PMID
int64 275k
40M
| DateCompleted
stringdate 1965-11-14 00:00:00
2025-02-28 00:00:00
⌀ | DateRevised
stringdate 2000-12-18 00:00:00
2025-02-28 00:00:00
| ISSN
stringlengths 9
9
⌀ | JournalTitle
stringlengths 2
239
| ArticleTitle
stringlengths 1
1.99k
⌀ | Authors
stringlengths 3
61.6k
⌀ | Language
stringclasses 47
values | Grants
stringlengths 11
10.6k
⌀ | PublicationTypes
stringlengths 4
259
| Chemicals
stringlengths 3
1.33k
⌀ | CitationSubset
stringclasses 2
values | ArticleIds
stringlengths 6
44.3k
| Abstract
stringlengths 1
16.7k
⌀ | MeshTerms
stringlengths 3
1.18k
⌀ | Keywords
stringlengths 1
17.2k
⌀ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
22,706,504 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | The American Psychiatric Publishing Textbook of Neuropsychiatry and Behavioral Neurosciences, Fifth Edition. | null | eng | null | Journal Article | null | null | 22706504, 99551, 10.1176/appi.ajp.2007.07101662 | null | null | null |
22,706,508 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | The Psychiatric Interview in Clinical Practice, Second Edition. | null | eng | null | Journal Article | null | null | 22706508, 99559, 10.1176/appi.ajp.2007.07101693 | null | null | null |
22,706,509 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | null | null | eng | null | Journal Article | null | null | 22706509, 99560, 10.1176/appi.ajp.2007.165.2.273 | null | null | null |
22,706,506 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Attachment Theory in Clinical Work With Children: Bridging the Gap Between Research and Practice. | null | eng | null | Journal Article | null | null | 22706506, 99555, 10.1176/appi.ajp.2007.07101692 | null | null | null |
22,706,507 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Psychotic Depression. | null | eng | null | Journal Article | null | null | 22706507, 99556, 10.1176/appi.ajp.2007.07111813 | null | null | null |
22,706,510 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | null | null | eng | null | Journal Article | null | null | 22706510, 99561, 10.1176/appi.ajp.2007.165.2.174 | null | null | null |
22,706,512 | 2013-03-06 | 2021-10-21 | 1435-4373 | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | Evaluation of three enzyme immunoassays and a loop-mediated isothermal amplification test for the laboratory diagnosis of Clostridium difficile infection. | Bruins M J, Verbeek E, Wallinga J A, Bruijnesteijn van Coppenraet L E S, Kuijper E J, Bloembergen P | eng | null | Comparative Study, Evaluation Study, Journal Article | Antigens, Bacterial, Bacterial Toxins, DNA, Bacterial | IM | 22706512, 10.1007/s10096-012-1658-y, 10871386, 17922780, 20702676, 22015321, 16441459, 12467772, 21084111, 20980562, 10878030, 21704273, 20610822, 20375230, 21697328, 10386368, 16517916, 19955275, 12560391, 21525213, 21725661, 9665986, 20032256, 8870764, 1401214, 19528959, 18434563, 21854871, 17609596, 19710274, 21628487, 19929972, 19900734 | The laboratory diagnosis of Clostridium difficile infection (CDI) consists of the detection of toxigenic Clostridium difficile, and/or its toxins A or B in stool preferably in a two-step algorithm. In a prospective study, we compared the performance of three toxin enzyme immunoassays (EIAs)-ImmunoCard Toxins A & B, Premier Toxins A & B and C. diff Quik Chek Complete, which combines a toxins test and a glutamate dehydrogenase (GDH) antigen EIA in one device -and the loop-mediated isothermal amplification assay Illumigene C. difficile. In total 986 stool samples were analyzed. Compared with toxigenic culture as the gold standard, sensitivities, specificities, PPV and NPV values of the toxin EIAs were 41.1-54.8 %, 98.9-100 %, 75.0-100 % and 95.5-96.5 % respectively, of the Illumigene assay 93.3 %, 99.7 %, 95.8 % and 99.5 %. Illumigene assays performed significantly better for non-014/020 PCR-ribotypes than for C. difficile isolates belonging to 014/020. Discrepant analysis of three culture-negative, but Illumigene-positive samples, revealed the presence of toxin genes using real-time PCRs. In addition to the GDH EIA (NPV of 99.8 %), the performance of Illumigene allows this test to be introduced as a first screening test for CDI- or as a confirmation test for GDH -positive samples, although the initial invalid Illumigene result of 4.4 % is a point of concern. | Antigens, Bacterial, Bacterial Toxins, Bacteriological Techniques, Clostridioides difficile, Clostridium Infections, DNA, Bacterial, Feces, Humans, Immunoenzyme Techniques, Nucleic Acid Amplification Techniques, Prospective Studies, Sensitivity and Specificity | null |
22,706,516 | 2014-01-24 | 2021-10-21 | 1869-1447 | Clinical neuroradiology | Subacute combined degeneration revealed by diffusion-weighted imaging: a case study. | Kim E Y, Lee S Y, Cha S H, Yi K S, Cho B S, Kang M H | eng | null | Case Reports, Letter | Vitamin B 12 | IM | 22706516, 10.1007/s00062-012-0141-6, 12221449, 9577479, 14872166, 17220583, 16908946, 10701640, 18653402, 15755562 | null | Diagnosis, Differential, Diffusion Magnetic Resonance Imaging, Humans, Injections, Intramuscular, Male, Middle Aged, Subacute Combined Degeneration, Treatment Outcome, Vitamin B 12, Vitamin B 12 Deficiency | null |
22,706,515 | 2013-03-06 | 2022-12-07 | 1435-4373 | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | Presence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in waste waters, Kinshasa, the Democratic Republic of the Congo. | De Boeck H, Lunguya O, Muyembe J-J, Glupczynski Y, Jacobs J | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Anti-Bacterial Agents, Waste Water, beta-Lactamases | IM | 22706515, 10.1007/s10096-012-1669-8, 18222958, 17855726, 16048717, 22608263, 20504993, 20885968, 19540725, 21478057 | Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are a major public health concern. We previously demonstrated the presence of ESBL-producing Enterobacteriaceae in sachet-packaged water bags sold in Kinshasa, the Democratic Republic of the Congo. In complement to the previous study, we aimed to assess the presence of ESBL-producing Enterobacteriaceae in waste waters in Kinshasa.Enterobacteriaceae isolates recovered from environmental water samples were screened and phenotypically confirmed as ESBL-producers by disk diffusion according to Clinical and Laboratory Standards Institute (CLSI) guidelines (CLSI M100-S21). Final identification to the species level and further antimicrobial susceptibility testing were carried out with MicroScan® NBC42 panels and the identification of bla (ESBL) coding genes was performed by a commercial multiplex ligation polymerase chain reaction (PCR) microarray (Check-Points CT 101, Wageningen, the Netherlands). Overall, 194 non-duplicate Enterobacteriaceae were recovered from several sewer and river sites in nine out of 24 municipalities of Kinshasa. Fourteen isolates (7.4 %) were confirmed as ESBL-producers, the main species being Enterobacter cloacae (46.6 %) and Klebsiella pneumoniae (40.0 %). Associated resistance to both aminoglycoside and fluoroquinolone antibiotics was observed in ten isolates; the remaining isolates showed co-resistance to either fluoroquinolone (n = 3) or to aminoglycoside (n = 1) alone. All but one isolate carried bla (CTX-M) genes belonging to the CTX-M-1 group. ESBL-producing Enterobacteriaceae are increasingly being reported from various sources in the community. The present results suggest that ESBL-producing Enterobacteriaceae are widespread in the environment in the community of Kinshasa. Cities in Central Africa should be added to the map of potentially ESBL-contaminated environments and highlight the need to reinforce safe water supply and public sanitation. | Anti-Bacterial Agents, Democratic Republic of the Congo, Drug Resistance, Bacterial, Enterobacteriaceae, Humans, Microarray Analysis, Microbial Sensitivity Tests, Polymerase Chain Reaction, Wastewater, beta-Lactamases | null |
22,706,514 | 2013-03-06 | 2021-10-21 | 1435-4373 | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | Evaluation of species-specific PCR, Bruker MS, VITEK MS and the VITEK 2 system for the identification of clinical Enterococcus isolates. | Fang H, Ohlsson A-K, Ullberg M, Ozenci V | eng | null | Journal Article | null | IM | 22706514, 10.1007/s10096-012-1667-x, 20433865, 15963275, 21656346, 20445331, 20164271, 8897165, 11320453, 368799, 19339079, 21767700, 11752353, 8501230, 9574718, 20477819, 7699051, 20636422, 21667269, 21283545, 15634977, 19756785, 18947320, 11923322, 19583519, 17368801, 11158155 | The purpose of this investigation was to compare the performance of species-specific polymerase chain reaction (PCR), matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) and phenotypic identification systems for the identification of Enterococcus species. A total of 132 clinical isolates were investigated by the following: (1) a multiplex real-time PCR assay targeting ddl Enterococcus faecium, ddl Enterococcus faecalis, vanC1 and vanC2/C3 genes, and a high-resolution melting (HRM) analysis of the groESL gene for the differentiation of Enterococcus casseliflavus and Enterococcus gallinarum; (2) Bruker MS; (3) VITEK MS; and (4) the VITEK 2 system. 16S rRNA gene sequencing was used as a reference method in the study. The 132 isolates were identified as 32 E. faecalis, 63 E. faecium, 16 E. casseliflavus and 21 E. gallinarum. The multiplex PCR, Bruker MS and VITEK MS were able to identify all the isolates correctly at the species level. The VITEK 2 system could identify 131/132 (99.2 %) and 121/132 (91.7 %) of the isolates at the genus and species levels, respectively. The HRM-groESL assay identified all (21/21) E. gallinarum isolates and 81.3 % (13/16) of the E. casseliflavus isolates. The PCR methods described in the present study are effective in identifying the enterococcal species. MALDI-TOF MS is a rapid, reliable and cost-effective identification technique for enterococci. The VITEK 2 system is less efficient at detecting non-faecalis and non-faecium Enterococcus species. | Bacterial Typing Techniques, Bacteriological Techniques, Costs and Cost Analysis, Enterococcus, Gram-Positive Bacterial Infections, Humans, Polymerase Chain Reaction, Sensitivity and Specificity, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | null |
22,706,517 | 2013-09-24 | 2021-10-21 | 1869-1447 | Clinical neuroradiology | Solitary spinal extradural plasmacytoma: a case report and literature review. | Tsutsumi S, Yasumoto Y, Ito M | eng | null | Case Reports, Journal Article, Review | null | IM | 22706517, 10.1007/s00062-012-0156-z, 6192351, 18299869, 20189464, 21498133, 14990813, 15009059, 8793437, 1111472, 11393129, 1520997, 7474406, 21325797, 11145465, 466107, 13717759, 16026744, 17905632 | Solitary spinal extradural plasmacytoma (SSEP) is a rare but distinct form of plasma cell disorder. The clinical picture and treatment of SSEP are reviewed using the seven previously reported cases. The three male and four female patients were aged 40-85 years. The location was cervical spine in one patient, cervicothoracic in one, thoracic in two, thoracolumbar in one, lumbar in one, and extensive involvement in one. Progressive paraparesis and sensory disturbance were the predominant symptoms. Neuroimaging showed a compressive extradural mass lesion in the dorsal spinal canal without findings of local bone destructive changes in all cases. Four of five patients who underwent decompressive surgical maneuver and tumor resection showed neurological improvement. Immunoglobulin (IgG) kappa subtype was the most predominant histological type, followed by IgD lambda and IgA kappa subtypes. SSEP should be included in the differential diagnosis of an extradural tumor located in the dorsal spinal canal without associated bony changes. Surgery may be effective for symptomatic relief. | Adult, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Plasmacytoma, Spinal Neoplasms, Tomography, X-Ray Computed, Treatment Outcome | null |
22,706,519 | 2012-10-24 | 2018-12-20 | 1477-9234 | Dalton transactions (Cambridge, England : 2003) | Charge-transfer guest interactions in luminescent MOFs: implications for solid-state temperature and environmental sensing. | Feng Patrick L, Leong Kirsty, Allendorf Mark D | eng | null | Journal Article, Research Support, U.S. Gov't, Non-P.H.S. | Aniline Compounds, Coordination Complexes, Dimethylamines, Metals, Solvents, N,N-diethylaniline, dimethylamine | IM | 22706519, 10.1039/c2dt30649b | One of the ongoing goals in the field of porous materials is the design and synthesis of materials that possess chemical structures amenable for use in sensing applications. We describe the preparation, luminescence characteristics, and environmental sensing properties of variants of the aluminum-based MOF [Al(OH)(O(2)C-C(10)H(6)-CO(2))](∞). Careful activation of the open framework complex, 1, yielded a dynamic structural transformation to a non-porous form, 2, that exhibited strong inter-linker interactions and red-shifted emission characteristics indicative of dimer formation. We also demonstrate the formation of highly luminescent ground-state charge-transfer (CT) complexes between 1 and the electron-donating amines dimethylamine (DMA) (1a), and N,N-diethylaniline (DEA) (1b), both of which exhibit dual-emission characteristics and a ratiometric luminescence response that is sensitive to temperature and solvent polarity. Steady-state and time-resolved measurements on 1a, 1b, and 2 indicate that the MOF structures stabilize ground-state CT interactions that are distinct from the weakly-bound exciplexes formed in comparable mixtures of purely organic components. The spectra for 1a and 1b also indicate different temperature dependencies that correspond to thermally-activated complex formation (ΔH(f) = +1.1 ± 0.2 kcal mol(-1)) in 1a and static quenching effects (ΔH(f) = -2.2 ± 0.3 kcal mol(-1)) in 1b. The addition of ethanol, isopropanol, toluene, or chloroform to suspensions of 1b indicate destabilization of the CT state with increasing solvent polarity, which suggests the generalized application of this or related materials in sensor applications. | Aniline Compounds, Coordination Complexes, Dimethylamines, Electrons, Metals, Porosity, Solvents, Spectrometry, Fluorescence, Temperature | null |
