id
int64 665
39.8M
| title
stringlengths 5
689
| authors
stringlengths 0
24k
| journal
stringlengths 19
266
| content
stringlengths 1
13.3k
| source_url
stringlengths 36
41
| publication_types
listlengths 2
10
| pubmed_id
stringlengths 3
8
| embedding
listlengths 256
256
|
|---|---|---|---|---|---|---|---|---|
6,816,132 |
Treatment of the "on-off" phenomenon in Parkinsonism with lithium carbonate.
|
Coffey C E CE, Ross D R DR, Ferren E L EL, Sullivan J L JL, Olanow C W CW
|
Annals of neurology . Vol. 12, No. 4, 1982 Oct
|
Six patients with severe parkinsonism complicated by the "on-off" phenomenon were treated with lithium carbonate in addition to regular antiparkinson medications. A randomized double-blind crossover trial of lithium versus placebo was conducted, followed by an open trial of lithium therapy. Five patients had markedly reductions in akinesia (mean, 70%) and improved by one grade in Parkinson staging. This result was more striking in male than in female patients, and in all responders benefit has been maintained during the open phase of lithium treatment (mean follow-up of 36 weeks). In no patient was a reduction in akinesia observed during placebo treatment. Lithium carbonate appears to offer a new and potentially effective approach to treatment of the on-off phenomenon.
|
https://pubmed.ncbi.nlm.nih.gov/6816132/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6816132
|
[
-1.4998784065246582,
1.8863036632537842,
-0.7894933819770813,
-0.5138548016548157,
-0.29090842604637146,
0.20616821944713593,
-1.038122296333313,
-0.851529061794281,
-0.05751432105898857,
0.7572610378265381,
-0.31844353675842285,
1.3084012269973755,
0.13928303122520447,
0.04151442274451256,
-0.49314939975738525,
0.4745618999004364,
-0.36653217673301697,
-0.2471490502357483,
1.1609408855438232,
-1.340714931488037,
0.507692277431488,
0.5136193037033081,
0.2890649437904358,
-0.4778386652469635,
-0.3736681640148163,
-1.760071039199829,
-1.045194387435913,
1.2258909940719604,
0.3683743476867676,
0.574903130531311,
-0.385347843170166,
0.04121331870555878,
-0.6358818411827087,
0.17695094645023346,
0.7642534971237183,
-0.673267662525177,
-0.41581249237060547,
-0.4657994210720062,
-2.284425735473633,
-0.034578073769807816,
0.8311991691589355,
0.34066933393478394,
-0.31081101298332214,
-0.20817430317401886,
0.7619928121566772,
0.9074507355690002,
-0.09209410101175308,
-0.6230579614639282,
0.3464528024196625,
-0.20441453158855438,
-0.10884588211774826,
0.4212227165699005,
0.3690166771411896,
-0.08243796229362488,
1.155029535293579,
0.31935083866119385,
0.18108776211738586,
0.12844295799732208,
0.6107978820800781,
-0.5201573371887207,
-0.17036227881908417,
1.3420132398605347,
-0.1258430778980255,
0.36150097846984863,
-0.5958048701286316,
-0.14180772006511688,
0.4058931767940521,
-0.17444077134132385,
-1.4027366638183594,
0.48705920577049255,
-1.0486193895339966,
-0.491617888212204,
0.024258675053715706,
-0.13779424130916595,
0.2777617871761322,
0.7341482043266296,
0.039904914796352386,
-0.28896602988243103,
-0.06578878313302994,
-0.04575638100504875,
-0.05104842036962509,
-0.21518203616142273,
-0.1576155573129654,
0.08011418581008911,
0.01921793259680271,
0.4161880612373352,
0.10928738862276077,
-0.20626913011074066,
0.14812666177749634,
-0.7329909205436707,
0.31261834502220154,
-0.28630128502845764,
-1.4891483783721924,
0.8191613554954529,
-0.2006610929965973,
-0.2552863359451294,
-0.8645560145378113,
-0.5490321516990662,
0.5306316614151001,
-0.4045502543449402,
-0.0007281070575118065,
-0.3402564227581024,
-0.09713929146528244,
-0.5535112619400024,
-1.2183583974838257,
0.5289157032966614,
-0.43491876125335693,
-0.7378191947937012,
-1.0257229804992676,
-0.11545033007860184,
0.43994057178497314,
-1.17440664768219,
0.30929917097091675,
-0.45831164717674255,
0.09706337749958038,
0.04245154187083244,
0.7379661798477173,
-0.1926541030406952,
-0.03154690936207771,
0.4089105427265167,
1.0782971382141113,
1.0877039432525635,
-0.10515707731246948,
0.0074837058782577515,
-0.7146868705749512,
-0.1112624779343605,
0.0801466703414917,
0.7217065691947937,
-0.05010077357292175,
-0.7241959571838379,
0.16483831405639648,
0.19540950655937195,
0.5610666871070862,
-0.6791662573814392,
-1.4055482149124146,
-0.6667023301124573,
0.13215523958206177,
1.4283429384231567,
0.3119100332260132,
-0.2712799906730652,
-0.3214298188686371,
0.3980264365673065,
0.2437746822834015,
0.19967509806156158,
-0.7814666628837585,
-0.7523979544639587,
-0.14875508844852448,
-0.19089536368846893,
-1.0548404455184937,
-0.137697234749794,
0.23746997117996216,
0.5102290511131287,
-0.007135620340704918,
0.23198488354682922,
-0.2356371134519577,
0.31259605288505554,
-0.39763638377189636,
0.22033639252185822,
0.31978464126586914,
-0.7959706783294678,
0.016146663576364517,
-0.4144522547721863,
0.599096953868866,
-0.6581911444664001,
0.25409767031669617,
-0.7310518026351929,
-0.36251673102378845,
-0.26189324259757996,
0.5977603793144226,
-0.5267964005470276,
-0.29237687587738037,
0.3149687945842743,
0.33983439207077026,
-0.07475127279758453,
-0.10687848925590515,
-0.11476616561412811,
0.7641990184783936,
-0.4150031507015228,
0.647678017616272,
-0.19498512148857117,
-0.056956950575113297,
-0.17337238788604736,
0.05808931216597557,
-0.5079669952392578,
-0.20731090009212494,
-0.8615128993988037,
-0.03465935215353966,
0.08352403342723846,
0.17141582071781158,
-0.03239813819527626,
0.11324460804462433,
-0.08367113023996353,
0.20220594108104706,
0.6051283478736877,
0.18977992236614227,
-0.14541509747505188,
-0.24150541424751282,
0.21131253242492676,
0.7295822501182556,
-0.46254345774650574,
0.5816730260848999,
0.20902125537395477,
-0.12188472598791122,
0.35050761699676514,
-0.06549832969903946,
0.053567662835121155,
0.3660878837108612,
0.05166328325867653,
-0.1256260871887207,
-0.10114453732967377,
0.15304528176784515,
-0.12738575041294098,
0.4540505111217499,
0.12997837364673615,
0.07694853097200394,
0.42256948351860046,
0.19959768652915955,
0.5272725820541382,
-0.10781087726354599,
-0.19804666936397552,
-0.24801106750965118,
-0.4555978775024414,
0.1313905417919159,
0.09449095278978348,
-0.23819707334041595,
0.14148691296577454,
-0.035175684839487076,
-0.11646775901317596,
0.24898861348628998,
0.015579631552100182,
-0.4713880717754364,
-0.3448709547519684,
-0.32545205950737,
0.04698191583156586,
-0.26540589332580566,
-0.1601320207118988,
0.2908826172351837,
-0.17021794617176056,
-0.1430278718471527,
0.17391684651374817,
-0.13091042637825012,
-0.49449270963668823,
0.030474791303277016,
-0.43280327320098877,
0.5150680541992188,
0.05440247058868408,
-0.11977764219045639,
0.01175149716436863,
0.21410569548606873,
0.13613101840019226,
-0.08872734755277634,
0.057517968118190765,
0.0019726366735994816,
0.02147795259952545,
0.06991107761859894,
-0.13800662755966187
] |
6,816,315 |
Tamoxifen alone versus tamoxifen plus 1-(2-tetrahydrofuryl)-5-fluorouracil in the treatment of advanced breast cancer: a sequential trial.
|
Wada T T, Koyama H H, Terasawa T T
|
Breast cancer research and treatment . Vol. 1, No. 1, 1981
|
During the past 4 years, a sequential study was conducted to compare the effect of tamoxifen (TAM) alone and TAM plus 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) in the treatment of advanced breast cancer. The overall response rates were 28.9% in 45 patients treated with TAM, and 43.2% in 37 treated with TAM + FT. In regard to dominant site of lesions, 4 out of 9 patients (44.4%) with visceral involvement responded to TAM + FT, whereas none out of 10 responded to TAM alone. In a crossover study, 4 out of 5 failures to TAM responded favorably to TAM + FT. The median value of survival was 24 months in patients treated with TAM alone and 36 months with TAM + FT. Side effects such as gastrointestinal disorders and bone marrow suppression slightly increased in incidence when cytotoxic chemotherapy was combined with TAM. The present chemo-endocrine regimen with TAM + FT showed some advantages over TAM alone.
|
https://pubmed.ncbi.nlm.nih.gov/6816315/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6816315
|
[
0.09160799533128738,
0.7591061592102051,
-0.6783385872840881,
-2.2294883728027344,
1.1658334732055664,
0.523855984210968,
1.1317802667617798,
-0.39170193672180176,
-0.9717814326286316,
0.8372932076454163,
-0.08460425585508347,
0.6046117544174194,
-0.6572533249855042,
-0.8243501782417297,
0.5357656478881836,
-0.1383572369813919,
-1.8239991664886475,
-0.5741481781005859,
0.9502981305122375,
-0.8300764560699463,
-0.20435857772827148,
-0.006409613881260157,
-0.6539415717124939,
-1.7080036401748657,
1.510149359703064,
-0.8767468929290771,
-0.4337705969810486,
0.8398778438568115,
-0.41979697346687317,
-0.045805636793375015,
0.2513316869735718,
0.2963908910751343,
0.8155987858772278,
-0.07871326059103012,
1.272641658782959,
-0.43516427278518677,
1.9820349216461182,
1.9472683668136597,
-1.838903546333313,
0.7313188910484314,
1.6166037321090698,
-0.08373784273862839,
0.5028936862945557,
-1.0349915027618408,
0.8171606063842773,
-0.2442197948694229,
0.5654743909835815,
0.3127274513244629,
0.45976394414901733,
0.4092969000339508,
-0.8381465077400208,
0.33611682057380676,
-0.24413448572158813,
-1.01857328414917,
1.3346174955368042,
0.7393324971199036,
0.33430051803588867,
0.48158425092697144,
-0.03770885244011879,
-0.6261434555053711,
0.3533950448036194,
1.1727486848831177,
-1.0572136640548706,
-0.04796549305319786,
-0.1963544338941574,
0.41221100091934204,
-1.2994216680526733,
0.34363576769828796,
0.012242424301803112,
2.1837735176086426,
1.1287410259246826,
1.6922500133514404,
1.3935037851333618,
-0.5177760124206543,
-0.06222299113869667,
-1.0813246965408325,
-0.3523577153682709,
0.856895923614502,
1.1434662342071533,
-0.17057931423187256,
-0.6759303212165833,
-0.03592988848686218,
-0.2541365921497345,
0.23403355479240417,
-0.38915902376174927,
-0.09178582578897476,
-0.3901483416557312,
-0.8527374863624573,
0.6720761060714722,
-1.8233473300933838,
0.005626385565847158,
-0.5040006041526794,
-1.603764533996582,
-0.4157598316669464,
-0.31129327416419983,
-0.46672508120536804,
0.44768503308296204,
-0.13335928320884705,
-0.34955453872680664,
-0.4449964463710785,
-0.1459488868713379,
-0.3090977072715759,
0.30267971754074097,
0.3269849717617035,
-0.5325594544410706,
-0.808854877948761,
-1.253183126449585,
-1.0206276178359985,
-1.5474244356155396,
-1.2892996072769165,
0.10323518514633179,
-0.896666944026947,
0.8102343082427979,
-0.9676888585090637,
0.18692676723003387,
0.2548110783100128,
0.2770385146141052,
0.21648921072483063,
-0.46593567728996277,
0.19057227671146393,
0.41834452748298645,
-0.6081732511520386,
-0.0607609897851944,
0.7436584830284119,
-0.8756933212280273,
0.2058756798505783,
0.059154488146305084,
0.10104025900363922,
-0.6762715578079224,
-0.6623427271842957,
0.5952110886573792,
-0.18621285259723663,
-0.8115656971931458,
0.8418696522712708,
-1.67049241065979,
-1.1810466051101685,
0.24930347502231598,
1.2284858226776123,
0.6697616577148438,
0.07848595827817917,
-0.2143378108739853,
0.38995441794395447,
0.20440852642059326,
-0.7370708584785461,
-1.8883554935455322,
0.22587117552757263,
-0.14838074147701263,
-0.051204435527324677,
-0.5680474638938904,
-0.5311798453330994,
-0.15144437551498413,
-0.15588179230690002,
0.45658308267593384,
-0.3593524694442749,
-0.27503910660743713,
0.03773314878344536,
0.11264180392026901,
-0.670232355594635,
-1.149869441986084,
-0.28499287366867065,
0.6048109531402588,
-0.35523781180381775,
0.4659534990787506,
-0.8400906920433044,
0.09958848357200623,
-0.28578439354896545,
0.038097452372312546,
-0.05071639642119408,
0.38953906297683716,
0.45122215151786804,
-0.9202803373336792,
0.4598703682422638,
0.12738631665706635,
0.443008154630661,
0.22127851843833923,
0.4402919411659241,
0.21263034641742706,
-0.18420468270778656,
0.2992604672908783,
0.33862119913101196,
0.18752306699752808,
0.24640758335590363,
0.2707657814025879,
-0.2818824350833893,
-0.48350465297698975,
0.019196799024939537,
0.2623766362667084,
-0.06750117242336273,
0.061250075697898865,
0.21812044084072113,
0.4095727801322937,
-0.103951096534729,
0.05905592069029808,
-0.012988988310098648,
-0.27986881136894226,
0.017781782895326614,
-0.009616274386644363,
0.3332129418849945,
0.35434460639953613,
0.38488060235977173,
0.18117472529411316,
-0.05654999241232872,
1.287363886833191,
0.7734301090240479,
-0.2549956440925598,
-0.2991931438446045,
-0.5229657888412476,
-0.06601876765489578,
-0.029049279168248177,
0.15683968365192413,
0.4539873003959656,
0.16044235229492188,
0.16148534417152405,
-0.15893520414829254,
-0.33661627769470215,
0.08977563679218292,
-0.2632054388523102,
-0.04524943605065346,
-0.9206644296646118,
0.7674391269683838,
0.30392584204673767,
-0.09814923256635666,
0.296508252620697,
-0.003671363228932023,
0.3281516432762146,
0.053722985088825226,
-0.3294737637042999,
-0.32059136033058167,
0.6092501878738403,
-0.1534663736820221,
-0.2902776300907135,
0.4527958631515503,
-0.3980349898338318,
-0.2980583608150482,
-0.056105662137269974,
0.24278628826141357,
-0.26576733589172363,
-0.2368294894695282,
0.5213217735290527,
0.13818466663360596,
-0.026940321549773216,
0.12840844690799713,
-0.40124472975730896,
-0.30708521604537964,
0.26863956451416016,
0.24933065474033356,
0.035392120480537415,
-0.1468881070613861,
0.7723708748817444,
0.04366374760866165,
-0.18670359253883362,
0.31789538264274597,
0.366849809885025,
0.608853816986084,
0.3850613534450531,
-0.1527133584022522
] |
6,816,316 |
Chemoendocrine therapy in advanced breast cancer.
|
Kiang D T DT, Kennedy B J BJ
|
Breast cancer research and treatment . Vol. 1, No. 2, 1981
|
The effect of a combination of endocrine and chemical therapies has been studied during the past decade in DMBA-induced rat mammary tumors and advanced human breast cancers. Although interferential effects have been observed between endocrine therapy and chemotherapy in highly hormone-dependent tumors or cell lines, beneficial effects can be achieved from a combination of these two treatment modalities in human breast cancer when the steroid receptor status and the presence or absence of visceral metastases are considered in the selection of treatment programs.
|
https://pubmed.ncbi.nlm.nih.gov/6816316/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6816316
|
[
1.4437824487686157,
1.2627817392349243,
-1.2900694608688354,
-1.5514469146728516,
-0.44395214319229126,
-0.5040767788887024,
-1.2280701398849487,
-0.5581375956535339,
-1.9135991334915161,
-0.466085284948349,
1.6859724521636963,
3.3272647857666016,
-0.5565721392631531,
-0.17516399919986725,
-0.2172544300556183,
0.5655291080474854,
-0.2942807674407959,
1.7574354410171509,
1.992404580116272,
-1.8806277513504028,
0.464944064617157,
-1.4833718538284302,
-0.8473411798477173,
-0.7240244746208191,
0.6306145787239075,
-0.5457208752632141,
-0.19489389657974243,
2.133561849594116,
1.287490725517273,
0.6186444163322449,
-1.0726017951965332,
-0.2564649283885956,
0.13547542691230774,
0.4521978199481964,
1.083731770515442,
-0.6364923715591431,
0.970778226852417,
-0.06145729124546051,
-1.7736464738845825,
0.05636287108063698,
0.8064625859260559,
0.5891249775886536,
1.0760040283203125,
-0.7511328458786011,
0.13958147168159485,
0.20476876199245453,
-0.3009156584739685,
0.2834027409553528,
1.761587381362915,
0.7936496138572693,
-0.3726385235786438,
1.4663949012756348,
-0.7567043900489807,
-0.7446455955505371,
1.852697730064392,
0.7280237674713135,
0.14782175421714783,
0.5252282023429871,
0.8634303212165833,
-1.2076820135116577,
0.8841267228126526,
-0.3790878653526306,
-1.497769832611084,
0.9330356121063232,
-0.8827089071273804,
-0.2765354514122009,
-0.3458973169326782,
0.12609118223190308,
-0.03770391643047333,
0.886822521686554,
1.285380482673645,
0.460834801197052,
0.7182651162147522,
0.07786093652248383,
1.3708853721618652,
0.083277627825737,
0.17539216578006744,
-0.10612911731004715,
1.8453704118728638,
-0.9384724497795105,
-0.3192599415779114,
-1.3863227367401123,
-0.4126017987728119,
-0.1686406284570694,
-0.5927484035491943,
0.18087123334407806,
-0.5502569079399109,
-0.4666658341884613,
0.41577836871147156,
-0.9068801999092102,
0.11711852997541428,
-0.35926735401153564,
-1.7169406414031982,
0.9106002449989319,
-0.5881168842315674,
1.3935112953186035,
0.21370068192481995,
-0.16768155992031097,
-0.13700860738754272,
-0.08324272930622101,
0.188388392329216,
0.9843839406967163,
-0.4309700131416321,
-0.24110659956932068,
-1.0158460140228271,
0.17025890946388245,
-0.36750176548957825,
-0.652885913848877,
-0.72128826379776,
-0.9090082049369812,
1.0803176164627075,
-1.357740044593811,
0.7792863845825195,
-1.3188649415969849,
0.16906459629535675,
0.6168991327285767,
0.08874151110649109,
0.0890410840511322,
-0.44822952151298523,
-0.5386951565742493,
0.5621505379676819,
-0.10839680582284927,
-0.050374533981084824,
0.9329849481582642,
-0.2592046558856964,
0.14105838537216187,
-0.5972633361816406,
0.42500412464141846,
-0.05074895918369293,
-0.6359452605247498,
-0.7722902894020081,
0.16488923132419586,
0.309925377368927,
-0.22104677557945251,
-1.2093533277511597,
-0.8425898551940918,
0.34857669472694397,
0.7372010350227356,
1.1498149633407593,
-0.2078593373298645,
0.020390363410115242,
0.332571417093277,
0.5137069821357727,
-0.045006584376096725,
-0.9491961598396301,
-0.36658453941345215,
0.41094663739204407,
1.2187508344650269,
-0.08505585044622421,
0.016951873898506165,
0.3216235041618347,
-0.0185846034437418,
0.0479922741651535,
-0.6380666494369507,
0.46175697445869446,
0.38239020109176636,
-0.37070104479789734,
0.030446847900748253,
-0.45929956436157227,
0.07421281188726425,
0.09547682851552963,
-0.00116339314263314,
-0.1501271277666092,
0.2004617303609848,
1.1834369897842407,
-0.09821779280900955,
0.6757335066795349,
0.07055462151765823,
0.3349774181842804,
-0.15997850894927979,
-0.5511922836303711,
-0.8734123706817627,
-0.17307977378368378,
0.4188581705093384,
-0.8197058439254761,
0.012226114980876446,
-0.3964175879955292,
-0.18396686017513275,
0.8023228645324707,
-0.5730838179588318,
0.16055917739868164,
0.1762431263923645,
0.8068988919258118,
-0.8062756061553955,
-0.16287310421466827,
-0.1566576510667801,
0.4318709075450897,
0.5446842312812805,
-0.07054173946380615,
-0.13249711692333221,
1.0130596160888672,
0.24017396569252014,
-0.022273026406764984,
0.28376075625419617,
-0.00462851719930768,
0.048363007605075836,
-0.7264411449432373,
0.37452831864356995,
0.6820277571678162,
0.016100073233246803,
-0.20220038294792175,
0.2285996526479721,
0.05098883435130119,
0.37490561604499817,
-0.16509829461574554,
-0.10284661501646042,
-0.10849225521087646,
-0.06028451770544052,
-0.19375517964363098,
0.2517157196998596,
-0.003035537898540497,
-0.12681908905506134,
0.21341130137443542,
0.44068124890327454,
0.23181888461112976,
0.5160952210426331,
-0.36759325861930847,
-0.09572979807853699,
-0.4742111265659332,
-0.4088078439235687,
-0.33514752984046936,
-0.0864429771900177,
0.24330230057239532,
0.17425626516342163,
0.2886401116847992,
0.4792070686817169,
-0.24318961799144745,
0.1113940104842186,
0.009382463991641998,
-0.38880255818367004,
-0.2281932681798935,
-0.53727787733078,
-0.12510329484939575,
-0.6435245871543884,
0.13419689238071442,
-0.3122061491012573,
0.13198061287403107,
0.014616619795560837,
-0.1362610161304474,
-0.21498365700244904,
0.42954492568969727,
-0.5792401432991028,
-0.3780050575733185,
-0.33117908239364624,
0.10212747007608414,
-0.2995503544807434,
0.09690439701080322,
0.10228817164897919,
0.3781503736972809,
-0.13292750716209412,
-0.8050631880760193,
0.14945363998413086,
0.2737760543823242,
0.2420976758003235,
-0.09208918362855911,
-0.4716742932796478
] |
6,816,333 |
Assessment of the accuracy and role of self-recorded blood pressures in the management of hypertension.
|
Gould B A BA, Kieso H A HA, Hornung R R, Altman D G DG, Cashman P M PM, Raftery E B EB
|
British medical journal (Clinical research ed.) . Vol. 285, No. 6356, 1982 Dec 11
|
Self-recording of the blood pressure by patients away from hospital or office ("home blood pressure") has been advocated as providing a better estimate of "true" blood pressure. The reliability of home blood-pressure recording has been assessed only by standard indirect methods which themselves are subject to considerable error and variability. The accuracy of self-recorded blood pressures was therefore assessed in 57 patients with essential hypertension by comparison with simultaneous measurements of clinic blood pressures and with intra-arterial blood pressures recorded at home and at hospital. Home systolic blood pressures showed good agreement with clinic and intra-arterial pressures, but home diastolic blood pressures overestimated intra-arterial pressures, as did clinic diastolic pressures. The clinic and home diastolic pressures showed good agreement. There was considerable variability in individual differences comparing the indirect and intra-arterial methods, though the two indirect methods showed much closer agreement. This study suggests that home blood pressures are as accurate as clinic readings but may be recorded more frequently and thus provide more useful information. Neither is likely to approximate the intra-arterial blood pressure.
