Dataset Viewer
Entry
stringlengths 6
10
| EC_number
stringclasses 260
values | Active_site
stringlengths 0
544
| Sequence
stringlengths 20
2.05k
| labels
int16 1
260
|
|---|---|---|---|---|
A0A9R0IT30 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | NQLGAQTNVIAFLFLFFSSPLTLALQVGFYSKTCPNAETIVQQVVQQRFAADKSVAAALLRMHFHDCFVRGCDASILIDSTSTNQAEKASGANGSVREFALIDQIKAKLEQSCPQTVSCADIITLATRDSVALVGGPKYNVPTGRRDGLISKSNEVNVPGPSSTVSQAQQSFKIKGLTINDMVVLLGGHTVGITHCSFISDRLTNFQGTGAPDPTMNKTLLTQLKGTCGANPSADPSIFLDQKTPFVFDNEYYNQLKSNNGVLQIDQELAVDPLSSTLVNNMAANNAGFVQNFAKAMVKMGGIQVLQGTAGEIRTNCRVFNKN | 14 |
O64784 | 2.7.11.1 | ACT_SITE 623; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRIVACLLLITALFSSYGYAAITTSSPLSIGVTLSSPGGSYELGFFSSNNSGNQYVGIWFKKVTPRVIVWVANREKPVSSTMANLTISSNGSLILLDSKKDLVWSSGGDPTSNKCRAELLDTGNLVVVDNVTGNYLWQSFEHLGDTMLPLTSLMYDIPNNKKRVLTSWKSETDPSPGEFVAEITPQVPSQGLIRKGSSPYWRSGPWAGTRFTGIPEMDASYVNPLGMVQDEVNGTGVFAFCVLRNFNLSYIKLTPEGSLRITRNNGTDWIKHFEGPLTSCDLYGRCGPFGLCVRSGTPMCQCLKGFEPKSDEEWRSGNWSRGCVRRTNLSCQGNSSVETQGKDRDVFYHVSNIKPPDSYELASFSNEEQCHQGCLRNCSCTAFSYVSGIGCLVWNQELLDTVKFIGGGETLSLRLAHSELTGRKRIKIITVATLSLSVCLILVLVACGCWRYRVKQNGSSLVSKDNVEGAWKSDLQSQDVSGLNFFEIHDLQTATNNFSVLNKLGQGGFGTVYKGKLQDGKEIAVKRLTSSSVQGTEEFMNEIKLISKLQHRNLLRLLGCCIDGEEKLLVYEYMVNKSLDIFIFDLKKKLEIDWATRFNIIQGIARGLLYLHRDSFLRVVHRDLKVSNILLDEKMNPKISDFGLARLFHGNQHQDSTGSVVGTLGYMSPEYAWTGTFSEKSDIYSFGVLMLEIITGKEISSFSYGKDNKNLLSYAWDSWSENGGVNLLDQDLDDSDSVNSVEAGRCVHIGLLCVQHQAIDRPNIKQVMSMLTSTTDLPKPTQPMFVLETSDEDSSLSHSQRSNDLSSVDENKSSEELNASS | 99 |
W1PC58 | 3.1.1.11 | ACT_SITE 62; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGGFQNAAPKPAAGAQSQAVAMRISGDKAAFYNCRFYGYQDTLLDDKGRHFFKDCYIEGSVDFIFGSGRSLYRNCEIRSVSDYPGQTAIVAQGKSSKGDKSGFVFLDCHVTGMGDVYLSRAWREYSRVVFAYSYFDTVVNPEGWNDKGFTERDKTVFYGEYKCEGPGANTNRRVDYVKLLTDAQAKPFLDESFIRGRTWILPPPTL | 125 |
P21182 | 4.1.1.50 | ACT_SITE 29; /evidence="ECO:0000250"; ACT_SITE 32; /evidence="ECO:0000250"; ACT_SITE 88; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000269|PubMed:2266128"; ACT_SITE 102; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000250"; ACT_SITE 287; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000250"; ACT_SITE 301; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000250" | MTVTIKELTNHNYIDHELSATLDSTDAFEGPEKLLEIWFFPHKKSITTEKTLRNIGMDRWIEILKLVKCEVLSMKKTKELDAFLLSESSLFVFDHKLTMKTCGTTTTLFCLEKLFQIVEQELSWAFRTTQGGKYKPFKVFYSRRCFLFPCKQAAIHQNWADEVDYLNKFFDNGKSYSVGRNDKSNHWNLYVTETDRSTPKGKEYIEDDDETFEVLMTELDPECASKFVCGPEASTTALVEPNEDKGHNLGYQMTKNTRLDEIYVNSAQDSDLSFHHDAFAFTPCGYSSNMILAEKYYYTLHVTPEKGWSYASFESNIPVFDISQGKQDNLDVLLHILNVFQPREFSMTFFTKNYQNQSFQKLLSINESLPDYIKLDKIVYDLDDYHLFYMKLQKKI | 196 |
P94462 | 3.5.1.88 | ACT_SITE 133; /evidence="ECO:0000250" | MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDGVGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTRADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG | 183 |
A0A9R0HRH8 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTVQKVVSVFVILGTLFAMANAQGLKLNFYKSSCPKAEEIIKRVTEQYVSHVPNFAAGLIRMNFHDCAVRGCDASVLVEPTASNNQTEKTGVPNTTLRGFEVINAIKSAVEKECPGVVSCADILALASRDAIVTIDGPWWEVQTGRRDGKVSLASEANALIPSPFSDVNTLKQNFAALGLSAKDLVVLSGAHTIGIGHCFVIRNRLYNFTRVGDTDPTLSPRYAQHLKSRCPPTPTDVTSFVAMDHITPKVFDEKYYTMITQNRGLFTSDATLLDDNETRNYVLTQVQTMGSTFAKDFAVSMTKMINIGVLTGTQGEIRNTCGAVNS | 14 |
F6H6V9 | 3.1.1.11 | ACT_SITE 421; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MGYNNAADADSRGKKKVALMGFSSILLVAMVVGTVVTVNHRNGSSSSATDDAQAGGGISTSVKAIQAICQPTDYKEACVNSLTSAKANTSDPKELVRTAFQVAINQISSALQNSTTLRDLEKDPRTKGALENCHELMDYAIDDLRNSFNKLGVFDISKIDDYVEDLKIWLSGALTYQETCLDGFENTTGDAGEKMKALLKSAGELTSNGLAMIDEISSVLTNLQIPGISRRLLSDESGKGEYRSDEGGLYPSWASVGQRKLFQATPDTIKPNVIVAQDGSGKYKTINEALVEIPKNGNTTFVLYVKEGVYKEQVNFTKSMTNVMLIGDGPTKTTISGSLNFIDGIGTFRTATVAAVGSNFMAKDIGFENNAGASKHQAVALRVGSDMAIFYNCRMDGYQDTLYVHAHRQFYRDCTITGTIDFIFGDSAVVFQNCLILVRKPLDNQQCIVTAQGRNERREPTGIVLQNCTISAADDYIPFKTKFKSYLGRPWKAFSRTIIMQSQIDDLISPEGWLPWMGDFGLNTCFYAEYGNRGPASATTSRVTWRGIKQITGQHVNDFTVGRFISGHLWLGASGVPYTSDMMAV | 125 |
A0A072UAE2 | 1.11.1.7 | ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKNSASITSFYSFLLISSILFASYFHASKAQTNAPPAVKGLSYGFFAQTCPNLENIVRKHLTKVFKSDNGQAPGLLRIFFHDCFVQGCDGSVLLDGKPGERDQPQNGGMRTEALKTIDDIRALVHKECGRIVSCADITVLAGREAVFLSGGPNFPVPLGRKDGTSFSIKGTSNLPQPFNKTDVTLKVFAAQNFDVTDVVALSGAHTFGRAHCGTFFNRLSPADPTLDKTLAQNLKNTCPNANSGNTANLDIRTPATFDNKYYLDLMNKQGLFTSDQDLNIDSRTKGLVNDFAVNQGLFFEKFVNAFIKVSQLNVLVGNQGEIRGKCNVVNGGKKSVLSTLVEEGMDLIEQF | 14 |
Q8Y8D7 | 2.7.1.23 | ACT_SITE 45; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:17686780" | MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED | 89 |
A0A2R6XN30 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAGARVKAFAILCMVALCLHMADAQVRGLRVNYYQRSCPRAEQIIRTAVQNGFNSDPTIPAGLIRMLFHDCFVRGCDASVLLDNADSEKLGAPNANSLRGFEVLDAAKSALEAACPGVVSCADVIAYAARDAMEVAGTVKVPNWLGGRKDGSTSVSAETLTELPAPFSNFTTLQRAFERKGLNQADLVILSGAHTIGIARCGIILQRIYNFKGTGQADPAINPAYVQTLRNLCPSNAPGKQINMEMLTPTKIDANYFNDVQAGRGLFESDNALRTTPIGRSLVSVYRVPQVFNAAFVASMRKMASIGVLTGSNGKIRTKCNIA | 14 |
P53974 | 2.7.11.1 | ACT_SITE 159; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNQPQIGTYNVGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPPDPHSNSSVACLKRVIVPDKPSLNTLRAEVDAMRLLKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQVTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRPPRNSQELSYVQQDILKNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNYSEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQNILSLNSPTTMENTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGSQPLFDKSQNMYHALDPPLVEPLASSVSNNDNELKANSATKLKQAIVSEAHTFRQNNSIDFPLQNIIPQYEDSSSSSDESYSGDVDELKKTRSLGSYSTRGNIKKNQSVKESLTSSSLPGTSFTPTSTKVNLKHENSPFKSTFVNTIDNSKDDLNKPSYEDLDVSKQNLKNSIQQRMIDKLNSSEESFNARKMSKVKLHEKGEIDKPTMLKSSGPISKDKKTKPTPPPKPSHLKPKPPPKPLLLAGRKLSLDK | 99 |
A7RSL3 | 3.1.3.1 | ACT_SITE 114; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MIRVDTLLVFAFCLVVLTALCSGDVPASQSNNQWFKDGVSTVKKHLLQRPNTKPAKNLIIFVGDGCDINTNTAGRILKGQLKGQVGEKGWLSYEEFPYTGLSKTYTTNRQGSDSAGTANAMFTGVKTRSAMIGVNEEVVTNKCETLTEDRKVDSILKLAEEAGMATGFITSMRLTHATPANLYAHSASRYWESDKEMVSRGYGNTSCKDMAQQLVDFQGSVGDGIEVVMGGGRRSFLPNTTRDPEHVNKTGERYDGRNLIQEWLNKREGSVYAWNKTQFDAVDPKTTKHFLGMFESSHMQFAIDRDEDVGGEPSIAEMVEKAVSILKNNDNGKGFFLAVEAGLIDIGHHNGIARQALNEVVNLEEGVAKAVEMTDKEDTLIISTADHGHVFTLTGYPDINSPIFGLMKQDGEVKLALNDNKPYTILGYMNGPGAVKGVRANLTGVDTGAKDFKQQALYIGYDYDEAHGSQDVGIYSRGPWAHLLTGVVEQNVIFHVMDHALCLSSSKQGTCSKPEARGGPSASAAMVTALFAPLVAALVTCLVLY | 141 |
Q89WR7 | 3.4.21.92 | ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00444"; ACT_SITE 127; /evidence="ECO:0000255|HAMAP-Rule:MF_00444" | MRDMLQLVPMVVEQSARGERSFDIYSRLLRERIIFLNGEVNDAMSGLVCAQLLFLEAENPNRPINLYINSYGGVVTSGLAMYDTMQFIKAPVHTLCMGTARSMGSFLLMAGERGHRAALPNASLHVHQPLGGFQGQASDILIHANEMQETKRRITRLYAQHCGRTEAEVERTLDRDHFMTAQQGVEWGLIDRVFAERDAT | 179 |
A0A0A0KWM1 | 3.1.1.11 | ACT_SITE 229; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSRPLIFNLFFLLIAIILPAAAQNWTAGGGRGMRSTVQDEYFKWIRHMGSFKHSLFQNTKNKFKPCLTLKVSKNTKAGGFRSLQKAVNSLPIINRCRVRIHVAAGIYREKVEIPATMSYIWVEGEGAEKTIIEWGDTADHMGENGRPMGTFASATFAVNSPFFIATNITFKNKARLPPSGALGKQAVAFRISGDAAAFISCRFIGAQDTLYDHMGRHYFKDCYIEGSVDFVFGDGLSIYDSCHLHAITNSYGALTAQKRNSMLEETGFSFLHCKVSGSGALYLGRAWGSFSRVVFAYTFMDKIITPTGWYNWGDKNRELTVFYGQYRCSGPGADYGGRVPWSRELTQSEANPFLSLDFINANQWLPNYHTHLSLKPH | 125 |
G1KG45 | 3.1.3.48 | ACT_SITE 836; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000927-1" | MNNRLRALGGRINNIRASELPKERIRSDIVCNVHFLDGSLQSFKVNKQDTGQVLLDLTFNHMGVTEKEYFGLQHCEESAVSPRWLESDKPIRKQLKGGSSCSLYFRVRFFMPDPNTLQQEKIRHLFFLQLKADILEGRLLCPVNSAVVLASYAVQSQLGDYSASTHLPGYLSDYCFIPEQNKDFLTKVESLHEQHSGLKQSEAESCYINIARTLEFYGVELHSGRDLHNLDLMIGIASGGIAIYRKLICTSFYPWVNIIKISFKRKKFFFQQRQKPSESREHIVAFNMLNYRACKNLWKSCVELHTFFQAKKMLPHEKKLQSHFWTMGSRTPTKSNNQCCRKVIGGMIWNPALRRSLSVEHLETKSLPSRSPPVTPNWRSPRLRHEIRKPKHSSVDNLANEISYITETEDVFYTYKDSSASKDSDSVLCQNLQQRNILENNSAQKSSPQTSNEVSSLQGSHPLGGRDKQFPETNENLAKGLLMDDSNQYYFDKNDVIDGDLLLIHILPDEDGKFGFNLKGGIDQKMPLVVSRIMPGSPSDKCAPKLLEGDQIVLINGRDISEHTHDQVVMFIKASRESHTRELVLLVRRKVIKPFAENKSEDETDSFNFPETILPACSEYGQTLEESMEQLKKGLESGTILIKFEQLYRKKPGLAITCAKLPQNMDKNRYKDVLPYDITRVVLRGEENYINANYVNMEIYSTGIVNKYIATQGPLSHTCVHFWQAVWDHKLSLIIMLTTLTERGRTKCHPYWPDPPDIVEFGNFRIKCRTEDCTIAYVFREILITNIETEEEHTVTHLQYVAWPDHGVPDDSTAFLEFVTYMRPKRIENEPVLVHCSAGIGRTGVLVAMETAMCLIERNQPVYPLDIVRKMRDHRPMMVQTSSQYKFVCEAILHVYKEGIVRPLDSR | 149 |