22,706,513 | 2013-03-06 | 2022-03-10 | 1435-4373 | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | Spread of an OmpK36-modified ST15 Klebsiella pneumoniae variant during an outbreak involving multiple carbapenem-resistant Enterobacteriaceae species and clones. | Novais A, Rodrigues C, Branquinho R, Antunes P, Grosso F, Boaventura L, Ribeiro G, Peixe L | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Bacterial Proteins, Carbapenems, DNA, Bacterial, OmpK36 protein, Klebsiella pneumoniae, Porins, beta-Lactamases | IM | 22706513, 10.1007/s10096-012-1665-z, 17913717, 18154531, 17479901, 20392607, 21450365, 20733047, 21303394, 19233898, 17185300, 19213695, 20881179, 18923005, 17005822, 22000347, 20034767, 20022220, 21605960, 10681329, 20537585, 14693513, 16436718, 3489731, 20660683, 20700614, 19995930, 20685754, 12096001, 18222954, 19502377, 22203588, 21422200, 16891499, 20528936 | We aim to characterise multiple ertapenem-resistant (ERT-R, n = 15) Enterobacteriaceae isolates identified as presumptive carbapenemase producers in a Portuguese hospital in a short period of time (March-July 2010). Antibiotic susceptibility patterns, β-lactamases, genetic relatedness [pulsed-field gel electrophoresis (PFGE), multi-locus sequence typing (MLST)], plasmid content and major enterobacterial porins were investigated. Ertapenem resistance was associated with deficiencies in major porins and, in some cases, extended-spectrum β-lactamase (ESBL) or AmpC β-lactamase production among outbreak and non-outbreak clones. Most isolates (n = 8) corresponded to two ERT-R Klebsiella pneumoniae ST15 PFGE-types: (i) a sporadic variant (Kp-A-ERT, n = 1) presenting a premature stop codon in ompK36 and (ii) an epidemic variant (Kp-B-ERT, n = 7) exhibiting a new OmpK36 porin variant, which differed additionally in plasmid and antibiotic susceptibility profiles. ST14 (n = 1) and ST45 (n = 1) K. pneumoniae, ST131 (n = 1) and ST354 (n = 1) Escherichia coli, Enterobacter asburiae (n = 1), Enterobacter cloacae (n = 1) and Enterobacter aerogenes (n = 1) ERT-R clones were also sporadically detected. Porin changes in these isolates included non-sense mutations [ompK35, ompK36, ompF; minimum inhibitory concentration (MIC) = 4-32 mg/l], IS-mediated porin disruptions (ompK36, ompC; MIC = 12->32 mg/l) or alterations in the L3 loop (ompK36; MIC = 4-16 mg/l). We describe, for the first time in Portugal, the simultaneous emergence of multiple ERT-R Enterobacteriaceae species and clones in a short period of time. Moreover, our results support that a CTX-M-15-producing ST15 K. pneumoniae with an OmpK36-modified porin might successfully spread in the nosocomial setting. | Bacterial Proteins, Carbapenems, DNA Fingerprinting, DNA, Bacterial, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Enterobacteriaceae, Enterobacteriaceae Infections, Hospitals, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Multilocus Sequence Typing, Plasmids, Porins, Portugal, Sequence Analysis, DNA, beta-Lactam Resistance, beta-Lactamases | null |
22,706,518 | 2013-03-18 | 2015-11-19 | 1461-7285 | Journal of psychopharmacology (Oxford, England) | Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment. | Wang Ying, Jia Yanbin, Chen Xinjian, Ling Xueying, Liu Sirun, Xu Guiyun, Huang Li | eng | null | Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't | Antidepressive Agents, Thiophenes, Aspartic Acid, Duloxetine Hydrochloride, N-acetylaspartate, Creatine, Choline, Hydrocortisone | IM | 22706518, 0269881112450781, 10.1177/0269881112450781 | An excess of glucocorticoids has been associated with hippocampal pathology in major depressive disorder (MDD). However, the relationships between depression, hippocampal structure and function, and cortisol levels are unclear, and the effects of antidepressant treatment on the measures are not well studied. For this study, 26 first-episode, treatment-naive, non-late-life adult depressed patients and 13 healthy controls were enrolled. Subjects underwent proton magnetic resonance spectroscopy ((1)H MRS) to obtain metabolite levels from the bilateral hippocampus. Patients with MDD were treated with serotonergic-noradrenergic reuptake inhibitor duloxetine for 12 weeks. After the 12-week period, all subjects with MDD underwent (1)H MRS again. Morning serum cortisol levels also were measured both before and after antidepressant treatment. Comparison of baseline values indicated that there were no significant differences in any of the metabolite ratios (N-acetyl aspartate/creatine (NAA/Cr) and choline (Cho)/Cr) in the bilateral hippocampus. After treatment, NAA/Cr ratios increased significantly in the right hippocampus compared with pre-treatment values. There was no correlation between morning serum cortisol levels and bilateral hippocampal NAA/Cr or Cho/Cr in patients with MDD. These findings suggest that there are unaltered hippocampal metabolites in the early stage of MDD. Antidepressant treatment may affect hippocampal NAA levels in patients with MDD. In addition, the results do not support cortisol-mediated hippocampal neurotoxicity as the major etiological mechanism. | Adolescent, Adult, Antidepressive Agents, Aspartic Acid, Case-Control Studies, Choline, Creatine, Depressive Disorder, Major, Duloxetine Hydrochloride, Female, Hippocampus, Humans, Hydrocortisone, Magnetic Resonance Spectroscopy, Male, Middle Aged, Thiophenes, Young Adult | null |
22,706,520 | 2012-11-09 | 2018-12-01 | 2040-3372 | Nanoscale | Synthesis of PEGylated fullerene-5-fluorouracil conjugates to enhance the antitumor effect of 5-fluorouracil. | Dou Zengpei, Xu Yingying, Sun Hongfang, Liu Yuanfang | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antineoplastic Agents, Drug Carriers, Fullerenes, Polyethylene Glycols, Fluorouracil | IM | 22706520, 10.1039/c2nr30380a | Many drugs have been delivered by different types of nanoscale vehicles to enhance their therapeutic efficacy. 5-Fluorouracil (5FU) is a widely used antitumor drug, however its bioavailability still needs to be improved. Herein we synthesized a polyethylene glycol monomethylether-C(60)-5FU conjugate (mPEG-C(60)-5FU) and evaluated its antitumor efficacy in vitro. The results show that the inhibition abilities of mPEG-C(60)-5FU to the human breast cancer cell line MCF-7 and the human gastric carcinoma cell line BGC-823 are significantly higher than that of 5FU. The conjugate has good stability in murine serum for at least 24 h. Moreover, the PEGylated fullerene (mPEG-C(60)) vehicle is non-toxic to MCF-7 cells. These results demonstrate that mPEG-C(60) is an efficient vehicle for the delivery of 5FU. | Antineoplastic Agents, Cell Line, Tumor, Cell Proliferation, Drug Carriers, Fluorouracil, Fullerenes, Humans, Nanostructures, Polyethylene Glycols | null |
22,706,521 | 2013-05-01 | 2018-12-01 | 1873-6750 | Environment international | Impact of human activities on the geomagnetic field of Antarctica: a high resolution aeromagnetic survey over Mario Zucchelli Station. | Armadillo E, Bozzo E, Gambetta M, Rizzello D | eng | null | Journal Article | null | IM | 22706521, S0160-4120(12)00117-1, 10.1016/j.envint.2012.05.005 | Environmental protection of Antarctica is a fundamental principle of the Antarctic Treaty. Impact assessment and significance evaluation are due for every human activity on the remote continent. While chemical and biological contaminations are widely studied, very little is known about the electromagnetic pollution levels. In this frame, we have evaluated the significance of the impact of Mario Zucchelli Antarctic Station (Northern Victoria Land) on the local geomagnetic field. We have flown a high resolution aeromagnetic survey in drape mode at 320m over the Station, covering an area of 2km(2). The regional and the local field have been separated by a third order polynomial fitting. After the identification of the anthropic magnetic anomaly due to the Station, we have estimated the magnetic field at the ground level by downward continuation with an original inversion scheme regularized by a minimum gradient support functional to avoid high frequency noise effects. The resulting anthropic static magnetic field at ground extends up to 650m far from the Station and reaches a maximum peak to peak value of about 2800nT. This anthropic magnetic anomaly may interact with biological systems, raising the necessity to evaluate the significance of the static magnetic impact of human installations in order to protect the electromagnetic environment and the biota of Antarctica. | Antarctic Regions, Environment, Environmental Monitoring, Environmental Pollution, Human Activities, Humans, Magnetic Fields | null |
22,706,522 | 2013-01-22 | 2016-05-11 | 1868-6982 | Journal of hepato-biliary-pancreatic sciences | Therapeutic strategies for hepatic metastasis of colorectal cancer: overview. | Sugihara Kenichi, Uetake Hiroyuki | eng | null | Journal Article, Review | null | IM | 22706522, 10.1007/s00534-012-0524-8 | To determine the treatment strategy for hepatic metastases of colorectal cancer, it is important to take into account whether metastases are still localized in the liver, or whether the tumor has metastasized throughout the body. For liver-limited metastasis, hepatectomy is the therapeutic strategy that offers the best prospect of improving a patient's prognosis if the case is deemed resectable. In cases when surgery is not indicated for hepatic metastases of colorectal cancer, chemotherapy is the first-choice treatment. Chemotherapy for colorectal cancer has made vast strides in recent years through advances such as the development of molecular targeted drugs. In cases where chemotherapy is effective and surgical resection becomes possible (conversion chemotherapy), the long-term prognosis may be good. The value of preoperative chemotherapy in resectable cases (neoadjuvant chemotherapy) has also been reported. The improvement in prognosis achieved by eradicating tiny latent metastases is important in conversion therapy, as well as in neoadjuvant chemotherapy. It will be important to achieve further improvements in the prognoses of patients with hepatic metastases of colorectal cancer through a combination of advances in diagnostic imaging, improvements in surgical techniques, and more effective chemotherapy treatments. | Antineoplastic Combined Chemotherapy Protocols, Chemotherapy, Adjuvant, Colorectal Neoplasms, Hepatectomy, Humans, Liver Neoplasms, Neoadjuvant Therapy | null |
22,706,523 | 2012-10-19 | 2012-07-03 | 1463-9084 | Physical chemistry chemical physics : PCCP | Bright photoluminescent hybrid mesostructured silica nanoparticles. | Miletto Ivana, Bottinelli Emanuela, Caputo Giuseppe, Coluccia Salvatore, Gianotti Enrica | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Carbocyanines, Fluorescent Dyes, Silicon Dioxide | IM | 22706523, 10.1039/c2cp40975e | Bright photoluminescent mesostructured silica nanoparticles were synthesized by the incorporation of fluorescent cyanine dyes into the channels of MCM-41 mesoporous silica. Cyanine molecules were introduced into MCM-41 nanoparticles by physical adsorption and covalent grafting. Several photoluminescent nanoparticles with different organic loadings have been synthesized and characterized by X-ray powder diffraction, high resolution transmission electron microscopy and nitrogen physisorption porosimetry. A detailed photoluminescence study with the analysis of fluorescence lifetimes was carried out to elucidate the cyanine molecules distribution within the pores of MCM-41 nanoparticles and the influence of the encapsulation on the photoemission properties of the guests. The results show that highly stable photoluminescent hybrid materials with interesting potential applications as photoluminescent probes for diagnostics and imaging can be prepared by both methods. | Adsorption, Carbocyanines, Fluorescent Dyes, Luminescent Measurements, Molecular Structure, Nanoparticles, Particle Size, Porosity, Powder Diffraction, Silicon Dioxide, Surface Properties | null |
22,706,524 | 2013-03-12 | 2012-10-18 | 1572-9699 | Antonie van Leeuwenhoek | Lysobacter thermophilus sp. nov., isolated from a geothermal soil sample in Tengchong, south-west China. | Wei Da-Qiao, Yu Tian-Tian, Yao Ji-Cheng, Zhou En-Min, Song Zhao-Qi, Yin Yi-Rui, Ming Hong, Tang Shu-Kun, Li Wen-Jun | eng | null | Journal Article, Research Support, Non-U.S. Gov't | DNA, Bacterial, DNA, Ribosomal, Fatty Acids, Phospholipids, Pigments, Biological, Quinones, RNA, Ribosomal, 16S | IM | 22706524, 10.1007/s10482-012-9761-8 | A Gram-negative and aerobic bacterium, designated YIM 77875(T), was isolated from a geothermal soil sample collected at Rehai National Park, Tengchong, Yunnan Province, south-west China. Bacterial growth occurred from 37 to 65 °C (optimum 50 °C), pH 6.0-8.0 (optimum pH 7.0) and 0-1 % NaCl (w/v). Cells were rod-shaped and colonies were convex, circular, smooth, yellow and non-transparent. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that strain YIM 77875(T) belongs to the genus Lysobacter. The 16S rRNA gene sequence similarity values between strain YIM 77875(T) and other species of the genus Lysobacter were all below 94.7 %. The polar lipids of strain YIM 77875(T) were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine and five unknown phospholipids. The predominant respiratory quinone was Q-8 and the G+C content was 68.8 mol%. Major fatty acids were iso-C(16:0), iso-C(15:0) and iso-C(11:0). On the basis of the morphological and chemotaxonomic characteristics, as well as genotypic data, strain YIM 77875(T) represents a novel species, Lysobacter thermophilus sp. nov., in the genus Lysobacter. The type strain is YIM 77875(T) (CCTCC AB 2012064(T) = KCTC 32020(T)). | Aerobiosis, Bacterial Typing Techniques, Base Composition, China, Cluster Analysis, DNA, Bacterial, DNA, Ribosomal, Fatty Acids, Hydrogen-Ion Concentration, Lysobacter, Molecular Sequence Data, Phospholipids, Phylogeny, Pigments, Biological, Quinones, RNA, Ribosomal, 16S, Sequence Analysis, DNA, Soil Microbiology, Temperature | null |
22,706,525 | 2012-10-18 | 2022-03-16 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Granulomatous lymphadenitis. | Asano Shigeyuki | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | null | IM | 22706525, DN/JST.JSTAGE/jslrt/52.1, 10.3960/jslrt.52.1 | In this review, representative types of granulomatous lymphadenitis (GLA) are described. GLA can be classified as noninfectious GLA and infectious GLA. Noninfectious GLA includes sarcoidosis and sarcoid-like reaction. The cause of sarcoidosis remains unknown, but it has good prognosis. Sarcoid-like reaction, which is considered to be a biological defense mechanism, is observed in regional lymph nodes with many underlying diseases. Infectious GLA can be classified as suppurative lymphadenitis (LA) and nonsuppurative LA. Suppurative LA generally shows follicular hyperplasia and sinus histiocytosis in the early phase. In tularemia and cat scratch disease, monocytoid B lymphocytes (MBLs) with T cells and macrophages contribute to the formation of granuloma. However, none of the epithelioid cell granulomas of Yersinia LA contains MBLs like in cat scratch disease. In addition, almost all have a central abscess in granulomas induced by Gram-negative bacteria. In terms of the lymph nodes, tularemia and cat scratch disease are apt to affect the axillary and cervical regions while Yersinia LA affects the mesenteric lymph node. Nonsuppurative LA includes tuberculosis and BCG-histiocytosis. These are induced by delayed allergic reaction of M. tuberculosis. Tuberculosis LA mainly appears in the cervical lymph node. Organisms are histologically detected by Ziehl-Neelsen staining in the necrotic area. Toxoplasmosis is also a nonsuppurative protozoan infection (Toxoplasma gondii). In toxoplasma LA, MBLs can also be seen, but round and organized, well-formed granulomas are not found in this disease. Furthermore, necrosis is not induced and there are no accompanying neutrophils, eosinophils and fibrosis. GLA described above is associated with characteristic histological findings. An accurate pathological diagnosis using the above findings can lead to precise treatment. | Animals, Cat-Scratch Disease, Gram-Negative Bacterial Infections, Granuloma, Humans, Lymph Nodes, Sarcoidosis | null |
