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|---|---|---|---|---|---|---|---|
Minimizing DON contamination in grains is a major goal of Fusarium Head Blight (FHB) research community.
| null | null |
1 Response to Reviewer 1 Comments Point 1: I would like to suggest authors label inoculation points in Figure 1, which could give readers a clear view of three different inoculation methods.
| null | null |
toxins14060409_makarova
| 0 |
This may be true, but far more studies have confirmed this link than have refuted it.
| null | null |
The IFITM3 blot shows wide variability with no pattern from one hour to the next, and yet the conclusion is that there is no change in IFITM3 levels during this time period.
| null | null |
v11060548_makarova
| 0 |
Figure 1 should be labeled as to what treatments are used in panels A-E. As it is now, the figure on its own cannot possibly be interpreted without the legend.
| null | null |
d. Figure 2B - Western blot examining levels of IFITM3 should include 24 hpi to correlate with the data presented in Figure 1.
| null | null |
v11060548_makarova
| 0 |
There are few clarifications that would strengthen the overall manuscript.
| null | null |
Additional minor comments on the figures include: a.
| null | null |
v11060548_makarova
| 0 |
At later timepoints is the NP stain nuclear as expected, is this simply a delay in replication?
| null | null |
Supplemental figures should be included in the main text.
| null | null |
v11060548_makarova
| 0 |
There are few clarifications that would strengthen the overall manuscript.
| null | null |
d. Figure 2B - Western blot examining levels of IFITM3 should include 24 hpi to correlate with the data presented in Figure 1.
| null | null |
v11060548_makarova
| 0 |
At later timepoints is the NP stain nuclear as expected, is this simply a delay in replication?
| null | null |
Additionally, the role of cholesterol in IFITM3’s mechanism of action has been largely disproven by the field, and reference 52 seems to have been misused in line 73.
| null | null |
v11060548_makarova
| 0 |
Using super-resolution microscopy the authors show colocalization of IFITM3 with influenza viral nucleoprotein and early endosomal proteins.
| null | null |
c. Labels or zoomed out images from those presented in Figure 3 and 7 are needed to orient the reader to where within a cell the colocalization is observed.
| null | null |
v11060548_makarova
| 0 |
If this is not acceptable we will make the changes in final revision.
| null | null |
IFITM3 protein increased significantly after longer infection times such as 24 h p.i.
| null | null |
v11060548_makarova
| 0 |
Furthermore, the authors need to examine the literature more carefully, as previous studies have indeed shown that IFITM3 knockdown in A549 cells increases influenza virus infection, e.g., Lin, Cell Reports, 2013.
| null | null |
At later timepoints is the NP stain nuclear as expected, is this simply a delay in replication?
| null | null |
v11060548_makarova
| 0 |
Lines 227/228: This sentence is misleading as the references cited are not contradictory, nor are they unclear as to IFITM3 possessing antiviral activity.
| null | null |
Additional minor comments on the figures include: a.
| null | null |
v11060548_makarova
| 0 |
This helix and neighboring palmitoylation sites are among the most highly conserved residues among IFITMs from all species.
| null | null |
Additionally, a second SNP in the IFITM3 promoter has also been linked to severe flu.
| null | null |
v11060548_makarova
| 0 |
At later timepoints is the NP stain nuclear as expected, is this simply a delay in replication?
| null | null |
This does not appear to increase post infection as was shown previously.
| null | null |
v11060548_makarova
| 0 |
They show that IFITM3 clusters within 1 h of influenza virus infection, prior to increases in the protein’s levels as induced by the infection.
| null | null |
qPCR is acceptable, but an IFITM3 Western would be better, particularly since the antibody is readily available.
| null | null |
v11060548_makarova
| 0 |
These IFITM3 clusters were found to correlate with restriction of virus infection and to co-localize with incoming virus.
| null | null |
There are few clarifications that would strengthen the overall manuscript.
