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6,207,705 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:29:28.651Z | 2001-10-01T00:00:00.000 | Screening of rotavirus and adenovirus infections during prolonged hospitalization in a neonatal unit | Rotavirus and adenovirus infections in 308 infants hospitalized for longer than 1 wk, and cases with necrotizing enterocolitis, were screened in a neonatal unit during a 15 mo period, covering two rotavirus epidemics in the community. Altogether, 1020 stool samples were collected weekly until hospital discharge, and in necrotizing enterocolitis cases at the onset of symptoms, and tested for rotavirus and adenovirus by means of enzyme‐linked immunosorbent assay. The positive samples were further analysed by polymerase chain reaction. Enzyme‐linked immunosorbent assay revealed five adenovirus‐positive cases, which were tested negative by polymerase chain reaction. Out of 16 necrotizing enterocolitis cases, one was adenovirus‐ and another rotavirus positive when tested by polymerase chain reaction, the latter having a concomitant Candida albicans septicaemia. | e1dd57ec6f8216b97c70325125106fbf02c31c0a | Medline, Unpaywall, MAG, Wiley, MergedPDFExtraction | Medicine | Medicine | DOI:10.1111/j.1651-2227.2001.tb03254.x, MAG:2099871677 |
251,269,455 | pes2o/s2ag | v3-fos-license | 2022-08-03T15:20:22.304Z | 2022-04-15T00:00:00.000 | Improve a secure blind watermarking technique for digital video | In recent years, digital watermark video has become increasingly popular in a range of industries, but because it is widely available on the Internet, it is simple to make unlawful copies and tamper with digital video. Watermarking digital video has become more popular as a method of detecting changes and preventing illegal duplication. This paper presents a video copyright protection system that is secure, blind, and robust. Two approaches that are resistant to diverse attacks are proposed in this research. The initial step is to encrypt a hybrid watermark (Message, Image) using two different encryption techniques (RSA and AES). The second is a steganography technique based on LSB-based robust watermarking, which embeds an encrypted secret bit Message and Image in key frames of an MP4 video file by utilizing the mean of the grayscale images that differ and take the most significant differences between the two images. The intensity of the histogram will become more consistent across all pixels as the encryption quality improves. For keyframe watermarking in the spatial domain, the proposed methods can maintain the watermarked information while achieving high imperceptibility and a Peak Single to Noise Ratio [PSNR] equivalent to more than 50 db, where quality measures (MSE, PSNR, and correlation coefficient) that calculate the levels of distortion caused by embedding a watermark in digital video produce good results. | ec0fc2d3d0dfc88d149988e708a6c60f99e14f9a | MergedPDFExtraction, Anansi, Crossref, ScienceParsePlus | Computer Science | null | DOI:10.21533/pen.v10i2.2859 |
199,467,099 | pes2o/s2ag | v3-fos-license | 2019-08-08T13:13:49.850Z | 2019-08-07T00:00:00.000 | Fertility quality of life tool: update on research and practice considerations | Abstract The 36-item Fertility Quality of Life (FertiQoL) tool is increasingly used in research and practice. It measures quality of life in four personal domains (emotional, social, relational, mind/body) and two treatment domains (tolerability, environment). A literature review of published empirical research using FertiQoL was undertaken to provide an overview of this research base. Five databases were searched using ‘FertiQoL’ and its variant. In total, 41 published articles from 35 independent samples in 23 countries involving 16,315 participants, mainly in clinical settings, were reviewed. FertiQoL was used for three main purposes: (i) to assess quality of life and FertiQoL measurement properties (especially Core FertiQoL) using cross-sectional designs; (ii) to identify correlates, predictors, and consequences of fertility quality of life (some of which included international comparisons); (iii) to assess the effect of psychological interventions on fertility quality of life. The range of median FertiQoL Core, Treatment and subscale (scaled) scores in 31 samples was between 60 and 75. Poorer fertility quality of life was consistently associated with being a woman, longer duration of infertility, poorer psychological functioning and lower patient–centred care. Some FertiQoL subscale scores improved after psychological interventions. Future research should address measurement issues and examine reported associations with fertility quality of life. | 96940d725cc3b441ecde0050edde8cdfe3370e4b | Crossref, Anansi, MergedPDFExtraction, Unpaywall, ScienceParsePlus, TaylorAndFrancis, Medline, MAG | Medicine, Psychology | Medicine, Psychology | DOI:10.1080/14647273.2019.1648887, MAG:2965962465 |
29,932,755 | pes2o/s2ag | v3-fos-license | 2017-12-20T18:40:03.313Z | 2017-04-01T00:00:00.000 | Performance comparision of MUSIC and ESPRIT algorithms in presence of coherent signals for DoA estimation | A novel methodology is implemented for detection of coherent signals in direction of arrival estimation of linear arrays. The available techniques for DoA estimation of incoherent signal is modified by introducing spatial smoothing technique. This spatial smoothing technique is further used to de-correlate the signals before applying MUSIC algorithm for DoA estimation. DoA estimation is also performed using ESPRIT algorithm for linear array and Performance of MUSIC and ESPRIT algorithms is compared on basis of Computational time required and resolution of DoA estimated. ESPRIT is found to be a better choice than MUSIC for DoA estimation. | d635cf79d1ebaabb4e256b2b9752a10625f01905 | Unpaywall, MAG, ScienceParseMerged, IEEE | Business | Computer Science | DOI:10.1109/ICECA.2017.8212844, MAG:2775620157 |
22,620,805 | pes2o/s2ag | v3-fos-license | 2017-02-10T06:27:13.004Z | 2004-06-07T00:00:00.000 | Power comparison between high-speed electrical and optical interconnects for inter-chip communication | Power dissipation between electrical and optical interconnects for high-speed inter-chip communication is compared. A power minimization strategy for optical interconnects is developed and its scaling trends are shown. Optical interconnect when compared with the state-of-the-art electrical interconnect yields lower power beyond a critical length (43cm at 6Gb/s and 100nm technology node). The critical length is fully characterized as a function of system requirements (bit rate and bit-error rate) and interconnect's end-device parameters (detector capacitance, receiver sensitivity and offset). Higher bit rates yield lower critical lengths making optical interconnects more favorable in the future. | 0729c23a9cd76da2ff07e24d9bc7d324bda0033c | IEEE, MAG, Unpaywall | Physics | Materials Science | DOI:10.1109/IITC.2004.1345710, MAG:2132367900 |
270,798,005 | pes2o/s2ag | v3-fos-license | 2024-06-29T13:18:44.992Z | 2024-05-20T00:00:00.000 | The Need for Transforming Business Models in Insurance Using AI – Case Study | We already adopted the fact that digital transformation is happening in all sectors, even financial such as insurance, but fact that software is taking over some important processes in businesses made us consider using AI. We can see how AI is disrupting the business of various sectors in practice. The insurance sector is also being disrupted by the advent of AI. In this paper, we will describe a traditional insurance process, with a look at the specific innovations that AI is introducing in the insurance industry itself and see how it is possible to use AI in local insurance company. Although insurance fraud is the most common form of use of artificial intelligence, this paper will emphasize that artificial intelligence can automatically analyze large amounts of data, identify patterns, and make quick decisions, which can lead to optimization of business processes and cost reduction. The insurance industry is going through similar problems as other industries, but it has its own specifics since insurance is a highly regulated area by regulatory agencies and business outside the framework of the home countries. In this paper we will emphasize the fact that we need new skills, especially for using specialized AI tools in the desire to transform any business model. We will use the case of the insurance company from Bosnia and Herzegovina. | 6f9c51c77d152b9e5beba4459fad72721c36da3a | Crossref, DBLP, IEEE, ScienceParsePlus | Business, Computer Science | null | DOI:10.1109/MIPRO60963.2024.10569701 |
38,858,443 | pes2o/s2ag | v3-fos-license | 2018-04-03T04:23:53.498Z | 1994-08-01T00:00:00.000 | High Glucose Attenuates Peptide Agonist-Evoked Increases in Cytosolic Free [Ca2+] in Rat Aortic Smooth Muscle Cells | Incubation of cultured rat aortic smooth muscle cells (ASMCs) in a medium containing high glucose concentrations (25 mM) did not affect the basal cytosolic free calcium ([Ca2+]i) but led to significant reductions in peak [Ca2+]i response evoked by arginine vasopressin, angiotensin II, and endothelin-1 (ET-1). This was observed in both the presence and absence of extracellular Ca2+. Maintenance of rat ASMCs in a medium containing mannose (an osmotic control for high glucose) did not affect either the basal or peptide agonist-evoked increase in [Ca2+]i. However, pretreatment with either the nonselective protein kinase C (PKC) inhibitor staurosporine or the selective PKC inhibitor 2,6-diamino-N-([1-(1-oxotridecyl)-2 piperidinyl] methyl) hexanamide reversed the attenuating effect of high glucose on peak [Ca2+]i response evoked by ET-1. Also, short-term incubation of ASMCs with the active phorbol ester, phorbol 12-myristate 13-acetate, led to a reduction in peak [Ca2+]i response to all three agonists, whereas the inactive phorbol ester, 4α-phorbol 12,13-didecanoate, which does not activate PKC, had no such effect. Although high-glucose treatment of rat ASMCs led to significant reductions in the maximal number of binding sites to the extent of 39% of [125I]ET-1 specific binding, no significant differences in the affinity (Kd ∼110 pM) characteristics were evident between control and high-glucose treatment groups. It is proposed that incubation of rat ASMCs with high glucose enhances the de novo synthesis of diacylglycerol and activates membrane-bound PKC and that this, in turn, impairs agonist-mediated intracellular Ca2+ mobilization. | d4c9250e7964eeaff78c3f823766eb274ecd42aa | Highwire, Medline, MergedPDFExtraction, MAG, Unpaywall | Biology | Biology, Medicine | DOI:10.2337/diab.43.8.1033, MAG:2143480749 |
23,329,643 | pes2o/s2ag | v3-fos-license | 2018-04-03T02:52:53.524Z | 2001-04-01T00:00:00.000 | NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia | The role of the BCR‐ABL fusion gene in the pathogenesis of the chronic phase of chronic myelogenous leukemia (CML) has been well established. Several additional genetic changes have been reported to occur, at varying frequencies, during disease progression to “accelerated” and “blast crisis” phases. The NUP98 gene localized to chromosome band 11p15 has been found at the breakpoints of several distinct chromosomal translocations in patients with both de novo and therapy‐related myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML). Using combined cytogenetic and molecular analyses, we have found rearrangements of the NUP98 gene in the leukemic cells of two patients with Philadelphia chromosome–positive CML, during disease evolution. As expected, analysis of the t(7;11)(p15;p15) from one of the patients showed an in‐frame NUP98‐HOXA9 fusion. The fusion points were similar to previously reported NUP98‐HOXA9 fusion points from patients with MDS/AML. Our results indicate that the NUP98 gene is an additional, albeit infrequent, genetic target during clonal evolution of CML. © 2001 Wiley‐Liss, Inc. | 03cf247ee36cba45235748b80f3bfb97103dc08f | MergedPDFExtraction, MAG, Unpaywall, Wiley, Medline | Biology | Biology, Medicine | DOI:10.1002/1098-2264(2001)9999:9999<::AID-GCC1108>3.0.CO;2-9, MAG:2000777582 |
24,392,393 | pes2o/s2ag | v3-fos-license | 2017-07-29T04:19:25.568Z | 1979-07-01T00:00:00.000 | A Revision of the genus Wislizenia (Capparidaceae) based on population studies | Morphological and cytological studies of mass collections from the southwestern United States and Baja California, and morphological studies on herbarium specimens from these areas and northern Mexico have been used to solve a taxonomic problem within the genusWislizenia. Canonical analysis of morphological data from mass collections separates three geographic groups from: California, Baja California, and states east of California. A similar analysis of herbarium specimens collected throughout the range ofWislizenia refracta confirms the reality of these groups, for which the status of subspecies is proposed: 1) subsp.californica from the California central valley, 2) subsp.palmeri from Baja California and the Sonoran coast, and 3 ) subsp.refracta from states east of California. This taxonomic treatment differs from any of the varied previous ones. Chromosome numbers for six of the mass collections were found to ben = 20, in agreement with other reports. | a40ed093d2f00d3094cdf11f3c8394bffef704de | MAG, ScienceParseMerged, Unpaywall, Springer, SpringerNature | Biology | Geography | DOI:10.2307/2806125, MAG:2065380705 |
20,494,407 | pes2o/s2ag | v3-fos-license | 2017-08-14T22:38:30.723Z | 1999-03-01T00:00:00.000 | Medical negligence and the NHS: an economic analysis. | Medical negligence was estimated to cost the NHS in England 235m pounds sterling in 1996/1997, growing at rate of up to 25% per annum. Yet analysis of NHS accounts suggest that a change in accounting policy has led to growth rates and recurrent expenditure on medical negligence being over estimated. The main concern, however, is total societal cost, not the accounting cost to the NHS. The objective of policy should be to ensure that cost-effective investment in injury prevention takes place. Measures that simply shift cost to other social budgets or onto patients are not helpful. NHS arrangements changed in the 1990s with Trusts taking responsibility for claims against hospital doctors and a new NHS Litigation Authority providing insurance for Trusts. It is unclear, however, whether Trusts have had either the incentives or the ability to implement effect risk management policies. Estimates based on two US studies and one UK study suggest that negligence in the NHS in England may cause around 90000 adverse events per year involving 13500 deaths, but only resulting in around 7000 claims and 2000 payments. A priority must be the establishment of a comprehensive national database of claims information. Other policy measures are proposed to reinforce the incentives on Trusts and doctors to implement cost-effective risk management policies. | db46518dab89ff2d12933b2c81acb758e07cd557 | Anansi, ScienceParseMerged, Medline, Unpaywall, MAG | Economics, Medicine | Economics, Medicine | DOI:10.1002/(SICI)1099-1050(199903)8:2<93::AID-HEC419>3.0.CO;2-G, MAG:2094847123 |
38,533,647 | pes2o/s2ag | v3-fos-license | 2019-03-21T13:05:54.035Z | 2003-01-01T00:00:00.000 | Treatment of transfusion‐dependent thalassemic patients infected with hepatitis C virus with interferon α‐2b and ribavirin | Because of their lifelong requirement for blood transfusions, the vast majority of patients with thalassemia major born before the introduction of hepatitis C virus (HCV) screening of blood donors have been infected with this virus. Significant liver disease may occur related to the combination of chronic HCV infection and hepatic siderosis. Currently, the most effective licensed treatment for chronic HCV infection is combination therapy with interferon alfa (either pegylated or nonpegylated) and ribavirin.1 An almost universal effect of ribavirin is the occurrence of hemolysis and, according to the product monograph, this therapy should not be used in patients with hemoglobinopathies including thalassemia.2 We have treated three HCV-infected female thalassemic patients with significant hepatic fibrosis on liver biopsy with standard dose combination therapy (interferon -2b 3 MU subcutaneously three times a week and ribavirin 1,000 mg orally per day; Rebetron, Schering). Four additional thalassemic patients positive for HCV antibody were evaluated and not treated either because they were repeatedly nonviremic (2 patients) or because they refused antiviral therapy (2 patients). All patients tolerated treatment well with no dose modifications or premature withdrawals. Patients’ blood counts were monitored weekly for the first month and then every 2 to 3 weeks. They were transfused as required to maintain their hemoglobin levels above 9.0 g/dL. The mean increase in transfusion requirements on treatment compared with the same period of time immediately prior to treatment was 48%. Patients’ transfusion requirements returned to their pretreatment baseline within 2 months of completing antiviral therapy. All patients had undetectable HCV RNA in serum by polymerase chain reaction (Amplicor Monitor, Roche; sensitivity 50 viral copies/mL) 6 months after completion of therapy and were thus sustained virologic responders despite significant iron overload at baseline (Table 1). In summary, full dose combination therapy with interferon and ribavirin appears to be safe and effective in the treatment of chronic HCV infection in transfusion-dependent thalassemics. The increased transfusion requirements during treatment are acceptable if it is considered that these patients had already been transfused hundreds of blood units over their lifetimes. This is especially true in the context of marked hepatic fibrosis and the potential for significant longterm liverrelated morbidity.3 | fb891d4d218d6735d02dac0816679885439efb27 | Wiley, MAG, MergedPDFExtraction, Unpaywall, ScienceParsePlus | Medicine | Medicine | DOI:10.1053/JHEP.2003.50037, MAG:2011610182 |
10,202,697 | pes2o/s2ag | v3-fos-license | 2016-04-07T00:00:00.000Z | 1991-11-01T00:00:00.000 | Experiences in DBMS implementation using an object-oriented persistent programming language and a database toolkit | The EXODUS database toolkit, and in particular the E persistent programming language, have been used in two substantial database system implementation efforts by the authors (the Ariel database rule system and the Triton nested relation DBMS). Observed advantages of using a persistent programming language for database system implementation include ease of implementation of specialpurpose persistent objects used by the DBMS such as catalogs, data indexes, rule indexes, and nested relational structures. Other advantages of using E (a persistent version of C++) that are independent of the persistence issue are the usefulness of objectoriented programming in developing large software systems, and the utility of the Collection abstraction in E. Observed disadvantages include (1) the inability to map the type system of the DBMS to the type system of the underlying programming language while still retaining good performance for tEric Hanson is with the Artificial Intelligence Technology Office (WL/AAA-l), Air Force Wright Laboratory, Wright-Patterson AFB, OH 45433, and with Wright State University. His work was supported in part by the Air Force Office of Scientific Research under grant number AFOSR- | b29ac97fcd4a524e43f109f6bae5eebc82e6a8fc | ACM, DBLP, Grobid, Unpaywall, ScienceParseMerged, MAG | Computer Science | null | DOI:10.1145/117954.117978, MAG:2036830468 |
22,244,955 | pes2o/s2ag | v3-fos-license | 2018-04-03T04:55:59.481Z | 2008-05-01T00:00:00.000 | Pediatric nephrology consultations in a tertiary academic center in Jordan. | To determine the conditions that result in pediatric nephrology consultations in an academic hospital setting, we studied 178 prospective consecutive consultations for 125 inpatients (69 boys and 56 girls) at the Jordan University Hospital, Amman, Jordan from January 2006 to December 2006. The mean age at the time of consultation was 3.1 years (median of 1 year, and range from 1 day to 16 years). Of the 125 patients, 87 (69.6%) patients had a single consultation, while 38 (30.4%) patients had multiple encounters (range from 1-4 consultations). The reasons for consultations included fluids and electrolytes imbalances (29.0%), hydronephrosis (15.7%), urinary tract infections (14.2%), acute renal failure (ARF) (14.2%), hypertension (8.40%), and miscellaneous conditions (18.5%). The most frequent fluids and electrolyte disorders were polyuria, hypocalcemia, and hyponatremia. Routine administration of hypotonic intravenous fluids was a major contributory factor to hyponatremia. The most frequent cause of ARF was acute tubular necrosis in association with multiple organ dysfunction and antibiotic nephrotoxicity. Hypertension was mostly neurogenic in origin. | 605aeafd2758c08e64906c49b5d629314c2038b2 | MAG, Medline | Medicine | Medicine | MAG:1571783166 |
