pietrolesci/pubmed-200k-rct · Datasets at Hugging Face

labels class label 5 classes	text stringlengths 3 1.81k	uid int64 0 2.21M
4RESULTS	With ST , there was significant improvement of only respiratory rate ( p < 0.05 ) .	2,211,500
4RESULTS	However , with NPPV , PaO2 ( p < 0.001 ) , PaCO2 ( p < 0.001 ) , pH ( p < 0.001 ) , and respiratory rate ( p < 0.001 ) improved significantly compared with baseline .	2,211,501
4RESULTS	Six hours after randomization , pH ( p < 0.01 ) and respiratory rate ( p < 0.01 ) in NPPV patients were significantly better than with ST. Hospital stay for NPPV vs ST patients was , respectively , 11.7 + / -3.5 and 14.6 + / -4.7 days ( p < 0.05 ) .	2,211,502
4RESULTS	One patient in the NPPV group required invasive mechanical ventilation .	2,211,503
4RESULTS	The conditions of six patients in the ST group deteriorated and they were switched to NPPV ; this was successful in four patients , two failures were invasively ventilated .	2,211,504
1CONCLUSIONS	This study suggests that early application of NPPV in HARF patients facilitates improvement , decreases need for invasive mechanical ventilation , and decreases the duration of hospitalization .	2,211,505
3OBJECTIVE	Patients with Crohn 's disease ( CD ) often require surgery over their clinical course .	2,211,506
3OBJECTIVE	However , endoscopic and clinical recurrence of disease appear respectively in up to 80 % and 30 % of patients after one year .	2,211,507
3OBJECTIVE	Thus , a prophylactic treatment is needed to reduce the possibility of recurrence .	2,211,508
3OBJECTIVE	Both azathioprine and infliximab have been demonstrated to be effective , but head to head studies have not been performed so far .	2,211,509
3OBJECTIVE	Aim of this open-label prospective study was to analyse endoscopic , histological and clinical recurrence after one year of treatment with azathioprine or infliximab as postoperative therapies in CD patients with `` high risk '' of recurrence .	2,211,510
2METHODS	Consecutive CD patients who underwent curative ileocolonic resection were randomized ( 1:1 ) to receive infliximab ( standard induction and maintenance schedule ) or azathioprine ( 2.5 mg/kg/day ) for 1 year .	2,211,511
2METHODS	Co-primary endpoints were endoscopic , histological and clinical recurrence after 12 months of therapy .	2,211,512
4RESULTS	Twenty-two consecutive CD patients ( 15 male ; median age 32 years , IQR 22-38 ) were enrolled after curative ileocolonic resection .	2,211,513
4RESULTS	Eleven patients were treated with infliximab and 11 received azathioprine .	2,211,514
4RESULTS	Among patients treated with azathioprine , 4/10 ( 40 % ) had endoscopic recurrence compared to 1/11 ( 9 % ) in the infliximab group ( p = 0.14 ) .	2,211,515
4RESULTS	Eight out of 10 ( 80 % ) among those who received azathioprine had severe histological activity , whereas 2/11 ( 18 % ) in the infliximab group presented histological recurrence ( p = 0.008 ) .	2,211,516
4RESULTS	No significant clinical differences were found between the two groups .	2,211,517
1CONCLUSIONS	Infliximab was more effective than azathioprine in reducing histological , but not endoscopic and clinical recurrence after curative ileocolonic resection in `` high risk '' CD patients .	2,211,518
0BACKGROUND	Immediate loading of osseointegrating implants shortens the treatment time and makes it possible to give the patient an esthetic appearance during the whole treatment period .	2,211,519
0BACKGROUND	A previous retrospective clinical study showed a success rate of 94.2 % after 1 year of immediate loading of fixed partial constructions in the maxilla supported by machined-surface implants .	2,211,520
0BACKGROUND	The recently introduced Brnemark System TiUnite ( Nobel Biocare AB , Gothenburg , Sweden ) surface has been shown to better maintain primary implant stability and to help achieve secondary stability earlier compared with the machined surface .	2,211,521
3OBJECTIVE	The aim of the present study was to compare TiUnite and machined-surfaced Brnemark System implants when applying immediate loading of partial fixed bridges in the posterior mandible .	2,211,522
