aymangomaa/entity_extraction_ade_v2_chat_base

The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.

[ { "ade": "nephrotoxicity", "drug": "mannitol" }, { "ade": "ARF", "drug": "mannitol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed.", "role": "user" }, { "content": "[{\"ade\": \"nephrotoxicity\", \"drug\": \"mannitol\"}, {\"ade\": \"ARF\", \"drug\": \"mannitol\"}]", "role": "assistant" } ]

Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.

[ { "ade": "adrenal insufficiency", "drug": "Rifampicin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Rifampicin-induced adrenal insufficiency in the acquired immunodeficiency syndrome: difficulties in diagnosis and treatment.", "role": "user" }, { "content": "[{\"ade\": \"adrenal insufficiency\", \"drug\": \"Rifampicin\"}]", "role": "assistant" } ]

After discontinuation of danazol the diabetes completely resolved.

[ { "ade": "diabetes", "drug": "danazol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: After discontinuation of danazol the diabetes completely resolved.", "role": "user" }, { "content": "[{\"ade\": \"diabetes\", \"drug\": \"danazol\"}]", "role": "assistant" } ]

46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.

[ { "ade": "reticulate erythema", "drug": "interferon beta-1b" }, { "ade": "painful ulcers", "drug": "interferon beta-1b" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: 46-year-old woman developed painful ulcers over her lower abdomen in the form of reticulate erythema after injecting interferon beta-1b subcutaneously for multiple sclerosis.", "role": "user" }, { "content": "[{\"ade\": \"reticulate erythema\", \"drug\": \"interferon beta-1b\"}, {\"ade\": \"painful ulcers\", \"drug\": \"interferon beta-1b\"}]", "role": "assistant" } ]

PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.

[ { "ade": "myoclonus", "drug": "dobutamine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: PURPOSE: The occurrence of myoclonus associated with continuous i.v. infusion of dobutamine in a patient with end-stage renal disease (ESRD) is described.", "role": "user" }, { "content": "[{\"ade\": \"myoclonus\", \"drug\": \"dobutamine\"}]", "role": "assistant" } ]

Hypersensitivity to zonisamide was confirmed by the skin patch test.

[ { "ade": "Hypersensitivity", "drug": "zonisamide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hypersensitivity to zonisamide was confirmed by the skin patch test.", "role": "user" }, { "content": "[{\"ade\": \"Hypersensitivity\", \"drug\": \"zonisamide\"}]", "role": "assistant" } ]

Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.

[ { "ade": "duodenal ulceration", "drug": "Tolazoline" }, { "ade": "intestinal perforation", "drug": "Tolazoline" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation.", "role": "user" }, { "content": "[{\"ade\": \"duodenal ulceration\", \"drug\": \"Tolazoline\"}, {\"ade\": \"intestinal perforation\", \"drug\": \"Tolazoline\"}]", "role": "assistant" } ]

Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.

[ { "ade": "bleeding symptoms", "drug": "warfarin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Despite the low dosage of warfarin, international normalized ratio (INR) was markedly elevated from 1.15 to 11.28 for only 4 days, and bleeding symptoms concurrently developed.", "role": "user" }, { "content": "[{\"ade\": \"bleeding symptoms\", \"drug\": \"warfarin\"}]", "role": "assistant" } ]

We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.

[ { "ade": "pericardial effusion", "drug": "clozapine" }, { "ade": "pericarditis", "drug": "clozapine" }, { "ade": "polyserositis", "drug": "clozapine" }, { "ade": "pleural effusion", "drug": "clozapine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the case of a patient who developed polyserositis (pericardial effusion, pleural effusion, and pericarditis) after being started on clozapine, and whose symptoms remitted upon discontinuation of clozapine.", "role": "user" }, { "content": "[{\"ade\": \"pericardial effusion\", \"drug\": \"clozapine\"}, {\"ade\": \"pericarditis\", \"drug\": \"clozapine\"}, {\"ade\": \"polyserositis\", \"drug\": \"clozapine\"}, {\"ade\": \"pleural effusion\", \"drug\": \"clozapine\"}]", "role": "assistant" } ]

Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.

[ { "ade": "inflammatory arthritis", "drug": "IFN-beta" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Our literature review revealed an additional six cases of onset of inflammatory arthritis in MS patients receiving IFN-beta.", "role": "user" }, { "content": "[{\"ade\": \"inflammatory arthritis\", \"drug\": \"IFN-beta\"}]", "role": "assistant" } ]

Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.

[ { "ade": "methanol poisoning", "drug": "methanol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.", "role": "user" }, { "content": "[{\"ade\": \"methanol poisoning\", \"drug\": \"methanol\"}]", "role": "assistant" } ]

Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.

[ { "ade": "hepatic impairment", "drug": "propylthiouracil" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.", "role": "user" }, { "content": "[{\"ade\": \"hepatic impairment\", \"drug\": \"propylthiouracil\"}]", "role": "assistant" } ]

A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.

[ { "ade": "trichiasis", "drug": "prostaglandin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog.", "role": "user" }, { "content": "[{\"ade\": \"trichiasis\", \"drug\": \"prostaglandin\"}]", "role": "assistant" } ]

Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.