O31801 | 3.6.1.23 | ACT_SITE 82; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:20823546, ECO:0000305|PubMed:23897460" | MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLVPLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDTEIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK | 189 |
Q5KKV0 | 4.6.1.16 | ACT_SITE 249; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 257; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 288; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MSPPPHSIPLYLVNGVATVWDAQTAATLHCVHNVSGLRAGTLPGVAQQNGFLGLPLTLMQEETAYLVTQGIAHLVPLDPSPSPPSDETVKAHTAARVARLKALEEKTREAEAKRLEESKKAFDKGGEKARLKREARARAKAEKAKESGEGLFAEDVKENVTAPIVVSPAKTKTKHAGAPAAGHFHIVPSHPVLSQHPPESQSITSLPHPLFPFPTTPRQCALLGVFSKLQSLSYRVGLGPRFGGEWLIYPGDYLRYHAHFTSQVIVRDEPIRPTEIVAWGRLGTGTKKAGLICCWDDGKREDGQDDQGGKEEDVEFYSLEWANFG | 207 |
Q8IUH4 | 2.3.1.225 | ACT_SITE 456; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067" | MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMVFHPAREKVLRSV | 57 |
A0A067DRC2 | 6.3.4.4 | ACT_SITE 77; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 105; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03125"; ACT_SITE 205; /evidence="ECO:0000256|PROSITE-ProRule:PRU10134" | MNISSVKFNHAGPITGPKWAGFRPTLHLRRNSDVVSFESRTKAGAAPSSLAVTANELPSQIESLSQVSGVLGSQWGDEGKGKLVDILAEHFDIVARCQGGANAGHTIYNAEGKKFALHLVPSGILNEDTVCVIGNGVVVHLPGLFNEIDGLEANGVSCKGRILVSDRAHLLFDFHQEIDGLREAELAKSFIGTTRRGIGPAYSSKVIRNGIRVCDLRHMDTFPQKLDLLLSDAAARFPGLKYTPDVLREEVEKYKRFAERLEPFITDTVHFMNESIAQKRKILVEGGQATMLDIDFGTYPFVTSSSPSAGGICTGLGIAPRVVGDLIGVVKAYTTRVGSGPFPTEIFGQGGDRLRLAGQEFGTTTGRPRRCGWLDVVALKYCCQINGLSSLNLTKLDVLSELPEIQLGVAYKQFDGTPVKSFPADLLLLEQLKVEYEVLPGWQSDISSVRNYSDLPKGAREFVERIEELVGVPINYIGVGPGRDALIYK | 253 |
C5CPN2 | 2.2.1.2 | ACT_SITE 126; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MNQLDALRQWTTVVADTGDFKQLAISRPQDATTNPSLILKAVQKPEYRPLLDEAVSKHAGKPLDEVIDRLLVRFGTEILSIIPGRVSTEVDARLSFDTAATVARGERIVALYKAEGIDTEKRLLIKVASTWEGIEAARTLEQKGIRTNLTLLFSFAQAVACGAAGVQLISPFVGRIYDWYKKSAGAQWNEAASAGANDPGVKSVRQIFEYYKQHGIKTEVMGASFRNVGQIRALAGCDLLTISPELLAELAASNEPLAHALDAKAATGGDVAKVSYDEAGFRFALNEDAMATEKLAEGIRAFAADAVKLEKLMQESGK | 52 |
A0A2C9WFA8 | 3.1.1.11 | ACT_SITE 442; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKPLNYGRLGPSEPGGSSRSLDQSQFTNSHPSPSRKRKVILLSLLSAALIIASAVSATLLIGLRTRASDHSTPVVARKPTKAISKTCSKTRFPTLCVNSLLDFPGSTTASEKDLVHISFNMTLQHFTKALYLSSGISYLQMDTRVRSAYDDCLELLDDSVDALSRSLSIVAPSMDGNPAGQVQSIGSTEDVVTWLSAALTNHDTCTEGFTDLNGAVKDQMSDKLKDLSELVSNCLAIFSGTDSDDFSGVPIQNRRRLMDAEISKENADDLPSWLGRNERRLLNVPVSAIQADIIVSNDGNGTYKTIAEAIKKAPEYSNRRTIIYVRAGRYEENNLKVGRKKRNLMFIGDGKGKTVISGSKSIFDNVTTFHTASFAATGAGFIARDMTFENWAGPAKHQAVALRVGADHAVVYRCNIIGYQDTLYVHSNRQFFRECDIYGTVDFIFGNAAVVFQNCSIHARKPMAFQKNTITAQNRKDPNQNTGISIHACRLYATPELEAAKASFPTYLGRPWKLYSRTVYMLTYMGDHIHPRGWLEWNATFALDTLYYGEYMNYGPGGAVGQRVKWPGYRVITSTVEASKFTVAQFIYGSSWLPSTGVAFLAGLSV | 125 |
A0A059BA15 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDLELSRVLALLAYCCLMGTGNAQLRFGFYGQTCPSAEPIVRSVVRNAVISNPNMAAILLRLHFHDCFVEGCDGSILIENGRSAERNAFGHQGVGGFEVIEEAKKHLEVTCPGVVSCADIVALAARDAVAMANGPDYEVPTGRRDGRVSNVSLAEDMPDVGNSIQQLKSKFFQKGLTEKDLVLLSAAHTIGTTACFFMTDRLYNFMPGGGSDPSINPDFLPELKSMCPQNGDVNVRMPIDHGSEQTFDDQILRNIRSGWAILESDAKLNDDPVTRSVIESYVGLFNPIFGPSFEAEFVESMVKMGQIGVKTRVKWRDQAGLQIF | 14 |
A0A1Y1HPL7 | 2.3.1.181 | ACT_SITE 137; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MAHKALQIMRLGRIPYGAGLRIQETLFSLRTQKSVPDTLLALEHPPVYTVILYPILNLHEAKIGARAYVEGLEEVMVQTAGVWGVKARGKVPAETGVWVEDRKIGAVGVRISRGVTSHGLALNATVDLGWFEHIVPCGIADKEVTSLERETGGAEVRFDDVMRESMRAFCRVFGYQHP | 55 |
B8E1X9 | 3.2.1.21 | ACT_SITE 324; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055" | MVKYKFPEGFLWGTATASHQIEGDNFYNDWWEFEKQGKVKNGQVSGKACDSWNRYEEDFDLIEKLNNNAYRFSIEWSRIEPEEGRFDESALERYRSMLISLRRRNIEPFVTLHHFTNPLWMAKRGGWLNPDIIDYYLRYVKKIVSEFKDLVNYWMTINEPNAYAFMAYLYGQFPPQGKSLIKMLRVLNNMAKAHAKAYEVIHQISPDAKVSIAYNVIYFEPKNPNSFIDRKFANFGDRIYNRVFIETLLTGKFSSPFIKEEIPYAKNTLDYLGINYYTRILMGLKMGSPEGETSDFGWEIYPEGIYKVVKRFYGLTKKPIYITENGISDAKDEKRPKYLISHLIQLHRAIEEGVDVRGYFHWSLMDNFEWAEGFLQRFGLFETDFNTFERKWRESARIYSEIAKNNGITEAMEEKFLK | 161 |
F0ZP93 | 3.1.3.48 | ACT_SITE 86; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MNDVSKIFPGFYIGSLPAVNRGNLDKHQITHILSILNEFRPKWTNMYSYLHIDIYDSPSVDIKKYFEKTFQFIEEGRREGAVLVHCFAGISRSATICIAYCMRKLRISFEDAHGLLFDARPIIFPNESFVKQLKKYEAELKEGIIVPISTNLRFKLYSPKYDSDDDESEEDEDDGYDTEEEYEDEEDEESEEEEEEEEEYDNVVKKDKKVNQKATVEQTTASISNISISSSSSSPSSENNDINNNSDNINNTQEETEEESNNNKATLGVYRYCCRKCSTELFLDYDILDHEQGEGQSSFKFHRRDLNLSENKEAAAKKVVCTSFFISEIEFVLNQTGEGMSGKLNCLNCKEKLGSWSWSGEQCSCGQWIAPSFQIPKQRIDEKRITKKN | 149 |
Q5Z6B1 | 4.6.1.16 | ACT_SITE 157; /evidence="ECO:0000250"; ACT_SITE 165; /evidence="ECO:0000250"; ACT_SITE 204; /evidence="ECO:0000250" | MDLPGPRWKKGKDGKDFASLAAANPMSAIVSELKASFISSKPVAILSGPGGSAVLGVGPEQAVILNRAAFGHAIENATAQKHWFQLSPEEVFYLCHALNCIRVDSLDNKQMSEIELWDYFRSGSESFPEMYKAYAHLRLKNWVVRSGLQYGADFVAYRHHPALVHSEFAVVVVPEGAEFGNRCGRLEVWSDLLCALRASGSVAKTLLVLTISSSSKCELSSPDCLEQLVVHERTITRWILQQCREQRCEPSRDEVNREELIIEKESVVFNHWGVILGFTVLSGLLVYRLKFRQ | 207 |
K7M080 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MPLARERENHQISSLKLARYFLFVCMKMDAILGSLMILVMTSAVQAQLKTGFYSTSCPNAEAIVRSTVVSHFSKDLSIAPGLLRLHFHDCFVQGCDGSILIADSSAEKNALPNIGLRGFEVIDDAKSQIEAICPGIVSCADILALAARDAVDLSDGPSWPVPTGRRDGRISLSSQASNMPSPLDSVSVQRQKFAAKGLDDHDLVTLVGAHTIGQTECRFFSYRLYNFTTSGSADPTINVAFLAQLQALCPKNGDGLRRVALDKDSPAKFDVSFFKNVRDGNGVLESDQRLWEDSATQSVVQNYAGNVRGFLGLRFDFEFPKAMIKLSSVEVKIGTDGEIRKVCSKFN | 14 |
A5PJC4 | 2.3.2.23 | ACT_SITE 86; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MTASKRVAKELEDLQKELPKYLRNLCSEEDNVLVWHALLLPERPPYNLKAFRLCISFPREYPFQPPTVKFTTRIYHPNVDRDGRVCLPIISKKNWKASTRTCQVLEALNMLVNQPEPGQPVRLELAEQLTQDPELFDQMAQEFTLQFGVDRPS | 64 |
Q95PZ9 | 2.7.11.1 | ACT_SITE 147; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MSEQRDSRGMPQAGFIIEHQSSDHKWKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNSRPVLKLDVMVLMATKGLRGFPNFVAAGRTDVYRYCIMQLVGPDLGRLRRTRPERKFSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGENESTVYILDFGFARKFVDKEGKIIPPRTAAALMGTFQYCAVSAHSHKDQCARDDLESWFYMGIELLKGPLPWANIDGHKNHKQIGEAKVAIRSEPLRSEFFEGVPKQFNEILTILDQTSYFDRPNYKKLGDLLSQAATEHQVTLKEPLDWQNNERMQQKAIFVGELGESHQASAKLDAKDNANESMDIEFDDMPPKEGISKSLSAEKSCTKNVETARTEK | 99 |
D4ZX35 | 2.1.1.37 | ACT_SITE 93; /evidence="ECO:0000255|PROSITE-ProRule:PRU01016, ECO:0000255|PROSITE-ProRule:PRU10018" | MSNRLSYWEYLHQELKLNADIQSQLVVLDLFAGCGGFSLGFKAAGFQTIGYEMLADAAATYTRNLQDPCYCQTLEIGQDLCNHPDVIIGGPPCQPFSVGGLQKGPRDSRDGLPIFIDAIARYQPEIAIFENVRGMLYKNRQYLEKIVAELERLNYRVDIKLINAVNYGVPQKRERLFVVAYQTAWNWPEAETLAIPYTAGDAIYDTASTIPIGAKFLTPSMLEYIGRYEAKSKCVKPRDIYLDIPCRTLTCRNLSGATSDMLRLLLPDGRRRRLTVREAARLQSFPDWFELVGSENSQFNQIGNAVPPLLAKAIAKSVKMTLENKPSRPTDYFSPFPQQLKLPFA | 47 |
Q9KRX4 | 2.3.1.286 | ACT_SITE 112; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121" | MSLPYRHVVILTGAGISAESGIQTFRAQDGLWENHRIEDVATPEGFQRDPDMVLEFYNQRRRKLLSDAIQPNPAHLALGKLEKELQGSVTVITQNIDNLHERGGSQNIIHMHGELLKARCPESNQTVEQKEDIRHGDLCHCCQMPAQMRPHIVWFGEMPLRMGDIYAALEQADLFVSIGTSGVVYPAAGFVHDARMHGAHTIEINLEPSAVESEFAEKRYGKASIEVPRLVEEILAAQARAKESAA | 58 |
A0A9R1VIC6 | 3.1.1.11 | ACT_SITE 377; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSFFRFLLLILFLSTHQTLSRSSPDSASLIRSVCKSTPYPDVCFDSLKLSISININVNVVLQSLQFAINEGVKLLPFLSNTDGNIIEKQKGTIQDCNELHQITLSSLKKSLSRLTTTSSSSSSNKLADAGAFLSAAVTNKNTCLEGLESASGPLKPLLVDTITTAYKHVSNSLSLLSASSSKEKDKSKHHKTTNKGMDLPKWLSGKDRKIFRNDYEDDNDDYDYDYNTLTVANDGSGNFTTITDAINFAPNNSVDRVLIYIKQGLYEENVEIPSYKTNIVLLGEGSDITTISGNRSVIDGWTTFRSATVAVSGEGFLARDIGFHNIAGPEKHQAVALRVNADLAAVYRCAISGYQDTLYVHSFRQFYRECDIYGTIDYIFGNAAVVFQGCNIISRMPMPSQFTVIAAQSRDSPDQQTGISFQNCSILATDDLRDRSSFVTNSTSIPAVKSYLGRPWRTYSRTVFMESYIDNLIDPMGWIHWSSKDEGLESLYYGEYGNIGPGSRVEGRVSWPGYHVMDYNEATNFTVTEFIAGEEWLDSTSFPYDDWV | 125 |
