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SOLAR-POWERED TECHNOLOGICAL CASE
The present invention relates to a multipurpose system installed in cases, particularly suitcases, which is composed of wheels driven by an electric motor, a torch for illumination, a triangle that illuminates to warn against collision, a charger and an audio alarm device. The multipurpose system is electrically powered by means of a rechargeable battery that is charged with electricity by a panel of solar power cells as a main source of energy, or by means of any conventional electrical energy source. The system is controlled by means of a remote-control device. The invention provides people travelling with these cases with many features that may be needed, such as the feeling of safety and ease when travelling with the cases, whatever the weight and size of the cases. Older people, those with special needs, young people and those with a poor constitution can easily travel with the cases.
patent
[ [ "Climate, Energy and Mobility", "Digital, Industry and Space" ] ]
[ [ "Clean, safe and accessible transport and mobility", "Energy storage", "Energy supply", "Smart mobility" ] ]
EG 2018000032 W
Bilateral Trade and Fisheries Development: the Anglo-Danish Trade Agreement, 19331
This article examines the fish trade between Denmark and Britain, focusing on the 1933 bilateral trade agreement. Britain was the main export market for Danish fish, achieving a significant market share. Import penetration exacerbated British concerns about competitiveness that had emerged during the 1920s. While British protectionism saw the introduction of tariffs and quotas, which nominally reduced Danish imports by 10%, the Danes accommodated restrictions through exporting semi-processed fish. This article details trends in fish imports from Denmark, examines the national positions in negotiating the trade agreement, and considers how each country's fishing industry responded to its implementation. It draws two principal conclusions. First, that the significance of trade in the development of the interwar fisheries requires greater consideration in historical accounts. Second, that the Danish industry more effectively accommodated the new trade regime than the nominally protected British fishing industry.
publication
[ [ "Culture, Creativity and Inclusive Society", "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Social and economic transformations" ] ]
W2120748861
An immunological hub of excellence in porto tailored to fulfil the era priorities
The mission of an ERA Chair in Immunology (ImmunoHUB) is to create a Platform of excellence in research and innovation at IBMC-i3S (Portugal). Cancer, infectious diseases, autoimmunity and neurodegenerative disorders are major problems affecting our society. These pathologies are studied at IBMC-i3S and result in in part from deregulated immune responses, which makes Immunology a core pillar in our institute. Moreover, the successful usage of immune checkpoint blockade therapies has revolutionized the treatment of cancer and highlights the importance of understanding how to harness the Immune system for future development of vaccines or therapeutics against these diseases. Despite the contributions of our research groups for the understanding of how immune responses are orchestrated in health and disease, the international visibility of IBMC-i3S as a research center of Excellence in Immunology remains modest. The ImmunoHUB action will (1) project Immunology at IBMC-i3S towards the forefront of basic and translational biomedical research, (2) provide knowledge of fundamental and economical value, (3) promote the finest academic practices to train the next generation of Immunologists and (4) widen public awareness for the importance of Immunology. Taking advantage of our high-quality scientific, technological, administrative and governance structures, we have set a comprehensive work plan to facilitate the integration and sustainability of the ERA Chair team and the implementation of the ImmunoHUB project. Our proposal is aligned with the existing scientific policy in Portugal and with the Societal Challenges and the ERA priorities identified by the European Commission under the H2020 program. Together, these synergistic actions will play a pivotal role to equip Portugal with the cornerstone infrastructures and human resources of the highest level to reach scientific excellence in Biomedical Research across Europe.
project/european
[ [ "Health", "Culture, Creativity and Inclusive Society", "Digital, Industry and Space" ] ]
[ [ "Non-communicable and rare diseases", "Healthcare systems", "Tools, technologies and digital solutions for health and care, including personalised medicine", "Infectious diseases, including poverty-related and neglected diseases" ] ]
3735326
Development and pilot production of sustainable bio binder systems for wood based panels
The overall objective of the SusBind project is to produce and test, in an industrially relevant environment (TRL5), bio-based binders as alternative to formaldehyde based binder currently used in the production of wood-based panel board (abbreviated as wood board). A lot has been done on this subject, but so far a bio-based binder able to compete at industrial scale with incumbent chemicals, does not exist. The reason to believe on the success of this project is backed: on the selection of the partners, which involves actors across the whole supply chain, and their extensive technological background developed during the last years. The SusBind project intends to build on these success factors by: i. Selecting more adequate feedstocks from existing European Bio-refineries; ii. Applying new and greener conversion technologies for the production of binders and intermediates, including novel epoxidizing enzymes (peroxygenases) developed in the project IndOx (FP7-KBBE; www.indoxproject.eu ); iii. Producing and validating these new bio-based binders with leading wood board manufacturers for two product types: P2 Particle Board (PB) and Medium Density Fibreboard (MDF) and; iv. Involving the world leading brand owner, producer and retailer of mass market furniture. The SusBind resulting binder system will prove better performance in PB and MDF in terms of 50 - 75% reduction of formaldehyde emissions than current fossil- and formaldehyde-based wood boards. The active participation of industry and a consumer brand owner secures post-project scale up into existing plants. On the basis of cost analyses performed, an economically viable and better performing precursor will increase the marketability of bio-based furniture products concerned. The results of SusBind will not only benefit consumer health and help mitigate climate change, but also strengthen the European furniture industry by providing a cost efficient, bio-based alternative to formaldehyde-based binders.
project/european
[ [ "Health", "Climate, Energy and Mobility", "Digital, Industry and Space", "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Climate science and solutions", "Buildings and industrial facilities in energy transition", "Energy supply" ] ]
889415
The antidepressant agomelatine reduces fear long term memory but not acquisition or short term expression of fear memories
Alterations in fear learning processes may be implicated in mood disorders. Fear learning has been investigated with Pavlovian classical fear conditioning paradigms, consisting of pairing a neutral conditioned stimulus (CS), such as a tone, with an aversive unconditioned stimulus (US), such as a footshock. Upon subsequent exposure, the CS is perceived as aversive and provokes a fear response.The novel antidepressant agomelatine acts as a melatonergic receptor agonist and a 5-HT 2C receptor antagonist. Its antidepressant action was demonstrated in preclinical and clinical studies. Agomelatine has also anxiolytic properties. The aim of this study was to determine how acute agomelatine treatment might differentially alter fear circuits by using auditory fear conditioning in the rat.A single pre-training injection of agomelatine (40 mg/kg intraperitoneally) significantly reduced freezing to the fear arousing CS 24 hours after training but not during training or 3 hours after training. This pattern of results is consistent with an effect on the consolidation of the fear memory. A single pre-testing injection of agomelatine had no effect on conditioned fear expression. These effects of agomelatine should be considered in relation to its antidepressant action. Agomelatine achieved a reduction of fear conditioning in a single dose, while classical SSRIs only reduced fear conditioning after chronic treatment. This finding is consistent with clinical studies suggesting a faster onset of action of agomelatine than classical SSRI treatment.
publication
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases" ] ]
W2061585419
Design Interface Management of Airport Projects
AbstractInterface management is the brainchild of project management, which gives a “bird’s eye view” and helps to avoid time overruns, reduces the cost overruns, mitigates the reworks in construction and also gains intangible benefits like customer satisfaction. The 3D modeling and design structure matrix (DSM) method have been the preferred solutions for interface management in the construction industry for some time. But for airport construction, which consists of a huge number of services, it is difficult to carry out interface management with the above methodologies, as it would be time consuming and costly. So, a new project management methodology has been proposed which deals with preparation of a physical interface matrix (PIM) and design interface management matrix (DIMM) from the 2D coordinated drawings, by which one can reduce the problem size and then perform 3D modeling. This leads to visualization of the actual interface problems so they can be mitigated during the design stage itself. This ...
publication
[ [ "Digital, Industry and Space", "Civil Security for Society" ] ]
[ [ "Key digital technologies", "Manufacturing technologies" ] ]
W1987548270
Strategies to adapt to climate change in Adriatic regions
The project aims at empowering local policy-makers to enable climate-smart governance approaches and promote sustainable living in Adriatic marine and coastal areas. RESPONSe will provide the tools to foster effective policy-making on climate adaptation at local level and support strategic decision-making on how best to address the effects of climate change on the coastal areas of the Adriatic basin. Building on the development of tailored climate services tackling vulnerabilities of the Adriatic region, RESPONSe will promote the engagement of local policy-makers and help mainstreaming adaptation planning into policy frameworks.
