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A 53-year-old man developed NMS without rigidity while taking olanzapine.
|
[
{
"ade": "NMS",
"drug": "olanzapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 53-year-old man developed NMS without rigidity while taking olanzapine.",
"role": "user"
},
{
"content": "[{\"ade\": \"NMS\", \"drug\": \"olanzapine\"}]",
"role": "assistant"
}
] |
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.
|
[
{
"ade": "delay corneal wound healing",
"drug": "colchicine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.",
"role": "user"
},
{
"content": "[{\"ade\": \"delay corneal wound healing\", \"drug\": \"colchicine\"}]",
"role": "assistant"
}
] |
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.
|
[
{
"ade": "ocular toxicity",
"drug": "ethambutol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe.",
"role": "user"
},
{
"content": "[{\"ade\": \"ocular toxicity\", \"drug\": \"ethambutol\"}]",
"role": "assistant"
}
] |
Drug-induced fever due to diltiazem.
|
[
{
"ade": "fever",
"drug": "diltiazem"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Drug-induced fever due to diltiazem.",
"role": "user"
},
{
"content": "[{\"ade\": \"fever\", \"drug\": \"diltiazem\"}]",
"role": "assistant"
}
] |
Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.
|
[
{
"ade": "Neutrophilic eccrine hidradenitis",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide.",
"role": "user"
},
{
"content": "[{\"ade\": \"Neutrophilic eccrine hidradenitis\", \"drug\": \"cyclophosphamide\"}]",
"role": "assistant"
}
] |
Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.
|
[
{
"ade": "Acute generalized exanthematous pustulosis",
"drug": "morphine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute generalized exanthematous pustulosis caused by morphine, confirmed by positive patch test and lymphocyte transformation test.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute generalized exanthematous pustulosis\", \"drug\": \"morphine\"}]",
"role": "assistant"
}
] |
Anhedonic ejaculation with desipramine.
|
[
{
"ade": "Anhedonic ejaculation",
"drug": "desipramine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Anhedonic ejaculation with desipramine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Anhedonic ejaculation\", \"drug\": \"desipramine\"}]",
"role": "assistant"
}
] |
Severe vancomycin-induced anaphylactic reaction.
|
[
{
"ade": "anaphylactic reaction",
"drug": "vancomycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Severe vancomycin-induced anaphylactic reaction.",
"role": "user"
},
{
"content": "[{\"ade\": \"anaphylactic reaction\", \"drug\": \"vancomycin\"}]",
"role": "assistant"
}
] |
Phenobarbital hepatotoxicity in an 8-month-old infant.
|
[
{
"ade": "hepatotoxicity",
"drug": "Phenobarbital"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Phenobarbital hepatotoxicity in an 8-month-old infant.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatotoxicity\", \"drug\": \"Phenobarbital\"}]",
"role": "assistant"
}
] |
Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.
|
[
{
"ade": "Withdrawal emergent syndrome",
"drug": "haloperidol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Withdrawal emergent syndrome\", \"drug\": \"haloperidol\"}]",
"role": "assistant"
}
] |
Gold-induced pneumonitis.
|
[
{
"ade": "pneumonitis",
"drug": "Gold"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Gold-induced pneumonitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"pneumonitis\", \"drug\": \"Gold\"}]",
"role": "assistant"
}
] |
The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).
|
[
{
"ade": "neurotoxicity",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The syndrome of irreversible lithium-effectuated neurotoxicity (SILENT).",
"role": "user"
},
{
"content": "[{\"ade\": \"neurotoxicity\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.
|
[
{
"ade": "ototoxicity",
"drug": "ketorolac"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.",
"role": "user"
},
{
"content": "[{\"ade\": \"ototoxicity\", \"drug\": \"ketorolac\"}]",
"role": "assistant"
}
] |
Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.
|
[
{
"ade": "Schneiderian first-rank symptoms",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report.",
"role": "user"
},
{
"content": "[{\"ade\": \"Schneiderian first-rank symptoms\", \"drug\": \"fluvoxamine\"}]",
"role": "assistant"
}
] |
This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.
|
[
{
"ade": "Schneiderian first-rank symptoms",
"drug": "fluvoxamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This communication describes a patient who developed Schneiderian first-rank symptoms in the course of treatment with fluvoxamine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Schneiderian first-rank symptoms\", \"drug\": \"fluvoxamine\"}]",
"role": "assistant"
}
] |
Dasatinib-induced pleural effusions: a lymphatic network disorder?
|
[
{
"ade": "pleural effusions",
"drug": "Dasatinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Dasatinib-induced pleural effusions: a lymphatic network disorder?",
"role": "user"
},
{
"content": "[{\"ade\": \"pleural effusions\", \"drug\": \"Dasatinib\"}]",
"role": "assistant"
}
] |
Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.