22,706,526 | 2012-10-18 | 2022-12-22 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | CADM1/TSLC1 is a novel cell surface marker for adult T-cell leukemia/lymphoma. | Nakahata Shingo, Morishita Kazuhiro | eng | null | Journal Article, Review | Biomarkers, Tumor, CADM1 protein, human, Cell Adhesion Molecule-1, Cell Adhesion Molecules, Immunoglobulins, Tumor Suppressor Proteins | IM | 22706526, DN/JST.JSTAGE/jslrt/52.17, 10.3960/jslrt.52.17 | CADM1/TSLC1 (Cell adhesion molecule 1/Tumor suppressor in lung cancer 1) is a cell adhesion molecule that was originally identified as a tumor suppressor in lung cancer. CADM1/TSLC1 expression is reduced in a variety of cancers via promoter methylation, and this reduction is associated with poor prognosis and enhanced metastatic potential. In contrast, we observed that CADM1/TSLC1 is highly and ectopically expressed in all primary adult T-cell leukemia/lymphoma (ATLL) cells and in most human T-cell leukemia virus type (HTLV)-1-infected T-cell and ATLL cell lines. No expression, however, was detected in CD4 | Biomarkers, Tumor, CD4-Positive T-Lymphocytes, Cell Adhesion, Cell Adhesion Molecule-1, Cell Adhesion Molecules, Cell Line, Tumor, Gene Expression Regulation, Leukemic, Human T-lymphotropic virus 1, Humans, Immunoglobulins, Leukemia-Lymphoma, Adult T-Cell, Tumor Suppressor Proteins | null |
22,706,528 | 2012-10-18 | 2021-12-03 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Tuberculous meningoencephalitis in a patient with hairy cell leukemia in complete remission. | Girardi K, Paviglianiti A, Cirillo M, Bianchi A, Gherardi G, Annibali O, Cerchiara E, Marchesi F, Tomarchio V, Miglio C, Tirindelli Mc, Onetti Muda A, Avvisati G | eng | null | Case Reports, Journal Article | Antineoplastic Agents, Cladribine | IM | 22706528, DN/JST.JSTAGE/jslrt/52.31, 10.3960/jslrt.52.31 | Tuberculous meningoencephalitis is a rare disease associated with high morbidity and mortality. We report a patient with hairy cell leukemia in complete remission who, after a single cycle of chemotherapy with cladribine, presented fever and neurological deficits. Laboratory diagnosis of tuberculous meningoencephalitis was made by polymerase chain reaction testing for Mycobacterium tuberculosis in cerebrospinal fluid. Despite the prompt institution of antitubercular-therapy, patient's general condition did not improve and he died. Mycobacterial infection should be considered in patients with intra-cranial lesions, affected by hematological malignancies and persistent immunosuppression. | Antineoplastic Agents, Cladribine, Fatal Outcome, Humans, Immunosuppression Therapy, Leukemia, Hairy Cell, Male, Meningoencephalitis, Middle Aged, Tuberculosis, Meningeal | null |
22,706,527 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Blastic plasmacytoid dendritic cell neoplasm : report of two cases. | Tsunoda Kanako, Satoh Takashi, Akasaka Kiyomi, Ishikawa Yuichi, Ishida Yoji, Masuda Tomoyuki, Akasaka Toshihide | eng | null | Case Reports, Journal Article | Antigens, CD | IM | 22706527, DN/JST.JSTAGE/jslrt/52.23, 10.3960/jslrt.52.23 | Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive tumor derived from the precursor of plasmacytoid dendritic cells. We describe two cases of BPDCN. In case 1, the patient presented with multiple erythema on the trunk and arms. Histopathology of a skin biopsy specimen and immunohistochemistry demonstrated that the tumor cells were small to medium-sized with a blastoid morphology and positive for CD4, CD56, CD123 and T-cell leukemia-1 (TCL-1). In case 2, the patient presented with a solitary skin nodule and rapidly developed involvement of the bone marrow and peripheral blood. Although immunohistochemistry of the infiltrating tumor cells demonstrated positivity for CD4, CD56, CD123 and TCL-1, the cells were large with a distinct nucleolus, and different from those of typical BPDCN. The atypical morphological features of BPDCN may be diagnostically problematic, and should therefore be recognized correctly. | Aged, Aged, 80 and over, Antigens, CD, Dendritic Cells, Histiocytic Disorders, Malignant, Humans, Male, Plasma Cells, Skin Neoplasms | null |
22,706,530 | 2012-10-18 | 2022-04-19 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Orbital MALT lymphoma, abdominal hodgkin lymphoma, and systemic diffuse large B-cell lymphoma develop sequentially in one patient. | Matsuo Toshihiko, Ichimura Kouichi, Shinagawa Katsuji | eng | null | Case Reports, Journal Article | null | IM | 22706530, DN/JST.JSTAGE/jslrt/52.41, 10.3960/jslrt.52.41 | In February 2002, a 42-year-old woman developed ocular adnexal extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT), MALT lymphoma, in the bilateral orbits involving lacrimal glands. She underwent 30 Gy external beam irradiation to the orbital lesions on both sides. She was well until November 2008 when she developed abdominal lymphadenopathy and transabdominal excisional biopsy showed mixed cellularity classical Hodgkin lymphoma at stage II. She underwent standard combination chemotherapy. In July 2010, she developed systemic lymphadenopathy and was diagnosed with diffuse large B-cell lymphoma (DLBCL) by cervical lymph node biopsy. She underwent rituximab monotherapy and finally allogeneic hematopoietic stem cell transplantation in October 2010, but died of renal failure in February 2011. Amplification by polymerase chain reaction of the immunoglobulin heavy chain gene gave rise to dominant discrete fragments of the same size between the orbital lesion with MALT lymphoma in 2002 and the cervical lymph node lesion with DLBCL in 2010. The sequential development of MALT lymphoma, Hodgkin lymphoma, and DLBCL in the long-term course of this patient suggests the common origin of the neoplastic cells, changing their pathological faces in response to irradiation and combination chemotherapy. | Abdominal Neoplasms, Adult, Female, Hodgkin Disease, Humans, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Large B-Cell, Diffuse, Neoplasms, Second Primary, Orbital Neoplasms | null |
22,706,531 | 2012-10-18 | 2022-12-22 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Ocular adnexal IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. | Sato Yasuharu, Ohshima Koh-Ichi, Takata Katsuyoshi, Huang Xingang, Cui Wei, Ohno Kyotaro, Yoshino Tadashi | eng | null | Case Reports, Journal Article | Immunoglobulin G, Neoplasm Proteins | IM | 22706531, DN/JST.JSTAGE/jslrt/52.51, 10.3960/jslrt.52.51 | IgG4-related disease is a recently proposed clinical entity with several unique clinicopathological features. A chronic inflammatory state with marked fibrosis, which can often be mistaken for malignancy, especially by clinical imaging analyses, unifies these features. In the present report, we describe a case of IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. The patient was a 55-year-old male who was being followed for right orbital tumor over 1.5 years. The lesion had recently increased in size, so a biopsy was performed. Histologically, the lesion was consistent with IgG4-related disease ; however, IgG4 | Biopsy, Dacryocystitis, Diagnosis, Differential, Eye Neoplasms, Gene Expression Regulation, Neoplastic, Humans, Immunoglobulin G, Lymphoma, B-Cell, Marginal Zone, Male, Middle Aged, Mikulicz' Disease, Neoplasm Proteins | null |
22,706,529 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Lymph node infarction in classical Hodgkin's lymphoma. | Mori Eiichiro, Enomoto Yasunori, Nakamine Hirokazu, Kasai Takahiko, Takeda Maiko, Takano Masato, Morita Kouhei, Koizumi Toshizo, Nonomura Akitaka | eng | null | Case Reports, Journal Article | Biomarkers, Tumor | IM | 22706529, DN/JST.JSTAGE/jslrt/52.35, 10.3960/jslrt.52.35 | Among lymphoproliferative disorders, lymph node infarction appears to be most frequently seen in diffuse large B-cell lymphoma, followed by follicular lymphoma, with other types being rare. We experienced one such case, classical Hodgkin's lymphoma (cHL) associated with lymph node infarction, in which Reed-Sternberg (RS) cells were positive for CD15, CD30, fascin, PAX-5, p53, latent membrane protein-1 (LMP-1), Bcl-2, and EBV-encoded small non-polyadenylated RNAs. Furthermore, RS cells in the infarcted area were still positive for CD30, fascin, p53, and Bcl-2. For definitive diagnosis of nodal lymphomas including Hodgkin's lymphoma, identification of the effacement of normal nodal architecture is essential. Although this could not be evaluated in our case because of predominant reactive follicular hyperplasia with interfollicular distribution of RS cells, the presence of large cells with RS cell-related molecules together with the distorted distribution of cCD3-positive cells and CD20-positive cells led us to make a definitive diagnosis of cHL. It is, therefore, considered that immunohistochemical evaluation of the infarcted lymph node is, at least on some occasions, still informative for more accurate diagnosis of lymphoid neoplasia. Hodgkin's lymphoma should also be considered when one encounters lymph node infarction. | Aged, Biomarkers, Tumor, Female, Hodgkin Disease, Humans, Infarction, Lymph Nodes, Reed-Sternberg Cells | null |
22,706,532 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Rheumatoid lymphadenopathy with abundant IgG4(+) plasma cells : a case mimicking IgG4-related disease. | Asano Naoko, Sato Yasuharu | eng | null | Case Reports, Journal Article | Immunoglobulin G | IM | 22706532, DN/JST.JSTAGE/jslrt/52.57, 10.3960/jslrt.52.57 | Immunoglobulin (Ig) G4-related disease is a recently confirmed clinical entity with several unique clinicopathological features. Here we report a case of rheumatoid lymphadenopathy mimicking IgG4-related disease. The patient was a 63-year-old woman who had been treated for rheumatoid arthritis (RA) for six years. The patient noted cervical lymphadenopathy. Upon radiological examination, systemic lymphadenopathy was detected, and enlarged right brachial lymph node biopsy was performed. Histologically, the lymph node showed marked follicular hyperplasia and interfollicular plasmacytosis without eosinophil infiltration. Although the histological findings were compatible with rheumatoid lymphadenopathy, numerous plasma cells were IgG4(+) (IgG4(+)/IgG(+) plasma cell ratio > 50%). However, laboratory findings revealed elevation of C-reactive protein level, polyclonal hyper-γ-globulinemia, anemia, and hypoalbuminemia. These findings were compatible with hyper-interleukin (IL)-6 syndrome, namely, RA. It is known that hyper-IL-6 syndromes, such as multicentric Castleman's disease, RA, and other autoimmune diseases, fulfill the histological diagnostic criteria for IgG4-related disease. Therefore, hyper-IL-6 syndromes and IgG4-related disease cannot be differentially diagnosed by immunohistochemical staining alone. In conclusion, rheumatoid lymphadenopathy sometimes occurs with abundant IgG4(+) plasma cells, which is required for the differential diagnosis of IgG4-related disease. | Diagnosis, Differential, Female, Humans, Hypergammaglobulinemia, Immunoglobulin G, Lymphatic Diseases, Plasma Cells, Rheumatic Diseases, Syndrome | null |
22,706,538 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Letter from the editor. | Cheson Bruce D | eng | null | Letter | null | IM | 22706538 | null | Humans, Neoplasms, Physician-Patient Relations | null |
22,706,535 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Epstein-Barr virus-negative classical Hodgkin's lymphoma in a patient with T-cell prolymphocytic leukemia treated with fludarabine. | Tsuji Takahiro, Yamasaki Hiroshi, Arima Nobuyuki, Niino Daisuke, Ohshima Koichi, Tsuda Hiroyuki | eng | null | Case Reports, Letter | Antineoplastic Agents, Vidarabine, fludarabine | IM | 22706535, DN/JST.JSTAGE/jslrt/52.71, 10.3960/jslrt.52.71 | null | Antineoplastic Agents, Female, Herpesvirus 4, Human, Hodgkin Disease, Humans, Leukemia, Prolymphocytic, T-Cell, Middle Aged, Neoplasms, Second Primary, Vidarabine | null |
22,706,533 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Prediction of progression from refractory cytopenia with unilineage dysplasia by analysis of bone marrow blast cell composition. | Oka Satoko, Muroi Kazuo, Fujiwara Shin-Ichiro, Oh Iekuni, Matsuyama Tomohiro, Ohmine Ken, Suzuki Takahiro, Ozaki Katsutoshi, Mori Masaki, Nagai Tadashi, Ozawa Keiya, Hanafusa Toshiaki | eng | null | Journal Article | Antigens, CD, Antigens, Differentiation, Myelomonocytic, CD33 protein, human, Sialic Acid Binding Ig-like Lectin 3, Neprilysin | IM | 22706533, DN/JST.JSTAGE/jslrt/52.63, 10.3960/jslrt.52.63 | A retrospective analysis of 71 patients newly diagnosed with refractory cytopenia with unilineage dysplasia (RCUD) revealed that 12 developed refractory anemia with an excess of blasts or acute myeloblastic leukemia. Before the diagnosis of RCUD was made, phenotypes of cells in the bone marrow (BM) blast region were analyzed using flow cytometry. Patients with RCUD were divided into two groups ; those with no progression (Group A) and those with disease progression later on (Group B). The cell composition in the BM blast region differed significantly between the groups : Group A showed higher percentages of B lymphoid cells but lower percentages of myeloid cells. A cut-off value of 20 for the CD33/CD10 ratio in the BM blast region clearly separated Group A from Group B. These results suggest that cell composition in the BM blast region evaluated by flow cytometry may indicate the progression of RCUD. | Adult, Aged, Aged, 80 and over, Anemia, Refractory, with Excess of Blasts, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Blast Crisis, Disease Progression, Female, Follow-Up Studies, Humans, Leukemia, Myeloid, Acute, Male, Middle Aged, Myeloid Progenitor Cells, Neprilysin, Precursor Cells, B-Lymphoid, Sialic Acid Binding Ig-like Lectin 3 | null |
22,706,537 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Autologous hematopoietic recovery with aberrant antigen expression after allogeneic bone marrow transplantation. | Kobayashi Hiroyuki, Matsuyama Tomohiro, Oka Satoko, Fujiwara Shin-Ichiro, Oh Iekuni, Suzuki Takahiro, Ozaki Katsutoshi, Mori Masaki, Nagai Tadashi, Ozawa Keiya, Muroi Kazuo | eng | null | Case Reports, Letter | Antigens, Differentiation | IM | 22706537, DN/JST.JSTAGE/jslrt/52.81, 10.3960/jslrt.52.81 | null | Antigens, Differentiation, Bone Marrow Transplantation, Female, Gene Expression Regulation, Hematopoiesis, Humans, Leukemia, Myeloid, Acute, Middle Aged, Recovery of Function, Transplantation, Homologous | null |
22,706,534 | 2012-10-18 | 2019-11-12 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Hepatitis B reactivation in a multiple myeloma patient with resolved hepatitis B infection during bortezomib therapy : case report. | Tanaka Hiroaki, Sakuma Ikuo, Hashimoto Shinichiro, Takeda Yusuke, Sakai Shio, Takagi Toshiyuki, Shimura Takanori, Nakaseko Chiaki | eng | null | Case Reports, Journal Article | Antineoplastic Agents, Boronic Acids, DNA, Viral, Pyrazines, Bortezomib | IM | 22706534, DN/JST.JSTAGE/jslrt/52.67, 10.3960/jslrt.52.67 | It has recently been reported that hepatitis B virus (HBV) reactivation in patients with hepatitis B surface antigen (HBsAg)-negative lymphoma during or after cytotoxic therapy occurs after the use of rituximab and stem cell transplantation for hematologic malignancies. However, clinical data on HBV reactivation in multiple myeloma patients have not been extensively reported. This is the first reported case of HBV reactivation in an HBsAg-negative myeloma patient treated with bortezomib (BOR) as salvage therapy and not stem cell transplantation. By closely monitoring HBV-DNA and early administration of entecavir, severe hepatitis was avoided and BOR therapy was continued. We suggest the importance of close monitoring of HBV-DNA for transplant-ineligible myeloma patients treated with BOR as salvage therapy. | Aged, Antineoplastic Agents, Boronic Acids, Bortezomib, DNA, Viral, Hepatitis B, Hepatitis B virus, Humans, Male, Multiple Myeloma, Pyrazines, Virus Activation | null |
