
0.20524567365646362,
-0.1303645521402359,
0.41009682416915894,
0.00975783821195364,
0.19792021811008453,
-0.1351507008075714,
-0.06593688577413559,
0.26961421966552734,
0.16635824739933014,
-0.11812906712293625,
0.107011578977108,
0.1395859569311142,
0.37081828713417053,
0.23780710995197296,
-0.0847216472029686,
-0.0039245556108653545,
-0.28165552020072937,
0.12541718780994415,
0.30772286653518677,
-0.05065752565860748,
-0.16165710985660553,
0.09361298382282257,
-0.05771998316049576,
-0.03850604221224785,
-0.20584464073181152,
0.2911355793476105,
-0.3670285940170288,
0.17878025770187378,
-0.022110527381300926,
-0.3339558243751526,
-0.2790417969226837,
-0.21851930022239685,
0.19348019361495972,
-0.04622681811451912,
-0.06575404852628708,
0.0304978359490633,
0.37775468826293945,
-0.10408834367990494,
0.06547991186380386,
-0.19918866455554962,
0.3003689646720886,
-0.2913378179073334,
0.009050186723470688,
0.08055766671895981,
0.23793254792690277,
-0.12895886600017548,
0.022657781839370728,
0.4495643377304077,
0.2048325091600418,
-0.048951778560876846,
0.11899510771036148,
-0.27431318163871765,
-0.3364010453224182,
-0.22845558822155,
-0.01824011094868183,
0.33170461654663086,
0.22588510811328888,
-0.1071326956152916,
-0.2493429332971573,
0.2600519359111786,
-0.05944003909826279,
0.5045623183250427,
0.24475771188735962,
-0.37748655676841736,
-0.1811443567276001,
-0.11823741346597672,
0.05235188826918602,
0.11396943032741547,
0.19960811734199524,
-0.00901609193533659,
0.31610745191574097,
-0.09695681184530258,
-0.006048875395208597,
-0.09249309450387955,
0.32826539874076843,
0.1766529232263565,
-0.09010221809148788,
-0.055125921964645386,
0.41697990894317627,
-0.31132593750953674,
-0.29999399185180664,
0.05948708578944206,
-0.047917693853378296,
0.15588809549808502,
0.1515081822872162,
0.2310657948255539,
-0.2909128665924072,
-0.05424335226416588,
0.1458909660577774,
0.1787719875574112,
-0.013640796765685081,
-0.20794764161109924,
-0.368539035320282,
-0.09768667072057724,
-0.09306468814611435,
0.22999319434165955,
-0.24078474938869476,
0.13792935013771057,
-0.05557660758495331,
0.027645815163850784,
-0.0802735984325409,
-0.21637645363807678,
-0.09463328868150711,
0.2653133273124695,
0.07298345863819122,
-0.07395683974027634,
0.1916177123785019,
0.16661004722118378,
-0.25892964005470276,
0.20470380783081055,
0.0950753465294838,
0.07658007740974426,
-0.32336434721946716,
0.10283064842224121,
-0.5595247745513916,
-0.12597070634365082,
-0.08778349310159683,
-0.00172910385299474,
-0.12917932868003845,
0.017391618341207504,
-0.10112745314836502,
-0.3024905025959015,
0.045050255954265594,
0.2604092061519623,
0.1567574292421341,
-0.15999971330165863,
-0.06389882415533066,
0.28020718693733215,
0.027272941544651985,
-0.23271489143371582,
-0.22201019525527954,
0.030347926542162895,
0.19560639560222626,
0.3593863248825073,
0.07185312360525131,
-0.03863360732793808,
0.0282424408942461,
0.08163904398679733,
-0.05299048870801926,
-0.04669083654880524,
0.020913302898406982,
-0.02847742661833763,
-0.4282948970794678,
0.027881603688001633,
-0.049362488090991974,
0.04993227869272232,
0.0943954661488533,
0.308234840631485,
0.1882016807794571,
-0.07679744809865952
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. methylcrotonylglycine caused by defective activity of pyruvate carboxylase, propionyl-CoA carboxylase, and 3-methylcrotonyl-CoA carboxylaseMethylmalonic acidemias, which have elevations of 2-methylcitric acid and 3-hydroxypropionic acid, and additionally show elevations of methylmalonic acid. Cobalamin C, D, and F metabolism defects result in abnormal homocysteine metabolism. Total plasma homocysteine can help in the diagnostic workup of individuals ascertained with elevated propionylcarnitine.Maternal B12 deficiency identified through elevated propionylcarnitine on the newborn screen can also present with elevated urinary methylmalonic acid and total plasma homocysteine in infant. In maternal vitamin B12 deficiency, infant vitamin B12 levels can be in the normal range .Urine organic acid assay in individuals with carbonic anhydrase VA deficiency can reveal elevated 3-hydroxypropionic acid, propionylglycine, and methylcitric acid as well as 3-methylcrotonylglycine, 3-hydroxybutyric, alpha- | [
0.07970418781042099,
-0.16462844610214233,
-0.08158371597528458,
-0.32026568055152893,
0.14321397244930267,
0.1886802762746811,
-0.0566091351211071,
-0.06931784749031067,
0.08550065755844116,
-0.09620989859104156,
0.19098737835884094,
0.06880871206521988,
-0.009175916202366352,
0.055468812584877014,
-0.06957532465457916,
0.21116940677165985,
-0.11270809173583984,
0.011004053987562656,
-0.09412063658237457,
-0.15524044632911682,
0.05244958773255348,
-0.13970942795276642,
-0.21502900123596191,
0.20230969786643982,
0.24131345748901367,
-0.3836953341960907,
0.12667204439640045,
-0.23565511405467987,
0.2231118381023407,
0.03672434762120247,
-0.23566792905330658,
-0.242152601480484,
0.17404530942440033,
-0.025526585057377815,
0.053097810596227646,
-0.1561918556690216,
-0.05339133366942406,
-0.6788982152938843,
-0.03498358279466629,
-0.03737189993262291,
0.0631222128868103,
-0.035031840205192566,
0.11610142141580582,
-0.1162736788392067,
0.08354328572750092,
-0.3456748425960541,
0.020500548183918,
-0.18793903291225433,
-0.11123973876237869,
0.12037550657987595,
0.20311260223388672,
-0.33100563287734985,
-0.3708520531654358,
0.03341228887438774,
0.2141863852739334,
-0.04913495481014252,
-0.3345451354980469,
-0.02631280943751335,
-0.19606144726276398,
0.48356813192367554,
0.18960268795490265,
0.04752292484045029,
0.030147915706038475,
-0.3207653760910034,
0.07464957237243652,
-0.0450604073703289,
0.11452805995941162,
0.33875465393066406,
0.37871503829956055,
0.19825142621994019,
-0.015253611840307713,
-0.12353161722421646,
0.011398796923458576,
0.009051396511495113,
-0.1315717101097107,
0.055825892835855484,
0.06193040311336517,
-0.03632095828652382,
-0.05520598590373993,
-0.059484273195266724,
-0.05712365359067917,
0.20763354003429413,
-0.024766821414232254,
0.030454184859991074,
-0.26104724407196045,
-0.008473082445561886,
-0.14716693758964539,
0.07682891190052032,
-0.20542289316654205,
-0.036883048713207245,
0.21846070885658264,
0.02251293696463108,
0.15245108306407928,
-0.07211460173130035,
0.2055470198392868,
-0.22515973448753357,
0.4319400191307068,
0.037210479378700256,
-0.03785087913274765,
0.2038966566324234,
0.012787094339728355,
-0.08415396511554718,
-0.2538358271121979,
-0.16327625513076782,
-0.2899278402328491,
0.03939346224069595,
-0.11764662712812424,
0.011442157439887524,
-0.22637738287448883,
-0.17407846450805664,
0.2540268898010254,
0.005780375096946955,
0.05611521750688553,
0.11618148535490036,
-0.45179176330566406,
-0.10009926557540894,
-0.016002535820007324,
0.278878778219223,
0.15634706616401672,
0.16783787310123444,
-0.1387305110692978,
-0.1865871399641037,
0.11475149542093277,
0.4194199740886688,
-0.023241665214300156,
0.05823226273059845,
-0.10770367830991745,
-0.16579560935497284,
0.45678773522377014,
0.17272301018238068,
0.16387024521827698,
0.0022558141499757767,
-0.21292644739151,
-0.015811074525117874,
0.2670738101005554,
0.2092507779598236,
-0.2929081320762634,
-0.2631151080131531,
0.04520811885595322,
0.23761814832687378,
0.20409579575061798,
0.11866278946399689,
0.3441171944141388,
0.25205644965171814,
0.18371707201004028,
-0.04298105463385582,
0.22727148234844208,
-0.008242933079600334,
0.26368248462677,
-0.1308699995279312,
0.07071851938962936,
-0.46617287397384644,
-0.18288086354732513,
-0.15315702557563782,
-0.09350189566612244,
0.2526990473270416,
-0.09043068438768387,
0.124248206615448,
0.13284307718276978,
0.04617266356945038,
0.06477036327123642,
-0.26739805936813354,
-0.08373906463384628,
0.034047696739435196,
-0.21955518424510956,
0.05004483088850975,
-0.37794631719589233,
-0.002407453488558531,
0.20581525564193726,
0.019643081352114677,
-0.19793099164962769,
-0.004649439826607704,
0.012744404375553131,
0.030875153839588165,
0.4873291552066803,
0.030375437811017036,
-0.06133611872792244,
0.05645556002855301,
0.04511678218841553,
0.08450164645910263,
0.0004873824364040047,
0.06020914390683174,
-0.18260975182056427,
0.0743262842297554,
0.1460697203874588,
-0.23298713564872742,
-0.1831909865140915,
-0.16564923524856567,
0.004158175550401211,
0.024454833939671516,
0.19339384138584137,
0.07766632735729218,
0.0969049260020256,
0.011209838092327118,
0.007015214767307043,
-0.18404121696949005,
0.11463184654712677,
0.12859731912612915,
0.1331162005662918,
-0.18164649605751038,
0.15904270112514496,
-0.22326843440532684,
0.22486141324043274,
-0.2752326726913452,
-0.0946047231554985,
0.034102220088243484,
0.10398117452859879,
-0.23046062886714935,
0.029837891459465027,
0.16292285919189453,
-0.1034197211265564,
0.10292033851146698,
-0.13996820151805878,
0.024790223687887192,
-0.1290399730205536,
-0.03506869822740555,
-0.04154370352625847,
-0.21543291211128235,
-0.0720602497458458,
0.28049400448799133,
0.14884884655475616,
-0.06728677451610565,
0.055699143558740616,
-0.3268183767795563,
-0.07192754000425339,
0.026167284697294235,
-0.24734070897102356,
-0.3561125099658966,
0.14855772256851196,
0.02249736338853836,
-0.3109206259250641,
0.0677369236946106,
-0.10157521069049835,
0.17197120189666748,
-0.0746055319905281,
-0.49560004472732544,
-0.25219351053237915,
0.19663786888122559,
-0.13048864901065826,
0.05223768949508667,
-0.3410851061344147,
-0.14004890620708466,
-0.16517958045005798,
0.2213016152381897,
-0.03044269047677517,
0.1942286342382431,
-0.15833890438079834,
-0.128874272108078,
-0.13741613924503326,
0.02520471066236496,
-0.17135341465473175,
0.16308178007602692,
-0.10377396643161774,
-0.025813737884163857,
-0.2926594614982605,
-0.30367934703826904,
0.356031209230423,
0.10257391631603241,
-0.17181500792503357,
0.01172654889523983,
0.1121499314904213,
0.021119417622685432,
0.08255960792303085,
0.07605632394552231,
-0.1937880963087082,
0.0027228600811213255,
-0.27485620975494385,
-0.2063189595937729,
-0.12185508757829666,
-0.07128555327653885,
-0.007980850525200367,
0.1330709606409073,
0.2581983804702759,
0.19171494245529175,
-0.046850305050611496,
-0.24953177571296692,
0.18259987235069275,
-0.07745647430419922,
-0.10817902535200119,
0.1838885098695755,
-0.29637962579727173,
0.354678213596344,
-0.1986323744058609,
0.10158878564834595,
0.2823157012462616,
0.07328370958566666,
-0.2849770486354828,
-0.07253700494766235,
-0.08687856048345566,
0.14292655885219574,
-0.08952278643846512,
0.23842251300811768,
-0.0987260490655899,
-0.24070818722248077,
0.07318194210529327,
0.16038356721401215,
-0.16467781364917755,
-0.033204689621925354,
0.09054665267467499,
0.1128959059715271,
0.05864759907126427,
0.15253031253814697,
0.07145187258720398,
-0.2131422460079193,
-0.3254730999469757,
0.07631552964448929,
-0.16680392622947693,
-0.15129657089710236,
-0.014156471006572247,
0.22935031354427338,
-0.1593550592660904,
0.08424294739961624,
-0.2937289774417877,
-0.001980364788323641,
0.14406727254390717,
-0.18927910923957825,
0.3576001524925232,
0.017597155645489693,
0.1182941272854805,
0.25185126066207886,
-0.08266565948724747,
-0.0802176371216774,
0.10206003487110138,
0.026646073907613754,
-0.20202142000198364,
-0.013341476209461689,
-0.13419204950332642,
0.08209430426359177,
-0.17354990541934967,
-0.06465525925159454,
0.3470325469970703,
0.3689321279525757,
-0.26664793491363525,
-0.08934761583805084,
0.41203686594963074,
0.1401606947183609,
0.44382157921791077,
0.20401795208454132,
-0.1454049050807953,
-0.3242030441761017,
0.20111064612865448,
-0.3667239248752594,
0.10590386390686035,
-0.22703592479228973,
-0.09270521253347397,
0.09828245639801025,
0.0690835565328598,
0.1253303736448288,
-0.07500109076499939,
-0.10295280814170837,
-0.030471816658973694,
0.17002500593662262,
-0.06975618004798889,
-0.21662431955337524,
0.403400182723999,
-0.2173500508069992,
-0.16773343086242676,
0.20106852054595947,
0.22299528121948242,
-0.22563809156417847,
-0.2895616590976715,
0.11412160843610764,
-0.1751311868429184,
-0.09228694438934326,
-0.04299670830368996,
-0.2014448493719101,
-0.16544006764888763,
0.19874995946884155,
0.282912015914917,
0.16052982211112976,
0.009551186114549637,
0.14668536186218262,
0.09452361613512039,
0.08404497802257538,
-0.018491705879569054,
0.013221560046076775,
-0.020350821316242218,
0.054910559207201004,
-0.15275074541568756,
-0.002203861018642783,
-0.12084774672985077,
0.07794564217329025,
-0.011248791590332985,
0.08680348098278046,
-0.128875270485878,
0.26036694645881653,
0.248685821890831,
0.10912986844778061,
0.2335314005613327,
-0.46187159419059753,
-0.027760811150074005,
0.11613541096448898,
0.13721179962158203,
0.3815343379974365,
-0.07239426672458649,
0.13676364719867706,
-0.011766382493078709,
0.09882472455501556,
-0.10387277603149414,
0.02452017553150654,
0.0008240776369348168,
0.025932621210813522,
0.251015305519104,
0.10908441990613937,
0.19510509073734283,
0.3011399805545807,
0.10233160108327866,
0.20012211799621582,
-0.006841439753770828,
-0.05220736563205719,
0.11513541638851166,
-0.08788561820983887,
-0.024684516713023186,
0.04980345442891121,
-0.1945294290781021,
-0.19361235201358795,
-0.02231152355670929,
0.08908162266016006,
0.08710659295320511,
-0.17679116129875183,
-0.0377945639193058,
0.34373024106025696,
0.09974560141563416,
-0.1712765246629715,
-0.11902739852666855,
-0.2690444886684418,
0.1340467780828476,
0.17872919142246246,
0.24327352643013,
-0.02514629438519478,
0.2475840002298355,
0.2012551724910736,
-0.028576187789440155,
0.00680873217061162,
-0.04103345796465874,
0.08356540650129318,
-0.28246358036994934,
-0.030029447749257088,
0.053382355719804764,
-0.38634487986564636,
0.2275109440088272,
0.045148517936468124,
-0.130323126912117,
0.053097449243068695,
-0.00459914468228817,
0.145427405834198,
0.15659832954406738,
0.488646537065506,
0.11283154040575027,
0.13903377950191498,
0.30819979310035706,
-0.07696574926376343,
0.10903923213481903,
0.07552824914455414,
0.11029113829135895,
-0.09828434139490128,
0.0006680552614852786,
0.11512936651706696,
0.1105106920003891,
-0.2458222210407257,
-0.1166306883096695,
0.18523548543453217,
0.488310307264328,
-0.06221453845500946,
-0.108843594789505,
0.15139922499656677,
-0.10704173147678375,
-0.07498791813850403,
0.04227154329419136,
-0.043368689715862274,
-0.04649995639920235,
0.0912151038646698,
-0.16982440650463104,
-0.175613135099411,
-0.22956855595111847,
0.12303224205970764,
-0.01546960324048996,
0.018652021884918213,
0.3408525288105011,
0.2367127686738968,
0.09405278414487839,
-0.19345185160636902,
-0.13451431691646576,
-0.13385888934135437,
-0.23758456110954285,
-0.059851665049791336,
0.11935613304376602,
-0.13231408596038818,
0.4001389443874359,
-0.13652674853801727,
0.2872733175754547,
0.13669638335704803,
-0.020871609449386597,
0.45216289162635803,
-0.2425905019044876,
-0.09520801156759262,
0.03827664628624916,
0.025911467149853706,
-0.10928793996572495,
-0.04001007229089737,
-0.22521381080150604,
0.008709329180419445,
-0.16713444888591766,
0.025380348786711693,
0.12418749928474426,
0.09766104817390442,
-0.09515423327684402,
-0.08935058116912842,
0.027910081669688225,
0.19439174234867096,
0.11364777386188507,
0.15229812264442444,
0.10380927473306656,
-0.26307258009910583,
0.09629471600055695,
-0.304701566696167,
0.3125385046005249,
0.21403145790100098,
0.013559045270085335,
-0.22172163426876068,
0.006858424283564091,
-0.321377694606781,
0.2795253396034241,
-0.062076352536678314,
0.23502881824970245,
-0.18892733752727509,
0.1101931557059288,
0.07176996022462845,
0.14633619785308838,
-0.0697222650051117,
0.06771455705165863,
0.08546872437000275,
-0.21701617538928986,
0.024049799889326096,
0.2191803902387619,
-0.09848190099000931,
-0.08758912980556488,
-0.25075066089630127,
0.20652137696743011,
-0.03889302909374237,
0.1540975421667099,
-0.22419995069503784,
0.0863904133439064,
-0.03128276392817497,
-0.46830055117607117,
0.22040635347366333,
0.13726069033145905,
0.27378958463668823,
0.05190957337617874,
-0.2565839886665344,
-0.054467011243104935,
-0.3418399393558502,
0.21403297781944275,
0.009197810664772987,
0.2561546862125397,
-0.08395581692457199,
0.06788048893213272,
-0.4293345510959625,
-0.10216177999973297,
-0.016657812520861626,
-0.09545230120420456,
-0.1439080536365509,
-0.294874906539917,
0.14850427210330963,
-0.1480618268251419,
0.23740112781524658,
-0.1650415062904358,
0.0230630524456501,
-0.044149383902549744,
-0.41416436433792114,
0.07852482050657272,
0.07644860446453094,
-0.07472594082355499,
-0.3251156210899353,
0.024966223165392876,
-0.08701948076486588,
-0.03666381537914276,
-0.4888145327568054,
-0.08625215291976929,
0.058095380663871765,
-0.17976805567741394,
-0.13605856895446777,
0.3173379898071289,
-0.09298890084028244,
0.10014080256223679,
-0.10695692896842957,
0.14879110455513,
0.11328988522291183,
0.13961726427078247,
-0.08632209151983261,
0.06611748784780502,
-0.2620428800582886,
-0.06588084250688553,
-0.04258759319782257,
-0.0037810676731169224,
-0.1386568695306778,
-0.06420376896858215,
-0.019247815012931824,
0.2850959897041321,
0.20001208782196045,
0.18806670606136322,
0.3231992721557617,
-0.09987270832061768,
-0.30371329188346863,
-0.11607515066862106,
0.22792749106884003,
0.4148602783679962,
-0.2710893452167511,
-0.20900382101535797,
0.09667966514825821,
-0.19849881529808044,
-0.08458840847015381,
0.10294841229915619,
-0.013938159681856632,
-0.026762811467051506,
-0.18655705451965332,
-0.008951611816883087,
0.17217890918254852,
0.3180880546569824,
-0.07664775848388672,
0.37405794858932495,
0.0014807406114414334,
0.21053871512413025,
-0.04551541805267334,
-0.044362153857946396,
-0.03288555145263672,
0.09669887274503708,
-0.014991684816777706,
0.11837072670459747,
0.08809276670217514,
0.25003552436828613,
0.2154788374900818,
-0.13222812116146088,
-0.0052818413823843,
-0.18314100801944733,
0.1441320776939392,
0.24731576442718506,
-0.14746586978435516,
0.007406525779515505,
0.11639789491891861,
-0.07289071381092072,
0.11282029002904892,
-0.301353394985199,
0.18442818522453308,
-0.28023645281791687,
0.1652441769838333,
-0.016324596479535103,
-0.266414076089859,
-0.2263132631778717,
-0.19419194757938385,
0.19304494559764862,
-0.06079566106200218,
0.027012869715690613,
-0.013791927136480808,
0.1962798833847046,
-0.2108902782201767,
-0.07697045803070068,
-0.06048014387488365,
0.14913254976272583,
-0.3313993811607361,
0.07620172202587128,
0.016700608655810356,
0.24782094359397888,
-0.09640795737504959,
-0.02474893443286419,
0.190405011177063,
0.21017764508724213,
-0.09302070736885071,
0.009987331926822662,
-0.23361119627952576,
-0.38914304971694946,
-0.24726630747318268,
-0.05803743749856949,
0.2893804609775543,
0.10509520769119263,
-0.25271138548851013,
-0.26281124353408813,
0.26529550552368164,
0.08236139267683029,
0.5111407041549683,
0.2410053163766861,
-0.2563764750957489,
-0.14177465438842773,
-0.06291607767343521,
0.1716006100177765,
0.30157795548439026,
0.17826618254184723,
-0.07202687114477158,
0.33234497904777527,
-0.13025858998298645,
-0.04383907467126846,
-0.10808802396059036,
0.34712570905685425,
0.23304122686386108,
-0.04658184573054314,
-0.03563997521996498,
0.3610684871673584,
-0.3345335125923157,
-0.27738964557647705,
0.08728265762329102,
0.04756739363074303,
0.18966740369796753,
0.03487908095121384,
0.4220505952835083,
-0.23348167538642883,
-0.09712588042020798,
0.07435191422700882,
0.18856100738048553,
-0.011672800406813622,
-0.11125616729259491,
-0.10740198194980621,
-0.010906927287578583,
-0.11655973643064499,
0.1985028237104416,
-0.2185065895318985,
0.13579639792442322,
-0.09013670682907104,
0.0006860870053060353,
-0.1170700341463089,
-0.16745875775814056,
-0.10008644312620163,
0.05447680875658989,
0.03892848640680313,
0.022615287452936172,
-0.07184212654829025,
0.19774195551872253,
-0.25693434476852417,
0.184478297829628,
0.06450474262237549,
0.0705031082034111,
-0.2044912576675415,
-0.030066318809986115,
-0.45064690709114075,
-0.09392503648996353,
-0.11927393823862076,
0.004350431729108095,
-0.08308737725019455,
-0.005139179993420839,
-0.08689412474632263,
-0.2236340194940567,
0.006011885590851307,
0.19141142070293427,
0.1410117894411087,
-0.12553860247135162,
-0.0720047652721405,
0.2355046421289444,
0.014604277908802032,
-0.178322434425354,
-0.13042595982551575,
0.019839761778712273,
0.26457154750823975,
0.360003262758255,
0.17363160848617554,
-0.02321477234363556,
0.0893193930387497,
0.03119388408958912,
-0.07860002666711807,
-0.12198583781719208,
0.014817308634519577,
-0.0741572231054306,
-0.4636611044406891,
-0.03242509812116623,
0.10798167437314987,
0.2722109258174896,
0.007682271301746368,
0.3038986623287201,
0.19689325988292694,
0.017138969153165817
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. ionylcarnitine.Maternal B12 deficiency identified through elevated propionylcarnitine on the newborn screen can also present with elevated urinary methylmalonic acid and total plasma homocysteine in infant. In maternal vitamin B12 deficiency, infant vitamin B12 levels can be in the normal range .Urine organic acid assay in individuals with carbonic anhydrase VA deficiency can reveal elevated 3-hydroxypropionic acid, propionylglycine, and methylcitric acid as well as 3-methylcrotonylglycine, 3-hydroxybutyric, alpha-ketoglutaric, and 3-hydroxyisovaleric acids. Plasma acylcarnitine profile in individuals with carbonic anhydrase VA deficiency is usually normal.Methylmalonic semialdehyde dehydrogenase deficiency may result in accumulation of 3-hydroxyisobutyric, 3-hydroxypropionic, 3-aminoisobutyric, and methylmalonic acids .Bacterial overgrowth (including Propionibacterium or Lactobacterium) or short gut syndrome Mitochondrial disorder may enter the differential diagnosis when individuals present | [
0.0676116943359375,
-0.09320138394832611,
-0.14959189295768738,
-0.2349681556224823,
0.19954410195350647,
0.17097246646881104,
-0.059434738010168076,
-0.21029773354530334,
0.11507095396518707,
0.10193724930286407,
0.23188640177249908,
0.05480194836854935,
0.08601000159978867,
0.031127899885177612,
-0.1761094480752945,
0.14862613379955292,
0.011306985281407833,
-0.21771672368049622,
-0.17038750648498535,
-0.2637677788734436,
0.10762134939432144,
-0.21028731763362885,
-0.062099698930978775,
0.234288290143013,
0.11902672052383423,
-0.16656620800495148,
0.13135011494159698,
-0.13009782135486603,
0.19720853865146637,
0.002074894728139043,
-0.20497243106365204,
-0.20362161099910736,
0.24190714955329895,
-0.02899225987493992,
0.12124688923358917,
-0.17452992498874664,
-0.014421324245631695,
-0.3537103831768036,
0.0748545229434967,
-0.1861659735441208,
-0.019356457516551018,
-0.17158634960651398,
0.12817268073558807,
-0.07664951682090759,
0.11355394124984741,
-0.16795706748962402,
0.02874942682683468,
-0.06199661269783974,
0.012030634097754955,
0.0576493926346302,
0.04792681708931923,
-0.13670560717582703,
-0.3730250298976898,
-0.14006946980953217,
0.25493916869163513,
-0.07032255083322525,
-0.37658610939979553,
-0.09823357313871384,
-0.22689098119735718,
0.3320978879928589,
0.23032279312610626,
-0.03776396065950394,
-0.051613789051771164,
-0.26978057622909546,
0.000827785290312022,
-0.034584663808345795,
-0.0314754843711853,
0.43196243047714233,
0.294404000043869,
0.13127295672893524,
0.0753072202205658,
-0.027689391747117043,
0.0966101586818695,
0.11066567897796631,
-0.29618608951568604,
-0.10877637565135956,
0.009794635698199272,
-0.09654244780540466,
0.15016210079193115,
-0.07589130848646164,
-0.0361124724149704,
0.15895551443099976,
0.011127064004540443,
-0.07067319750785828,
-0.03207852691411972,
0.029342805966734886,
-0.007124148774892092,
0.11464788764715195,
-0.10495813190937042,
0.09445713460445404,
0.22692419588565826,
0.15776057541370392,
0.20122821629047394,
0.07016485929489136,
0.05834628641605377,
-0.1715727150440216,
0.36134326457977295,
-0.07950319349765778,
-0.07608743011951447,
0.21070338785648346,
0.13684752583503723,
0.06380124390125275,
-0.19337700307369232,
-0.1552712470293045,
-0.3308120369911194,
0.09556926786899567,
-0.2440970242023468,
0.09075984358787537,
-0.014635574072599411,
-0.21691986918449402,
0.2592678368091583,
-0.14297178387641907,
0.05010984092950821,
0.10795364528894424,
-0.2884301543235779,
-0.057274773716926575,
0.06778259575366974,
0.14698293805122375,
0.10220834612846375,
0.029788663610816002,
-0.030575452372431755,
0.1539917290210724,
0.16370327770709991,
0.3273056447505951,
0.02573842741549015,
-0.07558196038007736,
0.033575013279914856,
0.059902314096689224,
0.465005099773407,
-0.05899372696876526,
0.046420421451330185,
0.18052150309085846,
-0.13818985223770142,
0.08678620308637619,
0.25389930605888367,
0.06103752925992012,
-0.3846825957298279,
-0.3290799558162689,
-0.027574438601732254,
0.3195561170578003,
0.17935054004192352,
0.015806622803211212,
0.14734379947185516,
0.16786213219165802,
0.2951759099960327,
-0.06329959630966187,
0.277101993560791,
-0.09046964347362518,
0.24055169522762299,
-0.007042617537081242,
-0.00906590186059475,
-0.24808862805366516,
-0.10240534693002701,
0.022086000069975853,
-0.11965296417474747,
0.11986817419528961,
0.04862707853317261,
0.24624405801296234,
-0.024472147226333618,
-0.026843534782528877,
0.060796502977609634,
-0.04229236766695976,
0.0009893691167235374,
-0.15794801712036133,
-0.17423802614212036,
-0.020137889310717583,
-0.3596622347831726,
0.07571738213300705,
0.10435628145933151,
-0.00486402353271842,
-0.3075175881385803,
-0.10657956451177597,
-0.07414519786834717,
0.07006878405809402,
0.3865170478820801,
-0.1348658949136734,
0.08893652260303497,
-0.1129986047744751,
0.10748350620269775,
0.0921420231461525,
0.18663372099399567,
0.15153758227825165,
-0.1414385586977005,
0.04692782461643219,
-0.07614471763372421,
-0.23929129540920258,
-0.050035491585731506,
-0.07581977546215057,
0.08970435708761215,
0.06876610964536667,
0.11563720554113388,
0.045357175171375275,
0.05847359076142311,
-0.1507241278886795,
0.15473031997680664,
-0.21901415288448334,
0.024887708947062492,
-0.18121853470802307,
0.21398714184761047,
-0.01951240748167038,
0.19907249510288239,
-0.23913884162902832,
0.18106484413146973,
-0.31475207209587097,
-0.19542890787124634,
-0.16351161897182465,
0.09331829845905304,
-0.19248618185520172,
0.2163543403148651,
0.22287558019161224,
-0.15011531114578247,
0.10544784367084503,
-0.20168311893939972,
0.09032141417264938,
-0.2317134290933609,
0.042986299842596054,
-0.12146105617284775,
-0.0676499679684639,
-0.14304324984550476,
0.27456632256507874,
0.2147645652294159,
0.2497149109840393,
0.167740136384964,
-0.16539286077022552,
-0.009172812104225159,
0.16695956885814667,
-0.09448566287755966,
-0.18957994878292084,
0.2064370959997177,
-0.07914804667234421,
-0.14781327545642853,
-0.11374377459287643,
-0.07169810682535172,
0.18818998336791992,
0.06243005022406578,
-0.37387415766716003,
-0.313604474067688,
0.08598624169826508,
-0.17536380887031555,
0.17907795310020447,
-0.44655120372772217,
-0.07081205397844315,
-0.1549205482006073,
0.18970602750778198,
0.031679071485996246,
0.07380770146846771,
-0.1567142903804779,
0.029734406620264053,
-0.11835309118032455,
-0.05417146533727646,
-0.061631932854652405,
0.01803433522582054,
-0.056555911898612976,
-0.10473781079053879,
-0.277828186750412,
-0.1537332534790039,
0.1716621369123459,
0.13024364411830902,
-0.0044746678322553635,
-0.03224022686481476,
0.05087325721979141,
0.05751258507370949,
-0.06814804673194885,
0.05636002868413925,
-0.0970117598772049,
-0.16282610595226288,
-0.12622588872909546,
-0.01425502635538578,
-0.1424308717250824,
-0.10173806548118591,
-0.0940086767077446,
0.11384068429470062,
0.3454360067844391,
0.1538999378681183,
0.006251668091863394,
-0.1761283129453659,
0.009177072905004025,
0.055661410093307495,
-0.2023261934518814,
0.1333608627319336,
-0.2508358657360077,
0.348165899515152,
-0.21634097397327423,
0.1387520730495453,
0.14902345836162567,
0.13156315684318542,
-0.0744296982884407,
0.061919260770082474,
-0.16643524169921875,
0.17544715106487274,
0.11695222556591034,
0.17657655477523804,
-0.12873193621635437,
-0.3285628855228424,
0.0855574756860733,
-0.013403128832578659,
-0.029802294448018074,
0.105351522564888,
0.04590381309390068,
0.11091914027929306,
0.01677292212843895,
0.08590753376483917,
-0.03681696951389313,
-0.1847495585680008,
-0.34224244952201843,
0.05869821831583977,
-0.013973241671919823,
-0.0727507621049881,
0.1567411571741104,
0.1332327425479889,
-0.023291459307074547,
0.021399524062871933,
-0.2837006747722626,
0.1621159315109253,
-0.051978543400764465,
-0.12018924951553345,
0.34967178106307983,
0.04217377305030823,
0.016080928966403008,
0.25117743015289307,
0.05947244539856911,
0.09836044162511826,
0.08610953390598297,
0.0757891833782196,
-0.24176709353923798,
0.07673973590135574,
0.08700195699930191,
0.13756786286830902,
-0.050404880195856094,
-0.10007718205451965,
0.3506120443344116,
-0.04450630396604538,
-0.21623407304286957,
0.06240607425570488,
0.40274807810783386,
0.12538540363311768,
0.4024946689605713,
0.24393849074840546,
-0.06337721645832062,
-0.3111032247543335,
0.1292313188314438,
-0.35503676533699036,
0.0916772335767746,
-0.1488819271326065,
-0.18354375660419464,
-0.015617744997143745,
-0.03205157816410065,
0.1950438916683197,
-0.0664139911532402,
-0.21096369624137878,
-0.1449539065361023,
0.060899149626493454,
0.03703268617391586,
-0.36079978942871094,
0.2581154704093933,
-0.02232959307730198,
-0.16076603531837463,
0.16231253743171692,
0.22335712611675262,
0.018580585718154907,
-0.2842375338077545,
0.05519743263721466,
-0.15935908257961273,
-0.19319795072078705,
-0.09499219059944153,
-0.2337900996208191,
-0.0579601414501667,
0.19586467742919922,
0.22199983894824982,
0.21363003551959991,
-0.07483411580324173,
0.11593884229660034,
0.167078897356987,
0.03207295387983322,
-0.11232810467481613,
0.06468971818685532,
0.05103170871734619,
-0.017554456368088722,
-0.1790880262851715,
-0.13079087436199188,
-0.12174221873283386,
0.014204801060259342,
0.006724386941641569,
0.23306536674499512,
-0.012153083458542824,
0.0990084633231163,
-0.05175800248980522,
0.09108984470367432,
0.29727989435195923,
-0.32436060905456543,
-0.1681414395570755,
-0.025774547830224037,
0.08189155161380768,
0.334283709526062,
-0.0592924989759922,
0.12744441628456116,
-0.038736045360565186,
-0.038724686950445175,
-0.03787408024072647,
0.005710401106625795,
0.1047687903046608,
0.11403249204158783,
0.29203855991363525,
0.11411242932081223,
0.017088137567043304,
0.324876993894577,
0.05626225098967552,
0.07152020186185837,
-0.34871089458465576,
-0.09856472909450531,
-0.05681454762816429,
-0.08631552755832672,
-0.1932600438594818,
0.04995754733681679,
-0.2355404794216156,
-0.2114987075328827,
-0.012365080416202545,
0.16639558970928192,
0.17230673134326935,
-0.004264935851097107,
-0.004449136555194855,
0.15501366555690765,
0.06671436876058578,
-0.048331379890441895,
-0.1525038331747055,
-0.06148698925971985,
0.04128111153841019,
0.3364659249782562,
0.2110891491174698,
0.11413741111755371,
0.11711957305669785,
0.20399753749370575,
0.1929910033941269,
-0.10815355181694031,
-0.08589441329240799,
0.1140693947672844,
-0.17402024567127228,
0.1869385987520218,
0.026921996846795082,
-0.15692129731178284,
0.16191290318965912,
0.057499852031469345,
-0.12973029911518097,
0.20217742025852203,
-0.16067713499069214,
0.27936580777168274,
0.2009010761976242,
0.4007332921028137,
0.0717434212565422,
0.11110992729663849,
0.04748087376356125,
0.03611736744642258,
0.1373954564332962,
-0.03326428309082985,
0.082076296210289,
0.07925156503915787,
0.0753585547208786,
-0.05219757556915283,
-0.06228485703468323,
-0.13441875576972961,
-0.12028014659881592,
0.13635915517807007,
0.3592170774936676,
-0.09504203498363495,
-0.18433712422847748,
0.1883077621459961,
-0.17723827064037323,
-0.08074931055307388,
0.022828225046396255,
-0.10027097165584564,
0.1034582257270813,
-0.08295749872922897,
-0.2533562481403351,
-0.09410455822944641,
-0.024901404976844788,
0.02324962429702282,
0.04864652082324028,
-0.0638246238231659,
0.22889167070388794,
0.24405533075332642,
-0.009695509448647499,
-0.12246449291706085,
0.0872412621974945,
-0.11431394517421722,
-0.03400896117091179,
0.045348938554525375,
0.07917965203523636,
-0.15796101093292236,
0.3123249411582947,
0.11778521537780762,
0.19178354740142822,
0.098576620221138,
0.07002881169319153,
0.3078005313873291,
-0.1615987867116928,
-0.05229673907160759,
0.05022295191884041,
0.008233435451984406,
-0.04981260001659393,
0.12233231216669083,
0.08950145542621613,
-0.09927663952112198,
-0.10366591811180115,
0.2108953446149826,
0.05985057353973389,
0.1497991532087326,
-0.07069496065378189,
-0.15126585960388184,
0.09780259430408478,
0.3083753287792206,
0.1538698375225067,
0.1235852912068367,
0.0028753518126904964,
-0.09632936865091324,
0.1898752748966217,
-0.28864020109176636,
0.16852279007434845,
0.2319810390472412,
0.13190710544586182,
-0.10951300710439682,
0.1296834796667099,
-0.3278229534626007,
0.175473153591156,
-0.15776373445987701,
0.2527548372745514,
-0.07898405939340591,
-0.010371116921305656,
0.14702387154102325,
-0.01274606678634882,
-0.010349374264478683,
-0.055144794285297394,
-0.01563205011188984,
-0.3039897084236145,
0.11336824297904968,
0.2138163447380066,
-0.046655405312776566,
0.04765436425805092,
-0.19527624547481537,
0.15383316576480865,
-0.20450812578201294,
0.15111777186393738,
-0.24801227450370789,
-0.0356367826461792,
-0.08050428330898285,
-0.3992297649383545,
0.2369077056646347,