2METHODS	Forty-four patients were randomized for test and control therapy .	2,211,523
2METHODS	In the test group , 22 patients received 66 Brnemark System TiUnite surface implants supporting 24 fixed partial bridges , all of which were connected on the day of implant insertion .	2,211,524
2METHODS	In the control group , 22 patients received 55 Brnemark System machined-surface implants supporting 22 fixed partial bridges , which also were connected on the day of implant insertion .	2,211,525
2METHODS	All constructions were two - to four-unit bridges .	2,211,526
2METHODS	Bone quality and quantity were assessed .	2,211,527
2METHODS	Radiographic examinations were performed on the day of surgery/loading and at the 1-year follow-up visit .	2,211,528
4RESULTS	Three TiUnite and eight machined-surface implants failed during the first 7 weeks of loading .	2,211,529
4RESULTS	This resulted in a cumulative success rate of 95.5 % for TiUnite surface implants after 1 year of prosthetic load in the posterior mandible .	2,211,530
4RESULTS	The corresponding cumulative success rate for machined-surface implants was 85.5 % .	2,211,531
4RESULTS	When using the machined-surface implants , the number of failed implants was significantly higher in smokers and in bone quality 4 sites .	2,211,532
4RESULTS	Such findings were not seen with the use of TiUnite implants , despite the fact that there were more smokers and more implants placed in bone quality 4 in this group .	2,211,533
4RESULTS	The marginal bone resorption after 1 year of loading was on average 0.9 mm ( SD 0.7 mm ) with the TiUnite implants and 1.0 mm ( SD 0.9 mm ) with the machined implants .	2,211,534
1CONCLUSIONS	The present study demonstrated a 10 % higher success rate following immediate loading of partial fixed bridges in the posterior mandible supported by TiUnite surface implants compared with success with machined implants .	2,211,535
1CONCLUSIONS	When using the machined implants , the number of failed implants was significantly higher in smokers and in bone quality 4 sites .	2,211,536
1CONCLUSIONS	Such findings were not seen following the use of TiUnite implants .	2,211,537
3OBJECTIVE	To compare intracameral levels and clinical efficacy of lidocaine 2 % gel with lidocaine 4 % unpreserved drops .	2,211,538
2METHODS	Double-blind , randomized , one-surgeon , controlled trial .	2,211,539
2METHODS	One hundred seven consecutive cataract cases eligible for topical anesthesia .	2,211,540
2METHODS	Patients were randomly assigned to receive 20 mg of lidocaine either as lidocaine 2 % gel ( 1 ml ) or as lidocaine 4 % unpreserved eyedrops ( 0.5 ml ) before clear corneal phacoemulsification .	2,211,541
2METHODS	Aqueous samples were taken to measure lidocaine intraocular levels .	2,211,542
2METHODS	Intraoperative pain was quantified a few minutes after surgery using a 0 to 10 visual analog scale .	2,211,543
2METHODS	Patients were asked to grade the degree to which they were bothered by tissue manipulation .	2,211,544
2METHODS	The surgeon graded patients ' cooperation .	2,211,545
2METHODS	The anesthesiologist recorded any increase in pulse or blood pressure and the need for supplemental topical anesthesia or intravenous sedation .	2,211,546
2METHODS	Duration of surgery and intraoperative complications were also recorded .	2,211,547
4RESULTS	In the gel group intracameral lidocaine levels were significantly higher ( P < 0.001 ) and patient-reported intraoperative pain scores were significantly lower ( P = 0.026 ) .	2,211,548
4RESULTS	Patients in the gel group were bothered by tissue manipulation to a lesser extent ( P = 0.028 ) , and their cooperation was better ( P = 0.002 ) .	2,211,549
4RESULTS	Increases in blood pressure were more frequent in the eyedrops group .	2,211,550
4RESULTS	Supplemental anesthesia was required in two cases ( 3.70 % ) in the gel group versus eight cases in the eyedrops group ( 15.09 % ) .	2,211,551
4RESULTS	No correlation between intracameral lidocaine levels and intraoperative pain scores was found ( r = -0.026 , P = 0.789 ) .	2,211,552
1CONCLUSIONS	If administered by means of gel , the same amount of lidocaine gives significantly higher intracameral levels of lidocaine , better analgesia , better patient cooperation , and less need for intraoperative supplemental anesthesia .	2,211,553
