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CRD420250616527 | How do the metrics of heart rate variability (HRV), both in the time domain and frequency domain, vary in patients diagnosed with anorexia nervosa compared to healthy controls? Additionally, how are these variations related to the different stages of the disorder and to clinical outcomes, considering the measurement time? | Anorexia nervosa (AN) is a mental health disorder characterized by severe caloric restriction, primarily affecting adolescent females (lifetime prevalence up to 4%) and males (0.3%). It has the highest mortality rate among mental disorders, at 5%.Beyond significant weight loss, AN causes severe physical consequences due to malnutrition, including growth impairments, bone fragility, muscle weakness, neuroendocrine dysfunctions, and autonomic nervous system dysregulation, which can lead to cardiovascular complications and increased mortality. Inclusion Criteria:- Patients with anorexia nervosa based on standardized diagnostic criteria (DSM-5).- Participants in various phases of the disease, including acute, recovery, and post-recovery stages. The main exposure in this case will be the measurement of HRV and its parameters in patients with anorexia nervosa.Studies will be included that measure various HRV parameters, such as:- Time-domain measures: SDNN, RMSSD, pNN50.- Frequency-domain measures: LF, HF, LF/HF ratio Healthy controls who do not suffer from anorexia nervosa. | Exclusion Criteria:- Patients with other primary eating disorders (e.g., bulimia nervosa, binge eating disorder) without specific subgroup analysis for anorexia nervosa.- Studies including participants with comorbid conditions that could independently affect the outcomes (e.g., severe cardiovascular or endocrine disorders unrelated to anorexia nervosa). |
CRD42020203829 | We would like to answer two research questions: 1) Is there evidence for parenting behaviors predicting later children’s effortful control, for children’s effortful control predicting later parenting behaviors, and/or longitudinal and transactional relations between them? 2) If heterogeneity exists among relations between parenting behaviors and children’s effortful control, will the variance be explained by moderators, such as sample characteristics, types of effortful control and parenting behaviors, aspects of study design, and publication status of the literature? | We focus on children's effortful control. which refers to a trait-level top-down self-regulation that involves attentional focusing, attentional shifting, inhibition and activation control of behavior, emotion regulation, and basic level cognitive control when it is used for self-regulation (Nigg, 2017; Rothbart, 2011). Effortful control has been found to predict various types of developmental outcomes related to children' well-being and mental health, such as depression, anxiety, or behavioral problems (Eisenberg et al., 2016). | null |
CRD42025646217 | What are the barriers, feasibility, and challenges of implementing community-based palliative care for patients with cancer in India, as reported in observational and interventional studies? | This systematic review focuses on palliative care, a specialized form of healthcare aimed at improving the quality of life for patients with serious, life-limiting conditions, particularly those with cancer. Palliative care addresses not only the physical aspects of patient care, such as pain relief and symptom management, but also psychological, social, and spiritual needs. It involves a holistic approach to alleviate suffering, enhance comfort, and provide support for patients and their families during the end-of-life process.
In India, the integration and implementation of palliative care face significant barriers, including limited healthcare resources, a shortage of trained professionals, and cultural and societal challenges. This review examines the feasibility, challenges, and barriers to delivering community-based palliative care in India, specifically from the perspective of nursing care, and evaluates its impact on patient and caregiver satisfaction, cost-effectiveness, and outcomes such as morbidity and mortality. | null |
CRD42025636888 | The quality of the literatures are evaluated, whether there are large heterogeneity, whether there are publication biases and reporting biases in the included literatures, and the statistical methods were clarified. | Metabolic syndrome is a complex metabolic disorder characterized by the aggregation of multiple metabolic abnormalities such as obesity, hypertension, hyperglycemia, and dyslipidemia in the same individual. This state greatly increases the risk of developing chronic diseases such as cardiovascular disease and diabetes. Metabolic syndrome not only affects the physical health of patients and reduces the quality of life, but also may bring heavy economic burden to families and society. Metabolic syndrome not only affects the physical health of patients and reduces the quality of life, but also may bring heavy economic burden to families and society. Therefore, it is important to actively prevent and treat metabolic syndrome, improve lifestyle, control diet, and increase physical exercise to maintain individual health. | null |
CRD42023434372 | What is the effectiveness of receiving polygenic risk information for cardiovascular disease in risk factor medication, and what are the associated behavioural and psychological impacts in individuals with or without cardiovascular disease? | Cardiovascular disease, coronary artery disease, polygenic risk score (PRS), genetic risk score, genetic risk This review will consider studies that include participants who are adults (defined as 18 years and over) of either sex, any age or ethic group, with and without evidence of CVD. This review will consider studies that evaluate the effectiveness of receiving individual’s PRS for CVD or CVD-related gene results. Typically, we expect the intervention to consist of the individual being presented with the PRS result and an explanation being given detailing what the score means and the implication this has for their heart health and behaviours. This review will consider studies that compare the intervention to two control conditions: one where no risk information is provided, and another where risk information derived from traditional risk factors, such as age, smoking, diet, hypertension, diabetes, and family history. | null |
CRD42022328170 | 1. What is the level of mental health literacy in secondary school teachers?
2. What are the existing interventions for improving secondary school teachers’ mental health literacy (MHL) and is there any evidence of effectiveness? | Secondary school teacher or staff mental health literacy | null |
CRD42023434712 | 1. What is the mental health experience of individuals with post-covid fatigue, and what is the severity of their mental health difficulties? 2. What are the techniques and content used in interventions which are effective in improving mental health outcomes for individuals experiencing post-covid fatigue? | The condition being studied is post-Covid fatigue, which is characterised by fatigue symptoms which persist after 12 or more weeks following Covid-19 infection, and are not explained by another diagnosis (NICE Covid-19 rapid guidelines). | null |
CRD420250650227 | What conditions are pharmacist-led in general practises and its impact? What is the patient's perspective of pharmacist-led services in general practice? | Services being provided by pharmacists in general practice Inclusion: any service provided by registered pharmacists in general practice from 2015 to 2024, international studies included, GP and patient perceptions, medication reviews, educating patients or GPs, independent prescribing, any specific clinics (hypertension, diabetes, mental health etc) Exclusion: any services provided in community or hospital settings, pharmacist's providing traditional dispensing services, studies prior to 2015, health economics, pharmacist perceptions Intervention - pharmacists providing services in general practiceExposure - what services are commonly pharmacist-led in general practice Not applicable | null |
CRD42022324338 | 1. How is social cognition associated with violence? | Social Cognition in Violence | null |
CRD42023452418 | What is the relationship between neuroticism and anxiety among individuals during the COVID-19 pandemic? | The systematic review focuses on investigating the relationship between neuroticism and anxiety in the context of the COVID-19 pandemic. Neuroticism is a personality trait characterized by emotional instability, a tendency to experience negative emotions, and heightened sensitivity to stressors. Anxiety, on the other hand, is a psychological state characterized by feelings of worry, fear, and apprehension. | null |
CRD420250629794 | 1) How is spirituality in schizophrenia patients? 2) Is spirituality a coping mechanism for schizophrenia, 3) What is the relationship between spirituality and schizophrenia recovery? | (1) studies comprising schizophrenia patients, (2) related to spiritual experiences and descriptions from the first-person perspective, Schizophrenia patients related to spiritual experiences and descriptions from the first-person perspective, The inclusion criteria included (1) studies comprising schizophrenia patients, (2) related to spiritual experiences and descriptions from the first-person perspective, (3) journal publications from the years 2019 to 2023, (4) qualitative or quantitative study, and (5) published in English. The exclusion comprised 1) article descriptions from the perspectives of nurses, mental health staff, caregivers, or psychotherapists, and 2) written in the form of reviews, conference proceedings, protocols, and theses/dissertations. article descriptions from the perspectives of nurses, mental health staff, caregivers, or psychotherapists, and 2) written in the form of reviews, conference proceedings, protocols, and theses/dissertations. | null |
CRD42023384630 | This systematic review aims to summarize and clarify the existing evidence concerning the relationship between burnout and employee silence and voice outcomes (Table 1. PICOs). There are three objectives:1. To examine whether burnout is associated with employee silence outcomes (e.g., frequency of reported silence behaviors, employee silence beliefs);2. To examine whether burnout is associated with employee voice outcomes (e.g., frequency of reported voice behaviors, employee voice beliefs)3. To examine the direction of the relationship between burnout and employee silence outcomes and between burnout and employee voice outcomes.4. To examine whether the associations between burnout and employee silence outcomes and employee voice outcomes are moderated by study level factors (e.g. full versus abbreviated measure of burnout; gender of participants, industry/sector/occupation). | Burnout is a psychological syndrome that involves a prolonged response to chronic emotional and interpersonal stressors on the job (Maslach et al., 2006). The three key dimensions of job burnout are exhaustion, feelings of cynicism/depersonalization, and a sense of professional inefficacy/lack of accomplishment (Leiter & Maslach, 2016). Employee silence behavior is likely to involve high levels of emotional and cognitive self-regulation, as the employee needs to engage in an ongoing suppression that may be exacerbated by rumination outside of work, leaving less time for recovery (Sonnentag & Bayer, 2005). It is expected that increased levels of burnout will be associated with more frequent or intense experiences of employee silence. The process of burnout gradually resulting in employee silence suggests the potential of a downward loss spiral such as that described in the Job-Demands Resources (JDR) Model (Bakker & Demerouti, 2017); these spiral effects are in line with the feedback loop approach, whereby burnout reinforces silence and silence reinforces burnout. Thus, the review aims to summarize and clarify the existing evidence concerning the relationship between burnout and employee silence and voice outcomes. The search will be restricted to the general working population (employees) and all studies should have collected data from participants who are identified as either staff, workers or employees of an organization. Burnout will be the exposure of interest operationalized as scores on burnout measures (e.g. Maslach Burnout Inventory) and the scores of burnout dimensions where available (e.g., Emotional Exhaustion, Cynicism and Lack of accomplishment according to the Maslach Burnout Inventory). | null |
CRD42023415470 | The primary research question is ‘What are the psychological feelings of non-suicidal self-injury adolescents? ’
(1) The research objects are adolescents with non-suicidal self-injury behavior; (2) The research content is the psychological experience and feelings of adolescents after non-suicidal self-injury; (3) The research situation is adolescents who have non-suicidal self-injury (4) The type of research is qualitative research or the qualitative research part of mixed research, and the research methods adopt phenomenological research, grounded theory, ethnography, ethnographic research, etc. | Non-suicidal self-injury (NSSI) refers to direct, repeated and socially unacceptable self-injury to bodily tissues without suicidal intent , including cuts, scratches, impacts, and burns, and is a common, significant and highly public health concern. NSSI has a high prevalence in the adolescent population, with a lifetime prevalence of 22.0% and an overall 12-month prevalence of 23.2% for NSSI in a global non-clinical adolescent sample from 2010 to 2021.NSSI in adolescence may have lasting and far-reaching effects, and it is associated with a variety of psychological and behavioral disorders that seriously endanger the physical and mental health of adolescents, as well as being an important risk factor for suicide attempts and suicides , while also placing a large burden on families and society.This research summarizes the qualitative research on the psychological experience of non-suicidal self-injury in adolescents at home and abroad through a Meta-integration approach, aiming to improve the knowledge of non-suicidal self-injury among healthcare professionals and provide a basis for targeted psychological interventions by clinical healthcare professionals. | null |
CRD420250631495 | Population (P): Individuals diagnosed with Alzheimer’s disease (AD), Parkinson’s disease (PD), or adults assessed for cognitive domains.Intervention (I): Infection with the parasite Toxoplasma gondii, evaluated using IgG, IgM, or PCR tests.Comparison (C): Control groups without infection.Outcome (O): The impact of Toxoplasma gondii infection on cognitive decline, including cognitive flexibility, memory, verbal fluency, and its association with AD or PD. | Cognitive function ; Toxoplasmosis; Alzheimer's Disease The study focuses on the cognitive and neurological implications of Toxoplasma gondii infection, particularly its association with cognitive decline (including memory, cognitive flexibility, verbal fluency) and its potential role in neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The study includes individuals diagnosed with Alzheimer’s disease (AD) or Parkinson’s disease (PD) and adults of various ages assessed for cognitive domains. These participants were evaluated for Toxoplasma gondii infection using diagnostic methods such as IgG, IgM, or PCR tests. The primary exposure is infection with Toxoplasma gondii. This is assessed through serological markers (IgG and IgM antibodies) and molecular diagnostic methods (PCR). The study investigates the effects of both acute (IgM) and chronic (IgG) infections on cognitive functions and their potential link to neurodegenerative diseases like Alzheimer’s (AD) and Parkinson’s (PD). PICO tags selected: Healthcare services; Mental Health Care Education; Assessment Using Alzheimer's Disease Assessment Scale; Placebo The control groups consist of individuals without Toxoplasma gondii infection, determined by negative results in IgG, IgM, or PCR tests. These groups are used to compare cognitive outcomes and the prevalence of infection relative to the infected participants. | null |
CRD420250648494 | 1) What is the relationship between sexual violence victimization and self-compassion? 2) What are the mental health correlates of self-compassion among survivors of sexual violence victimization at various points in the lifespan (adulthood, childhood)? | Sexual Assault; Compassion The relationship between sexual violence and self-compassion clinical and nonclinical samples of sexual assault survivors, no other exclusion criteria based on population None. Articles must include at least one measure of sexual victimization across the lifespan and one measure of self-compassion. This may include both correlational/cross-sectional and intervention studies | null |
CRD420250602383 | How effective are virtual reality interventions for childhood anxiety and anxiety disorders? | Childhood; Anxiety Disorder; Anxiety; Virtual Reality; Cognitive Behavioral Therapy; Adolescence Childhood Anxiety and Anxiety Disorders. Children (under 18 years of age) with anxiety disorders and childhood anxiety Virtual Reality; Cognitive Behavioral Therapy; Behavioral Therapy PICO tags selected: Usual Care; Active control; Waiting list control | Adults (18 years and above) Studies on the efficacy of VRET on medical pediatric prrocedures will be excluded. |
CRD42021282629 | How does yoga practice affect the post-training recovery from physiological fatigue in football players in comparison to routine recovery methods? | Physiological Recovery from Fatigue after Training in Football Players | null |
CRD42023411677 | Is there any evidence based and clinically pragmatic method to assess testamentary capacity? | Testamentary Capacity | null |
CRD42022312717 | Is the composition of time spent in movement behaviours (sleep, sedentary behaviour/screen time, physical activity) associated with mental health? | Mental health outcomes in non-clinical adult or child populations in relation to 24-hour movement behaviours. | null |
CRD420251001903 | To explore the effects of traditional Chinese medicine formulas in treating depression by regulating the gut microbiota and the microbiota - gut - brain axis through meta - analysis. | meet the diagnostic criteria for depression;The patient is conscious and cooperative. Traditional Chinese Medicine; Herbal medicine PICO tags selected: Usual Care case - control study | Those with comorbid mental disorders; patients with allergic constitution; those who have taken medications for mental disorders or antibiotics within the past two weeks; and those with severe gastrointestinal diseases animal experimental study |
CRD42025635936 | "What is the efficacy of digital therapeutics in improving mental health outcomes, patient engagement, and adherence in psychiatric nursing interventions across different patient populations?" | This systematic review focuses on the use of digital therapeutics (DTx) in the domain of psychiatric nursing for the management and treatment of mental health disorders. The review will examine conditions such as depression, anxiety, schizophrenia, bipolar disorder, and other psychiatric or mood disorders across various patient populations, including adolescents, adults, and the elderly.