22,706,539 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | The role of the fallopian tube in ovarian cancer. | Tone Alicia A, Salvador Shannon, Finlayson Sarah J, Tinker Anna V, Kwon Janice S, Lee Cheng-Han, Cohen Trevor, Ehlen Tom, Lee Marette, Carey Mark S, Heywood Mark, Pike Judith, Hoskins Paul J, Stuart Gavin C, Swenerton Kenneth D, Huntsman David G, Gilks C Blake, Miller Dianne M, McAlpine Jessica N | eng | null | Journal Article, Review | null | IM | 22706539 | High-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian cancer. Research over the past decade has strongly suggested that "ovarian" HGSC arises in the epithelium of the distal fallopian tube, with serous tubal intraepithelial carcinomas (STICs) being detected in 5-10% of BRCA1/2 mutation carriers undergoing risk-reducing surgery and up to 60% of unselected women with pelvic HGSC. The natural history, clinical significance, and prevalence of STICs in the general population (ie, women without cancer and not at an increased genetic risk) are incompletely understood, but anecdotal evidence suggests that these lesions have the ability to shed cells with metastatic potential into the peritoneal cavity very early on. Removal of the fallopian tube (salpingectomy) in both the average and high-risk populations could therefore prevent HGSC, by eliminating the site of initiation and interrupting spread of potentially cancerous cells to the ovarian/peritoneal surfaces. Salpingectomy may also reduce the incidence of the 2 next most common subtypes, endometrioid and clear cell carcinoma, by blocking the passageway linking the lower genital tract to the peritoneal cavity that enables ascension of endometrium and factors that induce local inflammation. The implementation of salpingectomy therefore promises to significantly impact ovarian cancer incidence and outcomes. | Cell Transformation, Neoplastic, Cystadenocarcinoma, Serous, Early Detection of Cancer, Fallopian Tube Neoplasms, Fallopian Tubes, Female, Humans, Neoplasm Grading, Ovarian Neoplasms | null |
22,706,536 | 2012-10-18 | 2019-12-10 | 1880-9952 | Journal of clinical and experimental hematopathology : JCEH | Retrospective study of the utility of FLIPI/FLIPI-2 for follicular lymphoma patients treated with R-CHOP. | Numata Ayumi, Tomita Naoto, Fujimaki Katsumichi, Tanaka Masatsugu, Hashimoto Chizuko, Oshima Rika, Matsumoto Kenji, Matsuura Shiro, Yamamoto Wataru, Motomura Shigeki, Ishigatsubo Yoshiaki | eng | null | Clinical Trial, Comparative Study, Letter | Antibodies, Monoclonal, Murine-Derived, R-CHOP protocol, Rituximab, Vincristine, Doxorubicin, Cyclophosphamide, Prednisone | IM | 22706536, DN/JST.JSTAGE/jslrt/52.77, 10.3960/jslrt.52.77 | null | Adult, Aged, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols, Cyclophosphamide, Disease-Free Survival, Doxorubicin, Female, Humans, Lymphoma, Follicular, Male, Middle Aged, Prednisone, Retrospective Studies, Rituximab, Survival Rate, Vincristine | null |
22,706,540 | 2015-04-09 | 2018-12-01 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Comprehensive overview of axitinib development in solid malignancies: focus on metastatic renal cell carcinoma. | Carmichael Courtney, Lau Clayton, Josephson David Y, Pal Sumanta K | eng | K12 2K12CA001727-16A1 (NCI NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Review | Antineoplastic Agents, Imidazoles, Indazoles, Protein Kinase Inhibitors, Axitinib | IM | 22706540 | The landscape of treatment for metastatic renal cell carcinoma (mRCC) continues to evolve. Although several new drugs have been approved for the treatment of this disease in recent years, mRCC remains incurable. Thus, the search continues for new effective therapies. One such novel compound is axitinib (Inlyta, Pfizer), a potent vascular endothelial growth factor receptor tyrosine kinase inhibitor. Following phase I testing in advanced solid tumors (where hypertension, stomatitis, and diarrhea were the dose-limiting toxicities), use of axitinib has been further developed through phase II testing in thyroid, breast, lung, and renal cancers. Recently, the phase III AXIS (Axitinib [AG 013736] as Second Line Therapy for Metastatic Renal Cell Cancer) trial demonstrated an improvement in progression-free survival for patients with mRCC who were treated with axitinib versus sorafenib (Nexavar, Bayer) as second-line therapy. This article describes the preclinical and clinical evolution of axitinib, with an emphasis on its development and role in mRCC. | Animals, Antineoplastic Agents, Axitinib, Carcinoma, Renal Cell, Clinical Trials as Topic, Humans, Imidazoles, Indazoles, Kidney Neoplasms, Neoplasm Metastasis, Neoplasms, Protein Kinase Inhibitors | null |
22,706,542 | 2015-04-09 | 2015-11-19 | 1543-0790 | Clinical advances in hematology & oncology : H&O | PARP inhibitors. | Plummer Ruth | eng | null | Journal Article | Enzyme Inhibitors, Poly(ADP-ribose) Polymerase Inhibitors | IM | 22706542 | null | Breast Neoplasms, Clinical Trials as Topic, Drug Discovery, Enzyme Inhibitors, Humans, Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Treatment Outcome | null |
22,706,547 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Embolic stroke in a patient with a patent foramen ovale and an indwelling catheter. | Khorana Alok A | eng | null | Journal Article, Review | null | IM | 22706547 | null | Antineoplastic Combined Chemotherapy Protocols, Catheters, Indwelling, Foramen Ovale, Patent, Humans, Neoplasms, Stroke | null |
22,706,541 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Umbilical cord blood transplantation in cancer therapy. | Hexner Elizabeth Olson | eng | null | Journal Article | null | IM | 22706541 | null | Bone Marrow Transplantation, Clinical Trials, Phase I as Topic, Cord Blood Stem Cell Transplantation, Hematologic Neoplasms, Humans, Neoplasm Staging, Neoplasms, Peripheral Blood Stem Cell Transplantation, Research Design | null |
22,706,546 | 2015-04-09 | 2022-03-10 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Embolic stroke secondary to an indwelling catheter in a patient with a patent foramen ovale: a case report and review of the literature. | Ahn Daniel, Brickner M Elizabeth, Dowell Jonathan | eng | null | Case Reports, Journal Article | null | IM | 22706546 | null | Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Catheterization, Central Venous, Catheters, Indwelling, Female, Foramen Ovale, Patent, Humans, Lung Neoplasms, Middle Aged, Stroke, Ultrasonography | null |
22,706,545 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Romidepsin for previously treated patients with peripheral or aggressive T-cell lymphomas. | Horwitz Steven M | eng | null | Journal Article, Review | Antineoplastic Agents, Depsipeptides, romidepsin | IM | 22706545 | null | Antineoplastic Agents, Clinical Trials, Phase II as Topic, Depsipeptides, Humans, Lymphoma, T-Cell, Treatment Outcome | null |
22,706,544 | 2015-04-09 | 2022-02-24 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Gemtuzumab: time to bring back on the market? | Foran James M | eng | null | Journal Article | Aminoglycosides, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Gemtuzumab | IM | 22706544 | null | Aminoglycosides, Antibodies, Monoclonal, Humanized, Antineoplastic Agents, Clinical Trials as Topic, Gemtuzumab, Humans, Leukemia, Myeloid, Acute, Research, Safety-Based Drug Withdrawals, Treatment Outcome | null |
22,706,543 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Regorafenib in metastatic colorectal cancer. | Grothey Axel | eng | null | Journal Article | Antineoplastic Agents, Phenylurea Compounds, Pyridines, regorafenib | IM | 22706543 | null | Antineoplastic Agents, Clinical Trials, Phase III as Topic, Colorectal Neoplasms, Humans, Neoplasm Metastasis, Palliative Care, Phenylurea Compounds, Pyridines, Research, Research Design, Treatment Outcome | null |
22,706,548 | 2015-04-09 | 2012-06-18 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Lessons learned from a complete remission of advanced metastatic pancreatic ductal adenocarcinoma. | Mathew Blessy M, Daas Adel Y, Centeno Barbara A, Hoffe Sarah, Valone Tiffany, Patel Manish, Springett Gregory M | eng | null | Case Reports, Journal Article | CA-19-9 Antigen | IM | 22706548 | null | Adult, CA-19-9 Antigen, Carcinoma, Pancreatic Ductal, Family, Female, Genes, BRCA2, Genes, ras, Humans, Induction Chemotherapy, Kinetics, Male, Mutation, Neoplasm Metastasis, Pancreatic Neoplasms, Pedigree | null |
22,706,552 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Dr. McMahon Replies. | null | eng | null | Journal Article | null | null | 22706552, 99650, 10.1176/appi.ajp.2007.07111699r | null | null | null |
22,706,549 | 2015-04-09 | 2015-11-19 | 1543-0790 | Clinical advances in hematology & oncology : H&O | Is there a case for personalized therapy of pancreatic cancer? | Dragovich Tomislav | eng | null | Journal Article, Review | BRCA2 Protein | IM | 22706549 | null | BRCA2 Protein, Humans, Pancreatic Neoplasms, Precision Medicine, Signal Transduction | null |
22,706,550 | 2013-08-01 | 2021-10-21 | 1439-6327 | European journal of applied physiology | Post-exercise cold water immersion: effect on core temperature and melatonin responses. | Robey Elisa, Dawson Brian, Halson Shona, Goodman Carmel, Gregson Warren, Eastwood Peter | eng | null | Journal Article | Melatonin | IM | 22706550, 10.1007/s00421-012-2436-3, 17620933, 19211945, 9376644, 18083634, 19308790, 2789570, 10751106, 21335348, 18295089, 12959621, 16303589, 18058595, 20560711, 17069866, 2273939, 16021839, 17364140, 8283389, 9143072, 7873953, 20161220, 12571075, 6505888, 9406031, 20403733, 18547863, 18274940 | To study the effect of post-exercise cold water immersion (CWI) on core temperature and melatonin responses, 10 male cyclists completed two evening (~1800 hours) cycling trials followed by a 15-min CWI (14 °C) or warm water immersion (WWI; 34 °C), and were then monitored for 90 min post-immersion. The exercise trial involved 15 min at 75 % peak power, followed by a 15 min time trial. Core (rectal) temperature was not different between the two conditions pre-exercise (~37.4 °C), post-exercise (~39 °C) or immediately post-immersion (~37.7 °C), but was significantly (p < 0.05) below pre-exercise levels at 60 and 90 min post-immersion in both conditions. Core temperature was significantly lower after CWI than WWI at 30 min (36.84 ± 0.24 vs. 37.42 ± 0.40 °C, p < 0.05) and 90 min (36.64 ± 0.24 vs. 36.95 ± 0.43 °C, p < 0.05) post-immersion. Salivary melatonin levels significantly increased (p < 0.05) from post-exercise (~5 pM) to 90 min post-immersion (~8.3 pM), but were not different between conditions. At 30 and 90 min post-immersion heart rate was significantly lower (~5-10 bpm, p < 0.01) after CWI than WWI. These results show that undertaking either CWI or WWI post-exercise in the evening lowers core temperature below baseline for at least 90 min; however, the magnitude of decrease is significantly greater following CWI. The usual evening increase in melatonin is unaffected by exercise or post-exercise water immersion undertaken between ~1800 and ~2000 hours. | Adaptation, Physiological, Adult, Bicycling, Body Temperature, Cold Temperature, Humans, Immersion, Male, Melatonin, Physical Exertion, Saliva | null |
22,706,551 | 2012-12-07 | 2021-10-21 | 1432-1106 | Experimental brain research | Audiovisual crossmodal correspondences and sound symbolism: a study using the implicit association test. | Parise Cesare V, Spence Charles | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22706551, 10.1007/s00221-012-3140-6, 17999607, 2299041, 22808586, 20465176, 21787871, 22396404, 21688942, 13720232, 19679162, 18217847, 16648449, 16843040, 15766764, 12842029, 3837874, 11164734, 20470860, 16683501, 21264748, 19828141, 21901453, 1109455, 6080197, 17570599, 23145286, 18979385, 20143899, 13429016, 17355042, 2587966, 22648604, 22177899, 1161435, 5217429, 17331789, 6844102, 10935623, 8083631, 21219918, 18638522, 9654756, 22143791, 17925208, 15833304, 20424017, 16762303, 808744, 2527964, 5542226, 17853248, 12063137, 19471644, 6844060, 2958587 | A growing body of empirical research on the topic of multisensory perception now shows that even non-synaesthetic individuals experience crossmodal correspondences, that is, apparently arbitrary compatibility effects between stimuli in different sensory modalities. In the present study, we replicated a number of classic results from the literature on crossmodal correspondences and highlight the existence of two new crossmodal correspondences using a modified version of the implicit association test (IAT). Given that only a single stimulus was presented on each trial, these results rule out selective attention and multisensory integration as possible mechanisms underlying the reported compatibility effects on speeded performance. The crossmodal correspondences examined in the present study all gave rise to very similar effect sizes, and the compatibility effect had a very rapid onset, thus speaking to the automatic detection of crossmodal correspondences. These results are further discussed in terms of the advantages of the IAT over traditional techniques for assessing the strength and symmetry of various crossmodal correspondences. | Acoustic Stimulation, Adolescent, Adult, Association, Attention, Auditory Perception, Female, Humans, Male, Photic Stimulation, Reaction Time, Symbolism, Visual Perception | null |
22,706,553 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Drs. Shim and Kelly Reply. | null | eng | null | Journal Article | null | null | 22706553, 99653, 10.1176/appi.ajp.2007.07111738r | null | null | null |
22,706,556 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | null | null | eng | null | Journal Article | null | null | 22706556, 99670, 10.1176/appi.ajp.2007.165.3.401 | null | null | null |
22,706,554 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Dr. Mamo Replies. | null | eng | null | Journal Article | null | null | 22706554, 99657, 10.1176/appi.ajp.2007.07091513r | null | null | null |
22,706,557 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | The Center Cannot Hold: My Journey Through Madness. | null | eng | null | Journal Article | null | null | 22706557, 99673, 10.1176/appi.ajp.2007.07111814 | null | null | null |
22,706,555 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Dr. Suri Replies. | null | eng | null | Journal Article | null | null | 22706555, 99663, 10.1176/appi.ajp.2007.07081361r | null | null | null |
22,706,560 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Handbook of PTSD: Science and Practice. | null | eng | null | Journal Article | null | null | 22706560, 99680, 10.1176/appi.ajp.2007.07121921 | null | null | null |
22,706,559 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Drug-Drug Interaction Primer: A Compendium of Case Vignettes for the Practicing Clinician. | null | eng | null | Journal Article | null | null | 22706559, 99677, 10.1176/appi.ajp.2007.07121849 | null | null | null |
22,706,558 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Me, Myself, and Them: A Firsthand Account of One Young Person's Experience With Schizophrenia. | null | eng | null | Journal Article | null | null | 22706558, 99675, 10.1176/appi.ajp.2007.07121842 | null | null | null |
22,706,561 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | null | null | eng | null | Journal Article | null | null | 22706561, 99683, 10.1176/appi.ajp.2008.165.3.406 | null | null | null |