1CONCLUSIONS	Lower pain scores do not correlate with intracameral lidocaine levels .	2,211,554
0BACKGROUND	Psychosocial stress profoundly impacts long-term cardiovascular health through adverse effects on sympathetic nervous system activity , endothelial dysfunction , and atherosclerotic development .	2,211,555
0BACKGROUND	Recreational Music Making ( RMM ) is a unique stress amelioration strategy encompassing group music-based activities that has great therapeutic potential for treating patients with stress-related cardiovascular disease .	2,211,556
2METHODS	Participants ( n = 34 ) with a history of ischemic heart disease were subjected to an acute time-limited stressor , then randomized to RMM or quiet reading for one hour .	2,211,557
2METHODS	Peripheral blood gene expression using GeneChip Human Genome U133A 2.0 arrays was assessed at baseline , following stress , and after the relaxation session .	2,211,558
4RESULTS	Full gene set enrichment analysis identified 16 molecular pathways differentially regulated ( P < 0.005 ) during stress that function in immune response , cell mobility , and transcription .	2,211,559
4RESULTS	During relaxation , two pathways showed a significant change in expression in the control group , while 12 pathways governing immune function and gene expression were modulated among RMM participants .	2,211,560
4RESULTS	Only 13 % ( 2/16 ) of pathways showed differential expression during stress and relaxation .	2,211,561
1CONCLUSIONS	Human stress and relaxation responses may be controlled by different molecular pathways .	2,211,562
1CONCLUSIONS	Relaxation through active engagement in Recreational Music Making may be more effective than quiet reading at altering gene expression and thus more clinically useful for stress amelioration .	2,211,563
3OBJECTIVE	The goal of this study was to determine whether azimilide , as compared with placebo , will reduce the number of emergency department ( ED ) visits and hospitalizations caused by arrhythmias or cardiac events in patients with an implantable cardioverter-defibrillator ( ICD ) .	2,211,564
0BACKGROUND	Patients with an ICD may require ED visits and hospitalizations because of arrhythmias , which trigger ICD therapies .	2,211,565
0BACKGROUND	The effect of adjunctive antiarrhythmic therapy on these outcomes is not known .	2,211,566
2METHODS	A total of 633 patients with an ICD were randomized in the SHIELD ( SHock Inhibition Evaluation with AzimiLiDe ) trial , a blinded , placebo-controlled randomized trial of the investigational class III antiarrhythmic azimilide ( 75 and 125 mg/day ) , and , prospectively , cardiac and arrhythmic ED visits and hospitalization data were collected over 1 year .	2,211,567
4RESULTS	All patients had symptomatic sustained ventricular tachycardia ( 72 % ) or ventricular fibrillation ( 28 % ) before study entry .	2,211,568
4RESULTS	Overall , 44 % ( n = 276 ) experienced at least 1 cardiac ED visit or hospitalization .	2,211,569
4RESULTS	Among 214 patients assigned to placebo , 38.3 % had at least 1 arrhythmic-related ED visit or hospitalization compared with 21.8 % of 220 patients assigned to 75-mg azimilide ( p < 0.001 ) and 27.6 % of 199 patients assigned to 125 mg azimilide ( p < 0.05 ) .	2,211,570
4RESULTS	Symptomatic ventricular tachycardia treated by antitachycardia pacing , shocks , and shocks plus symptomatic arrhythmias were significant predictors of cardiac-related ED visits or hospitalizations ( relative risk : 2.0 , 3.0 , and 3.1 , respectively ) .	2,211,571
4RESULTS	In a stepwise logistic regression model , the presence of congestive heart failure ( New York Heart Association functional class II/III ) was the only additional independent predictor of cardiac ED visits or hospitalizations .	2,211,572
1CONCLUSIONS	Azimilide significantly reduces the number of ED visits and hospitalizations in patients with an ICD at high risk of arrhythmias .	2,211,573
3OBJECTIVE	Our aim was to test the hypothesis that acetylsalicylate ( aspirin ) treatment reduces the incidence or severity of pregnancy-associated hypertension .	2,211,574