Q86UX6 | 2.7.11.1 | ACT_SITE 216; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:Q60592, ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRSGAERRGSSAAASPGSPPPGRARPAGSDAPSALPPPAAGQPRARDSGDVRSQPRPLFQWSKWKKRMGSSMSAATARRPVFDDKEDVNFDHFQILRAIGKGSFGKVCIVQKRDTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIATIIKDGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLVQLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRLSSLQDVQAAPALAGVLWDHLSEKRVEPGFVPNKGRLHCDPTFELEEMILESRPLHKKKKRLAKNKSRDNSRDSSQSENDYLQDCLDAIQQDFVIFNREKLKRSQDLPREPLPAPESRDAAEPVEDEAERSALPMCGPICPSAGSG | 99 |
A0A3B3HKM1 | 2.7.11.13 | ACT_SITE 506; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MTLSPCPYHHVFVHLWKQVILGPVTMAPFLRIAFNSYDLGILPPSADKPFCAIKIKEALTTDRGKTLIQKKPTMYPAWKACFDAHIYEGRVLELLLMRTADEALAEVSVGVSVLAERCKKANGRAEFWVDLQPSGKVMMAVQYFLEDVDAESKQAVKEEEAPTLNRRRGAIKQAKIHFIKNHEFIATFFRQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTVFQKERFKIDMPHRFKTNNYMSPTFCDHCGSLLWGLVKQGLKCEDCAMNVHHKCQKKVANLCGINQKLLAEALTQVSQKSSTRRSDPNLPPMPDIGIYDEVNKLAGLELNDASPYGRLWEGCSPRPQSRITHLTRINVDNFIFHKVLGKGSFGKVLLAELKGSGEYFAVKALKKEVVLMDDDVECTMVEKRVLALAWENPFLTHLYSTFQTKEHLFFVMEYLNGGDLMFHIQEKGRFDLNRATFYSAEIVCGLEFLHSKGIIYRDLKLDNVMLNHEGHIKIADFGMCKEDVFGDNRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVLLYEMLVGQSPFHGDDEDELFESIRMDTPHYPRWINKEAKDLLEQLFDREPTHRLGVVGNIRQHSFFKTINWQALERREVEPPFKPKVKAPNDCSNFDREFLSEKPRLSQSDKNFIDSMDQSAFSGFSFINPKMERLLEN | 100 |
Q7NND8 | 2.7.1.23 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MPAFETVVIAYRAEEAHSRIAADRCESLLHKVGCRVLKGPTGPQDNPYPHFLEATGGHIDLAIVLGGDGSILAAARYLAAVDVPILAVNVGGHLGFLTQPPEVLGGRYWERLLAGEWELEKRMMLQASLTGPPPLPERQPYFCLNEFCLKPASEMRLTSIILELAIDGEIIDQIHGDGLLVSTPTGSTSYTVAANGPIIAPSLQAITITPICPLSLSSRPVVLPATGTIEVSPLRDPDLNIKLWSDGAFAAPVHPCQTVRIEVARHPTRLLILEEDHSYFRTLREKLKWAGTRIQAERDPECLLPPQNHP | 89 |
A8IAN1 | 2.2.1.1 | ACT_SITE 463; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MQTMLKQRCQPAVGKQAKAVPAVAPKVGRARNVVVAQAAPAAAKAAAPSISRDEVEKCINAIRFLAIDAINKSKSGHPGMPMGCAPMGYVLWNEVMKYNPKNPDFFNRDRFVLSAGHGSMFQYSMMHLTGYDSVPLDQIKQFRQWNSLTPGHPENFVTPGVEVTTGPLGQGICNAVGLAVAEAHLAARFNKPDVKPIVDHYTYCILGDGCMMEGISNEACSLAGHWGLGKLIALYDDNKISIDGHTDISFTEDVAKRYEALGWHVIHVINGNTDVDGLRAAIAQAKAVKDKPTLIKVSTLIGYGSPNKADSHDVHGAPLGPDETAATRKNLNWPYGEFEVPQDVYDVFRGAIKRGAEEEANWHKACAEYKAKYPKEWAEFEALTSCKLPENWEAALPHFKPEDKGLATRQHSQTMINALAPALPGLIGGSADLAPSNLTLMKISGDFQKGSYAERNLRFGVREHAMGAICNGIALHKSGLIPYCATFYIFTDYMRNAMRMSALSEAGVVYVMTHDSIGLGEDGPTHQPIEHLASFRAMPDMLMIRPAGGNETAGAYKVAIANRKRPTTIALSRQNMPNIPNCSVEGVAKGAYTIHDTKAGVKPDVILMGTGSELELATAAAGILEKEGKNVRVVSFPCWELFEEQSAEYKESVLPSDVTARVSVEAATSFGWAKYIGLKGKHVGIDTFGASAPAPTLYEKFGITVNHVVEAAKATLQH | 51 |
Q55G11 | 3.5.1.23 | ACT_SITE 298; /note="Nucleophile"; /evidence="ECO:0000250" | MINSFKKLIILISLVIILLSSNNIFIDSFKIPVNQKNVKSSGDSSYQIGAGIYDITGASAEVNLMGYANPLQVGAGIHFRQRARAFVFVDSNGNRAVYVSTDSCMIFQEVKIHVVELLQDIFGPNVYTEANVLLSGTHTHSGPAGFSQYALYGITSLGFYKKNFDTICNGIVQAIVKAHKSVQPANMFTETGELWNTNINRSPFAYDNNPEEEKAMYDSNVDKNMTVLRIEDMNGNPFAAISFFAVHCTSMNNTNHLISGDNKGYASYLWEKQVNGPGTAGKGPFVAAFGQSNEGDVSPNTRGPTCRDGSPCDYKTSTCNGRNEECWSLGPGKDGDMFESTQIIGGNQFNKALELFNNASIQVSGPVQYRHSWVQFTNVSVEPPYNSGVDNATTCRGAMGYSFAAGTTDGPGAFNFVQSDNNTSGNPFWNFIGDFIAKPTPDQIRCQSPKPILLDVGMVEPIPWVPDVMPIQIVTIGQIVLVAVPGEFTTMSGRRLRNSVREIIGESIENPIVLIAGLSNTYSGYIATFEEYQVQRYEGASTVFGPHTLGSYMQEFGKLAQSIVDGTTVPAGPTPRNLTGHTLFFLPPVIVDAAPDFDDFGEVSIDVNLNYSVNETVSCVFYGGNPRNDFMIESSFLSVDLLTGTDQWTTVLDDGDWDTKFKWKMHDLGFSLITIEWVIAPDTTPGTYRITHSGFAKKNPFSSNLTPYQGISRNFVVQ | 182 |
Q9Z0L8 | 3.4.19.9 | ACT_SITE 133; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607"; ACT_SITE 243; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00607" | MANLGYLLCLLGLLLCGLSSPGMSRPYNHGSERPIIGVVMQECFGKMAKLGNYYIAASYVKYIESAGARVVPIRPDLSDAEYEELFRSINGVLLPGGGANLTDSGYSRVAKIFFSKALESFDNGDHFPVWGTCLGFEELSVLVSGENLLTSTDTKSKKLPLNFTEGARKSRMFKHFPTELLDSLALENLTANFHKWSLSVKNFTENEKLKKFFNILTTNTDGKTEFISSMEGFKYPVYAVQWHPEKAAFEWKNLGGISHAPNAVKTSFYLAEFLVSEARKNSHHFENVVKETASLIYKFNPIYTGNISSFQQAYMFD | 176 |
Q55535 | 3.1.3.48 | ACT_SITE 7; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 13; /evidence="ECO:0000250|UniProtKB:P11064"; ACT_SITE 124; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P11064" | MKLLFVCLGNICRSPAAENIMNAQIDQAGLGAKIVCDSAGTSSYHVGDSPDRRMTESLKKRGYRVQGRARQFFPEDFAEFDLILAMDGDNYRNILAQDPAGQYHHKVKMICDYTEKFGDREVPDPYYGGQAGFEHVIDLLEDACGNLLTSLGKELVN | 149 |
O81832 | 2.7.11.1 | ACT_SITE 590; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEATNVLHLLIISLFSTILLAQATDILIANQTLKDGDTIVSQGGSFEVGFFSPGGSRNRYLGIWYKKISLQTVVWVANRDSPLYDLSGTLKVSENGSLCLFNDRNHIIWSSSSSPSSQKASLRNPIVQILDTGNLVVRNSGDDQDYIWQSLDYPGDMFLPGMKYGLNFVTGLNRFLTSWRAIDDPSTGNYTNKMDPNGVPQFFLKKNSVVVFRTGPWNGLRFTGMPNLKPNPIYRYEYVFTEEEVYYTYKLENPSVLTRMQLNPNGALQRYTWVDNLQSWNFYLSAMMDSCDQYTLCGSYGSCNINESPACRCLKGFVAKTPQAWVAGDWSEGCVRRVKLDCGKGEDGFLKISKLKLPDTRTSWYDKNMDLNECKKVCLRNCTCSAYSPFDIRDGGKGCILWFGDLIDIREYNENGQDLYVRLASSEIETLQRESSRVSSRKQEEEDLELPFLDLDTVSEATSGFSAGNKLGQGGFGPVYKGTLACGQEVAVKRLSRTSRQGVEEFKNEIKLIAKLQHRNLVKILGYCVDEEERMLIYEYQPNKSLDSFIFDKERRRELDWPKRVEIIKGIARGMLYLHEDSRLRIIHRDLKASNVLLDSDMNAKISDFGLARTLGGDETEANTTRVVGTYGYMSPEYQIDGYFSLKSDVFSFGVLVLEIVSGRRNRGFRNEEHKLNLLGHAWRQFLEDKAYEIIDEAVNESCTDISEVLRVIHIGLLCVQQDPKDRPNMSVVVLMLSSEMLLLDPRQPGFFNERNLLFSDTVSINLEIPSNNFQTMSVIDPR | 99 |
Q8L7U5 | 3.1.3.16 | ACT_SITE 651; /note="Proton donor"; /evidence="ECO:0000250" | MGSKPWLHPAPQYKTLETFWDDEDDAPGPRCAHTLTAVAATKTHGPRLILFGGATAIEGGSSSVPGIRLAGVTNTVHSYDILTRKWTRLKPAGEPPSPRAAHAAAAVGTMVVFQGGIGPAGHSTDDLYVLDMTNDKFKWHRVVVQGDGPGPRYGHVMDLVSQRYLVTVTGNDGKRALSDAWALDTAQKPYVWQRLNPDGDRPSARMYASGSARSDGMFLLCGGRDTLGAPLGDAYGLLMHRNGQWEWTLAPGVAPSPRYQHAAVFVGARLHVSGGVLRGGRVIDAEASVAVLDTAAGVWLDRNGQVTSARGSKGQIDQDPSFELMRRCRHGAASVGIRIYVHGGLRGDVLLDDFLVAENSTFQSDISSPLLASDRTQQSSTPRFSYAARPPSGSEPSFSMSEGLSLDENSLEKLTEASAAEAEVASSVWRAAQLGAGTLDEEPSTSDASSPIVESTTDGTANEGDVRLHPRAVVVAKETVGSLGGMVRQLSLDQFQNESRRMVPMNNSDVPQPTKKFTRQKSPQGLHKKVIAALLRPRNWKPPGNRKFFLDSYEVGELCYAAEQIFMHEQTVLQLKAPIKVFGDLHGQFGDLMRLFDEYGFPSTAGDITYIDYLFLGDYVDRGQHSLETITLLLALKIEYPENVHLIRGNHEAADINALFGFRLECIERMGENDGIWAWTRFNQLFNYLPLAALIENKIICMHGGIGRSISTVEQIEKIERPITMDAGSLVLMDLLWSDPTENDSIEGLRPNARGPGLVTFGPDRVTEFCKRNKLQLIIRAHECVMDGFERFAQGQLITLFSATNYCGTANNAGAILVVGRGLVIVPKLIHPLPPPILSPENSPEHSGDDAWMQELNIQRPPTPTRGRPQPDFDRSSLAYI | 144 |
A0A1D6IKW0 | 1.11.1.7 | ACT_SITE 118; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MATKLAVLATLVLALLGPVSCQQQQAGYGYGAGSPTPTSSPPPPAAYPPMTTSPTPSSPTAYPPPPPPTPSPPPPAAGAGLSVGYYKDKCAEAETIVQEAVRAADAGTKAGLVRLFFHDCFVQGCDASVLLKPDNDTNPQPEMLGVPNLSLRGFEVIDAAKAAVEARCPGVVSCADIVAFAGRDASAFLSGGAINFTMPAGRYDGTVSLANETLPNLPPPFADVRRLKAMFAAKGLDTVDMVALSGAHSIGRSHCSSFSSDRLPPSNTSDMDPAFAATLQASCASSANGAADNTVVQDYRTPDQLDNQYYRNVISHKVLFASDAALLKSSDTLGLVYVAAFSQKLWQDKFGQAMVKMGGVQVKTAANGEIRRMCGYVNKP | 14 |
O25849 | 2.3.1.286 | ACT_SITE 104; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_01121" | MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESAVHAMQDLMPKLIEMAS | 58 |
A0A2K1KP88 | 1.11.1.7 | ACT_SITE 123; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MISRNAEAKKIRTKRGGVSKFASAWECSFNGRRKVLQVGAPDAAPPQQLEAPSPSAPSSPPLPPQSTVATRPTGADVHGEPPLDYDFYTKSCPSFQQIVKTQVARAILADSLTPAKLLRLFFHDCFVMGCDASLLLNSTVVNLAERDHANNFTVDKYSVIDSIKAELEKACQAIVSCADTLGAAAAEAVEQAGGPHVDLAYGRRDGLESFAPAAKTNLPAGTLQVAGLLENFQNVGLNLTDVVVLSGGHTIGQARCSSFADRFTPGVKNPFPDVSFGENLYTYCVEGNTIGLDRRMSLDTNSTTVFDNGYFRSLVAGRGILTSDNILFTDPRTKPLVTQFAENQDAFFTAFKESMAKMGRIVVLTGTQGQIRKQCWVRNPIDANLRPEANMDFAPQSTKFCRQKPCNPTCSDPAS | 14 |
Q6P0S1 | 2.7.7.7 | ACT_SITE 304; /note="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity"; /evidence="ECO:0000256|PIRSR:PIRSR622312-50" | MEGHGHGILKAFPKVKRARPNDQKDAPPSKRTPAESITLTGTVFQGVTIYIVPAGIGKARCDIFHRQITQNGGQAVSTFAPSCTHVVVDDSVDFKRALRLLKVDTLPSAVHLIKCTWLSACISEKRLLDTEDYSLRPPESPTVAAAEKSNEATIQPVPEVAAQDPLQILDNLDPHENLTETIPPETQEEYHEEDGVSQNDLEALISGVHPSESNQDQKQSSADKPVLPGKWVCSQPSTTKGENHNKHLTDKLEPLAKAYTHTGDKWRALGYSKAINALKSYHKPITSYEEACKIPGIGKRMADKIMEIMESGHLRKLDHIGEEVPVLEMFTNIWGAGAKTAQMWYQQGFRTLEDIRTKAVLNHTLRIGLKHYDDLLERMPRSEANAIEKTVKDAAHSVDPQLLAMACGSYRRGRSTCGDVDVLITHPDGQSHKGVFSKVLHLLHQSGFLTDDLVSHEENGEQKKYMGICRLPGPSQLHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKNMSLSEHSLNCAVIRQRGVKLVAGTPLHTPTEKNVFQHLGIPYREPHERDW | 121 |