[ { "ade": "hepatocellular injury", "drug": "isradipine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity.", "role": "user" }, { "content": "[{\"ade\": \"hepatocellular injury\", \"drug\": \"isradipine\"}]", "role": "assistant" } ]

We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.

[ { "ade": "pancytopenia", "drug": "5-aminosalicylic acid" }, { "ade": "pancytopenia", "drug": "Pentasa" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of pancytopenia in a 23-year-old man with Crohn's disease who was treated with 5-aminosalicylic acid (Pentasa; Nisshin, Tokyo, Japan) 3.0 g/day.", "role": "user" }, { "content": "[{\"ade\": \"pancytopenia\", \"drug\": \"5-aminosalicylic acid\"}, {\"ade\": \"pancytopenia\", \"drug\": \"Pentasa\"}]", "role": "assistant" } ]

The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.

[ { "ade": "hypercortisolism", "drug": "CPH82" }, { "ade": "suppression of the endogeneous production of ACTH and cortisol", "drug": "CPH82" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.", "role": "user" }, { "content": "[{\"ade\": \"hypercortisolism\", \"drug\": \"CPH82\"}, {\"ade\": \"suppression of the endogeneous production of ACTH and cortisol\", \"drug\": \"CPH82\"}]", "role": "assistant" } ]

To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.

[ { "ade": "neurologic disease", "drug": "penicillamine" }, { "ade": "neurologic worsening", "drug": "penicillamine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.", "role": "user" }, { "content": "[{\"ade\": \"neurologic disease\", \"drug\": \"penicillamine\"}, {\"ade\": \"neurologic worsening\", \"drug\": \"penicillamine\"}]", "role": "assistant" } ]

A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.

[ { "ade": "acute hemoglobinemia", "drug": "anti-D IGIV" }, { "ade": "hemoglobinuria", "drug": "anti-D IGIV" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A previous review described data on 15 patients who experienced acute hemoglobinemia or hemoglobinuria following anti-D IGIV administration for ITP or secondary thrombocytopenia.", "role": "user" }, { "content": "[{\"ade\": \"acute hemoglobinemia\", \"drug\": \"anti-D IGIV\"}, {\"ade\": \"hemoglobinuria\", \"drug\": \"anti-D IGIV\"}]", "role": "assistant" } ]

These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.

[ { "ade": "renal disease", "drug": "gold" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: These findings are consistent with an immune-complex form of glomerulopathy in which gold is neither the antigen nor a hapten in the glomerular deposits, and they suggest the hypothesis that antibodies to tubular epithelial antigens induced by gold therapy may be a causative factor in the renal disease associated with gold therapy in rheumatoid arthritis.", "role": "user" }, { "content": "[{\"ade\": \"renal disease\", \"drug\": \"gold\"}]", "role": "assistant" } ]

Nabumetone-associated interstitial nephritis.

[ { "ade": "interstitial nephritis", "drug": "Nabumetone" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Nabumetone-associated interstitial nephritis.", "role": "user" }, { "content": "[{\"ade\": \"interstitial nephritis\", \"drug\": \"Nabumetone\"}]", "role": "assistant" } ]

Protamine allergy as a complication of insulin hypersensitivity: A case report.

[ { "ade": "Protamine allergy", "drug": "insulin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Protamine allergy as a complication of insulin hypersensitivity: A case report.", "role": "user" }, { "content": "[{\"ade\": \"Protamine allergy\", \"drug\": \"insulin\"}]", "role": "assistant" } ]

Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.

[ { "ade": "anicteric hepatitis", "drug": "aspirin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Two children with rheumatic fever developed anicteric hepatitis while on high-dose aspirin therapy.", "role": "user" }, { "content": "[{\"ade\": \"anicteric hepatitis\", \"drug\": \"aspirin\"}]", "role": "assistant" } ]

With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.

[ { "ade": "herpes esophagitis", "drug": "Cyclosporine A" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: With the increasing use of Cyclosporine A in transplant patients, the incidence of herpes esophagitis may increase.", "role": "user" }, { "content": "[{\"ade\": \"herpes esophagitis\", \"drug\": \"Cyclosporine A\"}]", "role": "assistant" } ]

CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.

[ { "ade": "corneal ulcers", "drug": "moxifloxacin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: These cases suggest that moxifloxacin may interfere with the healing of corneal ulcers.", "role": "user" }, { "content": "[{\"ade\": \"corneal ulcers\", \"drug\": \"moxifloxacin\"}]", "role": "assistant" } ]

Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.

[ { "ade": "reserpine toxicity", "drug": "reserpine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Finally, reserpine toxicity, in particular central nervous system (CNS) disturbances, was reported more frequently in patients also receiving barbiturates, suggesting additive CNS effects.", "role": "user" }, { "content": "[{\"ade\": \"reserpine toxicity\", \"drug\": \"reserpine\"}]", "role": "assistant" } ]

Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.