|
[
{
"ade": "ARF",
"drug": "mannitol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hemodialysis should be performed for rapid reversal of mannitol-induced ARF.",
"role": "user"
},
{
"content": "[{\"ade\": \"ARF\", \"drug\": \"mannitol\"}]",
"role": "assistant"
}
] |
CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.
|
[
{
"ade": "anaphylactoid reactions",
"drug": "cisplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CASE SUMMARIES: While conducting a protocol evaluating the efficacy of intraperitoneal cisplatin and hyperthermia in the treatment of recurrent ovarian cancer, 3 patients were noted to exhibit anaphylactoid reactions.",
"role": "user"
},
{
"content": "[{\"ade\": \"anaphylactoid reactions\", \"drug\": \"cisplatin\"}]",
"role": "assistant"
}
] |
Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.
|
[
{
"ade": "transient thyrotoxicosis",
"drug": "Lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.",
"role": "user"
},
{
"content": "[{\"ade\": \"transient thyrotoxicosis\", \"drug\": \"Lithium\"}]",
"role": "assistant"
}
] |
In one case, disulfiram was the only potential teratogen exposed to the fetus.
|
[
{
"ade": "teratogen",
"drug": "disulfiram"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In one case, disulfiram was the only potential teratogen exposed to the fetus.",
"role": "user"
},
{
"content": "[{\"ade\": \"teratogen\", \"drug\": \"disulfiram\"}]",
"role": "assistant"
}
] |
Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.
|
[
{
"ade": "protamine hypersensitivity",
"drug": "neutral protamine Hagedorn (NPH) insulin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Patients receiving neutral protamine Hagedorn (NPH) insulin are at increased risk for the development of protamine hypersensitivity.",
"role": "user"
},
{
"content": "[{\"ade\": \"protamine hypersensitivity\", \"drug\": \"neutral protamine Hagedorn (NPH) insulin\"}]",
"role": "assistant"
}
] |
Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.
|
[
{
"ade": "oesophageal damage",
"drug": "emepronium bromide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.",
"role": "user"
},
{
"content": "[{\"ade\": \"oesophageal damage\", \"drug\": \"emepronium bromide\"}]",
"role": "assistant"
}
] |
We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).
|
[
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "vindesine"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "CDDP"
},
{
"ade": "SIADH",
"drug": "CDDP"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "vindesine"
},
{
"ade": "SIADH",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "VDS"
},
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "VDS"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).",
"role": "user"
},
{
"content": "[{\"ade\": \"syndrome of inappropriate secretion of antidiuretic hormone\", \"drug\": \"cisplatin\"}, {\"ade\": \"SIADH\", \"drug\": \"vindesine\"}, {\"ade\": \"syndrome of inappropriate secretion of antidiuretic hormone\", \"drug\": \"CDDP\"}, {\"ade\": \"SIADH\", \"drug\": \"CDDP\"}, {\"ade\": \"syndrome of inappropriate secretion of antidiuretic hormone\", \"drug\": \"vindesine\"}, {\"ade\": \"SIADH\", \"drug\": \"cisplatin\"}, {\"ade\": \"SIADH\", \"drug\": \"VDS\"}, {\"ade\": \"syndrome of inappropriate secretion of antidiuretic hormone\", \"drug\": \"VDS\"}]",
"role": "assistant"
}
] |
Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.
|
[
{
"ade": "carcinoma of the corpus uteri",
"drug": "tamoxifen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Data have been published regarding the possibility that tamoxifen may be responsible for the subsequent development of carcinoma of the corpus uteri in these patients.",
"role": "user"
},
{
"content": "[{\"ade\": \"carcinoma of the corpus uteri\", \"drug\": \"tamoxifen\"}]",
"role": "assistant"
}
] |
CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.
|
[
{
"ade": "malignant transformation of endometriosis",
"drug": "Tamoxifen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state.",
"role": "user"
},
{
"content": "[{\"ade\": \"malignant transformation of endometriosis\", \"drug\": \"Tamoxifen\"}]",
"role": "assistant"
}
] |
Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.
|
[
{
"ade": "severe neutropenia",
"drug": "olanzapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Thus any case of severe neutropenia occurring in a patient receiving olanzapine is alarming to clinicians.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe neutropenia\", \"drug\": \"olanzapine\"}]",
"role": "assistant"
}
] |
Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.
|
[
{
"ade": "hypoglycemia",
"drug": "insulin"
},
{
"ade": "hypoglycemia",
"drug": "etanercept"
},
{
"ade": "Hypoglycemia",
"drug": "etanercept"
},
{
"ade": "hypoglycemia",
"drug": "meglitinides"
},
{
"ade": "hypoglycemia",
"drug": "sulfonylureas"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypoglycemia\", \"drug\": \"insulin\"}, {\"ade\": \"hypoglycemia\", \"drug\": \"etanercept\"}, {\"ade\": \"Hypoglycemia\", \"drug\": \"etanercept\"}, {\"ade\": \"hypoglycemia\", \"drug\": \"meglitinides\"}, {\"ade\": \"hypoglycemia\", \"drug\": \"sulfonylureas\"}]",
"role": "assistant"
}
] |
This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.