|
https://pubmed.ncbi.nlm.nih.gov/6816333/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6816333
|
[
-1.4211235046386719,
3.446589231491089,
-1.2729272842407227,
-2.3472821712493896,
0.47022417187690735,
0.8433564305305481,
2.2514047622680664,
-0.5453618764877319,
-0.5630180835723877,
1.1242892742156982,
1.1211851835250854,
1.281592607498169,
1.03364098072052,
0.45148026943206787,
-1.732637882232666,
0.9033108949661255,
0.3774615526199341,
-0.5521076917648315,
0.6139750480651855,
-1.9789773225784302,
1.1200711727142334,
-0.6319987177848816,
0.23715180158615112,
-0.16944646835327148,
0.3744021952152252,
-0.23915408551692963,
0.8823711276054382,
0.04446753114461899,
-0.4373985826969147,
1.1432887315750122,
2.1541690826416016,
0.3535171151161194,
-0.5040001273155212,
1.222983956336975,
-0.685874879360199,
-2.1558947563171387,
0.7643381953239441,
1.0544438362121582,
-1.0194439888000488,
-0.9012083411216736,
2.9028053283691406,
1.4655070304870605,
-0.45210596919059753,
-0.531286895275116,
1.1532251834869385,
0.13720400631427765,
0.44576677680015564,
0.2944531738758087,
1.983104944229126,
1.392165184020996,
0.6029969453811646,
0.87281733751297,
-1.6702666282653809,
1.308639645576477,
1.867053747177124,
1.1537675857543945,
1.2216682434082031,
0.3926125764846802,
0.45218220353126526,
0.2021085023880005,
0.05314255133271217,
-0.6765395998954773,
0.6261563301086426,
1.2340645790100098,
-1.2213612794876099,
-0.061762597411870956,
0.7336848974227905,
0.4354120194911957,
-1.2004722356796265,
0.4540356993675232,
-0.7678588032722473,
0.7165086269378662,
0.6729434728622437,
0.12038604170084,
1.4769773483276367,
-0.6164762377738953,
-0.38854774832725525,
2.3047962188720703,
-0.7176005244255066,
1.843138337135315,
-1.0225811004638672,
0.3908931016921997,
-0.2780901789665222,
1.6743444204330444,
-0.48722440004348755,
0.9209610223770142,
0.09488054364919662,
-0.7774146199226379,
-0.0934506431221962,
-0.7556633949279785,
-1.532289743423462,
-0.04300619661808014,
-0.4463850259780884,
1.709910273551941,
-0.3327287435531616,
0.6160710453987122,
-0.3172512352466583,
-0.6337200999259949,
-0.701676070690155,
-0.08571592718362808,
0.7457783222198486,
-0.26556557416915894,
-0.8892068266868591,
1.169670581817627,
0.033504437655210495,
-0.7008265852928162,
0.9936231374740601,
-0.30285871028900146,
-0.7196941375732422,
-0.07210982590913773,
0.3427341878414154,
0.002884507644921541,
0.4014231860637665,
-0.32038259506225586,
-0.37098294496536255,
0.0482906848192215,
-0.032466862350702286,
-0.3469204604625702,
0.6482427716255188,
0.12908732891082764,
-0.6781577467918396,
1.4102122783660889,
0.42616358399391174,
1.4192919731140137,
-0.24394522607326508,
0.2069244682788849,
0.7158730030059814,
-0.5583956837654114,
-0.9485287070274353,
0.3538080155849457,
-0.07662619650363922,
0.669020414352417,
0.4682644307613373,
-0.17770011723041534,
-0.6050076484680176,
0.8966245651245117,
0.5129726529121399,
0.3143109977245331,
-0.6510587930679321,
-0.8793742656707764,
0.07457716763019562,
0.5248326063156128,
0.008350811898708344,
-0.011917791329324245,
-1.2154723405838013,
-0.18503764271736145,
-1.1693930625915527,
1.050503134727478,
-0.18810304999351501,
-0.5177465081214905,
-0.37334486842155457,
0.2886667251586914,
0.2199910283088684,
-0.84707111120224,
-0.5038845539093018,
-0.7042524814605713,
0.01668473519384861,
0.13631801307201385,
-0.34681734442710876,
-0.3650578558444977,
-0.8033174872398376,
0.4421670436859131,
-0.852340579032898,
-0.2513553500175476,
1.1665955781936646,
0.007251630537211895,
-0.4617132246494293,
-0.4310324192047119,
0.7654904127120972,
0.4757673144340515,
-0.7570792436599731,
0.6586116552352905,
0.08969447761774063,
0.9556840658187866,
-0.5856704115867615,
-0.07079873979091644,
0.5440982580184937,
0.4755364954471588,
0.6869057416915894,
-1.2177269458770752,
0.001170179806649685,
0.4308100938796997,
0.7266004085540771,
0.07845456153154373,
-0.008407723158597946,
-0.2135336846113205,
-0.3256264925003052,
-0.29196086525917053,
-0.18727761507034302,
-0.6774327754974365,
-0.7037141919136047,
0.2250303477048874,
-0.40264004468917847,
-0.04766860231757164,
-0.4171481430530548,
0.04441279545426369,
-0.89594966173172,
-0.032814860343933105,
0.030790505930781364,
-0.37394651770591736,
-0.10173869878053665,
0.1575067788362503,
0.1302267163991928,
0.23948776721954346,
-0.31592047214508057,
-0.4296693801879883,
-0.39360398054122925,
-0.3596825897693634,
-0.5086084604263306,
0.8276857733726501,
-0.08469487726688385,
-0.1740536242723465,
0.6411842703819275,
-0.20657359063625336,
0.07362097501754761,
-0.09553734958171844,
0.9094089269638062,
-0.2517179846763611,
-0.0036918874830007553,
-0.46234914660453796,
0.26617419719696045,
-0.18047086894512177,
0.4294971525669098,
0.12416016310453415,
0.07721325755119324,
0.34748467803001404,
0.8800138831138611,
0.7803332209587097,
0.04330381751060486,
-0.3407231569290161,
0.05421783775091171,
-0.36045604944229126,
0.3275965452194214,
-0.06680010259151459,
0.08597176522016525,
-0.060256924480199814,
-0.046646758913993835,
0.13406293094158173,
-0.33143067359924316,
0.2356230467557907,
0.05857410281896591,
0.34166601300239563,
0.3043115735054016,
-0.12734252214431763,
-0.16253425180912018,
0.6580109596252441,
-0.3147664964199066,
-0.3382419943809509,
0.5335573554039001,
-0.5355244874954224,
0.12223351746797562,
0.5166149735450745,
0.3975922763347626,
0.2503976821899414,
0.0701710432767868,
-0.44599032402038574
] |
6,816,343 |
Oesophageal transit of six commonly used tablets and capsules.
|
Hey H H, Jørgensen F F, Sørensen K K, Hasselbalch H H, Wamberg T T
|
British medical journal (Clinical research ed.) . Vol. 285, No. 6356, 1982 Dec 11
|
The oesophageal transit of six commonly used tablets and capsules containing barium sulphate was evaluated radiologically using fluoroscopy in 121 healthy volunteers. To determine the influence of the subject's position and the amount of water taken each subject swallowed three preparations while recumbent and standing and with 25 ml or 100 ml of water. Failure of swallowing (defined as oesophageal transit taking more than 90 seconds) occurred in 22% of 726 swallowings, but globus was complained of in only 33% of these. Sixty per cent of the volunteers had difficulty in taking one or more of the preparations. Many preparations adhered to the oesophageal membrane and started to disintegrate in the lower part of oesophagus. It is recommended that subjects should remain standing for at least 90 seconds after taking capsules or tablets and that all preparations should be taken with at least 100 ml of water. Small tablets are swallowed most easily. Liquid forms of medication (suspensions) should be considered for bedridden patients and those who have difficulty in swallowing.
|
https://pubmed.ncbi.nlm.nih.gov/6816343/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6816343
|
[
-1.5115829706192017,
2.3844075202941895,
-1.0378295183181763,
-1.9297971725463867,
0.41253185272216797,
0.13796156644821167,
0.8342466354370117,
-0.6200064420700073,
-1.2947925329208374,
-0.41742730140686035,
0.04286437854170799,
1.0649992227554321,
0.16704268753528595,
-0.015600448474287987,
1.3444372415542603,
-1.3667271137237549,
0.18707314133644104,
-0.16853538155555725,
-0.22008222341537476,
-1.649086356163025,
1.5480583906173706,
0.3006884455680847,
-0.9395303726196289,
0.31712210178375244,
1.0234400033950806,
-0.5524457693099976,
0.021117763593792915,
0.08012208342552185,
0.17015501856803894,
0.982986569404602,
0.6822483539581299,
-0.5034855008125305,
0.38951796293258667,
-0.4587723910808563,
0.4349781572818756,
-0.14321325719356537,
0.4956184923648834,
0.6951581835746765,
-0.12382076680660248,
0.016615156084299088,
-0.45904380083084106,
0.11716758459806442,
-0.06129264086484909,
-0.6640976667404175,
0.8258860111236572,
0.6312946677207947,
0.6558138728141785,
0.8013558387756348,
0.13896358013153076,
0.8332417607307434,
-0.047765348106622696,
0.2743407189846039,
-0.3199702501296997,
-0.11380309611558914,
1.592512607574463,
-0.45704931020736694,
0.6171389818191528,
-0.36047542095184326,
1.5378923416137695,
-0.6140773892402649,
0.3376671075820923,
0.499447226524353,
0.1320929229259491,
-0.21314136683940887,
-0.35114991664886475,
-0.0572066605091095,
0.24149006605148315,
0.5433083772659302,
-0.6409799456596375,
0.5180420279502869,
-0.2763082683086395,
0.08889205008745193,
-0.1868337094783783,
0.11138340830802917,
0.5595141649246216,
0.3742166757583618,
0.6541458368301392,
0.5391064286231995,
0.6281086206436157,
-0.05096374452114105,
-0.4598226845264435,
1.3075298070907593,
-0.032139357179403305,
0.38869819045066833,
0.36051738262176514,
0.5666874647140503,
-0.5841715335845947,
-0.26738739013671875,
0.22782517969608307,
-0.8866124749183655,
0.42434149980545044,
-0.10177750885486603,
-1.8730041980743408,
0.7669001817703247,
-1.1513820886611938,
-0.00381556898355484,
0.7271089553833008,
-0.022844523191452026,
-0.6302034258842468,
0.3373049795627594,
0.18595710396766663,
-0.12501254677772522,
0.4029408395290375,
-0.39952361583709717,
-0.7833935618400574,
-0.10281886160373688,
-0.8199095726013184,
0.41386479139328003,
-0.7525300979614258,
-0.8365443348884583,
0.5689911246299744,
-0.2850256860256195,
-0.02213941141963005,
0.13181686401367188,
1.0493526458740234,
0.24450060725212097,
0.24249906837940216,
-0.5502506494522095,
-0.32514688372612,
-0.6297426819801331,
-0.1448083370923996,
0.8118059039115906,
-0.44019439816474915,
-0.3588360548019409,
0.5908463001251221,
-0.012055499479174614,
-0.07324104011058807,
0.06948165595531464,
0.12186206132173538,
0.6549650430679321,
-0.756841242313385,
-0.021324317902326584,
0.01613621599972248,
-0.17744970321655273,
-0.2758706510066986,
-0.2604828476905823,
0.15081797540187836,
0.4479294419288635,
-0.571427047252655,
-0.29771366715431213,
-0.04625493660569191,
0.2734995484352112,
-0.6142157912254333,
0.4773457646369934,
-0.6925694942474365,
0.35869327187538147,
-0.6773168444633484,
0.21640446782112122,
-0.24187742173671722,
0.10607542097568512,
-0.06513581424951553,
-0.017885342240333557,
-0.46633410453796387,
-0.011412429623305798,
0.13942153751850128,
0.22454114258289337,
0.6631547212600708,
0.46955186128616333,
0.16828404366970062,
-0.17307519912719727,
-0.33627375960350037,
-0.5287759304046631,
-0.0444791354238987,
-0.2567102909088135,
-0.011411605402827263,
-0.06960130482912064,
0.3569242060184479,
-0.49324989318847656,
0.40111052989959717,
0.3549019992351532,
-0.05762828141450882,
-0.02027914486825466,
0.13563822209835052,
0.2505190968513489,
0.06052977591753006,
-0.5285118222236633,
0.43502816557884216,
0.5739033818244934,
0.39572954177856445,
0.03937261924147606,
0.28471338748931885,
-0.32150503993034363,
-0.16473238170146942,
-0.7053903341293335,
-0.1713210642337799,
-0.37360644340515137,
0.10279984772205353,
0.30557867884635925,
-0.31764543056488037,
0.8112825155258179,
0.6495824456214905,
0.20256130397319794,
0.05178878828883171,
0.3482210636138916,
0.4428609013557434,
0.2458084672689438,
0.17888329923152924,
-0.326842337846756,
0.5193813443183899,
-0.0688571184873581,
0.24162667989730835,
0.27302736043930054,
0.16700072586536407,
0.2744360566139221,
0.013362154364585876,
-0.4273247718811035,
-0.15467533469200134,
0.27194225788116455,
-0.016953712329268456,
0.17176423966884613,
0.22863952815532684,
0.06967119872570038,
0.10387873649597168,
-0.3120754063129425,
0.006151286885142326,
-0.44657185673713684,
-0.03584565594792366,
0.3582870364189148,
-0.22883948683738708,
0.4428881108760834,
0.15179526805877686,
0.019832830876111984,
-0.4339398145675659,
0.09889115393161774,
-0.08253982663154602,
-0.16118502616882324,
0.44329696893692017,
0.14699380099773407,
-0.429717093706131,
-0.49500772356987,
-0.2241651862859726,
0.14588011801242828,
-0.3540881872177124,
-0.3120371699333191,
0.024046044796705246,
0.3158333897590637,
-0.2010890543460846,
0.1293608695268631,
0.255125492811203,
-0.29454565048217773,
0.08953101933002472,
-0.39115285873413086,
0.12214112281799316,
-0.4257570505142212,
0.46739256381988525,
-0.44290482997894287,
-0.23373819887638092,
0.6381781697273254,
0.07676317542791367,
-0.22590500116348267,
0.04074810817837715,
-0.4602575898170471,
-0.3754199743270874,
-0.014421124942600727,
0.05887869372963905,
-0.2510761022567749
] |
6,816,626 |
Long-term effects of a tube extension on bronchodilator treatment with pressurized aerosol.
|
Langaker K E KE, Hidinger K G KG
|
European journal of respiratory diseases . Vol. 63, No. 6, 1982 Nov
|
The long-term effects of a tube extension to the terbutaline sulphate aerosol were studied in 23 patients. The trial was of open, randomised, cross-over design, and compared the ordinary actuator with the tube extension over two 3-week periods. Lung function before and after bronchodilator was measured at the start of the trial, at the treatment cross-over and at the end of the trial. The mean baseline FEV1 value obtained following 3 weeks of treatment with the tube extension was significantly greater (P less than 0.05) than that following treatment with the ordinary actuator. Treatment with the latter, however, produced significantly greater FEV1 values than at the start of the trial (P less than 0.05). At home, the patients recorded symptoms daily, as well as PEF each morning and evening. With the tube extension, the increase in PEF was significantly larger (P less than 0.05) than with the ordinary actuator. There were no differences with regard to symptom score.
|
https://pubmed.ncbi.nlm.nih.gov/6816626/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6816626
|
[
-1.3397401571273804,
1.3700090646743774,
-1.4766018390655518,
-1.6232259273529053,
0.6714277863502502,
0.9372317790985107,
1.5259937047958374,
0.7120053172111511,
-0.8350380659103394,
-0.142647847533226,
-0.07555535435676575,
0.8739550113677979,
-0.016836684197187424,
-0.22915621101856232,
0.26730290055274963,
0.6444197297096252,
-1.4533922672271729,
0.2795827090740204,
0.007586067542433739,
-0.7710050940513611,
0.19970019161701202,
0.35262319445610046,
-0.15645276010036469,
0.7793356776237488,
-0.33416420221328735,
-0.30582383275032043,
-0.06457363814115524,
0.7145201563835144,
0.00793503224849701,
0.8484613299369812,
0.4141026437282562,
-0.3388609290122986,
0.36910027265548706,
-0.0877566859126091,
-0.43662798404693604,
-0.03533945605158806,
0.6094257831573486,
0.5489233136177063,
-0.11906712502241135,
-0.2895074486732483,
0.6411886215209961,
1.1765120029449463,
0.030947595834732056,
-0.4435604512691498,
1.6551692485809326,
0.19910956919193268,
-0.14924828708171844,
-0.14454078674316406,
-0.12168735265731812,
0.28256234526634216,
0.18645888566970825,
0.29176798462867737,
-0.14325310289859772,
-0.08102138340473175,
1.5804029703140259,
0.08947662264108658,
-0.4695560932159424,
0.359010249376297,
0.5522193908691406,
0.1544291377067566,
1.0680606365203857,
0.3210204541683197,
-0.28338637948036194,
-0.32815220952033997,
0.13259612023830414,
-0.19896633923053741,
0.485980749130249,
0.17555753886699677,
-0.5831825137138367,
0.18969455361366272,
0.21152174472808838,
0.15690313279628754,
0.5991671681404114,
0.023617655038833618,
-0.31820106506347656,
0.19883862137794495,
-0.15219376981258392,
0.0015474909450858831,
0.20077049732208252,
0.2616752088069916,
-0.4405803382396698,
-0.22376321256160736,
-0.6714645028114319,
0.004601584747433662,
-0.2292710393667221,
0.17528729140758514,
-0.40480685234069824,
-0.4853576123714447,
0.21052542328834534,
-0.8986630439758301,
0.16640225052833557,
-0.04177115112543106,
-0.6876881718635559,
0.740277111530304,
-0.15774498879909515,
-0.34746071696281433,
0.08474130183458328,
-0.08539525419473648,
-0.03546680510044098,
-0.36059504747390747,
0.5331969857215881,
-0.02680274471640587,
0.18031492829322815,
0.11505866050720215,
-0.8446984887123108,
-0.4798496961593628,
-0.32983022928237915,
-0.6043874025344849,
-0.5075294375419617,
-0.3752509355545044,
0.3519367575645447,
-0.5098455548286438,
-0.1050383672118187,
-0.6033545136451721,
0.18588650226593018,
0.1957499235868454,
0.09306919574737549,
0.0034344925079494715,
-0.4464680552482605,
-0.15405315160751343,
-0.23905184864997864,
-0.1420688033103943,
0.12358452379703522,
0.6613714694976807,
-0.04990014806389809,
0.02416500821709633,
0.3917958438396454,
0.9525954723358154,
-0.47390758991241455,
-0.6018425822257996,
-0.004707925952970982,
-0.1915852129459381,
-0.15380902588367462,
-0.4311676323413849,
-0.4285401999950409,
-0.7855290770530701,
-0.26254209876060486,
0.5784041285514832,
0.00890884269028902,
-0.21478642523288727,
-0.09758933633565903,
0.5547447204589844,
-0.22076456248760223,
0.2507404088973999,
-0.6705156564712524,
0.4038456678390503,
0.07738091796636581,
-0.10687900334596634,
-0.8199084997177124,
0.045716553926467896,
-0.31774184107780457,
0.33412957191467285,
0.3808251619338989,
0.20458094775676727,
0.0345773883163929,
0.6501089334487915,
0.20238478481769562,
0.3641494810581207,
0.09676121920347214,
-0.0807734802365303,
0.5482369661331177,
-0.06898526847362518,
-0.0574413500726223,
0.17132236063480377,
0.2784275412559509,
-0.12274274230003357,
-0.008055547252297401,
-0.5676469802856445,
0.01923389546573162,
-0.5407031774520874,
-0.5213293433189392,
-0.30323395133018494,
0.2881263792514801,
0.3466130495071411,
-0.08414792269468307,
0.2002517431974411,
1.0118721723556519,
0.22851994633674622,
0.576635479927063,
-0.4128663241863251,
-0.1764400601387024,
-0.14022371172904968,
0.04669567942619324,
0.29845505952835083,
-0.027521129697561264,
-0.9202191233634949,
-0.45021072030067444,
-0.2782745659351349,
0.3465496003627777,
0.27489835023880005,
-0.05127333849668503,
0.22447733581066132,
-0.2379322350025177,
0.13909175992012024,
0.38342565298080444,
-0.25843074917793274,
-0.05524570867419243,
0.0708376094698906,
0.4600774645805359,
-0.2698476016521454,
0.22736729681491852,
0.4041520357131958,
0.2368253916501999,
0.5387689471244812,
0.08181700855493546,
-0.166492760181427,
-0.1677350252866745,
0.1152166873216629,
-0.17408405244350433,
0.10955504328012466,
0.4526371359825134,
-0.13080836832523346,
0.34151265025138855,
-0.11871232837438583,
0.1400223970413208,
-0.0018810391193255782,
0.11831021308898926,
0.13432317972183228,
-0.3096904456615448,
-0.30634963512420654,
-0.3895719647407532,
-0.36913636326789856,
0.5009456872940063,
-0.1332891881465912,
0.004882900509983301,
-0.7772842645645142,
0.08943814784288406,
0.6739156246185303,
0.021872328594326973,
0.08899184316396713,
-0.7021157145500183,
-0.25654464960098267,
0.03370111808180809,
-0.6057131886482239,
-0.4102950692176819,
-0.18136920034885406,
0.1299324780702591,
0.15570448338985443,
-0.13870476186275482,
0.1329994946718216,
0.08955574780702591,
-0.357393354177475,
-0.0359874926507473,
-0.4252646863460541,
-0.15184234082698822,
-0.05821094661951065,
-0.10271802544593811,
0.5936822295188904,
0.18441930413246155,
-0.2608632743358612,
0.2662951648235321,
-0.40088585019111633,
-0.020005883648991585,
0.17969556152820587,
0.037946149706840515,
-0.07856837660074234
] |
6,817,270 |
The Frey syndrome: a simple, effective treatment.
|
Hays L L LL, Novack A J AJ, Worsham J C JC
|
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery . Vol. 90, No. 4
|
The benign but socially embarrassing problem of gustatory sweating and flushing (Frey syndrome) has been studied in the past in search of a simple but effective treatment. Twenty-two patients participated in clinical trials of glycopyrrolate on an investigational basis, 17 of which have been followed up for four to five years. Double-blind comparisons of the efficacy and side effects of topical scopolamine (solution and cream) and glycopyrrolate (roll-on lotion, solution, and cream) are also presented. The use of 1% glycopyrrolate roll-on lotion and cream were associated with an average of three days of complete control of gustatory sweating and a remarkably low incidence of side effects.
|
https://pubmed.ncbi.nlm.nih.gov/6817270/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, U.S. Gov't, Non-P.H.S."