| null | null |
v11060548_makarova
| 0 |
Lines 67-73 The inhibition of virus membrane fusion by IFITM3 has been attributed to the presence of a palmitoylated amphipathic helix within IFITM3 (Chesarino, EMBO Reports, 2017).
| null | null |
There are few clarifications that would strengthen the overall manuscript.
| null | null |
v11060548_makarova
| 0 |
Using super-resolution microscopy the authors show colocalization of IFITM3 with influenza viral nucleoprotein and early endosomal proteins.
| null | null |
In addition, the movie does not provide any details on cellular features and a viewer is left wondering where the foci are coming from and going.
| null | null |
v11060548_perova
| 0 |
The NP stain in HSAEpCs is only shown to be cytoplasmic, inclusion of an uninfected control would demonstrate specificity of the staining.
| null | null |
Furthermore, the authors need to examine the literature more carefully, as previous studies have indeed shown that IFITM3 knockdown in A549 cells increases influenza virus infection, e.g., Lin, Cell Reports, 2013.
| null | null |
v11060548_perova
| 0 |
d. Figure 2B - Western blot examining levels of IFITM3 should include 24 hpi to correlate with the data presented in Figure 1.
| null | null |
The largest concern is regarding the colocalization of IFITM3 and Rab11A.
| null | null |
v11060548_perova
| 0 |
The NP stain in HSAEpCs is only shown to be cytoplasmic, inclusion of an uninfected control would demonstrate specificity of the staining.
| null | null |
For a review of these studies, see Zani, Current Clin Microbiol Reports, 2018, though the primary articles should be cited.
| null | null |
v11060548_perova
| 0 |
Supplemental figures should be included in the main text.
| null | null |
This helix and neighboring palmitoylation sites are among the most highly conserved residues among IFITMs from all species.
| null | null |
v11060548_perova
| 0 |
qPCR is acceptable, but an IFITM3 Western would be better, particularly since the antibody is readily available.
| null | null |
d. Figure 2B - Western blot examining levels of IFITM3 should include 24 hpi to correlate with the data presented in Figure 1.
| null | null |
v11060548_perova
| 0 |
Additionally, the role of cholesterol in IFITM3’s mechanism of action has been largely disproven by the field, and reference 52 seems to have been misused in line 73.
| null | null |
Following the suggestion of this reviewer, we have removed the movie in the revised version.
| null | null |
v11060548_perova
| 0 |
Figure 3A: Why is there so much IFITM3 present in the uninfected cells?
| null | null |
At later timepoints is the NP stain nuclear as expected, is this simply a delay in replication?
| null | null |
v11060548_perova
| 0 |
Figure 4: Label the figure so that it can be interpreted independent of the legend.
| null | null |
Further, they observed that the IFITM3 clusters that form early in infection are at early endosomes and progress to late endosomes and lysosomes as infection proceeds, consistent with IFITM3 directing incoming virus to degradative compartments.
| null | null |
v11060548_perova
| 0 |
Furthermore, the authors need to examine the literature more carefully, as previous studies have indeed shown that IFITM3 knockdown in A549 cells increases influenza virus infection, e.g., Lin, Cell Reports, 2013.
| null | null |
In addition, the movie does not provide any details on cellular features and a viewer is left wondering where the foci are coming from and going.
| null | null |
v11060548_perova
| 0 |
Lines 227/228: This sentence is misleading as the references cited are not contradictory, nor are they unclear as to IFITM3 possessing antiviral activity.
| null | null |
Figure 5A/C: Label the figure so that it can be interpreted independent of the legend.
| null | null |
v11060548_perova
| 0 |
If this is not acceptable we will make the changes in final revision.
| null | null |
This study provides imaging of the antiviral protein IFITM3 at endogenous levels and at super-resolution in the context of influenza virus infection.
| null | null |
v11060548_perova
| 0 |
Further, the studies which failed to find an association were generally performed in populations in which the SNP is almost non-existent.
| null | null |
Therefore the inclusion of the movie examining the colocalization of Rab11A GFP, IFITM3-SNAP, and labeled virion seems completely unnecessary.