[ { "ade": "ascites", "drug": "MTX" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.", "role": "user" }, { "content": "[{\"ade\": \"ascites\", \"drug\": \"MTX\"}]", "role": "assistant" } ]

Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.

[ { "ade": "optic neuropathy", "drug": "ethambutol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Since ethambutol is actively excreted via the renal system, compromise of renal function such as due to renal tuberculosis may lead to serum concentration elevations of ethambutol sufficient to produce optic neuropathy.", "role": "user" }, { "content": "[{\"ade\": \"optic neuropathy\", \"drug\": \"ethambutol\"}]", "role": "assistant" } ]

Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.

[ { "ade": "Motor fluctuations", "drug": "levodopa" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Motor fluctuations appear after 2-3 years of levodopa treatment, and affect at least 50% of patients after five years.", "role": "user" }, { "content": "[{\"ade\": \"Motor fluctuations\", \"drug\": \"levodopa\"}]", "role": "assistant" } ]

over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.

[ { "ade": "uveitis", "drug": "rifabutin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: over the past 3 years there have been several reports of uveitis associated with rifabutin therapy.", "role": "user" }, { "content": "[{\"ade\": \"uveitis\", \"drug\": \"rifabutin\"}]", "role": "assistant" } ]

We describe a patient who became hypothyroid while taking ferrous sulfate.

[ { "ade": "hypothyroid", "drug": "ferrous sulfate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a patient who became hypothyroid while taking ferrous sulfate.", "role": "user" }, { "content": "[{\"ade\": \"hypothyroid\", \"drug\": \"ferrous sulfate\"}]", "role": "assistant" } ]

METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.

[ { "ade": "intense conjunctival hyperemia", "drug": "bimatoprost" }, { "ade": "cystoid macula edema", "drug": "bimatoprost" }, { "ade": "cystoid macula edema", "drug": "latanoprost" }, { "ade": "intense conjunctival hyperemia", "drug": "latanoprost" }, { "ade": "cystoid macular edema", "drug": "bimatoprost" }, { "ade": "cystoid macular edema", "drug": "latanoprost" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: METHODS: A 68-year-old man developed intense conjunctival hyperemia and cystoid macula edema after switching from latanoprost to bimatoprost 9 months after cataract surgery in an eye at low-risk for this cystoid macular edema.", "role": "user" }, { "content": "[{\"ade\": \"intense conjunctival hyperemia\", \"drug\": \"bimatoprost\"}, {\"ade\": \"cystoid macula edema\", \"drug\": \"bimatoprost\"}, {\"ade\": \"cystoid macula edema\", \"drug\": \"latanoprost\"}, {\"ade\": \"intense conjunctival hyperemia\", \"drug\": \"latanoprost\"}, {\"ade\": \"cystoid macular edema\", \"drug\": \"bimatoprost\"}, {\"ade\": \"cystoid macular edema\", \"drug\": \"latanoprost\"}]", "role": "assistant" } ]

There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.

[ { "ade": "thrombocytopenia", "drug": "heparin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children.", "role": "user" }, { "content": "[{\"ade\": \"thrombocytopenia\", \"drug\": \"heparin\"}]", "role": "assistant" } ]

Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.

[ { "ade": "seizures", "drug": "CBZ" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Continuous EEG monitoring is helpful in managing seizures that occur as a complication of CBZ OD, after the course of recovery or worsening, and in providing assistance with prognosis.", "role": "user" }, { "content": "[{\"ade\": \"seizures\", \"drug\": \"CBZ\"}]", "role": "assistant" } ]

We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.

[ { "ade": "seizures", "drug": "ofloxacin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe four patients who had seizures while receiving ofloxacin; no other causes were evident.", "role": "user" }, { "content": "[{\"ade\": \"seizures\", \"drug\": \"ofloxacin\"}]", "role": "assistant" } ]

In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.

[ { "ade": "subcutaneous changes", "drug": "glatiramer acetate" }, { "ade": "localized panniculitis", "drug": "glatiramer acetate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In this article, we describe another case of subcutaneous changes following repeated glatiramer acetate injection, presented as localized panniculitis in the area around the injection sites, in a 46-year-old female patient who was treated with glatiramer acetate for 18 months.", "role": "user" }, { "content": "[{\"ade\": \"subcutaneous changes\", \"drug\": \"glatiramer acetate\"}, {\"ade\": \"localized panniculitis\", \"drug\": \"glatiramer acetate\"}]", "role": "assistant" } ]

Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.

[ { "ade": "alterations in heart rate", "drug": "adenosine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Life-threatening alterations in heart rate after the use of adenosine in atrial flutter.", "role": "user" }, { "content": "[{\"ade\": \"alterations in heart rate\", \"drug\": \"adenosine\"}]", "role": "assistant" } ]

The most common complication of warfarin use is adverse bleeding.

[ { "ade": "bleeding", "drug": "warfarin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The most common complication of warfarin use is adverse bleeding.", "role": "user" }, { "content": "[{\"ade\": \"bleeding\", \"drug\": \"warfarin\"}]", "role": "assistant" } ]

We report here a rare case of pleuropericarditis due to methotrexate.