23,523,555 | pes2o/s2ag | v3-fos-license | 2018-04-03T00:49:54.288Z | 1998-01-01T00:00:00.000 | Central, local, and overall ratings of perceived exertion during cycling and running by women with an external or internal locus of control. | Much research has been directed toward finding the most prominent psychological factors affecting ratings of perceived exertion during physical exercise. The one most frequently mentioned, although rarely investigated empirically, is locus of control. Findings from non-sport-related research indicate that individuals with an internal locus of control (internals) are better at using the available information than individuals with an external locus of control (externals). That finding has been attributed to the inferior information-processing capacity of the latter group, a deficit that might also affect the processing of exertional cues during physical exercise. In the present study, a group of women categorized as internals were compared with a similar group of externals during both ergometer cycling and treadmill running. The results indicated significantly different ratings between the groups not only for overall perceived exertion but also for local (muscles and joints) and central (cardiopulmonary) exertion. The observed differences were greater during ergometer cycling than during treadmill running. It is possible that the more distinct cues available during cycling, stemming mainly from the working muscles (local factors), presented more information to process, a task that the internals were better at than the externals. | 1495508da02cf15652ca6b0571acc4c4335af502 | MAG, Unpaywall, Medline | Psychology | Psychology, Medicine | DOI:10.1080/00221309809595573, MAG:1980854527 |
235,812,955 | pes2o/s2ag | v3-fos-license | 2021-07-14T13:29:51.274Z | 2021-07-11T00:00:00.000 | A Massively Parallel Trafficking Assay Accurately Predicts Loss of Channel Function in KCNH2 Variants | High throughput genomics has greatly facilitated identification of genetic variants. However, determining which variants contribute to disease causation is challenging with more than half of all missense variants now classified as variants of uncertain significance (VUS). A VUS leaves patients and their clinicians unable to utilize the variant information in clinical decision-making. In long QT syndrome type 2, KCNH2 channel function is directly associated with disease presentation. Therefore, functional phenotyping of KCNH2 variants can provide direct evidence to aid variant classification. Here, we investigated the expression of all codon variants in exon 2 of KCNH2 using a massively parallel trafficking assay and for a subset of 458 single nucleotide variants compared the results with peak tail current density and gating using automated patch clamp electrophysiology. Trafficking could correctly classify loss of peak tail current density variants with an AUC reaching 0.94 compared to AUCs of 0.75 to 0.8 for in silico variant classifiers. We suggest massively parallel trafficking assays can provide prospective and accurate functional assessment for all missense variants in KCNH2 and most likely many other ion channels and membrane proteins. | 141e2d701a1b8dab344e898987fdadec9857faf0 | MergedPDFExtraction, BioRxiv, Crossref | Biology | Biology | DOI:10.1101/2021.07.10.451881 |
154,463,391 | pes2o/s2ag | v3-fos-license | 2019-05-16T13:05:31.815Z | 2009-08-01T00:00:00.000 | The politics of heaven: women, gender, and empire in the study of Paul | dignity of human beings. Eichmann was a shallow person who had participated in a horrific crime. The Israelis recognised his humanity by giving him a fair trial but this did not save Eichmann from the gallows; a judgement was passed. He had forfeited his right to life, and people rightly despised him for his crimes, but throughout he remained a human being who, as such, deserved a fair hearing. Eichmann represents an extreme case but it starts us on the road of analysing what respect for persons might mean. It is too facile to say that every religious belief and every religious sect deserves to be respected or treated as ‘equally valid’. This is simply not the case. Usually there are good reasons why some are respected and others not. However, there is also an inalienable respect that we owe to everyone by virtue of their humanity. This is a basic belief that used to be expressed by saying that everyone is a child of God. To hold such basic beliefs and to differentiate them from others is to enter the field of theology. It is not so easy to get rid of theology; it might even be downright dangerous. | 7548d92965afdea1a5edd386b4e6d7b2e7d928bc | MAG, Unpaywall, TaylorAndFrancis, MergedPDFExtraction | History, Political Science | History | DOI:10.1080/13617670903175253, MAG:2120837954 |
2,331,709 | pes2o/s2ag | v3-fos-license | 2015-12-19T00:12:26.206Z | 2012-01-01T00:00:00.000 | Independence Detection for Multi-Agent Pathfinding Problems | Problems that require multiple agents to follow noninterfering paths from their current states to their respective goal states are called multi-agent pathfinding problems (MAPFs). In previous work, we presented Independence Detection (ID), an algorithm for breaking a large MAPF problem into smaller problems that can be solved independently. Independence Detection is complete and can be used in combination with both optimal and approximation algorithms. This paper serves as an introduction to Independence Detection and aims to clarify its details. | 8b6f025a3478c0779bc41ff04b4f17b0eab1aa6c | MAG, ScienceParseMerged, DBLP, Anansi, Grobid, Crawler | Computer Science | Computer Science | MAG:2794537246 |
6,577,909 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:32:10.072Z | 2000-03-28T00:00:00.000 | Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding. | Apolipoprotein C-II (apoC-II) is an exchangeable plasma apolipoprotein and an endogenous activator of lipoprotein lipase (LpL). Genetic deficiencies of apoC-II and overexpression of apoC-II in transgenic mice are both associated with severe hyperlipidemia, indicating a complex role for apoC-II in the regulation of blood lipid levels. ApoC-II exerts no effect on the activity of LpL for soluble substrates, suggesting that activation occurs via the formation of a lipid-bound complex. We have synthesized a peptide corresponding to amino acid residues 39-62 of mature human apoC-II. This peptide does not bind to model lipid surfaces but retains the ability to activate LpL. Conjugation of the fluorophore 7-nitrobenz-2-oxa-1,3-diazole (NBD) to the N-terminal alpha-amino group of apoC-II39-62 facilitated determination of the affinity of the peptide for LpL using fluorescence anisotropy measurements. The dissociation constant describing this interaction was 0.23 microM, and was unchanged when LpL was lipid-bound. Competitive binding studies showed that apoC-II39-62 and full-length apoC-II exhibited the same affinity for LpL in aqueous solution, whereas the affinity for full-length apoC-II was increased at least 1 order of magnitude in the presence of lipid. We suggest that while the binding of apoC-II to the lipid surface promotes the formation of a high-affinity complex of apoC-II and LpL, activation occurs via direct helix-helix interactions between apoC-II39-62 and the loop covering the active site of LpL. | 86c996db2ef946fae5a5aded541e762a54c664f8 | MAG, Medline, Unpaywall | Biology, Chemistry, Medicine | Chemistry, Medicine | DOI:10.1021/BI992523T, MAG:1985017566 |
46,824,759 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:24:21.010Z | 1986-01-01T00:00:00.000 | Combined cyclophosphamide and corticosteroid-induced remission in severe glomerulopathy associated with systemic vasculitis. | Three patients with systemic vasculitis and severe renal disease as major manifestations are reported. In 2 cases, rapidly progressive glomerulonephritis presented as oliguric renal failure. In the third case, the clinical picture was severe nephrotic syndrome with decreased renal function. Combined cyclophosphamide and corticosteroid treatment resulted in dramatic improvement of renal function and remission of nephrotic syndrome. In 2 cases, histological improvement was documented by repeated kidney biopsy. The optimal duration of cyclophosphamide therapy has to be determined. | 74e3a2d7bbf7ff9fc80710f74cf473372b30858f | MAG, Medline, Unpaywall | Medicine | Medicine | DOI:10.1159/000167188, MAG:2050767490 |
216,428,295 | pes2o/s2ag | v3-fos-license | 2020-04-02T09:08:24.191Z | 2020-03-13T00:00:00.000 | User Education and File Standards Best Options to Ensure Open Educational Resources are Truly Open | A Review of:
Ovadia, S. (2019). Addressing the technical challenges of open educational resources. portal: Libraries and the Academy, 19(1), 79-93. https://doi.org/10.1353/pla.2019.0005
Abstract
Objective – To describe common technical challenges of open educational resources (OERs) and recommend solutions.
Design – Descriptive study.
Setting – Online open educational resources in higher education.
Subjects – Open educational resources.
Methods – Drawing from the literature and his own experiences, the author explains the necessity of accepted standards of “openness” and describes the many ways OERs fail to meet these standards. The author also describes common technical challenges that impede openness, then proposes solutions to address these challenges.
Main Results – Technical limitations often prohibit OERs from being truly open. Providers can design their resources to encourage reuse, redistribution, revision, and remixing. Three strategies for addressing technical challenges in OERs are user education, open file standards, and using Git to facilitate distributed version control.
Conclusion – Git is a compelling option for distributed version control, but entails its own technical challenges. User education and established open file standards are the best strategies to ensure that OERs are open in both a legal and a technical sense. The article concludes with the author’s opinions about how OER directors may most realistically implement these solutions. | 5a4de5c55953085fe1f788f3e2abb022bdeab461 | Crossref, MAG, Unpaywall | Education, Computer Science | Computer Science | DOI:10.18438/eblip29685, MAG:3013360772 |
137,404,245 | pes2o/s2ag | v3-fos-license | 2019-04-28T13:08:59.971Z | 2007-02-02T00:00:00.000 | Effects of Thermomechanical Processing on Microstructure and Mechanical Properties Multiphase Steels Exhibiting a TRIP Effect | Effects of hot-rolling conditions on these steels are much less studied than their importance for practice would suggest. It should be emphasized that bainite transformation is the key reaction to enrich non-transformed austenite with carbon. This study was carried out in order to gain understanding of the effect of thermomechanical hot rolling on final microstructure and mechanical properties of C-Mn-Si TRIP steel. Fundamental of the transformation induced plasticity effect – TRIP is the stabilization of substantial amount of retained austenite down to the ambient temperature by thermomechanical processing and its subsequent transformation into strain induced martensite as a consequence of applied plastic deformation. The special prepared stepped specimens were rolled on laboratory tandem mill. The effects of finish rolling temperature, strain and isothermal bainite transformation temperature on mechanical properties of mentioned TRIP steel were evaluated (mechanical properties were examined with tension test). Major deformation, higher finishing rolling temperature and higher temperature of bainite hold result in drop in strength. Proportionately to the drop in strength, the ductility grows in the TRIP steel. Microstructures were examined with X-ray diffraction (retained austenite). Image analysis software was used to process SEM micrographs of structure (ferrite, bainite assessment). Plastometric testing was conducted on GLEEBLE 3800 thermo-mechanical simulator. First stage of experiment yielded stress-strain curves for various temperatures and strain rates. Gleeble 1500 was used for the remaining plastometric simulation. Specimens were reheated to austenitization temperature of 1100°C and soaked. Then they were cooled to the temperature of deformation and subsequently cooled at higher rate down to the bainitic transformation temperature (400 – 550 °C). Specimens were held at the bainitic transformation temperature and then air-cooled. Final microstructures were evaluated with respect to transformation diagrams and optical microscopy findings. Higher bainite volume fraction was found in the specimens cooled at higher cooling rate as compared with more slowly cooled specimens. | 3131c6f26b408dfc18fe399dc2985c46d79a3959 | Unpaywall, ScientificNet, MAG, MergedPDFExtraction | Materials Science, Engineering | Materials Science | DOI:10.4028/www.scientific.net/MSF.539-543.4357, MAG:2001413426 |
209,707,045 | pes2o/s2ag | v3-fos-license | 2019-11-22T00:33:54.619Z | 2019-11-16T00:00:00.000 | Design, Synthesis and Molecular Docking Studies of Novel Pyrazole
Benzimidazole Derivatives as Potent Antibacterial Agents | A novel series of pyrazole benzimidazole derivatives were synthesized and the structure of the final targets 4a-h were confirmed by IR, Mass, 13C NMR and 1H NMR spectral analysis. The new pyrazole core with imidazole and benzimidazoles derivatives were evaluated for in vitro antibacterial, antifungal activity against six bacterial strains significantly. In dispersion, 4c, 4f and 4g had the highest antibacterial activities on these microorganisms Bacillus subtilis B29, Escherichia coli E266, with zone of inhibition
21, 19 and 19 mm, respectively. Compounds 4a, 4c, 4h shows good antifungal activity against A. niger, Fusarium oxysporum fungal strains. Further, molecular docking for protein ligands interactions was performed using the crystal structure of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus complexed with bisphosphonate BPH-700. Among the final compounds 4e, 4g and 4h show highest binding energy ΔG = -7.89, -7.48 and -7.08 Kcal/mol, respectively and amino acid interactions Lys273, Asp27. | 375dcc6f0bc0a192f63a3ab905021d0d0592b119 | Crossref, MAG, Unpaywall | Chemistry, Medicine | Chemistry | DOI:10.14233/ajchem.2019.22137, MAG:2984119541 |
259,865,445 | pes2o/s2ag | v3-fos-license | 2023-07-15T15:08:20.871Z | 2023-07-13T00:00:00.000 | Investigation of the corrosion behavior of 6082 aluminum alloy in deicing salt | The corrosion behavior of 6082 aluminum alloy in deicing salt was investigated by electrochemical impedance spectra combined with an X‐ray diffractometer, scanning electron microscopy, electron backscatter diffraction, and transmission electron microscope. The experiment results showed that the corrosion tendency of 6082 aluminum alloy in deicing salt strongly depends on its different matrix and grain boundary precipitates, which also show the characteristics of transformation during the corrosion process. The Nyquist plot exhibits the characteristics of double capacitive resistance arcs, and the capacitive resistance arcs were affected by corrosion characteristics and corrosion products on aluminum alloy surface. The nucleation and development of pitting and the formation of a passive film were closely related to the Si phase in the 6082 aluminum alloy. | bfe4b666b6be6516ba8cb64dc8d5fde2b98f3f33 | Wiley, ScienceParsePlus, Crossref | Materials Science, Engineering | null | DOI:10.1002/maco.202313937 |
8,493,605 | pes2o/s2ag | v3-fos-license | 2016-01-11T18:29:14.669Z | 2011-01-01T00:00:00.000 | SkeenZone : A distributed Android chat application and extensible middleware | Mobile computing devices are becoming ubiquitous parts of everyday life. This growth opens a development space for practical applications geared towards decentralized collaboration and coordination. The mobile development platform Android provides rich APIs for interacting with and harnessing devices’ hardware components, but does not provide developers with adequate support for distributed computing. We present SkeenZone, a lightweight and extensible Java middleware framework created to enable the development of distributed mobile applications, and ChatHoc, a simple distributed Android chat application for evaluating and demonstrating our middleware’s ease of use. We describe two limitations of the Android platform that impose heavy restrictions on developers’ ability to build and test applications involving ad hoc networks. | e928c0d017c0cc97976dbb6b8f1ab08bb55f9e61 | Crawler, ScienceParseMerged, Anansi, Grobid | Computer Science | null | null |
23,599,505 | pes2o/s2ag | v3-fos-license | 2018-04-03T01:55:38.197Z | 1983-10-01T00:00:00.000 | IMMUNOCHEMICAL EVIDENCE FOR MULTIPLE CLASS I ANTIGENS CODED BY THE MHC OF THE RAT (RT1) AND THEIR DIFFERENTIAL EXPRESSION ON RED BLOOD CELLS AND LYMPHOCYTES | Five monoclonal antibodies reacting with class I MHC antigens were produced by fusing lymphocytes from WF (RT1u) rats immunized against DA (RT1a) rats with P3‐X63‐Ag8‐653 myeloma cells. Sequential immunoprecipitation studies with the mAb and the WF anti‐DA alloantiserum demonstrated the presence of four different class I molecules: all four molecules were reactive with the alloantiserum; three of them contained the determinant for mAb 155; two of the latter three molecules shared the determinants for mAb 3, 56 and 60, and one of these two molecules also contained the determinant for mAb 118. The four molecules could be isolated from the antigen preparation by sequential immunodepletion first with 118, next with 3, then with 155 and finally with the alloantiserum or by sequential absorption with affinity columns of Sepharose 4B coupled to the antibodies. The three antigens which were sequentially isolated with the mAb 118, 3, and 155, respectively, were analysed by SDS‐PAGE after digestion with Staphylococcus aureus V8 protease, and they showed differences in peptide patterns. The relative amounts of the antigens expressed on red blood cells and on lymphocytes were different based on the results of sequential isolation and indirect cellular radioimmunoassay: the antigen which reacted with both mAb 3 (and 56 or 60) and 155 was the major class I antigen on red blood cells, and the antigen which reacted with mAb 118, 3 (and 56 or 60) and 155 was the major class I antigen on lymphocytes. | 84c3aad0de8dc340c4ee50a84fbc0d331a9da7a5 | Wiley, Medline, MergedPDFExtraction, MAG, Unpaywall | Biology | Biology, Medicine | DOI:10.1111/j.1744-313X.1983.tb00350.x, MAG:2052959641 |
122,639,951 | pes2o/s2ag | v3-fos-license | 2019-04-20T13:13:30.564Z | 2010-04-01T00:00:00.000 | Rheology of Complex Fluid-Fluid Interfaces: A Unified Approach Based on Nonequilibrium Thermodynamics | Abstract Surface rheological properties affect the dynamics of vesicles, nanoparticles, emulsion droplets, foam bubbles, polymer microcapsules, liquid jets, living cells, lung avioli, thin liquid films, and many other multiphase systems. Surface rheology is therefore relevant for a wide range of disciplines in the areas of physics, chemistry, engineering, biology, and medicine. Currently used descriptions of surface rheology have a number of limitations, and in particular are hard to generalize to the large deformation regime. Data are often analyzed with constitutive equations based on straightforward generalizations of models developed for describing bulk phase rheology. Since the latter are in general designed to describe incompressible materials, they are not guaranteed to describe highly compressible interfaces correctly. Here we discuss a unified approach to surface rheology based on nonequilibrium thermodynamics (NET) that provides a consistent set of balance and constitutive equations for the unambiguous determination of surface rheological parameters, both near and far beyond equilibrium. A closer integration of experimental surface rheology and multiphase nonequilibrium thermodynamics would clearly be beneficial for both disciplines. | b89590d2c50cf4ee431a7fa7991ddccecde3d30c | MergedPDFExtraction, DeGruyter, ScienceParseMerged, MAG | Physics, Chemistry, Engineering | Physics | DOI:10.3933/applrheol-20-24380, MAG:2141064355 |
30,312,251 | pes2o/s2ag | v3-fos-license | 2018-04-03T01:40:17.715Z | 1995-07-01T00:00:00.000 | Treatment of high-grade bone sarcomas with neoadjuvant chemotherapy: the utility of sequential color Doppler sonography in predicting histopathologic response. | OBJECTIVE
The purpose of this study was to use color Doppler flow imaging to predict the response to preoperative chemotherapy in patients with Ewing's sarcoma or high-grade osteosarcomas early in treatment.