| null | null |
v11060548_perova
| 0 |
Furthermore, the authors need to examine the literature more carefully, as previous studies have indeed shown that IFITM3 knockdown in A549 cells increases influenza virus infection, e.g., Lin, Cell Reports, 2013.
| null | null |
Additional minor comments on the figures include: a.
| null | null |
v11060548_perova
| 0 |
This may be true, but far more studies have confirmed this link than have refuted it.
| null | null |
Figure 5A/C: Label the figure so that it can be interpreted independent of the legend.
| null | null |
v11060548_perova
| 0 |
Following the suggestion of this reviewer, we have removed the movie in the revised version.
| null | null |
Furthermore, the authors need to examine the literature more carefully, as previous studies have indeed shown that IFITM3 knockdown in A549 cells increases influenza virus infection, e.g., Lin, Cell Reports, 2013.
| null | null |
v11060548_perova
| 0 |
Author Response Thank you very much for your support and help.
| null | null |
Authors may provide data in the supporting information file.
| null | null |
w14030367_perova
| 0 |
The BAC biofilter can remove the PPCPs, and then the following UF can reject micro-organisms and particles flowing out from the biofilter to ensure the quality of drinking water.
| null | null |
Please target the specific gap such as 2015-2021 etc Response 3:
| null | null |
w14030367_perova
| 0 |
Techno-economic assessment of Minimal Liquid Discharge (MLD) treatment systems for saline wastewater (brine) management and treatment.
| null | null |
The reviewer suggests statistical analysis using a t-test (Raw water- BAC-Effluent and Raw water – BAC/UF-effluent).
| null | null |
w14030367_perova
| 0 |
In the present form conclusion is very weird.
| null | null |
Response 7: Thank you very much for your kind reminder.
| null | null |
w14030367_perova
| 0 |
In the present form conclusion is very weird.
| null | null |
I can see very well-defined experiments and produced good results.
| null | null |
w14030367_perova
| 0 |
The two-stage biofilms located in the activated carbon column and on the UF membrane synergistically, can be conducive to the removal performances.
| null | null |
Point 14: Please use one style for units such as m3/h or m3h-1 Please revise your paper accordingly since some issue occurs on several spots in the paper.
| null | null |
w14030367_perova
| 0 |
Size exclusion is considered the primary removal mechanism for the UF.
| null | null |
The manuscript could be accepted for publication after a minor revision.
| null | null |
w14030367_perova
| 0 |
Response 11: Thanks very much for this comment.
| null | null |
They also discussed their results in detail and put the difference in their results compared to the data with the literature.
| null | null |
w14030367_perova
| 0 |
Point 5: Conclusion: Make it as one or two paragraphs.
| null | null |
Point 5: Line 53-55: “The combined process with ultrafiltration may be another promising choice, featuring a comparable removing performance as the nanofiltration and low operational cost”.
| null | null |
w14030367_perova
| 0 |
Two native English-speaking colleagues help us verify the manuscript.
| null | null |
Results seem to be related to a unique experiment.
| null | null |
w14030367_perova
| 0 |
Response 5: Thanks very much for this comment.
| null | null |
Study and evaluation of the characteristics of saline wastewater (brine) produced by desalination and industrial plants.
| null | null |
w14030367_perova
| 0 |
Response 6: Thanks very much for this comment.
| null | null |
Response to Reviewer 4 Comments Point 1: Authors should avoid abbreviations in the title and the abstract.
| null | null |
w14030367_perova
| 0 |
Point 9: Please check the abbreviations of words throughout the article.
| null | null |
However, in the case of the PPCPs with a small molecular weight (typically < 600 Da), UF membranes also cannot effectively reject these PPCPs, but nanofiltration and reverse osmosis are able to remove these PPCPs based on the thin-film composite”.
| null | null |
w14030367_perova
| 0 |
The article topic is intriguing and promising in the area.
| null | null |
Response 13: Thank you very much for your kind reminder.
| null | null |
w14030367_perova
| 0 |
It was found that the BAC unit 25 played a key role in PPCPs removal and the UF unit also degraded them by the biomass on UF 26 membranes.