project/regional
[ [ "Climate, Energy and Mobility" ] ]
[ [ "Climate science and solutions", "Communities and cities", "Energy systems and grids" ] ]
interreg_3015
DRILLING DIRECTION CORRECTION OF A STEERABLE SUBTERRANEAN DRILL IN VIEW OF A DETECTED FORMATION TENDENCY
A method for causing a desired drilling direction of a steerable subterranean drill in consideration of a contemporaneously detected formation tendency force acting on a drill bit of the steerable subterranean drill. The method includes detecting, utilizing a steering direction setting device, a direction and magnitude of a formation tendency force acting on the drill bit of the steerable subterranean drill. Further the steering direction setting device is configured to contemporaneously cause the drill bit of the steerable subterranean drill to drill in the desired direction, counteracting the formation tendency force based on the detected direction and magnitude of the formation tendency force acting on the drill bit.
patent
[ [ "Digital, Industry and Space" ] ]
[ [ "Emerging enabling technologies", "Manufacturing technologies" ] ]
US 2014/0066349 W
A review of robotic mechanisms for ultrasound examinations
Purpose – This paper aims to review the mechanical characteristics of the robotic mechanisms developed for ultrasound examinations. This will help to extract those mechanical features which together can produce a design with superior functionality. Design/methodology/approach – Following an introduction regarding ultrasound examination, this paper discusses the concept of robotic ultrasound imaging and classifies the mechanisms in terms of their power trains used for robotic and haptic devices which assist physicians to perform ultrasound imaging on patients. A set of mechanical characteristics which together can generate a superior design is also presented. Findings – The present paper shows that the robotic devices developed so far can perform ultrasound examinations. Each design with its own advantageous characteristics, and their simultaneous implementation in a new design, will create a robotic device with improved performance. Originality/value – This paper provides a detailed review of the developments of the robotic systems for ultrasound examinations and some guidelines for new designs with improved functionality.
publication
[ [ "Health", "Digital, Industry and Space" ] ]
[ [ "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
W2068959882
Cell-based therapies for Huntington's disease
Cell-based therapies are a viable option for the long-term treatment of Huntington's disease (HD), which is characterized by progressive neurodegeneration predominately in the striatum and cortex. Current research focuses on genetic suppression of the mutant huntingtin (mHTT) gene and cell replacement therapy of the lost cells in HD. As we discuss here, the recent development of induced pluripotent stem (iPS) cells technology demonstrated the potential of cell-based therapy in rodent models. It was shown that iPSCs were capable of differentiating into lost neurons in HD and stem cell grafts can improve motor deficiency in HD rodent models. Altogether, these findings have shown great promise for developing the foundation of the cell-based therapy.
publication
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases" ] ]
W1981471255
Sailing to Byzantium and Byzantium of W. B. Yeats – A Symbolical Viewpoint According to the Creation of Primal Elements
Two well-known poems of W. B. Yeats are seen here in a specific perspective of Creation primal elements (earth, water, air, fire) by a symbolical point of view. Certainly, there are different interpretations of these poems, where symbolic point of view is fundamental. The very symbols which interpretation/ analyses focus on are sailing (travelling) and city (Byzantium). Through our interpretation we use to move forward: There is a fore text according to which author uses to construct/create a poem, being and feeling himself as a creator (author). According to this creative thought he move structurally and mentally travelling (sailing) to the city of a mystical significance, Byzantium (New Jerusalem) through which he try to evoke symbolically/poetically Revelation and be part elementarily with Creation of Bible, that is to say: he creates a poetry with a the creation/poetry aim to be structurally and ideally well ordered and harmonized as Creation is. In this point of view the Creation is as a fore text, structurally and symbolically organized, perfectly as it is a work of God. Moving through this perspective and seeing the creation as a work of Creation, aiming to be part of, it is the perplexity of the poet himself as a creator, maker (poet). This interpretation points out the interrelation of a poet (maker, creator) with the Creator/ God and the poesy (making, creation) with Creation and the role of the quest for the poet, symbolically expressed through a journey. DOI: 10.5901/ajis.2012.v2n4p223
publication
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Culture, cultural heritage and creativity" ] ]
W2015509135
Achieving complex collaborative missions via decentralized control and coordination of interacting robots
Imagine a scenario where multiple robots have been deployed to provide services such as object handling/transportation, or pickup and delivery operations. In such a context, different robots with varying capabilities must be coordinated in order to achieve various multi-tasking procedures. Thus, the effective supervision and coordination of the overall heterogeneous system mandates a decentralized framework that integrates high-level task-planning, low-level motion control and robust, real-time sensing of the robots’ dynamic environment. Current practice is at a great deal based on offline, centralized planning and related tasks are usually fulfilled in a predefined manner: this does not utilize the capabilities of the system to operate efficiently in a dynamic environment. In most cases, sudden changes in the environment, the type of tasks, and the need for coordination, would cause the system to halt, ask for human intervention and restart. Despite the fact that public facilities are in some degree prestructured, the need for a framework for decentralized, real-time, automated task (re)-planning is evident in a twofold manner: (i) it will pave the way to an improved use of resources and a faster accomplishment of tasks inside public facilities and workspaces with high social activity; (ii) it will make an important contribution towards the vision of more flexible multirobot applications in both professional or domestic environments, also in view of the “Industry 4.0” vision and the general need to deploy such systems in everyday life scenarios. Within Co4Robots our goal is to build a systematic methodology to accomplish complex specifications given to a team of potentially heterogeneous robots; control schemes appropriate for the mobility and manipulation capabilities of the considered robots; perceptual capabilities that enable robots to localize themselves and estimate the state of the dynamic environment; and their systematic integration approach.
project/european
[ [ "Digital, Industry and Space" ] ]
[ [ "Key digital technologies", "Artificial intelligence and robotics", "Emerging enabling technologies" ] ]
216360
Unterstützung der Finanzierung von Betriebskapital im Hinblick auf die Verschlechterung der Lage des Unternehmens infolge der COVID-19-Pandemie
Das Projekt zielt darauf ab, die Aufrechterhaltung der wirtschaftlichen Tätigkeit eines Unternehmens zu unterstützen, das sich aufgrund des Ausbruchs der COVID-19-Pandemie in einer Situation plötzlicher Engpässe befunden hat. Der Antragsteller beantragt Finanzhilfen zur Finanzierung des Betriebskapitals und zur Deckung der Kosten für die Durchführung von Tätigkeiten für einen Zeitraum von drei Monaten.
project/regional
[ [ "Civil Security for Society" ] ]
[ [ "Disaster-resilient societies" ] ]
Q2703272
Foreword. The Knowledge Economy: The Present Future
All the statistics and evaluations show that the Knowledge Economy is our future. However, a close look at the developed economies demonstrates that the Knowledge Economy is already here, shaping our present time. Although there are many definitions of this new economic framework, their core content stresses the importance of data, information, and knowledge in the production of goods and delivering services in creating value for society. For instance, Powell and Snellman (2004, p.1999) define the knowledge economy as “production and services based on knowledge-intensive activities that contribute to an accelerated pace of technical and scientific advance, as well as a rapid obsolescence. The key component of the knowledge economy is a greater reliance on intellectual capabilities than on physical inputs or natural resources”. In the knowledge economy, knowledge becomes a strategic resource (Davenport & Prusak, 2000; Nonaka & Takeuchi, 1995) and knowledge strategies contribute directly to the competitive advantage (Bratianu & Bolisani, 2015). In this new economy, data, information, and knowledge are the driving forces of development and the knowledge economy is the engine of the global economy growth...
publication
[ [ "Culture, Creativity and Inclusive Society", "Digital, Industry and Space" ] ]
[ [ "Key digital technologies" ] ]
W2776796393
Análise das métricas dos sistemas lacustres não fluviais do Lavrado, região nordeste do Estado de Roraima
Este estudo descreve os aspectos morfométricos e a dinâmica sazonal dos sistemas lacustres situado no Lavrado, porção nordeste de Roraima. A metodologia para identificar os sistemas lacustres foi realizada através de classificação supervisionada com base em imagens Landsat 8 (OLI) de 2014 (período chuvoso) e 2015 (período de estiagem). A morfologia dos lagos permanentes e temporários foi caracterizada através do índice de forma, que é uma correlação entre o perímetro do lago e a geometria de um círculo de igual área. Modelos digitais de elevação da SRTM foram utilizados para caracterizar o ambiente regional. Os lagos do lavrado desenvolvem-se em cotas entre 50 a 200 metros de altitude, em regiões onde predominam feições morfológicas agradacionais. Os lagos foram classificados como de nascentes, isolados ou conectados. Em relação à morfologia, os lagos são predominantemente circulares e semicirculares nas duas estações do ano. No período das chuvas os lagos formam um sistema interconectado entre si e também aos sistemas fluviais (conectividade flúvio-lacustre), ocupando área de 832,62 km2; durante a estiagem a área deste sistema lacustre é de 129,25 km2, constituindo 17.000 lagos entre os perenes e sazonais.