[ { "ade": "pleuropericarditis", "drug": "methotrexate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report here a rare case of pleuropericarditis due to methotrexate.", "role": "user" }, { "content": "[{\"ade\": \"pleuropericarditis\", \"drug\": \"methotrexate\"}]", "role": "assistant" } ]

Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.

[ { "ade": "lethargy", "drug": "valproic acid" }, { "ade": "Hyperammonemia", "drug": "valproic acid" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.", "role": "user" }, { "content": "[{\"ade\": \"lethargy\", \"drug\": \"valproic acid\"}, {\"ade\": \"Hyperammonemia\", \"drug\": \"valproic acid\"}]", "role": "assistant" } ]

Terlipressin-induced ventricular arrhythmia.

[ { "ade": "ventricular arrhythmia", "drug": "Terlipressin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Terlipressin-induced ventricular arrhythmia.", "role": "user" }, { "content": "[{\"ade\": \"ventricular arrhythmia\", \"drug\": \"Terlipressin\"}]", "role": "assistant" } ]

Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.

[ { "ade": "Hepatotoxicity", "drug": "erlotinib" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hepatotoxicity resolved once erlotinib was discontinued and serum transaminases returned to baseline normal values.", "role": "user" }, { "content": "[{\"ade\": \"Hepatotoxicity\", \"drug\": \"erlotinib\"}]", "role": "assistant" } ]

In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.

[ { "ade": "SIADH", "drug": "mizoribin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.", "role": "user" }, { "content": "[{\"ade\": \"SIADH\", \"drug\": \"mizoribin\"}]", "role": "assistant" } ]

Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.

[ { "ade": "neoplastic seeding", "drug": "ethanol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Long-term follow-up after neoplastic seeding complicating percutaneous ethanol injection for treatment of hepatocellular carcinoma.", "role": "user" }, { "content": "[{\"ade\": \"neoplastic seeding\", \"drug\": \"ethanol\"}]", "role": "assistant" } ]

Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.

[ { "ade": "Pleuropulmonary fibrosis", "drug": "pergolide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Pleuropulmonary fibrosis after long-term treatment with the dopamine agonist pergolide for Parkinson Disease.", "role": "user" }, { "content": "[{\"ade\": \"Pleuropulmonary fibrosis\", \"drug\": \"pergolide\"}]", "role": "assistant" } ]

We hypothesize that capecitabine-induced headache is vascular in nature.

[ { "ade": "headache", "drug": "capecitabine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We hypothesize that capecitabine-induced headache is vascular in nature.", "role": "user" }, { "content": "[{\"ade\": \"headache\", \"drug\": \"capecitabine\"}]", "role": "assistant" } ]

Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.

[ { "ade": "seizure", "drug": "IFN-alpha" }, { "ade": "neuropsychiatric symptoms", "drug": "IFN-alpha" }, { "ade": "Parkinsonism", "drug": "IFN-alpha" }, { "ade": "akathisia", "drug": "IFN-alpha" }, { "ade": "depressive disorders", "drug": "IFN-alpha" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Therapy with IFN-alpha may be associated with a number of neuropsychiatric symptoms, such as Parkinsonism, akathisia, seizure, and depressive disorders.", "role": "user" }, { "content": "[{\"ade\": \"seizure\", \"drug\": \"IFN-alpha\"}, {\"ade\": \"neuropsychiatric symptoms\", \"drug\": \"IFN-alpha\"}, {\"ade\": \"Parkinsonism\", \"drug\": \"IFN-alpha\"}, {\"ade\": \"akathisia\", \"drug\": \"IFN-alpha\"}, {\"ade\": \"depressive disorders\", \"drug\": \"IFN-alpha\"}]", "role": "assistant" } ]

PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.

[ { "ade": "glaucoma", "drug": "triamcinolone acetate" }, { "ade": "glaucoma", "drug": "corticosteroid" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.", "role": "user" }, { "content": "[{\"ade\": \"glaucoma\", \"drug\": \"triamcinolone acetate\"}, {\"ade\": \"glaucoma\", \"drug\": \"corticosteroid\"}]", "role": "assistant" } ]

This pattern is suggestive of renal toxicity due to tobramycin.

[ { "ade": "renal toxicity", "drug": "tobramycin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This pattern is suggestive of renal toxicity due to tobramycin.", "role": "user" }, { "content": "[{\"ade\": \"renal toxicity\", \"drug\": \"tobramycin\"}]", "role": "assistant" } ]

However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.

[ { "ade": "photosensitivity", "drug": "mequitazine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.", "role": "user" }, { "content": "[{\"ade\": \"photosensitivity\", \"drug\": \"mequitazine\"}]", "role": "assistant" } ]

A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.

[ { "ade": "PCNSL", "drug": "natalizumab" }, { "ade": "primary central nervous system lymphoma", "drug": "natalizumab" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.", "role": "user" }, { "content": "[{\"ade\": \"PCNSL\", \"drug\": \"natalizumab\"}, {\"ade\": \"primary central nervous system lymphoma\", \"drug\": \"natalizumab\"}]", "role": "assistant" } ]

We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.