2METHODS	Patients were nulliparous , healthy , and with a singleton gestation at between 20 and 22 weeks ' gestation .	2,211,575
2METHODS	A sample size of 600 patients was calculated on the basis of p < or = 0.05 and 90 % power of observation .	2,211,576
2METHODS	A 2-week placebo-controlled `` run-in '' was used to select compliant patients .	2,211,577
2METHODS	Randomization occurred at 24 weeks , with 60 mg of aspirin or placebo treatment from randomization to delivery .	2,211,578
4RESULTS	Follow-up was maintained on 99 % of the patients .	2,211,579
4RESULTS	The randomized patients had a 94 % pill compliance index .	2,211,580
4RESULTS	At randomization , serum thromboxane medians were similar in both groups .	2,211,581
4RESULTS	Thromboxane B2 levels in the aspirin group decreased significantly from baseline at 29 to 31 weeks , 34 to 36 weeks , and at delivery as compared with an overall increase in the placebo group .	2,211,582
4RESULTS	Preeclampsia developed in five of 302 women ( 1.7 % ) who received aspirin versus 17 of 302 ( 5.6 % ) who received the placebo ( p = 0.009 ) .	2,211,583
4RESULTS	Preeclampsia was severe in one aspirin and in six placebo recipients ( p = 0.06 ) .	2,211,584
1CONCLUSIONS	Daily ingestion of 60 mg of aspirin beginning at 24 weeks ' gestation significantly reduced the occurrence of preeclampsia .	2,211,585
3OBJECTIVE	To assess the efficacy and safety of interferon-alpha ( IFN-alpha ) in children with Hepatitis B e antigen-positive chronic hepatitis B virus infection .	2,211,586
2METHODS	PubMed and Chinese Biomedical Database were searched from the beginning of operation of the databases to April 2006 , and the references of eligible studies were manually screened .	2,211,587
2METHODS	Randomized controlled trials ( RCTs ) published in the English and Chinese literature comparing interferon-alpha with non-antiviral interventions ( placebo or no treatment ) in children with hepatitis B e antigen-positive chronic hepatitis B virus infection were eligible for inclusion .	2,211,588
2METHODS	Studies were included if patients were treated for at least 3 months and followed-up for at least 6 months after cessation of therapy .	2,211,589
2METHODS	Two investigators independently assessed the quality and extracted the data .	2,211,590
2METHODS	The methodological quality of trails was assessed by the Jadad-scale plus allocation concealment .	2,211,591
2METHODS	Heterogeneity was examined by Chi-square test .	2,211,592
2METHODS	Fixed effects model or random effects model were used to pool the data .	2,211,593
2METHODS	Sensitivity analyses were used for the treatment course .	2,211,594
4RESULTS	Ten randomized controlled studies with a total of 542 children chronic HBV carriers who were positive for hepatitis B surface antigen ( HBsAg ) and hepatitis B e antigen ( HBeAg ) were identified .	2,211,595
4RESULTS	It was found by the meta-analysis that , compared with the control , at the end of the follow-up period , IFN-alpha could still significantly clear HBeAg [ 31.1 % vs. 12.4 % , odds ratio ( OR ) : 3.17 , 95 % CI ( 2.00 , 5.02 ) , P < 0.000 01 ] , clear HBV-DNA [ 33.9 % vs. 16.2 % , OR : 2.59 , 95 % CI ( 1.70 , 3.96 ) , P < 0.0001 ] , clear HBsAg [ 5.5 % vs. 1.2 % , OR : 3.44 , 95 % CI ( 1.20 , 9.89 ) , P = 0.02 ] , normalize ALT [ 43.0 % vs. 27.7 % , OR : 1.99 , 95 % CI ( 1.16 , 3.42 ) , P = 0.01 ] , and achieve HBeAg seroconversion [ 30.4 % vs. 12.8 % , OR : 2.90 , 95 % CI ( 1.56 , 5.39 ) , P = 0.0008 ] , but was not effective in HBsAg seroconversion [ 1.9 % vs. 0 , 95 % CI ( 0.42 , 18.13 ) , P = 0.29 ] .	2,211,596
1CONCLUSIONS	Interferon-alpha might be efficacious in clearance of HBeAg , HBV-DNA and HBsAg , normalization of ALT , and achievement of HBeAg seroconversion in children with chronic hepatitis B. Little evidence is available on HBsAg seroconversion .	2,211,597
1CONCLUSIONS	Further RCTs of high-quality and sufficient number of cases are needed for confirmation of the clinical efficacy of IFN-alpha in chronic hepatitis B in children .	2,211,598
0BACKGROUND	Submassive pulmonary embolism ( PE ) has a low mortality rate but can degrade functional capacity .	2,211,599