] |
6817270
|
[
-1.5098130702972412,
1.268694281578064,
-0.6903879046440125,
-1.8080017566680908,
-0.5537931323051453,
0.3151501417160034,
-0.41965121030807495,
-1.148472547531128,
-0.27567058801651,
0.020050067454576492,
0.6469406485557556,
1.3468421697616577,
0.7554680109024048,
0.37427276372909546,
0.37751123309135437,
-0.7347098588943481,
-0.5621188282966614,
0.2639872431755066,
0.5301920175552368,
-0.817190945148468,
0.33397865295410156,
0.05256161093711853,
-0.4902157187461853,
0.9670345187187195,
0.5325405597686768,
-1.2612982988357544,
0.11739969253540039,
0.7683405876159668,
0.5267462134361267,
0.6101921796798706,
-0.5145622491836548,
-0.23674272000789642,
0.6129078269004822,
-0.3656935691833496,
-0.4019622504711151,
-0.7461997270584106,
0.3598630130290985,
-0.558319091796875,
-0.7747173309326172,
-0.4392019510269165,
0.5353251099586487,
-1.0545754432678223,
-0.6507101058959961,
-0.07056961953639984,
1.2783262729644775,
0.5435174107551575,
-0.46589377522468567,
0.9109651446342468,
-0.5596781969070435,
0.14019368588924408,
0.4506213963031769,
0.11746708303689957,
-0.10655869543552399,
0.00829620286822319,
1.3676018714904785,
0.009163903072476387,
0.1423928588628769,
0.5927596092224121,
0.5340427160263062,
-0.8746746182441711,
0.12097209692001343,
0.06426195800304413,
-0.3367179036140442,
-0.3856029510498047,
-0.10071408003568649,
-0.11184486746788025,
0.16024096310138702,
-0.4140874743461609,
-0.7136781811714172,
0.07722585648298264,
-0.38471171259880066,
0.7264741063117981,
-0.1718711405992508,
-0.10598941892385483,
0.024746865034103394,
0.5132967829704285,
0.09962520003318787,
0.25282585620880127,
0.6803566217422485,
-0.08260580897331238,
-0.3058217167854309,
-0.09228671342134476,
-0.5960056185722351,
-0.7516640424728394,
-0.3015648126602173,
-0.2819766104221344,
-0.02777651511132717,
-0.44220688939094543,
-0.08653970062732697,
-0.8094540238380432,
-0.4561479091644287,
-0.23611119389533997,
-0.6617347002029419,
1.2241407632827759,
-0.14949892461299896,
-0.19866366684436798,
-0.1621371954679489,
-0.023988384753465652,
-1.1958941221237183,
0.7373537421226501,
-0.12030835449695587,
-0.27138179540634155,
-0.10536360740661621,
-0.646056592464447,
-0.930177628993988,
-0.3248678147792816,
-1.125232458114624,
-0.21894371509552002,
-0.6772788166999817,
-0.6294400691986084,
0.45043256878852844,
-0.2175101786851883,
0.12945502996444702,
0.0473925955593586,
1.2141369581222534,
0.6349148154258728,
0.4502907693386078,
0.2148427963256836,
-0.8084303736686707,
-0.22569088637828827,
0.08281204849481583,
-0.05505577474832535,
-0.23702970147132874,
0.4618932604789734,
0.12102597951889038,
0.1374896764755249,
0.21583013236522675,
0.3170156478881836,
-0.19700202345848083,
-0.5477070808410645,
-0.9345870614051819,
0.3481583893299103,
0.19781765341758728,
-0.36660870909690857,
-1.1377034187316895,
0.23701390624046326,
0.6290872097015381,
1.2273728847503662,
0.19308292865753174,
-0.24253568053245544,
-0.3217819333076477,
-0.030118228867650032,
0.023093996569514275,
0.19134286046028137,
-1.3318816423416138,
0.21243420243263245,
-0.5571153163909912,
-0.14661334455013275,
-0.6509184241294861,
-0.17056094110012054,
0.37822142243385315,
0.04465615376830101,
0.15293048322200775,
0.2318113148212433,
0.6316782832145691,
0.07635849714279175,
0.8995310068130493,
-0.14190253615379333,
0.21617130935192108,
0.1250719279050827,
0.3354271352291107,
-0.3203257620334625,
0.31999197602272034,
-0.4828655421733856,
-0.04534171521663666,
-0.3270530104637146,
-0.08866167813539505,
-0.7514848113059998,
-0.19818297028541565,
-0.02340037189424038,
-0.5648530125617981,
0.0069822571240365505,
-0.23465561866760254,
0.4282885789871216,
-0.24519136548042297,
0.6238719820976257,
0.1719464361667633,
-0.24727340042591095,
0.6021247506141663,
0.013121376745402813,
-0.6733595132827759,
-0.2393016219139099,
-0.20461931824684143,
0.4673984944820404,
-0.5956607460975647,
-0.5403966903686523,
0.01823098212480545,
0.03522217646241188,
0.15879270434379578,
0.3275241255760193,
0.042642638087272644,
0.176918625831604,
0.15045571327209473,
-0.2108573168516159,
-0.3315446972846985,
-0.20715731382369995,
0.2998265326023102,
-0.021720366552472115,
0.10817251354455948,
-0.3427504897117615,
-0.04471863433718681,
0.2809683382511139,
0.09794938564300537,
0.11235605925321579,
-0.10120054334402084,
0.014424487948417664,
0.10237720608711243,
0.06884073466062546,
-0.37294483184814453,
0.316300630569458,
0.06710208207368851,
-0.19677141308784485,
-0.11404786258935928,
0.1665361225605011,
0.2707972824573517,
0.16973836719989777,
0.34967461228370667,
0.14253048598766327,
-0.4490693509578705,
-0.1025133952498436,
-0.12991560995578766,
0.0028644620906561613,
-0.09917531907558441,
-0.27945369482040405,
-0.29150906205177307,
0.11025337874889374,
-0.056988395750522614,
0.19494087994098663,
0.23661255836486816,
-0.01888093911111355,
-0.5124986171722412,
0.023957913741469383,
-0.19993622601032257,
-0.23522411286830902,
-0.19097384810447693,
0.3563065826892853,
0.1894659548997879,
0.29476210474967957,
0.16392943263053894,
-0.2638901472091675,
-0.09385736286640167,
-0.475604772567749,
0.16729705035686493,
-0.0041228667832911015,
0.15648873150348663,
-0.00998461153358221,
-0.07869915664196014,
0.17842061817646027,
0.24967893958091736,
-0.020524486899375916,
-0.2826875150203705,
-0.23922784626483917,
0.29054000973701477,
0.24825643002986908,
-0.3103886544704437,
-0.35698866844177246
] |
6,817,370 |
REM sleep suppression induced by selective monoamine oxidase inhibitors.
|
Cohen R M RM, Pickar D D, Garnett D D, Lipper S S, Gillin J C JC, Murphy D L DL
|
Psychopharmacology . Vol. 78, No. 2, 1982
|
The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent of stage 2 sleep. Clorgyline also increased awake time and decreased total recording period and sleep latency. In general, changes were greater for clorgyline than for pargyline and were about 50% slower to return to baseline after clorgyline compared to pargyline discontinuation. The results were consistent with the hypothesis that selective inhibition of the MAO type A, as produced by clorgyline, is sufficient to induce marked sleep changes. MAO inhibitor-induced receptor changes are proposed to account for the time course of the REM suppression and the REM rebound observed upon withdrawal.
|
https://pubmed.ncbi.nlm.nih.gov/6817370/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6817370
|
[
-1.5991700887680054,
1.049608588218689,
-1.0741699934005737,
-2.672715187072754,
1.0563101768493652,
-1.1657330989837646,
-0.08065854012966156,
-0.6693766117095947,
-0.09340158104896545,
-0.01637140102684498,
0.6785869598388672,
1.4104424715042114,
-1.4539263248443604,
-0.13203079998493195,
0.28510791063308716,
-0.23096169531345367,
-0.9490007758140564,
-0.9113049507141113,
1.0154688358306885,
-1.8581979274749756,
0.584727942943573,
-1.694350004196167,
-0.7554006576538086,
-1.1147481203079224,
0.5910306572914124,
-0.8184482455253601,
0.3754444718360901,
1.0653506517410278,
-0.10983715951442719,
0.48688602447509766,
0.20220394432544708,
-1.4646424055099487,
0.2922823429107666,
-0.2898707687854767,
-0.006739343982189894,
-0.4212695062160492,
-0.15126341581344604,
-0.9919988512992859,
-1.7449170351028442,
-0.12866497039794922,
-0.09887592494487762,
0.6336338520050049,
0.4055333137512207,
-1.270930528640747,
1.3326395750045776,
0.726756751537323,
0.3017774820327759,
0.6268768310546875,
1.9147117137908936,
0.08190783113241196,
-0.5191091895103455,
0.9307910203933716,
-0.5270631313323975,
-1.869724988937378,
0.8336635231971741,
-0.04839622974395752,
-0.6659284234046936,
-0.15020984411239624,
0.3935893476009369,
-0.28201255202293396,
0.27911484241485596,
0.6247344613075256,
0.2905783951282501,
1.5214701890945435,
-2.4472928047180176,
-0.6261798143386841,
1.374454379081726,
-0.1269054412841797,
-0.10079625993967056,
1.0824286937713623,
-0.48652827739715576,
-1.0505856275558472,
0.42933323979377747,
-0.025931132957339287,
0.36221984028816223,
0.5187440514564514,
-0.6559422016143799,
0.9866734743118286,
0.09076471626758575,
-0.28863441944122314,
-1.163050889968872,
-0.3644540011882782,
-0.749365508556366,
-0.8188682794570923,
-0.29981380701065063,
-0.658664882183075,
-0.19262272119522095,
-1.1018733978271484,
0.29914936423301697,
-0.9583565592765808,
1.1950633525848389,
-0.8542459011077881,
-0.6561870574951172,
0.2358839213848114,
0.19371894001960754,
0.9454497694969177,
-0.006811218336224556,
0.6897240877151489,
-0.599438488483429,
0.3559976816177368,
0.871597945690155,
-0.2484685331583023,
-0.4053475260734558,
0.5231226086616516,
-0.11644551903009415,
-0.4072605073451996,
-0.7267187833786011,
-0.4959859549999237,
-0.2261800616979599,
-0.30223122239112854,
-0.19516591727733612,
-0.7387887239456177,
-0.336027592420578,
-1.0415863990783691,
0.22398917376995087,
1.2583178281784058,
0.1358179897069931,
0.24229152500629425,
-0.21080762147903442,
-0.42740264534950256,
0.8678240776062012,
0.5314694046974182,
-0.0055958181619644165,
1.6018421649932861,
-0.5643089413642883,
-0.6351488828659058,
-0.3785332441329956,
-0.9505876302719116,
-0.4739733934402466,
-0.6301082968711853,
0.22910940647125244,
-0.07735120505094528,
0.054845795035362244,
-0.9641956090927124,
-0.812339723110199,
-0.5540492534637451,
-0.3606683611869812,
1.1021236181259155,
0.14735591411590576,
-0.48645803332328796,
-0.7136120796203613,
0.48725512623786926,
-0.42937377095222473,
0.014470918104052544,
-1.0811139345169067,
-0.33303606510162354,
0.2644515931606293,
0.18583068251609802,
-0.3384636342525482,
0.8202679753303528,
0.1690603643655777,
1.151956558227539,
0.759648859500885,
-0.1112266331911087,
-0.23308920860290527,
0.0873328298330307,
-0.33891427516937256,
0.15600575506687164,
0.4575279951095581,
-0.2342209815979004,
0.5044596791267395,
-0.2332632690668106,
-0.17507584393024445,
0.1338910460472107,
0.6782671809196472,
0.12210439890623093,
0.4407404363155365,
-0.34725338220596313,
0.01161227561533451,
-0.4595116376876831,
-0.7741329073905945,
0.4178485870361328,
0.2149292379617691,
0.4548715353012085,
-0.9026029109954834,
-0.26743799448013306,
0.15397430956363678,
0.2756424844264984,
0.15554770827293396,
0.10365759581327438,
0.010299710556864738,
-0.1055479422211647,
-0.35410118103027344,
-0.34106236696243286,
-0.004605145659297705,
-0.011430241167545319,
0.5935661196708679,
-0.23730021715164185,
0.5240767598152161,
-0.07627806812524796,
0.09419608861207962,
0.145143523812294,
0.39910560846328735,
-0.6369760036468506,
0.20911678671836853,
0.5390263199806213,
-0.08253976702690125,
-0.41981783509254456,
0.0633172020316124,
-0.06509728729724884,
-0.47342467308044434,
1.0502177476882935,
-0.030749883502721786,
0.37958964705467224,
-0.030219491571187973,
-0.20197051763534546,
-0.17893044650554657,
0.39179351925849915,
0.08523029088973999,
-0.12719355523586273,
0.0937974825501442,
-0.10457956045866013,
0.23539771139621735,
0.607695996761322,
0.1385200470685959,
0.29237908124923706,
0.006284739822149277,
-0.22688591480255127,
-0.08145167678594589,
-0.20037682354450226,
-0.05466626212000847,
-0.1618833839893341,
-0.4691948890686035,
0.26692330837249756,
-0.09443476051092148,
-0.27323082089424133,
-0.11059597879648209,
0.3725718855857849,
0.3500238060951233,
0.03382730111479759,
-0.509473443031311,
-0.32411596179008484,
0.12173417210578918,
-0.4708944857120514,
0.44805940985679626,
0.1166577935218811,
-0.6208388805389404,
-0.31997987627983093,
0.3155144155025482,
-0.11575192213058472,
0.1339748501777649,
-0.6030562520027161,
-0.5398877263069153,
-0.07557766884565353,
0.4620758295059204,
-0.303906112909317,
0.15388625860214233,
0.05996755510568619,
-0.2576315402984619,
-0.04806442931294441,
0.24644500017166138,
-0.2977936267852783,
0.30072885751724243,
0.036029502749443054,
0.16382049024105072,
0.05066531524062157
] |
6,817,438 |
Approaches to the stabilization of interferons.
|
Sedmak J J JJ, Grossberg S E SE
|
Texas reports on biology and medicine . Vol. 41
|
Considerable effort has been expended in the past few years toward establishing an armamentarium of different techniques to stabilize naturally produced alpha-and beta-interferons, particularly the beta type in view of its greater lability. Of the techniques reported, it seems that addition of various proteins, rare earth salts, and use of acid pH conditions may be the most useful since they are relatively nontoxic and protect against both thermal and mechanical stress inactivation. Little has so far been reported on the stability of recombinant DNA-derived interferons. It is unlikely that they will be any more stable when they are purified than the natural human interferons. To generate stable preparations of these bacteria-produced interferons for clinical use it is important to establish different nontoxic techniques and approaches to prevent inactivation of these interferons during preparation, processing, concentration, purification and storage.
|
https://pubmed.ncbi.nlm.nih.gov/6817438/
|
[
"Clinical Trial",
"Journal Article",
"Research Support, U.S. Gov't, P.H.S."
] |
6817438
|
[
-0.058111269026994705,
2.335977792739868,
-2.7751667499542236,
-3.3459837436676025,
0.4855077564716339,
-0.6523628830909729,
-0.798088788986206,
-1.1657488346099854,
-1.2095458507537842,
0.19881564378738403,
-0.29228389263153076,
1.1426198482513428,
-0.32620278000831604,
0.8957983255386353,
-0.670955240726471,
0.4764515161514282,
-1.092956304550171,
0.05489011108875275,
0.5649614930152893,
-1.5120584964752197,
0.7430736422538757,
0.27817457914352417,
0.4275324046611786,
0.0843522921204567,
0.2475200742483139,
0.915219783782959,
-0.32420429587364197,
-0.7667965888977051,
0.4783460199832916,
-0.3541625738143921,
-0.13077794015407562,
-0.19889375567436218,
0.27277350425720215,
-0.1789850890636444,
0.44892069697380066,
0.30091527104377747,
0.6673824787139893,
0.363469660282135,
-0.5093750357627869,
-0.5531538128852844,
0.7138493061065674,
0.6256741881370544,
0.35619717836380005,
-0.1519101858139038,
0.7021146416664124,
-0.10732610523700714,
1.2153668403625488,
-0.05775631219148636,
-0.03586844354867935,
-0.6559935808181763,
-0.9932148456573486,
0.6760232448577881,
0.03886223956942558,
0.6091148853302002,
1.3501383066177368,
0.03268110379576683,
-0.022568080574274063,
0.13326826691627502,
0.21431471407413483,
0.11666808277368546,
0.3530181050300598,
-0.35593652725219727,
-0.8497808575630188,
-0.2843224108219147,
-1.059507131576538,
-1.2774536609649658,
0.20772741734981537,
0.22808441519737244,
-0.8344515562057495,
0.5376623272895813,
-0.06819842755794525,
-0.3714601397514343,
0.019005490466952324,
0.8864774703979492,
0.019882233813405037,
-0.12646877765655518,
-0.26001161336898804,
0.12186053395271301,
0.15386515855789185,
0.11153675615787506,
-0.4222501814365387,
-0.6455977559089661,
0.18562966585159302,
0.3523404598236084,
0.48027607798576355,
0.0938277468085289,
-0.852874755859375,
-0.5662356615066528,
0.23980385065078735,
0.5092417001724243,
0.2622077167034149,
0.31478944420814514,
-1.5327789783477783,
0.5596620440483093,
0.4735451638698578,
-0.3981693983078003,
-0.36985355615615845,
-0.39740467071533203,
0.785495400428772,
0.34023547172546387,
-0.37489646673202515,
-0.45447486639022827,
-1.1278083324432373,
0.1752500683069229,
-0.03667043522000313,
-0.13205431401729584,
-0.47266486287117004,
-0.21033909916877747,
-0.11015793681144714,
-0.6726648807525635,
-0.5797390937805176,
-0.10124358534812927,
0.2653641104698181,
0.09313639998435974,
0.3126302659511566,
0.3440132141113281,
-0.472290575504303,
-0.5708110928535461,
0.03113028220832348,
0.3428366780281067,
0.19663609564304352,
0.3545006811618805,
1.121732473373413,
0.746786892414093,
-0.6609408259391785,
0.640079915523529,
0.38886773586273193,
0.3133184313774109,
0.025312423706054688,
-0.14999668300151825,
-0.4100631773471832,
0.4239555597305298,
-0.07654628902673721,
-0.8643480539321899,
-0.3575024902820587,
0.3732353150844574,
0.5386265516281128,
0.7665266394615173,
-0.06802602857351303,
0.17633755505084991,
-0.804362416267395,
0.0015689420979470015,
0.37795594334602356,
0.006530981045216322,
-0.38034766912460327,
-0.37838616967201233,
-0.3285866677761078,
0.20657648146152496,
-0.16490298509597778,
0.18697640299797058,
-0.6656855344772339,
0.39558032155036926,
0.1191016361117363,
0.19687621295452118,
0.43579787015914917,
0.44525253772735596,
0.31516221165657043,
-0.4580758213996887,
0.023343775421380997,
0.4710710942745209,
-0.013666271232068539,
0.39908188581466675,
-0.3176294267177582,
0.40804076194763184,
-0.024926496669650078,
-0.7336271405220032,
0.36966755986213684,
0.013541976921260357,
0.501834511756897,
-0.243375763297081,
-0.6559128165245056,
-0.6952299475669861,
-0.0972265973687172,
-0.2851399779319763,
-0.07608649879693985,
0.02896558865904808,
0.5028187036514282,
0.5340906381607056,
0.023513132706284523,
-0.47451967000961304,
-0.14018115401268005,
0.11904002726078033,
-0.11356623470783234,
0.13596408069133759,
0.11308251321315765,
-0.03869524225592613,
-0.4006561040878296,
0.22803045809268951,
-0.38049715757369995,
-0.011861231178045273,
-0.06522846966981888,
0.5854880809783936,
-0.5654625296592712,
-0.17743851244449615,
0.01664438098669052,
0.07105446606874466,
-0.012771408073604107,
-0.041489869356155396,
0.07952607423067093,
-0.06747172772884369,
0.33855757117271423,
-0.11256442219018936,
0.2330573946237564,
0.06541387736797333,
-0.02733570523560047,
0.0534084290266037,
0.08507542312145233,
0.31206291913986206,
0.4949624240398407,
0.5380211472511292,
-0.3744330406188965,
0.29692503809928894,
1.0139094591140747,
0.18819531798362732,
-0.09452106058597565,
0.42847293615341187,
-0.054300107061862946,
0.5062685608863831,
-0.6232225298881531,
-0.3983002007007599,
-0.2237449288368225,
-0.124773770570755,
0.2874145209789276,
-0.28000012040138245,
-0.3975028693675995,
0.024348538368940353,
0.7998983860015869,
-0.1978210061788559,
0.16045275330543518,
0.25840604305267334,
-0.44124430418014526,
0.24706405401229858,
-0.47372087836265564,
0.028422893956303596,
0.17914658784866333,
-0.3905441462993622,
0.1363748461008072,
-0.03715886175632477,
0.19065465033054352,
-0.22722592949867249,
-0.14405736327171326,
-0.09337657690048218,
-0.18078553676605225,
-0.08084886521100998,
-0.15397195518016815,
-0.08722830563783646,
0.06257759779691696,
-0.2803129255771637,
0.22827064990997314,
0.3032100200653076,
0.40343278646469116,
-0.2174604833126068,
-0.03608375042676926,
-0.21109335124492645,
0.012066279537975788,
-0.20188984274864197
] |
6,817,658 |
Protective effect of disodium cromoglycate on propranolol challenge.
|
Koëter G H GH, Meurs H H, de Monchy J G JG, de Vries K K
|
Allergy . Vol. 37, No. 8, 1982 Nov
|
The protective activity of cromoglycate in histamine and propranolol bronchial provocation tests was studied in seven asthmatic patients by inhalation of increasing doses of histamine and propranolol in the absence and presence of inhaled cromoglycate. Cromoglycate showed a significant protective effect on the propranolol challenge, whereas no protection against histamine challenge could be observed.
|
https://pubmed.ncbi.nlm.nih.gov/6817658/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6817658
|
[
-1.0381450653076172,
-0.6894659996032715,
-2.112682342529297,
-2.6520910263061523,
0.73675537109375,
0.30320751667022705,
0.4171416759490967,
2.0162131786346436,
-2.2099294662475586,
0.8109543919563293,
1.0209482908248901,
0.505266010761261,
-0.31533801555633545,
0.6549796462059021,
0.6588822603225708,
-0.05811639130115509,
-0.21923628449440002,
1.7223784923553467,
1.4579192399978638,
-1.7079236507415771,
1.6810503005981445,
-2.9794833660125732,
-0.4081757664680481,
-0.5986637473106384,
0.9883625507354736,
0.5607746839523315,
-0.6711091995239258,
0.19095247983932495,
1.0886341333389282,
1.4617353677749634,
-1.2863519191741943,
-0.9539024829864502,
0.5628650188446045,
-0.29506543278694153,
0.019066911190748215,
0.6449510455131531,
-0.05403970181941986,
-0.8259267807006836,
0.4004153907299042,
-0.7784358263015747,
-0.2186317890882492,
-0.49794426560401917,
1.5142766237258911,
-2.7234766483306885,
0.9718039631843567,
0.4454972743988037,
0.8269401788711548,
0.29012808203697205,
-0.10235198587179184,
-0.5325874090194702,
-1.350363850593567,
1.2153637409210205,
0.5899506211280823,
-0.4972274601459503,
0.9501760005950928,
0.1022329330444336,
1.592352271080017,
0.6628116369247437,
0.8117650151252747,
0.43122512102127075,
0.22073370218276978,
0.42675596475601196,
1.4059085845947266,
0.42802363634109497,
-1.059349536895752,
0.24697637557983398,
-0.5316681861877441,
-0.04793620854616165,
-1.917498230934143,
-0.8383728265762329,
0.13613419234752655,
0.6578307151794434,
-1.7534942626953125,
-0.08546025305986404,
0.9227088689804077,
1.543005108833313,
1.9059817790985107,
0.8077178597450256,
0.17419441044330597,
0.4280095100402832,
-1.1077996492385864,
-1.086018443107605,
-0.6491727828979492,
0.6590077877044678,
-0.7745127081871033,
-0.4421623945236206,
0.10074764490127563,
-1.0458863973617554,
0.10408971458673477,
-1.1541675329208374,
-0.9291919469833374,
-0.742183268070221,
-1.5664565563201904,
1.4282513856887817,
0.14418669044971466,
0.26578110456466675,
-0.020979981869459152,
-0.3279684782028198,
-0.5882892608642578,
-0.4600405991077423,
0.5911499857902527,
-0.7776503562927246,
0.9971478581428528,
0.5898911356925964,
-0.5534718632698059,
0.9810558557510376,
-0.7092339396476746,
-0.5539883971214294,
-1.815110445022583,
-1.3734939098358154,
-0.17506614327430725,
-0.568781852722168,
0.2564932703971863,
-1.3364864587783813,
0.8643607497215271,
0.4175123870372772,
-0.9791816473007202,
-0.4939209818840027,
-0.9041690230369568,
-0.06162075698375702,
-1.0836553573608398,
1.1465164422988892,
0.31679680943489075,
1.2689343690872192,
0.10749398171901703,
-0.07004717737436295,
0.49036890268325806,
0.06289000064134598,
0.007868079468607903,
-0.6150946021080017,
-0.7725855708122253,
-0.1827739179134369,
0.25493907928466797,
-1.1171458959579468,
-1.8235878944396973,
-0.7372756600379944,
1.0187594890594482,
-0.34706634283065796,
0.10661491006612778,
0.07756397128105164,
-0.6394608020782471,
0.15334665775299072,
-0.5551649332046509,
0.2229834347963333,
-0.254321426153183,
0.2089209109544754,
0.08454316854476929,
0.879177987575531,
0.6196074485778809,
0.005959697999060154,
0.1538386195898056,
0.7716882824897766,
0.8898810148239136,
-0.7482053637504578,
0.46291878819465637,
0.5381196737289429,
1.0444841384887695,
-0.1403065025806427,
-0.1761634796857834,
0.06069498509168625,
0.7497917413711548,
-0.7308061718940735,
0.6453830003738403,
0.1118144765496254,
0.8893977999687195,
-0.32366645336151123,
0.9131274819374084,
-0.9225888252258301,
0.46571579575538635,
-0.6072035431861877,
-0.9578924775123596,
-0.9255892038345337,
-0.0918472558259964,
-0.8692078590393066,
0.14177283644676208,
-0.5779923796653748,
0.7425869703292847,
0.4857029914855957,
0.048471465706825256,
-0.4085172414779663,
-0.12349002808332443,
0.2158963680267334,
-0.9086858630180359,
-0.3511362075805664,
-0.015058735385537148,
-0.1718958020210266,
-0.15293163061141968,
-0.42048394680023193,
0.5992607474327087,
0.12861716747283936,
0.5618020296096802,
-0.4729703366756439,
-0.22873646020889282,
-0.4271416962146759,
0.48384857177734375,
-0.006360578816384077,
-0.33292004466056824,
0.22074805200099945,
0.2922457158565521,
-0.8408064842224121,
0.16316990554332733,
0.4012683928012848,
-0.15256817638874054,
0.5853034257888794,
0.07081358879804611,
0.21158254146575928,
-0.05119478330016136,
-0.15551896393299103,
-0.9284022450447083,
-0.15290145576000214,
-0.12147963792085648,
0.15502820909023285,
0.32877790927886963,
-0.7810556888580322,
0.5957586169242859,
-0.18661381304264069,
-0.15265880525112152,
-0.06674925237894058,
-0.1478072851896286,
0.2746991217136383,
0.49805620312690735,
-0.45069754123687744,
-0.10430838912725449,
0.053988561034202576,
-0.5498254895210266,
-0.13691005110740662,
0.12458037585020065,
0.5777232050895691,
-0.22654779255390167,
-0.5188207626342773,
-0.21708205342292786,
-0.0701594203710556,
-0.8538956046104431,
-0.4255634546279907,
0.14853693544864655,
0.8010629415512085,
-0.6472808122634888,
-0.16389970481395721,
-0.024503488093614578,
0.15960060060024261,
-0.591656506061554,
-0.44487714767456055,
-0.4133373498916626,
0.03334945812821388,
0.9023780226707458,
0.018464406952261925,
0.29772940278053284,
0.06833191215991974,
0.0407911017537117,
-0.017021704465150833,
-0.17476725578308105,
0.34457796812057495,
-0.4147914946079254,
0.14240559935569763,
0.1045280322432518,
0.19941353797912598
] |
6,817,771 |
A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.