|
[
{
"ade": "hepatocellular carcinoma",
"drug": "diethylstilbestrol"
},
{
"ade": "hepatocellular carcinoma",
"drug": "DES"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This is a unique autopsy case of hepatocellular carcinoma closely related to diethylstilbestrol (DES) therapy for prostatic cancer.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatocellular carcinoma\", \"drug\": \"diethylstilbestrol\"}, {\"ade\": \"hepatocellular carcinoma\", \"drug\": \"DES\"}]",
"role": "assistant"
}
] |
CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.
|
[
{
"ade": "intracerebral hemorrhage",
"drug": "pseudoephedrine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CASE REPORT: We report a case of intracerebral hemorrhage occurring in a middle-aged man who suffered from chronic sinusitis and had been ingesting pseudoephedrine daily for one year.",
"role": "user"
},
{
"content": "[{\"ade\": \"intracerebral hemorrhage\", \"drug\": \"pseudoephedrine\"}]",
"role": "assistant"
}
] |
Magnesium tocolysis as the cause of urinary calculus during pregnancy.
|
[
{
"ade": "urinary calculus",
"drug": "Magnesium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Magnesium tocolysis as the cause of urinary calculus during pregnancy.",
"role": "user"
},
{
"content": "[{\"ade\": \"urinary calculus\", \"drug\": \"Magnesium\"}]",
"role": "assistant"
}
] |
Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.
|
[
{
"ade": "tardive dyskinesia",
"drug": "Clozapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Clozapine-induced tardive dyskinesia in schizophrenic patients taking clozapine as a first-line antipsychotic drug.",
"role": "user"
},
{
"content": "[{\"ade\": \"tardive dyskinesia\", \"drug\": \"Clozapine\"}]",
"role": "assistant"
}
] |
Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.
|
[
{
"ade": "swelling of the face and legs",
"drug": "phenytoin"
},
{
"ade": "pruritus",
"drug": "phenytoin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Phenytoin was discontinued after admission; however, phenytoin 1 g i.v. was given for a tonic-clonic seizure two days after admission, after which swelling of the face and legs and pruritus developed.",
"role": "user"
},
{
"content": "[{\"ade\": \"swelling of the face and legs\", \"drug\": \"phenytoin\"}, {\"ade\": \"pruritus\", \"drug\": \"phenytoin\"}]",
"role": "assistant"
}
] |
Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.
|
[
{
"ade": "renal tubular dysfunction",
"drug": "sulfamethoxazole-trimethoprim"
},
{
"ade": "Hyperkalaemia",
"drug": "sulfamethoxazole-trimethoprim"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hyperkalaemia with renal tubular dysfunction by sulfamethoxazole-trimethoprim for Pneumocystis carinii pneumonia in patients with lymphoid malignancy.",
"role": "user"
},
{
"content": "[{\"ade\": \"renal tubular dysfunction\", \"drug\": \"sulfamethoxazole-trimethoprim\"}, {\"ade\": \"Hyperkalaemia\", \"drug\": \"sulfamethoxazole-trimethoprim\"}]",
"role": "assistant"
}
] |
Cataracts induced by intermittent Decadron used as an antiemetic.
|
[
{
"ade": "Cataracts",
"drug": "Decadron"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cataracts induced by intermittent Decadron used as an antiemetic.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cataracts\", \"drug\": \"Decadron\"}]",
"role": "assistant"
}
] |
Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.
|
[
{
"ade": "Hepatotoxicity",
"drug": "choline magnesium trisalicylate"
},
{
"ade": "hepatotoxicity",
"drug": "salicylate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hepatotoxicity associated with choline magnesium trisalicylate: case report and review of salicylate-induced hepatotoxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"Hepatotoxicity\", \"drug\": \"choline magnesium trisalicylate\"}, {\"ade\": \"hepatotoxicity\", \"drug\": \"salicylate\"}]",
"role": "assistant"
}
] |
It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.
|
[
{
"ade": "fulminant hepatic failure",
"drug": "nicotinic acid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"fulminant hepatic failure\", \"drug\": \"nicotinic acid\"}]",
"role": "assistant"
}
] |
We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.
|
[
{
"ade": "persistent hypoglycemia",
"drug": "etanercept"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a patient with type 2 diabetes mellitus who, while treated with the antitumor necrosis factor-alpha blocking agent etanercept for severe plaque psoriasis, experienced persistent hypoglycemia requiring the lowering and eventual elimination of his previous insulin regimen.",
"role": "user"
},
{
"content": "[{\"ade\": \"persistent hypoglycemia\", \"drug\": \"etanercept\"}]",
"role": "assistant"
}
] |
Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.