The review aims to evaluate how digital interventions, including mobile health apps, telepsychiatry, virtual therapy, and digital cognitive behavioral therapy (CBT), enhance patient outcomes, improve adherence to treatment, and support psychiatric nurses in delivering effective care. | null |
CRD420250656437 | What is the impact of nursing interventions on improving access to mental health services among vulnerable populations (Romani people, migrants, and youth) compared to no intervention or standard interventions, according to evidence from clinical trials and cohort studies? | This systematic review focuses on access to mental health services among vulnerable populations, including Romani people, migrants and youth. The study examines how community nursing interventions impact barriers to mental healthcare, such as cultural, geographic, financial and behavioral factors, with the aim of improving accessibility and promoting health equity. The analysis will be guided by the Levesque and PRISM/RE-AIM frameworks. Individuals in vulnerable situations with limited access to mental health services (Romani population, migrants and youth). Community nursing interventions aimed at improving access to mental health services. Inclusion criteria will focus on interventions designed to reduce barriers to mental healthcare and promote access for vulnerable populations. Exclusion criteria will include non-empirical studies and protocols. Absence of intervention or standard interventions that are not specifically aimed at improving access. | null |
CRD42024596858 | How do physical (somatic) and psychological symptoms of postpartum depression differ between individualistic and collectivist cultures, and to what extent do cultural norms influence somatisation in these contexts? | This review focuses on postpartum depression (PPD), a mental health condition that affects women after childbirth, characterised by psychological symptoms (e.g., depression, anxiety) and physical or somatic symptoms (e.g., fatigue, headaches). The review will explore how these symptoms differ across cultural contexts. | null |
CRD42024615711 | What is the association between mentalizing ability and NSSI behaviors? This systematic review aims to systematically review and synthesize relevant studies in this area and present a meta-analysis of this association if appropriate. | Mentalizing ability, Non-suicidal self-injury
Non-suicidal self-injury (NSSI) is a prevalent behavior among adolescents and young adults, particularly those facing emotional challenges. Research indicates that NSSI occurs in approximately 15-20% of adolescents, making it a significant concern in mental health.
Mentalizing ability refers to the capacity to understand and interpret the mental states—such as thoughts, beliefs, desires, and emotions—of oneself and others. This ability allows individuals to make sense of their own behavior and the behavior of others by attributing intentions, motivations, and feelings to actions. It is closely related to concepts like Theory of Mind and reflective functioning and plays a critical role in social interactions, empathy, and emotional regulation.
An individual's mentalizing ability is crucial in understanding and addressing NSSI. Those who engage in NSSI often struggle with managing intense emotions, such as distress, sadness, or anger. They may resort to self-injury as a maladaptive coping mechanism to regulate these overwhelming emotions. Although several studies have demonstrated the effectiveness of Mentalization-Based Treatment in reducing the rate of NSSI, there is a lack of systematic reviews that summarize the characteristics and manifestations of individual mentalizing ability in relation to NSSI. | null |
CRD42024620979 | Our aim is to find out the prevalence of anxiety and depression among frontline medical staff in the early stage of the COVID-19 pandemic and explore the potential influencing factors. | Anxiety, Depression, Mental health of medical staff. | null |
CRD420251035821 | What integrated care service models exist for children and young people (aged 0–18) in primary and community care settings? | Inclusion: Individuals i.e. children in the age range of 0-18 years within a Primary/community care service. Integrated services; Collaborative care; Shared Care; Primary healthcare services; Community Care Inclusion Criteria: 1. A care pathway/service model/ framework is discussed in relation with integrated service for children. 2. Individuals i.e. children in the age range of 0-18 years within Primary and community care settings. 3. The article must report impact on service integration (must report primary data-qualitative or quantitative) 4. Public, voluntary and private health and social care service providers 5. Any community Health care and/or social care service provided by HSCPs (physiotherapists, occupational therapists, speech and language therapists, psychologists, dietitians, social workers etc.) may be in collaboration with medical and nursing professionals. 6. Primary research including service evaluation and pilot studies with available primary data (qualitative, quantitative, or mixed methods). 7. Studies published after 1 January 2016. 8. Stdies published in English language | Exclusion: Individuals above 18 years of age attending non primary/community care services e.g. disability services or acute medical services or residential care services. Exclusion Criteria: 1. Studies not related to integrated care. 2. Individuals above 18 years of age attending non primary/community care services e.g. disability services or acute medical or residential or long term care services. 3. The article does not report impact on service integration 4. Services are provided by medical and nursing professionals exclusively and in settings such as long term care, acute, residential and disability services. 5. Theoretical, conceptual, or commentary papers or papers reporting secondary data such as systematic review or protocols. Standalone projects, initiatives, or one-off interventions that are not embedded in or linked to an integrated service model or pathway such as clinical or condition-specific interventions focused solely on: 6. Studies published before 1 January 2016. 7. Studies published in languages other than English Theoretical, conceptual, or commentary papers or Papers reporting secondary data such as systematic review or protocols. Standalone projects, initiatives, or one-off interventions that are not embedded in or linked to an integrated service model or pathway such as clinical or condition-specific interventions focused solely on: 1. Oncology or palliative care 2. Dental/oral health services 3. Vision/optometry services 4. HIV-specific care 5. Immunisation/vaccination programmes. |
CRD42024575022 | Strictly speaking, PICOS is not applicable to this study.
This article explores the relationship between non-suicidal self-injury (NSSI) and negative life events through meta-analysis. Self-harm is an important issue in the field of adolescent mental health, and negative life events are significant risk factors for self-harm behavior. Many studies have explored the relationship between non-suicidal self-injury and negative life events, but the results of these studies are not consistent.Through literature search and screening, articles that meet the requirements are selected, key data from these articles are extracted, and then imported into meta-analysis software. Through statistical analysis, the correlation between non-suicidal self-injury and negative life events is explored. At the same time, the research team will investigate which moderating variables affect the relationship between the two and which do not. | Non-suicidal self-injury (NSSI) involves an individual deliberately and repeatedly inflicting damage upon their own body tissue without the intent to die. In the context of adolescence, this issue commands particular attention from health professionals and educators worldwide. Extensive research has identified two primary categories of risk factors for NSSI: early childhood trauma and personal vulnerabilities.Research on self-harm primarily revolves around the definition of self-harm behaviors, the factors influencing them, and the construction of theoretical models. To deeply elucidate the reasons and motivations behind self-harm behaviors, researchers have proposed numerous theoretical models, such as the Developmental Case Model and the Integrated Model, each with its own focus. Adolescents are a high-incidence group for self-harm. The rate of self-harm among adolescents has shown an increasing trend over the past decade. Despite the growing body of research on self-harm, there are still many issues that warrant further exploration. | null |
CRD42022339004 | What are children and young people’s experiences of living with IBD? | Inflammatory Bowel Disease | null |
CRD42022298975 | What is the reliability and validity (construct, predictive and incremental) of the SSPI/SSPI-2 in forensic settings? | Psychometric properties. Pedophilia. Pedohebephilia. Screening Scale for Pedophilic Interests. Forensic. | null |
CRD42024574420 | What is the comparative effectiveness of different outreach models in improving substance use outcomes for individuals experiencing homelessness and struggling with addiction? | This review focuses on substance use disorders among homeless populations. | null |
CRD420250616830 | Is Dialectical Behavioural Therapy effective in reducing emotional dysregulation and psychopathology in youth with internalising disorders? | Internalizing behaviour; Anxiety; Depression; Eating Disorder; Suicide; Suicidal Ideation; Self-harm; Emotional regulation ; Posttraumatic Stress Disorder; Somatic symptom and related disorders; Borderline Personality Disorder; Obsessive-compulsive Disorder Youth (6-18years) with internalising disorders/symptomology including those with anxiety, depression, disordered eating, somatic concerns, trauma-related symptoms, borderline personality disorder, obsessive compulsive disorder, suicidal ideation, or self-harm. Inclusion criteria: Youth (6-18 years) including samples with depression, anxiety, somatic concerns, obsessive-compulsive related, trauma-related, eating disorders, and suicidality / self-harm diagnoses or symptomology. Must be stable on pharmacological treatment if applicable. Dialectical Behavior Therapy Inclusion criteria: Dialectical Behavioural Therapy / Skills training with manual or description of intervention included. PICO tags selected: Active control; Placebo; Usual Care Any studies with or without control groups. | Exclusion criteria: • Adult populations above 18 years of age. • Diagnoses or symptoms not related to the mental health conditions described above in inclusion criteria. • Special populations (e.g., intellectual difficulties, autism spectrum disorder, medical conditions). Exclusion criteria: NO other therapeutic modalities (singular or combined with DBT). |
CRD420251030238 | This systematic review aims to elucidate, through the literature, knowledge about the psychological status of patients in the postoperative period of bariatric surgery, taking into account the possible variations that may occur and the repercussions on mental health. | Studies that investigated the association between psychiatric changes and bariatric surgery will be included in this review. Bariatric surgery; Mental Health Screening The database search will be carried out with the selection of the following filters for article types: observational studies. Studies that investigated the association between psychiatric changes and bariatric surgery will be included. | Studies that exclusively evaluated weight loss or other non-psychiatric outcomes were excluded. Studies that exclusively assessed weight loss or other non-psychiatric outcomes were excluded. |
CRD42024613675 | What is the comparative efficacy of transcranial direct current stimulation (tDCS) versus aerobic exercise in treating depression in adults? | Depression, also known as major depressive disorder (MDD), is a common and debilitating mental health condition characterized by persistent feelings of sadness, loss of interest in daily activities, and a range of physical and cognitive symptoms.
Depression can vary in severity, from mild to moderate to severe, and often requires treatment to manage symptoms and improve overall functioning. Traditional treatments for depression include pharmacotherapy (antidepressants) and psychotherapy (e.g., cognitive-behavioral therapy), but a significant number of patients either do not respond to or cannot tolerate these treatments. This has led to increased interest in non-pharmacological interventions, such as transcranial direct current stimulation (tDCS) and aerobic exercise, as alternative or adjunctive treatments.