SUBJECTS AND METHODS
Color Doppler flow imaging was done in 31 patients before, during, and after chemotherapy. In each phase of treatment, semiquantitative changes in intratumoral blood flow, changes in maximum intratumoral Doppler shifts, and changes in resistive indexes of arteries feeding limbs that contained tumors relative to contralateral normal arteries were compared with the histopathologic response, as evaluated on the resected specimens.
RESULTS
Before chemotherapy, pathologic flow was found in the extraosseous component of all but two patients. Resistive indexes in arteries that fed tumors were significantly lower (p < .001) than the resistive indexes in the contralateral normal arteries. Histopathologic response could not be predicted on the basis of the initial measurements of Doppler shifts and resistive indexes taken before or after the first cycle of chemotherapy. Histopathologic response could be predicted after the second cycle of chemotherapy. After the second cycle of chemotherapy, the resistive index in the arteries that fed tumors increased in eight of nine good respondents but did not change or decreased in eight of nine poor respondents (p = .03). Lower intratumoral Doppler shifts were measured in six of 10 good respondents but also in five of 13 poor respondents (p = .07). After the full course of chemotherapy, persistent lower resistive indexes were measured in the arteries that fed tumors in all poor respondents but one. Intratumoral flow and Doppler shifts further decreased in all good respondents but one. Changes in Doppler shifts (p = .001) and resistive indexes (p < .001) were statistically significant between good and poor respondents, irrespective of the tumor type studied.
CONCLUSION
Decreased or unaltered resistive index in the arteries that feed tumors in addition to persistent intratumoral flow and high-frequency Doppler shifts after two cycles of chemotherapy suggest poor histologic response to chemotherapy in osteosarcoma and Ewing's sarcoma. An increased resistive index after two cycles is indicative of good response. | b3bcd1e327de0a322aba95dfb30b3a45d8bcb652 | MAG, Unpaywall, Medline | Medicine | Medicine | DOI:10.2214/AJR.165.1.7785571, MAG:2153002046 |
35,271,201 | pes2o/s2ag | v3-fos-license | 2018-04-03T02:48:48.708Z | 1987-06-01T00:00:00.000 | Use of the working formulation for non-Hodgkin's lymphoma in epidemiologic studies: agreement between reported diagnoses and a panel of experienced pathologists. | Independent review of slides of 668 cases of non-Hodgkin's lymphoma (NHL) by a panel of 4 experienced pathologists using the Working Formulation (WF) allowed determination of the agreement between reported diagnoses and panel review of slides. The panel agreed with the reported diagnosis of NHL in 93% of cases, but with the NHL subtype in only 55% of cases overall. The ability of the panelists to agree among themselves, however, was only slightly better than the panelists' agreement with the reported diagnosis (60% vs. 54%, respectively). Agreement of the panel with the reported subtype diagnosis varied from 14% to over 90%. The best agreement was with small lymphocytic lymphoma and follicular subtypes. Conclusions from this study are: 1) The WF functions well as common language for translation and comparison of diagnoses of subtypes of NHL. 2) Relative to time and cost involved, panel review using only light microscopy may not be useful in epidemiologic studies of NHL. 3) Small lymphocytic and follicular subtypes of NHL can be used more confidently in epidemiologic studies than can other subtypes whether the subtyping is done from abstracted reports or by panel review. | aab826982635dd83fbb2432420c3bbf8969f28d8 | MAG, Medline, Unpaywall | Medicine | Medicine | DOI:10.1093/JNCI/78.6.1137, MAG:2281061342 |
249,352,539 | pes2o/s2ag | v3-fos-license | 2022-06-05T15:09:23.422Z | 2022-03-23T00:00:00.000 | Religion and the Great Silk Road: means of communication, contours of interaction, trade | The article discusses the historical aspects of the functioning of the Great Silk Road from the point of view of the formation of world religions. The study of the formation of world religions is impossible without taking into account the study of the Great Silk Road as one of the factors of their spread. Religious topics themselves are quite difficult for objective scientific research, however, without the appropriate knowledge, religion today is perceived as a factor of fundamentalism that carries a potential danger. This perspective today dominates the mass consciousness and complicates the topic of interfaith relations, while during the period of the Great Silk Road, religion played a fundamental role and often served as a bridge between different cultures. The existing configuration along the entire length of the trade route of the Great Silk Road, i.e. China - Central Asia - the Eastern Mediterranean, continued to work according to the scheme where religion dictated its rules to politics, politics — to the economy, and the economy, in turn, strengthened or weakened religion. This closed cycle remained stable until and after the era of the Crusades and the Mongol conquests. | ea78b8992e67b3fe167a4bfeb3d7c1929e4b9304 | Crossref | History | null | DOI:10.33920/nik-02-2204-01 |
38,779,944 | pes2o/s2ag | v3-fos-license | 2018-04-03T04:23:41.640Z | 2009-04-01T00:00:00.000 | [Effects of glutamine on extracellular signal regulated kinase and p38MAPK expression in the kidney in young rats with endotoxemia]. | OBJECTIVE
Glutamine has protective effects against renal injuries. This study was designed to explore the possible mechanism underlying the protections by examining the effects of glutamine on extracellular signal regulated kinase (ERK) and p38MAPK expression in the kidney in rats with endotoxemia.
METHODS
One hundred and twenty-one 18-day-old Wistar rats were randomly injected with LPS (4 mg/kg; n=55), LPS (4 mg/kg)+glutamine (1 mL/kg) (n=55), or normal saline (control group; n=11). The two LPS groups were subdivided into five groups sacrificed at 2, 4, 6, 24 and 72 hrs after administration (n=11 each). ERK-2 and p38MAPK mRNA and protein expression in the kidney were measured by RT-PCR and immunohistochemistry.
RESULTS
Compared to the control group, the mRNA and protein expression of both ERK-2 and p38MAPK in the LPS group significantly increased 2, 4, 6, 24 and 72 hrs after administration (P<0.01), and reached a peak at 6 hrs (P<0.01). In the LPS+glutamine group, the trend of ERK-2 and p38MAPK expression was similar to the LPS group but their expression levels were significantly lower than those in the LPS group at all time points (P<0.05 or 0.01).
CONCLUSIONS
Both ERK-2 and p38MAPK expression increased in young rats with LPS-induced endotoxemia. Glutamine alleviates renal injuries possibly by decreasing the expression of both. | 38b7b7250c835565fd3723713dc55c679bf35f45 | MAG, Medline | Biology, Medicine | Biology, Medicine | MAG:2376588525 |
267,750,894 | pes2o/s2ag | v3-fos-license | 2024-02-20T06:45:07.330Z | 2024-02-18T00:00:00.000 | Communication cost in simulating unknown entangled states | We demonstrate how to universally simulate ensemble statistics of projective local measurements on any $n$-qubit state shared among $n$ observers with classical communication and shared randomness. Our technique originates from protocols designed to simulate quantum non-locality [in Horizons of the Mind, Springer, Cham (2014)] and classical simulation of quantum circuits [Phys. Rev. Lett. 115, 070501 (2015)]. The protocol preserves three crucial aspects of the simulated quantum scenario in contrast to other approaches: no involvement of additional parties, none of the observers knows the global state of the system, and local measurement settings remain undisclosed. | a90315d342ad0eacacaf6313acf6f94b3ca04722 | ArXiv, ScienceParsePlus, Crossref | Physics, Computer Science | Physics | ArXiv:2402.11610, DOI:10.1103/physreva.110.032623 |
23,227,295 | pes2o/s2ag | v3-fos-license | 2018-04-03T00:58:31.527Z | 1993-07-01T00:00:00.000 | Regulation of collagen synthesis and messenger RNA levels in normal and hypertrophic scar fibroblasts in vitro by interferon alfa‐2b | Hypertrophic scars, which commonly occur after thermal and traumatic injury of the skin, are a fibroproliferative disorder of the dermal matrix wherein components of the inflammatory process, including the fibrotic growth factor, transforming growth factor‐β, appear to activate dormant fibroblasts leading to cellular proliferation and excessive matrix synthesis. To investigate the potential beneficial role and mechanism of interferon alfa‐2b in controlling excessive collagen production in hypertrophic scar, we measured dose response, time of onset, and duration of action in hypertrophic scar fibroblasts in vitro and compared them with those of site‐matched normal fibroblasts obtained from four patients after thermal injury. Interferon alfa‐2b reduced collagen protein synthesis and type I messenger RNA levels in both hypertrophic scar and normal fibroblasts after treatment, but these changes were apparent only after approximately 72 hours. Significant reductions in collagen synthesis occurred in four pairs of normal and hypertrophic scar fibroblasts (p < 0.05), accompanied by significant reductions in type I (p < 0.05) but not type III procollagen messenger RNA. Hypertrophic scar fibroblasts recovered completely from the effects of interferon alfa‐2b on procollagen type I messenger RNA within 48 hours of cessation of treatment in contrast to normal skin fibroblasts, in which the reduction in type I procollagen messenger RNA by interferon alfa‐2b persisted beyond 72 hours after treatment. These data suggest that interferon alfa‐2b reduces collagen synthesis in both normal and hypertrophic fibroblasts but the hypertrophic fibroblast may remain less sensitive to its effects. | a7d3c483b63d86ab58527f4794f2d6c9c35d24ce | Unpaywall, MergedPDFExtraction, MAG, Medline, Wiley | Medicine | Biology, Medicine | DOI:10.1046/j.1524-475X.1993.10305.x, MAG:2009829340 |
32,025,844 | pes2o/s2ag | v3-fos-license | 2017-06-17T19:07:42.835Z | 2009-09-21T00:00:00.000 | Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. | Stem cells hold great promise as a means of treating otherwise incurable, degenerative diseases due to their ability both to self-renew and differentiate. However, stem cell damage can also play a role in the disease with the formation of solid tumors and leukaemias such as chronic myeloid leukaemia (CML), a hematopoietic stem cell (HSC) disorder. Despite recent medical advances, CML remains incurable by drug therapy. Understanding the mechanisms which govern chemoresistance of individual stem cell leukaemias may therefore require analysis at the single cell level. This task is not trivial using current technologies given that isolating HSCs is difficult, expensive, and inefficient due to low cell yield from patients. In addition, hematopoietic cells are largely non-adherent and thus difficult to study over time using conventional cell culture techniques. Hence, there is a need for new microfluidic platforms that allow the functional interrogation of hundreds of non-adherent single cells in parallel. We demonstrate the ability to perform assays, normally performed on the macroscopic scale, within the microfluidic platform using minimal reagents and low numbers of primary cells. We investigated normal and CML stem cell responses to the tyrosine kinase inhibitor, dasatinib, a drug approved for the treatment of CML. Dynamic, on-chip three-color cell viability assays revealed that differences in the responses of normal and CML stem/progenitor cells to dasatinib were observed even in the early phases of exposure, during which time normal cells exhibit a significantly elevated cell death rate, as compared to both controls and CML cells. Further studies show that dasatinib does, however, markedly reduce CML stem/progenitor cell migration in situ. | 4069ea472e9e28b51c30656ef48aab973c46dc7e | Anansi, MergedPDFExtraction, ScienceParseMerged, Medline, MAG, Unpaywall | Engineering, Medicine | Biology, Medicine | DOI:10.1039/b902083g, MAG:2148669551 |
5,019,294 | pes2o/s2ag | v3-fos-license | 2018-04-27T06:18:26.765Z | 2018-07-01T00:00:00.000 | Simultaneous analysis of multiple urinary biomarkers for the evaluation of oxidative stress by automated online in-tube solid-phase microextraction coupled with negative/positive ion-switching mode liquid chromatography-tandem mass spectrometry. | This study described an automated online method for the simultaneous determination of 8-isoprostane, 8-hydroxy-2'-deoxyguanosine, and 3-nitro-l-tyrosine in human urine. The method involves in-tube solid-phase microextraction using a Carboxen 1006 PLOT capillary column as an extraction device, followed by liquid chromatography with tandem mass spectrometry using a CX column and detection in the negative/positive switching ion-mode by multiple reaction monitoring. Using their stable isotope-labeled internal standards, each of these oxidative stress biomarkers showed good linearity from 0.02 to 2.0 ng/mL. Their detection limits (S/N = 3) were 3.4-21.5 pg/mL, and their intra- and inter-day precisions (relative standard deviations) were >3.9 and 6.5% (n = 5), respectively. This method was applied successfully to the analysis of urine samples, without any other pretreatment and interference peaks. | c1001d36444017c63b607477e393ab470babcfd5 | Unpaywall, Medline, MAG | Chemistry | Chemistry, Medicine | DOI:10.1002/jssc.201800175, MAG:2799770424 |
43,527,444 | pes2o/s2ag | v3-fos-license | 2018-04-03T05:35:25.061Z | 2014-01-01T00:00:00.000 | Green chromatographic fingerprinting: an environmentally friendly approach for the development of separation methods for fingerprinting complex matrices. | A chromatographic fingerprint is a comprehensive method that reveals the distinctive pattern of peaks across the chromatogram for a given sample. It is considered an effective strategy to assess the identity and quality of herbal materials, as well as for the control of the quality of their derived products. HPLC is the most employed technique for these purposes and it is used routinely for quality control in industry. Hence, its impact on the environment should not be neglected. This work provides a rational and generic procedure to qualitatively fingerprint complex matrices. Resource- and time-saving experimental designs were selected; an alternative safer organic solvent was tested and a time-saving and innovative response entitled the green chromatographic fingerprinting response was developed and employed. This procedure was applied in the development of chromatographic fingerprints for extracts of Bauhinia forficata and Casearia sylvestris. Moreover, the response proposed here can be combined with a complementary metric available in the literature to compare methods using different solvents. According to this, the chromatographic fingerprints developed here using ethanol as the organic solvent provided a performance better than that of reference methods in which more harmful acetonitrile or methanol were employed. | 57dd6e0dff9287a9fdf5036b23f0567795e82a87 | Unpaywall, Medline, MAG | Chemistry, Environmental Science | Chemistry, Medicine | DOI:10.1002/jssc.201300955, MAG:2159237978 |
244,707,194 | pes2o/s2ag | v3-fos-license | 2021-11-28T16:07:59.971Z | 2021-11-26T00:00:00.000 | RETRACTED: Effect of the solid retention time in the obtention of polyhydroxyalkanoates [version 1; peer review: awaiting peer review] | At the request of the authors, the article titled "Effect of the solid retention time in the obtention of polyhydroxyalkanoates" [version 1; peer review: awaiting peer review]. F1000Research 2021, 10:864 (https://doi.org/10.12688/f1000research.28852.1) has been retracted from F1000Research. Since publication of the article, the corresponding author has notified the Editorial team that this work was originally performed at University of A Coruña with the involvement of María C. Veiga and Christian Kennes, who were not notified regarding the submission of this manuscript or listed as authors. After discussion with all parties, including contact with the corresponding author’s institution, it was agreed that the article would be retracted in order to correct the academic record. As the article contains content which potentially should not have been made publicly available the content of the article has been removed. The authors apologise for this honest error. | 743e53de6f5faa7cdbdfdc0086864c5736564cf8 | Crossref | Medicine | null | DOI:10.12688/f1000research.75912.1 |
46,376,491 | pes2o/s2ag | v3-fos-license | 2018-04-03T06:19:00.558Z | 1987-03-01T00:00:00.000 | Assessment of testicular metabolic integrity with P-31 MR spectroscopy. | To evaluate the reliability of phosphorus-31 magnetic resonance (MR) spectroscopy in the assessment of acute testicular ischemia, vascular integrity, and spermatogenesis, the authors studied in vivo canine and primate testicles grouped as follows: group 1 testes (n = 8), in situ canine controls; group 2 (n = 11), canine testes subjected to warm ischemia; group 3, canine (n = 4) and primate (n = 4) testicles from hormone-treated animals. Group 1 control testicles showed high monophosphoester (MP) levels; low levels of inorganic phosphate (Pi), phosphodiester (PD), and phosphocreatine; and high levels of adenosine triphosphate (ATP). Group 2 testes revealed a time-dependent decay of MP/Pi ratios (from 2.1 to 0.70). Regeneration of ATP was noted in the acute reperfusion period. After 6 weeks of pituitary gonadotropin suppression, group 3 testes showed a significant decrease (P less than .05) in MP/PD ratios from a control level of 2.6 +/- 0.3 and a decrease in the MP/beta-ATP ratio from 2.4 +/- 0.1 to 1.8 +/- 0.3. P-31 MR spectroscopy appears to be a potential method for noninvasively assessing testicular ischemic injury and the metabolic integrity of spermatogenesis. | 053b3b6160c07e841ad7812b115e273b675b43b0 | MAG, Unpaywall, Medline | Medicine, Biology | Medicine | DOI:10.1148/RADIOLOGY.162.3.3809506, MAG:1972647264 |
206,898,741 | pes2o/s2ag | v3-fos-license | 2014-10-01T00:00:00.000Z | 2003-09-01T00:00:00.000 | Ray Differentials and Multiresolution Geometry Caching for Distribution Ray Tracing in Complex Scenes | When rendering only directly visible objects, ray tracing a few levels of specular reflection from large, low‐curvaturesurfaces, and ray tracing shadows from point‐like light sources, the accessed geometry is coherentand a geometry cache performs well. But in many other cases, the accessed geometry is incoherent and a standardgeometry cache performs poorly: ray tracing of specular reflection from highly curved surfaces, tracing rays thatare many reflection levels deep, and distribution ray tracing for wide glossy reflection, global illumination, widesoft shadows, and ambient occlusion. Fortunately, less geometric accuracy is necessary in the incoherent cases.This observation can be formalized by looking at the ray differentials for different types of scattering: coherentrays have small differentials, while incoherent rays have large differentials. We utilize this observation to obtainefficient multiresolution caching of geometry and textures (including displacement maps) for classic and distributionray tracing in complex scenes. We use an existing multiresolution caching scheme (originally developed forscanline rendering) for textures and displacement maps, and introduce a multiresolution geometry caching schemefor tessellated surfaces. The multiresolution geometry caching scheme makes it possible to efficiently render scenesthat, if fully tessellated, would use 100 times more memory than the geometry cache size. | 9a657867b3f792d7a249c755da3a350ff1981be7 | DBLP, ScienceParseMerged, Grobid, Unpaywall, Crawler, MAG, CiteSeerX, MergedPDFExtraction, Wiley, ScienceParsePlus, Anansi, AMiner | Computer Science | Computer Science | DOI:10.1111/1467-8659.t01-1-00702, MAG:2166442092 |
269,842,141 | pes2o/s2ag | v3-fos-license | 2024-05-19T15:16:39.952Z | 2024-05-16T00:00:00.000 | Sensitivity‐Adjustable Flexible Conductors Based on Liquid Metals via Magnetic Printing | The ability to shape and pattern conductors has been indispensable for manufacturing functional devices. Herein, a series of patterned liquid metals–based flexible electronics are fabricated via magnetic printing. The combination of highly conductive liquid metals and flexible photosensitive resins endows the as‐prepared devices with excellent electrical and mechanical properties, such as high electric conductivity (8 × 104 S m−1), low detection hysteresis, good durability, and environmental stability. What's more, strain‐insensitive flexible electronics can be achieved by designing the structure of liquid metal‐based conductors, and the resistance is only increased 0.13 Ω at 100% strain. Therefore, the as‐prepared liquid metals‐based flexible electronics have promising applications in stretchable conductors. | a357b69f8d2ea429c3b01e3e90a5b87c9bb33ab0 | Crossref | Materials Science, Engineering | null | DOI:10.1002/admt.202302004 |