|
[
{
"ade": "neutropenia",
"drug": "penicillin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Typically, drug-induced neutropenia occurs in a patient receiving a semisynthetic penicillin for two weeks or more.",
"role": "user"
},
{
"content": "[{\"ade\": \"neutropenia\", \"drug\": \"penicillin\"}]",
"role": "assistant"
}
] |
Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.
|
[
{
"ade": "Meibomian duct inflammation and blockage",
"drug": "Docetaxel"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Docetaxel induced Meibomian duct inflammation and blockage is the likely cause of this presentation in a patient with no history of eyelid masses in the past.",
"role": "user"
},
{
"content": "[{\"ade\": \"Meibomian duct inflammation and blockage\", \"drug\": \"Docetaxel\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.
|
[
{
"ade": "asthma attack",
"drug": "verapamil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: Sustained-release verapamil is thought to be the cause of the asthma attack in this patient because she was not taking any other preparations; the symptoms started with the administration of sustained-release verapamil and were relieved after its discontinuation.",
"role": "user"
},
{
"content": "[{\"ade\": \"asthma attack\", \"drug\": \"verapamil\"}]",
"role": "assistant"
}
] |
Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.
|
[
{
"ade": "neurotoxicity",
"drug": "CAP"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"neurotoxicity\", \"drug\": \"CAP\"}]",
"role": "assistant"
}
] |
Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.
|
[
{
"ade": "autoimmune hepatitis",
"drug": "Minocycline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Minocycline-induced autoimmune hepatitis is usually identical to sporadic autoimmune hepatitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"autoimmune hepatitis\", \"drug\": \"Minocycline\"}]",
"role": "assistant"
}
] |
We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.
|
[
{
"ade": "infectious toxicities",
"drug": "dexamethasone"
},
{
"ade": "infectious complications",
"drug": "dexamethasone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe the infectious toxicities experienced by the first two patients in our institution treated with dexamethasone (10 mg/m(2)/day for 4 weeks with gradual tapering) during induction according to the dexamethasone arm of BFM 2000 and review the relevant literature that suggests an increased risk of infectious complications with dexamethasone.",
"role": "user"
},
{
"content": "[{\"ade\": \"infectious toxicities\", \"drug\": \"dexamethasone\"}, {\"ade\": \"infectious complications\", \"drug\": \"dexamethasone\"}]",
"role": "assistant"
}
] |
The following is a report of 2 cases of rifampicin-induced renal insufficiency.
|
[
{
"ade": "renal insufficiency",
"drug": "rifampicin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The following is a report of 2 cases of rifampicin-induced renal insufficiency.",
"role": "user"
},
{
"content": "[{\"ade\": \"renal insufficiency\", \"drug\": \"rifampicin\"}]",
"role": "assistant"
}
] |
Inappropriate antidiuretic hormone secretion after high dose vinblastine.
|
[
{
"ade": "Inappropriate antidiuretic hormone secretion",
"drug": "vinblastine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Inappropriate antidiuretic hormone secretion after high dose vinblastine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Inappropriate antidiuretic hormone secretion\", \"drug\": \"vinblastine\"}]",
"role": "assistant"
}
] |
Alprazolam-induced mania: two clinical cases.
|
[
{
"ade": "mania",
"drug": "Alprazolam"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Alprazolam-induced mania: two clinical cases.",
"role": "user"
},
{
"content": "[{\"ade\": \"mania\", \"drug\": \"Alprazolam\"}]",
"role": "assistant"
}
] |
Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.
|
[
{
"ade": "Interstitial fibrosis of the lung",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Interstitial fibrosis of the lung\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
Bisphosphonate-related osteonecrosis of the skull base.
|
[
{
"ade": "osteonecrosis of the skull base",
"drug": "Bisphosphonate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Bisphosphonate-related osteonecrosis of the skull base.",
"role": "user"
},
{
"content": "[{\"ade\": \"osteonecrosis of the skull base\", \"drug\": \"Bisphosphonate\"}]",
"role": "assistant"
}
] |
In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.
|
[
{
"ade": "interstitial pneumopathy",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In a 61-year-old man receiving chronic low-dosage amiodarone an interstitial pneumopathy was observed.",
"role": "user"
},
{
"content": "[{\"ade\": \"interstitial pneumopathy\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.
|
[
{
"ade": "hepatic VOD",
"drug": "tacrolimus"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: One case of tacrolimus-induced hepatic VOD developing after lung transplantation (LT) has been recently reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatic VOD\", \"drug\": \"tacrolimus\"}]",
"role": "assistant"
}
] |
Colchicine-induced myopathy in a teenager with familial Mediterranean fever.