| null | null |
The BAC biofilter can remove the PPCPs, and then the following UF can reject micro-organisms and particles flowing out from the biofilter to ensure the quality of drinking water.
| null | null |
w14030367_perova
| 0 |
In the present form conclusion is very weird.
| null | null |
: +86 15765532017; E-mail: [email protected] (J. Wang) 14 Abstract： Biological activated carbon (BAC) biofilter coupling ultrafiltration (UF) is a promising 15 process for the treatment of surface water contaminated by pharmaceutical and personal care prod- 16 ucts (PPCPs).
| null | null |
w14030367_perova
| 0 |
The comparison of previous research with existing research findings was added in the final part of the results and discussion.
| null | null |
Response 9: Thanks very much for this comment.
| null | null |
w14030367_perova
| 0 |
Response 8: Thanks very much for this comment.
| null | null |
“The combined process with ultrafiltration may be another promising choice, featuring a comparable removing performance as the nanofiltration and low operational cost”.
| null | null |
w14030367_perova
| 0 |
If possible, please add at least one paragraph.
| null | null |
Response 2: Thank you very much for your kind reminder.
| null | null |
w14030367_perova
| 0 |
Please revise your paper accordingly since some issue occurs on several spots in the paper.
| null | null |
43 Citation: Wanga, Q.; Tanga, X.; Zenga, W.; Wangb, F.; Gongb, W.; Chena, J.; Wanga, J.; Lia, G.; Lianga, H. Pilot-scale biological activated carbon filtration-ultrafiltration (BAC-UF) system for removing pharmaceutical and personal care products (PPCPs) from surface wa- ter.
| null | null |
w14030367_perova
| 0 |
Point 9: Point 6: Why the same trend of increase or decrease in graphs (Fig.
| null | null |
Sorry, but I don't see why UF can reject viruses and bacteria but not PPCPs.
| null | null |
w14030367_perova
| 0 |
Point 9: Point 6: Why the same trend of increase or decrease in graphs (Fig.
| null | null |
Response 6: Thanks very much for this comment.
| null | null |
w14030367_perova
| 0 |
Greetings, Editor thank you for providing me with the opportunity to review the article.
| null | null |
Please clarify, why ultrafiltration cannot remove the PPCPs since it can remove bacteria and viruses.
| null | null |
w14030367_perova
| 0 |
Please also see the attached file for my corrections/comments.
| null | null |
Size exclusion is considered the primary removal mechanism for the UF.
| null | null |
w14030367_perova
| 0 |
Two native English-speaking colleagues help us verify the manuscript.
| null | null |
The comparison of previous research with existing research findings was added in the final part of the results and discussion.
| null | null |
w14030367_perova
| 0 |
Point 3: Introduction section must be written on more quality way, i.e., more up-to-date references addressed.
| null | null |
Generally, many PPCPs 41 flow through conventional water treatment processes with little degradation due to their 42 persistency or/and the continuous introduction [5].
| null | null |
w14030367_perova
| 0 |
The concentrations and diversities complicate the associated detec- 40 tion and even create challenges for water purification processes.
| null | null |
The same trend (Figure 2) was mainly due to the stable removal ability of BAC and UF for organics, causing the removal restriction.
| null | null |
w14030367_perova
| 0 |
Response to Reviewer 4 Comments Point 1: Authors should avoid abbreviations in the title.
| null | null |
Point 3: References should be according to the journal format.
| null | null |
w14030367_perova
| 0 |
Please consider these at end of this sentence……The oxidation method exhibited a fast reaction speed and high removal efficiency…(i) Role of nanomaterials in the treatment of wastewater: A review (ii) Advances and challenges in developing efficient graphene oxide-based ZnO photocatalysts for dye photo-oxidation.
| null | null |
Response 14: Thank you very much for your kind reminder.
| null | null |
w14030367_perova
| 0 |
If possible, please add at least one paragraph.