4RESULTS

With ST , there was significant improvement of only respiratory rate ( p < 0.05 ) .

2,211,500

4RESULTS

However , with NPPV , PaO2 ( p < 0.001 ) , PaCO2 ( p < 0.001 ) , pH ( p < 0.001 ) , and respiratory rate ( p < 0.001 ) improved significantly compared with baseline .

2,211,501

4RESULTS

Six hours after randomization , pH ( p < 0.01 ) and respiratory rate ( p < 0.01 ) in NPPV patients were significantly better than with ST. Hospital stay for NPPV vs ST patients was , respectively , 11.7 + / -3.5 and 14.6 + / -4.7 days ( p < 0.05 ) .

2,211,502

4RESULTS

One patient in the NPPV group required invasive mechanical ventilation .

2,211,503

4RESULTS

The conditions of six patients in the ST group deteriorated and they were switched to NPPV ; this was successful in four patients , two failures were invasively ventilated .

2,211,504

1CONCLUSIONS

This study suggests that early application of NPPV in HARF patients facilitates improvement , decreases need for invasive mechanical ventilation , and decreases the duration of hospitalization .

2,211,505

3OBJECTIVE

Patients with Crohn 's disease ( CD ) often require surgery over their clinical course .

2,211,506

3OBJECTIVE

However , endoscopic and clinical recurrence of disease appear respectively in up to 80 % and 30 % of patients after one year .

2,211,507

3OBJECTIVE

Thus , a prophylactic treatment is needed to reduce the possibility of recurrence .

2,211,508

3OBJECTIVE

Both azathioprine and infliximab have been demonstrated to be effective , but head to head studies have not been performed so far .

2,211,509

3OBJECTIVE

Aim of this open-label prospective study was to analyse endoscopic , histological and clinical recurrence after one year of treatment with azathioprine or infliximab as postoperative therapies in CD patients with `` high risk '' of recurrence .

2,211,510

2METHODS

Consecutive CD patients who underwent curative ileocolonic resection were randomized ( 1:1 ) to receive infliximab ( standard induction and maintenance schedule ) or azathioprine ( 2.5 mg/kg/day ) for 1 year .

2,211,511

2METHODS

Co-primary endpoints were endoscopic , histological and clinical recurrence after 12 months of therapy .

2,211,512

4RESULTS

Twenty-two consecutive CD patients ( 15 male ; median age 32 years , IQR 22-38 ) were enrolled after curative ileocolonic resection .

2,211,513

4RESULTS

Eleven patients were treated with infliximab and 11 received azathioprine .

2,211,514

4RESULTS

Among patients treated with azathioprine , 4/10 ( 40 % ) had endoscopic recurrence compared to 1/11 ( 9 % ) in the infliximab group ( p = 0.14 ) .

2,211,515

4RESULTS

Eight out of 10 ( 80 % ) among those who received azathioprine had severe histological activity , whereas 2/11 ( 18 % ) in the infliximab group presented histological recurrence ( p = 0.008 ) .

2,211,516

4RESULTS

No significant clinical differences were found between the two groups .

2,211,517

1CONCLUSIONS

Infliximab was more effective than azathioprine in reducing histological , but not endoscopic and clinical recurrence after curative ileocolonic resection in `` high risk '' CD patients .

2,211,518

0BACKGROUND

Immediate loading of osseointegrating implants shortens the treatment time and makes it possible to give the patient an esthetic appearance during the whole treatment period .

2,211,519

0BACKGROUND

A previous retrospective clinical study showed a success rate of 94.2 % after 1 year of immediate loading of fixed partial constructions in the maxilla supported by machined-surface implants .

2,211,520

0BACKGROUND

The recently introduced Brnemark System TiUnite ( Nobel Biocare AB , Gothenburg , Sweden ) surface has been shown to better maintain primary implant stability and to help achieve secondary stability earlier compared with the machined surface .

2,211,521

3OBJECTIVE

The aim of the present study was to compare TiUnite and machined-surfaced Brnemark System implants when applying immediate loading of partial fixed bridges in the posterior mandible .

2,211,522

2METHODS

Forty-four patients were randomized for test and control therapy .