|
Robinson J F JF, Doogan D P DP
|
British journal of clinical pharmacology . Vol. 14, No. 6, 1982 Dec
|
1 Fluvoxamine and clovoxamine, two new potential antidepressants were given to 27 healthy male volunteers in a double-blind, placebo controlled, three-way crossover study. 2 Neither compound affected the electrical intervals of 24 h ambulant electrocardiographic monitoring with the exception of a small increase in R-R interval. 3 There were no changes in blood pressure measurements. 4 The only notable unwanted symptom was nausea for both fluvoxamine and clovoxamine.
|
https://pubmed.ncbi.nlm.nih.gov/6817771/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6817771
|
[
-0.42257630825042725,
0.5994299650192261,
-1.3042184114456177,
-2.7428762912750244,
1.2254353761672974,
0.37900033593177795,
1.6274349689483643,
-0.9505454301834106,
0.21855777502059937,
1.6809725761413574,
-0.8027248382568359,
1.6499232053756714,
-0.7272369861602783,
-0.9982311725616455,
1.026953935623169,
-0.8417714238166809,
-1.7536931037902832,
-0.608023464679718,
1.4186890125274658,
-1.9402121305465698,
0.044404350221157074,
-1.0013647079467773,
-1.532437801361084,
-0.868057906627655,
-0.36418721079826355,
-0.42119428515434265,
0.9888458847999573,
1.0504858493804932,
-0.25849518179893494,
-0.26047244668006897,
-0.3116791546344757,
-0.9236941933631897,
1.0366917848587036,
-0.2722122371196747,
1.3653944730758667,
-0.6064913272857666,
0.9427780508995056,
1.1969728469848633,
-1.4439888000488281,
-0.32581913471221924,
0.6680953502655029,
0.5537609457969666,
0.44045987725257874,
0.9330535531044006,
2.0954136848449707,
-1.1108845472335815,
-0.7478007674217224,
0.5558624863624573,
2.1456010341644287,
0.7014287710189819,
-1.1887974739074707,
0.8202997446060181,
0.09801086783409119,
-0.325819194316864,
2.439162492752075,
0.5245535373687744,
0.007574525661766529,
0.30781906843185425,
0.06349217891693115,
-0.44507282972335815,
0.028561074286699295,
0.12111551314592361,
0.3138790428638458,
1.2622336149215698,
-1.4408310651779175,
1.589141845703125,
-0.41737616062164307,
-0.6064414978027344,
-0.7311146855354309,
1.344599962234497,
-0.338497132062912,
1.0007565021514893,
0.5017789602279663,
-0.3868018388748169,
-0.48191410303115845,
0.8977603912353516,
-0.8816019296646118,
1.0662556886672974,
1.353689432144165,
0.13112510740756989,
-1.682252287864685,
-0.40800631046295166,
-0.7762805223464966,
-0.3197651207447052,
-0.2024385929107666,
0.07730523496866226,
-0.6974678635597229,
-0.41921406984329224,
0.36665433645248413,
-1.01572847366333,
0.18513931334018707,
0.5886361598968506,
-0.37402647733688354,
-0.1684766709804535,
-0.3178936839103699,
0.1002650335431099,
0.633588433265686,
0.9007992148399353,
-0.012088479474186897,
-0.14616188406944275,
0.4140472412109375,
-0.3332352936267853,
-1.03005051612854,
-1.230907917022705,
-0.9526655673980713,
-0.27737754583358765,
-0.3384571373462677,
-0.5936357975006104,
0.1703079342842102,
-0.21673928201198578,
0.06060749292373657,
0.32407376170158386,
-0.4284088909626007,
0.26431357860565186,
0.7350045442581177,
1.0507878065109253,
0.2511075437068939,
0.38455790281295776,
-0.09567825496196747,
0.194784015417099,
0.6277639865875244,
0.49549946188926697,
-0.5045615434646606,
-0.3642994463443756,
0.8704959154129028,
0.28086668252944946,
0.24290946125984192,
-0.21808534860610962,
0.21523499488830566,
-1.436867356300354,
-0.8002660274505615,
0.3324393928050995,
-0.5954751372337341,
-1.1241093873977661,
-0.7546569108963013,
-0.6095665097236633,
0.12013138830661774,
0.6365097761154175,
0.4569670259952545,
-0.30680352449417114,
-0.1953863948583603,
0.32267844676971436,
0.04077625647187233,
-0.14813439548015594,
-0.31629741191864014,
-0.4413701295852661,
0.8462210893630981,
-0.15234801173210144,
-0.25108787417411804,
0.7219902276992798,
0.09185363352298737,
0.7456969022750854,
0.25614407658576965,
-0.7294505834579468,
0.05626324936747551,
-0.3656200170516968,
-0.279633104801178,
0.06122623383998871,
0.24421896040439606,
0.12190579622983932,
0.12552165985107422,
-0.6936197280883789,
-0.5002352595329285,
-0.23514991998672485,
-0.11412865668535233,
0.5943291783332825,
-0.06478063762187958,
-0.29205000400543213,
0.9828649759292603,
-0.7821274995803833,
-0.09552982449531555,
0.2795569896697998,
0.14233990013599396,
-0.08080635964870453,
0.013196198269724846,
0.1926605999469757,
0.09773862361907959,
-0.11059708148241043,
-0.06261524558067322,
-0.18553537130355835,
-0.22009548544883728,
-0.5080907940864563,
-0.3182142376899719,
-0.30184412002563477,
-0.515497624874115,
-0.47904494404792786,
0.3116198182106018,
-0.3100909888744354,
-0.23012596368789673,
0.011990806087851524,
-0.6389585733413696,
0.05827002972364426,
-0.38875463604927063,
-0.8015567064285278,
0.7885513305664062,
0.02377828024327755,
-0.17551247775554657,
0.42352786660194397,
0.38106095790863037,
0.32475364208221436,
-0.30362367630004883,
0.21893024444580078,
-0.2713928818702698,
0.30647140741348267,
-0.2523486912250519,
0.05720806494355202,
-0.43012040853500366,
0.17390590906143188,
0.07371041178703308,
0.21593235433101654,
-0.15764950215816498,
0.18816953897476196,
0.17930231988430023,
0.08691367506980896,
-0.34141287207603455,
0.12262972444295883,
-0.04955468699336052,
-0.26165515184402466,
0.2763878405094147,
0.17797592282295227,
0.13958674669265747,
-0.022369561716914177,
-0.37527215480804443,
-0.4032386541366577,
0.1399170160293579,
0.2399904876947403,
0.2609029710292816,
-0.09367116540670395,
0.20078100264072418,
-0.07803300023078918,
-0.38389283418655396,
-0.23974961042404175,
0.1436835378408432,
-0.399090975522995,
-0.12993136048316956,
0.20823273062705994,
-0.6407842636108398,
-0.1318538337945938,
0.2939893901348114,
0.10916981101036072,
0.06205423176288605,
-0.35841602087020874,
-0.11239326000213623,
-0.6670130491256714,
0.007793329656124115,
-0.23518727719783783,
0.0008513116627000272,
-0.4905012249946594,
0.14047886431217194,
0.0725102573633194,
-0.5862082242965698,
0.255950391292572,
0.3124864399433136,
0.34372109174728394,
-0.6278254389762878,
-0.4125938415527344
] |
6,817,772 |
The effect of glyceryl trinitrate ointment on heart rate--corrected systolic time intervals in angina pectoris.
|
Struthers A D AD, Whiting B B, Hillis W S WS, Kelman A W AW
|
British journal of clinical pharmacology . Vol. 14, No. 6, 1982 Dec
|
1 Individual systolic time intervals (STI) v heart rate regression equations were determined using small doses of intravenous atropine in seven patients with angina pectoris. 2 Regression lines of the form LVET = A + B.HR and QS2 = C + D.HR were calculated. There was no significant correlation between PEP and HR. The values of parameters A C and D were significantly different from a group of previously studied normal volunteers. 3 STI changes were recorded for 5 h after the application of GTN or placebo ointment. The active drug caused shortening of LVET and QS2 with the peak effect occurring between 105 and 180 min. After 180 min neither LVET nor QS2 were significantly shortened. There was no significant effect on PEP or heart rate.
|
https://pubmed.ncbi.nlm.nih.gov/6817772/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6817772
|
[
-0.04930399730801582,
2.1680245399475098,
-2.539135456085205,
-1.7936387062072754,
0.7623674273490906,
0.6593014001846313,
1.1743690967559814,
0.4181736409664154,
-0.46405264735221863,
0.04612961784005165,
-0.365016907453537,
0.7236024737358093,
-0.34245097637176514,
0.2105642408132553,
-0.5647164583206177,
-0.04451568052172661,
-0.5175803303718567,
-0.727763831615448,
0.9557590484619141,
-2.177490711212158,
-0.8995117545127869,
0.4314991235733032,
0.044754721224308014,
0.010858919471502304,
-0.12989908456802368,
-0.021494131535291672,
0.7321352958679199,
1.2167147397994995,
-0.5980249047279358,
1.4231104850769043,
0.5985193252563477,
-0.7616191506385803,
0.6583310961723328,
0.324564129114151,
0.7586398124694824,
-0.22979456186294556,
0.5882446765899658,
-0.657915472984314,
-0.2537296712398529,
-1.059723138809204,
0.695751965045929,
-0.025479460135102272,
0.34838739037513733,
-0.15003108978271484,
1.5119078159332275,
-0.1648576408624649,
-0.08630169928073883,
0.4541545510292053,
1.2872868776321411,
-0.44975465536117554,
-0.5007178783416748,
-0.08729464560747147,
-1.2955764532089233,
-0.21822047233581543,
1.0766563415527344,
0.048376455903053284,
0.34723272919654846,
-0.08515994250774384,
0.680134117603302,
-0.3884321451187134,
0.6510169506072998,
0.22622260451316833,
-0.2116142213344574,
0.33544495701789856,
0.3221006691455841,
-0.23983760178089142,
0.9574956297874451,
-0.18456891179084778,
-0.3396395742893219,
1.3479938507080078,
-0.17248810827732086,
0.18172109127044678,
0.16056720912456512,
0.3209937810897827,
0.2663935720920563,
0.35170790553092957,
-1.0202131271362305,
1.1589220762252808,
0.5963445901870728,
0.8819117546081543,
-0.5248236656188965,
-0.7732733488082886,
-0.4717758297920227,
0.14690883457660675,
0.5832058191299438,
0.14291569590568542,
-0.7237082719802856,
0.1815333366394043,
0.13917379081249237,
-0.7415213584899902,
-0.30727458000183105,
-0.16882359981536865,
-1.3409518003463745,
-0.33376574516296387,
-0.26124507188796997,
0.5570665001869202,
0.03894273564219475,
0.21795527637004852,
-0.2736888825893402,
0.1951194405555725,
0.30206435918807983,
0.45716536045074463,
0.0763532817363739,
0.16888615489006042,
-0.22383877635002136,
-0.719144344329834,
0.02054435946047306,
-1.0496259927749634,
-0.4325982928276062,
0.3673768937587738,
0.3213440477848053,
-0.05569503456354141,
-0.5935869216918945,
-0.5757632255554199,
0.38016441464424133,
0.21593305468559265,
-0.37272730469703674,
-0.3952300250530243,
-0.33214041590690613,
-1.2167754173278809,
0.20082199573516846,
0.08134259283542633,
0.021606789901852608,
0.8645841479301453,
-0.469570517539978,
-0.24609357118606567,
0.9302839040756226,
0.32429781556129456,
-0.26257187128067017,
0.015548748895525932,
-0.9398815035820007,
0.6790247559547424,
-0.02354654297232628,
-0.4525448977947235,
-0.5321835875511169,
-0.30049487948417664,
-0.353661447763443,
0.5283471345901489,
0.7268661260604858,
0.08019521087408066,
-0.17614713311195374,
0.12339098006486893,
-0.4733436703681946,
0.13490967452526093,
-0.37857985496520996,
-0.436874121427536,
-0.7529047727584839,
0.6679750680923462,
-0.7905074954032898,
0.046138618141412735,
-0.49238458275794983,
-0.3157559931278229,
0.24872080981731415,
-0.6251691579818726,
-0.3881976008415222,
-0.04673464968800545,
0.7576520442962646,
0.2829831838607788,
-0.01566636934876442,
-0.20574450492858887,
0.45867446064949036,
-0.05676579102873802,
-0.3501640558242798,
0.18089240789413452,
0.5967008471488953,
0.07752090692520142,
-0.15579235553741455,
-0.09378521144390106,
0.4168986678123474,
-0.30737563967704773,
-0.4104277491569519,
0.31180307269096375,
0.3167879581451416,
0.9884293079376221,
-0.256673127412796,
-0.03652200102806091,
0.0645400732755661,
0.1854621022939682,
0.3036545515060425,
0.04092663899064064,
-0.05692533776164055,
-0.12283316999673843,
0.43769675493240356,
0.0708186998963356,
0.4420630633831024,
-0.5494276881217957,
0.13113431632518768,
0.03768175095319748,
0.21570709347724915,
-0.067668616771698,
0.06263048946857452,
0.33116787672042847,
0.08880961686372757,
0.03047524020075798,
0.5260401368141174,
0.40202635526657104,
-0.31388020515441895,
0.0006779233226552606,
0.523625910282135,
-0.1660802811384201,
-0.05767425149679184,
0.7467789053916931,
0.4721154272556305,
0.5055806636810303,
0.05044883117079735,
-0.08117903769016266,
-0.6365755200386047,
0.8214851021766663,
-0.006465679965913296,
0.314908504486084,
0.2861166000366211,
-0.6535478830337524,
-0.4876731038093567,
0.23072309792041779,
0.5368099808692932,
0.1567874401807785,
0.11251509189605713,
-0.10998772829771042,
-0.2691897749900818,
0.03898773714900017,
-0.048156846314668655,
-0.5941163301467896,
-0.03637290745973587,
0.06535704433917999,
-0.15543381869792938,
-0.2705690562725067,
0.28459659218788147,
-0.05083953216671944,
0.33314475417137146,
0.0616542287170887,
-0.36258405447006226,
0.035941749811172485,
0.3471682071685791,
-0.11528293043375015,
0.1892603486776352,
-0.1340598613023758,
-0.3396818935871124,
0.2031206637620926,
-0.1920752078294754,
-0.13713596761226654,
0.2428559511899948,
-0.8088997602462769,
-0.2710985839366913,
0.26857054233551025,
0.23638300597667694,
0.09860466420650482,
-0.07370331883430481,
-0.05617773160338402,
0.07329447567462921,
-0.5983128547668457,
0.3560166656970978,
-0.27355632185935974,
-0.14675553143024445,
0.42138010263442993,
-0.2740212678909302,
-0.015847044065594673
] |
6,817,776 |
A double-blind clinical trial of ketotifen and disodium cromoglycate in bronchial asthma.
|
Monie R D RD, Smith A P AP, Leopold D D, Anderson G G, Davies B H BH, Thomas G O GO
|
British journal of diseases of the chest . Vol. 76, No. 4, 1982 Oct
|
A double-blind cross-over trial compared the efficacy of ketotifen (1 mg b.d.) and DSCG (20 mg q.d.s.) as prophylactic therapy for asthma. It involved two eight-week periods of active therapy, each being preceded by two weeks of double placebo treatment. Analysis of symptoms recorded on diary cards showed that there was a reduction in the cough score in the atopic asthmatics on DSCG compared to ketotifen, and reductions in the cough score, wheeze and dyspnoea on DSCG when compared with placebo. There was a significant reduction in the diurnal variation in PEFR during treatment with DSCG compared to ketotifen and improvement in morning PEFR on DSCG compared with placebo. It was concluded that DSCG resulted in a significant therapeutic effect during the trial, whereas ketotifen (1 mg b.d.) did not.
|
https://pubmed.ncbi.nlm.nih.gov/6817776/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6817776
|
[
0.6040647029876709,
0.7163376212120056,
-2.0797014236450195,
-3.0198256969451904,
0.8632006645202637,
-0.18660709261894226,
0.5911267399787903,
0.7731653451919556,
-0.77872633934021,
0.2983089089393616,
0.37091711163520813,
1.0072215795516968,
0.15116427838802338,
-0.21096189320087433,
-0.1266251802444458,
-0.4976159334182739,
-0.23724453151226044,
-0.3583339750766754,
1.413878083229065,
-1.2694206237792969,
-0.3546040654182434,
-0.11180140823125839,
-0.29521796107292175,
0.006876075174659491,
0.2442566305398941,
-0.6778213381767273,
0.17375729978084564,
2.3354361057281494,
-0.778984785079956,
1.604317545890808,
-0.07166500389575958,
-0.560524046421051,
0.158950075507164,
0.22682060301303864,
0.04528625309467316,
-0.43509432673454285,
0.42552512884140015,
-0.21022680401802063,
-0.4611869752407074,
-0.2871518135070801,
0.3795772194862366,
0.5894227623939514,
0.10411867499351501,
-0.8472482562065125,
1.0205899477005005,
0.2905438542366028,
1.095521330833435,
0.1246095821261406,
-1.1997175216674805,
-0.8562526106834412,
0.2026955485343933,
0.8764951825141907,
-0.78173828125,
-0.08627858012914658,
1.944783329963684,
0.09866301715373993,
0.2976115643978119,
0.7214858531951904,
1.0587527751922607,
-0.04062890261411667,
-0.023527570068836212,
-0.16593687236309052,
-0.1125347688794136,
0.06363097578287125,
0.05837897211313248,
-1.4586762189865112,
-0.06403011083602905,
0.0006656593177467585,
-0.13415445387363434,
0.24750779569149017,
0.07865744084119797,
0.6081708073616028,
0.4861736297607422,
-0.07859968394041061,
0.9131192564964294,
-0.432420551776886,
0.20161764323711395,
0.6992003321647644,
0.7831960320472717,
0.7440769076347351,
-0.06075436249375343,
-0.25951915979385376,
-0.41564449667930603,
0.20723867416381836,
-0.5835273265838623,
-0.20380042493343353,
-0.6309724450111389,
-0.0929308831691742,
0.01341956201940775,
-0.7865050435066223,
-0.11994355916976929,
-0.032674018293619156,
-1.3079415559768677,
0.3354959785938263,
-0.781358003616333,
0.047638311982154846,
-0.40911149978637695,
-0.04458553344011307,
-0.3024655878543854,
-0.35072892904281616,
0.3515881299972534,
-0.15227851271629333,
0.11295062303543091,
0.47072848677635193,
-1.1961658000946045,
-0.24757999181747437,
-0.27666598558425903,
-0.7554522752761841,
-0.7293529510498047,
-0.801405131816864,
0.2908816635608673,
-1.1376041173934937,
0.5188905000686646,
0.14973869919776917,
0.9889227151870728,
1.6182459592819214,
0.4731314480304718,
-0.019951241090893745,
-0.2711239159107208,
0.48702359199523926,
0.1673135608434677,
0.9705600738525391,
0.5308384895324707,
1.317989706993103,
-0.4059406518936157,
0.8244783282279968,
-0.05361846461892128,
0.5603571534156799,
-0.7697557210922241,
-0.25420689582824707,
-0.04639069363474846,
0.0806800127029419,
0.020173387601971626,
-0.49968117475509644,
-1.3013269901275635,
-0.8494884371757507,
0.17089685797691345,
1.2040103673934937,
0.20839424431324005,
-0.3587760329246521,
-0.5915671586990356,
0.1807069629430771,
0.3101811110973358,
-0.029220938682556152,
-0.7773532867431641,
-0.3755916655063629,
-0.46252885460853577,
0.44214606285095215,
-0.9224582314491272,
0.16519510746002197,
-0.059253815561532974,
0.6314879059791565,
0.196415513753891,
-0.31774598360061646,
-0.15870589017868042,
0.6285349726676941,
0.2163495272397995,
0.1479952484369278,
0.12071400135755539,
-0.5173743963241577,
0.3839527666568756,
0.005606635939329863,
0.6260530352592468,
-0.03182225301861763,
0.32473957538604736,
0.1620953232049942,
-0.24390743672847748,
-0.45139068365097046,
-0.07283245772123337,
-0.21019241213798523,
-0.5054718255996704,
0.13276800513267517,
0.2564668655395508,
0.7181715369224548,
-0.23915541172027588,
0.4989345073699951,
0.2620810866355896,
0.013899443671107292,
0.3835669159889221,
-0.7154015898704529,
-0.21488894522190094,
-0.1822124719619751,
-0.5136094689369202,
-0.24798956513404846,
-0.12802964448928833,
-0.5936548113822937,
-0.5200203657150269,
0.13858254253864288,
0.026640208438038826,
0.39203211665153503,
-0.6197714805603027,
0.3948896825313568,
0.22128857672214508,
0.10394277423620224,
-0.019875839352607727,
-0.4724389910697937,
-0.0968398004770279,
0.22763003408908844,
0.49036940932273865,
-0.39990800619125366,
0.30447274446487427,
0.08873950690031052,
0.08165860176086426,
0.195024311542511,
0.22837743163108826,
-0.3304908871650696,
-0.5892752408981323,
0.34666356444358826,
-0.5113505125045776,
0.15053121745586395,
0.3773767352104187,
-0.22529971599578857,
-0.06536796689033508,
0.37166640162467957,
-0.08820374310016632,
0.2912057638168335,
-0.054162584245204926,
0.46948423981666565,
0.1556617170572281,
-0.20326146483421326,
-0.3303526043891907,
-0.04051719233393669,
0.4702657461166382,
0.15605489909648895,
-0.05826191231608391,
0.17808683216571808,
0.11039425432682037,
0.16449898481369019,
-0.19631794095039368,
-0.08063744008541107,
-0.7863503694534302,
-0.5261204242706299,
-0.27869758009910583,
-0.47757795453071594,
-0.18439103662967682,
0.10370681434869766,
0.49059757590293884,
0.8903439044952393,
0.1359894871711731,
0.5198512077331543,
-0.14214470982551575,
-0.5946636199951172,
-0.3067830204963684,
-0.19855745136737823,
-0.1207059770822525,
0.1213100254535675,
-0.34579718112945557,
-0.2159212827682495,
0.14953553676605225,
-0.24039427936077118,
0.12000446766614914,
-0.33923768997192383,
-0.2521955072879791,
0.15471528470516205,
-0.028977045789361,
-0.33768174052238464
] |
6,817,833 |
The current status of primary radiation therapy in the treatment of early breast cancer.
|
Leslie N T NT, Harris J R JR, Hellman S S
|
Breast cancer research and treatment . Vol. 2, No. 3, 1982
|
Primary radiation therapy, usually with limited surgery, is being used increasingly as an alternative to mastectomy in patients with early breast cancer. Results so far appear similar in terms of local control and overall survival. Current questions on patient selection, extent of surgery, radiation therapy technique, possible long-term complications, and the role of axillary dissection and of adjuvant therapy are reviewed. Though many questions remain, it is hoped that this alternative will contribute to improved survival along with breast preservation for improved quality of life.
