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license: mit |
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configs: |
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- config_name: dataset |
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data_files: "dataset.csv" |
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--- |
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### Description |
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This dataset contains signle site mutation of protein DLG4_RAT amino acid sequence and the correspond mutation effect score from a deep mutation scanning experiment. |
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**Protein Format:** AA sequence |
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### Splits |
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traing: 1325 |
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valid: 159 |
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test: 176 |
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### Related paper |
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The dataset is from [Deep generative models of genetic variation capture the effects of mutations](https://www.nature.com/articles/s41592-018-0138-4). |
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### Label |
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Label means fitness score of each mutant amino acid sequence based on a deep mutation scanning experiment. |
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The effect of each mutation is expressed as the log frequency of observing each amino acid x at each position i in the selected versus the unselected population, |
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relative to wild type. Ranging from negative infinity to positive infinity. If the effect larger than 0 represents high fitness, smaller than 0 represents low fitness. |