2,211,523

2METHODS

In the test group , 22 patients received 66 Brnemark System TiUnite surface implants supporting 24 fixed partial bridges , all of which were connected on the day of implant insertion .

2,211,524

2METHODS

In the control group , 22 patients received 55 Brnemark System machined-surface implants supporting 22 fixed partial bridges , which also were connected on the day of implant insertion .

2,211,525

2METHODS

All constructions were two - to four-unit bridges .

2,211,526

2METHODS

Bone quality and quantity were assessed .

2,211,527

2METHODS

Radiographic examinations were performed on the day of surgery/loading and at the 1-year follow-up visit .

2,211,528

4RESULTS

Three TiUnite and eight machined-surface implants failed during the first 7 weeks of loading .

2,211,529

4RESULTS

This resulted in a cumulative success rate of 95.5 % for TiUnite surface implants after 1 year of prosthetic load in the posterior mandible .

2,211,530

4RESULTS

The corresponding cumulative success rate for machined-surface implants was 85.5 % .

2,211,531

4RESULTS

When using the machined-surface implants , the number of failed implants was significantly higher in smokers and in bone quality 4 sites .

2,211,532

4RESULTS

Such findings were not seen with the use of TiUnite implants , despite the fact that there were more smokers and more implants placed in bone quality 4 in this group .

2,211,533

4RESULTS

The marginal bone resorption after 1 year of loading was on average 0.9 mm ( SD 0.7 mm ) with the TiUnite implants and 1.0 mm ( SD 0.9 mm ) with the machined implants .

2,211,534

1CONCLUSIONS

The present study demonstrated a 10 % higher success rate following immediate loading of partial fixed bridges in the posterior mandible supported by TiUnite surface implants compared with success with machined implants .

2,211,535

1CONCLUSIONS

When using the machined implants , the number of failed implants was significantly higher in smokers and in bone quality 4 sites .

2,211,536

1CONCLUSIONS

Such findings were not seen following the use of TiUnite implants .

2,211,537

3OBJECTIVE

To compare intracameral levels and clinical efficacy of lidocaine 2 % gel with lidocaine 4 % unpreserved drops .

2,211,538

2METHODS

Double-blind , randomized , one-surgeon , controlled trial .

2,211,539

2METHODS

One hundred seven consecutive cataract cases eligible for topical anesthesia .

2,211,540

2METHODS

Patients were randomly assigned to receive 20 mg of lidocaine either as lidocaine 2 % gel ( 1 ml ) or as lidocaine 4 % unpreserved eyedrops ( 0.5 ml ) before clear corneal phacoemulsification .

2,211,541

2METHODS

Aqueous samples were taken to measure lidocaine intraocular levels .

2,211,542

2METHODS

Intraoperative pain was quantified a few minutes after surgery using a 0 to 10 visual analog scale .

2,211,543

2METHODS

Patients were asked to grade the degree to which they were bothered by tissue manipulation .

2,211,544

2METHODS

The surgeon graded patients ' cooperation .

2,211,545

2METHODS

The anesthesiologist recorded any increase in pulse or blood pressure and the need for supplemental topical anesthesia or intravenous sedation .

2,211,546

2METHODS

Duration of surgery and intraoperative complications were also recorded .

2,211,547

4RESULTS

In the gel group intracameral lidocaine levels were significantly higher ( P < 0.001 ) and patient-reported intraoperative pain scores were significantly lower ( P = 0.026 ) .

2,211,548

4RESULTS

Patients in the gel group were bothered by tissue manipulation to a lesser extent ( P = 0.028 ) , and their cooperation was better ( P = 0.002 ) .

2,211,549

4RESULTS

Increases in blood pressure were more frequent in the eyedrops group .

2,211,550

4RESULTS

Supplemental anesthesia was required in two cases ( 3.70 % ) in the gel group versus eight cases in the eyedrops group ( 15.09 % ) .

2,211,551

4RESULTS

No correlation between intracameral lidocaine levels and intraoperative pain scores was found ( r = -0.026 , P = 0.789 ) .

2,211,552

1CONCLUSIONS

If administered by means of gel , the same amount of lidocaine gives significantly higher intracameral levels of lidocaine , better analgesia , better patient cooperation , and less need for intraoperative supplemental anesthesia .