|
[
{
"ade": "myopathy",
"drug": "Colchicine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Colchicine-induced myopathy in a teenager with familial Mediterranean fever.",
"role": "user"
},
{
"content": "[{\"ade\": \"myopathy\", \"drug\": \"Colchicine\"}]",
"role": "assistant"
}
] |
Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.
|
[
{
"ade": "dementia",
"drug": "valproic acid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies.",
"role": "user"
},
{
"content": "[{\"ade\": \"dementia\", \"drug\": \"valproic acid\"}]",
"role": "assistant"
}
] |
We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.
|
[
{
"ade": "human teratogen",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We conclude that (a) cyclophosphamide is a human teratogen, (b) a distinct phenotype exists, and (c) the safety of CP in pregnancy is in serious question.",
"role": "user"
},
{
"content": "[{\"ade\": \"human teratogen\", \"drug\": \"cyclophosphamide\"}]",
"role": "assistant"
}
] |
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.
|
[
{
"ade": "Nephrogenic diabetes insipidus",
"drug": "lithium"
},
{
"ade": "NDI",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.",
"role": "user"
},
{
"content": "[{\"ade\": \"Nephrogenic diabetes insipidus\", \"drug\": \"lithium\"}, {\"ade\": \"NDI\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.
|
[
{
"ade": "Sirolimus-eluting stent thrombosis",
"drug": "clopidogrel"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sirolimus-eluting stent thrombosis several years after clopidogrel discontinuation.",
"role": "user"
},
{
"content": "[{\"ade\": \"Sirolimus-eluting stent thrombosis\", \"drug\": \"clopidogrel\"}]",
"role": "assistant"
}
] |
OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.
|
[
{
"ade": "splenomegaly",
"drug": "adalimumab"
},
{
"ade": "fever",
"drug": "adalimumab"
},
{
"ade": "pancytopenia",
"drug": "adalimumab"
},
{
"ade": "extreme hyperferritinemia",
"drug": "adalimumab"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: OBJECTIVE: 1) To describe a patient with rheumatoid arthritis receiving adalimumab who developed fever, pancytopenia, splenomegaly, and extreme hyperferritinemia.",
"role": "user"
},
{
"content": "[{\"ade\": \"splenomegaly\", \"drug\": \"adalimumab\"}, {\"ade\": \"fever\", \"drug\": \"adalimumab\"}, {\"ade\": \"pancytopenia\", \"drug\": \"adalimumab\"}, {\"ade\": \"extreme hyperferritinemia\", \"drug\": \"adalimumab\"}]",
"role": "assistant"
}
] |
Cholestyramine induced hyperchloremic metabolic acidosis.
|
[
{
"ade": "hyperchloremic metabolic acidosis",
"drug": "Cholestyramine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cholestyramine induced hyperchloremic metabolic acidosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyperchloremic metabolic acidosis\", \"drug\": \"Cholestyramine\"}]",
"role": "assistant"
}
] |
The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.
|
[
{
"ade": "collagenous colitis",
"drug": "lansoprazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"collagenous colitis\", \"drug\": \"lansoprazole\"}]",
"role": "assistant"
}
] |
Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.
|
[
{
"ade": "Insulin-dependent diabetes mellitus",
"drug": "danazol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Insulin-dependent diabetes mellitus developed in a young woman 8 weeks after the initiation of danazol for treatment of pelvic endometriosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Insulin-dependent diabetes mellitus\", \"drug\": \"danazol\"}]",
"role": "assistant"
}
] |
Taxane-induced glaucoma.
|
[
{
"ade": "glaucoma",
"drug": "Taxane"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Taxane-induced glaucoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"glaucoma\", \"drug\": \"Taxane\"}]",
"role": "assistant"
}
] |
During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.
|
[
{
"ade": "torsade de pointes",
"drug": "terlipressin"
},
{
"ade": "prolonged QT interval",
"drug": "terlipressin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes.",
"role": "user"
},
{
"content": "[{\"ade\": \"torsade de pointes\", \"drug\": \"terlipressin\"}, {\"ade\": \"prolonged QT interval\", \"drug\": \"terlipressin\"}]",
"role": "assistant"
}
] |
One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.
|
[
{
"ade": "SMON",
"drug": "clioquinol"
},
{
"ade": "acrodermatitis enteropathica",
"drug": "clioquinol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: One type of SMON is associated with acrodermatitis enteropathica which has a very high frequency of occurrence in association with administration of clioquinol.",
"role": "user"
},
{
"content": "[{\"ade\": \"SMON\", \"drug\": \"clioquinol\"}, {\"ade\": \"acrodermatitis enteropathica\", \"drug\": \"clioquinol\"}]",
"role": "assistant"
}
] |
A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.