|
https://pubmed.ncbi.nlm.nih.gov/6817833/
|
[
"Clinical Trial",
"Journal Article",
"Review"
] |
6817833
|
[
-0.875562846660614,
3.2360100746154785,
-0.8805594444274902,
-1.4284436702728271,
-1.4946233034133911,
0.6098741292953491,
-0.9190844893455505,
0.28111034631729126,
-1.7784433364868164,
-0.27725252509117126,
0.6146693825721741,
1.1611769199371338,
-0.6810443997383118,
-0.155534029006958,
-0.5825104713439941,
1.2464147806167603,
0.14042294025421143,
0.28719520568847656,
-0.7160510420799255,
-0.6626259684562683,
0.6608991026878357,
-0.1872146725654602,
0.20066602528095245,
-0.09055367112159729,
0.2559411823749542,
0.5811499357223511,
-0.07651287317276001,
0.7345689535140991,
0.543228030204773,
0.6719579100608826,
-0.7592742443084717,
0.1626841127872467,
-0.42874521017074585,
0.43802714347839355,
0.44867947697639465,
0.4506765902042389,
0.38590970635414124,
0.2193860113620758,
-1.062656283378601,
0.4823438823223114,
1.3459898233413696,
-0.38844600319862366,
-0.6807373762130737,
-0.7288997769355774,
0.2870323359966278,
-0.06310389190912247,
0.018686380237340927,
-0.3175376355648041,
0.2854556143283844,
0.5623568296432495,
-0.7523408532142639,
1.140674352645874,
-0.0586562342941761,
-0.5806410312652588,
1.0256246328353882,
0.4202445447444916,
0.03360904008150101,
0.2979654371738434,
0.37604522705078125,
0.8444726467132568,
0.568008542060852,
-0.31696128845214844,
-0.3880085349082947,
0.7300012707710266,
-0.997417151927948,
-0.6972347497940063,
-0.3220672607421875,
0.32394352555274963,
0.6975998878479004,
0.5859332084655762,
0.9398804306983948,
-0.13471226394176483,
0.6418724656105042,
0.12794427573680878,
0.5309414267539978,
0.868842363357544,
0.1634911596775055,
0.3180638551712036,
0.3008764088153839,
-0.25341469049453735,
-0.08322563022375107,
-0.9555745124816895,
-0.5330514907836914,
0.4292354881763458,
-0.06670055538415909,
0.054205700755119324,
-1.2525079250335693,
-0.3752104938030243,
0.7477038502693176,
-0.879799485206604,
0.2254079431295395,
0.5401609539985657,
-0.9864605069160461,
0.9339062571525574,
-1.0968197584152222,
0.46513107419013977,
0.5034728050231934,
-1.1844797134399414,
-0.5692472457885742,
-1.3236873149871826,
-0.35900092124938965,
0.2906740605831146,
0.05539201945066452,
0.1598665863275528,
-0.6601787805557251,
-1.1512210369110107,
-0.332476407289505,
-0.6426165699958801,
0.7817032933235168,
-0.22370260953903198,
0.3204633295536041,
-1.9821866750717163,
1.0625848770141602,
-1.0564501285552979,
0.43372538685798645,
0.7222150564193726,
-0.008245901204645634,
-0.39091721177101135,
0.4030586779117584,
-0.22659142315387726,
-0.438512921333313,
0.5912670493125916,
0.22625523805618286,
0.3562224507331848,
-0.651515007019043,
-0.002565922914072871,
-0.8832845687866211,
1.415492057800293,
-0.17288227379322052,
0.013184738345444202,
0.3125828206539154,
-0.1975388377904892,
0.020792290568351746,
-0.5265193581581116,
-0.6246744394302368,
-0.5884742140769958,
-0.10362505167722702,
0.5258025527000427,
-0.01028018444776535,
-0.20016495883464813,
0.13463960587978363,
0.13716627657413483,
0.05383073911070824,
0.38260942697525024,
-1.2595535516738892,
-0.10231662541627884,
-0.05780991166830063,
0.5985571146011353,
-0.14536286890506744,
-0.6953765749931335,
-0.029209503903985023,
0.2580733299255371,
0.5988388061523438,
0.12087540328502655,
0.48628929257392883,
1.2601642608642578,
-0.009951566345989704,
-0.466655969619751,
-0.6991222500801086,
0.08238478749990463,
0.08504604548215866,
-0.16668875515460968,
0.0901004746556282,
-0.7874919176101685,
1.1555365324020386,
-0.6448855400085449,
0.4302346110343933,
-0.9205377697944641,
0.26709267497062683,
0.5519462823867798,
-0.7563986778259277,
-0.2576886713504791,
0.4888680577278137,
0.5927700996398926,
-0.6503399610519409,
-0.09348534792661667,
0.910423219203949,
-0.065363310277462,
0.6811956763267517,
-0.5646368265151978,
0.144779235124588,
-0.47944098711013794,
1.051546335220337,
0.165790393948555,
-0.35324984788894653,
-0.21798811852931976,
0.28885138034820557,
-0.31552985310554504,
0.34238192439079285,
-0.10580073297023773,
0.13956311345100403,
-0.09622152149677277,
0.03785403445363045,
0.6678169369697571,
0.30121079087257385,
-0.01229693554341793,
-0.7277933359146118,
-0.29387789964675903,
0.4677880108356476,
0.062057819217443466,
0.2522287964820862,
-0.005820698104798794,
-0.4882742762565613,
0.1671331375837326,
0.08424137532711029,
0.15273140370845795,
-0.013567788526415825,
-0.12722797691822052,
-0.5378574728965759,
-0.011444819159805775,
0.14183662831783295,
0.36437731981277466,
0.6140963435173035,
-0.2557050883769989,
-0.22929218411445618,
-0.13972166180610657,
0.6677857637405396,
0.2690966725349426,
-0.7015172839164734,
-0.4532354474067688,
-0.36112314462661743,
-0.06993620097637177,
0.44064417481422424,
0.5473949313163757,
-0.11081068217754364,
0.09765751659870148,
-0.018148574978113174,
0.33278051018714905,
0.14370545744895935,
-0.804689884185791,
0.1380920708179474,
-0.006412877235561609,
0.25417497754096985,
-0.4748004674911499,
0.16713228821754456,
0.10694052278995514,
0.09664825350046158,
-0.4723702073097229,
-0.2057875692844391,
0.015348688699305058,
0.29862895607948303,
-0.33401522040367126,
-0.12477410584688187,
-0.06116507202386856,
-0.12679915130138397,
0.36158785223960876,
-0.3062955141067505,
-0.39805200695991516,
0.04254291206598282,
0.36573097109794617,
0.07582338899374008,
-0.22859182953834534,
0.5070337653160095,
0.045700281858444214,
0.1528395712375641,
-0.4809202253818512
] |
6,817,845 |
Randomised trial of clomiphene citrate treatment and vitamin C for male infertility.
|
Abel B J BJ, Carswell G G, Elton R R, Hargreave T B TB, Kyle K K, Orr S S, Rogers A A, Baxby K K, Yates A A
|
British journal of urology . Vol. 54, No. 6, 1982 Dec
|
A prospective randomised trial was carried out to assess the effect of 6 months' treatment with either clomiphene citrate or vitamin C in 179 men complaining of infertile marriage. There was no significant difference in the wife's pregnancy rates between the 2 treatment groups. In order to detect a subgroup that might respond to clomiphene the results were analysed according to pre-treatment FSH and sperm density, with allowance being made for the result of the wife's tests, but still there was no significant difference in treatment response Vitamin C would seem a preferable and cheaper alternative treatment for male infertility.
|
https://pubmed.ncbi.nlm.nih.gov/6817845/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6817845
|
[
-1.10396409034729,
1.3993232250213623,
-2.9960620403289795,
-1.2832837104797363,
0.14823627471923828,
-0.6504004001617432,
0.5396736264228821,
-0.8063201904296875,
-0.5195475816726685,
0.25763338804244995,
0.36374160647392273,
1.7047456502914429,
0.629612922668457,
-0.4368007183074951,
-0.11473364382982254,
-0.5115428566932678,
-0.7368886470794678,
0.8427394032478333,
1.0149956941604614,
-1.800232172012329,
0.6214080452919006,
0.08149656653404236,
0.3055354952812195,
0.035598453134298325,
0.2813994884490967,
-0.9201791286468506,
-0.47978106141090393,
1.0712379217147827,
-0.3416351079940796,
0.3316061496734619,
-0.07777466624975204,
-0.6408389806747437,
-0.40846124291419983,
-0.3722091615200043,
-0.8572190999984741,
0.07445599138736725,
1.7119091749191284,
0.0981413796544075,
0.06130480766296387,
0.30383870005607605,
0.5636075735092163,
0.1925281435251236,
0.015021733939647675,
-0.0017073937924578786,
1.8265026807785034,
-0.18591170012950897,
-0.09819908440113068,
-1.007179617881775,
-0.5037997364997864,
1.155163288116455,
-0.8094000816345215,
0.5278509259223938,
-0.9024356603622437,
0.12518355250358582,
1.2380809783935547,
0.5011579394340515,
-0.09589523822069168,
0.2743985950946808,
1.2164932489395142,
0.17936964333057404,
0.7560511231422424,
0.08661067485809326,
-0.9049389362335205,
0.22302335500717163,
-0.8084356188774109,
0.22624345123767853,
0.45452243089675903,
-0.5186489224433899,
-0.6871953010559082,
1.0315535068511963,
0.1541403830051422,
-0.42619624733924866,
0.8192365765571594,
-0.01830458454787731,
0.9533513784408569,
0.14297273755073547,
-0.12674030661582947,
0.09112249314785004,
0.5500226020812988,
0.033298809081315994,
-0.8492327928543091,
-0.15444570779800415,
-0.20902730524539948,
0.13436655700206757,
-0.23584869503974915,
0.29687899351119995,
-0.18676552176475525,
-0.5679359436035156,
0.9123761057853699,
-1.3149312734603882,
-0.7071955800056458,
0.5050458312034607,
-0.5312203764915466,
0.1942724734544754,
-0.0024707969278097153,
0.8953430652618408,
-0.3104165196418762,
-0.04382913559675217,
-0.18011793494224548,
0.296603262424469,
0.10297024995088577,
0.11155521869659424,
0.024415556341409683,
0.07875970751047134,
-0.7051345109939575,
-1.0775938034057617,
-0.5201811194419861,
-0.8129234910011292,
-0.23163828253746033,
-0.7426532506942749,
0.3235985338687897,
-0.6492711305618286,
-1.145588994026184,
-0.39003291726112366,
0.48642393946647644,
0.40027499198913574,
-0.4919862449169159,
0.039638079702854156,
-0.06386301666498184,
0.3651188611984253,
0.45658043026924133,
-0.0543985553085804,
0.006914128083735704,
0.01131844986230135,
-0.690768837928772,
0.7468339800834656,
-0.48963072896003723,
0.11138074845075607,
-0.17563340067863464,
-0.533669114112854,
0.03886181861162186,
0.11020882427692413,
0.5531883835792542,
-0.9005886912345886,
-1.765790581703186,
-0.06856393814086914,
0.19600842893123627,
1.955384373664856,
0.04551686346530914,
-0.8900681138038635,
-0.2799287438392639,
-0.14676491916179657,
0.43032389879226685,
0.41685307025909424,
-1.0976297855377197,
-0.8678770065307617,
0.13556312024593353,
0.11560089141130447,
-0.5257651209831238,
-0.3343324363231659,
-0.4297235310077667,
1.1306599378585815,
0.83052659034729,
0.18109440803527832,
-0.6394668817520142,
0.8246010541915894,
-0.1459685117006302,
0.05341508984565735,
0.21509647369384766,
-0.2962527275085449,
0.7041146159172058,
-1.1377242803573608,
-0.44346415996551514,
-0.12036018818616867,
0.0895504355430603,
0.5573422312736511,
-0.0334947295486927,
-0.024854179471731186,
0.19389653205871582,
-0.04090869426727295,
-0.30830371379852295,
-0.0667644515633583,
0.7277213931083679,
0.6207489967346191,
0.10008189082145691,
-0.06257788091897964,
0.502322256565094,
-0.1845199465751648,
-0.22414912283420563,
-0.7962220907211304,
0.4691571593284607,
0.04857615381479263,
0.30678611993789673,
-0.3226720094680786,
-0.43785926699638367,
-0.9619476199150085,
-0.820913553237915,
-0.5546313524246216,
0.6693421602249146,
0.28297555446624756,
-0.016570178791880608,
-0.38964056968688965,
0.2605583667755127,
-0.5441051125526428,
0.3271001875400543,
-0.0803079828619957,
-0.25360631942749023,
0.07946331799030304,
-0.2462889701128006,
-0.04191279411315918,
0.31671610474586487,
0.5412083864212036,
0.10938086360692978,
0.6339936852455139,
0.2355351746082306,
-0.31878411769866943,
-0.17020954191684723,
-0.29864978790283203,
-0.05595738813281059,
0.6868981719017029,
0.1551607996225357,
-0.37572529911994934,
0.03541860356926918,
0.1230149120092392,
0.21187393367290497,
0.7881373763084412,
-0.05365069955587387,
0.9236685633659363,
-0.3152327537536621,
0.18137668073177338,
-0.4909437894821167,
-0.021890684962272644,
0.4575502276420593,
0.199644073843956,
-0.14299911260604858,
0.10069875419139862,
0.48190468549728394,
0.3907375931739807,
0.27005892992019653,
0.18032222986221313,
-0.3095531463623047,
-0.6726264357566833,
-0.08278468996286392,
-0.3107626140117645,
-0.6434099078178406,
-0.2792297601699829,
-0.5788838267326355,
-0.5936868786811829,
-0.5982564687728882,
-0.30210158228874207,
0.5054338574409485,
-0.26819244027137756,
0.3020784556865692,
-0.10417687892913818,
0.06337267905473709,
-0.5941815972328186,
0.06613840907812119,
0.4328264892101288,
0.03186440095305443,
0.04178859293460846,
0.006933929398655891,
0.06914859265089035,
0.2291729599237442,
0.17717783153057098,
0.16555771231651306,
-0.5377947688102722
] |
6,817,944 |
The effect of sodium cromoglycate delivered by Spinhaler and by pressurized aerosol on exercise-induced asthma in children.
|
Bundgaard A A, Bach-Mortensen N N, Schmidt A A
|
Clinical allergy . Vol. 12, No. 6, 1982 Nov
|
Sixteen children completed a randomized placebo-controlled double-blind study comparing the efficacy of pre-treatment with (1) 20 mg sodium cromoglycate (SCG) powder delivered by Spinhaler, (2) 2 mg SCG delivered by pressurized aerosol and (3) placebo. The drug was administered 15 min before the 6 min of treadmill-running performed at the same time of day on 3 consecutive days in a climate chamber with a temperature of 23 degrees C and a relative humidity of 40%. All the patients, none of whom were taking systemic steroids, had shown a post-exercise fall in peak expiratory flow (PEF) of more than 15% from baseline when tested one day prior to the study. On the day with no pre-treatment the average post-exercise fall in PEF was 46% (+/- 4) (mean +/- s.e. mean). After pre-treatment with SCG powder the average fall in PEF was 21% (+/- 3), after pre-treatment with SCG aerosol the fall was 22% (+/- 3) and after placebo a post-exercise fall of 31% (+/- 5) was seen. Both forms of SCG were significantly better than pre-treatment with placebo. Comparing no pre-treatment with pre-treatment with placebo revealed a statistically significant difference (P less than 0 . 001) indicating a placebo effect. It is concluded that this study design has a marked placebo effect. Both pre-treatment with 2 mg SCG delivered by pressurized aerosol and 20 mg delivered by Spinhaler is superior to placebo in conferring protection against exercise-induced asthma (EIA). No bronchodilating effect was seen in the first 15 min after administration of the drug.
|
https://pubmed.ncbi.nlm.nih.gov/6817944/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6817944
|
[
-0.8965357542037964,
1.3971714973449707,
-0.6099047660827637,
-2.2146623134613037,
0.8138843774795532,
1.598318099975586,
1.0034488439559937,
0.1339530199766159,
0.1406049281358719,
-0.7347409129142761,
-0.1695820391178131,
0.6739273071289062,
0.7052643299102783,
0.290437251329422,
-0.33552926778793335,
-0.17829960584640503,
-0.7857258915901184,
0.4209804832935333,
0.9698704481124878,
-1.0425856113433838,
0.45490580797195435,
-0.3744877278804779,
-0.49945715069770813,
0.047555793076753616,
-0.11667775362730026,
-0.5557724833488464,
0.15359358489513397,
0.8211319446563721,
0.2514641582965851,
0.7072590589523315,
0.22310367226600647,
-0.4191749095916748,
0.848138153553009,
-0.8012086749076843,
-0.1745184361934662,
0.764870822429657,
0.1976703256368637,
-0.2680019736289978,
-0.34962061047554016,
0.01246611401438713,
-0.29847803711891174,
0.775368332862854,
0.23356178402900696,
-0.27526190876960754,
1.2173227071762085,
0.6173580288887024,
0.2885321080684662,
0.08212264627218246,
-0.7999000549316406,
-0.38557007908821106,
-0.02799120545387268,
0.4282568693161011,
-0.639721691608429,
-0.05158604308962822,
1.6454440355300903,
-0.3392334282398224,
0.15318846702575684,
0.004234938882291317,
0.7796708941459656,
-0.4461151659488678,
0.44907549023628235,
0.16043592989444733,
0.07131244242191315,
-0.14399677515029907,
0.336146742105484,
-0.6360966563224792,
-0.10104601830244064,
0.5265220403671265,
-0.8960694074630737,
0.46435561776161194,
0.15708546340465546,
-0.21898560225963593,
0.28102996945381165,
0.03146039694547653,
0.46318089962005615,
0.559423565864563,
-0.19873583316802979,
0.28394854068756104,
0.43494975566864014,
0.1584240347146988,
-0.11069615930318832,
0.09198355674743652,
-0.03256536275148392,
0.06444093585014343,
-0.1673407256603241,
0.4700376093387604,
-0.3705015182495117,
0.13192123174667358,
0.4309074878692627,
-0.8697275519371033,
-0.08035501092672348,
-0.5310559868812561,
-0.886160671710968,
0.8435531258583069,
-0.28291022777557373,
0.1964089274406433,
0.2045220583677292,
0.15703022480010986,
0.022731808945536613,
0.29574140906333923,
0.5787653923034668,
0.13997536897659302,
0.35970398783683777,
0.6567263603210449,
-0.9736242294311523,
-0.04127754643559456,
-0.40481096506118774,
-0.32087427377700806,
-0.27205511927604675,
-0.6112805008888245,
-0.13481125235557556,
-0.5090265274047852,
-0.04048188030719757,
-0.2726955711841583,
0.7547674179077148,
0.33268436789512634,
-0.020736850798130035,
0.058216750621795654,
-0.1472892463207245,
-0.17465145885944366,
-0.10355740785598755,
0.7257388234138489,
0.17119774222373962,
0.3636530637741089,
-0.23150166869163513,
0.14973293244838715,
-0.050019267946481705,
0.5640744566917419,
-0.08649346232414246,
-0.5970010161399841,
-0.5201612710952759,
0.6188245415687561,
0.6788583993911743,
0.03719516843557358,
-1.3264528512954712,
-0.5075315833091736,
0.1573590636253357,
0.6416757702827454,
0.052479762583971024,
-0.7386294007301331,
0.11041969805955887,
-0.019524283707141876,
-0.18723468482494354,
-0.3272733986377716,
-0.6936030983924866,
0.05887489393353462,
-0.5558896660804749,
0.22406557202339172,
-0.6748817563056946,
0.2616039514541626,
0.09940119832754135,
0.4596467614173889,
-0.19685137271881104,
-0.15144085884094238,
-0.09409112483263016,
0.16460564732551575,
-0.07344307005405426,
0.596455454826355,
-0.22156700491905212,
-0.21376867592334747,
0.18381181359291077,
-0.23317812383174896,
0.10916797816753387,
-0.004898528102785349,
0.1750558614730835,
-0.14219388365745544,
-0.056763578206300735,
-0.13665646314620972,
0.21535035967826843,
-0.25377362966537476,
-0.5326999425888062,
0.02730170078575611,
0.3572634160518646,
0.47630318999290466,
0.0326150506734848,
0.23264344036579132,
0.04759478196501732,
0.09709938615560532,
0.3697391152381897,
-0.3594758212566376,
0.2644842565059662,
-0.049518849700689316,
0.14247265458106995,
0.02563338354229927,
0.0426020622253418,
-0.6956172585487366,
-0.13545045256614685,
-0.13720041513442993,
0.22743353247642517,
0.4744429886341095,
-0.14512202143669128,
-0.29720285534858704,
0.33690351247787476,
-0.040201399475336075,
0.22986093163490295,
-0.20940367877483368,
-0.2582801580429077,
0.004884542431682348,
0.417044073343277,
0.15001192688941956,
0.19374242424964905,
0.300481379032135,
-0.06414806842803955,
0.7464619278907776,
-0.26719918847084045,
-0.2880227565765381,
-0.18304041028022766,
0.14864462614059448,
-0.2601918578147888,
0.49691927433013916,
0.1821293979883194,
0.04428594186902046,
-0.07282879203557968,
0.3476293981075287,
0.30008330941200256,
0.24119389057159424,
-0.08285538852214813,
-0.09914498031139374,
-0.4915798604488373,
0.43978965282440186,
-0.0995466560125351,
0.08154815435409546,
-0.11928729712963104,
0.05877336487174034,
-0.09529010206460953,
-0.3900376856327057,
0.30477192997932434,
0.2495412826538086,
0.08470571786165237,
-0.1573944240808487,
-0.3997620940208435,
0.08986900001764297,
0.09918970614671707,
-0.264794260263443,
0.0754501223564148,
-0.1531941443681717,
0.2109404355287552,
0.22611859440803528,
-0.012623196467757225,
-0.14227275550365448,
-0.045996762812137604,
-0.4616970419883728,
-0.14572139084339142,
0.11216556280851364,
0.3213669955730438,
-0.2891390919685364,
-0.1047416478395462,
0.36203277111053467,
-0.019374743103981018,
-0.1800747811794281,
0.030725635588169098,
-0.31372660398483276,
-0.237534761428833,
0.41369521617889404,
-0.30031654238700867,
-0.2014485001564026
] |
6,818,039 |
Effects of oral chlordemethyldiazepam on plasma adrenaline and noradrenaline and cardiovascular reactivity in preoperative patients.
|
Picotti G B GB, Corli O O, Galva M D MD, Bondiolotti G P GP, Carruba M O MO
|
European journal of clinical pharmacology . Vol. 23, No. 5, 1982
|
In 11 preoperative women, plasma adrenaline (A) concentrations were lower after oral administration of an antianxiety dose (19.25 micrograms/kg) of chlordemethyldiazepam (Cl-DMDZ) than the predrug values, or those in 12 patients given placebo. No significant differences in supine plasma noradrenaline (NA), blood pressure (BP) and heart rate values were observed. Digital plethysmography showed finger vasoconstriction after placebo and vasodilatation after Cl-DMDZ. A mental arithmetic test caused equivalent rises in plasma A in both groups. Standing caused plasma NA to rise to similar levels in both groups of patients, but the BP decrease was less and there was a markedly lower incidence of orthostatic hypotension in the Cl-DMDZ treated group. It is concluded that the effect of Cl-DMDZ on the release of catecholamines from the peripheral sympathetic system consists essentially of decreasing basal adrenomedullary activity. CL-DMDZ appears to prevent the orthostatic hypotension which occurs when neurosympathetic reflex activation is normal.