0.1946258693933487,
0.1771017462015152,
0.2563232183456421,
-0.034051209688186646,
-0.1435861438512802,
-0.2955099940299988,
-0.01243763417005539,
0.0891011506319046,
0.1813136339187622,
-0.16935719549655914,
0.1018146201968193,
-0.36689186096191406,
-0.15558627247810364,
-0.023103738203644753,
-0.08946149796247482,
0.09357986599206924,
-0.16732105612754822,
0.20119576156139374,
-0.1564164161682129,
0.222311332821846,
-0.14182431995868683,
0.06672429293394089,
-0.03647347912192345,
-0.4256463050842285,
0.05021781101822853,
-0.14572583138942719,
-0.04492761939764023,
-0.1286001354455948,
-0.0008153098751790822,
0.13376353681087494,
-0.11373228579759598,
-0.23249070346355438,
-0.2739410102367401,
0.20261694490909576,
-0.06488008797168732,
-0.13444742560386658,
0.2277819812297821,
0.051391180604696274,
0.006724725943058729,
-0.05059856176376343,
0.09506100416183472,
0.1417771428823471,
0.2267208993434906,
0.003258894896134734,
0.050816141068935394,
-0.32961446046829224,
-0.052584003657102585,
-0.14483673870563507,
0.06450124084949493,
-0.23452191054821014,
0.08506443351507187,
-0.022384395822882652,
0.21754856407642365,
0.1888314187526703,
0.1452363282442093,
0.1482476145029068,
-0.14693427085876465,
-0.26428598165512085,
-0.2196332812309265,
0.2329491227865219,
0.30122801661491394,
-0.2771596908569336,
-0.058155834674835205,
0.011144695803523064,
-0.052082359790802,
-0.05140374228358269,
0.15963777899742126,
0.08791908621788025,
-0.022403309121727943,
-0.03343730419874191,
-0.01667015627026558,
0.14178359508514404,
0.16939358413219452,
-0.05888580530881882,
0.16129642724990845,
0.006822899449616671,
0.2718256413936615,
-0.17705081403255463,
-0.028552209958434105,
0.056189052760601044,
-0.04389697685837746,
-0.07098954170942307,
-0.043447982519865036,
-0.013882395811378956,
0.27084168791770935,
0.07195957750082016,
-0.13985678553581238,
0.15362237393856049,
-0.22476021945476532,
0.018492497503757477,
0.025936516001820564,
-0.002054321812465787,
-0.020507723093032837,
-0.016057202592492104,
-0.10114022344350815,
-0.0010449825786054134,
-0.12295227497816086,
0.22438094019889832,
-0.34777188301086426,
0.20463424921035767,
-0.02606263756752014,
-0.06929599493741989,
-0.12604211270809174,
0.07415203750133514,
0.07500588893890381,
0.028007134795188904,
-0.05372418090701103,
0.03726748004555702,
0.2912417948246002,
-0.03274007886648178,
-0.027057332918047905,
-0.25668057799339294,
0.0010443611536175013,
-0.20487965643405914,
0.03983626142144203,
0.011119849048554897,
0.03226562961935997,
0.04744736850261688,
-0.0011368166888132691,
0.07116468250751495,
0.30549079179763794,
0.05433431267738342,
0.03869086503982544,
-0.2959980070590973,
-0.1787983477115631,
-0.18514607846736908,
-0.15447647869586945,
0.22963540256023407,
0.25918784737586975,
-0.0020025516860187054,
-0.15839150547981262,
0.07398322969675064,
-0.06188368797302246,
0.4454742968082428,
0.2404235154390335,
-0.2730167508125305,
-0.26345017552375793,
-0.057311587035655975,
0.08852226287126541,
0.21209555864334106,
0.1309180110692978,
0.05200684443116188,
0.2470608651638031,
-0.2697044909000397,
0.039087530225515366,
-0.23366867005825043,
0.1107059195637703,
0.22519581019878387,
-0.11432868242263794,
-0.06308338791131973,
0.4637216329574585,
-0.24799928069114685,
-0.23753000795841217,
-0.03066391684114933,
-0.0918307974934578,
0.2538180649280548,
0.1429021805524826,
0.21631698310375214,
-0.35664641857147217,
-0.010520639829337597,
0.17560914158821106,
-0.009679222479462624,
0.006233842112123966,
0.06699471175670624,
-0.2374732941389084,
-0.04563608765602112,
-0.009796414524316788,
0.24269260466098785,
-0.10451382398605347,
0.16956640779972076,
-0.03338862955570221,
-0.02771262638270855,
-0.13299071788787842,
-0.05695895478129387,
0.008326750248670578,
0.16338513791561127,
0.025041984394192696,
-0.03075174242258072,
0.08920583128929138,
0.23881082236766815,
0.11627396941184998,
0.03541569039225578,
0.015750354155898094,
0.11013101041316986,
-0.13192759454250336,
0.04929216578602791,
-0.4220399856567383,
-0.16188032925128937,
-0.038694851100444794,
0.031220125034451485,
-0.15969160199165344,
-0.16505491733551025,
-0.2097194641828537,
-0.19648237526416779,
-0.00950575154274702,
0.17658498883247375,
0.0035703876055777073,
-0.082726389169693,
0.1265517771244049,
0.32099464535713196,
-0.010278145782649517,
-0.13664954900741577,
-0.23600871860980988,
-0.29641878604888916,
0.10189076513051987,
0.2631046772003174,
0.055103808641433716,
-0.09530409425497055,
0.04043979197740555,
-0.023251283913850784,
-0.32676011323928833,
-0.12465560436248779,
0.10556881129741669,
0.04115414619445801,
-0.28335732221603394,
-0.051738571375608444,
-0.02276103012263775,
0.14740188419818878,
-0.08432649075984955,
0.30509650707244873,
-0.00029811629792675376,
-0.07783088088035583
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. -hydroxybutyric, alpha-ketoglutaric, and 3-hydroxyisovaleric acids. Plasma acylcarnitine profile in individuals with carbonic anhydrase VA deficiency is usually normal.Methylmalonic semialdehyde dehydrogenase deficiency may result in accumulation of 3-hydroxyisobutyric, 3-hydroxypropionic, 3-aminoisobutyric, and methylmalonic acids .Bacterial overgrowth (including Propionibacterium or Lactobacterium) or short gut syndrome Mitochondrial disorder may enter the differential diagnosis when individuals present with hyperammonemia, metabolic acidosis, ketonuria, and hypoglycemia .Hyperglycinemia can be seen in a wide range of clinical conditions including nonketotic hyperglycinemia, valproate treatment, ketotic hyperglycinemia, and transient glycine encephalopathy. See Glycine Encephalopathy.Hyperammonemia in neonatal PA can prompt clinicians to consider other disorders affecting ammonia metabolism including urea cycle disorders, organic acidemias, pyruvate carboxylase deficiency, carbonic anhydrase VA deficiency, and porto-systemic | [
-0.017803598195314407,
-0.007508866023272276,
-0.19618989527225494,
-0.3209332227706909,
0.1427917182445526,
0.04226749390363693,
0.040956977754831314,
-0.2483825534582138,
0.05089149996638298,
-0.019530385732650757,
0.2987462282180786,
-0.09570879489183426,
-0.004560657311230898,
0.09437244385480881,
-0.12416476011276245,
0.1933523565530777,
0.08680781722068787,
-0.12855468690395355,
-0.2203366756439209,
-0.14218662679195404,
0.1247360035777092,
-0.1798696666955948,
0.02592429518699646,
0.2321051061153412,
0.1673242300748825,
-0.0897652804851532,
0.25854063034057617,
-0.3288026750087738,
0.29784926772117615,
0.0005317566683515906,
-0.09668053686618805,
-0.03997575491666794,
0.14744114875793457,
-0.2828923761844635,
0.11627990007400513,
-0.23463937640190125,
-0.11210621893405914,
-0.3274073004722595,
0.10231553763151169,
-0.32176610827445984,
0.023113615810871124,
-0.17104710638523102,
0.1194579228758812,
-0.007745597045868635,
0.23092211782932281,
-0.10795262455940247,
-0.05311598256230354,
-0.00849210936576128,
0.021665988489985466,
0.172683447599411,
0.1673639416694641,
-0.0046018389984965324,
-0.36251378059387207,
-0.14219099283218384,
0.23385226726531982,
-0.2804645299911499,
-0.21648770570755005,
-0.04721052944660187,
-0.17135578393936157,
0.17316116392612457,
0.08540737628936768,
-0.20307287573814392,
-0.05980679392814636,
-0.26067984104156494,
0.009824150241911411,
-0.10282887518405914,
-0.07220428436994553,
0.2476881593465805,
0.21215344965457916,
0.03944264352321625,
0.15208280086517334,
-0.11380594968795776,
-0.08833442628383636,
0.038622066378593445,
-0.1932835578918457,
-0.05174889788031578,
0.018900716677308083,
-0.0587267205119133,
-0.018820887431502342,
-0.028488967567682266,
-0.14275209605693817,
0.1288328766822815,
0.008409408852458,
-0.14615020155906677,
0.02786215953528881,
0.18809619545936584,
0.1366163194179535,
-0.011592814698815346,
-0.10786569118499756,
0.10549759864807129,
0.17842997610569,
0.004855951759964228,
-0.012828437611460686,
-0.0374324768781662,
0.05571874603629112,
-0.10081267356872559,
0.19997750222682953,
-0.014752967283129692,
-0.24486415088176727,
0.1867491751909256,
0.04013550281524658,
-0.010332595556974411,
-0.26833534240722656,
-0.09870756417512894,
-0.19522106647491455,
0.1544833928346634,
-0.24819503724575043,
-0.03795742616057396,
-0.12303661555051804,
-0.03691588342189789,
0.07392382621765137,
-0.3498626947402954,
0.11672054976224899,
0.13863003253936768,
-0.4075474441051483,
-0.1413172036409378,
-0.06955449283123016,
0.09940031170845032,
0.12093719840049744,
0.11667954176664352,
-0.061589643359184265,
0.19133242964744568,
-0.005331921856850386,
0.1888858675956726,
0.011343914084136486,
0.09660966694355011,
0.07525493949651718,
0.01207757368683815,
0.36418622732162476,
-0.19106659293174744,
0.06849365681409836,
-0.036993108689785004,
0.07116391509771347,
0.017854655161499977,
0.27985644340515137,
0.03577636927366257,
-0.3230140209197998,
-0.25383907556533813,
0.09721264243125916,
0.12151019275188446,
0.22081387042999268,
0.05087478831410408,
0.1312178522348404,
0.12350766360759735,
0.19337141513824463,
-0.12262657284736633,
0.26373526453971863,
-0.033364299684762955,
0.1136205792427063,
-0.016186878085136414,
-0.18266457319259644,
-0.2664240896701813,
-0.05290435999631882,
0.004575806669890881,
-0.0621626116335392,
0.17863529920578003,
0.029286209493875504,
0.17232373356819153,
-0.08119501173496246,
-0.041574422270059586,
0.07758468389511108,
0.019207844510674477,
0.05937952920794487,
-0.07208610326051712,
-0.14223873615264893,
0.07566235214471817,
-0.39573296904563904,
0.08618928492069244,
-0.16099561750888824,
-0.04081807658076286,
-0.1858733892440796,
-0.06795646250247955,
0.023274069651961327,
0.07696956396102905,
0.14771978557109833,
-0.06727736443281174,
0.015928154811263084,
0.009570945054292679,
0.10737866908311844,
0.21877489984035492,
0.30605348944664,
0.14754995703697205,
-0.34046584367752075,
0.06465446203947067,
-0.1665666699409485,
-0.17585332691669464,
0.04773956164717674,
0.0825660303235054,
0.07992224395275116,
0.07972722500562668,
0.22518101334571838,
-0.02597222290933132,
0.12330790609121323,
-0.0713348388671875,
-0.0024876731913536787,
-0.22656171023845673,
0.06454454362392426,
-0.2386247217655182,
0.09684048593044281,
-0.03364130109548569,
0.10164386034011841,
-0.1870783269405365,
0.19910360872745514,
-0.194637268781662,
-0.21660134196281433,
-0.10507933050394058,
0.09695318341255188,
-0.16529271006584167,
0.22620809078216553,
0.07404419034719467,
-0.23459893465042114,
0.15890659391880035,
-0.18751198053359985,
0.1117820218205452,
-0.308109313249588,
0.047544121742248535,
0.08584731072187424,
-0.061156466603279114,
-0.07203944772481918,
0.11251331865787506,
0.14023232460021973,
0.1523217111825943,
0.27414077520370483,
-0.22928835451602936,
-0.042559560388326645,
0.13734880089759827,
-0.15853913128376007,
-0.0789237767457962,
0.2439955174922943,
-0.16250352561473846,
-0.10589798539876938,
-0.12921898066997528,
-0.06723135709762573,
0.23896540701389313,
-0.1104450672864914,
-0.2034199833869934,
-0.2754993140697479,
0.19308917224407196,
-0.22279472649097443,
0.23152762651443481,
-0.5833294987678528,
-0.09961453825235367,
0.02682734839618206,
0.18599621951580048,
-0.18404389917850494,
-0.0029134955257177353,
-0.07866596430540085,
0.022493692114949226,
0.019283413887023926,
0.05275902897119522,
-0.1259516477584839,
0.060357268899679184,
-0.015870900824666023,
-0.12068399786949158,
-0.3583652675151825,
-0.08008583635091782,
0.0147138936445117,
0.044478558003902435,
0.10985073447227478,
0.017483480274677277,
-0.11832360923290253,
0.16987252235412598,
0.0628877803683281,
-0.15390938520431519,
-0.0008740948978811502,
-0.12554146349430084,
-0.09121455997228622,
0.2394038289785385,
-0.25864025950431824,
-0.17016391456127167,
-0.05210372060537338,
0.2025003731250763,
0.17212432622909546,
0.17616528272628784,
-0.08039181679487228,
-0.2095884531736374,
0.09176336228847504,
0.02793615683913231,
-0.01998179778456688,
0.018018148839473724,
-0.21532636880874634,
0.3131817579269409,
-0.07625853270292282,
0.22040285170078278,
0.2063213735818863,
0.20586997270584106,
-0.046512458473443985,
0.1185416728258133,
-0.14904047548770905,
0.10513553768396378,
0.12315063178539276,
0.21140043437480927,
-0.16980910301208496,
-0.2745952904224396,
0.05664319172501564,
0.04013318940997124,
-0.12399289011955261,
0.12683157622814178,
0.06280554831027985,
0.1459248811006546,
0.0657462403178215,
0.11798381060361862,
0.17511355876922607,
-0.07758330553770065,
-0.4094073176383972,
-0.012062040157616138,
-0.06725671887397766,
-0.10430701822042465,
0.2170969694852829,
0.14874811470508575,
-0.02469852939248085,
-0.148554265499115,
-0.15865668654441833,
0.12333998084068298,
-0.06825099140405655,
0.02271733619272709,
0.15716981887817383,
0.07045801728963852,
0.1259036511182785,
0.12282147258520126,
-0.07003084570169449,
0.09180864691734314,
0.023896152153611183,
0.045283038169145584,
-0.12891431152820587,
-0.02510910853743553,
0.12235455214977264,
-0.034941136837005615,
-0.05195682868361473,
0.13366903364658356,
0.23316094279289246,
-0.08426368236541748,
-0.1239505186676979,
0.00543567119166255,
0.34341540932655334,
0.0008763087680563331,
0.26705050468444824,
-0.012840737588703632,
-0.06093696132302284,
-0.05799536779522896,
0.12790437042713165,
-0.36578041315078735,
0.02827921323478222,
-0.22712725400924683,
-0.1831732988357544,
-0.001664729556068778,
-0.06087531894445419,
0.23323257267475128,
0.0257574412971735,
-0.09725706279277802,
-0.18418890237808228,
0.04586612805724144,
0.009683234617114067,
-0.2962740361690521,
0.14432404935359955,
-0.050653405487537384,
-0.07101279497146606,
0.1289745271205902,
0.03291953727602959,
0.16545434296131134,
-0.29377177357673645,
0.16138184070587158,
-0.12280460447072983,
-0.163366436958313,
-0.07413721084594727,
-0.2187112271785736,
0.04928245022892952,
0.05626923590898514,
0.2509811520576477,
0.022438988089561462,
0.07393499463796616,
0.10751999169588089,
0.21036362648010254,
0.052980270236730576,
-0.10842658579349518,
0.18371319770812988,
0.040002286434173584,
-0.008684749715030193,
-0.2319973260164261,
-0.15185020864009857,
-0.04120304808020592,
-0.009459597058594227,
0.10480017960071564,
0.03311888501048088,
0.08683192729949951,
-0.04743468761444092,
-0.16091112792491913,
0.1788395196199417,
0.30611318349838257,
-0.47662484645843506,
-0.08265705406665802,
0.04127967730164528,
0.005668024532496929,
0.2578469514846802,
0.0031966364476829767,
0.1667570173740387,
-0.06337077170610428,
-0.03605376183986664,
-0.19614367187023163,
0.08345586806535721,
0.07738426327705383,
0.06052067503333092,
0.2552011013031006,
0.13003669679164886,
-0.02738642692565918,
0.24544738233089447,
0.04155214503407478,
0.06466030329465866,
-0.28520628809928894,
0.04263266548514366,
0.05494537577033043,
-0.1588580459356308,
-0.14666630327701569,
-0.04029073193669319,
-0.18459713459014893,
-0.2086656540632248,
0.012863121926784515,
0.20768415927886963,
0.19756972789764404,
0.07727671414613724,
0.10996317118406296,
0.06297560781240463,
0.10962752252817154,
-0.05643390864133835,
-0.23814399540424347,
0.07630366086959839,
0.08429735153913498,
0.084841787815094,
0.16376566886901855,
0.20114055275917053,
0.10695017874240875,
0.10823255777359009,
0.10812859237194061,
-0.08303924649953842,
0.03878660500049591,
0.1106400191783905,
-0.3163350820541382,
0.26539361476898193,
-0.0351722426712513,
-0.04767966642975807,
0.20305322110652924,
0.04541398957371712,
-0.11744695156812668,
0.15039771795272827,
-0.17033900320529938,
0.3034209609031677,
0.26887720823287964,
0.30682694911956787,
0.053802650421857834,
0.16720861196517944,
0.1141277626156807,
0.028205646201968193,
-0.028051914647221565,
0.04393396154046059,
0.0582369826734066,
0.23771445453166962,
0.0765819326043129,
-0.022170910611748695,
0.03017481416463852,
-0.007189459167420864,
-0.17064130306243896,
0.16848431527614594,
0.30482107400894165,
-0.1709534078836441,
-0.22279003262519836,
0.12137758731842041,
-0.27997204661369324,
0.01792692393064499,
0.02515321969985962,
-0.07107987254858017,
0.1480431705713272,
-0.057806193828582764,
-0.13456086814403534,
-0.07913386076688766,
-0.05693608149886131,
0.007543649058789015,
-0.06644241511821747,
0.011048988439142704,
-0.0870361402630806,
0.3022749722003937,
-0.04240893945097923,
-0.1476450264453888,
0.13248716294765472,
-0.033955954015254974,
-0.09134810417890549,
0.07411840558052063,
-0.07148939371109009,
-0.1327907145023346,
0.37324637174606323,
-0.0157929640263319,
0.08764922618865967,
0.12725786864757538,
0.02681039646267891,
0.28688374161720276,
-0.10288126766681671,
-0.009401833638548851,
0.011032192967832088,
-0.10921940952539444,
-0.012343179434537888,
0.06352508068084717,
0.056998658925294876,
-0.026923498138785362,
-0.19069255888462067,
0.11506427079439163,
-0.02018888108432293,
0.07012788206338882,
-0.11502572149038315,
-0.16640330851078033,
0.0197442676872015,
0.26793256402015686,
0.23627758026123047,
0.06211325526237488,
-0.036621447652578354,
-0.1032826378941536,
0.1446661353111267,
-0.3205454349517822,
0.05923018977046013,
0.2178298830986023,
0.11982131749391556,
-0.12382170557975769,
0.1801593005657196,
-0.15896306931972504,
0.17077088356018066,
-0.03626866638660431,
0.1496627926826477,
-0.15358971059322357,
-0.045825716108083725,
0.15433429181575775,
-0.021353889256715775,
-0.06283152848482132,
0.16051462292671204,
-0.14131593704223633,
-0.19738028943538666,
0.2653510272502899,
0.190402552485466,
-0.0614297054708004,
0.09150136262178421,
-0.19077835977077484,
0.021709632128477097,
-0.20825666189193726,
0.1349641978740692,
-0.24502380192279816,
-0.08993827551603317,
-0.05764195695519447,
-0.3439542353153229,
0.33292388916015625,
0.06684103608131409,
0.11862565577030182,
0.26048868894577026,
0.01662195287644863,
-0.0428028367459774,
-0.23647545278072357,
0.06876857578754425,
0.11880140006542206,
0.02766777016222477,
-0.14743614196777344,
0.1126023530960083,
-0.21681983768939972,
-0.24278481304645538,
0.04077138006687164,
-0.13113190233707428,
-0.019154097884893417,
-0.2286968231201172,
0.047171156853437424,
-0.09568373113870621,
0.19841399788856506,
-0.000551931734662503,
0.002972618443891406,
-0.07864505797624588,
-0.3324255645275116,
0.0721057653427124,
-0.13466909527778625,
0.1683560013771057,
-0.009667241014540195,
-0.1273806095123291,
0.15112167596817017,
-0.20790836215019226,
-0.3259659707546234,
-0.28820672631263733,
0.1506398320198059,
0.017548764124512672,
-0.189592182636261,
0.1373617947101593,
0.06171300262212753,
0.06480098515748978,
-0.062473759055137634,
0.08577632904052734,
0.13678640127182007,
0.34305915236473083,
0.12398713827133179,
-0.008205882273614407,
-0.30435100197792053,
0.13700507581233978,
-0.09956859797239304,
0.11488427966833115,
-0.30988606810569763,
0.22324077785015106,
-0.1880301833152771,
0.2208160161972046,
0.18356868624687195,
0.42301008105278015,
0.11762508004903793,
-0.03205650672316551,
-0.18267454206943512,
-0.19520443677902222,
0.07757610082626343,
0.17620861530303955,
-0.3457798659801483,
0.017613401636481285,
0.07194586843252182,
0.07280212640762329,
0.09865822643041611,
0.22954323887825012,
0.020337246358394623,
0.07780660688877106,
-0.06695568561553955,
0.21152760088443756,
-0.020927615463733673,
0.0914868414402008,
0.008969797752797604,
0.3287796378135681,
-0.04113208130002022,
0.2847897410392761,
-0.15580038726329803,
-0.10057709366083145,
0.11951747536659241,
-0.07537858188152313,
-0.12480097264051437,
-0.031512945890426636,
0.045291293412446976,
0.15630604326725006,
0.05840345099568367,
-0.02707795426249504,
0.17921918630599976,
-0.1766950488090515,
-0.025096360594034195,
0.1503574699163437,
0.10444753617048264,
-0.13359671831130981,
0.1611856371164322,
-0.23938266932964325,
-0.015943795442581177,
0.01744704693555832,
0.12287032604217529,
-0.40621259808540344,
0.2027849704027176,
-0.22386376559734344,
-0.09006233513355255,
0.014175386168062687,
-0.05200016498565674,
0.04655275493860245,
-0.06679476052522659,
-0.1157233864068985,
0.14340491592884064,
0.3502691984176636,
0.007277138531208038,
-0.05684980750083923,
-0.24143797159194946,
0.06073363497853279,
-0.07906166464090347,
0.04218851774930954,
0.15585674345493317,
0.032910823822021484,
-0.02677798457443714,
-0.06164155155420303,
0.10267051309347153,
0.3111957311630249,
0.03250531479716301,
0.032549500465393066,
-0.3190975785255432,
-0.2179182469844818,
-0.030231734737753868,
-0.0206089336425066,
0.15675471723079681,
0.2365543693304062,
0.04645736142992973,
-0.014005379751324654,
0.1212826669216156,
-0.07415774464607239,
0.49282991886138916,
0.12419604510068893,
-0.26662641763687134,
-0.2573662996292114,
-0.10811205953359604,
0.24001382291316986,
0.06012992188334465,
0.049990829080343246,
-0.05042974278330803,
0.2847774624824524,
-0.3288588523864746,
0.10231485217809677,
-0.16709968447685242,
0.002840386237949133,
0.1894920915365219,
0.004195121582597494,
0.033076703548431396,
0.447802871465683,
-0.16148674488067627,
-0.16044224798679352,
-0.15317675471305847,
-0.04358964040875435,
0.3158051371574402,
0.07362554967403412,
0.2075333446264267,
-0.1283530443906784,
-0.19994230568408966,
0.24951587617397308,
-0.1518169492483139,
0.054660454392433167,
-0.03739158436655998,
-0.19485318660736084,
-0.13730110228061676,
0.018929684534668922,
0.14572077989578247,
0.03053865022957325,
0.19426438212394714,
-0.10664059966802597,
-0.03682013973593712,
-0.0651843324303627,
-0.14105376601219177,
0.09233872592449188,
0.045136891305446625,
0.01521280873566866,
-0.10429038107395172,
-0.03521338477730751,
0.08705917745828629,
0.0778898075222969,
0.019693363457918167,
-0.034820687025785446,
-0.026803145185112953,
-0.1442599594593048,
-0.030638165771961212,
-0.39775705337524414,
0.013095997273921967,
-0.11296207457780838,
-0.09870761632919312,
-0.037681031972169876,
-0.08104861527681351,
-0.23768682777881622,
-0.08500631898641586,
0.044186417013406754,
0.25422999262809753,
-0.004003842361271381,
-0.08283881098031998,
-0.018658975139260292,
0.3498999774456024,
-0.029570067301392555,
0.004215773195028305,
-0.05215086415410042,
-0.09469695389270782,
0.07847248017787933,
0.26720190048217773,
-0.09026492387056351,
0.08051939308643341,
0.0023619208950549364,
-0.03657675161957741,
-0.20606206357479095,
-0.12373435497283936,
0.14287608861923218,
-0.02414354868233204,
-0.22597235441207886,
0.05493979901075363,
0.0514933243393898,
0.06208278238773346,
-0.12501047551631927,
0.2752099931240082,
0.015913141891360283,
0.06841882318258286
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. the differential diagnosis when individuals present with hyperammonemia, metabolic acidosis, ketonuria, and hypoglycemia .Hyperglycinemia can be seen in a wide range of clinical conditions including nonketotic hyperglycinemia, valproate treatment, ketotic hyperglycinemia, and transient glycine encephalopathy. See Glycine Encephalopathy.Hyperammonemia in neonatal PA can prompt clinicians to consider other disorders affecting ammonia metabolism including urea cycle disorders, organic acidemias, pyruvate carboxylase deficiency, carbonic anhydrase VA deficiency, and porto-systemic shunts. Usually, the glutamine levels in hyperammonemic patients with PA are normal or low .Increased anion-gap metabolic acidosis. Possible causes are numerous and may include the following:Those conditions included in the commonly used mnemonic MUDPILES: methanol, uremia (chronic renal failure), diabetic ketoacidosis, propylene glycol, infection, iron, isoniazid, lactic acidosis, ethylene glycol, salicylatesOrganic acidemiasPoisoning and child abuse. In | [
0.07181312143802643,
0.08562475442886353,
-0.21001215279102325,
-0.2428743541240692,
0.0335942879319191,
0.10978593677282333,
0.0033630384132266045,
-0.2256622165441513,
-0.04721884801983833,
-0.09882295876741409,
0.3406929075717926,
-0.1630987972021103,
0.004176911432296038,
0.011911993846297264,
-0.11539600044488907,
0.012910773977637291,
0.037375565618276596,
-0.024182254448533058,
-0.14680318534374237,
-0.05034341290593147,
0.1824924647808075,
-0.082887202501297,
-0.10617971420288086,
0.3270047903060913,
0.15213219821453094,
-0.19345536828041077,
0.21371406316757202,
-0.36049684882164,
0.2333134561777115,
0.026575187221169472,
-0.2630614936351776,
0.08125442266464233,
0.09069002419710159,
-0.16734381020069122,
-0.05305500701069832,
-0.17464758455753326,
-0.12652522325515747,
-0.34489285945892334,
0.1377505362033844,
-0.3187178075313568,
0.1773892194032669,
-0.12708719074726105,
0.23579970002174377,
-0.007322253659367561,
0.2366211712360382,
-0.14574584364891052,
-0.1210893839597702,
-0.04823402315378189,
-0.1874481588602066,
0.2973298728466034,
0.25067901611328125,
-0.1356283575296402,
-0.3553731441497803,
-0.0038235625252127647,
0.11699178069829941,
-0.2445211410522461,
-0.07173355668783188,
0.030592890456318855,
-0.11609343439340591,
0.1982208490371704,
0.009106503799557686,
-0.2954082190990448,
-0.20005036890506744,
-0.41963788866996765,
0.04906375706195831,
-0.18013691902160645,
-0.1608733832836151,
0.2074730396270752,
0.1313456892967224,
-0.20667250454425812,
0.02035130187869072,
-0.027143608778715134,
-0.11960001289844513,
0.07798495888710022,
-0.21214832365512848,
-0.03778853639960289,
0.11559955030679703,
-0.1799747347831726,
0.049526769667863846,
-0.1367737501859665,
-0.1909235566854477,
0.01689089834690094,
0.016785908490419388,
-0.04686010256409645,
0.03331425040960312,
0.036792952567338943,
0.2706010043621063,
-0.0029263028409332037,
-0.16314531862735748,
0.155423104763031,
0.06725899875164032,
0.09169961512088776,
-0.00023346382658928633,
0.008667794056236744,
0.23067332804203033,
-0.20499733090400696,
0.24175505340099335,
-0.041421711444854736,
-0.11591118574142456,
0.18916290998458862,
0.059634730219841,
0.10573357343673706,
-0.18809275329113007,
0.06818070262670517,
-0.1533355414867401,
0.1493629366159439,
-0.00864134356379509,
-0.052229829132556915,
-0.11812810599803925,
-0.01909036561846733,
0.1100262925028801,
-0.204830139875412,
0.1629258245229721,
0.14810402691364288,
-0.4557105600833893,
-0.3063165247440338,
-0.04415950924158096,
0.2372940480709076,
0.09403952211141586,
-0.04491954669356346,
-0.05395045503973961,
0.07270720601081848,
0.038282610476017,
0.10304943472146988,
-0.13870084285736084,
0.045870762318372726,
0.0575890876352787,
-0.04013315960764885,
0.2287931889295578,
-0.2706032395362854,
0.1986146718263626,
-0.06930974870920181,
0.1841604858636856,
-0.12418600171804428,
0.24627099931240082,
-0.026445286348462105,
-0.17845918238162994,
-0.2477564513683319,
0.0023034741170704365,
0.10893815755844116,
0.3690212070941925,
0.12297923862934113,
0.205476313829422,
0.1257719099521637,
0.1567045897245407,
0.03783310577273369,
0.1388569325208664,
0.03320116922259331,
0.07989870756864548,
0.0037372643128037453,
-0.21804513037204742,
-0.30241724848747253,
0.06497593969106674,
0.0805138498544693,
-0.17369309067726135,
0.18973739445209503,
-0.005170435644686222,
0.2947292625904083,
-0.1279735267162323,
0.12697066366672516,
-0.1543436497449875,
0.04542224854230881,
-0.06418222934007645,
0.06294150650501251,
-0.1689252108335495,
0.07184431701898575,
-0.4035828411579132,
0.12229432910680771,
-0.13704189658164978,
-0.13312096893787384,
-0.13810130953788757,
-0.07788500934839249,
0.04258662462234497,
-0.005290297791361809,
0.1529037058353424,
-0.1617613285779953,
-0.03962774574756622,
0.026167212054133415,
0.011483556590974331,
0.23967930674552917,
0.33621931076049805,
0.11433190852403641,
-0.3837374448776245,
0.1227501630783081,
-0.16373279690742493,
-0.06797820329666138,
0.06207460165023804,
0.07855492830276489,
0.06989910453557968,
0.10731836408376694,
0.21034392714500427,
0.027790598571300507,
-0.042996641248464584,
0.0743216723203659,
0.12764288485050201,
-0.21259580552577972,
0.17412693798542023,
-0.1357518881559372,
0.0658503994345665,
-0.099455825984478,
-0.06929145753383636,
-0.2522883415222168,
0.20525960624217987,
-0.08012233674526215,
-0.13590668141841888,
-0.12264462560415268,
0.2579600512981415,
-0.13101665675640106,
0.130489781498909,
0.05597666651010513,
-0.26390907168388367,
0.2291584461927414,
-0.25707805156707764,
-0.0566740557551384,
-0.27166420221328735,
-0.03596975654363632,
0.02689696103334427,
-0.17629610002040863,
0.025524059310555458,
0.1351480334997177,
-0.025375494733452797,
0.037575654685497284,
0.07775037735700607,
-0.1732369214296341,
-0.009826644323766232,
0.004415396135300398,
-0.2223542034626007,
-0.19464220106601715,
0.14630931615829468,
-0.12319160997867584,
-0.2204253375530243,
0.13888372480869293,
-0.01659919135272503,
0.22492799162864685,
-0.167377769947052,
-0.2941143810749054,
-0.21021057665348053,
0.24526986479759216,
-0.18831591308116913,
-0.04659699648618698,
-0.4722296893596649,
0.04874731972813606,
0.0505409799516201,
-0.0348820686340332,
-0.03695432469248772,
0.005464597605168819,
0.05078480765223503,
-0.051118072122335434,
0.06967799365520477,
0.022682541981339455,
-0.02417636848986149,
0.1745307445526123,
0.05796379595994949,
0.04943715035915375,
-0.3321916162967682,
-0.043862029910087585,
0.08431100100278854,
-0.07792358100414276,
0.03812384977936745,
-0.08189131319522858,
-0.19562043249607086,
0.09450135380029678,
-0.032414842396974564,
-0.019663004204630852,
-0.008637282066047192,
-0.12895531952381134,
-0.08756205439567566,
0.0946723073720932,
-0.16544048488140106,
-0.22414718568325043,
-0.03889705613255501,
0.360456258058548,
0.12583988904953003,
0.13464975357055664,
-0.21995088458061218,
-0.18401490151882172,
0.2855604887008667,
-0.032156240195035934,
0.024143440648913383,
0.09407594799995422,
-0.0799044817686081,
0.2610359787940979,
0.028871143236756325,
0.01464705727994442,
0.1802162230014801,
0.13261760771274567,
-0.1274346262216568,
0.12797389924526215,
-0.11868571490049362,
0.04459941387176514,
0.17277204990386963,
0.26189684867858887,
-0.06845468282699585,
-0.22093923389911652,
0.215140700340271,
0.06873257458209991,
-0.1682463437318802,
0.11771184951066971,
-0.025327682495117188,
0.22772826254367828,
0.03687682002782822,
0.07611101120710373,
0.037378739565610886,
0.023493507876992226,
-0.3609149158000946,
-0.051716145128011703,
-0.1133255809545517,
-0.23870690166950226,
0.22287783026695251,
0.2790062427520752,
-0.009269324131309986,
-0.15636181831359863,
-0.07960624992847443,
0.07661492377519608,
-0.015226262621581554,
0.013149225153028965,
0.021178197115659714,
0.17962747812271118,
0.05828080698847771,
0.21372480690479279,
0.03628987446427345,
0.09746702760457993,
0.14729371666908264,
0.19784443080425262,
-0.19960834085941315,
-0.0633547306060791,
0.1648970991373062,
0.03599308803677559,
-0.02972317300736904,
0.17638665437698364,
0.12047097831964493,
-0.015804806724190712,
-0.11351574212312698,
-0.0790599137544632,
0.35090622305870056,
-0.051612094044685364,
0.35578423738479614,
-0.12038791179656982,
-0.15438567101955414,
-0.04343350976705551,
0.19580824673175812,
-0.5022898316383362,
0.027538705617189407,
-0.12120383232831955,
-0.31871265172958374,
-0.0508316345512867,
-0.019101759418845177,
0.2918746769428253,
0.17725834250450134,
-0.06305995583534241,
-0.14899267256259918,
0.1732688844203949,
-0.05073503777384758,
-0.14946702122688293,
0.07186739891767502,
0.011697741225361824,
0.02178521640598774,
0.14483165740966797,
0.030624691396951675,
0.016605008393526077,
-0.22182971239089966,
0.07174187153577805,
-0.02271355129778385,
-0.19113928079605103,
0.0025281962007284164,
-0.14485560357570648,
0.0038123498670756817,
0.0481802299618721,
0.2342429906129837,
-0.1340552270412445,
0.008239202201366425,
0.10264024138450623,
0.1754302829504013,
0.023725681006908417,
-0.008041652850806713,
0.0389464795589447,
0.03207860514521599,
-0.050988320261240005,
-0.3535782992839813,
-0.1741551160812378,
0.014357092790305614,
0.1302739530801773,
0.004673379007726908,
-0.01857251673936844,
0.11371937394142151,
-0.046787068247795105,
-0.21009869873523712,
0.16388845443725586,
0.28714606165885925,
-0.47289639711380005,
0.027182284742593765,
0.1272769719362259,
-0.004619451239705086,
0.2476978600025177,
0.09079352766275406,
0.16817913949489594,
-0.059369057416915894,
-0.025008518248796463,
-0.13232745230197906,
0.11546281725168228,
0.12208633124828339,
0.06366606801748276,
0.14670486748218536,
0.20134899020195007,
0.1195773258805275,
0.2787817418575287,
-0.12358295172452927,
0.10668683052062988,
-0.17272764444351196,
0.10540639609098434,
0.1411246806383133,
-0.19325537979602814,
-0.04947255551815033,
-0.05359607934951782,
-0.052547186613082886,
-0.09495064616203308,
-0.16582922637462616,
0.1973663717508316,
0.20959782600402832,
0.0876096785068512,
0.1146010085940361,
-0.0006350866751745343,
-0.030400188639760017,
0.005203266628086567,
-0.12104376405477524,
0.12898331880569458,
0.1306006759405136,
0.02239365130662918,
-0.010452386923134327,
0.18620561063289642,
0.20343652367591858,
0.14692093431949615,
0.11630024760961533,
-0.036479778587818146,
-0.1455182284116745,
0.07902789115905762,
-0.24083296954631805,
0.06988967955112457,
-0.11390420794487,
-0.07256089895963669,
0.16490478813648224,
-0.010901798494160175,
-0.1601390391588211,
0.14221718907356262,
-0.13033804297447205,
0.060597408562898636,
0.2034536451101303,
0.21929748356342316,
-0.011998401023447514,
0.20408128201961517,
0.21694517135620117,
-0.07768341153860092,
-0.1486443132162094,
-0.035312432795763016,
0.15644313395023346,
0.10389545559883118,
0.09286100417375565,
0.03913396969437599,
0.025023408234119415,
-0.04442208632826805,
-0.2971928119659424,
0.12732616066932678,
0.3308751583099365,
-0.12762080132961273,
-0.22675679624080658,