|
[
{
"ade": "tonic-clonic seizures",
"drug": "clozapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A case of clozapine-induced tonic-clonic seizures managed with valproate: implications for clinical care.",
"role": "user"
},
{
"content": "[{\"ade\": \"tonic-clonic seizures\", \"drug\": \"clozapine\"}]",
"role": "assistant"
}
] |
A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.
|
[
{
"ade": "hemolytic and/or thrombocytopenic reactions",
"drug": "oxaliplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A small number of oxaliplatin-related hemolytic and/or thrombocytopenic reactions have been reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"hemolytic and/or thrombocytopenic reactions\", \"drug\": \"oxaliplatin\"}]",
"role": "assistant"
}
] |
L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.
|
[
{
"ade": "pancreatitis",
"drug": "L-asparaginase"
},
{
"ade": "lethal complication",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.",
"role": "user"
},
{
"content": "[{\"ade\": \"pancreatitis\", \"drug\": \"L-asparaginase\"}, {\"ade\": \"lethal complication\", \"drug\": \"L-asparaginase\"}]",
"role": "assistant"
}
] |
Sirolimus-associated hepatotoxicity in the kidney graft recipient.
|
[
{
"ade": "hepatotoxicity",
"drug": "Sirolimus"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sirolimus-associated hepatotoxicity in the kidney graft recipient.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatotoxicity\", \"drug\": \"Sirolimus\"}]",
"role": "assistant"
}
] |
The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.
|
[
{
"ade": "granulocytopenia",
"drug": "procainamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The frequency and relationship of granulocytopenia caused by sustained-release procainamide in patients with tachyarrhythmias are briefly discussed, and prior reported cases are reviewed.",
"role": "user"
},
{
"content": "[{\"ade\": \"granulocytopenia\", \"drug\": \"procainamide\"}]",
"role": "assistant"
}
] |
Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.
|
[
{
"ade": "Acute vision loss",
"drug": "bevacizumab"
},
{
"ade": "ocular ischemic syndrome",
"drug": "bevacizumab"
},
{
"ade": "ocular ischemic syndrome",
"drug": "avastin"
},
{
"ade": "Acute vision loss",
"drug": "avastin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute vision loss after intravitreal injection of bevacizumab (avastin) associated with ocular ischemic syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute vision loss\", \"drug\": \"bevacizumab\"}, {\"ade\": \"ocular ischemic syndrome\", \"drug\": \"bevacizumab\"}, {\"ade\": \"ocular ischemic syndrome\", \"drug\": \"avastin\"}, {\"ade\": \"Acute vision loss\", \"drug\": \"avastin\"}]",
"role": "assistant"
}
] |
Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.
|
[
{
"ade": "pseudomembranous colitis",
"drug": "clindamycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Five cases of clindamycin-associated pseudomembranous colitis in leukaemic patients are reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"pseudomembranous colitis\", \"drug\": \"clindamycin\"}]",
"role": "assistant"
}
] |
Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.
|
[
{
"ade": "Syndrome of inappropriate secretion of ADH",
"drug": "cisplatin"
},
{
"ade": "SIADH",
"drug": "cisplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.",
"role": "user"
},
{
"content": "[{\"ade\": \"Syndrome of inappropriate secretion of ADH\", \"drug\": \"cisplatin\"}, {\"ade\": \"SIADH\", \"drug\": \"cisplatin\"}]",
"role": "assistant"
}
] |
Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.
|
[
{
"ade": "acute leukemia",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Prolonged used of hydroxyurea in patients with ET may lead to therapy-associated acute leukemia.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute leukemia\", \"drug\": \"hydroxyurea\"}]",
"role": "assistant"
}
] |
In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.
|
[
{
"ade": "blast crisis",
"drug": "imatinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"blast crisis\", \"drug\": \"imatinib\"}]",
"role": "assistant"
}
] |
Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).
|
[
{
"ade": "reaction to the drug became more toxic",
"drug": "theophylline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Attempts were made to stop and then restart the theophylline therapy at progressively lower doses; however, with each attempt, the patient's reaction to the drug became more toxic, with serum theophylline levels ranging between 99.9 and 149.9 micromol/L (18 and 27 microg/mL).",
"role": "user"
},
{
"content": "[{\"ade\": \"reaction to the drug became more toxic\", \"drug\": \"theophylline\"}]",
"role": "assistant"
}
] |
Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.
|
[
{
"ade": "psoriasiform eruptions",
"drug": "carbamazepine"
},
{
"ade": "psoriasiform eruptions",
"drug": "Sodium valproate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions.",
"role": "user"
},
{
"content": "[{\"ade\": \"psoriasiform eruptions\", \"drug\": \"carbamazepine\"}, {\"ade\": \"psoriasiform eruptions\", \"drug\": \"Sodium valproate\"}]",
"role": "assistant"
}
] |
A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.