2,211,553

1CONCLUSIONS

Lower pain scores do not correlate with intracameral lidocaine levels .

2,211,554

0BACKGROUND

Psychosocial stress profoundly impacts long-term cardiovascular health through adverse effects on sympathetic nervous system activity , endothelial dysfunction , and atherosclerotic development .

2,211,555

0BACKGROUND

Recreational Music Making ( RMM ) is a unique stress amelioration strategy encompassing group music-based activities that has great therapeutic potential for treating patients with stress-related cardiovascular disease .

2,211,556

2METHODS

Participants ( n = 34 ) with a history of ischemic heart disease were subjected to an acute time-limited stressor , then randomized to RMM or quiet reading for one hour .

2,211,557

2METHODS

Peripheral blood gene expression using GeneChip Human Genome U133A 2.0 arrays was assessed at baseline , following stress , and after the relaxation session .

2,211,558

4RESULTS

Full gene set enrichment analysis identified 16 molecular pathways differentially regulated ( P < 0.005 ) during stress that function in immune response , cell mobility , and transcription .

2,211,559

4RESULTS

During relaxation , two pathways showed a significant change in expression in the control group , while 12 pathways governing immune function and gene expression were modulated among RMM participants .

2,211,560

4RESULTS

Only 13 % ( 2/16 ) of pathways showed differential expression during stress and relaxation .

2,211,561

1CONCLUSIONS

Human stress and relaxation responses may be controlled by different molecular pathways .

2,211,562

1CONCLUSIONS

Relaxation through active engagement in Recreational Music Making may be more effective than quiet reading at altering gene expression and thus more clinically useful for stress amelioration .

2,211,563

3OBJECTIVE

The goal of this study was to determine whether azimilide , as compared with placebo , will reduce the number of emergency department ( ED ) visits and hospitalizations caused by arrhythmias or cardiac events in patients with an implantable cardioverter-defibrillator ( ICD ) .

2,211,564

0BACKGROUND

Patients with an ICD may require ED visits and hospitalizations because of arrhythmias , which trigger ICD therapies .

2,211,565

0BACKGROUND

The effect of adjunctive antiarrhythmic therapy on these outcomes is not known .

2,211,566

2METHODS

A total of 633 patients with an ICD were randomized in the SHIELD ( SHock Inhibition Evaluation with AzimiLiDe ) trial , a blinded , placebo-controlled randomized trial of the investigational class III antiarrhythmic azimilide ( 75 and 125 mg/day ) , and , prospectively , cardiac and arrhythmic ED visits and hospitalization data were collected over 1 year .

2,211,567

4RESULTS

All patients had symptomatic sustained ventricular tachycardia ( 72 % ) or ventricular fibrillation ( 28 % ) before study entry .

2,211,568

4RESULTS

Overall , 44 % ( n = 276 ) experienced at least 1 cardiac ED visit or hospitalization .

2,211,569

4RESULTS

Among 214 patients assigned to placebo , 38.3 % had at least 1 arrhythmic-related ED visit or hospitalization compared with 21.8 % of 220 patients assigned to 75-mg azimilide ( p < 0.001 ) and 27.6 % of 199 patients assigned to 125 mg azimilide ( p < 0.05 ) .

2,211,570

4RESULTS

Symptomatic ventricular tachycardia treated by antitachycardia pacing , shocks , and shocks plus symptomatic arrhythmias were significant predictors of cardiac-related ED visits or hospitalizations ( relative risk : 2.0 , 3.0 , and 3.1 , respectively ) .

2,211,571

4RESULTS

In a stepwise logistic regression model , the presence of congestive heart failure ( New York Heart Association functional class II/III ) was the only additional independent predictor of cardiac ED visits or hospitalizations .

2,211,572

1CONCLUSIONS

Azimilide significantly reduces the number of ED visits and hospitalizations in patients with an ICD at high risk of arrhythmias .

2,211,573

3OBJECTIVE

Our aim was to test the hypothesis that acetylsalicylate ( aspirin ) treatment reduces the incidence or severity of pregnancy-associated hypertension .

2,211,574

2METHODS

Patients were nulliparous , healthy , and with a singleton gestation at between 20 and 22 weeks ' gestation .

2,211,575

2METHODS

A sample size of 600 patients was calculated on the basis of p < or = 0.05 and 90 % power of observation .