85,567,716 | pes2o/s2ag | v3-fos-license | 2019-03-30T13:02:10.409Z | 1999-09-01T00:00:00.000 | Structure of egg‐batches of Thaumetopoea pityocampa (Den. and Schiff.) (Lep., Thaumetopoeidae), egg parasitoids and rate of egg parasitism on the Iberian Peninsula | In four regions of the Iberian Peninsula 273 egg‐batches of the pine processionary moth were collected after hatching of the caterpillars in 1991 and 1992. After collection, the batches were stored singly in test tubes closed with foam stoppers under laboratory conditions at 20–25°C. The number of eggs in each egg‐batch varied between 37 and 312 and the length of the batches between 0.6 and 4.2 cm. Independently of the pine species infested, seven to nine rows of eggs were counted, wrapped around one pair of needles. A correlation was found between number of eggs and the product of number of egg rows and length of egg‐batches (82% < r2 < 97%). Oviposition almost always started from the base towards the tip of the needles. The egg parasitoids that emerged were counted daily, removed and identified. Later in the year of oviposition, after the end of the period of emergence of the parasitoids, the scale cover of the egg‐batches were removed. One year later, all eggs were opened and the contents, such as parasitoid meconia and remains of caterpillars, were determined. The hatching rate of the caterpillars varied from 47.2 to 79.7%. The rate of parasitism fluctuated between 11.3 and 31.7%, but 44% of parasitoids died before successful emergence. Four species of Chalcidoidea were identified: Baryscapus servadeii (Dom.), Ooencyrtus pityocampae (Mercet), Anastatus bifasciatus (Fonsc.) and Trichogramma sp. Baryscapus servadeii and O. pityocampae were the most abundant species, followed by Trichogramma sp. Baryscapus servadeii emerged mainly in June and O. pityocampae in April or June, depending on the region. For A. bifasciatus only males, and for B. servadeii females emerged except one male. In O. pityocampae, a relatively high percentage of males (5.4–10.4%) was found. | 0eafe587b7b750b12c8f998a2c59ebc8ee732d27 | MergedPDFExtraction, MAG, Wiley, Unpaywall | Biology, Environmental Science | Biology | DOI:10.1046/j.1439-0418.1999.00405.x, MAG:2118299207 |
231,714,785 | pes2o/s2ag | v3-fos-license | 2021-01-27T14:11:24.362Z | 2020-09-23T00:00:00.000 | Fuzzy Portfolio Optimization Problem Under Uncertainty and Its Solution | The problem of constructing an optimal portfolio of securities under uncertainty is considered in paper. In this work the fundamentals of novel theory of investment portfolio optimization under uncertainty is presented based on fuzzy set theory and efficient forecasting methods. The direct problem of fuzzy portfolio optimization and dual problem are considered. In the direct problem structure of a portfolio is determined which will provide the maximum profitability at the given risk level.. The modified fuzzy portfolio optimization problem is also suggested in which maximum profitability is searched under constraint on portfolio volatility. Its model was constructed and solution suggested. The experimental investigations of the suggested fuzzy portfolio models were carried out and comparison with classical portfolio model by Markowitz was performed. | 802af88513147beca310eb938483f354336a117f | IEEE, Crossref, MAG, DBLP, MergedPDFExtraction, ScienceParsePlus | Computer Science | Computer Science | DOI:10.1109/CSIT49958.2020.9322025, MAG:3124893074 |
16,890,385 | pes2o/s2ag | v3-fos-license | 2014-10-01T00:00:00.000Z | 1997-09-01T00:00:00.000 | Dust Evolution in Protoplanetary Accretion Disks | We have numerically investigated the dust evolution in a protoplanetary accretion disk which is described by a time-dependent one-dimensional (radial) α -model. The coagulation of particles due to cohesive collisions is calculated by solving the non-linear Smoluchowski equation. The feedback of the dust evolution and the related opacity changes to the disk evolution is explicitly treated. Three different regimes during the evolution of the grain population can be identified. | 9e43da5c979d70dc0fb44203bd6c99fb892cab47 | MAG, Grobid, Unpaywall, ScienceParseMerged, CiteSeerX, Anansi | Physics, Geology | Physics | DOI:10.1017/S0252921100043621, MAG:2893439490 |
121,447,236 | pes2o/s2ag | v3-fos-license | 2019-04-19T13:12:10.881Z | 2015-02-27T00:00:00.000 | Bend insensitive graded index multimode polymer optical waveguides fabricated using the Mosquito method | We fabricate low-loss graded index (GI) circular core multimode polymer optical waveguides with 90o bending and demonstrate low bending loss even if the bend radius is as small as 1 mm. In the several fabrication methods for GI-core polymer waveguides already proposed, we adopt the “Mosquito method” that utilize a microdispenser because the Mosquito method makes it possible to fabricate waveguides directly on board at desired places on a printed circuit board, and to draw various patterns of cores including curves. However, in the waveguides including such curved cores, the additional transmission loss due to the bending (bending loss) is a concern. Thus, we characterize the fabricated GI-core polymer waveguides with bending: using two kinds of cladding monomer with different refractive indexes for fabricating waveguides with bending. We found when the NA of waveguides was as high as 0.35, no additional loss due to bending was observed even if the bending radius is as small as 1 mm. The core diameter of the fabricated waveguides is 50 μm, and it is possible to further decrease the bending loss in the waveguides with smaller core diameter. Furthermore, utilizing the Mosquito method, we fabricate waveguides with not only horizontally curved cores but also vertically curved ones. Waveguides with vertically curved cores could make it possible to realize three-dimensionally optical wiring applicable to on-board optical interconnects. | 7f1a4e7086b3ac77abd8143284b0ad19d17d6e8d | ScienceParseMerged, MAG, SPIE, Unpaywall | Physics, Engineering, Materials Science | Materials Science, Engineering | DOI:10.1117/12.2078880, MAG:2059233235 |
245,640,936 | pes2o/s2ag | v3-fos-license | 2022-01-03T16:18:29.182Z | 2022-01-07T00:00:00.000 | Combined PGT for Breast Cancer and Other Inherited Conditions | Inherited cancer predisposition is presently one of the major indications for preimplantation genetic testing (PGT), providing an option for couplers at risk to avoid the birth of an offspring with predisposition to cancer. We present here our experience of 35 of 874 PGT cycles for cancer, in which in addition to BRCA1/2 the couples were at risk to another genetic conditions as well, for which PGT was performed together with PGT for breast cancer. This resulted in in birth of 20 mutation free children with not only unaffected for the tested genetic condition, but also without risk of developing cancer. This is a part of our overall PGT series of 6,204 PGT cases for monogenic disorders (PGT-M), with 2,517 resulting births, free of genetic disorder. The accumulated experience, demonstrates considerable progress in using PGT for avoiding the birth of affected children together with avoiding predisposition to cancer. | 28a2c130bee3add55c7846bbb91f033dd76979d4 | Crossref | Medicine | null | DOI:10.31579/2578-8965/112 |
268,080,109 | pes2o/s2ag | v3-fos-license | 2017-02-11T09:26:25.566Z | 2007-09-01T00:00:00.000 | Iterative joint tone-interference cancellation and decoding for MIMO-OFDM | In this paper, multi-input multi-output orthogonal frequency-division multiplexing (MIMO-OFDM) is considered under the effects of both multipath fading and multi-tone interference (MTI). The MIMO-OFDM system makes joint use of channel and orthogonal space-frequency block coding (OSFBC) on the transmit side and iterative processing on the receiver side for robustness and improved performance against the fading and MTI effects of the channel. The new iterative receiver is implemented by either an optimal a posteriori probability (APP) space-frequency detector (SFD) or a soft information-aided minimum mean-squared error (MMSE) combiner at its front-end and a soft input-soft output (SISO) channel decoder at its back-end. Both receivers are compared in terms of their computational complexities and bit-error rate (BER) performances. Both iterative receivers provide a improvement in performance after only a few detection/decoding iterations. Also, despite its subopti-mality, the MMSE receiver achieves a BER performance close to that of the APP detector at a significantly lower cost. | 5058ac3aded18a093e58f8861bbd9d05efcbfe19 | ScienceParseMerged, Grobid, DBLP, MAG, IEEE | Engineering, Computer Science | Computer Science | MAG:1587680708 |
52,184,398 | pes2o/s2ag | v3-fos-license | 2018-09-16T06:22:59.998Z | 2016-11-01T00:00:00.000 | [Research on Water Quality Analysis Model with PCA Method and UV Absorption Spectra]. | Using the UV absorption spectrum to detect Organic pollutants content in water has become one of the most important methods for real-time online monitoring in the field of water quality inspection, however, the water complex and unstable components often bring much uncertain offset to the standard test. In this paper, water samples were classified firstly by analyzing UV absorption spectrum ranging from 200 nm to 400 μm including the organic substances, through the way of combining principal component analysis (PCA) with Euclidean distance. In this paper, we compared the Principal component analysis combined with partial least squares regression (PCA-PLSR) and the direct multi-wavelength absorption models combined with partial least squares regression (MWA-PLSR), not only for the real water sample but also for the analysis of different concentrations of COD standard solution. The result indicates that the measurement errors of the PCA is less than 5%, it is the smallest by using the first and second principal components as regression parameters for PLSR. Using the methods above can simultaneously achieve to classify of water samples and to measure the concentration of water quality parameters more accurately. | f97e1b5a834cdcb679877feea838ce0ab146158c | MAG, Medline | Environmental Science | Medicine, Chemistry | MAG:3025597638 |
247,262,090 | pes2o/s2ag | v3-fos-license | 2022-03-08T17:00:18.485Z | 2022-03-03T00:00:00.000 | Magnetic driven tentacles for bio-mimic motion | In this paper, we introduce our developed magnetically actuated artificial tentacles. Tentacles are found in nature, for example, in cuttlefish, octopus, and jellyfish. These natural tentacles have flexibility without skeletons or joints and can move in complex ways. In the present work, we propose an actuation system for the complicated motion of the tentacles and developed a method to fabricate an artificial tentacle composed of a silicone elastomer and hard magnetic particles. The present tentacles could be actuated and controlled by an applied rotating magnetic field. A 2-dimensional simulation system was also developed to predict the motion of the artificial tentacles. The simulated results showed good agreement with experimental data. Finally, an artificial tentacle was prepared to show that the tip of the structure was controlled to draw some motion. A periodic circular motion was demonstrated as an example. | cca75be05784ff272ce5d4ba108c9297a0093f34 | Crossref, MergedPDFExtraction, ScienceParsePlus, IOP | Engineering | null | DOI:10.35848/1347-4065/ac5a99 |
22,769,682 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:00:52.765Z | 2010-04-23T00:00:00.000 | Inter‐specific gene flow dynamics during the Pleistocene‐dated speciation of forest‐dependent mosquitoes in Southeast Asia | Tropical forests have undergone repeated fragmentation and expansion during Pleistocene glacial and interglacial periods, respectively. The effects of this repeated forest fragmentation in driving vicariance in tropical taxa have been well studied. However, relatively little is known about how often this process results in allopatric speciation, since it may be inhibited by recurrent gene flow during repeated secondary contact, or to what extent Pleistocene‐dated speciation results from ecological specialization in the face of gene flow. Here, divergence times and gene flow between three closely‐related mosquito species of the Anopheles dirus species complex endemic to the forests of Southeast Asia, are inferred using coalescent based Bayesian analysis. An Isolation with Migration model is applied to sequences of two mitochondrial and three nuclear genes, and 11 microsatellites. The divergence of An. scanloni has occurred despite unidirectional nuclear gene flow from this species into An. dirus. The inferred asymmetric gene flow may result from the unique evolutionary adaptation of An. scanloni to limestone karst habitat, and therefore the fitness advantage of this species over An. dirus in regions of sympatry. Mitochondrial introgression has led to the complete replacement of An. dirus haplotypes with those of An. baimaii through a recent (∼62 kya) selective sweep. Speciation of An. baimaii and An. dirus is inferred to have involved allopatric divergence throughout much of the Pleistocene. Secondary contact and bidirectional gene flow has occurred only within the last 100 000 years, by which time the process of allopatric speciation seems to have been largely completed. | ec212f783079ac5c7a81b3995d568f1174acbba5 | MAG, Wiley, Medline, Unpaywall, ScienceParseMerged, MergedPDFExtraction | Biology | Biology, Medicine | DOI:10.1111/j.1365-294X.2010.04635.x, MAG:2918459420 |
43,901,884 | pes2o/s2ag | v3-fos-license | 2018-04-03T05:42:19.868Z | 1993-12-01T00:00:00.000 | Vestibular and audiometric consequences of blast injury to the ear. | The effects of blast on the middle ear and cochlea are well documented. Vestibular damage resulting from blast is generally considered to be uncommon and insignificant. Five men who suffered blast injury to the ear were examined and followed up. The vestibular evaluation included electronystagmography and the smooth harmonic acceleration test. Acute vestibular symptoms and clinical and laboratory signs were found in three patients. These resolved along with the clinical improvement. Despite the evident vestibular compensation, permanent vestibulopathy was diagnosed in two patients. Our observations stress the importance of complete vestibular evaluation in cases of blast injury to the ear, regardless of a perhaps misleading clinical picture. Apart from the medicolegal aspects, such patients should be cautioned regarding the possibility of spatial disorientation during future exposure to unusual environmental conditions. (Arch Otolaryngol Head Neck Surg. 1993;119:1362-1367) | f7f81f95e963d4052ea2bf5067670d52cdaa3ef5 | Unpaywall, MAG, Medline | Environmental Science, Medicine | Medicine | DOI:10.1001/ARCHOTOL.1993.01880240100013, MAG:1982385732 |
4,980,317 | pes2o/s2ag | v3-fos-license | 2018-04-03T00:57:15.951Z | 2004-09-01T00:00:00.000 | Self-assembly of flexible supramolecular metallacyclic ensembles: structures and adsorption properties of their nanoporous crystalline frameworks. | The syntheses, structures, and N2 adsorption properties of six new supramolecular metallacycles are reported. Flexible ditopic linkers, 1-4, with systematically varied lengths and conformational degrees of freedom were synthesized utilizing ester linkages. They were used in combination with (dppp)M(OTf)2, where M = Pt(II) and Pd(II), and cis-(Me3P)2Pt(OTf)2 to form flexible supramolecular metallacycles 5-10 in 88-98% isolated yields. Their structures were characterized via multinuclear NMR and X-ray crystallography. The metallacycles stack to form porous structures in the crystalline state. The pore dimensions depend on both the phosphorus ligands attached to the metals and the flexible linkers. Adsorption studies on the porous materials show that 5a, 6, 8, and 9 held 11.7, 16.5, 5.7, and 6.8 cm3/g STP of N2 at 77 K, respectively. A guest-exchange study with nitromethane and toluene reveals that the nanopore in 5 is flexible, a property which was transferred from the linker to the supramolecular structure in the solid state. | a9045b39614e75233eca477c204c254519179b28 | MAG, Unpaywall, Medline, Anansi, ScienceParseMerged | Chemistry, Materials Science | Chemistry, Medicine | DOI:10.1021/JA0388919, MAG:2101084723 |
267,610,017 | pes2o/s2ag | v3-fos-license | 2024-02-11T16:30:16.255Z | 2024-02-08T00:00:00.000 | Pay disparities in the Federal District Civil Police and the impacts of Law 9264/96 | This article investigates the historical origin of salary disparities in the Civil Police of the Federal District (DF), with an emphasis on the implications of Law 9264/96, which established the requirement for higher education for entry into certain positions. The research employs an exploratory documentary analysis of relevant legislation and administrative records to trace the evolution of salary policies and identify points of failure in their implementation. It was observed that, despite subsequent legislative changes aimed at defining higher-level functions, an ineffective implementation resulted in salary inequalities among similar positions. This salary discrepancy originated from an administrative error in the application of Law 9264/96, maintaining the subsidies for some positions based on the mid-level salary table of Decree Law 2266/85. The article offers a critical analysis of salary policies and their consequences on the structure of the Civil Police of the DF, aiming to document the evolution of this salary difference. The conclusions indicate that such disparity not only contradicts the principles of equity and salary justice but also reflects challenges in administrative adaptation to new legal standards. The study underlines the need for periodic and effective reviews in remuneration structures to align administrative practices with legal requirements and workforce needs. The aim is to provide a historical record that clarifies the reasons for salary disparity, contributing to a deeper understanding of the complexities associated with remuneration in the same career, and suggesting paths for future reforms in human resources management in the Civil Police of the DF. | c2d45813bb4f400c6299a965e65de725f6ee32bc | Crossref | Law, Political Science | null | DOI:10.55905/revconv.17n.2-026 |
143,604,427 | pes2o/s2ag | v3-fos-license | 2019-05-04T13:06:41.034Z | 1999-12-01T00:00:00.000 | The Life Space Questionnaire: A Measure of the Extent of Mobility of Older Adults | Mobility in older adults is typically discussed in terms of component maneuvers including analy sis of gait and postural instability; activities that depend on mobility such as bathing, dressing, or shopping; or adverse events during mobility such as falls or motor vehicle crashes. None of these approaches reflects a key aspect of mobility-the extent of movement within a person's environment, or life space in the gerontological literature. Here we describe this concept as it applies to mobility and present a questionnaire instrument designed to measure life space in community-dwelling older adults. Results indicate that the Life Space Questionnaire (LSQ) is reliable and has construct and criterion validity in a sample of olderadults. The LSQ can be used to establish the spatial extent of an older person's mobility and may ultimately be useful as an outcome measure in studies evaluating interventions designed to enhance mobility and inde pendence in community-dwelling older populations. | 9fb1d652ae08f76aa09a7d8a0239cffb904cfce2 | Sage, MergedPDFExtraction, Unpaywall, MAG | Education | Psychology | DOI:10.1177/073346489901800404, MAG:1998202445 |
36,610,636 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:49:13.700Z | 1996-02-01T00:00:00.000 | Simultaneous extraction of cellular lipids and water‐soluble metabolites: Evaluation by NMR spectroscopy | A method for simultaneous extraction of lipids and water‐soluble metabolites from a single cell sample was developed and optimized for NMR spectroscopy. Intermediary metabolites in cultured M2R mouse melanoma cells and changes therein in response to challenge with melanotropin were studied by 31P and 13C NMR. Cells were extracted with methanol, chloroform, and water (1:1:1, v/v/v). The contents of the chloroform and methanol‐water phases were separated and quantitatively recovered. The contents of the upper and lower phases compared well with the homologous fractions obtained by perchloric acid and Folch's lipid extraction methods. The pH of the extracts remained within the physiologic range, eliminating potential deleterious effect on cellular metabolites. The water phase contained minimal amounts of salts, making these extracts amenable to subsequent analytical procedures. Obtaining lipid‐ and water‐soluble metabolites from the same sample enables characterization of metabolic pathways that bridge the two cellular components in a quantitative manner. | 996ba2084f3b0c0225d7f235669eec15e2479501 | Unpaywall, Wiley, ScienceParsePlus, Medline, MergedPDFExtraction, MAG | Biology, Chemistry, Medicine | Medicine, Chemistry | DOI:10.1002/mrm.1910350210, MAG:2044124957 |
22,671,286 | pes2o/s2ag | v3-fos-license | 2018-04-03T01:36:40.946Z | 2015-02-01T00:00:00.000 | Sliding humeral osteotomy: medium-term objective outcome measures and reduction of complications with a modified technique. | OBJECTIVE
To determine mid-term complication rate associated with a modified sliding humeral osteotomy (SHO) technique and compare clinical outcome with or without focal treatment (FT).