[ { "ade": "seizure", "drug": "L-asparaginase" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.", "role": "user" }, { "content": "[{\"ade\": \"seizure\", \"drug\": \"L-asparaginase\"}]", "role": "assistant" } ]

Acute sensorineural hearing loss following intravenous ketoralac administration.

[ { "ade": "Acute sensorineural hearing loss", "drug": "ketoralac" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute sensorineural hearing loss following intravenous ketoralac administration.", "role": "user" }, { "content": "[{\"ade\": \"Acute sensorineural hearing loss\", \"drug\": \"ketoralac\"}]", "role": "assistant" } ]

Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.

[ { "ade": "Ischaemia", "drug": "diamorphine" }, { "ade": "Ischaemia", "drug": "methylphenidate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine.", "role": "user" }, { "content": "[{\"ade\": \"Ischaemia\", \"drug\": \"diamorphine\"}, {\"ade\": \"Ischaemia\", \"drug\": \"methylphenidate\"}]", "role": "assistant" } ]

This is the first report of UFT-induced scleroderma-like reaction.

[ { "ade": "UFT-induced scleroderma-like reaction", "drug": "UFT" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This is the first report of UFT-induced scleroderma-like reaction.", "role": "user" }, { "content": "[{\"ade\": \"UFT-induced scleroderma-like reaction\", \"drug\": \"UFT\"}]", "role": "assistant" } ]

Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.

[ { "ade": "Disseminated eruptive giant mollusca contagiosa", "drug": "efalizumab" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Disseminated eruptive giant mollusca contagiosa in an adult psoriasis patient during efalizumab therapy.", "role": "user" }, { "content": "[{\"ade\": \"Disseminated eruptive giant mollusca contagiosa\", \"drug\": \"efalizumab\"}]", "role": "assistant" } ]

PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.

[ { "ade": "cicatrical entropion", "drug": "dipivefrin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: PURPOSE: To report patients who presented to the oculoplastics department for repair of cicatrical entropion after topical use of dipivefrin.", "role": "user" }, { "content": "[{\"ade\": \"cicatrical entropion\", \"drug\": \"dipivefrin\"}]", "role": "assistant" } ]

Hepatic damage after danazol treatment.

[ { "ade": "Hepatic damage", "drug": "danazol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hepatic damage after danazol treatment.", "role": "user" }, { "content": "[{\"ade\": \"Hepatic damage\", \"drug\": \"danazol\"}]", "role": "assistant" } ]

We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.

[ { "ade": "worsening of Raynaud's phenomenon", "drug": "yohimbine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a patient with CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) who paradoxically experienced worsening of Raynaud's phenomenon when using yohimbine for ED.", "role": "user" }, { "content": "[{\"ade\": \"worsening of Raynaud's phenomenon\", \"drug\": \"yohimbine\"}]", "role": "assistant" } ]

However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.

[ { "ade": "liver failure", "drug": "MTX" }, { "ade": "death", "drug": "MTX" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, continued low-dose MTX led, in spite of normal liver tests, 8 years after the last biopsy to liver failure and death in 1 of our patients.", "role": "user" }, { "content": "[{\"ade\": \"liver failure\", \"drug\": \"MTX\"}, {\"ade\": \"death\", \"drug\": \"MTX\"}]", "role": "assistant" } ]

We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.

[ { "ade": "acute myocardial ischaemia", "drug": "venlafaxine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.", "role": "user" }, { "content": "[{\"ade\": \"acute myocardial ischaemia\", \"drug\": \"venlafaxine\"}]", "role": "assistant" } ]

Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.

[ { "ade": "Neurologic symptoms", "drug": "CAP" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Neurologic symptoms resolved after stopping CAP for 4 weeks in Patient A, with no recurrence after reinitiating CAP alone at 2000 mg/m2.", "role": "user" }, { "content": "[{\"ade\": \"Neurologic symptoms\", \"drug\": \"CAP\"}]", "role": "assistant" } ]

We report here a case of TEN after administration of ciprofloxacin.

[ { "ade": "TEN", "drug": "ciprofloxacin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report here a case of TEN after administration of ciprofloxacin.", "role": "user" }, { "content": "[{\"ade\": \"TEN\", \"drug\": \"ciprofloxacin\"}]", "role": "assistant" } ]

Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.

[ { "ade": "hypersensitivity pneumonitis", "drug": "Flecainide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Flecainide is a rare cause of hypersensitivity pneumonitis, and few cases have been reported.", "role": "user" }, { "content": "[{\"ade\": \"hypersensitivity pneumonitis\", \"drug\": \"Flecainide\"}]", "role": "assistant" } ]

Life-threatening cranial dystonia following trihexyphenidyl withdrawal.

[ { "ade": "cranial dystonia", "drug": "trihexyphenidyl" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Life-threatening cranial dystonia following trihexyphenidyl withdrawal.", "role": "user" }, { "content": "[{\"ade\": \"cranial dystonia\", \"drug\": \"trihexyphenidyl\"}]", "role": "assistant" } ]

Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.

