silicobio/peleke-phi-4
Text Generation
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Updated
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78
Datasets:
Dataset Viewer
pdb_id
stringlengths 4
4
| h_chain_id
stringclasses 47
values | l_chain_id
stringclasses 47
values | antigen_ids
stringclasses 295
values | h_chain_seq
stringlengths 81
242
| l_chain_seq
stringlengths 70
221
| antigen_seqs
stringlengths 1
3.3k
| antibody_seqs
stringlengths 168
456
| h_chain_fv_seq
stringlengths 76
140
| l_chain_fv_seq
stringlengths 66
116
| antibody_fv_seqs
stringlengths 160
249
| highlighted_epitope_seqs
stringlengths 3
3.33k
| epitope_residues
stringlengths 1
639
⌀ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
8xa4
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C
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D
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A|B
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QLQLQESGPGLVKPSETLSLTCTVSGGSISSNNDYWGWIRQPPGKGLEWIGSIYYSGRTNGNPSLKSRVNISADTSKNQFSLKLNSVTAADTAVYYCARLRLGSLLHRYRAVDPWGQGILVAVS
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EIVLTQSPGTLSLSPGERVTLSCRASQRVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHFDSSLLTFGGGTKVEI
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SCNGLYYQGSCYILHSDYKSFEDAKANCAAESSTLPNKSDVLTTWLIDYVEDTWGSDGNPITKTTSDYQDSDVSQEVRKYFC|SCNGLYYQGSCYILHSDYKSFEDAKANCAAESSTLPNKSDVLTTWLIDYVEDTWGSDGNPITKTTSDYQDSDVSQEVRKYFC
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QLQLQESGPGLVKPSETLSLTCTVSGGSISSNNDYWGWIRQPPGKGLEWIGSIYYSGRTNGNPSLKSRVNISADTSKNQFSLKLNSVTAADTAVYYCARLRLGSLLHRYRAVDPWGQGILVAVS|EIVLTQSPGTLSLSPGERVTLSCRASQRVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHFDSSLLTFGGGTKVEI
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QLQLQESGPGLVKPSETLSLTCTVSGGSISSNNDYWGWIRQPPGKGLEWIGSIYYSGRTNGNPSLKSRVNISADTSKNQFSLKLNSVTAADTAVYYCARLRLGSLLHRYRAVDPWGQGILVAVS
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EIVLTQSPGTLSLSPGERVTLSCRASQRVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHFDSSLLTFGGGTKVEI
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QLQLQESGPGLVKPSETLSLTCTVSGGSISSNNDYWGWIRQPPGKGLEWIGSIYYSGRTNGNPSLKSRVNISADTSKNQFSLKLNSVTAADTAVYYCARLRLGSLLHRYRAVDPWGQGILVAVS|EIVLTQSPGTLSLSPGERVTLSCRASQRVSSTYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQHFDSSLLTFGGGTKVEI
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SCNGLYYQGSCYI[L]HSD[Y]KSFEDAKANCAAESSTLPNKSDVLTTWLI[D][Y]V[E][D][T]WGSDGNPITKTTSD[Y]QDS[D]VS[Q][E]V[R][K]Y[F]C|SCNGLYYQGSCYI[L]H[S][D][Y]KSFEDAKANCAAESSTLPNKSDVLTTWLI[D][Y]VE[D][T]WGSDGNPITKTTSD[Y]QDSDVS[Q][E][V][R][K]Y[F]C
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A:ARG 176|A:ASP 146|A:ASP 150|A:ASP 170|A:GLN 173|A:GLU 149|A:GLU 174|A:LEU 112|A:LYS 177|A:PHE 179|A:THR 151|A:TYR 116|A:TYR 147|A:TYR 166|B:ARG 176|B:ASP 115|B:ASP 146|B:ASP 150|B:GLN 173|B:GLU 174|B:LEU 112|B:LYS 177|B:PHE 179|B:SER 114|B:THR 151|B:TYR 116|B:TYR 147|B:TYR 166|B:VAL 175
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9cph
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H
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L
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A
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EVQLVESGGGLVQPGGSLRLSCAASGFNLSSSSIHWVRQAPGKGLEWVASIYSYYGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCAREYHSYWSYSWWPRVGLDYWGQGTLVTVSSASTKGPSVFPLAPAAAAATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
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AQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQASLTALLTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTIIELYRQSLEIISRYLREQATGAADTAPMGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESAIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFF
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EVQLVESGGGLVQPGGSLRLSCAASGFNLSSSSIHWVRQAPGKGLEWVASIYSYYGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCAREYHSYWSYSWWPRVGLDYWGQGTLVTVSSASTKGPSVFPLAPAAAAATAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC|AQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQASLTALLTFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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EVQLVESGGGLVQPGGSLRLSCAASGFNLSSSSIHWVRQAPGKGLEWVASIYSYYGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCAREYHSYWSYSWWPRVGLDYWGQGTLVTVSS
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AQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQASLTALLTFGQGTKVEIK
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EVQLVESGGGLVQPGGSLRLSCAASGFNLSSSSIHWVRQAPGKGLEWVASIYSYYGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCAREYHSYWSYSWWPRVGLDYWGQGTLVTVSS|AQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQASLTALLTFGQGTKVEIK
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KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKL[Y][P][F]TW[D][A]VRYN[G]KLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFK[Y]EN[G][K][Y]DIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPF[V]GVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSY[E][E]EL[A]KDPR[I][A]AT[M][E]N[A][Q][K][G][E][I]M[P]NIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTIIELYRQSLEIISRYLREQATGAADTAPMGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESAIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFF
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A:ALA 1116|A:ALA 1122|A:ALA 1128|A:ALA 900|A:ASP 899|A:GLN 1129|A:GLU 1112|A:GLU 1113|A:GLU 1126|A:GLU 1132|A:GLY 1131|A:GLY 905|A:GLY 978|A:ILE 1121|A:ILE 1133|A:LYS 1130|A:LYS 979|A:MET 1125|A:PHE 896|A:PRO 1135|A:PRO 895|A:TYR 894|A:TYR 975|A:TYR 980|A:VAL 1063
|
9d7i
|
H
|
G
|
E
|
VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVYFPEPVTVSWVHTFPAVLQSSGLYSLSSVV
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSATLVCLISDFYPGAVTVAWKASPVKAGVETTTPSKQSNNKYAASSYLSLTPQWSHRSYSCQVTHEGSTVEKTAP
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVYFPEPVTVSWVHTFPAVLQSSGLYSLSSVV|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSATLVCLISDFYPGAVTVAWKASPVKAGVETTTPSKQSNNKYAASSYLSLTPQWSHRSYSCQVTHEGSTVEKTAP
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQI[N]NKEYRL[I]NC[N][T]SACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITN[N]AKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSS[G][G][D][L]E[V][T]THSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIIN[M]WQ[R][I][G]QCMYAPPIQGVIRCVSNITGLILT[R]D[G][G][S][T][N]STTETFR[P][G][G]GDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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E:ARG 429|E:ARG 469|E:ASN 177|E:ASN 197|E:ASN 280|E:ASN 425|E:ASP 368|E:ASP 457|E:GLN 428|E:GLU 370|E:GLY 366|E:GLY 367|E:GLY 458|E:GLY 459|E:GLY 471|E:ILE 194|E:ILE 430|E:PRO 470|E:SER 365|E:SER 460|E:THR 198|E:THR 455|E:THR 461|E:VAL 371
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9d7i
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J
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I
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C
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVYFPEPVTVSWVHTFPAVLQSSGLYSLSSVV
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSATLVCLISDFYPGAVTVAWKASPVKAGVETTTPSKQSNNKYAASSYLSLTPQWSHRSYSCQVTHEGSTVEKTAP
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVYFPEPVTVSWVHTFPAVLQSSGLYSLSSVV|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSATLVCLISDFYPGAVTVAWKASPVKAGVETTTPSKQSNNKYAASSYLSLTPQWSHRSYSCQVTHEGSTVEKTAP
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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VQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSKNQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRL[I]NC[N][T]SACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITN[N]AKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANS[S][G][G][D][L][E][V][T]THSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIK[Q]IIN[M]WQ[R]I[G]QCMYAPPIQGVIRCVSNITGLILT[R]D[G][G][S][T][N]STTETFR[P][G][G]G[D]MRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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C:ARG 469|C:ASN 197|C:ASN 280|C:ASN 425|C:ASP 368|C:ASP 457|C:GLN 428|C:GLU 370|C:GLY 366|C:GLY 367|C:GLY 458|C:GLY 459|C:GLY 471|C:GLY 473|C:ILE 194|C:ILE 430|C:LEU 369|C:LYS 421|C:PRO 470|C:SER 364|C:SER 365|C:SER 460|C:THR 198|C:THR 455|C:THR 461|C:VAL 371
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9d7o
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H
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G
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E
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVFPLGCLVKDYFPEPVTVSWTFPAVLQSSGLYSLSSVVCNVNHKPSNT
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSLVCLISDFYPGAVTVAWGVETTTPSKQSNNKYAASSYLSCQVTHEGSTV
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINESNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVFPLGCLVKDYFPEPVTVSWTFPAVLQSSGLYSLSSVVCNVNHKPSNT|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSLVCLISDFYPGAVTVAWGVETTTPSKQSNNKYAASSYLSCQVTHEGSTV
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQIN[E]SNKEYRL[I]NC[N]TSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITN[N]AKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANS[S][G][G][D][L][E]V[T]THSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIIN[M]WQ[R][I][G]QCMYAPPIQGVIRCVSNITGLILT[R]D[G][G][S][T][N]STTETFR[P][G][G]G[D]MRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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E:ARG 429|E:ARG 469|E:ASN 197|E:ASN 280|E:ASN 425|E:ASP 368|E:ASP 457|E:GLN 428|E:GLU 178|E:GLY 366|E:GLY 367|E:GLY 458|E:GLY 459|E:GLY 471|E:GLY 473|E:ILE 194|E:ILE 430|E:LEU 369|E:PRO 470|E:SER 364|E:SER 365|E:SER 460|E:THR 455|E:THR 461|E:VAL 371
|
9d7p
|
H
|
G
|
E
|
QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVFPLGCLVKDYFPEPVTVSWTFPAVLQSSGLYSLSSVVCNVNHKPSNT
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSLVCLISDFYPGAVTVAWGVETTTPSKQSNNKYAASSYLSCQVTHEGSTV
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LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINESNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVFPLGCLVKDYFPEPVTVSWTFPAVLQSSGLYSLSSVVCNVNHKPSNT|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPSLVCLISDFYPGAVTVAWGVETTTPSKQSNNKYAASSYLSCQVTHEGSTV
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA
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YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
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QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
|
LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQIN[E]SNKEYRL[I]NC[N][T]SACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITN[N]AKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANS[S][G][G][D][L][E][V][T]THSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIIN[M]WQ[R][I][G]QCMYAPPIQGVIRCVSNITGLILT[R]D[G][G][S][T][N]STTETFR[P][G][G]G[D]MRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
E:ARG 429|E:ARG 469|E:ASN 197|E:ASN 280|E:ASN 425|E:ASP 368|E:ASP 457|E:GLN 428|E:GLU 178|E:GLU 370|E:GLY 366|E:GLY 367|E:GLY 458|E:GLY 459|E:GLY 471|E:GLY 473|E:ILE 194|E:ILE 430|E:LEU 369|E:PRO 470|E:SER 364|E:SER 365|E:SER 460|E:THR 198|E:THR 455|E:THR 461|E:VAL 371
|
9d7p
|
J
|
I
|
C
|
QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVFPLLGCLVKDYFPEPVTVTFPAVLQSSGLYSLSSVV
|
YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPATLVCLISDFYPGAVTVAWVETTTPSKQSNNKYAASSYLCQVTHEGSTVEK
|
LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNSNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTAASTKGPSVFPLLGCLVKDYFPEPVTVTFPAVLQSSGLYSLSSVV|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVGQPKANPTVTLFPPATLVCLISDFYPGAVTVAWVETTTPSKQSNNKYAASSYLCQVTHEGSTVEK
|
QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA
|
YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
|