2,211,576

2METHODS

A 2-week placebo-controlled `` run-in '' was used to select compliant patients .

2,211,577

2METHODS

Randomization occurred at 24 weeks , with 60 mg of aspirin or placebo treatment from randomization to delivery .

2,211,578

4RESULTS

Follow-up was maintained on 99 % of the patients .

2,211,579

4RESULTS

The randomized patients had a 94 % pill compliance index .

2,211,580

4RESULTS

At randomization , serum thromboxane medians were similar in both groups .

2,211,581

4RESULTS

Thromboxane B2 levels in the aspirin group decreased significantly from baseline at 29 to 31 weeks , 34 to 36 weeks , and at delivery as compared with an overall increase in the placebo group .

2,211,582

4RESULTS

Preeclampsia developed in five of 302 women ( 1.7 % ) who received aspirin versus 17 of 302 ( 5.6 % ) who received the placebo ( p = 0.009 ) .

2,211,583

4RESULTS

Preeclampsia was severe in one aspirin and in six placebo recipients ( p = 0.06 ) .

2,211,584

1CONCLUSIONS

Daily ingestion of 60 mg of aspirin beginning at 24 weeks ' gestation significantly reduced the occurrence of preeclampsia .

2,211,585

3OBJECTIVE

To assess the efficacy and safety of interferon-alpha ( IFN-alpha ) in children with Hepatitis B e antigen-positive chronic hepatitis B virus infection .

2,211,586

2METHODS

PubMed and Chinese Biomedical Database were searched from the beginning of operation of the databases to April 2006 , and the references of eligible studies were manually screened .

2,211,587

2METHODS

Randomized controlled trials ( RCTs ) published in the English and Chinese literature comparing interferon-alpha with non-antiviral interventions ( placebo or no treatment ) in children with hepatitis B e antigen-positive chronic hepatitis B virus infection were eligible for inclusion .

2,211,588

2METHODS

Studies were included if patients were treated for at least 3 months and followed-up for at least 6 months after cessation of therapy .

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2METHODS

Two investigators independently assessed the quality and extracted the data .

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2METHODS

The methodological quality of trails was assessed by the Jadad-scale plus allocation concealment .

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2METHODS

Heterogeneity was examined by Chi-square test .

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2METHODS

Fixed effects model or random effects model were used to pool the data .

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2METHODS

Sensitivity analyses were used for the treatment course .

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4RESULTS

Ten randomized controlled studies with a total of 542 children chronic HBV carriers who were positive for hepatitis B surface antigen ( HBsAg ) and hepatitis B e antigen ( HBeAg ) were identified .

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4RESULTS

It was found by the meta-analysis that , compared with the control , at the end of the follow-up period , IFN-alpha could still significantly clear HBeAg [ 31.1 % vs. 12.4 % , odds ratio ( OR ) : 3.17 , 95 % CI ( 2.00 , 5.02 ) , P < 0.000 01 ] , clear HBV-DNA [ 33.9 % vs. 16.2 % , OR : 2.59 , 95 % CI ( 1.70 , 3.96 ) , P < 0.0001 ] , clear HBsAg [ 5.5 % vs. 1.2 % , OR : 3.44 , 95 % CI ( 1.20 , 9.89 ) , P = 0.02 ] , normalize ALT [ 43.0 % vs. 27.7 % , OR : 1.99 , 95 % CI ( 1.16 , 3.42 ) , P = 0.01 ] , and achieve HBeAg seroconversion [ 30.4 % vs. 12.8 % , OR : 2.90 , 95 % CI ( 1.56 , 5.39 ) , P = 0.0008 ] , but was not effective in HBsAg seroconversion [ 1.9 % vs. 0 , 95 % CI ( 0.42 , 18.13 ) , P = 0.29 ] .

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1CONCLUSIONS

Interferon-alpha might be efficacious in clearance of HBeAg , HBV-DNA and HBsAg , normalization of ALT , and achievement of HBeAg seroconversion in children with chronic hepatitis B. Little evidence is available on HBsAg seroconversion .

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1CONCLUSIONS

Further RCTs of high-quality and sufficient number of cases are needed for confirmation of the clinical efficacy of IFN-alpha in chronic hepatitis B in children .

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0BACKGROUND

Submassive pulmonary embolism ( PE ) has a low mortality rate but can degrade functional capacity .

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