A0A9R0HST2 | 2.7.1.11 | ACT_SITE 214; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MEPKIVTGEGGYALDDVPHFSDYLTNLPTYPNPLQTNPSYSVTKQYFVDFDDTVVQKAVQHKDGPRGIHFRRQGPRQKVYFKPDEVTACIVTCGGLCPGLNTVIRELVCGLDYMYGVKNILGIECGYKGFYARNTLPLTPKTVDSIHKRGGTILGTSRGGYVTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYQEVRKRGLKVAVVGIPKTIDNDIPIIDKSFGFDTAVEEAQRAINAAHTEAESVENGIGLVKLMGRDSGFIAMFATLASRDVDCCLIPESPFYLEGEGGLYEFIGRRLRENGHMVIVIAEGAGEKVEERDPSGNKAFKDVGLWLSFMIKEHFAKTKLNITLKYIDPTYMIRAVPANASDNVYCTILAQSAIHGAMAGYTGCTVGPVNGRQCYIPFYRVIEKPNKVVITDRMWARLLSSTNQPSFMHPPKGAIIEGKQDEVVLSESAAEESNENEKCTPTSTSLSIHDNHVDDQYSMSNGSSELLLK | 84 |
O43063 | 3.4.25.1 | ACT_SITE 25; /note="Nucleophile"; /evidence="ECO:0000250" | MATTVKDTMNVDINAIKKGEIRMGTTITALRYKDGVILAADSRTTMGAYIANRVTDKLTQLTDNIWCCRSGSAADTQTVADLLKYYLSMYRIQFGHDPSVHTAATLASEMCYQNKNMLSAGLIVAGYDEKTGGDVYSIPLGGSLHKQPLAIGGSGSAFIYGFCDANFRENMTQEEAVEFLKNAVALAMERDGSSGGTIRMVILNKDGMERKFFAIDTANPIPVFTH | 180 |
E9Q612 | 3.1.3.48 | ACT_SITE 1146; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044" | MGHLPRGTLGGRRLLPLLGLFVLLKIVTTFHVAVQDDNNIVVSLEASDIVSPASVYVVRVAGESKNYFFEFEEFNSTLPPPVVFKATYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNVFSRVNISYWEGRDFRTMLYKDFFKGKTVFNHWLPGLCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPRNISVRFVNLNKNNWEEPSGSFPEDSFIKPPQDSIGRDRRFHFPEETPETPPSNVSSGSPPSNVSSAWPDPNSTDYESTSQPFWWDSASAAPENEEDFVSALPADYDTETTLDRTEKPTADPFSAFPVQMTLSWLPPKPPTAFDGFNILIEREENFTDYLTVDEEAHEFVAELKEPGKYKLSVTTFSSSGACETRKSQSAKSLSFYISPTGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPVIENLVPGAQYQVVMYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPILGVFRKYVVEMFYFNPTTMTSEWTTYYEIAATVSLTASVRIASLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDATTDLSHSRMLHWMVVAEGRKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSLPRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQLGSGHNGKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDTPSVPTFIAVSTMVTEVNPNVVVISVLAILSTLLIGLLLVTLVILRKKHLQMARECGAGTFVNFASLEREGKLPYSWRRSVFALLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDSYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSHIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMVSEEEEEDWASRHFRINYADEAQDVMHFNYTAWPDHGVPPANAAESILQFVFTVRQQAAKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWLRKKQQFCISDVIYENVSKS | 149 |
A0A251SZI7 | 3.1.1.11 | ACT_SITE 413; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MIKQLFSGVSDSGKKKKIFIAVFASILLIAAVIGIVAGVNSKTTNTQSDNIRASAAHTIVKSSCSITLHPELCYSTVASVPGMTEKVKSLRDVIELALEKTKERVQTNKLIIKTLAARRNLTKRGKIAVHDCLEMVDDTLEELDLVIDYVKNYATRKGIRKHVDDIITYLSTTITNQQTCIDGFSHNKPDRHLRQSIIGGEDNAGKLCSNSLALVKNMTDTDMANEVQTNTNTRKLMNEDDENWPEWLSAGDRRLLQSGNVRANVVVAADGSGNFRTISQAVAAAPSRSSSRYVIRIKAGVYRENVDVPSSKTNLMFLGDGQTKTIVTASRSVGGGSTTFNSATVAVVGAGFLARGITFQNTAGPANEQAVALRVGSDKSAFYECGFIAHQDTLYVHTNRQFYTNCYVAGTVDFIFGNAAVVLQNCDINARRPGPSQKNMVTAQGRTDPNQNTGIVIQKCRIGATSDLKPVQGTFPTYLGRPWKEYSRTVVMQTTIGNVIHPNGWFPWDGNFALNTLYYGEYQNNGAGSSTSNRVRWGGYRVITNAAEARGFTPGNFINGGSWLGNTGFPFSLGL | 125 |
P45142 | 5.4.99.25 | ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MSRPRKRWRDVDGVFLLDKPQGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQFLLDADKRYLVTAKLGERTDTSDAEGQVVETREVNLETQQILTALEQFRGDILQVPTMFSALKHNGKPLYEYARQGITVEREARPITIFELNFIEYNAPFLTLEVHCSKGTYIRTLVDDLGEVLGCGAHVTMLRRTAVADYPVAEMMPINELQLLAESFPLSELDRLLLPTDTAVSKLPALHLDAEQSKAIGFGQRVKFANEQQLSGQVRLFSAENLFLGVLNRREYYSPTTINYTIRITSLPFL | 218 |
P53965 | 3.6.1.52 | ACT_SITE 214; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:29540476" | MGLYQAKNDEGSDPKSSSKIDDLIENEAEIIRLIKEDGKLLIDNGDGRDIHNIIQEDKLLSVEFNEVLKRFHGEEKSDIPRKEFDEDEDDGYDSNEHHQKTIEVMNTLNHVINKEVIPPENFSHVVGEIYRSSFPRQENFSFLHERLKLKSILVLIPEEYPQENLNFLKLTGIKLYQVGMSGNKEPFVNIPSHLLTKALEIVLNPANQPILIHCNRGKHRTGCLIGCIRKLQNWSLTMIFDEYRRFAFPKARALDQQFIEMYDDDEIKRIASKNNWLPLQW | 190 |
A0A9R0K962 | 3.4.21.89 | ACT_SITE 154; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MTSLHLLPPISSLSNSTSKKSPKPIKNPNFTILNLHPCSIPLQFNKTPFNSHLKTPNSLSSNPLKPLNSLICRSLKESQDDTKTTLSTKSGGGDGGGGGGDGEGDDGNKGDSSSLLPEWLNFTSDDAITVFAAVAVSLAFRSFIAEPRFIPSLSMFPTFDVGDRLVAEKVTYYFRKPCPNDIVIFKSPPVLQDVGYTDNDVFIKRVVAKAGDTVEVKDGKLIVNGVVKDEAYIFESPKYNMTLTRVPENSVFVMGDNRNNSYDSHVWGPLPAKNIIGRSLFKYWPPNRIGSTVLPEGCAIEKQESPSTSS | 178 |
H9GCN5 | 2.7.10.1 | ACT_SITE 744; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MVLRLPSVKACLSFELLLLLWVSLLCEVAGKEVNLLDTSTAQNELGWLPDPSESGWSETQHMINGTPVYMYQDCSVLSEGDTDHWLRTNWIIRDVASSNIFVELKFTIRDCKSFKGEVVSCKETFNLYYMESDNDVGIQFRRPLFTKINTVAGDRSFTARDIASGDMQLNMEVSSIEKLHQRGFYLAFQNSGACVALVSVRVYYKTCSESVHGLAHFPETLASSEGLETVFGTCLKDAAEKPGFPPKMHCSSNGEWLLPMGQCICVIGFEEVEGACVGCQPGFYRHSLETEKCLKCPPNSFSSSPAATACPCHKGFFRTPTEDQTIACTRPPSAPHNVTSSLVGSQVSLTWQPPIDQGGRSDLSYNVSCKRCHFLVCEPCESDVVFSPRALGLTRTNVVVDGLESYTNYSFTVRAYNGVSGLSSASHKSTSSSVWVTVGYADPIIVTNINLDSQNESSLSVTWLPTRHRSHVPISYEVMYFEKGEEKHYTVQHLKEPKVTLANLQPDTSYLLRVRSVTPSGEGPFSQEQEFRTLPQETGIPSGGMIVCIIFGILLFIGLVGGLIILRRRQAHRRARPCQKHSSYNRDDIWLKPYVDLQPYEDPSRGVLEFTKELDPSLVNIENVIGEGEFGEVYRGSLRFPGKDHIVVAIKTLKSSYSDSTWWNFLREATIMGQFNHPNIVRLEGVVTKRNPMMIITEYMDNGALDNFLRENMDKFSAVQLVIMLQGIASGMTYLSDRNYVHRDLAARNILVSHSHQCKVSDFGLSRILENDVEGTYETKGGKIPIRWTAPEAIAHRIFTSASDVWSFGIVMWEVFSYGDKPYGDMSNQEVMKSIEDGYRLPPPVDCPSVLYELMKACWSYDRARRPRFREIQAQLDHFISSPHLLRSVADFDPRVTLRLPSCSGSDGIPYRSIPEWLESIRMKRYILNFRTAGLNTMESVLELTAEDLKQMGVTLPGHQKRILCSIQGFKE | 97 |
B8CBQ0 | 2.3.2.26 | ACT_SITE 314; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSLSRKDLRKVWRFEFIGEAGIDAGGLAREWFELVTEEVFDPDMGLWQTSATNQMCMQINPASEISCPDDHLIYFRFIGRVMGKAMFDRQLVKGHMVKHLYKHILGWPIMFNDLKDIDEEYYNSLKGLKDMGADVEYVGVDFTVMEETLGVKSTVDLVPDGANIDVTEDNLPEYIEACLKYRMLGRYEAQLNELLLGFFDVIPEPLLTIFDFQELELLMCGLPEIDMQDWQDNTEYSGEYDRDGPNHEVCRWFWEIVSEYDHEMRARLMQFVTGTSGVPARGFGSLQGNDGNVRKFTIHGVSLETCVYPRSHTCFNRIDLPLYEDRDDLEEKLKIAITMASTGFDIE | 65 |
A0A059AJM6 | 1.11.1.7 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MARMTNRAAVDVMWGVMLLMQMMGLIRSFNFGIGGVDGLRMDYYFMSCPFAEQIVWNSVTSALQSDPTLAAGLLRMHFHDCFIQGCDGSVLLDSTKDNTAEKDSPANLSLRGYEVIDDAKEQIEEQCPGVVSCADILAMAARDAVFWAGGPRYEIPKGRKDGARSRIEDTINLPSPTFNASELIRMFGQHGFSAQEMVALSGGHTLGVARCSSFKQRLSNSDPTLDSSFAKTLSKTCSAGDNAEQPFDATRNTFDGAYYYGLVNKVGVLTSDQTLFASARTKGIVNGYAMNQAMFFFDFQQAMLKMSLLDVKEGSAGQVRLNCRKIN | 14 |
P0C1B3 | 3.2.1.1 | ACT_SITE 227; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:9283074"; ACT_SITE 251; /note="Proton donor"; /evidence="ECO:0000305|PubMed:9283074" | MMVAWWSLFLYGLQVAAPALAATPADWRSQSIYFLLTDRFARTDGSTTATCNTADQKYCGGTWQGIIDKLDYIQGMGFTAIWITPVTAQLPQTTAYGDAYHGYWQQDIYSLNENYGTADDLKALSSALHERGMYLMVDVVANHMGYDGAGSSVDYSVFKPFSSQDYFHPFCFIQNYEDQTQVEDCWLGDNTVSLPDLDTTKDVVKNEWYDWVGSLVSNYSIDGLRIDTVKHVQKDFWPGYNKAAGVYCIGEVLDGDPAYTCPYQNVMDGVLNYPIYYPLLNAFKSTSGSMDDLYNMINTVKSDCPDSTLLGTFVENHDNPRFASYTNDIALAKNVAAFIILNDGIPIIYAGQEQHYAGGNDPANREATWLSGYPTDSELYKLIASANAIRNYAISKDTGFVTYKNWPIYKDDTTIAMRKGTDGSQIVTILSNKGASGDSYTLSLSGAGYTAGQQLTEVIGCTTVTVGSDGNVPVPMAGGLPRVLYPTEKLAGSKICSSS | 157 |
Q67IX6 | 5.3.4.1 | ACT_SITE 102; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 105; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 444; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 447; /note="Nucleophile"; /evidence="ECO:0000250" | MRSRSLLLVALATLLLHASASASDDDLDYLIDNADDIPANDPDGWLQEGSPDDDDDDDLFHHGQAQDHPIDETHVFLLSAANFSDFLASHRHVMVEFYAPWCAHCQALAPDYAAAAADLSPLAHQVALAKVDATEDTDLAQKYDVQGFPTILFFIDGVPKDYNGARTKEAIVSWVNKKLAPGVQNITTVDEAEKILTGEDKAILAVLDSLSGAHSDEIAAASRLEDAINFYQTSNPDVAKLFHLDPAAKRPSLVLLKKQEEEKLTFYDGPFKASAIADFVSANKLPLVNTLTQETAPSIFDNPIKKQILLFVVANESSKFLPIFKEASKSFKGKLLFVFVERDNEEVGEPVANYFGITGQETTVLAYTGNEDARNFFLDGEISVENIKRFAEDFLEEKLTPFYKSEPVPESNEGDVKIVVGKNLDQIVLDESKDALLEIYAPWCGHCQELEPTYNKLGKHLRGIDSLVIAKMDGTANEHPRAKPDGFPTILFYPAGKKSFEPITFEGDRTVVEMYKFIKKHASIPFKLKRPDSSATKTEKDQSTASTNLRGERSSGTNFKDEL | 215 |
