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22,704,821 | 2012-10-25 | 2012-07-10 | 0870-2551 | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology | [Left ventricular assist device in a five-year-old child: a bridge to recovery in a case of viral myocarditis]. | Silva Margarida, Carvalho Nuno, Nogueira Graça, Costa Patrícia, Rodrigues Rui, Abecasis Miguel, Nunes Manuela, Anjos Rui, Neves José | por | null | Case Reports, English Abstract, Journal Article | null | IM | 22704821, S0870-2551(12)00128-X, 10.1016/j.repc.2012.05.006 | Viral myocarditis can lead to heart failure that is refractory to medication. In these cases, a ventricular assist device is a good therapeutic option that can be used as a bridge to transplantation or recovery. We describe the first case in Portugal of recovery with ventricular assistance after severe myocarditis. | Child, Preschool, Heart-Assist Devices, Humans, Male, Myocarditis | null |
22,704,829 | 2012-11-05 | 2016-11-25 | 1873-2976 | Bioresource technology | Bioregeneration of mono-amine modified silica and granular activated carbon loaded with Acid Orange 7 in batch system. | Al-Amrani Waheeba Ahmed, Lim Poh-Eng, Seng Chye-Eng, Ngah Wan Saime Wan | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Amines, Azo Compounds, Benzenesulfonates, Charcoal, Silicon Dioxide, 2-naphthol orange | IM | 22704829, S0960-8524(12)00843-7, 10.1016/j.biortech.2012.05.090 | The objectives of this study were: (1) to investigate the role of mixed culture of biomass in the regeneration of mono-amine modified silica (MAMS) and granular activated carbon (GAC) loaded with Acid Orange 7 (AO7), (2) to quantify and compare the bioregeneration efficiencies of AO7-loaded MAMS and GAC using the sequential adsorption and biodegradation approach and (3) to evaluate the reusability of bioregenerated MAMS. The results show that considerably higher bioregeneration efficiency of AO7-loaded MAMS as compared to that of AO7-loaded GAC was achieved due to higher reversibility of adsorption of MAMS for AO7 and favorable pH factor resulting in more AO7 desorption. The progressive loss of adsorption capacity of MAMS for AO7 with multiple cycles of use suggests possible chemical and microbial fouling of the adsorption sites. | Adsorption, Amines, Azo Compounds, Batch Cell Culture Techniques, Benzenesulfonates, Biodegradation, Environmental, Biological Oxygen Demand Analysis, Charcoal, Recycling, Silicon Dioxide, Time Factors | null |
22,704,830 | 2012-11-05 | 2012-07-04 | 1873-2976 | Bioresource technology | Influence of airflow intensity on phytase production by solid-state fermentation. | Rodríguez-Fernández D E, Rodríguez-León J A, de Carvalho J C, Karp S G, Sturm W, Parada J L, Soccol C R | eng | null | Journal Article | 6-Phytase | IM | 22704830, S0960-8524(12)00776-6, 10.1016/j.biortech.2012.05.032 | Phytase production by Aspergillus niger F3 by solid state fermentation (SSF) on citrus peel was evaluated at pilot scale under different aeration conditions. The best airflow intensity was 1 VkgM (Lair kg medium(-1) min(-1)), which allowed to produce 65 units of phytases per gram in dry basis (65 Ug(-1) d.b.) as it removed the metabolic heat generated by the microorganism, Agitation did not improve heat removal. Airflow intensity was considered as scale-up criterion. When the airflow intensity was maintained at 1 VkgM for SSF with 2 and 20 kg of medium, the kinetics parameters for biomass and enzyme concentration at the end of fermentation differed by less than 2. The air flow intensity was required to maintain the temperature and cool the SSF and to provide oxygen for microbial growth. Air flow intensity is a key a factor that must be considered when scale-up of SSF is attempted. | 6-Phytase, Aerobiosis, Air Movements, Aspergillus niger, Biotechnology, Fermentation, Hot Temperature, Kinetics | null |
22,704,831 | 2012-11-05 | 2015-11-19 | 1873-2976 | Bioresource technology | Influence of TEMPO-mediated oxidation on the lignin of thermomechanical pulp. | Ma Pu, Fu Shaoling, Zhai Huamin, Law Kweinam, Daneault Claude | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Butyrates, Cyclic N-Oxides, Nitrobenzenes, erythronic acid, Ozone, Lignin, nitrobenzene, threonic acid, TEMPO | IM | 22704831, S0960-8524(12)00781-X, 10.1016/j.biortech.2012.05.037 | The influences of various factors in 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation on delignification, lignin aromatic ring and side chain structures of thermomechanical pulp (TMP) were investigated. The results indicate neither TEMPO nor NaBr alone can provoke changes in lignin content or lignin structure under weakly alkaline conditions. However, NaClO and NaClO-NaBr were able to remove lignin effectively, causing remarkable changes in lignin structure. Delignification was promoted when TEMPO was used with NaBr and NaClO. In contrast to NaClO alone, an additional 15% lignin was removed when TEMPO-mediated oxidation system was used, but it did not induce further changes on lignin structure. Increased doses of oxidizing agent and reaction time also improved the oxidation of cellulose and delignification, but they did not have a significant impact on lignin aromatic and side chain structures. | Butyrates, Cyclic N-Oxides, Lignin, Mechanical Phenomena, Nitrobenzenes, Oxidation-Reduction, Ozone, Paper, Temperature | null |
22,704,833 | 2012-12-19 | 2012-10-04 | 1549-4713 | Ophthalmology | Lessons learned: wrong intraocular lens. | Schein Oliver D, Banta James T, Chen Teresa C, Pritzker Scott, Schachat Andrew P | eng | null | Case Reports, Journal Article | null | IM | 22704833, S0161-6420(12)00354-5, 10.1016/j.ophtha.2012.04.011 | To report cases involving the placement of the wrong intraocular lens (IOL) at the time of cataract surgery where human error occurred. | Cataract Extraction, Device Removal, Humans, Lens Implantation, Intraocular, Lenses, Intraocular, Medical Errors, Optics and Photonics, Reoperation, Retrospective Studies, Risk Management, Visual Acuity | null |
22,704,832 | 2012-12-19 | 2022-03-31 | 1549-4713 | Ophthalmology | Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. | Galor Anat, Karp Carol L, Oellers Patrick, Kao Andrew A, Abdelaziz Amany, Feuer William, Dubovy Sander R | eng | P30 EY014801 (NEI NIH HHS, United States); P30EY014801 (NEI NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S. | Mitomycin, Interferons, Fluorouracil | IM | 22704832, S0161-6420(12)00365-X, 10.1016/j.ophtha.2012.04.022, PMC3459154, NIHMS372847, 9215061, 19908234, 19899994, 22189448, 10832683, 7660300, 18294690, 11805500, 8600883, 11874759, 2325992, 19125065, 14508267, 20639761, 14693762, 20498858, 9400769, 3951824, 17623583, 10209445, 7257061, 20455848, 9395829, 2929703, 22157595, 9082277, 19493859, 11888082, 8291600, 3301209, 9194740, 12642297, 20861726, 19617789, 12640411 | To identify predictors of ocular surface squamous neoplasm (OSSN) recurrence after operative resection. | Adult, Aged, Aged, 80 and over, Carcinoma in Situ, Carcinoma, Squamous Cell, Conjunctival Neoplasms, Corneal Diseases, Cryotherapy, Eye Neoplasms, Female, Fluorouracil, Humans, Interferons, Male, Middle Aged, Mitomycin, Neoplasm Recurrence, Local, Ophthalmologic Surgical Procedures, Retrospective Studies, Risk Factors, Young Adult | null |
22,704,834 | 2012-12-19 | 2022-03-31 | 1549-4713 | Ophthalmology | Treatment of conjunctival and corneal epithelial neoplasia with retinoic acid and topical interferon alfa-2b: long-term follow-up. | Krilis Matthew, Tsang Hughie, Coroneo Minas | eng | null | Journal Article | Antineoplastic Agents, Interferon alpha-2, Interferon-alpha, Ophthalmic Solutions, Recombinant Proteins, Tretinoin | IM | 22704834, S0161-6420(12)00313-2, 10.1016/j.ophtha.2012.03.045 | To evaluate the long-term recurrence rate of conjunctival and corneal intraepithelial neoplasia (CIN) treated with retinoic acid and topical interferon alfa-2b. | Administration, Topical, Antineoplastic Agents, Carcinoma in Situ, Conjunctival Neoplasms, Corneal Diseases, Drug Therapy, Combination, Eye Neoplasms, Female, Follow-Up Studies, Humans, Interferon alpha-2, Interferon-alpha, Male, Neoplasm Recurrence, Local, Ophthalmic Solutions, Recombinant Proteins, Retrospective Studies, Treatment Outcome, Tretinoin | null |
22,704,835 | 2013-05-03 | 2012-11-20 | 1872-6976 | Archives of gerontology and geriatrics | Low-dose cerebral CT perfusion imaging (CTPI) of senile dementia: diagnostic performance. | Tang Zhen, Chen Feng, Huang Jie, Shi Linghua, Gong H T, Fu Hongmei, Qu Zhengwan, Pi Xiaoling | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22704835, S0167-4943(12)00119-7, 10.1016/j.archger.2012.05.009 | To evaluate the clinical value of low-dose cerebral CTPI in the diagnosis of senile dementia, as an attempt to develop a new imaging method to diagnose this disease and measure its severity. 95 patients of senile dementia (52 with Alzheimer's disease (AD), 43 with vascular dementia (VD)) and 30 healthy subjects (control group) were underwent low-dose cerebral CTPI examinations with multi-slices spiral CT. The CTPI images were analyzed using perfusion software. Derived perfusion parameters including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) were measured. Diagnostic value of perfusion parameters was evaluated by receiver-operating characteristic (ROC) curve. The CBV and CBF of both of frontal lobe, temporal lobe, hippocampus and basal ganglial area in the patients with senile dementia were much lower than those in the healthy group. And MTT and TTP of the areas above-mentioned in the senile dementia group were higher than those in the control group. There was statistically significant difference between them (p<0.05). The areas under ROC curves of perfusion parameters left temporal lobe MTT, left the basal ganglia MTT and left the hippocampus MTT to diagnose senile dementia were 0.959, 0.920, 0.916, and diagnostic accuracy rate is higher. The areas under ROC curve of the left frontal MTT, the left basal ganglia CBV were 0.867 and 0.819, diagnosis accuracy medium. The results showed that cerebral CTPI is valuable for the diagnosis of senile dementia. | Aged, Aged, 80 and over, Alzheimer Disease, Brain, Case-Control Studies, Cerebrovascular Circulation, Dementia, Vascular, Female, Humans, Male, Middle Aged, Neuroimaging, Perfusion Imaging, ROC Curve, Severity of Illness Index, Tomography, Emission-Computed | null |
22,704,836 | 2013-09-06 | 2018-12-02 | 1873-1457 | Physics of life reviews | Survival of the pre-fittest: Commentary to N. Takeuchi and P. Hogeweg review article "Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life". | Di Mauro Ernesto | eng | null | Journal Article, Comment | RNA | IM | 22704836, S1571-0645(12)00054-1, 10.1016/j.plrev.2012.06.007 | null | Computational Biology, Evolution, Molecular, Origin of Life, RNA | null |
22,704,837 | 2013-09-06 | 2018-12-02 | 1873-1457 | Physics of life reviews | Comments on "Evolutionary dynamics of RNA-like replicator systems". | Higgs Paul G | eng | null | Journal Article, Comment | RNA | IM | 22704837, S1571-0645(12)00057-7, 10.1016/j.plrev.2012.06.010 | null | Computational Biology, Evolution, Molecular, Origin of Life, RNA | null |
22,704,840 | 2013-04-25 | 2012-11-12 | 1873-4235 | Biosensors & bioelectronics | Nanochannels for diagnostic of thrombin-related diseases in human blood. | de la Escosura-Muñiz Alfredo, Chunglok Wilanee, Surareungchai Werasak, Merkoçi Arben | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Thrombin | IM | 22704840, S0956-5663(12)00314-4, 10.1016/j.bios.2012.05.021 | A high sensitive voltammetric method for rapid determination of thrombin spiked in whole blood by taking advantage of both aptamer-based recognition and the use of a nanoporous membrane has been developed. The nanoporous membrane not only acts as platform for the thrombin recognition but also as filter of the micrometric components such as white and red blood cells, consequently minimizing matrix effects. The protocol involves a sandwich format in the inner walls (200 nm diameter) of an anodized alumina oxide filter membrane (AAO). The analytical signal, by DPV oxidation of [Fe(CN)(6)](4-), is based on the blockage in the pores which affects the diffusion of [Fe(CN)(6)](4-) to the screen-printed carbon electrotransducer (SPCEs) modified with the membrane. By labeling the anti-thrombin IgG with AuNPs followed by silver enhancement a greater passive signal enhancement in comparison to the membrane blockage has been observed. The contribution of both electrostatic/steric effects in this blockage due to the subsequent formation of the aptamer-thrombin complex and the final sandwich assay is investigated. The efficiency of the system is also monitored by microscopic techniques. The resulted biosensing system allows detecting thrombin spiked in whole blood at very low levels (LOD 1.8 ng mL(-1)) which are within the range of clinical interest for the diagnostic of coagulation abnormalities as well as pulmonary metastasis. | Biosensing Techniques, Blood Chemical Analysis, Conductometry, Equipment Design, Equipment Failure Analysis, Humans, Immunoassay, Nanotechnology, Reproducibility of Results, Sensitivity and Specificity, Thrombin | null |
22,704,841 | 2013-04-25 | 2013-11-21 | 1873-4235 | Biosensors & bioelectronics | Flexible, layered biofuel cells. | Miyake Takeo, Haneda Keigo, Yoshino Syuhei, Nishizawa Matsuhiko | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Fructose, Oxygen | IM | 22704841, S0956-5663(12)00353-3, 10.1016/j.bios.2012.05.041 | Similar to conventional electrolyte batteries, biofuel cells often need to be stacked in order to boost their single cell voltage (<1 V) up to a practical level. Here, we report a laminated stack of biofuel cells that is composed of bioanode fabrics for fructose oxidation, hydrogel sheets containing electrolyte and fuel (fructose), and O(2)-diffusion biocathode fabrics. The anode and cathode fabrics were prepared by modifying fructose dehydrogenase and bilirubin oxidase, respectively, on carbon nanotubes-decorated carbon fiber fabrics. The total thickness of the single set of anode/gel/cathode sheets is just 1.1mm. The laminated triple-layer stack produces an open-circuit voltage of 2.09 V, which is a 2.8-fold increase over that of a single set cell (0.74 V). The present layered cell (5 mm × 5 mm) produces a maximum power of 0.64 mW at 1.21 V, a level that is sufficient to drive light-emitting diodes. | Bioelectric Energy Sources, Elastic Modulus, Electrochemistry, Electrodes, Equipment Design, Equipment Failure Analysis, Fructose, Oxygen | null |
22,704,838 | 2013-02-07 | 2017-01-12 | 0392-856X | Clinical and experimental rheumatology | Anti-Ro52 antibody testing influences the classification and clinical characterisation of primary Sjögren's syndrome. | Retamozo Soledad, Akasbi Miriam, Brito-Zerón Pilar, Bosch Xavier, Bove Albert, Perez-de-Lis Marta, Jimenez Iratxe, Soto-Cardenas Maria-Jose, Gandia Miriam, Diaz-Lagares Candido, Viñas Odette, Siso Antoni, Perez-Alvarez Roberto, Yague Jordi, Ramos-Casals Manuel | eng | null | Journal Article | Antibodies, Antinuclear, Biomarkers, Ribonucleoproteins, SS-A antibodies, SS-A antigen, SS-B antibodies, Rheumatoid Factor | IM | 22704838, 5286 | To evaluate how determination of antibodies against the Ro52 antigen influences the classification and clinical characterisation of patients with suspected primary Sjögren's syndrome (SS). | Antibodies, Antinuclear, Biomarkers, Biopsy, Chi-Square Distribution, Enzyme-Linked Immunosorbent Assay, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prognosis, Rheumatoid Factor, Ribonucleoproteins, Salivary Glands, Sjogren's Syndrome | null |
22,704,842 | 2012-11-05 | 2022-03-18 | 1878-5905 | Biomaterials | The properties of Gd2O3-assembled silica nanocomposite targeted nanoprobes and their application in MRI. | Shao Yuanzhi, Tian Xiumei, Hu Wenyong, Zhang Yongyu, Liu Huan, He Haoqiang, Shen Yingying, Xie Fukang, Li Li | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Molecular Probes, gadolinium oxide, Silicon Dioxide, Gadolinium | IM | 22704842, S0142-9612(12)00619-9, 10.1016/j.biomaterials.2012.05.065 | The feasibility of the gadolinium-doped mesoporous silica nanocomposite Gd(2)O(3)@MCM-41 as a safe, effective MRI nanoprobe has been validated in the current investigation systematically from atomistic and molecular modeling to its synthesis and characterization on in vivo MR imaging and biocompatibility. The first-principles calculation indicates that it is nearly impossible for toxic Gd ions to dissociate freely from silica. The biocompatibility studies confirm that the nanocomposite is lack of any potential toxicity; the biodistribution studies reveal a greater accumulation of the nanocomposite in liver, spleen, lung and tumor than in kidney, heart and brain; the excretion studies show that the nanocomposite can be cleared nearly 50% via the hepatobiliary transport mechanism after 1.5 months of injection. A larger water proton relaxivity r(1) and a better T(1)-weighted phantom MR imaging capability were detected in the nanocomposite than in the commercially available gadolinium diethylenetriaminepentaacetate. The results demonstrate that the nanocomposite is superior to the commercial counterpart in terms of contrast enhancement with a satisfactory biocompatibility, and it has a high potential to be developed into a safe and effective targeted probe for in vivo molecular imaging of cancer. | Adsorption, Animals, Apoptosis, Cell Cycle, Cell Line, Cell Survival, Computer Simulation, Electrons, Gadolinium, Humans, Magnetic Resonance Imaging, Male, Materials Testing, Mice, Mice, Inbred BALB C, Molecular Probes, Nanocomposites, Silicon Dioxide, Tissue Distribution | null |