|
[
{
"ade": "oesophageal varices",
"drug": "busulphan"
},
{
"ade": "jaundice",
"drug": "busulphan"
},
{
"ade": "ascites",
"drug": "busulphan"
},
{
"ade": "portal hypertension",
"drug": "busulphan"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A patient with chronic myeloid leukaemia treated with busulphan for 4-5 years, developed signs of busulphan toxicity and portal hypertension with ascites, oesophageal varices and jaundice.",
"role": "user"
},
{
"content": "[{\"ade\": \"oesophageal varices\", \"drug\": \"busulphan\"}, {\"ade\": \"jaundice\", \"drug\": \"busulphan\"}, {\"ade\": \"ascites\", \"drug\": \"busulphan\"}, {\"ade\": \"portal hypertension\", \"drug\": \"busulphan\"}]",
"role": "assistant"
}
] |
He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.
|
[
{
"ade": "hypersensitivity reaction",
"drug": "MTX"
},
{
"ade": "chest tightness",
"drug": "MTX"
},
{
"ade": "diffuse urticaria",
"drug": "MTX"
},
{
"ade": "facial swelling",
"drug": "MTX"
},
{
"ade": "cough",
"drug": "MTX"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: He had an immediate hypersensitivity reaction during the initiation of the MTX infusion with diffuse urticaria, facial swelling, cough, and chest tightness.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypersensitivity reaction\", \"drug\": \"MTX\"}, {\"ade\": \"chest tightness\", \"drug\": \"MTX\"}, {\"ade\": \"diffuse urticaria\", \"drug\": \"MTX\"}, {\"ade\": \"facial swelling\", \"drug\": \"MTX\"}, {\"ade\": \"cough\", \"drug\": \"MTX\"}]",
"role": "assistant"
}
] |
Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.
|
[
{
"ade": "Secondary hyperparathyroidism",
"drug": "lithium"
},
{
"ade": "nephrotoxicity",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.",
"role": "user"
},
{
"content": "[{\"ade\": \"Secondary hyperparathyroidism\", \"drug\": \"lithium\"}, {\"ade\": \"nephrotoxicity\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.
|
[
{
"ade": "massive pulmonary bleeding",
"drug": "MMC"
},
{
"ade": "HUS",
"drug": "MMC"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.",
"role": "user"
},
{
"content": "[{\"ade\": \"massive pulmonary bleeding\", \"drug\": \"MMC\"}, {\"ade\": \"HUS\", \"drug\": \"MMC\"}]",
"role": "assistant"
}
] |
Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.
|
[
{
"ade": "progressive paraparesis",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery.",
"role": "user"
},
{
"content": "[{\"ade\": \"progressive paraparesis\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
Acute asthma associated with sustained-release verapamil.
|
[
{
"ade": "Acute asthma",
"drug": "verapamil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute asthma associated with sustained-release verapamil.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute asthma\", \"drug\": \"verapamil\"}]",
"role": "assistant"
}
] |
Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.
|
[
{
"ade": "hepatic reactions",
"drug": "cyclofenil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Thirty patients with hepatic reactions to cyclofenil, a non-steroidal drug with a stimulating effect on ovulation, are reviewed.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatic reactions\", \"drug\": \"cyclofenil\"}]",
"role": "assistant"
}
] |
An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.
|
[
{
"ade": "NCSE",
"drug": "ifosfamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: An objective causality assessment by use of the Naranjo probability scale revealed that NCSE due to ifosfamide was probable.",
"role": "user"
},
{
"content": "[{\"ade\": \"NCSE\", \"drug\": \"ifosfamide\"}]",
"role": "assistant"
}
] |
We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.
|
[
{
"ade": "PSA continued to decrease",
"drug": "flutamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a patient with androgen-independent prostate cancer in whom PSA continued to decrease for a period of 15 months after flutamide withdrawal.",
"role": "user"
},
{
"content": "[{\"ade\": \"PSA continued to decrease\", \"drug\": \"flutamide\"}]",
"role": "assistant"
}
] |
Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.
|
[
{
"ade": "hepatitis",
"drug": "pegvisomant"
},
{
"ade": "hepatitis",
"drug": "octreotide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Drug-induced hepatitis in an acromegalic patient during combined treatment with pegvisomant and octreotide long-acting repeatable attributed to the use of pegvisomant.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatitis\", \"drug\": \"pegvisomant\"}, {\"ade\": \"hepatitis\", \"drug\": \"octreotide\"}]",
"role": "assistant"
}
] |
Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.
|
[
{
"ade": "tachycardia",
"drug": "procainamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.",
"role": "user"
},
{
"content": "[{\"ade\": \"tachycardia\", \"drug\": \"procainamide\"}]",
"role": "assistant"
}
] |
k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.