P29340 | 2.3.2.23 | ACT_SITE 115; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MPNFWILENRRSYTSDTCMSRIVKEYKVILKTLASDDPIANPYRGIIESLNPIDETDLSKWEAIISGPSDTPYENHQFRILIEVPSSYPMNPPKISFMQNNILHCNVKSATGEICLNILKPEEWTPVWDLLHCVHAVWRLLREPVCDSPLDVDIGNIIRCGDMSAYQGIVKYFLAERERINNH | 64 |
B6K5F9 | 2.2.1.1 | ACT_SITE 421; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MVSTYTDLDTKAVNTIRTLAVDTTCKSKSGHPGAPMGMAPAAHVLFSRIMNFNPQKPRWINRDRFVLSNGHACVLQYALCHLLGYNLTIDDLKNFRQLGSKTPGHPENHNPDLCIEVCTGPLGQGITNAVGLAIAQAHTAATYNKPGYDLINNRTFCFLGDGCLQEGVSSEASSLAGHLKLGNLVAVWDNNKITIDGSTDVSFDEDVEKRYEAYGWQVLRVADGDSDYASIEQALLDAVACKDKPTLINMKTTIGYGSMKQGTHSVHGSPLSAEDAAHVKREFGFNPEQSFYVAPEVYDLYKKHVARGVEAQQKFDELFAKYKTEYPELAAQFERVVEKKLPEGWEKKLPTYKPTDPAIASRKLSEIVLDSIAPVLPELVGGSADLTGSNLTRWKGAVDFQPKESNLGDYSGRYIRYGVREHAMGGIMNGMAAYGTVIPFGGTFLNFVSYAAGAVRLAALGQFRTIYVATHDSIGLGEDGPTHQPIETYAHFRAMPNINCWRPADGNETSAAYHSAISLAQTPSILALTRQNLPQLNGSSIEKALKGGYVLVENKDANVTLIGTGSEVSLCVEAAKVLEAEHGLKARIVSMPCCEIFDEQAQEYRLSVLPDGIPIMSVEVYSTVGWKRYAHEAFGIDSFGDSAPYQQLYAKYEMTPEGVAVRAKMTVDAWKPVQNIRSPIHHAF | 51 |
Q8IL26 | 2.7.11.1 | ACT_SITE 660; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MTSEDKTALCAENILNDIYILTINRNIDIDIIQEGLLRKVMDEEESNSILFLEDSSFSKNDISILNVHLKIEDGKNKYNNYYEFKYADINVTIDFYQKECKYSIEKSNMHKCHYFKMMNKINYITEQKMDFKDSILYLYNTINDKNFFKCPCWLNDNKNIKLNNIINDHQQKKKKKNLYDKSVQVTNDVTNIMVNEIQEQKMKKPIFFDNKNDLNNSDDEFNSAHSSLIKINKLLNVEENDIFHNLKGHVYEEYFDKHEDNKNQKDNIESNIIVKDKKDRANNIISEQMKEDYIKNVEEVLSKHINNNKNNNVEDSVSLYSLDEEISEQIDKQHFFSIDKRQDEISNFIQMEENINDHMNDNINKMGKKKHGKENRVVEDEKYIQDDKKKKRFYRNVNDNIPLTVQLANKGNEICKEIIEMNSRYYRDFFEEKILGCGGFGYVMKVKNKKFNITYALKIIRLSNSKYNTQTNNKHINEKDNNSYIMEEAIMIAKLQHENIVRYYDAWVEENVDFFLYKELQNEFKNIKIKIKNEKMKNEKMKNEKIISGKIKNENIKSENIKSENIKSENIKSENIKSEKVKNLYIEEIKYFWNHYKKNKDPNVNDKYLYILMEYCPGKTLREAIDCGFICRNEKLIWELIKQILKGISYIHDMKIMHRDIKPSNIFLQITDNILIAKIGDFGLTTRIGDTQINPSAGTIHYISPEQLNGEPFNEKADIFSLGVVFFEMFHEPFSTSMERSITLSNLLKGIYPEYMKADNKKFQFLSSLLAINPQERCCAYNLLHESVLFTFEKDFTDIYNLIDNKRNCEEVHTIISTLFDKFEYLNSDKILKKEDFSTFQNAKIFTDDLEMRKKQKIIKKKILISLKKRGAIFILTPIILLNKYYINLENTYMEEYNIYYNINKKKENKINNIYINTNKNKNIDNLIYMLDIYGNSITLRNSFFLSFAEYIYESIDSYNKYNEDNLFYKFYTYGYTYKNQIIKSNKHIKKDTINNNINTTINITTTTCNTTTGTSTNNNNNNNNNNMGNNNIGNNMGNNVSNIISNNNINNHMISNNPFYFYNIYPDENEKMFYCILSSSKNVFGNEELNYLSIFSNADIMVSIYTLYNHINYFNKLLFVWSYIDLLEIILKECLDIPNDISYHLSIDLKKNSTLLVNKSFVMSLLQKYKIKDMSKISDHILSLFYIKCESNKVDDYLNNIYNFVDDLLNKKSSLQLKRNTSITPKEVPYVRSRSNNISTSASKIIKYDIQKNVGTKEKGNQNDNEKKKMQIYSILDRIKKINNFICTNTVINNTCFDLFLNYEESIFCNEVIFYVICESKNKEIIAYGGRFDEIIRNMANEVKYKNHANYKYVYNNIKDIYNNNNNNNNNDNNIMNIKAYGVEIYLDKIYSKVIESNEKISIHLQYNPSTDKSQLFKNFVTSCQQNDFACTSHIIQQPLLNDDYLNYSSTKILIQVYEISNLLIAYDLSKKLLTKNISSYTHLSINNVNIKKKIKNFKPHKIQFFITIKSNNTDNSFDALKPINFDNVVYKIVNYDDQDCNFMDQAELINYLIKYF | 99 |
A0A2K2B4M4 | 2.1.1.37 | ACT_SITE 833; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MKSSSSPTDSRKLTPLQVYESTSTSRRSPRLAPPNNNVPSKTPKSNKPKTTHISLRRSPRLEPTPASPQSVSRKKHSRNVSKTKCSARNVSVDRKIPSRSSRVGNSRMQNVAANRTVLLDSSALRRSPRLSSADMEIVVSERNASVVVADTARLRRSPRLANGYAEVAVSKVRTFLKRKRVSDEMSRSPRNQNGRLDVQFALVQSEKCSRFIVNEENERNCLKVECSSKDLSKGSPVACSSANAKLGCCEKRGCQSVLLTISDSEVGDSGEFEAKPLLLPWHGDNESQTGMVKCDDGSSVFEEEPLRMSPSFDFANENAVINESPIKSCKWSSALDGDGNFEVISCSSGIFDSNDACPSKRVKICEENSVSGMSDEKLLRRSPRTNSIVVTENGENKSGKKQSPKTNSGKELSLEKASSGKKQKEHRGNCSLIGDPVAHDEAQERWHWRYEMKSKRTKHPRLALDDDDEDKVVWNVECHYTQANIEGRIINLGDCVYVKGEGAKNHIGSILEFFKTTDREDYFRVQWFYRAEDTVMKEAADFHDNKRLFYSTVMNDNPIDCIISKVTVVQISPRVHLKFHSTPASDFYFDMEYCVDYSTFRTLLTDCSLRGHELSPLPFCDSRSATPSDISMENMSTCGSYKAKLTLLDLFSGCGGMSTGLCLGAKVSCVDLVTRWALDSDESACQSLKLNHPETHVRNEAAEDFLELLKEWQKLCKRYAVNDVGRTHKSRSMASSMSKQNKNSSNDDDIASGEYEVARLVDICYGKTDKRGKRGLKFKVHWKGYSTSEDSWEPIEGLSNCEHSIRDFVREGFKSKILPLPGDADVICGGPPCQGISGYNRYRNVDSPLADERNIQIVVFMDIVQFLKPKYVLMENVVDILRFDKASFARYALSRLVHMKYQARLGTVAAGCYGLPQFRLRVFLWGAHPKEKLPQFPLPSHDVIVRYWPPPEFERNTVAYDEDQPRDDLEKATVLRDAISDLPDVTSHETREEMAYDKPPETDFQQFIRSTRNEMTGSELSGTRMINLLYDHRPYSLTEEDFARVCQIPKKKGANFRDLPGVVVGADNVARRDPTEEQMLLPSGKPLVPDFALNFEGGKSRRPYARLWWDETVSTVVTFPDLHSQAVMHPEQDRVLTIRECARLQGFPDYYRFCGTVKQRYRQIGNAVAVPVGRALGFTLGMAFQKLSGDDPLMTLPPKFSHSTNLQLAKSLFQKAE | 47 |
P0AF24 | 3.1.3.5 | ACT_SITE 9; /note="Nucleophile"; /evidence="ECO:0000305|PubMed:16430214"; ACT_SITE 11; /note="Proton donor/acceptor"; /evidence="ECO:0000305|PubMed:16430214" | MTIKNVICDIDGVLMHDNVAVPGAAEFLHGIMDKGLPLVLLTNYPSQTGQDLANRFATAGVDVPDSVFYTSAMATADFLRRQEGKKAYVVGEGALIHELYKAGFTITDVNPDFVIVGETRSYNWDMMHKAAYFVANGARFIATNPDTHGRGFYPACGALCAGIEKISGRKPFYVGKPSPWIIRAALNKMQAHSEETVIVGDNLRTDILAGFQAGLETILVLSGVSSLDDIDSMPFRPSWIYPSVAEIDVI | 150 |
A0A7I4EL45 | 2.2.1.1 | ACT_SITE 567; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MEATAAAMAMQKSPGAPRALNEGTQVRVPASRSVVSGAALPRCSQPAACLSKATQTSKWTGNWKPEKLAKLREANPFASFRRGLKMPHGARADSQSLQDEQVKTGQPGTQKQSVPSKIVDRKESSTPKEHMKAWKEEITSMLGGKEGNWEDSKWFQSQIDKRCVDNMRMLTVDAVNTAKAGHPGLPLGMAEVGYVLWRYVMKFNPKNPNWFNRDRFVLSAGHGCLLQYITLHLSGYDSVQIEDLKRLCQIGSRTPGHPENVTTDGIEVTTGPLGQGVANAVGLALAEKHLAARFNKHDGKIVDHRTFCIMGDGCAMEGITNEAASLAAHWKLNKLTVIYDDNHNTIDGDTSLAFSEDVGARFEALGWNRVVIDNIYHDIDSFKEAVLNFAGKSDKPTFIQVKSRIGRESVKENTAKAHHGTFDEDDVKHMHKNLKWENREPFYVIPQVYEEFTDHAKHGISEEEEWNEALEDYSKKYPEEARNFKELISGELPKDWEKAIPHFPEDEKIDATRGYSETCLNAVAKVLPGLIGGSADLASSNKVYMKDFPDFSAETPEGRNIRYGIREHAMAGISNGLALHNSGLIPIAATFLIFSDYMKNSMRLSALSEAGVIYILTHDSIGLGEDGPTHQPVEQLAGLRAIPGMYVLRPADAKEVAGAYKVAISRRHAPTVLSLSRQKVAANVGGTSAEGVLKGGYVVSDNTDENSLPELILIGTGTELALCEKSAETLRQEGKKVRVVSLVCWQLFDQQPEEYREKILPSAMEKRISVEAGSPFGWREYVGSKGKILAVYTFGCSGAYTKVFEKYGFTAENITDVAQKLLTETETRNQN | 51 |
B9RK96 | 3.5.4.5 | ACT_SITE 79; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MEPPRFVIEASEAESMAQKAGLTLVELLPTLVKSAQSLARPPISDYYVGAVGLGSSGRIFFGANLEFPGLPLHQSVHAEQFLITNLFLNAESNLKYVAVSAAPCGHCRQFFQEIRDAPDIQILITGDSNNTNNNDQSNGDIKRFDTLSNLLPQRFGPYDLLDKSVPLVLEKHNNHMSLQNDDISNNSKKVPNGISISVFDDLKLEALEAANSSHAPYSKCPSGVALMDCEGKVYKGSYMESAAYNPSLGPVQAAIVAYLVGGGGGYEKIVAAVLVEKEEAVVRQEFTARLLLQVISPRCEFKVFHCSSSKS | 187 |
A0A8V0ZFG5 | 3.1.1.4 | ACT_SITE 67; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 111; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MNALLALAILFAWGSSLAGGSLWQLQEVVTKMTGKNAVLNYSSYGCYCGVGGHGQPKDATDRCCQLHDTCYDSLQRYHCNAKKQRYKYSWHSGRLTCNRDSWCAQLSCECDRSLGLCLQRNRRSYNWRYVLYPRCKCR | 130 |
A0A078F6G3 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAIKNLLVLAVLLSVLGVSVANSKGLDLNYYKHRCPDVETIVRRTTVQYVSRQPSLAAALLRMYFHDCFVRGCDGSILLKSPNKDAERDAIPNLSVRGYEVVDAAKAALEKKCPGLVSCADSPETLFNAFFSQINGPWWPVPLGRRDGRISRKSEVNLPSPFAGIAALKKNFFDKGLNTKDLVVLSGAHTIGISNCGLINSRIYNFTGKGDFDPSMNPSYVRALKKRCKPTDFRTSVEMDPGSVKKFDSHYFNIVAQKKGLFTSDSTLLDDPDTKKYIDTQVATAGSSFNKDFSESMFKLGFVEIFTGNKGEIRRKCAFVN | 14 |
A0A6I8NME7 | 2.3.2.26 | ACT_SITE 1298; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MARRLRLHFAARRRNTDPLSESSGDDLDDNPPMCFRRPSPAPASNTVQMKLTPRQTVLPPGAREIVRSQEGSAAPSSQSRHKKSTFLQISLRPTRSDGYLRAGTVVAAGEEASFSGVIEEANCDGTVVDNGLNVINDNGLLGSPASCHGSLSSFGASDSGSYSSNGSDYGSGTSTASDGVSCSISISSDSGGRTLPRGDGSLANGIVCGSPSYADAYKRVPNRCATPCETLRSDSSISFEEGLEQAIENAKSPARTKSKIPLRRCSSLVIFPRSPSTTPPTSPTSLSPLPSRGPYQTSHQFLVSPGELAQSQDPTPPRGFLSTAVNGLRLSRTVCLPGEVRDIRPLYVRSSPREKNLSSVKTPKKTVREKSPEGRSSISVRFTQRRTYASRSEATNGHCRLEKPLEELKLNSGGKHPHLKLIRSTSACLPASQDADCRPDANGELGKPNSQASQNHHLLQRSISLEGSYQNVPCCLSSLKYNCSKVGTSQLHIQFARGNEGKVSNLQKESKRYCKRELCNNSRRSQRTRDDFLGQVDVPLYQLPTENPNLERPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTNGSEEENTEQAEELEPGWIILDQPDAACHLQQQQESSPLPPGWEERQDVLGRTYYVNHESRRTQWKRPTPQDSITEAESGNIQLQAQHAFTTRRQISDETEILENRESPESWDIITEDEATMYSHQNIQSPPTPSNFDIQSHLAEELNARLTTVGNTATSRQASSSHHSSRRDNVQTYTVEEQPALPVLLPTSSGLPPGWEEKQDDKGRSYYIDHNSRTTTWMKPAIQATLEAGQPSSSQSSSLSHQPQTAATDPSQHSLHQQPELQQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRRKTSLDPIDLGPLPPGWEERTHTDGRLFYINHNIKRTQWEDPRLQNVAITGPAVPYSRDYKRKYEFFRKKMKKQSDIPNRFEMKLRRTAILEDSYRRIIAVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHKPITLHDMESVDSEYYNSLQWIIENDPTELDLRFTVDEELFGQTHQHELKADGSEIVVTNKNKKEYIHLVIQWRFVNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYNVNHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQFFTVEQWGSPDKLPRAHTCFNRLDLPPYESFEDLWDKLHVAIENTQGFDGVD | 65 |