ANIMALS
Dogs (n = 46; 60 elbows) with severe or persistent lameness attributable to medial coronoid disease (MCD).
METHODS
Signalment, lameness, pain score, and preoperative radiographic findings were recorded. Modified Outerbridge score and fissure/fragmentation were recorded arthroscopically. SHO was performed with technical modifications. Outcome measures included lameness score, elbow pain score, owner function assessment, and force-plate preoperatively, at 6 and 12 weeks, and 6-25 months.
RESULTS
SHO was performed on 60 limbs; 22 also had FT of the medial coronoid process. Mean (±SD) dog age was 44.17 ± 33.0 months and weight range was 17.4-49.8 kg. Preoperative duration of lameness was 2.16 ± 0.69 months. Lameness improved for all limbs by 12 weeks, and resolved in 49 limbs. Significant improvements in postoperative pain scores and most owner function assessments occurred. There was no significant difference with or without FT. There were no major complications and 4.17% minor complications. Force-plate data available for 18 of 46 dogs operated unilaterally preoperatively and at last follow-up showed significant improvement in ground reaction force and reduction of asymmetry index (t-test; P < .05).
CONCLUSIONS
SHO with or without focal treatment of the medial aspect of the coronoid process ameliorates lameness and pain associated with MCD at medium-term follow-up. Application technique is critical to minimize morbidity. | d679959abbdd726339ffe0cde4f04f12bf17653f | Medline, Unpaywall, MAG | Medicine | Medicine | DOI:10.1111/j.1532-950X.2014.12213.x, MAG:2968175271 |
18,072,486 | pes2o/s2ag | v3-fos-license | 2017-02-16T00:03:07.572Z | 2014-04-03T00:00:00.000 | A unique design of Photonic Crystal Fibers for negative dispersion and high birefringence | In this paper we propose some new geometries of Photonic Crystal Fiber (PCF). These new geometries are derived from the design of antenna of different geometry . We have used the concept of C-shaped, L-shaped, E-shaped and H-shaped antenna for designing the PCF. At a wavelength of 0.85 μm the C-shaped PCF structure report the most negative dispersion and almost zero otherwise. The birefringence of H-shaped PCF structure is high compare to that of other proposed PCF structure. The confinement Loss reported is of the order of 10-3 for all the proposed PCF structures. The confinement factor was reported to be maximum for all the proposed structures other than proposed C-shaped PCF structure. The far field pattern (FFP) is observed of elliptical shape for H-shaped and L-shaped PCF structure whereas it is of circular shape for C-shaped and E-shaped PCF structure. | 34bc0e60e5b3d3b84b4a1644f48051755e517667 | Grobid, MAG, Unpaywall, ScienceParseMerged, IEEE | Materials Science | Computer Science | DOI:10.1109/ICCSP.2014.6950072, MAG:2111420024 |
17,022,786 | pes2o/s2ag | v3-fos-license | 2016-10-06T01:13:34.721Z | 1998-06-01T00:00:00.000 | Distribution of Dopamine Transporter in the Rat: an Immunohistochemical Study. | OBJECTIVE: To investigate the organ distribution of dopamine transporter (DAT) in rats by immunohistochemical method. METHODS: Dopamine transporter (DAT) was identified immunohistochemically in the tissues using specific antipeptide antiserum raised in New Zealand white rabbits immunized with a conjugate of synthetic DAT peptide (29-45) with bovine serum albumin. Immunohistochemical analysis was performed by avidin-biotin complex method. RESULTS: DAT immunoreactivity was visualized in the neural perikarya, axons and dendrites of the central nervous system, retina, adrenal medulla, Auerbach's nervous branch and Meissner's nervous branch of the stomach, small intestine and colon, anterior pituitary, and lung. When using antiserum preincubated with synthetic DAT peptide (DAT, 29-45) or hypothalamus homogenate which contains DAT, no significant stain of neurons in the hypothalamus was detected. CONCLUSION: These findings suggest that DAT is widely distributed and that the method used is valuable in studying the distribution of DAT in rats. | e7814ea18ce0f5d92bbd36bedefa60b276385da3 | Medline, Grobid, Anansi, ScienceParseMerged, MAG, Crawler | Biology, Medicine | Biology, Medicine | MAG:1590215417 |
259,895,286 | pes2o/s2ag | v3-fos-license | 2023-07-15T15:07:08.353Z | 2023-07-12T00:00:00.000 | Tourism, Value Appropriation, and Ecological Degradation | This article highlights the main characteristics of the rapid development of tourism during recent decades, as well as the limitations of the existing literature concerning this development. An alternative (Marxist) theoretical framework is then developed for the explication of the development of commodified tourism, the role of ecological and cultural (value) appropriation in the determination of capitalist profitability, and its developmental implications. As argued, this value and resource appropriation and the exploitation/appropriation dialectic have adverse socioeconomic and ecological implications, while leading to the rapid growth of tourism against other sectors. On the other hand, the cultural homogenization and ecological degradation brought about especially by mass tourism imply a self-limiting development of tourism itself. Concluding that the current mode of tourism development is ecologically and socially unsustainable, we end with a broad outline of a different perspective of decommodified tourism within a post-capitalist development. | bd737a58b920d1409aaa8fcd260d189e3e69e9e5 | Crossref | Environmental Science, Economics, Philosophy | null | DOI:10.3390/tourhosp4030025 |
234,960,045 | pes2o/s2ag | v3-fos-license | 2021-05-22T00:02:50.899Z | 2021-01-01T00:00:00.000 | Analysis of Scoring System to Identify High Risk Patients and their Outcome in Isolated Blunt Chest Trauma- A Prospective Observational Study | Introduction: Chest trauma is a major cause of mortality accounting for a substantial proportion of all trauma admissions and death. In India, the reported mortality range is between 4-60% and no current national guidelines exist to assist the management of this patient group unless patient has severe immediate life threatening injuries. A scoring system for identification of patients at higher risk for development of morbidity and mortality will allow early selection of vulnerable patients, choice of an appropriate treatment protocol and therapeutic interventions. Aim: This present study aims for the analysis of a scoring system to identify patients with isolated blunt chest trauma at higher risk for morbidity and mortality, in order to prioritise intervention and improve the outcome. Materials and Methods: This was a prospective observational study conducted at the departments of emergency medicine and general surgery of a tertiary care teaching hospital in South India over a period of 18 months. The study included 85 isolated blunt chest trauma patients. We utilised a Chest Trauma Score (CTS) composed of patient factors like age, smoking, lung disease and severity factors like rib fractures, parenchymal and pleural involvement, partial pressure of oxygen/ fraction of inspired oxygen (PaO2/FiO2) ratio. CTS were applied at the time of admission after detailed assessment of all injuries. Patient was followed-up at regular intervals upto 30 days. The CTS and outcome measurements were analysed using logistic regression analysis. Results: The area under Receiver Operating Characteristic curve (ROC) was found to be 0.979 (p-value <0.001). The CTS cut-off value was ≥11.5 with 89% sensitivity and 95% specificity. In patients with CTS ≥11.5, 98.3% had associated morbidity and complications whereas only 25.9% with CTS <11.5 had associated morbidity (p-value<0.001). Number of rib fractures, pulmonary contusion and PaO2/FiO2 ratio (odds ratio 10.632, 6.007, 12.859, respectively) were found to be significant independent predictors of morbidity and complications. Conclusion: In summary, CTS ≥11.5 has shown a significant association with poor outcome. Patients who sustained isolated blunt chest trauma and together with increasing scores, had increasing incidence of morbidity and complications. The scoring system used in this study proved that it makes a useful tool to predict the outcome in thoracic trauma. | 826e209b5bcedc1599ba6c01f01852d3721a78ad | MAG, Crossref | Medicine | Medicine | DOI:10.7860/JCDR/2021/46682.14749, MAG:3154316296 |
25,710,327 | pes2o/s2ag | v3-fos-license | 2018-04-03T05:44:11.701Z | 2011-06-01T00:00:00.000 | [The relationship of empathic-affective responses toward others' positive affect with prosocial behaviors and aggressive behaviors]. | The purposes of this study were to develop and validate the Empathic-Affective Response Scale, and to examine the relationship of empathic-affective responses with prosocial behaviors and aggressive behaviors. Undergraduate students (N = 443) participated in a questionnaire study. The results of factor analysis indicated that empathic-affective responses involved three factors: (a) sharing and good feeling toward others' positive affect, (b) sharing of negative affect and (c) sympathy toward others' negative affect. Correlations with other empathy-related scales and internal consistency suggested that this scale has satisfactory validity and reliability. Cluster analysis revealed that participants were clustered into four groups: high-empathic group, low-empathic group, insufficient positive affective response group and insufficient negative affective response group. Additional analysis showed the frequency of prosocial behaviors in high-empathic group was highest in all groups. On the other hand, the frequency of aggressive behaviors in both insufficient positive affective response group and low-empathic group were higher than others' groups. The results indicated that empathic-affective responses toward positive affect are also very important to predict prosocial behaviors and aggressive behaviors. | 595baa38d18b79727736d15689750fda49672fe5 | Unpaywall, Medline, Anansi, MAG, ScienceParseMerged | Psychology | Psychology, Medicine | DOI:10.4992/JJPSY.82.123, MAG:1989742925 |
5,028,827 | pes2o/s2ag | v3-fos-license | 2018-04-23T20:43:50.096Z | 2003-03-01T00:00:00.000 | Role of acetylcholine on plant root-shoot signal transduction | The role of acetylcholine (ACh) on plant rootshoot communication was investigated using the root-split system of Vicia faba L. In the experiments, slight osmotic stress caused the decrease of ACh content in root tips and the xylem sap transported up per time unit from root tip to the shoot when the water potential of the shoot was kept unchanged. It also caused the decrease of ACh content in the abaxial epidermis. The decrease was highly correlative to the changes of transpiration rate, suggesting that the decrease of ACh content probably functions as a signal to regulate stomatal behavior. The effect of osmotic stress might be mainly through the inhibition of the ACh synthesis in root tip; thus further influences the ACh content in root tip, xylem sap and abaxial epidermis and resulting in the changes of stomatal behavior. These results provide new evidence that plants transduce positive and negative signals among roots and shoots to coordinate stomatal behavior and adapt to variable environments. | ab0774de7c59359a264b01be9021687d56df94b5 | SpringerNature, MAG, Anansi, ScienceParseMerged, Unpaywall | Biology, Environmental Science | Biology | DOI:10.1360/03TB9121, MAG:1991785816 |
120,788,277 | pes2o/s2ag | v3-fos-license | 2019-04-18T13:04:54.869Z | 2005-04-01T00:00:00.000 | Time series AR(1) model for short-tailed distributions | The innovations in AR(1) models in time series have primarily been assumed to have a normal or long-tailed distributions. We consider short-tailed distributions (kurtosis less than 3) and derive modified maximum likelihood (MML) estimators. We show that the MML estimator of φ is considerably more efficient than the commonly used least squares estimator and is also robust. This paper is essentially the first to achieve robustness to inliers and to various forms of short-tailedness in time series analysis. | 2b40012f7f57a3862c8f77fb4aea551b585c1527 | MAG, Unpaywall, TaylorAndFrancis, MergedPDFExtraction | Mathematics, Economics | Mathematics | DOI:10.1080/02331880512331344036, MAG:1964688055 |
86,479,827 | pes2o/s2ag | v3-fos-license | 2019-03-28T13:33:06.924Z | 2019-01-24T00:00:00.000 | Co-Infection with Nocardia and Mycobacterium avium complex (MAC) in a patient with acquired immunodeficiency syndrome | We present a case in which a patient with acquired immunodeficiency syndrome (AIDS) and nocardiosis was found to have co-infection with Mycobacterium avium complex (MAC). Despite the fact that MAC is a known colonizer of the pulmonary system, it is possible to have co-infection and a high degree of suspicion is necessary to ensure prompt treatment of both organisms. We wish to describe how radiologic findings were instrumental in guiding our differential diagnosis. | 63b73b1b52d1ce266bc7af012f8c6eb7a7b42950 | ScienceParseMerged, Unpaywall, Crossref, Anansi, MAG | Medicine | Medicine | DOI:10.13175/SWJPCC123-18, MAG:2912032858 |
7,140,823 | pes2o/s2ag | v3-fos-license | 2018-01-23T22:43:16.985Z | 1996-01-03T00:00:00.000 | Does retiming affect redundancy in sequential circuits? | Retiming is used to optimize logic and improve the speed of operation in sequential circuits keeping the circuit behavior unchanged. In this paper, we show with various examples that retiming affects redundancy of faults. It may change an operationally redundant fault to a partially one, and a combinationally redundant fault to an irredundant but sequentially untestable fault. Many novel transformations of combinational redundancy to sequential redundancies are also exemplified. Thus, retiming strongly influences test generation and design for testability techniques in sequential circuits. | 3e6b28cf0287a7d73f9af7c476a5fe0113e6f379 | Unpaywall, IEEE, MAG, ScienceParseMerged, DBLP | Engineering | Computer Science | DOI:10.1109/ICVD.1996.489607, MAG:2126468650 |
235,508,773 | pes2o/s2ag | v3-fos-license | 2021-06-22T17:55:23.640Z | 2021-04-29T00:00:00.000 | A Survey of Normalization Methods in Multiobjective Evolutionary Algorithms | A real-world multiobjective optimization problem (MOP) usually has differently scaled objectives. Objective space normalization has been widely used in multiobjective optimization evolutionary algorithms (MOEAs). Without objective space normalization, most of the MOEAs may fail to obtain uniformly distributed and well-converged solutions on MOPs with differently scaled objectives. Objective space normalization requires information on the Pareto front (PF) range, which can be acquired from the ideal and nadir points. Since the ideal and nadir points of a real-world MOP are usually not known a priori, many recently proposed MOEAs tend to estimate and update the two points adaptively during the evolutionary process. Different methods to estimate ideal and nadir points have been proposed in the literature. Due to inaccurate estimation of the two points (i.e., inaccurate estimation of the PF range), objective space normalization may deteriorate the performance of an MOEA. Different methods have also been proposed to alleviate the negative effects of inaccurate estimation. This article presents a comprehensive survey of objective space normalization methods, including ideal point estimation methods, nadir point estimation methods, and different methods based on the utilization of the estimated PF range. | bb99f02713732a182b2f7d679a354c01ae6d3e5f | Crossref, DBLP, IEEE, MAG | Mathematics | Computer Science | DOI:10.1109/TEVC.2021.3076514, MAG:3158941987 |
250,939,823 | pes2o/s2ag | v3-fos-license | 2022-07-22T15:15:44.909Z | 2022-05-04T00:00:00.000 | Decentralized Robust Control for Internet of Connected Vehicles against Cyber-attacks | This paper investigates the problem of heterogeneous internet of connected vehicles (IOCV) with cyber-attacks. An IOCV model is established, in which the cyber-attacks is involved. Then a novel decentralized control design method is proposed based on the robust observer and the sliding mode technique. In addition, the stability conditions are derived by using Lyapunov method, and the stability conditions in the form of linear matrix inequality (LMI) of the observer and controller are strictly deduced to ensure the stability of the connected vehicle system. The simulation results also verify the effectiveness of the proposed method. | b62aba39cac77cc6ef5d76c6cb5c08804316dec6 | IEEE, Crossref, DBLP | Engineering, Mathematics | Computer Science | DOI:10.23919/ascc56756.2022.9828199 |
13,535,323 | pes2o/s2ag | v3-fos-license | 2018-04-03T00:36:14.488Z | 2002-12-01T00:00:00.000 | Rotational vertebral artery occlusion from occipital bone anomaly: a rare cause of embolic stroke. Case report. | Vertebral artery (VA) occlusion by rotation of the head is uncommon, but can result from mechanical compression of the artery, trauma, or atlantoaxial instability. Occipital bone anomalies rarely cause rotational VA occlusion, and patients with nontraumatic intermittent occlusion of the VA usually present with compromised vertebrobasilar flow. A 34-year-old man suffered three embolic strokes in the vertebrobasilar system within 2 months. Magnetic resonance imaging demonstrated multiple infarcts in the vertebrobasilar territory. Angiography performed immediately after the third attack displayed an embolus in the right posterior cerebral artery. Radiographic and three-dimensional computerized tomography bone images exhibited an anomalous osseous process of the occipital bone projecting to the posterior arch of the atlas. Dynamic angiography indicated complete occlusion of the left VA between the osseous process and the posterior arch while the patient's head was turned to the right. Surgical decompression of the VA resulted in complete resolution of rotational occlusion of the artery. An occipital bone anomaly can cause rotational VA occlusion at the craniovertebral junction in patients who present with repeated embolic strokes resulting from injury to the arterial wall. | 51af6ecc7522c193ffe3394a79382ec5c1c5f35e | Unpaywall, Anansi, MAG, Medline, ScienceParseMerged | Medicine | Medicine | DOI:10.3171/JNS.2002.97.6.1456, MAG:2005743308 |
39,239,758 | pes2o/s2ag | v3-fos-license | 2018-04-03T04:30:05.759Z | 1996-07-24T00:00:00.000 | Death certificate completion by physicians. | To the Editor. —Drs Messite and Stellman 1 conclude that training in death certificate completion should be part of physician training but usually is not. Similar to their pilot study results, a recent survey of 198 physician medical examiners showed that only 13% received death certificate training in medical school and only 29% received such training during residency (National Association of Medical Examiners interim meeting, Nashville, Tenn, February 1996). However, training should probably include the targeting of selected groups of physicians because many physicians sign few or no death certificates. 2 The following suggestions include acrossthe-board and targeted educational measures. 1. The Association of American Medical Colleges could recommend that all medical schools provide students with (or require students to obtain) readily available instruction manuals on death certification. 3,4 2. The United States Medical Licensure Examination and other medical school examinations could routinely include questions on death certification. 3. The Accreditation Council on Graduate | 5eb8dd2a33209ae52e9728d38a21877793938691 | MAG, Unpaywall, Medline | Medicine | Medicine | DOI:10.1001/JAMA.1996.03540040023013, MAG:2019974169 |