22,704,839 | 2012-12-10 | 2019-12-10 | 1873-4235 | Biosensors & bioelectronics | Rapid and sensitive detection of Nampt (PBEF/visfatin) in human serum using an ssDNA aptamer-based capacitive biosensor. | Park Jee-Woong, Kallempudi Sreenivasa Saravan, Niazi Javed H, Gurbuz Yasar, Youn Byung-Soo, Gu Man Bock | eng | null | Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't | Aptamers, Nucleotide, DNA, Single-Stranded, Nicotinamide Phosphoribosyltransferase | IM | 22704839, S0956-5663(12)00348-X, 10.1016/j.bios.2012.05.036 | A single-stranded DNA (ssDNA) aptamer was successfully developed to specifically bind to nicotinamide phosphoribosyl transferase (Nampt) through systematic evolution of ligands by exponential enrichment (SELEX) and successfully implemented in a gold-interdigitated (GID) capacitor-based biosensor. Surface plasmon resonance (SPR) analysis of the aptamer revealed high specificity and affinity (K(d)=72.52 nM). Changes in surface capacitance/charge distribution or dielectric properties in the response of the GID capacitor surface covalently coupled to the aptamers in response to changes in applied AC frequency were measured as a sensing signal based on a specific interaction between the aptamers and Nampt. The limit of detection for Nampt was 1 ng/ml with a dynamic serum detection range of up to 50 ng/ml; this range includes the clinical requirement for both normal Nampt level, which is 15.8 ng/ml, and Nampt level in type 2 diabetes mellitus (T2DM) patients, which is 31.9 ng/ml. Additionally, the binding kinetics of aptamer-Nampt interactions on the capacitor surface showed that strong binding occurred with increasing frequency (range, 700 MHz-1 GHz) and that the dissociation constant of the aptamer under the applied frequency was improved 120-240 times (K(d)=0.3-0.6 nM) independent on frequency. This assay system is an alternative approach for clinical detection of Nampt with improved specificity and affinity. | Aptamers, Nucleotide, Base Sequence, Biosensing Techniques, DNA, Single-Stranded, Diabetes Mellitus, Type 2, Electric Impedance, Equipment Design, Humans, Limit of Detection, Molecular Sequence Data, Nicotinamide Phosphoribosyltransferase, SELEX Aptamer Technique, Surface Plasmon Resonance | null |
22,704,844 | 2012-11-05 | 2022-03-30 | 1878-5905 | Biomaterials | Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide. | Chen Guan-Yu, Yang Hong-Jie, Lu Chia-Hsin, Chao Yu-Chan, Hwang Shiaw-Min, Chen Chiu-Ling, Lo Kai-Wei, Sung Li-Yu, Luo Wen-Yi, Tuan Hsing-Yu, Hu Yu-Chen | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Cytokines, Toll-Like Receptors, Graphite | IM | 22704844, S0142-9612(12)00618-7, 10.1016/j.biomaterials.2012.05.064 | Graphene oxide (GO) nanosheets have sparked growing interests in biological and medical applications. This study examined how macrophage, the primary immune cell type engaging microbes, responded to GO treatment. We uncovered that incubation of macrophage cell RAW264.7 with GO elicited autophagy in a concentration-dependent manner, as evidenced by the appearance of autophagic vacuoles and activation of autophagic marker proteins. Such GO-induced autophagy was observed in various cell lines and in macrophage treated with GO of different sizes. Strikingly, GO treatment of macrophage provoked the toll-like receptor (TLR) signaling cascades and triggered ensuing cytokine responses. Molecular analysis identified that TLR4 and TLR9 and their downstream signaling mediators MyD88, TRAF6 and NF-κB played pivotal roles in the GO-induced inflammatory responses. By silencing individual genes in the signaling pathway, we further unveiled that the GO-induced autophagy was modulated by TLR4, TLR9 and was dependent on downstream adaptor proteins MyD88, TRIF and TRAF6. Altogether, we demonstrated that GO treatment of cells simultaneously triggers autophagy and TLR4/TLR9-regulated inflammatory responses, and the autophagy was at least partly regulated by the TLRs pathway. This study thus suggests a mechanism by which cells respond to nanomaterials and underscores the importance of future safety evaluation of nanomaterials. | Animals, Autophagy, Cell Line, Cytokines, Gene Silencing, Graphite, Macrophages, Mice, Models, Biological, Nanoparticles, Signal Transduction, Toll-Like Receptors, Vacuoles | null |
22,704,843 | 2012-11-05 | 2013-11-21 | 1878-5905 | Biomaterials | Electrochemical control of cell death by reduction-induced intrinsic apoptosis and oxidation-induced necrosis on CoCrMo alloy in vitro. | Haeri Morteza, Wӧllert Torsten, Langford George M, Gilbert Jeremy L | eng | null | Journal Article | Alloys, Culture Media, Ions, Vitallium, Cobalt, Caspase 3, Caspase 9 | IM | 22704843, S0142-9612(12)00595-9, 10.1016/j.biomaterials.2012.05.054 | Electrochemical voltage shifts in metallic biomedical implants occur in-vivo due to a number of processes including mechanically assisted corrosion. These excursions may compromise the biocompatibility of metallic implants. Voltages can also be controlled to modulate cell function and fate. The in vitro effect of static voltages on the behavior of MC3T3-E1 pre-osteoblasts cultured on CoCrMo alloy (ASTM-1537) was studied to determine the range of cell viability and mode of cell death beyond the viable range. Cell viability and morphology, changes in actin cytoskeleton, adhesion complexes and nucleus, and mode of cell death (necrosis, or intrinsic or extrinsic apoptosis) were characterized at different voltages ranging from -1000 to +500 mV (Ag/AgCl). Moreover, electrochemical currents and metal ion concentrations at each voltage were measured and related to the observed responses. Results show that cathodic and anodic voltages outside the voltage viability range (-400 < V < +500) lead to primarily intrinsic apoptotic and necrotic cell death, respectively. Cell death is associated with cathodic current densities of 0.1 μA cm(-2) and anodic current densities of 10 μA cm(-2). Significant increase in metallic ions (Co, Cr, Ni, Mo) was seen at +500 mV, and -1000 mV (Cr only) compared to open circuit potential. The number and total projected area of adhesion complexes was also lower on the polarized alloy (p < 0.05). These results show that reduction reactions on CoCrMo alloys leads to apoptosis of cells on the surface and may be a relevant mode of cell death for metallic implants in-vivo. | Alloys, Animals, Apoptosis, Caspase 3, Caspase 9, Cell Adhesion, Cell Line, Cell Nucleus Size, Cell Shape, Cell Survival, Cobalt, Culture Media, Cytoskeleton, Electricity, Electrochemistry, Fluorescence, Ions, Mice, Models, Biological, Necrosis, Osteoblasts, Oxidation-Reduction, Vitallium | null |
22,704,845 | 2012-11-05 | 2022-03-30 | 1878-5905 | Biomaterials | Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release. | Pan Yuan-Jia, Chen Yuan-Yuan, Wang Dong-Rui, Wei Chuan, Guo Jia, Lu Da-Ru, Chu Chih-Chang, Wang Chang-Chun | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Biocompatible Materials, Cross-Linking Reagents, Delayed-Action Preparations, Disulfides, Hydrogels, Polymethacrylic Acids, polymethacrylic acid, Doxorubicin, Glutathione, Dithiothreitol | IM | 22704845, S0142-9612(12)00616-3, 10.1016/j.biomaterials.2012.05.062 | A new type of redox/pH dual stimuli-responsive poly(methacrylic acid) (PMAA)-based nanohydrogels was prepared from methacrylic acid and N,N-bis(acryloyl)cystamine crosslinker via distillation-precipitation polymerization. The nanohydrogels could be easily degraded into individual linear short chains (M(n) ≈ 1200, M(w)/M(n) < 1.1) in the presence of 10 mM dithiothreitol (DTT) or glutathione (GSH). Doxorubicin (DOX) as a model anti-cancer drug was high efficiently loaded into the nanohydrogels (up to 42.3 wt%) due to the strong electrostatic interactions between the amine group in doxorubicin (DOX) and the carboxyl groups in the nanohydrogels at a physiological pH. The cumulative release profile of the DOX-loaded nanohydrogels showed a low level of drug release (less than 15 wt% in 24 h) at pH 7.4, and was significantly accelerated at a lower pH (5.0) and reducing environment (over 91 wt% in 5 h), exhibiting an obvious pH/redox dual-responsive controlled drug release capability. The drug release behavior of the DOX-loaded nanohydrogels in the presence of GSH was very different from the DTT as the loaded DOX could be quickly released in the presence of GSH, but not in DTT. The possible reason is the synergic effect of reduction and charge exchange of GSH at a low pH. The dose-dependent cytotoxicity of the DOX-loaded nanohydrogels was studied by the CCK-8 assay; the DOX-loaded nanohydrogels could be taken up quickly by human glioma (U251MG cells) via endocytosis, and then biodegraded to release the loaded drugs, which exhibited a comparably anti-tumor efficacy. These nanohydrogels possess many favorable traits, such as excellent biocompatibility and biodegradability, adequate drug loading capacity, minimal drug release under an extracellular condition (non-reductive), and rapid drug release in response to the intracellular level of pH and reducing potential, which endow them as a promise candidate for delivering anti-cancer drugs. | Biocompatible Materials, Biodegradation, Environmental, Cell Line, Tumor, Cell Survival, Cross-Linking Reagents, Delayed-Action Preparations, Disulfides, Dithiothreitol, Doxorubicin, Glutathione, HEK293 Cells, Humans, Hydrogels, Hydrogen-Ion Concentration, Microscopy, Fluorescence, Microscopy, Phase-Contrast, Nanoparticles, Oxidation-Reduction, Polymethacrylic Acids, Spectroscopy, Fourier Transform Infrared | null |
22,704,846 | 2012-11-05 | 2018-12-01 | 1878-5905 | Biomaterials | Nanostructured PEG-based hydrogels with tunable physical properties for gene delivery to human mesenchymal stem cells. | Li Yan, Yang Chuan, Khan Majad, Liu Shaoqiong, Hedrick James L, Yang Yi-Yan, Ee Pui-Lai R | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Hydrogels, Micelles, Polycarboxylate Cement, Sulfones, Surface-Active Agents, polycarbonate, Polyethylene Glycols, divinyl sulfone, DNA, Luciferases | IM | 22704846, S0142-9612(12)00584-4, 10.1016/j.biomaterials.2012.05.043 | Effective delivery of DNA to direct cell behavior in a well defined three dimensional scaffold offers a superior approach in tissue engineering. In this study, we synthesized biodegradable nanostructured hydrogels with tunable physical properties for cell and gene delivery. The hydrogels were formed via Michael addition chemistry by reacting a four-arm acrylate-terminated PEG with a four-arm thiol-functionalized PEG. Nanosized micelles self-assembled from the amphiphilic PEG-b-polycarbonate diblock copolymer, having reactive end-groups, were chemically incorporated into the hydrogel networks at various contents. The use of Michael addition chemistry allows for in situ hydrogel formation under the physiological conditions. Mechanical property analysis of the hydrogels revealed a correlation between the content of micelles and the storage modulus of the hydrogels. Internal morphology of hydrogels was observed using a field emission scanning electron microscope, which showed that the number and/or size of the pores in the hydrogel increased with increasing micelle content due to reduced crosslinking degree. There exists an optimal micelle content for cell proliferation and gene transfection. MTT assays demonstrated the highest cell viability in the hydrogel with 20% micelles. The gene expression level in hMSCs in the hydrogel with 20% micelles was also significantly higher than that in the hydrogel without micelles. The enhanced cell viability and gene expression in the hydrogel with the optimized micelle content are likely attributed to the physical properties that provide a better environment for cell-matrix interactions. Therefore, incorporating micelles into the hydrogel is a good strategy to control cellular behavior in 3-D through changes in physical properties of the microenvironment. | Cell Death, Cell Survival, DNA, Elastic Modulus, Gene Transfer Techniques, Humans, Hydrogels, Luciferases, Magnetic Resonance Spectroscopy, Mesenchymal Stem Cells, Micelles, Nanostructures, Physical Phenomena, Polycarboxylate Cement, Polyethylene Glycols, Sulfones, Surface-Active Agents, Transfection | null |
22,704,847 | 2012-11-26 | 2015-11-19 | 1873-5487 | Archives of medical research | No effect of antidepressant treatment on elevated serum ceruloplasmin level in patients with first-episode depression: a longitudinal study. | Kaya Mehmet Cemal, Bez Yasin, Selek Salih, Fatih Karababa Ibrahim, Bulut Mahmut, Savaş Haluk A, Celik Hakim, Herken Hasan | eng | null | Journal Article | Antidepressive Agents, Biomarkers, Ceruloplasmin | IM | 22704847, S0188-4409(12)00131-2, 10.1016/j.arcmed.2012.05.006 | Ceruloplasmin, an acute phase reactant with antioxidant capacity, has been found to be increased in some psychiatric disorders like schizophrenia and obsessive compulsive disorder. However, studies in depression are very scarce. We undertook this study determine the serum ceruloplasmin levels of depressive patients before and after treatment, to compare them with those of healthy control subjects, and to assess any possible association of ceruloplasmin and treatment response. | Adult, Antidepressive Agents, Biomarkers, Ceruloplasmin, Depressive Disorder, Major, Female, Follow-Up Studies, Humans, Male, Middle Aged, Oxidative Stress, Severity of Illness Index, Treatment Outcome, Turkey, Young Adult | null |
22,704,848 | 2012-11-26 | 2018-12-17 | 1873-5487 | Archives of medical research | Effects of single nucleotide polymorphisms in K(ATP) channel genes on type 2 diabetes in a Turkish population. | Gonen Mustafa Sait, Arikoglu Hilal, Erkoc Kaya Dudu, Ozdemir Hulya, Ipekci Suleyman Hilmi, Arslan Ahmet, Kayis Seyit Ali, Gogebakan Bulent | eng | null | Journal Article, Research Support, Non-U.S. Gov't | ABCC8 protein, human, ATP-Binding Cassette Transporters, Insulin, Kir6.2 channel, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Sulfonylurea Receptors | IM | 22704848, S0188-4409(12)00156-7, 10.1016/j.arcmed.2012.06.001 | ATP-sensitive potassium (K(ATP)) channels of pancreatic β-cells play a key role in glucose-stimulated insulin secretion mechanism. The Kir6.2 protein, forming the K(ATP) channel pore inwardly, and the SUR1 protein that surrounds it forming the outside part of the channel were encoded by ABCC8 and KCNJ11 genes, respectively. Recent studies reported that the single nucleotide polymorphisms (SNPs) established in these genes are associated with defects in insulin secretion and type 2 diabetes mellitus (T2DM). We aimed to investigate the allele profiles and the risk alleles of the ABCC8 and KCNJ11 genes and to highlight the associations with the disease in patients in Konya region of Turkey where T2DM is common. | ATP-Binding Cassette Transporters, Adult, Aged, Aged, 80 and over, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Exons, Female, Genes, Dominant, Genes, Recessive, Genetic Predisposition to Disease, Genotype, Humans, Insulin, Insulin Resistance, Insulin Secretion, Male, Middle Aged, Polymorphism, Single Nucleotide, Potassium Channels, Inwardly Rectifying, Receptors, Drug, Sulfonylurea Receptors, Turkey | null |
22,704,849 | 2012-11-26 | 2022-12-07 | 1873-5487 | Archives of medical research | CYP3A5 polymorphism in Mexican renal transplant recipients and its association with tacrolimus dosing. | García-Roca Pilar, Medeiros Mara, Reyes Herlinda, Rodríguez-Espino Benjamín Antonio, Alberú Josefina, Ortiz Lourdes, Vásquez-Perdomo Mayela, Elizondo Guillermo, Morales-Buenrostro Luis Eduardo, Mancilla Urrea Eduardo, Castañeda-Hernández Gilberto | eng | null | Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't | Codon, Nonsense, Immunosuppressive Agents, Protein Isoforms, CYP3A5 protein, human, Cytochrome P-450 CYP3A, Tacrolimus | IM | 22704849, S0188-4409(12)00130-0, 10.1016/j.arcmed.2012.05.005 | Variability in CYP3A5 expression associated with differences in tacrolimus bioavailability has been documented. The wild-type allele CYP3A5*1 expresses the functional protein, whereas the CYP3A5*3 allele is a splice variant with a premature stop codon and encodes a truncated nonfunctional protein. The aim of the study was to determine the frequency of CYP3A5*1 and CYP3A5*3 in 291 (124 adults, 167 pediatric) Mexican renal transplant recipients, evaluate the tacrolimus dose requirements by genotype and compare genotype frequency data with that of other populations. | Adolescent, Adult, Alleles, Asian People, Biological Availability, Biotransformation, Black People, Child, Codon, Nonsense, Cross-Sectional Studies, Cytochrome P-450 CYP3A, Ethnicity, Female, Gene Frequency, Genotype, Humans, Immunosuppressive Agents, Kidney Transplantation, Male, Mexico, Phenotype, Polymorphism, Single Nucleotide, Protein Isoforms, Tacrolimus, White People, Young Adult | null |
22,704,850 | 2012-11-26 | 2016-11-25 | 1873-5487 | Archives of medical research | Vardenafil ameliorates calcium mobilization in pulmonary artery smooth muscle cells from hypoxic pulmonary hypertensive mice. | Chen Wen-Sheng, Li Xiao-Qiang, Cao Wei, Xiao Xiong, Dong Ling, Zhang Jin-Zhou | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Adrenergic alpha-Agonists, Calcium Channel Blockers, Calcium Channels, L-Type, Imidazoles, Inositol 1,4,5-Trisphosphate Receptors, Piperazines, Sulfones, Triazines, Vasodilator Agents, Phenylephrine, Vardenafil Dihydrochloride, Adenosine Triphosphate, Potassium, Calcium | IM | 22704850, S0188-4409(12)00129-4, 10.1016/j.arcmed.2012.05.004 | Vardenafil has been found to be potent in pulmonary hypertension; however, the underlying mechanisms remain poorly understood. To address this issue, we investigated the underlying mechanisms of vardenafil in the contribution of Ca(2+) signaling and mobilization in modifying vasoconstriction of pulmonary arteries in hypoxic mice. | Adenosine Triphosphate, Adrenergic alpha-Agonists, Animals, Calcium, Calcium Channel Blockers, Calcium Channels, L-Type, Calcium Signaling, Chronic Disease, Drug Evaluation, Preclinical, Hypertension, Pulmonary, Hypertrophy, Right Ventricular, Hypoxia, Imidazoles, Inositol 1,4,5-Trisphosphate Receptors, Ion Transport, Male, Mice, Mice, Inbred C57BL, Myocytes, Smooth Muscle, Patch-Clamp Techniques, Phenylephrine, Piperazines, Potassium, Sarcoplasmic Reticulum, Sulfones, Triazines, Vardenafil Dihydrochloride, Vasodilation, Vasodilator Agents | null |