22,706,565 | 2012-10-26 | 2012-06-26 | 1364-548X | Chemical communications (Cambridge, England) | High performance silicon nanoparticle anode in fluoroethylene carbonate-based electrolyte for Li-ion batteries. | Lin Yong-Mao, Klavetter Kyle C, Abel Paul R, Davy Nicholas C, Snider Jonathan L, Heller Adam, Mullins C Buddie | eng | null | Journal Article | null | null | 22706565, 10.1039/c2cc31712e | Electrodes composed of silicon nanoparticles (SiNP) were prepared by slurry casting and then electrochemically tested in a fluoroethylene carbonate (FEC)-based electrolyte. The capacity retention after cycling was significantly improved compared to electrodes cycled in a traditional ethylene carbonate (EC)-based electrolyte. | null | null |
22,706,564 | 2013-01-14 | 2021-10-21 | 1433-0458 | HNO | [Exostoses of the external auditory canal in professional diving. A case for the German Social Accident Insurance Institution]. | Heinmüller M, Nowak D, Stelter K | ger | null | English Abstract, Journal Article, Review | null | IM | 22706564, 10.1007/s00106-011-2475-9, 14880790, 21822855, 18603582, 9566088, 3812656, 21493286, 831701, 10595337, 7580769, 10663060, 13904891, 17851642, 7162188, 2725159, 1403319, 18346299, 1571064, 20066729 | Exostoses of the external auditory canal are often diagnosed incidentally but may also cause complications, e.g., conductive hearing loss and/or recurrent inflammations of the external ear canal due to stenosis. This paper presents current scientific data on the pathogenesis of ear canal exostoses, which obviously focus on the cold water hypothesis. We present a case of an expert opinion on occupational illness and discuss whether the legal preconditions for recognition "like an occupational disease" according to article 9(2) Social Code Book VII are met. A systematic reporting of suspected cases is recommended in order to obtain reliable data on the epidemiology and the clinical course of external auditory exostoses among individuals occupationally exposed to cold water and to enter an expert discussion on the reasonability of an inclusion in the list of occupational diseases. | Cold Temperature, Diving, Ear Canal, Exostoses, Germany, Humans, Occupational Diseases, Otitis Externa | null |
22,706,567 | 2013-05-01 | 2021-10-21 | 1435-604X | Lasers in medical science | Low-level laser therapy for oral mucous membrane pemphigoid. | Cafaro Adriana, Broccoletti Roberto, Arduino Paolo Giacomo | eng | null | Clinical Trial, Journal Article | null | IM | 22706567, 10.1007/s10103-012-1137-9, 17141573, 20450370, 17628849, 15841638, 17293815, 17804127, 20950190, 22174176, 16942428, 14962242, 10805940, 20738169, 11902988, 19878031, 9612167, 20949231, 18084808, 5098661, 10979236 | null | Aged, Aged, 80 and over, Female, Follow-Up Studies, Gingival Diseases, Humans, Low-Level Light Therapy, Male, Pemphigoid, Benign Mucous Membrane, Treatment Outcome | null |
22,706,568 | 2012-10-29 | 2012-07-05 | 1473-0189 | Lab on a chip | High throughput method for prototyping three-dimensional, paper-based microfluidic devices. | Lewis Gregory G, DiTucci Matthew J, Baker Matthew S, Phillips Scott T | eng | null | Journal Article | null | null | 22706568, 10.1039/c2lc40331e | This paper describes an efficient and high throughput method for fabricating three-dimensional (3D) paper-based microfluidic devices. The method avoids tedious alignment and assembly steps and eliminates a major bottleneck that has hindered the development of these types of devices. A single researcher now can prepare hundreds of devices within 1 h. | null | null |
22,706,570 | 2013-01-09 | 2016-11-25 | 1463-9084 | Physical chemistry chemical physics : PCCP | Paths of long-range communication in the E2 enzymes of family 3: a molecular dynamics investigation. | Papaleo Elena, Lindorff-Larsen Kresten, De Gioia Luca | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Ubiquitin-Conjugating Enzymes | IM | 22706570, 10.1039/c2cp41224a | Molecular dynamics (MD) simulations have the ability to help reveal the relationship between protein structure, dynamics and function. Here, we describe MD simulations of the representative members of family 3 of E2 enzymes that we performed and analyzed with the aim of providing a quantitative description of the functional dynamics in this biologically important set of proteins. In particular, we combined a description of the protein as a network of interacting residues with the dynamical cross-correlation method to characterize the correlated motions observed in the simulations. This approach enabled us to detect communication between distal residues in these enzymes, and thus to reliably define all the likely intramolecular pathways of communication. We observed functionally relevant differences between the closed and open conformations of the enzyme, and identified the critical residues involved in the long-range communication paths. Our results highlight how molecular simulations can be used to aid in providing atomic-level details to communication paths within proteins. | Models, Molecular, Molecular Dynamics Simulation, Ubiquitin-Conjugating Enzymes | null |
22,706,563 | 2013-04-24 | 2021-10-21 | 1433-0458 | HNO | [Bevacizumab in therapy-refractory epistaxis: case report of low-dose antibody therapy for hereditary hemorrhagic telangiectasia]. | Rohrmeier C, Kühnel T S | ger | null | Case Reports, English Abstract, Journal Article | Angiogenesis Inhibitors, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Bevacizumab | IM | 22706563, 10.1007/s00106-011-2458-x, 12080621, 21344445, 18256841, 15794077, 16270607, 10946360, 16807748, 21344447, 12975554 | We report on the submucosal injection of bevacizumab (Avastin) at a dose of 0.3 to 3.75 mg per side in a patient with hereditary hemorrhagic telangiectasia. Application of such low doses has not been described in the literature yet. Our case report shows the positive effect of low-dose bevacizumab on therapy-refractory epistaxis. No complications were caused by the bevacizumab treatment. | Angiogenesis Inhibitors, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Bevacizumab, Epistaxis, Female, Humans, Middle Aged, Telangiectasia, Hereditary Hemorrhagic, Treatment Outcome | null |
22,706,569 | 2012-11-09 | 2013-11-21 | 2040-3372 | Nanoscale | Indium tin oxide-coated glass modified with reduced graphene oxide sheets and gold nanoparticles as disposable working electrodes for dopamine sensing in meat samples. | Yang Jiang, Strickler J Rudi, Gunasekaran Sundaram | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Tin Compounds, Uric Acid, indium tin oxide, Gold, Graphite, Ascorbic Acid, Dopamine | IM | 22706569, 10.1039/c2nr30618b | Sensitive, rapid, and accurate detection of dopamine (DA) at low cost is needed for clinical diagnostic and therapeutic purposes as well as to prevent illegal use of DA in animal feed. We employed a simple approach to synthesize reduced graphene oxide sheets (rGOS) and gold nanoparticles (AuNPs) at room temperature on indium tin oxide-coated glass (ITO) slides as disposable working electrodes for sensing DA. Graphene oxide (GO) was directly reduced on ITO to remove oxygenated species via a rapid and green process without using chemical reducing reagents. AuNPs were electrochemically deposited in situ on rGOS-ITO with fairly uniform density and size. The sensitivity of the AuNPs-rGOS-ITO sensor for DA detection is 62.7 μA mM(-1) cm(-2) with good selectivity against common electrochemically interfering species such as ascorbic acid (AA) and uric acid (UA), and the detection limit measured by differential pulse voltammetry (DPV), at a signal-noise ratio of 3, was 6.0 × 10(-8) M. The electrochemical catalysis of DA was proven to be a surface process with an electron transfer coefficient (α) of 0.478 and a rate constant (k(s)) of 1.456 s(-1). It correlates well with the conventional UV-vis spectrophotometric approach (R = 0.9973) but with more than thrice the dynamic range (up to 4.5 mM). The sensor also exhibited good stability and capability to detect DA in beef samples, and thus is a promising candidate for simple and inexpensive sub-nanomolar detection of DA, especially in the presence of UV-absorbing compounds. | Animals, Ascorbic Acid, Biosensing Techniques, Catalysis, Cattle, Dopamine, Electrochemical Techniques, Electrodes, Glass, Gold, Graphite, Meat, Metal Nanoparticles, Oxidation-Reduction, Tin Compounds, Uric Acid | null |
22,706,571 | 2013-01-25 | 2018-12-01 | 1572-8773 | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine | Effect of intravenous vitamin C on cytokine activation and oxidative stress in end-stage renal disease patients receiving intravenous iron sucrose. | Conner Todd A, McQuade Charles, Olp Jonathan, Pai Amy Barton | eng | null | Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | Cytokines, F2-Isoprostanes, Ferric Compounds, Reactive Oxygen Species, Recombinant Proteins, Erythropoietin, Epoetin Alfa, Ferric Oxide, Saccharated, Ascorbic Acid, Glucaric Acid | IM | 22706571, 10.1007/s10534-012-9562-6 | Reticuloendothelial blockade in hemodialysis patients prevents optimal intravenous (IV) iron utilization. Vitamin C has emerged as a potential therapy to improve anemia treatment by enhancing iron mobilization. However, Vitamin C can act as a pro-oxidant in the presence of iron. This was a prospective, open-label, crossover study. Thirteen patients with end-stage renal disease on hemodialysis and four healthy controls were assigned to receive 100 mg of IV iron sucrose (IS) or 100 mg of IV IS co-administered with 300 mg of IV Vitamin C (IS + C) in random sequence. Serum samples for IL-1, IL-6, TNF-α and IL-10 and non-transferrin bound iron were obtained at baseline, 45 min and 105 min post study medication administration. Peripheral blood mononuclear cells were isolated at the same time points and stained with fluorescent probes to identify intracellular reactive oxygen species and mitochondrial membrane potential (Δψm) by flow cytometry. Lipid peroxidation was assessed by plasma F2-isoprosatane concentration. Both IS and IS + C were associated with increased plasma F2-isoprostanes concentrations post-infusion. Maximal plasma F2-isoprostane concentrations after IS + C were significantly elevated from baseline (234 ± 0.04 vs. 0.198 ± 0.028 ng/mL, p = 0.02). After IS + C, IL-1, IL-6, IL-10, and TNF-alpha were significantly elevated compared to baseline. After IS alone only IL-6 was noted to be elevated. Intracellular production of H(2)O(2) and loss of mitochondrial membrane potential (Δψm) was observed after IS while IS + C was associated with increased O (2) (·-) production. Both IS and IS + C induced serum cytokine activation accompanied by lipid peroxidation, however, IS + C induced higher plasma concentrations of F2-isoprostanes, IL-1, IL-10, and TNF-α post-infusion. Long-term safety studies of IV iron co-administered with Vitamin C are warranted. | Adult, Ascorbic Acid, Cross-Over Studies, Cytokines, Epoetin Alfa, Erythropoietin, F2-Isoprostanes, Female, Ferric Compounds, Ferric Oxide, Saccharated, Glucaric Acid, Humans, Infusions, Intravenous, Kidney Failure, Chronic, Lipid Peroxidation, Male, Membrane Potential, Mitochondrial, Middle Aged, Oxidative Stress, Prospective Studies, Reactive Oxygen Species, Recombinant Proteins, Systems Biology | null |
22,706,566 | 2012-10-26 | 2013-11-21 | 1361-6528 | Nanotechnology | Effect of electron-vibration interactions on the thermoelectric efficiency of molecular junctions. | Hsu Bailey C, Chiang Chi-Wei, Chen Yu-Chang | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Benzene | IM | 22706566, 10.1088/0957-4484/23/27/275401 | From first-principles approaches, we investigate the thermoelectric efficiency of a molecular junction where a benzene molecule is connected directly to the platinum electrodes. We calculate the thermoelectric figure of merit ZT in the presence of electron-vibration interactions with and without local heating under two scenarios: linear response and finite bias regimes. In the linear response regime, ZT saturates around the electrode temperature T(e) = 25 K in the elastic case, while in the inelastic case we observe a non-saturated and a much larger ZT beyond T(e) = 25 K attributed to the tail of the Fermi-Dirac distribution. In the finite bias regime, the inelastic effects reveal the signatures of the molecular vibrations in the low-temperature regime. The normal modes exhibiting structures in the inelastic profile are characterized by large components of atomic vibrations along the current density direction on top of each individual atom. In all cases, the inclusion of local heating leads to a higher wire temperature T(w) and thus magnifies further the influence of the electron-vibration interactions due to the increased number of local phonons. | Benzene, Computer Simulation, Electron Transport, Electrons, Hot Temperature, Microelectrodes, Models, Chemical, Nanoparticles, Vibration | null |
22,706,577 | 2013-12-03 | 2016-10-18 | 1533-4287 | Journal of strength and conditioning research | The perception of psychology and the frequency of psychological strategies used by strength and conditioning practitioners. | Radcliffe Jon N, Comfort Paul, Fawcett Tom | eng | null | Journal Article | null | IM | 22706577, 10.1519/JSC.0b013e3182606ddc | The study aimed to first examine the frequency of the psychological skills and strategies of strength and conditioning practitioners and second distinguish between demographic differences in relation to psychological skills and strategy use. The Strength and Conditioning Sport Psychology Questionnaire was developed to measure the frequency of use of 11 subscales. These consisted of goal setting, imagery, self-talk, mental toughness, attention control, relaxation, stress management, adherence, activation, self-confidence, and ego management. Each subscale demonstrated acceptable internal validity ale (mean interitem correlations ranged as 0.227-0.427). The instrument allowed up to 5 open-ended responses concerning skills considered most important to strength and conditioning practice and up to 5 psychological attributes considered detrimental within strength and conditioning. One hundred and two participants met the inclusion criteria (90 men and 12 women; age 34.7 ± 9.7 years; experience 7.4 ± 5.2 years; part time 36.5%; full time 63.5%). The respondents were registered with the following organizations: United Kingdom Strength and Conditioning Association: 41, National Strength and Conditioning Association: 48 and Australian Strength and Conditioning Association (ASCA): 48. Goal setting was found to be the most frequently used skill with mental imagery the least used with significant differences identified in the frequency of skill use. The strategies deemed to be most important were motivation and confidence with the most debilitating factors identified as a lack of motivation and a lack of confidence. When comparing demographics, overall skill use varied between practitioners with different experience with more experienced practitioners having greater skill use, both overall and particular individual skills. Participants accredited by the ASCA had a greater psychological skill use than those accredited by other bodies. | Accreditation, Adult, Attention, Ego, Exercise, Female, Goals, Humans, Male, Motivation, Perception, Professional Competence, Relaxation, Resistance Training, Self Efficacy, Sports, Statistics, Nonparametric, Stress, Psychological, Surveys and Questionnaires | null |