QVQLQESGPGVVKSSETLSLTCTVSGGSMGGTYWSWLRLSPGKGLEWIGYIFHTGETNYSPSLKGRVSISVDTSEDQFSLRLTAADTAVYFCASLPRGQLRNWGRGSLVSVTA|YELTQPPSVSVSPGQTATITCSGASTNVCWYQVKPGQSPEVVIFENYKRPSGIPDRFSGSKSGSTATLTIRGTQAIDEADYYCQVWDSFSFVFGSGTQVTVG
|
LWVTVYYGVPVWKDAETTLFCASDNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRL[I]NCN[T]SACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITN[N]AKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSS[G][G][D][L][E][V][T]THSFNCGGEFFYCNTSGLFNSTWISNSNDSITLPCRIKQIIN[M]WQ[R]I[G]QCMYAPPIQGVIRCVSNITGLILT[R]D[G][G][S][T][N]STTETFR[P][G][G]G[D]MRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
C:ARG 469|C:ASN 280|C:ASN 425|C:ASP 368|C:ASP 457|C:GLN 428|C:GLU 370|C:GLY 366|C:GLY 367|C:GLY 458|C:GLY 459|C:GLY 471|C:GLY 473|C:ILE 194|C:ILE 430|C:LEU 369|C:PRO 470|C:SER 365|C:SER 460|C:THR 198|C:THR 455|C:THR 461|C:VAL 371
|
9hb3
|
H
|
L
|
R
|
EVQLVESGGGLVQPGGSLRLSCAASGFNVVDFSLHWVRQAPGKGLEWVAYISSSSGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARWGYWPGEPWWKAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYLYYSLVTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
|
LLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPNRPVLVAWAFSLLLSLPQLFIFAQTDCWACFWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHAAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLRARSTL
|
EVQLVESGGGLVQPGGSLRLSCAASGFNVVDFSLHWVRQAPGKGLEWVAYISSSSGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARWGYWPGEPWWKAFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK|DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYLYYSLVTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
|
EVQLVESGGGLVQPGGSLRLSCAASGFNVVDFSLHWVRQAPGKGLEWVAYISSSSGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARWGYWPGEPWWKAFDYWGQGTLVTVSS
|
DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYLYYSLVTFGQGTKVEIK
|
EVQLVESGGGLVQPGGSLRLSCAASGFNVVDFSLHWVRQAPGKGLEWVAYISSSSGSTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARWGYWPGEPWWKAFDYWGQGTLVTVSS|DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYLYYSLVTFGQGTKVEIK
|
LLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPNRPVLVAWAFSLLLSLPQLFIFAQTDCWACFWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHAAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRARRQLADLEDNWETLNDNLKVIEKADNAAQV[K]DAL[T]KM[R][A]AA[L][D]AQ[K]ATPMKDFRHGF[D]IL[V][G]QI[D]DA[L][K]LA[N][E]GKVKEAQAAAEQLKTTRNAYIQKYLRARSTL
|
R:ALA 539|R:ARG 538|R:ASN 584|R:ASP 543|R:ASP 570|R:ASP 577|R:GLU 585|R:GLY 574|R:LEU 542|R:LEU 580|R:LYS 531|R:LYS 546|R:LYS 581|R:THR 535|R:VAL 573
|
9iut
|
A
|
B
|
C
|
GREVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCSGSDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIE
|
RDVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIKFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQCKRQPILDAIEAKGTLLG
|
MPIWKFPD
|
GREVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCSGSDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIE|RDVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIKFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQCKRQPILDAIEAKGTLLG
|
EVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCS
|
DVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIK
|
EVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCS|DVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIK
|
[M][P][I][W][K][F][P][D]
|
C:ASP 618|C:ILE 613|C:LYS 615|C:MET 611|C:PHE 616|C:PRO 612|C:PRO 617|C:TRP 614
|
9iut
|
D
|
E
|
F
|
REVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCSGSDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIE
|
DVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQCKRQPILDAIEAK
|
MPIWKFPD
|
REVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCSGSDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIE|DVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQCKRQPILDAIEAK
|
EVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCS
|
DVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIY
|
EVQLVESGGGLVQPGGSLKLSCAASGFTFSNYGMSWVRQTPDRRLELVATINNGGGTYYPDSVKGRFTISRDNAKNTLYLQMKSEDTAMYYCTSPGLLWDAWGAGTTVTVCS|DVVMTQTPLTLSVSIGQPASISCKSSQSLLTYLNWLLQRPGQSPKRLIYLVSKLDSGAPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPQTFGGGTKLEIY
|
[M][P][I][W][K][F][P][D]
|
F:ASP 618|F:ILE 613|F:LYS 615|F:MET 611|F:PHE 616|F:PRO 612|F:PRO 617|F:TRP 614
|
9ml4
|
H
|
L
|
A
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS
|
DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS|DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS
|
DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS|DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y]N[S][A]S[F][S]T[F][K][C][Y][G][V][S][P]TKLNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G][Q]TGKIADYNYKLP[D][D]FTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
A:ALA 372|A:ALA 411|A:ARG 408|A:ASP 427|A:ASP 428|A:CYS 379|A:GLN 414|A:GLY 381|A:GLY 413|A:LYS 378|A:PHE 374|A:PHE 377|A:PRO 384|A:PRO 412|A:SER 371|A:SER 375|A:SER 383|A:TYR 369|A:TYR 380|A:VAL 382
|
9ml4
|
M
|
N
|
B
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS
|
DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS|DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS
|
DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS|DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y]N[S][A]S[F][S]T[F][K][C][Y][G][V][S][P]TKLNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G][Q]TGKIADYNYKLP[D][D]FTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
B:ALA 372|B:ALA 411|B:ARG 408|B:ASP 427|B:ASP 428|B:CYS 379|B:GLN 414|B:GLY 381|B:GLY 413|B:LYS 378|B:PHE 374|B:PHE 377|B:PRO 384|B:PRO 412|B:SER 371|B:SER 375|B:SER 383|B:TYR 369|B:TYR 380|B:VAL 382
|
9ml4
|
P
|
Q
|
C
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS
|
DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS|DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS
|
DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
ESLEESGGGLVQPGASLTLTCKASGFSFSSGYYMWVRQAPGKGLEWIACTSSSQYTIYANWAKGRSTISKTSSTTVTLQMTTAADTATYFCARGPSTYYDLWGPGTLVTVSS|DVVMTQTPASVSEPVGGTVTTKCQASQNIFNNLAWYQQKPGQPPKLLISDASNLASGVSSRFTGSGSGTEYTLTIGDLECADGATYYCQSTSYGNAAFGGGTEVVV
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y]N[S][A]S[F][S]T[F][K][C][Y][G][V][S][P]TKLNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G][Q]TGKIADYNYKLP[D][D]FTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
C:ALA 372|C:ALA 411|C:ARG 408|C:ASP 427|C:ASP 428|C:CYS 379|C:GLN 414|C:GLY 381|C:GLY 413|C:LYS 378|C:PHE 374|C:PHE 377|C:PRO 384|C:PRO 412|C:SER 371|C:SER 375|C:SER 383|C:TYR 369|C:TYR 380|C:VAL 382
|
9ml5
|
H
|
L
|
A
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVI[R][G][D][E][V][R]QIAPGQT[G][K]IADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYL[Y]R[L][F]RKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGF[Q]P[T][N][G][V][G][Y][Q]P[Y]RVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
A:ARG 403|A:ARG 408|A:ASN 501|A:ASP 405|A:GLN 498|A:GLN 506|A:GLU 406|A:GLY 404|A:GLY 416|A:GLY 502|A:GLY 504|A:LEU 455|A:LYS 417|A:PHE 456|A:THR 500|A:TYR 453|A:TYR 505|A:TYR 508|A:VAL 407|A:VAL 503
|
9ml5
|
M
|
N
|
B
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
QEQLEESGGGLVKPEGSLTLTCTASGFSFSSSYWIWVRQAPGKGLEWIGCIYGDGSTYYATWAKGRFTISKASSTTVTLQMTTAADTATYFCTREGGWYDNLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTINCQASESISNYLSWYQQKPGQRPKLLIYYASTLASGVSSRFKGSRSGTEYTLTISDLECADAATYYCQSAADSIHAFGGGTEVLVK
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIR[G][D][E][V]RQIAPGQ[T][G][K]IADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYL[Y]R[L]FRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGF[Q]P[T][N][G][V][G][Y][Q]P[Y]RVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
B:ASN 501|B:ASP 405|B:GLN 498|B:GLN 506|B:GLU 406|B:GLY 404|B:GLY 416|B:GLY 502|B:GLY 504|B:LEU 455|B:LYS 417|B:THR 415|B:THR 500|B:TYR 453|B:TYR 505|B:TYR 508|B:VAL 407|B:VAL 503
|
9ml6
|
H
|
L
|
A
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKR
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKR
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y][N]SASFST[F][K][C][Y][G][V][S][P][T]KLNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G][Q]TGKIADYNYKLP[D][D][F]TGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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A:ALA 411|A:ARG 408|A:ASN 370|A:ASP 427|A:ASP 428|A:CYS 379|A:GLN 414|A:GLY 381|A:GLY 413|A:LYS 378|A:PHE 377|A:PHE 429|A:PRO 384|A:PRO 412|A:SER 383|A:THR 385|A:TYR 369|A:TYR 380|A:VAL 382
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9ml6
|
M
|
N
|
B
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
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DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKR
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AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKR
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
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DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
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AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y][N]SASFST[F][K][C][Y][G][V][S][P][T]KLNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G][Q]TGKIADYNYKLP[D][D][F][T]GCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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B:ALA 411|B:ARG 408|B:ASN 370|B:ASP 427|B:ASP 428|B:CYS 379|B:GLN 414|B:GLY 381|B:GLY 413|B:LYS 378|B:PHE 377|B:PHE 429|B:PRO 384|B:PRO 412|B:SER 383|B:THR 385|B:THR 430|B:TYR 369|B:TYR 380|B:VAL 382
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9ml6
|
P
|
Q
|
C
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
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DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKR
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AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKR
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
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DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
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QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
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AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y][N]SASFST[F][K][C][Y][G][V][S][P][T][K]LNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G]Q[T]GKIADYNYKLP[D][D][F][T]GCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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C:ALA 411|C:ARG 408|C:ASN 370|C:ASP 427|C:ASP 428|C:CYS 379|C:GLY 381|C:GLY 413|C:LYS 378|C:LYS 386|C:PHE 377|C:PHE 429|C:PRO 384|C:PRO 412|C:SER 383|C:THR 385|C:THR 415|C:THR 430|C:TYR 369|C:TYR 380|C:VAL 382
|
9ml7
|
H
|
L
|
A|C
|
QSLEESGGDLVKPGASLTLTCTASGFTFSRYYMSWVRQAPGKGLQWIGCIDTIDTTYYASWAKGRFTISKTSSTTVTLQMTSAADTATYFCARGMVVVDLWGPGTLVTVSS
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QVLTQTPSSVSAAVGGTVTINCQSSQVNNNDLAWYQQKPGQPPKLLIYFVSTLPSGVSSRFKGSGSGTQFTLTISGVQCDDAATYYCQGGFGCNTAFGGGTEVVVKR
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS|AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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QSLEESGGDLVKPGASLTLTCTASGFTFSRYYMSWVRQAPGKGLQWIGCIDTIDTTYYASWAKGRFTISKTSSTTVTLQMTSAADTATYFCARGMVVVDLWGPGTLVTVSS|QVLTQTPSSVSAAVGGTVTINCQSSQVNNNDLAWYQQKPGQPPKLLIYFVSTLPSGVSSRFKGSGSGTQFTLTISGVQCDDAATYYCQGGFGCNTAFGGGTEVVVKR
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QSLEESGGDLVKPGASLTLTCTASGFTFSRYYMSWVRQAPGKGLQWIGCIDTIDTTYYASWAKGRFTISKTSSTTVTLQMTSAADTATYFCARGMVVVDLWGPGTLVTVSS
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QVLTQTPSSVSAAVGGTVTINCQSSQVNNNDLAWYQQKPGQPPKLLIYFVSTLPSGVSSRFKGSGSGTQFTLTISGVQCDDAATYYCQGGFGCNTAFGGGTEVVVK
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QSLEESGGDLVKPGASLTLTCTASGFTFSRYYMSWVRQAPGKGLQWIGCIDTIDTTYYASWAKGRFTISKTSSTTVTLQMTSAADTATYFCARGMVVVDLWGPGTLVTVSS|QVLTQTPSSVSAAVGGTVTINCQSSQVNNNDLAWYQQKPGQPPKLLIYFVSTLPSGVSSRFKGSGSGTQFTLTISGVQCDDAATYYCQGGFGCNTAFGGGTEVVVK