publication
[ [ "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Seas, oceans and inland waters", "Biodiversity and natural resources", "Environmental observation" ] ]
W4283788613
Expression and Function of Ephrin-B1 and Its Cognate Receptor EphB2 in Human Abdominal Aortic Aneurysm
We examined the expression of ephrin-B1 and its cognate receptor EphB2, key regulators of angiogenesis and embryogenesis, in human abdominal aortic aneurysm (AAA) and analyzed their functional roles in cell migration. From 10 patients (9 males and 1 female; age, 68.5 ± 2.4) who underwent vascular surgery for AAA, we obtained AAA and adjacent control tissues. Using real-time RT-PCR, we analyzed expression of ephrin-B1 and EphB2. We also histologically localized these molecules in AAA tissues. Finally, effects of ephrin-B1 and EphB2 on inflammatory cell chemotaxis were examined by cell migration assay. Expression levels of ephrin-B1 (0.410 ± 0.046 versus 1.198 ± 0.252, P = 0.027) and EphB2 (0.764 ± 0.212 versus 1.272 ± 0.137, P = 0.594) were higher in AAA than normal control. Both ephrin-B1 and EphB2 were expressed in macrophages, T lymphocytes, and endothelial cells within AAA. In chemotaxis assay, ephrin-B1 and EphB2 inhibited mononuclear-cell chemotaxis induced by stromal derived factor-1 down to 54.7 ± 12.7% (P = 0.01) and 50.7 ± 13.1% (P = 0.01), respectively. These data suggest that ephrin-B1 and EphB2 might be functional in human adult inflammatory cells and involved in the pathogenesis of AAA, although specific roles of these molecules should further be sought.
publication
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases", "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
W2135230201
Investigation of the charge-transfer in photo-excited nanoparticles for CO2 reduction in non-aqueous media
Photoinduced charge separation in TiO2 and Cu2O semiconductor nanoparticles was examined using Electron Paramagnetic Resonance spectroscopy in order to get insight into the photocatalytic reduction of CO2 in nonaqueous media. For dissolution/grafting of CO2 we have used carboxy-PEG4-amine, and as a solvent poly(ethylene glycol) 200. We have found that, in this system, reduction of CO2 starts at potential of -0.5 V vs Ag/AgCl, which is significantly more positive than the potential for electrochemical reduction of CO2 in most organic solvents and water (-2.0 V vs. Ag/AgCl). The electron transfer from excited nanoparticles to CO2 is governed both by thermodynamic and kinetic parameters, namely by the redox potential of conduction band electrons and adsorption/binding of CO2 on the surface of nanoparticles.
publication
[ [ "Climate, Energy and Mobility", "Digital, Industry and Space" ] ]
[ [ "Climate science and solutions", "Energy supply" ] ]
W2125440809
What does it mean to be heterosexual?
What does mean to be heterosexual? How do you know if you are heterosexual? Though much research has investigated what it means to be *homosexual* very little empirical research has investigated the meaning of heterosexuality. Furthermore, most people who consider themselves heterosexual have never given this question much thought. However, a number of recent, tragic events (e.g., the murder of Gwen Araujo and the deadly attack by Omar Mateen) show that our perceptions of heterosexuality can have profound ramifications for our self-image and our treatment of transgender individuals, gay men and lesbians. My prior research has pointed to two lay models of heterosexuality that can have important consequences for anti-LGBT prejudice – a model of heterosexuality as a form of biological-purity and a model of heterosexuality as a form of moral purity. Across 14 studies (4 large-scale, representative surveys in multiple countries, and 10 lab-based genuine experiments), this proposed research will verify the biological-purity and moral-purity models of heterosexuality, identify the predictors and associated consequences of these models (Studies 1 – 4), investigate the consequences of the biological-purity model for anti-transgender prejudice (Studies 5 – 7), investigate the consequences of the moral-purity model for anti-gay prejudice (Studies 8 – 12), and investigate whether and how individuals strategically adopt or abandon these models to preserve their values and self-image (Studies 13 – 14). Together, these studies will add meaningfully to our theoretical understanding of sexual orientation and some of the causes of anti-gay and anti-transgender prejudice. On a practical level, they will point to new ways of combating anti-LGBT prejudice, even in some of the most severely prejudiced societies, and have implications for a number of real-world issues such as legal protection and gay conversion therapy.
project/european
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Social and economic transformations", "Democracy and Governance", "Culture, cultural heritage and creativity" ] ]
225689
Complex oscillatory systems: modeling and analysis
Many natural and artificial systems are often composed of oscillatory elements which, besides evolving according to their own non-trivial internal dynamics, mutually interact. As a result, many temporal and spatial scales are typically present, often accompanied by the spontaneous emergence of collective properties. Altogether, such features make the task of understanding the resulting evolution a challenging interdisciplinary problem. Zero-knowledge methods do generally require too large amount of data to allow drawing meaningful conclusions. In order to overcome this limitation, it is necessary to add skilful hypotheses about the structure of the underlying model and, thereby, on the relevant variables. This task is often tackled in an ad hoc way and the approach is based rather on personal preferences than on objective elements. The goal of this project is to fill the gap, by developing a general and coherent set of tools for the system identification and control, as well as to improve our ability to make predictions. The task will be pursued by combining top-down with bottom-up approaches which will be used to identify the most appropriate variables. Such analysis will be integrated by performing suitable case studies and mutually validating the various techniques to test the correctness of the underlying assumptions (both in the context of theoretical models as well as in experimental time series, such as physiological and neural data). A user-friendly software package will be ultimately developed to make the methods accessible to a broad set of potential users, including those with minimal theoretical competences. Furthermore, we will train a new generation of scientists able to implement a broad range of interdisciplinary approaches to the multivariate time signals that may be generated by the evolution of complex systems.
project/european
[ [ "Digital, Industry and Space" ] ]
[ [ "Advanced computing and big data", "Emerging enabling technologies" ] ]
169983
Gpcr exploitation to unlock the power of brown/beige adipose tissue
Hundreds of millions of people suffer from obesity and diabetes worldwide. These diseases diminish both life quality and expectancy and new treatment strategies are desperately needed. One possible approach is to target the calorie-burning and glucose-consuming functions of brown and beige adipose tissue (B/BAT). Previous attempts to harness the therapeutic potential of B/BAT have largely focused on the β-adrenergic class of G protein-coupled receptors (GCPRs). Unfortunately, these methods are hindered by adverse cardiovascular side effects linked to adrenergic activation. Therefore, uncovering non-adrenergic alternatives to exploit B/BAT for treating metabolic disease holds the potential for enormous societal and economic benefit. Here, we propose the activation of one such non-adrenergic GPCR on B/BAT as a means to treat obesity and diabetes. We identified this GPCR from a screen of B/BAT receptors performed in my ERC Starting Grant project, aCROBAT. We found that treating brown adipose cells with the peptide ligand for this GPCR increased oxygen consumption. We recognized the therapeutic potential after observing that ligand administration in vivo lowered bodyweight and improved insulin sensitivity in obese mice. However, the resources required to develop this discovery into a tangible innovation extend beyond the scope of aCROBAT. Consequently, I’m applying for an ERC PoC grant for critical support to take the initial steps to commercial application. Specifically, we seek to strengthen our IP position by developing patentable, longer-lived analogues of the ligand. Importantly, we will test these lead compounds head-to-head and in combination with current treatment options. We have assembled a team of experts to address key aspects from peptide design and pharmacology to IPR strategy and commercial development. Combined with our validated in vitro and in vivo testing platforms, we are ideally poised to maximize innovation potential.