A5D7P0 | 3.1.3.48 | ACT_SITE 381; /evidence="ECO:0000250|UniProtKB:P30304" | MSAEFFSSKREEGSLASGPSFRSNQRKILNLLLERDASFSISSDLPTTPVEKKLFGDSANLSILSGGTPKRCLDLSNLSSGEMSATQLTASADLDETGHLESTGPEQVRLAGMNYRQHLIKCSPAQLFCSTPNALEHGRRKKDAICGSSANKENDNGNLVENEMKHLGSPITTVSKLHKNPELAEDQAEEISDELMEFSLEDQEKAKPPLNWSSLYRSSSLPDSLNSPSLKQVVKFKDSTIPDKLKKKYCSNQKELGKGLGLKKMVSLCDINMTQMLEEDSNQGPLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGEFQGLIEKFYIIDCRYPYEYLGGHIQGALNLHSQEELYNFFLKKPIVPWDNQKRIVIVFHCEFSSERGPRMCRSLREEDRTLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKAELLRCRNQSKAWEGERQLQEQIALLVKDVSP | 149 |
A0A7M7N573 | 2.7.11.1 | ACT_SITE 211; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MTSEYGKENSTQAHMSSKAHMTPVSVPRANAGPKRILKPNTTSSNVASSLNRGTTAQARTQPVKSAENGHGHDDKQMEPKKSWTLKDFDIGRPLGKGKFGSVYLAREKQTKYIVALKVLFKSQLQKAQVEHQLRREIEIQSHLRHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRAGRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDLKIADFGWSVHAPSSRRNTLCGTMDYLPPEMIEGRMHDDKVDLWSLGVLCYEFLVGKPPFEAEGSTETYRRITKVHYQFPSYVSAGARDVIKRLLQHNPANRLPLEQVLAHPWIVENSKKKPSSSSTSSSESQS | 99 |
A0A6I8N5K6 | 3.5.1.98 | ACT_SITE 739; /evidence="ECO:0000256|PIRSR:PIRSR037911-1" | MHRPSLDGSEVSLGTRRHGPPGPAYETLRGTPPGPQAAPMDLRVGQRPPPPAEPPAVEPSTPEPALLALQHTQRLHHQLFLASLQPRRPEHIRLSLETPGPEVPAGQQEQELCHLLHKDKSKRSAVASVAVKQKLAEVILKKKQAALERTGHANGPGVPGPGIPYRTLEALESEGGSPSMLSGILPPVPSLPSDPPEHFPLRKTVSEPILKLRYKPKKALERRKNPLQRKESAPPSLRRRPTEPLGGESARQAQWGAGTPRGKSEASGRTDPCPVQSRFPPLPPTDSSPSSSSTPVSGCSSPNDSEHGPCPAPGHEVDGDRRTLPAVGPRVPVLGASHASLFLSQGLEPEASGALPSRLQPVLILEPSASHAPLLAVPGLGPVPFHFAHSLLSAERLPWPGPHRPLGRTRSEPLPPSSAARQQQQQQQQLLLGSQQPRNLERLKQHSPLGKWPAKPSEKPRLQQIPSAEDLEADGGDGRFGARDPERRELVLGRLEPEGPSEPLRHLGLNPQQQQQVFLREPQRVSGHPPRVAPGNTLLLSFAQGGHRPLTRAQSSPAAPASLPSTEASSKSGGLPGPETPARTTAFTTGLVYDSVMLKHQCSCGDNSNHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHAERHVLLYGTNPLTRLKLDNGKLAGILSQRMFVMLPCGGVGVDTDTIWNEMHSSNAARWAAGSVTDLAFKVAARELKNGFAVVRPPGHHADLSTAMGFCFFNSVAIAARQLQQKGKVGKILIVDWDVHHGNGTQQAFYQDPRVLYISLHRHDNGNFFPGSGAVDEVGAGSGEGFTVNVAWAGGLDPPMGDPEYLAAFRTVVMPIAREFSPDLVLVSAGFDAADGHPPPLGGYCVSAKCFGYMTQQLMSLAGGAVVLALEGGHDLTAICDASEACVAALLGSTVDPVSEETWRQTPNANATHALQAVIRVHSKEGEEGWAGGRGPRSEGGRVGGNPRFTPLLFPGKYWGSMKQLSSWPDPWDPEPPGTDSEEVEAVTALASLSVAVLAEKRPSEQLVEEEEEEPMNL | 184 |
A0A3B3I7P3 | 3.1.4.11 | ACT_SITE 330; /evidence="ECO:0000256|PIRSR:PIRSR628391-1"; ACT_SITE 375; /evidence="ECO:0000256|PIRSR:PIRSR628391-1" | MACVRRQSELSRSQELFQHARSQKVIQTNVKLLGLEGDPDLQFLLQGGDLLKVRSRSWKKTRFLQLQEDCKTMYRKSDKLFKSHQTFPIDDISSVRIGRQSEGLKKNTEEQLESRCFSIVFKSRRKNLDLVASSHEEAKQWVRGLEKLLSNVNNLSRQETREHWIFNCLKKADKDKDEKLNLSEVKRFLRLINIEMDDSYAEVLFQNCDKSKSGYLSGQEIKELYDLLSQRVEIDVIYQEYAKTTGFMSAHNLVEFLMKEQRERASLADAHSIIDKYEPDEQVKQKKLLSKDGFLMYMQCPEIMILNQEHKELYQDMQQPLSHYFISSSHNTYLLEDQLKGPSSTEAYIRALMKSCRCVELDCWDGSDDEPVIYHGYTLTSKILFKDAIQAIKEYAFKTSNYPVILSLENHCSVEQQAVMARHLSSMLGSALVTAPLGDGMPTNFPSPEELKGKFLIKGKRLNKLEANFTSEAAGDDTDVTEEEESSDETDEEQKKKSKLKLAKELSDMVIYCKSVHFNGFEDAQKNLSFYEMSSFKEGKAMKLAKESANAYIHHNVEKLSRVYPAGSRTDSSNYNPVPLWNAGCQIVALNFQTSCSEMDINQGRFLVNGKSGYILKPAFMRDPSSEFDPNTPTPGDWRQPKTLHVMVISAQQLPKVNQKKSSIVDPLVKVEIYGVPDDMAVKETTAIENNGFNPSWNESFQFGVSVPELALVRFVIEDYDSASSNEFVAQYTLPFTSLKMGYRNMPLLNRNGDLLPSAGLFVHIMVLNA | 153 |
K7DCW7 | 1.8.1.4 | ACT_SITE 516; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MRREGRPWRSGGGAQRRWKYWRKGKYSGKMQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF | 36 |
P77872 | 1.11.1.6 | ACT_SITE 56; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"; ACT_SITE 129; /evidence="ECO:0000255|PROSITE-ProRule:PRU10013" | MVNKDVKQTTAFGAPVWDDNNVITAGPRGPVLLQSTWFLEKLAAFDRERIPERVVHAKGSGAYGTFTVTKDITKYTKAKIFSKVGKKTECFFRFSTVAGERGSADAVRDPRGFAMKYYTEEGNWDLVGNNTPVFFIRDAIKFPDFIHTQKRDPQTNLPNHDMVWDFWSNVPESLYQVTWVMSDRGIPKSFRHMDGFGSHTFSLINAKGERFWVKFHFHTMQGVKHLTNEEAAEVRKYDPDSNQRDLFNAIARGDFPKWKLSIQVMPEEDAKKYRFHPFDVTKIWYLQDYPLMEVGIVELNKNPENYFAEVEQAAFSPANVVPGIGYSPDRMLQGRLFSYGDTHRYRLGVNYPQIPVNKPRCPFHSSSRDGYMQNGYYGSLQNYTPSSLPGYKEDKSARDPKFNLAHIEKEFEVWNWDYRADDSDYYTQPGDYYRSLPADEKERLHDTIGESLAHVTHKEIVDKQLEHFKKADPKYAEGVKKALEKHQKMMKDMHGKDMHHTKKKK | 13 |
Q9XF43 | 2.3.1.199 | ACT_SITE 225; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 304; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 388; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 392; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 421; /evidence="ECO:0000250|UniProtKB:Q38860"; ACT_SITE 425; /evidence="ECO:0000250|UniProtKB:Q38860" | MPQAPMPEFSSSVKLKYVKLGYQYLVNHFLSFLLIPIMAIVAVELLRMGPEEILNVWNSLQFDLVQVLCSSFFVIFISTVYFMSKPRTIYLVDYSCYKPPVTCRVPFATFMEHSRLILKDKPKSVEFQMRILERSGLGEETCLPPAIHYIPPTPTMDAARSEAQMVIFEAMDDLFKKTGLKPKDVDILIVNCSLFSPTPSLSAMVINKYKLRSNIKSFNLSGMGCSAGLISVDLARDLLQVHPNSNAIIVSTEIITPNYYQGNERAMLLPNCLFRMGAAAIHMSNRRSDRWRAKYKLSHLVRTHRGADDKSFYCVYEQEDKEGHVGINLSKDLMAIAGEALKANITTIGPLVLPASEQLLFLTSLIGRKIFNPKWKPYIPDFKLAFEHFCIHAGGRAVIDELQKNLQLSGEHVEASRMTLHRFGNTSSSSLWYELSYIESKGRMRRGDRVWQIAFGSGFKCNSAVWKCNRTIKTPKDGPWSDCIDRYPVFIPEVVKL | 56 |
A0A251TGE0 | 3.1.1.11 | ACT_SITE 421; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVTTFVSSPPNQAPPMHTLTSTLACVYKPLTLLIYFTIILTLNLQSMASTTTIFSILILLTYAATTATSQPPSSSSTVCQSTPYPSFCQTTLPINNSSATIYDYGRLSIRKSITAASKFANSIDKYLSNSPGLTTGTVRALQDCQYLAKLNLEYLSNAFATVNTTQTTLSDTKSEDIQTILSAILTNTETCIDGLQSNAASWTSKDGVVSPIKNDNKLYSVSLALVNKGWGSKKSKKNRVSHKHKGLEAISETVGRRKLLQVDGTGSQVVVSQDGSGNFTTITDAINFAPNNTSPSTAGYFVVYVTAGVYEEYVNIPKNKKNLMMIGDGINQTVITGNRSVVDGWTTFNSATFIVVAPNFVAMNLTIRNTAGAIKHQAVALRSGADLSTFYKCSFEGYQDTLYAHSLRQFYRECDVYGTVDFIFGNAATVLQNCNLYPRLPMSGQFNAITAQGRTDPGQNTGTSIQKCNIRAADDLAASNGTTVTYLGRPWKEYSRTVYMQSFMDSLIAPAGWSVWSGDFALNTSYYAEFNNSGPGSDTSQRVTWPGFHVINETDAVSFTVSGFIVGDAWLNQTGVPYDAGL | 125 |
P0ABF6 | 3.5.4.5 | ACT_SITE 104; /note="Proton donor"; /evidence="ECO:0000305|PubMed:8289286, ECO:0000305|PubMed:8634261, ECO:0000305|PubMed:9125497" | MHPRFQTAFAQLADNLQSALEPILADKYFPALLTGEQVSSLKSATGLDEDALAFALLPLAAACARTPLSNFNVGAIARGVSGTWYFGANMEFIGATMQQTVHAEQSAISHAWLSGEKALAAITVNYTPCGHCRQFMNELNSGLDLRIHLPGREAHALRDYLPDAFGPKDLEIKTLLMDEQDHGYALTGDALSQAAIAAANRSHMPYSKSPSGVALECKDGRIFSGSYAENAAFNPTLPPLQGALILLNLKGYDYPDIQRAVLAEKADAPLIQWDATSATLKALGCHSIDRVLLA | 187 |
A0A8J1M3D0 | 3.1.1.4 | ACT_SITE 92; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 141; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MLFVRVSSTLLVSSNTPKTYRPVNWFLIKWILVLSPALANTNTRNLWQFRNMIKCTIPTCDPYFDYNDYGCYCGIGGSGNPVDALDRCCQSHDNCYSNSKGPCNGILDSPYIEMYDYTCSGTSVTCSSKNNACEKFICECDRNAAICFSGAGYNLKYKNLDRSTNC | 130 |
Q54DU9 | 3.1.3.48 | ACT_SITE 75; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 107; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MTGIRSALPNPASLVESSTHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALIEGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSKKKSSCRIM | 149 |
Q9RJS6 | 2.7.1.23 | ACT_SITE 68; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00361" | MTIERVGLVVHGGREGAAEAAREVREWCDENAVACTDIDVWSDTGRHSAREEVDAAGDPDLVVTLGGDGTFLRGARLAAENDALILGVDLGRVGFLTEVPAPAVRSALDAVRDGGLEPESRMLLTLRASRLLEIPAEMEALLRYGRGPLLPPPRVRTDCESGDEWGIALNVTALNDVVLEKLSRDRQISVGVYIAGRLLASYSADALLVATPTGSTAYSFAAGGPVVSPRAEALVFTAVAPHMTFDRSVVTAPDEPVGLRILERSGRAAVSIDGQLRGVLDPGDWLGVYAAPRRLRAVRLGPMDFYGRLRERMRLTDAPAAVADGTPAPLWPVSTPPPGDLAHLALPVPGAEGASGDLLREQS | 89 |
Q55848 | 2.7.6.1 | ACT_SITE 214; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MSAVSRIATLTRQSMLSALSDNNRLRLFSGSSNPSLSQEVARYLGMDIGPMLRKRFADGELYIQIQESIRGGDVYLIQPCCHPVNDNLMELLIMIDACRRASARQITAVLPYYGYARADRKTAGRESISAKLVANLITGAGAQRVLAMDLHSAQIQGYFDIPCDHMYGSPVIIDYLKSKQLTDLVVVSPDVGGVARARAFAKKLNDAPLAIIDKRRQSHNVAEVLNLIGDVDGKTAVLVDDMIDTAGTLSEGSRLLRAQGARQVYACATHAVFSEPAINRLSGGLFEEVIVTNTIPVPDDHHFPQLTILSVANLIGEAIWRIHEESSVSSMFR | 114 |