0.12600946426391602,
-0.28242817521095276,
-0.012753926217556,
-0.071497343480587,
0.04844951629638672,
0.10469336062669754,
0.1810787320137024,
0.02689565159380436,
0.05657307431101799,
0.014636460691690445,
0.13504348695278168,
-0.1414760798215866,
0.010575064457952976,
-0.06793344765901566,
0.22795963287353516,
0.04701356589794159,
-0.15555870532989502,
0.12798090279102325,
-0.10743174701929092,
-0.21151433885097504,
0.10977894812822342,
-0.09928983449935913,
0.056855686008930206,
0.4000965356826782,
-0.08115542680025101,
0.12567353248596191,
0.009984231553971767,
0.0777290016412735,
0.39681440591812134,
-0.1722925901412964,
-0.09802208840847015,
-0.03890146687626839,
-0.09030841290950775,
0.024487566202878952,
0.11298561841249466,
-0.1256241351366043,
0.05685603991150856,
-0.0859086886048317,
-0.051052555441856384,
0.03309882432222366,
0.045183416455984116,
0.00712673831731081,
-0.08372267335653305,
-0.09322009980678558,
0.2093529850244522,
0.204763725399971,
-0.010532746091485023,
-0.0851115733385086,
-0.042370688170194626,
0.20008167624473572,
-0.2799414396286011,
0.08158965408802032,
0.21660417318344116,
0.1443462371826172,
-0.19303852319717407,
0.23091308772563934,
-0.044630665332078934,
0.26563018560409546,
-0.09044022113084793,
0.19446001946926117,
-0.29115521907806396,
0.15457434952259064,
0.1780327558517456,
-0.19483356177806854,
-0.02323472499847412,
0.14978747069835663,
-0.20258058607578278,
-0.1867554783821106,
0.19796477258205414,
0.21250751614570618,
-0.018426133319735527,
-0.021325882524251938,
-0.24791984260082245,
0.07897145301103592,
-0.14355182647705078,
0.1032794862985611,
-0.07093219459056854,
0.042711805552244186,
0.020742394030094147,
-0.44132378697395325,
0.4133036732673645,
0.16553667187690735,
0.18438048660755157,
0.2681088447570801,
-0.1680881679058075,
0.022491296753287315,
-0.14832952618598938,
0.05335604026913643,
0.09881100058555603,
0.11268123239278793,
-0.01091984286904335,
-0.04290115460753441,
-0.25783175230026245,
-0.2633577287197113,
0.008938336744904518,
-0.12566256523132324,
-0.05251165106892586,
-0.19795261323451996,
0.06586610525846481,
-0.22039306163787842,
0.08316221088171005,
-0.04427144303917885,
-0.13855478167533875,
-0.14311078190803528,
-0.1304926723241806,
0.0005722013884223998,
-0.16943809390068054,
0.23067210614681244,
-0.05544038116931915,
-0.048727575689554214,
0.11281625926494598,
-0.17364230751991272,
-0.4364704489707947,
-0.2957298159599304,
0.1847916841506958,
-0.00209334515966475,
-0.22822102904319763,
0.08872257173061371,
-0.06507829576730728,
0.16783663630485535,
0.02612907625734806,
0.06016777828335762,
0.04780803620815277,
0.4228898584842682,
0.15414154529571533,
-0.14407849311828613,
-0.312806636095047,
0.02923327311873436,
0.04061809182167053,
0.06652595847845078,
-0.1786334216594696,
0.2438662350177765,
-0.1495782434940338,
0.23137100040912628,
0.18945321440696716,
0.47625595331192017,
0.10258085280656815,
0.06540780514478683,
-0.1535956859588623,
-0.2381657063961029,
-0.013718180358409882,
0.3491753935813904,
-0.33462440967559814,
-0.07839442044496536,
0.0473736897110939,
0.060756027698516846,
0.11277052015066147,
0.30749574303627014,
-0.10227250307798386,
-0.022629082202911377,
-0.033032841980457306,
0.20078842341899872,
-0.07213561236858368,
0.04754437506198883,
-0.006394367665052414,
0.3856232762336731,
0.04339161515235901,
0.20781037211418152,
-0.15071196854114532,
0.0003351921623107046,
0.11177527159452438,
-0.02209201082587242,
-0.1607384979724884,
0.016017591580748558,
-0.003780245315283537,
0.16653470695018768,
0.13957272469997406,
0.021832821890711784,
0.021305827423930168,
-0.07112826406955719,
0.04483260214328766,
0.11910931766033173,
0.051693227142095566,
-0.12240002304315567,
0.276946485042572,
-0.36690083146095276,
0.05885422229766846,
0.04148389399051666,
0.1542757898569107,
-0.4077853560447693,
0.2030869424343109,
-0.1553708016872406,
-0.19479116797447205,
0.05172719806432724,
-0.29002392292022705,
0.16204339265823364,
-0.03251204267144203,
-0.01642419770359993,
0.05946730077266693,
0.2657020390033722,
-0.14340467751026154,
-0.07543135434389114,
-0.23183923959732056,
0.04573240503668785,
-0.06221908703446388,
0.1090642586350441,
0.10874055325984955,
0.11018415540456772,
-0.0907827690243721,
-0.14186133444309235,
0.20952744781970978,
0.16507074236869812,
-0.18185842037200928,
0.046785544604063034,
-0.24021519720554352,
-0.3224988877773285,
0.05626392364501953,
0.024402912706136703,
-0.06621011346578598,
0.04152075573801994,
-0.04609115049242973,
0.007545360829681158,
0.24434581398963928,
-0.04930362477898598,
0.4724390506744385,
-0.046828385442495346,
-0.2766317129135132,
-0.30530911684036255,
-0.009690641425549984,
0.17474620044231415,
0.07842235267162323,
0.15477697551250458,
-0.1595596820116043,
0.22115163505077362,
-0.29926449060440063,
0.1922842413187027,
0.005320533644407988,
0.11726482957601547,
0.06603464484214783,
-0.07581361383199692,
0.0045417663641273975,
0.4499830901622772,
-0.06428440660238266,
-0.2552371323108673,
-0.08615513145923615,
-0.05910704657435417,
0.1275143027305603,
0.05084808170795441,
0.14515726268291473,
0.0029826792888343334,
-0.1282966434955597,
0.20282045006752014,
-0.06839749217033386,
0.03909621015191078,
-0.3317892551422119,
-0.22263656556606293,
-0.14192649722099304,
-0.06914699077606201,
0.22107847034931183,
-0.06416664272546768,
0.28909754753112793,
-0.01655065454542637,
0.01812700368463993,
-0.05453865975141525,
-0.1901983916759491,
0.1587798148393631,
0.012841599993407726,
-0.04879869520664215,
-0.06263212859630585,
-0.058959413319826126,
0.16483967006206512,
-0.07407847046852112,
0.166988343000412,
-0.03709189221262932,
0.025229554623365402,
-0.23742231726646423,
-0.0011218980653211474,
-0.4500095844268799,
0.09152406454086304,
-0.1293514221906662,
-0.04260113090276718,
0.047048237174749374,
-0.14062532782554626,
-0.1651230901479721,
-0.08289046585559845,
-0.07357482612133026,
0.16804935038089752,
0.041175007820129395,
0.03182385861873627,
-0.05553443357348442,
0.19747185707092285,
-0.010568730533123016,
-0.06751445680856705,
-0.09290479868650436,
-0.11733440309762955,
0.12918075919151306,
0.2644747793674469,
0.037880558520555496,
0.14119839668273926,
0.12320221960544586,
-0.1300046294927597,
-0.09922578930854797,
0.05735402554273605,
-0.10682708770036697,
-0.029178667813539505,
-0.2757004499435425,
-0.01968333125114441,
-0.09832228720188141,
0.08145739883184433,
-0.16644488275051117,
0.41848140954971313,
0.11026807874441147,
0.13143889605998993
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , and porto-systemic shunts. Usually, the glutamine levels in hyperammonemic patients with PA are normal or low .Increased anion-gap metabolic acidosis. Possible causes are numerous and may include the following:Those conditions included in the commonly used mnemonic MUDPILES: methanol, uremia (chronic renal failure), diabetic ketoacidosis, propylene glycol, infection, iron, isoniazid, lactic acidosis, ethylene glycol, salicylatesOrganic acidemiasPoisoning and child abuse. In at least one individual with organic acidemia, propionic acid was misidentified as ethylene glycol . In another case, ethylene glycol poisoning presented with hyperglycinemia and glycolic acid in urine .ManagementThe optimal management of patients with propionic acidemia (PA) is best achieved by a team comprising a physician with metabolic expertise, a dietician, and a genetic counselor. Several proposed acute and chronic management guidelines have become available in recent years . Management of symptomatic hyperammonemic | [
0.0028496491722762585,
0.04441281780600548,
-0.041924621909856796,
-0.00790624413639307,
0.11374484747648239,
0.10098857432603836,
-0.16641665995121002,
-0.2642640471458435,
0.0028887747321277857,
-0.07355668395757675,
0.2993161082267761,
-0.06728128343820572,
-0.025587772950530052,
-0.08234192430973053,
-0.12416008114814758,
0.1319762021303177,
0.07993164658546448,
0.04918724671006203,
-0.11220873147249222,
-0.07712014019489288,
0.0926862433552742,
-0.07874707877635956,
-0.2184521108865738,
0.22778569161891937,
0.18536707758903503,
-0.1464642435312271,
0.2700967490673065,
-0.3759912848472595,
0.05272427201271057,
0.12613926827907562,
-0.2627345621585846,
0.19148722290992737,
-0.010113975964486599,
-0.11806927621364594,
-0.06177281215786934,
-0.12499769032001495,
-0.10888636857271194,
-0.3537602126598358,
0.13219647109508514,
-0.3845595717430115,
0.24528750777244568,
-0.1364595741033554,
0.27826327085494995,
-0.015296335332095623,
0.1880115121603012,
-0.15516504645347595,
-0.10912100225687027,
-0.03243663161993027,
-0.15095148980617523,
0.3097595274448395,
0.17833152413368225,
-0.14666083455085754,
-0.29618898034095764,
-0.07559766620397568,
0.07377810031175613,
-0.2059165984392166,
-0.13390125334262848,
0.016516733914613724,
-0.10101837664842606,
0.18024203181266785,
0.09068065881729126,
-0.24253877997398376,
-0.22578276693820953,
-0.3980320990085602,
0.10064636915922165,
-0.025767341256141663,
-0.25643566250801086,
0.15336748957633972,
0.16366362571716309,
-0.313015341758728,
-0.03803310543298721,
-0.04232913628220558,
0.006569191813468933,
0.054765913635492325,
-0.267297625541687,
-0.0724610760807991,
0.1488693505525589,
-0.26472923159599304,
0.06617014110088348,
-0.00436369888484478,
-0.18141745030879974,
0.06688525527715683,
0.11191439628601074,
0.03142967447638512,
-0.05714293569326401,
0.12807691097259521,
0.2758668065071106,
-0.008588818833231926,
-0.12078877538442612,
0.10281189531087875,
0.13316456973552704,
0.11051008850336075,
0.10669667273759842,
0.09549788385629654,
0.4037202298641205,
-0.29543715715408325,
0.16417530179023743,
-0.07926031202077866,
-0.15960422158241272,
0.10461858659982681,
-0.09214276075363159,
0.14259842038154602,
-0.20166829228401184,
0.10504594445228577,
-0.08121848851442337,
0.2830221652984619,
-0.00048300906200893223,
-0.1510584056377411,
-0.1447020024061203,
0.013581227511167526,
0.21654294431209564,
-0.16044831275939941,
0.15407168865203857,
0.061571262776851654,
-0.4042527377605438,
-0.3173326849937439,
-0.04632313549518585,
0.19997867941856384,
0.10354619473218918,
-0.038605473935604095,
-0.0750020444393158,
-0.016294682398438454,
-0.1020265594124794,
0.09684637188911438,
-0.13963596522808075,
0.03004024177789688,
0.0828089490532875,
-0.02095755748450756,
0.2893688678741455,
-0.2537543475627899,
0.2535766363143921,
-0.11175506561994553,
0.17400184273719788,
-0.08023646473884583,
0.17086423933506012,
-0.029602622613310814,
-0.17945432662963867,
-0.41917502880096436,
-0.15374960005283356,
0.13678349554538727,
0.4283870458602905,
0.04292015731334686,
0.12222849577665329,
0.04970179870724678,
0.19481141865253448,
0.09216166287660599,
0.21182407438755035,
-0.053171928972005844,
0.17488457262516022,
0.1223069354891777,
-0.12333479523658752,
-0.14668770134449005,
0.14173641800880432,
0.09633535891771317,
-0.15656918287277222,
0.05726924166083336,
-0.025253010913729668,
0.2884611487388611,
-0.3594679534435272,
0.18307611346244812,
-0.1990799903869629,
0.0501851923763752,
-0.16327345371246338,
0.07117979973554611,
-0.1320393979549408,
0.11888528615236282,
-0.5045967102050781,
0.13678745925426483,
-0.04258483648300171,
-0.1474180966615677,
-0.11073965579271317,
-0.16028808057308197,
0.11495054513216019,
-0.0492585152387619,
0.11092225462198257,
-0.25156664848327637,
0.11781372874975204,
-0.08192702382802963,
-0.09186621010303497,
0.19067950546741486,
0.3435360789299011,
0.2602662742137909,
-0.37650930881500244,
0.12425512820482254,
-0.16681179404258728,
0.025143537670373917,
0.1764952838420868,
0.05229450389742851,
0.04128507524728775,
0.06275339424610138,
0.1584414839744568,
-0.07051350176334381,
0.004230945836752653,
0.05217919871211052,
0.24092398583889008,
-0.34976422786712646,
0.15633462369441986,
-0.11415224522352219,
0.06256162375211716,
-0.005495569668710232,
-0.07246575504541397,
-0.23558881878852844,
0.1565418690443039,
0.03057374618947506,
-0.024225667119026184,
-0.27033913135528564,
0.16682036221027374,
-0.26769062876701355,
0.1376047283411026,
0.11521116644144058,
-0.17016954720020294,
0.20918500423431396,
-0.44755998253822327,
-0.19545376300811768,
-0.35657405853271484,
-0.11679989099502563,
-0.06622245907783508,
-0.2845052182674408,
0.044254500418901443,
0.16861571371555328,
-0.04127635434269905,
0.056642334908246994,
0.19913925230503082,
-0.2130415290594101,
0.17323841154575348,
0.07417672127485275,
-0.2601601481437683,
-0.09972237795591354,
0.21983656287193298,
-0.14859601855278015,
-0.2949201166629791,
0.19495826959609985,
0.057284753769636154,
0.2016315907239914,
-0.24975980818271637,
-0.3411831855773926,
-0.1947157084941864,
0.2597108781337738,
0.009187084622681141,
-0.12021412700414658,
-0.4475121796131134,
0.1699337214231491,
0.06196955591440201,
-0.20902319252490997,
-0.03961049020290375,
0.0848773717880249,
-0.1305731236934662,
-0.09151165932416916,
-0.03132489323616028,
-0.0020694341510534286,
0.07515310496091843,
0.0947117879986763,
0.11532633751630783,
0.05727316811680794,
-0.3131357431411743,
-0.2057332545518875,
0.23120611906051636,
-0.028064467012882233,
0.05782511085271835,
-0.06678096950054169,
-0.0983184203505516,
0.09477589279413223,
-0.14089031517505646,
0.08747313916683197,
-0.04882873222231865,
0.022568203508853912,
-0.17421205341815948,
0.14312250912189484,
-0.18657447397708893,
-0.1814502477645874,
0.11651003360748291,
0.2820951044559479,
0.04200022667646408,
0.024577530100941658,
-0.2654120624065399,
-0.2725989818572998,
0.28438600897789,
0.062181685119867325,
-0.23840689659118652,
0.10796117037534714,
-0.012460061348974705,
0.48923641443252563,
0.12688088417053223,
0.06372356414794922,
0.22794467210769653,
0.1740051805973053,
-0.15875019133090973,
0.11580467224121094,
-0.22231605648994446,
0.13990415632724762,
0.17199914157390594,
0.17401908338069916,
0.010424276813864708,
-0.3596079349517822,
0.19279900193214417,
0.07584524154663086,
-0.20417195558547974,
0.024094946682453156,
-0.09945114701986313,
0.25832346081733704,
0.13619422912597656,
-0.025832056999206543,
0.06903355568647385,
-0.13729766011238098,
-0.305679589509964,
-0.005403067916631699,
-0.16315507888793945,
-0.24816980957984924,
0.27661073207855225,
0.2063896656036377,
-0.004883104003965855,
-0.14404408633708954,
-0.05830790847539902,
0.09857748448848724,
-0.033730193972587585,
0.0006100357859395444,
0.047719672322273254,
0.19801115989685059,
0.07309547811746597,
0.2090809941291809,
-0.03419274091720581,
-0.018285220488905907,
0.2203429788351059,
0.13091322779655457,
-0.20847663283348083,
0.015476294793188572,
0.05083043500781059,
-0.09490649402141571,
0.03937162831425667,
0.13726098835468292,
0.026938986033201218,
-0.12105388939380646,
-0.002566422801464796,
-0.00040437650750391185,
0.3763693869113922,
0.01993795484304428,
0.3649651110172272,
-0.027918290346860886,
-0.23516027629375458,
-0.0013407078804448247,
0.18005302548408508,
-0.39104631543159485,
0.23177671432495117,
-0.04127778485417366,
-0.3707752227783203,
-0.05089021846652031,
-0.11745745688676834,
0.5052495002746582,
0.061164047569036484,
-0.14555148780345917,
-0.20983654260635376,
0.15719886124134064,
0.05967613682150841,
-0.2002902328968048,
0.13945096731185913,
0.07802429050207138,
0.0004455978632904589,
0.1658373922109604,
0.04080362617969513,
0.004098884295672178,
-0.13657206296920776,
0.07423639297485352,
0.07259451597929001,
-0.19001251459121704,
0.042423512786626816,
-0.027993693947792053,
0.062060654163360596,
0.10586901009082794,
0.24272537231445312,
-0.022207103669643402,
-0.018177533522248268,
0.15829679369926453,
0.059094518423080444,
-0.038224488496780396,
0.0777449682354927,
0.07015335559844971,
0.08231470733880997,
-0.17060145735740662,
-0.3069740831851959,
-0.2397179901599884,
-0.050646159797906876,
0.08570607751607895,
-0.0627821832895279,
0.05873432382941246,
0.09148946404457092,
-0.039507340639829636,
-0.06335104256868362,
0.3412350118160248,
0.13737431168556213,
-0.3670198321342468,
0.12277044355869293,
0.11885232478380203,
-0.02738909050822258,
0.142270028591156,
-0.0694313496351242,
0.06185714155435562,
-0.05697249621152878,
-0.25102946162223816,
-0.04498562216758728,
0.2055545300245285,
0.034484315663576126,
-0.004994774237275124,
0.10011563450098038,
0.2472260445356369,
0.19653289020061493,
0.3249364197254181,
-0.14079521596431732,
0.1727321743965149,
-0.045548710972070694,
0.10454386472702026,
-0.005813950672745705,
-0.2703064978122711,
-0.0464070588350296,
-0.01922011934220791,
-0.022220946848392487,
-0.05607809126377106,
-0.1427135169506073,
0.15146994590759277,
0.23936988413333893,
0.1453832983970642,
0.07833968847990036,
0.09225296974182129,
0.0730433240532875,
-0.11549101769924164,
-0.006766047794371843,
0.3057914078235626,
0.23048046231269836,
-0.1745593100786209,
0.029010552912950516,
0.1520593911409378,
0.3589363098144531,
0.1866476684808731,
0.14618094265460968,
-0.15055300295352936,
-0.12927795946598053,
0.10509581863880157,
-0.29297029972076416,
-0.02356995828449726,
-0.09736867994070053,
-0.06443669646978378,
0.1260395348072052,
-0.005756042432039976,
-0.07226389646530151,
0.1456320434808731,
-0.25123751163482666,
0.07549450546503067,
0.16241490840911865,
0.277240127325058,
0.1451442390680313,
0.23303480446338654,
0.16107405722141266,
0.012670268304646015,
-0.06197188049554825,
-0.10026078671216965,
0.14184518158435822,
0.05724296346306801,
-0.06509840488433838,
0.08569912612438202,
0.10464054346084595,
0.02815845236182213,
-0.2333223670721054,
0.1511843204498291,
0.40127599239349365,
-0.07347013056278229,
-0.1719854772090912,
0.1473512202501297,
-0.2143373191356659,
0.06365276873111725,
-0.08197327703237534,
0.03755881264805794,
0.16887563467025757,
0.18691323697566986,
0.16605547070503235,
0.1121726855635643,
-0.019644904881715775,
0.11510081589221954,
-0.15046991407871246,
-0.08882271498441696,
-0.14311623573303223,
0.1362857073545456,
0.0030643045902252197,
-0.23698946833610535,
0.126425638794899,
-0.07307833433151245,
-0.054962653666734695,
0.1567908227443695,
0.0040439581498503685,
0.016319574788212776,
0.46951550245285034,
-0.03310064598917961,
0.1162683367729187,
0.06861063838005066,
0.16769419610500336,
0.49675649404525757,
-0.220972940325737,
-0.1810166984796524,
0.08301503211259842,
-0.09555108845233917,
0.03309493511915207,
0.11553273350000381,
-0.08892755955457687,
-0.010320702567696571,
-0.050333693623542786,
0.06349875777959824,
0.11914660036563873,
0.0877787172794342,
0.04056829959154129,
-0.13024500012397766,
-0.015010420233011246,
0.17333514988422394,
0.1614065170288086,
0.07484979927539825,
-0.055620111525058746,
-0.13810355961322784,
0.1299290806055069,
-0.2007518708705902,
0.16902165114879608,
0.2279113233089447,
0.29212695360183716,
-0.24482044577598572,
0.0684642568230629,
-0.01639508828520775,
0.11782634258270264,
-0.18202821910381317,
0.17377017438411713,
-0.1868627816438675,
0.20238931477069855,
0.07445141673088074,
-0.29612722992897034,
-0.03681592270731926,
0.17048735916614532,
-0.2550067603588104,
-0.25236982107162476,
0.19678553938865662,
0.3148367702960968,
-0.02350335568189621,
-0.012476346455514431,
-0.20252259075641632,
0.027691982686519623,
-0.17240971326828003,
0.05818032845854759,
-0.2569161057472229,
-0.028927402570843697,
0.008364242501556873,
-0.4439978003501892,
0.5218636393547058,
0.26875361800193787,
0.15934115648269653,
0.3544250726699829,
-0.15864747762680054,
0.09523075819015503,
-0.07005294412374496,
0.12928467988967896,
-0.015109897591173649,
0.09844003617763519,
-0.08604114502668381,
-0.2038024514913559,
-0.2389509528875351,
-0.11862148344516754,
-0.07466932386159897,
-0.06900382041931152,
-0.05983837693929672,
-0.08148429542779922,
0.09049089252948761,
-0.3609861433506012,
0.18192940950393677,
-0.030308499932289124,
-0.0792938843369484,
-0.16839148104190826,
-0.09251004457473755,
0.08348745852708817,
-0.06279055774211884,
0.13326439261436462,
-0.21466557681560516,
0.15535198152065277,
0.22236919403076172,
-0.1568501889705658,
-0.46461546421051025,
-0.32259881496429443,
0.13152086734771729,
-0.14288650453090668,
-0.2961646020412445,
0.19599996507167816,
-0.08403927087783813,
0.11326329410076141,
0.017494745552539825,
0.13454358279705048,
0.12410522252321243,
0.43756261467933655,
0.09946276247501373,
-0.048840370029211044,
-0.21932440996170044,
0.08394919335842133,
0.08496545255184174,
0.12461616843938828,
-0.21027053892612457,
0.28342321515083313,
-0.0966346338391304,
0.24938425421714783,
0.07836899161338806,
0.34912538528442383,
0.09285247325897217,
0.10689570009708405,
-0.12271522730588913,
-0.14205212891101837,
0.004216530825942755,
0.2816030979156494,
-0.30489382147789,
-0.2318640947341919,
0.14080537855625153,
0.07043079286813736,
0.0996645838022232,
0.19602537155151367,
-0.13357435166835785,
-0.06480357050895691,
0.009729729034006596,
0.05450727790594101,
-0.12145236134529114,
0.053104352205991745,
0.06239452213048935,
0.40009167790412903,
0.1782386302947998,
0.18707625567913055,
-0.08825330436229706,
0.027837278321385384,
0.14099860191345215,
-0.14956103265285492,
-0.22516943514347076,
0.15441088378429413,
-0.02145942486822605,
0.24240465462207794,
0.20710992813110352,
-0.06010423228144646,
0.13278788328170776,
-0.04722132906317711,
0.059875376522541046,
-0.032312799245119095,
-0.00902207475155592,
-0.06637371331453323,
0.30561721324920654,
-0.4136664569377899,
-0.027463532984256744,
0.09794038534164429,
0.0654020830988884,
-0.40377986431121826,
0.1412564069032669,
-0.19396987557411194,
-0.12359298020601273,
0.08925345540046692,
-0.41168972849845886,
0.14798565208911896,
-0.025407394394278526,
-0.0853184312582016,
0.08629613369703293,
0.28164297342300415,
-0.09035363048315048,
0.10127773880958557,
-0.23619340360164642,
0.0849214643239975,
-0.21302451193332672,
0.11855955421924591,
0.12856628000736237,
0.056573960930109024,
-0.1657554805278778,
-0.20626474916934967,
0.17113642394542694,
0.11603166162967682,
-0.17299677431583405,
-0.018558992072939873,
-0.20881788432598114,
-0.21418331563472748,
0.13725443184375763,
0.09188714623451233,
-0.017415404319763184,
0.19906266033649445,
-0.10374249517917633,
0.004678043536841869,
0.19350753724575043,
-0.12554572522640228,
0.5194140672683716,
-0.03135823830962181,
-0.20499014854431152,
-0.26671937108039856,
0.08785752952098846,
0.09098970144987106,
0.08943413943052292,
0.09071873128414154,
-0.13472522795200348,
0.14043959975242615,
-0.29160019755363464,
0.25467029213905334,
0.004169445019215345,
0.06651666015386581,
-0.05663735792040825,
-0.23150695860385895,
0.09526956081390381,
0.5390518307685852,
0.07218865305185318,
-0.18006464838981628,
-0.1484547108411789,
-0.13653874397277832,
0.20926882326602936,
-0.025851139798760414,
0.0918528214097023,
-0.07862526178359985,
-0.0062241400592029095,
0.11661919206380844,
0.030466804280877113,
0.06196213886141777,
-0.23968519270420074,
-0.22998611629009247,
-0.18909941613674164,
-0.06907179951667786,
0.24595524370670319,
-0.20031899213790894,
0.3165467083454132,
-0.019507909193634987,
0.08898452669382095,
-0.3274032771587372,
-0.1383170485496521,
0.09438104927539825,
0.005985002499073744,
-0.0839623212814331,
-0.012234424240887165,
-0.08816869556903839,
0.1621439903974533,
-0.04159553349018097,
0.27257463335990906,
0.036080509424209595,
0.177079439163208,
-0.22629182040691376,
-0.009421159513294697,
-0.5060771107673645,
0.03470590338110924,
-0.05192781612277031,
0.06967844814062119,
0.04456251487135887,
-0.2630741000175476,
-0.1559199094772339,
-0.004673659335821867,
-0.1306086927652359,
0.15626248717308044,
-0.015837043523788452,
0.037692807614803314,
0.11861183494329453,
0.31385087966918945,
0.04088645428419113,
0.0353732593357563,
-0.1543521285057068,
-0.1818874180316925,
-0.04070228338241577,
0.3003321588039398,
0.06080282852053642,
0.048566676676273346,
0.1379505693912506,
-0.1819763034582138,
-0.04232429340481758,
0.05774196609854698,
-0.05570245161652565,
-0.007854373194277287,
-0.36099952459335327,
0.07009286433458328,
-0.07683354616165161,
0.04063611105084419,
-0.15063337981700897,
0.4364752769470215,
0.0816187933087349,
0.043058257550001144
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. ing and child abuse. In at least one individual with organic acidemia, propionic acid was misidentified as ethylene glycol . In another case, ethylene glycol poisoning presented with hyperglycinemia and glycolic acid in urine .ManagementThe optimal management of patients with propionic acidemia (PA) is best achieved by a team comprising a physician with metabolic expertise, a dietician, and a genetic counselor. Several proposed acute and chronic management guidelines have become available in recent years . Management of symptomatic hyperammonemic patients awaiting confirmatory testing can be particularly challenging and requires pursuit of several diagnostic considerations . Also see Baumgartner et al : Table 6.Evaluations Following Initial DiagnosisTo establish the extent of disease and needs of an individual diagnosed with PA the following evaluations are recommended (see Figure 2) if they have not already been completed:Blood gas with base balance, electrolytes with anion gap, glucose, plasma ammonia, calcium, phosphorus, urine ketonesPlasma amino acids, total | [
-0.08997614681720734,
0.006311099510639906,
-0.05862483009696007,
-0.21303695440292358,
0.03455420956015587,
0.1084052249789238,
-0.01777065545320511,
-0.23167434334754944,
-0.038979340344667435,
-0.08260577917098999,
0.100917287170887,
0.010717874392867088,
-0.0913970023393631,
-0.0676906481385231,
-0.21944767236709595,
0.07380372285842896,
0.13221564888954163,
-0.08112482726573944,
-0.03879963979125023,
0.015978511422872543,
0.2167493999004364,
-0.06655256450176239,
-0.07134024053812027,
0.21032369136810303,
0.2566719055175781,
-0.1247987374663353,
0.27561435103416443,
-0.2716379463672638,
0.21315349638462067,
0.07113706320524216,
-0.1955662965774536,
0.030548961833119392,
0.12621377408504486,
-0.1714865118265152,
-0.18131697177886963,
-0.16401486098766327,
-0.054368190467357635,
-0.33967405557632446,
0.035625506192445755,
-0.3044629395008087,
0.12346962094306946,
-0.23065005242824554,
0.41942769289016724,
-0.008928594179451466,
0.1743413358926773,
-0.1953725963830948,
-0.0189378559589386,
-0.19474616646766663,
-0.16883403062820435,
0.0993906781077385,
0.16077883541584015,
-0.02346210554242134,
-0.331525593996048,
-0.043619751930236816,
0.21014195680618286,
-0.30984020233154297,
-0.22197265923023224,
-0.016843803226947784,
-0.17459768056869507,
-0.046674322336912155,
0.042977578938007355,
-0.21184943616390228,
-0.2947639524936676,
-0.22108061611652374,
0.15629321336746216,
-0.15285851061344147,
-0.0908672958612442,
0.1250109225511551,
0.2016720175743103,
-0.19992342591285706,
0.047403495758771896,
0.011413893662393093,
0.0518849715590477,
0.08195167779922485,
-0.16898716986179352,
0.05002417787909508,
0.026745382696390152,
-0.10220542550086975,
0.12830273807048798,
-0.3366590738296509,
-0.2874879837036133,
-0.058513376861810684,
0.049148790538311005,
-0.03690546751022339,
-0.0561993382871151,
0.0572972446680069,
0.21414965391159058,
0.08069314062595367,
-0.03744162619113922,
0.13149850070476532,
0.12019850313663483,
0.07280795276165009,
0.02507033385336399,
-0.037686239928007126,
0.1987733542919159,
-0.2067384570837021,
0.2266351878643036,
0.025037501007318497,
-0.22804805636405945,
-0.0023926144931465387,
0.05353499948978424,
0.1441376507282257,
-0.15908804535865784,
-0.1017635390162468,
-0.15620966255664825,
0.10688057541847229,
-0.09353143721818924,
-0.12373355031013489,
-0.05244356766343117,
0.014292577281594276,
0.18853342533111572,
-0.14072783291339874,
0.23748795688152313,
0.08286575973033905,
-0.510358452796936,
-0.23094995319843292,
-0.028435347601771355,
0.33383050560951233,
-0.01660984195768833,
0.0775327980518341,
-0.049016211181879044,
-0.00046515429858118296,
0.07824765145778656,
0.029658744111657143,
-0.03292253240942955,
0.04650252312421799,
0.10704172402620316,
-0.16709700226783752,
0.28211721777915955,
-0.25530126690864563,
0.08722314983606339,
0.05131419375538826,
0.11459427326917648,
0.03995313495397568,
0.12215952575206757,
-0.13813872635364532,
-0.16530241072177887,
-0.3301853835582733,
-0.08615490794181824,
0.10032635182142258,
0.2803803086280823,
0.24453438818454742,
0.16465607285499573,
0.12563036382198334,
0.17728471755981445,
0.1236155703663826,
0.18077339231967926,
-0.085635244846344,
0.06645327806472778,
0.0454605333507061,
0.026504889130592346,
-0.3276350498199463,
-0.034214917570352554,
0.11893706768751144,
-0.07509077340364456,
0.09080492705106735,
0.15633580088615417,
0.4426472783088684,
-0.09481555968523026,
0.12217872589826584,
-0.005244308616966009,
-0.03081301413476467,
-0.09265207499265671,
0.045755453407764435,
-0.15043728053569794,
-0.0027978357393294573,
-0.24135662615299225,
0.19415467977523804,
-0.05211346969008446,
-0.1464552879333496,
-0.1535523682832718,
0.0101053137332201,
0.09100402891635895,
0.14676998555660248,
0.06708110868930817,
-0.005730113014578819,
-0.08139541745185852,
-0.007282511796802282,
-0.016658127307891846,
0.23121130466461182,
0.2666957974433899,
0.037402693182229996,
-0.2830745577812195,
0.06662456691265106,
-0.1916557401418686,
-0.11929550766944885,
0.13842271268367767,
0.09067127853631973,
0.09044740349054337,
0.2870798707008362,
0.35722053050994873,
-0.07608701288700104,
-0.04016571864485741,
-0.06459211558103561,
0.08715032041072845,
-0.2415034919977188,
0.17462097108364105,
0.028316669166088104,
0.06071416661143303,
-0.08819443732500076,
-0.06127732992172241,
-0.2930189371109009,
0.0853201374411583,
-0.1361042708158493,
0.017791906371712685,
-0.12544874846935272,
0.1388804316520691,
-0.12714923918247223,
0.11703730374574661,
0.020211854949593544,
-0.13661646842956543,
0.17306014895439148,
-0.31791505217552185,
0.023918434977531433,
-0.28762057423591614,
-0.1347608119249344,
0.1131008118391037,
-0.2334713637828827,
0.01309474091976881,
0.24117398262023926,
-0.006242706906050444,
-0.01437421701848507,
0.08218280971050262,
-0.19149409234523773,
0.0625174343585968,
-0.028513669967651367,
-0.2894899845123291,
-0.17705486714839935,
0.14761489629745483,
-0.1956305205821991,
-0.1284930258989334,
0.03737582638859749,
0.04463670402765274,
0.31832465529441833,
-0.24945583939552307,
-0.08149731159210205,
-0.20836247503757477,
0.2223711907863617,
0.05786663666367531,
0.024116210639476776,
-0.3706314265727997,
0.09589897841215134,
0.13042742013931274,
-0.033981844782829285,
0.017694471403956413,
0.13714207708835602,
-0.18104702234268188,
-0.15526381134986877,
-0.04645884037017822,
0.09895549714565277,
0.07134532928466797,
0.07717941701412201,
0.09686772525310516,
0.023166608065366745,
-0.26236188411712646,
-0.24470050632953644,
0.037618573755025864,
-0.10390074551105499,
0.03776374086737633,
-0.021116191521286964,
-0.2132970541715622,
0.01651509292423725,
0.057021092623472214,
0.06443735957145691,
0.03406628966331482,
-0.047222379595041275,
-0.06576446443796158,
0.1557021588087082,
-0.23781713843345642,
-0.09441832453012466,
-0.10488137602806091,
0.19952644407749176,
0.1140872985124588,
0.09706823527812958,
-0.26183587312698364,
-0.08683064579963684,
0.11433357000350952,
0.09581112861633301,
-0.06672424077987671,
-0.07751966267824173,
-0.08827321976423264,
0.32348546385765076,
-0.08239933103322983,
0.07019034773111343,
0.05345407500863075,
0.17723485827445984,
-0.0512523427605629,
0.16092804074287415,
-0.1509566456079483,
0.0093619953840971,
0.12168180197477341,
0.13096708059310913,
-0.07090415805578232,
-0.046538520604372025,
0.1973663866519928,
0.11418163776397705,
-0.047102078795433044,
0.005044739227741957,
0.025679152458906174,
0.09229335933923721,
0.17655056715011597,
0.02844279445707798,
0.1043526902794838,
-0.17176486551761627,
-0.4400305449962616,
-0.05431125685572624,
-0.10964715480804443,
-0.08779822289943695,
0.29912394285202026,
0.1924186646938324,
0.03219408169388771,
-0.1404162496328354,
-0.27449434995651245,
0.04504998028278351,
-0.03027419187128544,
0.04790043830871582,
0.005034295842051506,
0.1609494984149933,
0.12226452678442001,
0.13683965802192688,
-0.030548442155122757,
0.010462084785103798,
0.12203317880630493,
0.017370687797665596,
-0.2749139070510864,
-0.012427395209670067,
0.002155228052288294,
-0.04760719835758209,
0.023851312696933746,
0.07919380813837051,
0.03182410076260567,
0.008170921355485916,
-0.11232157051563263,
-0.09299632161855698,
0.4431687295436859,
-0.12421423941850662,
0.269857257604599,
-0.04488588497042656,
-0.09317350387573242,
0.04175747558474541,
0.172463059425354,
-0.4743863344192505,
0.0038177038077265024,
-0.13092845678329468,
-0.17738234996795654,
-0.0830245092511177,
-0.08299821615219116,
0.24100466072559357,
0.1857302188873291,
-0.07198922336101532,
-0.14113447070121765,
0.11902862787246704,
-0.08962566405534744,
-0.32860705256462097,
0.17627616226673126,
-0.042082734405994415,
0.040823884308338165,
0.18574252724647522,
0.08592481911182404,
0.051337968558073044,
-0.12991517782211304,
-0.03598092496395111,
0.08261433243751526,
-0.003568741027265787,
0.13565504550933838,
-0.09607855975627899,
-0.0548231415450573,
0.093697689473629,
0.19774122536182404,
0.09033617377281189,
0.1105574443936348,
0.19130569696426392,
0.11576572805643082,
0.02763988822698593,
0.05042342096567154,
0.16097383201122284,
0.14635461568832397,
0.036086127161979675,
-0.3491985499858856,
-0.23276075720787048,
0.12017566710710526,
-0.0057320743799209595,
-0.03322847560048103,
-0.04988237842917442,
0.050459809601306915,