22,706,576 | 2013-12-03 | 2016-10-18 | 1533-4287 | Journal of strength and conditioning research | Correlation of throwing velocity to the results of lower-body field tests in male college baseball players. | Lehman Graeme, Drinkwater Eric J, Behm David G | eng | null | Journal Article | null | IM | 22706576, 10.1519/JSC.0b013e3182606c79 | Baseball-specific athleticism, potential, and performance have been difficult to predict. Increased muscle strength and power can increase throwing velocity but the majority of research has focused on the upper body. The present study sought to determine if bilateral or unilateral lower-body field testing correlates with throwing velocity. Baseball throwing velocity scores were correlated to the following tests: medicine ball (MB) scoop toss and squat throw, bilateral and unilateral vertical jumps, single and triple broad jumps, hop and stop in both directions, lateral to medial jumps, 10- and 60-yd sprints, and both left and right single-leg 10-yd hop for speed in 42 college baseball players. A multiple regression analysis (forward method), assessing the relationship between shuffle and stretch throwing velocities and lower-body field test results determined that right-handed throwing velocity from the stretch position was most strongly predicted by lateral to medial jump right (LMJR) and body weight (BW; R = 0.322), whereas lateral to medial jump left (LMJL; R = 0.688) predicted left stretch throw. Right-handed shuffle throw was most strongly predicted by LMJR and MB scoop (R = 0.338), whereas LMJL, BW, and LMJR all contributed to left-handed shuffle throw (R = 0.982). Overall, this study found that lateral to medial jumps were consistently correlated with high throwing velocity in each of the throwing techniques, in both left-handed and right-handed throwers. This is the first study to correlate throwing velocity with a unilateral jump in the frontal plane, mimicking the action of the throwing stride. | Adolescent, Adult, Athletic Performance, Baseball, Body Weight, Humans, Lower Extremity, Male, Movement, Muscle Strength, Muscle, Skeletal, Young Adult | null |
22,706,575 | 2013-11-18 | 2016-10-18 | 1533-4287 | Journal of strength and conditioning research | A simple method to analyze overall individual physical fitness in firefighters. | Calavalle Anna R, Sisti Davide, Mennelli Giacomina, Andolina Giuseppe, Del Sal Marta, Rocchi Marco B L, Benelli Piero, Stocchi Vilberto | eng | null | Journal Article | null | IM | 22706575, 10.1519/JSC.0b013e3182600554 | The aim of this study was to identify the main components that determine firefighters' level of physical fitness using a stair-climbing test. The age, weight, height, body fat, and VO(2max) of the firefighters were recorded before the trial, and percentage of heart rate reserve (%HRR) was recorded during the stair climbing. Nonlinear modeling of HRR time series and Principal Component Analysis (PCA) was applied to the data to isolate a small number of variables that quantify overall individual physical fitness. The HRR was represented as a function of time using the sum of linear and trigonometric functions. Four main factors that influence performance, obtained from PCA analysis, emerged (78.2% of total explained variance): the capacity to carry the extra load (22.8% of total variance); the effect of body fat (19.6% of total variance); the influence of age in the task (19.3% of total variance); and the overall fitness level (16.4% of total variance). This approach allowed us to make a rapid assessment of each subject's fitness level. Such an assessment could be used in planning individualized functional training programs to improve each firefighter's job performance and reduce injuries and hence save time, energy, and financial resources. | Adult, Age Factors, Body Fat Distribution, Exercise Test, Firefighters, Heart Rate, Humans, Male, Middle Aged, Oxygen Consumption, Physical Fitness, Principal Component Analysis | null |
22,706,578 | 2013-01-09 | 2016-10-18 | 1533-4287 | Journal of strength and conditioning research | The effects of undergarment composition worn beneath hockey protective equipment on high-intensity intermittent exercise. | Noonan Benjamin, Stachenfeld Nina | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22706578, 10.1519/JSC.0b013e3182606e1e | The purpose of this study was to examine the impact of undergarment composition worn beneath ice hockey protective equipment on thermal homeostasis and power output, during a cycle ergometer exercise protocol designed to simulate the energy expenditure of a hockey game. We hypothesized that the layers of protective equipment would negate the potential thermoregulatory benefits from synthetic "wicking" undergarments but that subjects may feel more comfortable because of the inherent low moisture retention of these fabrics. Eight men (age, 25.4 ± 1.3 year) performed a repeated sprint test before and after a simulated game under typical hockey conditions (12°C; 82% relative humidity). This test was completed twice while wearing full protective equipment and either synthetic (SYN) or cotton (COT) full-length undergarments. During the simulated game, skin temperatures (34.22 ± 0.20°C vs. 34.46 ± 0.16°C) and core temperatures (37.50 ± 0.13°C vs. 37.59 ± 0.14°C) were similar between SYN and COT, respectively. There were also no significant differences found in sweat loss as a percent of body mass, heart rate, plasma lactate, sprint power, or ratings of perceived exertion between SYN and COT, respectively. The SYN retained less water than COT (140 ± 30 vs. 310 ± 30 g; p < 0.05); however, clothing and protective equipment weight gains as a whole were unaffected by the fabric worn (470 ± 110 vs. 590 ± 80 g) for SYN and COT, respectively. There were minimal differences in thermal sensation and undergarment wetness ratings during the simulated game. Thermoregulation and performance was driven more by properties of the layered protective equipment with minimal effects from undergarment composition. | Adult, Body Temperature, Clothing, Energy Metabolism, Heart Rate, Hockey, Humans, Male, Oxygen Consumption, Physical Exertion, Protective Clothing, Sweating, Textiles | null |
22,706,574 | 2013-12-03 | 2016-10-18 | 1533-4287 | Journal of strength and conditioning research | Responsiveness of the one-leg hop test and the square hop test to fatiguing intermittent aerobic work and subsequent recovery. | Ros Anette G M, Holm Susanne E, Fridén Cecilia, Heijne Annette I-L M | eng | null | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't | Lactic Acid | IM | 22706574, 10.1519/JSC.0b013e31825feb5b | The purpose of the present study was to evaluate the responsiveness of the 1-leg hop test and the square hop (SH) test to fatiguing intermittent aerobic work and during recovery. A further aim was to study sex differences in trends. Members of 4 sub-elite-level soccer teams were invited to participate. Ten men (mean ± SD) aged 20.7 ± 3.4 years and 10 women aged 21.8 ± 4.8 years accepted to participate in the test. The Yo-Yo intermittent Endurance test Level 2, was used as a standardized sport-specific fatiguing protocol. The 1-leg hop test and the SH test were performed before, immediately after, 15, and 30 minutes after the fatiguing exercise. To quantify the level and progression of fatigue and recovery, blood lactate and heart rate were measured, and general fatigue was estimated on Borg's rating of perceived exertion scale. No significant difference in performance in either of the hop tests was found immediately after intermittent aerobic fatiguing work. Performance in the 1-leg hop test significantly decreased (p = 0.002), whereas that in the SH test increased (p = 0.001) between baseline and 15-30 minutes after fatiguing work. No significant difference in trends between sexes was found. The performance in the 1-leg hop test significantly decreased during 30 minutes of recovery compared with that in the nonfatigued conditions and might therefore be used on the field as a complement to other physical parameters to detect remaining fatigue. Note that the 1-leg hop test did not immediately respond to intermittent aerobic work. It is not recommended to use the SH test for measuring fatigue and subsequent recovery because the performance constantly increased despite the present objective and subjective fatigue. | Adolescent, Adult, Exercise, Exercise Test, Fatigue, Female, Heart Rate, Humans, Lactic Acid, Male, Physical Endurance, Physical Exertion, Sex Factors, Task Performance and Analysis, Young Adult | null |
22,706,572 | 2013-06-25 | 2021-10-21 | 1435-5922 | Journal of gastroenterology | Intermittent clamping is superior to ischemic preconditioning and its effect is more marked with shorter clamping cycles in the rat liver. | Seyama Yasuji, Imamura Hiroshi, Inagaki Yoshinori, Matsuyama Yutaka, Tang Wei, Makuuchi Masatoshi, Kokudo Norihiro | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't | Alanine Transaminase, Glutathione | IM | 22706572, 10.1007/s00535-012-0613-0, 1576495, 11447039, 12488232, 14586882, 12163383, 8954116, 10611167, 17122617, 7834822, 9531309, 14631221, 8298928, 9731571, 18581460, 11965582, 15162475, 8178341, 14609867, 3810429, 10077050, 14517806, 9731570, 12540778, 17862242, 9625316, 1412719, 17071204, 9397992, 7611865, 9096600, 17665306, 7627525, 10077049, 3586626, 11172341, 12084933, 9973313, 12796583, 9409569, 11882762, 8053742 | Intermittent clamping (IC) and ischemic preconditioning (PC) reportedly protect the liver against the ischemia/reperfusion (I/R) injury induced by inflow occlusion during hepatectomy. While IC cycles consisting of 15 min of clamping with 5 min of reperfusion are used empirically, the optimal IC cycle has not been established. We compared the effects of various cycles of IC and PC in the rat liver. | Alanine Transaminase, Animals, Apoptosis, Bile, Blood Loss, Surgical, Constriction, Glutathione, Hepatectomy, Hepatocytes, Ischemic Preconditioning, Liver, Liver Diseases, Male, Necrosis, Rats, Rats, Wistar, Reperfusion Injury, Time Factors | null |
22,706,573 | 2013-06-25 | 2021-10-21 | 1435-5922 | Journal of gastroenterology | Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors. | Chen Ming-Huang, Yeh Yi-Chen, Shyr Yi-Ming, Jan Yi-Hua, Chao Yee, Li Chung-Pin, Wang Shin-E, Tzeng Cheng-Hwai, Chang Peter Mu-Hsin, Liu Chun-Yu, Chen Ming-Han, Hsiao Michael, Huang Chi-Ying F | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Biomarkers, Tumor, GREM1 protein, human, Intercellular Signaling Peptides and Proteins | IM | 22706573, 10.1007/s00535-012-0614-z, 9059336, 20660291, 20940408, 22182508, 20966805, 20042676, 15933475, 20068079, 16234815, 12135612, 14570746, 14517793, 1701519, 18565894, 15558070, 17077323, 7491141, 9234736, 17200354, 11531144 | Gremlin 1 (GREM1) is a bone morphogenetic protein antagonist and a novel proangiogenic factor. Our aim was to evaluate the prognostic value of GREM1 expression and GREM1-related factors in tumor-associated angiogenesis in pancreatic neuroendocrine tumors (NETs). | Adult, Aged, Biomarkers, Tumor, Disease-Free Survival, Female, Humans, Immunohistochemistry, Intercellular Signaling Peptides and Proteins, Kaplan-Meier Estimate, Male, Microvessels, Middle Aged, Neovascularization, Pathologic, Neuroendocrine Tumors, Pancreatic Neoplasms, Young Adult | null |
22,706,579 | 2012-10-24 | 2012-07-03 | 1477-9234 | Dalton transactions (Cambridge, England : 2003) | Luminescence properties of Mn(2+)-doped Li2ZnGeO4 as an efficient green phosphor for field-emission displays with high color purity. | Shang Mengmeng, Li Guogang, Yang Dongmei, Kang Xiaojiao, Peng Chong, Lin Jun | eng | null | Journal Article | null | null | 22706579, 10.1039/c2dt30670k | Green emitting Li(2)ZnGeO(4):Mn(2+) phosphors were synthesized through a high temperature solid-state reaction process. X-Ray diffraction, field emission scanning electron microscopy, photoluminescence (PL) and cathodoluminescence (CL) spectra were utilized to characterize the synthesized samples. Under UV and electron-beam excitation, the pure Li(2)ZnGeO(4) sample shows a blue emission due to defects, while the Li(2)ZnGeO(4):Mn(2+) sample exhibits a green emission corresponding to the characteristic transition of Mn(2+) ((4)T(1)→(6)A(1)). In particular, the CL intensity (brightness) of Li(2)ZnGeO(4):Mn(2+) is higher than that of commercial green phosphor ZnO:Zn. In addition, the CL properties of Li(2)ZnGeO(4):Mn(2+) phosphor, the dependence of CL intensity on accelerating voltage and filament current, the decay behavior of CL intensity under electron bombardment, and the stability of CIE chromaticity coordinates, have been investigated in detail. The results indicate that the as-prepared Li(2)ZnGeO(4):Mn(2+) phosphor has a good CL intensity and CIE coordinate stability with green emission under low-voltage electron beam excitation. Therefore, Li(2)ZnGeO(4):Mn(2+) is a promising green phosphor for application in full-color field-emission displays. | null | null |
22,706,581 | 2012-08-29 | 2021-10-21 | 1940-087X | Journal of visualized experiments : JoVE | A fluorescent screening assay for identifying modulators of GIRK channels. | Vazquez Maribel, Dunn Charity A, Walsh Kenneth B | eng | R21 NS071530 (NINDS NIH HHS, United States); R25 GM066526 (NIGMS NIH HHS, United States); R25 GM076277 (NIGMS NIH HHS, United States); NS-071530 (NINDS NIH HHS, United States) | Journal Article, Research Support, U.S. Gov't, P.H.S., Video-Audio Media | Fluorescent Dyes, G Protein-Coupled Inwardly-Rectifying Potassium Channels | IM | 22706581, 3850, 10.3791/3850, PMC3466633, 10838414, 10415083, 14567780, 20389305, 17168757, 18171729, 20658944, 8428201, 11926362, 9748337, 11689132, 20086079 | G protein-gated inward rectifier K+ (GIRK) channels function as cellular mediators of a wide range of hormones and neurotransmitters and are expressed in the brain, heart, skeletal muscle and endocrine tissue(1,2). GIRK channels become activated following the binding of ligands (neurotransmitters, hormones, drugs, etc.) to their plasma membrane-bound, G protein-coupled receptors (GPCRs). This binding causes the stimulation of G proteins (Gi and Go) which subsequently bind to and activate the GIRK channel. Once opened the GIRK channel allows the movement of K+ out of the cell causing the resting membrane potential to become more negative. As a consequence, GIRK channel activation in neurons decreases spontaneous action potential formation and inhibits the release of excitatory neurotransmitters. In the heart, activation of the GIRK channel inhibits pacemaker activity thereby slowing the heart rate. GIRK channels represent novel targets for the development of new therapeutic agents for the treatment neuropathic pain, drug addiction, cardiac arrhythmias and other disorders(3). However, the pharmacology of these channels remains largely unexplored. Although a number of drugs including anti-arrhythmic agents, antipsychotic drugs and antidepressants block the GIRK channel, this inhibition is not selective and occurs at relatively high drug concentrations(3). Here, we describe a real-time screening assay for identifying new modulators of GIRK channels. In this assay, neuronal AtT20 cells, expressing GIRK channels, are loaded with membrane potential-sensitive fluorescent dyes such as bis-(1,3-dibutylbarbituric acid) trimethine oxonol [DiBAC4(3)] or HLB 021-152 (Figure 1). The dye molecules become strongly fluorescent following uptake into the cells (Figure 1). Treatment of the cells with GPCR ligands stimulates the GIRK channels to open. The resulting K+ efflux out of the cell causes the membrane potential to become more negative and the fluorescent signal to decrease (Figure 1). Thus, drugs that modulate K+ efflux through the GIRK channel can be assayed using a fluorescent plate reader. Unlike other ion channel screening assays, such atomic absorption spectrometry(4) or radiotracer analysis(5), the GIRK channel fluorescent assay provides a fast, real-time and inexpensive screening procedure. | Animals, Cell Line, Tumor, Drug Evaluation, Preclinical, Fluorescent Dyes, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Mice, Spectrometry, Fluorescence | null |