W5N9Z9 | 2.7.10.1 | ACT_SITE 784; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MLTMGYTWVSLFTLMLLWFEKGWTEPVITPNLSYMVLLKGGSFTLQCRDNSSVKWSLERDVGYKKDLKSENKDGSYYLTISYAKPDVMGRYVCINEQTLAQSSVYIFVKDPPNLFQKTIMVDVISRVGDDPIIPCLVTDPDTKGLKLEKCSGEPVPKEMNTTASIEKGITINSVQKIFEGCYVCTAKYNGKDVKSDEYNLIVRLASSHAPDIKLDKNKKVILIKGETFEVKCSTVNVDHAFTLGWICPEAVDCTVKRETRKQIDNYSKDSQLLIHSVKVTDSGIYQCAAENKKGKTMTSVELQILERGFINISASENTTINVKAGESLTLTVEFEAYPRPENLYWMYEGEELQNASDHIIATEEDSYRYHSRLKLVRLRGSEGGNYTFFTSNSYAAVNQTFDVHVLSKPEIISQEGPINGQVRCVAAGYMAPEISWYSCKQPHVRCSDLPGATKETIEVSTITLPSSEFGKTEIASTLNISKLDFHTVECVAQIGNEQVYNLFSVNERIVQHELFTPLLTGFAAAAGGLCFILFILFYKYLQKPKYQIQWKVIEGINGNNYVYIDPSQLPYDQKWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTIMTVAVKMLKPRAHATEKEALMSELKVLSYLGHHMNIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRDMFFCSRLGDDSHYKNIQNKRGTENEESKNGYMTMRPSTAVPSLHSAPSEKRRLKRKGSYGDKDVSNDVLQEDTRSLDTEDLLSFSYQVAKGMNFLASKNCIHRDLAARNVLLTEGRVAKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFECVYTFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMIGPEFAPNEMYEIMKACWDTDPLQRPSFAKIVEMIELQLSDSTKHIYLNFSSKFSNIEELHSHFWRLNSVGSSTASTQPLLVGEDVVFEDEQRHQRV | 97 |
B6K069 | 4.6.1.16 | ACT_SITE 196; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 204; /evidence="ECO:0000256|PIRSR:PIRSR017250-50"; ACT_SITE 235; /evidence="ECO:0000256|PIRSR:PIRSR017250-50" | MPPYPIACLNGQYLLFDLEAVKEFRCKYGILGMLTGTLAQLPQQNVFLGLPVQLMNEEAYYLVKHGLAYLVDDVASHESTRAEITKYHVEQVHTQRRELAQEQHTENNRRQYEKKRLAMQKLGRPPPPEPSPAEDRRSDLLMVPVRTASNRELYAPQDSHIFPEVEMKRYHAFEYLLARKFCLNPGLRFGCHFVAYPGDSLRYHSHYLVNSYNWNEEVPVVNIIAGGRLGTGVKKAWLMCGTKSSSSKRNDTASTRCFSVEWAGFG | 207 |
A0A9J7LDP4 | 2.1.1.37 | ACT_SITE 1135; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MLGSGVLQRQPLSETLKAKLAELEEDFSDGNVTEKGYIKKRALLLNGLMTPDDHKLILKLDQELKNKSLPEKEYITEVTKVLDKYTAGSISQDSMECETSETNCSSSEETGENSKTVEACSSEDSGVLTSSGDEEKAPETGVKKSPKNIKQEKGSDDGVSPPKRRKGKLNGKGQPTIMSMFSKVPQKRKATDSGPEVDSSTDEGNNSESKVEHEDKKIKHEDNDMDADANGPELRKKETTCSPQKPKAPPVKCKECRQLLDDPDLRMFPGDPQEAVDEVEMLTDERLSLLEEDQEYGTYDDRPQHKITNFSVYDKNTHLCAFDTGLIEKNVELYFSGAVKPIYDENPSADGGVLAKNVGPINEWWTAGFDGGENALIGFTTAFAEYIVMQPSEAYAPFMDTMWEKIHMSKLVIEFLVNNQEAAYEDLLNKIQTTVPPQSLRVTSFSEESLLRHAQFVVEQVENFDLAGDADEAPLLTTPCMRALIKLAGVTLGKRRAGRSGIKQPRKVKAKPMRQTKATTTNLVCSIFDTFFKDQIQDDKAGGPRRRRCGVCEVCQQADCGTCVACKDMTKFGGTGKSKQACVNRRCPNMAVQDADDDDDIEDDLDKEFSSTVGHKRTHFSPRKKVNSKVKISWEGKPIKEEGKKTFYSAVMLEEEKIETGDCVTVTSEDPTKPLFIARVMYMWEDSGGDMMCHVGWFCRGSDTVLGETSDPLEVFLVDECEDILIQFVKFKCKVILKTFDKDWFSHGGVEDPDSDYPIKEDDGRTFFCQKWYDPDLARFEDPPVLEEGSGHKFCPLCLRLDHSRKSEIPIVGEQLDDTMGDDNKVYYSLCQKGGLEYKIGDDVFLLPDSFSFSVKVKNSTKKASKKDNYDEDLYPEYYRKRGDYVKGSNEECPEPFRIGRIISIYCKRTVSGIINTHDVRLRVTKFYRPENTHKGKAGSHHTDLNMLYWSDEEAVVDFMSVQGKCQVVYGEDLDVSVEDWSSKGLHRFYFNEAYNTESKQFEEPPNKARSGGKKAKGKGKGKGKGKGKSSEAESKEQQPPSPAFTKLRMLDVFAGCGGLSEGFHQAGIADSKWAVEVMEPAAQAYRLNNPDCTVFTDDCNILLKLVMEGATTNSTGQRLPQKGDVELLCGGPPCQGFSGMNRFNSRQYSQFKNSLVVSFLSYCDFYRPKFFLLENVRNFVSFKSSMVLKLTLRCLIRMGYQCTFGVLQAGNYGVAQTRRRAIILAAAPGEKLPMYPEPQHVFSPRACQLSVMVDEKKYNSNTQWRQSAPYRTITIRDTMSDLPSIRNGHSATEISYDGEPRSYFQKIIRGNQYQPILRDHICKDMNALVEARMRHVPLAPGSDWRDLPNIVVRLSDGSSSKLLQYTHEDKKNGTSSTGALRGVCSCAEGTACDQNDRQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRFYGSILDKHRQVGNAVPPPMAAAIGREIKKCLEDKAKKETQTGETKPVSMEA | 47 |
A0A3B3H9Z3 | 2.7.10.2 | ACT_SITE 332; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630220-1" | MCSSVLPHRLVPQKPDCLKDEAFTAAAFTPVAIQRIESSMRRFDKLKKSFPLLAHFHVYRRLGGSMQSEEGTEWLLELLMEVQLQQYFLRIQDDLNVTRLSHFDYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRPDGGEFPQQSQPASSFRKLSPTPPLCLGEGVLSTQSGGGTTLDVQQKALTCLISEKDLTLFEKLGDGSFGVVKRGEWMTPSGKLNVAVKCLKTDVLSQPDALEDFICEVNAMHSLDHQNLIRLYGVVLTHPMKMVTELAPLGSLLGRLRCLQGPILISTLCQYAVQVACGMAYLEQRRFIHRDLAARNILLASAQRVKIGDFGLMRALPNNHEHYVMQEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQILHKIDKEGERLPKPEDCPQDIYNVMLQCWAQKPDDRPTFVSLREFLLETLPTDMCALQDFDEPDKLQIKVNEVITVIEGRAENYWWRGQNKCTLQVGQFPRNVVTSVAGLSARDISRPLKNSFIHTGHGDTNPHRCWGHRDKIDDLYLGNPMDPPDVLGLELNAARPTQLPGRAKKPYYDLVTEEEDLASAALKRLSLRKTGSLKGLRLIPTVWISASKQGDCRTSSSGQNPNSEVSLIDFGEELSPPTPSPSPVVEAPIPALAKLALEAENILDKTPPESPSTSLPRPLHPTPVVDWDAKPLPPPPAYDEVAQDEDDMEVSSINGSDQHLEEESICVHNPNEAPFSRLRLQGEGIFSKEVDMESVEDNLFLPSQGSRGTSTSFSQSAEIFLELQRECMRRLNAPKGTLCHLPASPNSQTQDGPLFSSSGEDKPQIPPRVPIPPRPIWRADQTCARWSRELSVSPTDNSEGVAGSDPGRPPQIPPRDPLSQPASRTPSPMGLVVGSPQQRLHSASPPTQQALLSSCAAAHAYSSYLSTSPGKLMPTTHSFASDPKYAAPKVIQVQGKDKGPCILPIVRDGRKVSSTHYYLLPERPPYLDRFGHFLREAEHLPTSATDDRHVRHANTATVRPMVVSAQTVQGHTQGQSLLQAEDLKANFSSNNNSSLGGPQSEVKTSVSLPRVCSDGVTTAVIPASCLRADSGGNGPDKVKVVQEAVHGVTLEECQAALQNQNWSVQKAVHFLKVEQLFCLGLKSRSDCLKLLETCDWNLEVASTRMLENYGSTTWQGR | 98 |
B9REH3 | 3.2.1.21 | ACT_SITE 416; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU10055" | MAAQVAILLCCLVMIGGFLGSTYATTPGHYTMPFNRSSYPSGFIFGAGSAAYQSEGAAYIDGKGPSIWDTFTREHPEKIWDQSNGDVAIDFYHRYKEDIQLMKRIGLDSFRFSISWSRVLPKGKVSGGVNPKGVKFYNDLINELIANGLTPFVTLFHWDLPQALEDEYNGFLSPKVVDDYRDYADFCFKTFGDRVKHWCTLNEPYSFSINGYNGGTFAPGRCSNYVGNCTAGDSSTEPYLVAHHLLLSHASAVRLYKAKYQATQKGQIGVTLVTNWFIPKSPASESDKKATMRIIDFMFGWFAHPITYGDYPEIMKAYVGDRLPKFTKEQSKLLKGSLDYMGVNYYTTNFASNNPVTTSNHSWSTDSQTTLSVTKAGVPIGTPTPLNWLYVYPRGIYHLMLHIRDNYKNPPIFVTENGLADANNASISIEESRKDALRIRYYHTHLTNLLQAIK | 161 |
O35521 | 3.4.25.1 | ACT_SITE 21; /note="Nucleophile"; /evidence="ECO:0000250" | MLRAGAPTAGSFRTEEVHTGTTIMAVEFDGGVVVGSDSRVSAGAAVVNRVFDKLSPLHQRIFCALSGSAADAQAIADMAAYQLELHGLELEEPPLVLAAANVVKNISYKYREDLLAHLIVAGWDQREGGQVYGTMGGMLIRQPFTIGGSGSSYIYGYVDAAYKPGMTPEECRRFTTNAITLAMNRDGSSGGVIYLVTITAAGVDHRVILGDELPKFYGE | 180 |
A0A3B3HDF3 | 2.3.1.48 | ACT_SITE 452; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MPRRRQRAMAGSVSDGTEDSDSSAEREQTHSSESDGNMPKRQRLTRASTRLSQSSQDTPDLKRAADHDESPPLTPTGNAPSSESELDISSPNASHDESHTKDQASRDSDKDLSHRPKRRRCHETYNFNMKCPTPGCNSLGHLTGKHERHFAVSGCPLYHNLSADECKVKAISREKQEEEAKTQEENSSRHATRHQTPTPKQSKYKEQVAEMRKGRNAGQQKEQKEKHTEHRQTHGNTREPLLENITSEYDLELFRKAQARASEDLEKLRIQGQITEGNNMIKTIVFGRFELDTWYHSPYPEEYARLGRLYVCEFCLKYMKSQTILRRHMAKCVWKHPPGDEVYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLVGYFSKEKNSFLNYNVSCILTMPQYMRQGFGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYMCNFQGKEISIKEISQETAVNPVDIVSTLQSLQMLKYWKGKHLVLKRQVSRAGGGGGQKAEFYYNKRNWVPFSLKPGVPNMSKGSVGRSPAIENK | 61 |
P39967 | 3.4.19.12 | ACT_SITE 143; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 618; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MIKRWLSVNRKKSHPEKNTQGNDEINRKATSLKKTKGSGDPSIAKSPSAKSSTSSIPSNLASHERRSKFSSQTDNLAGNKHYHEHYHNMASTSDEREYDSSTTYEDRAFDTESSILFTTITDLMPYGDGSNKVFGYENFGNTCYCNSVLQCLYNIPEFRCNVLRYPERVAAVNRIRKSDLKGSKIRVFTNESFETSTNSGNSNTGYQSNDNEDAHNHHHLQQSDQDNSSSSTQEKQNNFERKRNSFMGFGKDKSNYKDSAKKDDNNEMERPQPVHTVVMASDTLTEKLHEGCKKIIVGRPLLKQSDSLSKASTTDCQANSHCQCDSQGSRITSVDDDVLVNPESCNDAVNNSNNNKENTFPTSEQRKKAALIRGPVLNVDHLLYPTEEATLYNGLKDIFESITENLSLTGIVSPTEFVKILKKENVLFNTMMQQDAHEFLNFLLNDFSEYIQRNNPRMRFGPQKTDNSNDNFITDLFKGTLTNRIKCLTCDNITSRDEPFLDFPIEVQGDEETDIQKMLKSYHQREMLNGVNKFYCNKCYGLQEAERMVGLKQLPHILSLHLKRFKYSEEQKSNIKLFNKILYPLTLDVSSTFNTSVYKKYELSGVVIHMGSGPQHGHYVCICRNEKFGWLLYDDETVESIKEETVLQFTGHPGDQTTAYVLFYKETQADKTENQNENIDTSSQDQMQTDNNIEQLIKCDDWLRDRKLRAAANIERKKTLGNIPEVKTAETKTPLNDKKRNKQKRKSRILSFIK | 175 |
Q7XSK0 | 3.2.1.21 | ACT_SITE 194; /note="Proton donor"; /evidence="ECO:0000269|PubMed:33471829, ECO:0007744|PDB:7D6B"; ACT_SITE 408; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:33471829, ECO:0007744|PDB:7D6B" | MAGGSKTRIHASLVSTLLLLLPLASAIHRSDFPASFLFGTATSSYQIEGAYLEGNKSLSNWDVFTHLPGNIKDGSNGDIADDHYHRYEEDVELMNSLGVNAYRFSISWSRILPKGRFGGVNPAGIDFYNKLIDSILLKGIQPFVTLTHYDIPQELEDRYGAWLNAEIQSDFGHFADVCFGAFGDRVKYWTTFNEPNVAVRHGYMLGTYPPSRCSPPFGHCARGGDSHAEPYVAAHNVILSHATAIEIYKRKYQSKQRGMIGMVLYSTWYEPLRDVPEDRLATERALAFETPWFLDPLVYGDYPPEMRQILGGRLPSFSPEDRRKLRYKLDFIGVNHYTTLYARDCMFSDCPQGQETQHALAAVTGESNGLPIGTPTAMPTFYVVPDGIEKMVKYFMRRYNNLPMFITENGYAQGGDSYTDAEDWIDDEDRIEYLEGYLTKLAKVIRDGADVRGYFAWSVVDNFEWLFGYTLRFGLYYIDYRTQERSPKLSALWYKEFLQNLHENQ | 161 |