project/european
[ [ "Health", "Digital, Industry and Space" ] ]
[ [ "Health throughout the life course", "Tools, technologies and digital solutions for health and care, including personalised medicine", "Non-communicable and rare diseases" ] ]
223964
Globalization and a dual Europe: future alternative growth trajectories
The integration of world markets has increased considerably in the past 15 years. Moreover, the importance of emerging countries for trade flows is now considerably higher. The paper explores the question of what the European territory will look like over the next fifteen years under different assumptions on competitive strategies put in place by the so-called BRIC countries (Brazil, Russia, India and China). In these scenarios Europe is expected to reinforce its present competitive advantages. The intention is not to identify desirable, positive, ideological or most probable scenarios; the aim is instead to combine in a strictly logical way the different trajectories that can be envisaged in the main economic, institutional and social driving forces of change and consequently to build a small number of alternative, consistent and ‘conditional’ scenarios. The approach is as neutral as possible vis-a-vis the results, leaving it to the MASST forecasting model to provide NUTS 2 growth rate patterns up to 2015, under opposite assumptions on the world strategies.
publication
[ [] ]
[ [] ]
W1972724210
Design and Implementation of In-Circuit Programming for Flash Memory in HCS08 MCU Family
On the basis of analysis of the characteristics of flash memory in HCS08 MCU family, how to perform program and erase operations are demonstrated during in-circuit programming of flash memory in HCS08 MCU family. In order to solve the unstable problem during in-circuit programming of flash memory, three methods are put forward. After studying on the features of the three methods, the implementation of the methods is given. During the debugging, MC9S08AW60 MCU is chose to verify the feasibility of the methods, and the experiment experience is supplied. The paper plays an importance role in in-circuit programming of flash memory in HCS08 MCU family.
publication
[ [ "Digital, Industry and Space" ] ]
[ [ "Key digital technologies", "Manufacturing technologies" ] ]
W1972178730
[Knowledge on stroke in Spanish population. A systematic review].
To analyze by means of a systematic review the general knowledge about strokes of the Spanish population.A systematic review is performed following PRISMA guidelines and with data from PubMed, Scopus and EMBASE. All studies carried out in Spain, centred around the knowledge of strokes are compiled (terminology, pathophysiology, signs and symptoms, risk factors, treatment, and willingness to make use of the Emergency Services). From the 4,627 articles collected, 21 were ultimately included in this review.In Spain, the term stroke is less known than others such as embolism or cerebrovascular accident. Loss of strength is the most widely recognized symptom, whereas arterial hypertension is the most widely identified risk factor. The least known symptom and risk factor are visual impairment and diabetes mellitus, respectively. When faced with a suspected stroke, the attitude of most respondents is adequate as they decide to go to the hospital or call the Emergency Services. However, in rural areas or in cases in which the symptoms suddenly stop, a greater number of participants choose to go to their family physician. The main sources of information of the participants are their family members and their doctors.General knowledge about strokes is scarce among the general population. Nonetheless, the attitude of most of the participants is adequate as they choose to contact specialized Emergency Services.Conocimiento sobre el ictus en la población española. Una revisión sistemática.Objetivos. Analizar mediante una revisión sistemática el estado de conocimiento sobre el ictus en la población española. Materiales y métodos. Se ha llevado a cabo una revisión sistemática siguiendo las directrices PRISMA en las bases de datos PubMed, Scopus y EMBASE. Se incorporaron todos los estudios realizados en España que versaran sobre el conocimiento del ictus (terminología, fisiopatología, síntomas y signos, factores de riesgo, tratamiento e intención de acudir a servicios de emergencias). Se identificaron 4.627 artículos, de los cuales 21 se incluyeron finalmente en la revisión. Resultados. El término ictus es menos reconocido que otros, como embolia o infarto cerebral. La pérdida de fuerza es el síntoma más reconocido y la hipertensión arterial es el factor de riesgo más identificado. El síntoma y el factor de riesgo menos reconocidos son los déficits visuales y la diabetes mellitus, respectivamente. Ante la sospecha de ictus, la actitud de la mayoría de los encuestados es adecuada, ya que eligen acudir al hospital o llamar a los servicios de emergencias. Sin embargo, en el medio rural, y ante síntomas que ceden espontáneamente, un mayor número de participantes elige acudir a su médico de familia. Las principales fuentes de información de los participantes son sus familiares y médicos. Conclusiones. El conocimiento global sobre el ictus es escaso entre la población española. Sin embargo, la actitud de la mayoría de los participantes es adecuada, ya que elige mayoritariamente contactar con servicios de emergencias especializados.
publication
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases", "Health throughout the life course", "Healthcare systems" ] ]
W4220799749
Positive Posterior Margin of Needle Biopsy Cores Is an Independent Predictor for Extracapsular Extension in Retropubic Radical Prostatectomy
To introduce the new preoperative parameter as a predictor for extracapsular extension (ECE), we defined the presence of tumor at the stump of the rectum side on prostate needle biopsy as a positive posterior margin (PPM), and speculated that PPM is related to ECE.This retrospective study was conducted in 230 patients who underwent prostate needle biopsy and retropubic radical prostatectomy between 2001 and 2011. We analyzed the association between their clinicopathological parameters and ECE.Multivariate analysis showed that the Gleason score (P = .023, odds ratio [OR] 1.433), serum prostate-specific antigen (PSA, P = .013, OR 1.040), clinical stage (P = .018, OR 2.162), and PPM (P = .013, OR 2.253) were significant independent predictors for ECE. Next, using these 4 preoperative risk factors, we were able to accurately predict their ECE. Patients with 0 or 1 risk factor had a low probability of ECE (13.0% and 18.5%, respectively). In contrast, the majority of patients who had 3 or 4 risk factors were found to have ECE (80.1% and 71.4%, respectively).The data suggest that the Gleason score, serum PSA, clinical stage, and PPM may be independent predictors for the existence of ECE. This suggests that the posterior margin in biopsy specimens is a more reliable and clinically useful parameter when making decisions concerning the choice of treatments.
publication
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases", "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
W2021787070
Synthesis of delafossite CuAlO2 p-type semiconductor with a nanoparticle-based Cu(I) acetate-loaded boehmite precursor
Abstract Delafossite CuAlO2 p-type nanostructured semiconductor was synthesized using boehmite (γ-AlOOH) nanorods loaded with copper(I) acetate [Cu(OAc)] as a precursor (nanoprecursor). Because Cu(OAc)-loaded γ-AlOOH nanorods are highly anisotropic, they tend to form inherent bunches consisting of several nanorods during the course of drying the nanoprecursor dispersion droplet on a solid substrate. By annealing the nanoprecursor at 1150 °C in air, a delafossite CuAlO2 polycrystal was successfully obtained as the dominant phase. The CuAlO2 polycrystal is found to exhibit the (1 1 0) crystal orientation. The crystalline anisotropy of CuAlO2, which is not usually attainable using conventional molecular precursors, is presumably originated in the anisotropic morphology of the nanoprecursor. The Seebeck coefficient, resistivity and thermal conductivity of the CuAlO2 polycrystal at 300 K were found to be +560 μV K−1, 1.3 Ω m and 19.4 W K−1 m−1, respectively, confirming the p-type nature of the CuAlO2 polycrystal.
publication
[ [ "Digital, Industry and Space" ] ]
[ [ "Advanced Materials" ] ]
W2032274185
Spatiotemporal Evolution of Specialized Villages and Rural Development: A Case Study of Henan Province, China
Regional economic development is inherently uneven as determined by the local conditions and available resources. Specialized villages (SVs) in China played a very important role in the development and economic transformation in rural areas. By integrating regional spatial structure theory, multilevel network theory, and spatial interface theory, this article examines the spatial and temporal evolution of SVs in Henan Province, China. Results from the analyses show that the development of SVs over time progressed in four stages, each corresponding to important adjustments in national agricultural policy. SVs were distributed unevenly in space and the distribution seemed to be scale-dependent. At a macrolevel, SVs displayed a dispersed pattern over a large area. SVs showed localized clusters at a microlevel, however, also exhibiting a core–periphery structure. Rural economic development in China showed that SVs formed a multilevel network hierarchy. We also observed that SVs were often in transitional area...