699,008 | pes2o/s2ag | v3-fos-license | 2017-02-11T22:20:43.583Z | 2008-10-01T00:00:00.000 | An Improved Nodes Localization Scheme with Energy Saving Flooding Base on MAS in WSN | Wireless sensor networks (WSN) have become possible because of the on-going improvements in sensor technology. Sensor nodes localization is a new important research point. Getting the smallest location error and the least energy wasted in nodes localization is the final goal. Many work in literature proposed schemes and methods for localization in wireless sensor networks. In this paper we present a localization approach with dewdrop-flooding mechanism base on multi-agent system method, which can make location errors decrease and saving energy in evidence. | 883ae15a1d3eeae093d48e3afded676fd5f15cdc | IEEE, Unpaywall, ScienceParseMerged, MAG, Grobid | Computer Science, Engineering, Environmental Science | Computer Science | DOI:10.1109/WICOM.2008.840, MAG:2111243638 |
96,210,580 | pes2o/s2ag | v3-fos-license | 2019-04-05T03:35:09.856Z | 2013-03-20T00:00:00.000 | Understanding the Mechanism of Solvent‐Mediated Adhesion of Vacuum Deposited Au and Pt Thin Films onto PMMA Substrates | The adhesion of vapor deposited Au and Pt thin films onto poly(methyl methacrylate) (PMMA) substrates can be significantly enhanced by either spin‐casting or vapor‐exposure to hydrohalocarbon solvents prior to metal deposition. X‐ray photoelectron spectroscopy (XPS) and evolved gas analysis Fourier transform infrared spectroscopy detect residual halogenated solvent at the PMMA surface which chemically activates the surface. Density functional theory (DFT) calculations show that the solvent molecules form a Lewis acid‐base adduct with the ester oxygens in PMMA. DFT predicts that the deposited metal atom (M) inserts into the C–halogen (X) bond on either CHCl3 or CHBr3 to form a O–M–X interaction. This is consistent with M–X bonding observed in high resolution XPS. A model is proposed in which the bond energy of the C–X bond of the solvent must be weak enough so that it can be cleaved by the metal atom to form a M–X bond. A negative control of PMMA exposed to CHF3 is shown to have no effect on Au or Pt adhesion since the bond dissociation energy of the C–F bond is stronger than the C–Cl and C–Br bond energy compared to the metal halide bond energies. | 49118f3a59d5baed50299ca67ec8b3fe4510b27c | Wiley, MergedPDFExtraction, Unpaywall, MAG | Chemistry, Materials Science | Materials Science | DOI:10.1002/adfm.201201955, MAG:2024293473 |
244,886,258 | pes2o/s2ag | v3-fos-license | 2021-12-05T16:05:54.155Z | 2021-12-01T00:00:00.000 | EVALUATION OF ATRIAL FIBRILLATION BURDEN AFTER THE FIRST ECG-DOCUMENTED EPISODE VIA IMPLANTABLE LOOP RECORDERS | Objective: The natural history of paroxysmal atrial fibrillation (AF) after the first clinical AF episode is not well known. AF burden is of clinical significance as it may have clinical implications concerning the long-term management of the arrhythmia and the decision-making on AF patients. We studied the natural history of AF in patients after their first clinical AF episode. Design and method: Thirty consecutive patients (age 66.9 ± 10 years; 14 men) received an implantable loop recorder (ILR) (Reveal XT 9529; Medtronic, Minneapolis, Minnesota, USA) after their first symptomatic paroxysmal AF episode. We recorded the AF recurrences and burden (clinical and subclinical AF) during a follow-up period of three years. We excluded patients with persistent or permanent AF and patients with AF attributed to reversible or transient causes. Results: Eight patients (26.6%) did not present any AF recurrence during the first year of the follow-up period. Five patients (16.6%) did not also suffer any AF episode during the second year, while in three patients (10%) no AF episode was recorded during the three-year follow-up period. In 16 patients (53.3%) the AF burden was increased during the second year of follow-up period while in 9 patients (30%) the AF burden was decreased. During the third year of follow-up period the AF burden was increased in 19 patients (63.3%), decreased in 7 patients (23.3%) and remained almost the same in 4 patients (13.3%). Five patients (16.6%) presented at least one episode of persistent AF during the follow-up period. Seven patients (23.3%) suffered only from symptomatic AF episodes, while in nine patients (30%) only asymptomatic AF episodes were recorded. Eleven patients (36.7%) had both types of AF episodes (symptomatic and asymptomatic). Conclusions: The AF recurrences and burden increased in most AF patients during the three-year follow-up period. However, some patients did not suffer any AF recurrence or they presented a decrease in AF burden. Paroxysmal AF clinical profile differs among the AF patients significantly and this indicates that an individualized approach via long-term rhythm monitoring may be of clinical significance, at least in some newly diagnosed AF patients. | 685c09ce2d0194b4f3c74fdde0afd161a09a831f | WoltersKluwer, Crossref, Medline, MergedPDFExtraction, Anansi, ScienceParsePlus | Medicine | Medicine | DOI:10.1097/01.hjh.0000835876.04121.f2 |
963,558 | pes2o/s2ag | v3-fos-license | 2015-12-23T19:26:37.933Z | 2012-10-08T00:00:00.000 | GSFord: Towards a Reliable Geo-social Notification System | The eventual goal of any notification system is to deliver appropriate messages to all relevant recipients with very high reliability in a timely manner. In particular, we focus on notification in extreme situations (e.g. disasters) where geographically correlated failures hinder the ability to reach recipients inside the corresponding failed region. In this paper, we present GSFord, a reliable geo-social notification system that is aware of (a) the geographies in which the message needs to be disseminated and (b) the social network characteristics of the intended recipient, in order to maximize/increase the coverage and reliability. GSFord builds robust geo-aware P2P overlays to provide efficient location-based message delivery and reliable storage of geo-social information of recipients. When an event occurs, GSFord is able to efficiently deliver the message to recipients who are either (a) located in the event area or (b) socially correlated to the event (e.g. relatives/friends of those who are impacted by an event). Furthermore, GSFord leverages the geo-social information to trigger a social diffusion process, which operates through out-of band channels such as phone calls and human contacts, in order to reach recipients which are isolated in the failed region. Through extensive evaluations, we show that GSFord is reliable, the social diffusion process enhanced by GSFord reaches up to 99.9\% of desired recipients even under massive geographically correlated regional failures. We also show that GSFord is efficient even under skewed distribution of user populations. | deb631fd71dab01abb5217fa7da6213889ddb21b | Anansi, Grobid, Unpaywall, DBLP, IEEE, MAG, Crawler, ScienceParseMerged | Computer Science, Geography | Computer Science | DOI:10.1109/SRDS.2012.35, MAG:2055312243 |
17,708,758 | pes2o/s2ag | v3-fos-license | 2016-05-21T08:49:11.215Z | 2011-12-01T00:00:00.000 | Human Capital Risk, Contract Enforcement, and the Macroeconomy | We use data from the Survey of Consumer Finance and Survey of Income Program Participation to show that young households with children are under-insured against the risk that an adult member of the household dies. We develop a tractable macroeconomic model with human capital risk, age-dependent returns to human capital investment, and endogenous borrowing constraints due to the limited pledgeability of human capital (limited contract enforcement). We show analytically that, consistent with the life insurance data, in equilibrium young households are borrowing constrained and under-insured against human capital risk. A calibrated version of the model can quantitatively account for the life-cycle variation of life-insurance holdings, financial wealth, earnings, and consumption inequality observed in the US data. Our analysis implies that a reform that makes consumer bankruptcy more costly, like the Bankruptcy Abuse Prevention and Consumer Protection Act of 2005, leads to a substantial increase in the volume of both credit and insurance. | 47bae731f64bcd0babc089ae7f3499658c9d4ce0 | ScienceParseMerged, ElsevierPush, MergedPDFExtraction, Crawler, Anansi, Crossref, Grobid, Unpaywall, MAG | Economics | Economics | DOI:10.2139/SSRN.2526293, MAG:2119141349 |
210,917,450 | pes2o/s2ag | v3-fos-license | 2020-01-02T21:10:51.477Z | 2019-01-01T00:00:00.000 | The importance of sports education in the primary school: An experimental pedagogical project | The educational role of sport in the various socio-relational contexts is now an internationally consolidated reality; however, in the Italian school context, especially at primary level, sports activity still does not have the possibility to express all its pedagogical potential. In this regard, this research work aims at proving the ability to develop indispensable skills for a complete growth of children, through a pedagogical experimental project in the field of motor-sports education at school level. This research work involves a heterogeneous class of a primary school, and was carried out within a limited period of time during school hours. Its outcomes confirm the basic hypothesis, and are proposed as a solid basis for future studies in experimental pedagogy applied to the field of motor and sports sciences. | 1c86b93e7f2d7c3258099c9c53e70f9c91afc198 | MAG, Anansi, Unpaywall, Crossref, MergedPDFExtraction | Education | Psychology | DOI:10.14198/jhse.2019.14.proc5.10, MAG:2995054251 |
43,680,700 | pes2o/s2ag | v3-fos-license | 2018-01-24T17:25:33.048Z | 2016-05-01T00:00:00.000 | Squat Assessment following a Postural Correction Intervention: 405 Board #242 June 1, 11: 00 AM - 12: 30 PM. | The back squat (BaSq) is an exercise that has been shown to be very effective in improving athletic performance. As such, the BaSq should be a primary focus of any strength and conditioning program. However, performance of the BaSq with poor technique under load is a potentially harmful scenario. Therefore, it is important for athletes to learn and for coaches to screen for proper posture and technique during the BaSq exercise. PURPOSE: To introduce a protocol for assessing squat technique and determine the effectiveness of a postural correction program. METHODS: A total of four female collegiate student-athletes (age: 17.8 ± 0.5 yrs; height: 156.8 ± 8.3 cm; mass: 53.4 ± 4.9 kg) were assessed at baseline during the offseason, and then 12 weeks after having gone through a postural correction program. The postural correction program consisted of mobility exercises focused on avoiding postural asymmetries and maintaining a neutral spine and a neutral subtalar joint. Three-dimensional motion capture and two force plates were used to record the kinematics and kinetics of two body-weight squats. Peak joint angles and power absorption and generation were calculated bilaterally for ankle, knee, and hip, and inter-limb difference was calculated. Squat depth was calculated from the sacrum marker as a percentage of standing height. Pre and post comparisons were made using multiple separate t-tests. RESULTS: Ankle range of motion significantly improved for both limbs (left: 24.9±6.8° vs. 30.3±5.1°; right: 25.9±5.8° vs. 29.3±5.8°, p<0.05). However, range of motion decreased in the left knee (125.4±18.0° vs. 121.2±17.5°, p<0.05), and in both hips (left: 112.0±94.4° vs. 94.4±9.2°; right: 110.8±94.4° vs. 95.8±7.9°, p<0.05). There were no significant changes in any other variable. CONCLUSIONS: The proposed analysis may prove to be an effective method of evaluating lower extremity range of motion. Following the experimental postural correction program, the athletes showed improve range of motion at the ankle, but decreased range of motion at the knee and hip leading to no change in overall squat depth. Further investigations should consider a larger experimental group and non-athletic population. | 88e83b9710c57589d3bf568a0120c80dfe50e7a5 | WoltersKluwer, MergedPDFExtraction, MAG, Unpaywall, Medline | Medicine | Medicine | DOI:10.1249/01.mss.0000485336.45640.ac, MAG:2517029482 |
24,905,496 | pes2o/s2ag | v3-fos-license | 2018-04-03T02:29:17.995Z | 2008-12-01T00:00:00.000 | Molecular identity of a pan cancer marker, CA215 | The molecular nature of cancer-associated antigen, CA215 which reacts with RP215 monoclonal antibody and its unique epitope(s) was characterized. RP215 was initially selected and produced from one of 3,000 hybridomas which were generated from mice immunized with the cell extract of OC-3-VGH ovarian cancer cells. This cancer-associated antigen from various sources including cancer cell extract, shed culture medium and affinity-purified forms was analyzed by MALDI-TOF MS (Matrix Adsorption Laser Desorption Ionization-Time of Flight Mass Spectrometry), Western blot, carbohydrate profiling as well as enzyme immunoassays. The results of this study showed that CA215 is homologous to the heavy chains of human immunoglobulins with molecular sizes ranging from 50 to 70 KDa, when probed with RP215 or anti-human immunoglobulin G, A or M. Treatments of cancer cells with NaIO4 drastically reduce RP215 binding to the carbohydrate-associated epitope(s) of CA215 located on the variable domain of the human immunoglobulin heavy chains. Further studies indicated that CA215 is predominantly expressed by cancer cells in both secreted and membrane-bound monomeric forms. The carbohydrate-associated epitope(s) with pH-sensitive immunoactivity appear to be present only in cancer cell-derived immunoglobulins, but not in normal human immunoglobulins. Compared to normal immunoglobulin G, CA215 contains a significantly higher percentage of N-acetyl and N-glycoyl neuraminic acid (28% vs. 8%) in the O-linked glycans, but a lower content of N-acetylglucosamine (28% vs. 41%) in the N-linked ones. It was concluded from this study that RP215 reacts specifically with carbohydrate-associated epitope(s) of immunoglobulin heavy chains expressed by various human cancer cells. | ab23e76673a9a75613a26097777abe42f20bf6fb | Medline, TaylorAndFrancis, MergedPDFExtraction, MAG, Unpaywall | Biology | Biology, Medicine | DOI:10.4161/cbt.7.12.6984, MAG:2015971779 |
21,158,546 | pes2o/s2ag | v3-fos-license | 2018-01-23T22:41:48.522Z | 2013-04-01T00:00:00.000 | Achieving Lean Objectives through RFID: A Simulation-Based Assessment | Lean concepts in manufacturing have focused on elimination of wastes within the business processes. This study investigates whether addition of radio frequency identification (RFID) technologies in the manufacturing process can complement Lean manufacturing. Specifically, will more accurate information from RFID-based solutions help achieve the goals of Lean initiatives in manufacturing plant performance and, if yes, in what specific ways? The analysis is based on a comparison of the following three automatic identification technologies: existing (one-dimensional) 1D barcode, 2D barcode, and the use of RFID in a real job-shop environment where items are manufactured for meeting actual demand and also future forecast demand. We analyze the effect of information visibility in these settings by examining the various types of wastes that are typically addressed in Lean initiatives. The results of a discrete-event simulation suggest that employing RFID in Lean manufacturing initiatives can reduce some wastes but not necessarily all types of waste. We observe an increase in overproduction waste in our setting, although other wastes are reduced with improved information visibility. Overall, our results indicate that manufacturing organizations should explore information visibility through RFID to enhance their Lean initiatives. | 23a75f92d557e6022f02715785ea9d6e976d27d0 | DBLP, Unpaywall, ScienceParseMerged, MergedPDFExtraction, MAG, ScienceParsePlus | Business, Computer Science, Engineering | Computer Science | DOI:10.1111/deci.12007, MAG:1551942617 |
1,831,275 | pes2o/s2ag | v3-fos-license | 2014-10-01T00:00:00.000Z | 1999-01-22T00:00:00.000 | A high level of CCAAT-enhancer binding protein-delta expression is a major determinant for markedly elevated differential gene expression of the platelet-derived growth factor-alpha receptor in vascular smooth muscle cells of genetically hypertensive rats. | -Platelet-derived growth factor-alpha receptor (PDGF-alphaR) expression is markedly elevated in cultured vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) when compared with normotensive rat strains, Sprague-Dawley, Wistar, and Wistar-Kyoto rats (WKY). This "almost-all-or-none" type of differential expression strongly suggests that PDGF-alphaR or its transcription-regulating mechanisms or factors are significantly related to genetic hypertension. To evaluate the role of PDGF-alphaR in vascular remodeling and hypertension, we have investigated the underlying molecular mechanism. We have recently shown that the regulatory domain responsible for this difference is localized to the PDGF-alphaR promoter region between -246 and -139, which contains an enhancer core sequence specific for CCAAT-enhancer binding proteins (C/EBPs). We defined the roles of this element for hypertensive strain-specific PDGF-alphaR gene transcription. DNA-protein binding studies by competition in electromobility shift and supershift assays revealed that 2 members, C/EBP-beta and C/EBP-delta, are mainly responsible for DNA-protein complex formation; the former acts as a transcriptional repressor and the latter as an activator of the PDGF-alphaR gene, respectively. Western or Northern blot analyses supported evidence for high expression of C/EBP-delta seen only in SHR-derived VSMCs. Furthermore, forced expression of C/EBP-delta transactivated the transcriptional efficiency of the PDGF-alphaR gene even in WKY-derived VSMCs, whereas that of C/EBP-beta had an opposite effect in SHR-derived VSMCs. These findings indicate that differential expression of members of the C/EBP family, mainly C/EBP-delta and possibly C/EBP-beta, are responsible for the strain-specific gene transcription of PDGF-alphaR in VSMCs. | 77d357b51762eeaa2d2b1c0a6c36552a767b626b | Anansi, ScienceParseMerged, Medline, Grobid, CiteSeerX, MAG, MergedPDFExtraction, Unpaywall, Adhoc | Biology | Medicine, Biology | DOI:10.1161/01.RES.84.1.64, MAG:2170361601 |