This review will focus on comparing the efficacy of these two interventions—tDCS and aerobic exercise—in treating depression in adults, assessing their relative effectiveness in reducing depressive symptoms and improving treatment outcomes. | null |
CRD420251020562 | The primary objective of this study is to systematically review the existing literature & perform a meta-Analysis to estimate the prevalence of depression among the medical students in south Asia. Additionally, the study also aims to identify & analyze the numerous pre-existing factors associated with depression in population of this region. | The review will encompass studies from diverse ethnic groups and genders across south Asian region covering those pursuing degrees such as Bachelor of Medicine and Surgery, Bachelor of Dental Surgery, as well as undergraduate medical students, intern doctors, pre-clinical and clinical students, and both residency and non-residency medical graduate trainees. Being medical students. | o Non-medical students. o Studies reporting other than South Asian countries medical students. o Studies on healthcare or university students without any subgroup analysis of medical students. Being medical students. |
CRD420251018358 | Is there an increased prevalence of psychiatric disorders among patients with keratoconus compared to individuals without keratoconus? | Patients diagnosed with keratoconus (any age, any setting). Psychiatric patient care Diagnosis of psychiatric disorders, including but not limited to: depression, anxiety, OCD, schizophrenia, autism, ADHD. PICO tags selected: Healthcare services Patients without keratoconus Observational studies: cross-sectional, case-control, cohort | Case reports or studies without a comparison or prevalence estimate. case series |
CRD420250630757 | Research Question: What is the prevalence of psychiatric disorders in children and adolescents worldwide, and how do prevalence rates vary by age, gender and geographic region?Sub-questions:1. What are the main risk factors associated with psychiatric disorders in children and adolescents?2. How do prevalence rates differ across cultural, socioeconomic and geographic contexts?3. What is the distribution of specific psychiatric disorders (e.g., anxiety, depression, ADHD) in this population?4. How have prevalence rates of psychiatric disorders in children and adolescents evolved over the past decade?The context of the study includes:P-Population: children and adolescents (0-18 years).I-Intervention/Exposure: Not applicable (observational approach).C-Comparison: not applicable (descriptive and analytical focus).O-Outcomes: Prevalence and associated risk factors of psychiatric disorders.Study Design: Cross-sectional, cohort, or patient-mortality studies using standardized diagnostic criteria (e.g., DSM, ICD).The questions aim to provide a comprehensive understanding of the epidemiology of psychiatric disorders in young adults and to formulate targeted public health strategies. | Childhood; Adolescence; Mental disorder; Disease risk factor; Mental Health Review This systematic review focuses on psychiatric disorders affecting children and adolescents. These include conditions such as anxiety disorders, depression, attention-deficit hyperactivity disorder (ADHD), conduct disorders, autistic spectrum, and other psychiatric disorders. The study examines the prevalence, risk factors, and differences by age, gender, and geographic region to improve understanding and management of these conditions. This systematic review focuses on children and adolescents with psychiatric disorders.The review aims to analyze data on the prevalence and risk factors for psychiatric disorders in children and adolescents, taking into account age, gender, and geographic or socioeconomic variations.Eligibility CriteriaInclusion Criteria:1. Studies reporting prevalence or incidence of psychiatric disorders in children and adolescents (0-18 years).2. Studies using standardized diagnostic criteria (e.g., DSM, ICD).3. Studies published in the English language the last decade4. Peer-reviewed articles and high-quality reports. This systematic review does not focus on specific interventions but examines exposure to psychiatric disorders in children and adolescents.Inclusion Criteria:1. Studies that document the prevalence or incidence of psychiatric disorders in children and adolescents (0-18 years).2. Studies using standardised diagnostic criteria (e.g., DSM, ICD).3. Papers published in English in the last decade.4. Studies that are peer-reviewed or high-quality reports. | Exclusion Criteria: 1. Studies focusing exclusively on adults or mixed populations without separate data for children/adolescents. 2. Non-empirical studies, editorials, or gray literature (e.g., theses). Exclusion Criteria: 1. Studies that focus exclusively on adults or mixed populations with no separate data for children/adolescents. 2. Non-empirical studies, editorials, or grey literature (e.g., dissertations). The report is reviewed through observation and analysis of risk factors, epidemiological trends and diagnostic patterns, providing a comprehensive picture of the epidemiology of psychiatric disorders in young adults. |
CRD42024579204 | What are the differences in mental health outcomes between art production and appreciation? | Mental health and wellbeing outcomes (anxiety, depression, stress, wellbeing). | null |
CRD420250654988 | Aim 1: To identify the evidence-based treatments or adaptations of evidence-based treatments that have been utilized to treat Muslims with clinical and subclinical psychiatric disorders.Aim 1a: Determine what types of treatments have been delivered to Muslim populations.Aim 1b: Identify which specific disorders have the treatments attempted to target. Aim 2: To determine the benefits of treatments addressing clinical and subclinical psychiatric disorders in Muslims. Aim 2a: Evaluate how the treatments were adapted, if they were. Aim 2b: Determine the efficacy/effectiveness and feasibly of the treatments. Aim 3: To identify gaps in the treatment and offer recommendations to clinical providers, researchers, and Muslim community leaders who seek to target Muslim clinical and subclinical psychiatric disorders. | Evaluate the state of the literature on evidence-based treatments for mental health problems among Muslims. Study must include participants who identify as Muslim, regardless of national and ethnic background. Study must include symptoms or diagnosis of at least one mental health and/or substance use problem. A formal mental health diagnosis is not required. Must be a clinic trail that has at least an experimental condition and control/usual care condition. | Do not identify as Muslim A mental health and/or substance use symptom or diagnosis was not assessed. |
CRD42023457357 | research question is:
What is the efficacy of art therapy interventions in reducing depressive symptoms among children and adolescents with diagnosed depression?
To address this main question, we will further refine our inquiry through the following specific sub-questions:
Population (P): What are the characteristics of children and adolescents with diagnosed depression who have participated in art therapy interventions?
Intervention (I): What types of art therapy interventions have been utilized for treating depression in this population?
Comparison (C): To what extent have control or comparison conditions been implemented in studies assessing art therapy for depression in children and adolescents?
Outcomes (O): How are the depressive symptoms of participants measured following art therapy interventions?
Study Designs: What types of study designs have been employed in evaluating the effectiveness of art therapy for depression in children and adolescents? | In our systematic review titled "A Systematic Review and Meta-Analysis of Art Therapy for Depression in Children and Adolescents," we are focusing on the treatment of depression in the pediatric and adolescent population. Depression is a common mental health disorder characterized by persistent symptoms such as sadness, loss of interest, decreased energy, and low self-esteem. This condition can significantly impact the daily lives, academic performance, and social interactions of children and adolescents. Therefore, finding effective interventions is crucial for improving their mental well-being.
This study aims to assess the efficacy of art therapy in treating depression among children and adolescents through systematic review and meta-analysis. We will gather and synthesize existing research to determine whether art therapy holds potential benefits in alleviating depressive symptoms, enhancing psychological well-being, and improving overall quality of life. By delving into this field, we intend to provide more therapeutic options and recommendations for enhancing the mental health of children and adolescents. | null |
CRD420250652619 | What are the lived experiences of British Army Officers Wiveswhat are the demands and responsibilities placed on Army Officers Wives and the effect on their psychological wellbeingPsychological wellbeing Army Officers wives | Psychological distress; Psychological well-being; Mental Distress Psychological wellbeing of British Army Officers Wives Women married to Army Officers and the effect on their psychological wellbeingInclusion criteria: Women married to current officers in the British Army Psychological Analysis; Emotional Support; Stress Management; Coping Support What are the lived experiences of British Army Officers Wives: what are the demands and responsibilities placed on them and the effect on their psychological wellbeing.Specifically, the objectives of the review were to gather and synthesize the existingknowledge relating to:- The day-to-day experiences of AOWs during the time their husband has been an Army Officer, the challenges they faced, how they managed and coped with these and the impact on their psychological wellbeing. PICO tags selected: Psychological Well-being Education; Stress Management; Coping Support | Women married to current serving soldiers who husbands were not Army officers Women married to officers who were serving in the Navy, Marines or Royal Airforce Women married to Army officers, whose husband has now left service |
CRD42024554280 | 1. To estimate the pooled association between stress and various indicators of emotional well-being in medical and allied students.
2. To assess the between-study heterogeneity and its possible sources of variations. | This research investigates the various impacts of stress, including its emotional well-being effects. By synthesizing and quantitatively analyzing the consequences of stress, the study seeks to address inconsistencies in previous research. This research targets the students of medical allied subjects from all backgrounds, races, religions, and regions. Anticipatory implications include informing policymakers on effective regulations, guiding the creation of stress management programs, aiding in the development of advanced detection tools, and leading to targeted psychosocial interventions to mitigate negative effects on mental health and social behavior. | null |
CRD42024532820 | Broad research question: What are clinician’s attitudes towards online therapy?
Specific questions include:
• How do clinicians perceive online therapy overall?
• What are the perceived benefits of online therapy?
• What are the perceived disadvantages or barriers to online therapy?
• How do clinicians understand the differences between online and face-to-face treatment?
• How has the pandemic impacted clinicians’ attitudes to online therapy?
• What were clinicians’ experiences of the transition to online therapy? | Mental health clinicians' attitudes towards online therapy. | null |
CRD420251021161 | How do probiotics and prebiotics affect gut microbiota composition in humans? | Healthy adults or adults with depressive disorders, anxiety disorders, sleep disorders, or pain. Probiotics; Prebiotics ecas | Inclusion criteria: Age: Adults (≥18 years). Health status: Healthy individuals or those diagnosed with depressive disorders, anxiety disorders, sleep disorders, or chronic pain. Intervention: Studies evaluating the effects of probiotics and/or prebiotics on gut microbiota and their relationship with mental health. Study design: Clinical trials, cohort studies, and case-control studies. Publication: Articles published in peer-reviewed scientific journals within the last 10 years. Exclusion Criteria: Age: Individuals under 18 years old. Severe comorbidities: Patients with neurodegenerative diseases, cancer, severe inflammatory bowel diseases (such as Crohn's disease or ulcerative colitis), or immunosuppression. Mixed interventions: Studies where the effects of probiotics and prebiotics cannot be distinguished from other interventions (e.g., general dietary changes or psychotropic drugs). Animal or in vitro studies. Systematic reviews or meta-analyses (except for reference search purposes). Studies with low methodological quality or without a control group. pilots, protocols and revision |
CRD420251030337 | The primary objective of this review is to investigate the association between online gambling and substance dependence in children and adolescents. Specifically, the review will address the following questions: | Age group: Individuals aged 18 years or younger (children and adolescents) Condition: Participants involved in online gambling activities, with or without a diagnosed substance use disorder. Geographic criteria: Studies conducted globally, including both developed and developing countries. Language: Studies published in English and Greek. Study type: Empirical studies, including observational, cohort, and cross-sectional studies, as well as intervention studies focusing on online gambling and substance dependence. Drug Addiction Counseling; Screening For Mental Disorders; Cognitive Behavioral Therapy; Psychosocial Care; Parenting Education; Organizational policies and procedures Published studies in English or Greek Primary studies (quantitative, qualitative, or mixed-method) Studies examining the relationship between online gambling and substance use/addiction Publication period from 2010 to 2025 Studies including participants up to 18 years old Studies using appropriate research methodologies (e.g., longitudinal, cross-sectional studies, meta-analyses) This review does not include specific comparators or control groups as it focuses on exploring the relationship between online gambling and substance use in adolescents. The studies included will not compare interventions or treatments but rather aim to assess the correlation between online gambling behavior and substance use disorders among minors. Therefore, no specific comparator criteria are applicable for this review. Observational studies (cohort studies, case-control studies, cross-sectional studies) Non-randomised studies Quantitative studies (including statistical analyses) Qualitative studies (if relevant) Mixed-methods studies (if applicable) Systematic reviews or meta-analyses (if relevant studies are available) | Age group: Individuals older than 18 years (adults). Condition: Participants who do not engage in online gambling activities or who do not have a diagnosis of substance use disorder. Language: Studies published in languages other than English or Greek. Study type: Studies that do not focus on the relationship between online gambling and substance use disorder, such as studies on gambling behavior unrelated to addiction. Geographic criteria: Studies from regions with no relevant data on youth online gambling or substance use disorder, or from countries where gambling is illegal for minors. Studies focusing exclusively on adults Studies that do not provide clear evidence regarding online gambling or substance use Opinion pieces, commentaries, or non-empirical research Studies published more than 10–15 years ago Studies published in languages other than Greek or English Since this review does not include specific comparator groups or interventions, no exclusion criteria for comparators are applicable. The focus of this review is solely on examining the relationship between online gambling and substance use among adolescents, without comparison to other interventions or control groups. Studies focusing solely on adult populations (18 years and older) Studies that do not provide clear information on online gambling or substance use Opinion papers, commentaries, or non-empirical research Studies older than 10-15 years Studies in languages other than English or Greek Studies not involving a direct relationship between online gambling and substance use |
CRD42024502091 | Aim: To systematically review the literature to assess the effectiveness of (digital) resource-oriented interventions (both organisational and individual-level) designed to improve work engagement and well-being.
A) How do (digital) resource-oriented organizational-level and individual-level interventions impact work engagement and well-being of employees?
B) What differences exist between organisational-level and individual-level interventions regarding their effectivness on work engagement and well-being?