22,704,851 | 2012-11-26 | 2018-12-01 | 1873-5487 | Archives of medical research | Role of ABCB1 C3435T in platinum-based therapy. | Pellegrino Paolo, Cattaneo Dario, Clementi Emilio | eng | null | Letter, Comment | ATP Binding Cassette Transporter, Subfamily B, Member 1, DNA-Binding Proteins, Endonucleases | IM | 22704851, S0188-4409(12)00159-2, 10.1016/j.arcmed.2012.06.004 | null | ATP Binding Cassette Transporter, Subfamily B, Member 1, Carcinoma, Non-Small-Cell Lung, DNA-Binding Proteins, Endonucleases, Humans, Lung Neoplasms, Polymorphism, Single Nucleotide | null |
22,704,852 | 2012-11-26 | 2022-03-10 | 1873-5487 | Archives of medical research | Effects of pulsed electromagnetic fields on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats. | Zhou Jun, He Hongchen, Yang Lin, Chen Shiju, Guo Hua, Xia Lu, Liu Huifang, Qin Yuxi, Liu Chuan, Wei Xiaofei, Zhou Yujing, He Chengqi | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Core Binding Factor Alpha 1 Subunit, Dkk1 protein, rat, Intercellular Signaling Peptides and Proteins, Low Density Lipoprotein Receptor-Related Protein-5, Lrp5 protein, rat, Runx2 protein, rat, Wnt3A Protein, Estradiol, Alkaline Phosphatase | IM | 22704852, S0188-4409(12)00157-9, 10.1016/j.arcmed.2012.06.002 | The therapeutic effects of pulsed electromagnetic fields (PEMFs) on osteoporosis have been documented. However, the precise mechanisms by which PEMFs elicit these favorable biological responses are still not fully understood. This study aimed to systematically investigate the effects of PEMFs on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats. | Absorptiometry, Photon, Alkaline Phosphatase, Animals, Bone Density, Core Binding Factor Alpha 1 Subunit, Disease Models, Animal, Electric Stimulation Therapy, Estradiol, Female, Femur, Gene Expression Regulation, Intercellular Signaling Peptides and Proteins, Low Density Lipoprotein Receptor-Related Protein-5, Lumbar Vertebrae, Magnetic Field Therapy, Ovariectomy, Random Allocation, Rats, Rats, Sprague-Dawley, Signal Transduction, Wnt Signaling Pathway, Wnt3A Protein | null |
22,704,854 | 2012-12-11 | 2022-03-31 | 1872-6623 | Pain | Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain. | Chu Larry F, D'Arcy Nicole, Brady Caitlin, Zamora Abigail Kathleen, Young Chelsea Anne, Kim Julie Eunwoo, Clemenson Anna Marie, Angst Martin S, Clark David J | eng | K23 GM071400 (NIGMS NIH HHS, United States); 5K23GM071400 (NIGMS NIH HHS, United States) | Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural | Delayed-Action Preparations, Morphine | IM | 22704854, 00006396-201208000-00011, 10.1016/j.pain.2012.02.028 | Although often successful in acute settings, long-term use of opioid pain medications may be accompanied by waning levels of analgesic response not readily attributable to advancing underlying disease, necessitating dose escalation to attain pain relief. Analgesic tolerance, and more recently opioid-induced hyperalgesia, have been invoked to explain such declines in opioid effectiveness over time. Because both phenomena result in inadequate analgesia, they are difficult to distinguish in a clinical setting. Patients with otherwise uncomplicated low-back pain were titrated to comfort or dose-limiting side effects in a prospective, randomized, double-blind, placebo-controlled clinical trial using sustained-release morphine or weight-matched placebo capsules for 1 month. A total of 103 patients completed the study, with an average end titration dose of 78 mg morphine/d. After 1 month, the morphine-treated patients developed tolerance to the analgesic effects of remifentanil, but did not develop opioid-induced hyperalgesia. On average, these patients experienced a 42% reduction in analgesic potency. The morphine-treated patients experienced clinically relevant improvements in pain relief, as shown by a 44% reduction in average visual analogue scale pain levels and a 31% improvement in functional ability. The differences in visual analogue scale pain levels (P = .003) and self-reported disability (P = .03) between both treatment groups were statistically significant. After 1 month of oral morphine therapy, patients with chronic low-back pain developed tolerance but not opioid-induced hyperalgesia. Improvements in pain and functional ability were observed. | Adolescent, Adult, Aged, Delayed-Action Preparations, Double-Blind Method, Drug Tolerance, Female, Humans, Hyperalgesia, Low Back Pain, Male, Middle Aged, Morphine, Opioid-Related Disorders, Pain Measurement, Placebo Effect, Treatment Outcome, Young Adult | null |
22,704,853 | 2012-12-11 | 2021-01-12 | 1872-6623 | Pain | An fMRI study on the acute effects of exercise on pain processing in trained athletes. | Scheef Lukas, Jankowski Jakob, Daamen Marcel, Weyer Gunther, Klingenberg Markus, Renner Julia, Mueckter Sara, Schürmann Britta, Musshoff Frank, Wagner Michael, Schild Hans H, Zimmer Andreas, Boecker Henning | eng | null | Journal Article | null | IM | 22704853, 00006396-201208000-00025, 10.1016/j.pain.2012.05.008 | Endurance exercise is known to promote sustained antinociceptive effects, and there is evidence that the reduction of pain perception mediated by exercise is driven by central opioidergic neurotransmission. To directly investigate the involved brain areas and the underlying neural mechanisms in humans, thermal heat-pain challenges were applied to 20 athletes during 4 separate functional magnetic resonance imaging (fMRI) scans, i.e., before and after 2 hours of running (exercise condition) and walking (control condition), respectively. Imaging revealed a reproducible pattern of distributed pain-related activation in all 4 conditions, including the mesial and lateral pain systems, and the periaqueductal gray (PAG) as a key region of the descending antinociceptive pathway. At the behavioral level, running as compared with walking decreased affective pain ratings. The influence of exercise on pain-related activation was reflected in a significant time × treatment interaction in the PAG, along with similar trends in the pregenual anterior cingulate cortex and the middle insular cortex, where pain-induced activation levels were elevated after walking, but decreased or unchanged after running. Our findings indicate that enhanced reactive recruitment of endogenous antinociceptive mechanisms after aversive repeated pain exposure is attenuated by exercise. The fact that running, but not walking, reproducibly elevated β-endorphin levels in plasma indicates involvement of the opioidergic system in exercise. This may argue for an elevated opioidergic tone in the brain of athletes, mediating antinociceptive mechanisms. Our findings provide the first evidence using functional imaging to support the role of endurance exercise in pain modulation. | Adaptation, Physiological, Adult, Brain, Exercise, Humans, Magnetic Resonance Imaging, Male, Pain Perception, Pain Threshold, Physical Endurance, Running | null |
22,704,855 | 2013-03-06 | 2021-01-12 | 1872-6623 | Pain | Food, pain, and drugs: does it matter what pain patients eat? | Bell Rae Frances, Borzan Jasenka, Kalso Eija, Simonnet Guy | eng | null | Journal Article, Review | Analgesics | IM | 22704855, 00006396-201210000-00006, 10.1016/j.pain.2012.05.018 | null | Analgesics, Diet Therapy, Dietary Supplements, Humans, Pain | null |
22,704,856 | 2012-12-11 | 2021-10-21 | 1872-6623 | Pain | Intermediate Charcot-Marie-Tooth disease due to a novel Trp101Stop myelin protein zero mutation associated with debilitating neuropathic pain. | Ramirez Juan D, Barnes Phillip R J, Mills Kerry R, Bennett David L H | eng | 083259 (Wellcome Trust, United Kingdom); 095698 (Wellcome Trust, United Kingdom) | Case Reports, Journal Article, Research Support, Non-U.S. Gov't | Genetic Markers, MPZ protein, human, Myelin P0 Protein | IM | 22704856, 00006396-201208000-00033, 10.1016/j.pain.2012.05.015, PMC3399778, UKMS49133, 18803325, 11160475, 17944871, 15824348, 22094129, 16519783, 17405136, 815515, 20626771, 16697110, 14871449, 16414078, 9097074, 15455439, 19882637, 11835311, 18940466, 1690568, 2483091, 16364956, 12545426, 9862301, 19259101, 16616847, 12112076, 18803324, 8816708, 12716929, 11157804, 11242114, 18003941, 14711881, 10839370, 18337304, 20850974, 10586278 | We report an English kindred affected across 4 generations with a hereditary neuropathy associated with debilitating neuropathic pain as the main clinical feature. The principal finding on clinical examination was sensory loss, and there was variable motor dysfunction. Electrophysiological studies revealed mild features of demyelination with median conduction velocity in the intermediate range. There was an autosomal-dominant pattern of inheritance, and genetic testing revealed a novel heterozygous Trp101X mutation in exon 3 coding for a portion of the extracellular domain of myelin protein zero. This is predicted to lead to premature termination of translation. Myelin protein zero is a key structural component of compact myelin, and over 100 mutations in this protein have been reported, which can give rise to neuropathies with either axonal, demyelinating, or intermediate features encompassing a wide range of severity. Chronic pain is an increasingly recognised sequela of certain hereditary neuropathies and may be musculoskeletal or neuropathic in origin. In this kindred, the neuropathy was relatively mild in severity, however, neuropathic pain was an important and disabling outcome. | Adolescent, Adult, Charcot-Marie-Tooth Disease, Female, Genetic Association Studies, Genetic Markers, Genetic Predisposition to Disease, Humans, Male, Mutation, Myelin P0 Protein, Neuralgia, Polymorphism, Single Nucleotide, Young Adult | null |
22,704,857 | 2013-09-03 | 2019-12-10 | 1532-2122 | European journal of oncology nursing : the official journal of European Oncology Nursing Society | Reach for recovery: evaluating a pilot study of a colorectal cancer survivorship programme. | Taylor Claire | eng | null | Evaluation Study, Journal Article | null | IM | 22704857, S1462-3889(12)00049-X, 10.1016/j.ejon.2012.05.002 | More people are living with and beyond a cancer diagnosis and new models of care are required which not only help cancer survivors meet their needs after cancer treatment but also offer guidance on how they might optimize their future quality of life. | Aftercare, Aged, Colorectal Neoplasms, Female, Humans, Male, Middle Aged, Pilot Projects, Program Evaluation, Quality of Life, Self-Help Groups, Surveys and Questionnaires, Survivors, United Kingdom | null |
22,704,861 | 2013-06-11 | 2012-08-28 | 1874-1754 | International journal of cardiology | Clinical definition of the axillary vein and experience with blind axillary puncture. | Jiang Meng, Mao Jia-liang, He Ben | eng | null | Letter, Research Support, Non-U.S. Gov't | null | IM | 22704861, S0167-5273(12)00736-X, 10.1016/j.ijcard.2012.05.089 | null | Axillary Vein, Catheterization, Peripheral, Humans, Phlebotomy | null |
22,704,860 | 2014-04-22 | 2018-12-02 | 1874-1754 | International journal of cardiology | The predictive value of C-reactive protein on recurrence of atrial fibrillation after cardioversion with or without treatment with atorvastatin. | Höglund Niklas, Andersson Jonas, Almroth Henrik, Tornvall Per, Englund Anders, Rosenqvist Mårten, Jensen Steen M, Boman Kurt | eng | null | Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial | Biomarkers, Heptanoic Acids, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pyrroles, C-Reactive Protein, Atorvastatin | IM | 22704860, S0167-5273(12)00717-6, 10.1016/j.ijcard.2012.05.071 | The aim of this study was to investigate whether high-sensitivity C-reactive protein (hsCRP) levels prior to cardioversion (CV) predict recurrence of atrial fibrillation (AF) in patients randomized to treatment with either atorvastatin or placebo 30 and 180 days after CV. | Aged, Atorvastatin, Atrial Fibrillation, Biomarkers, C-Reactive Protein, Double-Blind Method, Electric Countershock, Female, Follow-Up Studies, Heptanoic Acids, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Pyrroles, Recurrence, Treatment Outcome | Atorvastatin, Atrial fibrillation, C-reactive protein, Cardioversion |
22,704,862 | 2014-04-22 | 2022-03-18 | 1874-1754 | International journal of cardiology | Improved coronary artery blood flow following the correction of systolic dyssynchrony with cardiac resynchronization therapy. | Fang Fang, Chan Joseph Yat-Sun, Lee Alex Pui-Wai, Sung Shih-Hsien, Luo Xiu-Xia, Jiang Xin, Kwong Joey S W, Sanderson John E, Yu Cheuk-Man | eng | null | Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22704862, S0167-5273(12)00741-3, 10.1016/j.ijcard.2012.05.094 | Coronary blood flow (CBF) is improved by cardiac resynchronization therapy (CRT) and impaired by right ventricular apical (RVA) pacing in patients with heart failure. However, the underlying mechanism remains unclear. | Aged, Aged, 80 and over, Blood Flow Velocity, Cardiac Resynchronization Therapy, Cardiomyopathies, Coronary Circulation, Coronary Vessels, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Systole, Ultrasonography | BiV, CBF, CRT, Cardiac resynchronization therapy, Coronary blood flow, HF, LAD, Myocardial velocity, RVA, Systolic dyssynchrony, TDI, VTI, biventricular, cardiac resynchronization therapy, coronary blood flow, heart failure, left anterior descending coronary artery, right ventricular apical, tissue Doppler imaging, velocity–time integral |
22,704,863 | 2013-05-22 | 2012-07-16 | 1874-1754 | International journal of cardiology | Consumption of energy drinks: a new provocation test for primary arrhythmogenic diseases? | Gray Belinda, Das K Jipin, Semsarian Christopher | eng | null | Case Reports, Letter, Research Support, Non-U.S. Gov't | null | IM | 22704863, S0167-5273(12)00768-1, 10.1016/j.ijcard.2012.05.121 | null | Arrhythmias, Cardiac, Drinking, Energy Drinks, Energy Intake, Female, Humans, Male, Young Adult | null |
22,704,864 | 2013-06-06 | 2012-08-14 | 1874-1754 | International journal of cardiology | Impact of rate control during atrial fibrillation on the proarrhythmic and antiarrhythmic effects of biventricular pacing. | Gu Xiang, Zhu Ye, Sun Lei, Zhang Yi, Cao Kejiang, Cheng Jie | eng | null | Case Reports, Letter, Research Support, Non-U.S. Gov't | null | IM | 22704864, S0167-5273(12)00759-0, 10.1016/j.ijcard.2012.05.112 | null | Cardiac Resynchronization Therapy, Humans, Male, Middle Aged, Tachycardia, Ventricular, Treatment Outcome | null |
22,704,858 | 2012-11-05 | 2024-06-10 | 1090-2430 | Experimental neurology | Repetitive acute intermittent hypoxia increases expression of proteins associated with plasticity in the phrenic motor nucleus. | Satriotomo Irawan, Dale Erica A, Dahlberg Jenny M, Mitchell Gordon S | eng | R01 HL080209 (NHLBI NIH HHS, United States); HL69064 (NHLBI NIH HHS, United States); P01 NS057778 (NINDS NIH HHS, United States); R37 HL069064 (NHLBI NIH HHS, United States); HL007654 (NHLBI NIH HHS, United States); R01 HL069064 (NHLBI NIH HHS, United States); NS057778 (NINDS NIH HHS, United States); HL080209 (NHLBI NIH HHS, United States); T32 HL007654 (NHLBI NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural | Nerve Tissue Proteins | IM | 22704858, S0014-4886(12)00231-2, 10.1016/j.expneurol.2012.05.020, PMC4375014, NIHMS668950, 16893610, 11438615, 14551171, 15509618, 17126615, 15716627, 10749120, 14579249, 18230673, 19805745, 18305238, 10438538, 19416672, 10540002, 10616905, 12486024, 17451658, 10531470, 9120052, 21302291, 12122082, 17293169, 22403346, 19449238, 21585327, 11238953, 19210478, 21613481, 21821826, 17374610, 15229096, 9710040, 17412505, 11264318, 20217354, 9345014, 12819226, 16597699, 11299296, 19237427, 11852072, 9287359, 16820027, 16902997, 15678129, 12598679, 17099064, 22423083, 10484481, 12823460, 18692605, 21242254, 12684486, 7276259, 8893371, 10102504, 14699417, 20525723, 9763486, 15207349, 12773326, 14622195, 21292044, 11356815, 18337426, 8978681, 8909453, 19664708, 15772352, 19559048, 16036433, 21470581, 21223996, 6452673, 16963562, 16740642 | Acute intermittent hypoxia (AIH) initiates plasticity in respiratory motor control, including phrenic long term facilitation (pLTF). Since pLTF is enhanced by preconditioning with repetitive exposure to AIH (rAIH), we hypothesized that a rAIH protocol consisting of 3 AIH exposures per week for 10 weeks (3×wAIH; AIH: 10, 5-min episodes of 10.5% O(2); 5-min normoxic intervals) would enhance expression of molecules that play key roles in pLTF within the phrenic motor nucleus. Immunohistochemical analyses revealed that 3×wAIH for 10 weeks increased serotonin terminal density in the C4 phrenic motor nucleus and serotonin 2A (5-HT(2A)) receptor expression in presumptive phrenic motor neurons. Immunoreactive brain derived neurotrophic factor (BDNF) and its high affinity receptor (TrkB) also increased following 3×wAIH. 3×wAIH also increased expression of another hypoxia-sensitive growth factor known to elicit phrenic motor facilitation, vascular endothelial growth factor (VEGF), and its receptor (VEGFR-2). Kinases "downstream" from TrkB and VEGFR-2 were up-regulated in or near presumptive phrenic motor neurons, including phosphorylated extracellular-signal regulated kinase (p-ERK) and protein kinase B (p-AKT). Thus, 3×wAIH up-regulates neurochemicals known to be associated with phrenic motor plasticity. Since 3×wAIH upregulates pro-plasticity molecules without evidence for CNS pathology, it may be a useful therapeutic tool in treating disorders that cause respiratory insufficiency, such as spinal injury or motor neuron disease. | Acute Disease, Animals, Apoptosis, Gliosis, Hypoxia, Male, Nerve Tissue Proteins, Neuronal Plasticity, Phrenic Nerve, Random Allocation, Rats, Rats, Sprague-Dawley, Time Factors, Up-Regulation | null |