0.05806026607751846,
-0.09624876827001572,
0.2476300448179245,
0.16909538209438324,
-0.4578333795070648,
0.011064943857491016,
0.05485415831208229,
-0.00761043094098568,
0.060910940170288086,
0.01239614374935627,
0.09335000067949295,
0.027121838182210922,
-0.013722136616706848,
0.050752490758895874,
0.13807670772075653,
0.005404985509812832,
0.04847225919365883,
0.20849360525608063,
0.20419418811798096,
0.05914824455976486,
0.13554255664348602,
0.0024889882188290358,
0.014750171452760696,
-0.22204327583312988,
0.060004450380802155,
-0.01573573797941208,
-0.14812026917934418,
-0.05469688028097153,
-0.16465166211128235,
-0.08209001272916794,
-0.0802963525056839,
-0.14033322036266327,
0.14376495778560638,
0.02623686194419861,
0.054543547332286835,
0.09489686042070389,
0.0643298476934433,
0.015538321807980537,
-0.123540960252285,
-0.13920524716377258,
0.13920587301254272,
0.07194403558969498,
-0.07171410322189331,
0.10307055711746216,
0.13917547464370728,
0.28972920775413513,
0.12180440872907639,
-0.012176218442618847,
-0.03212224319577217,
-0.17802219092845917,
0.0784960687160492,
-0.3076515197753906,
0.061197590082883835,
-0.0021010672207921743,
-0.14394304156303406,
0.11409877240657806,
-0.013945278711616993,
-0.21067433059215546,
0.1699114888906479,
-0.21170324087142944,
0.08487500995397568,
0.07166598737239838,
0.3337186872959137,
0.038397837430238724,
0.16177690029144287,
0.1629188358783722,
-0.08128083497285843,
-0.15160934627056122,
-0.11079282313585281,
0.07694042474031448,
0.05262285843491554,
0.11256377398967743,
-0.08302367478609085,
0.012909971177577972,
-0.030678655952215195,
-0.2487880289554596,
0.22093600034713745,
0.28924211859703064,
-0.10763110220432281,
-0.1781749725341797,
0.12100867927074432,
-0.20685692131519318,
-0.07051754742860794,
0.07916136085987091,
0.007565026171505451,
-0.0003146673843730241,
0.08883297443389893,
-0.05391312763094902,
0.01724875718355179,
0.030052872374653816,
0.030439823865890503,
0.1066126599907875,
-0.022374121472239494,
-0.10224664956331253,
0.15090815722942352,
0.056379545480012894,
-0.09338165074586868,
0.10929574072360992,
-0.0008184111211448908,
-0.027369728311896324,
0.2134997546672821,
-0.13927507400512695,
0.06547074019908905,
0.1764354258775711,
-0.09003440290689468,
-0.028856251388788223,
-0.03457656875252724,
0.008411230519413948,
0.326419472694397,
-0.08563409000635147,
-0.19552811980247498,
-0.035297904163599014,
-0.1387951821088791,
-0.03825103119015694,
0.01496314350515604,
-0.011967823840677738,
-0.07199393957853317,
-0.01573553867638111,
0.029186541214585304,
-0.1379203349351883,
-0.03583173826336861,
0.000630670168902725,
0.02659299597144127,
-0.08627116680145264,
0.2123444676399231,
-0.0027055139653384686,
0.12795087695121765,
0.012135596014559269,
-0.00450544198974967,
0.1860308051109314,
-0.38108059763908386,
0.13857607543468475,
0.3945624530315399,
0.031211022287607193,
-0.05105262249708176,
0.10410451143980026,
-0.10915539413690567,
0.14406821131706238,
-0.04356398805975914,
0.10327563434839249,
-0.2008451372385025,
0.008565044030547142,
0.17925316095352173,
-0.028205040842294693,
0.0015296118799597025,
0.17612864077091217,
-0.12731577455997467,
-0.1014200821518898,
0.08845498412847519,
0.21714505553245544,
0.020852291956543922,
-0.012656386941671371,
-0.2556167542934418,
-0.10167650878429413,
-0.05061465874314308,
0.06359955668449402,
-0.16832219064235687,
0.03451380878686905,
-0.06144913285970688,
-0.3518622815608978,
0.30221712589263916,
0.17779357731342316,
0.19128118455410004,
0.25321003794670105,
-0.04829533025622368,
0.09310483187437057,
-0.13968846201896667,
0.1264442652463913,
0.10100103169679642,
0.03472346439957619,
-0.12324993312358856,
-0.2154100388288498,
-0.30515584349632263,
-0.17728979885578156,
-0.06072448566555977,
-0.07682566344738007,
-0.024230314418673515,
-0.2742510437965393,
0.0753805860877037,
-0.15471836924552917,
0.16869401931762695,
-0.11370531469583511,
-0.14000153541564941,
-0.15340815484523773,
-0.08838120102882385,
0.03883570060133934,
-0.025187283754348755,
0.1766681671142578,
-0.11061395704746246,
-0.011210945434868336,
0.18047946691513062,
-0.026795726269483566,
-0.33062759041786194,
-0.16767379641532898,
0.14243046939373016,
-0.04561903327703476,
-0.33263906836509705,
0.22233307361602783,
-0.02143924869596958,
0.15217654407024384,
-0.030313381925225258,
-0.09012008458375931,
0.1609000414609909,
0.30865707993507385,
-0.1080680713057518,
0.0017405498074367642,
-0.0868343934416771,
-0.03363842889666557,
0.05322816222906113,
-0.004451591055840254,
-0.09537041932344437,
0.28927934169769287,
-0.09348955005407333,
0.16050541400909424,
0.05942327529191971,
0.29918062686920166,
0.02446979098021984,
0.02367178536951542,
-0.14023219048976898,
-0.14165903627872467,
-0.1368338167667389,
0.2594303786754608,
-0.24200105667114258,
-0.1902550607919693,
0.038424745202064514,
0.09426067024469376,
-0.007239726837724447,
0.1755969375371933,
-0.06063912436366081,
-0.0387251190841198,
-0.0031529355328530073,
0.15544961392879486,
-0.013523228466510773,
0.17344339191913605,
-0.08317345380783081,
0.2658456265926361,
-0.09049911797046661,
0.13827520608901978,
-0.0762370377779007,
-0.047462575137615204,
0.1301906853914261,
-0.06328608095645905,
-0.15170305967330933,
0.05396421253681183,
-0.055918533354997635,
0.160195991396904,
0.35025691986083984,
-0.0023023048415780067,
-0.004395817872136831,
-0.05550341680645943,
-0.031057696789503098,
-0.0865488052368164,
-0.002312192926183343,
-0.23383095860481262,
0.26093775033950806,
-0.3174373209476471,
0.13932767510414124,
-0.031674355268478394,
0.03790358081459999,
-0.23072637617588043,
0.07552652806043625,
-0.0882379338145256,
-0.15944799780845642,
-0.002293157856911421,
-0.15746545791625977,
0.022549543529748917,
0.04782703518867493,
0.09430059790611267,
0.12365785986185074,
0.33548951148986816,
-0.23406586050987244,
0.17566266655921936,
-0.02906804531812668,
0.0717417374253273,
-0.15138539671897888,
0.018347913399338722,
0.0699305534362793,
0.13500867784023285,
-0.03010478802025318,
-0.15043200552463531,
0.15976335108280182,
0.054503537714481354,
-0.16060125827789307,
0.04976733773946762,
-0.21605823934078217,
-0.12570500373840332,
0.0806465670466423,
0.023465143516659737,
0.016006143763661385,
-0.004668180365115404,
0.18071989715099335,
0.0759265273809433,
0.24937433004379272,
-0.14330914616584778,
0.3221176266670227,
0.009693396277725697,
-0.3298725187778473,
-0.3070496916770935,
-0.001221816404722631,
0.11399880051612854,
0.1925148367881775,
0.04474255070090294,
-0.11468379199504852,
0.1591026484966278,
-0.3487243950366974,
0.0695423036813736,
-0.03749684989452362,
0.18633081018924713,
-0.048749230802059174,
-0.10323472321033478,
0.08013898134231567,
0.49811071157455444,
-0.11441094428300858,
-0.2716403901576996,
-0.22313405573368073,
-0.06936066597700119,
0.06934408098459244,
0.013633902184665203,
0.0370030552148819,
-0.12819534540176392,
-0.3043951690196991,
0.2864997386932373,
-0.1250080019235611,
0.11921267211437225,
-0.0854305773973465,
-0.24856439232826233,
-0.1754925698041916,
-0.11138734966516495,
0.21017195284366608,
-0.18522585928440094,
0.2169877290725708,
0.058695487678050995,
0.2580464780330658,
-0.11521796882152557,
-0.14949540793895721,
-0.001452757278457284,
0.02427239716053009,
0.11227604001760483,
-0.12284150719642639,
-0.005831594578921795,
0.016956452280282974,
-0.15048928558826447,
0.16638247668743134,
-0.06911177188158035,
0.06152050942182541,
-0.17685869336128235,
0.030325543135404587,
-0.3609587848186493,
-0.0379561148583889,
-0.08320511132478714,
0.05468825623393059,
0.007397852838039398,
-0.07786425203084946,
-0.05678192526102066,
-0.026972627267241478,
-0.13095085322856903,
0.17999455332756042,
0.08820977061986923,
-0.07648993283510208,
0.08600068837404251,
0.2860739827156067,
0.055562153458595276,
-0.12032435089349747,
-0.16684675216674805,
-0.10168903321027756,
0.1644899547100067,
0.2947819232940674,
0.056418269872665405,
0.08647045493125916,
-0.053055837750434875,
-0.11270064860582352,
-0.1481941193342209,
-0.08424865454435349,
0.12708453834056854,
-0.03293352574110031,
-0.11399215459823608,
0.0013488122494891286,
-0.04605880379676819,
0.05252653732895851,
-0.005703734699636698,
0.3622974157333374,
0.08754781633615494,
0.10729540139436722
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. Management of symptomatic hyperammonemic patients awaiting confirmatory testing can be particularly challenging and requires pursuit of several diagnostic considerations . Also see Baumgartner et al : Table 6.Evaluations Following Initial DiagnosisTo establish the extent of disease and needs of an individual diagnosed with PA the following evaluations are recommended (see Figure 2) if they have not already been completed:Blood gas with base balance, electrolytes with anion gap, glucose, plasma ammonia, calcium, phosphorus, urine ketonesPlasma amino acids, total and free carnitine and acylcarnitine profile, and urine organic acid analysisComplete blood count to evaluate for cytopeniasConsider initiating an evaluation for sepsis if the CBC and individual’s clinical signs suggest that infection is likelyAmylase and lipase to evaluate for pancreatitisConsultation with a clinical geneticist and/or genetic counselorOnce the patient becomes stable, evaluations include the following:Clinical assessment of growth parameters, ability to feed, the | [
-0.0927884578704834,
-0.018577130511403084,
-0.06864579021930695,
-0.2566157579421997,
-0.029491513967514038,
0.2206573188304901,
0.026353133842349052,
-0.21083998680114746,
-0.13085466623306274,
-0.09135112166404724,
0.11489095538854599,
0.045289475470781326,
-0.03747985139489174,
-0.008923644199967384,
-0.22107365727424622,
0.11393611878156662,
0.15265370905399323,
-0.1733601987361908,
-0.14675836265087128,
0.08458470553159714,
0.2193908989429474,
-0.07710877060890198,
-0.02881670370697975,
0.26021090149879456,
0.2014627903699875,
-0.10011658817529678,
0.2294883131980896,
-0.17338347434997559,
0.1972714364528656,
0.0818081870675087,
-0.24387036263942719,
-0.02635430172085762,
0.11830929666757584,
-0.16441284120082855,
-0.15799283981323242,
-0.18360869586467743,
-0.020301152020692825,
-0.2904086709022522,
0.03558635711669922,
-0.1757996529340744,
0.06570101529359818,
-0.16821222007274628,
0.36486709117889404,
0.08114434033632278,
0.0830303281545639,
-0.1648876965045929,
0.03045019321143627,
-0.19917719066143036,
-0.16691777110099792,
0.013760737143456936,
0.18533912301063538,
-0.11891686171293259,
-0.284786194562912,
0.02051815763115883,
0.14060939848423004,
-0.2940002679824829,
-0.2739512026309967,
-0.033624615520238876,
-0.09621652960777283,
0.022199515253305435,
0.089168019592762,
-0.13106532394886017,
-0.2649131715297699,
-0.13102905452251434,
0.07177214324474335,
-0.2008262276649475,
-0.07081691920757294,
0.16016462445259094,
0.26810261607170105,
-0.15070560574531555,
-0.01019186619669199,
-0.04468901827931404,
0.049962662160396576,
0.14836092293262482,
-0.05622246861457825,
0.08060740679502487,
0.06918749213218689,
-0.16129310429096222,
0.17520345747470856,
-0.3751010298728943,
-0.22276084125041962,
-0.034161850810050964,
0.00036835295031778514,
-0.09933986514806747,
-0.0793592631816864,
0.029461907222867012,
0.11368300020694733,
-0.04958675056695938,
-0.05629122629761696,
0.06153036653995514,
0.09763927012681961,
0.03411975875496864,
0.026438653469085693,
-0.0338129848241806,
0.14217053353786469,
-0.271579384803772,
0.2530825734138489,
0.049925126135349274,
-0.22138045728206635,
-0.013459507375955582,
0.06802978366613388,
0.19583000242710114,
-0.2201968878507614,
-0.19783614575862885,
-0.18872064352035522,
0.07466335594654083,
-0.2009076178073883,
-0.015698332339525223,
-0.09025321155786514,
0.002867479808628559,
0.1985034942626953,
-0.00535188103094697,
0.16817742586135864,
0.16487085819244385,
-0.483771413564682,
-0.16683626174926758,
0.03039688803255558,
0.28961309790611267,
-0.025350289419293404,
0.11043321341276169,
0.017276108264923096,
0.07464702427387238,
0.10707081854343414,
0.07264503836631775,
0.16316215693950653,
0.07260485738515854,
0.10011430084705353,
-0.24004648625850677,
0.14267590641975403,
-0.1346602886915207,
-0.02039266563951969,
0.10382380336523056,
0.12706194818019867,
-0.08141887187957764,
0.17026112973690033,
-0.013605478219687939,
-0.18291893601417542,
-0.2541048526763916,
0.07633113116025925,
0.06998202949762344,
0.22359460592269897,
0.2823713421821594,
0.17127422988414764,
0.11268811672925949,
0.16176185011863708,
0.01101112924516201,
0.28362876176834106,
-0.10445129126310349,
0.12265342473983765,
0.08099780976772308,
0.07628761976957321,
-0.3798660635948181,
-0.08582356572151184,
0.07896772772073746,
-0.07013043016195297,
0.14275777339935303,
0.15057331323623657,
0.39200952649116516,
-0.09445099532604218,
0.03739789500832558,
0.038189955055713654,
-0.0736793726682663,
0.02405114285647869,
0.10646897554397583,
-0.22525468468666077,
0.054474350064992905,
-0.18765537440776825,
0.08753687888383865,
-0.030611522495746613,
-0.01870519481599331,
-0.16303926706314087,
-0.03762659430503845,
0.06280777603387833,
0.10686955600976944,
0.14409179985523224,
-0.013279562816023827,
-0.06343019008636475,
-0.05304160714149475,
0.010048113763332367,
0.23421317338943481,
0.2904850244522095,
0.045566726475954056,
-0.28560972213745117,
-0.020493581891059875,
-0.1910279393196106,
-0.16015300154685974,
0.15420225262641907,
0.020802956074476242,
0.07516928762197495,
0.24896477162837982,
0.27785953879356384,
-0.04825242608785629,
-0.008522273041307926,
-0.07768843322992325,
-0.011163688264787197,
-0.2177407592535019,
0.09613968431949615,
0.004982569720596075,
0.040867071598768234,
-0.07607799023389816,
-0.03256672993302345,
-0.2664884328842163,
0.07771039754152298,
-0.20097669959068298,
-0.058137547224760056,
-0.09769110381603241,
0.19545340538024902,
-0.16332891583442688,
0.1010654866695404,
0.0010253654327243567,
-0.11534038186073303,
0.05154745653271675,
-0.21056190133094788,
0.011037621647119522,
-0.1800047904253006,
-0.033105481415987015,
0.08286216855049133,
-0.16791725158691406,
0.021682187914848328,
0.2724003493785858,
0.0028856981080025434,
0.08417979627847672,
0.12014871090650558,
-0.27387094497680664,
-0.02374156005680561,
-0.05017177760601044,
-0.16174009442329407,
-0.1906442791223526,
0.031030137091875076,
-0.13594695925712585,
-0.15416771173477173,
0.039499860256910324,
0.02679041400551796,
0.2749600410461426,
-0.2786594331264496,
-0.15693984925746918,
-0.2545580267906189,
0.1731267273426056,
0.03486788272857666,
0.050934743136167526,
-0.38900065422058105,
0.11805158853530884,
0.08395186066627502,
-0.008875276893377304,
0.10988237708806992,
0.06014801934361458,
-0.1807323396205902,
-0.0361732579767704,
-0.08106183260679245,
0.08429984003305435,
0.04233076423406601,
0.10153179615736008,
0.0034958738833665848,
0.0028663265984505415,
-0.2616330683231354,
-0.18375621736049652,
0.036349765956401825,
-0.08199310302734375,
-0.10891922563314438,
-0.0472540482878685,
-0.22568382322788239,
0.07095444947481155,
0.08940079808235168,
0.040794674307107925,
-0.006677297409623861,
-0.13663312792778015,
-0.05531297251582146,
0.07406608015298843,
-0.22423087060451508,
-0.09347127377986908,
-0.08212209492921829,
0.11323197185993195,
0.1570974439382553,
0.03251926228404045,
-0.18993330001831055,
-0.04562036320567131,
0.12076085805892944,
0.03715161979198456,
-0.009470600634813309,
-0.11548011004924774,
-0.18820680677890778,
0.37573808431625366,
-0.13202916085720062,
-0.002656285185366869,
0.06232920661568642,
0.22176478803157806,
-0.06841956824064255,
0.07184218615293503,
0.0000022782539872423513,
0.07263719290494919,
0.11984741687774658,
0.13827723264694214,
-0.06570027023553848,
0.00535467267036438,
0.12684808671474457,
0.011244202964007854,
-0.026630554348230362,
-0.03523360937833786,
0.0023298771120607853,
0.1088184118270874,
0.10540969669818878,
0.07757441699504852,
0.002533189719542861,
-0.1640215665102005,
-0.3711422383785248,
-0.02087666094303131,
-0.10202066600322723,
-0.022317811846733093,
0.38468828797340393,
0.16050934791564941,
-0.01699208654463291,
-0.1297987401485443,
-0.3016022741794586,
-0.0757160484790802,
0.01734268292784691,
0.0399237722158432,
0.1637972593307495,
0.10714074224233627,
0.13286082446575165,
0.12062885612249374,
0.02037114091217518,
0.04347097873687744,
0.053589291870594025,
-0.016078278422355652,
-0.2863589823246002,
-0.06225058063864708,
-0.14875027537345886,
-0.023538481444120407,
-0.11731540411710739,
0.003820328041911125,
0.13310647010803223,
0.0005576797411777079,
-0.10259808599948883,
-0.16882070899009705,
0.30076369643211365,
-0.11130846291780472,
0.25795361399650574,
0.10435040295124054,
-0.019659247249364853,
-0.09138473123311996,
0.21635234355926514,
-0.4544305205345154,
-0.05255558341741562,
-0.12013968825340271,
-0.05958476662635803,
-0.025943497195839882,
-0.07465378195047379,
0.17065727710723877,
0.11162813007831573,
-0.037670981138944626,
-0.11855752021074295,
0.1436372548341751,
0.02131596766412258,
-0.3043919801712036,
0.16770535707473755,
-0.037675607949495316,
0.09341643005609512,
0.15802504122257233,
0.05591045692563057,
0.135272815823555,
-0.17775261402130127,
0.05911010131239891,
-0.033634621649980545,
-0.024657875299453735,
0.11998515576124191,
-0.15940263867378235,
-0.10357582569122314,
0.09037173539400101,
0.22302590310573578,
0.08565367758274078,
0.1529364138841629,
0.10105025768280029,
0.11509199440479279,
0.03880927339196205,
-0.05440276861190796,
0.07892893254756927,
0.06121548265218735,
0.06312244385480881,
-0.2886679172515869,
-0.2435617744922638,
0.08061958104372025,
0.006693211384117603,
-0.08753624558448792,
-0.07834383845329285,
0.0309135802090168,
0.12419833242893219,
-0.09597352892160416,
0.14464274048805237,
0.12411977350711823,
-0.48576509952545166,
-0.041119322180747986,
0.0028274627402424812,
0.10149875283241272,
0.127584770321846,
0.1378505975008011,
0.1123662143945694,
0.08038149029016495,
-0.004400493111461401,
0.11138563603162766,
0.026026463136076927,
-0.030016670003533363,
0.10918360948562622,
0.24415069818496704,
0.08283539116382599,
0.009343120269477367,
0.13235719501972198,
0.05892955884337425,
-0.030580859631299973,
-0.18401870131492615,
0.0076306345872581005,
0.03265247866511345,
-0.08099349588155746,
-0.13502928614616394,
-0.16928304731845856,
0.02365870214998722,
-0.10972737520933151,
-0.17580583691596985,
0.20128607749938965,
-0.02967892773449421,
-0.028157182037830353,
0.10227060317993164,
0.10491945594549179,
0.11557742208242416,
-0.05276056006550789,
-0.19893419742584229,
0.1369931995868683,
-0.022316085174679756,
-0.011439095251262188,
0.17331281304359436,
0.20693786442279816,
0.2164251208305359,
-0.015052606351673603,
0.012819168157875538,
0.025204984471201897,
-0.20775653421878815,
0.003663538722321391,
-0.24667158722877502,
0.04957176372408867,
0.09937762469053268,
-0.18740208446979523,
0.17595098912715912,
-0.06495299935340881,
-0.18592628836631775,
0.2206350564956665,
-0.2009030282497406,
0.0865728110074997,
0.0655994564294815,
0.27470582723617554,
0.14045001566410065,
0.1549510359764099,
0.1837325245141983,
-0.0586424320936203,
-0.06102230027318001,
-0.057680871337652206,
0.11498485505580902,
-0.025686252862215042,
0.1737755537033081,
-0.04455123469233513,
-0.0385991670191288,
-0.06344666332006454,
-0.3255755603313446,
0.22460147738456726,
0.2398761808872223,
-0.03824340179562569,
-0.18329031765460968,
0.18902596831321716,
-0.13497698307037354,
-0.07194063067436218,
0.061419401317834854,
0.0024084399919956923,
-0.07957538962364197,
-0.03791395574808121,
-0.03820459917187691,
0.010860222391784191,
-0.0012638645712286234,
-0.04821651428937912,
0.09401357173919678,
-0.029531054198741913,
-0.1310773640871048,
0.24579916894435883,
0.04564199224114418,
-0.11520768702030182,
0.12327812612056732,
0.0943630114197731,
-0.015634741634130478,
0.14564186334609985,
-0.1878158003091812,
0.08768495917320251,
0.14963285624980927,
-0.0522691085934639,
-0.018454520031809807,
0.08428925275802612,
-0.06492150574922562,
0.37773391604423523,
-0.13821080327033997,
-0.17834463715553284,
-0.08397945016622543,
-0.17409776151180267,
-0.10362055897712708,
-0.018106548115611076,
0.046218857169151306,
0.008851510472595692,
0.009505098685622215,
-0.08273383229970932,
-0.14445281028747559,
-0.1422039121389389,
-0.05022754892706871,
-0.058209653943777084,
-0.10699284076690674,
0.11730027943849564,
-0.09162546694278717,
0.11568379402160645,
-0.01310628280043602,
0.02899802476167679,
0.11866264790296555,
-0.36409664154052734,
0.1315678507089615,
0.378773957490921,
-0.11082823574542999,
-0.08263210207223892,
0.08605168759822845,
-0.14565066993236542,
0.1488247960805893,
-0.06950375437736511,
0.04159514978528023,
-0.15339446067810059,
0.03624691441655159,
0.16412892937660217,
0.007832433097064495,
-0.026105549186468124,
0.10316552966833115,
-0.059541378170251846,
-0.1398201286792755,
0.025285843759775162,
0.21509210765361786,
-0.036202047020196915,
-0.05607755854725838,
-0.16791090369224548,
-0.15378156304359436,
-0.07569718360900879,
0.1826605498790741,
-0.16311024129390717,
0.15105539560317993,
-0.07815475761890411,
-0.3501925766468048,
0.2943055033683777,
0.1503797173500061,
0.20260809361934662,
0.1364639848470688,
-0.045985978096723557,
0.017392389476299286,
-0.21973097324371338,
0.13314786553382874,
0.10058773308992386,
-0.09765919297933578,
-0.09432961791753769,
-0.16469337046146393,
-0.28637415170669556,
-0.0900525227189064,
0.030475977808237076,
-0.09847579896450043,
-0.09613407403230667,
-0.24031034111976624,
0.021875781938433647,
-0.07662250101566315,
0.1448010951280594,
-0.09940654784440994,
-0.06496173143386841,
-0.09803219139575958,
-0.16963925957679749,
-0.013526295311748981,
-0.003995243459939957,
0.021382387727499008,
0.004027369432151318,
-0.06170262023806572,
0.16023820638656616,
-0.03113398887217045,
-0.32344886660575867,
-0.15160097181797028,
0.10464626550674438,
-0.09075053036212921,
-0.28320953249931335,
0.20625698566436768,
-0.05858442932367325,
0.14085699617862701,
-0.15995687246322632,
-0.1407167911529541,
0.10920584201812744,
0.2585469186306,
-0.23710711300373077,
-0.04037712514400482,
-0.0527791753411293,
-0.07102835923433304,
0.021413788199424744,
0.006780661176890135,
-0.16751164197921753,
0.23353582620620728,
-0.06325211375951767,
0.13018983602523804,
0.057765644043684006,
0.1687515377998352,
0.09577056765556335,
0.002196003682911396,
-0.2119780033826828,
-0.12945330142974854,
-0.08308379352092743,
0.16938330233097076,
-0.22546766698360443,
-0.051098424941301346,
-0.017213981598615646,
0.07886408269405365,
-0.001850189408287406,
0.18483760952949524,
-0.07475021481513977,
0.02742270939052105,
-0.06687188893556595,
0.20752321183681488,
0.0863131731748581,
0.11508528888225555,
-0.20291981101036072,
0.14829865097999573,
-0.03412399813532829,
0.09710390865802765,
-0.05572345107793808,
-0.03866927698254585,
0.07692974805831909,
0.008204538375139236,
-0.0639076754450798,
-0.041490040719509125,
-0.10000861436128616,
0.07976599782705307,
0.33314305543899536,
-0.06044291332364082,
-0.1265328973531723,
-0.1490403264760971,
-0.08758115023374557,
0.09777874499559402,
0.012383655644953251,
-0.25139904022216797,
0.11530452221632004,
-0.21562959253787994,
0.1290193349123001,
-0.0511271096765995,
0.10821620374917984,
-0.22591526806354523,
0.013086595572531223,
-0.0857226774096489,
-0.2426374852657318,
-0.0570952445268631,
-0.09456164389848709,
0.010166723281145096,
0.0777338296175003,
0.09817632287740707,
-0.05467228963971138,
0.2824156880378723,
-0.22339077293872833,
0.26315608620643616,
0.050652336329221725,
0.12737604975700378,
-0.11749643087387085,
0.07695980370044708,
0.008745744824409485,
0.1463501751422882,
0.014623522758483887,
-0.1546855866909027,
0.02317982353270054,
0.18510955572128296,
-0.08335600048303604,
0.0931830182671547,
-0.17714077234268188,
-0.2339349389076233,
0.04080015420913696,
-0.06502162665128708,
0.05030888319015503,
-0.02058539353311062,
0.1765323132276535,
-0.029103251174092293,
0.2530592978000641,
-0.06189470738172531,
0.26764732599258423,
0.09154046326875687,
-0.3443593382835388,
-0.19671368598937988,
-0.15265808999538422,
0.022890664637088776,
0.1768239289522171,
0.05963590741157532,
-0.08561447262763977,
0.11557390540838242,
-0.2860018312931061,
-0.0132760526612401,
-0.097384512424469,
0.15200622379779816,
-0.05023299157619476,
-0.050822749733924866,
0.044903215020895004,
0.49560990929603577,
-0.13108545541763306,
-0.3694436550140381,
-0.0885898768901825,
-0.05588611215353012,
-0.010478245094418526,
-0.03492509946227074,
0.020878441631793976,
-0.20963343977928162,
-0.2471577674150467,
0.26261866092681885,
-0.15149153769016266,
0.09418326616287231,
-0.020923232659697533,
-0.18679030239582062,
-0.13146911561489105,
-0.1445249319076538,
0.1922449916601181,
-0.12167732417583466,
0.16801512241363525,
0.13020220398902893,
0.2595394253730774,
-0.012777571566402912,
-0.1526940017938614,
-0.058396562933921814,
-0.015864867717027664,
-0.04516775533556938,
-0.07007128745317459,
0.04274618625640869,
-0.01263588760048151,
-0.2509506940841675,
0.10171300917863846,
-0.018163159489631653,
-0.014416635036468506,
-0.20069646835327148,
-0.013880394399166107,
-0.24900344014167786,
-0.1516118049621582,
-0.017617495730519295,
0.0026772695127874613,
0.06365734338760376,
-0.10394564270973206,
-0.01352577842772007,
-0.023751795291900635,
-0.08684045821428299,
0.1679769903421402,
0.16120432317256927,
-0.0590478777885437,
0.036808375269174576,
0.2673306465148926,
-0.020264165475964546,
-0.19536174833774567,
-0.20194965600967407,
-0.12254718691110611,
0.22134259343147278,
0.2825230062007904,
0.026578355580568314,
0.08757185935974121,
-0.0017026289133355021,
-0.09495822340250015,
-0.1309596449136734,
-0.05343616008758545,
0.08952304720878601,
-0.05416165664792061,
-0.13544195890426636,
-0.010707798413932323,
0.015074366703629494,
0.06920897960662842,
-0.041825708001852036,
0.3578491806983948,
0.1521407812833786,
0.23447708785533905
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. Plasma amino acids, total and free carnitine and acylcarnitine profile, and urine organic acid analysisComplete blood count to evaluate for cytopeniasConsider initiating an evaluation for sepsis if the CBC and individual’s clinical signs suggest that infection is likelyAmylase and lipase to evaluate for pancreatitisConsultation with a clinical geneticist and/or genetic counselorOnce the patient becomes stable, evaluations include the following:Clinical assessment of growth parameters, ability to feed, the need for G-tube placement, and neurologic status.Laboratory assessment of nutritional status (calcium, phosphorus, albumin, prealbumin, plasma amino acids, vitamin levels , iron panel, and minerals and renal function); complete blood count to monitor for cytopeniasClinical evaluation for cardiomyopathy and arrhythmia with ECG, 24-hour Holter monitor, echocardiogramEEG and brain MRI in symptomatic individualsDevelopmental evaluationDilated eye examinationHearing evaluationImmunology consultOtherComplet | [
-0.0072954874485731125,
0.07744596153497696,
-0.08630914241075516,
-0.26382628083229065,
-0.00349829182960093,
0.11799044907093048,
-0.0434848889708519,
-0.17420968413352966,
-0.10902200639247894,
-0.03285219892859459,
0.0470280721783638,
0.1184317097067833,
-0.060453057289123535,
0.07643086463212967,
-0.33111512660980225,
0.16578225791454315,
0.07281079888343811,
-0.0772882029414177,
-0.054345618933439255,
-0.05483400076627731,
0.16135941445827484,
-0.17680001258850098,
0.1062394380569458,
0.11193373799324036,
0.12359599024057388,
-0.0945042222738266,
0.17994505167007446,
-0.1614246368408203,
0.23216165602207184,
0.01804918795824051,
-0.09882217645645142,
-0.0864599347114563,
0.061311665922403336,
-0.18080011010169983,
-0.06704254448413849,
-0.2734416723251343,
-0.0752536803483963,
-0.23094068467617035,
-0.06384370476007462,
-0.10797760635614395,
-0.09479144215583801,
-0.11265632510185242,
0.405292272567749,
-0.07674767076969147,
0.20070214569568634,
-0.10647816956043243,
0.05660894140601158,
-0.1818089783191681,
-0.10978495329618454,
0.10089056193828583,
0.04714363068342209,
-0.12211571633815765,
-0.18160328269004822,
-0.0867076963186264,
0.20646686851978302,
-0.22856289148330688,
-0.20068077743053436,
0.024757130071520805,
-0.14185316860675812,
0.18499021232128143,
0.2201233208179474,
-0.0897180587053299,
-0.2019428312778473,
-0.2184317409992218,
0.10595338046550751,
-0.08530127257108688,
-0.11818887293338776,
0.08930235356092453,
0.29047495126724243,
-0.039951834827661514,
-0.0030905548483133316,
-0.08860626816749573,
-0.010492364875972271,
0.14268390834331512,
-0.06720235198736191,
0.0805673822760582,
0.1266797035932541,
-0.03776705637574196,
0.17760583758354187,
-0.48056331276893616,
-0.2795526683330536,
-0.00689223688095808,
-0.12250363826751709,
-0.09351690858602524,
-0.13184410333633423,
0.15659163892269135,
0.10072872787714005,
-0.07237759232521057,
0.010842920280992985,
0.0558268241584301,
0.15129736065864563,
-0.01991422101855278,
-0.002423068741336465,
-0.11611049622297287,
0.061814215034246445,
-0.17684388160705566,
0.24418561160564423,
0.08726222068071365,
-0.1503608375787735,
0.059747274965047836,
0.05914461612701416,
0.10891418159008026,
-0.09885753691196442,
-0.15139693021774292,
-0.043924156576395035,
-0.06219159811735153,
-0.29998084902763367,
0.11177235096693039,
-0.047030385583639145,
-0.030942440032958984,
0.06851895898580551,
-0.058870572596788406,
0.0978674665093422,
0.061313193291425705,
-0.3308670222759247,
0.014623945578932762,
0.07264366000890732,
0.26756981015205383,
0.01040088851004839,
0.1520095318555832,
0.0017981582786887884,
0.04093201458454132,
0.06519603729248047,
-0.009619507007300854,
0.23972399532794952,
0.06806381791830063,
0.1185322254896164,
-0.0265587717294693,
0.002636483171954751,
-0.032251689583063126,
-0.039547037333250046,
0.07788784801959991,
0.12858305871486664,
-0.12718597054481506,
0.07002108544111252,
-0.05304183065891266,
-0.2150697410106659,
-0.36240890622138977,
-0.007555732503533363,
0.032644908875226974,
0.19282226264476776,
0.2609884440898895,
0.16861283779144287,
0.12176931649446487,
0.07232862710952759,
0.03546217456459999,
0.39172643423080444,
-0.06030258536338806,
0.16000036895275116,
0.1374654471874237,
0.11499949544668198,
-0.24963954091072083,
0.10166070610284805,
0.029031813144683838,
-0.008549381978809834,
0.1082586795091629,
0.0906011238694191,
0.3280434012413025,
-0.12322525680065155,
0.03222612664103508,
0.003366336226463318,
-0.12041804194450378,
0.10317805409431458,
0.04559529572725296,
-0.044421061873435974,
0.05301051586866379,
-0.2531150281429291,
0.09352871030569077,
0.004254222847521305,
-0.06345999985933304,
-0.09020443260669708,
-0.030314384028315544,
0.01926969364285469,
0.13207879662513733,
0.08344274014234543,
0.13499616086483002,
-0.04878024756908417,
-0.10829345881938934,
-0.13895325362682343,
0.08020267635583878,
0.22873513400554657,
-0.11883904784917831,
-0.343014121055603,
-0.0612974539399147,
-0.01077800802886486,
-0.0285501666367054,
0.1331672966480255,
0.12010814249515533,
-0.033876933157444,
0.20689208805561066,
0.25566190481185913,
0.06323303282260895,
-0.10081379860639572,
0.08466023951768875,
-0.17302434146404266,
-0.17569436132907867,
0.02208249270915985,
0.0386839359998703,
-0.04758330062031746,
-0.10502079874277115,
0.05042519420385361,
-0.19183900952339172,
0.19409000873565674,
-0.19824889302253723,
-0.023432910442352295,
-0.13997283577919006,
0.08400002121925354,
-0.25573602318763733,
0.1022455021739006,
-0.02710767649114132,
0.005512789357453585,
0.08826329559087753,
-0.10006707906723022,
0.0907382145524025,
-0.14513961970806122,
-0.05067148804664612,
0.05796900391578674,
-0.09255167841911316,
-0.07454237341880798,
0.11280470341444016,
0.03710152953863144,
0.037943340837955475,
-0.021397767588496208,
-0.2196613997220993,
-0.09175389260053635,
0.012929783202707767,
-0.1840842217206955,
-0.16384407877922058,
0.0737789198756218,
-0.09445007890462875,
-0.1919267624616623,
0.022564547136425972,
0.04597862809896469,
0.2981303334236145,
-0.13162903487682343,
-0.10695606470108032,
-0.1996200531721115,
0.2623896300792694,
0.05342775583267212,
-0.1340528130531311,
-0.3272678852081299,
-0.002246884861961007,
0.03184033930301666,
-0.05215885862708092,
0.07226534932851791,
0.224357470870018,
-0.09046100080013275,
0.16657206416130066,
-0.09229448437690735,
0.01930026337504387,
0.130681574344635,
0.15857721865177155,
0.055484838783741,
0.10741721838712692,
-0.2914655804634094,
-0.20146937668323517,
0.004175981506705284,
0.016655225306749344,
-0.11087857186794281,
0.064358651638031,
-0.20516622066497803,
0.03491343930363655,
0.20635445415973663,
0.07152394950389862,
-0.09270372241735458,
-0.036523062735795975,
-0.10351569950580597,
0.0004996774368919432,
-0.12853075563907623,
-0.11366981267929077,
-0.01723163016140461,
0.052690181881189346,
0.18262003362178802,
0.08683907985687256,
-0.27505505084991455,
-0.14545558393001556,
0.05965084210038185,
-0.04857254400849342,
0.017186185345053673,
-0.040141597390174866,
-0.10779036581516266,
0.18704764544963837,
-0.09654231369495392,
-0.009952294640243053,
-0.04233906418085098,
0.1008872538805008,
0.008356357924640179,
0.09759697318077087,
-0.059783272445201874,
0.17648611962795258,
0.049206290394067764,
0.05852599814534187,
-0.12125514447689056,
0.07895194739103317,
0.08535099774599075,
0.06673713028430939,
-0.06468179821968079,
0.052738215774297714,
0.12287033349275589,
0.028338609263300896,