C) What works for whom under which circumstances? How do the following variables influence the effectivness of interventions on work engagement and well-being
- company size (SMEs vs. large enterprises)
- intervention type (digital vs. non-digital) | In our systematic review, we focus on mental health in the workplace, a critical area of research given the profound impact work has on employees' psychological well-being. Specifically, we will examine perceived work engagement as a indicator of well-being. This involves exploring how resource-oriented interventions (e.g. aimed at enhancing perceived job autonomy, social support, and feedback) influence employees' work engagement and how this, in turn, affects their mental health and overall well-being. | null |
CRD420251001065 | null | Cognitive Behavioral Therapy; Behavioral Therapy; Group Cognitive Behavioural Therapy; Internet-delivered Cognitive Behavioural Therapy; Mindfulness-based Cognitive Therapy; Sleep And Rest Interventions; Motivational Interviewing Technique; Mindfulness; Bright white light therapy; Psychotherapy; Psychosocial Intervention Strategy; Psychosocial intervention; Light Therapy PICO tags selected: Usual Care; Attention Placebo Control; Medication prescription; Pharmacotherapy Studies with any comparator and/or no comparator will be included. 1. Randomized controlled trials (including cluster randomized controlled trials) 2. Pilot studies 3. Single-arm treatment studies with no control condition 4. Non-randomized clinical trials | null |
CRD42022340129 | Primary: To compare the complication rates of different fusion techniques for the surgical treatment of lumbar degenerative spondylolisthesis using two classification schemes (general classification that includes intraoperative and post-operative complications, and modified Clavien-Dindo classification), including ALIF, OLIF, LLIF, XLIF, TLIF-Open, TLIF-MIS, PSDF, and PLIF. | Primary: What is the most effective fusion surgery for improving disability and pain in adults with degenerative
spondylolisthesis.
Secondary: What is the most effective treatment for improving and mental health in adults with degenerative
spondylolisthesis.Complication reporting follows different formats, during or following different fusion surgeries for lumbar degenerative spondylolisthesis. Further, there is a lack of information as to which disc removal technique has the lowest complication rate. We performed a network meta-analysis (NMA) to compare the complication rates of different fusion techniques for the surgical treatment of lumbar degenerative spondylolisthesis using two classification schemes (general classification that includes intraoperative and post-operative complications, and modified Clavien-Dindo classification), including ALIF, OLIF, LLIF, XLIF, TLIF-Open, TLIF-MIS, PSDF, and PLIF. | null |
CRD420250610648 | This systematic review and meta-analysis aim to evaluate the effects of cannabidiol (CBD) use for the treatment of neuropathic pain or neuropathies during pregnancy on neonatal outcomes. Neuropathic conditions may require pharmacological management, but the safety of CBD use in this context remains unclear, especially regarding fetal and neonatal risks. As the therapeutic use of cannabinoids grows, particularly in populations seeking alternatives to traditional medications, understanding potential neonatal effects is crucial. | Cannabinoids; Pregnancy ; Neonatal Death The condition being studied in this systematic review is the use of cannabidiol (CBD) for managing neuropathy in pregnant women and its potential impact on neonatal outcomes. Neuropathy, a condition resulting from nerve damage, can cause severe pain, sensory disturbances, and functional impairments. During pregnancy, neuropathy may arise due to various factors, including gestational diabetes, autoimmune conditions, or pre-existing neuropathic disorders. Managing neuropathic pain in pregnant women is challenging due to the limited options for safe analgesic treatments that avoid potential harm to the developing fetus.Cannabidiol (CBD), a non-psychoactive component of cannabis, has gained attention as an alternative for pain management, given its reported anti-inflammatory and neuroprotective properties. Unlike tetrahydrocannabinol (THC), CBD does not have psychoactive effects, making it a potentially safer option for managing neuropathic pain during pregnancy. However, there is limited evidence on the safety and effects of CBD use in pregnant women, especially regarding neonatal outcomes, such as neurological development, birth weight, and perinatal complications. This review aims to assess the existing evidence on these outcomes, addressing an important gap in maternal-fetal health research. Inclusion criteria encompass studies involving pregnant women with neuropathic conditions who used CBD, either alone or with other treatments, and report neonatal outcomes such as birth weight, gestational age, neurological development, or perinatal complications. Cannabinoids; Drug Therapy; Traditional, complementary and alternative medicine Specifically for managing neuropathic pain. CBD, a non-psychoactive compound from the cannabis plant, is known for its potential analgesic, anti-inflammatory, and neuroprotective properties, making it a candidate for alternative pain management in pregnancy. Given the limited options for safe neuropathy treatments during pregnancy, CBD’s effectiveness and safety are critical areas of interest.Inclusion Criteria for the intervention include studies where pregnant women used CBD alone or in combination with other treatments specifically to manage neuropathic pain. Eligible studies may involve various CBD administration methods, including oral ingestion, topical application, and other clinically relevant forms, provided the dosage and frequency are documented. The review will include studies reporting CBD's impact on neonatal outcomes, such as neurological development, birth weight, and perinatal complications. PICO tags selected: Usual Care; Physical therapy exercises; Antidepressants In this review, the primary comparator is pregnant women with neuropathic pain who did not use cannabidiol (CBD) or who used alternative treatments. Comparators include other pain management approaches commonly prescribed for neuropathic pain, such as acetaminophen, antidepressants (e.g., amitriptyline), or physical therapy. Additionally, studies with a non-exposed control group, including women with neuropathy who opted for no pain intervention during pregnancy, are included to examine differences in neonatal outcomes associated with CBD use.Inclusion Criteria for the comparator/control group include studies involving pregnant women with neuropathies similar to those in the intervention group but who used non-CBD treatments or no treatment at all. These groups will help isolate the effects of CBD on neonatal outcomes compared to standard care practices or absence of intervention. | Exclusion criteria include studies where participants used cannabis products containing THC or those unrelated to neuropathy. Studies without neonatal outcomes or focused only on maternal health, as well as non-human studies, will also be excluded. Exclusion Criteria involve studies where CBD was used for conditions unrelated to neuropathy, such as nausea or anxiety, or where other cannabis compounds (notably THC) were present, given THC's different psychoactive properties and potential fetal impact. Studies without detailed neonatal outcomes or lacking clear descriptions of CBD dosage and administration will also be excluded to ensure focused and relevant data on the intervention's safety and efficacy in this population. Exclusion Criteria include studies where comparators involve exposure to cannabis products containing THC, as its psychoactive properties may confound neonatal outcomes. Studies with control groups that differ substantially in underlying neuropathic conditions or pain management approaches not relevant to pregnancy will also be excluded to maintain comparability. Additionally, studies lacking clear descriptions of the comparator treatments or control conditions will be excluded to ensure valid comparisons with the CBD intervention group. |
CRD42023380735 | 1. What are the tools that have been validated for alcohol screening for problem drinking in older persons(over 65’s)
2. What is the accuracy for each of these alcohol screening tools for identifying problem drinking in older persons (over 65's) | Screening tools for problem drinking in older adults (over 65's). | null |
CRD42024526211 | (1) What factors are related to the development of burnout in student-athletes?
(2) How does burnout affect student-athletes?
(3) Is student burnout related to athlete burnout?
(4) Can this information be used to develop a transcontextual model of student-athlete burnout? | Burnout (student burnout and athlete burnout) | null |
CRD420250656267 | What is the effect of Transcranial Alternating Current Stimulation (tACS) in reducing hallucinations in patients with psychiatric disorders compared to other Non-invasive Brain Stimulations?
P - Patients with any psychiatric disorder experiencing hallucinations.
I - tACS
C - Other treatment as usual or any other modalities of Non-Invasive Brain Stimulation
O - Reduction in Hallucination | The psychotic symptom of ‘Hallucinations’ across various psychiatric disorder. | null |
CRD420251029828 | Review question: In patients hospitalized in intensive care units, what is the effectiveness of music in reducing neuropsychiatric symptoms compared to any other type of intervention? | Studies including patients over 18 years of age hospitalized in the ICU who are conscious or able to respond to questions. Music Therapy PICO tags selected: Usual Care; Placebo; Non-Pharmacological Interventions; Pharmacotherapy | Studies including patients over 18 years of age with pre-existing mental health disorders prior to ICU admission, older adults with cognitive impairment, or neurocritical patients experiencing an acute episode. |
CRD42025565969 | The relationship between loneliness and psychosis is highly complex. Though plenty of studies have substantiated a correlation between loneliness and psychosis, a thorough understanding of the interaction between mutually occurring and underlying variables has proven difficult to explicate. Previous systematic reviews in the area have highlighted challenges in terms of methodological heterogeneity in the literature, as well as the disparate foci of research examining the complex phenomenology of loneliness in people with psychosis. This review aims to provide an overarching framework to capture the breadth of studies examining the complex relationship between loneliness and psychosis. This review will take a meta-narrative approach in order to provide a comprehensive overview of research in the field, with the aim of synthesising the breadth of data available to develop a framework which captures the potential interplay between different variables, highlighting areas that require further study. | Psychosis and the experience of loneliness in people with psychosis | null |
CRD420250614684 | - What are the mental health experiences of transgender/ gender diverse autistic individuals? - What are the risk factors that increase mental health difficulties for transgender/ gender diverse autistic individuals? - What are the protective factors which decrease mental health difficulties for transgender/ gender diverse autistic communities? | Mental Health History The review is being completed as a part of the DClinPsy trainee project. The review will look to explore the mental health experiences of transgender individuals who are autistic (self-diagnosed or formally diagnosed). The empirical paper will look at the experiences of transgender/ gender diverse adults regarding their social communication and related emotional wellbeing. Research suggests that experiencing difficulties or differences with social communication can impact mental health and wellbeing. Therefore, a systematic review looking at the mental health experiences for transgender/ gender diverse autistic will helpfully shed light on the general mental health experiences of these communities, as well as providing insight into what the factors decrease and increase mental health problems for these communities. For this project, mental health will also be searched in conjunction with wellbeing, mental health disorders, social support. For this study we will be looking at risk factors that increase mental health difficulties for transgender/ gender diverse autistic individuals. We will also look at the protective factors which decrease mental health difficulties for transgender/ gender diverse autistic individuals. Further, in knowing the risk and protective factors, we are in better steed for recommending and exploring what more services can be doing to support these communities. -Participants identify as transgender or gender diverse - Participants identify as or are diagnosed as autistic - Children, teens, young adults, adults, older adults - Qualitative in methodology, or if mixed methods, reports qualitative results independent of quant results - Peer reviewed publications (The trainee can include current conference papers and unpublished papers as "ongoing research" for future reviews.) - Papers will be identified in all languages, only ones in English will be used Mental health experiences (see above) and factors which increase and decrease mental health difficulties for transgender autistic individuals. This could include, but is not limited to, emotional regulation, self-harm, behavioural difficulties etc. | - Papers which report only quantitative data. |
CRD420250645699 | In adult patients diagnosed with schizophrenia-spectrum disorders, does the use of statins as adjunctive therapy, compared to conventional treatment, improve clinical symptoms? | Schizophrenia spectrum disorders are a group of mental health conditions characterized by disturbances in thought, perception, emotions and behavior, which includes schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, and brief psychotic disorder. The symptoms are hallucinations, delusions, disorganized thinking, and impaired social functioning and the treatment typically involves antipsychotic medications and psychosocial support. Adults diagnosed either with schizophrenia, schizoaffective, schizophreniform disorder or psychotic disorder not otherwise specified. The use of statins (simvastatin or atorvastatin or rosuvastatin or pravastatin or lovastatin) plus an antipsychotic (clozapine or risperidone or olanzapine or quetiapine or aripripazole or ziprasidone or paliperidone or lurasidone or haloperidol or chlorpromazine). The intervention is compared to a control group in use of antipsychotics plus placebo or with treatment as usual (standard care typically provided in the treatment of individuals with schizophrenia-spectrum disorders). | null |
CRD42025642260 | 1) What are the short and long term mental health impacts of dating violence on youth ?
2) How do sociocultural elements such as patriarchal norms family honor and societal expectations, contribute to the prevalence and manifestation of dating violence.