[ { "ade": "herpesvirus infection", "drug": "cytarabine" }, { "ade": "herpesvirus infection", "drug": "cytosine arabinoside" }, { "ade": "herpesvirus infection", "drug": "Ara-C" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine (cytosine arabinoside; Ara-C) shortly before their death.", "role": "user" }, { "content": "[{\"ade\": \"herpesvirus infection\", \"drug\": \"cytarabine\"}, {\"ade\": \"herpesvirus infection\", \"drug\": \"cytosine arabinoside\"}, {\"ade\": \"herpesvirus infection\", \"drug\": \"Ara-C\"}]", "role": "assistant" } ]

The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.

[ { "ade": "coma", "drug": "5-FU" }, { "ade": "encephalopathy", "drug": "5-FU" }, { "ade": "neurologic symptoms", "drug": "5-FU" }, { "ade": "severe acute 5-FU reactions", "drug": "5-FU" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma.", "role": "user" }, { "content": "[{\"ade\": \"coma\", \"drug\": \"5-FU\"}, {\"ade\": \"encephalopathy\", \"drug\": \"5-FU\"}, {\"ade\": \"neurologic symptoms\", \"drug\": \"5-FU\"}, {\"ade\": \"severe acute 5-FU reactions\", \"drug\": \"5-FU\"}]", "role": "assistant" } ]

Ciprofloxacin-induced renal insufficiency in cystic fibrosis.

[ { "ade": "renal insufficiency", "drug": "Ciprofloxacin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Ciprofloxacin-induced renal insufficiency in cystic fibrosis.", "role": "user" }, { "content": "[{\"ade\": \"renal insufficiency\", \"drug\": \"Ciprofloxacin\"}]", "role": "assistant" } ]

A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.

[ { "ade": "rapidly progressive glomerulonephritis", "drug": "D-penicillamine" }, { "ade": "epithelial crescents", "drug": "D-penicillamine" }, { "ade": "hemoptysis", "drug": "D-penicillamine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g.", "role": "user" }, { "content": "[{\"ade\": \"rapidly progressive glomerulonephritis\", \"drug\": \"D-penicillamine\"}, {\"ade\": \"epithelial crescents\", \"drug\": \"D-penicillamine\"}, {\"ade\": \"hemoptysis\", \"drug\": \"D-penicillamine\"}]", "role": "assistant" } ]

We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.

[ { "ade": "acute hepatitis", "drug": "gliclazide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.", "role": "user" }, { "content": "[{\"ade\": \"acute hepatitis\", \"drug\": \"gliclazide\"}]", "role": "assistant" } ]

When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.

[ { "ade": "DAT became positive with anti-IgG and anti-C3d antiglobulins", "drug": "fludarabine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: When the patient was treated again with fludarabine nine months later, the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment.", "role": "user" }, { "content": "[{\"ade\": \"DAT became positive with anti-IgG and anti-C3d antiglobulins\", \"drug\": \"fludarabine\"}]", "role": "assistant" } ]

A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).

[ { "ade": "syncope", "drug": "isosorbide dinitrate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate (5 mg).", "role": "user" }, { "content": "[{\"ade\": \"syncope\", \"drug\": \"isosorbide dinitrate\"}]", "role": "assistant" } ]

We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.

[ { "ade": "hemorrhage", "drug": "aspirin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case in which hemorrhage occurred in an asymptomatic falx meningioma known beforehand, after the internal use of low-dose aspirin for 16 months.", "role": "user" }, { "content": "[{\"ade\": \"hemorrhage\", \"drug\": \"aspirin\"}]", "role": "assistant" } ]

In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.

[ { "ade": "asterixis", "drug": "CBZ" }, { "ade": "asterixis", "drug": "carbamazepine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage.", "role": "user" }, { "content": "[{\"ade\": \"asterixis\", \"drug\": \"CBZ\"}, {\"ade\": \"asterixis\", \"drug\": \"carbamazepine\"}]", "role": "assistant" } ]

Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.

[ { "ade": "colitis", "drug": "cisplatin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin.", "role": "user" }, { "content": "[{\"ade\": \"colitis\", \"drug\": \"cisplatin\"}]", "role": "assistant" } ]

Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.

[ { "ade": "severe persistent bronchospasm", "drug": "tobramycin" }, { "ade": "recurrent eosinophilia", "drug": "tobramycin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Inhaled tobramycin solution-associated recurrent eosinophilia and severe persistent bronchospasm in a patient with cystic fibrosis: a case report.", "role": "user" }, { "content": "[{\"ade\": \"severe persistent bronchospasm\", \"drug\": \"tobramycin\"}, {\"ade\": \"recurrent eosinophilia\", \"drug\": \"tobramycin\"}]", "role": "assistant" } ]

Ischaemic colitis in a patient taking meloxicam.

[ { "ade": "Ischaemic colitis", "drug": "meloxicam" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Ischaemic colitis in a patient taking meloxicam.", "role": "user" }, { "content": "[{\"ade\": \"Ischaemic colitis\", \"drug\": \"meloxicam\"}]", "role": "assistant" } ]

METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.