| null | null |
The study was carried out in the pilot-scale BAC-UF process with a treatment capacity of 0.16 m3/h.
| null | null |
w14030367_perova
| 0 |
The BAC biofilter can remove the PPCPs, and then the following UF can reject micro-organisms and particles flowing out from the biofilter to ensure the quality of drinking water.
| null | null |
Point 3: Line 46-52: & line 84-85 “Ultrafiltration (UF) as an emerging alternative technology to conventional water treatment processes, has been widely used to remove pollutants such as particles, colloids, bacteria, and viruses, thus reducing the risk of water-borne diseases [10].
| null | null |
w14030367_perova
| 0 |
Water 2022, 13, x. https://doi.org/10.3390/xxxxx Academic Editor(s): Received: date Accepted: date Published: date Publisher’s Note: MDPI stays neu- tral with regard to jurisdictional claims in published maps and institu- tional affiliations.
| null | null |
The authors reported the results with an average value and standard deviation.
| null | null |
w14030367_perova
| 0 |
However, the long-term pilot-scale study is urge to be investigated.
| null | null |
Point 8: The main objective of the work must be written on the more clear and more concise way at the end of introduction section.
| null | null |
w14030367_perova
| 0 |
Response 8: T Thanks very much for this comment.
| null | null |
The two-stage biofilms located in the activated carbon column and on the UF membrane synergistically, can be conducive to the removal performances.
| null | null |
w14030367_perova
| 0 |
Response 10: Thank you very much for your kind reminder.
| null | null |
After the gas scrubbing and the hydraulic backwashing, the dissolved oxygen detection of the effluent was carried out, resulting in the above results for dissolved oxygen.
| null | null |
w14030367_perova
| 0 |
Why is the standard deviation of Erythromycin showing a high value?
| null | null |
The comparison of previous research with existing research findings was added in the final part of the results and discussion.
| null | null |
w14030367_perova
| 0 |
Response 7: Thank you very much for your kind reminder.
| null | null |
The BAC biofilter can remove the PPCPs, and then the following UF can reject micro-organisms and particles flowing out from the biofilter to ensure the quality of drinking water.
| null | null |
w14030367_perova
| 0 |
Moreover, the authors present the results properly.
| null | null |
I am pleased to send you major level comments, there are some serious flaws which need to be corrected before publication.
| null | null |
w14030367_perova
| 0 |
Point 14: Please use one style for units such as m3/h or m3h-1 Please revise your paper accordingly since some issue occurs on several spots in the paper.
| null | null |
Author Response Thank you very much for your support and help.
| null | null |
w14030367_perova
| 0 |
Energy Conversion and Management, 235. Panagopoulos, A. (2021).
| null | null |
Results seem to be related to a unique experiment.
| null | null |
w14030367_perova
| 0 |
These 38 PPCPs generally present in waters at trace concentrations, ranging from several ng/L to 39 thousands μg/L [4].
| null | null |
After the gas scrubbing and the hydraulic backwashing, the dissolved oxygen detection of the effluent was carried out, resulting in the above results for dissolved oxygen.
| null | null |
w14030367_perova
| 0 |
Raw water quality parameters of river water (significant value, 0.05).
| null | null |
I can see very well-defined experiments and produced good results.
| null | null |
w14030367_perova
| 0 |
“The combined process with ultrafiltration may be another promising choice, featuring a comparable removing performance as the nanofiltration and low operational cost”.
| null | null |
Environmental Science and Pollution Research, 1-14.
| null | null |
w14030367_perova
| 0 |
So I had to acquire the Florida soil properties information by website.
| null | null |
Journal of Contaminant Hydrology,2015,177-178（June–July）:85-92.
| null | null |
w14081258_makarova
| 0 |
Author Response Dear Editor： Thank you very much for the comments of my manuscript.
| null | null |
At first, the soil was 0.3 mm sieved, but the big particle size was not appropriate for the soil ultrasonic treatment of NP extraction.
| null | null |
w14081258_makarova
| 0 |
Please feel free to contact me if any questions.