22,704,865 | 2013-07-08 | 2012-12-04 | 1874-1754 | International journal of cardiology | The value of coronary calcium score in daily clinical routine, a case series of patients with extensive coronary calcifications. | Ghadri Jelena-R, Fiechter Michael, Fuchs Tobias A, Templin Christian, Lüscher Thomas F, Kaufmann Philipp A | eng | null | Case Reports, Letter, Research Support, Non-U.S. Gov't | null | IM | 22704865, S0167-5273(12)00682-1, 10.1016/j.ijcard.2012.05.068 | null | Aged, Coronary Angiography, Coronary Vessels, Electrocardiography, Female, Humans, Male, Middle Aged, Myocardial Perfusion Imaging, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Vascular Calcification | null |
22,704,867 | 2014-04-22 | 2020-12-16 | 1874-1754 | International journal of cardiology | Left ventricular non-compaction: prevalence in congenital heart disease. | Stähli Barbara E, Gebhard Catherine, Biaggi Patric, Klaassen Sabine, Valsangiacomo Buechel Emanuela, Attenhofer Jost Christine H, Jenni Rolf, Tanner Felix C, Greutmann Matthias | eng | null | Journal Article | null | IM | 22704867, S0167-5273(12)00742-5, 10.1016/j.ijcard.2012.05.095 | Left ventricular non-compaction cardiomyopathy (LVNC) is a rare cardiomyopathy, originally described as an isolated disease without other structural cardiac abnormalities. The aim of this study was to explore the prevalence of LVNC among adults with different types of congenital heart disease. | Adult, Female, Follow-Up Studies, Heart Defects, Congenital, Humans, Male, Prevalence, Ultrasonography, Young Adult | Cardiomyopathy, Congenital heart disease, Echocardiography, Left ventricular non‐compaction |
22,704,866 | 2014-04-22 | 2018-12-02 | 1874-1754 | International journal of cardiology | Efficacy and safety of intensified antiplatelet therapy on the basis of platelet reactivity testing in patients after percutaneous coronary intervention: systematic review and meta-analysis. | Aradi Dániel, Komócsi András, Price Matthew J, Cuisset Thomas, Ari Hasan, Hazarbasanov Dobri, Trenk Dietmar, Sibbing Dirk, Valgimigli Marco, Bonello Laurent | eng | null | Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review | Platelet Aggregation Inhibitors | IM | 22704866, S0167-5273(12)00747-4, 10.1016/j.ijcard.2012.05.100 | ADP-specific platelet function assays were shown to predict thrombotic events, and might be helpful to select candidates for more potent antiplatelet therapy. We aimed to determine the efficacy and safety of giving intensified antiplatelet therapy on the basis of platelet reactivity testing for patients undergoing percutaneous coronary intervention (PCI). | Humans, Percutaneous Coronary Intervention, Platelet Activation, Platelet Aggregation Inhibitors, Platelet Function Tests, Randomized Controlled Trials as Topic, Thrombosis, Treatment Outcome | Bleeding, Clinical outcome, Clopidogrel, High platelet reactivity, Platelet function testing |
22,704,868 | 2014-04-22 | 2022-03-10 | 1874-1754 | International journal of cardiology | Angina and intermittent claudication in 7403 participants of the 2003 Scottish Health Survey: impact on general and mental health, quality of life and five-year mortality. | Inglis Sally C, Lewsey James D, Lowe Gordon D O, Jhund Pardeep, Gillies Michelle, Stewart Simon, Capewell Simon, Macintyre Kate, McMurray John J V | eng | G0900847 (Medical Research Council, United Kingdom) | Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | null | IM | 22704868, S0167-5273(12)00746-2, 10.1016/j.ijcard.2012.05.099 | Angina and intermittent claudication impair function and mobility and reduce health-related quality of life. Both symptoms have similar etiology, yet the physical and psychological impacts of these symptoms are rarely studied in community-based cohorts or in individuals with isolated symptoms. | Adolescent, Adult, Aged, Aged, 80 and over, Angina Pectoris, Cohort Studies, Cross-Sectional Studies, Female, Health Status, Health Surveys, Humans, Intermittent Claudication, Male, Mental Health, Middle Aged, Quality of Life, Scotland, Survival Rate, Young Adult | Angina, Claudication, Morbidity, Mortality, Quality of life |
22,704,869 | 2013-10-22 | 2022-12-07 | 1874-1754 | International journal of cardiology | Spontaneous dissection of Valsalva sinus complicated by fistula from aorta to left ventricle through ventricular septum in a patient with Behçet's disease. | Dong Lili, Wang Yongshi, Yao Haohua, Sun Minmin, Kong Dehong, Pan Cuizhen, Shu Xianhong | eng | null | Case Reports, Letter, Research Support, Non-U.S. Gov't | null | IM | 22704869, S0167-5273(12)00766-8, 10.1016/j.ijcard.2012.05.119 | null | Adult, Aortic Dissection, Aorta, Aortic Aneurysm, Behcet Syndrome, Heart Ventricles, Humans, Male, Sinus of Valsalva, Vascular Fistula, Ventricular Septum | null |
22,704,870 | 2013-06-06 | 2012-09-03 | 1874-1754 | International journal of cardiology | Successful treatment of adult patients with idiopathic recurrent pericarditis with an interleukin-1 receptor antagonist (anakinra). | Vassilopoulos Dimitrios, Lazaros George, Tsioufis Costas, Vasileiou Panagiotis, Stefanadis Christodoulos, Pectasides Dimitrios | eng | null | Case Reports, Letter | Antirheumatic Agents, Interleukin 1 Receptor Antagonist Protein | IM | 22704870, S0167-5273(12)00733-4, 10.1016/j.ijcard.2012.05.086 | null | Adult, Antirheumatic Agents, Female, Humans, Interleukin 1 Receptor Antagonist Protein, Male, Pericarditis, Recurrence | null |
22,704,871 | 2013-06-11 | 2018-12-01 | 1874-1754 | International journal of cardiology | Macrophage/monocyte activation and cardiovascular disease. | Dominguez-Rodriguez Alberto, Abreu-Gonzalez Pedro, Avanzas Pablo | eng | null | Letter, Comment | null | IM | 22704871, S0167-5273(12)00735-8, 10.1016/j.ijcard.2012.05.088 | null | Animals, Cardiovascular Diseases, Humans | null |
22,704,872 | 2014-04-22 | 2021-10-21 | 1874-1754 | International journal of cardiology | Long-chain, n-3 fatty acids and physical activity--independent and interactive associations with cardiac autonomic control. | Harbaugh Matthew P, Manuck Stephen B, Jennings J Richard, Conklin Sarah M, Yao Jeffrey K, Muldoon Matthew F | eng | T32 HL07560 (NHLBI NIH HHS, United States); T32 HL007560 (NHLBI NIH HHS, United States); R21 HL081282 (NHLBI NIH HHS, United States); P01 HL40962 (NHLBI NIH HHS, United States); P01 HL040962 (NHLBI NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural | Fatty Acids, Omega-3 | IM | 22704872, S0167-5273(12)00757-7, 10.1016/j.ijcard.2012.05.110, PMC3484192, NIHMS390124, 16616012, 8727647, 9424039, 19034030, 17768297, 17980217, 9756580, 17381425, 21753804, 20713909, 11867059, 707484, 18328835, 12814244, 8941112, 8353919, 17045894, 18513505, 16172267, 18285566, 8737210, 3812275, 18514313, 1728446, 19684184, 20548976, 17089085, 7841134, 2606116, 7823386, 3945246, 18339222, 17398308, 10479194, 10465168, 8426621, 15925295, 15220949, 17942470, 20452573, 12162948, 10446081 | Intake of the marine-based, n-3 fatty acids and engagement in physical activity are inversely related to cardiac morbidity and mortality. Among putative mechanisms, both n-3 fatty acids and physical activity may act through modulation of autonomic control of the cardiovascular system. This investigation examined the independent and interactive associations of n-3 fatty acids (eicosapentaenoic and docosahexanenoic acid; EPA, DHA) and physical activity with heart rate variability (HRV). | Adult, Autonomic Nervous System, Blood Pressure, Cross-Sectional Studies, Fatty Acids, Omega-3, Female, Heart Diseases, Heart Rate, Humans, Male, Middle Aged, Motor Activity | Exercise, HRV, n-3 fatty acids |
22,704,873 | 2014-03-03 | 2013-06-04 | 1874-1754 | International journal of cardiology | Mucopolysaccharidosis type VI: a cardiologist's guide to diagnosis and treatment. | Golda Adam, Jurecka Agnieszka, Opoka-Winiarska Violetta, Tylki-Szymańska Anna | eng | null | Journal Article, Review | null | IM | 22704873, S0167-5273(12)00762-0, 10.1016/j.ijcard.2012.05.115 | Mucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome) is an inborn error of metabolism, with incidences at birth ranging from 1 in 1.5 million to 1 in 43,000 live births. This disorder is rarely considered when evaluating patients with common populational cardiovascular diseases. A significant number of MPS VI patients, however, do present cardiovascular disease and MPS VI should be considered as a potential differential diagnosis for other cardiovascular disorders. This article reviews the clinical features, diagnostic tests and treatment options for MPS VI. Although MPS VI affects many organs and systems of the human body this review focuses on MPS VI diseases of the heart and vessels. The most characteristic cardiac presentation of MPS VI is valvular disease, but heart failure, pulmonary hypertension, cardiomyopathy, fibroelastosis and cardiac conduction system disorders may also occur. Cardiovascular disease in MPS VI patients may emerge silently. An early diagnosis is difficult due to joint stiffness, respiratory system involvement or skeletal malformations that limit exercise capacity and mask the underlining heart failure. This article is supposed to serve as a very practical reference for cardiologists who may come across MPS VI in their daily practices. A greater awareness of cardiovascular manifestations of MPS VI among cardiologists can help to reduce misdiagnosis and promote early detection of this inborn disorder and aid the implementation of adequate therapy at the earliest stage possible which is crucial for its efficacy. | Cardiology, Cardiovascular Diseases, Humans, Mucopolysaccharidosis VI, Physicians, Practice Guidelines as Topic, Treatment Outcome | null |
22,704,874 | 2013-01-28 | 2014-11-20 | 1874-1754 | International journal of cardiology | The most vulnerable large atrial arteries during surgery and radiofrequency ablation of the pulmonary veins. | Nerantzis Christos E, Anninos Hector, Couvaris Constantinos M | eng | null | Letter | null | IM | 22704874, S0167-5273(12)00722-X, 10.1016/j.ijcard.2012.05.075 | null | Adult, Arteries, Catheter Ablation, Female, Heart Atria, Humans, In Vitro Techniques, Male, Pulmonary Veins, Risk Factors | null |
22,704,875 | 2013-06-06 | 2018-12-01 | 1874-1754 | International journal of cardiology | Caution in interpreting the findings from small observational studies. | Navarese Eliano Pio, Gurbel Paul, Tantry Udaya, Obonska Karolina, Sukiennik Adam, Kubica Jacek | eng | null | Letter, Comment | Polymers, Sirolimus | IM | 22704875, S0167-5273(12)00731-0, 10.1016/j.ijcard.2012.05.084 | null | Absorbable Implants, Angioplasty, Balloon, Coronary, Drug-Eluting Stents, Female, Humans, Male, Myocardial Infarction, Polymers, Sirolimus | null |
22,704,876 | 2014-04-22 | 2015-11-19 | 1874-1754 | International journal of cardiology | Osteoprotegerin in ST-elevation myocardial infarction: prognostic impact and association with markers of myocardial damage by magnetic resonance imaging. | Fuernau Georg, Zaehringer Sebastian, Eitel Ingo, de Waha Suzanne, Droppa Michal, Desch Steffen, Schuler Gerhard, Adams Volker, Thiele Holger | eng | null | Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't | Biomarkers, Osteoprotegerin | IM | 22704876, S0167-5273(12)00748-6, 10.1016/j.ijcard.2012.05.101 | For osteoprotegerin (OPG), a cytokine of the tumor necrosis factor superfamily, the prognostic impact in stable coronary artery disease and acute coronary syndromes has been shown recently. In acute ST-elevation myocardial infarction (STEMI) data on the correlation to myocardial damage by cardiac magnetic resonance imaging (CMR) or clinical outcome are lacking. | Aged, Aged, 80 and over, Biomarkers, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Myocardial Infarction, Myocardium, Osteoprotegerin, Percutaneous Coronary Intervention, Prognosis | AAR, CI, CMR, HR, IS, LV, MACE, MO, MSI, Magnetic resonance imaging, Myocardial infarction, OPG, Osteoprotegerin, Prognosis, Reperfusion, SPECT, ST-elevation myocardial infarction, STEMI, TIMI, Thrombolysis In Myocardial Infarction, area at risk, cardiac magnetic resonance imaging, confidence interval, hazard ratio, infarct size, left ventricular, major adverse cardiovascular events, microvascular obstruction, myocardial salvage index, osteoprotegerin, single photon emission tomography |
22,704,877 | 2014-04-22 | 2022-12-07 | 1874-1754 | International journal of cardiology | Aggressive and diffuse coronary calcification in South Asian angina patients compared to Caucasians with similar risk factors. | Koulaouzidis G, Nicoll R, Charisopoulou D, McArthur T, Jenkins P J, Henein M Y | eng | null | Comparative Study, Journal Article | null | IM | 22704877, S0167-5273(12)00749-8, 10.1016/j.ijcard.2012.05.102 | Ethnic differences in prevalence and severity of coronary artery disease are well established and are usually attributed to risk factors variation. This study investigates the differences in coronary artery narrowing and coronary calcification between two age- and gender-matched cohorts of South Asian and Caucasian symptomatic angina patients. | Aged, Angina Pectoris, Asian People, Cohort Studies, Coronary Artery Disease, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Severity of Illness Index, Vascular Calcification, White People | Atherosclerosis risk factors, Coronary CT scanning, Coronary artery calcification, South Asians |
22,704,878 | 2013-06-06 | 2012-08-14 | 1874-1754 | International journal of cardiology | Autophagy downregulates thrombin-induced VSMCs proliferation through lysosomal pathway. | Dong Nan, Zhu Qian, Zhang Peipei, Zhu Chunfang, Wang MinChen, Li Wenjie, Liu Juan, Liu YanMei, Ma Bin, Wu Kaiyun | eng | null | Letter, Research Support, Non-U.S. Gov't | Thrombin | IM | 22704878, S0167-5273(12)00616-X, 10.1016/j.ijcard.2012.05.005 | null | Animals, Aorta, Abdominal, Autophagy, Cell Proliferation, Cells, Cultured, Down-Regulation, Lysosomes, Muscle, Smooth, Vascular, Rats, Rats, Sprague-Dawley, Signal Transduction, Thrombin | null |
22,704,879 | 2012-11-01 | 2015-11-19 | 1873-4162 | Legal medicine (Tokyo, Japan) | High concentration of methidathion detected in a fatal case of organophosphate-poisoning. | Takayasu Tatsunori, Ishida Yuko, Nosaka Mizuho, Kawaguchi Mariko, Kuninaka Yumi, Kimura Akihiko, Kondo Toshikazu | eng | null | Case Reports, Journal Article | Insecticides, Organothiophosphorus Compounds, Xylenes, methidathion | IM | 22704879, S1344-6223(12)00076-4, 10.1016/j.legalmed.2012.04.007 | We report a case of fatal intoxication caused by the ingestion of an organophosphate pesticide, methidathion (DMTP). An 80-year-old male was found dead in his bed. Forensic autopsy revealed no remarkable morphological changes. However, in a toxicological screening test, methidathion was qualitatively detected in extracts of stomach contents. Concentrations of methidathion (μg/g) in body fluids and organ tissues, determined by gas chromatography-mass spectrometry, were as follows; 66.2 in heart blood, 8.33 in peripheral blood, 8.80 in urine, 2000 in the brain (frontal lobe), 4800 in the left lung, 810 in the liver, 150 in the left kidney, and 64,000 in the stomach contents (total 1.9 g). These results strongly suggested that the victim orally ingested methidathion. Additionally, xylene was determined in body fluids and organ tissues. From the toxicological data together with autopsy findings, the cause of his death was diagnosed as acute poisoning by an emulsion of methidathion. | Aged, 80 and over, Autopsy, Body Fluids, Cause of Death, Eating, Forensic Toxicology, Gastrointestinal Contents, Humans, Insecticides, Male, Organothiophosphorus Compounds, Xylenes | null |
22,704,880 | 2012-09-24 | 2019-12-10 | 1873-3778 | Journal of chromatography. A | Selective electromembrane extraction at low voltages based on analyte polarity and charge. | Domínguez Noelia Cabaleiro, Gjelstad Astrid, Nadal Andrea Molina, Jensen Henrik, Petersen Nickolaj Jacob, Hansen Steen Honoré, Rasmussen Knut Einar, Pedersen-Bjergaard Stig | eng | null | Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't | 2-nitrophenyl octyl ether, Ethers, Membranes, Artificial, Pharmaceutical Preparations | IM | 22704880, S0021-9673(12)00841-2, 10.1016/j.chroma.2012.05.092 | Electromembrane extraction (EME) at low voltage (0-15 V) of 29 different basic model drug substances was investigated. The drug substances with logP<2.3 were not extracted at voltages less than 15 V. Extraction of drug substances with logP≥2.3 and with two basic groups were also effectively suppressed by the SLM at voltages less than 15 V. Drug substances with logP≥2.3 and with one basic group were all extracted at low voltages and with a strong compound selectivity which appeared to have some influence from the polar surface area of the compound. For this group of substances, recoveries varied between 0 and 23% at 5 V, whereas, recoveries varied between 5.5 and 51% at 15 V. Based on mass transfer differences related to charge, polarity, and polar surface, highly selective extractions of drug substances were demonstrated from human plasma, urine, and breast milk. An initial evaluation at low voltage (5 V) was compared with similar extractions at a more normal voltage level (50 V), and this supported that reliable data can be obtained under these low-voltage (mild) conditions by EME. | Animals, Chemical Fractionation, Electrochemical Techniques, Electrodes, Electrophoresis, Capillary, Equipment Design, Ethers, Humans, Membranes, Artificial, Milk, Pharmaceutical Preparations, Sensitivity and Specificity | null |