publication
[ [ "Culture, Creativity and Inclusive Society", "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Social and economic transformations", "Culture, cultural heritage and creativity" ] ]
W2216194352
Pericyte-Derived tumor stroma – a target for cancer therapy
Cancer is a devastating diagnosis since treatments to prevent a lethal outcome are limited. Tumor constitutes a complex tissue consisting of malignant cells and stromal cells. Emerging studies have shown the importance of stroma in tumor growth, invasion, and metastasis highlighting its potential as an attractive target for cancer therapy. However, the source of tumor stroma generating cells remains elusive. Generation of connective tissue is a general feature of scarring and fibrosis. While scarring is part of the wound healing response, fibrosis represents a failure to terminate tissue repair. In this context, tumors can be considered as “wounds that do not heal”. While studying spinal cord injury-induced scarring, a subpopulation of perivascular cells, type A pericytes, has been shown to be a major source of the stromal scar. Type A pericytes are embedded in the vascular wall but proliferate and leave blood vessels upon injury, differentiating into fibroblast-like cells that deposit extracellular matrix and form the stromal scar. Here, I propose to determine whether type A pericytes are a source of tumor stroma and whether blocking type A pericyte-derived stroma formation can impede cancer progression. Single cell studies to determine pericyte heterogeneity within malignant and non-malignant tissue will be performed. This characterization of heterogeneity is important to distinguish stroma-forming pericytes from the non-forming ones and from tumor cell-derived pericytes as described in Glioblastoma multiforme (GBM). Furthermore, by using combinations of pericyte reporter mice with genetic tools to manipulate pathways regulating cell proliferation and recruitment within specific pericyte subpopulations, I aim to investigate underlying mechanisms mediating pericyte-derived stroma generation. Studying stroma formation using the GBM mouse model, the proposed research intends to uncover common mechanisms of tumor stroma formation and identify new targets for therapy.
project/european
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases" ] ]
171212
Study and Valorisation of Archaeological Sites of the Mediterranean Area
The project MED.ARCHEO.SITES foresees the possibility to activate a set of different operations for the establishment of a route of knowledge, valorisation, fruition and dissemination of Cultural Heritage within a sustainable development of the cities and territories. This project is based on the fact that in all Mediterranean countries there is an enormous archaeological, architectural and artistic heritage which is not catalogued and about which very little is known. This often leads to this heritage not being preserved as it should be and it being only partially enhanced as an important historical element of the community or as a point of attraction and culture for the increasing number of tourists visiting the area. This programme deals with the problems connected to the scarce knowledge of the cultural patrimony and with the need for preserving, enhancing and promoting the same with a view to their potential exploitation by a wider range of users. The project envisages the realisation of an interlinked series of events to be carried out in several areas of southern Italy and Sicily, Greece, the island of Malta and Libya. The precise objectives of these events are to create georeferenced databanks of the historical heritage, to organise the structural preservation of archaeological and monumental complexes, to set up archaeological sites furnished with infrastructures, learning/didactic centres and other facilities and, in conclusion, to divulge the knowledge acquired to an ever vaster public. The partners involved make up part of a complementary group of subjects, working together in synergy. They are represented by spatial management organisations (Province of Vibo Valentia and Province of Salerno), research institutes (Universities of Palermo and Salerno), tourist information centres (ATEDA of Athens), local government bodies (Municipality of Athens and Municipality of Gortyna), and cultural heritage agencies (National Cultural Heritage Agency of Malta, Iben Alathir Association of Libya and Ephorate of Patras). Each partner will work in a different context (Archaeological park of Vibo Valentia; Fratte; Poseidonia/Paestum; Pontecagnano; Himera, Sicily; Gortyna, Crete; Athens, Malta, northern Peloponnisos; Libya), but will act along common guidelines established during the periodical meetings. The main activities foreseen, in logical and operative sequence, are: the cataloguing of the heritage in the various regions and ancient cities; the study of several monumental complexes or areas with a view to their enhancement; actions on archaeological structures and areas with a view to their restoration and requalification, the creation of infrastructural networks, the setting up of didactic centres, making archaeological areas into museums or the creation/reinstatement of museum spaces; meetings for presenting, divulging the results, the creation of websites and illustrative and informative brochures. The most important results expected are the creation of urban and regional catalogues including the archaeological, architectural and artistic patrimony, the detailed study of several archaeological and monumental complexes, the creation of equipped archaeological parks, the opening of new museum spaces, an improved exploitation of several archaeological sites, and a wider divulgation of the knowledge acquired regarding the relative cultural heritage. The project’s deliverables include georeferenced and computerised databanks in standard software formats (GIS), scientific and informative publications, permanent infrastructures, multi-medial products for divulging knowledge, websites. The direct beneficiaries of the project are the populations of the Mediterranean and European regions: both those residing in the areas involved in the activities who can make a better use of the newly-enhanced historical and cultural heritage, and those from other geographical regions, i.e. tourists to the Mediterranean areas who are particularly interested in the qualitative and quantitative development of knowledge and the exploitability of the heritage.
project/regional
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Culture, cultural heritage and creativity" ] ]
interreg_2217
Perspectives for the aeronautical research in europe
The overall objective of PARE (Perspectives for the Aeronautical Research in Europe) is to trigger collaboration between European stakeholders to support the achievement of the Flightpath 2050 goals, by providing yearly reports (and respective methodology) that assess the progress, gaps and barriers and propose suitable measures to close the remaining gap. The main outputs of PARE are three yearly reports on the “Perspectives for Aerospace Research in Europe” that use specific benchmarks to assess the progress towards each of the 23 Flightpath goals and the gap remaining. The assessment includes EU projects (Clean Sky, SESAR and others), national projects, academic and industrial research reports. Aspects like long-distance travelling and relevant emerging technologies from non-aeronautical sectors are focused, as well as greater participation from recent EU member states (e.g. in Eastern Europe) and associated countries (e.g Ukraine). The activities of Europe’s competitors (e.g. the U.S.) are also considered in PARE to assess: areas of EU leadership to be exploited; areas requiring specific effort in the EU to catch-up; areas of common interest for cooperation. PARE will contribute to fulfil the “Mobility for Growth” workprogramme with an assessment of progress in aerospace research, gaps and bottlenecks. The comprehensive yearly report (RC), can originate a public version (RP) and specific versions for academy and research (RA), industry, airlines and airports (RB) and certification authorities, international and professional associations (RC). The wide dissemination of each report will allow to collect feedback to improve the next one thus establishing the final reporting procedure that could be extended beyond the end of the project. Also addressed is the attraction of young talent and the increase in the participation of woman in aerospace including the preparation of a newsletter on exciting and attractive developments in aeronautics.
project/european
[ [ "Digital, Industry and Space" ] ]
[ [ "Net-zero and less polluting Industries", "Next generation internet", "Emerging enabling technologies", "Space, including Earth observation" ] ]
223485
Detection of latent fingerprints using high-resolution 3D confocal microscopy in non-planar acquisition scenarios
In digitized forensics the support of investigators in any manner is one of the main goals. Using conservative lifting methods, the detection of traces is done manually. For non-destructive contactless methods, the necessity for detecting traces is obvious for further biometric analysis. High resolutional 3D confocal laser scanning microscopy (CLSM) grants the possibility for a detection by segmentation approach with improved detection results. Optimal scan results with CLSM are achieved on surfaces orthogonal to the sensor, which is not always possible due to environmental circumstances or the surface's shape. This introduces additional noise, outliers and a lack of contrast, making a detection of traces even harder. Prior work showed the possibility of determining angle-independent classification models for the detection of latent fingerprints (LFP). Enhancing this approach, we introduce a larger feature space containing a variety of statistical-, roughness-, color-, edge-directivity-, histogram-, Gabor-, gradient- and Tamura features based on raw data and gray-level co-occurrence matrices (GLCM) using high resolutional data. Our test set consists of eight different surfaces for the detection of LFP in four different acquisition angles with a total of 1920 single scans. For each surface and angles in steps of 10, we capture samples from five donors to introduce variance by a variety of sweat compositions and application influences such as pressure or differences in ridge thickness. By analyzing the present test set with our approach, we intend to determine angle- and substrate-dependent classification models to determine optimal surface specific acquisition setups and also classification models for a general detection purpose for both, angles and substrates. The results on overall models with classification rates up to 75.15% (kappa 0.50) already show a positive tendency regarding the usability of the proposed methods for LFP detection on varying surfaces in non-planar scenarios.
publication
[ [ "Civil Security for Society" ] ]
[ [ "Cybersecurity", "Protection and security" ] ]
W2008295982
HIGH EFFICIENCY SOLAR PANEL
One embodiment of the present invention provides a solar panel. The solar panel includes a plurality of subsets of solar cells. The solar cells in a subset are coupled in series, and the subsets of solar cells are coupled in parallel. The number of solar cells in a respective subset is sufficiently large such that the output voltage of the solar panel is substantially the same as an output voltage of a conventional solar panel with all of its substantially square shaped solar cells coupled in series.