|
[
{
"ade": "bucco-linguo-masticatory dyskinesia",
"drug": "lithium"
},
{
"ade": "akathisia",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: k bipolar manic-depressive patient, developed while on lithium prophylaxis, akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia.",
"role": "user"
},
{
"content": "[{\"ade\": \"bucco-linguo-masticatory dyskinesia\", \"drug\": \"lithium\"}, {\"ade\": \"akathisia\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.
|
[
{
"ade": "bilateral pulmonary infiltrates",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.",
"role": "user"
},
{
"content": "[{\"ade\": \"bilateral pulmonary infiltrates\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.
|
[
{
"ade": "acetazolamide intoxication",
"drug": "acetazolamide"
},
{
"ade": "Acute hemorrhagic gastritis",
"drug": "acetazolamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute hemorrhagic gastritis associated with acetazolamide intoxication in a patient with chronic renal failure.",
"role": "user"
},
{
"content": "[{\"ade\": \"acetazolamide intoxication\", \"drug\": \"acetazolamide\"}, {\"ade\": \"Acute hemorrhagic gastritis\", \"drug\": \"acetazolamide\"}]",
"role": "assistant"
}
] |
We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.
|
[
{
"ade": "anaemia",
"drug": "Zidovudine"
},
{
"ade": "bone marrow aplasia",
"drug": "Zidovudine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.",
"role": "user"
},
{
"content": "[{\"ade\": \"anaemia\", \"drug\": \"Zidovudine\"}, {\"ade\": \"bone marrow aplasia\", \"drug\": \"Zidovudine\"}]",
"role": "assistant"
}
] |
Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.
|
[
{
"ade": "Dilated cardiomyopathy",
"drug": "adrenaline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.",
"role": "user"
},
{
"content": "[{\"ade\": \"Dilated cardiomyopathy\", \"drug\": \"adrenaline\"}]",
"role": "assistant"
}
] |
Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.
|
[
{
"ade": "acute pancreatitis",
"drug": "tigecycline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Pancreatitis has been associated with the tetracycline class of antibiotics and concerns about tigecycline-induced acute pancreatitis have recently been raised.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute pancreatitis\", \"drug\": \"tigecycline\"}]",
"role": "assistant"
}
] |
Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.
|
[
{
"ade": "Neurologic toxicity",
"drug": "FUdR"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Neurologic toxicity associated with hepatic artery infusion HAI of FUdR.",
"role": "user"
},
{
"content": "[{\"ade\": \"Neurologic toxicity\", \"drug\": \"FUdR\"}]",
"role": "assistant"
}
] |
Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.
|
[
{
"ade": "Vitiligo",
"drug": "alpha-interferon"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Vitiligo associated with alpha-interferon in a patient with chronic active hepatitis C.",
"role": "user"
},
{
"content": "[{\"ade\": \"Vitiligo\", \"drug\": \"alpha-interferon\"}]",
"role": "assistant"
}
] |
Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.
|
[
{
"ade": "cardiovascular collapse",
"drug": "flecainide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Managing cardiovascular collapse in severe flecainide overdose without recourse to extracorporeal therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiovascular collapse\", \"drug\": \"flecainide\"}]",
"role": "assistant"
}
] |
Methotrexate induced sprue-like syndrome.
|
[
{
"ade": "sprue-like syndrome",
"drug": "Methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Methotrexate induced sprue-like syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"sprue-like syndrome\", \"drug\": \"Methotrexate\"}]",
"role": "assistant"
}
] |
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.
|
[
{
"ade": "Fracture of the femoral neck",
"drug": "PSL"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.",
"role": "user"
},
{
"content": "[{\"ade\": \"Fracture of the femoral neck\", \"drug\": \"PSL\"}]",
"role": "assistant"
}
] |
Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.
|
[
{
"ade": "hepatic toxicity",
"drug": "HU"
},
{
"ade": "mild reversible hematologic",
"drug": "HU"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatic toxicity\", \"drug\": \"HU\"}, {\"ade\": \"mild reversible hematologic\", \"drug\": \"HU\"}]",
"role": "assistant"
}
] |
We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.
|
[
{
"ade": "cytotoxic edema",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.",
"role": "user"
},
{
"content": "[{\"ade\": \"cytotoxic edema\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.
|
[
{
"ade": "enlargement of spontaneous hemorrhage",
"drug": "aspirin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: On the other hand, aspirin may have promoted the enlargement of spontaneous hemorrhage from meningioma.",
"role": "user"
},
{
"content": "[{\"ade\": \"enlargement of spontaneous hemorrhage\", \"drug\": \"aspirin\"}]",
"role": "assistant"
}
] |
There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.
|
[
{
"ade": "symptomatic cardiac failure",
"drug": "doxorubicin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: There is a dose-effect relationship between doxorubicin and the incidence of symptomatic cardiac failure.",
"role": "user"
},
{
"content": "[{\"ade\": \"symptomatic cardiac failure\", \"drug\": \"doxorubicin\"}]",
"role": "assistant"
}
] |
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