3) What gaps exist in the current literature on dating violence in India , and how can future research address these gaps to provide a more comprehensive understanding of the issue. | There are a number of definitions of Dating violence given from time to time by different researchers . Perhaps the most influential definition is provided by Sugarman & Hotaling (1989) defining dating violence as all words, gestures, or actions that involve threatening or using painful or harmful physical or psychological force against one's partner while in a relationship.Although definitions of dating violence abound, most scholars and organizations agree on a few core concepts. First, Physical force - Involves Beating, slapping, thrashing, scratches and the use of weapons tools. Second, Psychological/emotional force- It gives rise to actions like contempt, reprimanding, intimidation, embarrassment and social restrictions. Third, Sexual force - It is characterised as when one partner coerces the other into having sex or performing other sexual actions against the consent of their partner. However, in words of Joseph and Kuperminc (2020) dating violence includes intentional, persistent, and control-focused acts of hostility. Nowadays, dating violence is recognized as a serious public health issue that impairs the physical and mental well-being of those exposed to it. | null |
CRD420250645717 | What is the effectiveness of telehealth-based psychological support interventions in improving mental health outcomes (such as anxiety, depression, and quality of life) for pediatric oncology patients and their families? | Cancer Pain; Problematic Behavior In Children; Telehealth; Anxiety; Depression Pediatric oncology patients (0-18 years) and their families. Telehealth-based psychological support (e.g., family counseling, psychoeducation). Anxiety, depression, quality of life, caregiver burden, family functioning, patient/family satisfaction. Pediatric oncology patients (0-18 years) and their families. Telehealth; Family Support; Psychological Counseling Telehealth-based psychological support (e.g., family counseling, psychoeducation). PICO tags selected: Supportive care; Waiting list control Studies with comparison groups (e.g., in-person support, waitlist control, or no intervention). | Non-pediatric oncology populations In-person interventions or non-psychological interventions |
CRD420251018266 | This review will identify the available community-based psychosocial interventions that support parents after a pregnancy loss or the death of a baby (up to 30 days old). To do so, this review will answer the following research questions: | Parents bereaved by a perinatal loss including miscarriage, termination of pregnancy due to fetal anomaly (TOPFA), stillbirth, and neonatal death (up to 1 month of life). As gestational age varies globally, there will be no restrictions on gestational age used in definitions. This review takes into account a broad definition of perinatal loss because definitions of perinatal loss vary globally, with the WHO defining it as stillbirths from 28 weeks and early neonatal deaths within the first seven days of life, while other systems, such as the ICD-11 and national guidelines, use gestational cut-offs ranging from 20 to 24 weeks (WHO,2006; Comfort et al., 2024) Psychosocial intervention 1.Psychological or social interventions related to grief management for perinatal loss. 2.Interventions implemented in the community (not limited to but including: Primary health care centers, home, school, churches, virtual, peer support) | Non-human participant study Abortions not related to foetal anomaly 1. Studies implemented in secondary and tertiary hospitals, specialist medical and research facilities 2. Interventions that are not psychological or social 3. Interventions that are not targetting psychological outcomes (including but not limited to anxiety, depression, grief, stress) and social outcomes (including but not limited to stigma, isolation, relationship difficulties) following perinatal loss. |
CRD42019134461 | Do facilitated arts psychotherapies improve the mental health of young people with long-term physical health conditions? | Mental health and well-being in long-term paediatric physical health conditions, including, for example: rheumatological diseases, inflammatory and autoimmune conditions or cancer. Inclusion: children and adolescents (aged 18 years or under), with long-term physical health conditions, in inpatient or outpatient settings.Exclusion: children with mental health conditions (without physical health conditions), intellectual disability or neurodevelopmental conditions. Arts psychotherapies: defined as those aiming to improve health through creative expression (including e.g. drawing, model making, dance, photography, drama or music) and the establishment of a therapeutic relationship promoting communication and self-awareness. Interventions may be delivered one-to-one or in a group and as a single or series of sessions.Studies in which the primary aim is not to promote health (for example, those looking at passive arts interventions for distraction, with no involvement of a therapist, no establishment of a therapeutic relationship or interactive communication (e.g. just listening to music or painting/ drawing for pleasure, or for relaxation or to become more skilled)) will be excluded. PICO tags selected: Usual Care | null |
CRD420250656549 | "In patients with diabetes, how do diabetic foot ulcers affect quality of life as measured by the SF-36 compared to diabetic patients without foot ulcers and healthy patients? | Diabetic Foot Ulcer Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, primarily resulting from neuropathy and poor peripheral circulation. These ulcers significantly increase the risk of infections, leading to prolonged hospital stays and even lower limb amputations. DFUs not only affect physical health through pain, limited mobility, and risk of amputation but also influence mental and emotional well-being. Assessing Qulaity of Life (QoL) can reveal how these ulcers disrupt daily activities, social interactions, and overall life satisfaction. Adults (over 18 years old) diagnosed by a physician with diabetes type I or II and foot ulcers. NA The review compares the quality of life of patients recently diagnosed with DFU to patients living with DFU since a longer period of time. | null |
CRD420250610639 | Does Vitamin E supplementation reduce biomarkers of oxidative stress (such as malondialdehyde [MDA], glutathione [GSH], superoxide dismutase [SOD], and catalase [CAT]) in patients with schizophrenia compared to placebo or standard care? | Schizophrenia; Vitamin E; Placebo Adults diagnosed with schizophrenia or other chronic mental illnesses (such as schizoaffective disorder or bipolar disorder), according to any recognized diagnostic criteria. Individuals who have developed antipsychotic-induced tardive dyskinesia (TD), with TD defined as persistent, involuntary movements (typically of the face, mouth, trunk, or limbs) that arise during or after long-term neuroleptic (antipsychotic) treatment. Participants must be currently receiving antipsychotic medication or have developed TD following antipsychotic exposure. No restrictions on gender, ethnicity, or nationality Vitamin E The intervention of interest is Vitamin E supplementation, administered alone or in combination with other antioxidants (e.g., Vitamin C) or nutrients, as an adjunct to standard antipsychotic treatment in patients with schizophrenia or related chronic mental illnesses. Dosage and duration of Vitamin E supplementation may vary across studies but typically range from moderate to high doses (e.g., 300 IU to 600 IU daily) and treatment durations from several weeks to months. Studies must include participants who are currently receiving antipsychotic medication and have developed or are at risk of developing antipsychotic-induced tardive dyskinesia (TD) or other movement disorders related to oxidative stress. Both randomized controlled trials and controlled clinical trials comparing Vitamin E supplementation to placebo, no intervention, or other treatments are eligible. Studies examining the effect of Vitamin E on biomarkers of oxidative stress (such as malondialdehyde, glutathione, superoxide dismutase) as well as clinical outcomes related to TD are included. PICO tags selected: Placebo The comparator(s) inclusion criteria for the review are as follows: Studies must include a placebo control group or a no-intervention group against which Vitamin E supplementation is compared. This allows assessment of Vitamin E's efficacy relative to no active treatment. Comparators may also include standard care or usual treatment without Vitamin E, provided the control group does not receive any antioxidant supplementation that could confound results. Studies comparing Vitamin E to other active treatments (e.g., other antioxidants, pharmacologic agents for tardive dyskinesia) may be included if the effects of Vitamin E can be isolated or if such comparisons are analyzed separately. Trials without a comparator or control group (e.g., uncontrolled case series) will be excluded to ensure the reliability of effect estimates. The comparator groups should be matched in terms of baseline characteristics and antipsychotic treatment to minimize bias. | Individuals without a diagnosis of schizophrenia or another chronic mental illness. Patients who have not developed antipsychotic-induced TD (i.e., those without clinical evidence of TD as defined by standardized criteria such as the Abnormal Involuntary Movement Scale). Studies involving only animal or in vitro models. Patients with movement disorders not attributable to antipsychotic medication (e.g., Parkinson's disease, Huntington's disease). Case reports, case series with fewer than three participants, and studies without a control or comparator group Studies where Vitamin E is combined with other supplements (e.g., omega-3 fatty acids, Vitamin C) without separate analysis of Vitamin E's effects may be excluded, unless the effect of Vitamin E alone can be clearly distinguished. Studies administering Vitamin E at doses or in contexts shown to potentially worsen psychotic symptoms, particularly in acute episodes or in patients with low polyunsaturated fatty acid (PUFA) levels, may be excluded or analyzed separately due to possible adverse effects. Interventions that do not clearly specify Vitamin E supplementation as a distinct treatment component or do not report outcomes related to tardive dyskinesia, extrapyramidal symptoms, or oxidative stress biomarkers should be excluded. Studies focusing solely on Vitamin E for conditions unrelated to antipsychotic-induced movement disorders or schizophrenia will be excluded. Non-controlled studies, such as case reports or uncontrolled case series, where the effect of Vitamin E cannot be reliably assessed, will be excluded. Studies involving populations other than adults with schizophrenia or related chronic mental illnesses (e.g., children, healthy volunteers) will be excluded. Studies where Vitamin E is used in acute psychotic episodes without stable antipsychotic treatment may be excluded due to evidence suggesting possible worsening of symptoms in this context. Studies without a control or comparator group, such as uncontrolled case series or case reports, will be excluded to ensure reliable assessment of Vitamin E's effect. Comparators that include other antioxidant supplements combined with Vitamin E, where the effect of Vitamin E alone cannot be isolated, will be excluded unless separate analysis is possible. Studies comparing Vitamin E to active treatments known to have confounding antioxidant or psychotropic effects without clear distinction of Vitamin E's specific impact may be excluded. Comparators involving acute psychotic episode treatments without stable antipsychotic therapy may be excluded due to potential confounding effects on outcomes. Studies where the comparator group receives no standard care or inappropriate controls that do not reflect usual clinical practice may be excluded to maintain relevance and validity. |
CRD42024550032 | 1. What is the prevalence of mental health disorders among school-aged children living in Regional, Rural and Remote (RRR) Australia?
2. Are there differences in rates of mental health disorders according to geographical location in Australia, particularly between children living in metropolitan Australia compared to those living in RRR Australia?
3. Are there any differences in rates of child mental health disorders by gender and age group within RRR areas? | Mental health disorders in children and adolescents | null |
CRD420250653288 | What is the effect of probiotic administration on rodent models of Multiple Sclerosis? | Multiple sclerosis (MS) Our review will consider mice or rat models with multiple sclerosis. In this systematic review, we will examine the effect of probiotic administration in rodent models of multiple sclerosis. Different strains, doses, and duration will be considered in this review. Control intervention groups will include standard care and placebo groups, with PBS or saline serving as the control; if these groups are absent from the study, the untreated group will be considered as the control. | 1. Animal models other than those for multiple sclerosis.
2. Animal species other than mice or rats.
3. Studies that are exclusively in vitro, ex vivo, in silico, or conducted on humans. Exclusion criteria: All interventions except for probiotics are excluded. Any groups not specified in the inclusion criteria |
CRD42022363592 | The goal of this systematic review and meta-analysis is to synthesize empirical research on the link between minority stress exposure and emotion regulation processes, including strategies and abilities. We hope to address the following questions:
1. What emotion regulation strategies and abilities have been examined by the current sexual and gender minority (SGM) minority stress literature?
2. What is the magnitude of the association between minority stress exposure and use of emotion regulation strategies (e.g., mindfulness) among SGM individuals?
3. What is the magnitude of the association between minority stress exposure and emotion regulation abilities (e.g., emotional clarity) among SGM individuals?
a. If sufficient literature exists, what is the relationship between emotion regulation flexibility and minority stress?
4. Is the link between minority stress and emotion regulation moderated by type of minority stress (e.g., proximal vs. distal)?
5. Is the link between minority stress and emotion regulation moderated by key factors, which will include:
a. Mean Age
b. Sexual Orientation Sub-group (e.g., gay/lesbian, bi+, questioning)
c. Gender Identity Sub-group (e.g., binary trans, non-binary, cisgender)
d. Racial / Ethnic Minority Subgroup (e.g., Black or African American, Asian and Pacific Islander, white)
e. Year of publication
f. Other types of minority stress as identified during the literature review process | This review focuses on minority stress, i.e., forms of stress that relate directly to one’s sexual and/or gender minority status. Minority stress can be conceptualized as distal (e.g., structural inequities) and proximal (e.g., internalized stigma). Emotion regulation processes refer to both strategies and abilities pertaining to one’s ability to maintain, identify, and control emotional states. Emotion regulation processes are thought to be fruitful treatment targets to address the vast mental health disparities faced by SGM individuals. | null |
CRD420250614649 | Question: How and why are Single Case Experimental Designs (SCEDs), utilizing Ecological Momentary Assessment (EMA), used persons with a psychiatric diagnosis and what are the outcomes of these studies? | Persons with a DSM-V psychiatric diagnosis (transdiagnostic) Inclusion: Persons diagnosed with a psychiatric diagnosis as included within the DSM-V. Clinically assessed and/or with a diagnostic instrument/ questionnaire. Ecological Momentary Assessment (EMA) or comparable (including: "Ecological Momentary Assessment", "ecological momentary assessment*", "ESM", "experience sampling*", "ecological momentary intervention*", "EMA", "event-contingent recording*", "self-monitoring*", "internet-based monitoring", "ambulatory assessment", "intensive repeated measure*", "dynamic assessment*", "smartphone-based monitoring*", "daily assessment*", "Interrupted Time Serie*, "interrupted time serie*", "daily diar*", "diary record*", "passive sensing", "active sensing*", "sensor data", "electronic diar*") that is used to identify or record changes that might be attributable to psychiatric treatment or other situations. | Persons without a psychiatric diagnosis Interventions without incorporation of a clinician who (a) assessed and/or manages, (b) prevents, (c) monitors, or (d) measures study participants and interventions that do not take place in a mental health care setting, will be excluded. |
CRD42023410525 | How has the COVID-19 pandemic impacted the mental wellbeing and related physical health of Indigenous youth throughout Canada and USA based on geographic location, age, protective and risk factors?