0.07985948771238327,
0.14391446113586426,
0.1172223910689354,
-0.09063618630170822,
-0.2569864094257355,
-0.027336806058883667,
-0.008503000251948833,
-0.044263001531362534,
0.32848477363586426,
0.14645491540431976,
-0.043481696397066116,
-0.1140359416604042,
-0.2623961269855499,
-0.12195033580064774,
0.0673188790678978,
0.01351074781268835,
0.010249756276607513,
0.07862576097249985,
0.15528234839439392,
0.05336485803127289,
0.009157647378742695,
-0.01296916138380766,
0.07946330308914185,
0.06870962679386139,
-0.2716772258281708,
-0.060852162539958954,
-0.127467080950737,
0.06579353660345078,
-0.0645550936460495,
0.0752255991101265,
-0.07815385609865189,
0.06287690252065659,
-0.07542464882135391,
-0.10707927495241165,
0.3067706227302551,
-0.17948146164417267,
0.194382905960083,
0.19823448359966278,
-0.004302364308387041,
-0.03679889813065529,
0.19907937943935394,
-0.32570433616638184,
-0.07869206368923187,
-0.1750674992799759,
-0.19681763648986816,
0.1434633880853653,
0.05930100381374359,
0.030907781794667244,
0.06468342989683151,
-0.0051163556054234505,
-0.14555105566978455,
0.17380255460739136,
-0.028874311596155167,
-0.13502256572246552,
0.1600082665681839,
-0.07824664562940598,
-0.03575246036052704,
0.06818244606256485,
0.1644972413778305,
0.13878117501735687,
-0.3152788579463959,
0.11455924808979034,
0.039693329483270645,
-0.007618044503033161,
0.19986547529697418,
-0.13154718279838562,
-0.21705283224582672,
0.004201184026896954,
0.22200295329093933,
0.07360850274562836,
0.19178514182567596,
0.0845114141702652,
0.07622955739498138,
0.14974908530712128,
0.04651888832449913,
0.14179299771785736,
-0.060558777302503586,
0.039800431579351425,
-0.2651562988758087,
-0.11966843903064728,
0.11719878017902374,
0.09246731549501419,
0.06184619292616844,
-0.058258529752492905,
-0.07194750010967255,
0.18175475299358368,
0.016903016716241837,
0.06301438808441162,
0.03372855857014656,
-0.43175259232521057,
-0.13007889688014984,
0.07981713861227036,
0.21241331100463867,
0.21666796505451202,
0.10822182148694992,
0.05273846164345741,
0.07345274835824966,
0.07713747024536133,
0.0012008867925032973,
-0.05920051410794258,
-0.05869723856449127,
0.05437267944216728,
0.2917156517505646,
-0.005611957982182503,
0.0811169296503067,
0.13091959059238434,
0.16965557634830475,
0.13825538754463196,
-0.16090011596679688,
-0.0047677927650511265,
0.05088576674461365,
-0.1459333896636963,
-0.11883892118930817,
-0.13505081832408905,
-0.02196858637034893,
-0.07090297341346741,
-0.18207819759845734,
0.08530846983194351,
0.024420619010925293,
-0.09506601095199585,
0.00034020657767541707,
-0.018154382705688477,
0.08641965687274933,
0.007165222894400358,
-0.21911217272281647,
0.14488081634044647,
0.023562146350741386,
-0.06387495994567871,
0.08220324665307999,
0.09033789485692978,
0.22466684877872467,
-0.014978369697928429,
-0.03399189934134483,
0.11152828484773636,
-0.0003910248924512416,
0.12149647623300552,
-0.16151775419712067,
-0.05147634446620941,
0.17942051589488983,
-0.2640461325645447,
0.16020137071609497,
-0.0851798728108406,
-0.05834322050213814,
0.12002933770418167,
-0.08220626413822174,
0.06721659749746323,
0.10394895076751709,
0.19043521583080292,
0.17870405316352844,
0.1062353327870369,
0.24299712479114532,
-0.09255039691925049,
0.08436553925275803,
-0.008018487133085728,
0.07326231896877289,
0.029528675600886345,
0.16785801947116852,
-0.09064161032438278,
-0.10253704339265823,
-0.06356967985630035,
-0.27038341760635376,
0.22492298483848572,
0.19167082011699677,
0.0029634321108460426,
-0.12651963531970978,
0.10710586607456207,
-0.19437433779239655,
-0.04525221511721611,
0.07230617105960846,
-0.0544312559068203,
-0.04132289066910744,
0.018483923748135567,
-0.02690931223332882,
0.10045627504587173,
-0.058674924075603485,
-0.15379005670547485,
0.12999171018600464,
0.010447153821587563,
0.004319644067436457,
0.11387869715690613,
-0.009354914538562298,
-0.24879366159439087,
0.05438622087240219,
0.20598067343235016,
-0.07587029784917831,
0.11412743479013443,
-0.20565475523471832,
0.024211714044213295,
0.16297654807567596,
-0.016240639612078667,
-0.01891889050602913,
-0.023045599460601807,
-0.1612652987241745,
0.35733479261398315,
-0.12257380038499832,
-0.23335351049900055,
-0.10300977528095245,
-0.13056503236293793,
-0.05321943014860153,
-0.060691818594932556,
0.043114468455314636,
-0.07938002049922943,
-0.16307267546653748,
-0.02898566983640194,
-0.14596661925315857,
-0.14741076529026031,
0.04077725484967232,
-0.12075305730104446,
-0.04966087266802788,
0.08572741597890854,
-0.058390308171510696,
0.06707055121660233,
-0.038488976657390594,
0.0854027047753334,
0.06631631404161453,
-0.3745952546596527,
0.061114564538002014,
0.24513491988182068,
-0.16379491984844208,
-0.0599541962146759,
0.11871953308582306,
-0.051583077758550644,
0.10640377551317215,
-0.0262813251465559,
0.05853939428925514,
-0.048803769052028656,
-0.021951649338006973,
0.062443461269140244,
0.031183436512947083,
-0.0018303846009075642,
0.034161075949668884,
-0.11718376725912094,
-0.13951747119426727,
-0.08241398632526398,
0.22834649682044983,
-0.1623646765947342,
-0.016808632761240005,
-0.03175137937068939,
-0.12418746948242188,
-0.13238638639450073,
0.04477480798959732,
-0.006960265804082155,
0.08328640460968018,
0.04264296591281891,
-0.21493278443813324,
0.21662801504135132,
0.1542518436908722,
0.1863197237253189,
0.07477229088544846,
0.011345391161739826,
0.03494156897068024,
-0.2652336061000824,
0.042596619576215744,
0.15027597546577454,
-0.08341711014509201,
-0.13412313163280487,
-0.1645047515630722,
-0.15172943472862244,
-0.1537228673696518,
0.1590045988559723,
-0.08023590594530106,
-0.1327843964099884,
-0.20218758285045624,
-0.0005254735588096082,
-0.01074757520109415,
0.18439117074012756,
-0.10118842124938965,
-0.1477106213569641,
-0.045789144933223724,
-0.019603068009018898,
0.026273712515830994,
0.09469201415777206,
0.032095253467559814,
-0.005993569269776344,
-0.0960640162229538,
0.12740248441696167,
-0.007644752040505409,
-0.3661477863788605,
-0.13313183188438416,
0.051750216633081436,
-0.0058228387497365475,
-0.12974058091640472,
0.17730915546417236,
-0.12513476610183716,
0.15416279435157776,
-0.10823587328195572,
-0.10962529480457306,
0.12067962437868118,
0.2754821479320526,
-0.17728333175182343,
0.07809504866600037,
0.0017103827558457851,
0.0021794734057039022,
-0.00816430151462555,
0.12676307559013367,
-0.12185575067996979,
0.2489612102508545,
-0.15747299790382385,
0.04116569086909294,
-0.02289222739636898,
0.03913626819849014,
0.205558642745018,
-0.0714259222149849,
-0.23060564696788788,
-0.12841036915779114,
-0.18418468534946442,
0.1372937709093094,
-0.21293550729751587,
-0.041037771850824356,
-0.08993647247552872,
0.15115289390087128,
-0.01849796622991562,
0.23170402646064758,
-0.05260889604687691,
0.01670980453491211,
-0.021146127954125404,
0.1788468360900879,
0.13564236462116241,
0.1081225723028183,
-0.10939732193946838,
0.146593376994133,
0.011529125273227692,
0.07571858912706375,
-0.08681978285312653,
-0.051350053399801254,
0.08104029297828674,
-0.01905590482056141,
0.0473545677959919,
-0.03689282014966011,
-0.12096478790044785,
-0.04100353643298149,
0.21296623349189758,
0.02248464897274971,
-0.12283853441476822,
-0.1516321301460266,
-0.08047414571046829,
0.11049052327871323,
0.0014860581140965223,
-0.16102448105812073,
-0.01995275914669037,
-0.09917601197957993,
0.1566738784313202,
-0.13126234710216522,
0.07667969167232513,
-0.12620095908641815,
0.02027158997952938,
-0.07482101023197174,
-0.30913570523262024,
-0.15079812705516815,
-0.03634249046444893,
-0.08376193046569824,
-0.0025711955968290567,
-0.0768931433558464,
-0.00557955214753747,
0.24206817150115967,
-0.12178729474544525,
0.1989627480506897,
0.12408231943845749,
0.22220517694950104,
-0.03811824321746826,
0.08788350224494934,
-0.008080822415649891,
0.14461027085781097,
0.061064522713422775,
-0.04479478299617767,
-0.030653052031993866,
0.18783721327781677,
0.026806917041540146,
0.01730216294527054,
-0.13496294617652893,
-0.2770127058029175,
0.038335975259542465,
-0.09583427757024765,
0.09458968788385391,
0.03403925523161888,
0.22933878004550934,
-0.00020399635832291096,
0.10963109135627747,
-0.20593112707138062,
0.192796990275383,
0.10448870062828064,
-0.3544003665447235,
-0.08615688979625702,
-0.23985891044139862,
0.008179395459592342,
0.1477249264717102,
0.028578877449035645,
-0.14735077321529388,
0.12513959407806396,
-0.23562686145305634,
0.02729334495961666,
-0.1221325695514679,
0.10938675701618195,
0.10462253540754318,
-0.11161042749881744,
-0.04580698162317276,
0.35404956340789795,
-0.24422472715377808,
-0.27646806836128235,
0.013429502956569195,
0.032312873750925064,
-0.08672375977039337,
-0.03948037698864937,
0.026554781943559647,
-0.1582929491996765,
-0.09608258306980133,
0.10159847885370255,
-0.15793687105178833,
0.023797623813152313,
0.04481595382094383,
-0.2517051100730896,
-0.009080617688596249,
-0.18568827211856842,
0.042149268090724945,
-0.012372463941574097,
0.07057671993970871,
0.11849057674407959,
0.2455950677394867,
-0.06065099686384201,
-0.17051300406455994,
-0.044604022055864334,
0.09579353779554367,
0.00960592646151781,
-0.08359870314598083,
0.036129023879766464,
-0.04236830025911331,
-0.19843314588069916,
0.056162428110837936,
0.19214430451393127,
-0.025420337915420532,
-0.12679423391819,
-0.0661187395453453,
-0.19220662117004395,
-0.14139783382415771,
-0.05230226740241051,
0.07205788046121597,
0.030501767992973328,
-0.0594056099653244,
0.0424530990421772,
-0.05455223098397255,
-0.06513073295354843,
0.0392703041434288,
0.18499988317489624,
-0.08832287788391113,
0.023038187995553017,
0.1904408484697342,
0.009514974430203438,
-0.17430095374584198,
-0.048514556139707565,
-0.016134675592184067,
0.14952246844768524,
0.14110225439071655,
0.10408226400613785,
0.1445149928331375,
-0.021834157407283783,
-0.007984323427081108,
-0.21710842847824097,
-0.23297670483589172,
-0.03992999345064163,
0.02325586788356304,
-0.029965605586767197,
0.0007932678563520312,
-0.015103313140571117,
0.13364481925964355,
-0.15755440294742584,
0.2703567445278168,
0.1222839429974556,
0.22708441317081451
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. , ability to feed, the need for G-tube placement, and neurologic status.Laboratory assessment of nutritional status (calcium, phosphorus, albumin, prealbumin, plasma amino acids, vitamin levels , iron panel, and minerals and renal function); complete blood count to monitor for cytopeniasClinical evaluation for cardiomyopathy and arrhythmia with ECG, 24-hour Holter monitor, echocardiogramEEG and brain MRI in symptomatic individualsDevelopmental evaluationDilated eye examinationHearing evaluationImmunology consultOtherComplete adherence to regional immunization schedules and influenza vaccination is indicated .Maintain a high index of suspicion for endocrine, immune, and renal problems and address accordingly.Treatment of ManifestationsNeonatal/acute decompensation. Birth, infections, trauma, surgery, postpartum recovery, or other forms of stress and hormonal changes can result in a catabolic response that leads, among other things, to protein breakdown with release of propiogenic amino acids that cannot be metabolized in PA. The goal of | [
-0.06080770865082741,
0.04497574269771576,
-0.17765185236930847,
-0.1836889088153839,
0.014755367301404476,
0.016385983675718307,
-0.06874177604913712,
-0.20050659775733948,
-0.08143193274736404,
-0.08927518129348755,
0.10094153881072998,
0.0534391924738884,
0.025430411100387573,
0.0959039106965065,
-0.30638396739959717,
0.10418986529111862,
-0.030761944130063057,
-0.08743109554052353,
0.07187677919864655,
-0.07124679535627365,
0.21378274261951447,
-0.19521702826023102,
0.11422099173069,
0.12420825660228729,
0.10894294828176498,
-0.031404197216033936,
0.16376155614852905,
-0.22942888736724854,
0.27338698506355286,
0.019328253343701363,
-0.006803409196436405,
-0.03193202614784241,
0.04619977995753288,
-0.23166845738887787,
-0.1322568953037262,
-0.2481856495141983,
-0.0066114915534853935,
-0.26073139905929565,
-0.030618682503700256,
-0.09209173917770386,
-0.043820321559906006,
-0.18752945959568024,
0.301361083984375,
-0.052765052765607834,
0.11401905864477158,
-0.055812984704971313,
0.13071249425411224,
-0.19926439225673676,
-0.1172422468662262,
0.16781020164489746,
-0.014075840823352337,
-0.1440429538488388,
-0.20177724957466125,
-0.1656121164560318,
0.2588105797767639,
-0.10364310443401337,
-0.1351264864206314,
0.019714828580617905,
-0.09553831815719604,
0.26086369156837463,
0.24934880435466766,
-0.13389398157596588,
-0.23139044642448425,
-0.3139725923538208,
0.12322370707988739,
0.021938366815447807,
-0.10504326969385147,
0.06722519546747208,
0.3213008940219879,
-0.0038524926640093327,
0.02181580290198326,
-0.10830263793468475,
-0.006451520603150129,
0.16456493735313416,
-0.10342162847518921,
0.026669180020689964,
0.14179888367652893,
-0.056265998631715775,
0.13992266356945038,
-0.40698832273483276,
-0.2948741912841797,
0.003416636725887656,
-0.0930783599615097,
-0.14116711914539337,
-0.1570962518453598,
0.008898450993001461,
0.13727031648159027,
-0.048907406628131866,
-0.02214686945080757,
0.025438763201236725,
0.12424985319375992,
0.023924820125102997,
-0.11593470722436905,
-0.06044686213135719,
-0.01770164631307125,
-0.17020028829574585,
0.19646361470222473,
0.09571295976638794,
-0.11345620453357697,
0.11844510585069656,
0.023118527606129646,
0.10082842409610748,
-0.06833089143037796,
-0.13927392661571503,
0.013469119556248188,
-0.06224534288048744,
-0.2915825843811035,
0.05708865821361542,
-0.1425817310810089,
-0.06649471819400787,
0.08314890414476395,
-0.09288354218006134,
0.15268200635910034,
0.03613479435443878,
-0.3346101641654968,
-0.0538938045501709,
0.06979062408208847,
0.261778324842453,
0.0881471112370491,
0.12163957953453064,
0.0928322821855545,
0.16056716442108154,
0.0838036984205246,
-0.020554160699248314,
0.2166992723941803,
0.038347117602825165,
0.14614395797252655,
0.06957343965768814,
0.025256605818867683,
0.017239706590771675,
-0.0001267168263439089,
-0.01658967323601246,
0.09077411144971848,
-0.12503954768180847,
0.12060987949371338,
-0.11574951559305191,
-0.18759453296661377,
-0.30388543009757996,
-0.011663458310067654,
0.15768586099147797,
0.2079901248216629,
0.23944292962551117,
0.13638417422771454,
0.13762712478637695,
0.05125253647565842,
-0.0011661241296678782,
0.3832961916923523,
0.08453990519046783,
0.11743934452533722,
0.11402768641710281,
0.09498947858810425,
-0.2299734503030777,
0.11047357320785522,
0.041701626032590866,
0.05491743981838226,
0.10115598142147064,
-0.0015792171470820904,
0.30739209055900574,
-0.1544773131608963,
-0.0762500911951065,
0.06056506559252739,
-0.04796232283115387,
0.07488279789686203,
0.09489887952804565,
-0.04979259893298149,
0.14066070318222046,
-0.2165728360414505,
0.10425665229558945,
0.06527106463909149,
-0.041888315230607986,
-0.04863743484020233,
0.041960328817367554,
-0.07304273545742035,
0.09635591506958008,
-0.005052617751061916,
0.18983888626098633,
-0.061398085206747055,
-0.14748775959014893,
-0.0865042582154274,
0.04885492101311684,
0.2651260495185852,
-0.17094282805919647,
-0.28964850306510925,
-0.11699874699115753,
0.025858327746391296,
-0.05007735639810562,
0.15964190661907196,
0.16604794561862946,
0.004894563928246498,
0.2563255727291107,
0.23935283720493317,
0.12155793607234955,
-0.23379658162593842,
0.12313961237668991,
-0.10904818773269653,
-0.23257452249526978,
0.09692399203777313,
0.09839440137147903,
-0.04481363669037819,
-0.14318978786468506,
0.04205791652202606,
-0.27994847297668457,
0.17672760784626007,
-0.22639715671539307,
-0.048847418278455734,
-0.12469440698623657,
-0.02745794877409935,
-0.2480558156967163,
0.11230891197919846,
-0.040285736322402954,
0.033613983541727066,
0.12184348702430725,
-0.0384628102183342,
0.05768170207738876,
-0.16025614738464355,
0.014638380147516727,
-0.03680076450109482,
-0.04076701030135155,
-0.12988731265068054,
0.07454860955476761,
-0.04145096614956856,
-0.0006849846104159951,
-0.037179600447416306,
-0.23851454257965088,
-0.18806269764900208,
0.10797248035669327,
-0.21124279499053955,
-0.13482503592967987,
0.08304691314697266,
-0.06586457043886185,
-0.19310247898101807,
0.08669540286064148,
0.03872879222035408,
0.23393821716308594,
-0.14100611209869385,
-0.006653318181633949,
-0.18519015610218048,
0.31952103972435,
0.09422335028648376,
-0.08478108048439026,
-0.38845425844192505,
0.0035828000400215387,
0.1398625522851944,
-0.06340479850769043,
0.11205565929412842,
0.13791869580745697,
0.015812911093235016,
0.14262568950653076,
-0.16473911702632904,
-0.030054662376642227,
0.02599538303911686,
0.02841075323522091,
-0.03231673315167427,
0.03469940274953842,
-0.32416555285453796,
-0.058004457503557205,
0.12514637410640717,
-0.06766372174024582,
-0.1274149864912033,
-0.034971822053194046,
-0.15818770229816437,
0.013832496479153633,
0.16227035224437714,
-0.04729349911212921,
0.08444632589817047,
-0.004778148606419563,
-0.12503887712955475,
0.047117915004491806,
-0.05650947242975235,
-0.20110994577407837,
-0.06083110347390175,
0.09889473766088486,
0.3026524484157562,
0.16557112336158752,
-0.32814377546310425,
-0.15187916159629822,
0.009949114173650742,
0.06914424151182175,
0.09693003445863724,
-0.03760718181729317,
-0.0499599352478981,
0.2177456170320511,
-0.0484442412853241,
-0.08218435198068619,
-0.041425950825214386,
0.040221620351076126,
0.08662104606628418,
0.06763003766536713,
-0.11590029299259186,
0.05197630822658539,
0.0367596410214901,
0.08960611373186111,
-0.10980061441659927,
0.06173271685838699,
0.08885517716407776,
0.07536538690328598,
-0.06478049606084824,
0.08668021857738495,
0.12807609140872955,
0.11687257140874863,
0.022694218903779984,
0.15040713548660278,
0.02697688154876232,
-0.008581583388149738,
-0.24356690049171448,
-0.008477888070046902,
-0.11916139721870422,
-0.007447121664881706,
0.2593197226524353,
0.14652006328105927,
-0.0053018005564808846,
-0.12191198021173477,
-0.31037697196006775,
-0.10198549181222916,
0.038675613701343536,
0.014304392971098423,
-0.08431997895240784,
0.1749354898929596,
0.10272466391324997,
0.08659062534570694,
0.06348880380392075,
-0.0033870369661599398,
0.06438387185335159,
0.05283580347895622,
-0.20170998573303223,
-0.009461783803999424,
-0.02096026949584484,
0.08204895257949829,
-0.014201507903635502,
0.10717751830816269,
-0.13220900297164917,
0.04164239764213562,
-0.06686269491910934,
-0.10968856513500214,
0.2048289179801941,
-0.21689608693122864,
0.15038850903511047,
0.13623511791229248,
0.0140265803784132,
0.09045582264661789,
0.15937727689743042,
-0.3790554106235504,
-0.05098380520939827,
-0.07522200793027878,
-0.20088189840316772,
0.1450657993555069,
0.014016687870025635,
0.06226508319377899,
0.09230136126279831,
0.00034934142604470253,
-0.08490419387817383,
0.0796421691775322,
-0.012870889157056808,
-0.12858779728412628,
0.12222161144018173,
-0.09239345788955688,
-0.08936657011508942,
-0.01170872151851654,
0.1555967628955841,
0.1777792125940323,
-0.31205934286117554,
0.1777639091014862,
0.037815723568201065,
-0.047146935015916824,
0.17375732958316803,
-0.09136155992746353,
-0.20786738395690918,
-0.048187319189310074,
0.20199403166770935,
0.016798147931694984,
0.09980309754610062,
0.0317683070898056,
0.17689646780490875,
0.10188084095716476,
-0.07302313297986984,
0.17660708725452423,
0.10351407527923584,
0.010763627476990223,
-0.32297709584236145,
-0.07580824941396713,
0.123520627617836,
0.053682953119277954,
0.08696841448545456,
-0.02067411132156849,
-0.02424851432442665,
0.1156141459941864,
-0.02459394931793213,
-0.004947479348629713,
0.010524180717766285,
-0.4574652910232544,
-0.18066580593585968,
0.0688871219754219,
0.1423712968826294,
0.24027703702449799,
0.071551114320755,
0.09578175097703934,
0.043324727565050125,
0.12124373018741608,
-0.09664194285869598,
0.03061370924115181,
-0.05471133813261986,
-0.048923321068286896,
0.24511632323265076,
0.0956713929772377,
0.07282357662916183,
0.06358007341623306,
0.18395107984542847,
0.052967049181461334,
-0.1814369410276413,
0.04854917898774147,
0.004709106869995594,
-0.21038784086704254,
-0.10668257623910904,
-0.02000635303556919,
0.018263518810272217,
-0.03200211003422737,
-0.17015357315540314,
0.07100016623735428,
0.06608168035745621,
-0.12391998618841171,
0.0063672298565506935,
-0.007110913749784231,
0.05120030790567398,
0.01595975086092949,
-0.2546696066856384,
0.13283437490463257,
0.039089735597372055,
0.03203531354665756,
0.14384719729423523,
0.05940007045865059,
0.26707783341407776,
0.08231428265571594,
0.011943574994802475,
0.14777112007141113,
0.07019340246915817,
0.10493765026330948,
-0.12395088374614716,
0.09696949273347855,
0.14766685664653778,
-0.16771666705608368,
0.1384711116552353,
-0.015363408252596855,
-0.07292573899030685,
0.1006336435675621,
0.021538404747843742,
0.1112828329205513,
0.16933542490005493,
0.2612692713737488,
0.21786832809448242,
0.0877375453710556,
0.15590785443782806,
-0.07755032926797867,
0.12214835733175278,
-0.057342108339071274,
0.09624623507261276,
0.08073806017637253,
0.10640276223421097,
-0.13541032373905182,
-0.016752051189541817,
-0.027588071301579475,
-0.1886487454175949,
0.16472357511520386,
0.11757608503103256,
-0.05723636597394943,
-0.15312370657920837,
0.0017279691528528929,
-0.30125296115875244,
-0.035599805414676666,
-0.015140745788812637,
-0.016477251425385475,
-0.020979590713977814,
-0.00787865649908781,
-0.08022544533014297,
0.04653526097536087,
-0.1078936830163002,
-0.09864232689142227,
0.0362088717520237,
-0.030826885253190994,
0.011808203533291817,
0.05926197022199631,
0.05268504470586777,
-0.23557643592357635,
0.022758787497878075,
0.10378829389810562,
-0.032086197286844254,
0.1112845242023468,
-0.11538947373628616,
0.048691410571336746,
0.14068302512168884,
-0.02046741172671318,
0.016432905569672585,
0.023661796003580093,
-0.16652436554431915,
0.29786744713783264,
-0.10438603907823563,
-0.2505725026130676,
-0.07588137686252594,
-0.16252128779888153,
0.027427956461906433,
-0.10682598501443863,
0.0816916972398758,
-0.14712324738502502,
-0.1681911051273346,
0.037469252943992615,
-0.031280651688575745,
-0.08952104300260544,
0.023012913763523102,
-0.06753445416688919,
-0.06543952226638794,
0.13925707340240479,
0.008665633387863636,
0.018122084438800812,
-0.05877353623509407,
0.08760981261730194,
-0.02636152319610119,
-0.3280967175960541,
0.005874934606254101,
0.29966893792152405,
-0.0830051377415657,
-0.1552039384841919,
0.16972596943378448,
-0.021751226857304573,
0.02271367236971855,
-0.03389764204621315,
0.09709597378969193,
0.044500354677438736,
0.0035940343514084816,
-0.009970670565962791,
-0.08436984568834305,
-0.02366027608513832,
0.07719617336988449,
-0.1381009966135025,
-0.0412357822060585,
-0.12587802112102509,
0.20362842082977295,
-0.1096305176615715,
0.04854387044906616,
-0.028621111065149307,
-0.08539748191833496,
-0.14886540174484253,
0.012860177084803581,
-0.03896242380142212,
0.10055465996265411,
0.13612625002861023,
-0.25344792008399963,
0.1469619870185852,
0.12358415871858597,
0.18829593062400818,
0.07816702127456665,
0.006463351659476757,
0.049885764718055725,
-0.19234582781791687,
-0.031364936381578445,
0.1473877876996994,
-0.019150100648403168,
-0.15382882952690125,
-0.09157639741897583,
-0.11206420511007309,
-0.057354483753442764,
0.08955696225166321,
-0.13136205077171326,
-0.1455042064189911,
-0.309893399477005,
-0.04584633931517601,
0.03424936532974243,
0.08848729729652405,
-0.06395283341407776,
-0.10448336601257324,
0.018349068239331245,
-0.04938004910945892,
0.026660185307264328,
-0.015803851187229156,
0.12788936495780945,
-0.03432685509324074,
-0.0830320417881012,
0.03519340604543686,
-0.03932527080178261,
-0.31438368558883667,
-0.18422330915927887,
0.03835636377334595,
-0.05292116850614548,
-0.11542027443647385,
0.07062384486198425,
-0.04439166560769081,
0.16280004382133484,
-0.165823295712471,
-0.0954674482345581,
0.12532000243663788,
0.2909805476665497,
-0.08608764410018921,
0.025584379211068153,
-0.09928657859563828,
0.13723048567771912,
-0.19920223951339722,
0.16248437762260437,
-0.23030737042427063,
0.2208492010831833,
-0.22482846677303314,
-0.04316015914082527,
0.03750772774219513,
0.1384030282497406,
0.19043657183647156,
-0.11648090183734894,
-0.35933059453964233,
-0.1766657531261444,
-0.1440340131521225,
0.14592303335666656,
-0.2917884588241577,
-0.025245293974876404,
-0.09961065649986267,
0.1553828865289688,
0.0004998637014068663,
0.17669294774532318,
-0.006263127084821463,
0.03274097666144371,
-0.034325502812862396,
0.1453211009502411,
0.0031218789517879486,
-0.04650760442018509,
-0.1238895133137703,
0.12768304347991943,
0.008108153939247131,
0.09496274590492249,
0.016864076256752014,
-0.10273856669664383,
0.15846888720989227,
-0.023469001054763794,
-0.047107819467782974,
-0.06922762095928192,
-0.1076507493853569,
-0.10039227455854416,
0.13211843371391296,
0.05360383167862892,
-0.024068962782621384,
-0.16964270174503326,
-0.1210860013961792,
0.12372832745313644,
0.03910355642437935,
-0.1720201075077057,
-0.024676430970430374,
-0.20419292151927948,
0.10957027971744537,
-0.1508963257074356,
0.12225790321826935,
-0.08703616261482239,
0.12829215824604034,
-0.12431646138429642,
-0.2915690541267395,
-0.09959003329277039,
0.010775416158139706,
-0.06991060823202133,
0.02915523387491703,
0.02849813550710678,
-0.04366772249341011,
0.1506175845861435,
-0.12875834107398987,
0.09486708790063858,
0.0908941850066185,
0.1914331167936325,
-0.05733513832092285,
0.07260804623365402,
0.07715796679258347,
0.008501964621245861,
0.02106991410255432,
-0.054213814437389374,
0.031249389052391052,
0.10907429456710815,
0.04268508777022362,
0.11190756410360336,
-0.07453487068414688,
-0.16871316730976105,
0.03513651713728905,
-0.07651983946561813,
0.14476840198040009,
0.01693231426179409,
0.13887467980384827,
0.0680742859840393,
0.09897936880588531,
-0.17678776383399963,
0.21880604326725006,
0.15939262509346008,
-0.3709962069988251,
-0.07114804536104202,
-0.19371150434017181,
-0.008195269852876663,
0.14561450481414795,
0.031201284378767014,
-0.1287798136472702,
0.2821817398071289,
-0.21066634356975555,
0.17172017693519592,
-0.18676289916038513,
0.09603073447942734,
0.1837286502122879,
-0.1089569553732872,
-0.07095038145780563,
0.3641207218170166,
-0.129787877202034,
-0.2678146958351135,
-0.05567057430744171,
-0.04043133929371834,
-0.05342362821102142,
0.0850306823849678,
-0.012531977146863937,
-0.12565457820892334,
-0.12048313021659851,
0.08652906119823456,
-0.10650237649679184,
0.0023511527106165886,
-0.07586890459060669,
-0.355779767036438,
-0.07162551581859589,
-0.17304563522338867,
0.07398691028356552,
0.036101195961236954,
0.14206883311271667,
0.10268035531044006,
0.19863015413284302,
0.055052366107702255,
-0.10482992231845856,
-0.07905511558055878,
0.17938216030597687,
0.014699106104671955,
-0.1286514550447464,
-0.00043066134094260633,
0.07053227722644806,
-0.08685795962810516,
0.05719015374779701,
0.1943443864583969,
-0.17712150514125824,
-0.1537359207868576,
-0.09952469170093536,
-0.21073207259178162,
-0.0529770627617836,
-0.06431897729635239,
0.07897116243839264,
-0.03202769532799721,
-0.09584461897611618,
0.053024549037218094,
0.01411617174744606,
-0.17903240025043488,
-0.029083317145705223,
0.18736888468265533,
-0.10777556151151657,
0.025256095454096794,
0.16441483795642853,
0.0002920390688814223,
-0.1258654147386551,
-0.03458326309919357,
-0.04834841936826706,
0.08360710740089417,
0.03679077699780464,
0.033924177289009094,
0.2626907527446747,
0.0026751866098493338,
0.029468946158885956,
-0.2871733009815216,
-0.2631763815879822,
-0.09349104762077332,
0.132516548037529,
-0.10277482122182846,
-0.08691410720348358,
-0.04534830152988434,
0.1876552402973175,
-0.06446018069982529,
0.23323513567447662,
0.1648973673582077,
0.15432651340961456
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. Immunology consultOtherComplete adherence to regional immunization schedules and influenza vaccination is indicated .Maintain a high index of suspicion for endocrine, immune, and renal problems and address accordingly.Treatment of ManifestationsNeonatal/acute decompensation. Birth, infections, trauma, surgery, postpartum recovery, or other forms of stress and hormonal changes can result in a catabolic response that leads, among other things, to protein breakdown with release of propiogenic amino acids that cannot be metabolized in PA. The goal of acute management is to reverse this process through promotion of anabolism and removal of toxic intermediates. The treatment of individuals with acutely decompensated PA is a medical emergency and requires a transfer to a center with biochemical genetics expertise and the ability to support urgent hemodialysis, especially if hyperammonemia is present.In-patient managementAssess and manage ventilation and circulation as necessary.Treat precipitating factors (fever, infection, dehydration, pain, vomiting, and other sources of stress). | [
-0.08703818917274475,
0.08079160004854202,
-0.1578381359577179,
-0.16651107370853424,
-0.06704480201005936,
0.014701349660754204,
0.06626860797405243,
-0.23588639497756958,
-0.0007211276097223163,
-0.18825878202915192,
0.2213524729013443,
0.04241202771663666,
0.15394587814807892,
0.006693569477647543,
-0.3147536814212799,
0.062059346586465836,
-0.09640499204397202,
-0.19508448243141174,
0.003885583719238639,
-0.009977111592888832,
0.2645539343357086,
-0.2002505213022232,
0.0022366181947290897,
0.08504930883646011,
0.25377699732780457,
0.02180546149611473,
0.1842709183692932,
-0.23040392994880676,
0.06487573683261871,
-0.00633227126672864,
-0.013860871084034443,
0.1253603845834732,
0.031706709414720535,
-0.20433054864406586,
-0.08201002329587936,
-0.1739984005689621,
-0.053424056619405746,
-0.21741549670696259,
0.1945812702178955,
-0.16529136896133423,
0.08922596275806427,
-0.1531057208776474,
0.23632776737213135,
0.042090315371751785,
0.04248088225722313,
-0.05710555240511894,
0.057392340153455734,
-0.04160235449671745,
-0.16756150126457214,
0.2926992177963257,
-0.017127441242337227,
-0.0030130252707749605,
-0.3349136710166931,
-0.1372961550951004,
0.24048835039138794,
-0.17232979834079742,
-0.03315093368291855,
-0.007048037368804216,
-0.1500564068555832,
0.11754704266786575,
0.09580900520086288,
-0.3016852140426636,
-0.11392710357904434,
-0.3831207752227783,
0.1191762238740921,
0.09910520166158676,
-0.06175989285111427,
0.09029220044612885,
0.17146484553813934,
-0.08161669969558716,
0.08401688188314438,
-0.061177317053079605,
-0.03922686353325844,
0.053180910646915436,
0.0009234441095031798,
0.02354332059621811,
0.21015435457229614,
-0.07497315853834152,
-0.06272827833890915,
-0.32662585377693176,
-0.2439213991165161,
0.07288338989019394,
0.006839663255959749,
-0.1138172298669815,
-0.19301778078079224,
-0.013343477621674538,
0.1737058460712433,
-0.0260405782610178,
0.02211187593638897,
0.16425660252571106,
0.09392800182104111,
-0.021355297416448593,
-0.05469921603798866,
0.06258805841207504,
-0.013256745412945747,
-0.23386742174625397,
0.08149068802595139,
-0.010626176372170448,
-0.1439477652311325,
0.18657714128494263,
0.03641582652926445,
0.0967773050069809,
-0.09145519137382507,
-0.03729577362537384,
0.024182859808206558,
0.06039874628186226,
-0.21170206367969513,
-0.048852305859327316,
-0.06136632338166237,
0.004628055728971958,
0.1607540398836136,
-0.13626807928085327,
0.20897921919822693,
0.13986103236675262,
-0.4395604133605957,
-0.08463849872350693,
-0.05512084439396858,
0.25273630023002625,
0.13300752639770508,
-0.06513845920562744,
0.0018928556237369776,
0.2965494990348816,
0.11416615545749664,
0.050551265478134155,
0.07452069967985153,
-0.046393588185310364,
0.06764529645442963,
0.01320410706102848,
0.15123148262500763,
-0.005144735332578421,
0.06143153831362724,
-0.05053824931383133,
0.06503351777791977,
-0.11635908484458923,
0.08353360742330551,
-0.11409836262464523,
-0.31362536549568176,
-0.15455815196037292,
0.0944533720612526,
0.0964658334851265,
0.2744675278663635,
0.29609215259552,
0.15103808045387268,
0.0958210825920105,
0.04486912488937378,
0.05761173740029335,
0.3068614602088928,
0.14427067339420319,
0.16689372062683105,
0.04126012325286865,
0.01617937721312046,
-0.2734396159648895,
0.02753356471657753,
-0.08141756802797318,
0.1123751774430275,
0.18082010746002197,
-0.11333387345075607,
0.26716718077659607,
-0.13521210849285126,
-0.003934998996555805,
0.056587789207696915,
0.05862302705645561,
0.14551135897636414,
0.07827726006507874,
-0.1355569213628769,
0.16009511053562164,
-0.20705880224704742,
0.11265546083450317,
0.014280580915510654,
-0.15119902789592743,
-0.03783123940229416,
0.01882190629839897,
-0.02709406428039074,
0.02686612866818905,
-0.0032357266172766685,
0.026025505736470222,
-0.11230677366256714,
-0.08580078929662704,
-0.01894463784992695,
0.20660802721977234,
0.18660461902618408,
-0.03227663040161133,
-0.1500658392906189,
0.03449832648038864,
0.024341212585568428,
-0.1530551314353943,
0.19009315967559814,
0.15719695389270782,
0.058066919445991516,
0.2617834806442261,
0.24574558436870575,
0.0008030899916775525,
-0.0379675030708313,
0.04552140086889267,
0.13365814089775085,
-0.20031660795211792,
0.16682292520999908,
0.031452376395463943,
0.0494428426027298,
-0.2510862946510315,
-0.055271755903959274,
-0.2862979769706726,
0.09720797836780548,
-0.1216290295124054,
-0.11010769754648209,
-0.037818070501089096,
-0.06109214946627617,
-0.18809200823307037,