22,704,881 | 2012-10-29 | 2013-11-21 | 1873-3778 | Journal of chromatography. A | Design of preparative-supercritical fluid chromatography. | Rajendran Arvind | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Review | Carbon Dioxide | IM | 22704881, S0021-9673(12)00754-6, 10.1016/j.chroma.2012.05.037 | Preparative supercritical fluid chromatography (prep-SFC) is an important separation process in the chromatographers toolbox. Owing to the unique properties of the mobile phase, which is predominantly CO(2), the behavior of SFC is markedly different from high performance liquid chromatography (HPLC). This review article focuses on the scale-up of preparative chromatography. The basics of SFC, with particular focus on highlighting the key differences between SFC and HPLC, are introduced. Then, a framework for rational design of prep-SFC is proposed. This framework is based on obtaining basic system parameters from analytical scale equipment, i.e., with very small amount of material, and performing design and optimization in silico to evaluate process performance and to identify operating conditions for scale-up. The tools required to obtain the input parameters such as adsorption isotherms are discussed and the development of the design and optimization framework is elaborated. Examples from the literature which use this approach for successful scale-up are provided. Finally the design of multi-column SFC systems is discussed. | Adsorption, Carbon Dioxide, Chromatography, Supercritical Fluid, Pressure, Temperature | null |
22,704,882 | 2012-09-24 | 2019-12-10 | 1873-3778 | Journal of chromatography. A | Optimisation of ultrasound-assisted emulsification microextraction method with solidification of floating organic drop for the analysis of cork taint responsible compounds in wine. | Pizarro C, Sáenz-González C, Pérez-del-Notario N, González-Sáiz J M | eng | null | Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't | Anisoles, Emulsions, Phenols, 2,4,6-tribromoanisole | IM | 22704882, S0021-9673(12)00850-3, 10.1016/j.chroma.2012.05.100 | This paper presents the optimisation of a method based on ultrasound assisted-emulsification method (USAEME) combined with solidification of floating organic drop (SFOD) for the sensitive determination of cork taint responsible compounds in wine. Haloanisoles (2,4,6-trichloranisole (TCA), 2,3,4,6-tetrachloroanisole (TeCA), 2,4,6-tribromoanisole (TBA) and pentachloranisole (PCA)) and their halophenolic precursors were determined by gas chromatography with electron capture detection (GC-ECD). The derivatisation of the halophenols was performed simultaneously with the extraction. To perform the optimisation, the main parameters affecting both extraction and derivatisation were exhaustively studied in different steps. Once the extraction solvent and the pH and time conditions had been determined, experimental design was applied for the simultaneous study of the volumes of acetic anhydride and extraction solvent, temperature and ionic strength conditions. Then, the analytical characteristics of the optimised method were evaluated achieving satisfactory linearity (with correlation coefficients over 0.984), repeatability (below 10.7%) and inter-day precision (below 10.6%) for all target analytes. Moreover, detection limits found were similar or even lower than the olfactory threshold of the studied compounds. Finally, the applicability of the proposed method was tested by analysing real wine samples. To the best of our knowledge, this is the first time that USAEME-SFOD method has been used to determine cork taint responsible compounds in wine. | Anisoles, Chemical Fractionation, Emulsions, Gas Chromatography-Mass Spectrometry, Phenols, Sensitivity and Specificity, Ultrasonics, Wine | null |
22,704,883 | 2012-09-24 | 2019-12-10 | 1873-3778 | Journal of chromatography. A | Molecularly imprinted-solid phase extraction combined with simultaneous derivatization and dispersive liquid-liquid microextraction for selective extraction and preconcentration of methamphetamine and ecstasy from urine samples followed by gas chromatography. | Djozan Djavanshir, Farajzadeh Mir Ali, Sorouraddin Saeed Mohammad, Baheri Tahmineh | eng | null | Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't | Central Nervous System Agents, Methamphetamine, N-Methyl-3,4-methylenedioxyamphetamine | IM | 22704883, S0021-9673(12)00817-5, 10.1016/j.chroma.2012.05.085 | In this study, a developed technique was reported for extraction and pre-concentration of methamphetamine (MAMP) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) from urine samples using molecularly imprinted-solid phase extraction (MISPE) along with simultaneous derivatization and dispersive liquid-liquid microextraction (DLLME). Molecularly imprinted microspheres as sorbent in solid phase extraction (SPE) procedure were synthesized using precipitation polymerization with MAMP as the template. Aqueous solution of the target analytes was passed through MAMP-MIP cartridge and the adsorbed analytes were then eluted with methanol. The collected eluate was mixed with butylchloroformate which served as the derivatization reagent as well as the extraction solvent. The mixture was immediately injected into deionized water. After centrifugation, 1 μL of the settled organic phase was injected into gas chromatography-flame ionization detection (GC-FID) or gas chromatography-mass spectrometry (GC-MS). Various experimental parameters affecting the performance of both of the steps (MISPE and DLLME) were thoroughly investigated. The calibration graphs were linear in the ranges of 10-1500 ng mL(-1) (MAMP) and 50-1500 ng mL(-1) (MDMA), and the detection limits (LODs) were 2 and 18 ng mL(-1), respectively. The relative standard deviations (%RSDs) obtained for six repeated experiments (100 ng mL(-1) of each drug) were 5.1% and 6.8% for MAMP and MDMA, respectively. The relative recoveries obtained for the analytes in human urine samples, spiked with different levels of each drug, were within the range of 80-88%. | Calibration, Central Nervous System Agents, Chromatography, Gas, Flame Ionization, Humans, Limit of Detection, Liquid Phase Microextraction, Methamphetamine, Molecular Imprinting, N-Methyl-3,4-methylenedioxyamphetamine, Solid Phase Extraction, Substance Abuse Detection | null |
22,704,884 | 2012-09-04 | 2018-12-01 | 1873-3778 | Journal of chromatography. A | A study of the thermodynamics of retention of block (co)oligomers using high-performance liquid chromatography/mass spectrometry. | Ceslová Lenka, Jandera Pavel, Cesla Petr | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Epoxy Compounds, Polyethylene Glycols, Ethylene Oxide, propylene oxide | IM | 22704884, S0021-9673(12)00808-4, 10.1016/j.chroma.2012.05.076 | Chromatographic behavior of block (co)oligomers of oxyethylene (EO) and oxypropylene (PO) surfactants in reversed-phase HPLC (RP-HPLC) was investigated. The retention of EO/PO block (co)oligomers depends on the distribution of the individual monomer repeat units, but the sequence of the individual blocks also plays a (less significant) role. The enthalpic and entropic contributions of the EO and PO repeat units to the retention were determined from the data measured at changing temperature. In RP-HPLC, the effect of the repeat PO units on separation is higher than the influence of the repeat EO units. In addition to the enthalpic contributions, the retention is significantly influenced by the entropy (possibly by the change of conformation and solvation of adsorbed molecules); dual molar mass distribution according to the number of EO and PO units complicates correct assignment of the chromatographic peaks to the individual (co)oligomers in complex samples based only on the chromatographic retention data. In spite of imperfect chromatographic separation, HPLC coupled with positive ion mode atmospheric pressure chemical ionization mass spectrometry allow identifying unambiguously the dual monomer distribution in the samples of EO-PO block (co)oligomers. | Chromatography, High Pressure Liquid, Epoxy Compounds, Ethylene Oxide, Mass Spectrometry, Polyethylene Glycols, Thermodynamics | null |
22,704,885 | 2013-01-07 | 2012-09-19 | 1873-3778 | Journal of chromatography. A | Electrochemistry coupled to (liquid chromatography/) mass spectrometry--current state and future perspectives. | Jahn Sandra, Karst Uwe | eng | null | Journal Article, Review | Peptides, Proteins, DNA | IM | 22704885, S0021-9673(12)00798-4, 10.1016/j.chroma.2012.05.066 | The coupling of electrochemistry (EC) to different mass spectrometric (MS) techniques in off-line and especially in on-line approaches is a quickly growing research field in analytical chemistry with numerous distinct objectives. Depending on the analytical problem, a separation step can be further integrated according to the instrumental set-up and, most frequently, liquid chromatography (LC) is selected for this purpose. In this review, various scientific areas of application for this EC/(LC/)MS hybrid method are presented and discussed in detail. Therefore, one major division is made between those applications which are already successfully used on a large scale (current state), and those which have shown promising results for future utilization (future perspectives). The reader shall be provided with a thorough overview on the capabilities of the combination of EC/(LC/)MS and the drawbacks which result in further optimization and exploration of this technique. The major topics addressed in this review include the role of EC/(LC/)MS for drug metabolism studies, peptide, protein and DNA (deoxyribonucleic acid) research and quantification strategies. Promising future applications that are presented and evaluated comprise the fields of toxicology and forensics, targeted product synthesis and environmental analysis. | Animals, Chromatography, Liquid, DNA, Electrochemical Techniques, Humans, Mass Spectrometry, Peptides, Proteins | null |
22,704,886 | 2013-01-04 | 2018-12-01 | 1464-3405 | Bioorganic & medicinal chemistry letters | Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment. | Kim Dong-Hwan, Hong Bin Na, Le Hoa Thi, Hong Ha Na, Lim Choon Woo, Park Keun Ha, Kim Tae Woo, Kang Tong Ho | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Polyethylene Glycols, Diosgenin | IM | 22704886, S0960-894X(12)00706-8, 10.1016/j.bmcl.2012.05.094 | Diosgenin was modified to control its in vivo bioavailability by conjugating a hydrophilic unit, tetraethylene glycol. The diosgenin-tetraethylene glycol conjugate (TE) was orally administered in streptozotocin induced diabetic mice for this auditory protection study. The bioactivity improvement of TE for in vivo diabetic auditory impairment treatment was clearly observed in three different auditory tests and compared with that of diosgenin. The improvement in in vivo efficacy suggests that the small molecular weight PEGylation of diosgenin is a synthetically robust and systematically applicable strategy to reform the poor pharmacokinetics of a hydrophobic aglycone. | Animals, Diabetes Mellitus, Experimental, Diosgenin, Molecular Structure, Molecular Weight, Polyethylene Glycols | null |
22,704,887 | 2013-01-04 | 2024-03-23 | 1464-3405 | Bioorganic & medicinal chemistry letters | Synthesis and evaluation of novel potent HCV NS5A inhibitors. | Zhang Hongwang, Zhou Longhu, Amblard Franck, Shi Junxing, Bobeck Drew R, Tao Sijia, McBrayer Tamara R, Tharnish Phillip M, Whitaker Tony, Coats Steven J, Schinazi Raymond F | eng | P30 AI050409 (NIAID NIH HHS, United States); R01 AI071846 (NIAID NIH HHS, United States); 5R01-AI-071846 (NIAID NIH HHS, United States); 5P30-AI-50409 (NIAID NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S. | Antiviral Agents | IM | 22704887, S0960-894X(12)00642-7, 10.1016/j.bmcl.2012.05.039, PMC3389222, NIHMS380374, 11118372, 10208859, 20410884, 19737023, 17692525, 20309487, 20585111, 19812153, 20040045, 21747363, 21041908 | Judicious modifications to the structure of the previously reported HCV NS5A inhibitor 1, resulted in more potent anti-HCV compounds with similar and in some cases improved toxicity profiles. The synthesis of 19 new NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. For the most potent compounds chemical stability, stability in liver microsomes and inhibition of relevant CYP450 enzymes is also presented. | Antiviral Agents, Cell Line, Tumor, Cell Survival, Hepacivirus, Humans, Microsomes, Liver, Molecular Structure, Structure-Activity Relationship | null |
22,704,888 | 2013-01-04 | 2013-11-21 | 1464-3405 | Bioorganic & medicinal chemistry letters | Total synthesis and antifungal activity of (2S,3R)-2-aminododecan-3-ol. | Reddy T Vijai Kumar, Prabhavathi Devi B L A, Prasad R B N, Poornima M, Ganesh Kumar C | eng | null | Journal Article, Research Support, Non-U.S. Gov't | 2-aminododecan-3-ol, Antifungal Agents, Dodecanol | IM | 22704888, S0960-894X(12)00694-4, 10.1016/j.bmcl.2012.05.082 | We report the total synthesis of (2S,3R)-2-aminododecan-3-ol has been achieved starting from commercially available 10-undecenoic acid. The key steps involved are Sharpless asymmetric epoxidation, Miyashita's boron-directed C-2 regioselective azidolysis, generated the asymmetric centers and in situ detosylation and reduction of azido tosylate. The antifungal activity of the synthesized (2S,3R)-2-aminododecan-3-ol was evaluated on several Candida strains and was comparable to miconazole, a standard drug. | Antifungal Agents, Candida, Dodecanol, Molecular Structure | null |
22,704,889 | 2013-01-04 | 2012-07-03 | 1464-3405 | Bioorganic & medicinal chemistry letters | New triterpenoid saponins from cacti and anti-type I allergy activity of saponins from cactus. | Kakuta Kazutaka, Baba Masaki, Ito Satoru, Kinoshita Kaoru, Koyama Kiyotaka, Takahashi Kunio | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Anti-Allergic Agents, Saponins, Triterpenes, beta-N-Acetylhexosaminidases | IM | 22704889, S0960-894X(12)00661-0, 10.1016/j.bmcl.2012.05.058 | The research in our laboratory focuses on the isolation of saponins from cactus. In this study, we report five new triterpenoid saponins, dumortierinoside A methyl ester (1), pachanoside I1 (2), pachanoside D1 (3), gummososide A (4), and gummososide A methyl ester (5). Compounds 1-3 isolated from Isolatocereus dumortieri Backbg., and compounds 4 and 5 were isolated from Stenocereus alamosensis A. C. Gibson & K. E. Horak. Compound 2 possessed a new pachanane-type triterpene skeleton, pachanol I, in its aglycon. The aglycon of 3 was pachanol D, while those of 4 and 5 were both gummosogenin, which we have previously reported, but this is the first report of pachanol D and gummosogenin in their aglycon forms. Additionally, we evaluated the anti-type I allergy activity of the saponins with RBL-2H3 (Rat basophilic leukemia) cells by measuring the β-hexosaminidase release inhibitory activity. As a result of these studies, gummososide A methyl ester (5) was found to show activity (IC(50)=99.5 μM) and thurberoside A exhibited mild activity (IC(50)=166.9 μM). | Animals, Anti-Allergic Agents, Cactaceae, Cell Line, Tumor, Models, Molecular, Molecular Structure, Rats, Saponins, Structure-Activity Relationship, Triterpenes, beta-N-Acetylhexosaminidases | null |
22,704,890 | 2013-01-04 | 2017-11-16 | 1464-3405 | Bioorganic & medicinal chemistry letters | Anti-herpes simplex virus efficacies of 2-aminobenzamide derivatives as novel HSP90 inhibitors. | Xiang Yang-Fei, Qian Chui-Wen, Xing Guo-Wen, Hao Jing, Xia Min, Wang Yi-Fei | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antiviral Agents, HSP90 Heat-Shock Proteins, ortho-Aminobenzoates, anthranilamide | IM | 22704890, S0960-894X(12)00691-9, 10.1016/j.bmcl.2012.05.079 | After the widespread use of the acyclic purine nucleoside analogues for therapy of herpes simplex virus (HSV) infection since the 1980s, new antiviral strategies are urgently needed to counter the emergence of drug-resistant clinical isolates. In this report, we define the anti-HSV efficacies of three optimized 2-aminobenzamide derivatives in vitro and in vivo. The synthetic analogues SNX-25a, SNX-2112 and SNX-7081, which selectively bind to the N-terminal ATP pocket of heat shock protein 90 (HSP90), exhibited significant anti-HSV-1 and HSV-2 activities at non-cytotoxic concentrations in Vero cells, with EC(50) values close to that of acyclovir (ACV). The in vivo antiviral potentials were then confirmed using a herpes simplex keratitis (HSK) rabbit model, where eye gels containing 0.1% or 0.025% SNX-25a displayed the highest efficacies against HSV-1 infection, which were better than that obtained with 0.1% ACV. SNX-2112 and SNX-7081 gels were also effective against HSV-1 with different magnitude of activities. Our results for the first time confirmed the anti-HSV efficacies of these 2-aminobenzamide derivatives and suggest that with alternative mechanisms of action these novel HSP90 inhibitors, especially SNX-25a, could be potent as new anti-HSV clinical trial candidates. | Animals, Antiviral Agents, Cell Line, Cell Survival, HSP90 Heat-Shock Proteins, Herpesvirus 1, Human, Molecular Structure, Rabbits, Structure-Activity Relationship, ortho-Aminobenzoates | null |
22,704,891 | 2013-01-04 | 2012-07-03 | 1464-3405 | Bioorganic & medicinal chemistry letters | Photoinduced DNA cleavage by anthracene based hydroxamic acids. | Chowdhury Nilanjana, Dasgupta Swagata, Pradeep Singh N D | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Anthracenes, Hydroxamic Acids, anthracene | IM | 22704891, S0960-894X(12)00696-8, 10.1016/j.bmcl.2012.05.084 | Two different series of naphthalene and anthracene based hydroxamic acids having amino acid derivatives were synthesized. Single strand DNA cleavage was achieved on irradiation of newly synthesized hydroxamic acids by UV light (≥350nm). Both reactive oxygen species (ROS) and generated radicals from hydroxamic acids were shown to be responsible for the DNA cleavage. Further, DNA cleaving ability of hydroxamic acids was found to be dependent on its concentration and on its structure. | Anthracenes, DNA Cleavage, Hydroxamic Acids, Molecular Structure, Plasmids, Structure-Activity Relationship | null |