patent
[ [ "Climate, Energy and Mobility", "Digital, Industry and Space" ] ]
[ [ "Energy supply" ] ]
US 2015/0010916 W
Translational approaches to disease modifying therapy of type 1 diabetes - harvesting the fruits of innodia
Building on the strong foundations of INNODIA, with its unique, Europe-wide clinical and basic research network for the study of type 1 diabetes (T1D), we propose in INNODIA HARVEST an ambitious program which aims to prevent and arrest T1D via focused objectives targeting consolidation and innovation. First, we will consolidate the INNODIA clinical network as the reference point for conducting studies to prevent or arrest T1D. We will transform our standardized clinical and bioresource platforms into a high-performance clinical trial network, running academic and industry-driven trials alongside small, mechanism-centric, biomarker-rich intervention trials to examine pathobiological pathways to T1D. INNODIA HARVEST will conduct two large studies to arrest T1D at its onset, one academia-driven, beta-cell focused (VER-A-T1D, verapamil) and one industry-driven, immune-focused (Iscalimab-study). We will exploit our original INNODIA Master Protocol allowing novel adaptive trial design to introduce combination therapies that build on complementary mechanisms. Second, we will extend our study design strategy by introducing novel biomarkers, both clinical (continuous glucose monitoring) and experimental (microbiome analysis) to deconvolute disease heterogeneity and identify new endpoints to accelerate identification of effective therapeutics. Third, we will use ‘disruptors’ in small mechanistic studies to channel innovation from clinic to basic research through a reverse immunology and reverse beta-cell biology approach. Finally, we will implement new discovery pipelines for future therapeutics, exploiting tools such as iPSC-derived islet-like cells to promote next generation target identification and drug development. As in INNODIA, the voice of people living with T1D and their families will hold a central place in INNODIA HARVEST to drive implementation of new, patient-proximal outcomes, shape our clinical trials, and bring about a meaningful change in disease perspective. A major objective of INNODIA Harvest is the execution of at least two new phase 2 trials (studying Verapamil (VER-A-T1D) or Iscalimab (CCFZ533X2207)). Considering the expected time to first patient-in as preparations for trial start can only be initiated after the start of the Action and possible fluctuating recruiting rates, due to the intercurrent COVID epidemic, there is a risk that INNODIA HARVEST will not be able to completely finalize the clinical trials, fully analyse the biomarkers collected and publish the results in the initially proposed 24 months duration. To ensure the finalization of the clinical trials and corresponding full execution of the given budget including eligibility of EFPIA in-kind contribution we propose to extend the duration of the Action from 24 to 36 months.
project/european
[ [ "Health" ] ]
[ [ "Non-communicable and rare diseases", "Healthcare systems", "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
3725807
Noninvasive mechanical ventilation : theory, equipment, and clinical applications
Interface Technology in Critical Care Settings.- Full Mask Ventilation.- Helmet Continuous Positive Airway Pressure: Theory and Technology.- Helmet Continuous Positive Airway Pressure: Clinical Applications.- Ventilatory Modes and Ventilators: Theory, Technology, and Equipment.- Pressure Support Ventilation.- Ventilators for Noninvasive Mechanical Ventilation.- Noninvasive Positive Pressure Ventilation Using Continuous Positive Airway Pressure.- Home Mechanical Ventilators.- Maintenance Protocol for Home Ventilation Circuits.- Nocturnal Noninvasive Mechanical Ventilation.- Patient-Ventilator Interactions.- Patient-Ventilator Interaction During Noninvasive Pressure-Supported Spontaneous Respiration in Patients with Hypercapnic Chronic Obstructive Pulmonary Disease.- Asynchrony and Cyclic Variability in Pressure Support Ventilation.- Carbon Dioxide Rebreathing During Noninvasive Mechanical Ventilation.- Carbon Dioxide Rebreathing During Pressure Support Ventilation with Airway Management System (BiPAP) Devices.- Carbon Dioxide Rebreathing in Noninvasive Ventilation.- New Adaptive Servo-Ventilation Device for Cheyne-Stokes Respiration.- Monitoring and Complications.- Nocturnal Monitoring in the Evaluation of Continuous Positive Airway Pressure.- Complications During Noninvasive Pressure Support Ventilation.- CHRONIC APPLICATIONS OF NONINVASIVE MECHANICAL VENTILATION AND RELATED ISSUES.- Efficacy of Continuous Positive Airway Pressure in Cardiovascular Complications of Obstructive Sleep Apnea.- Obstructive Sleep Apnea and Atherosclerosis.- Transnasal Insufflation -Ventilator Interaction During Noninvasive Pressure-Supported Spontaneous Respiration in Patients with Hypercapnic Chronic Obstructive Pulmonary Disease.- Asynchrony and Cyclic Variability in Pressure Support Ventilation.- Carbon Dioxide Rebreathing During Noninvasive Mechanical Ventilation.- Carbon Dioxide Rebreathing During Pressure Support Ventilation with Airway Management System (BiPAP) Devices.- Carbon Dioxide Rebreathing in Noninvasive Ventilation.- New Adaptive Servo-Ventilation Device for Cheyne-Stokes Respiration.- Monitoring and Complications.- Nocturnal Monitoring in the Evaluation of Continuous Positive Airway Pressure.- Complications During Noninvasive Pressure Support Ventilation.- CHRONIC APPLICATIONS OF NONINVASIVE MECHANICAL VENTILATION AND RELATED ISSUES.- Efficacy of Continuous Positive Airway Pressure in Cardiovascular Complications of Obstructive Sleep Apnea.- Obstructive Sleep Apnea and Atherosclerosis.- Transnasal Insufflation - A New Approach in the Treatment of OSAs.- Cardiopulmonary Interventions to Prolong Survival in Patients with Duchenne Muscular Dystrophy.- Noninvasive Ventilation Pressure Adjustments in Patients with Amyotrophic Lateral Sclerosis.- Noninvasive Positive Pressure Ventilation in Amyotrophic Lateral Sclerosis.- Noninvasive Mechanical Ventilation as an Alternative to Endotracheal Intubation During Tracheotomy in Advanced Neuromuscular Disease.- Noninvasive Mechanical Ventilation in Patients with Myasthenic Crisis.- Predictors of Survival in COPD Patients with Chronic Hypercapnic Respiratory Failure Receiving Noninvasive Home Ventilation.- Withdrawal of Noninvasive Mechanical Ventilation in COPD Patients with Hypercapnic Respiratory Failure.- Noninvasive Ventilation in Patients with Acute Exacerbations of Asthma.- Noninvasive Positive Pressure Ventilation During Acute Asthmatic Attack.- Noninvasive Positive Pressure Ventilation for Long-Term Ventilatory Management.- Home Ventilation for Chronic Obstructive Pulmonary Disease.- Critical Care Applications of Noninvasive Mechanical Ventilation and Related Issues.- Current Strategies and Equipment for Noninvasive Ventilation in Emergency Medicine.- Noninvasive Ventilation Outside of Intensive Care Units.- Noninvasive Positive Airway Pressure and Risk of Myocardial Infarction in Acute Cardiogenic Pulmonary Edema.- The Role of Continuous Positive Airway Pressure in Acute Cardiogenic Pulmonary Edema with Preserved Left Ventricular Systolic Function: A Preliminary Study.- Noninvasive Ventilation in Acute Lung Injury/Acute Respiratory Distress Syndrome.- Noninvasive Positive Pressure Ventilation in Acute Hypoxemic Respiratory Failure and in Cancer Patients.- Noninvasive Ventilation as a Preoxygenation Method.- Influence of Staff Training on the Outcome of Noninvasive Ventilation for Acute Hypercapnic Respiratory Failure.- The Role of Sedation.- Sedation for Noninvasive Ventilation in Intensive Care.- Use of Dexmedetomidine in Patients with Noninvasive Ventilation.- Weaning from Conventional Mechanical Ventilation and Postextubation Failure.- Extubation and Decannulation of Unweanable Patients with Neuromuscular Weakness.- Mechanically Assisted Coughing and Noninvasive Ventilation for Extubation of Unweanable Patients with Neuromuscular Disease or Weakness.- Noninvasive Positive Pressure Ventilation in the Postextubation Period.- Noninvasive Ventilation in Postextubation Respiratory Failure.- Intraoperative and Postoperative Indications for Noninvasive Mechanical Ventilation.- Intraoperative Use of Noninvasive Ventilation.- Noninvasive Ventilation in Adult Liver Transplantation.- Noninvasive Positive Pressure Ventilation in Patients Undergoing Lung Resection Surgery.- Noninvasive Mechanical Ventilation in Neonates and Children.- Equipment and Technology for Continuous Positive Airway Pressure During Neonatal Resuscitation.- Air Leakage During Continuous Positive Airway Pressure in Neonates.- The Use of Noninvasive Ventilation in the Newborn.- Nasal High-Frequency Ventilation: Clinical Studies and Their Implications.- Bubble Continuous Positive Airway Pressure.- Noninvasive Mechanical Ventilation with Positive Airway Pressure in Pediatric Intensive Care.- Home Mechanical Ventilation in Children with Chronic Respiratory Failure.