|
https://pubmed.ncbi.nlm.nih.gov/6818039/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6818039
|
[
0.062302280217409134,
-0.1938454806804657,
-2.6954238414764404,
-2.4766900539398193,
0.9931847453117371,
-0.14598768949508667,
0.8528055548667908,
1.024922251701355,
-1.5336902141571045,
0.33140361309051514,
0.4526289999485016,
1.1435401439666748,
-0.4911929965019226,
-0.1398925483226776,
-0.12100419402122498,
0.0355401486158371,
-0.11776390671730042,
0.9720274209976196,
0.6177674531936646,
-1.9573287963867188,
0.7703176140785217,
-1.0559006929397583,
-0.534909725189209,
-2.174563407897949,
0.4448509216308594,
-1.7370859384536743,
0.9518839120864868,
0.7021006941795349,
0.5974000692367554,
0.6144017577171326,
0.15547607839107513,
0.5764177441596985,
1.6478368043899536,
0.11883655190467834,
0.4460381269454956,
-0.30194029211997986,
0.5958930850028992,
-0.7938035726547241,
0.8800365328788757,
0.0645894706249237,
-0.1762721687555313,
0.6684890985488892,
0.04534802585840225,
-0.20235338807106018,
0.2627820074558258,
1.50131356716156,
0.3316323757171631,
0.24546802043914795,
0.7938936352729797,
-0.7174618244171143,
-1.2089970111846924,
0.5253050327301025,
-1.2130482196807861,
-0.5210219025611877,
2.0157458782196045,
0.835521399974823,
0.12046845257282257,
0.5362970232963562,
0.9851029515266418,
-0.5926836133003235,
0.06950435787439346,
0.6952460408210754,
0.2487223595380783,
0.8704674243927002,
-0.6745349168777466,
-0.33406969904899597,
0.13063444197177887,
0.03578028082847595,
-1.0611342191696167,
0.5559703707695007,
-1.0919013023376465,
-0.38668638467788696,
0.5548495054244995,
0.5433551073074341,
0.6481137871742249,
-0.3550952970981598,
-0.4212673008441925,
1.0340863466262817,
1.0353449583053589,
0.14885357022285461,
-1.1125507354736328,
0.14352375268936157,
-1.2270286083221436,
0.25190094113349915,
0.2936093807220459,
0.20005568861961365,
-0.588201105594635,
-0.5087860226631165,
0.8524437546730042,
-0.4912927448749542,
-0.4889470934867859,
-0.589946448802948,
-1.1535582542419434,
0.014364016242325306,
0.02440725639462471,
-0.0031683039851486683,
-0.2687986195087433,
0.6152019500732422,
-0.9302254915237427,
0.3893050253391266,
0.6925005316734314,
0.008184793405234814,
-0.35508525371551514,
0.3814932107925415,
-0.34482133388519287,
-0.49250882863998413,
-0.05467194691300392,
-1.2748860120773315,
-0.5980196595191956,
-0.3594067692756653,
0.18731330335140228,
0.3151056170463562,
0.02380150929093361,
-0.1363907754421234,
0.3317964971065521,
1.1281344890594482,
-0.0023480879608541727,
0.11624769121408463,
0.3041228652000427,
-0.4285622835159302,
0.15944033861160278,
1.2201755046844482,
-0.21952742338180542,
0.4766901433467865,
-0.5750206112861633,
0.012614049948751926,
-0.2566738724708557,
-0.1259755939245224,
0.2518555819988251,
-0.27509477734565735,
-0.04956332966685295,
0.8300838470458984,
0.017130527645349503,
-0.323978990316391,
-1.3403584957122803,
-0.05075506120920181,
0.34435147047042847,
0.8679416179656982,
-0.01909618452191353,
-0.368771493434906,
0.030550897121429443,
0.46835771203041077,
-0.34547001123428345,
0.04539314657449722,
-0.8133041262626648,
-0.5170050263404846,
-0.15276017785072327,
0.5797333717346191,
-0.5292112231254578,
0.2379712164402008,
0.2544715106487274,
0.3568934500217438,
0.3925914168357849,
-0.10819141566753387,
-0.10282591730356216,
-0.029594488441944122,
-0.07095371186733246,
0.44796717166900635,
0.38265085220336914,
-0.31586021184921265,
-0.17472337186336517,
-0.4595496654510498,
-0.1925334930419922,
-0.4075816571712494,
0.41208699345588684,
-0.09063288569450378,
-0.11341284215450287,
-0.7287930846214294,
0.36901533603668213,
-0.3406708240509033,
-0.28813955187797546,
0.5478346347808838,
-0.03442859277129173,
0.4490305185317993,
-0.45092231035232544,
0.18486984074115753,
0.193790465593338,
0.38235053420066833,
-0.1292719841003418,
0.013751075603067875,
-0.2159891128540039,
0.348448246717453,
0.17943018674850464,
-0.2979893684387207,
0.08589044213294983,
-0.314266562461853,
-0.3230036497116089,
-0.45004305243492126,
-0.30791258811950684,
0.2780866324901581,
0.058829449117183685,
-0.09528160840272903,
0.05708780512213707,
-0.06859803944826126,
0.24305525422096252,
0.07875824719667435,
-0.22705848515033722,
0.1978570967912674,
0.5184186100959778,
0.009051667526364326,
0.29324468970298767,
0.2690557837486267,
-0.31089338660240173,
0.5319124460220337,
-0.21183986961841583,
-0.030998962000012398,
0.07492239028215408,
-0.08785244077444077,
-0.49427682161331177,
-0.05154760926961899,
-0.22944201529026031,
-0.13272082805633545,
0.4030393064022064,
0.3404929041862488,
0.2769872546195984,
0.23363269865512848,
0.10221857577562332,
0.0794105976819992,
-0.08345404267311096,
0.08972708135843277,
0.22783948481082916,
-0.4073317050933838,
-0.028799166902899742,
0.1000986099243164,
-0.36536648869514465,
0.03493741154670715,
0.08726619929075241,
0.0978635922074318,
-0.01252734288573265,
0.5484246015548706,
-0.33125898241996765,
-0.35772085189819336,
-0.06825853884220123,
-0.43582504987716675,
-0.0060280305333435535,
-0.28643810749053955,
0.21782360970973969,
0.05593499541282654,
-0.044629454612731934,
0.07726254314184189,
0.10667208582162857,
-0.20943205058574677,
-0.1287260502576828,
0.1912250518798828,
0.22209607064723969,
0.10196921974420547,
-0.22704732418060303,
-0.17150601744651794,
-0.06005489453673363,
-0.3224703371524811,
-0.08131201565265656,
-0.050835736095905304,
-0.0013963489327579737,
0.1050775945186615,
0.05205387994647026,
0.20209857821464539
] |
6,818,164 |
Evaluation of FCB, BDP, and DSCG in allergen inhalation challenge test.
|
Wüthrich B B, Chen-Walden H H
|
International journal of clinical pharmacology, therapy, and toxicology . Vol. 20, No. 12, 1982 Dec
|
The protective effect of a new inhaled steroid, fluocortin butyl (FCB), was compared to that of disodium cromoglycate (DSCG) and beclomethasone dipropionate (BDP) in patients with extrinsic asthma by means of the allergen-inhalation challenge test. Three different groups of 12 patients each participated in the study. One group was treated with FCB and BDP, the two others with FCB and DSCG, all in a randomized crossover study plan. After an initial allergen challenge (FEV1 fall greater than 15%), the patients were allocated to either treatment for 7-10 days. A second challenge test was then carried out, followed by a washout period of 4 days. The treatments were then crossed-over, and a third allergen challenge was carried out at the end of the second treatment period. With BDP 5 of 12 patients were protected; with FCB, 6 of 12 in two groups and 8 of 12 patients in a third group. With DSCG 3 of 12 patients were protected in the group in which the last medication was given 12 h before challenge, and 8 of 12 patients in the second group in which medication was given 1-2 h before challenge. In the same groups on FCB no such time-dependent effect was observed. No statistically significant differences were found between either FCB and BDP, or FCB and DSCG in either group.
|
https://pubmed.ncbi.nlm.nih.gov/6818164/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6818164
|
[
0.26695138216018677,
1.6271336078643799,
-0.9276328682899475,
-1.7224838733673096,
1.9126064777374268,
0.6905259490013123,
0.40467947721481323,
0.4527061879634857,
0.2457556128501892,
0.296204537153244,
0.1543412208557129,
1.4893521070480347,
-0.03053746558725834,
0.035177506506443024,
-0.1319894939661026,
-0.30782490968704224,
-0.6861859560012817,
-0.4039038419723511,
1.0999505519866943,
-1.000793218612671,
-0.051115378737449646,
0.7074675559997559,
-0.32377177476882935,
-0.6004500985145569,
-0.08401914685964584,
-0.8638909459114075,
-0.22305569052696228,
0.6432681083679199,
-0.2888684570789337,
0.9098728895187378,
-0.09820269793272018,
-0.24613603949546814,
0.9236405491828918,
-0.7740980386734009,
0.36250293254852295,
0.13435246050357819,
0.6096743941307068,
-0.6436025500297546,
0.10627397149801254,
0.19801150262355804,
0.005458857398480177,
0.7104234099388123,
0.013837847858667374,
-0.7395380735397339,
0.3133366107940674,
-0.1309645026922226,
0.7898175716400146,
0.19246594607830048,
-0.7544789910316467,
0.03984583169221878,
-0.10129078477621078,
0.5618699789047241,
0.028702007606625557,
0.34563732147216797,
0.7813626527786255,
0.10649921745061874,
-0.04387372359633446,
0.9472343325614929,
0.8916382193565369,
-0.0058826967142522335,
0.3830426335334778,
0.45259153842926025,
0.26795336604118347,
-0.5735844969749451,
-0.14289677143096924,
-0.8465582132339478,
-0.15316396951675415,
-0.2150888890028,
-0.8473814129829407,
0.5830087065696716,
-0.3502729833126068,
-0.03263998404145241,
0.6196841597557068,
0.4309023916721344,
0.375261127948761,
0.5990929007530212,
-0.2220815122127533,
0.7052118182182312,
0.3684057891368866,
0.35045844316482544,
0.09584227204322815,
0.11603530496358871,
-0.38470035791397095,
0.1864602118730545,
-0.06497528403997421,
-0.3466636836528778,
-0.9407578706741333,
-0.2177245169878006,
0.12418992817401886,
-0.9900854825973511,
1.0365432500839233,
0.4929279685020447,
-0.8958617448806763,
0.7452280521392822,
-0.43078112602233887,
0.2893466353416443,
-0.15452928841114044,
0.14701618254184723,
-0.1507297158241272,
-0.024920783936977386,
0.06848163157701492,
-0.5600370168685913,
0.2560577690601349,
-0.02506009303033352,
-1.1502645015716553,
-0.3596512973308563,
-0.4414803087711334,
-0.5725013613700867,
-0.7728344202041626,
-0.6345998048782349,
0.5025997757911682,
-0.18324992060661316,
0.10621587932109833,
0.49200567603111267,
0.8577443361282349,
0.2879363000392914,
0.9078276753425598,
-0.37964627146720886,
-0.31230732798576355,
-0.37047016620635986,
-0.09906167536973953,
0.39303523302078247,
0.748741626739502,
0.9868564009666443,
-0.22165809571743011,
-0.06080421432852745,
-0.08351441472768784,
0.4390842914581299,
-0.10361699014902115,
-0.306297242641449,
-0.895920991897583,
0.07972370833158493,
-0.19439484179019928,
0.03954954072833061,
-1.4224445819854736,
-0.4130299687385559,
0.2581314146518707,
1.0148744583129883,
-0.17865103483200073,
-0.5727854371070862,
0.1835898905992508,
-0.012122333981096745,
-0.18350203335285187,
0.1807551085948944,
-0.6685763001441956,
-0.029527392238378525,
0.11336751282215118,
0.05305393785238266,
-0.8310738205909729,
0.18930384516716003,
0.01012455951422453,
0.0468386672437191,
-0.1563565731048584,
0.1372874528169632,
-0.2179834544658661,
0.31284359097480774,
0.19143547117710114,
0.09441621601581573,
0.1110629215836525,
0.2444840967655182,
0.232408806681633,
-0.20771364867687225,
0.2676391303539276,
-0.6203598976135254,
0.19911786913871765,
-0.0761970654129982,
-0.19356244802474976,
0.17329435050487518,
0.250672847032547,
0.06030949950218201,
-0.4077701270580292,
0.06835409998893738,
0.5768665075302124,
0.47805479168891907,
0.10188755393028259,
0.1532294601202011,
0.6377283334732056,
0.41427847743034363,
0.2201617807149887,
-0.4456133246421814,
-0.054260581731796265,
-0.320127010345459,
-0.25780269503593445,
-0.07332038134336472,
-0.4729299247264862,
-0.2029143124818802,
-0.09941055625677109,
-0.1167287826538086,
0.15999606251716614,
0.1002519354224205,
0.26650431752204895,
0.15200278162956238,
-0.06219235062599182,
0.3733331561088562,
0.1836443543434143,
-0.47341734170913696,
-0.07259967178106308,
0.5013592839241028,
0.5346139669418335,
-0.07473745942115784,
0.38886910676956177,
-0.0844997987151146,
-0.02291387878358364,
0.35757800936698914,
0.3122355043888092,
-0.33932381868362427,
-0.11230986565351486,
0.053968314081430435,
-0.2867002487182617,
-0.01645416021347046,
0.305306613445282,
-0.33687862753868103,
-0.12246537208557129,
0.03100058250129223,
0.01256832666695118,
0.46051523089408875,
0.1789499819278717,
0.2221473753452301,
-0.21046961843967438,
0.2506977915763855,
0.14040154218673706,
-0.20972250401973724,
0.22300389409065247,
0.12399796396493912,
-0.0813666358590126,
-0.1642543226480484,
-0.2860495448112488,
-0.12302415817975998,
-0.40007254481315613,
0.3334245979785919,
-0.13876886665821075,
-0.16286659240722656,
-0.09510346502065659,
-0.42791619896888733,
0.056479427963495255,
-0.0518210344016552,
-0.01418254617601633,
0.18398912250995636,
0.022741496562957764,
0.2665442228317261,
-0.18553917109966278,
-0.2284618765115738,
0.07663896679878235,
-0.46240779757499695,
-0.005078266840428114,
-0.07035744935274124,
0.08756397664546967,
0.33941543102264404,
-0.0032470545265823603,
0.0220074113458395,
-0.12829269468784332,
-0.46938151121139526,
0.14244458079338074,
0.5682481527328491,
-0.041808467358350754,
-0.17875444889068604
] |
6,818,169 |
An analgesic study with repeated doses of phenazone, phenazone plus dextropropoxyphene, and paracetamol, using a visual analogue scale.
|
Quiding H H, Oikarinen V V, Huitfeldt B B, Koskimo M M, Leikomaa H H, Nyman C C
|
International journal of oral surgery . Vol. 11, No. 5, 1982 Oct
|
A double blind randomized analgesic trial was carried out in patients suffering from pain after removal of an impacted lower wisdom tooth. In a repeated dose regimen, 120 patients received one of three different analgesics: phenazone, phenazone plus dextropropoxyphene, or paracetamol. The assessments of pain were made hourly on a visual analogue scale and the evaluation was carried out according to a method which considers repeated dose intake. The analgesic efficacy of 500 mg phenazone was similar to 500 mg of paracetamol. The pain reduction seemed adequate in most patients and no statistical differences were obtained between the treatment drugs. All analgesics were taken when needed, and the time interval from end of operation to first tablet intake, as well as the pain score at first tablet intake, were factors which significantly influenced the efficacy of the drugs. Therefore, these factors may be of significant importance in the evaluation of analgesics in small sample studies.
|
https://pubmed.ncbi.nlm.nih.gov/6818169/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6818169
|
[
0.16213512420654297,
1.221612572669983,
-2.1930179595947266,
-2.2270452976226807,
-0.2113950550556183,
-0.751777708530426,
1.9698143005371094,
-1.0193750858306885,
-1.0514308214187622,
-0.7505507469177246,
0.5811061263084412,
2.403123378753662,
0.30513715744018555,
0.5842357873916626,
0.04931497573852539,
0.28301820158958435,
0.34738633036613464,
-0.16377240419387817,
0.2506070137023926,
-2.1836795806884766,
0.012658295221626759,
0.13680382072925568,
-0.790244996547699,
0.5253689289093018,
0.04025827348232269,
-0.6820577383041382,
0.242996945977211,
2.6883974075317383,
0.25553107261657715,
2.65669322013855,
0.39535441994667053,
-1.310238003730774,
0.4119356870651245,
0.321902871131897,
-0.7446120381355286,
-0.19691133499145508,
1.428816318511963,
0.9640839099884033,
-1.4473085403442383,
-0.42553433775901794,
1.2626190185546875,
1.052919864654541,
0.23442277312278748,
-0.20902186632156372,
2.4466910362243652,
0.5046881437301636,
-0.38976556062698364,
0.6019890308380127,
0.7659664154052734,
0.5504254102706909,
0.4928448796272278,
0.53617262840271,
-0.723768413066864,
0.7547326683998108,
1.829775333404541,
-0.20760121941566467,
1.1811796426773071,
0.3239938020706177,
1.6683157682418823,
-0.5843055844306946,
-0.3579067289829254,
0.13277071714401245,
-0.08715134859085083,
0.3776291608810425,
0.6254401206970215,
-0.14400692284107208,
0.39034897089004517,
0.6109622120857239,
-0.05656452104449272,
0.8053438663482666,
-0.9139739871025085,
0.13106954097747803,
0.3683377802371979,
0.3927289843559265,
1.3119479417800903,
-0.4451195001602173,
0.07319651544094086,
0.8331704139709473,
0.7888695597648621,
1.1758031845092773,
0.08732864260673523,
-0.4333738684654236,
0.13033175468444824,
0.7347571849822998,
-0.31963616609573364,
0.7648157477378845,
-0.35848304629325867,
0.5184524059295654,
0.3672716021537781,
-0.695800244808197,
0.3845682442188263,
-0.4102296531200409,
-1.5421340465545654,
-0.01798916421830654,
-1.1506831645965576,
0.7134105563163757,
-0.6182898879051208,
-0.4474835693836212,
-1.0632600784301758,
0.26535674929618835,
0.3610774874687195,
0.2156423032283783,
-0.5563602447509766,
0.27266961336135864,
-0.9884888529777527,
0.11279227584600449,
-0.3658430576324463,
-0.14346270263195038,
-0.07691214233636856,
-1.0276392698287964,
0.7439165711402893,
-0.5158828496932983,
-0.1430131196975708,
-0.3098275661468506,
0.36126354336738586,
0.8669273257255554,
-0.0305641982704401,
0.28860577940940857,
0.3593534529209137,
0.1537044495344162,
1.1109477281570435,
0.24677400290966034,
-0.2527620792388916,
1.002022624015808,
-0.4244922697544098,
0.1633632630109787,
0.43326008319854736,
0.15464811027050018,
-0.6841684579849243,
-0.5165181159973145,
-0.9832199811935425,
0.30023446679115295,
-0.08707427233457565,
-0.5579831004142761,
-0.737057089805603,
-0.9083771705627441,
0.5186590552330017,
1.421986699104309,
-0.18049639463424683,
-1.1556813716888428,
-0.47661933302879333,
0.35794371366500854,
-0.18218538165092468,
0.0904640406370163,
-0.8467488288879395,
-0.29671740531921387,
-0.2145613133907318,
-0.16942846775054932,
-0.5622909069061279,
-0.1997709721326828,
-0.5522780418395996,
0.8122019171714783,
0.19962365925312042,
-0.42326945066452026,
-0.1144339069724083,
-0.10869363695383072,
0.4315904676914215,
0.6317710280418396,
0.6900495886802673,
-0.15035448968410492,
0.3453105688095093,
-0.8769587874412537,
0.24172218143939972,
-0.48474857211112976,
-0.1060144454240799,
0.10536778718233109,
-0.23239833116531372,
-0.012816268019378185,
0.3987140953540802,
0.034227095544338226,
-0.9710333347320557,
0.377370685338974,
0.135486900806427,
0.6532524228096008,
-0.3188779354095459,
-0.09504679590463638,
0.5231339931488037,
0.19292427599430084,
0.7197118401527405,
-0.147585928440094,
-0.4851098954677582,
-0.3373057544231415,
0.1376073956489563,
-0.4662538170814514,
-0.22012268006801605,
-0.471825510263443,
-0.10439357906579971,
-0.4926966428756714,
-0.04680703207850456,
0.3726663291454315,
0.4292789399623871,
-0.607506275177002,
-0.03489888831973076,
0.12876161932945251,
0.07061644643545151,
-0.0069920653477311134,
-0.5234538316726685,
-0.151153102517128,
0.30462023615837097,
-0.3836301565170288,
0.29707133769989014,
0.3789325952529907,
-0.09856396913528442,
0.6685503125190735,
-0.12831781804561615,
-0.3013402223587036,
-0.3940056264400482,
0.4134446978569031,
-0.6260722875595093,
0.17151355743408203,
0.1059640571475029,
-0.4967120885848999,
-0.03750278800725937,
0.3480316400527954,
-0.28459274768829346,
0.14938384294509888,
0.07032719254493713,
0.5717654824256897,
-0.0688781663775444,
-0.2481212466955185,
-0.010046483017504215,
-0.15928630530834198,
-0.14768609404563904,
0.43655917048454285,
-0.6968189477920532,
-0.25172242522239685,
0.05380699038505554,
0.29364559054374695,
-0.6236582398414612,
0.12873998284339905,
-0.16089597344398499,
0.24610164761543274,
-0.19519974291324615,
0.0687282383441925,
0.19421468675136566,
0.18298660218715668,
0.2750435173511505,
0.18979887664318085,
-0.45267176628112793,
0.2743794023990631,
-0.1074800044298172,
-0.22246654331684113,
-0.27725401520729065,
-0.052774205803871155,
0.08039937168359756,
-0.36434635519981384,
-0.07719720900058746,
0.6986136436462402,
0.02629462070763111,
0.1255931556224823,
-0.11382116377353668,
-0.29756325483322144,
0.021705450490117073,
0.46037963032722473,
-0.20325225591659546,
-0.2965465486049652
] |
6,818,195 |
Preliminary results of a phase III trial of spontaneous animal tumors to heat and/or radiation: early normal tissue response and tumor volume influence on initial response.
|
Dewhirst M W MW, Connor W G WG, Sim D A DA
|
International journal of radiation oncology, biology, physics . Vol. 8, No. 11, 1982 Nov
|
A Phase III randomized trial was initiated to test the relative efficacies of heat alone, radiation alone and heat plus radiation using spontaneous malignancies in pet animals. Heat alone was inferior to the other two treatment arms as demonstrated by a significantly higher non-response rate and shorter response duration. The ratio of complete response rates (CR) for heat plus radiation to radiation alone or the thermal relative risk (TRR) was greater for tumors greater than 10 cm3 as compared to those less than 10 cm3 (TRR = 4.8 and 1.4, respectively). The overall TRR for complete responses was 2.3. The CR data for the combined therapy arm indicate at least an additive effect between heat and radiation for small tumors but most likely a synergistic effect in the larger tumor group. Based on the data currently available, no significant difference in response duration is observed between the two radiation arms, although a nonsignificant advantage to the combination therapy exists. Normal tissue effects were evaluated by incidence of full moist desquamation within the irradiated volume, late fibrosis and bone necrosis. Since the radiation skin dose depended upon the technique being used it was possible to estimate the dose to achieve moist desquamation in 50% of the animals (DD50) by a logistic regression model as being 3728 +/- 344 rad for radiation alone. Significant lowering of the DD50 was not observed for the addition of heat to radiation. Low patient numbers where intact skin was heated prevented an accurate analysis of the effect, however.
|
https://pubmed.ncbi.nlm.nih.gov/6818195/
|
[
"Clinical Trial",
"Journal Article",
"Research Support, U.S. Gov't, P.H.S."