3,543,485 | pes2o/s2ag | v3-fos-license | 2018-04-03T05:09:08.920Z | 2018-01-26T00:00:00.000 | Magnesium in Chronic Kidney Disease: Should We Care? | Background: Magnesium (Mg) is an essential cation for multiple processes in the body. The kidney plays a major role in regulating the Mg balance. In a healthy individual, total-body Mg content is kept constant by interactions among intestine, bones and the kidneys. Summary: In case of chronic kidney disease (CKD), renal regulatory mechanisms may be insufficient to balance intestinal Mg absorption. Usually Mg remains normal; however, when glomerular filtration rate declines, changes in serum Mg are observed. Patients with end-stage renal disease on dialysis are largely dependent on the dialysate Mg concentration for maintaining serum Mg and Mg homeostasis. A low Mg is associated with several complications such as hypertension, and vascular calcification, and also associated with an increased risk for both cardiovascular disease (CVD) and non-CVD mortality. Severe hypermagnesaemia is known to cause cardiac conduction defects, neuromuscular effects and muscle weakness; a slightly elevated Mg has been suggested to be beneficial in patients with end-stage renal disease. Key Messages: The role of both low and high Mg, in general, but especially in relation to CKD and dialysis patients is discussed. | eb7ac03c755622d0b4e498742d6327e5cf9054f9 | Medline, Anansi, Karger, Unpaywall, ScienceParseMerged, MergedPDFExtraction, MAG | Medicine, Biology | Medicine | DOI:10.1159/000485212, MAG:2792669568 |
82,156,285 | pes2o/s2ag | v3-fos-license | 2019-03-19T13:13:07.865Z | 1992-10-01T00:00:00.000 | Co‐Expression of Cytokeratins and Vimentin in Sheep Cumulus‐Oocyte Complexes. Alteration of Intermediate Filament Distribution by Acrylamide | The association between germ cells and somatic granulosa cells persists throughout the growth of the oocyte by means of foot processes of the cumulus corona cells that cross the zona pellucida. During meiotic maturation important nuclear and cytoplasmic events occur in cumulus‐oocyte complex suggesting implication of cytoskeletal elements. Immunoblotting analysis of cytoskeletal proteins of the cumulus cells revealed the presence of vimentin polypeptide and of at least two cytokeratin polypeptides. Using immunofluorescence techniques on cryostat sections through frozen tissue, we provided evidence for the presence of cytokeratins of the simple epithelial type in addition to vimentin in sheep cumulus cells. These two types of intermediate filaments were localized throughout the cytoplasm and especially in the foot processes which cross the zona pellucida. The contact area between the two cell types was also labelled with the antibodies. Acrylamide treatment of cumulus‐oocyte complexes involved a drastic disorganization of the intermediate filament network and triggered the isolation of the oocyte from its cumulus cells. This isolation resulted in resumption of meiosis. From these results it appears that intermediate filaments could participate in the process of gap junction loss and indirectly in the control of meiosis resumption. | 5e3d302133fba2ec54ff54f1f60b5a9dc9a32b50 | Wiley, MAG, Medline, Unpaywall, MergedPDFExtraction | Biology | Biology | DOI:10.1111/j.1440-169X.1992.00579.x, MAG:1531342279 |
18,798,815 | pes2o/s2ag | v3-fos-license | 2017-02-18T23:39:47.133Z | 2016-03-16T00:00:00.000 | Geometrical, profile and HOG feature based recognition of Meetei Mayek characters | Recognizaton of Handwritten characters is a challenging task in the computer vision field. However, if can be done with good accuracy will be very much useful for digitizing various documents. Researchers have made various investigations for developing optical character recognition system. The accuracy of the system highly depends upon the features and classifier used. A lot of work is carried out at International level, in India also lot of work is reported in major regional scripts; Devanagri, Bangla, Gurumukhi are few of them. However, it has been observed that only few researchers have considered working on North East Indian regional scripts. As the scripts vary from one another a lot, the feature working well for one script may not be suitable for another one. Our main focus is to develop an OCR system which can work well for Meetei Mayek script. For recognition of handwritten Meetei Mayek isolated characters, we have considered Geometrical and Histogram oriented gradient feature and profile features, which are used as input to the classifier. Recognition accuracy is calculated for SVM and a comparative study is carried out. | 2b4b4b2e2633b0870a163a21939559b2acf9b5ea | ScienceParseMerged, Grobid, MAG, IEEE | Computer Science | Computer Science | MAG:2548097217 |
12,369,499 | pes2o/s2ag | v3-fos-license | 2017-10-24T10:55:07.180Z | 2017-01-02T00:00:00.000 | Response to comment on “Chemosignalling effects of human tears revisited: Does exposure to female tears decrease males’ perception of female sexual attractiveness?” | Response to comment on “Chemosignalling effects of human tears revisited: Does exposure to female tears decrease males’ perception of female sexual attractiveness?” Asmir Gračanin, Ad J. J. M. Vingerhoets and Marcel A. L. M. van Assen Department of Medical & Clinical Psychology, Tilburg University, Tilburg, The Netherlands; Tilburg Center for Cognition and Communication, Tilburg University, Tilburg, The Netherlands; Department of Psychology, University of Rijeka, Rijeka, Croatia; Department of Methodology & Statistics, Tilburg University, Tilburg, The Netherlands; Department of Sociology, Utrecht University, Utrecht, The Netherlands | 60489ed1da1197e8e32732ab5796b81b3b5cfdc6 | Medline, MAG, Unpaywall, ScienceParsePlus, Adhoc, MergedPDFExtraction, Anansi, TaylorAndFrancis, ScienceParseMerged | Psychology | Psychology, Medicine | DOI:10.1080/02699931.2016.1182471, MAG:2395017081 |
266,593,149 | pes2o/s2ag | v3-fos-license | 2023-12-29T16:21:26.925Z | 2023-12-05T00:00:00.000 | Impact of Integrated Training Program on Behavioural Outcome of Adolescents regarding Lifestyle Pattern from selected schools of Mysuru City | Background: Adolescents are independent and they build new relationships, create social skills and learn new habits and practices that they can carry with them for rest of their lives. Adolescent health and wellbeing are influenced by school environment and they must be provided special consideration and emphasis because of their health conditions and needs. A positive lifestyle can bring health and happiness, while a negative life-style can lead to illness and depression. A lifestyle has different components which includes: nutrition, physical activity, sleep pattern, healthy habits, hygienic practices, safety and health awareness, and these components contribute to an individual`s health. Health requires the promotion of healthy lifestyle. Health risk behaviours such as smoking, alcohol abuse, unhealthy dietary patterns, sedentary habits, and unsafe and aggressive behaviours have been found to have an important influence on morbidity and mortality. Health risk behaviours, which develop over time, can also contribute to an unhealthy lifestyle. Adolescent population and health of adolescents is a very special issue and is focus of attention globally for various reasons. An essential component in the prevention and management of diseases is the adoption of a healthy lifestyle that would include the promotion of non-smoking, eating a healthy balanced diet, and actively engaging in organized physical activities Methods: The main objective of the study was to determine the impact of integrated training program on behavioural outcome of adolescents regarding lifestyle pattern. The research design selected for this study was Pre-experimental - One group pre test post-test design. 500 adolescents were selected from selected schools of Mysuru through convenience sampling technique. Socio demographic Proforma was used to assess the selected socio demographic variables of adolescents. Structured knowledge questionnaire, self administered attitude scale and adolescent lifestyle practice scale was to assess the knowledge, attitude and practice of adolescents regarding lifestyle pattern. Results: The results of the study revealed that Knowledge, attitude and practice of adolescents were improved after implementation of Integrated Training Program. There was significant difference between pretest and post test knowledge, pre-test and post test attitude, pre-test and post test practice score after the Integrated training program Conclusion: The study concluded that integrated training program is effective in enhancing the knowledge, attitude and practice of adolescents regarding lifestyle pattern | 616ff193dd0e7eb235b460b0a2c71691c05df417 | Crossref | Education | null | DOI:10.52711/ijnmr.2023.34 |
226,737,149 | pes2o/s2ag | v3-fos-license | 2020-10-28T18:50:37.986Z | 2020-01-01T00:00:00.000 | Clinical Solutions: Factors and Problematic Situations from the Perspective of Doctors in a Large Russian City | This article focuses on the main results of a quantitative empirical study of clinical decisions made by doctors in medical institutions of various profiles in a large Russian city. The study was conducted in 2019 and is based on the results of the previous qualitative analysis stage — within the research “mix-strategy”. The main point of analytical interest is the factors which influence the doctors’ clinical decisions in two basic clinical situations — in the situation of disease diagnosis and in the situation of treatment prescription. The object of the research was doctors from Samara medical clinics. Factors and decisions made by doctors were studied from the point of view of doctors themselves. The degree of influence of each factor on the decisions made by doctors was assessed with the help of the Influence Index, an integral index on a fully ordered scale. The article presents a hierarchy of factors influencing medical decision-making in diagnosis and treatment situations; the top group of factors in both situations is identified and interpreted. At the same time, additional problematic situations were studied in the research. In particular, the range of clinical decisions and factors determining them, in case of it being necessary to conduct an examination not provided by standard state medical care, in a situation when this examination is provided, but the limit of prescriptions is exhausted, in a situation when the medical institution (hospital) does not have the best quality medication for the patient in the quantities needed, in a situation when the state standard on a specific nosology is ineffective for a specific patient, as well as other problematic situations. | 46c47c6a92039ce1c69022e56802d14ae620828c | MAG, Crossref, Unpaywall | Medicine | Sociology | DOI:10.19181/socjour.2020.26.3.7398, MAG:3088768247 |
234,207,206 | pes2o/s2ag | v3-fos-license | 2021-05-11T00:06:18.589Z | 2021-01-01T00:00:00.000 | The Virtues and Limitations of Dynamic Capabilities | Dynamic capabilities have been identified as a key determinant of competitive advantage. This paper explores the foundations of dynamic capabilities, and the limits to their effectiveness, first theoretically and then through the case of Danaher, the most successful US conglomerate for over three decades. Limitations of dynamic capabilities include that they (a) can be substitutable and (b) embody strategic choices themselves. The Danaher case, an exemplar of dynamic capabilities, illustrates how dynamic capabilities require long-term commitments in order to be effective, involve a set of choices that are closely tied to others made by the firm, and embody tradeoffs that imply that investments in any particular dynamic capability may be inconsistent with acquiring new ones. | fa634ff47b64196b3dcbf1356727646140ae8ea3 | MergedPDFExtraction, Anansi, Crossref, MAG | Philosophy | Computer Science | DOI:10.1561/111.00000017, MAG:3129434652 |
36,684,643 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:50:46.032Z | 2005-08-19T00:00:00.000 | Mucormycosis in the Eastern Mediterranean: a seasonal disease | Mucormycosis is a fairly rare fungal infection caused by ubiquitous fungi of the order Mucorales and primarily affects immunocompromised hosts. A series of 16 cases of invasive mucormycosis admitted to three referral centres in Beirut, Lebanon between 1981 and 1999 is described. It includes 12 patients with rhinocerebral, three with cutaneous, and one with pulmonary infection. Onset of symptoms occurred in the summer and autumn in 15 out of 16 patients, showing a statistically significant seasonal variation (P=0·007) A recent report of 19 patients from Tel Aviv describes a strikingly similar seasonal pattern. Studies on atmospheric concentration of Mucorales spores in the Eastern Mediterranean are lacking. Weather pattern analysis in Beirut revealed clustering of onset of invasive mucormycosis at the end of a dry, warm period, which begins around May and ends in October. Mucormycosis incidence appears to be seasonal in the Eastern Mediterranean. | de5408694973e2cd11db74e84b7a221c749cc7cd | MAG, Medline, Cambridge, Unpaywall, MergedPDFExtraction | Environmental Science, Medicine | Medicine, Computer Science, Geography, Biology | DOI:10.1017/S0950268805004930, MAG:2914310826 |
7,436,243 | pes2o/s2ag | v3-fos-license | 2018-04-03T03:38:04.769Z | 2007-11-07T00:00:00.000 | Asymmetric sulfur ylide reactions with boranes: scope and limitations, mechanism and understanding. | The reactions of aryl-stabilized sulfur ylides with organoboranes has been studied under a variety of conditions. At 5 or -78 degrees C, the reaction with Et3B gave a mixture of the first and second homologation products, but at -100 degrees C, only the first homologation product was obtained even with just 1.1 equiv of Et3B. Under these optimized conditions, the chiral sulfur ylides (derived from camphor sulfonic acid) with different aryl groups were reacted with Et3B to give the corresponding alcohols (95-98% yield, 96-98% ee) and amines (74-77% yield, >98% ee). The origin of the high enantioselectivity is discussed. The use of nonsymmetrical 9-BBN derivatives was also explored. It was found that whereas primary alkyl substituents gave mixtures of products derived from competing migration of the boron substituent and the boracycle, all other groups resulted in either exclusive migration of the boron substituent (Ph, hexenyl, i-Pr) or exclusive migration of the boracycle (hexynyl, cyclopropyl). The factors responsible for the outcome of the reactions involving a hindered (i-Pr) and an unhindered (propynyl) substituent were studied by DFT calculations. This revealed that, in the case of an unhindered substituent, the conformation of the ate complex is the dominant factor whereas, in the case of a hindered substituent, the barriers to interconversion between the conformers of the ate complex and subsequent migration control the outcome of the reaction. | bd446b0162c6b870c10ea6a86186a8e8d3063ead | Unpaywall, Medline, MAG | Chemistry | Chemistry, Medicine | DOI:10.1021/JA074110I, MAG:1995491145 |
268,599,860 | pes2o/s2ag | v3-fos-license | 2024-03-22T15:45:02.765Z | 2024-03-19T00:00:00.000 | A potential solution for suspended solids accumulation on a tidally inundated stormwater canal in Valparaiso Bay, Chile | Low-relief coastal cities have experienced increased flooding due to climate change. During high tides or swell surges, stormwater canals or pipes can be inundated by coastal waters, causing suspended solids (SS) to accumulate at the conduits’ outfall. The City of Valparaiso (Chile) is currently upgrading its stormwater network with costly underground stormwater aqueducts such as the coastal “Argentina stormwater underground canal” (ASC). However, soon after the ASC was put in operation, sea water intrusion and bidirectional flow at the lowest sectors of the canal decreased its water conveying capacity, and SS (that otherwise would have been carried to Valparaiso Bay) accumulated in the lower sectors of the canal, close to its outfall. Urban growth and reduction of pervious land covers could worsen the current situation. Therefore, the current ASC outfall seems to be an unsustainable solution to conveyance of rainwater and SS. In this research, a hydrodynamic model of Valparaiso Bay and the ASC is presented. The current ASC hydrodynamic regime is described. The validated hydrodynamic model is used to explore the feasibility of using a submarine outfall to transport the accumulated muddy water to an offshore location. The effects of sea level rise on the existing stormwater canal are studied, and its potential to further prevent an efficient conveyance of rainwater from the city to Valparaiso Bay is explored. | 4c6e7a866f644256dd6e59fe8de8b7990ba6ab6c | Crossref | Environmental Science, Engineering | null | DOI:10.1680/jwama.23.00035 |
16,938,310 | pes2o/s2ag | v3-fos-license | 2014-10-01T00:00:00.000Z | 2005-01-01T00:00:00.000 | INTELLIGENT AGENT CONTROL USING INDUCTIVE , DEDUCTIVE AND CASE BASED REASONING | The paper deals with the problem of intelligent system’s design for complex environments. A possibility to integrate several technologies into one basic structure that could form a kernel of an intelligent system or intelligent agent has been discussed. An alternative structure is proposed in order to form the basis of an intelligent system that would be able to operate in complex environments. The proposed structure is very flexible because of features that allow adaptation via learning and adjustment of the used knowledge. Therefore, the proposed structure may be used in environments with stochastic features such as hardly predictable events or elements (intelligent entities). This paper discusses a possibility to use the proposed structure in order to model intelligent entities or entire intelligent systems for hardly predictable environments or environments with stochastic features in agent based modeling domains [Ref. 18,19]. The basic elements of the proposed structure have found their implementation in a software system and an experimental robotic system. The software system as well as the robotic system have been used for experimentation in order to validate the proposed structure its functionality, flexibility and reliability. Both of them are shortly presented in the paper. The basic features of each system are presented as well. The most important results of experiments are outlined and discussed at the end of the paper. Some possible directions of further research are also sketched at the end of the paper. | 19a071f8d0db18a6ec6c8e58dd1f3fa9ca4f22fc | Anansi, Grobid, CiteSeerX, Crawler, ScienceParseMerged | Computer Science | null | null |
42,157,410 | pes2o/s2ag | v3-fos-license | 2018-04-03T05:13:57.776Z | 2007-10-30T00:00:00.000 | Benign Fasciculations and other poems | One day, unprovoked,
a small snake ripples
in my thigh, unbidden as a tic
around the eye. Something
broken to congeal the honey
in my flesh,
a beehive gone awry.