publication
[ [ "Health", "Digital, Industry and Space" ] ]
[ [ "Non-communicable and rare diseases", "Health throughout the life course", "Healthcare systems", "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
W624561870
SOURCING SYSTEM AND METHOD
One aspect of the invention is an electronic auction system. The electronic auction system comprises computer software that is operable to receive multiple parameter bids on at least one product from a plurality of vendors. The software is further operable to calculate the total cost of the product to the purchaser in response to each vendor's bid according to a total cost formula.
patent
[ [ "Digital, Industry and Space" ] ]
[ [ "Key digital technologies", "Emerging enabling technologies", "Manufacturing technologies" ] ]
US 0034022 W
Identifying the capabilities and limitations of crispr in targeting g-quadruplex forming sequences: from target recognition to gene expression regulation
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR associated proteins (Cas) have recently been at the forefront of genomic research due to their enormous potential at editing the genome with great precision and specificity. A world-wide effort is currently underway to test Cas proteins and their variants for applications geared towards genome editing for human cells. How CRISPR-Cas systems perform in editing sequences that form non-canonical DNA or RNA secondary structures or are in the vicinity of such structures is the problem we wish to pursue during the course of proposed studies. One such structure is the G-quadruplex (GQ), which has been demonstrated to form throughout the human genome, with particular concentration in telomeric sites, promoters, and 3’ and 5’ untranslated regions of RNA. The higher frequency of potentially GQ forming sequences (PQS) at such regulatory sites has suggested a potential role for these structures in transcription or translation level gene expression regulation. GQ formation has been demonstrated to inhibit gene expression for a number of different genes, including certain critical oncogenes. Inability to remove these structures is directly associated with several syndromes, including Bloom and Werner syndromes, and neurological disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Therefore, editing such sequences to prevent GQ formation also has therapeutic potential. We will design different single guide RNA constructs and target the GQ forming G-rich or the complementary C-rich strand to elucidate the capabilities and limitations of the CRISPR-Cas9 system in editing such structures using single molecule techniques and bulk assays. We will then investigate whether CRISPR-Cas9 can be used to regulate gene expression by targeting GQ structures in the promoter region of tyrosine hydroxylase and c-Myc genes in the presence and absence of GQ stabilizing small molecules.
project/european
[ [ "Health", "Digital, Industry and Space" ] ]
[ [ "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
223694
Cooperation and competition: a GIS pilot study of Taichung’s district Bookstart programme
Policy innovation and diffusion are vital for ensuring the well-being of the general public by providing the services they need. Cooperation and competition between jurisdictions are seen as important mechanisms for the diffusion of innovation. This study examines cooperation and competition in the innovation diffusion process and presents a case study of the Bookstart programme in the libraries of Taichung County, Taiwan. Using a geographic information system (GIS), it examines whether cooperation and competition are spatially dependent. The findings demonstrate that the level of cooperation is not autocorrelated with neighbouring districts, and that there are limited examples of competition. We argue the case for the use of GIS in studies of policy diffusion.
publication
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Democracy and Governance" ] ]
W2017918951
DEVICE AND METHOD FOR SOLUBILIZING, SEPARATING, REMOVING AND REACTING CARBOXYLIC ACIDS IN OILS, FATS, AQUEOUS OR ORGANIC SOLUTIONS BY MEANS OF MICRO- OR NANOEMULSIFICATION
The present invention is directed to solubilizing compounds, a device and a method for solubilizing and removing carboxylic acids and especially fatty acids from oils, fats, aqueous emulsion, aqueous media and organic solutions. Devices utilizing the inventive method shall be used for separating carboxylic acids from oils, fats, aqueous emulsion, lipophilic media or organic solutions, respectively by preparing an aqueous micro- or nanoemulsion of the carboxylic acids especially the fatty acids and the solubilizing compound which contains at least one amidino and/or gianidino group. Solubilization effects of solubilizing compounds combined with the inventive use of separation methods for carboxylic acids can be used to treat persons in need of removal of fatty acids or analyze carboxylic acids from blood or process other solutions in food, pharmacy, chemistry, bio fuel industry or other industrial processings.
patent
[ [ "Digital, Industry and Space", "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Emerging enabling technologies", "Advanced Materials", "Manufacturing technologies" ] ]
EP 2011003182 W
Gender equality in engineering through communication and commitment
GEECCO aims to establish tailor-made Gender Equality Plans (GEPs) in 4 European RPOs and to implement the gender dimension in 2 RFOs (funding schemes, programmes and review processes). All participating RPOs are located in the STEM (Science, Technology, Engineering, and Mathematics) field, where gender equality is still a serious problem and whose innovations are increasingly important in the knowledge-based economies. It is thus a question of excellence, competitiveness and justice to achieve gender equity within STEM-institutions, including policy and decision making bodies. Concerning the gender dimension in research programmes RFOs are the key to substantial changes and thus a crucial part of the aspired transformation. GEECCO will pursue the following objectives in order to enhance systemic institutional change towards gender equality in the STEM-field: (i) Setting up change framework and a tailor-made GEP for each participating RPO; (ii) Implementing gender criteria in the activities of RFOs; (iii) Setting up a self-reflective learning environment in and between all RPOs und RFOs to participate from existing experiences and match them with their specific needs and circumstances. Facilitators will build up appropriate communication structures and processes within the RPOs and RFOs. They will enable the RPOs and RFOs to help themselves in the longer term dealing with internal resistances against gender equality. (iv) Evaluate GEP implementation within the participating RPOs and RFOs with a quantitative evaluation using monitoring indicators and a qualitative monitoring to enhance and fine-tune implemented actions over the course of the project. GEECCO will develop the “GEECCO Experience: Dos and Don’ts while Degenderizing the STEM Field”, a guideline for RPOs and RFOs in the STEM field how to promote gender equality in the STEM field and intends to participate in standardization processes at EU level to measure “gender balance performance” of RPOs and RFOs.
project/european
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Social and economic transformations", "Democracy and Governance", "Culture, cultural heritage and creativity" ] ]
220718
Stratified turbulence and mixing processes
We propose to study turbulence and mixing in stably stratified fluid. Mixing is central to a wide range of questions from the heat uptake in the global ocean, the transport and dilution of pollutants in the atmosphere, the efficient cooling of buildings, to the homogenising of products in the food industry. However, the mechanisms that are responsible and their physical and dynamical aspects are largely unknown, and it is not possible to predict mixing rates from a knowledge of the overall flow and density fields. We have invented a new laboratory experiment that produces a maintained stratified shear flow in parameter ranges directly applicable to the situations described above. The experiment, consisting of a two-layer counterflow in a stratified inclined duct, is easy to use and highly flexible. A rich variety of flows from transitional, to spatial and temporal intermittent flow, to fully turbulent flow are obtained, and can be maintained for long times to explore the life-cycles of the turbulence. We have also developed a unique capability to make near-instantaneous, highly spatially resolved, measurements of all three components of velocity and the density field over a volume. This capability allows, for the first time in a laboratory experiment, measurements of all the quantities of interest over a three-dimensional region. In addition we have a computational code with which we will carry out direct numerical simulations (DNS) of the experiments over a limited region of parameter space. We will use data from the experiments as initial conditions for the DNS, and compare the time evolution of the flow in the computations and the experiments. We will then use the experiments to extrapolate the results to the full scale. This study, using the new experiment and diagnostics and state-of-the-art computations, will provide new insights into the dynamics of stratified turbulence and set the standard for future studies of this problem.