22,706,580 | 2013-08-01 | 2021-10-21 | 1439-6327 | European journal of applied physiology | Adaptations in muscle metabolic regulation require only a small dose of aerobic-based exercise. | Green Howard J, Burnett Margaret, Jacobs Ira, Ranney Don, Smith Ian, Tupling Susan | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Phosphates | IM | 22706580, 10.1007/s00421-012-2434-5, 16825308, 8847253, 19596898, 2917917, 7389042, 12015357, 7107798, 7713804, 1566823, 7671190, 19245652, 8806937, 10644545, 19710384, 16690705, 20100740, 20308248, 2187852, 18955383, 19243572, 1858860, 1864784, 8730405, 17991697, 7653539, 4852173, 12150572, 13343, 8638693, 19443744, 9053394, 9688884, 12494457, 18292295, 7201906, 18362686, 4272644, 16051629, 19474386, 17722947, 1474039, 12901719, 8779956, 8567554, 6373687, 16731801, 21081705, 10409126, 18650322, 7928887, 12181291, 8779948, 2078830, 18417645, 1559923, 20028849, 12556346, 16709650 | This study investigated the hypothesis that the duration of aerobic-based cycle exercise would affect the adaptations in substrate and metabolic regulation that occur in vastus lateralis in response to a short-term (10 day) training program. Healthy active but untrained males (n = 7) with a peak aerobic power ([Formula: see text]) of 44.4 ± 1.4 ml kg(-1) min(-1) participated in two different training programs with order randomly assigned (separated by ≥2 weeks). The training programs included exercising at a single intensity designated as light (L) corresponding to 60 % [Formula: see text], for either 30 or 60 min. In response to a standardized task (60 % [Formula: see text]), administered prior to and following each training program, L attenuated the decrease (P < 0.05) in phosphocreatine and the increase (P < 0.05) in free adenosine diphosphate and free adenosine monophosphate but not lactate. These effects were not altered by daily training duration. In the case of muscle glycogen, training for 60 versus 30 min exaggerated the increase (P < 0.05) that occurred, an effect that extended to both rest and exercise concentrations. No changes were observed in [Formula: see text] measured during progressive exercise to fatigue or in [Formula: see text] and RER during submaximal exercise with either training duration. These findings indicate that reductions in metabolic strain, as indicated by a more protected phosphorylation potential, and higher glycogen reserves, can be induced with a training stimulus of light intensity applied for as little as 30 min over 10 days. Our results also indicate that doubling the duration of daily exercise at L although inducing increased muscle glycogen reserves did not result in a greater metabolic adaptation. | Adaptation, Physiological, Exercise, Humans, Male, Muscle, Skeletal, Oxygen Consumption, Phosphates, Physical Exertion, Physical Fitness, Young Adult | null |
22,706,582 | 2013-07-19 | 2022-04-08 | 1573-3432 | Journal of autism and developmental disorders | Use of computer-assisted technologies (CAT) to enhance social, communicative, and language development in children with autism spectrum disorders. | Ploog Bertram O, Scharf Alexa, Nelson DeShawn, Brooks Patricia J | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | null | IM | 22706582, 10.1007/s10803-012-1571-3, 6681741, 18626761, 11706865, 16639533, 16897375, 20484323, 16492133, 15541632, 7430288, 10542971, 11315539, 20192553, 11261466, 16533076, 16283086, 11039862, 15449520, 19721729, 11055457, 20072702, 14714934, 18633780, 16600069, 20484002, 15162930, 8152382, 19763807, 20484000, 20603897, 20488823, 16940315, 12639328, 4800391, 12218436, 7814313, 17072749, 16477515, 11569584, 11708589, 8682895, 9652099, 11918110, 20238154, 17072754, 2934210, 8567593 | Major advances in multimedia computer technology over the past decades have made sophisticated computer games readily available to the public. This, combined with the observation that most children, including those with autism spectrum disorders (ASD), show an affinity to computers, has led researchers to recognize the potential of computer technology as an effective and efficient tool in research and treatment. This paper reviews the use of computer-assisted technology (CAT), excluding strictly internet-based approaches, to enhance social, communicative, and language development in individuals with ASD by dividing the vast literature into four main areas: language, emotion recognition, theory of mind, and social skills. Although many studies illustrate the tremendous promise of CAT to enhance skills of individuals with ASD, most lack rigorous, scientific assessment of efficacy relative to non-CAT approaches. | Child, Child Development Disorders, Pervasive, Communication, Humans, Language, Language Development, Language Development Disorders, Social Behavior, Theory of Mind, Therapy, Computer-Assisted | null |
22,706,583 | 2013-07-19 | 2021-10-21 | 1573-3432 | Journal of autism and developmental disorders | Commitment to classroom model philosophy and burnout symptoms among high fidelity teachers implementing preschool programs for children with autism spectrum disorders. | Coman Drew, Alessandri Michael, Gutierrez Anibal, Novotny Stephanie, Boyd Brian, Hume Kara, Sperry Laurie, Odom Samuel | eng | null | Journal Article, Multicenter Study, Research Support, U.S. Gov't, Non-P.H.S. | null | IM | 22706583, 10.1007/s10803-012-1573-1, 3571656, 3804935, 16496206, 14714928, 16467905, 19937103 | Teacher commitment to classroom model philosophy and burnout were explored in a sample of 53 teachers implementing three preschool models at high levels of fidelity for students with autism: Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH); Learning Experiences and Alternative Program for Preschoolers and Their Parents (LEAP); and high quality special education programs (HQSEP's). Relative to the other groups, LEAP teachers reported significantly higher levels of commitment to LEAP philosophy while TEACCH teachers did not report significantly higher commitment levels to TEACCH philosophy. Teachers in HQSEP's reported similar levels of commitment to TEACCH and LEAP. Burnout was also low to moderate in this sample relative to normative data. Implications for school districts and teachers are discussed. | Adult, Burnout, Professional, Child, Child Development Disorders, Pervasive, Child, Preschool, Education, Special, Faculty, Female, Humans, Male, Professional Competence, Schools, Students, Surveys and Questionnaires | null |
22,706,584 | 2013-06-25 | 2021-10-21 | 1432-1041 | European journal of clinical pharmacology | Case series: paradoxical action of domperidone leads to increased vomiting. | Pozzi Marco, Strazzer Sandra, Locatelli Federica, Galbiati Sara, Formica Francesca, Maestri Luciano, Clementi Emilio, Radice Sonia | eng | null | Case Reports, Letter, Research Support, Non-U.S. Gov't | Domperidone | IM | 22706584, 10.1007/s00228-012-1324-4, 17488253, 18988693, 21895878 | null | Child, Child, Preschool, Domperidone, Enteral Nutrition, Female, Humans, Infant, Male, Vomiting | null |
22,706,586 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | No Longer Bound by Stigma. | Mattox Rhonda | eng | null | Journal Article | null | null | 22706586, 99708, 10.1176/appi.ajp.2007.07101580 | null | null | null |
22,706,587 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Dr. Keller Replies. | null | eng | null | Journal Article | null | null | 22706587, 99753, 10.1176/appi.ajp.2008.07121958r | null | null | null |
22,706,588 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Dr. Litz Replies. | null | eng | null | Journal Article | null | null | 22706588, 99756, 10.1176/appi.ajp.2007.07121853r | null | null | null |
22,706,585 | 2013-06-25 | 2022-12-07 | 1432-1041 | European journal of clinical pharmacology | Drug-drug interaction of rabeprazole and clopidogrel in healthy Chinese volunteers. | Wu Jia, Jia Li-Tao, Shao Li-Ming, Chen Jia-Min, Zhong Dan-Dan, Xu Song, Cai Jian-Ting | eng | null | Controlled Clinical Trial, Journal Article | 2-Pyridinylmethylsulfinylbenzimidazoles, Platelet Aggregation Inhibitors, Proton Pump Inhibitors, Rabeprazole, Clopidogrel, Aryl Hydrocarbon Hydroxylases, CYP2C19 protein, human, Cytochrome P-450 CYP2C19, Ticlopidine | IM | 22706585, 10.1007/s00228-012-1329-z, 19081411, 21247223, 19464402, 18786491, 20533345, 22050009, 22364155, 20102352, 15258107, 18836135, 19176635, 18303127, 19781742, 21262992, 19350116, 16772608, 20811753, 21357821, 18829199, 21544314, 18532997, 19258584, 22313038, 11474773, 20978260, 17900275, 19933932, 21511216, 20206794, 21170003, 19706858, 18323861, 18206732, 20133213, 16260639 | This study was aimed to determine the impact of rabeprazole (RBRZ) on the antiplatelet efficacy of clopidogrel (CPG) in healthy Chinese volunteers, and further to predict the effect of CYP2C19 genetic polymorphism on the efficacy of rabeprazole and clopidogrel. | 2-Pyridinylmethylsulfinylbenzimidazoles, Aryl Hydrocarbon Hydroxylases, Asian People, Clopidogrel, Cross-Over Studies, Cytochrome P-450 CYP2C19, Drug Interactions, Female, Genotype, Humans, Male, Platelet Aggregation, Platelet Aggregation Inhibitors, Polymorphism, Genetic, Proton Pump Inhibitors, Rabeprazole, Ticlopidine | null |
22,706,589 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | null | null | eng | null | Journal Article | null | null | 22706589, 99767, 10.1176/appi.ajp.2008.165.4.540 | null | null | null |
22,706,591 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Transgenic and Knockout Models of Neuropsychiatric Disorders. | null | eng | null | Journal Article | null | null | 22706591, 99775, 10.1176/appi.ajp.2008.07121848 | null | null | null |
22,706,590 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, Second Edition. | null | eng | null | Journal Article | null | null | 22706590, 99771, 10.1176/appi.ajp.2007.07121846 | null | null | null |
22,706,592 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Biomedical Ethics: A Multidisciplinary Approach to Moral Issues in Medicine and Biology. | null | eng | null | Journal Article | null | null | 22706592, 99779, 10.1176/appi.ajp.2007.07121891 | null | null | null |
22,706,593 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | Growing Up With Autism: Working With School-Age Children and Adolescents. | null | eng | null | Journal Article | null | null | 22706593, 99780, 10.1176/appi.ajp.2007.07121924 | null | null | null |
22,706,594 | null | 2019-11-20 | 1535-7228 | The American journal of psychiatry | null | null | eng | null | Journal Article | null | null | 22706594, 99782, 10.1176/appi.ajp.2008.165.4.544 | null | null | null |
22,706,596 | 2015-01-13 | 2016-11-25 | 1438-1435 | Emergency radiology | Musculoskeletal: what is different in children? Sixteen-month-old child falls and then does not want to walk. | Swischuk Leonard E | eng | null | Case Reports, Journal Article | null | IM | 22706596, 10.1007/s10140-012-1057-9 | null | Accidental Falls, Diagnosis, Differential, Humans, Infant, Male, Radiography, Tibial Fractures | null |
22,706,597 | 2012-12-10 | 2021-10-21 | 2210-7711 | International journal of clinical pharmacy | WHO guidelines for treatment of tuberculosis: the missing links. | Atif Muhammad, Sulaiman Syed Azhar Syed, Shafie Asrul Akmal, Ali Irfhan, Hassali Mohamed Azmi, Saleem Fahad | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antitubercular Agents, Histamine Antagonists | IM | 22706597, 10.1007/s11096-012-9657-8, 10444232, 1977782, 19967002, 17278655, 19224645, 22095153, 7718851, 15130027, 9011581, 2568530, 10354256, 8758132, 10335901, 6794821, 24826012, 15496227, 15686814, 10599020, 16153480 | Worldwide, the treatment of tuberculosis is based on evidence-based guidelines developed by the World Health Organization (WHO) for national tuberculosis programs. However, the importance of health related quality of life, the adequate management of side effects associated with antituberculosis drugs and the elaboration of tuberculosis treatment outcome categories are a few issues that need to be addressed in forthcoming WHO guidelines for the treatment of tuberculosis. | Antitubercular Agents, Exanthema, Guidelines as Topic, Histamine Antagonists, Humans, Pruritus, Quality of Life, Treatment Outcome, Tuberculosis, World Health Organization | null |
22,706,598 | 2012-10-26 | 2012-06-19 | 1361-6528 | Nanotechnology | Numerical and analytical evaluations of the sensing sensitivity of waveguide mode in one-dimensional metallic gratings. | Lei Dang Yuan, Wan Jones T K, Ong Hock Chun | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Metals | IM | 22706598, 10.1088/0957-4484/23/27/275501 | We study numerically and analytically the refractive index sensing sensitivities of surface plasmon (S(SP)) and waveguide (S(WG)) modes arising from one-dimensional Au gratings. By using rigorous coupled wave analysis, we find that while S(SP) is mainly controlled by the periodicity of the grating, the shape of the groove governs S(WG). As a result, it is possible to increase S(WG) to 1000 nm/RIU and figure of merit to 24 by tailoring the height and width of the groove. Finally, a simple analytical expression is derived to describe S(WG) and it agrees well with the numerical data. This easy-to-use expression not only reveals the origin of waveguide mode sensitivity, but also provides useful guidance for the theoretical design and experimental realization of high-sensitivity metallic-gratings-based biosensors. | Computer Simulation, Equipment Design, Equipment Failure Analysis, Metals, Models, Chemical, Nanoparticles, Refractometry, Surface Plasmon Resonance | null |
22,706,599 | 2013-05-03 | 2021-10-21 | 1432-1440 | Journal of molecular medicine (Berlin, Germany) | MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma. | Lynam-Lennon Niamh, Reynolds John V, Marignol Laure, Sheils Orla M, Pidgeon Graham P, Maher Stephen G | eng | null | Journal Article, Research Support, Non-U.S. Gov't | H2AX protein, human, Histones, MIRN31 microRNA, human, MicroRNAs | IM | 22706599, 10.1007/s00109-012-0924-x, 19549910, 16299786, 17242205, 15814658, 16061663, 18172293, 14697198, 22184287, 19524507, 17457163, 16997163, 20826792, 15902269, 20463022, 12802286, 19474385, 12115792, 19922656, 19801928, 18056433, 20179198, 18196926, 8752302, 19141645, 10803833, 18668526, 19242066, 20679741, 19949546, 18242245, 14630535, 8194005, 21128793, 18025253 | Chemoradiation therapy (CRT) prior to surgery is increasingly the standard of care for locally advanced oesophageal cancer. Radiation therapy is important for local tumour control; however, tumour resistance to radiation is a substantial clinical problem. The mechanism(s) of radioresistance are still poorly understood, however, mounting evidence supports a role for microRNA (miRNA) in modulating key cellular pathways mediating response to radiation. Global miRNA profiling of an established isogenic model of radioresistance in oesophageal adenocarcinoma demonstrated a significant downregulation of miR-31 in radioresistant cells, both basally and in response to radiation. Ectopic re-expression of miR-31 significantly re-sensitised radioresistant cells to radiation. miR-31 was demonstrated to alter the expression of 13 genes involved in DNA repair, which is a critical cellular defence against radiation-induced DNA damage. In oesophageal tumours, miR-31 expression was significantly reduced in patients demonstrating poor histomorphologic response to neoadjuvant CRT, whilst expression of the miR-31-regulated DNA repair genes was significantly increased. Our data suggest a possible mechanism for resistance to CRT, potentially via enhanced DNA repair. This study demonstrates, for the first time, a role for miR-31 in modulating radioresistance and highlights the need for further study investigating the potential role of miR-31 as both a predictive marker of response and a novel therapeutic agent with which to enhance the efficacy of radiation therapy. | Adenocarcinoma, Blotting, Western, Cell Line, Tumor, Esophageal Neoplasms, Gene Expression Regulation, Neoplastic, Histones, Humans, MicroRNAs, Radiation Tolerance | null |