0.043564606457948685,
0.045943483710289,
-0.11320262402296066,
0.08064643293619156,
-0.10048064589500427,
-0.15625493228435516,
-0.3052387237548828,
0.005239433608949184,
-0.0836576595902443,
-0.07803868502378464,
-0.10047730803489685,
0.16426295042037964,
-0.20561198890209198,
-0.11686794459819794,
0.1403030902147293,
-0.15980727970600128,
-0.17395450174808502,
-0.0238106157630682,
-0.2576923668384552,
-0.09418981522321701,
0.10597937554121017,
-0.1162378191947937,
-0.18109600245952606,
0.03013891726732254,
0.12615588307380676,
0.18745681643486023,
-0.20161736011505127,
0.007854846306145191,
-0.17297516763210297,
0.26553717255592346,
-0.08333273977041245,
-0.05748279020190239,
-0.4637465476989746,
0.00013165418931748718,
0.1824231743812561,
-0.0634053498506546,
0.037481024861335754,
0.12295186519622803,
0.03940695524215698,
0.061849456280469894,
-0.1341686248779297,
-0.03560858592391014,
-0.07336924970149994,
0.028753865510225296,
-0.009476125240325928,
-0.019950021058321,
-0.3265504837036133,
-0.059999871999025345,
0.14424173533916473,
-0.07105137407779694,
-0.02484135888516903,
-0.09101319313049316,
-0.1619550585746765,
0.03947902098298073,
0.08467741310596466,
0.07664307951927185,
0.20535461604595184,
0.030042359605431557,
-0.16976317763328552,
0.12102575600147247,
0.025232994928956032,
-0.09719448536634445,
-0.037156686186790466,
0.22250083088874817,
0.26650184392929077,
0.1510733962059021,
-0.2812490165233612,
-0.04244374483823776,
-0.016680864617228508,
0.15031114220619202,
0.16673199832439423,
-0.08330598473548889,
-0.07616618275642395,
0.3382759094238281,
0.04142226651310921,
0.039830535650253296,
0.09188049286603928,
0.07926822453737259,
-0.010372422635555267,
0.013615213334560394,
-0.03734724968671799,
-0.03681758791208267,
0.037093743681907654,
0.05131370201706886,
0.023780306801199913,
-0.07291098684072495,
0.15110422670841217,
0.09750179201364517,
-0.11755054444074631,
0.08099214732646942,
0.03656526654958725,
0.012348034419119358,
-0.015784459188580513,
0.15351727604866028,
-0.016237642616033554,
-0.06377077847719193,
-0.30788907408714294,
-0.03566501662135124,
-0.0840119868516922,
0.07820723950862885,
0.09509403258562088,
0.27734801173210144,
0.01982400007545948,
-0.11821271479129791,
-0.3719642460346222,
0.033179931342601776,
-0.07936599850654602,
0.008724057115614414,
-0.1199253648519516,
0.24818605184555054,
0.06610380858182907,
0.1479303389787674,
0.04769410938024521,
0.07398398220539093,
0.10026881098747253,
-0.11680511385202408,
-0.0898066833615303,
-0.05931851640343666,
0.08328910917043686,
-0.0021382691338658333,
0.0028713499195873737,
0.04141237586736679,
0.02983327955007553,
0.06772633641958237,
-0.04125114530324936,
-0.0989285334944725,
0.1967020481824875,
-0.19951747357845306,
0.2463902235031128,
0.02709602750837803,
-0.05367322266101837,
0.07403901219367981,
0.09410401433706284,
-0.3427843451499939,
0.06820492446422577,
-0.2277148962020874,
-0.14467264711856842,
-0.006995872128754854,
-0.005779959261417389,
0.07299315184354782,
0.11906605958938599,
-0.01784485951066017,
-0.08112654089927673,
0.032384708523750305,
-0.004828684963285923,
-0.20308257639408112,
0.2702174782752991,
-0.05611112713813782,
-0.07658754289150238,
0.15895195305347443,
0.055527977645397186,
0.1343662291765213,
-0.18660013377666473,
0.10681803524494171,
0.20489196479320526,
-0.12123513221740723,
-0.0006439112476073205,
-0.0728289783000946,
-0.06553604453802109,
-0.15608084201812744,
0.18829011917114258,
-0.015573378652334213,
0.012591272592544556,
0.17514218389987946,
0.1577261984348297,
0.06285325437784195,
-0.1668320596218109,
0.06563423573970795,
0.10192986577749252,
-0.012506876140832901,
-0.23423831164836884,
-0.13992910087108612,
0.011244433000683784,
-0.10075138509273529,
0.16945746541023254,
-0.02296474389731884,
0.06830069422721863,
0.0889202207326889,
-0.14077262580394745,
0.20192420482635498,
0.052470508962869644,
-0.5151656866073608,
0.039729081094264984,
0.15295392274856567,
-0.0009190423297695816,
0.13827617466449738,
0.07966902107000351,
0.22405444085597992,
0.034515608102083206,
0.10255547612905502,
-0.16300499439239502,
0.09313515573740005,
-0.0301210917532444,
-0.04709748551249504,
0.17056113481521606,
0.21865156292915344,
0.13306882977485657,
-0.033611148595809937,
0.04436847195029259,
0.04165907949209213,
0.005000414326786995,
0.11362957209348679,
-0.04291429743170738,
-0.045346133410930634,
0.03054569475352764,
-0.037413340061903,
0.013006352819502354,
-0.08871734142303467,
-0.20932094752788544,
0.15389275550842285,
0.10545562952756882,
-0.04717693105340004,
-0.04139365628361702,
0.027319202199578285,
0.029949704185128212,
-0.1382446140050888,
-0.17271669209003448,
0.1382749080657959,
0.009577145799994469,
0.00507322745397687,
0.14798055589199066,
0.2003869265317917,
0.30482715368270874,
0.18384148180484772,
-0.08932312577962875,
0.037519421428442,
0.08531762659549713,
0.06294663995504379,
-0.22366267442703247,
0.25096970796585083,
-0.0042559499852359295,
-0.06745374202728271,
0.16967326402664185,
0.0461290180683136,
-0.07919149845838547,
0.14459480345249176,
-0.03872211277484894,
0.17262619733810425,
0.06966975331306458,
0.43678146600723267,
0.14073441922664642,
0.1228206530213356,
0.10764903575181961,
-0.016150420531630516,
-0.038017068058252335,
-0.00409473292529583,
0.1405092179775238,
0.013191528618335724,
-0.0463065542280674,
-0.007120639551430941,
0.1486755907535553,
-0.012217521667480469,
-0.17333835363388062,
0.20911017060279846,
0.20881839096546173,
-0.03296767920255661,
-0.2753709554672241,
-0.016158459708094597,
-0.2328892946243286,
0.00950346514582634,
-0.018820976838469505,
-0.009523925371468067,
0.028991667553782463,
-0.01418528612703085,
-0.004198775161057711,
0.07226700335741043,
-0.04874381795525551,
0.02277776226401329,
-0.015812383964657784,
-0.131426602602005,
-0.06999713182449341,
0.2788877785205841,
0.0417775958776474,
-0.2387944459915161,
-0.0342223085463047,
-0.1490890085697174,
-0.07439868897199631,
0.022358791902661324,
-0.14602750539779663,
0.01110673788934946,
0.19186930358409882,
0.03920113295316696,
-0.05695119500160217,
0.0758945643901825,
-0.09324577450752258,
0.43496447801589966,
-0.10087217390537262,
-0.16535505652427673,
-0.019137896597385406,
-0.2577374279499054,
0.10618609189987183,
-0.058557409793138504,
-0.00849122367799282,
0.008037567138671875,
-0.13969549536705017,
0.14917434751987457,
-0.00794896949082613,
0.015166839584708214,
0.0022025613579899073,
-0.0795600563287735,
0.00939351785928011,
0.2405657023191452,
0.0033566399943083525,
0.08025005459785461,
-0.1572144329547882,
0.09495285898447037,
0.0032140607945621014,
-0.19772174954414368,
-0.018967902287840843,
0.2524791955947876,
0.005168761592358351,
-0.19317284226417542,
0.18706314265727997,
0.02052541822195053,
0.03159208595752716,
0.11465908586978912,
0.15011031925678253,
-0.03604745492339134,
0.07689736038446426,
0.06739036738872528,
-0.0895603746175766,
-0.03508738428354263,
0.05504878982901573,
-0.16902656853199005,
-0.01546552125364542,
-0.12724195420742035,
0.18903380632400513,
0.04850814491510391,
-0.03952636197209358,
-0.063685342669487,
-0.14165911078453064,
-0.11087701469659805,
0.07192575931549072,
-0.1651315987110138,
0.13660815358161926,
0.15332786738872528,
-0.3372052013874054,
0.26471149921417236,
0.15753108263015747,
0.1550750732421875,
-0.030810905620455742,
0.005253724753856659,
-0.011236337013542652,
-0.11957728117704391,
0.010255739092826843,
0.06485363841056824,
-0.12243400514125824,
-0.09074683487415314,
-0.02237734943628311,
-0.11006778478622437,
-0.12461031228303909,
0.02298671565949917,
-0.18879356980323792,
-0.1339263767004013,
-0.2044406682252884,
0.02930871956050396,
0.06750877946615219,
0.07405047863721848,
0.013838349841535091,
-0.08072022348642349,
0.005900824908167124,
-0.09432545304298401,
0.07095661014318466,
-0.017845164984464645,
0.053561318665742874,
-0.13049376010894775,
-0.10506582260131836,
0.012087255716323853,
-0.15456518530845642,
-0.284364253282547,
-0.21883618831634521,
0.1029348149895668,
-0.02544700913131237,
-0.28838998079299927,
0.021644195541739464,
0.055277254432439804,
-0.03637228161096573,
-0.210995614528656,
-0.07717883586883545,
0.07903505861759186,
0.26506295800209045,
0.08258725702762604,
-0.03633352369070053,
-0.26146388053894043,
0.17093691229820251,
-0.2196425050497055,
0.09510920941829681,
-0.2525463402271271,
0.27096283435821533,
-0.26376691460609436,
-0.043037593364715576,
0.04666919633746147,
0.24067270755767822,
0.13961836695671082,
-0.07268049567937851,
-0.4172254502773285,
-0.2239101529121399,
-0.13283555209636688,
0.07311909645795822,
-0.306761771440506,
-0.056732360273599625,
0.035341378301382065,
0.14433084428310394,
0.13302236795425415,
0.05984789878129959,
0.029045909643173218,
-0.02350786328315735,
-0.011255571618676186,
0.18866640329360962,
-0.2307710200548172,
0.0004005410592071712,
-0.06444959342479706,
0.2826305329799652,
-0.011630627326667309,
0.1662352979183197,
0.045082271099090576,
-0.11551256477832794,
0.012308124452829361,
-0.09943218529224396,
0.010898925364017487,
-0.0761176124215126,
-0.05114474520087242,
0.012539844959974289,
0.049336161464452744,
0.11264286190271378,
0.02143101394176483,
-0.1497996747493744,
-0.04657397419214249,
0.09506375342607498,
-0.011837614700198174,
-0.3167817294597626,
0.0916370302438736,
-0.1534026712179184,
0.11392513662576675,
-0.013661087490618229,
0.15909318625926971,
-0.21123935282230377,
0.2842525541782379,
-0.11842509359121323,
-0.18414747714996338,
0.03341647982597351,
-0.10106943547725677,
0.059148915112018585,
0.05009697377681732,
0.06894980370998383,
0.07170149683952332,
0.2215675264596939,
-0.1721421331167221,
0.08767819404602051,
-0.16752390563488007,
0.16566486656665802,
-0.2247149646282196,
0.07471355050802231,
0.06990574300289154,
-0.007371784653514624,
-0.061344001442193985,
-0.022722074761986732,
0.08503054827451706,
0.16614609956741333,
-0.107142373919487,
0.07008874416351318,
-0.02840878628194332,
-0.12104380875825882,
0.07138753682374954,
0.012152225710451603,
0.02946184203028679,
0.05725765600800514,
-0.040339041501283646,
-0.014876529574394226,
0.22755646705627441,
-0.16772738099098206,
0.3778156340122223,
0.0856526792049408,
-0.29939723014831543,
-0.1785324066877365,
-0.1594024896621704,
0.11269314587116241,
0.04720534011721611,
-0.028922172263264656,
-0.0697457492351532,
0.35745248198509216,
-0.33294543623924255,
0.036475054919719696,
-0.23164962232112885,
0.15544205904006958,
0.0733800083398819,
-0.08164282143115997,
-0.05388002470135689,
0.39851808547973633,
-0.056972403079271317,
-0.27918630838394165,
-0.17608344554901123,
-0.024420922622084618,
0.011798582971096039,
0.05756410211324692,
0.12652119994163513,
-0.14048297703266144,
-0.12724560499191284,
0.16854852437973022,
-0.15473723411560059,
0.12925976514816284,
-0.25157004594802856,
-0.24401286244392395,
-0.10968785732984543,
-0.15106119215488434,
0.1057136133313179,
-0.1526724398136139,
0.1613004058599472,
-0.07434800267219543,
0.1467742919921875,
0.08082591742277145,
-0.10303306579589844,
-0.03478049114346504,
0.0937977060675621,
-0.010652286931872368,
-0.09478537738323212,
0.04677893966436386,
0.09356459975242615,
-0.03759479895234108,
0.14890778064727783,
0.04225461557507515,
-0.17251059412956238,
-0.23159141838550568,
-0.13743944466114044,
-0.37963759899139404,
0.04767781123518944,
-0.03982992097735405,
0.09222634881734848,
-0.00227655959315598,
-0.1705680936574936,
0.0038809743709862232,
-0.07137738913297653,
-0.0625028982758522,
0.09568984806537628,
0.09695568680763245,
-0.04496747627854347,
-0.03712444752454758,
0.09837059676647186,
0.00304715265519917,
-0.0627865269780159,
-0.22473812103271484,
-0.19137319922447205,
0.11267655342817307,
0.03732134401798248,
-0.16425830125808716,
0.15434491634368896,
-0.020304478704929352,
-0.030380653217434883,
-0.17373216152191162,
-0.24564701318740845,
-0.003771926974877715,
0.05830040201544762,
-0.1597374528646469,
-0.07366121560335159,
-0.04278019070625305,
0.011530870571732521,
0.05878964811563492,
0.20505304634571075,
0.1138777881860733,
0.1434289664030075
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. in PA. The goal of acute management is to reverse this process through promotion of anabolism and removal of toxic intermediates. The treatment of individuals with acutely decompensated PA is a medical emergency and requires a transfer to a center with biochemical genetics expertise and the ability to support urgent hemodialysis, especially if hyperammonemia is present.In-patient managementAssess and manage ventilation and circulation as necessary.Treat precipitating factors (fever, infection, dehydration, pain, vomiting, and other sources of stress).Determine the need for sepsis workup and antibiotics.Reverse catabolism by giving intravenous glucose and lipids.The volume, glucose content and electrolyte composition of intravenous fluids is determined by age, target glucose infusion rate, cardiovascular status, renal condition, and co-administration of other medications.Intravenous D10 ½ normal saline typically between 100% and 150% of the maintenance requirements is a common starting fluid. Dextrose solutions exceeding the concentration of 12.5% require a central line placement. The target | [
-0.16374200582504272,
0.16873784363269806,
-0.13251467049121857,
-0.2939031720161438,
-0.03368906304240227,
-0.01833771914243698,
0.1733386069536209,
-0.3998052179813385,
-0.034323982894420624,
-0.1494520604610443,
0.13030464947223663,
-0.08062973618507385,
0.06379759311676025,
0.03496160730719566,
-0.10232491791248322,
-0.11426407843828201,
-0.06738719344139099,
0.041436079889535904,
-0.13694827258586884,
-0.028082748875021935,
0.2967104911804199,
0.013039672747254372,
0.03667791932821274,
0.24662736058235168,
0.12590815126895905,
0.02566746436059475,
0.1104186549782753,
-0.22207199037075043,
0.3122950792312622,
0.23099678754806519,
-0.21033743023872375,
0.0033504213206470013,
0.0016019243048503995,
-0.33061131834983826,
-0.0057726409286260605,
-0.18139968812465668,
-0.07263550162315369,
-0.09475588798522949,
0.14103694260120392,
0.02024935930967331,
-0.11912506073713303,
-0.1083112582564354,
0.14729106426239014,
0.0023380571510642767,
0.2095164805650711,
-0.1153075322508812,
-0.01385402213782072,
-0.10744427144527435,
-0.07012297958135605,
0.23632977902889252,
0.11063215136528015,
-0.15707524120807648,
-0.29217201471328735,
-0.09051588922739029,
0.29448843002319336,
-0.1505226343870163,
-0.07005372643470764,
0.29160621762275696,
-0.09610240161418915,
0.046471621841192245,
0.13147889077663422,
-0.2764410078525543,
0.000745754165109247,
-0.32938703894615173,
0.16288764774799347,
-0.05536594241857529,
-0.14999689161777496,
0.2559812068939209,
0.2525867819786072,
-0.24368874728679657,
0.15190182626247406,
-0.006960505153983831,
0.02107219770550728,
0.12103701382875443,
0.10658535361289978,
-0.023684807121753693,
0.255304753780365,
0.03725353255867958,
-0.05197153240442276,
-0.2919158637523651,
-0.12932665646076202,
-0.0558609701693058,
-0.07664062082767487,
-0.1252594143152237,
-0.10085611790418625,
-0.03377717733383179,
0.12409864366054535,
0.1629221886396408,
-0.04070550575852394,
0.05507223680615425,
0.15036070346832275,
-0.04330979660153389,
-0.02169308066368103,
0.09807370603084564,
-0.009612852707505226,
-0.032095927745103836,
-0.08565539121627808,
-0.25174474716186523,
-0.06723831593990326,
0.324022114276886,
0.20188108086585999,
-0.05340377613902092,
-0.12192858010530472,
-0.1617639660835266,
0.0057686627842485905,
0.015148190781474113,
-0.09703414887189865,
0.267428994178772,
-0.16452042758464813,
0.036849141120910645,
0.09750083833932877,
-0.09130769222974777,
0.06975928694009781,
0.08586602658033371,
-0.34603050351142883,
-0.11543980240821838,
0.12544696033000946,
0.16027036309242249,
0.12556689977645874,
-0.1766771674156189,
-0.07399590313434601,
0.13935980200767517,
0.10679782927036285,
0.013812833465635777,
0.034658584743738174,
-0.0030711733270436525,
0.1834230124950409,
-0.012021669186651707,
0.2504109740257263,
-0.27523791790008545,
-0.003488351823762059,
-0.1115526631474495,
0.1440669745206833,
-0.03678038716316223,
0.09903042018413544,
-0.023721057921648026,
-0.22426548600196838,
-0.20666204392910004,
0.15710648894309998,
0.08267921954393387,
0.26261913776397705,
0.32266855239868164,
0.0692422091960907,
0.10028394311666489,
-0.09618303924798965,
-0.043700091540813446,
0.375138521194458,
-0.07287247478961945,
-0.10129894316196442,
0.01836228556931019,
-0.035670675337314606,
-0.2726779282093048,
-0.02042744867503643,
-0.042977847158908844,
-0.0007599100354127586,
0.3494958281517029,
-0.024310842156410217,
0.28858137130737305,
-0.1294994354248047,
-0.14655359089374542,
0.1265910565853119,
0.06078973412513733,
0.046845026314258575,
0.07604975998401642,
-0.10705182701349258,
0.01656286232173443,
-0.07174348831176758,
0.1523333489894867,
-0.056168653070926666,
-0.16500678658485413,
-0.06386017054319382,
-0.08068777620792389,
0.0036387527361512184,
0.03157655894756317,
-0.17377139627933502,
-0.044690750539302826,
-0.11413513869047165,
-0.03166345879435539,
0.05033845454454422,
0.03784256801009178,
0.07382263988256454,
-0.1740492582321167,
-0.2792510688304901,
0.04572543874382973,
0.04381800815463066,
-0.1742992103099823,
0.34820273518562317,
0.1180715411901474,
0.10359062999486923,
0.2568010687828064,
0.3176625370979309,
0.06660885363817215,
-0.32455477118492126,
-0.10785619169473648,
-0.07775167375802994,
-0.040971819311380386,
0.28757545351982117,
0.023574957624077797,
-0.035404760390520096,
-0.02381928265094757,
0.08760318160057068,
-0.3382958769798279,
0.040298137813806534,
0.019422173500061035,
-0.2835380434989929,
0.09514567255973816,
0.020581934601068497,
0.005278183147311211,
0.003918892238289118,
-0.07566314935684204,
-0.22882477939128876,
0.11958371102809906,
-0.06773601472377777,
-0.08419550955295563,
-0.2694946229457855,
-0.0063121747225522995,
0.09714780002832413,
-0.16677270829677582,
0.08732166886329651,
0.2416057288646698,
-0.20299486815929413,
-0.01981671340763569,
0.08225029706954956,
-0.18935367465019226,
-0.22663423418998718,
0.05658477172255516,
-0.20531679689884186,
-0.1859726905822754,
-0.010211234912276268,
-0.05721519887447357,
-0.18970976769924164,
-0.01303107850253582,
0.2139442414045334,
0.20528148114681244,
-0.32490620017051697,
0.1283404380083084,
-0.24654830992221832,
0.14501912891864777,
-0.16602002084255219,
-0.046082187443971634,
-0.4045095443725586,
0.04749443754553795,
0.08539734035730362,
0.09602409601211548,
0.11863680183887482,
0.12861521542072296,
0.14427685737609863,
-0.12491249293088913,
-0.06117889657616615,
-0.16486012935638428,
0.021560199558734894,
0.005229827016592026,
-0.021595224738121033,
0.24048735201358795,
-0.24536354839801788,
0.12813042104244232,
-0.00789547897875309,
-0.21691617369651794,
-0.20851385593414307,
0.1289827674627304,
-0.3141144812107086,
0.048201270401477814,
0.09380628913640976,
0.02093958482146263,
0.1581902951002121,
-0.11326826363801956,
-0.18530482053756714,
0.054916251450777054,
-0.000525789160747081,
-0.1819889098405838,
-0.029855677857995033,
0.21614289283752441,
0.21400216221809387,
-0.04659102112054825,
-0.1824028640985489,
-0.12369725108146667,
-0.0027002785354852676,
0.18794111907482147,
0.27210262417793274,
-0.4216933250427246,
-0.10720491409301758,
0.08859097212553024,
0.07010941952466965,
-0.17194098234176636,
-0.04097456857562065,
-0.07278189063072205,
-0.02120025083422661,
0.20265232026576996,
0.08335922658443451,
-0.03620636463165283,
0.08071830868721008,
-0.05049226060509682,
-0.02001570723950863,
-0.10854877531528473,
0.21640315651893616,
0.19023112952709198,
-0.007415040861815214,
0.035020358860492706,
0.14303606748580933,
0.25182509422302246,
0.05238921195268631,
0.12335339188575745,
0.027194850146770477,
-0.025383615866303444,
-0.1900356113910675,
-0.029300371184945107,
-0.07925541698932648,
-0.08054733276367188,
0.20128558576107025,
0.2384578138589859,
0.004153134301304817,
-0.2854982912540436,
-0.1817930042743683,
-0.14318105578422546,
0.008216979913413525,
0.007444051094353199,
0.02360614575445652,
0.4059968888759613,
0.019613485783338547,
0.13854077458381653,
0.2091783732175827,
0.09856350719928741,
0.038354236632585526,
0.15639254450798035,
-0.15065093338489532,
-0.10377871990203857,
0.007895458489656448,
-0.09101564437150955,
-0.16870993375778198,
0.08022342622280121,
-0.13514336943626404,
0.03819945082068443,
-0.01907370053231716,
-0.12453186511993408,
0.20012187957763672,
-0.13207267224788666,
0.06229002773761749,
0.09748440235853195,
-0.0655779168009758,
-0.03186749666929245,
0.15292060375213623,
-0.5360978245735168,
0.007625451777130365,
-0.21096792817115784,
-0.027203412726521492,
-0.012337347492575645,
0.01961773820221424,
-0.0676283985376358,
0.18269102275371552,
-0.12421717494726181,
-0.25205889344215393,
-0.05405250936746597,
-0.11890678852796555,
-0.23974844813346863,
-0.06229289248585701,
0.06389740854501724,
-0.16240833699703217,
0.1422872543334961,
0.07925279438495636,
-0.08485336601734161,
-0.15620194375514984,
-0.048561595380306244,
0.21332599222660065,
-0.06753992289304733,
-0.051128990948200226,
0.017980901524424553,
0.016210215166211128,
-0.011785119771957397,
0.1711931973695755,
-0.13287585973739624,
0.18519842624664307,
0.09664919972419739,
0.04940171167254448,
-0.04977036267518997,
-0.15335483849048615,
0.04935252293944359,
-0.06045864149928093,
0.07822137326002121,
-0.13633497059345245,
-0.07290541380643845,
0.03824819251894951,
0.012186795473098755,
0.006391463801264763,
-0.02126634307205677,
0.14310573041439056,
-0.19560106098651886,
-0.0885445773601532,
0.14342476427555084,
0.16187572479248047,
-0.47026926279067993,
-0.12755432724952698,
0.23618566989898682,
0.2431851327419281,
0.2637299597263336,
0.08377004414796829,
0.05384555459022522,
-0.12573908269405365,
0.2766813635826111,
-0.15649528801441193,
0.1260291337966919,
-0.03179914504289627,
-0.0964730754494667,
0.12388641387224197,
0.23575034737586975,
0.05847509577870369,
-0.20473992824554443,
-0.05022485554218292,
0.17033179104328156,
0.04676208272576332,
0.045438412576913834,
-0.01338509377092123,
0.06026161089539528,
0.0016222975682467222,
-0.07862523943185806,
-0.1135740652680397,
-0.18221116065979004,
-0.11651555448770523,
0.19030460715293884,
0.052663978189229965,
0.0074516767635941505,
0.1789652556180954,
0.025465412065386772,
0.10035236924886703,
-0.0528445728123188,
-0.1142100989818573,
0.06208273023366928,
0.12373741716146469,
-0.030203696340322495,
0.14772199094295502,
0.07543715089559555,
0.3851877450942993,
0.10664499551057816,
0.0444764569401741,
0.03127492219209671,
-0.015529531985521317,
-0.10576877743005753,
-0.09472943097352982,
0.0069246902130544186,
-0.020963003858923912,
-0.019779274240136147,
0.08483925461769104,
0.013746986165642738,
-0.249155193567276,
0.15777769684791565,
-0.12512604892253876,
0.09940804541110992,
0.019579356536269188,
0.23804910480976105,
-0.025162523612380028,
-0.06067636236548424,
0.019915761426091194,
-0.05560334026813507,
0.04088512808084488,
0.05069225654006004,
0.2426869422197342,
-0.018618568778038025,
0.013000964187085629,
0.01764594204723835,
0.19501535594463348,
0.0108125489205122,
-0.053493667393922806,
0.0545884370803833,
0.09979093074798584,
-0.023300325497984886,
-0.10728252679109573,
0.003526431741192937,
-0.19584950804710388,
-0.04107020050287247,
0.011690745130181313,
-0.04319693148136139,
0.0459306575357914,
0.03368502855300903,
-0.18207862973213196,
0.042803216725587845,
0.0683821514248848,
0.08866941928863525,
0.04261353984475136,
-0.05968942120671272,
-0.06736385077238083,
0.23462681472301483,
-0.03252807632088661,
-0.08182644098997116,
-0.228646919131279,
-0.06592485308647156,
-0.24784055352210999,
0.11248478293418884,
-0.0433318130671978,
-0.011280524544417858,
0.3258005678653717,
-0.19000829756259918,
-0.01954641565680504,
-0.18208284676074982,
-0.21826300024986267,
0.22992075979709625,
-0.061892785131931305,
-0.13928303122520447,
-0.16570189595222473,
-0.1847635954618454,
-0.07096761465072632,
-0.05047322437167168,
-0.08208153396844864,
0.024171963334083557,
-0.15592771768569946,
0.001971091143786907,
0.05741501599550247,
-0.18894724547863007,
0.07346512377262115,
-0.013770651072263718,
0.21912503242492676,
0.12602971494197845,
-0.20502297580242157,
0.13125841319561005,
-0.21236760914325714,
0.20952196419239044,
0.110066257417202,
-0.16516496241092682,
-0.1838061660528183,
0.19222517311573029,
-0.006646945606917143,
-0.05589855834841728,
0.05903036147356033,
-0.07736349105834961,
-0.009957386180758476,
0.0847393348813057,
0.035933688282966614,
0.054906249046325684,
-0.11549615859985352,
0.031135208904743195,
-0.15909186005592346,
-0.03265148028731346,
0.06410399824380875,
-0.19389483332633972,
-0.04410386085510254,
-0.028138089925050735,
0.1449076533317566,
0.050413038581609726,
-0.24376249313354492,
-0.10663337260484695,
0.061850059777498245,
-0.12082730978727341,
0.1611415594816208,
-0.14741475880146027,
0.007673951331526041,
0.20017004013061523,
-0.3243025541305542,
0.11121156066656113,
0.05106853321194649,
0.041544560343027115,
0.09724487364292145,
0.02635253593325615,
0.004361766390502453,
-0.21048712730407715,
0.0260593481361866,
0.2106996476650238,
0.04720824956893921,
-0.21037596464157104,
-0.03841453790664673,
-0.15190692245960236,
-0.14078553020954132,
0.0052734012715518475,
0.023853737860918045,
-0.14820484817028046,
-0.15544329583644867,
-0.1277589648962021,
-0.18310271203517914,
0.08994901180267334,
0.01089446060359478,
-0.24565359950065613,
-0.08848495036363602,
-0.19527842104434967,
-0.0655326172709465,
-0.05735114961862564,
0.11810612678527832,
-0.09470251947641373,
-0.13428524136543274,
0.16112902760505676,
-0.17676569521427155,
-0.26906225085258484,
-0.3714640736579895,
0.1348281055688858,
0.08268226683139801,
-0.19999466836452484,
-0.054633576422929764,
0.0738518163561821,
0.15118739008903503,
-0.10681890696287155,
0.10682380199432373,
0.11841040104627609,
0.36629053950309753,
-0.032442573457956314,
0.029741879552602768,
-0.054011642932891846,
-0.055926352739334106,
-0.09961677342653275,
0.10637623071670532,
-0.1250436007976532,
0.29648682475090027,
-0.18186987936496735,
0.05900321155786514,
0.07607150077819824,
0.10021840035915375,
0.018447870388627052,
-0.07629191130399704,
-0.25089532136917114,
-0.31550294160842896,
-0.31125715374946594,
0.20602715015411377,
-0.19755250215530396,
-0.09361348301172256,
-0.158537819981575,
0.13356420397758484,
-0.13832814991474152,
0.06808390468358994,
-0.1256609559059143,
-0.11129554361104965,
-0.0014752232236787677,
0.23432040214538574,
-0.11790966987609863,
0.012154161930084229,
0.03903116285800934,
0.2823692858219147,
0.018115639686584473,
0.23888419568538666,
0.0969337522983551,
-0.12238755822181702,
0.053601838648319244,
-0.12623851001262665,
-0.0029180569108575583,
-0.025779761373996735,
-0.11935676634311676,
0.19765278697013855,
0.16054032742977142,
0.034466344863176346,
-0.12116913497447968,
-0.13834600150585175,
-0.13253526389598846,
0.10063522309064865,
0.11358213424682617,
-0.17948800325393677,
0.07254569232463837,
-0.15941204130649567,
0.12524791061878204,
0.23021936416625977,
0.10095565021038055,
-0.18317358195781708,
0.2759343087673187,
-0.04358968883752823,
-0.033061642199754715,
-0.02750531956553459,
-0.2740274965763092,
0.022325655445456505,
0.07576180249452591,
-0.009788206778466702,
0.03594515845179558,
0.2563236653804779,
-0.21383419632911682,
-0.034758757799863815,
-0.1936381459236145,
0.006096835248172283,
-0.06203870847821236,
0.05829168111085892,
-0.12520451843738556,
-0.03866381570696831,
-0.16145317256450653,
-0.0838070884346962,
0.1698574721813202,
0.16948994994163513,
-0.1664850264787674,
0.11787211149930954,
-0.2194320112466812,
0.012373772449791431,
0.06272219121456146,
0.0872369334101677,
0.14467233419418335,
0.010055779479444027,
0.16171526908874512,
-0.06313998252153397,
0.08643312752246857,
-0.10552605241537094,
0.17359744012355804,
0.04431603476405144,
-0.3402038514614105,
-0.2611972391605377,
-0.12733064591884613,
0.17046110332012177,
-0.05229554697871208,
0.1022525429725647,
0.03848294913768768,
0.06868995726108551,
-0.2337096929550171,
0.20392900705337524,
-0.08051682263612747,
-0.004350132774561644,
0.05376775562763214,
-0.12271659821271896,
0.03384178876876831,
0.2865854799747467,
-0.0018335215281695127,
-0.3608477711677551,
-0.0889771580696106,
0.059477679431438446,
-0.0779828280210495,
0.025312913581728935,
0.0983680710196495,
0.10734730213880539,
-0.06471012532711029,
0.17156074941158295,
-0.11260043829679489,
0.08356352895498276,
-0.28673821687698364,
-0.1290234625339508,
-0.015883347019553185,
-0.2856821119785309,
0.1076289489865303,
-0.03749736398458481,
0.16123159229755402,
-0.08440161496400833,
0.26268288493156433,
-0.043037354946136475,
-0.12995310127735138,
-0.021700860932469368,
0.0333106592297554,
-0.012986741028726101,
-0.2171805500984192,
0.20222589373588562,
0.09002020210027695,
-0.09073403477668762,
0.12355631589889526,
0.13110467791557312,
-0.22820506989955902,
-0.12531276047229767,
-0.1808757334947586,
-0.18002158403396606,
-0.021505488082766533,
0.00223101326264441,
0.05712742358446121,
-0.21703383326530457,
0.014126412570476532,
0.061843883246183395,
-0.15204280614852905,
-0.11115533113479614,
-0.13487094640731812,
0.08613266795873642,
-0.003078928915783763,
-0.07231315970420837,
-0.02128802239894867,
-0.07023918628692627,
-0.11409267038106918,
-0.11347217857837677,
-0.09630316495895386,
0.16938766837120056,
-0.06298834830522537,
-0.09591006487607956,
0.20297594368457794,
-0.04906778782606125,
-0.07984437048435211,
-0.07772868126630783,
-0.06827332824468613,
-0.06726694107055664,
0.027186615392565727,
-0.14920464158058167,
-0.2174803763628006,
-0.03256826475262642,
0.22025999426841736,
0.04547132924199104,
0.15893660485744476,
0.04570319131016731,
0.35084569454193115
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. other sources of stress).Determine the need for sepsis workup and antibiotics.Reverse catabolism by giving intravenous glucose and lipids.The volume, glucose content and electrolyte composition of intravenous fluids is determined by age, target glucose infusion rate, cardiovascular status, renal condition, and co-administration of other medications.Intravenous D10 ½ normal saline typically between 100% and 150% of the maintenance requirements is a common starting fluid. Dextrose solutions exceeding the concentration of 12.5% require a central line placement. The target glucose infusion rates varies by age .Additional calories can be provided using parenteral lipid emulsion.The use of intravenous insulin drip may be needed to maintain euglycemia and promote anabolism.Manage protein intake to reduce propiogenic precursors; avoidance of protein transiently for <24-36 hours may be required.Transition to enteral feedings should be commenced as soon as they are tolerated (see Prevention of Primary Manifestations, Dietary management).If transition to enteral feeding | [
-0.07900190353393555,
0.12654855847358704,
-0.1172223910689354,
-0.2719765901565552,
-0.10159432888031006,
0.008095115423202515,
0.18030227720737457,
-0.40248537063598633,
-0.05903397127985954,
-0.08641811460256577,
0.12421800196170807,
-0.14971967041492462,
0.05493755638599396,
0.029264841228723526,
-0.17427192628383636,
-0.1085917130112648,
-0.07107354700565338,
0.09634638577699661,
-0.16452321410179138,
-0.059213634580373764,
0.3254888355731964,
0.0002757269539870322,
0.010784752666950226,
0.23041513562202454,
0.05369448661804199,
-0.01076714601367712,
0.13298147916793823,
-0.22829072177410126,
0.34180229902267456,
0.1961134672164917,
-0.16678103804588318,
0.046243585646152496,
0.03548341989517212,
-0.3185802400112152,
0.018740886822342873,
-0.21658389270305634,
-0.038028642535209656,
-0.10051428526639938,
0.11803751438856125,
0.02074095420539379,
-0.06849239021539688,
-0.08553962409496307,
0.08231323212385178,
-0.010948412120342255,
0.20432619750499725,
-0.08214546740055084,
-0.015371394343674183,
-0.08768460899591446,
-0.050110213458538055,
0.25312313437461853,
0.16575032472610474,
-0.17382243275642395,
-0.2918117046356201,
-0.03230474516749382,
0.31695297360420227,
-0.18262238800525665,
-0.03701996058225632,
0.2602522373199463,
-0.11302495747804642,
-0.010984889231622219,
0.12625068426132202,
-0.3047109842300415,
-0.04982295632362366,
-0.34356725215911865,
0.1600026786327362,
-0.09700711071491241,
-0.11014536023139954,
0.29748669266700745,
0.2679356634616852,
-0.2523077130317688,
0.1807427853345871,
-0.04094315692782402,
0.006283407565206289,
0.14479555189609528,
0.0792739987373352,
-0.06313830614089966,
0.2436218410730362,
0.05052745342254639,
0.026597516611218452,
-0.3029537796974182,
-0.07196302711963654,
-0.0008909789030440152,
-0.07785933464765549,
-0.14879602193832397,
-0.09551043808460236,
0.015382621437311172,
0.19440649449825287,
0.1564258188009262,
-0.13945096731185913,
0.06033388152718544,
0.10425294190645218,
-0.04411287233233452,
0.00714406743645668,
0.08164907246828079,
0.04357420653104782,
-0.058322276920080185,
-0.06322982907295227,
-0.1845519244670868,
-0.1216927170753479,
0.29011353850364685,
0.1728825718164444,
-0.07451941072940826,
-0.1366681307554245,
-0.17528563737869263,
-0.020174197852611542,
0.07952727377414703,
-0.11627952754497528,
0.30756664276123047,
-0.1420351266860962,
-0.0044790045358240604,
0.015332496725022793,
-0.15667442977428436,
0.04023654758930206,
0.09750984609127045,
-0.36164432764053345,
-0.14864934980869293,