The objectives are to (1) explore the different mental wellbeing and related physical health impacts; (2) identify moderators, such as location and age as they relate to mental wellbeing impacts and; (3) discuss protective and risk factors. | Mental health and wellbeing (e.g., depression, anxiety, loneliness, fear, mental illnesses/disorders, phobias, isolation, withdrawal, sadness, mood, emotions, stress, trauma, wellness, behavior problems, PTSD, OCD, suicidality, quality of life) and/or physical health and wellness and/or resiliency/protective factors/risk factors. Physical health and wellness will be focused on physical symptoms often comorbid with mental health (e.g., sleep, insomnia, weight gain/loss, self-harm, non-suicidal self-injury, suicide attempts, disordered eating, low energy, headaches, chronic pain, body pain/aches, functional abdominal pain). | null |
CRD420250627222 | Objectives or Questions of the Review: | Temperamental; Epigenome level; Temperament Testing This systematic review focuses on the emerging field of morphogenetic temperaments, which integrates psychoneuroimmunoendocrinology (PNIE) and epigenetics to propose a novel typology of human temperament. The study explores how psychological, neurological, immunological, and endocrine systems interact to shape individual differences in temperament. The review examines the biological underpinnings of temperament, including genetic factors, epigenetic mechanisms, and the interplay between environmental influences and physiological responses. It investigates how these complex interactions contribute to the development and expression of temperamental traits. By incorporating recent advances in PNIE and epigenetics, this study aims to provide a more comprehensive understanding of temperament than traditional models. It explores how early life experiences, stress responses, and environmental factors can influence gene expression and neural pathways, ultimately shaping an individual's temperamental profile. The review also considers the potential clinical implications of this integrated approach, including its relevance to personalized medicine, mental health interventions, and the prevention and treatment of stress-related disorders. "The population included in this systematic review will consist of human participants of any age and gender. Studies must focus on individuals assessed for temperamental traits or typologies, particularly those related to morphogenetic temperaments. Participants must be evaluated within the context of psychoneuroimmunoendocrine systems and/or epigenetic mechanisms. No restrictions will be applied regarding ethnicity, socioeconomic status, or geographic location." Environmental Intervention; Psychosocial intervention; Investigations This systematic review will include studies that examine: Epigenetic mechanisms related to temperament, such as DNA methylation, histone modifications, and non-coding RNAs. Gene-environment interactions influencing temperamental traits. Psychoneuroimmunological interventions or assessments that explore the relationship between temperament and immune function. Methods for evaluating and classifying morphogenetic temperaments. Neurodevelopmental interventions or exposures that may impact temperament formation. Environmental factors (e.g., early life stress, parenting styles, socioeconomic conditions) that potentially influence temperament through epigenetic or psychoneuroimmunoendocrine pathways. Stress response assessments in relation to temperamental characteristics. Longitudinal studies tracking the development and stability of temperamental traits over time. Interventions or exposures that specifically target or affect psychoneuroimmunoendocrine systems in relation to temperament. PICO tags selected: Institutional Environmental Intervention; Temperament Testing; Psychostimulant Additional Information on Comparator Inclusion Criteria: This systematic review will include studies that: Define biologically relevant comparators: Traditional temperament models (e.g., Cloninger or Eysenck classifications). Baseline psychoneuroimmunoendocrine states (e.g., resting hormonal levels). Environmental conditions unexposed to epigenetic factors (e.g., control groups without psychosocial stress). Prioritize conceptually aligned comparators: Studies contrasting morphogenetic temperaments with non-epigenetic typologies. Comparisons between specific epigenetic mechanisms (e.g., DNA methylation vs. histone modifications). Exclude irrelevant comparators: Pharmacological/behavioral interventions unrelated to psychoneuroimmunoendocrine systems. Studies comparing temperaments with unrelated variables (e.g., cognitive performance). Rationale from Search Results Precision: Aligns with PRISMA guidelines ([Result 3], [Result 4]) requiring explicit comparator definitions. Bias Reduction: Excludes mismatched comparisons ([Result 1], [Result 5]). Reproducibility: Follows JBI recommendations ([Result 5]) for systematic reviews in interdisciplinary fields. Handling Non-Comparative Studies For studies without direct comparators (e.g., observational correlations), baseline biological or environmental measurements will serve as implicit comparators | "The exclusion criteria for the population in this systematic review include studies conducted on animals, participants with severe or chronic medical conditions that could significantly impact psychoneuroimmunoendocrine systems, and non-human populations. Studies that do not directly assess morphogenetic temperaments or lack data related to epigenetic mechanisms or psychoneuroimmunoendocrine systems will also be excluded." Exclusion criteria for interventions or exposures: This systematic review will exclude studies that: Lack biological mechanisms: Interventions/exposures not explicitly tied to psychoneuroimmunoendocrine systems (PNIE) or epigenetic mechanisms. Use non-relevant interventions: Pharmacological treatments, surgical procedures, or behavioral therapies unrelated to temperament modulation via PNIE/epigenetic pathways. Combine confounding factors: Interventions with mixed exposures (e.g., drug therapy + psychotherapy) where effects cannot be isolated. Focus on acute conditions: Studies examining short-term physiological responses (e.g., acute stress tests) without longitudinal temperament assessment. Employ non-standardized assessments: Interventions using unvalidated tools for measuring temperament or epigenetic changes. Target non-relevant outcomes: Exposures aimed at non-temperament outcomes (e.g., cognitive performance, physical health metrics). Include indirect mechanisms: Studies exploring general stress responses or immune function without linking to temperament typologies. Rationale Based on Search Results: Specificity: Aligns with Cochrane guidelines () requiring interventions to match predefined biological pathways (PNIE/epigenetics). Confounding: Follows examples from where combined interventions are excluded to isolate effects. Methodological rigor: Excludes non-standard tools to ensure reproducibility (). Scope: Focuses on chronic/exposure-based mechanisms per inclusión criteria This systematic review will exclude comparators that: Are not related to temperament or psychoneuroimmunoendocrine systems Involve pharmacological interventions unrelated to epigenetic mechanisms Compare temperaments with non-relevant psychological or physiological traits Use non-standardized or unvalidated assessment tools for temperament or epigenetic markers Focus solely on pathological conditions without considering normal temperament variations Involve animal models without clear translational relevance to human temperament Compare temperaments across significantly different age groups without accounting for developmental stages |
CRD42020188306 | Do Migraineurs have disturbed autonomic functioning as measured by blood pressure and heart rate variability when compared to healthy controls?
Do migraineurs have disturbed endocrinological function as measured by cortisol and the sex hormones; estrogen, progesterone and testosterone, compared to healthy controls? | Migraine Disorders, Autonomic and Endocrinological functioning withing migraineurs as compared to healthy controls. | null |
CRD420250656441 | The question guiding the review is: What is the relationship between urban living environment (indicators, combinations, patterns) and mental health? The primary objectives of the systematic review are as follows:1. To identify and synthesis evidence and assess whether significant relationship exist between urban living environments and mental health and summarise the potential mechanisms (i.e. mediators and moderators) explaining the relationship.2. To assess the combined effects of natural, built, and social environmental factors, identifying patterns or combinations of these indicators that drive relationships with mental health.3. To statistically quantified the strength of evidence for relationship between urban living environments and mental health using meta-analysis that accounted for the sample size and methodological quality of the studies. | Mental disorder; Environmental Exposure Inclusion: general population lives in urban areas, which is not limited by age, gender, occupation, or other demographic characteristics, aside from the type of residential area (urban/rural)The definition of "urban areas" in this review: The review adopts a broad definition of 'urban', including cities, towns, and wider conurbations when discussing general urban issues."Urban" will not only be measured by population density but also as a "social" entity where individuals are considered urban residents not simply by the location of their residential address but also by the majority of their interaction with the urban areas. Inclusion: We represent the urban living environment by combining physical environment (either natural or built environments) with social environment in urban areas, to include the components of physical space and the significant role of social interactions in shaping the living environment.Studies that involve at least two exposure factors, which must be indicators of urban living environment and include both physical (natural or built) and social environment indicators, will be included.Studies that combine different physical and social environment indicators to calculate a composite index (such as an urban living environment index) or measure perceptions of overall urban living environment will also be included.The specific environmental indicators are as follows:1. Natural environment: green spaces, blue spaces, ambient air pollution, noise pollution, and heat.2. Built environment: transportation systems, land use patterns and design features, and housing.3. Social environment: community socioeconomic status, social deprivation, violence/crime/safety, social capital, and social support. | Exclusion: general population lives in rural areas; studies based on regional or national samples that did not analyse participants classified as urban residents separately Exclusion: Studies will be excluded if the exposure factors only include physical environment indicators or only social environment indicators, are not quantified, or are not considered as separate predictors of mental health (like confounding factors). |
CRD42020210128 | • What are the risk predictors of PTSI among first responders during COVID-19 pandemic?
• What is the impact COVID-19 pandemic on the mental health (PTSI) of first responders?
• Which interventions are more effective in reducing the prevalence of PTSI in the first responders? | Nowadays, COVID-19 pandemics pose unique challenges to first responders, especially healthcare/ emergency services personnel. Post-traumatic stress injuries (PTSI) is considered common adverse psychological reactions among first responders (Firefighters, Police officers, Forest fire inspectors, Ambulance drivers and Paramedics). This disorder is characterized by the emergence of four symptom clusters following trauma exposure, including intrusive thoughts, avoidance of triggers, numbing or negative emotions/mood, and hyperarousal. | null |
CRD420250640888 | The overall review question is: What characterizes interventions in the existing literature that seek to provide family engagement in Forensic Mental Healthcare Settings.The qualitative conzeptualization model PICo will be applied to define the elements within the review question:The Population (P) defines as adult family members to service users aged 18 and above, who receive forensic mental healthcare, the Phenomenon of Interest (I) defines as interventions seeking to provide family engagement and the Context (Co) defines as forensic mental healthcare settings. | Family intervention Healthcare domaine, Forensic mental healthcare. Adult family members (aged 18 and above) to service users, who are cared for in forensic mental healthcare settings. Interventions seeking to provide family engagement to service useres aged 18 and above, who are cared for in forensic mental healthcare settings. | null |
CRD42024578464 | Is there evidence on the nutritional outcomes of infants born to mothers with mental illness compared to those born to mothers without mental illness? | The domain being studied -Nutritional status in infants who are born to mothers with mental illness.