Under a harsh light, you
report the nexus spread
like a brush-fire’s nascent flame
to calves and head.
A syncopated wave
of muscular babble
unrecruited by anything
I’ve done or said, and then
I tell you I’m dead;
a droplet poised
at the end of life’s spout.
Just a few months
’till my spinal cord rots,
breath is snuffed, and crawlers
pick my femurs clean.
At night I shout,
pursued by visions
of catacombs, of men I’ve tended,
slowly wasted to … | a07625b5d1807bf1804663c4e0818c25f95906f7 | Highwire, Unpaywall, MAG, Medline | Art | Medicine | DOI:10.1212/01.wnl.0000278107.94538.e6, MAG:2123974393 |
233,816,215 | pes2o/s2ag | v3-fos-license | 2021-05-07T00:03:11.413Z | 2021-03-05T00:00:00.000 | Transmission performance of FSO using 2μm wavelength laser | In this paper, we propose free space optical (FSO) communication using laser light in the 2μm wavelength. FSO using the mid-infrared 2μm band can reduce the effects of turbulence and particles generated in free space and improve link performance. In addition, it has a large allowable exposure because it can be operated in a transparent window in the atmosphere or in a safety for human eyes. We will analysis link visibility, transmission characteristics and SNR of 2μm FSO, demonstrate the BER of the FSO link with fog experimentally. The theoretical analysis will show that visibility and transmission loss will be improved by 2μm FSO, and experimental results also show that BER performance can be improved about 2dB. | 45c7edce96ac736809193a6a5f526cb9e2386174 | MAG, Crossref, MergedPDFExtraction | Physics | Physics | DOI:10.1117/12.2577480, MAG:3133633483 |
12,134,565 | pes2o/s2ag | v3-fos-license | 2017-11-20T18:26:46.092Z | 2017-06-01T00:00:00.000 | A Tomography of Full-Duplex Cellular Networks | Full-duplex (FD) networks promise nearly doubled spectrum efficiency for single links with beyond 100 dB self-interference cancellation capability. However, the performance of FD networking is not that straightforward, as there will be several new types of interference introduced. Hence, it is critical to exploit some radio resource management techniques to combat the annoying interference and inevitably needs to reserve part of radio resources in HD mode to obtain the essential auxiliary information. It is naturally to ask which physical channels and signals could be left in the FD mode and how much system gain FD cellular networks could bring? In this paper, we try to answer these questions. We first propose the feasibility to leave one kind of physical channels or signals in the FD mode and then highlight some potential resource management schemes. We will also demonstrate the system gain of FD networks by leveraging our proposed design and the management techniques. Our simulation results show FD communications leads to promising performance improvement. | b78ea2bf3a561b3592fecd37f1116c96d17819be | ScienceParseMerged, DBLP, IEEE, Unpaywall, MAG | Computer Science, Engineering | Computer Science | DOI:10.1109/VTCSpring.2017.8108362, MAG:2768325878 |
41,964,025 | pes2o/s2ag | v3-fos-license | 2018-04-03T05:11:38.153Z | 2006-06-22T00:00:00.000 | Critical behavior of entropic shear rigidity. | We report on extensive molecular dynamics (MD) simulations of a model for gels in both two and three dimensions. The model consists of randomly cross-linked monomers with a concentration p of cross-links above the percolation concentration so that the system is in the amorphous solid phase. As the concentration of cross-links approaches the percolation concentration, the entropic shear modulus vanishes as G approximately(p-p(c))(t) with t approximately 1.9 in three dimensions and t approximately 1.3 in two dimensions. These results hold whether or not the background fluid consisting of finite clusters is retained in the system. These results are also consistent with our previous calculations and with a conjecture of de Gennes but not with recent analytical results and another body of simulations. | 4474c2f6a19f65667087a2c464d330f31980b01a | Medline, MAG, Unpaywall | Materials Science, Physics | Materials Science, Medicine | DOI:10.1103/PHYSREVE.73.061406, MAG:2051343765 |
20,084,375 | pes2o/s2ag | v3-fos-license | 2018-04-03T04:35:44.288Z | 2007-05-01T00:00:00.000 | Sleep study, home or office? Pro | This question essentially translates as ‘when can an unattended limited home sleep study substitute for attended in-hospital polysomnography (PSG) in the investigation of obstructive sleep apnoea syndrome (OSAS)?’ The official American position remains ‘hardly ever’1 and advocates of PSG (Type I study, American Academy of Sleep Medicine classification) cite lack of validation data for some equipment, failed study rates up around 20% plus an inability to evaluate sleep status or diagnose non-OSAS conditions as major limitations of portable devices, unattended or attended.2 However, PSG is itself an imperfect ‘gold standard’ not immune from criticism regarding deficiencies in standardization and ‘fitness for purpose’.3,4 In one prospective study, six of 11 subjects with high clinical suspicion for OSAS required a second PSG study for a positive diagnosis.5 Sequential testing both for diagnostic purposes and monitoring clinical progress is a much more feasible proposition with home study equipment and is perhaps currently underexploited. Even in the United States, the bastion of PSG, opinions appear to be shifting and now acknowledge home Type III studies as an acceptable approach for medically stable patients with a moderate or high clinical risk of OSAS.6 The recent paper from Whitelaw et al.7 demonstrating virtually identical outcomes for OSAS diagnosed by oximetry compared with OSAS diagnosed by PSG is compelling evidence that in a preselected population Type IV studies also have a role. The Edinburgh group have shown that home studies can reduce PSG requirement and diagnostic costs.8 For many sleep services, the real value of the home or office debate nowadays is to guide the development of robust clinical pathways built around home study protocols. A concern with Type III or IV studies is that OSAS may be wrongly ‘eliminated’ on the basis of a negative study or another diagnosis such as periodic leg movement syndrome is overlooked (potentially more misleading is where a home study suggests OSAS when another cause is the principal issue). A service employing these tests requires safeguards. Detailed clinical assessment of pretest probability for OSAS is a crucial first step9 so that the degree of concordance or discordance with study data (taking account of study quality) defines a structured programme of response. The key principles are as follows: | c39ead51859b6cf84c1e0c33f37bad236f4cb1ce | MAG, Unpaywall, MergedPDFExtraction, Sage, Medline | Medicine | Medicine | DOI:10.1177/1479972307078105, MAG:2031931239 |
256,152,258 | pes2o/s2ag | v3-fos-license | 2023-01-24T16:56:54.356Z | 2023-01-01T00:00:00.000 | A Review on Biological Activities of Indian Traditional Medicinal Plant: Calotropis Gigantea | India, which is aptly referred to as the world's botanical garden, is the country that produces the most medicinal herbs. The Apocynaceae/Asclepiadaceae family member, Calotropis gigantea sometimes known as the Crown Flower, has special therapeutic characteristics that can be used on its own or in combination with other drugs to treat common illnesses. There is a surprising therapeutic diversity in herbal medications. Entire dried plant is employed as rejuvenating, parasitic worm expellers and mucus explusors in ayurveda. While latex of it cures vertigo, baldness, hair loss, and rheumatoid arthritis, and to treat asthma root in dry form is used, leprosy. Calotropis is employed as a homoeopathic remedy in addition to its conventional purposes. Significant medicinal benefits can be obtained from the plant's extracts from its many components. It is necessary to objectively investigate these treatments in order to determine their active principles and comprehend their pharmacological properties, such as prophylactic protective, NSAID, antibacterial, antimicrobial, anti-oxidant, antiulcer ,helps in treating Covid-19, antimalarial, antipyretic, wound healing activity, cytotoxic properties, anti-asthmatic , procoagulant , CNS and anticonvulsant activity, pregnancy interceptive, anticancer, analgesic, antidiabetic, antidiarrheal, insecticidal, and hepatoprotective. It provides data about the mythical importance, herbal relevance, origin, pharmacogenetic illustration, herbal constituents, biological activities, and ethnopharmacological noteworthiness of Calotropis gigantea is summarized in the current review. | d3bb2491c07ef8cfcf3c3e6d0ebcda1ffd97f4c6 | Crossref | Biology | null | DOI:10.37191/mapsci-2582-4937-4(2)-028 |
253,072,358 | pes2o/s2ag | v3-fos-license | 2022-10-23T15:02:08.142Z | 2022-10-20T00:00:00.000 | Challenging Ergonomics Risks with Smart Wearable Extension Sensors | Concerning occupational safety, the aim of ergonomics as a scientific discipline is to study and adjust working conditions, worker equipment, and work processes from a psychological, physiological, and anatomical aspect instead of adapting the worker to the needs of the job. This paper will discuss and analyze the potential of the garment-embedded body posture tracking sensor and its usage as standard working equipment, which is meant to help correct improper and high-risk upper body positions during prolonged and static work activities. The analysis evaluation cross-reference is based on the Rapid Upper Limb Assessment ergonomics risk assessment tool. Signals generated by the wearable are meant to help the wearer and observer promptly-continuously detect and correct bad posture. The results show a positive progression of workers’ body posture to reduce the ergonomic risks this research covers. It can be concluded that wearable technology and sensors would significantly contribute to the observer as the evaluation tool and the wearer to spot the risk factors promptly and self-correct them independently. This feature would help workers learn and improve the correct habits of correcting ergonomically incorrect body postures when performing work tasks. | 8b551dba0f4d138397a0f61fd42f369633d9f922 | MergedPDFExtraction, Anansi, Crossref, ScienceParsePlus | Engineering, Environmental Science, Medicine | null | DOI:10.3390/electronics11203395 |
14,449,855 | pes2o/s2ag | v3-fos-license | 2014-10-01T00:00:00.000Z | 2007-01-01T00:00:00.000 | FPGA Architectures for Reconfigurable Computing | To accelerate the execution of an application, repetitive logic and arithmetic computation tasks may be mapped to reconfigurable hardware, since dedicated hardware can deliver much higher speeds than those of a general-purpose processor. However, this is only feasible if the run-time reconfiguration of new tasks is fast enough, so as not to delay application execution. Currently, this is opposed by architectural constraints intrinsic to current Field-Programmable Logic Array (FPGA) architectures. Despite all new features exhibited by current FPGAs, architecturally they are still largely based on general-purpose architectures that are inadequate for the demands of reconfigurable computing. Large configuration file sizes and poor hardware and software support for partial and dynamic reconfiguration limits the acceleration that reconfigurable computing may bring to applications. The objective of this work is the identification of the architectural limitations exhibited by current FPGAs that prevent reconfigurable computing systems to achieve a high efficiency and performance and the proposal of alternatives to its resolution. | 7340f896fc25fe337617a4a3bdebf098cc4f4adc | Anansi, Crawler, CiteSeerX, ScienceParseMerged, Grobid | Computer Science, Engineering | null | null |
26,156,505 | pes2o/s2ag | v3-fos-license | 2017-06-17T08:29:54.057Z | 2010-10-01T00:00:00.000 | Effects of stage of lactation and dietary concentrate level on energy utilization by Alpine dairy goats. | Twenty-four lactating and 13 nonlactating Alpine goats were used to determine effects of stage of lactation and dietary concentrate level on energy utilization. Diets comprising 60 or 20% concentrate (60%C and 20%C, respectively) were consumed ad libitum by lactating animals and at a level of intake near maintenance by nonlactating animals. Measurement periods were d 25 to 31 (early), 87 to 94 (mid), and 176 to 183 (late) of lactation. Eleven observations were made in early and mid lactation for each diet, and 8 and 7 were made in late lactation for the 60%C and 20%C diets, respectively. Efficiency of metabolizable energy (ME) use for maintenance (66.9, 71.4, and 61.1% for early, mid, and late lactation, respectively) and the maintenance ME requirement (479, 449, and 521 kJ/kg of BW(0.75) for early, mid, and late lactation, respectively) determined with nonlactating animals differed among stages of lactation. The efficiency of ME use for maintenance was similar between diets, but the maintenance requirement tended to be greater for the 60%C than for the 20%C diet (504 vs. 463 kJ/kg of BW(0.75)). The latter difference may have involved greater ME intake for the 60%C diet, resulting in a slightly greater difference between ME intake and total heat energy for the 60%C compared with the 20%C diet (11 vs. -8 kJ/kg of BW(0.75)). Intake of ME by lactating goats was greater for the 60%C than for the 20%C diet (18.6 vs. 16.3 MJ/d). Recovered energy in lactation from mobilized tissue tended to be greater for the 60%C than for the 20%C diet (8.44 vs. 6.55 MJ/d) and differed among stages of lactation (2.60, 1.59, and 1.13 MJ/d in early, mid, and late lactation, respectively). Recovered energy in tissue gain was similar among stages of lactation and between diets and was not different from 0. Efficiency of use of dietary ME for lactation differed among stages of lactation (59.5, 51.9, and 65.4% for early, mid, and late lactation, respectively) and tended to be greater for the 60%C than for the 20%C diet (64.2 vs. 54.9%). The efficiency of use of dietary ME for maintenance and lactation was similar among stages of lactation and was greater for the 60%C compared with the 20%C diet (64.3 vs. 60.9%). Predicted milk yield from National Research Council requirements was reasonably accurate. In conclusion, using data of nonlactating goats to study energy utilization for maintenance in lactation has limitations. Efficiency of energy use by lactating dairy goats consuming diets high in concentrate appears greater than that by goats consuming diets low in concentrate. Despite differences in nutrient requirement expressions, observations of this study support National Research Council recommendations of energy requirements of lactating dairy goats. | 555cd6d31a62bf52cf064a0bcb96a73869eecbf5 | Medline, ScienceParseMerged, Unpaywall, MAG, Anansi | Agricultural and Food Sciences | Biology, Medicine | DOI:10.3168/jds.2010-3315, MAG:2088868843 |
245,541,155 | pes2o/s2ag | v3-fos-license | 2021-12-30T14:10:56.601Z | 2021-11-23T00:00:00.000 | An Overview of Digital Predistortion Solutions for Hybrid Beamforming Mimo Transmitters | U ovom radu dat je pregled postojećih rešenja digitalne predistorzije za hybrid bemforming MIMO (multiple-input multiple-output) predajnike. Pored opisa samih modela, izložena je i uporedna analiza modela u pogledu performansi. Takođe, ukazano je na neke od mogućih problema pri primeni predloženih tehnika digitalne predistorzije u budućim širokopojasnim sistemima.This paper provides an overview of existing digital predistortion solutions for hybrid bemforming MIMO (multiple-input multiple-output) transmitters. In addition to the description of the models, their comparative analysis, in terms of model performance, is also presented. Some of the possible problems in the application of the proposed digital predistortion techniques in future broadband systems have also been pointed out. | a7b0b1e3ffc59694b8aeb6fbebee6aa3db6d6ec1 | Crossref, IEEE | Engineering, Computer Science | null | DOI:10.1109/TELFOR52709.2021.9653422 |
134,896,355 | pes2o/s2ag | v3-fos-license | 2019-04-27T13:13:28.437Z | 2019-07-01T00:00:00.000 | A lost Tethyan evaporitic basin: Evidence from a Cretaceous hemipelagic meta‐selenite – red chert association in the Eastern Mediterranean realm | Ancient evaporite deposits are geological archives of depositional environments characterized by a long‐term negative precipitation balance and bear evidence for global ocean element mass balance calculations. Here, Cretaceous selenite pseudomorphs from western Anatolia (‘Rosetta Marble’) — characterized by their exceptional morphological preservation — and their ‘marine’ geochemical signatures are described and interpreted in a process‐oriented context. These rocks recorded Late Cretaceous high‐pressure/low‐temperature, subduction‐related metamorphism with peak conditions of 1·0 to 1·2 GPa and 300 to 400°C. Metre‐scale, rock‐forming radiating rods, now present as fibrous calcite marble, clearly point to selenitic gypsum as the precursor mineral. Stratigraphic successions are recorded along a reconstructed proximal to distal transect. The cyclical alternation of selenite beds and radiolarian ribbon‐bedded cherts in the distal portions are interpreted as a two type of seawater system. During arid intervals, shallow marine brines cascaded downward into basinal settings and induced precipitation. During more humid times, upwelling‐induced radiolarian blooms caused the deposition of radiolarite facies. Interestingly, there is no comparable depositional setting known from the Cenozoic world. Meta‐selenite geochemical data (δ13C, δ18O and 87Sr/86Sr) plot within the range of reconstructed middle Cretaceous seawater signatures. Possible sources for the 13C‐enriched (mean 2·2‰) values include methanogenesis, gas hydrates and cold seep fluid exhalation. Spatially resolved component‐specific analysis of a rock slab displays isotopic variances between meta‐selenite crystals (mean δ13C 2·2‰) and host matrix (mean δ13C 1·3‰). The Cretaceous evaporite‐pseudomorphs of Anatolia represent a basin wide event coeval with the Aptian evaporites of the Proto‐Atlantic and the pseudomorphs share many attributes, including lateral distribution of 600 km and stratigraphic thickness of 1·5 to 2·0 km, with the evaporites formed during the younger Messinian salinity crisis. The Rosetta Marble of Anatolia may represent the best‐preserved selenite pseudomorphs worldwide and have a clear potential to act as a template for the study of meta‐selenite in deep time. | 368c367b819eab26bf505ebbde3c92080a7309eb | MAG, Unpaywall, MergedPDFExtraction, Crossref, Wiley | Geology, Environmental Science | Geology | DOI:10.1111/sed.12606, MAG:2922739971 |
145,545,455 | pes2o/s2ag | v3-fos-license | 2019-05-06T14:06:44.201Z | 2011-02-01T00:00:00.000 | Barry Hindess and the Critique of Democracy | In the wake of the collapse of the Communist regime in the Soviet Union, liberal democracy was triumphantly celebrated as the “end of history.” Against this backdrop, Hindess wrote a number of critical essays launching his intellectual critique of liberal democracy. His approach was primarily conceptual, highlighting the problems and weaknesses of the conceptualization of democracy and democratization. This article reviews and offers a brief assessment of the key arguments made in Hindess' writings on democracy and democratization. In particular, it attempts to summarize the methodological steps through which Hindess engages conceptual critique. While offering an appreciation of Hindess'analysis, insight, and intellectual integrity, it also addresses some difficulties in his arguments. | 5d62534d5be206a2b5c7186817c5c8a9650bc828 | Unpaywall, Sage, MergedPDFExtraction, MAG | Political Science, Philosophy | Sociology | DOI:10.1177/0304375411401834, MAG:2105248061 |
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