0.15008015930652618,
0.1440286636352539,
0.17707954347133636,
-0.12970761954784393,
-0.12810878455638885,
0.09777460247278214,
0.10476301610469818,
0.03812248632311821,
0.01765536516904831,
0.022226985543966293,
0.169012650847435,
-0.07729554921388626,
0.18949632346630096,
-0.307053804397583,
0.008120011538267136,
-0.14583878219127655,
0.19391965866088867,
-0.04866573214530945,
0.0973299965262413,
-0.06036891043186188,
-0.20545724034309387,
-0.22005602717399597,
0.22568300366401672,
0.08247030526399612,
0.230319082736969,
0.3331018388271332,
0.12389546632766724,
0.011817330494523048,
-0.08988376706838608,
-0.047197312116622925,
0.2729225754737854,
-0.07293874025344849,
-0.1080276370048523,
0.01650160551071167,
-0.0516415610909462,
-0.3120226562023163,
-0.038026195019483566,
0.001300151227042079,
0.009226644411683083,
0.42150166630744934,
0.03010040707886219,
0.2655302882194519,
-0.1377224624156952,
-0.1770932525396347,
0.09039842337369919,
0.15037447214126587,
0.05138375982642174,
0.07404552400112152,
-0.06527592986822128,
0.02257644012570381,
-0.091606505215168,
0.09097353368997574,
-0.04479021579027176,
-0.09278728812932968,
-0.007716902997344732,
-0.0658179223537445,
0.07773693650960922,
0.04227035865187645,
-0.19056454300880432,
-0.03747652843594551,
-0.10506653785705566,
-0.04697292670607567,
0.07242955267429352,
0.07578929513692856,
0.10522396117448807,
-0.16748559474945068,
-0.311004102230072,
0.018395887687802315,
0.07992210984230042,
-0.1716841161251068,
0.32192716002464294,
0.1328456997871399,
0.08523906022310257,
0.22587798535823822,
0.3356361389160156,
0.08095654100179672,
-0.35286515951156616,
-0.07989499717950821,
-0.14880135655403137,
-0.053819093853235245,
0.24497079849243164,
-0.04908689484000206,
-0.033341534435749054,
0.0040472568944096565,
0.18350253999233246,
-0.32867416739463806,
0.09125758707523346,
0.06901621073484421,
-0.20976796746253967,
0.15500351786613464,
0.03195574879646301,
-0.017935585230588913,
0.10021413117647171,
-0.05952325463294983,
-0.18272382020950317,
0.09143359214067459,
0.011783605441451073,
-0.011262768879532814,
-0.20725983381271362,
-0.015905478969216347,
0.1598021239042282,
-0.12742550671100616,
0.08004908263683319,
0.28461503982543945,
-0.14672864973545074,
0.016238484531641006,
0.02731831558048725,
-0.25199300050735474,
-0.2502550482749939,
0.05520506575703621,
-0.1815146505832672,
-0.2157449573278427,
-0.0290199127048254,
-0.12734602391719818,
-0.14995169639587402,
0.010721294209361076,
0.14452271163463593,
0.22498756647109985,
-0.3408667743206024,
0.11891891807317734,
-0.21483422815799713,
0.12514980137348175,
-0.22393828630447388,
0.010971631854772568,
-0.4446996748447418,
0.07178081572055817,
0.010772831737995148,
0.08761610090732574,
0.12979204952716827,
0.08242827653884888,
0.19705401360988617,
-0.13795746862888336,
-0.09353358298540115,
-0.14298033714294434,
0.03932907059788704,
0.012787893414497375,
-0.04267926514148712,
0.17931188642978668,
-0.18299661576747894,
0.14508424699306488,
-0.005768726579844952,
-0.22379226982593536,
-0.2255847007036209,
0.07461860775947571,
-0.34175485372543335,
0.009028913453221321,
0.11681849509477615,
-0.05172787606716156,
0.14046703279018402,
-0.1654517948627472,
-0.1491846889257431,
0.051304999738931656,
0.011660086922347546,
-0.21024145185947418,
-0.07755763083696365,
0.16035564243793488,
0.2304675579071045,
-0.00911666639149189,
-0.16742382943630219,
-0.11709221452474594,
0.004786359146237373,
0.1293441653251648,
0.23644901812076569,
-0.4107142686843872,
-0.06591857224702835,
0.05302458256483078,
0.060798417776823044,
-0.1780848205089569,
-0.011995446868240833,
-0.13925635814666748,
-0.08324377238750458,
0.2446189820766449,
0.04230748116970062,
-0.03461450710892677,
0.07734273374080658,
-0.062382496893405914,
0.04427263140678406,
-0.12425347417593002,
0.24344183504581451,
0.11336551606655121,
-0.01952868513762951,
0.04735255241394043,
0.16110587120056152,
0.3339632749557495,
0.07064654678106308,
0.15326961874961853,
0.08543436229228973,
0.01520176138728857,
-0.19512933492660522,
-0.018213365226984024,
-0.039404019713401794,
-0.10412172228097916,
0.2666930556297302,
0.14616942405700684,
0.037403080612421036,
-0.30279985070228577,
-0.12020889669656754,
-0.16760821640491486,
0.011066020466387272,
0.02659759484231472,
0.0817398726940155,
0.2837117612361908,
-0.011584049090743065,
0.1995656043291092,
0.17059236764907837,
0.1134222149848938,
-0.04110615700483322,
0.17488650977611542,
-0.1077929213643074,
-0.03196491673588753,
0.053797438740730286,
-0.015184429474174976,
-0.21005402505397797,
0.11463412642478943,
-0.1545177400112152,
0.03852785751223564,
-0.025888506323099136,
-0.14362481236457825,
0.24524462223052979,
-0.13133814930915833,
0.005402303300797939,
-0.024249684065580368,
-0.03927011415362358,
-0.0840456485748291,
0.1846202164888382,
-0.5234205722808838,
-0.012743594124913216,
-0.17833255231380463,
-0.03232010453939438,
0.03125665336847305,
0.031958211213350296,
-0.07288974523544312,
0.15494529902935028,
-0.17198070883750916,
-0.25141051411628723,
-0.10001688450574875,
-0.12290594726800919,
-0.2188815027475357,
-0.13960228860378265,
0.011845430359244347,
-0.12414465844631195,
0.09853220731019974,
0.07359714061021805,
-0.0959978699684143,
-0.1990223079919815,
-0.06219087168574333,
0.22012118995189667,
-0.018498335033655167,
-0.08862724155187607,
0.013843508437275887,
-0.013119342736899853,
-0.016096414998173714,
0.1802087277173996,
-0.15596641600131989,
0.19632317125797272,
0.09861840307712555,
0.09585742652416229,
-0.029284071177244186,
-0.13138386607170105,
0.015730252489447594,
-0.11824475973844528,
0.0630103126168251,
-0.06146491691470146,
-0.07318232953548431,
0.13432526588439941,
0.0857972502708435,
0.07829594612121582,
0.00023350851552095264,
0.15775421261787415,
-0.15393155813217163,
-0.1671825647354126,
0.06314285844564438,
0.10671188682317734,
-0.44559478759765625,
-0.15064232051372528,
0.1907263845205307,
0.23461681604385376,
0.2890857458114624,
0.08153430372476578,
0.020828401669859886,
-0.14185172319412231,
0.2656539976596832,
-0.2507356107234955,
-0.03906301409006119,
-0.08824022114276886,
-0.11404218524694443,
0.10802516341209412,
0.23176135122776031,
0.08783572167158127,
-0.16678832471370697,
-0.1433655023574829,
0.16633789241313934,
0.021226009353995323,
0.053780537098646164,
-0.08484578877687454,
0.004560435190796852,
0.022630974650382996,
-0.07694099843502045,
-0.10981568694114685,
-0.22701676189899445,
-0.0030975029803812504,
0.21022436022758484,
0.015104411169886589,
0.011082913726568222,
0.20875027775764465,
0.017605774104595184,
0.08022115379571915,
-0.04989922046661377,
-0.15235242247581482,
0.08889639377593994,
0.09915327280759811,
-0.02927090786397457,
0.20814485847949982,
0.08371552079916,
0.3631538450717926,
0.10265083611011505,
0.04733773320913315,
0.013000321574509144,
-0.07473549991846085,
-0.08142895996570587,
-0.04743160307407379,
-0.011505222879350185,
0.021449128165841103,
-0.09724454581737518,
0.031243961304426193,
0.03357042744755745,
-0.27755600214004517,
0.13958224654197693,
-0.15862268209457397,
0.056218307465314865,
0.024456245824694633,
0.20178180932998657,
-0.061972539871931076,
-0.0995263010263443,
0.021499937400221825,
-0.0689866691827774,
0.06528489291667938,
0.040094468742609024,
0.25242477655410767,
-0.02908419631421566,
0.024444540962576866,
0.02432369999587536,
0.1546706110239029,
-0.02808859944343567,
-0.10279161483049393,
-0.011090985499322414,
0.06724874675273895,
-0.037015095353126526,
-0.04264841228723526,
-0.04306044802069664,
-0.20987264811992645,
-0.0288030207157135,
0.01898300088942051,
-0.11053251475095749,
0.10498977452516556,
0.1210307627916336,
-0.17932453751564026,
0.005431205965578556,
0.11364243179559708,
0.11574835330247879,
0.08896283805370331,
-0.057905666530132294,
-0.04995565861463547,
0.16416499018669128,
-0.012824070639908314,
-0.14145943522453308,
-0.1382640153169632,
-0.03093888983130455,
-0.21746647357940674,
0.1702132374048233,
-0.11785583943128586,
0.013905354775488377,
0.35239988565444946,
-0.2527870833873749,
0.011669286526739597,
-0.24855375289916992,
-0.2794099748134613,
0.17862629890441895,
-0.08891725540161133,
-0.1153668463230133,
-0.07247202843427658,
-0.20361924171447754,
-0.05536812171339989,
-0.03396923094987869,
-0.0835890918970108,
0.010253810323774815,
-0.22308726608753204,
0.026441773399710655,
0.07397226989269257,
-0.22369760274887085,
0.06663668900728226,
0.05431681126356125,
0.17134788632392883,
0.11452977359294891,
-0.1774653196334839,
0.12331116199493408,
-0.22032733261585236,
0.14036963880062103,
0.10871218889951706,
-0.18308790028095245,
-0.195457324385643,
0.10061536729335785,
-0.019575823098421097,
0.024305948987603188,
0.03516634181141853,
-0.0769231840968132,
-0.0035860168281942606,
0.06732039898633957,
0.018606387078762054,
0.07709765434265137,
-0.1294185370206833,
-0.01943194307386875,
-0.2330823540687561,
0.004585524555295706,
0.07370620220899582,
-0.20571200549602509,
0.008079363033175468,
0.036481551826000214,
0.13264453411102295,
0.05369071662425995,
-0.2467091679573059,
-0.0650131106376648,
0.09823371469974518,
-0.14186504483222961,
0.290048211812973,
-0.1045827642083168,
-0.04195687547326088,
0.20827315747737885,
-0.33772510290145874,
0.0641150251030922,
0.07415200769901276,
0.12515953183174133,
0.14628946781158447,
0.06610746681690216,
-0.0006151775596663356,
-0.2565036416053772,
0.002585870213806629,
0.2148745059967041,
0.02231769450008869,
-0.203617125749588,
0.023173782974481583,
-0.15878519415855408,
-0.15976843237876892,
0.09028548002243042,
0.005302146542817354,
-0.12253081798553467,
-0.13372918963432312,
-0.0997948944568634,
-0.2212880402803421,
0.0871211439371109,
-0.03768433257937431,
-0.281770259141922,
-0.1127370074391365,
-0.27151697874069214,
-0.08881957083940506,
-0.05494077876210213,
0.16247473657131195,
-0.10318084806203842,
-0.09490303695201874,
0.11729376018047333,
-0.21999190747737885,
-0.2775498926639557,
-0.4087200164794922,
0.08654330670833588,
0.07561567425727844,
-0.1518324911594391,
-0.02076360397040844,
0.062105339020490646,
0.15334683656692505,
-0.1077183187007904,
0.07408901304006577,
0.11721353977918625,
0.36317139863967896,
-0.053884658962488174,
0.07894280552864075,
-0.06729061156511307,
-0.055587224662303925,
-0.0827534943819046,
0.16244065761566162,
-0.1033332347869873,
0.2715887129306793,
-0.2507919371128082,
0.06582266837358475,
0.04977728798985481,
0.10528251528739929,
0.01506126206368208,
-0.08061433583498001,
-0.20158074796199799,
-0.28651803731918335,
-0.25454697012901306,
0.26508626341819763,
-0.13861484825611115,
-0.021849989891052246,
-0.04829476773738861,
0.07538497447967529,
-0.18320822715759277,
0.11186035722494125,
-0.12293223291635513,
-0.09706195443868637,
-0.03230622038245201,
0.2685360312461853,
-0.1545097529888153,
0.04414509981870651,
0.13732564449310303,
0.25229424238204956,
0.046970024704933167,
0.28750672936439514,
0.09430844336748123,
-0.11574144661426544,
0.056178588420152664,
-0.19643180072307587,
-0.009311341680586338,
-0.016165269538760185,
-0.10073158890008926,
0.22537320852279663,
0.17263107001781464,
0.03499748557806015,
-0.0702652856707573,
-0.12138346582651138,
-0.18209756910800934,
0.11006014794111252,
0.1443798691034317,
-0.17029434442520142,
0.061551421880722046,
-0.11616991460323334,
0.0860486850142479,
0.21612751483917236,
0.07711342722177505,
-0.26346421241760254,
0.2207617163658142,
-0.0848521813750267,
-0.004301837645471096,
0.015177672728896141,
-0.28138792514801025,
0.0010649008909240365,
0.11474334448575974,
0.07957317680120468,
-0.015104193240404129,
0.24955245852470398,
-0.16091416776180267,
-0.11026128381490707,
-0.19439654052257538,
-0.027991553768515587,
0.011315782554447651,
0.042963795363903046,
-0.177933007478714,
-0.059595730155706406,
-0.22580480575561523,
-0.0885310098528862,
0.11460722237825394,
0.1810077279806137,
-0.1835426539182663,
0.14309801161289215,
-0.23380041122436523,
-0.10086476057767868,
0.034577298909425735,
0.05931535363197327,
0.17158685624599457,
0.06912119686603546,
0.16990922391414642,
-0.040865518152713776,
-0.013085746206343174,
-0.02820373699069023,
0.15366443991661072,
0.02519468404352665,
-0.2964613735675812,
-0.2847806215286255,
-0.1049749106168747,
0.189200296998024,
-0.035364121198654175,
0.18577468395233154,
-0.003220165614038706,
0.11693724989891052,
-0.29053211212158203,
0.23328754305839539,
-0.07455867528915405,
-0.08852639049291611,
0.03654671832919121,
-0.07287237048149109,
-0.0033822020050138235,
0.31291481852531433,
0.0392833836376667,
-0.2841189205646515,
-0.06879682093858719,
0.04781278967857361,
-0.11109554022550583,
0.016895614564418793,
0.10948910564184189,
0.17283833026885986,
-0.11467186361551285,
0.15559807419776917,
-0.030498724430799484,
0.04916498437523842,
-0.2478957325220108,
-0.07774191349744797,
0.014052155427634716,
-0.2815622389316559,
0.0766286626458168,
0.06329117715358734,
0.11377234011888504,
-0.13821542263031006,
0.23309245705604553,
-0.074667789041996,
-0.1751859188079834,
-0.028543170541524887,
0.030468318611383438,
-0.008338674902915955,
-0.24028925597667694,
0.16033367812633514,
0.03815792128443718,
-0.018781321123242378,
0.12510010600090027,
0.14565177261829376,
-0.19827857613563538,
-0.10886909812688828,
-0.1077766939997673,
-0.1418207734823227,
-0.011624825187027454,
0.01657145470380783,
-0.027883585542440414,
-0.19216160476207733,
0.01459455769509077,
0.09890056401491165,
-0.13759344816207886,
-0.10590874403715134,
-0.11312505602836609,
0.021566852927207947,
-0.04232948645949364,
-0.11704259365797043,
0.043224502354860306,
-0.0834246575832367,
-0.06478827446699142,
-0.07205111533403397,
-0.04817553609609604,
0.15328222513198853,
-0.13232645392417908,
-0.035787977278232574,
0.23297515511512756,
-0.013814780861139297,
-0.109023816883564,
-0.09219478070735931,
-0.07534833997488022,
-0.06058390438556671,
0.01930823177099228,
-0.19693510234355927,
-0.1695505976676941,
-0.011353890411555767,
0.25657033920288086,
0.04112069681286812,
0.09701824188232422,
0.04070582613348961,
0.3348899185657501
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. central line placement. The target glucose infusion rates varies by age .Additional calories can be provided using parenteral lipid emulsion.The use of intravenous insulin drip may be needed to maintain euglycemia and promote anabolism.Manage protein intake to reduce propiogenic precursors; avoidance of protein transiently for <24-36 hours may be required.Transition to enteral feedings should be commenced as soon as they are tolerated (see Prevention of Primary Manifestations, Dietary management).If transition to enteral feedings within 48 hours is not possible, total parenteral nutrition is required.Parenteral amino acid solutions are prescribed based on the recommended daily intake of age-appropriate energy, protein, isoleucine, valine, methionine, and threonine and adjusted using the daily and weekly growth data and plasma amino acid concentrations.Remove toxic compounds.Pharmacologic detoxification:Nitrogen scavenger medications (sodium benzoate, sodium phenylacetate, sodium phenylbutyrate), such as those used in urea cycle disorders to help control ammonia levels | [
-0.05527913197875023,
-0.022394360974431038,
-0.20064818859100342,
-0.34527766704559326,
-0.09064880013465881,
0.04919114336371422,
0.08323412388563156,
-0.29675331711769104,
0.07173959910869598,
-0.06538363546133041,
0.20714867115020752,
-0.09352236986160278,
0.008044175803661346,
-0.08464957028627396,
-0.42123350501060486,
0.07854210585355759,
-0.1539502888917923,
0.12288868427276611,
-0.032195545732975006,
-0.009392555803060532,
0.34417206048965454,
-0.21851657330989838,
0.0732756182551384,
0.12379367649555206,
0.1273866444826126,
0.05902281031012535,
0.2510780394077301,
-0.24389734864234924,
0.22842912375926971,
0.04702756181359291,
0.07969466596841812,
0.06204109638929367,
-0.002507857047021389,
-0.25910478830337524,
-0.04114212095737457,
-0.325178325176239,
-0.06040612980723381,
-0.28115618228912354,
0.09797697514295578,
-0.07398398220539093,
0.09384281933307648,
-0.13475754857063293,
0.15610437095165253,
-0.03978415206074715,
0.14616921544075012,
-0.015638424083590508,
0.04280022904276848,
-0.09103812277317047,
-0.09098294377326965,
0.27879267930984497,
-0.054734133183956146,
-0.10580968856811523,
-0.3679177761077881,
-0.15305905044078827,
0.3300420343875885,
-0.33934932947158813,
-0.05471058189868927,
0.1465124934911728,
-0.06460097432136536,
-0.02925478294491768,
0.0943710133433342,
-0.3470822870731354,
-0.20650388300418854,
-0.35739174485206604,
0.11987879127264023,
-0.11345720291137695,
-0.036072831600904465,
0.22201798856258392,
0.27595019340515137,
-0.21345755457878113,
0.1774817258119583,
-0.1665319949388504,
-0.12652570009231567,
0.1408339887857437,
-0.023253025487065315,
-0.09995608776807785,
0.08499214798212051,
-0.00199231063015759,
-0.003898646915331483,
-0.32018569111824036,
-0.23848415911197662,
0.13393330574035645,
0.004077091813087463,
-0.25977495312690735,
-0.13790427148342133,
0.15637920796871185,
0.26625165343284607,
-0.025974450632929802,
-0.05198388919234276,
0.11960235238075256,
0.1384768933057785,
-0.10314058512449265,
0.018022285774350166,
0.024984419345855713,
0.01642952673137188,
-0.20001445710659027,
0.05938372015953064,
-0.0776539146900177,
-0.20560073852539062,
0.1353624016046524,
0.08319798856973648,
0.08000358194112778,
-0.05804448574781418,
-0.13878045976161957,
-0.1413889080286026,
0.09770125150680542,
-0.3839624524116516,
0.16508744657039642,
0.002203351818025112,
0.0019762509036809206,
0.17914870381355286,
-0.18309386074543,
0.2709973156452179,
0.005990173667669296,
-0.5006536245346069,
-0.18912509083747864,
0.17427514493465424,
0.2070552110671997,
0.053210411220788956,
-0.07012888044118881,
-0.016885630786418915,
0.17505218088626862,
0.1038411483168602,
0.07692999392747879,
0.09602098912000656,
0.022655462846159935,
0.18564532697200775,
-0.03876284137368202,
0.17419441044330597,
-0.2765413224697113,
-0.003437864361330867,
-0.16667169332504272,
0.19329093396663666,
-0.010500418022274971,
0.29436591267585754,
-0.10204479843378067,
-0.26736289262771606,
-0.2757313549518585,
0.22081850469112396,
0.08973091840744019,
0.21199685335159302,
0.3603447675704956,
0.1925288885831833,
-0.002010301686823368,
0.08694040030241013,
0.11325597018003464,
0.23372451961040497,
-0.05562007054686546,
0.02025323361158371,
-0.02357615903019905,
0.020415328443050385,
-0.4006566107273102,
-0.07534076273441315,
0.13405713438987732,
-0.02546754665672779,
0.3240797817707062,
-0.06572061777114868,
0.2804689109325409,
-0.18975697457790375,
-0.14731642603874207,
0.10604977607727051,
-0.043965090066194534,
0.11894524097442627,
0.2002810537815094,
-0.0030542875174432993,
0.09320729970932007,
-0.19559599459171295,
0.11063073575496674,
0.1089194118976593,
-0.0756804496049881,
0.036530159413814545,
-0.06635399162769318,
0.08561079949140549,
0.03609111160039902,
-0.012655668891966343,
0.026804301887750626,
-0.07112961262464523,
-0.17216511070728302,
0.0011487307492643595,
0.24359749257564545,
0.22049397230148315,
-0.15373733639717102,
-0.14185763895511627,
-0.0558227077126503,
0.05447106808423996,
-0.17378810048103333,
0.20077115297317505,
0.11746491491794586,
0.09832913428544998,
0.20655307173728943,
0.2989196479320526,
0.08172754943370819,
-0.2761895954608917,
0.015236475504934788,
-0.06903567910194397,
-0.13565722107887268,
0.2566307783126831,
0.023805666714906693,
0.04624144732952118,
-0.13173417747020721,
-0.014285068958997726,
-0.25397831201553345,
0.10878588259220123,
-0.02166900783777237,
0.0025308262556791306,
0.09413658082485199,
0.06425312161445618,
-0.11106055974960327,
0.13287103176116943,
0.057592108845710754,
-0.07092472910881042,
0.12145689129829407,
-0.004761223215609789,
0.05551567301154137,
-0.28727132081985474,
0.0043154750019311905,
0.13966897130012512,
-0.277133971452713,
0.05532495304942131,
0.2596604824066162,
-0.15382260084152222,
-0.025127381086349487,
-0.004070963244885206,
-0.2596955895423889,
-0.23291566967964172,
0.0788835883140564,
-0.2724182605743408,
-0.17755134403705597,
-0.0364663302898407,
-0.24516941606998444,
-0.18017986416816711,
0.09320536255836487,
0.20535878837108612,
0.33420342206954956,
-0.2408328652381897,
0.027487091720104218,
-0.19343748688697815,
0.322689414024353,
-0.2395952343940735,
0.02639971487224102,
-0.5094907879829407,
0.030425049364566803,
0.02820463851094246,
0.02686116099357605,
0.05401746556162834,
0.19971677660942078,
0.05221421271562576,
-0.03530710190534592,
-0.24267080426216125,
-0.10434090346097946,
-0.01202381681650877,
0.09113359451293945,
0.012971045449376106,
-0.08172304928302765,
-0.29221293330192566,
0.10920407623052597,
0.0874234288930893,
-0.10592985898256302,
-0.16117249429225922,
-0.07830175757408142,
-0.18198063969612122,
0.036626581102609634,
0.18327973783016205,
0.06860194355249405,
0.24654458463191986,
-0.013113758526742458,
-0.0954875573515892,
0.09061893820762634,
-0.05112263187766075,
-0.17851199209690094,
-0.07846267521381378,
-0.008166724815964699,
0.11576845496892929,
0.016513660550117493,
-0.2448018342256546,
-0.16861402988433838,
0.03640960156917572,
0.03559339419007301,
0.24137531220912933,
-0.23288623988628387,
-0.1667679101228714,
0.1532195657491684,
0.04115453362464905,
0.051887739449739456,
-0.05873355269432068,
-0.0809420719742775,
-0.06257615983486176,
0.027555067092180252,
-0.05147337168455124,
0.10940804332494736,
0.0075392574071884155,
0.05202694982290268,
-0.029976360499858856,
-0.11202788352966309,
0.14002589881420135,
0.08472853899002075,
-0.037837497889995575,
0.14404858648777008,
0.07819373905658722,
0.14764726161956787,
0.0065603856928646564,
0.11817573755979538,
0.134843647480011,
-0.10873443633317947,
-0.279753178358078,
0.020642569288611412,
-0.14000831544399261,
-0.06062089651823044,
0.3324272036552429,
0.29864516854286194,
0.18700800836086273,
-0.19958800077438354,
-0.2983740270137787,
-0.047038059681653976,
0.005714921280741692,
0.1479754000902176,
0.011651032604277134,
0.09757120907306671,
0.03826111927628517,
0.05735789239406586,
0.01395126711577177,
0.08659511059522629,
-0.011232768185436726,
-0.04383635148406029,
-0.15738189220428467,
0.018367676064372063,
0.04911460354924202,
-0.010542561300098896,
0.015264412388205528,
0.06916661560535431,
-0.11724197119474411,
0.1978115290403366,
-0.047642990946769714,
-0.1965552717447281,
0.32583311200141907,
-0.2681662142276764,
0.08137411624193192,
0.016294971108436584,
-0.006588480900973082,
0.012522644363343716,
0.11633513122797012,
-0.3442136347293854,
0.013430858962237835,
-0.2840639650821686,
-0.14913401007652283,
0.11041704565286636,
0.036845821887254715,
0.20590485632419586,
0.23636312782764435,
-0.030337996780872345,
-0.1283566653728485,
0.011416495777666569,
-0.1449965387582779,
-0.15817730128765106,
0.040013331919908524,
0.017464330419898033,
-0.06878581643104553,
0.09406521171331406,
0.23677578568458557,
0.10753463953733444,
-0.24058055877685547,
0.0056336321868002415,
0.16975852847099304,
0.021305616945028305,
-0.02402419224381447,
-0.1023736447095871,
-0.19349651038646698,
-0.05639282613992691,
0.22064603865146637,
-0.027769936248660088,
0.09208415448665619,
0.16594448685646057,
0.18010562658309937,
0.03987343981862068,
0.09392368048429489,
0.14151528477668762,
-0.04129454120993614,
-0.048532482236623764,
-0.10618157684803009,
-0.1493380218744278,
0.16331420838832855,
0.013879654929041862,
0.10643418878316879,
-0.07649921625852585,
0.13741876184940338,
0.010398505255579948,
-0.0025349189527332783,
0.08512508124113083,
0.06320101022720337,
-0.5795571208000183,
-0.027871685102581978,
0.218485027551651,
0.07925742864608765,
0.214712455868721,
-0.0015178060857579112,
0.13103492558002472,
0.028596464544534683,
0.13260307908058167,
-0.2674519121646881,
0.05620019510388374,
-0.08686482906341553,
-0.0735485628247261,
0.19212332367897034,
0.06661616265773773,
0.06920254975557327,
-0.11264809221029282,
-0.047841981053352356,
0.08772890269756317,
-0.06092756986618042,
0.033555205911397934,
-0.004013253841549158,
-0.3054713308811188,
0.06296815723180771,
-0.07828498631715775,
0.07041279971599579,
-0.16038134694099426,
-0.16200442612171173,
0.13505668938159943,
0.2028796523809433,
-0.17591939866542816,
0.11818908900022507,
-0.035393573343753815,
-0.02388053946197033,
-0.11953261494636536,
-0.1917858123779297,
0.09231041371822357,
-0.10935939103364944,
-0.0023109051398932934,
0.11275311559438705,
0.19821393489837646,
0.3247326910495758,
0.09399896115064621,
-0.05635231360793114,
-0.0030022200662642717,
0.009540930390357971,
-0.032006051391363144,
-0.27564191818237305,
0.04515217989683151,
0.046069856733083725,
-0.13619083166122437,
0.15411968529224396,
0.11642689257860184,
-0.29961952567100525,
0.13844434916973114,
-0.03224106878042221,
0.11178520321846008,
-0.01689818687736988,
0.3319854736328125,
-0.034365639090538025,
0.06597436219453812,
0.19934408366680145,
-0.1429828554391861,
-0.10030590742826462,
0.06547977775335312,
0.2914851903915405,
-0.09871124476194382,
-0.04075493663549423,
0.037630002945661545,
0.08448924869298935,
-0.09285318106412888,
-0.34109923243522644,
-0.0059803505428135395,
0.17138808965682983,
-0.22269991040229797,
-0.19017527997493744,
0.0014831981388852,
-0.2522805631160736,
-0.06373348087072372,
0.12690018117427826,
-0.08588537573814392,
0.07975012063980103,
0.10049749910831451,
0.002868034178391099,
0.052755653858184814,
0.11254093796014786,
0.07356920093297958,
0.1357499212026596,
-0.07227731496095657,
0.013609858229756355,
0.18403621017932892,
-0.03538621962070465,
-0.1608671098947525,
-0.005162447225302458,
0.019678670912981033,
-0.10463829338550568,
0.2901301383972168,
-0.23954981565475464,
-0.016631638631224632,
0.3580542206764221,
-0.27314022183418274,
0.1235247477889061,
-0.10815200954675674,
-0.2623666524887085,
0.3112429678440094,
-0.20489613711833954,
-0.2165706902742386,
0.030872629955410957,
-0.21345998346805573,
0.04756147041916847,
-0.14971180260181427,
0.008509312756359577,
-0.14572279155254364,
-0.2481611669063568,
0.15280622243881226,
0.009465164504945278,
-0.03551771491765976,
0.10873652249574661,
0.07489228993654251,
-0.03124338574707508,
0.15529726445674896,
0.016301589086651802,
0.06543733179569244,
-0.026432283222675323,
0.15600623190402985,
0.12273073941469193,
-0.20285195112228394,
-0.06515669077634811,
0.22327081859111786,
-0.18040356040000916,
0.08100443333387375,
-0.005420388653874397,
0.05121690034866333,
0.06398330628871918,
-0.0631224662065506,
-0.035941410809755325,
0.06038063392043114,
-0.13165074586868286,
0.02305152267217636,
-0.21449825167655945,
-0.0855303630232811,
0.05568883940577507,
-0.28628289699554443,
0.04159925505518913,
-0.05939667299389839,
0.07222292572259903,
-0.02210947498679161,
-0.1202574223279953,
0.04692243039608002,
-0.04339299350976944,
-0.1624378263950348,
0.29065972566604614,
-0.05614937096834183,
-0.03934745863080025,
0.056073714047670364,
-0.4500444829463959,
0.06519678980112076,
0.014844617806375027,
0.1229349821805954,
0.13421538472175598,
-0.011615621857345104,
-0.02418077550828457,
-0.32078200578689575,
-0.04070649296045303,
0.21003833413124084,
0.03861834853887558,
-0.19378545880317688,
-0.020533470436930656,
-0.10372499376535416,
-0.06985844671726227,
0.0728873535990715,
-0.12590235471725464,
-0.07708123326301575,
-0.14820055663585663,
-0.05065663903951645,
-0.2251194417476654,
0.16670525074005127,
-0.15558476746082306,
-0.18524615466594696,
-0.07992204278707504,
-0.2973760962486267,
-0.011344758793711662,
0.0071702576242387295,
0.0538729727268219,
-0.14471326768398285,
-0.02388232760131359,
0.14059056341648102,
-0.2563733160495758,
-0.2549126446247101,
-0.34341636300086975,
0.14500804245471954,
-0.08913202583789825,
-0.16670523583889008,
0.12246928364038467,
-0.02405671775341034,
0.04141366854310036,
-0.20704074203968048,
0.021064890548586845,
0.11722432076931,
0.45046430826187134,
-0.14088036119937897,
0.12714068591594696,
-0.058043222874403,
0.0535120889544487,
-0.08413812518119812,
0.2180338203907013,
-0.25730112195014954,
0.40943270921707153,
-0.27466249465942383,
-0.028012361377477646,
0.028520772233605385,
0.14800599217414856,
0.016246255487203598,
-0.07401842623949051,
-0.3937222957611084,
-0.2530093193054199,
-0.06606302410364151,
0.2288152277469635,
0.01760469190776348,
-0.1042887270450592,
0.02590925060212612,
0.21997936069965363,
-0.010697651654481888,
0.11068379878997803,
0.030507121235132217,
-0.14181359112262726,
-0.0050625428557395935,
0.32798996567726135,
-0.12509281933307648,
0.030486246570944786,
0.016695987433195114,
0.2940497100353241,
-0.11923269927501678,
0.27721893787384033,
0.16568754613399506,
-0.19535979628562927,
0.10389886796474457,
-0.22761116921901703,
-0.07117339968681335,
-0.11516138166189194,
-0.09175675362348557,
0.12481461465358734,
0.15476444363594055,
0.08070220798254013,
-0.00919362623244524,
-0.10693442076444626,
-0.16211020946502686,
0.11722821742296219,
0.09983363747596741,
-0.258913516998291,
0.1661481112241745,
-0.042997490614652634,
0.07727397978305817,
-0.03451889380812645,
0.15177704393863678,
-0.16263940930366516,
0.15251372754573822,
-0.1786538064479828,
-0.08733716607093811,
-0.032549094408750534,
-0.23806458711624146,
0.040427315980196,
0.10470534861087799,
0.13056635856628418,
0.021568510681390762,
0.3158121407032013,
-0.18431821465492249,
-0.014891129918396473,
-0.15666694939136505,
0.03047754615545273,
-0.03275258094072342,
0.019661525264382362,
0.05394696071743965,
-0.01923387311398983,
-0.04224913939833641,
-0.06322379410266876,
0.1025329977273941,
0.11105028539896011,
-0.20445279777050018,
0.13570700585842133,
-0.11429176479578018,
-0.2575055658817291,
0.04453372582793236,
-0.08507414907217026,
0.2792813777923584,
0.09209451824426651,
0.17683687806129456,
0.14437025785446167,
0.03612120449542999,
-0.18611623346805573,
0.22497542202472687,
0.10042162239551544,
-0.28107750415802,
-0.1343451291322708,
-0.14684364199638367,
0.13045372068881989,
0.08987273275852203,
0.17534038424491882,
-0.021032877266407013,
0.14658856391906738,
-0.31087028980255127,
0.08460866659879684,
-0.12784649431705475,
-0.03551727533340454,
-0.03405770659446716,
-0.15974946320056915,
-0.09505967795848846,
0.34333062171936035,
-0.10908680409193039,
-0.32024720311164856,
-0.1784307062625885,
0.0010463338112458587,
-0.17093397676944733,
-0.009861242957413197,
0.19137176871299744,
0.0023669132497161627,
-0.3907058537006378,
0.19076403975486755,
-0.1320565938949585,
0.016066381707787514,
-0.22091354429721832,
-0.3217722475528717,
-0.07715652137994766,
-0.2794279456138611,
0.024929234758019447,
0.07012583315372467,
0.048971712589263916,
-0.0827689915895462,
0.30730292201042175,
0.013115797191858292,
-0.1251516044139862,
-0.12760862708091736,
0.11921529471874237,
-0.01020068395882845,
-0.05440283939242363,
0.007417590357363224,
-0.07796099036931992,
-0.055129945278167725,
0.1527683287858963,
0.13470815122127533,
-0.06655364483594894,
-0.1983439177274704,
0.059626415371894836,
-0.1553872674703598,
-0.10635101050138474,
-0.06844104081392288,
-0.018553631380200386,
0.012881691567599773,
-0.24513444304466248,
0.23567655682563782,
0.046104513108730316,
-0.04909699410200119,
0.06732506304979324,
0.14570759236812592,
-0.12766031920909882,
-0.11870787292718887,
0.2894512414932251,
0.04472854733467102,
-0.05934210866689682,
-0.1556832194328308,
-0.0764961764216423,
0.064091257750988,
-0.019063202664256096,
-0.009393288753926754,
0.18098191916942596,
-0.11430501937866211,
-0.07589280605316162,
-0.14997775852680206,
-0.24686174094676971,
0.061750248074531555,
-0.03093152865767479,
-0.07925155758857727,
-0.14670218527317047,
-0.038063548505306244,
0.16646161675453186,
0.0077347238548099995,
0.11319077759981155,
0.003550040302798152,
0.3414718508720398
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. .If transition to enteral feedings within 48 hours is not possible, total parenteral nutrition is required.Parenteral amino acid solutions are prescribed based on the recommended daily intake of age-appropriate energy, protein, isoleucine, valine, methionine, and threonine and adjusted using the daily and weekly growth data and plasma amino acid concentrations.Remove toxic compounds.Pharmacologic detoxification:Nitrogen scavenger medications (sodium benzoate, sodium phenylacetate, sodium phenylbutyrate), such as those used in urea cycle disorders to help control ammonia levels during acute decompensations, should be used with caution in the treatment of hyperammonemia associated with PA as they can accentuate frequently observed low plasma glutamine . For a discussion regarding the use of sodium benzoate versus sodium phenylacetate and sodium phenylbutyrate in propionic acidemia see Baumgartner et al .Oral N-carbamoylglutamate (carglumic acid; 100 mg/kg divided every 6 hours in individuals <20 kg and 2. | [
-0.07153390347957611,
0.015232379548251629,
-0.17296524345874786,
-0.23269282281398773,
0.039776094257831573,
0.13573625683784485,
-0.021561266854405403,
-0.2875848412513733,
0.046842001378536224,
0.09268875420093536,
0.12122280150651932,
-0.06293470412492752,
-0.13314689695835114,
0.1122266948223114,
-0.4166904091835022,
0.15349628031253815,
0.1021570935845375,
0.17599880695343018,
-0.1045147255063057,
0.2638387978076935,
0.31970348954200745,
-0.28306272625923157,
0.02902763895690441,
0.23243412375450134,
0.2426477074623108,
-0.07202457636594772,
0.21119633316993713,
-0.28168466687202454,
0.11233391612768173,
0.03674110025167465,
