uniprot_id
string | protein_variant
string | VESM++
float64 | using_structure
int64 |
|---|---|---|---|
Q969Z0 | M1K | -12.45 | 1 |
Q969Z0 | M1R | -11.4 | 1 |
Q969Z0 | M1H | -13.4 | 1 |
Q969Z0 | M1E | -12.88 | 1 |
Q969Z0 | M1D | -14.05 | 1 |
Q969Z0 | M1N | -13.34 | 1 |
Q969Z0 | M1Q | -11.95 | 1 |
Q969Z0 | M1T | -11.62 | 1 |
Q969Z0 | M1S | -11.18 | 1 |
Q969Z0 | M1C | -13.51 | 1 |
Q969Z0 | M1G | -11.87 | 1 |
Q969Z0 | M1A | -10.84 | 1 |
Q969Z0 | M1V | -11.29 | 1 |
Q969Z0 | M1L | -10.91 | 1 |
Q969Z0 | M1I | -12.61 | 1 |
Q969Z0 | M1P | -11.69 | 1 |
Q969Z0 | M1Y | -14.14 | 1 |
Q969Z0 | M1F | -13.05 | 1 |
Q969Z0 | M1W | -13.49 | 1 |
Q969Z0 | A2K | -10.2 | 1 |
Q969Z0 | A2R | -9.25 | 1 |
Q969Z0 | A2H | -10.77 | 1 |
Q969Z0 | A2E | -9.89 | 1 |
Q969Z0 | A2D | -11.44 | 1 |
Q969Z0 | A2N | -10.43 | 1 |
Q969Z0 | A2Q | -10.06 | 1 |
Q969Z0 | A2T | -6.66 | 1 |
Q969Z0 | A2S | -6.69 | 1 |
Q969Z0 | A2C | -10.56 | 1 |
Q969Z0 | A2G | -8.21 | 1 |
Q969Z0 | A2V | -6.67 | 1 |
Q969Z0 | A2L | -8.07 | 1 |
Q969Z0 | A2I | -9.68 | 1 |
Q969Z0 | A2M | -8.34 | 1 |
Q969Z0 | A2P | -9.51 | 1 |
Q969Z0 | A2Y | -11.17 | 1 |
Q969Z0 | A2F | -9.57 | 1 |
Q969Z0 | A2W | -10.13 | 1 |
Q969Z0 | A3K | -8.76 | 1 |
Q969Z0 | A3R | -6.94 | 1 |
Q969Z0 | A3H | -8.22 | 1 |
Q969Z0 | A3E | -8.68 | 1 |
Q969Z0 | A3D | -9.72 | 1 |
Q969Z0 | A3N | -8.53 | 1 |
Q969Z0 | A3Q | -7.63 | 1 |
Q969Z0 | A3T | -4.84 | 1 |
Q969Z0 | A3S | -4.99 | 1 |
Q969Z0 | A3C | -7.78 | 1 |
Q969Z0 | A3G | -5.8 | 1 |
Q969Z0 | A3V | -4.39 | 1 |
Q969Z0 | A3L | -5.5 | 1 |
Q969Z0 | A3I | -7.6 | 1 |
Q969Z0 | A3M | -6.87 | 1 |
Q969Z0 | A3P | -7.48 | 1 |
Q969Z0 | A3Y | -9.02 | 1 |
Q969Z0 | A3F | -7.15 | 1 |
Q969Z0 | A3W | -7.83 | 1 |
Q969Z0 | H4K | -5.66 | 1 |
Q969Z0 | H4R | -3 | 1 |
Q969Z0 | H4E | -6.15 | 1 |
Q969Z0 | H4D | -6.99 | 1 |
Q969Z0 | H4N | -5.11 | 1 |
Q969Z0 | H4Q | -3.53 | 1 |
Q969Z0 | H4T | -4.02 | 1 |
Q969Z0 | H4S | -3.05 | 1 |
Q969Z0 | H4C | -4.33 | 1 |
Q969Z0 | H4G | -3.58 | 1 |
Q969Z0 | H4A | -2.81 | 1 |
Q969Z0 | H4V | -3.51 | 1 |
Q969Z0 | H4L | -3.09 | 1 |
Q969Z0 | H4I | -5.46 | 1 |
Q969Z0 | H4M | -4.99 | 1 |
Q969Z0 | H4P | -4.23 | 1 |
Q969Z0 | H4Y | -4.69 | 1 |
Q969Z0 | H4F | -4.46 | 1 |
Q969Z0 | H4W | -4.92 | 1 |
Q969Z0 | L5K | -10.74 | 1 |
Q969Z0 | L5R | -8.58 | 1 |
Q969Z0 | L5H | -9.39 | 1 |
Q969Z0 | L5E | -11.52 | 1 |
Q969Z0 | L5D | -12.63 | 1 |
Q969Z0 | L5N | -10.9 | 1 |
Q969Z0 | L5Q | -9.23 | 1 |
Q969Z0 | L5T | -7.29 | 1 |
Q969Z0 | L5S | -7.46 | 1 |
Q969Z0 | L5C | -7.37 | 1 |
Q969Z0 | L5G | -7.97 | 1 |
Q969Z0 | L5A | -6 | 1 |
Q969Z0 | L5V | -4.81 | 1 |
Q969Z0 | L5I | -6.23 | 1 |
Q969Z0 | L5M | -6.6 | 1 |
Q969Z0 | L5P | -8.98 | 1 |
Q969Z0 | L5Y | -9.11 | 1 |
Q969Z0 | L5F | -5.88 | 1 |
Q969Z0 | L5W | -7.53 | 1 |
Q969Z0 | V6K | -8.84 | 1 |
Q969Z0 | V6R | -6.42 | 1 |
Q969Z0 | V6H | -7.97 | 1 |
Q969Z0 | V6E | -9.65 | 1 |
Q969Z0 | V6D | -11.25 | 1 |
Proteome-wide VESM variant effect scores
This repository provides precomputed proteome-wide (UniProt, hg19, and hg38) variant-effect prediction scores using the latest VESM models developed in the paper "Compressing the collective knowledge of ESM into a single protein language model" by Tuan Dinh, Seon-Kyeong Jang, Noah Zaitlen and Vasilis Ntranos.
- Models: VESM, VESM1, VESM2, VESM3, VESM++ (available at https://huggingface.co/ntranoslab/vesm).
VESM1, VESM2 and VESM3 are individual protein language models based on ESM1b, ESM2-650m and ESM3. VESM is the average of VESM1 and VESM2 (sequence-only) and VESM++ is the ensemble of all three.
Please see the corresponding GitHub repo (https://github.com/ntranoslab/vesm) for more details.
License
The predictions of VESM, VESM1, and VESM2 are distributed under the MIT License. The VESM3 and VESM++ models are built with ESM3-Open (EvolutionaryScale), which is available under a non-commercial license agreement.
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