[ { "ade": "vomiting", "drug": "Viokase" }, { "ade": "vomiting", "drug": "Pancrease MT 16" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.", "role": "user" }, { "content": "[{\"ade\": \"vomiting\", \"drug\": \"Viokase\"}, {\"ade\": \"vomiting\", \"drug\": \"Pancrease MT 16\"}]", "role": "assistant" } ]

We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.

[ { "ade": "anaphylaxis", "drug": "metaraminol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol.", "role": "user" }, { "content": "[{\"ade\": \"anaphylaxis\", \"drug\": \"metaraminol\"}]", "role": "assistant" } ]

Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.

[ { "ade": "visual field defects", "drug": "Vigabatrin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Vigabatrin-induced visual field defects are at present the most important safety issue in the use of the drug.", "role": "user" }, { "content": "[{\"ade\": \"visual field defects\", \"drug\": \"Vigabatrin\"}]", "role": "assistant" } ]

Temozolomide was restarted 2 months later; the patient again developed a fever.

[ { "ade": "fever", "drug": "Temozolomide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Temozolomide was restarted 2 months later; the patient again developed a fever.", "role": "user" }, { "content": "[{\"ade\": \"fever\", \"drug\": \"Temozolomide\"}]", "role": "assistant" } ]

Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.

[ { "ade": "Sustained ventricular tachycardia", "drug": "thalidomide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sustained ventricular tachycardia in a thalidomide-treated patient with primary plasma-cell leukemia.", "role": "user" }, { "content": "[{\"ade\": \"Sustained ventricular tachycardia\", \"drug\": \"thalidomide\"}]", "role": "assistant" } ]

Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.

[ { "ade": "pulmonary infiltrate", "drug": "Rapamycin" }, { "ade": "pulmonary infiltrate", "drug": "SR" }, { "ade": "pulmonary infiltrate", "drug": "sirolimus" }, { "ade": "pneumonitis", "drug": "Rapamycin" }, { "ade": "pneumonitis", "drug": "sirolimus" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Rapamycin/sirolimus-induced pneumonitis has been described previously in renal transplant recipients, and this report describes a stable heart-lung transplant recipient who developed a pulmonary infiltrate that reversed after ceasing SR therapy.", "role": "user" }, { "content": "[{\"ade\": \"pulmonary infiltrate\", \"drug\": \"Rapamycin\"}, {\"ade\": \"pulmonary infiltrate\", \"drug\": \"SR\"}, {\"ade\": \"pulmonary infiltrate\", \"drug\": \"sirolimus\"}, {\"ade\": \"pneumonitis\", \"drug\": \"Rapamycin\"}, {\"ade\": \"pneumonitis\", \"drug\": \"sirolimus\"}]", "role": "assistant" } ]

The mean time from starting MMF to the development of neutropenia was 4 months.

[ { "ade": "neutropenia", "drug": "MMF" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The mean time from starting MMF to the development of neutropenia was 4 months.", "role": "user" }, { "content": "[{\"ade\": \"neutropenia\", \"drug\": \"MMF\"}]", "role": "assistant" } ]

Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.

[ { "ade": "thyrotoxicosis", "drug": "amiodarone" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or radioactive iodine is ineffective.", "role": "user" }, { "content": "[{\"ade\": \"thyrotoxicosis\", \"drug\": \"amiodarone\"}]", "role": "assistant" } ]

OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.

[ { "ade": "reproductive endocrine disorders", "drug": "valproate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: OBJECTIVE: To describe the development of valproate-related reproductive endocrine disorders in women with epilepsy.", "role": "user" }, { "content": "[{\"ade\": \"reproductive endocrine disorders\", \"drug\": \"valproate\"}]", "role": "assistant" } ]

Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.

[ { "ade": "granulomas", "drug": "methotrexate" }, { "ade": "pneumonitis", "drug": "methotrexate" }, { "ade": "Pulmonary eosinophilia", "drug": "methotrexate" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Pulmonary eosinophilia or granulomas, classically seen in previously reported cases of methotrexate pneumonitis, were not observed.", "role": "user" }, { "content": "[{\"ade\": \"granulomas\", \"drug\": \"methotrexate\"}, {\"ade\": \"pneumonitis\", \"drug\": \"methotrexate\"}, {\"ade\": \"Pulmonary eosinophilia\", \"drug\": \"methotrexate\"}]", "role": "assistant" } ]

Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.

[ { "ade": "Hypertension", "drug": "prednisone" }, { "ade": "Hypertension", "drug": "cyclosporine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hypertension develops in most patients after transplantation when immunosuppression is based on cyclosporine and prednisone.", "role": "user" }, { "content": "[{\"ade\": \"Hypertension\", \"drug\": \"prednisone\"}, {\"ade\": \"Hypertension\", \"drug\": \"cyclosporine\"}]", "role": "assistant" } ]

Gemcitabine-induced rectus abdominus radiation recall.