] |
6818195
|
[
-0.6603940725326538,
1.6763477325439453,
-1.7406384944915771,
-2.034217357635498,
0.3466070890426636,
0.533646285533905,
0.3808521628379822,
-1.1799664497375488,
-1.2950156927108765,
0.03972819820046425,
0.11994068324565887,
2.2056384086608887,
-0.8048912882804871,
-0.6240807175636292,
-1.0520366430282593,
0.9775328636169434,
-0.6833227872848511,
0.7775612473487854,
0.22587363421916962,
-1.9619579315185547,
-0.8769012689590454,
-0.24744395911693573,
0.516166627407074,
1.2354848384857178,
0.14250092208385468,
-0.7114084959030151,
-0.5088188648223877,
0.888748288154602,
0.49026188254356384,
0.30013391375541687,
-0.57414710521698,
0.2748866677284241,
0.46601930260658264,
1.0811134576797485,
0.5272208452224731,
0.39176490902900696,
1.593703269958496,
0.03086361289024353,
-0.3368909955024719,
0.18465140461921692,
0.39328959584236145,
-0.1647004783153534,
0.05631912872195244,
-0.7841520309448242,
1.0539538860321045,
-0.2942280173301697,
-0.4754050374031067,
-0.8833959698677063,
-0.269477516412735,
-0.8994423151016235,
-0.8349310755729675,
0.5288689136505127,
-0.5827260613441467,
0.06450386345386505,
1.9438568353652954,
0.17328137159347534,
0.41253185272216797,
-0.19185204803943634,
0.7128202319145203,
-0.18410684168338776,
0.6223822832107544,
0.5366782546043396,
-0.01741926558315754,
-0.24949797987937927,
0.25913792848587036,
-1.2034908533096313,
0.19454392790794373,
-0.4207358956336975,
-0.9099844098091125,
0.4806062579154968,
0.2597234845161438,
0.579397976398468,
0.37499672174453735,
0.13453981280326843,
0.8263447880744934,
0.1875915676355362,
-0.38056761026382446,
0.4241815209388733,
0.10302094370126724,
0.27296411991119385,
-0.8875872492790222,
-1.0986324548721313,
-0.38903120160102844,
0.5070856809616089,
0.6759532690048218,
-0.1559348851442337,
-0.4226366877555847,
-0.5156513452529907,
0.36422017216682434,
-0.5723937749862671,
-0.12578314542770386,
-0.3167051374912262,
-1.4544559717178345,
0.14742305874824524,
-0.491108238697052,
0.3483418822288513,
0.0553898811340332,
-0.4602748453617096,
-0.4079607129096985,
-0.22842144966125488,
0.5560285449028015,
0.6880579590797424,
-0.2917720377445221,
0.26923877000808716,
-0.17663443088531494,
-1.2779767513275146,
-0.28416508436203003,
-0.5612573027610779,
-0.4008854031562805,
-0.632627010345459,
0.7419309020042419,
-1.0519590377807617,
0.31058019399642944,
-1.1465144157409668,
0.6047700643539429,
0.617610514163971,
0.4687364995479584,
0.23362836241722107,
-0.008598997257649899,
-0.949691891670227,
0.3042526841163635,
0.24105234444141388,
0.16542717814445496,
0.9839259386062622,
-0.19357727468013763,
-0.13285192847251892,
0.16170476377010345,
0.543709933757782,
-0.7472299337387085,
-0.5694838166236877,
-0.5049217343330383,
0.2642642855644226,
0.04333988577127457,
-0.7544102072715759,
-0.5070174932479858,
-0.11298497021198273,
0.027708103880286217,
0.6245607137680054,
0.7938138246536255,
-0.31992051005363464,
0.13047295808792114,
0.19242164492607117,
0.20957401394844055,
0.1214214414358139,
-0.5740976929664612,
-0.2839142382144928,
-0.13940151035785675,
0.6804643869400024,
-0.3957289457321167,
-0.03950692340731621,
-0.3281973600387573,
0.2755137085914612,
-0.1260829120874405,
0.3289889991283417,
-0.36338990926742554,
0.023324593901634216,
0.5360868573188782,
-0.18946421146392822,
0.17498958110809326,
-0.38238126039505005,
0.5537832379341125,
-0.0017323860665783286,
0.08520890027284622,
-0.5431554913520813,
0.6247340440750122,
-0.20514123141765594,
-0.17510895431041718,
-0.31039246916770935,
0.04807237535715103,
0.10512389242649078,
-0.38087812066078186,
0.02841237746179104,
0.24112287163734436,
0.56685471534729,
0.26634007692337036,
0.38255366683006287,
0.4865734577178955,
-0.3210781216621399,
0.26957187056541443,
-0.33717629313468933,
-0.0756949782371521,
0.03289968520402908,
0.16260403394699097,
-0.029345009475946426,
0.007503843400627375,
-0.3271762430667877,
0.005736644379794598,
-0.33131012320518494,
0.0663396567106247,
0.2687538266181946,
0.3446953594684601,
0.084664486348629,
0.22749876976013184,
0.37502622604370117,
-0.1982417106628418,
0.2624909281730652,
-0.5726817846298218,
0.3547936975955963,
0.08464514464139938,
-0.002227339195087552,
0.03919385001063347,
0.11937258392572403,
0.06726966053247452,
0.39199942350387573,
0.1332964301109314,
-0.27289992570877075,
-0.3356964588165283,
-0.0840233862400055,
-0.5506321787834167,
0.15382781624794006,
-0.021182918921113014,
0.5331069827079773,
0.19174721837043762,
0.027614116668701172,
-0.2161894142627716,
-0.19216367602348328,
0.11586155742406845,
0.07716391980648041,
-0.7439677119255066,
0.03910792991518974,
0.1441609114408493,
0.1895737498998642,
-0.1175759807229042,
0.05071062967181206,
0.19053584337234497,
-0.031363245099782944,
0.39640891551971436,
0.021736744791269302,
0.5210472345352173,
-0.188943549990654,
-0.16370277106761932,
-0.09085313975811005,
0.04908780753612518,
-0.07029185444116592,
-0.18740203976631165,
-0.2506534159183502,
0.12873291969299316,
0.13182367384433746,
-0.14318229258060455,
-0.0555579774081707,
0.2189900428056717,
-0.44699543714523315,
-0.6059166193008423,
-0.2009405791759491,
0.3482218384742737,
-0.37195539474487305,
0.15738414227962494,
-0.0016225787112489343,
-0.16433124244213104,
-0.3947361707687378,
0.0774756520986557,
0.2306787073612213,
0.14746856689453125,
0.6423993706703186,
-0.06430430710315704,
-0.07610846310853958
] |
6,818,581 |
Effect of caffeine on performances of a perceptual-restructuring task at different stages of practice.
|
Broverman D M DM, Casagrande E E
|
Psychopharmacology . Vol. 78, No. 3, 1982
|
Caffeine, a sympathomimetic drug which stimulates the adrenergic nervous system, was hypothesized to exert opposite effects upon performances of a perceptual-restructuring task (the Embedded Figures Task) at different stages of practice. Specifically, caffeine was hypothesized to impair performances of perceptual-restructuring tasks when the task is still novel in early trials; and to facilitate practice induced gains in task performance as the task becomes less novel. Sixty male undergraduates were studied. Each subject was tested on the Embedded Figures Task twice, in one of the following three sequences: caffeine-placebo; placebo-caffeine; and placebo-placebo. Both hypotheses received statistically significant support.
|
https://pubmed.ncbi.nlm.nih.gov/6818581/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6818581
|
[
-1.2038158178329468,
1.4154058694839478,
-3.1535463333129883,
-2.994202136993408,
0.3061143457889557,
0.0883014053106308,
0.09568557143211365,
0.1506079137325287,
-1.128118872642517,
0.8193506598472595,
1.44950532913208,
0.8015919923782349,
-0.017037073150277138,
0.5631909966468811,
0.6710238456726074,
0.06961217522621155,
-0.5881149768829346,
-0.6700285077095032,
1.0200259685516357,
-1.701434850692749,
-0.456080824136734,
-0.6048337817192078,
-1.8212270736694336,
-1.0553081035614014,
0.8122252225875854,
0.40747693181037903,
-0.6272571086883545,
1.7318224906921387,
-0.1682465523481369,
1.4089429378509521,
0.0580420084297657,
0.2271035611629486,
0.9742209315299988,
-0.32287687063217163,
-0.7400026321411133,
0.2394665777683258,
0.2345176488161087,
1.4615243673324585,
-1.2730848789215088,
-0.150144562125206,
0.4705997705459595,
1.4538530111312866,
0.536311149597168,
0.7821083068847656,
0.7495304346084595,
0.37677207589149475,
0.5018634796142578,
0.011305267922580242,
-1.2157007455825806,
-0.4419459402561188,
-0.27897757291793823,
0.10828661173582077,
-0.6058688163757324,
-0.6645357012748718,
1.248651146888733,
-0.5859772562980652,
-0.5753041505813599,
-0.0807323083281517,
0.3774983584880829,
-0.757757306098938,
0.6518952250480652,
-0.4056382179260254,
0.08865892142057419,
0.6811032891273499,
-0.05826128274202347,
-0.8965616226196289,
0.5643333196640015,
-0.1519981324672699,
-1.8046115636825562,
-0.22676372528076172,
1.1859784126281738,
0.14236585795879364,
0.5304452180862427,
0.18875569105148315,
0.9136751890182495,
0.8118576407432556,
-1.1061756610870361,
0.20237760245800018,
1.6547613143920898,
0.6679965853691101,
0.4803425967693329,
0.6123988628387451,
-0.4924701452255249,
-0.33364012837409973,
-0.27306437492370605,
-0.5944467782974243,
-0.5303938984870911,
-0.4567681849002838,
0.42481330037117004,
0.158542662858963,
-0.6452195644378662,
0.5864865183830261,
-1.0391126871109009,
-0.2765534222126007,
0.42430105805397034,
-1.1501840353012085,
-0.309162974357605,
0.31878942251205444,
-0.7554665803909302,
0.20513319969177246,
0.08503935486078262,
0.2303156703710556,
0.4340977668762207,
0.5955746173858643,
-0.5482916831970215,
-0.11615276336669922,
0.8119398951530457,
-1.8009980916976929,
-0.4825158417224884,
-0.004458494018763304,
0.14710155129432678,
0.12565138936042786,
0.508283793926239,
-0.5072256326675415,
0.6379668712615967,
0.9032648801803589,
0.1856069266796112,
0.026869991794228554,
-0.005546920467168093,
-0.6521214842796326,
0.4902516007423401,
1.3716062307357788,
0.27246788144111633,
0.12097325921058655,
-0.36976438760757446,
0.43461599946022034,
-0.14981000125408173,
-0.40162813663482666,
-0.6307336091995239,
-0.249041348695755,
-1.1956188678741455,
-0.25933513045310974,
-0.10576584190130234,
-0.7973111867904663,
-0.9539940357208252,
-1.9385852813720703,
0.031408604234457016,
0.580350935459137,
-0.0414968803524971,
-0.04932444170117378,
-0.5111606121063232,
0.845758855342865,
0.3591824173927307,
-0.568506121635437,
-0.12585653364658356,
-0.1771842986345291,
0.08558282256126404,
0.007756997365504503,
0.3296579122543335,
0.19329354166984558,
-0.3525562882423401,
0.42538943886756897,
0.15295086801052094,
0.10622642189264297,
-0.2694663405418396,
-0.4799690842628479,
0.10323157906532288,
0.000936974014621228,
0.35395053029060364,
0.026252901181578636,
-0.7461724877357483,
-0.6218476295471191,
0.24913376569747925,
-0.4234023690223694,
-0.15491656959056854,
-0.6571145057678223,
0.462615966796875,
0.17230401933193207,
-0.09971283376216888,
-0.9717490673065186,
-0.6125670671463013,
0.15275995433330536,
-0.17119711637496948,
-0.007594669703394175,
-0.4625360369682312,
-0.2752550542354584,
0.4209955632686615,
0.16467934846878052,
0.2841218411922455,
-0.1193704605102539,
0.2778377830982208,
0.17808543145656586,
-0.005980977322906256,
-0.022095056250691414,
-0.20076921582221985,
0.08498004823923111,
-0.1255396455526352,
-0.34359484910964966,
0.5015809535980225,
0.1214582622051239,
-0.5551097393035889,
-0.11653964221477509,
-0.045949120074510574,
-0.3147445321083069,
0.7844316363334656,
-0.3729538023471832,
0.1444510817527771,
-0.3535720109939575,
0.4556129276752472,
-0.3785434365272522,
0.1670113503932953,
0.5720409750938416,
-0.4952131509780884,
0.13381430506706238,
-0.443351149559021,
0.016152789816260338,
-0.13248220086097717,
0.4948296844959259,
-0.35027605295181274,
0.11151868849992752,
0.11583610624074936,
0.11435635387897491,
-0.21426023542881012,
-0.07273580133914948,
0.44083842635154724,
0.2409820556640625,
-0.27345702052116394,
0.07348424941301346,
0.012218036688864231,
-0.06644988059997559,
-0.14506854116916656,
-0.17825375497341156,
-0.3770286440849304,
-0.24322286248207092,
-0.2844051420688629,
0.2149396687746048,
0.2602326571941376,
0.45295026898384094,
-0.19574074447155,
0.04952215030789375,
-0.3619619905948639,
-0.2533436715602875,
-0.057253725826740265,
-0.22703374922275543,
0.22713690996170044,
-0.227793350815773,
-0.29280170798301697,
0.08500790596008301,
-0.3771132528781891,
0.34032052755355835,
-0.028094395995140076,
-0.21317754685878754,
-0.3455387055873871,
-0.34191402792930603,
0.31267330050468445,
-0.4486418068408966,
-0.3846445679664612,
0.22027736902236938,
0.19682349264621735,
-0.24442702531814575,
0.24506494402885437,
-0.08084487169981003,
-0.3608279228210449,
0.2658473551273346,
0.17788662016391754,
0.4184132516384125
] |
6,818,583 |
State-dependent learning in children receiving methylphenidate.
|
Shea V T VT
|
Psychopharmacology . Vol. 78, No. 3, 1982
|
Methylphenidate state-dependent learning was investigated using a paired-associate learning task of 16 pairs of pictures. Subjects were 15 children for whom methylphenidate was currently being prescribed. Each child was seen for two learning sessions and two testing sessions. Learning took place under placebo and under the child's regular dosage of methylphenidate. During retention testing all combinations of learning drug-state and testing drug-state were observed for each child. Data were analyzed using contrast variables which took into account the repeated-measures nature of the design. The results indicated that there was a trend in the direction of state-dependence in the whole sample. Significant symmetrical state-dependent effects were obtained in those subjects whose original learning was facilitated by methylphenidate.
|
https://pubmed.ncbi.nlm.nih.gov/6818583/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] |
6818583
|
[
-0.1920769214630127,
2.512235641479492,
-2.5625805854797363,
-1.827758550643921,
-0.11113206297159195,
0.5899136066436768,
-0.7475337982177734,
-1.5058461427688599,
-0.3255290389060974,
0.659449577331543,
0.2537383437156677,
2.9782774448394775,
-0.9396470189094543,
1.0981431007385254,
-0.4896354079246521,
-0.5103349685668945,
-0.4295891523361206,
-0.5127654075622559,
0.7461731433868408,
-1.8590549230575562,
-0.3840101957321167,
0.9423665404319763,
-1.0097371339797974,
-0.2071034163236618,
0.1984996646642685,
0.7462087869644165,
-0.6722174286842346,
1.311748743057251,
-0.5663741230964661,
2.2662720680236816,
-0.8233280181884766,
0.8047821521759033,
-0.038971204310655594,
-0.30761003494262695,
0.5924853086471558,
0.3086055517196655,
0.809363067150116,
-0.20570917427539825,
-0.8411673903465271,
1.1738471984863281,
0.030788112431764603,
0.9925675988197327,
0.14915411174297333,
-0.2750248908996582,
0.23873434960842133,
0.8945145010948181,
-0.06207074224948883,
0.8472033143043518,
-0.27991193532943726,
-0.0727062076330185,
0.32852575182914734,
1.220413327217102,
-0.31372666358947754,
-1.3415093421936035,
1.7685707807540894,
-0.46297717094421387,
0.4503919780254364,
0.380187451839447,
1.9550248384475708,
-0.7923499941825867,
-0.623663604259491,
-0.14061397314071655,
0.9166845083236694,
1.1017893552780151,
-0.5745120048522949,
-0.17936384677886963,
0.6955099105834961,
0.6832614541053772,
-1.209904670715332,
-0.26554396748542786,
-0.4724663496017456,
0.6786869168281555,
0.7987613677978516,
1.0024124383926392,
0.6389798521995544,
0.3055810332298279,
-0.5052114129066467,
-0.015636004507541656,
1.0752853155136108,
0.5932127833366394,
0.27961814403533936,
-0.8392019867897034,
0.01423987653106451,
-0.043114688247442245,
0.2641094923019409,
0.2154916226863861,
0.1649690419435501,
-0.11067803204059601,
-0.03548666089773178,
-0.17121011018753052,
-0.5601706504821777,
0.5487409830093384,
-1.0370999574661255,
0.28955861926078796,
-0.8082150816917419,
1.9987927675247192,
-0.33442336320877075,
0.7563064694404602,
0.3563729226589203,
0.2817020118236542,
0.4937276542186737,
0.22150728106498718,
-0.2953062057495117,
-0.014093522913753986,
-1.6272011995315552,
-1.392855167388916,
0.05957600846886635,
0.2504180371761322,
-0.8830521702766418,
0.1739361733198166,
-0.5193727612495422,
-0.21747402846813202,
0.11879032850265503,
0.39601802825927734,
0.49693936109542847,
-0.15759600698947906,
1.1332522630691528,
0.17526033520698547,
-0.4161163866519928,
-0.21781039237976074,
0.6204046010971069,
0.8214679956436157,
-0.21081730723381042,
0.5136178135871887,
-0.31493672728538513,
0.27078452706336975,
0.46527960896492004,
-0.43759119510650635,
-0.6926392912864685,
-0.8415706753730774,
-1.0562819242477417,
-0.009354260750114918,
0.22507810592651367,
-1.3899699449539185,
-1.3894895315170288,
-0.3587357699871063,
0.11468318849802017,
1.622493863105774,
0.2993253469467163,
-0.5937708020210266,
-0.3293694257736206,
0.5660622715950012,
0.30374792218208313,
0.03775685653090477,
-0.5228551626205444,
0.25745633244514465,
0.8456727862358093,
-0.40563708543777466,
-0.0024691459257155657,
0.23530855774879456,
-0.3960910141468048,
-0.2607095539569855,
0.2919800281524658,
-0.7564579248428345,
-0.2848670184612274,
-0.07510896027088165,
0.635189414024353,
0.8594133257865906,
0.4653218388557434,
-0.46057286858558655,
1.0737526416778564,
-0.4478731155395508,
0.07339974492788315,
-0.09136109799146652,
-0.418320894241333,
0.18778321146965027,
0.5512720346450806,
0.6649224162101746,
0.2278774529695511,
0.4313482940196991,
-0.06242978572845459,
0.09002049267292023,
-0.1446320116519928,
0.1568906307220459,
0.054779913276433945,
0.03574734553694725,
-0.46747565269470215,
0.5031824707984924,
0.6196644306182861,
0.08090350776910782,
-0.044469527900218964,
0.11497922241687775,
0.3450506031513214,
-0.1550869196653366,
0.26707497239112854,
-0.22227728366851807,
-0.5709753632545471,
0.02112255059182644,
0.5739965438842773,
-0.059360917657613754,
0.09727417677640915,
-0.10655426979064941,
0.04458899796009064,
0.20233847200870514,
0.8081757426261902,
-0.41863110661506653,
0.35136815905570984,
-0.147247776389122,
0.36744073033332825,
-0.1905791014432907,
-0.2336592972278595,
0.07896864414215088,
-0.06922043114900589,
0.054801180958747864,
0.15084728598594666,
0.00890863686800003,
-0.5645789504051208,
-0.03333708271384239,
-0.3803601562976837,
0.10237041860818863,
0.016032619401812553,
-0.8377296328544617,
-0.466244101524353,
-0.16559194028377533,
0.24387699365615845,
0.28424233198165894,
-0.1565748006105423,
0.11298907548189163,
-0.09177420288324356,
-0.12867608666419983,
-0.20785953104496002,
-0.1229109838604927,
-0.36199888586997986,
0.11369563639163971,
-0.5660055875778198,
-0.024297025054693222,
-0.4500392973423004,
0.004341201391071081,
-0.38671883940696716,
-0.19152331352233887,
-0.11911790817975998,
0.3949115574359894,
-0.2456027716398239,
0.615222692489624,
0.003944638650864363,
0.33559560775756836,
-0.2426241636276245,
0.004003983456641436,
0.1143956109881401,
0.22522996366024017,
0.2900395393371582,
-0.12498501688241959,
-0.3357851207256317,
-0.18513651192188263,
-0.28303539752960205,
-0.21378479897975922,
0.3822273910045624,
0.304473876953125,
0.5935571193695068,
-0.4806120693683624,
0.41875967383384705,
-0.0704517513513565,
-0.0033958503045141697,
0.1839323341846466,
0.4518451392650604,
-0.38999754190444946
] |
6,818,587 |
A depot neuroleptic withdrawal study. Plasma concentration of fluphenazine and flupenthixol and relapse frequency.
|
Wistedt B B, Jørgensen A A, Wiles D D
|
Psychopharmacology . Vol. 78, No. 4, 1982
|
A double-blind withdrawal trial in 41 chronic schizophrenic outpatients was carried out during 6 months. Depot neuroleptics (fluphenazine decanoate or flupenthixol decanoate) were compared with placebo to evaluate clinical and neurological effects during continued therapy and during withdrawal. The drugs were significantly more effective than placebo in preventing relapse and rehospitalization. In the placebo group 62% relapsed compared to 27% in the drug group. There was a weak and nonsignificant tendency to a higher relapse frequency in the flupenthixol group compared to the fluphenazine group. After withdrawal for 6 months, plasma levels for fluphenazine were detectable. Plasma levels for flupenthixol were not detectable after 9 weeks of withdrawal. The differences in the plasma levels may possibly explain the difference in relapse rate between the two depot neuroleptics. Furthermore, it was found that the patients who relapsed during fluphenazine treatment had a significantly lower plasma level of the drug than patients who did not relapse during treatment. The results from this study provide some information on the therapeutic levels of fluphenazine and flupenthixol in schizophrenic patients.
|
https://pubmed.ncbi.nlm.nih.gov/6818587/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6818587
|
[
0.42659279704093933,
0.10537093132734299,
-1.4255270957946777,
-3.2433512210845947,
-0.13273799419403076,
0.42835360765457153,
1.6295112371444702,
-0.10125566273927689,
-1.5275837182998657,
0.00514594279229641,
-0.4669615626335144,
2.156679391860962,
-0.1465233713388443,
1.1170722246170044,
-0.15050974488258362,
-0.08009230345487595,
-1.2074105739593506,
0.19536808133125305,
0.631307065486908,
-2.2574784755706787,
1.7413089275360107,
0.06312466412782669,
-0.6514323353767395,
0.3638532757759094,
0.8775414824485779,
-0.2955475151538849,
-1.5653488636016846,
1.3261444568634033,
-0.022387946024537086,
2.0915541648864746,
0.11669818311929703,
0.055896587669849396,
0.739871084690094,
-0.5980570316314697,
0.4070909321308136,
-0.7603977918624878,
0.3319847285747528,
-0.22976645827293396,
-1.1096736192703247,
-0.3212766647338867,
0.019284721463918686,
0.4144634008407593,
-0.6212892532348633,
-0.10391612350940704,
1.9295204877853394,
1.1513872146606445,
0.08694428205490112,
0.1217997744679451,
0.5813649296760559,
-0.48542726039886475,
-0.8050486445426941,
1.17691969871521,
-0.5187654495239258,
-0.8065283298492432,
1.7795950174331665,
-0.4890667498111725,
0.21743842959403992,
1.220624327659607,
-0.2488505095243454,
0.11449340730905533,
0.9806627035140991,
-0.16007216274738312,
-0.15927255153656006,
0.2396140992641449,
-0.5306809544563293,
0.5319018363952637,
-0.08559652417898178,
0.6330978870391846,
-1.92997407913208,
0.24039219319820404,
-0.723767101764679,
-0.6225557923316956,
0.47670778632164,
0.9571723341941833,
1.1745734214782715,
0.24018096923828125,
-0.4348070025444031,
1.0579286813735962,
0.8943888545036316,
0.5025209784507751,
0.06702090054750443,
0.5116558074951172,
-0.6970210671424866,
-0.3682344853878021,
-0.849729597568512,
-1.182857871055603,
-0.7464802861213684,
-0.6291050314903259,
0.6527462005615234,
-1.1261825561523438,
0.1801653504371643,
-0.2941231429576874,
-1.644290804862976,
0.6451539993286133,
-0.7450245022773743,
-0.18646612763404846,
-0.8391759395599365,
0.3452131450176239,
-0.6572294235229492,
0.40303024649620056,
0.292868047952652,
-0.6111393570899963,
-0.7171875834465027,
-0.5528930425643921,
-0.4114623963832855,
-1.0530011653900146,
-0.45630699396133423,
-1.4251357316970825,
-0.5042096972465515,
-0.8105586171150208,
-0.27294740080833435,
-1.0283921957015991,
0.01611694134771824,
0.25328731536865234,
0.708207368850708,
0.521090567111969,
0.3030511438846588,
0.3871477246284485,
-0.32665514945983887,
-0.4029691219329834,
0.316019743680954,
1.2078336477279663,
-0.1448209583759308,
0.6882727742195129,
0.36084797978401184,
0.3531741201877594,
0.32058146595954895,
-0.3040843904018402,
-0.30945885181427,
-0.5316631197929382,
-0.20680080354213715,
0.3765442967414856,
-0.9750422835350037,
-0.6918715238571167,
-1.3059970140457153,
-0.7438050508499146,
0.1430971324443817,
1.6759744882583618,
0.0027670972049236298,
-1.4294747114181519,
-0.07370078563690186,
0.29733091592788696,
-0.27776098251342773,
0.08717430382966995,
-0.6877630352973938,
-0.540763258934021,
-0.19837221503257751,
0.5183699131011963,
-0.5016374588012695,
-0.17112302780151367,
0.3132823407649994,
0.879921019077301,
0.1952657401561737,
0.1701449304819107,
0.0020364646334201097,
0.6263099312782288,
0.03485904261469841,
-0.11377614736557007,
0.6895814538002014,
-0.03178441524505615,
-0.034730829298496246,
-0.07120747864246368,
0.2791568636894226,
-0.021571632474660873,
-0.13762561976909637,
0.30386438965797424,
0.22419457137584686,
0.5664588212966919,
0.11364717781543732,
-0.33883190155029297,
-0.7267603278160095,
0.22222982347011566,
0.5190711617469788,
0.23050828278064728,
-0.011832494288682938,
-0.1310519576072693,
-0.3026968836784363,
-0.18493159115314484,
0.6800316572189331,
-0.07559201121330261,
0.17381834983825684,
-0.0057981242425739765,
0.14710739254951477,
-0.7859436869621277,
-0.07171834260225296,
0.000698868534527719,
-0.36275970935821533,
-0.3406883776187897,
-0.12728001177310944,
0.0875663310289383,
-0.10127164423465729,
0.3741529583930969,
-0.1288294643163681,
-0.01927122473716736,
0.601238489151001,
-0.07229943573474884,
-0.5216205716133118,
0.5681522488594055,
0.17685997486114502,
0.38502439856529236,
-0.02890161983668804,
0.38193386793136597,
0.2120898962020874,
0.9229278564453125,
0.014379607513546944,
-0.25349515676498413,
-0.4165933430194855,
0.3030870258808136,
-0.5422412753105164,
0.7321263551712036,
0.08092313259840012,
-0.1703207939863205,
0.1302027404308319,
0.06459558755159378,
0.4178519546985626,
0.6844376921653748,
-0.2794169783592224,
0.17278844118118286,
0.08194927871227264,
0.3362002372741699,
0.11256122589111328,
-0.38925182819366455,
0.28408730030059814,
0.07729702442884445,
-0.43408873677253723,
0.193776473402977,
0.4924597144126892,
0.3522931933403015,
-0.306321918964386,
-0.4067371189594269,
0.11060064285993576,
0.04923836886882782,
-0.23225173354148865,
-0.15639594197273254,
0.3846917450428009,
-0.2688753008842468,
-0.06987118721008301,
0.10679543018341064,
0.4499153196811676,
0.14412641525268555,
0.11396946758031845,
-0.2891751825809479,
-0.06933663785457611,
-0.16828584671020508,
-0.7307897210121155,
-0.193791463971138,
-0.03503985330462456,
0.34751978516578674,
0.0036200243048369884,
-0.1652056723833084,
-0.20711377263069153,
-0.1894887238740921,
-0.10651154816150665,
-0.37139615416526794,
-0.28398624062538147,
0.0606103278696537
] |
6,818,588 |
Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers.
|
Wilkins J N JN, Carlson H E HE, Van Vunakis H H, Hill M A MA, Gritz E E, Jarvik M E ME
|
Psychopharmacology . Vol. 78, No. 4, 1982
|
Results of this study indicate that nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Previous studies have not addressed the question of whether the stimulus for smoking-related hormone release is the 'stress' of smoking or a pharmacologic action of nicotine and other tobacco substrates. Nicotine exposure is controlled in this study by allowing each subject to smoke only two 2.0 mg nicotine cigarettes during one experimental session and two 0.2 mg nicotine cigarettes in another session. Plasma levels of cortisol, growth hormone, and prolactin for the higher nicotine session were found to be significantly elevated over those for the low-nicotine session, indicating that nicotine itself plays a predominate role in smoking-induced hormone increases. All hormone levels for the 2.0 mg nicotine session had not returned to baseline 60 min after smoking.
|
https://pubmed.ncbi.nlm.nih.gov/6818588/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, Non-P.H.S.",
"Research Support, U.S. Gov't, P.H.S."