22,704,892 | 2013-01-04 | 2015-11-19 | 1464-3405 | Bioorganic & medicinal chemistry letters | Synthesis and evaluation of novel F-18 labeled 4-aminoquinazoline derivatives: potential PET imaging agents for tumor detection. | Chen Yurong, Feng Man, Li Shilei, Xu Jingli, Ning Hongyu, He Yong, Wang Xiao, Ding Rui, Qi Chuanmin | eng | null | Journal Article, Research Support, Non-U.S. Gov't | 4-aminoquinazoline, Fluorine Radioisotopes, Quinazolines | IM | 22704892, S0960-894X(12)00672-5, 10.1016/j.bmcl.2012.05.069 | Three novel (18)F-labeled 4-aminoquinazoline derivatives, N-(3-chloro-4-fluorophenyl)-6-(2-[(18)F]fluoroethoxy)-7-methoxyquinazolin-4-amine([(18)F]1), N-(3-ethynylphenyl)-6-(2-[(18)F]fluoroethoxy)-7-methoxyquinazolin-4-amine([(18)F]2), and N-(3-bromophenyl)-6-(2-[(18)F]fluoroethoxy)-7-methoxyquinazolin-4-amine([(18)F]3) were synthesized and radiolabeled by two-step reaction with overall radiochemical yield of 21-24% (without decay corrected). Then we carried out their biodistribution experiments in S180 tumor-bearing mice. Results showed that they had certain concentration accumulation in tumor and fast clearance from muscle and blood. It was encouraging that [(18)F]3 was competitive among three (18)F-labeled 4-aminoquinazoline derivatives in some aspects such as tumor/muscle uptake ratio reaching 7.70 at 60 min post-injection, tumor/blood uptake ratio reaching 6.61 at 120 min post-injection. So we compared radioactivity characteristics of [(18)F]3 with those of [(18)F]-FDG and L-[(18)F]-FET in the same animal model. The absolute radioactivity uptake of [(18)F]3 in tumor reached 3.31 at 60 min p.i., which was slightly higher than [(18)F]-FDG (2.16) and L-[(18)F]-FET (2.75) at the same time phase. For [(18)F]3, tumor/muscle uptake ratio peaked 7.70 at 60 min, which was obviously superior to those of [(18)F]-FDG and L-[(18)F]-FET at all time points. The tumor/brain uptake ratios of [(18)F]3 were 10.36, 17.42, 41.11 at 30 min, 60 min and 120 min post-injection, respectively, and are much higher than those of L-[(18)F] FET (2.54, 2.92 and 2.95) and [(18)F]-FDG (0.61, 1.02 and 1.33) at the same time points. All these results indicate that [(18)F]3 is promising to become a potential PET tumor imaging agent. | Animals, Female, Fluorine Radioisotopes, Mice, Molecular Structure, Neoplasm Transplantation, Neoplasms, Organ Specificity, Positron-Emission Tomography, Quinazolines | null |
22,704,893 | 2012-12-21 | 2019-12-10 | 1879-0852 | European journal of cancer (Oxford, England : 1990) | Response to chemotherapy is predictive in relation to longer overall survival in an individual patient combined-analysis with pleural mesothelioma. | Blayney Jaine K, Ceresoli Giovanni L, Castagneto Bruno, O'Brien Mary E R, Hasan Baktiar, Sylvester Richard, Rudd Robin, Steele Jeremy, Busacca Sara, Porta Camillo, Mutti Luciano, O'Byrne Kenneth J, Scullin Paula, Gaafar Rabab, Baas Paul, Van Meerbeeck Jan, Fennell Dean A | eng | 5U10 CA011488-38 (NCI NIH HHS, United States); 5U10 CA011488-39 (NCI NIH HHS, United States); 5U10 CA011488-40 (NCI NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Validation Study | null | IM | 22704893, S0959-8049(12)00432-7, 10.1016/j.ejca.2012.05.018 | There is currently no early predictive marker of survival for patients receiving chemotherapy for malignant pleural mesothelioma (MPM). Tumour response may be predictive for overall survival (OS), though this has not been explored. We have thus undertaken a combined-analysis of OS, from a 42day landmark, of 526 patients receiving systemic therapy for MPM. We also validate published progression-free survival rates (PFSRs) and a progression-free survival (PFS) prognostic-index model. | Aged, Antineoplastic Combined Chemotherapy Protocols, Clinical Trials as Topic, Disease-Free Survival, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pleural Neoplasms, Proportional Hazards Models, Reproducibility of Results, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome | null |
22,704,894 | 2013-03-17 | 2022-03-10 | 1878-3562 | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver | Comparison of staging diagnosis by two magnifying endoscopy classification for superficial oesophageal cancer. | Ebi Masahide, Shimura Takaya, Murakami Kenji, Yamada Tomonori, Hirata Yoshikazu, Tsukamoto Hironobu, Mizoshita Tsutomu, Tanida Satoshi, Kataoka Hiromi, Kamiya Takeshi, Joh Takashi | eng | null | Comparative Study, Journal Article | null | IM | 22704894, S1590-8658(12)00190-9, 10.1016/j.dld.2012.05.007 | Due to the possibility of lymph node metastasis, surgical resection is indicated for superficial oesophageal cancer with invasion to a depth greater than the muscularis mucosa. Although two magnifying endoscopy classifications are currently used to diagnose the depth of invasion, which classification is more suitable remains controversial. | Aged, Carcinoma, Squamous Cell, Classification, Cross-Sectional Studies, Esophageal Neoplasms, Esophagoscopy, Female, Humans, Image Enhancement, Male, Middle Aged, Neoplasm Staging, Sensitivity and Specificity | null |
22,704,896 | 2014-09-16 | 2012-10-08 | 1873-2550 | Veterinary parasitology | The attraction range of the Onderstepoort 220V light trap for Culicoides biting midges as determined under South African field conditions. | Venter G J, Majatladi D M, Labuschagne K, Boikanyo S N B, Morey L | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22704896, S0304-4017(12)00271-3, 10.1016/j.vetpar.2012.05.019 | Despite some limitations suction light traps are the primary tools used for the collection of Culicoides species (Diptera: Ceratopogonidae). The range of attraction of the Onderstepoort light trap is not known but an insight into the range of a trap will determine where the trap must be positioned relative to the hosts present, possible breeding sites and environmental structures in the trapping vicinity. It will therefore contribute to a more meaningful interpretation and comparison of results between trapping events. In the present study the number of Culicoides midges collected in a single trap was compared to those of traps made with an additional trap respectively 1m, 4m and 8.5m away from the first. Treatments between sites were rotated in three replicates of a 4×4 Latin square design. While interactions were found in traps 4m apart no statistically significant interactions were found when they were 8.5m apart. The range of attraction, indicated by the interaction between two traps, will be between 2m and 4m. In interpreting light trap results the limitations of this collection method needs to be taken into consideration. | Animals, Ceratopogonidae, Entomology, Female, Insect Control, Insect Vectors, Light, Male, Population Surveillance, Seasons, South Africa | null |
22,704,897 | 2013-04-23 | 2018-12-01 | 1090-2414 | Ecotoxicology and environmental safety | PURE: a web-based decision support system to evaluate pesticide environmental risk for sustainable pest management practices in California. | Zhan Yu, Zhang Minghua | eng | null | Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S. | Pesticides, Chlorpyrifos | IM | 22704897, S0147-6513(12)00169-8, 10.1016/j.ecoenv.2012.05.019 | Farmers, policy makers, and other stakeholders seek tools to quantitatively assess pesticide risks for mitigating pesticide impacts on ecosystem and human health. This paper presents the Pesticide Use Risk Evaluation (PURE) decision support system (DSS) for evaluating site-specific pesticide risks to surface water, groundwater, soil, and air across pesticide active ingredient (AI), pesticide product, and field levels. The risk score is determined by the ratio of the predicted environmental concentrations (PEC) to the toxicity value for selected endpoint organism(s); except that the risk score for the air is calculated using the emission potential (EP), which is a pesticide product property for estimating potential volatile organic compound (VOC) emissions by California Environmental Protection Agency (CEPA). The risk scores range from 0 to 100, where 0 represents negligible risk while 100 means the highest risk. The procedure for calculating PEC in surface water was evaluated against monitoring data for 41 pesticide AIs, with a statistically significant correlation coefficient of r=0.82 (p<0.001). In addition, two almond fields in the Central Valley, California were evaluated for pesticide risks as a case study, where the commonly acknowledged high-risk pesticides gained high risk scores. Simazine, one of the most frequently detected pesticides in groundwater, was scored as 74 (the moderate high risk class) to groundwater; and chlorpyrifos, one of the frequently detected pollutants in surface water, was scored as 100 (the high risk class) to surface water. In support of pesticide risk quantitative assessment and use of reduced-risk pesticide selection, the PURE-DSS can be useful to assist growers, pesticide control advisors, and environmental protection organizations in mitigating pesticide use impacts on the environment. | Animals, California, Chlorpyrifos, Conservation of Natural Resources, Decision Support Techniques, Ecosystem, Humans, Internet, Pest Control, Pesticides, Prunus, Risk Assessment | null |
22,704,895 | 2012-09-13 | 2017-01-12 | 0392-856X | Clinical and experimental rheumatology | Comparison of the 1987 ACR criteria and the 2010 ACR/EULAR criteria in an inception cohort of patients with recent-onset inflammatory polyarthritis. | Reneses S, Pestana L, Garcia A | eng | null | Comparative Study, Journal Article | null | IM | 22704895, 5289 | To compare the performance of the 1987 American College of Rheumatology (ACR) and the 2010 ACR/European League Against Rheumatism criteria for the classification of rheumatoid arthritis (RA). | Adult, Age of Onset, Aged, Arthritis, Arthritis, Rheumatoid, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Sensitivity and Specificity, Severity of Illness Index | null |
22,704,898 | 2012-09-27 | 2016-05-23 | 2212-2672 | Journal of the Academy of Nutrition and Dietetics | Energy, saturated fat, and sodium were lower in entrées at chain restaurants at 18 months compared with 6 months following the implementation of mandatory menu labeling regulation in King County, Washington. | Bruemmer Barbara, Krieger Jim, Saelens Brian E, Chan Nadine | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't | Dietary Fats, Sodium, Dietary | IM | 22704898, S2212-2672(12)00592-8, 10.1016/j.jand.2012.04.019 | Policies on menu labeling have been proposed as a method to improve the food environment. However, there is little information on the nutrient content of chain restaurant menu items and changes over time. | Dietary Fats, Energy Intake, Food Analysis, Food Labeling, Guideline Adherence, Humans, Menu Planning, Nutrition Policy, Nutritive Value, Restaurants, Sodium, Dietary, Time Factors, Washington | null |
22,704,899 | 2012-09-27 | 2024-06-10 | 2212-2672 | Journal of the Academy of Nutrition and Dietetics | The Automated Self-Administered 24-hour dietary recall (ASA24): a resource for researchers, clinicians, and educators from the National Cancer Institute. | Subar Amy F, Kirkpatrick Sharon I, Mittl Beth, Zimmerman Thea Palmer, Thompson Frances E, Bingley Christopher, Willis Gordon, Islam Noemi G, Baranowski Tom, McNutt Suzanne, Potischman Nancy | eng | Y99 CA999999 (NCI NIH HHS, United States); Z99 CA999999 (Intramural NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural | null | IM | 22704899, S2212-2672(12)00589-8, 10.1016/j.jand.2012.04.016, PMC3721511, NIHMS372533, 17524721, 12835281, 20102832, 21073772, 20102828, 14681273, 20161418, 18689367 | null | Automation, Cost-Benefit Analysis, Diet, Diet Surveys, Dietetics, Humans, Internet, Interviews as Topic, Mental Recall, National Cancer Institute (U.S.), Nutrition Assessment, Reproducibility of Results, Research, Self Report, Sensitivity and Specificity, Surveys and Questionnaires, United States | null |
22,704,901 | 2013-08-07 | 2012-12-25 | 1873-5126 | Parkinsonism & related disorders | 'Jaw clenching' in anti-Ri--antibody-associated paraneoplastic syndrome. | Bekircan-Kurt Can Ebru, Temucin Çagri Mesut, Elibol Bulent, Saka Esen | eng | null | Case Reports, Letter | Antibodies, Antigens, Neoplasm | IM | 22704901, S1353-8020(12)00193-9, 10.1016/j.parkreldis.2012.05.013 | null | Antibodies, Antigens, Neoplasm, Brain, Brain Neoplasms, Electromyography, Female, Humans, Middle Aged, Paraneoplastic Syndromes | null |
22,704,903 | 2012-11-29 | 2012-07-09 | 1096-0457 | Journal of experimental child psychology | Substitution and sameness: two components of a relational conception of the equals sign. | Jones Ian, Inglis Matthew, Gilmore Camilla, Dowens Margaret | eng | null | Comparative Study, Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22704903, S0022-0965(12)00086-0, 10.1016/j.jecp.2012.05.003 | A sophisticated and flexible understanding of the equals sign (=) is important for arithmetic competence and for learning further mathematics, particularly algebra. Research has identified two common conceptions held by children: the equals sign as an operator and the equals sign as signaling the same value on both sides of the equation. We argue here that, in addition to these two conceptions, the notion of substitution is also an important part of a sophisticated understanding of mathematical equivalence. We provide evidence from a cross-cultural study in which English and Chinese children were asked to rate the "cleverness" of operational, sameness, and substitutive definitions of the equals sign. A principal components analysis revealed that the substitutive items were distinct from the sameness items. Furthermore, Chinese children rated the substitutive items as 'sort of clever' or 'very clever', whereas English children rated them as not so clever, suggesting that the notion of substitution develops differently across the two countries. Implications for developmental models of children's understanding of equivalence are discussed. | Association Learning, Child, China, Concept Formation, Cross-Cultural Comparison, England, Female, Humans, Male, Mathematics, Principal Component Analysis, Problem Solving, Semantics | null |
22,704,902 | 2013-05-03 | 2019-12-10 | 1873-5126 | Parkinsonism & related disorders | Patient-centeredness in PD care: development and validation of a patient experience questionnaire. | van der Eijk Martijn, Faber Marjan J, Ummels Inez, Aarts Johanna W M, Munneke Marten, Bloem Bastiaan R | eng | null | Journal Article | null | IM | 22704902, S1353-8020(12)00205-2, 10.1016/j.parkreldis.2012.05.017 | Patient-centeredness is increasingly recognized as a crucial element of quality of care. A suitable instrument to assess the level of patient-centeredness for Parkinson's disease (PD) care is lacking. Here we describe the development and validation of the Patient-Centered Questionnaire for PD (PCQ-PD), and its initial application in a large patient sample. | Aged, Aged, 80 and over, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Netherlands, Outcome Assessment, Health Care, Parkinson Disease, Patient Satisfaction, Patient-Centered Care, Psychometrics, Reproducibility of Results, Surveys and Questionnaires | null |
22,704,904 | 2013-04-11 | 2012-10-08 | 1873-1716 | Preventive veterinary medicine | Risk factors associated with brucellosis seropositivity among cattle in the central savannah-forest area of Ivory Coast. | Sanogo Moussa, Abatih Emmanuel, Thys Eric, Fretin David, Berkvens Dirk, Saegerman Claude | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antibodies, Bacterial | IM | 22704904, S0167-5877(12)00166-3, 10.1016/j.prevetmed.2012.05.010 | Serological results obtained from 907 serum samples collected from unvaccinated cattle of at least 6 months of age in the savannah-forest region of Ivory Coast were used to investigate risk factors associated with bovine brucellosis seropositivity. Serum samples were tested using the Rose Bengal test (RBT) and indirect enzyme linked immunosorbent assay (iELISA). Using a parallel interpretation, RBT and iELISA results showed that 10.3% (95% confidence interval (CI): 8.4, 12.4) of the cattle had antibodies against Brucella in our study area. The logistic regression analysis indicated that brucellosis seropositivity was associated with age and herd size. Cattle above 5 years of age were found to have a higher chance of being seropositive (odd ratio (OR)=2.8; 95% CI: 1.3, 6.4) compared to cattle under 3 years of age. Similarly, the odd of brucellosis seropositivity for herds with more than 100 cattle was 3.3 (95% CI: 1.2, 8.9) times higher compared to those with less than 50 cattle. | Animals, Antibodies, Bacterial, Brucella, Brucellosis, Bovine, Cattle, Cote d'Ivoire, Enzyme-Linked Immunosorbent Assay, Female, Logistic Models, Male, Seroepidemiologic Studies | null |
22,704,905 | 2012-12-04 | 2016-11-25 | 0965-206X | Journal of tissue viability | Achieving consensus in pressure ulcer reporting. | Dealey Carol, Chambers Tina, Beldon Pauline, Benbow Maureen, Fletcher Jacqui, Fumarola Sian, Guy Heidi, Nixon Jane, Price Juliet, Purser Kate, Stubbs Nikki, Way Louisa, Weafer Karen | eng | null | Consensus Development Conference, Journal Article | null | null | 22704905, S0965-206X(12)00020-4, 10.1016/j.jtv.2012.05.001 | Pressure ulcers are considered to be a key quality indicator and healthcare providers in England are required to report local pressure ulcer rates. However, there is a lack of standardisation in reporting due to lack of national guidance. The Tissue Viability Society has sought to develop consensus amongst all concerned parties on the most useful and robust methods of data collection. This document has been developed following a consensus meeting and consultation with the majority of Tissue Viability Nurses across England and provides guidance on reporting pressure ulcer rates. It is intended for use all organisations that are involved in the reporting of pressure ulcers. It represents the consensus view of a large number of Tissue Viability Nurses from across England and we recommend its adoption. | Data Collection, Humans, Incidence, Mandatory Reporting, Practice Guidelines as Topic, Pressure Ulcer, Societies, Nursing, United Kingdom | null |
22,704,907 | 2013-12-05 | 2015-11-19 | 1695-9531 | Anales de pediatria (Barcelona, Spain : 2003) | [Prognostic markers of mortality after congenital heart defect surgery]. | García-Hernández J A, Benítez-Gómez I L, Martínez-López A I, Praena-Fernández J M, Cano-Franco J, Loscertales-Abril M | spa | null | English Abstract, Journal Article | Biomarkers | IM | 22704907, S1695-4033(12)00180-4, 10.1016/j.anpedi.2012.03.021 | Our aim is to identify risk factors for mortality after surgery for congenital heart disease in children, in order to establish indications for extracorporeal membrane oxygenation (ECMO). | Biomarkers, Child, Preschool, Extracorporeal Membrane Oxygenation, Heart Defects, Congenital, Hospital Mortality, Humans, Infant, Infant, Newborn, Postoperative Complications, Prognosis, Prospective Studies, Risk Factors | null |