|
AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNS[N][N]LDS[K][V]GGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGF[Q][P][T][N][G][V][G][Y]QPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS|AYTNSFTRGVYYPDKVFRSSVLHSTQDLFLPFFSNVTWFHAIHRFDNPVLPFNDGVYFASTEKSNIIRGWIFGTTLDSKTQSLLIVNNATNVVIKVCEFQFCNDPFLGVNCTFEYVSFKNLREFVFKNIDGYFKIYSKHTPINLVRDLPQGFSALEPLVDLPIGINITRFQTLLALHAAYYVGYLQPRTFLLKYNENGTITDAVDCALDPLSETKCTLKSFTVEKGIYQTSNFRVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLP[D]DFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNFNFNGLTGTGVLTESNKKFLPFQQFGRDIADTTDAVRDPQTLEILDITPCSFGGVSVITPGTNTSNQVAVLYQDVNCTEVPVYSTGSNVFQTRAGCLIGAEHVNNSYECDIPIGAGICASYQTSQSIIAYTMSLGAENSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSPIEDLLFNKVTKFNGLTVLPPLLTDEMIAQYTSALLAGTITSGWTFGAGPALQIPFPMQMAYRFNGIGVTQNVLYENQKLIANQFNSAIGKIQDSLSSTPSALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDPPEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGIVNNTVYDPLQPELDS
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A:ASN 439|A:ASN 440|A:ASN 501|A:GLN 498|A:GLY 502|A:GLY 504|A:LYS 444|A:PRO 499|A:THR 500|A:TYR 505|A:VAL 445|A:VAL 503|C:ASP 427
|
9ml8
|
E
|
F
|
B
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
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AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
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TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
TNLCPFGEVFNATRFASVYA[W]N[R]K[R]IS[N]CVADYSVLYNSASFSTFKCYGVSPTKLNDLCFT[N]V[Y]ADSFVIRGDEVRQIAPGQTGKIADYNYKLPD[D]FTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNL[K][P][F][E][R][D][I][S]T[E]IYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVL[S]F[E]L[L][H][A][P]ATVCGPK
|
B:ALA 520|B:ARG 355|B:ARG 357|B:ARG 466|B:ASN 360|B:ASN 394|B:ASP 428|B:ASP 467|B:GLU 465|B:GLU 471|B:GLU 516|B:HIS 519|B:ILE 468|B:LEU 518|B:LYS 462|B:PHE 464|B:PRO 463|B:PRO 521|B:SER 469|B:SER 514|B:TRP 353|B:TYR 396
|
9ml8
|
H
|
L
|
A
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
TNLCPFGEVFNATRFASVYA[W]N[R]K[R]I[S][N]CVADYSVLYNSASFSTFKCYGVSPTKLNDLCFT[N]V[Y]ADSFVIRGDEVRQIAPGQTGKIADYNYKLPD[D]F[T]GCVIAWNSNNLDSKVGGNYNYLYRLFRKSNL[K][P][F][E][R][D][I][S]T[E]IYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVL[S]F[E]L[L][H][A][P]ATVCGPK
|
A:ALA 520|A:ARG 355|A:ARG 357|A:ARG 466|A:ASN 360|A:ASN 394|A:ASP 428|A:ASP 467|A:GLU 465|A:GLU 471|A:GLU 516|A:HIS 519|A:ILE 468|A:LEU 518|A:LYS 462|A:PHE 464|A:PRO 463|A:PRO 521|A:SER 359|A:SER 469|A:SER 514|A:THR 430|A:TRP 353|A:TYR 396
|
9ml8
|
M
|
N
|
C
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
TNLCPFGEVFNATRFASVYA[W]N[R]K[R]IS[N]CVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNV[Y]ADSFVIRGDEVRQIAPGQTGKIADYNYKLPD[D]FTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNL[K][P][F][E][R][D]I[S]T[E]IYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVL[S]F[E]L[L][H][A][P]ATVCGPK
|
C:ALA 520|C:ARG 355|C:ARG 357|C:ARG 466|C:ASN 360|C:ASP 428|C:ASP 467|C:GLU 465|C:GLU 471|C:GLU 516|C:HIS 519|C:LEU 518|C:LYS 462|C:PHE 464|C:PRO 463|C:PRO 521|C:SER 469|C:SER 514|C:TRP 353|C:TYR 396
|
9ml8
|
P
|
Q
|
D
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSSGQPKAPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS
|
AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
QSLEESGGDLVKPGASLTLTCTASGFSFSGSYYMWVRQAPGKGLEWIACIYSSDNAYYASWAKGRFTISKTSSTTVTLQMTAADTATYFCARGVYFYAVLWGPGTLVTVSS|AQVLTQTPSSVSAAVGGTVSISCQSSQVYSNYLSWYQQKPGQPPKLLIYDASTLASGVPSRFKGSGSGTQFTLTISGVQCDDAATYYCQGSYYSSYPFGGGTEVVVK
|
TNLCPFGEVFNATRFASVYA[W]N[R]K[R]IS[N]CVADYSVLYNSASFSTFKCYGVSPTKLNDLCFT[N]V[Y]ADSFVIRGDEVRQIAPGQTGKIADYNYKLPD[D]FTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNL[K][P][F][E][R][D]I[S]T[E]IYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVL[S][F][E]L[L][H][A][P]ATVCGPK
|
D:ALA 520|D:ARG 355|D:ARG 357|D:ARG 466|D:ASN 360|D:ASN 394|D:ASP 428|D:ASP 467|D:GLU 465|D:GLU 471|D:GLU 516|D:HIS 519|D:LEU 518|D:LYS 462|D:PHE 464|D:PHE 515|D:PRO 463|D:PRO 521|D:SER 469|D:SER 514|D:TRP 353|D:TYR 396
|
9ml9
|
H
|
L
|
A
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSSGQPKAPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
|
TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSSGQPKAPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS
|
DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
|
QSLEESGGDLVKPGTSLTLTCTASGFSFSHNYVMWVRQAPGKGLECVACIYGFGDTYYASWAKGRITISKTSSTTVTLQMTTAADTATYFCARALGYYIKLWGPGTLVTVSS|DIVMTQTPASVEAAVGGTVTIKCQASQSISKYLAWYQQKPGQPPKLLIFEASTLESGVPSRFKGRGSGTEFTLTISDLECADAATYYCQGYYYSSYVFGGGTEVVVK
|
TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVL[Y][N]SASFST[F][K][C][Y][G][V][S][P][T]KLNDLCFTNVYADSFVIRGDEV[R]QI[A][P][G]QTGKIADYNYKLP[D][D][F][T]GCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPK
|
A:ALA 411|A:ARG 408|A:ASN 370|A:ASP 427|A:ASP 428|A:CYS 379|A:GLY 381|A:GLY 413|A:LYS 378|A:PHE 377|A:PHE 429|A:PRO 384|A:PRO 412|A:SER 383|A:THR 385|A:THR 430|A:TYR 369|A:TYR 380|A:VAL 382
|
8r4n
|
H
|
L
|
N
|
QVQLTESGPGLVKPSQTLSLTCTVSGLSLSRNTAGWVRQAPGKGLEWVGDISGDGSEYYNPVLKPRVSITKDTSKSQLYLTLTSEDTAVYYCTGSGDTYYRYWGQGILVTVSSASTTAPKVFPLASHGSTVALGCLVSSYFPEPVTVSWNSGALTSGVHTFPSVLQSSGLYSLSSMVTVPASSLKSQTYICNVAHPASSTKVDKKI
|
QSVTQPASVSGTLGQTVTISCSGSKDTPTYVGWFQQIPGTAPKTLIYGDNRRASGVPDRFSGSVSGNTATLTISGVQAEDEAVYWCGSWDVNSELFGGGTHLTIAGPTSAPSVSLFPPSSEELSANKATVVCLISDFSPSGLEVIWKVNDQTTRPSKQSNGKYAASSYLTRTSTEWKSYSSVSCQVKHQGKTVEKKVSPSE
|
RICYNHQSTTRATTKSCEENSCYKKYWRDHRGTIIERGCGCPKVKPGVGIHCCQSDKCNY
|
QVQLTESGPGLVKPSQTLSLTCTVSGLSLSRNTAGWVRQAPGKGLEWVGDISGDGSEYYNPVLKPRVSITKDTSKSQLYLTLTSEDTAVYYCTGSGDTYYRYWGQGILVTVSSASTTAPKVFPLASHGSTVALGCLVSSYFPEPVTVSWNSGALTSGVHTFPSVLQSSGLYSLSSMVTVPASSLKSQTYICNVAHPASSTKVDKKI|QSVTQPASVSGTLGQTVTISCSGSKDTPTYVGWFQQIPGTAPKTLIYGDNRRASGVPDRFSGSVSGNTATLTISGVQAEDEAVYWCGSWDVNSELFGGGTHLTIAGPTSAPSVSLFPPSSEELSANKATVVCLISDFSPSGLEVIWKVNDQTTRPSKQSNGKYAASSYLTRTSTEWKSYSSVSCQVKHQGKTVEKKVSPSE
|
QVQLTESGPGLVKPSQTLSLTCTVSGLSLSRNTAGWVRQAPGKGLEWVGDISGDGSEYYNPVLKPRVSITKDTSKSQLYLTLTSEDTAVYYCTGSGDTYYRYWGQGILVTVSS
|
SVTQPASVSGTLGQTVTISCSGSKDTPTYVGWFQQIPGTAPKTLIYGDNRRASGVPDRFSGSVSGNTATLTISGVQAEDEAVYWCGSWDVNSELFGGGTHLTIA
|
QVQLTESGPGLVKPSQTLSLTCTVSGLSLSRNTAGWVRQAPGKGLEWVGDISGDGSEYYNPVLKPRVSITKDTSKSQLYLTLTSEDTAVYYCTGSGDTYYRYWGQGILVTVSS|SVTQPASVSGTLGQTVTISCSGSKDTPTYVGWFQQIPGTAPKTLIYGDNRRASGVPDRFSGSVSGNTATLTISGVQAEDEAVYWCGSWDVNSELFGGGTHLTIA
|
RICYNHQSTTRATTKSCEENSCYK[K]Y[W][R][D][H]RGTII[E]RGCGCP[K][V][K][P][G][V]GIHCCQSDKCNY
|
N:ARG 28|N:ASP 29|N:GLU 36|N:GLY 47|N:HIS 30|N:LYS 25|N:LYS 43|N:LYS 45|N:PRO 46|N:TRP 27|N:VAL 44|N:VAL 48
|
8vte
|
B
|
A
|
E
|
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
|
GTIETTGNISAEKGGSIILQCHLTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEV
|
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK|DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
|
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSS
|
DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIK
|
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSS|DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIK
|
GTIETTGNISAEKGGSIILQCHLTAQV[T][Q]V[N]W[E]QQ[D][Q][L]L[A][I]C[N]AD[L]GW[H][I][S][P][S]F[K]DRVAPGPGLGLTLQSLTVNDTGEYFC[I]Y[H]TYPDGTYTGRIFLEV
|
E:ALA 67|E:ASN 58|E:ASN 70|E:ASP 63|E:GLN 56|E:GLN 64|E:GLU 60|E:HIS 111|E:HIS 76|E:ILE 109|E:ILE 68|E:ILE 77|E:LEU 65|E:LEU 73|E:LYS 82|E:PRO 79|E:SER 78|E:SER 80|E:THR 55
|
8vte
|
D
|
C
|
F
|
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
|
DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG
|
MMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLE
|
EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK|DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG
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EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSS
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DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIK
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EVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGKTYYRFKWYSDYAVSVKGRITINPDTSKNQFSLQLNSVTPEDTAVFYCTRESTTYDLLAGPFDYWGQGTLVTVSS|DIVMTQSPDSLAVSLGERATINCKSSQTVLYSSNNKKYLAWYQQKPGQPPNLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPFTFGPGTKVEIK
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MMTGTIETTGNISAEKGGSIILQCHLSSTTAQV[T][Q]V[N]W[E]QQ[D][Q][L]L[A][I]CNAD[L]GW[H][I][S][P][S]F[K][D]RVAPGPGLGLTLQSLTVNDTGEYFCIY[H]TYPDGTYTGRIFLEVLE
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F:ALA 67|F:ASN 58|F:ASP 63|F:ASP 83|F:GLN 56|F:GLN 64|F:GLU 60|F:HIS 111|F:HIS 76|F:ILE 68|F:ILE 77|F:LEU 65|F:LEU 73|F:LYS 82|F:PRO 79|F:SER 78|F:SER 80|F:THR 55
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8zeu
|
H
|
L
|
C
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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YDFTNCDFEKIKAAYLSTISKDLITYMSVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSNKCLEQVSQLQGLWRRFNRPL
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSS
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSS|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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YDFTNCDFEKIK[A][A]YL[S][T]IS[K][D]LI[T]YMSVSCSNRPHCLTEIQSLTFNPTAGCASLA[K]E[M]FA[M][K]T[K][A][A]L[A][I][W]CPGY[S]NKCLEQVSQLQGLWRRFNRPL
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C:ALA 104|C:ALA 105|C:ALA 107|C:ALA 41|C:ALA 42|C:ASP 50|C:ILE 108|C:LYS 101|C:LYS 103|C:LYS 49|C:LYS 95|C:MET 100|C:MET 97|C:SER 114|C:SER 45|C:THR 46|C:THR 53|C:TRP 109
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8zeu
|
A
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B
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C
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKTVEP
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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YDFTNCDFEKIKAAYLSTISKDLITYMSVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSNKCLEQVSQLQGLWRRFNRPL
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKTVEP|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSS
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSS|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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YDFTNCDFEKIK[A][A]YL[S][T]IS[K][D]LI[T]YMSVSCSNRPHCLTEIQSLTFNPTAGCASLA[K]E[M]FA[M][K]T[K][A][A]L[A][I][W]CPGY[S]NKCLEQVSQLQGLWRRFNRPL
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C:ALA 104|C:ALA 105|C:ALA 107|C:ALA 41|C:ALA 42|C:ASP 50|C:ILE 108|C:LYS 101|C:LYS 103|C:LYS 49|C:LYS 95|C:MET 100|C:MET 97|C:SER 114|C:SER 45|C:THR 46|C:THR 53|C:TRP 109
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8zeu
|
D
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E
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G
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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YDFTNCDFEKIKAAYLSTISKDLITYMSVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSNKCLEQVSQLQGLWRRFNRPL
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSS
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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QVQLVQSGAEVKKPGASVKVSCKASGYAFSNYWMNWVRQAPGQGLEWMGQIFPGDSDTDYDQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARAGYYRGYYAMDYWGQGTTVTVSS|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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YDFTNCDF[E]KI[K][A]AY[L]STISKDLITYMSV[S]CSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSNKCLEQVSQLQGLW[R][R]F[N][R][P][L]
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G:ALA 41|G:ARG 149|G:ARG 150|G:ARG 153|G:ASN 152|G:GLU 37|G:LEU 155|G:LEU 44|G:LYS 40|G:PRO 154|G:SER 68
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8zeu
|
I
|
F
|
G
|
QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKTVEP
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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YDFTNCDFEKIKAAYLSTISKDLITYMSVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSNKCLEQVSQLQGLWRRFNRPL
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKTVEP|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSS
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EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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QVTLKESGPVLVKPTETLTLTCTVSGFSLSSYDISWIRQPPGKALEWLGVIWSEGGTSYSTSLKSRLTISKDTSKSQVVLTMTNMDPVDTATYYCARDSDDGYLNWGQGTLVTVSS|EIVMTQSPATLSVSPGERATLSCSVSSSISSSNLHWYQQKPGQAPRPWIYGTSNLASGIPARFSGSGSGTEFTLTISSVQAEDFAVYYCQQWSSYPLTFGQGTKLEIK
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YDFTNCDF[E]KI[K][A]AY[L]STISKDLITYMSV[S]CSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSNKCLEQVSQLQGLW[R][R]F[N][R][P][L]
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G:ALA 41|G:ARG 149|G:ARG 150|G:ARG 153|G:ASN 152|G:GLU 37|G:LEU 155|G:LEU 44|G:LYS 40|G:PRO 154|G:SER 68
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9cb1
|
A
|
D
|
G
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV
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DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIKR
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LKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTCSFVLGAIACGVATAAAVTAGVAIAKCIRLESEVTAIKNCLKKTNECVSTLGCGVRVLATAVRELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISKDLMTDAELARAISNMPTSAGQIKLMLENRCMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPCEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSCGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPQDQFNVALDQCF
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QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV|DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIKR
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QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV
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DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIK
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QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV|DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIK
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LKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTCSFVLGAIACGVATAAAVTAGVAIAKCIRLESEVTAIKNCL[K][K][T][N][E][C][V][S][T]LGCGV[R]V[L]ATAV[R]ELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISKDLMTDAELA[R]AI[S][N]M[P]TSAGQIKLMLENRCMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPCEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSCGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPQDQFNVALDQCF
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G:ARG 156|G:ARG 163|G:ARG 229|G:ASN 145|G:ASN 233|G:CYS 147|G:GLU 146|G:LEU 158|G:LYS 142|G:LYS 143|G:PRO 235|G:SER 149|G:SER 232|G:THR 144|G:THR 150|G:VAL 148
|
9cb1
|
B
|
E
|
H
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV
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DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIKR
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LKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTCSFVLGAIACGVATAAAVTAGVAIAKCIRLESEVTAIKNCLKKTNECVSTLGCGVRVLATAVRELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISKDLMTDAELARAISNMPTSAGQIKLMLENRCMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPCEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSCGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPQDQFNVALDQCF
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QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV|DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIKR
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV
|
DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIK
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV|DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIK
|
LKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTCSFVLGAIACGVATAAAVTAGVAIAKCIRLESEVTAIKNCL[K][K][T][N][E][C][V][S][T]LGCGV[R]V[L]ATAV[R]ELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISKDLMTDAELA[R]AI[S][N]M[P]TSAGQIKLMLENRCMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPCEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSCGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPQDQFNVALDQCF
|
H:ARG 156|H:ARG 163|H:ARG 229|H:ASN 145|H:ASN 233|H:CYS 147|H:GLU 146|H:LEU 158|H:LYS 142|H:LYS 143|H:PRO 235|H:SER 149|H:SER 232|H:THR 144|H:THR 150|H:VAL 148
|
9cb1
|
C
|
F
|
I
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV
|
DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIKR
|
LKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTCSFVLGAIACGVATAAAVTAGVAIAKCIRLESEVTAIKNCLKKTNECVSTLGCGVRVLATAVRELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISKDLMTDAELARAISNMPTSAGQIKLMLENRCMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPCEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSCGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPQDQFNVALDQCF
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV|DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIKR
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV
|
DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIK
|
QGQLVQSGPEVKKPGATVKVSCRASAYPFGNYGITWVRQVPGQGLEWVGWISYTGHTKFPQNFQGRVTLTADTSTSTGYMELTSDDTAVYYCARGPCCSSDIWGQGTMVTV|DIQMTQSPSTLSASVGDRVTITCRASQSIDDWLAWYQHSPGKAPKLLIYRASRLESGVPSRFSGSGSGTEFTLTISSLQPDDFASYYCQQCYTYSQTFGQGTRVEIK
|
LKESYLEESCSTITEGYLSVLRTGWYTNVFTLEVGDVENLTCADGPSLIKTELDLTKSALRELRTCSFVLGAIACGVATAAAVTAGVAIAKCIRLESEVTAIKNCL[K][K][T][N][E][C][V][S][T]LGCGV[R]V[L]ATAV[R]ELKDFVSKNLTRAINKNKCDIPDLKMAVSFSQFNRRFLNVVRQFSDNAGITPAISKDLMTDAELA[R]AI[S][N]M[P]TSAGQIKLMLENRCMVRRKGFGILIGVYGSSVIYMVQLPIFGVIDTPCWIVKAAPSCSEKKGNYACLLREDQGWYCQNAGSTVYYPCEKDCETRGDHVFCDTAAGINVAEQSKECNINISTTNYPCKVSCGRHPISMVALSPLGALVACYKGVSCSIGSNRVGIIKQLNKGCSYITNQDADTVTIDNTVYQLSKVEGEQHVIKGRPVSSSFDPVKFPQDQFNVALDQCF
|
I:ARG 156|I:ARG 163|I:ARG 229|I:ASN 145|I:ASN 233|I:CYS 147|I:GLU 146|I:LEU 158|I:LYS 142|I:LYS 143|I:PRO 235|I:SER 149|I:SER 232|I:THR 144|I:THR 150|I:VAL 148
|
9mic
|
H
|
L
|
C
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
|
DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRPSGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDWRDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCASTQLFASTWF
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTVSS
|
IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIK
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTVSS|IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIK
|
DTITLPCRPAPPPHCSSNITGLIL[T][R][Q][G][G][Y]SNANTV[I]F[R]PS[G][G][D]W[R][D]IARCQIAGTVVSTQLFLNGSLAEEEVVIRSE[D]W[R][D][N][A][K]SICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIF[K]PS[S][G][G][D]PE[F]VNHSFNCGGEFFYCASTQLFASTWF
|
C:ALA 84|C:ARG 26|C:ARG 39|C:ARG 46|C:ARG 81|C:ASN 83|C:ASP 141|C:ASP 44|C:ASP 47|C:ASP 79|C:ASP 82|C:GLN 27|C:GLY 139|C:GLY 140|C:GLY 28|C:GLY 29|C:GLY 42|C:GLY 43|C:ILE 37|C:LYS 135|C:LYS 85|C:PHE 144|C:SER 138|C:THR 25|C:TYR 30
|
9mid
|
H
|
L
|
C
|
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGHYMHWVRQAPGQGLEWMGWINYSSGTNYAQNFQGRVTMTRDTSITTAYMELRSDDTAVYYCARAPDYGDDYWGQGTLVTVFNQIKGPSVFPLAPAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSLGTQTYICNVNHKPSNTKVDKKVEP
|
ALTQPPSASGSPGQSVTISCTGNYVSWYQQHPGKAPKVIIYEVSKRPSGVPDRFSGSKSGNTASLTVSGLQADDEADYYCSSYEVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT
|
DTITLPCRPAPPPHCSSNITGLILTRQGGANTVIFRPSGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDWRDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCASTQLFASTWF
|
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGHYMHWVRQAPGQGLEWMGWINYSSGTNYAQNFQGRVTMTRDTSITTAYMELRSDDTAVYYCARAPDYGDDYWGQGTLVTVFNQIKGPSVFPLAPAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSLGTQTYICNVNHKPSNTKVDKKVEP|ALTQPPSASGSPGQSVTISCTGNYVSWYQQHPGKAPKVIIYEVSKRPSGVPDRFSGSKSGNTASLTVSGLQADDEADYYCSSYEVFGTGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT
|
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGHYMHWVRQAPGQGLEWMGWINYSSGTNYAQNFQGRVTMTRDTSITTAYMELRSDDTAVYYCARAPDYGDDYWGQGTLVTVFN
|
ALTQPPSASGSPGQSVTISCTGNYVSWYQQHPGKAPKVIIYEVSKRPSGVPDRFSGSKSGNTASLTVSGLQADDEADYYCSSYEVFGTGTKVTVL
|
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGHYMHWVRQAPGQGLEWMGWINYSSGTNYAQNFQGRVTMTRDTSITTAYMELRSDDTAVYYCARAPDYGDDYWGQGTLVTVFN|ALTQPPSASGSPGQSVTISCTGNYVSWYQQHPGKAPKVIIYEVSKRPSGVPDRFSGSKSGNTASLTVSGLQADDEADYYCSSYEVFGTGTKVTVL
|
DTITLPCRPAPPPHCSSNITGLIL[T][R][Q][G][G]ANTV[I]F[R]P[S][G][G][D][W][R][D]IARCQIAGTVVSTQLFLNGSLAEEEVVIRS[E][D]W[R][D][N][A][K]SICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIF[K]PS[S][G][G][D]P[E][F]VNHSFNCGGEFFYCASTQLFASTWF
|
C:ALA 84|C:ARG 26|C:ARG 39|C:ARG 46|C:ARG 81|C:ASN 83|C:ASP 141|C:ASP 44|C:ASP 47|C:ASP 79|C:ASP 82|C:GLN 27|C:GLU 143|C:GLU 78|C:GLY 139|C:GLY 140|C:GLY 28|C:GLY 29|C:GLY 42|C:GLY 43|C:ILE 37|C:LYS 135|C:LYS 85|C:PHE 144|C:SER 138|C:SER 41|C:THR 25|C:TRP 45
|
9mif
|
H
|
L
|
C
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
|
DTITLPCRPAPPPHCSSNITGLILTRQGGYSNANTVIFRPSGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDWRDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCASTQLFASTWF
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGEC
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
|
NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEIK
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEIK
|
DTITLPCRPAPPPHCSSNITGLIL[T][R][Q][G][G][Y][S]NANTV[I]F[R]PS[G][G][D][W][R][D]IARCQIAGTVVSTQLFLNGSLAEEEVVIRS[E][D]W[R][D][N][A][K][S]ICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPS[S][G][G][D]PE[F]VNHSFNCGGEFFYCASTQLFASTWF
|
C:ALA 84|C:ARG 26|C:ARG 39|C:ARG 46|C:ARG 81|C:ASN 83|C:ASP 141|C:ASP 44|C:ASP 47|C:ASP 79|C:ASP 82|C:GLN 27|C:GLU 78|C:GLY 139|C:GLY 140|C:GLY 28|C:GLY 29|C:GLY 42|C:GLY 43|C:ILE 37|C:LYS 85|C:PHE 144|C:SER 138|C:SER 31|C:SER 86|C:THR 25|C:TRP 45|C:TYR 30
|
9mj3
|
H
|
L
|
C
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSSASTKGPSVFPLAPSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
|
VLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGE
|
DTITLPCRPAPPPHCSSNITGLILTRQGGANTVIFRPSGGDWRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRSEDWRDNAKSICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIFKPSSGGDPEFVNHSFNCGGEFFYCASTQLFASTWF
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSSASTKGPSVFPLAPSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK|VLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTQGTTSVTKSFNRGE
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
DTITLPCRPAPPPHCSSNITGLIL[T][R][Q][G][G]ANTV[I]F[R]PS[G][G][D]WRDIARCQIAGTVVSTQLFLNGSLAEEEVVIRS[E][D]W[R][D][N][A][K]SICVQLATSVEIACTGAGHCAISRAKWANTLKQIASKLREQYGAKTIIF[K]PS[S][G][G][D]PE[F]VNHSFNCGGEFFYCASTQLFASTWF
|
C:ALA 84|C:ARG 26|C:ARG 39|C:ARG 81|C:ASN 83|C:ASP 141|C:ASP 44|C:ASP 79|C:ASP 82|C:GLN 27|C:GLU 78|C:GLY 139|C:GLY 140|C:GLY 28|C:GLY 29|C:GLY 42|C:GLY 43|C:ILE 37|C:LYS 135|C:LYS 85|C:PHE 144|C:SER 138|C:THR 25
|
9msy
|
G
|
I
|
A
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT
|
ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMWKNNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSENMMDNTKTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYYHNKTIKFEPSSGGDLEITTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMWQKVGRAMYAPPIAGNITCSSNITGLLLTRDGGRGTNGTETFRPAGGNMKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT|ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT
|
ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT|ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMW[K]NNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSE[N]M[M][D][N][T]KTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYY[H]N[K]TIKFEPS[S][G][G][D]L[E][I]TTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMW[Q]KVGRAMYAPPIAGNITCSSNITGLLLT[R][D][G][G][R][G]TNGTE[T]F[R]PA[G][G][N]MKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