22,706,600 | 2013-05-03 | 2021-10-21 | 1432-1440 | Journal of molecular medicine (Berlin, Germany) | Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine. | Pickert Geethanjali, Myrczek Thekla, Rückert Steven, Weigert Andreas, Häussler Annett, Ferreirós Nerea, Brüne Bernhard, Lötsch Jörn, Tegeder Irmgard | eng | R01 NS058870 (NINDS NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't | 5-dehydro-3-deoxy-D-arabino-heptulosonic acid-7-phosphate, Sugar Acids, Morphine, GTP Cyclohydrolase | IM | 22706600, 10.1007/s00109-012-0927-7, 12384231, 20599472, 19745186, 19146917, 20147620, 10727395, 20630656, 21899601, 18515178, 20053925, 19959292, 19414201, 20643956, 7531790, 11512037, 21436345, 12620371, 16297905, 16282548, 12690049, 19907420, 14990791, 22753274, 18256252, 19500901, 7512709, 18445052, 21281309, 16271434, 19299781, 19284878, 18716216, 18374612, 19851158, 12003349, 16109402, 17913925, 17996205, 9761115, 17994223, 20335463, 10640309, 20217325, 18320364, 18719619, 17057711, 17048971, 10422774, 9920651 | Noncoding polymorphisms of the GTP cyclohydrolase gene (GCH1) reduce the risk for chronic pain in humans suggesting GCH1 inhibitors as analgesics. We assessed the effects of the GCH1 inhibitor diaminohydroxypyrimidine (DAHP) on nociception and inflammation in a mouse melanoma and a sarcoma cancer pain model, and its co-effects with morphine in terms of analgesic efficacy and respiratory depression. GCH1 inhibition did not reduce the tumor-evoked nociceptive hypersensitivity of the tumor-bearing paw. However, DAHP reduced melanoma- and sarcoma-evoked systemic hyperalgesia as determined by analyzing contralateral paws. GCH1 inhibition increased the inflammatory edema and infiltration with polymorphonuclear leukocytes surrounding the tumor but reduced the tumor-evoked microglia activation in the spinal cord suggesting that an increase of the local immune attack against the tumor may avoid general pain hypersensitivity. When used in combination with morphine at high or low doses, GCH1 inhibition increased and prolonged the analgesic effects of the opioid. It did not, however, increase the respiratory depression caused by morphine. Conversely, the GCH1-product, tetrahydrobiopterin, caused hyperalgesia, antagonized antinociceptive effects of morphine, and aggravated morphine-evoked respiratory depression, the latter mimicked by a cGMP analog suggesting that respiratory effects were partly mediated through the BH4-NO-cGMP pathway. The observed effects of GCH1 inhibition in the tumor model and its enhancement of morphine-evoked antinociception without increase of morphine toxicity suggest that GCH1 inhibitors might be useful as co-therapeutics for opioids in cancer patients. | Animals, GTP Cyclohydrolase, Male, Melanoma, Mice, Mice, Inbred C57BL, Morphine, Neoplasms, Pain, Sarcoma, Sugar Acids | null |
22,706,601 | 2012-12-21 | 2021-10-21 | 1543-706X | In vitro cellular & developmental biology. Animal | Establishment and characterization of a cell line from the mosquito Culex tritaeniorhynchus (Diptera: Culicidae). | Kuwata Ryusei, Hoshino Keita, Isawa Haruhiko, Tsuda Yoshio, Tajima Shigeru, Sasaki Toshinori, Takasaki Tomohiko, Kobayashi Mutsuo, Sawabe Kyoko | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Electron Transport Complex IV | IM | 22706601, 10.1007/s11626-012-9520-1, 7463489, 21697481, 21379333, 9326640, 903925, 18588503, 19116041, 5458787, 17872529, 4869110, 21191029, 2267971, 21049014, 23155353, 21940408, 15891138, 21049065, 22172307, 690610, 17846036, 19578437, 5142324, 3447015, 21099089, 18501400, 5501238, 19265532, 2280394, 1238028, 21750744, 19214215, 15166447, 19047642, 19067628, 7169234, 15583140, 5338625, 5048073, 16253374, 5360492, 28561359, 5019214, 10854169, 5545029, 12693860, 10206988, 18366655, 12584335, 21943222 | We established a continuous cell line from the embryo of the mosquito Culex tritaeniorhynchus Giles (Diptera: Culicidae), a known major vector of the Japanese encephalitis virus (family Flaviviridae, genus Flavivirus) in Asia. The cell line, designated NIID-CTR, was serially subcultured in VP-12 medium supplemented with 10 % heat-inactivated fetal bovine serum (FBS). It continued to grow for more than 60 passages over a 750-d period. The NIID-CTR cell line mainly comprised two morphologically distinct types of cells with adhesive properties: spindle-shaped and round cells. Most of the NIID-CTR cells at the 45th passage were diploid (2n = 6). The growth kinetics of the NIID-CTR cells was significantly affected by the FBS concentration in the medium. The population doubling time of the NIID-CTR cells was 20 h in the presence of 10 % FBS and 76 h in its absence. The DNA sequence of the mitochondrial cytochrome oxidase I gene confirmed that the NIID-CTR cell line was derived from C. tritaeniorhynchus. The cells were highly susceptible to Japanese encephalitis and Dengue viruses, thus providing a valuable tool for the study of mosquito-borne flaviviruses. | Animals, Cell Culture Techniques, Cell Line, Culex, Dengue Virus, Electron Transport Complex IV, Encephalitis Virus, Japanese, Molecular Sequence Data, Primary Cell Culture, Sequence Analysis, DNA | null |
22,706,602 | 2012-12-21 | 2021-10-21 | 1543-706X | In vitro cellular & developmental biology. Animal | Fig leaf extract and its bioactive compound psoralen induces skin darkening effect in reptilian melanophores via cholinergic receptor stimulation. | Meitei Keisham V, Ali Sharique A | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Melanins, Plant Extracts, Receptors, Cholinergic, Ficusin, Acetylcholine | IM | 22706602, 10.1007/s11626-012-9521-0, 19121820, 16912692, 6286871, 2127639, 992813, 21880033, 21391886, 9972321, 16937536, 4388349, 20863173, 17346754, 6141872, 3862124, 20351802, 8714764, 7128806, 16763548 | null | Acetylcholine, Animals, Ficus, Ficusin, Lizards, Melanins, Melanophores, Plant Extracts, Receptors, Cholinergic, Skin, Skin Pigmentation | null |
22,706,603 | 2012-11-19 | 2023-01-20 | 1460-4744 | Chemical Society reviews | Understanding prebiotic chemistry through the analysis of extraterrestrial amino acids and nucleobases in meteorites. | Burton Aaron S, Stern Jennifer C, Elsila Jamie E, Glavin Daniel P, Dworkin Jason P | eng | null | Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review | Amino Acids, Nucleotides | IM | 22706603, 10.1039/c2cs35109a | The discoveries of amino acids of extraterrestrial origin in many meteorites over the last 50 years have revolutionized the Astrobiology field. A variety of non-terrestrial amino acids similar to those found in life on Earth have been detected in meteorites. A few amino acids have even been found with chiral excesses, suggesting that meteorites could have contributed to the origin of homochirality in life on Earth. In addition to amino acids, which have been productively studied for years, sugar-like molecules, activated phosphates, and nucleobases have also been determined to be indigenous to numerous meteorites. Because these molecules are essential for life as we know it, and meteorites have been delivering them to the Earth since accretion, it is plausible that the origin(s) of life on Earth were aided by extraterrestrially-synthesized molecules. Understanding the origins of life on Earth guides our search for life elsewhere, helping to answer the question of whether biology is unique to Earth. This tutorial review focuses on meteoritic amino acids and nucleobases, exploring modern analytical methods and possible formation mechanisms. We will also discuss the unique window that meteorites provide into the chemistry that preceded life on Earth, a chemical record we do not have access to on Earth due to geologic recycling of rocks and the pervasiveness of biology across the planet. Finally, we will address the future of meteorite research, including asteroid sample return missions. | Amino Acids, Evolution, Chemical, Extraterrestrial Environment, Mass Spectrometry, Meteoroids, Nucleotides, Origin of Life | null |
22,706,604 | 2013-05-29 | 2021-10-21 | 1559-0100 | Endocrine | The effect of chronic immobilization stress on leptin signaling in the ovariectomized (OVX) rat. | Larco Darwin O, Cruthirds Danette F, Weiser Michael J, Handa Robert J, Wu T John | eng | MH082679 (NIMH NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S. | Drug Implants, Leptin, STAT3 Transcription Factor, Socs3 protein, rat, Stat3 protein, rat, Suppressor of Cytokine Signaling 3 Protein, Suppressor of Cytokine Signaling Proteins, Estradiol, Corticosterone | IM | 22706604, 10.1007/s12020-012-9716-x, 18325991, 10447781, 20674948, 17454160, 10415366, 20708081, 11720251, 18334610, 11753591, 16457953, 3485449, 11181953, 1961129, 10878498, 1584842, 9002549, 1849215, 19015004, 12697721, 12127097, 9072828, 15271881, 17956983, 7584987, 10702625, 12721502, 17195839, 17543357, 16181647, 15820527, 8857608, 11514111, 7574495, 19440072, 12510013, 18673202, 12062315, 8592520, 10516478, 10514492, 18241818, 1633277, 11095962, 8584938, 19074580, 15059958, 11124586, 15160484, 9660946, 12374466, 10799542, 15682923, 17506645, 16452668, 18164702, 18502406 | Previous studies have shown that both 17β-estradiol (E2) treatment and chronic stress may attenuate post-OVX weight gain in the female rat. However, the interaction between E2 and stress is unclear. This study examined the effect of E2 treatment and chronic immobilization stress on body weight. Adult OVX Sprague-Dawley rats were randomly assigned to one of four treatment groups in a 2X2 factorial design examining hormone treatment [vehicle (VEH) or E2, sc] and stress (no stress vs stress 60 min/day for 22 days). After 22 days, E2 significantly inhibited weight gain and food intake in OVX rats. In contrast, chronic stress reduced body weight only in control OVX animals but did not affect food intake. E2 reduced circulating leptin levels in non-stressed animals, but not in animals subjected to chronic immobilization. Western blot analysis indicated that E2 treatment increased leptin receptor (Ob-Rb) expression in the medial basal hypothalamus (MBH); however, this treatment also increased suppressor of cytokine signaling 3 (SOCS3), which is an inhibitor of leptin signaling. Chronic immobilization stress blunted the E2-induced increase in Ob-Rb and SOCS3 levels. These results suggest that chronic stress counteracts E2 effects on leptin signaling in the MBH without altering body weight. | Animals, Blotting, Western, Body Weight, Brain Chemistry, Corticosterone, Drug Implants, Eating, Enzyme-Linked Immunosorbent Assay, Estradiol, Female, Hypothalamo-Hypophyseal System, Hypothalamus, Middle, Leptin, Ovariectomy, Pituitary-Adrenal System, Rats, Rats, Sprague-Dawley, Restraint, Physical, STAT3 Transcription Factor, Signal Transduction, Stress, Psychological, Suppressor of Cytokine Signaling 3 Protein, Suppressor of Cytokine Signaling Proteins | null |
22,706,605 | 2013-05-29 | 2022-03-30 | 1559-0100 | Endocrine | Management of adjuvant mitotane therapy following resection of adrenal cancer. | Terzolo M, Ardito A, Zaggia B, Laino F, Germano A, De Francia S, Daffara F, Berruti A | eng | null | Journal Article, Review | Antineoplastic Agents, Hormonal, Mitotane | IM | 22706605, 10.1007/s12020-012-9719-7, 21386792, 22311173, 21470991, 8490842, 10679640, 18824557, 20567001, 7115060, 21706269, 18842984, 18438168, 10852456, 22048971, 19912359, 16551731, 17554118, 17881760, 17554125, 20668036, 11745214, 2574647, 2913342, 11572030, 16172199, 20596677, 20026647, 19851811, 9426440, 19667279, 18143915, 1455321, 8180029, 9394846, 15898346, 11572033 | Whenever adrenal cancer (ACC) is completely removed we should face the dilemma to treat by means of adjuvant therapy or not. In our opinion, adjuvant mitotane is the preferable approach in most cases because the majority of patients following radical removal of an ACC have an elevated risk of recurrence. A better understanding of factors that influence prognosis and response to treatment will help in stratifying patients according to their probability of benefiting from adjuvant mitotane, with the aim of sparing unnecessary toxicity to patients who are likely unresponsive. However, until significant advancements take place, we have to deal with uncertainty using our best clinical judgement and personal experience in the clinical decision process. In the present paper, we present the current evidence on adjuvant mitotane treatment and describe the management strategies of patients with ACC after complete surgical resection. We acknowledge the limit that most recommendations are based on personal experience rather than solid evidence. | Adrenal Gland Neoplasms, Antineoplastic Agents, Hormonal, Case Management, Chemotherapy, Adjuvant, Combined Modality Therapy, Disease-Free Survival, Humans, Mitotane, Prognosis | null |
22,706,606 | 2012-11-01 | 2018-12-01 | 1556-1380 | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer | More emphasis on resection rates! | Strand Trond-Eirik | eng | null | Editorial, Comment | null | IM | 22706606, 10.1097/JTO.0b013e31825bdaf8, S1556-0864(15)33281-0 | null | Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Pneumonectomy, Postoperative Complications | null |
22,706,607 | 2012-11-01 | 2013-01-07 | 1556-1380 | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer | A novel EML4-ALK variant: exon 6 of EML4 fused to exon 19 of ALK. | Penzel Roland, Schirmacher Peter, Warth Arne | eng | null | Case Reports, Journal Article | EML4-ALK fusion protein, human, Oncogene Proteins, Fusion, RNA, Messenger | IM | 22706607, 10.1097/JTO.0b013e3182598af3, S1556-0864(15)33299-8 | Cytotoxic chemotherapy remains the mainstay of treatment for most patients with advanced disease. Recently, anaplastic lymphoma kinase (ALK) expression as a major target for successful treatment with ALK inhibitors was detected in a subset of non-small-cell lung carcinomas, usually as a result of echinoderm microtubule-associated protein-like 4 (EML4)-ALK rearrangements. Although the chromosomal breakpoint within the EML4 gene varied, the breakpoint within ALK was most frequently reported within intron 19 or rarely in exon 20. Therefore, the different EML4-ALK variants so far contain the same 3' portion of ALK starting with exon 20. | Adenocarcinoma, Aged, Carcinoma, Non-Small-Cell Lung, Exons, Female, Gene Rearrangement, Genetic Variation, Humans, Immunoenzyme Techniques, Lung Neoplasms, Oncogene Proteins, Fusion, Prognosis, RNA, Messenger, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction | null |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.