Q5B135 | 4.2.1.11 | ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000250"; ACT_SITE 347; /note="Proton acceptor"; /evidence="ECO:0000250" | MPISKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEAHELRDGDKSKWLGKGVLTAVKNVNETIGPAVIKENLDVKEQSKIDEFLNKLDGTPNKSNLGANAILGVSLAIAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPDTASSFSEGLRQGAEVYHKLKALAKKKYGQSAGNVGDEGGVAPDIQTAEEALDLITEAIEQAGYTGKIHIAMDVASSEFYKPEEKKYDLDFKNPDSDPSKWLTYEQLADLYKSLAAKYPIVSIEDPFAEDDWEAWSYFYKTSDFQIVGDDLTVTNPLRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTIADISVGLRSGQIKTGAPARSERLAKLNQILRIEEELGENAVYAGQNFRKSVNL | 200 |
A0A059DEL4 | 2.3.2.26 | ACT_SITE 1528; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MGSRGQKRTEVVEDFPADKRACSSLDFRPSSSSLPMENQVESTSSRLESHETDMDTASTASASSHSEGEPEKDSTCGSCDSDDVDPRYGGLREYHRSRSFGDHSKFKKILSSLTEETEPSGQLAVLTELCEVLSFCTEDSLSSMLADAFSPILVKLARHESNPDIMLLASRAITYLCDVFPRSSALLVRHDAVPAICQRLMAIEYLDVAEQCLQALEKISRDQPLACLEAGAIVAVLNFIEFFSTSVQRVALSVVANICKKLPSDCPSLFMDAVPSLCNLLQFEDQQLVESVAFCLTKITERVSQNPEKLDELCKHGMINQALRLINLNSGTTLSLPVYNGIIGMLVKLSSGSYLGFRTLYELNVCIILKDILATYDVPHGVSSPRLADGHGIQVQEVLKLLYELLPSLANNEDFQQVSEKGAFLCSNPGFLRMFGVDILPLLIQMVNSGANIRVCYGCIIIINNLLSLSTSDILAEVLTNSNFSSFLAGVFTRKDHHVLDIALQIAESSLRKLGDMCLKSFIKEGVFFAIDALITPEKCSHRLFPVFSGNQLSVDSSQKPANKGVLRCLCYAFENDHSPSASETRTCKLALDTIHQRAKDIKTSFFSPELCDSEEALTDILQMLKTLATSINDLMNKPVDESSLQHEEKFHSILHQIAVKLNGSEPISTFEFIESGVVKSLVNYLSNGLSTSDEVELDDKVGHLLVIEKRLRVFGRLVFTALDSLHGDLPMVILIRKLQSALSSLENFPVIINNSTKQRNSFAMVPNGRCVSHPCLRVHFVKGEGEESLCDYSQDVLTVDPFTPLNAIERFLYPKVKKSEHVEKNALVEQQNLPLKLPINANLTCGESSKHMEFHGMSTALQDLQQGEANLSKSIHDQPDVGQQSNPGETSDEQDCAVSQSKAPEPDINGSTQSPSSEDDNPSPKLLFYLDGQQIDRTLSLYQVFLQQQIKVGNETIASAKLWSQVFTLTYKRAAEPRQEYSQECPFSARNLPLLDKKGVHMQGIPCFSYLFAGKLVSNLEKPSPVYDIIVLLKSMEAMNRRAFQLMSMERMAAFAEGRMDNLDDLKFMAPLVLQNEFVSSKLTEKIEQQMRDSLAVSTGGMPSWCNQLMDSCPFLFSFEARRKYFHLSAFGQLQIQSDPSSHGSTGSSTDRRRSASSLVRKKFLVHRDRIMDSAIQMMDLYARQRVALEVEFDDEVGTGLGPTLEFYTLISHEFQKPGLGMWREDHGSFSSNKVMETHGSEMILSPFGLFPCPWAPALCTSENVEFAEVINRFILLGKLVAKALQDGRVLDLHLSKAFYKLIIGQDLTLYDIPSFDPELGRTLLEFQALVDRKRFLESVHGESSTLRNDLCFRNIAMEDLCLDFTVPGYTNYVLSSGPDHKMVNMTNLEDYVSFVVDATTNSGISRQVEAFKSGFNQVFPIKNLQIFSEDELERLLCGENNSWEFSELLEHVKFDHGYTASSTPVIYLLETIQEFDREQQRSFLQFVTGAPRLPSGGLASLNPKLTIVRKHCSKSADAELPSVMTCANYLKLPPYSSKEKMKEKILYAIREGQGSFHLS | 65 |
A0A0D1CPG7 | 3.1.3.1 | ACT_SITE 142; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MDLDSKLPRPASAVDSSARRHRAQETSSQRYIRLRAAAYLSNVFKAALLLLTLLALHRESFDYVSDIASGVWHWPWSPRPVKTNIILMISDGYGPASLTFTRHFAQALNNDTDSESPFQLPLDTILVGTHRSRSSSSLITDSAAGATAFSCAKKSYNGAIGVTSDGNACGTVFEAAKRKGLLTGVVVTSRLTDATPAAFISHAASRAEEPLIASQMIGGNKNPLGQRTLDLAIGGGGCAFLPNSTIVSCRQDDEDTVEYAKQLGWDVRLAFPSNTSADSLYSQLHSSDELFGTASGRSKPQLPFMALLAPVNTPYEIDRVNIPAPLPLKPLSHYASKALELLSTSDQNDKGFILMIEGSQIDLCAHNNDPACHAREALAYHDTIALVKQFVDQHNSKSERTLLISTSDHETGGVTLGRQLSLDYPNYAYYPERLLNAKHSTPILTAVLIDFVRSETGKVASRDGKVSESLVRHFIRDKILGESGLGFSGKVQGGKPTEVEIEAVWKVVKDEILTVQDESTLYQASAYLRQSHNTAHRADGISRSLNWMGPVPGVNLDGIRRVISDIAARRAEIGFSTSGHTGIDINVYAYGAETHRLVGNQDNTNIGVVIKDILALDLEAVTRDLNKS | 141 |
H3GA50 | 2.3.2.26 | ACT_SITE 341; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MAASALLVPAEREHLRLNVERASVFKDSMESLAIIPLQNARSVVRINFLDENGVDAGGLQREWFVMLNEALVDPVRGLFVCANKRDQTYYMSPCSDMELLPNQLLNLFAAGRLLGRALLEGSMLCFHLASPFLKLILGYPLSFEDLEDLDPEVYSNLRWLLENDNVDALDLDFTVTTKDGDSYRDIELVPGGSAIPVTDSNKREFVELKWQYLLVESVAPQLQVFLQGLYEIVPRELLLLFDPEEFDFLLCGSDEIDVDDWERNTKYSEDLHHHRSLKWFWELVREMPNEYRRRLLQFSTGSSRVPLGGFSALTSYDGRLCPFTLKAVSLIGDGFIHSHACFNRLDLPLHVVRDELKAVLYAVLETEVYGFTTD | 65 |
Q7S2Z9 | 5.3.1.1 | ACT_SITE 95; /note="Electrophile"; /evidence="ECO:0000250"; ACT_SITE 165; /note="Proton acceptor"; /evidence="ECO:0000250" | MARKFFVGGNFKMNGTRKDLKAIVDNLNNAQLDPNAEVVIAPPALYLDFVKQNLQKPNVEVAAQNVFNKPNGAFTGEISATQLLDLGVKWVILGHSERRNELGESDEFIASKTKYALDNGISVIWCCGESKDTRQAGETIKFVENQLAALAKEINDWKNVVIAYEPIWAIGTGLVATKEQAQEVHAAIRSWLKQNVSDKVAEETRILYGGSVNAKNCKDLAKEQDIDGFLVGGASLKPEFVDIINANL | 213 |
A0A2K1WW45 | 3.1.1.11 | ACT_SITE 411; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSSDNHNTLKNKKRLFLSLFSSILLVTAIVSIVAGVTSSKNSTESNNDHQVAHTILKSSCSSTLYPHLCFSALSAVPDATSKIKSKKDVIDLSLNRTMSATRHSYFKIQKLTSTRRSFTERENTALHDCLVMLNETLDQLSKAYQELQDYPSLKKSLSVHADDLKILLSAAMTNQETCLDGFSHDKADKKVRELFIDEEMHVYHMSSIALAIIKNVTDTDMAKEQSLSSGRKLEEENGTEWPEWLSAGDRRLLQATTVTPNVVVAADGSGNYRTVSEAVAAAPERSSSRYIIRIKAGVYRENVDVPRSKTNIMFMGDGRTTTIITASRNVVDGSTTFNSATVAAVGDGFLARDITFQNSAGPSKHQAVAIRVGSDLSAFYRCDMIAYQDTLYVHSLRQFYVSCIIIGSVDFIFGNAAVVFQDCDIHARRPNPGQKNMVTAQGRSDPNENTGIVIQKCRIGATQDLLAAKSSFRSYLGRPWKLYSRTIVMQTEISDIIDPAGWFEWDGDFALDTLVYREYQNTGPGANTANRVNWKGFKVVTSAIEVQPFIARNFIRGASWLPSTGFPYSFDL | 125 |
A0A022RW71 | 3.1.1.11 | ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAANKVAIFGLIATLAVAGAVAAAIILAGNTNTKTTKDQTNNISTSQKAIQDLCQSTYYQQTCTETLSNATNSSDPQTLIQTIFEIAISHLNNTIQQSGPLQQISNDPKTSQAYKTCTKVLDDSIQDLRKTIHRTETFDFFDFSIFIDDIKTWLTGALTYQETCLDSFEDTKGDHAETMRQLLKLSRELTTNGLAIANQIHRLFLPNLLAPPVAPTKHQLADRKPLSPRGDSNYYRKLLQMASDRRYDTPNVVVAKDGSGKYKTVTEALKEVPERSNETFVIHVKEGVYEEYVEITSGMWSVVLVGDGPTKTRITGKKSYGGDGLGTYFTATVGIDGDNFIGKDIGFENTAGAIGYQAVALRVSADKAIFYNCHIDGYQDTLYAHNHRQYYRDCTISGTIDFIFGNARALIQNCTLLVRKPLDNQACVVTANGRTLSNETSAFVIHGSRVVAAPEYPVDDKRIQSFLGRPWKEYSKTIFMASEIEGFISPEGWSPWDNTADHLDTCWYAEVGNRGPGADLTNRVKWPGIKNITMAEAAQFAPTMYMDSGHWIEGKGIPFDSVLEMVIKN | 125 |
W1PQ18 | 3.1.3.48 | ACT_SITE 47; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 49; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MAENLEPLEPEVKRIKREDNSMGTNVLLSDAQDAAAVNEKRTVFVWDMDETLILLKSLLDGTYGKSCDGAKDIEKGVEIGKCWEKHILQVCDEYFFYEQIEEFNEPFVDSLSEYDDGRDLSAYDFSKDGFSQPCDDANKRKLAYRYRVIAQKYAQGLHCVLDQETLKLWDDLYDLTDDFTDKWLSSARALLEQCLEGDFFSSSASFHSSSTTSSCHKKGEKVNVLVTSGSLVPSLVKCLLFRLNGSIPYDNVYSSWDVGKLQCFSWIKERFGSTASQFCVIGNGSEECEAAKAMGWPFVMIDLQPGCWHRFPGLSLKTIKQYIDVVYPEETKDES | 149 |
A0A0P0VIP0 | 2.7.11.1 | ACT_SITE 514; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MPPRCRRLPLLFILLLAVRPLSAAAASSIAAAPASSYRRISWASNLTLLGSASLLPGAAGVALTTPSRDGVGAGRALFSEPVRLLLPQDAAASASASRAATPASFSTRFTFRITPSPTYGDGLAFLLTSSRTFLGASNGFLGLFPSSSASDEGELRDVSTVAVEIDTHLDVALHDPDGNHVALDAGSIFSVASAQPGVDLKAGVPITAWVEYRAPRRRLNVWLSYSPSRRPEKPALSADVDLSGLLRTYMYAGFSASNGNGAALHVVERWTFRTFGFPNSSYAPPPTKYIGPMPPNNQPLPPPPSPSPSPPPPSPPPPPHPNHRRRHLFYKVLGGVLGGMVLLGLVVVGSAVLLGRSVRRKNQEHAVASEDMGEATLSMEVARAATKGFDSGNVIGVGGSGATVYEGVLPSGSRVAVKRFQAIGSCTKAFDSELKAMLNCPHHPNLVPLAGWCRSKDELVLVYEFMPNGNLDSALHTLGGATLPWEARFRAVYGVASALAYLHDECENRIIHRDVKSSNVMLDAEFNARLGDFGLARTVSHGGLPLTTQPAGTLGYLAPEYVHTGVATERSDVYSFGVLALEVATGRRPAERGISVVNWVWTLWGRRRLVDAADRRLQGRFVADEMRRVLLVGLCCVHPDCRKRPGMRRVVSMLDGTAPLILVPDKMPPVLLQPVPNASSMNSADTANTAFFSCR | 99 |
Q758T2 | 2.7.11.1 | ACT_SITE 190; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSAWASQEAAKEEEAVGDFARMLERRDAGLLARVLSRAQTGPEAYVRGLWRAEVGLERWRLTRVLGCGSVACVFELGDGALALKVPTSRRKAPVLLHEVLIYSHLAQQAGGRLAERHVVPFHGVAAVTRREYRRLRGGEVVPALVLERMDTTLEAVHRRAAVSKGQWWRYARDLVAALQFLRESCVVHGDIKTANVLVRGQDAFLADFTSAAVCDAAPEPLTTTLEYCAPGLIGGGQPTHSTDVYAAGLCLLALITRFEPFRELSMMKSHSSAPTHSLHETQWLMNAISKGDPIKYNVLSQDLYDRWAEELHFLRRFFVPAAQDALSRWLAESNARVAEHAF | 99 |
Q5KAN4 | 2.7.1.11 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03184" | MSDSPAATPLPKDPEGITEQIQSVSTPPPPPQAQKPARQKKIAVLTSGGDSAGMNAAVRAIVRQSIARGCQAYIIREGWEGLVRGNTSGPTPAPTAPQSPTLSASSKTVTFSSLPPSQQFDKLTSTLNKESLANEVSFSDPNEVTPLEDTPLSFGYGQLLRDGAGEGDVEELASHGMQGLAIADREDEKGRSLKNKYIVRVGWDDVRGWQGEGGTLIGSSRCPAFRTREGRLQAASNLIHSGIDCLAVCGGDGSLTGADKLRGEWPSLVEELYTENKITDDQREAYHHLNIVGLVGSIDNDMALTDLTIGALTALHRICESIDSISSTASSHSRAFVIEVMGRHCGWLALLAGIATGADFIFIPEDPPKCEDWETEMCDLLQAHRKVGKRKSIVIVAEGALDRNLKPIKPDYVKKILVERLGLDTRVTTLGHTQRGGKPCAFDRILPTLQGVEAVQTLLSATPETPSYMIGIQENKITKIPLLEAVARTQMVAEAIENRDFAKAMSFRDSEFREMLQAFQISSSLDVSQNAPVDKRLRIGIIHVGAPAGGMNAATRQAVRFCHNRGHVPVAIYNGFEGLLDDNVSELSWLRVDSWTTRGGSELGTNRSLPSIDIGSVAAGFQRYSLDALLVIGGFEAFHSVVLLSQNRTNYPAFQIPIVHLPATLSNNVPLTDFSLGSDTSLNALVEACDAIKQSASASRNRVFVVETQGGMSGYIATMGALAVGAVLVYTPENGISLKLLQEDVEFLIKRYKLDEKGKSEGRLVIKAEKSSSVYTTETLTKIFKEEGKDLFDARSASLGHTLQGGVPSPLDRTRAARLSLRCMQFLEEHASPNSQASHHKPKSAAHPHAGAKSIAKDTAAMIAIIGSKVVYATMDDVLKVTDMKLRRGTDEWWSDCKELAETMGGRTGLMAKH | 84 |
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