A:ARG 456|A:ARG 460|A:ARG 469|A:ASN 276|A:ASN 280|A:ASN 474|A:ASP 279|A:ASP 368|A:ASP 457|A:GLN 428|A:GLU 370|A:GLY 366|A:GLY 367|A:GLY 458|A:GLY 459|A:GLY 461|A:GLY 472|A:GLY 473|A:HIS 354|A:ILE 371|A:LYS 356|A:LYS 97|A:MET 278|A:SER 365|A:THR 281|A:THR 467
|
9msy
|
H
|
L
|
A
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT
|
EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMWKNNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSENMMDNTKTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYYHNKTIKFEPSSGGDLEITTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMWQKVGRAMYAPPIAGNITCSSNITGLLLTRDGGRGTNGTETFRPAGGNMKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT|EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT
|
EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT|EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMW[K]NNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSE[N]M[M][D][N][T]KTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYY[H]N[K]TIKFEPS[S][G][G][D]L[E][I]TTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMW[Q]KVGRAMYAPPIAGNITCSSNITGLLLT[R][D][G][G][R][G]TNGTE[T]F[R]PA[G][G][N]MKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
A:ARG 456|A:ARG 460|A:ARG 469|A:ASN 276|A:ASN 280|A:ASN 474|A:ASP 279|A:ASP 368|A:ASP 457|A:GLN 428|A:GLU 370|A:GLY 366|A:GLY 367|A:GLY 458|A:GLY 459|A:GLY 461|A:GLY 472|A:GLY 473|A:HIS 354|A:ILE 371|A:LYS 356|A:LYS 97|A:MET 278|A:SER 365|A:THR 281|A:THR 467
|
9msy
|
J
|
M
|
B
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT
|
ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMWKNNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSENMMDNTKTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYYHNKTIKFEPSSGGDLEITTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMWQKVGRAMYAPPIAGNITCSSNITGLLLTRDGGRGTNGTETFRPAGGNMKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
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VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT|ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
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VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT
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ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
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VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT|ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
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LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMW[K]NNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSE[N]M[M][D][N][T]KTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYY[H]N[K]TIKFEPS[S][G][G][D]L[E][I]TTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMW[Q]KVGRAMYAPPIAGNITCSSNITGLLLT[R][D][G][G][R][G]TNGTE[T]F[R]PA[G][G][N]MKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
B:ARG 456|B:ARG 460|B:ARG 469|B:ASN 276|B:ASN 280|B:ASN 474|B:ASP 279|B:ASP 368|B:ASP 457|B:GLN 428|B:GLU 370|B:GLY 366|B:GLY 367|B:GLY 458|B:GLY 459|B:GLY 461|B:GLY 472|B:GLY 473|B:HIS 354|B:ILE 371|B:LYS 356|B:LYS 97|B:MET 278|B:SER 365|B:THR 281|B:THR 467
|
9msy
|
K
|
N
|
B
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT
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EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
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LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMWKNNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSENMMDNTKTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYYHNKTIKFEPSSGGDLEITTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMWQKVGRAMYAPPIAGNITCSSNITGLLLTRDGGRGTNGTETFRPAGGNMKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
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VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT|EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT
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EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
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VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT|EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMW[K]NNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSE[N]M[M][D][N][T]KTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYY[H]N[K]TIKFEPS[S][G][G][D]L[E][I]TTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMW[Q]KVGRAMYAPPIAGNITCSSNITGLLLT[R][D][G][G][R][G]TNGTE[T]F[R]PA[G][G][N]MKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
B:ARG 456|B:ARG 460|B:ARG 469|B:ASN 276|B:ASN 280|B:ASN 474|B:ASP 279|B:ASP 368|B:ASP 457|B:GLN 428|B:GLU 370|B:GLY 366|B:GLY 367|B:GLY 458|B:GLY 459|B:GLY 461|B:GLY 472|B:GLY 473|B:HIS 354|B:ILE 371|B:LYS 356|B:LYS 97|B:MET 278|B:SER 365|B:THR 281|B:THR 467
|
9msy
|
O
|
Q
|
C
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT
|
ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMWKNNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSENMMDNTKTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYYHNKTIKFEPSSGGDLEITTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMWQKVGRAMYAPPIAGNITCSSNITGLLLTRDGGRGTNGTETFRPAGGNMKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT|ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT
|
ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
VQLRESGPGLVKPSETLSLSCTVSNDSRPSDHSWWVRQSPGKALEWIGDIHYNGATTYNPSLRSRVRIELDQSIPRFSLKMTAADTGMYYCARNAIRIYDVWGQGTAVT|ELTQPPSVSVSPGQTARITCSGAPLTSRFTYWYRQKPGQAPVLIISRSSQRSSGWSGRFSASWSGTTVTLTIRGVQADDEADYYCQSSDTSDKMFGGGTKLTV
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMW[K]NNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSE[N]M[M][D][N][T]KTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYY[H]N[K]TIKFEPS[S][G][G][D]L[E][I]TTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMW[Q]KVGRAMYAPPIAGNITCSSNITGLLLT[R][D][G][G][R][G]TNGTE[T]F[R]PA[G][G][N]MKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
C:ARG 456|C:ARG 460|C:ARG 469|C:ASN 276|C:ASN 280|C:ASN 474|C:ASP 279|C:ASP 368|C:ASP 457|C:GLN 428|C:GLU 370|C:GLY 366|C:GLY 367|C:GLY 458|C:GLY 459|C:GLY 461|C:GLY 472|C:GLY 473|C:HIS 354|C:ILE 371|C:LYS 356|C:LYS 97|C:MET 278|C:SER 365|C:THR 281|C:THR 467
|
9msy
|
P
|
R
|
C
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT
|
EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMWKNNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSENMMDNTKTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYYHNKTIKFEPSSGGDLEITTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMWQKVGRAMYAPPIAGNITCSSNITGLLLTRDGGRGTNGTETFRPAGGNMKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT|EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT
|
EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
VQLVQSGAELKKPGASVKVSCKASGYTFTDSYMHWVRQAPGQGLEWMGWINNYGATNYAHKFQGRVTMTRDTSITTAYMELRSDDTAVYYCARGNFLRVQHWGQGTLVT|EIVLTQSPGTLSLSPGEGATLSCRTSQLSSSSLAWYQQKPGLAPRLLIYGASIRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEFFGAGTRVE
|
LWVTVYYGVPVWRDAITTLFCASDANVWATCVPTPQEMVLENVTENFNMW[K]NNMVDQMHEDIISLWDQSLKPCVQLTPLCVTLNCTDVTGIKNCSFNITTEVRDKKKKVHALFYRLDIVPISTEYILINCNTSVITQICPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTIQCTHGIKPVVSTQLLLNGSLAEEDIIISSE[N]M[M][D][N][T]KTIIVHFNESVGIECTRPNNNTVESIRIGPGQTFYVTGEIGDIRQAHCNISKGNWSKTLQRVKEKLKKYY[H]N[K]TIKFEPS[S][G][G][D]L[E][I]TTHSFNCRGEFFYCYTSGLFNEGTNGTITLPCRIKQIVNMW[Q]KVGRAMYAPPIAGNITCSSNITGLLLT[R][D][G][G][R][G]TNGTE[T]F[R]PA[G][G][N]MKDNWRSELYKYKVVEIKPLGIAPTKCRRFLGAAGSTMGAVQTRQLLSGFVQGIKQLQTRVLAIERYLEVQQFLGLWGCSGKAICCTAVPWNTTWSNKSEQEIWNNMTWMQWDREVGNYTDTIYKLLFVAQFQQEINEVD
|
C:ARG 456|C:ARG 460|C:ARG 469|C:ASN 276|C:ASN 280|C:ASN 474|C:ASP 279|C:ASP 368|C:ASP 457|C:GLN 428|C:GLU 370|C:GLY 366|C:GLY 367|C:GLY 458|C:GLY 459|C:GLY 461|C:GLY 472|C:GLY 473|C:HIS 354|C:ILE 371|C:LYS 356|C:LYS 97|C:MET 278|C:SER 365|C:THR 281|C:THR 467
|
9mih
|
H
|
L
|
A
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTV
|
IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIK
|
NLWVTVYYGVPVWKDAETTLFCASTHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTV|IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIK
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTV
|
IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIK
|
QVQLVQSGAEVKKPGASVKVSCKTSGYTFTDFYMHWMRQAPGQGLEWMGWINTGGGVNYAHKFQGRVTMTRDTSISTAYMELTSDDTGVYYCARSPARELDYWGQGTLVTV|IQVTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYGASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQIYETFGQGTKVDIK
|
NLWVTVYYGVPVWKDAETTLFCASTHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENI[T][N][N][A][K]NILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANS[S][G][G][D]LE[V]TTHSFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMW[Q]R[I]GQAMYAPPIQGVIRCVSNITGLIL[T][R][D][G][G][S][T]NSTTE[T]F[R]PGGGDMRDNW[R]SELYKYKVVKIEPLGVAPTRCKR
|
A:ALA 281|A:ARG 456|A:ARG 469|A:ARG 480|A:ASN 279|A:ASN 280|A:ASP 368|A:ASP 457|A:GLN 428|A:GLY 366|A:GLY 367|A:GLY 458|A:GLY 459|A:ILE 430|A:LYS 282|A:SER 365|A:SER 460|A:THR 278|A:THR 455|A:THR 461|A:THR 467|A:VAL 371
|
9mih
|
G
|
I
|
D
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
LGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
LGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQE[K][N]E[Q][D][L]L[A][L][D]
|
D:ALA 662|D:ASN 656|D:ASP 659|D:ASP 664|D:GLN 658|D:LEU 660|D:LEU 663|D:LYS 655
|
9mih
|
J
|
K
|
F|C
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
LGFLGAAGSTMGAASMTLTVQARNLLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD|NLWVTVYYGVPVWKDAETTLFCASNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWIDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
LGFLGAAGSTMGAASMTLTVQARNLLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQN[Q]QE[K][N]E[Q][D][L]L[A][L][D]|NLWVTVYYGVPVWKDAETTLFCASNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWIDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAP[T][R]CKR
|
F:ALA 662|F:ASN 656|F:ASP 659|F:ASP 664|F:GLN 652|F:GLN 658|F:LEU 660|F:LEU 663|F:LYS 655|C:ARG 500|C:THR 499
|
9mih
|
M
|
N
|
B|E
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
LGFLGAAGSTMGAASMTLTVQARNLLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD|NLWVTVYYGVPVWKDAETTLFCASNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWIDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTVS|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTVL
|
LGFLGAAGSTMGAASMTLTVQARNLLTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQE[K][N]E[Q][D][L]L[A][L][D]|NLWVTVYYGVPVWKDAETTLFCASNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWIDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAP[T][R]CKR
|
B:ALA 662|B:ASN 656|B:ASP 659|B:ASP 664|B:GLN 658|B:LEU 660|B:LEU 663|B:LYS 655|E:ARG 500|E:THR 499
|
9btl
|
H
|
L
|
E|I|A
|
QVQLQQWGEGLVKPSETLSLSCAVYGGSISGHYYWWIRQAPGKGLEWIGKIDNSASTNYNPSFKNRVSISKDTSKKQFYLNLTAADTAVYYCARGSIYYEHLWGQGVVVTVSS
|
QSVLTQPPSASEAARKRVSISCSGSFIGTNSVSWYQHLPGTAPKLLIYHNGQRASGVSDRFSGSKSGTSASLAISALQTEDEADYYCATWDDMLYFFGAGTRL
|
NLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINEKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV|NLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV|NLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
QVQLQQWGEGLVKPSETLSLSCAVYGGSISGHYYWWIRQAPGKGLEWIGKIDNSASTNYNPSFKNRVSISKDTSKKQFYLNLTAADTAVYYCARGSIYYEHLWGQGVVVTVSS|QSVLTQPPSASEAARKRVSISCSGSFIGTNSVSWYQHLPGTAPKLLIYHNGQRASGVSDRFSGSKSGTSASLAISALQTEDEADYYCATWDDMLYFFGAGTRL
|
QVQLQQWGEGLVKPSETLSLSCAVYGGSISGHYYWWIRQAPGKGLEWIGKIDNSASTNYNPSFKNRVSISKDTSKKQFYLNLTAADTAVYYCARGSIYYEHLWGQGVVVTVSS
|
QSVLTQPPSASEAARKRVSISCSGSFIGTNSVSWYQHLPGTAPKLLIYHNGQRASGVSDRFSGSKSGTSASLAISALQTEDEADYYCATWDDMLYFFGAGTRL
|
QVQLQQWGEGLVKPSETLSLSCAVYGGSISGHYYWWIRQAPGKGLEWIGKIDNSASTNYNPSFKNRVSISKDTSKKQFYLNLTAADTAVYYCARGSIYYEHLWGQGVVVTVSS|QSVLTQPPSASEAARKRVSISCSGSFIGTNSVSWYQHLPGTAPKLLIYHNGQRASGVSDRFSGSKSGTSASLAISALQTEDEADYYCATWDDMLYFFGAGTRL