Infants born to mothers with mental illness face high risks of nutritional status abnormality, which can have lifelong developmental consequences. Maternal mental health directly affects feeding practices and infant care, leading to nutritional abnormalities such as stunting, wasting, and underweight. Anthropometric measures (e.g., height-for-age, weight-for-age, weight-for-height, and mid upper arm circumference ) are crucial for assessing infant nutritional status as per WHO(World Health Organization)
Existing research has explored the relationship between maternal mental illness and infant nutrition in very few studies, often lacking comprehensive analysis. Hence our systematic review aims to bridge this gap by conducting a robust evaluation of the nutritional status outcomes in infants born to mothers with mental illness, using anthropometric measures. Hence our study will help to develop interventions for this vulnerable population. | null |
CRD42023483085 | What are the experiences of service users who participate in prison-based democratic therapeutic communities? | Therapeutic Communities (TCs) have evolved and adapted to meet population needs, including the most serious and complex offenders residing in prisons (Rawlings & Haigh, 2017). Prison based Democratic Therapeutic Communities (DTCs) are recognised as part of the UK’s Offender Personality Disorder (OPD) pathway programme, aiming to enhance the psychological health of complex offenders, as outlined in the OPD Strategy (2015). The Royal College of Psychiatrists Community of Communities (CofC) (RCP, 2023) documents all prison DTCs and specialised LD TC’s (known as TC+) that exist and are accredited within the UK: HMP Dovegate, Gartree TC, HMP Grendon, HMP Send (for women) and the Warren Hill TC. Pitt (2021) produced the first known qualitative synthesis of service user experiences of DTCs, comparing community DTCs and prison-based DTCs for people with personality disorders. However, this review only captured service users’ experiences of the TC environment and how the operational set up of the TC and activities and subsequently facilitated engagement and connection with members within both prison and community TC settings. A qualitative synthesis relating to exploring service user’s experiences of treatment, including perceived barriers and facilitators in prison-based DTCs, may further contextualise, inform and improve current practices (Seers, 2015). | null |
CRD420250655267 | How do parents of children with an intellectual disability experience and navigate their child's transition to adulthood across healthcare, education and social domains? | Intellectual Disability Intellectual Disability. Parents experience of child with ID transition to adulthood. Inclusion: Parents or primary caregivers of individuals with an intellectual disability. Individuals with an intellectual disability will be aged 16 to 40 years of age. Will include individuals if past the age of 40, if speaking about issues related to transition to adulthood.Intellectual disability is being categorised to include disorders where there is significant reduced ability to understand new or complex information, to learn new skills, with a reduced ability to cope independently, which started before adulthood. Which will include, Intellectual Disability, Down Syndrome, Rett Syndrome, Fragile X, Chromosome Syndrome, Angelman Syndrome. Qualitative Study:The transition to adulthood for individuals with intellectual disabilities (ID) is a complex and multifaceted process that extends beyond a single domain, such as healthcare or education. Unlike individuals without an ID, those with ID often experience delayed or prolonged transitions, requiring ongoing parental involvement in decision-making, service navigation, and caregiving responsibilities well into adulthood. Parents play a crucial role in facilitating this transition, yet their experiences and challenges are often overlooked in research and policy discussions.The focus of this review will be on exploring and understanding the parental experiences of individuals with an intellectual disability as they transition to adulthood. This will be parental experiences across multiple transition areas, including healthcare, education, employment and changing parental roles. | Exclusion: - Studies focusing on Intellectual disability with no parental perspective. - Studies where focus is on developmental or neurodevelopmental disorders or mental health conditions. - Studies of young child or adult children past the point of transition. |
CRD42020188823 | The aim of this meta-analysis which includes several randomized controlled trials is to evaluate the effect of Transcranial Direct Current Stimulation (tDCS) on sleep. | Sleep disorder is a major public health problem at home and aboard. It is always strongly associated with other somatic and mental health problems as well as with an increased mortality rate. Transcranial direct current stimulation(tDCS), which is a safe, convenient, and low-cost technology, has been confirmed by several studies to improve sleep problems. | null |
CRD42024506249 | The relationship between values and subjective well-being is an important topic in psychological research. Over the past few decades, psychologists have conducted extensive research on people’s subjective well-being and identified many factors influencing well-being, with values considered an important influence. The relationship between self-concept and well-being has been widely explored in social psychology. The relationship between self-enhancing values and subjective well-being has attracted scholarly attention. Some studies have found individuals with self-enhancing values are more likely to feel satisfied and happy because they focus on personal achievement and self-fulfillment and are sensitive to feelings of success and accomplishment, positively predicting subjective well-being. However, excessive pursuit of self-enhancement can lead to anxiety, stress, and dissatisfaction, negatively impacting well-being. Age and gender also significantly moderate this relationship. So what is the exact relationship between self-enhancing values and subjective well-being? In what scenarios do self-enhancing values promote or diminish well-being? To address this practical issue, the present study adopts a meta-analytic approach to explore the relationship between self-enhancing values and subjective well-being through systematic quantitative analysis of existing studies. The aim is to provide new perspectives and methods for well-being intervention and enhancement, greatly benefiting people’s well-being and psychological health. | The relationship between self-concept and well-being has been widely explored in social psychology, with scholarly attention recently turning to the link between self-enhancing values and subjective well-being. Self-enhancement values represent individuals' motivation to enhance their personal interests, emphasizing pursuit of wealth, prestige, and dominance, including both power and achievement. Current research on this relationship can be broadly categorized into three groups: on one hand, some studies suggest self-enhancing values can contribute to individuals' subjective well-being as belief in one's competence and worthiness leads to self-confidence and contentment, enhancing well-being. On the other hand, excessive self-enhancing values may also lead to anxiety, stress, and dissatisfaction, reducing subjective well-being. In addition, other studies find pursuit of power and achievement values may not relate to subjective well-being. So what exactly is the relationship? In what scenarios does it actually promote or diminish well-being? To address this practical issue, this study adopts a meta-analytic approach to explore the relationship through systematic quantitative analysis of existing studies, aiming to better understand individual well-being formation mechanisms and provide theoretical and practical guidance for enhancing well-being. | null |
CRD42020218644 | In post-stroke patients, does neurologic music therapy result in improved outcomes of mental health (depression, anxiety, sleep, behaviours) as well as cognitive function, speech or motor movement and is this reflected by physiological measures such as cardiovascular health. comparators = music listening or other non-music related therapy tasks, outcomes = speech, cognition, motor skills, behaviours, sleep, depression, anxiety, physiological biomarkers, cortisol, BDNF | Stroke and rehabilitation outcomes | null |
CRD420250650450 | 1. What is the effectiveness of SSCM for the treatment of clinical eating disorders? | Psychotherapy; Eating Disorder The use of Specialist Supportive Clinical Management (SSCM) as a psychological therapy for patients diagnosed with an eating disorder. This may be as part of a recovery focussed intervention (such as with the aim of weight restoration or symptom reduction) or a harm minimisation strategy (which may have less of a focus on weight restoration and an emphasis instead on quality of life). Participants will have a diagnosis of an eating disorder (such as Anorexia Nervosa, Bulimia Nervosa and atypical variations), based on standardised diagnostic criteria (DSM or ICD). Participants that have co-morbid psychiatric diagnoses will be included as long as they have a concurrent diagnosis of an eating disorder in it’s own right (rather than disordered eating occurring as a symptom of another disorder).Due to the need to understand the effectiveness of SSCM at a clinical and diagnostic level given the nature of commissioning structures in Eating Disorder Services in the UK and beyond, studies which include participants who self identify as having an eating disorder, or who are subclinical will not be included. Included participants will have undergone manualised SSCM therapy as a psychological intervention for their diagnosed eating disorder within any mental health setting (such as outpatient, inpatient, day patient), and in any format (group or individual therapy, remote or face to face). Whilst it is anticipated that this review will focus mainly on the care of adults (due to the current evidence base and subsequent treatment guidelines), studies including samples of either adults and/or children or adolescents will be included if deemed relevant. Identified studies will involve SSCM being delivered by a mental health professional to individuals diagnosed with an eating disorder as an evidence-based and manual lead psychological therapy (see McIntosh et al., 2005). This may be part of a recovery or harm minimisation pathway.Studies will be excluded if there is no evidence that the intervention being delivered is true to the SSCM model. Studies where SSCM is being delivered will be scrutinised for evidence that they are adhering to the therapy manual (with reference to original trial by McIntosh et al., 2005) and are receiving SSCM specific supervision. All delivery methods will be considered, such as group or individual, remote or on a face to face basis. There will be no exclusion based on number of sessions attended. Included studies may or may not have an active control (such as another therapy, treatment as usual, waiting list etc). All studies investigating outcomes or experiences of SSCM will be included even if non-controlled or non-randomised with no comparison condition. | Studies that explore the treatment of eating disorders utilising other methods (such as other therapies, non-psychological approaches or pharmacology) and do not include SSCM as a comparator will be excluded. |
CRD42025646385 | How does physical exercise (including Yoga, High intensity interval training, Aerobic Training?Resistance
Training, Behavioral weight loss ) and Cognitive behavioral therapy intervention treat adults with binge eating disorder? And the comparison of these two therapeutic effects. | Efficacy of physical exercise and cognitive behavioral therapy on depressive symptoms, binge eating frequency, and body composition in adults with binge eating disorder. | null |
CRD42014015452 | To conduct a quantitative systematic evidence synthesis to identify those models of self-care support for children and young people that are associated with reductions in health services utilisation and cost, without compromising health outcomes. | Long term conditions in children and young people. | null |
CRD42024623631 | While the risks of polypharmacy in elderly populations are well-documented globally, there is a lack of research specifically characterizing these risks within the context of China's unique healthcare system and demographic characteristics. Furthermore, the influence of seasonal variations and gender differences on drug combination patterns among elderly Chinese patients remains largely unexplored. Existing studies predominantly focus on Western populations, leaving a significant gap in understanding the specific needs and challenges faced by the elderly in China.The aim of this research is to systematically evaluate the prevalence and associated risks of common drug combinations among elderly patients in Central China, with a particular focus on identifying high-frequency risk combinations, and to analyze the impact of seasonality and gender on these patterns. Through this analysis, the study aims to provide an evidence-based basis for developing tailored medication management strategies that address the unique needs of this population, ultimately improving the safety and effectiveness of pharmacotherapy for elderly patients in Central China. | Polypharmacy, the concurrent use of multiple medications, is increasingly prevalent among elderly patients, particularly those with multiple chronic conditions. This phenomenon is driven by the aging global population and the rising prevalence of chronic diseases such as cardiovascular disease, diabetes, and mental health disorders. In China, the prevalence of polypharmacy among older adults is substantial, mirroring global trends. While often necessary to manage complex health needs, polypharmacy significantly increases the risk of drug-drug interactions, adverse drug events (ADEs), and medication non-adherence, leading to negative health outcomes, including increased hospitalizations, reduced quality of life, and higher mortality rates. Current research on polypharmacy has primarily focused on Western populations. There is a notable gap in understanding the specific patterns, risks, and contributing factors associated with polypharmacy in the Chinese elderly population, especially considering the unique aspects of China's healthcare system and traditional medicine practices. Furthermore, the impact of seasonality and gender differences on polypharmacy patterns in this population remains largely unexplored. Addressing this gap is crucial for developing targeted interventions and improving medication safety for elderly patients in China. | null |
CRD420250655105 | The review question focuses on the prevalence of consumption of Cannabidiol (CBD) among both clinical and non-clinical samples, as well as which variables are associated with higher prevalence.For this purpose, those peer-reviewed articles reporting CBD prevalence rates were included, regardless country and age group. | Cannabidiol; Prevalence; Abuse The review will be focused on Cannabidiol (CBD) use in different countries and age groups. All population will be included.Exclusion criteria: NA NA | null |
CRD42024520440 | What are school nurses’ experiences of mental health promotion among young people in school and student health care? | The phenomena of interest is the nurses' experiences of mental health promotion among young people. Public health nurses in school and student health care context. Experiences of mental health promotion among young people Not applicable. | null |
CRD42023470954 | To estimate the prevalence of sexual dysfunctional in Medical Staff.
To estimate the related factors of sexual dysfunctional in medical staff | The condition being studied in this systematic review is sexual dysfunction in medical staff. Sexual dysfunction is a broad term that encompasses any problems with sexual desire, arousal, orgasm, or satisfaction. Sexual dysfunction can affect both men and women, and can have various causes, such as physical, psychological, interpersonal, or environmental factors. Sexual dysfunction can have a negative impact on the quality of life, well-being, and mental health of individuals and their partners.
Medical staff are a group of health care workers who provide medical services to patients, such as doctors, nurses, pharmacists, dentists, etc. Medical staff are exposed to high levels of stress, workload, burnout, and trauma in their work environment, which can affect their sexual functioning and activity. Medical staff may also face barriers to seeking help for their sexual problems, such as stigma, lack of time, or lack of resources. Therefore, it is important to study the prevalence of sexual dysfunction in medical staff and identify the risk factors and interventions that can improve their sexual health. | null |
CRD420251015932 | The objective of this systematic review and meta-analysis is to evaluate the effects of intermittent exercise interventions at varying intensities on physical and mental health outcomes in sedentary populations. Specifically, the review aims to synthesize evidence from randomized controlled trials and quasi-experimental studies to: | Inclusion: Adults and adolescents (≥18 years) from any population group who engage in prolonged sedentary behavior, defined as sitting for ≥6 hours per day or classified as sedentary using validated tools (e.g., the International Physical Activity Questionnaire). Participants may be healthy or at risk of sedentary-related health conditions. Studies conducted in workplace, school, home, or community settings will be included. Exclusion: Children (<18 years), individuals with severe physical or medical limitations that prevent participation in physical activity (e.g., advanced cardiovascular disease, mobility impairments), and populations with conditions requiring specialized interventions not related to sedentary behavior. Studies without clear classification of sedentary behavior will also be excluded. Exercise; Physical activity; Exercise therapy The intervention examined in this review is exercise, defined as short bouts of low- to moderate-intensity physical activity (e.g., walking, stretching, bodyweight exercises) aimed at breaking up prolonged sedentary time. Eligible studies must assess interventions that explicitly disrupt sedentary behavior multiple times throughout the day. Comparators may include sedentary control conditions, health education, or traditional continuous exercise. Studies that focus solely on continuous exercise without sedentary interruptions, lack clear intervention details (e.g., frequency, duration, or intensity), or combine fragmented exercise with other interventions without separately analyzing its effects will be excluded. PICO tags selected: Behavioral Therapy; Non-Pharmacological Interventions; Education | null |
CRD42025635861 | What are the most effective strategies to prevent mental health disorders and promote mental well-being in military personnel? | Mental health disorders | null |