[ { "ade": "rectus abdominus radiation recall", "drug": "Gemcitabine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Gemcitabine-induced rectus abdominus radiation recall.", "role": "user" }, { "content": "[{\"ade\": \"rectus abdominus radiation recall\", \"drug\": \"Gemcitabine\"}]", "role": "assistant" } ]

CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.

[ { "ade": "hypercalcemia", "drug": "vitamin D" }, { "ade": "acute vitamin D poisoning", "drug": "vitamin D" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: We report a case of the use of pamidronate for significant hypercalcemia secondary to acute vitamin D poisoning.", "role": "user" }, { "content": "[{\"ade\": \"hypercalcemia\", \"drug\": \"vitamin D\"}, {\"ade\": \"acute vitamin D poisoning\", \"drug\": \"vitamin D\"}]", "role": "assistant" } ]

We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.

[ { "ade": "WES", "drug": "haloperidol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.", "role": "user" }, { "content": "[{\"ade\": \"WES\", \"drug\": \"haloperidol\"}]", "role": "assistant" } ]

DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.

[ { "ade": "SS", "drug": "mirtazapine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: DISCUSSION: A review of the cases of SS with implication of mirtazapine as the cause was performed.", "role": "user" }, { "content": "[{\"ade\": \"SS\", \"drug\": \"mirtazapine\"}]", "role": "assistant" } ]

She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.

[ { "ade": "dysarthria", "drug": "metoclopramide" }, { "ade": "movement disorder", "drug": "metoclopramide" }, { "ade": "agitation", "drug": "metoclopramide" }, { "ade": "diaphoresis", "drug": "metoclopramide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.", "role": "user" }, { "content": "[{\"ade\": \"dysarthria\", \"drug\": \"metoclopramide\"}, {\"ade\": \"movement disorder\", \"drug\": \"metoclopramide\"}, {\"ade\": \"agitation\", \"drug\": \"metoclopramide\"}, {\"ade\": \"diaphoresis\", \"drug\": \"metoclopramide\"}]", "role": "assistant" } ]

Allopurinol hypersensitivity.

[ { "ade": "hypersensitivity", "drug": "Allopurinol" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Allopurinol hypersensitivity.", "role": "user" }, { "content": "[{\"ade\": \"hypersensitivity\", \"drug\": \"Allopurinol\"}]", "role": "assistant" } ]

Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.

[ { "ade": "toxic epidermal necrolysis", "drug": "Levofloxacin" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Levofloxacin-induced toxic epidermal necrolysis in an elderly patient.", "role": "user" }, { "content": "[{\"ade\": \"toxic epidermal necrolysis\", \"drug\": \"Levofloxacin\"}]", "role": "assistant" } ]

In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.

[ { "ade": "RSDS", "drug": "tacrolimus" }, { "ade": "RSDS", "drug": "CyA" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In conclusion, RSDS is a relevant osteoarticular complication in patients receiving either anticalcineurinic drug (CyA or tacrolimus), even under monotherapy or with a low steroid dose.", "role": "user" }, { "content": "[{\"ade\": \"RSDS\", \"drug\": \"tacrolimus\"}, {\"ade\": \"RSDS\", \"drug\": \"CyA\"}]", "role": "assistant" } ]

Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.

[ { "ade": "thyrotropin receptor antibody", "drug": "Amiodarone" }, { "ade": "thyrotoxicosis", "drug": "Amiodarone" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Amiodarone-induced thyrotoxicosis associated with thyrotropin receptor antibody.", "role": "user" }, { "content": "[{\"ade\": \"thyrotropin receptor antibody\", \"drug\": \"Amiodarone\"}, {\"ade\": \"thyrotoxicosis\", \"drug\": \"Amiodarone\"}]", "role": "assistant" } ]

The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.

[ { "ade": "migraine headaches", "drug": "methysergide" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The patient whose case is reviewed had migraine headaches and received methysergide maleate for 13 years.", "role": "user" }, { "content": "[{\"ade\": \"migraine headaches\", \"drug\": \"methysergide\"}]", "role": "assistant" } ]

Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.

[ { "ade": "thyroiditis", "drug": "amiodarone" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Failure of plasmapheresis, corticosteroids and thionamides to ameliorate a case of protracted amiodarone-induced thyroiditis.", "role": "user" }, { "content": "[{\"ade\": \"thyroiditis\", \"drug\": \"amiodarone\"}]", "role": "assistant" } ]

Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.

[ { "ade": "arteriospasm", "drug": "ergotamine" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Reversal of ergotamine-induced arteriospasm by mechanical intra-arterial dilatation.", "role": "user" }, { "content": "[{\"ade\": \"arteriospasm\", \"drug\": \"ergotamine\"}]", "role": "assistant" } ]

The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.

[ { "ade": "accelerate HIV disease", "drug": "methotrexate" }, { "ade": "accelerate HIV disease", "drug": "MTX" } ]

[ { "content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.", "role": "user" }, { "content": "[{\"ade\": \"accelerate HIV disease\", \"drug\": \"methotrexate\"}, {\"ade\": \"accelerate HIV disease\", \"drug\": \"MTX\"}]", "role": "assistant" } ]