|
NLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTL[Q][C][T]NVTNNITDDMRGELKNC[S]F[N]MTTEL[R][D][K][K][Q][K]V[Y]SLFYRLDVVQINE[K]EYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV|NLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCV[T]LQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQI[N]NKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV|NLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINNKEYRLINCNTSACTQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISDSITLPCRIKQIINMWQRIGQCMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
E:ARG 166|E:ASN 160|E:ASP 167|E:CYS 131|E:GLN 130|E:GLN 170|E:LYS 168|E:LYS 169|E:LYS 171|E:LYS 189|E:SER 158|E:THR 132|E:TYR 173|I:ASN 185|I:THR 128|
|
9cu5
|
D
|
E
|
A
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS
|
SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVLGQS
|
EKLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNATERGEIKNCSFNIVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRAVRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS|SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVLGQS
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS
|
SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVL
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS|SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVL
|
EKLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTDPNPQEVVL[E][N]V[T][E][H]FNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNATERGEIKNCSFNIVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKG[P]C[K]NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRAVRRGFLGAA[G][S][T]MGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNK[S]L[D][R]IW[N][N]M[T]WM[E]WEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
A:ARG 621|A:ASN 624|A:ASN 625|A:ASN 88|A:ASP 620|A:GLU 630|A:GLU 87|A:GLU 91|A:GLY 527|A:HIS 92|A:LYS 240|A:PRO 238|A:SER 528|A:SER 618|A:THR 529|A:THR 627|A:THR 90
|
9cu5
|
F
|
G
|
C
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTV
|
SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVLGQS
|
EKLWVTVYYGVPVWKDAETTLFCASDAKATEKHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNATMERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTV|SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVLGQS
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTV
|
SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVL
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTV|SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVL
|
EKLWVTVYYGVPVWKDAETTLFCASDAKAT[E]KHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPC[V]KLTPLCVTLNCKDVNATMERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQA[C][P][K]ISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPN[N][Y][T][R][K][S][I][R]IGP[G][R][A]F[Y]TMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPI[R]GQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
C:ALA 316|C:ARG 304|C:ARG 308|C:ARG 315|C:ARG 440|C:ASN 301|C:CYS 205|C:GLU 64|C:GLY 314|C:ILE 307|C:LYS 207|C:LYS 305|C:PRO 206|C:SER 306|C:THR 303|C:TYR 302|C:TYR 318|C:VAL 120
|
9cu5
|
J
|
K
|
B
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS
|
SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVLGQS
|
EKLWVTVYYGVPVWKDAETTLFCASDAKEKHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNAERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS|SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVLGQS
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS
|
SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVL
|
GQLVQSGAELKKPGASVKISCKTSGYRFNFYHINWIRQTAGRGPEWMGWISYSGDKNLAPAFQDRVIMTTDTSTGAAYMEIKFDDTGTYFCAKGLLRDGYLWGQGTLLTVS|SVLTQSASVSGSLGQSVTISCTGPNCSHKSISWYQWPPGRAPTLIIYEDNERAPGISPRFSGYKSYWSAYLTISDLRPEDETTYYCCSYTHNSCVFGTGTKVSVL
|
EKLWVTVYYGVPVWKDAETTLFCASDAKEKHNVWATHACVPTDPNPQEVVL[E][N]V[T]E[H]FNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNAERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKG[P]C[K]NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRGFLGAA[G][S][T]MGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSL[D][R]IW[N][N][M][T]W[M][E]WEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
B:ARG 621|B:ASN 624|B:ASN 625|B:ASN 88|B:ASP 620|B:GLU 630|B:GLU 87|B:GLY 527|B:HIS 92|B:LYS 240|B:MET 626|B:MET 629|B:PRO 238|B:SER 528|B:THR 529|B:THR 627|B:THR 90
|
9cu5
|
H
|
L
|
B
|
QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV
|
DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
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EKLWVTVYYGVPVWKDAETTLFCASDAKEKHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNAERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
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QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV|DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
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QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV
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DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
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QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV|DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
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EKLWVTVYYGVPVWKDAETTLFCASDAKEKHNVWATHACVPTDPNPQEVVL[E][N]V[T]E[H]FNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNAERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKG[P]C[K]NVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRGFLGAA[G][S][T]MGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSL[D][R]IW[N][N][M][T]W[M][E]WEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
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B:ARG 621|B:ASN 624|B:ASN 625|B:ASN 88|B:ASP 620|B:GLU 630|B:GLU 87|B:GLY 527|B:HIS 92|B:LYS 240|B:MET 626|B:MET 629|B:PRO 238|B:SER 528|B:THR 529|B:THR 627|B:THR 90
|
9cu5
|
I
|
M
|
C
|
QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV
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DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
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EKLWVTVYYGVPVWKDAETTLFCASDAKATEKHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPCVKLTPLCVTLNCKDVNATMERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQACPKISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPNNYTRKSIRIGPGRAFYTMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPIRGQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV|DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
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QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV
|
DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
|
QVQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV|DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
|
EKLWVTVYYGVPVWKDAETTLFCASDAKAT[E]KHNVWATHACVPTDPNPQEVVLENVTEHFNMWKNNMVEQMQTDIISLWDQSLKPC[V]KLTPLCVTLNCKDVNATMERGEIKNCSFNITTELRDKVQKVYALFYKLDVVPIDNNNTSYRLISCDTSVITQA[C][P][K]ISFEPIPIHYCAPAGFAILKCNDKTFNGKGPCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSDNFTNNAKTIIVQLKESVEINCTRPN[N][Y][T][R][K][S][I][R]IGP[G][R][A]F[Y]TMGEIGDIRQAHCNISRAKWNDTLKQIVIKLREQFENKTIVFNHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNNTEGNTITLPCRIKQIINMWQRVGQAMYAPPI[R]GQIRCSSNITGLLLTRDENGTEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVRRGFLGAAGSTMGAASMTLTVQARNLLSLGVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICTTAVPWNASWSNKSLDRIWNNMTWMEWEREIDNYTSEIYTLIEESQNQQEKNEQELLCL
|
C:ALA 316|C:ARG 304|C:ARG 308|C:ARG 315|C:ARG 440|C:ASN 301|C:CYS 205|C:GLU 64|C:GLY 314|C:ILE 307|C:LYS 207|C:LYS 305|C:PRO 206|C:SER 306|C:THR 303|C:TYR 302|C:TYR 318|C:VAL 120
|
9cv7
|
H
|
L
|
B|C
|
VQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV
|
DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
|
MGSLWVTVYYGVPVWRDAETTLFCASDAKAYETEKHSVWATHACVPTDPNPQEMVLENVTENFNMWKNDMVDQMHTDVISIWDQSLKPCVKLTPLCVTLDCSTYNNTHNISKEMKICSFNMTTELRDKKRKVNVLFYKLDLVPLTNYRLISCNTSTITQACPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRFENLTDNVKIIIVQLNETINITCTRPNNYTRKSIRIGPGQSFYAMGEIGNIREAHCNISASKWNKTLERVRTKLKEHFPNKTIEFEPSSGGDLEITTHSFNCGGEFFYCNTSGLFNSAINGTLTSNVTLPCRIKQIINMWQRVGQAMYAPPIAGNITCKSNITGLLLTRDTFRPTGGDMKNNWRSELYKYKVVEIKPLGIAPTRCKRRFLGAAGSTMGAASMTLTVQARQLLSVWGIKQLQARVLAIERYLKDQQLLGLWGCSGKLICTTNVPWNASWSNKSKNDIWDNMTWMQWDREIGNHTDTIYRLLEDSQNQQEKNEKDLLCL|GSLWVTVYYGVPVWRDAETTLFCASDAKAYETATHACVPTDPNPQEMVLENVTENFNMWKNDMVDQMHTDVISIWDQSLKPCVKLTPLCVTLDCSTYNNTHNISKEMKICSFNMTTELRDKKRKVNVLFYKLDLVPLTNYRLISCNTSTITQACPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRFENLTDNVKIIIVQLNETINITCTRPNNYTRKSIRIGPGQSFYAMGEIGNIREAHCNISASKWNKTLERVRTKLKEHFPNKTIEFEPSSGGDLEITTHSFNCGGEFFYCNTSGLFNSAINGTLTSNVTLPCRIKQIINMWQRVGQAMYAPPIAGNITCKSNITGLLLTRDTFRPTGGDMKNNWRSELYKYKVVEIKPLGIAPTRFLGAAGSTMGAASMTLTVQARQLLSVWGIKQLQARVLAIERYLKDQQLLGLWGCSGKLICTTNVPWNASWSNKSKNDIWDNMTWMQWDREIGNHTDTIYRLLEDSQNQQEKNEKDLLCL
|
VQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV|DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
|
VQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV
|
DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
|
VQLQESGPGLVKPSETLSLTCTVSGGSIDDYFWNWVRQPPGKPLECIGYIFRGGGTKYNPSLDNRVTISTDTPNQFSLKLTVADTAIYYCARWNLYDDAVWGRGVLVTV|DIQMTQSPSSLSASVGDTVTITCQARHAVGKNLNWYQQKPGRGPQLLIYMASSRHSGVPSRFRGSGSGREFTLTINNLQPEDFATYSCQQGYTYPWTFGQGTKVEM
|
MGSLWVTVYYGVPVWRDAETTLFCASDAKA[Y]ET[E][K]HSVWATHACVPTDPNPQEMVLENVTENFNMWKNDMVDQMHTDVISIWDQSLKPCVKLTPLCVTLDCSTYNNTHNISKEMKICSFNMTTELRDKKRKVNVLFYKLDLVPLTNYRLISCNTSTITQA[C][P][K]VSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRFENLTDNVKIIIVQLNETINITCTRPNNY[T][R][K][S][I][R]IGP[G][Q][S]F[Y]AMGEIGNIREAHCNISASKWNKTLERVRTKLKEHFPNKTIEFEPSSGGDLEITTHSFNCGGEFFYCNTSGLFNSAINGTLTSNVTLPCRIKQIINMWQRVGQAMYAPPIAGNITCKSNITGLLLTRDTFRPTGGDMKNNWRSELYKYKVVEIKPLGIAPTRCKRRFLGAAGSTMGAASMTLTVQARQLLSVWGIKQLQARVLAIERYLKDQQLLGLWGCSGKLICTTNVPWNASWSNKSKNDIWDNMTWMQWDREIGNHTDTIYRLLEDSQNQQEKNEKDLLCL|GSLWVTVYYGVPVWRDAETTLFCASDAKAYETATHACVPTDPNPQEMVLENVTENFNMWKNDMVDQMHTDVISIWDQSLKPCVKLTPLCVTLDCSTYNNTHNISKEMKICSFNMTTELRDKKRKVNVLFYKLDLVPLTNYRLISCN[T]STITQACPKVSFDPIPIHYCAPAGYAILKCNNKTFNGTGPCNNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRF[E]NLTD[N][V][K]IIIVQLNETINITCTRPNNYTRKSIRIGPGQSFYAMGEIGNIREAHCNISASKWNKTLERVRTKLKEHFPNKTIEFEPSSGGD[L]EI[T]THSFNCGGEFFYCNTSGLFNSAINGTLTSNVTLPCRIKQIINMWQ[R][V][G]QAMYAPPIAGNITCKSNITGLLLTRDTFRPTG[G][D][M]KNNWRSELYKYKVVEIKPLGIAPTRFLGAAGSTMGAASMTLTVQARQLLSVWGIKQLQARVLAIERYLKDQQLLGLWGCSGKLICTTNVPWNASWSNKSKNDIWDNMTWMQWDREIGNHTDTIYRLLEDSQNQQEKNEKDLLCL
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B:ARG 304|B:ARG 308|B:CYS 205|B:GLN 315|B:GLU 64|B:GLY 314|B:ILE 307|B:LYS 207|B:LYS 305|B:LYS 65|B:PRO 206|B:SER 306|B:SER 316|B:THR 303|B:TYR 318|B:TYR 61|C:ARG 429|C:ASN 280|C:ASP 368|C:ASP 474|C:GLN 428|C:GLU 275|C:GLY 472|C:GLY 473|C:ILE 371|C:LYS 282|C:THR 198|C:VAL 281|C:VAL 430
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9ehl
|
G
|
J
|
A
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS
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SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS
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SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
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VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T][N][N]ITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I][G][D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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A:ARG 327|A:ASN 136|A:ASN 137|A:ASP 325|A:GLN 328|A:GLY 324|A:HIS 330|A:ILE 322|A:ILE 323|A:ILE 326|A:LEU 416|A:PRO 417|A:THR 135|A:THR 415
|
9ehl
|
H
|
K
|
B
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS
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SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS
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SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T][N][N]ITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I]G[D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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B:ARG 327|B:ASN 136|B:ASN 137|B:ASP 325|B:GLN 328|B:GLY 324|B:HIS 330|B:ILE 322|B:ILE 326|B:LEU 416|B:PRO 417|B:THR 135|B:THR 415
|
9ehl
|
I
|
L
|
C
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS
|
SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS
|
SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGGVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T][N][N]ITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I][G][D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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C:ARG 327|C:ASN 136|C:ASN 137|C:ASP 325|C:GLN 328|C:GLY 324|C:HIS 330|C:ILE 322|C:ILE 323|C:ILE 326|C:LEU 416|C:PRO 417|C:THR 135|C:THR 415
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9ehl
|
M
|
P
|
A
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS
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VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS|VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS
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LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS|LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T][N][N]ITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I][G][D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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A:ARG 327|A:ASN 136|A:ASN 137|A:ASP 325|A:GLN 328|A:GLY 324|A:HIS 330|A:ILE 322|A:ILE 323|A:ILE 326|A:LEU 416|A:PRO 417|A:THR 135|A:THR 415
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9ehl
|
N
|
Q
|
B
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS
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VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS|VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS
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LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS|LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T][N][N]ITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I]G[D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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B:ARG 327|B:ASN 136|B:ASN 137|B:ASP 325|B:GLN 328|B:GLY 324|B:HIS 330|B:ILE 322|B:ILE 326|B:LEU 416|B:PRO 417|B:THR 135|B:THR 415
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9ehl
|
O
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R
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C
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS
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VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS|VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS
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LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
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QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS|LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T][N][N]ITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I][G][D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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C:ARG 327|C:ASN 136|C:ASN 137|C:ASP 325|C:GLN 328|C:GLY 324|C:HIS 330|C:ILE 322|C:ILE 323|C:ILE 326|C:LEU 416|C:PRO 417|C:THR 135|C:THR 415
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9ehm
|
H
|
K
|
B
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VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS
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SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
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NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNIGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS
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SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
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VQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVT[N][N]IGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATG[I][I][G][D][I][R][Q][A]HCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
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B:ARG 327|B:ASN 136|B:ASN 137|B:ASP 321|B:ASP 325|B:GLN 328|B:GLY 324|B:ILE 322|B:ILE 323|B:ILE 326|B:LEU 416|B:PRO 417|B:THR 415
|
9ehm
|
I
|
L
|
C
|
QVQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS
|
SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
VTVYYGVPVWKDAETTLFCASDAKTEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
QVQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSSAS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVLGQP
|
QVQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS
|
SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
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QVQLVQSGAQVKKPGASVTVSCTASGYTFTGYHMHWVRQAPGQGLEWMGWINFRGAVKYAQKFRGRVSMTRDTSIEIFYMELRSDDTAVYYCAREMFDSSVAWGQGTLVTVSS|SALTQPASVSGSPGQSITISCTGSSGGFDLVSWYQQHPGKAPKLMIYEVSKRPSGVSNRFSASKSGNTASLTISGLQAEDEADYYCYSYADGVAFGGGTKLTVL
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VTVYYGVPVWKDAETTLFCASDAKTEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVT[N][N]I[T][D]DGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I]G[D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
C:ARG 327|C:ASN 136|C:ASN 137|C:ASP 140|C:ASP 325|C:GLN 328|C:GLY 324|C:HIS 330|C:ILE 322|C:ILE 326|C:LEU 416|C:PRO 417|C:THR 139|C:THR 415
|
9ehm
|
M
|
P
|
A
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS
|
VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
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NLWVTVYYGVPVWKDAETTLFCASDATEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS|VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS
|
LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS|LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
|
NLWVTVYYGVPVWKDAETTLFCASDATEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNV[T]NGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I][G][D][I][R][Q][A]HCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLP[C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
A:ARG 327|A:ASP 325|A:GLN 328|A:GLY 324|A:ILE 322|A:ILE 323|A:ILE 326|A:PRO 417|A:THR 135
|
9ehm
|
N
|
Q
|
B
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS
|
VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNIGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS|VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS
|
LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS|LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVT[N][N]IGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATG[I][I][G][D][I][R][Q][A]HCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
B:ARG 327|B:ASN 136|B:ASN 137|B:ASP 321|B:ASP 325|B:GLN 328|B:GLY 324|B:ILE 322|B:ILE 323|B:ILE 326|B:LEU 416|B:PRO 417|B:THR 415
|
9ehm
|
O
|
R
|
C
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS
|
VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
|
VTVYYGVPVWKDAETTLFCASDAKTEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSSAS|VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVLGQP
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS
|
LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
|
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLTPADTAVYYCATARRGQRDVWGKGTTVTVSS|LSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPFGTRATLTISGVEAGDEADYYCHMWDSRSWSFGGATRLTVL
|
VTVYYGVPVWKDAETTLFCASDAKTEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVT[N][N]I[T][D]DGELKNCSFNMTTELRDKKQKVYSLFYRLDVVQINKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSENITNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQAFYATGI[I]G[D][I][R][Q][A]H[C]NVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNNDSIT[L][P][C]RIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRV
|
C:ARG 327|C:ASN 136|C:ASN 137|C:ASP 140|C:ASP 325|C:GLN 328|C:GLY 324|C:HIS 330|C:ILE 322|C:ILE 326|C:LEU 416|C:PRO 417|C:THR 139|C:THR 415
|
9f90
|
A
|
B
|
H
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
|
DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG
|
SMKYMLVKADDYYFLLPPKDVEKIESALKSTNKAVVSFFDKENNKTYEFTFNKDLVVTEVRETDKNRGIIKTFSVKEVKFFDNKEELLEYINDLPISNDDKKLLSNNIDEFLVVKAK
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP|DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSS
|
DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIK
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSS|DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIK
|
SMKYMLVKADDYYFLLPPKDVEKIESALKSTNKAVVSFFDKENNKTYEFTFNKDLVVTEVRETDKNRGIIKTFSVKEVKFFDNK[E]EL[L][E]Y[I][N]DLPIS[N][D]D[K][K]LL[S][N]NIDEFLVVKAK
|
H:ASN 105|H:ASN 91|H:ASN 97|H:ASP 98|H:GLU 84|H:GLU 88|H:ILE 90|H:LEU 87|H:LYS 100|H:LYS 101|H:SER 104
|
9f90
|
D
|
C
|
G
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
|
DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
|
MKYMLVKADDYYFLLPPKDVEKIESALKSTNKVVSFFDKENNKTYEFTFNKDLVVTEVRETDKNRGIIKTFSVKEVKFFDNKEELLEYINDLPISNDDKKLLSNNIDEFLVVKAK
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSSASTKGPSVFPLAPTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP|DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSS
|
DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIK
|
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVDPADTATYYCARDMIFNFDVWGQGTTVTVSS|DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIK
|
MKYMLVKADDYYFLLPPKDVEKIESALKSTNKVVSFFDKENNKTYEFTFNKDLVVTEVRETDKNRGIIKTFSVKEVKFFDNK[E]EL[L][E]YI[N][D]LPIS[N][D]D[K][K]LL[S][N]NIDEFLVVKAK
|
G:ASN 105|G:ASN 91|G:ASN 97|G:ASP 92|G:ASP 98|G:GLU 84|G:GLU 88|G:LEU 87|G:LYS 100|G:LYS 101|G:SER 104
|
9f91
|
E
|
F
|
I
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSSASTKGPSVFPLAPSSKTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
|
TGEIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQRTVAAPSVFIFPPSDSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
TEEEIIEKVKSALLSTNKAVISVELKGRTIPLYVEITKEGKLHLTAEGATEEEKEIIKEAQKAFQEEIEH
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSSASTKGPSVFPLAPSSKTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP|TGEIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQRTVAAPSVFIFPPSDSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSS
|
EIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQ
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSS|EIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQ
|
TEEEIIEKV[K][S][A][L][L][S][T][N][K][A][V]I[S]VELKGRTIPLYVEIT[K]EGKLHLTAEGATEEEKEIIKEAQKAFQEEIEH
|
I:ALA 14|I:ALA 21|I:ASN 19|I:LEU 15|I:LEU 16|I:LYS 12|I:LYS 20|I:LYS 40|I:SER 13|I:SER 17|I:SER 24|I:THR 18|I:VAL 22
|
9f91
|
A
|
B
|
J
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
|
TGEIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
|
TEEEIIEKVKSALLSTNKAVISVELKGRTIPLYVEITKEGKLHLTAEGATEEEKEIIKEAQKAFQEEIE
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP|TGEIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSS
|
EIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQ
|
EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSS|EIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQ
|
TEEEIIEKV[K][S][A][L][L][S][T][N][K][A][V][I]SVELKGRTIPL[Y]VEIT[K][E]GKLHLTAEGATEEEKEIIKEAQKAFQEEIE
|
J:ALA 14|J:ALA 21|J:ASN 19|J:GLU 41|J:ILE 23|J:LEU 15|J:LEU 16|J:LYS 12|J:LYS 20|J:LYS 40|J:SER 13|J:SER 17|J:THR 18|J:TYR 35|J:VAL 22
|
9mi0
|
H
|
L
|
A
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKD[I][R]N[N][A][K][N][I]LVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGG[D][L][E][V]TT[H]SFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQR[I][G]Q[A]MYAPPIQGVIRCVSNITGLILTRD[G][G][S][T][D][S][T][T][E]TFRPS[G]GD[M]RDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