| null | null |
Consequently you excluded an important part of the active soil from your study, therefore your resuts are very limited.
| null | null |
w14081258_makarova
| 0 |
I strongly recommend the authors to analysis the biomass of the soil samples R: Indeed, in this study, the analysis of biomass and microorganism of the soil samples is essential.
| null | null |
Indeed, the characteristics of the soil are too limited.
| null | null |
w14081258_makarova
| 0 |
Yours sincerely, Shiyu Wang [email protected] Author Response File: Author Response.docx
| null | null |
Yours sincerely, Shiyu Wang [email protected] Author Response File: Author Response.docx
| null | null |
w14081258_makarova
| 0 |
The main reason is that this experiment was conducted during my being in University of Florida, USA as a visiting scholar.
| null | null |
Please feel free to contact me if any questions.
| null | null |
w14081258_makarova
| 0 |
The basic physi-chemical parameters of soils should be given.
| null | null |
The irrigation water physi-chemical parameters should be given.
| null | null |
w14081258_makarova
| 0 |
Your careful review of this manuscript is highly appreciated.
| null | null |
(+86)13910796093 March 27 Dear Editor and Reviewers： Thank you very much for the comments of my manuscript.
| null | null |
w14081258_makarova
| 0 |
(+86)13910796093 Apr 2 Dear Editor： Thank you very much for the comments of my manuscript.
| null | null |
The following are the details of the revision and marked red in the “resubmit” version.
| null | null |
w14081258_makarova
| 0 |
I have carefully read the comments and made a revision.
| null | null |
I have carefully read the comments and made a revision.
| null | null |
w14081258_makarova
| 0 |
Ecotoxicology and Environmental Safety 158 (2018) 28–36.
| null | null |
R: It has been given in Supporting Information 2.
| null | null |
w14081258_perova
| 0 |
Yours sincerely, Shiyu Wang [email protected] Author Response File: Author Response.docx
| null | null |
Figure 1 legends of axis need font size larger, please make readable the figures R：Accepted and revised in L204.
| null | null |
w14081258_perova
| 0 |
R: It has been given in Supporting Information 2.
| null | null |
Your careful review of this manuscript is highly appreciated.
| null | null |
w14081258_perova
| 0 |
Actually, the soil samples were 0.25 mm sieved.
| null | null |
Figure 1 should be revised according to kinect model.
| null | null |
w14081258_perova
| 0 |
I strongly recommend the authors to analysis the biomass of the soil samples R: Indeed, in this study, the analysis of biomass and microorganism of the soil samples is essential.
| null | null |
(+86)13910796093 March 27 Dear Editor and Reviewers： Thank you very much for the comments of my manuscript.
| null | null |
w14081258_perova
| 0 |
However, the information I can acquire from the website was limited, which were shown in Supporting Information 2.
| null | null |
Shiyu Wang, Wenyong Wu*, Fei Liu, Shiyang Yin, Zhe Bao, Honglu Liu.
| null | null |
w14081258_perova
| 0 |
However, the information I can acquire from the website was limited, which were shown in Supporting Information 2.
| null | null |
The following are the details of the revision and marked red in the “resubmit” version.
| null | null |
w14081258_perova
| 0 |
The following are the details of the revision and marked red in the “resubmit” version.
| null | null |
All the isomers were revised according to kinect model except some isomers, such as NP2 NP5 and NP11.
| null | null |
w14081258_perova
| 0 |
Sorption and desorption behaviours of 4-nonylphenol on reclaimed water-irrigated soils.
| null | null |
Indeed, the characteristics of the soil are too limited.
| null | null |
w14081258_perova
| 0 |
Then the soil was 0.25mm-sieved, which was suitable for the NP extraction.
| null | null |
Comments I do not understand why soil samples were 0.3 mm sieved.
| null | null |
w14081258_perova
| 0 |
Indeed, the characteristics of the soil are too limited.
| null | null |
But for this study, the degradation was completed within 30 days in both of the two soils.
| null | null |
w14081258_perova
| 0 |
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