-0.10746179521083832,
0.1347847729921341,
0.01732438988983631,
-0.21909669041633606,
0.04031723737716675,
-0.11618215590715408,
-0.19462014734745026,
-0.2788085341453552,
0.11562193930149078,
-0.23184409737586975,
0.15859125554561615,
-0.11356354504823685,
0.38087549805641174,
-0.0954078957438469,
0.2661985754966736,
-0.06977227330207825,
0.010154500603675842,
-0.12041786313056946,
0.049343664199113846,
0.26452693343162537,
-0.14512163400650024,
-0.09771732985973358,
-0.32776355743408203,
-0.06744944304227829,
0.2829242944717407,
-0.3696872293949127,
-0.1517767608165741,
-0.0527273528277874,
-0.16156189143657684,
-0.015634125098586082,
0.012182272970676422,
-0.3674851357936859,
-0.29832807183265686,
-0.16912142932415009,
0.14991728961467743,
-0.23084428906440735,
-0.061573490500450134,
0.07048209756612778,
0.10786710679531097,
-0.169392392039299,
0.24928736686706543,
-0.008800915442407131,
-0.0899946540594101,
0.008654477074742317,
-0.15173740684986115,
-0.0498863160610199,
0.06726594269275665,
0.09637539088726044,
-0.06052383407950401,
-0.08121796697378159,
-0.42270421981811523,
0.046370357275009155,
0.14179719984531403,
-0.049577746540308,
-0.10510269552469254,
0.08259870111942291,
-0.024079516530036926,
0.06827834248542786,
-0.1296001672744751,
0.22301781177520752,
0.1780388206243515,
0.12213879823684692,
-0.03245510533452034,
-0.13746286928653717,
0.04879109933972359,
-0.10751999914646149,
0.11733316630125046,
-0.16546247899532318,
-0.32391318678855896,
0.20763921737670898,
0.15365563333034515,
0.13469916582107544,
-0.12260911613702774,
-0.09633728861808777,
-0.2592574656009674,
0.1332780420780182,
-0.0933728739619255,
-0.1953132152557373,
-0.013927033171057701,
-0.043451420962810516,
0.16094349324703217,
-0.2750902473926544,
0.3377588391304016,
0.05037004500627518,
-0.6078079342842102,
-0.16484420001506805,
-0.07442779093980789,
0.324085533618927,
0.028055060654878616,
-0.11613771319389343,
-0.024749312549829483,
0.09617812931537628,
0.03252434730529785,
0.21254532039165497,
-0.1749306321144104,
0.12138344347476959,
0.03576352447271347,
-0.08068632334470749,
0.16373619437217712,
-0.2815698981285095,
0.24915391206741333,
0.03771594911813736,
0.04329075291752815,
-0.17252367734909058,
0.20387741923332214,
-0.13229824602603912,
-0.08662605285644531,
-0.2523047626018524,
-0.027975643053650856,
0.28290194272994995,
0.30343374609947205,
0.2663624882698059,
0.23846524953842163,
0.2958545982837677,
0.05000172555446625,
0.012287406250834465,
0.2981748878955841,
-0.16359618306159973,
-0.02486109919846058,
-0.09144750982522964,
-0.22190921008586884,
-0.4068933129310608,
0.03426162526011467,
0.2844027280807495,
-0.19434797763824463,
0.1605306714773178,
0.16693876683712006,
0.2129802703857422,
-0.31536105275154114,
0.07919631898403168,
0.14234057068824768,
-0.024976180866360664,
0.05279454216361046,
0.20970681309700012,
0.0033174746204167604,
0.02744225040078163,
-0.191974475979805,
0.2735676169395447,
-0.04126666486263275,
-0.027934599667787552,
0.03131752833724022,
-0.1625443696975708,
0.123861163854599,
0.15688544511795044,
0.007438515778630972,
0.047637730836868286,
-0.06557102501392365,
-0.23792922496795654,
-0.08170731365680695,
0.12848185002803802,
0.19207143783569336,
0.01131374016404152,
-0.10743822902441025,
0.004073793068528175,
-0.1352778971195221,
-0.40168899297714233,
0.25398358702659607,
0.23205308616161346,
-0.014230725355446339,
0.20961272716522217,
0.2624416947364807,
-0.15271517634391785,
-0.1694215089082718,
0.018632585182785988,
0.21093212068080902,
-0.3566385507583618,
0.3339940309524536,
-0.03343630209565163,
0.19636741280555725,
0.09488856792449951,
-0.2372547686100006,
-0.03614237159490585,
0.27074363827705383,
0.15504342317581177,
-0.1462290734052658,
-0.009318907745182514,
0.11095347255468369,
-0.1532643586397171,
0.08977004140615463,
-0.1459561437368393,
-0.16643556952476501,
0.22875718772411346,
-0.19466812908649445,
0.0668652281165123,
-0.4926393926143646,
0.020413443446159363,
0.06458526104688644,
-0.39456191658973694,
-0.14693093299865723,
0.2827688753604889,
-0.28700071573257446,
0.040787823498249054,
0.42687293887138367,
-0.069756880402565,
-0.021381912752985954,
-0.05420580133795738,
-0.38705649971961975,
-0.015185859054327011,
-0.017109805718064308,
-0.29357877373695374,
-0.2347288578748703,
0.15600286424160004,
-0.11878370493650436,
0.3907047212123871,
-0.35080257058143616,
0.055546704679727554,
-0.23314808309078217,
0.29366523027420044,
-0.317208856344223,
0.04471030458807945,
-0.47978729009628296,
0.15319430828094482,
0.07711923867464066,
-0.068972647190094,
-0.04513845592737198,
0.07347266376018524,
-0.15018774569034576,
-0.19187934696674347,
0.021383928135037422,
-0.2698535919189453,
-0.11011388897895813,
0.01125873439013958,
0.03131531924009323,
-0.22725015878677368,
-0.4330782890319824,
-0.1452208012342453,
0.02387271635234356,
0.07784369587898254,
0.0294871237128973,
0.1312340348958969,
-0.21194566786289215,
0.1048865094780922,
-0.04481154680252075,
0.1352050006389618,
-0.010173656046390533,
-0.05033442750573158,
-0.1432957649230957,
0.09852466732263565,
-0.2546103894710541,
-0.23257309198379517,
-0.16776753962039948,
0.16840395331382751,
-0.037039320915937424,
0.09158855676651001,
-0.38965290784835815,
-0.3304407298564911,
0.06057601422071457,
0.08570505678653717,
0.029136624187231064,
-0.03886261582374573,
-0.051800437271595,
0.23003451526165009,
-0.06081470102071762,
0.11638519912958145,
0.10730025917291641,
0.05535988509654999,
-0.021616777405142784,
0.13052193820476532,
-0.1330016553401947,
0.01527615450322628,
0.04923364147543907,
0.035595618188381195,
0.0021372141782194376,
-0.2869247496128082,
0.14741937816143036,
0.2876390516757965,
0.15732412040233612,
0.14244408905506134,
0.10373041033744812,
0.25158482789993286,
0.06878890842199326,
0.10045266896486282,
0.20772568881511688,
-0.29147279262542725,
-0.2916698157787323,
-0.06026463210582733,
-0.041438449174165726,
-0.03577035292983055,
0.24750098586082458,
0.5073967576026917,
0.20512400567531586,
0.024047689512372017,
-0.04833938926458359,
0.008148128166794777,
-0.1758250743150711,
0.2785426080226898,
0.06744001060724258,
0.09399750828742981,
0.10149335116147995,
0.055361129343509674,
0.027156418189406395,
0.0462023988366127,
0.015005347318947315,
0.06823395192623138,
-0.16606150567531586,
-0.2826436758041382,
0.1697966307401657,
-0.07086031883955002,
0.08460575342178345,
0.10400561988353729,
-0.1124376431107521,
0.2363629937171936,
-0.005259057506918907,
0.02361983247101307,
0.49022743105888367,
-0.16660481691360474,
0.16532987356185913,
-0.06423530727624893,
-0.20564861595630646,
-0.04731806367635727,
0.19340260326862335,
-0.3620668649673462,
0.1439875066280365,
-0.38705936074256897,
-0.29568034410476685,
-0.15042544901371002,
-0.05675052851438522,
0.26729923486709595,
0.24023552238941193,
0.0021533446852117777,
-0.013345343992114067,
0.08957403898239136,
0.04743441939353943,
0.029594147577881813,
0.0970105454325676,
-0.08480188250541687,
-0.18192946910858154,
-0.04218573495745659,
0.4034624397754669,
0.032234374433755875,
-0.39041459560394287,
0.1115288957953453,
-0.000966590188909322,
-0.0664423480629921,
0.12106887996196747,
-0.1881699115037918,
-0.1004183441400528,
-0.05913529917597771,
0.039617665112018585,
-0.11708719283342361,
-0.10681085288524628,
0.19743375480175018,
0.25098511576652527,
0.18257546424865723,
0.060999877750873566,
0.0849699079990387,
-0.07921462506055832,
0.09678042680025101,
-0.29772430658340454,
-0.41668277978897095,
0.14749443531036377,
-0.03202112391591072,
-0.1399347186088562,
-0.04530863091349602,
-0.04538794979453087,
-0.06563566625118256,
-0.0006111327675171196,
0.1525428295135498,
0.26426807045936584,
-0.6094930768013,
0.10160442441701889,
0.079493448138237,
0.10893405973911285,
0.27798908948898315,
-0.07203793525695801,
0.06718116998672485,
0.08315759152173996,
0.045757684856653214,
-0.3029494285583496,
0.33709487318992615,
-0.05266888439655304,
-0.016887763515114784,
0.15359005331993103,
0.2864573299884796,
0.0619579441845417,
0.06935839354991913,
-0.17448903620243073,
0.14533154666423798,
-0.3279224932193756,
-0.11934080719947815,
0.0058560981415212154,
-0.35461655259132385,
-0.09044495970010757,
0.016056815162301064,
-0.01130459550768137,
-0.17397703230381012,
-0.16842907667160034,
0.21351589262485504,
0.24482233822345734,
0.14653471112251282,
0.19489319622516632,
-0.01024487242102623,
-0.04435800388455391,
-0.2526991069316864,
-0.24783995747566223,
-0.004014033358544111,
0.030135318636894226,
0.08615804463624954,
0.051038701087236404,
0.34389379620552063,
0.22522103786468506,
0.016348393633961678,
0.167336568236351,
-0.21516361832618713,
-0.1658090054988861,
-0.01798243075609207,
-0.2590562105178833,
0.017361069098114967,
-0.07973556220531464,
-0.0007806348730809987,
0.11761123687028885,
-0.027251148596405983,
-0.03148433938622475,
0.2417040467262268,
-0.246819406747818,
0.07423943281173706,
0.07452753931283951,
0.24280554056167603,
0.11037475615739822,
0.11783148348331451,
0.047143083065748215,
-0.17009061574935913,
-0.04010315239429474,
-0.011332442052662373,
-0.07754062116146088,
-0.028631480410695076,
-0.09529664367437363,
-0.05271575599908829,
0.1549609899520874,
0.03507291153073311,
-0.3102568984031677,
0.2710960805416107,
0.19806283712387085,
-0.1534596085548401,
-0.1964440792798996,
0.1629679948091507,
-0.20589038729667664,
-0.05681206285953522,
0.2439258098602295,
-0.009612339548766613,
0.15645815432071686,
-0.011701630428433418,
-0.19678932428359985,
0.12259197235107422,
-0.1167927086353302,
-0.060171939432621,
0.09572283178567886,
-0.0661359503865242,
0.009602315723896027,
0.06650720536708832,
-0.09325595945119858,
0.009550916962325573,
0.215927854180336,
-0.20235270261764526,
-0.10690945386886597,
0.02580065280199051,
-0.27207136154174805,
-0.10695455968379974,
0.4350162148475647,
-0.1629299372434616,
0.10259547084569931,
-0.056404050439596176,
-0.061723172664642334,
0.10370472073554993,
-0.10407805442810059,
-0.18431048095226288,
-0.018567359074950218,
-0.1419738084077835,
-0.02688021771609783,
-0.14408288896083832,
0.15792466700077057,
-0.25381383299827576,
-0.30993545055389404,
-0.0609707236289978,
-0.1182936355471611,
-0.05253838747739792,
0.009943727403879166,
0.019417282193899155,
-0.011434653773903847,
0.1646324098110199,
0.1531411111354828,
0.24612726271152496,
-0.08903627097606659,
0.013101927936077118,
-0.01433082390576601,
-0.16209617257118225,
-0.08291831612586975,
0.14309804141521454,
0.07223229855298996,
-0.16778822243213654,
0.25112032890319824,
0.04871046915650368,
0.07418762147426605,
-0.1686304211616516,
0.11424960941076279,
-0.109843410551548,
0.10647695511579514,
0.2874569296836853,
-0.09449630975723267,
-0.30815389752388,
0.31405073404312134,
-0.2783268094062805,
-0.09218581020832062,
-0.08761048316955566,
0.44420307874679565,
-0.035665012896060944,
-0.0556759387254715,
-0.06758225709199905,
0.03985525667667389,
-0.2215612530708313,
-0.09240182489156723,
-0.003920234274119139,
0.044786736369132996,
-0.12036363780498505,
-0.505154550075531,
0.3198031783103943,
0.07033577561378479,
0.03413958102464676,
0.2079554945230484,
-0.09611480683088303,
-0.12010876089334488,
-0.1717502474784851,
-0.11707758158445358,
0.2443499118089676,
-0.0019930133130401373,
-0.19677405059337616,
-0.05651574954390526,
-0.250720739364624,
-0.15253987908363342,
0.2169702798128128,
0.16334348917007446,
-0.03162036091089249,
-0.23865815997123718,
0.0977058932185173,
-0.23210373520851135,
0.19144630432128906,
-0.17124639451503754,
-0.16205626726150513,
0.05540073290467262,
-0.3210570216178894,
-0.05623796954751015,
-0.027570132166147232,
0.17651773989200592,
-0.06116756424307823,
-0.017099648714065552,
0.3337389826774597,
-0.15955832600593567,
-0.24004638195037842,
-0.35741767287254333,
0.3593254089355469,
-0.100450798869133,
-0.20119310915470123,
0.009351199492812157,
-0.029588475823402405,
0.14985260367393494,
0.07294553518295288,
0.13629086315631866,
0.02277398854494095,
0.48562538623809814,
0.046091675758361816,
0.10207732021808624,
-0.26416248083114624,
-0.014504517428576946,
0.0377252958714962,
0.12634430825710297,
-0.25346270203590393,
0.448259174823761,
-0.13079223036766052,
-0.010675305500626564,
0.06399831920862198,
0.28203609585762024,
0.13757361471652985,
0.07512658089399338,
-0.07842772454023361,
-0.03134450316429138,
-0.1031528115272522,
0.2339337319135666,
-0.037701014429330826,
-0.16477102041244507,
0.12053974717855453,
0.2508653402328491,
-0.01052848156541586,
0.17398913204669952,
0.0017219380242750049,
-0.13685283064842224,
0.2870018482208252,
0.15068745613098145,
-0.022073036059737206,
-0.046603552997112274,
-0.0067109218798577785,
0.31795400381088257,
-0.24444562196731567,
0.07400572299957275,
0.06332027167081833,
-0.2096482664346695,
0.0323493629693985,
-0.08195330202579498,
-0.19518838822841644,
-0.02086462639272213,
-0.15645425021648407,
0.028260990977287292,
0.2632998824119568,
0.062040213495492935,
-0.14161942899227142,
-0.14338769018650055,
-0.11186806857585907,
0.00712896604090929,
-0.014160770922899246,
-0.19125871360301971,
0.30942416191101074,
-0.1315738558769226,
0.016950272023677826,
0.044583965092897415,
0.1428050696849823,
-0.29851481318473816,
0.1981257200241089,
-0.08536860346794128,
0.06270900368690491,
0.17118021845817566,
-0.26497766375541687,
0.07664744555950165,
0.10945718735456467,
0.13634520769119263,
0.12436290085315704,
0.39254477620124817,
-0.08336324244737625,
0.16233809292316437,
-0.08918371051549911,
0.08311676234006882,
-0.2700570821762085,
0.21685141324996948,
0.13759265840053558,
0.018648013472557068,
-0.026239164173603058,
-0.17987138032913208,
0.17618991434574127,
0.0020783485379070044,
-0.2872442901134491,
0.17212560772895813,
-0.3219892978668213,
-0.07725705951452255,
-0.07104505598545074,
0.029365060850977898,
0.13154129683971405,
0.08701704442501068,
-0.08083983510732651,
0.24689145386219025,
0.13368694484233856,
-0.13900122046470642,
0.3428373634815216,
0.11324132233858109,
-0.27088066935539246,
-0.2068907469511032,
-0.030544517561793327,
0.1491411328315735,
0.20613913238048553,
0.12169405817985535,
0.147679403424263,
0.12439919263124466,
-0.23853448033332825,
0.08730802685022354,
-0.07981780171394348,
0.17245279252529144,
-0.047054752707481384,
-0.052749305963516235,
0.12708310782909393,
0.6160463094711304,
-0.2768371105194092,
-0.3798610270023346,
-0.3731783628463745,
-0.06236400082707405,
-0.038013000041246414,
0.125751331448555,
0.18402186036109924,
-0.043959494680166245,
-0.36569949984550476,
0.2553364932537079,
0.05256194248795509,
0.013930605724453926,
-0.12308978289365768,
-0.24219590425491333,
-0.4294653534889221,
-0.16005168855190277,
0.075629323720932,
-0.023199759423732758,
0.04238515347242355,
-0.09366194158792496,
0.30372291803359985,
-0.13641086220741272,
-0.15072545409202576,
-0.14863321185112,
-0.010631676763296127,
0.006572647485882044,
-0.0724760890007019,
0.0683586373925209,
-0.18089042603969574,
-0.05316755175590515,
0.10112469643354416,
0.058123938739299774,
-0.13490791618824005,
-0.26678675413131714,
-0.0731818750500679,
-0.3165242075920105,
-0.09670495986938477,
-0.030145036056637764,
-0.1029474288225174,
-0.10137500613927841,
-0.1339610368013382,
-0.11267533153295517,
-0.002726025180891156,
-0.04342256858944893,
0.2749389410018921,
0.11028019338846207,
0.05958956852555275,
0.004936096724122763,
0.32565078139305115,
0.03439377248287201,
-0.14873391389846802,
-0.5112540125846863,
-0.16702622175216675,
0.03596891090273857,
0.27656498551368713,
-0.03495503589510918,
0.25962957739830017,
0.02553686872124672,
0.09756381064653397,
-0.18996098637580872,
-0.08757910132408142,
0.17773520946502686,
-0.022915715351700783,
-0.124261774122715,
-0.025009432807564735,
-0.2181866616010666,
-0.06380239874124527,
-0.16806404292583466,
0.2660262882709503,
0.024569258093833923,
0.13840557634830475
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK92946/ | QE2k7oK | Propionic Acidemia | C0268579 | 31,762 | propionic acidemia. disorders to help control ammonia levels during acute decompensations, should be used with caution in the treatment of hyperammonemia associated with PA as they can accentuate frequently observed low plasma glutamine . For a discussion regarding the use of sodium benzoate versus sodium phenylacetate and sodium phenylbutyrate in propionic acidemia see Baumgartner et al .Oral N-carbamoylglutamate (carglumic acid; 100 mg/kg divided every 6 hours in individuals <20 kg and 2.2 gm/m2 in individuals >20 kg) can aid in the detoxification of ammonia during neonatal and acute decompensations .Extracorporeal detoxification is required for persistent acidosis and hyperammonemia (plasma ammonia level >250-300 μmol/L) not responding to fluid and drug treatment. Methods include (depending on age and clinical situation) continuous veno-venous hemofiltration, extracorporeal membrane oxygenation, or hemodialysis .Carnitine supplementation (100 mg/kg/day | [
-0.05174712464213371,
-0.04385291412472725,
0.007189522031694651,
-0.24122808873653412,
0.09891286492347717,
0.17145107686519623,
-0.03679320588707924,
-0.30710625648498535,
0.014656455256044865,
0.12068083882331848,
0.17270950973033905,
-0.00648186169564724,
-0.11662078648805618,
0.10732997208833694,
-0.2963641285896301,
0.01669876091182232,
0.15687346458435059,
0.005291915964335203,
-0.2667889893054962,
0.25986969470977783,
0.2211655080318451,
-0.19818471372127533,
-0.018371542915701866,
0.32768404483795166,
0.2825387418270111,
-0.034173280000686646,
0.21926091611385345,
-0.3160593509674072,
0.10564392805099487,
0.17820918560028076,
-0.13462287187576294,
-0.07837743312120438,
0.1361791342496872,
-0.1899242401123047,
-0.04463375732302666,
0.009208661504089832,
-0.2326831817626953,
-0.2397550642490387,
0.1141301617026329,
-0.37085551023483276,
0.1413346379995346,
-0.19257420301437378,
0.48245474696159363,
-0.0026240248698741198,
0.20278140902519226,
-0.1676521599292755,
0.023341255262494087,
-0.041129302233457565,
-0.1105065569281578,
0.15227141976356506,
0.06102906912565231,
-0.15127381682395935,
-0.2674660086631775,
-0.08437593281269073,
0.4046364426612854,
-0.2740238308906555,
-0.03870692104101181,
0.04879999905824661,
-0.21589317917823792,
-0.011349095962941647,
-0.01107735838741064,
-0.36132508516311646,
-0.3038925230503082,
-0.24894139170646667,
0.025126583874225616,
-0.14823980629444122,
-0.05730000510811806,
-0.05079418420791626,
0.22950030863285065,
-0.14269471168518066,
0.22810420393943787,
0.0023182097356766462,
-0.042089615017175674,
0.01437164843082428,
-0.2720281779766083,
-0.02334442175924778,
-0.011481319554150105,
0.03709225729107857,
0.0068754395470023155,
-0.12072502076625824,
-0.34050509333610535,
-0.03376566991209984,
0.012111697345972061,
0.05541811138391495,
-0.09813840687274933,
-0.06394213438034058,
0.24051237106323242,
0.05335189029574394,
-0.09050317853689194,
0.09119606763124466,
0.009126871824264526,
-0.01795305497944355,
-0.14413201808929443,
-0.05063923820853233,
0.15317904949188232,
-0.09918045252561569,
0.21948665380477905,
-0.1977534145116806,
-0.31964296102523804,
0.2044731229543686,
0.12873610854148865,
0.06308688968420029,
-0.09048061072826385,
-0.16281689703464508,
-0.041711434721946716,
0.03954404592514038,
-0.04062744230031967,
-0.013815200887620449,
0.055989932268857956,
0.01836942695081234,
0.2516387701034546,
-0.31692296266555786,
0.5413687229156494,
0.04039798304438591,
-0.48978349566459656,
-0.23831982910633087,
-0.11300218850374222,
0.20648643374443054,
-0.045224085450172424,
-0.18123896420001984,
0.033760443329811096,
0.01940978318452835,
0.07788268476724625,
0.04317043349146843,
-0.11329072713851929,
0.09830351173877716,
0.13132646679878235,
-0.1172807365655899,
0.2078942209482193,
-0.3865288197994232,
0.24901652336120605,
-0.018743939697742462,
-0.05826960876584053,
-0.09327725321054459,
0.20568403601646423,
0.011124620214104652,
-0.09472143650054932,
-0.30175402760505676,
-0.019934840500354767,
0.09645210206508636,
0.2468087375164032,
0.16185684502124786,
0.18034212291240692,
0.17685730755329132,
0.21740417182445526,
0.07421999424695969,
0.1819942742586136,
-0.1317816823720932,
0.0038188372272998095,
-0.11182136088609695,
-0.1549813449382782,
-0.29549553990364075,
-0.024454329162836075,
0.25555723905563354,
-0.21617871522903442,
0.08215159922838211,
0.07000920176506042,
0.1975255310535431,
-0.10752283036708832,
0.05755675211548805,
0.04557212069630623,
-0.03365765139460564,
-0.09998299926519394,
0.16675026714801788,
0.03406527265906334,
-0.08862896263599396,
-0.27973711490631104,
0.29702508449554443,
0.004479169845581055,
-0.21048811078071594,
-0.036938659846782684,
0.010852661915123463,
0.054884426295757294,
0.12202539294958115,
0.1315457671880722,
-0.13951218128204346,
-0.019304465502500534,
-0.15449579060077667,
-0.005688411183655262,
0.13959462940692902,
0.16556401550769806,
-0.010201144963502884,
-0.1369740068912506,
0.06275786459445953,
-0.10448537766933441,
-0.3082614541053772,
0.21697969734668732,
0.20459724962711334,
-0.03740021958947182,
0.1726199984550476,
0.24655196070671082,
-0.1852305382490158,
-0.10013364255428314,
-0.045704435557127,
0.2941998243331909,
-0.2431909143924713,
0.2632185220718384,
0.02375081367790699,
0.14220261573791504,
0.06415604799985886,
-0.2641201317310333,
-0.15354031324386597,
0.3582285940647125,
0.11677861213684082,
-0.2785457372665405,
0.008194276131689548,
0.13517481088638306,
-0.33933693170547485,
0.052173033356666565,
-0.09712129086256027,
-0.12792283296585083,
0.22435694932937622,
-0.22163544595241547,
-0.039159130305051804,
-0.5002632141113281,
0.0854794904589653,
-0.059903454035520554,
-0.3765811324119568,
-0.055434685200452805,
0.3408755660057068,
-0.1297730952501297,
-0.020016208291053772,
0.4496455490589142,
-0.15620994567871094,
-0.18334025144577026,
-0.11731299012899399,
-0.36998647451400757,
-0.09486150741577148,
0.0874752625823021,
-0.16301952302455902,
-0.1934882551431656,
-0.027035806328058243,
-0.13700248301029205,
0.3198586106300354,
-0.2794998288154602,
0.06459008902311325,
-0.3422793745994568,
0.172379732131958,
-0.22709666192531586,
-0.058612339198589325,
-0.3054608106613159,
0.08154642581939697,
0.03316809982061386,
-0.11666092276573181,
-0.10540637373924255,
0.14882029592990875,
-0.22859399020671844,
-0.14302624762058258,
0.21243441104888916,
-0.17447763681411743,
-0.028452817350625992,
0.07373294979333878,
0.1459609866142273,
-0.18957552313804626,
-0.2765007019042969,
-0.12005208432674408,
0.04650197923183441,
0.019909266382455826,
0.06133100017905235,
0.07382052391767502,
-0.09504060447216034,
0.031021684408187866,
-0.1350385546684265,
0.22770337760448456,
-0.19452087581157684,
-0.03295512497425079,
-0.1831706464290619,
0.22419612109661102,
-0.1899850219488144,
-0.2227018177509308,
-0.13284878432750702,
0.23647864162921906,
0.02989024482667446,
0.08780452609062195,
-0.3408871293067932,
-0.3604193925857544,
0.24116753041744232,
0.17388387024402618,
0.042621415108442307,
-0.12864939868450165,
-0.011311054229736328,
0.20459461212158203,
-0.003254557028412819,
0.15138454735279083,
0.3456987738609314,
0.07764513790607452,
-0.09846115857362747,
0.13332760334014893,
-0.1187407597899437,
0.11199906468391418,
0.08835787326097488,
-0.008358626626431942,
0.08543840050697327,
-0.1350453644990921,
0.2770668566226959,
0.21437859535217285,
0.08449659496545792,
0.02874361351132393,
0.1634257733821869,
0.2178807109594345,
0.18036627769470215,
-0.07541175186634064,
0.11203634738922119,
-0.2533547878265381,
-0.11255599558353424,
-0.04167221114039421,
-0.041660409420728683,
-0.09243516623973846,
0.1401532143354416,
0.3680872321128845,
0.15170259773731232,
-0.01701486110687256,
-0.15694256126880646,
-0.028127534314990044,
-0.0637870728969574,
0.2254020869731903,
-0.14294315874576569,
0.2457570731639862,
0.1717853844165802,
0.03206893429160118,
0.1442699283361435,
0.10333140194416046,
0.10714051872491837,
0.0869164988398552,
-0.06418990343809128,
-0.12735217809677124,
0.11564645916223526,
-0.03700985386967659,
0.12406844645738602,
0.07837770879268646,
-0.05319179221987724,
0.2262483686208725,
-0.13135354220867157,
-0.15598183870315552,
0.3342990279197693,
-0.049458831548690796,
0.26143941283226013,
-0.27796652913093567,
-0.18070586025714874,
-0.05367530509829521,
0.1820588856935501,
-0.3513250946998596,
0.06687644124031067,
-0.26802578568458557,
-0.2913416028022766,
-0.0787101611495018,
0.004599942360073328,
0.27422162890434265,
0.17731164395809174,
-0.11863183230161667,
-0.019605660811066628,
0.0708371102809906,
0.0000164415905601345,
-0.09843254834413528,
0.15727661550045013,
-0.056955594569444656,
-0.09407384693622589,
-0.03722947835922241,
0.27826565504074097,
-0.01209705788642168,
-0.22925810515880585,
-0.0802675262093544,
0.05737549066543579,
0.04326815903186798,
0.10078299045562744,
-0.27702754735946655,
-0.10802879929542542,
-0.01953520067036152,
0.05506165698170662,
-0.0363987497985363,
-0.058119483292102814,
-0.11733585596084595,
0.21299470961093903,
0.2366734892129898,
0.06827535480260849,
-0.014301788993179798,
-0.10754842311143875,
0.08263412117958069,
-0.22569888830184937,
-0.36081060767173767,
0.2534139156341553,
-0.029381614178419113,
-0.09063125401735306,
0.0711888000369072,
-0.18416695296764374,
-0.028911827132105827,
-0.014065798372030258,
0.12357299774885178,
0.2326480597257614,
-0.6607930660247803,
0.07023033499717712,
0.05566132813692093,
0.15707841515541077,
0.35199040174484253,
-0.11202321201562881,
0.1135016605257988,
0.1559603214263916,
-0.16034628450870514,
-0.18410411477088928,
0.32477864623069763,
-0.059341900050640106,
0.09997761994600296,
0.04181915521621704,
0.3468865752220154,
0.09848711639642715,
0.12065286934375763,
-0.20449955761432648,
0.1678009033203125,
-0.3725792467594147,
-0.018883656710386276,
-0.06604363769292831,
-0.3405013382434845,
-0.019389957189559937,
-0.09983181208372116,
0.12125178426504135,
-0.14123648405075073,
-0.14846208691596985,
0.20216664671897888,
0.14541791379451752,
0.14095652103424072,
0.2163558453321457,
0.044043928384780884,
0.08608047664165497,
-0.1739090085029602,
-0.19990850985050201,
0.05313202366232872,
0.11803928762674332,
0.11827895045280457,
0.05490011349320412,
0.3323635458946228,
0.2996571958065033,
0.12091664224863052,
-0.050804849714040756,
-0.2363899052143097,
-0.2425890862941742,
0.09803521633148193,
-0.2916334271430969,
-0.014094801619648933,
-0.04831183701753616,
-0.05161360651254654,
0.14013315737247467,
-0.026111586019396782,
-0.08789222687482834,
0.1655791699886322,
-0.2936136722564697,
-0.10217022895812988,
0.05818164348602295,
0.3423658013343811,
0.12099874019622803,
0.1103469505906105,
0.04519912227988243,
-0.24557992815971375,
-0.06373802572488785,
-0.05632777139544487,
-0.01349787600338459,
0.09053688496351242,
-0.10237711668014526,
-0.16891025006771088,
0.06292732805013657,
-0.04842503368854523,
-0.2096954882144928,
0.27570995688438416,
0.3202386498451233,
-0.2609403431415558,
-0.2144983857870102,
0.07852636277675629,
-0.10355377197265625,
-0.04110794886946678,
0.1932022124528885,
0.13119961321353912,
0.1742025911808014,
0.03630786016583443,
-0.19772738218307495,
0.11150768399238586,
-0.09344378858804703,
-0.14651131629943848,
0.1550539880990982,
0.03914574533700943,
0.02413494698703289,
0.0794801339507103,
-0.20208793878555298,
-0.009837090969085693,
0.19990591704845428,
-0.14825212955474854,
-0.13408872485160828,
-0.04397476464509964,
-0.247351735830307,
-0.05216764658689499,
0.4488314092159271,
-0.16145752370357513,
0.0425388365983963,
-0.10560183227062225,
0.00038407070678658783,
0.1975974589586258,
0.06585675477981567,
-0.06064381077885628,
0.04340272769331932,
-0.06615787744522095,
-0.12012949585914612,
-0.15750327706336975,
0.068173348903656,
-0.16383223235607147,
-0.28337058424949646,
-0.04511326923966408,
0.024264046922326088,
0.03373777121305466,
0.043512534350156784,
-0.1355501413345337,
0.02268359065055847,
0.23483145236968994,
0.141720712184906,
0.2277960628271103,
-0.13337942957878113,
-0.06070895120501518,
0.0030519498977810144,
-0.3269544243812561,
0.1123799979686737,
0.20547175407409668,
0.13413891196250916,
0.10388340055942535,
0.28886106610298157,
0.0022294078953564167,
-0.1165648028254509,
-0.13181136548519135,
0.13583149015903473,
-0.0736934021115303,
-0.0050093038007617,
0.27106717228889465,
-0.05992160364985466,
-0.3083289563655853,
0.24779875576496124,
-0.2912501394748688,
-0.04014230892062187,
-0.0947534441947937,
0.2775989770889282,
-0.08738499879837036,
-0.0036847081501036882,
-0.19970688223838806,
-0.07120832800865173,
-0.21587203443050385,
0.1489560306072235,
0.03886756673455238,
0.07280699908733368,
-0.009308175183832645,
-0.41371679306030273,
0.38158851861953735,
0.07566478103399277,
0.06464289128780365,
0.3460165858268738,
-0.16353477537631989,
-0.27142849564552307,
-0.055554162710905075,
-0.2273801565170288,
0.12207798659801483,
0.07941453903913498,
-0.0668141096830368,
-0.14848503470420837,
-0.19393041729927063,
-0.15855270624160767,
0.18299059569835663,
0.07343580573797226,
0.05488665774464607,
-0.23100978136062622,
0.08301609754562378,
-0.26542147994041443,
0.21952547132968903,
-0.2671569883823395,
-0.2111642211675644,
0.07004211097955704,
-0.31232020258903503,
0.08082931488752365,
-0.049936238676309586,
0.25605514645576477,
-0.236017644405365,
-0.025170866400003433,
0.28669920563697815,
-0.09221457690000534,
-0.38605913519859314,
-0.36105960607528687,
0.3655666410923004,
-0.00673600984737277,
-0.20971991121768951,
0.06232498213648796,
-0.01214000303298235,
0.15863053500652313,
0.11708158254623413,
-0.02623666636645794,
0.018551645800471306,
0.3984086513519287,
0.07854176312685013,
0.056861650198698044,
-0.22143271565437317,
0.05530421435832977,
0.05644698068499565,
0.055122412741184235,
-0.2802795171737671,
0.45947375893592834,
-0.115713931620121,
0.16478481888771057,
0.12187112122774124,
0.2595389783382416,
0.27622243762016296,
-0.06712845712900162,
0.04041309654712677,
-0.029490109533071518,
-0.06992404907941818,
0.17248517274856567,
-0.13951629400253296,
-0.3247121572494507,
0.21131619811058044,
-0.008656625635921955,
0.11035848408937454,
0.039170704782009125,
0.06857625395059586,
0.23943032324314117,
0.3137735426425934,
0.21532081067562103,
0.10197854787111282,
-0.022505689412355423,
-0.005225102882832289,
0.29851406812667847,
-0.14392180740833282,
0.19230028986930847,
-0.017983291298151016,
-0.15449857711791992,
0.10534202307462692,
-0.0372239425778389,
-0.1363537460565567,
0.027419880032539368,
-0.1358463615179062,
-0.04329213127493858,
0.3430631458759308,
0.1601499319076538,
-0.03211146220564842,
-0.1506803333759308,
0.06637801229953766,
-0.030433405190706253,
0.016542764380574226,
-0.24144990742206573,
0.13244299590587616,
-0.267292857170105,
0.1055811196565628,
0.07919294387102127,
0.033484019339084625,
-0.15595538914203644,
0.04474421218037605,
-0.12341181188821793,
0.08696479350328445,
0.09052352607250214,
-0.1447780579328537,
0.16312870383262634,
0.13372884690761566,
0.18742813169956207,
0.17660324275493622,
0.2323284149169922,
0.017454227432608604,
0.14997035264968872,
-0.11462685465812683,
-0.0017999551491811872,
-0.21889789402484894,
0.28362223505973816,
0.14600366353988647,
-0.010684361681342125,
-0.05452467501163483,
0.04199450835585594,
0.13376350700855255,
0.09272059053182602,
-0.43505197763442993,
0.06844311207532883,
-0.2961980104446411,
-0.13240844011306763,
0.08175739645957947,
-0.02893221378326416,
-0.08256113529205322,
0.11516347527503967,
-0.04964732378721237,
0.11405403912067413,
0.2982913553714752,
-0.1196209043264389,
0.4271343946456909,
0.23824423551559448,
-0.3326147198677063,
-0.3080533444881439,
0.08407845348119736,
0.13963158428668976,
0.06843381375074387,
0.07607213407754898,
-0.007438779342919588,
-0.039090197533369064,
-0.22769269347190857,
-0.027234632521867752,
0.048570215702056885,
0.11673541367053986,
-0.022742420434951782,
-0.12307506799697876,
0.1394670009613037,
0.44258278608322144,
-0.1514054536819458,
-0.22032113373279572,
-0.43068981170654297,
-0.006018941756337881,
-0.11257179081439972,
0.0973433330655098,
0.014380241744220257,
-0.06877174228429794,
-0.2655028700828552,
0.30322399735450745,
0.07791201025247574,
-0.07367455959320068,
-0.029452791437506676,
-0.028444545343518257,
-0.33349063992500305,
-0.10896439105272293,
0.017633404582738876,
-0.07554518431425095,
0.07971871644258499,
0.06708332896232605,
0.29846489429473877,
-0.00844841543585062,
-0.07301825284957886,
-0.009217184968292713,
0.04329733923077583,
-0.013615145348012447,
-0.15533681213855743,
-0.03392637521028519,
-0.12293118238449097,
0.06486950814723969,
0.13353672623634338,
0.1264670193195343,
0.07664575427770615,
-0.2003229856491089,
0.12203052639961243,
-0.38622337579727173,
-0.11617836356163025,
-0.0345412939786911,
-0.05932628735899925,
-0.02795610949397087,
-0.024383651092648506,
-0.04999702423810959,
0.1120113953948021,
-0.15530803799629211,
0.35255348682403564,
0.13717147707939148,
0.09869785606861115,
0.16984662413597107,
0.23376542329788208,
0.03843303769826889,
-0.15472719073295593,
-0.3758825361728668,
-0.14970272779464722,
0.049903176724910736,
0.2947486340999603,
0.05022817477583885,
0.22262048721313477,
0.007080190349370241,
0.03727032244205475,
-0.1282753199338913,
0.00940981600433588,
0.2041812539100647,
-0.06964629143476486,
-0.17804285883903503,
-0.019253676757216454,
-0.2225353866815567,
-0.04511280357837677,
-0.10449976474046707,
0.5440935492515564,
0.03994648903608322,
0.0799955502152443
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.