A:ALA 281|A:ARG 278|A:ARG 456|A:ARG 469|A:ASN 279|A:ASN 280|A:ASP 276|A:ASP 368|A:ASP 457|A:ASP 462|A:GLN 428|A:GLY 366|A:GLY 367|A:GLY 458|A:GLY 459|A:GLY 472|A:ILE 430|A:LYS 275|A:LYS 282|A:SER 365|A:SER 460|A:SER 463|A:THR 455|A:THR 461|A:TRP 427|A:VAL 371
|
9mi0
|
G
|
I
|
F
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEK[N][E]Q[D][L][L]A[L][D]
|
F:ASN 656|F:ASP 659|F:ASP 664|F:GLU 657|F:LEU 660|F:LEU 661|F:LEU 663
|
9mi0
|
K
|
N
|
C
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKD[I][R]N[N][A][K][N][I]LVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGG[D][L][E][V]TT[H]SFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQR[I][G]Q[A]MYAPPIQGVIRCVSNITGLILTRD[G][G][S][T][D][S][T][T][E]TFRPS[G]GD[M]RDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
C:ALA 281|C:ARG 278|C:ARG 456|C:ARG 469|C:ASN 279|C:ASN 280|C:ASP 276|C:ASP 368|C:ASP 457|C:ASP 462|C:GLN 428|C:GLY 366|C:GLY 367|C:GLY 458|C:GLY 459|C:GLY 472|C:ILE 430|C:LYS 275|C:LYS 282|C:SER 365|C:SER 460|C:SER 463|C:THR 455|C:THR 461|C:TRP 427|C:VAL 371
|
9mi0
|
J
|
M
|
B
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEK[N][E]Q[D][L][L]A[L][D]
|
B:ASN 656|B:ASP 659|B:ASP 664|B:GLU 657|B:LEU 660|B:LEU 661|B:LEU 663
|
9mi0
|
P
|
R
|
E
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS
|
VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
VQLVQSGAEVKQPGASVKVSCKASGYTFSDHFMHWVRQAPGQGLEWMGWINKSGGPNYAQKFQGRVTMTRDRSISTAYMELRSDDTAIYYCARPMHDYDDLWGRGTLVTVSS|VSVLTQSPGTLSLSPGERATLSCRASQVGSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYEAFGQGTKVEIK
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYETKKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINNTSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKD[I][R]N[N][A][K][N][I]LVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGIIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGG[D][L][E][V]TT[H]SFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQR[I][G]Q[A]MYAPPIQGVIRCVSNITGLILTRD[G][G][S][T][D][S][T][T][E]TFRPS[G]GD[M]RDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
E:ALA 281|E:ARG 278|E:ARG 456|E:ARG 469|E:ASN 279|E:ASN 280|E:ASP 276|E:ASP 368|E:ASP 457|E:ASP 462|E:GLN 428|E:GLY 366|E:GLY 367|E:GLY 458|E:GLY 459|E:GLY 472|E:ILE 430|E:LYS 275|E:LYS 282|E:SER 365|E:SER 460|E:SER 463|E:THR 455|E:THR 461|E:TRP 427|E:VAL 371
|
9mi0
|
O
|
Q
|
D
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEK[N][E]Q[D][L][L]A[L][D]
|
D:ASN 656|D:ASP 659|D:ASP 664|D:GLU 657|D:LEU 660|D:LEU 661|D:LEU 663
|
9mib
|
G
|
I
|
F
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEK[N][E]Q[D][L][L]A[L][D]
|
F:ASN 656|F:ASP 659|F:ASP 664|F:GLU 657|F:LEU 660|F:LEU 661|F:LEU 663
|
9mib
|
H
|
L
|
A
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
|
NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYEHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
|
NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYEHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSK[D][I]R[N][N][A][K][N]ILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSS[G][G][D][L]E[V][T]THSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIIN[M][W][Q][R]IGQAMYAPPIQGVIRCVSNITGLILT[R][D][G][G][S][T][D][S]TTETFR[P]SGG[D][M]RDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
A:ALA 281|A:ARG 278|A:ARG 456|A:ARG 469|A:ASN 279|A:ASN 280|A:ASN 425|A:ASP 276|A:ASP 368|A:ASP 457|A:ASP 462|A:ASP 474|A:GLN 428|A:GLU 370|A:GLY 366|A:GLY 367|A:GLY 458|A:GLY 459|A:GLY 473|A:LYS 275|A:LYS 282|A:MET 426|A:SER 365|A:SER 460|A:THR 455|A:THR 461|A:TRP 427|A:VAL 371
|
9mib
|
J
|
M
|
B
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
|
ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
|
VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEK[N][E]Q[D][L][L]A[L][D]
|
B:ASN 656|B:ASP 659|B:ASP 664|B:GLU 657|B:LEU 660|B:LEU 661|B:LEU 663
|
9mib
|
K
|
N
|
C
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
|
NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYEHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
|
NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
|
NLWVTVYYGVPVWKDAETTLFCASDAKAYEHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSK[D][I]R[N][N][A][K][N]ILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSS[G][G][D][L]E[V][T]THSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIIN[M][W][Q][R]IGQAMYAPPIQGVIRCVSNITGLILT[R][D][G][G][S][T][D][S]TTETFR[P]SGG[D][M]RDNWRSELYKYKVVKIEPLGVAPTRCKRR
|
C:ALA 281|C:ARG 278|C:ARG 456|C:ARG 469|C:ASN 279|C:ASN 280|C:ASN 425|C:ASP 276|C:ASP 368|C:ASP 457|C:ASP 462|C:ASP 474|C:GLN 428|C:GLU 370|C:GLY 366|C:GLY 367|C:GLY 458|C:GLY 459|C:GLY 473|C:LYS 275|C:LYS 282|C:MET 426|C:SER 365|C:SER 460|C:THR 455|C:THR 461|C:TRP 427|C:VAL 371
|
9mib
|
O
|
Q
|
D
|
EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
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ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
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VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDLLALD
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EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
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EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV
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ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
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EVQLVETGGGLVQPGGSLKLSCRASGYTFSSFAMSWVRQAPGKGLEWVSLINRGGLTFYVDSVKGRFTISRDNSKNTLSLQMRDGDTAVYYCATGGMSSADFWGQGALVTV|ALTQPPSVSGSPGQSVTISCTGTSGSYNYVSWYQQHPGKAPKLMIYDVTQRPSGVSDRFSGSKSGNTASLTISGLQADDEADYYCSAYAGRQYIFGGGTRLTV
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VFLGFLGAAGSTMGAASMTLTVQARNLLSTVWGIKQLQARVLAVERYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLSEIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEK[N][E]Q[D][L][L]A[L][D]
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D:ASN 656|D:ASP 659|D:ASP 664|D:GLU 657|D:LEU 660|D:LEU 661|D:LEU 663
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9mib
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P
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R
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E
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QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
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NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
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NLWVTVYYGVPVWKDAETTLFCASDAKAYEHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSKDIRNNAKNILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSSGGDLEVTTHSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTDSTTETFRPSGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRR
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QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
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QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS
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NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
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QVQVVQSGAEVKKPGASVKVSCKASGYTFTDHYIHWVRQAPGQGLEWMGWINYRGGTNYAQKFQGRVTMTRDTSINTAYMELRFDDTAVYYCARPKDCSGDYWGQGTLVTVSS|NIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTHFTFTISRLQPEDIATYYCQVYETFGQGTKVEI
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NLWVTVYYGVPVWKDAETTLFCASDAKAYEHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTPLCVTLQCTNVTNNITDDMRGELKNCSFNMTTELRDKRQKVHALFYKLDIVPINSYRLINCNTAAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVMIRSK[D][I]R[N][N][A][K][N]ILVQFNTPVQINCTRPNNNTRKSIRIGPGQWFYATGDIGDIRQAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFANSS[G][G][D][L]E[V][T]THSFNCGGEFFYCDTSGLFNSTWISNDSITLPCRIKQIIN[M][W][Q][R]IGQAMYAPPIQGVIRCVSNITGLILT[R][D][G][G][S][T][D][S]TTETFR[P]SGG[D][M]RDNWRSELYKYKVVKIEPLGVAPTRCKRR
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E:ALA 281|E:ARG 278|E:ARG 456|E:ARG 469|E:ASN 279|E:ASN 280|E:ASN 425|E:ASP 276|E:ASP 368|E:ASP 457|E:ASP 462|E:ASP 474|E:GLN 428|E:GLU 370|E:GLY 366|E:GLY 367|E:GLY 458|E:GLY 459|E:GLY 473|E:LYS 275|E:LYS 282|E:MET 426|E:SER 365|E:SER 460|E:THR 455|E:THR 461|E:TRP 427|E:VAL 371
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8zh7
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B
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C
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A
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QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGNTNYNPSLKSRVTVSVDKSKNQFSLKLTSVTAADTAVYYCARDVSGGVNWFDPWGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
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NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSTVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT
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PKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQV
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QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGNTNYNPSLKSRVTVSVDKSKNQFSLKLTSVTAADTAVYYCARDVSGGVNWFDPWGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK|NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSTVVFGGGTKLTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT
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QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGNTNYNPSLKSRVTVSVDKSKNQFSLKLTSVTAADTAVYYCARDVSGGVNWFDPWGQGTLVTVSS
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NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSTVVFGGGTKLTVL
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QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGNTNYNPSLKSRVTVSVDKSKNQFSLKLTSVTAADTAVYYCARDVSGGVNWFDPWGQGTLVTVSS|NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSAPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSTVVFGGGTKLTVL
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PKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG[N]AL[R][Y]AP[D]GILGLQLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNL[Q][N][R][K][L][V]QVGIYNGTHVIPND[R][K][I][I]WPG[G]E[T]EKPRGYQV
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A:ARG 260|A:ARG 359|A:ARG 377|A:ASN 257|A:ASN 358|A:ASP 264|A:GLN 357|A:GLY 384|A:ILE 379|A:ILE 380|A:LEU 361|A:LYS 360|A:LYS 378|A:THR 386|A:TYR 261|A:VAL 362
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🦋 peleke-1 Training Data | SAbDab Antibody-Antigen Complex Sequences
A curated subset of SAbDab from June 2025 that includes antibody-antigen pairs of sequences.
Columns:
| Column Name | Description | Example |
|---|---|---|
| pdb_id | The PDB ID on Protein Data Bank | 8xa4 |
| h_chain_id | The chain ID of the antibody's heavy chain | C |
| l_chain_id | The chain ID of the antibody's light chain | D |
| antigen_ids | A |-delimited list of chain IDs of the antigen chain(s) | A|B |
| h_chain_seq | The heavy chain amino acid sequence | QLQLQESGPG… |
| l_chain_seq | The light chain amino acid sequence | EIVLTQSPGT… |
| antigen_seqs | The antigen sequence(s), |-delimited | SCNGL...|SCNGL… |
| antibody_seqs | The heavy and light chain sequences, |-delimited | QLQLQ...|EIVLT… |
| h_chain_fv_seq | The heavy chain sequence, trimmed to the Fv portion | QLQLQESGPG… |
| l_chain_fv_seq | The light chain sequence, trimmed to the Fv portion | EIVLTQSPGT… |
| antibody_fv_seqs | The heavy and light chain Fv sequences, |-delimited | QLQLQ...|EIVLT… |
| highlighted_epitope_seqs | The antigen sequence(s) with epitope residues encased in [ ] | ...WLI[D][Y]V[E][D][T]WGS… |
| epitope_residues | The list of epitope residues, |-delimited in a "chain: AA #" format | A:ARG 176|A:ASP 146|A:ASP 150… |
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Size of downloaded dataset files:
20.2 MB
Size of the auto-converted Parquet files:
7.58 MB
Number of rows:
9,523