project/european
[ [ "Climate, Energy and Mobility", "Digital, Industry and Space" ] ]
[ [ "Climate science and solutions", "Buildings and industrial facilities in energy transition", "Energy systems and grids" ] ]
221322
Bright-Night researchers’ impact in everyday life
The BRIGHT-NIGHT project aims to improve the visibility and image of researchers among the common people in the Tuscany Region, simultaneously with all the initiatives of the European Researchers' Night (ERN). The name BRIGHT, coined in 2013 and used in the subsequent ERN editions, was kept for the 2020 project because it is now established and recognizable throughout the entire academic community, the media and the population of Tuscany at large. Nonetheless, after 6 years it was deemed advisable to refresh the brand for the new edition adding “NIGHT” for playing on the concept that it will be a night in which the future will seem brighter thanks to the outcome of research and the passion of researchers. The project is scheduled for the year 2020 and will last from Friday to Saturday on the date scheduled for ERN. In these two days there will be hundreds of fun and exciting activities that will involve the main Tuscan cities, that will follow on from a set of preparatory events. The 20th anniversary of the European Charter of Rights and the 2030 Agenda of the United Nations constitute the framework within which the topics will be developed and declined in the directions of social and environmental sustainability. BRIGHT-NIGHT will involve the population, and in particular young students from primary and secondary schools, through the project of some scientific citizens and through pre-events spread throughout the period. This long-term involvement aims to create a strong link between researchers (who will also participate in a course on scientific communication), young students and the general population in order to make researchers more ""familiar"" and better understand to people how researchers work and live and why to trust them. The locations of the activities are: university premises, museums, botanical gardens, institutional buildings and especially streets and squares in the city centres.
project/european
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Social and economic transformations", "Democracy and Governance", "Culture, cultural heritage and creativity" ] ]
3726758
Do private schools increase academic achievement? Evidence from France
CONTACT Léonard Moulin [email protected] Institut national d'études démographiques (INED), F-93300 Aubervilliers, FranceSupplemental data for this article can be accessed at http://dx.doi.org/10.1080/09645292.2022.2061428
publication
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Social and economic transformations" ] ]
W4223899732
Understanding the role of microbiome interactions in the freezing stress tolerance of plants
Current methods used by growers to prevent or reduce freezing damage include mainly physical approaches, which have several limitations in terms of cost, efficacy and environmental impact. The use of natural plant beneficial bacteria is a promising approach against freezing damage. With the aim of developing new microbial-based products for freezing protection of apple, the goal of this project is to taxonomically and functionally characterise the bacterial communities associated with the anthosphere of a wild cold-adapted rosaceous plant (Dryas octopetala) and to assess their freezing protection abilities on apple. To achieve these goals, we will use the combination of high-throughput sequencing and rapid throughput screening of bacterial isolates with interdisciplinary approaches of molecular biology, bioinformatics, microbiology and plant physiology. In particular, bacterial taxa associated with D. octopetala flowers under freezing stress tolerance will be identified and targeted isolation methods will be used to recover psychrophilic bacteria. Screening of bacterial isolates will be carried out to examine their ice-active traits (ice recrystallization inhibition and ice shaping) and environmental stress tolerance (drought, starving and UV). Efficacy tests of the isolates for their freezing protection abilities on apple will be performed, followed by feasibility checking of industrial production of the best candidates. The scientific outcomes of this project will contribute in the development of a microbial product for freezing protection of fruit crops that will be further developed for the EU market, which agrees with the promotion of sustainable biological methods. FreezingBioprotector will be fundamental to my professional career development by broadening my expertise in microbial ecology and crop protection, as well as transferable skills on teamwork, leadership, analytical thinking and project management that will be essential for my future research career.
project/european
[ [ "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Biodiversity and natural resources", "Circular systems", "Bio-based innovation systems in the bioeconomy", "Agriculture, forestry and rural areas" ] ]
651092
METHOD FOR OPERATING A FIRST AND AT LEAST ONE SECOND FIELD DEVICE
The invention relates to a method for operating a first and at least one second field device (F1, F2), wherein the first field device (F1) and the at least one second field device (F2) are in a first communication connection (N1) for process controlling and/or process monitoring, preferably as a participant of a first network, e.g. via the first network, wherein a second communication connection (N2) is provided, in particular established, between the first field device (F1) and the at least one second field device (F2), via which second communication connection (N2) a communication can be carried out that is independent of the process controlling and/or process monitoring.
patent
[ [ "Digital, Industry and Space" ] ]
[ [ "Manufacturing technologies" ] ]
EP 2015076768 W
Le parole per dire che esistiamo
La présente contribution vise à interroger le rôle du port dans l’invention linguistique et littéraire de Sergio Atzeni, dans une perspective géocritique et postcoloniale. L’appartenance portuaire de l’écrivain, l’hybridisme culturel propre à sa Cagliari semblent en effet constituer, sur le plan de l’écriture, le présupposé spatial nécessaire pour l’emploi d’un plurilinguisme méditerranéen, à entendre à la fois comme instrument de refondation maritime de l’histoire de la Sardaigne, ainsi que moyen narratif à travers lequel (re)définir les traits liquides d’une identité. Au cours de la première section, intitulée “Portualità, plurilinguismo e derive postcoloniali: narrazione mimetica di un’identità plurale”, nous examinerons le rapport entre espace portuaire et oralité narrative, avec une attention particulière pour les architectures plurielles des banlieues cagliaritaines dans Bellas Mariposas. Le deuxième paragraphe, “Oralità, plurilinguismo e derive fiabesche: prospettive narrative di una nuova storicità”, se concentrera plutôt sur le pouvoir fondateur de cette langue orale dans une perspective ethnographique et identitaire. Un espace important sera accordé, dans ce sens, aux travaux de traduction et, tout particulièrement, aux commixtions imaginatives des Fiabe Sarde.
publication
[ [ "Culture, Creativity and Inclusive Society" ] ]
[ [ "Culture, cultural heritage and creativity" ] ]
W4382618512
METHOD FOR ANALYZING THE OPERATION OF A GAS TURBINE
The invention relates to a method for analyzing the operation of a gas turbine (1), wherein one or more neural networks based on the normal operation of the gas turbine are learned. At least one dynamic pressure signal (V5) is read by at least one pressure sensor (8) in or on the compressor (2) of the gas turbine (1), and one or more operating parameters (V1, V2, V3, V4) of the gas turbine (1) are read by one or more further sensors (4, 5, 6, 7) in normal operation of the gas turbine (1), and/or a dynamic pressure signal (V5) and one or more operating parameters (V1, V2, V3, V4) of the gas turbine (1) are read that were measured during normal operation of the gas turbine (1). The dynamic pressure signal (V5) is subjected to a frequency analysis, whereby one or more parameters of the frequency spectrum of the pressure signal (V5) are determined. Based on the measured operating parameters (V1, V2, V3, V4) and the parameters of the frequency spectrum of the pressure signal (V5), one or more neural networks are learned, comprising the measured operating parameters (V1, V2, V3, V4) and the parameters of the frequency spectrum of the pressure signal (V5) as input parameters, and having as an output parameter at least one diagnostic characteristic value representing a probability dimension for the presence of normal operation of the gas turbine (1) as a function of the input parameters.
patent
[ [ "Digital, Industry and Space" ] ]
[ [ "Artificial intelligence and robotics", "Emerging enabling technologies", "Advanced computing and big data", "Manufacturing technologies" ] ]
EP 2008062538 W
Synthesis and Characterization of Cellulose Acetate from TCF Oil Palm Empty Fruit Bunch Pulp
Cellulose acetate (CA) was successfully synthesized by the acetylation of TCF cellulose pulp from oil palm empty fruit bunches (OPEFB) at room temperature, using acetic anhydride as the acetylating agent and acetic acid as the solvent in the presence of sulfuric acid/sodium bisulfate as catalysts. Degree of substitution (DS) was controlled by the variables of acetylation time and acetic anhydride to cellulose ratio, under the heterogeneous state. The product (CA) obtained was characterized through Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The results indicate that the CA obtained has characteristics similar to commercial CA, and DS is significantly dependent on acetylation time and the acetic anhydride-to-cellulose ratio.
publication
[ [ "Digital, Industry and Space", "Food, Bioeconomy, Natural Resources, Agriculture and Environment" ] ]
[ [ "Manufacturing technologies", "Circular systems", "Advanced Materials" ] ]
W1974770992
DERIVATIVES COMPRISING AN APELIN ANALOGUE AND USES THEREOF
The present invention relates to derivatives comprising an apelin analogue; wherein the apelin analogue comprises two amino acids having a sulphur atom in the side chain, wherein said two amino acids are covalently linked via a methylene bridge. The invention also relates to the pharmaceutical use of the derivatives, preferably in the treatment of all forms of cardiovascular disease.
patent
[ [ "Health", "Digital, Industry and Space" ] ]
[ [ "Non-communicable and rare diseases", "Tools, technologies and digital solutions for health and care, including personalised medicine" ] ]
EP 2019064202 W