CRD42024585707 | In order to clarify the overall prevalence of mental health problems in Chinese raw recruits and further analyze its influencing factors, a meta-analysis will be conducted on relevant studies retrieved from 2000 to 2024. | Chinese raw recruits, mental health | null |
CRD420250641344 | What is the impact of migraine on workplace productivity and the cost of lost productivity in relation to developing and developed countries? | Migraine patients experience migraine symptoms such as headache, nausea, vomiting and aura that occur in attacks. This situation affects their daily living activities, psychological state, and work life. The researchers will work on migraine patients in this review.Inclusion criteria1) studies investigating migraine2) clinical trials, observational studies (cross-sectional, cohort studies), case series3) studies investigating workplace burden, disability, quality of life or work productivity.Exclusion criteria:1) animal studies2) studies investigating people under 18 years of age3) abstracts, case-reports or series, letters to the editor, review articles, conference proceedings or articles published in non-peer-reviewed journals, theses, dissertations4) headaches other than migraine Migraine is considered by the World Health Organization (WHO) as a neurological disease that causes serious burden on individuals and the health system. Migraines can affect people's ability to work through decreased productivity. Individuals continue to work despite the debilitating symptoms that may arise due to the obligations of the system, which varies from country to country. Loss of productivity due to headaches can impact people's careers, finances, relationships, and mental health. It causes economic losses to businesses and society.Study inclusion criteria:1) studies investigating migration2) clinical trials, observational studies (cross-sectional, cohort studies), case series3) studies investigating workplace burden, disability, quality of life or work productivity.Exclusion criteria of the study:1) animal studies2) studies investigating people under 18 years of age3) abstracts, case-reports or series, letters to the editor, review articles, conference proceedings or articles published in non-peer-reviewed journals, theses, dissertations4) headaches other than migraine Not applicable | null |
CRD420250620512 | Population - older adults (age over 65) worldwide.Exposure - a range of ambient temperatureComparison - Comparisons between places or time periods at relatively lower or higher temperaturesOutcome - cognitive function (based on any validated measure of cognition)Study Design - Population / Cohort studies, case-control and randomised control trials. | Congitive function in older adults across different domains assessed using formal congitive assessment. Including memory, language and visuospacial and executive function. Older adults, ages >= 65. If the majority or patients within the study are over our target age the studies will also be included. Participant with other health conditions (where specified) including dementia/other cognitive disorders with be included. Ambient temperature. Including studies using weather data, directly measured outdoor and indoor temperature. Not including studies only looking at body temperatres or studies looking at subjective temperature / thermal comfort. Comparison expected to be largely within the same population (comparing cognition / outcomes at different times/ in different temperature conditions) or between populations (comparing outcomes between populations in different climates). | null |
CRD42024612300 | What is the prevalence of burnout among healthcare workers in India? | Burnout syndrome; Healthcare Professional ; Mental state; Prevalence Burnout syndrome among healthcare workers, characterized by:Emotional exhaustionDepersonalizationReduced personal accomplishment Inclusion:Healthcare workers in IndiaDoctorsNursesAllied health professionalsHealthcare administratorsBoth private and public sectorsAll age groupsBoth gendersExclusion:Medical/nursing studentsHealthcare workers outside IndiaRetired healthcare workersNon-healthcare staffVoluntary healthcare workers Burnout measured by validated instruments:Maslach Burnout Inventory (MBI)Copenhagen Burnout Inventory (CBI)Oldenburg Burnout Inventory (OLBI)Other validated burnout measures Not applicable for prevalence studiesFor associated factors: Healthcare workers without burnout | null |
CRD42024608752 | What published and peer-reviewed evidence exists for the relationship between the expression of dopamine, glutamate, and GABAergic neurotransmitter receptor subtypes in peripheral blood and Major Depressive Disorder (MDD) in humans? | Major Depressive Disorder (MDD) is a common and debilitating mental health condition characterized by persistent low mood, loss of interest or pleasure in daily activities, and a range of cognitive and physical symptoms, including fatigue, impaired concentration, changes in appetite, and sleep disturbances. MDD affects individuals across various age groups and has substantial impacts on quality of life, social functioning, and overall health. | null |
CRD420251004987 | To find out which interventions were carried out for intervening sleep, fatigue and depression all at once and to analyze the effects of those interventions quantitatively and qualitatively. | Adults who are 18 or older and who have an impaired mental health status like depression, insomnia.... Not limited. If the interventions are applied to the participants for improving the problems of sleep, fatigue and depression, any intervention can be included. | Adolescents, Youth |
CRD420250651806 | Primary objectives | Psychometric Testing; Quality of Life The domain being studied is the suitability and performance of quality-of-life outcome measures for adult psychiatric inpatient populations. The population of interest are adult inpatients (psychiatric). The review is not restricted by country, outcome measures used with psychiatric inpatient populations worldwide will be eligible. Psychometric Testing; Assessment Of Quality Of Life Papers which include the psychometric properties of the quality-of-life outcome measurement tool, for example, validation studies. PICO tags selected: Psychometric Testing Using different psychometric properties, such as reliability indices, the identified outcome measures will be compared using the COSMIN OMI guideline for systematic reviews (Elsman et al., 2024). | Studies that do not include an adult inpatient psychiatric population will be excluded. For example, studies on adolescents or older adults in inpatient psychiatric settings, studies that are not set in adult inpatient psychiatric settings, e.g. community mental health, physical rehabilitation, medical wards. Adolescents, older adults, physical health, learning disability, general ward populations, physical rehabilitation e.g. stroke, cognitive impairment, eating disorder units, addiction/detox centres, and forensic populations. Studies which do not report on or include psychometric properties of the outcome measure. Interventional studies, for example, studies which use an outcome measure for pre and post intervention evaluation but do not evaluate measurement properties. |
CRD420250637840 | Primary question: Are VR relaxation and wellbeing interventions effective at reducing anxiety? Secondary question: Within studies that have used a control group, is there an effect of VR at reducing anxiety?Other questions:What groups of people have the methodologically robust studies of VR relaxation for anxiety been carried out on? (i.e. relating to age, gender identity, sex, ethnicity, occupational status, mental health or physical health diagnoses)What have the interventions involved, i.e., the virtual experience, the method of delivery etc? | Anxiety Anxiety is a universally experienced human emotion, which involves feelings of dread of anticipatory events and worry. While adaptive in some contexts, heightened levels of anxiety in the general population, alongside anxiety disorders in the clinical population, pose significant health and economic challenges, necessitating innovative interventions. Inclusion criteria are studies with general population and clinical samples, in both paediatric and adult physical and mental health settings. No populations will be excluded. Virtual Reality VR interventions usually involve the use of a head-mounted display or VR 'goggles', that show 360' videos and create an immersive experience for the users, often with audio input. This creates a sense of presence in the environment, as if the user was actually in the VR environment. VR assisted therapies have emerged as a promising intervention for targeting anxiety through two distinct approaches: 1) VR assisted exposure therapy, primarily used in clinical treatment to help people with anxiety disorders and 2) VR assisted relaxation and wellbeing experiences, which aim to promote mental health and can be used in both clinical and non-clinical populations (Bell et al., 2024). VR relaxation therapies focus on immersing users in soothing and pleasant virtual environments designed to reduce stress and promote relaxation. While VR exposure therapy has a well-established evidence base demonstrating its effectiveness (Powers & Emmelkamp, 2008), the literature on VR relaxation and wellbeing interventions is comparatively underdeveloped (Riches et al., 2021). Inclusion criteria: studies that use head-mounted displays to present immersive, three-dimensional virtual reality environments aimed to reduce anxiety. PICO tags selected: Active control; Usual Care Inclusion criteria: studies using experimental designs that include comparisons with non-virtual reality interventions such as a 2D equivalent or treatment as usual will be included. | Exclusion criteria: studies involving VR exposure therapy; studies that do not use head-mounted displays. |
CRD42022304029 | What is the association between mental health issues, depression and hepatocellular carcinoma in patients diagnosed with liver cancer? | Patients with hepatocellular carcinoma are commonly associated with mental health disorders, including depression. In this review, we will be analysing the effects of depression and other mental health disorders in affecting the patients. | null |
CRD42024541365 | Broad Review Question: What are the key insights from health professionals and patients regarding pharmacist-led MNS services in low- and middle-income countries (LMICs), and how can these insights contribute to the enhancement of mental healthcare in these settings?
Specific research questions:
1. What types of mental health services are provided by pharmacists in LMICs?
2. What are the perceptions and expectations of patients and healthcare professionals regarding pharmacist-led mental health services in LMICs?
3. What are the challenges faced by pharmacists in providing mental healthcare in LMICs?
4. What factors can facilitate the delivery of pharmacist-led mental health services in these settings? | Phenomenon of Interest:
Pharmacist-led mental health services encompassing routine practices related to mental healthcare, such as counselling, medication management, education, and advocacy, as well as specific interventions initiated by pharmacists to improve mental health outcomes. | null |
CRD42024599897 | The primary objective of this meta-analysis is to systematically review and quantitatively synthesize the existing literature on electrophysiological microstates in individuals with Autism Spectrum Disorder (ASD). we aim to identify Consistent Patterns determine if there are consistent electrophysiological microstate patterns that differentiate individuals with ASD from typically developing controls. Explore the variability in findings across studies to understand the factors contributing to heterogeneity, such as age, gender, severity of ASD symptoms, and methodological differences. And offer a comprehensive overview that may contribute to the development of improved diagnostic tools for ASD.The primary objective of this meta-analysis is to systematically review and quantitatively synthesize the existing literature on electrophysiological microstates in individuals with Autism Spectrum Disorder (ASD). we aim to identify Consistent Patterns: Determine if there are consistent electrophysiological microstate patterns that differentiate individuals with ASD from typically developing controls. Examine Heterogeneity: Explore the variability in findings across studies to understand the factors contributing to heterogeneity, such as age, gender, severity of ASD symptoms, and methodological differences. | Preliminary results have been obtained in the field of EEG microstates in ASD, and based on our search results in six databases (PubMed, WoS, EMBASE, EBSCO, Cochrane Library, and PsycINFO), 10 studies were initially included. Some potential consistent advances have been identified in these studies, such as differences in the duration and frequency of microstate B between the ASD group and the healthy control group. However, these results are also contradictory, and some studies cannot reproduce these results. Moreover, there are differences in the study design and age of the enrolled subjects, and heterogeneity cannot be tested yet. Therefore, current research will further clarify the differences in these indicators and the heterogeneity between different studies. | null |
CRD42023457722 | Regarding the language used in the review protocol, the term ‘autism’ will be used to encompass all diagnostic terms related to this, including but not limited to: Autism Spectrum Disorder, Asperger’s Syndrome and Pervasive Developmental Disorder.
Review questions:
1. How do young people describe the development of their identity following an autism diagnosis?
2. What do young people consider to be factors related to the development of their identity after receiving an autism diagnosis? | Identity development following diagnosis of Autism in young people.
Autism will be defined as any reported clinical or research diagnosis of Autism Spectrum Disorder, or associated historic diagnoses such as Asperger’s syndrome and Pervasive Developmental Disorder.
Identity will be broadly defined using the framework set out by Holland et al. (1998) as ‘the way a person understands and views himself, and is often viewed by others’. It will also draw on social identity theory to consider how the social identity of an individual is influenced by group membership, and perceived status of those groups (Turner, 1999).
The review will take a broad stance on the definition of identity and therefore any terms that are related to how one considers ‘the self’ (e.g., self-concept and self-esteem) will be considered as covering a sufficiently overlapping construct as to be incorporated under the broader identity definition, and therefore included in the review. | null |
CRD420251012381 | To explore the effects of Baduanjin exercise on the psychological health and quality of life of cancer patients, providing a scientific basis for rehabilitation interventions for cancer patients. | Adult patients with cancer(as diagnosed using histopathological examination) Exercise therapy Baduanjin exercise is characterized as a traditional fitness modality that integrates physical movement, respiratory regulation, and psychological modulation. PICO tags selected: Usual Care all experimental studies including randomized control trials and non-randomized controlled trial | Adolescents (under 18 years of age) opinion to editors, case studies, theses and dissertations, study protocols, grey literature |
CRD420250646791 | What are the dropout and follow-up rates in elective and emergency hand surgery trials, and what factors contribute to patient attrition in these studies? | The review focuses on dropout and follow-up rates in clinical trials involving elective and emergency hand surgery. Hand surgery encompasses a wide range of procedures aimed at restoring function, alleviating pain, and improving outcomes in conditions affecting the hand and wrist. Elective hand surgery includes procedures such as carpal tunnel release, tendon repair, and joint arthroplasty, while emergency hand surgery involves interventions for acute trauma, including open fractures, flexor tendon injuries, and digital replantation. Given the functional and occupational significance of the hand, adherence to follow-up is critical for optimising postoperative recovery. However, patient attrition is a known challenge in surgical trials, and this review aims to identify the factors influencing dropout rates and follow-up adherence in both elective and emergency settings. Adult patients (≥18 years old) undergoing elective or emergency hand surgery within the context of randomised controlled trials (RCTs) Eligible participants will include those undergoing elective procedures, such as carpal tunnel release, tendon repair, joint arthroplasty, and Dupuytren’s contracture surgery, as well as emergency procedures, including open fractures, flexor tendon injuries, replantation, and crush injuries. The primary comparison in this review will be between elective and emergency hand surgery trials to evaluate differences in dropout rates and follow-up adherence. Studies may include comparisons between different surgical techniques, follow-up methods, or patient demographics that influence attrition. | null |
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PROSPERO Inclusion/Exclusion Criteria Dataset
This dataset is a curated and preprocessed collection of clinical research objectives and their corresponding inclusion and exclusion criteria, extracted from the PROSPERO international prospective register of systematic reviews.
Description
The dataset was constructed to support fine-tuning of large language models (LLMs) for tasks involving the automated generation of eligibility criteria based on research objectives. It contains English-language research objectives from systematic review protocols across three domains:
- Mental health
- Diagnostics
- Therapeutics
Dataset Structure
Each row in the dataset corresponds to one study protocol and contains:
Study_ID: The unique identifier from PROSPERO (e.g., CRD420250616527)Objectives: The research objective(s) of the systematic reviewIncluded: The criteria defining which participants/studies are eligible for inclusionExcluded: The criteria used to disqualify participants/studies from inclusion
Use Case
This dataset is ideal for training or fine-tuning LLMs (like T5, Mistral, LLaMA) on:
- Generating inclusion/exclusion criteria from research objectives
- Biomedical text-to-text reasoning tasks
- Automating systematic review assistance and meta-research workflows
Format
- File type: CSV (
utf-8) - Fields:
Study_ID,Objectives,Included,Excluded - Suggested fields for fine-tuning:
input_text: Prompt generated fromObjectivesoutput_text: "Inclusion: ... Exclusion: ..." combined string
License & Attribution
Data is sourced from PROSPERO, a publicly accessible database, and is intended for educational and research purposes only. Please cite the original PROSPERO records when using this dataset in any published work.
🙌 Created By
Sanaa as part of her mission to automate and enhance systematic literature reviews using AI. email: [email protected]
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