22,704,906 | 2012-11-05 | 2013-11-21 | 1873-2976 | Bioresource technology | Methane yield through anaerobic digestion for various maize varieties in China. | Gao Ruifang, Yuan Xufeng, Zhu Wanbin, Wang Xiaofen, Chen Shaojiang, Cheng Xu, Cui Zongjun | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Methane | IM | 22704906, S0960-8524(12)00795-X, 10.1016/j.biortech.2012.05.051 | The methane potential of nine varieties of fresh maize harvested at three different times and of maize silage was experimentally determined in batch assays. The ultimate methane productivity in terms of volatile solids (VS) was determined as 213.94-313.63, 195.88-334.81 mL/g VS from several fresh and silage maize in three stages, respectively. The average specific methane yield of wax ripeness stage for fresh maize and full ripeness stage for silage maize were higher than that of other stages, respectively. The high-oil varieties of fresh maize and silage varieties of ensiling maize could produce more methane than general varieties in the same ripeness stage. Methane yield of ensiled materials was higher than fresh material. The methane yields of fresh and silage maize in full ripeness stage were ranged 5656-7956 and 4633-8915 m(3)/ha, respectively. The corresponding maximum of methane yield came from fresh HO5580 and silage CAU No. 4. | Anaerobiosis, Biomass, Biotechnology, China, Methane, Silage, Zea mays | null |
22,704,909 | 2013-12-05 | 2012-11-26 | 1695-9531 | Anales de pediatria (Barcelona, Spain : 2003) | [An unusual cause of intestinal obstruction in children: intestinal haematoma due to low molecular weight heparin]. | López López R, Marañón Pardillo R, Vázquez López P | spa | null | Case Reports, Letter | Anticoagulants, Heparin, Low-Molecular-Weight | IM | 22704909, S1695-4033(12)00253-6, 10.1016/j.anpedi.2012.04.015 | null | Anticoagulants, Hematoma, Heparin, Low-Molecular-Weight, Humans, Infant, Intestinal Diseases, Intestinal Obstruction, Intestines, Male | null |
22,704,908 | 2014-01-06 | 2013-01-15 | 1695-9531 | Anales de pediatria (Barcelona, Spain : 2003) | [Perinatal aspects, growth and feeding of infants born small for gestational age]. | Biosca Pàmies M, Rodríguez Martínez G, Samper Villagrasa M P, Odriozola Grijalba M, Cuadrón Andrés L, Álvarez Sauras M L, Moreno Aznar L A, Olivares López J L | spa | null | English Abstract, Journal Article, Research Support, Non-U.S. Gov't | null | IM | 22704908, S1695-4033(12)00255-X, 10.1016/j.anpedi.2012.05.002 | Being born small for gestational age (SGA) has short and long term risks. The aim of this study was to describe perinatal and socio-cultural characteristics, and the pattern of growth and diet of SGA infants during their first 6 months of life. | Diet, Female, Humans, Infant, Infant, Newborn, Infant, Small for Gestational Age, Male | null |
22,704,911 | 2012-11-06 | 2012-07-17 | 1471-5007 | Trends in parasitology | Thinking Blastocystis out of the box. | Stensvold Christen Rune | eng | null | Letter | null | IM | 22704911, S1471-4922(12)00087-6, 10.1016/j.pt.2012.05.004 | null | Blastocystis, Blastocystis Infections, Genomics, Humans, Research | null |
22,704,910 | 2012-11-06 | 2013-11-21 | 1471-5007 | Trends in parasitology | An alternative form of melarsoprol in sleeping sickness. | Kennedy Peter G E | eng | null | Journal Article | Trypanocidal Agents, Melarsoprol | IM | 22704910, S1471-4922(12)00086-4, 10.1016/j.pt.2012.05.003 | Human African trypanosomiasis (HAT), or sleeping sickness, is a major threat to human health throughout sub-Saharan Africa. Almost always fatal if untreated or inadequately treated, a commonly used drug for treating late-stage HAT, and the only drug for late-stage Trypanosoma brucei rhodesiense, is intravenous melarsoprol, which kills 5% of patients receiving it. Melarsoprol cyclodextrin inclusion complexes have been tested in a highly reliable mouse model of HAT. These complexes increase the oral bioavailability of melarsoprol making them effective orally and both curative and nontoxic in doses that are equivalent to those of intravenous melarsoprol. It is argued that a small clinical trial of this drug in HAT is justified to potentially improve the outcome of patients with late-stage rhodesiense disease. | Administration, Oral, Animals, Clinical Trials as Topic, Humans, Infusion Pumps, Melarsoprol, Mice, Trypanocidal Agents, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense, Trypanosomiasis, African | null |
22,704,912 | 2012-11-30 | 2016-11-25 | 1615-5947 | Annals of vascular surgery | Novel repair of an external iliac vein aneurysm. | Jayaraj Arjun, Meissner Mark | eng | null | Case Reports, Journal Article | null | IM | 22704912, S0890-5096(12)00169-0, 10.1016/j.avsg.2011.12.007 | Aneurysms involving the venous system are a rare entity. We report the case of a 37-year-old woman who presented to us with activity-limiting left gluteal pain and who on consequent workup was found to have a left external iliac vein aneurysm in a setting of iliocavomegaly. She underwent successful treatment of her aneurysm with a novel approach that involved staple plication and resection of the aneurysm over a balloon mandrel. We discuss the presentation, diagnosis, and surgical technique adopted for the treatment of this uncommon condition. | Adult, Aneurysm, Angioplasty, Balloon, Buttocks, Female, Humans, Iliac Vein, Pain, Phlebography, Stents, Surgical Stapling, Tomography, X-Ray Computed, Treatment Outcome, Vascular Surgical Procedures | null |
22,704,913 | 2013-01-10 | 2021-10-21 | 1873-2054 | Health & place | The built environment & the impact of neighborhood characteristics on youth sexual risk behavior in Cape Town, South Africa. | Burns Paul A, Snow Rachel C | eng | R24 HD041028 (NICHD NIH HHS, United States); T32 AG000221 (NIA NIH HHS, United States); 5T32AG00021-19 (NIA NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't | null | null | 22704913, S1353-8292(12)00075-5, 10.1016/j.healthplace.2012.04.013, PMC3483073, NIHMS387690, 15088679, 20140533, 10342798, 17958708, 7761908, 20846768, 15162080, 10681886, 12604497, 18375613, 17954681, 11759779, 12948949, 12948961, 21228293, 11988443, 12146745, 15886139, 12650386, 11684601, 15016244, 10667184, 12753816, 15688569, 12948983, 15629682, 14709705, 17985816, 10868674, 20201871, 12343496, 15020014, 17329713, 9252316, 12948962, 16380565, 11682328, 17694431, 21729360, 16798055, 9158474, 19711807, 10981471, 8211307, 10681893, 17201542, 10784551, 17440667, 12365533, 18771063, 15487845, 15038149, 12137182, 21161414 | Youth sexual risk behavior is often described in social terms, and there has been limited attention to date on how measures of the built environment, including access to municipal services, impact sexual risk behavior, particularly in resource-limited countries. Using the Cape Area Panel Study, we assessed the impact of neighborhood conditions (six single items and a built environment index (BEI)), net of individual socio-demographic factors. The results suggest that built environment factors are associated with sexual risk behavior. Also, the magnitude of associations between built environment factors and sexual risk behavior was more pronounced for females than for males. | Cross-Sectional Studies, Environment Design, Female, Humans, Male, Residence Characteristics, Sexual Behavior, South Africa, Unsafe Sex | null |
22,704,915 | 2012-10-26 | 2015-11-19 | 1873-6327 | Addictive behaviors | A population-based cohort study of anxiety, depression, sleep and alcohol outcomes among benzodiazepine and z-hypnotic users. | Nordfjærn Trond | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Hypnotics and Sedatives, Benzodiazepines | IM | 22704915, S0306-4603(12)00219-5, 10.1016/j.addbeh.2012.05.017 | The present study aimed to examine anxiety, depression, sleep and alcohol outcomes among individuals who were prescribed benzodiazepines or z-hypnotics in a Norwegian population-based sample (n = 58,967). | Adolescent, Adult, Aged, Alcohol Drinking, Anxiety Disorders, Benzodiazepines, Depressive Disorder, Female, Follow-Up Studies, Humans, Hypnotics and Sedatives, Male, Middle Aged, Norway, Prospective Studies, Self Report, Sleep Wake Disorders, Treatment Outcome, Young Adult | null |
22,704,916 | 2013-08-05 | 2016-10-20 | 1876-4479 | Journal of Crohn's & colitis | Subgroup analysis of the placebo-controlled CHARM trial: increased remission rates through 3 years for adalimumab-treated patients with early Crohn's disease. | Schreiber S, Reinisch W, Colombel J F, Sandborn W J, Hommes D W, Robinson A M, Huang B, Lomax K G, Pollack P F | eng | null | Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | Anti-Inflammatory Agents, Antibodies, Monoclonal, Humanized, Adalimumab | IM | 22704916, S1873-9946(12)00257-7, 10.1016/j.crohns.2012.05.015 | We examined the impact of disease duration on clinical outcomes and safety in a post hoc analysis of a remission maintenance trial with adalimumab in patients with moderate to severe CD. | Adalimumab, Adolescent, Adult, Aged, Anti-Inflammatory Agents, Antibodies, Monoclonal, Humanized, Crohn Disease, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Induction Chemotherapy, Kaplan-Meier Estimate, Logistic Models, Maintenance Chemotherapy, Male, Middle Aged, Severity of Illness Index, Time Factors, Treatment Outcome, Young Adult | null |
22,704,918 | 2012-11-09 | 2012-07-13 | 1872-7972 | Neuroscience letters | Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson's disease. | Belin Andrea Carmine, Ran Caroline, Anvret Anna, Paddock Silvia, Westerlund Marie, Håkansson Anna, Nissbrandt Hans, Söderkvist Peter, Dizdar Nil, Ahmadi Ahmad, Anvret Maria, Willows Thomas, Sydow Olof, Galter Dagmar | eng | null | Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't | Aryldialkylphosphatase, PON1 protein, human | IM | 22704918, S0304-3940(12)00791-4, 10.1016/j.neulet.2012.06.007 | Pesticide exposure has been suggested to increase the risk to develop Parkinson's disease (PD). The arylesterase paraoxonase 1 (PON1) is mainly expressed in the liver and hydrolyzes organophosphates such as pesticides. The polymorphism Leu54Met (rs854560) in PON1, impairing enzyme activity and leading to decreased PON1 expression levels, has been reported to be associated with Parkinson's disease (PD). PON1 is part of a cluster on chromosome 7q21.3 together with PON2 and PON3. We investigated the occurrence of four additional polymorphisms in PON1 and two in PON2 in a Swedish PD case-control material. We found a significant association (p=0.007) with a PON1 promoter polymorphism, rs854571. The minor allele was more common among controls than PD cases which suggest a protective effect. This is strengthened by the fact that rs854571 is in strong linkage disequilibrium with another PON1 promoter polymorphism, rs854572, reported to increase PON1 gene expression. Our findings support the hypothesis that PON1 is involved in the etiology of PD and that higher PON1 levels are reducing the risk for PD. | Adult, Aged, Aged, 80 and over, Aryldialkylphosphatase, Case-Control Studies, Female, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parkinson Disease, Polymorphism, Genetic | null |
22,704,917 | 2012-11-30 | 2015-11-19 | 1872-6216 | Mechanisms of ageing and development | Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. | Lee Janice S, Ward William O, Ren Hongzu, Vallanat Beena, Darlington Gretchen J, Han Eun-Soo, Laguna Juan C, DeFord James H, Papaconstantinou John, Selman Colin, Corton J Christopher | eng | null | Journal Article, Research Support, U.S. Gov't, Non-P.H.S. | Biomarkers | IM | 22704917, S0047-6374(12)00100-5, 10.1016/j.mad.2012.05.006 | Aging is associated with a loss of cellular homeostasis, a decline in physiological function and an increase in various pathologies. Employing a meta-analysis, hepatic gene expression profiles from four independent mouse aging studies were interrogated. There was little overlap in the number of genes or canonical pathways perturbed, suggesting that independent study-specific factors may play a significant role in determining age-dependent gene expression. However, 43 genes were consistently altered during aging in three or four of these studies, including those that (1) exhibited progressively increased expression starting from 12 months of age, (2) exhibited similar expression changes in models of progeria at young ages and dampened or no changes in old longevity mouse models, (3) were associated with inflammatory tertiary lymphoid neogenesis (TLN) associated with formation of ectopic lymphoid structures observed in chronically inflamed tissues, and (4) overlapped with genes perturbed by aging in brain, muscle, and lung. Surprisingly, around half of the genes altered by aging in wild-type mice exhibited similar expression changes in adult long-lived mice compared to wild-type controls, including those associated with intermediary metabolism and feminization of the male-dependent gene expression pattern. Genes unique to aging in wild-type mice included those linked to TLN. | Aging, Animals, Biomarkers, Gene Expression Regulation, Inflammation, Liver, Male, Mice, Transcriptome | null |
22,704,914 | 2012-11-29 | 2015-11-19 | 1885-1398 | Reumatologia clinica | Catastrophic health expenses and impoverishment of households of patients with rheumatoid arthritis. | Álvarez-Hernández Everardo, Peláez-Ballestas Ingris, Boonen Annelies, Vázquez-Mellado Janitzia, Hernández-Garduño Adolfo, Rivera Fernando Carlos, Teran-Estrada Leobardo, Ventura-Ríos Lucio, Ramos-Remus César, Skinner-Taylor Cassandra, Goycochea-Robles Maria Victoria, Bernard-Medina Ana Guislaine, Burgos-Vargas Rubén | eng | null | Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't | Anti-Inflammatory Agents, Antirheumatic Agents | IM | 22704914, S1699-258X(12)00135-0, 10.1016/j.reuma.2012.05.002 | The cost of certain diseases may lead to catastrophic expenses and impoverishment of households without full financial support by the state and other organizations. | Adult, Anti-Inflammatory Agents, Antirheumatic Agents, Arthritis, Rheumatoid, Catastrophic Illness, Cohort Studies, Cost of Illness, Cross-Sectional Studies, Family, Female, Food Supply, Health Expenditures, Humans, Income, Insurance, Health, Male, Medically Uninsured, Mexico, Middle Aged, National Health Programs, Poverty, Private Sector, Quality of Life, Social Security, Surveys and Questionnaires, Young Adult | null |
22,704,919 | 2013-01-17 | 2019-12-10 | 1095-8320 | Biologicals : journal of the International Association of Biological Standardization | A study on the use of caprylic acid and ammonium sulfate in combination for the fractionation of equine antivenom F(ab')(2). | Simsiriwong Pavinee, Eursakun Sukanya, Ratanabanangkoon Kavi | eng | null | Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't | Antivenins, Caprylates, Drug Combinations, Immunoglobulin Fab Fragments, Snake Venoms, Pepsin A, octanoic acid, Ammonium Sulfate | IM | 22704919, S1045-1056(12)00074-7, 10.1016/j.biologicals.2012.05.002 | This study involved the fractionation of equine antivenom F(ab')(2) by combined stepwise ammonium sulfate (AS) and caprylic acid (CA) precipitation without intermediate separation of precipitate. Using a microplate format, 55 conditions with combinations of AS (0-20% saturation) and CA (0-5% v/v), were tested. AS significantly reduced the turbidity raised by CA. High specific antibody activity was observed in the area containing 2-5% CA and 10-20% AS. From these results, 12 precipitation conditions were selected for detailed quantitative studies. Two combinations, one with 4% CA and 15% AS and another with 5% CA and 20% AS, gave the highest fold-purification (1.79 and 1.83) with antibody recoveries at 68% and 59%, respectively. These combinations offered a benefit over CA alone in reducing the turbidity and in increasing the purity but not the recovery of antibody. The conditions giving more favorable overall results were with 2% CA alone and another with a combination of 1.5% CA and 10% AS. These preparations of F(ab')(2) were homogeneous and without protein aggregate under size-exclusion HPLC. Lastly, 1 h precipitation showed better results than those of overnight precipitation. These results could be useful for the production of therapeutic antivenoms. | Ammonium Sulfate, Animals, Antivenins, Caprylates, Chemical Fractionation, Chemical Precipitation, Chromatography, High Pressure Liquid, Drug Combinations, Horses, Immunoglobulin Fab Fragments, Nephelometry and Turbidimetry, Pepsin A, Proteolysis, Snake Venoms | null |
22,704,920 | 2013-03-12 | 2012-08-27 | 1532-2130 | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society | Diagnosis and long-term course of Dravet syndrome. | Scheffer Ingrid E | eng | null | Journal Article, Review | NAV1.1 Voltage-Gated Sodium Channel, SCN1A protein, human | IM | 22704920, S1090-3798(12)00097-9, 10.1016/j.ejpn.2012.04.007 | Dravet syndrome is a severe infantile-onset epilepsy syndrome with a distinctive but complex electroclinical presentation. A healthy, developmentally normal infant presents at around 6 months of age with convulsive status epilepticus, which may be hemiclonic or generalized; seizures may be triggered by fever, illness or vaccination. The infant typically has further episodes of status epilepticus every month or two, often triggered by fever. Other seizure types including focal dyscognitive seizures, absence and myoclonic seizures develop between 1 and 4 years. Atonic drop attacks and episodes of non-convulsive status may occur. Early development is normal but slows in the second year. Developmental regression may occur, particularly with status epilepticus. EEG studies are initially normal, but after 2 years they show generalized spike-wave and polyspike-wave activity with multifocal discharges. Photosensitivity may be seen. Imaging is normal or shows non-specific findings such as atrophy. Dravet syndrome is associated with mutations of the gene encoding the alpha-1 subunit of the sodium channel, SCN1A, in >70% of patients. These include sequencing mutations and copy number variant anomalies; 90% of mutations arise de novo. PCDH19 mutational analysis is a second-tier test for girls with a Dravet-like picture who do not have SCN1A mutations. Outcome is poor, with intellectual disability in most patients and ongoing seizures. Intellectual impairment varies from severe in 50% patients, to moderate and mild intellectual disability each accounting for 25% cases. Rare patients have normal intellect. The long-term course involves ongoing, brief nocturnal convulsions and a characteristic deterioration in gait. | Epilepsies, Myoclonic, Epilepsy, Generalized, Gene Dosage, Genetic Predisposition to Disease, Humans, NAV1.1 Voltage-Gated Sodium Channel, Time Factors | null |
22,704,921 | 2013-01-04 | 2012-07-03 | 1464-3405 | Bioorganic & medicinal chemistry letters | Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template. | Mohamed Tarek, Yeung Jacky C K, Vasefi Maryam S, Beazely Michael A, Rao Praveen P N | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Amyloid beta-Peptides, Diamines, Pyrimidines | IM | 22704921, S0960-894X(12)00689-0, 10.1016/j.bmcl.2012.05.077 | We investigated a group of 2-benzylpiperidin-N-benzylpyrimidin-4-amines with various electron-withdrawing or electron-donating groups (EWGs or EDGs, respectively) as multi-targeted Alzheimer's disease (AD) therapeutics. The synthesized derivatives were screened for anti-cholinesterase (AChE and BuChE), anti-Aβ-aggregation (AChE- and self-induced) and anti-β-secretase (BACE-1) activities in an effort to identify lead, multifunctional candidates as part of our multi-targeted approach to treat AD. Biological assessment revealed that the nature of the substituent on the C-4 benzylamine group (e.g., halogen vs methoxy-based) greatly affected the biological profile. In vitro screening identified N(2)-(1-benzylpiperidin-4-yl)-N(4)-(3,4-dimethoxybenzyl)pyrimidine-2,4-diamine (7h) as the lead candidate with a dual ChE (AChE IC(50)=9.9 μM; BuChE IC(50)=11.4 μM), Aβ-aggregation (AChE-induced=59.3%; self-induced=17.4% at 100 μM) and BACE-1 (34% inhibition at 10 μM) inhibitory profile along with good cell viability (% neuroblastoma cell viability at 40 μM=81.0%). Molecular modeling studies indicate that a central pyrimidine-2,4-diamine ring serves as a suitable template to develop novel small molecule candidates to target multiple pathological routes in AD. | Alzheimer Disease, Amyloid beta-Peptides, Cell Line, Tumor, Cell Survival, Diamines, Humans, Models, Molecular, Molecular Structure, Pyrimidines, Retinoblastoma, Structure-Activity Relationship | null |
22,704,922 | 2013-01-04 | 2012-07-03 | 1464-3405 | Bioorganic & medicinal chemistry letters | Novel macrocyclic and acyclic cationic lipids for gene transfer: synthesis and in vitro evaluation. | Goldring William P D, Jubeli Emile, Downs Rachael A, Johnston Adam J S, Abdul Khalique Nada, Raju Liji, Wafadari Deena, Pungente Michael D | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Cations, Lipids, Macrocyclic Compounds | IM | 22704922, S0960-894X(12)00692-0, 10.1016/j.bmcl.2012.05.080 | The synthesis and in vitro evaluation of four cationic lipid gene delivery vectors, characterized by acyclic or macrocyclic, and saturated or unsaturated hydrophobic regions, is described. The synthesis employed standard protocols, including ring-closing metathesis for macrocyclic lipid construction. All lipoplexes studied, formulated from plasmid DNA and a liposome composed of a synthesized lipid, 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (EPC), and either 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) or cholesterol as co-lipid, exhibited plasmid DNA binding and protection from DNase I degradation, and concentration dependent cytotoxicity using Chinese hamster ovary-K1 cells. The transfection efficiency of formulations with cholesterol outperformed those with DOPE, and in many cases the EPC/cholesterol control, and formulations with a macrocyclic lipid (+/- 10:1) outperformed their acyclic counterparts (+/- 3:1). | Animals, CHO Cells, Cations, Cell Survival, Cricetinae, Lipids, Macrocyclic Compounds, Structure-Activity Relationship, Transfection | null |
22,704,923 | 2013-01-04 | 2012-07-03 | 1464-3405 | Bioorganic & medicinal chemistry letters | Semi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea. | Srikanth Reddy T, Suryakiran N, Narasimhulu M, Ramesh D, Chinni Mahesh K, Sai Krishna A, Kavitha P, Venkateswara Rao J, Venkateswarlu Y | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Halogenated Diphenyl Ethers | IM | 22704923, S0960-894X(12)00620-8, 10.1016/j.bmcl.2012.04.133 | The sponge Dysidea herbacea was collected from the Mandapam Coast, Tamilnadu, India. Isolated gram quantities of hydroxylated polybrominated diphenyl ether (HO-PBDE) and semi-synthesized a series of new PBDEs derivatives and tested them for antibacterial and cytotoxic activities. | Animals, Cell Line, Tumor, Cell Survival, Dysidea, Halogenated Diphenyl Ethers, Humans, Molecular Structure | null |
22,704,925 | 2013-01-10 | 2012-09-05 | 1873-2518 | Vaccine | Efficacy of a vaccine and a direct-fed microbial against fecal shedding of Escherichia coli O157:H7 in a randomized pen-level field trial of commercial feedlot cattle. | Cull Charley A, Paddock Zachary D, Nagaraja T G, Bello Nora M, Babcock Abram H, Renter David G | eng | null | Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S. | Bacterial Outer Membrane Proteins, Escherichia coli Vaccines, Porins, Receptors, Cell Surface, siderophore receptors | IM | 22704925, S0264-410X(12)00832-8, 10.1016/j.vaccine.2012.05.080 | Our primary objective was to determine the efficacy of a siderophore receptor and porin proteins-based vaccine (VAC) and a Lactobacillus acidophilus-based direct-fed microbial (DFM) against fecal shedding of Escherichia coli O157:H7 in commercial feedlot cattle fed a corn grain-based diet with 25% distiller's grains. Cattle projected to be on a finishing diet during the summer were randomly allocated into 40 study pens within ten blocks based on allocation dates. Blocks were complete; each of the four pens within a block was randomly assigned one treatment: control, VAC, DFM, or VAC+DFM. The DFM was fed (10⁶CFU/animal/day of Lactobacillus) throughout the study periods (84-88 days) and cattle were vaccinated at enrollment and again three weeks later. Fresh fecal samples (30/pen) from pen floors were collected weekly for four consecutive weeks (study days 52-77). Two concurrent culture procedures were used to enable estimates of E. coli O157:H7 shedding prevalence and prevalence of high shedders. From 4800 total samples, 1522 (31.7%) were positive for E. coli O157:H7 and 169 (3.5%) were considered high shedders. Pen-level linear mixed models were used for data analyses. There were no significant interactions among treatments and time of sampling. However, vaccinated pens had lower (P<0.01) overall prevalence of E. coli O157:H7 (model-adjusted mean ± SEM=17.4 ± 3.95%) and lower (P<0.01) prevalence of high shedders (0.95 ± 0.26%) than unvaccinated pens (37.0 ± 6.32% and 4.19 ± 0.81%, respectively). There was no evidence of a DFM effect on either measure of E. coli O157:H7 shedding. Results indicate that a two-dose regimen of the vaccine significantly reduces fecal prevalence of E. coli O157:H7 (vaccine efficacy of 53.0%) and prevalence of E. coli O157:H7 high shedders (vaccine efficacy of 77.3%) in commercial feedlot cattle reared in the summer on a finishing diet with 25% distiller's grains. | Animal Feed, Animals, Bacterial Outer Membrane Proteins, Bacterial Shedding, Cattle, Cattle Diseases, Escherichia coli Infections, Escherichia coli O157, Escherichia coli Vaccines, Feces, Male, Porins, Receptors, Cell Surface | null |
22,704,924 | 2012-11-08 | 2012-07-10 | 1873-2518 | Vaccine | Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis. | Agallou Maria, Smirlis Despina, Soteriadou Ketty P, Karagouni Evdokia | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Antibodies, Protozoan, Antigens, Protozoan, Histones, Immunoglobulin G, Leishmaniasis Vaccines, Oligonucleotides, Interleukin-10, Interleukin-12, Interleukin-4, Interferon-gamma | IM | 22704924, S0264-410X(12)00827-4, 10.1016/j.vaccine.2012.05.075 | Visceral leishmaniasis is the most severe form of leishmaniases affecting millions of people worldwide often resulting in death despite optimal therapy. Thus, there is an urgent need for the development of effective anti-infective vaccine(s). In the present study, we evaluated the prophylactic value of bone marrow-derived dendritic cells (BM-DCs) pulsed with the Leishmania (L.) infantum histone H1. We developed fully mature BM-DCs characterized by enhanced capacity of IL-12 production after ex vivo pulsing with GST-LeishH1. Intravenous administration of these BM-DCs in naive BALB/c mice resulted in antigen-specific spleenocyte proliferation and IgG1 isotype antibody production and conferred protection against experimental challenge with L. infantum independently of CpG oligonucleotides (ODNs) co-administration. Protection was associated with a pronounced enhancement of parasite-specific IFNγ-producing cells and reduction of cells producing IL-10, whereas IL-4 production was comparable in protected and non-protected mice. The polarization of immune responses to Th1 type was further confirmed by the elevation of parasite-specific IgG2a/IgG1 ratio in protected mice. The above data indicate the immunostimulatory capacity of Leishmania histone H1 and further support its exploitation as a candidate protein for vaccine development against leishmaniasis. | Animals, Antibodies, Protozoan, Antibody Formation, Antigens, Protozoan, Bone Marrow Cells, Cell Proliferation, Dendritic Cells, Female, Histones, Immunity, Cellular, Immunoglobulin G, Injections, Intravenous, Interferon-gamma, Interleukin-10, Interleukin-12, Interleukin-4, Leishmania infantum, Leishmaniasis Vaccines, Leishmaniasis, Visceral, Mice, Mice, Inbred BALB C, Oligonucleotides, Spleen | null |
22,704,926 | 2012-12-21 | 2012-07-20 | 1873-2518 | Vaccine | Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults. | Halperin Scott A, McNeil Shelly, Langley Joanne M, Smith Bruce, MacKinnon-Cameron Donna, McCall-Sani Robyn, Heyward William L, Martin J Tyler | eng | null | Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't | Adjuvants, Immunologic, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Oligodeoxyribonucleotides, Phosphorothioate Oligonucleotides | IM | 22704926, S0264-410X(12)00826-2, 10.1016/j.vaccine.2012.05.074 | Previous studies have shown that two doses of an investigational hepatitis B vaccine consisting of hepatitis B surface antigen combined with an immunostimulatory phosphorothioate oligodeoxyribonucleotide adjuvant (HBV-ISS) given 8 weeks apart provides seroprotection sooner than 3 doses of a licensed hepatitis B vaccine over 24 weeks. A more rapid schedule with a 4-week interval could provide earlier protection and potentially greater compliance. | Adjuvants, Immunologic, Adult, Female, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B Vaccines, Humans, Male, Oligodeoxyribonucleotides, Phosphorothioate Oligonucleotides, Young Adult | null |
22,704,927 | 2012-10-30 | 2021-10-21 | 1879-2448 | Water research | Transport behavior of functionalized multi-wall carbon nanotubes in water-saturated quartz sand as a function of tube length. | Wang Yonggang, Kim Jae-Hong, Baek Jong-Beom, Miller Gary W, Pennell Kurt D | eng | R01 ES016175 (NIEHS NIH HHS, United States); T32 ES012870 (NIEHS NIH HHS, United States); R01-ES016175 (NIEHS NIH HHS, United States) | Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S. | Nanotubes, Carbon, Suspensions, Water, Quartz | IM | 22704927, S0043-1354(12)00374-0, 10.1016/j.watres.2012.05.036, PMC3395080, NIHMS388477, 19068812, 12484798, 17960610, 10649989, 15506213, 18939543, 12785531, 17265945, 19058159, 18323101, 18546694, 19924937, 17125965, 12630480, 15585362, 19650638, 15382867, 16830540, 20000506 | A series of one-dimensional column experiments was conducted to examine the effects of tube length on the transport and deposition of 4-ethoxybenzoic acid functionalized multi-wall carbon nanotubes (MWCNTs) in water-saturated porous media. Aqueous MWCNTs suspensions were prepared to yield three distributions of tube lengths; 0.02-1.3 μm (short), 0.2-7.5 μm (medium), and 0.2-21.4 μm (long). Results of the column studies showed that MWCNT retention increased with increasing tube length. Nevertheless, more than 76% of the MWCNT mass delivered to the columns was detected in effluent samples under all experimental conditions, indicating that the functionalized MWCNTs were readily transported through 40-50 mesh Ottawa sand. Examination of MWCNT length distributions in the effluent samples revealed that nanotubes with lengths greater than 8 μm were preferentially deposited. In addition, measured retention profiles exhibited the greatest MWCNT deposition near the column inlet, which was most pronounced for the long MWCNTs, and decreased sharply with travel distance. Scanning electron microscope (SEM) images showed that MWCNTs were deposited on sand surfaces over the entire column length, while larger MWCNT bundles were retained at grain intersections and near the column inlet. A mathematical model based on clean bed filtration theory (CBFT) was unable to accurately simulate the measured retention profile data, even after varying the weighting function and incorporating a nonuniform attachment rate coefficient expression. Modification of the mathematical model to account for physical straining greatly improved predictions of MWCNT retention, yielding straining rate coefficients that were four orders-of-magnitude greater than corresponding attachment rate coefficients. Taken in concert, these experimental and modeling results demonstrate the potential importance of, and need to consider, particle straining and tube length distribution when describing MWCNT transport in water-saturated porous media. | Computer Simulation, Models, Chemical, Motion, Nanotubes, Carbon, Particle Size, Quartz, Suspensions, Water | null |
22,704,929 | 2012-10-30 | 2012-07-09 | 1879-2448 | Water research | Importance of flow stratification and bubble aggregation in the separation zone of a dissolved air flotation tank. | Lakghomi B, Lawryshyn Y, Hofmann R | eng | null | Journal Article | null | IM | 22704929, S0043-1354(12)00376-4, 10.1016/j.watres.2012.05.038 | The importance of horizontal flow patterns and bubble aggregation on the ability of dissolved air flotation (DAF) systems to improve bubble removal during drinking water treatment were explored using computational fluid dynamics (CFD) modeling. Both analytical and CFD analyses demonstrated benefits to horizontal flow. Two dimensional CFD modeling of a DAF system showed that increasing the amount of air in the system improved the bubble removal and generated a beneficial stratified horizontal flow pattern. Loading rates beyond a critical level disrupted the horizontal flow pattern, leading to significantly lower bubble removal. The results also demonstrated that including the effects of bubble aggregation in CFD modeling of DAF systems is an essential component toward achieving realistic modeling results. | Air, Flocculation, Hydrodynamics, Models, Chemical, Rheology, Solubility, Water Purification | null |
22,704,928 | 2012-10-30 | 2013-11-21 | 1879-2448 | Water research | Alumina nanoparticles-induced effects on wastewater nitrogen and phosphorus removal after short-term and long-term exposure. | Chen Yinguang, Su Yinglong, Zheng Xiong, Chen Hong, Yang Hong | eng | null | Journal Article, Research Support, Non-U.S. Gov't | Sewage, Water Pollutants, Chemical, Phosphorus, L-Lactate Dehydrogenase, Aluminum Oxide, Nitrogen | IM | 22704928, S0043-1354(12)00380-6, 10.1016/j.watres.2012.05.042 | Alumina nanoparticles (Al₂O₃ NPs) have been widely used in many fields, which causes a growing concern about their potential health and environmental risks. However, their possible impacts on wastewater nitrogen and phosphorus removal have not yet been reported. In this study, both short-term and long-term effects of Al₂O₃ NPs on wastewater nutrient removal were investigated. Scanning electron microscope (SEM) analysis showed that most of Al₂O₃ NPs were adsorbed onto activated sludge, but these NPs had no adverse effects on the surface integrity and viability of activated sludge. It was found that short-term exposure to 1 and 50 mg/L Al₂O₃ NPs induced marginal influences on wastewater nitrification, denitrification and phosphorus removal. Nevertheless, the prolonged exposure to 50 mg/L Al₂O₃ NPs was observed to decrease the total nitrogen (TN) removal efficiency from 80.4% to 62.5% due to the suppressed denitrification process, although biological phosphorus removal and the transformations of intracellular polyhydroxyalkanoates and glycogen were not affected. Quantitative PCR assays indicated that compared with the control, 50 mg/L Al₂O₃ NPs decreased the abundance of denitrifying bacteria in activated sludge. Further enzyme activity tests showed that the activities of key denitrifying enzymes (nitrate reductase and nitrite reductase) were inhibited, which might be responsible for the negative effects of 50 mg/L Al₂O₃ NPs on wastewater nitrogen removal after long-term exposure. | Adsorption, Aluminum Oxide, Bacteria, Biodegradation, Environmental, Denitrification, L-Lactate Dehydrogenase, Nanoparticles, Nitrogen, Phosphorus, Sewage, Time Factors, Waste Disposal, Fluid, Water Pollutants, Chemical, Water Purification | null |
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