] |
6818588
|
[
0.351468563079834,
-0.2423216998577118,
-1.9258463382720947,
-4.145179748535156,
0.8503784537315369,
-1.5224239826202393,
-0.7410820126533508,
0.10657127946615219,
-0.4626956582069397,
0.041375987231731415,
1.4792269468307495,
0.3142275810241699,
-0.26006758213043213,
0.5387401580810547,
-1.4639045000076294,
-0.19626861810684204,
-1.9502602815628052,
0.8210147023200989,
1.6382960081100464,
-0.7819696068763733,
1.9975398778915405,
-1.7410036325454712,
-1.6264147758483887,
-2.4294238090515137,
-0.24234293401241302,
1.5935207605361938,
-1.8081951141357422,
1.49937105178833,
-0.36309629678726196,
1.4082063436508179,
0.13005860149860382,
-0.8493656516075134,
0.037984441965818405,
-0.767281174659729,
-1.69540274143219,
-1.0420472621917725,
3.37469482421875,
-0.012746905907988548,
0.3592980206012726,
-0.12523846328258514,
0.5494415760040283,
1.3731333017349243,
1.1334171295166016,
-0.6155542731285095,
1.7559340000152588,
0.6883292198181152,
1.1598464250564575,
-1.3837357759475708,
0.04308145493268967,
-1.9079629182815552,
-0.3243078887462616,
2.0852489471435547,
-0.8289991617202759,
0.15454746782779694,
3.648247241973877,
0.03349492326378822,
0.9526492953300476,
-0.03700128197669983,
0.36049380898475647,
-1.5031710863113403,
-0.36281219124794006,
0.03850832208991051,
0.28348156809806824,
0.16396558284759521,
0.1485714167356491,
1.451675295829773,
1.0575922727584839,
0.43578436970710754,
-0.8339197039604187,
-0.5361828207969666,
0.2890884280204773,
-0.23960986733436584,
0.8906199336051941,
0.7159422039985657,
3.115455150604248,
1.5544369220733643,
-0.30873817205429077,
-0.1390955150127411,
0.6880446076393127,
-0.21526627242565155,
-0.6894583702087402,
1.080956220626831,
-0.1709633469581604,
0.6911119818687439,
0.8902364373207092,
0.49007925391197205,
-0.3932696282863617,
-0.6371448636054993,
0.18888141214847565,
-2.4895830154418945,
-0.6135414242744446,
-1.7466846704483032,
-1.602165699005127,
-0.4882599711418152,
-0.2751471996307373,
1.8346598148345947,
-0.5013206005096436,
1.1667243242263794,
-0.2822037637233734,
-1.3737448453903198,
0.998818039894104,
0.22552722692489624,
0.23533955216407776,
-0.48848748207092285,
-0.9604865908622742,
-0.15481622517108917,
1.5054384469985962,
-0.3226109445095062,
-0.44685429334640503,
0.09039153158664703,
-0.4660315215587616,
-1.280641794204712,
0.030290061607956886,
0.29765042662620544,
1.7102527618408203,
1.7835278511047363,
-0.9451917409896851,
-0.1878727525472641,
-0.5955223441123962,
-1.3653873205184937,
0.8332366347312927,
0.31337010860443115,
-0.9735767245292664,
0.1273403912782669,
-0.8800417184829712,
-0.7051134705543518,
0.6085484623908997,
-0.4619627594947815,
-0.2903936803340912,
-1.2734949588775635,
-0.9319729804992676,
0.7310351729393005,
0.7341163158416748,
-0.40725192427635193,
-0.9135813117027283,
-0.5511360168457031,
0.4927617907524109,
1.1907352209091187,
0.03709656745195389,
-0.7213200330734253,
-0.09242179989814758,
-0.12860137224197388,
-0.5915586352348328,
0.42120790481567383,
-1.1856846809387207,
0.09332358837127686,
0.41910451650619507,
1.109712839126587,
-0.34088239073753357,
-0.7635051608085632,
-0.06043696030974388,
0.7461162805557251,
1.3497791290283203,
-0.5235311985015869,
-0.7594292163848877,
0.7315559983253479,
0.24435101449489594,
0.6803781986236572,
-0.3469219207763672,
-0.010116009041666985,
0.2892049252986908,
0.48966220021247864,
-0.16523556411266327,
-0.39243531227111816,
-0.09194279462099075,
-0.48953789472579956,
1.2266309261322021,
0.7788364291191101,
-0.19376236200332642,
-0.39226698875427246,
-0.8282883167266846,
-0.36384260654449463,
-0.009851924143731594,
0.5776276588439941,
-0.4204694926738739,
-0.01897100731730461,
-0.11123675107955933,
0.11495623737573624,
0.11418857425451279,
-0.642496645450592,
-0.399890273809433,
1.133805274963379,
0.5160281658172607,
-0.4517934024333954,
-0.43184250593185425,
0.08914854377508163,
-0.31135275959968567,
-0.7075040936470032,
-0.2965155839920044,
-0.4210728704929352,
0.2130366712808609,
0.029366740956902504,
-0.47338753938674927,
-0.727280855178833,
0.40011483430862427,
-0.31111791729927063,
0.3328968286514282,
-0.5008021593093872,
0.1387616991996765,
-0.1885942965745926,
0.6004173755645752,
0.07871922105550766,
0.3299926817417145,
1.3606001138687134,
-0.11540312319993973,
-0.33494797348976135,
-0.37647518515586853,
0.551899790763855,
0.20477579534053802,
-0.02224285714328289,
-0.010674565099179745,
0.14775137603282928,
0.32511433959007263,
0.34636247158050537,
-0.053286369889974594,
-0.04091185703873634,
-0.4142338037490845,
0.07798809558153152,
-0.33210018277168274,
0.06441018730401993,
-0.14342911541461945,
-0.0766260027885437,
0.22666220366954803,
0.08896167576313019,
-0.3999083638191223,
0.19624339044094086,
-0.0872502475976944,
-0.2972269356250763,
0.21393214166164398,
-0.54976487159729,
-0.02965678833425045,
-0.653891921043396,
0.027801264077425003,
-0.16938436031341553,
-0.2874900698661804,
0.35966700315475464,
0.2680389881134033,
0.05109706148505211,
-0.05825793370604515,
-0.11596440523862839,
0.30051741003990173,
-0.7024040222167969,
-0.49014103412628174,
-0.32814860343933105,
-0.26669996976852417,
-0.012751419097185135,
-0.45070967078208923,
0.5859493017196655,
0.03626474365592003,
-0.21483869850635529,
-0.11527678370475769,
-0.5503746271133423,
-0.42694225907325745,
0.41169238090515137,
-0.48172956705093384,
0.02478981763124466
] |
6,818,596 |
Effect of chlorpromazine on H-reflex recovery curves in normal subjects and schizophrenic patients.
|
Metz J J, Holcomb H H HH, Meltzer H Y HY
|
Psychopharmacology . Vol. 78, No. 4, 1982
|
This study sought to determine the effect of chlorpromazine (CPZ) on a physiological measure, the H-reflex recovery curve (HRRC) and to determine whether the effect is different in normal subjects and schizophrenic patients. Eleven normal control subjects and 14 patients were administered 12.5 and 25.0 mg CPZ by IM injection. On the average. HRRCs measured 90 min after the injections were lower compared to pre-injection levels in both groups, at both doses. In general, the higher dose was more effective in both groups. Half of the patients, however, failed to respond to 12.5 mg, indicating that some schizophrenics are less sensitive than normals to CPZ. These results indicate that excessive dopamine activity or sensitivity may underlie abnormally high HRRCs in unmedicated psychotic patients.
|
https://pubmed.ncbi.nlm.nih.gov/6818596/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] |
6818596
|
[
-0.4540824592113495,
1.6750366687774658,
-1.6523337364196777,
-1.6465085744857788,
1.5594340562820435,
0.547664999961853,
0.4347059428691864,
-0.30923041701316833,
0.164100781083107,
-0.4830723702907562,
0.218393936753273,
3.5978190898895264,
-0.4884425401687622,
0.9292131066322327,
-0.35345056653022766,
1.2740870714187622,
-0.6026368737220764,
0.1207866221666336,
1.543179988861084,
-1.4283552169799805,
-0.9871200323104858,
0.08411580324172974,
-0.039910443127155304,
0.8411921858787537,
0.4713747203350067,
-0.6286410689353943,
0.30150696635246277,
2.400022506713867,
0.09398028999567032,
0.5955747961997986,
0.42174580693244934,
0.15490680932998657,
0.6940409541130066,
0.004615697078406811,
-0.20565170049667358,
-0.6751147508621216,
1.5069652795791626,
-0.33290162682533264,
-0.09006525576114655,
-0.9690728783607483,
0.5649122595787048,
0.7462421655654907,
0.2207118719816208,
-0.6506339311599731,
1.2614983320236206,
0.8563216924667358,
-0.12184198945760727,
0.272322416305542,
0.7941133379936218,
-0.5990526676177979,
-0.7116864323616028,
0.7668601274490356,
-1.1782153844833374,
0.9031514525413513,
1.7533038854599,
-0.18623951077461243,
0.4330523908138275,
0.7441664934158325,
1.2074519395828247,
-0.197189599275589,
1.0241656303405762,
0.5511181950569153,
0.4615897834300995,
0.825660765171051,
0.08346113562583923,
0.7398180365562439,
0.960664689540863,
0.7006322145462036,
-0.6882650852203369,
1.3174059391021729,
-0.38024193048477173,
0.17686589062213898,
0.4760337769985199,
0.6235092878341675,
0.581657350063324,
0.2967529892921448,
-0.13860668241977692,
1.5714128017425537,
0.5807797908782959,
0.32568320631980896,
-1.0710673332214355,
-0.1883997619152069,
-0.6543471217155457,
0.39717942476272583,
1.3993161916732788,
0.1530347317457199,
-0.952215850353241,
-0.2991868257522583,
0.5450090765953064,
-1.2969626188278198,
-0.2518519163131714,
-0.33222532272338867,
-0.9861305952072144,
0.6033868193626404,
-0.4857484698295593,
0.9967585802078247,
0.13857422769069672,
0.6828977465629578,
-0.12113054096698761,
0.12763436138629913,
0.6352680325508118,
0.02395877055823803,
-0.5059234499931335,
-0.2834886908531189,
-0.6951168775558472,
-0.06946516782045364,
-0.32063812017440796,
-1.0806245803833008,
-0.5326542258262634,
-0.3284852206707001,
-0.22905486822128296,
-0.07756960391998291,
-0.41759994626045227,
-0.4962986707687378,
1.0748622417449951,
0.604947030544281,
0.37313830852508545,
-0.0597691684961319,
-0.2640588879585266,
-0.543470025062561,
-0.10801980644464493,
0.7817761898040771,
-0.6886322498321533,
-0.0822308138012886,
-0.10750214010477066,
-0.6233059763908386,
0.46942171454429626,
-0.8446095585823059,
-0.711427628993988,
-0.20114099979400635,
-0.5516071319580078,
0.3000974953174591,
-0.3290052115917206,
-0.6583709716796875,
-1.0931565761566162,
-0.49953970313072205,
0.5650949478149414,
1.242898941040039,
0.054846636950969696,
-0.22977623343467712,
0.56931072473526,
0.7415640950202942,
-0.6366696357727051,
-0.012879930436611176,
-1.244724988937378,
-0.1516871154308319,
-0.2364538609981537,
0.17328882217407227,
-0.5423654913902283,
-0.24913650751113892,
0.0270491074770689,
0.1644376516342163,
0.1712741255760193,
0.33959171175956726,
-0.4010300934314728,
0.17720653116703033,
0.22456198930740356,
0.6993703842163086,
0.031421780586242676,
-0.5749219059944153,
0.03389139845967293,
-0.2292596995830536,
-0.5999630093574524,
-0.2492501437664032,
0.5901777744293213,
-0.422844260931015,
0.027777476236224174,
-0.16467201709747314,
0.5689135789871216,
0.007032379042357206,
-0.9463127255439758,
0.1768019199371338,
0.05717755854129791,
0.5008115768432617,
-0.1526878923177719,
-0.1695285588502884,
-0.09601867198944092,
0.021353719756007195,
0.9277209639549255,
-0.5435864329338074,
0.38020315766334534,
0.2178245186805725,
0.31776776909828186,
-0.41925397515296936,
0.1253613531589508,
-0.9414642453193665,
0.04662162438035011,
-0.728123664855957,
0.028678743168711662,
0.00549118360504508,
-0.38690635561943054,
-0.34019988775253296,
0.12785564363002777,
-0.138017937541008,
0.5258663892745972,
-0.08306199312210083,
-0.7833117246627808,
-0.47294509410858154,
0.4669813811779022,
-0.2066544145345688,
0.1001909077167511,
0.13082735240459442,
0.14298558235168457,
0.8057636022567749,
-0.1528013050556183,
0.030880915001034737,
-0.018414542078971863,
0.738681972026825,
-0.33031922578811646,
0.672676682472229,
0.20920225977897644,
0.11586771160364151,
-0.49514469504356384,
-0.21418286859989166,
0.17701144516468048,
0.4676769971847534,
0.11770522594451904,
-0.11829213052988052,
-0.20255239307880402,
-0.05844271555542946,
-0.479491651058197,
-0.28586846590042114,
-0.02584625594317913,
0.2953592538833618,
0.26367685198783875,
-0.6652215123176575,
-0.04520018771290779,
-0.13571137189865112,
-0.14961041510105133,
0.10379108041524887,
-0.46748077869415283,
0.23231706023216248,
-0.39519834518432617,
-0.0558156743645668,
0.0785171166062355,
-0.29167690873146057,
0.06487608700990677,
0.26347655057907104,
0.05260065570473671,
0.27470672130584717,
-0.10668051242828369,
-0.24866792559623718,
-0.022592734545469284,
-0.052464958280324936,
-0.02157636731863022,
-0.12682904303073883,
0.06213321536779404,
0.541265070438385,
0.17747613787651062,
0.2329709380865097,
-0.1962478905916214,
-0.4725431203842163,
0.004231937229633331,
0.022415727376937866,
-0.3860858380794525,
0.22228844463825226
] |
6,818,599 |
Conditioned tolerance to the tachycardia effect of ethanol in humans.
|
Dafters R R, Anderson G G
|
Psychopharmacology . Vol. 78, No. 4, 1982
|
Human subjects were given a series of oral ethanol administrations in one environment and an equal number of placebo administrations in another distinct environment. Tolerance (a decreasing response with repeated administrations) to the tachycardia effect of ethanol was observed; no consistent changes in heart rate followed placebo administrations. Subsequently, tolerance to a test dose of ethanol administered in the environment normally associated with placebo was reduced relative to that in response to a dose administered in the usual ethanol environment. This demonstration of environment-specificity in a human drug tolerance experiment replicates previous reports from animal studies, and is interpreted according to a Pavlovian conditioning model of drug tolerance.
|
https://pubmed.ncbi.nlm.nih.gov/6818599/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6818599
|
[
-0.0157434344291687,
3.198429584503174,
-2.0310966968536377,
-0.482500821352005,
-0.34392666816711426,
-0.22959399223327637,
-0.16311882436275482,
-0.9912347793579102,
-1.3782896995544434,
-1.2582838535308838,
0.5087540745735168,
2.4847044944763184,
-0.46654003858566284,
1.0927869081497192,
0.034994591027498245,
0.014415664598345757,
-1.1571500301361084,
0.7899398803710938,
0.9924660325050354,
-1.3787213563919067,
0.05804936960339546,
-1.049988031387329,
-1.8242859840393066,
0.11777526140213013,
-0.6246463060379028,
-1.2088671922683716,
0.19567613303661346,
-0.2280736267566681,
-0.4713886082172394,
2.260209321975708,
-0.33590638637542725,
-0.5825755596160889,
-0.5810495018959045,
-0.065986767411232,
1.0993306636810303,
1.1561838388442993,
1.4288078546524048,
1.1283057928085327,
-0.972316563129425,
0.4688830077648163,
-0.002789650810882449,
-0.2113451212644577,
0.8519717454910278,
-1.5102810859680176,
1.3628865480422974,
1.28072988986969,
-1.584176778793335,
0.11129254102706909,
0.1430373191833496,
0.10742653161287308,
0.6508541703224182,
1.4430354833602905,
0.1291799545288086,
-0.27922889590263367,
2.8069522380828857,
-0.4188348948955536,
1.2242152690887451,
-0.13564004004001617,
1.3351325988769531,
-0.7912337779998779,
-0.7759621143341064,
-0.6585915088653564,
-0.2212987095117569,
1.3247504234313965,
-0.9511380195617676,
-0.1049114316701889,
1.9856468439102173,
0.12058451026678085,
-1.4657682180404663,
0.9823615550994873,
-0.184072807431221,
0.8029155731201172,
0.1024201512336731,
1.0929855108261108,
-0.6905506253242493,
-0.068881556391716,
-0.7122372984886169,
-0.6448917984962463,
0.4352834224700928,
0.1680637001991272,
-0.2790776789188385,
-1.2317116260528564,
0.24346491694450378,
-0.5317285656929016,
0.4434479773044586,
0.862783670425415,
-0.32423514127731323,
0.5319686532020569,
0.10278461873531342,
-0.3988402783870697,
-0.359667032957077,
-0.3230160176753998,
-1.9545800685882568,
0.029254505410790443,
-0.044914886355400085,
-0.3372284173965454,
-0.24155940115451813,
0.46029239892959595,
-0.3457244634628296,
-0.47300446033477783,
0.8097135424613953,
-0.20242230594158173,
0.27690601348876953,
0.10974928736686707,
-0.95611971616745,
0.10230040550231934,
-0.4339960217475891,
-0.09941240400075912,
-0.5087593197822571,
-0.3967679738998413,
-0.4597819447517395,
0.7136039733886719,
0.25542154908180237,
-0.8687219023704529,
1.0727897882461548,
-0.364651620388031,
-0.47583961486816406,
0.5531766414642334,
-0.7631632685661316,
-0.16734640300273895,
0.5760862827301025,
0.29058369994163513,
1.2549160718917847,
0.19401726126670837,
-0.07309243083000183,
-0.3437374234199524,
0.4167034327983856,
0.05190258473157883,
-0.9206109046936035,
-0.6393478512763977,
0.3119378685951233,
-0.2681978642940521,
-0.10204999148845673,
-0.7171260118484497,
-1.205276608467102,
-1.1518810987472534,
-0.2307804822921753,
1.6347956657409668,
0.9825641512870789,
-0.2606574594974518,
0.07778898626565933,
0.9210476279258728,
0.3780350387096405,
0.2526477575302124,
-0.672917902469635,
0.2708668112754822,
-0.6705174446105957,
0.3640734851360321,
0.10280376672744751,
-0.540977954864502,
-0.4148712158203125,
0.6115239262580872,
0.04627151042222977,
-0.06182730570435524,
-1.1663070917129517,
-0.37409868836402893,
0.19718918204307556,
0.2710549831390381,
0.16989248991012573,
-0.5931761860847473,
0.29982587695121765,
0.3455144464969635,
-0.1787654161453247,
0.6083590388298035,
0.3330807685852051,
0.07862915098667145,
-1.0258198976516724,
-0.04949108511209488,
-0.18713416159152985,
0.428816020488739,
-0.7126008868217468,
0.572414219379425,
0.1636626422405243,
0.8457733988761902,
0.2897423505783081,
-0.29126957058906555,
0.004283021204173565,
0.07378678023815155,
0.4837234914302826,
-0.4851951599121094,
-0.07602677494287491,
0.33663588762283325,
0.38678473234176636,
0.20063570141792297,
-0.237031489610672,
-0.3551993668079376,
0.5105183124542236,
-0.35290223360061646,
-0.005521860439330339,
-0.1620391607284546,
-0.11307164281606674,
0.3387101888656616,
0.08008897304534912,
-0.026260297745466232,
0.6692274212837219,
-0.08616503328084946,
0.3878861665725708,
0.08654899895191193,
0.5005767941474915,
-0.33835577964782715,
-0.20633073151111603,
0.697250485420227,
-0.5030537843704224,
0.2977900207042694,
-0.30622464418411255,
0.2285124808549881,
0.2649143934249878,
-0.41254088282585144,
-0.49812257289886475,
-0.1967274695634842,
-0.4767264425754547,
-0.8231961131095886,
-0.5745252370834351,
0.4643213152885437,
0.04449664056301117,
0.3882080316543579,
0.17114119231700897,
0.1433737725019455,
-0.08189775049686432,
-0.037029169499874115,
-0.01911371946334839,
-0.03720248118042946,
-0.675718367099762,
-0.025828544050455093,
-0.42158740758895874,
0.053062163293361664,
0.016620831564068794,
-0.7538021802902222,
-0.11923607438802719,
0.01648304983973503,
-0.4659961760044098,
-0.15141144394874573,
-0.47931167483329773,
-0.26144635677337646,
-0.3897939622402191,
-0.09526524692773819,
-0.001513649127446115,
0.1376212239265442,
0.3615961968898773,
-0.5642547607421875,
0.12565194070339203,
-0.5798227190971375,
-0.4978081285953522,
-0.017826275900006294,
0.4242447018623352,
0.2403305619955063,
-0.054671768099069595,
0.17256879806518555,
-0.6158537864685059,
-0.14069761335849762,
-0.4708312153816223,
-0.24922704696655273,
-0.22400124371051788,
-0.0028321926947683096,
-0.21319767832756042,
-0.5738033652305603
] |
6,818,684 |
Lactose malabsorption and tolerance of lactose-hydrolyzed milk. A double-blind controlled crossover study.
|
Rask Pedersen E E, Jensen B H BH, Jensen H J HJ, Keldsbo I L IL, Hylander Møller E E, Nørby Rasmussen S S
|
Scandinavian journal of gastroenterology . Vol. 17, No. 7, 1982 Oct
|
Eleven lactose-intolerant patients were investigated in a double-blind crossover controlled study. In random sequence they received 500 ml of either ordinary cow milk (lactose content, 25 g) or the same amount of low-lactose milk (85% of the lactose hydrolyzed), which had been processed by Lactozym 3000 L for 24 h at 4 degrees C. A significantly increased blood glucose rise from fasting levels was demonstrated in the low-lactose tests. Similarly, a significant reduction of liquid stool frequency, abdominal colics, distention, borborrhygmia, and flatulence was demonstrated. It was concluded that further studies, including long-term treatment of lactose-intolerant children, are indicated.
|
https://pubmed.ncbi.nlm.nih.gov/6818684/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6818684
|
[
0.24776212871074677,
0.3069879114627838,
-0.9802848696708679,
-2.8669145107269287,
0.43836861848831177,
2.2408652305603027,
-0.8390446305274963,
-1.3212618827819824,
-2.198625087738037,
-0.1910262405872345,
0.6322357058525085,
0.5060986280441284,
-0.4297485947608948,
1.1105477809906006,
-0.001781689701601863,
-0.7219957709312439,
-1.0423527956008911,
-0.4663853347301483,
0.3484925329685211,
-0.9403987526893616,
0.7485880851745605,
-0.09726135432720184,
-1.989522933959961,
-0.7984850406646729,
2.052039623260498,
-1.0273104906082153,
1.5996110439300537,
0.8947378993034363,
-0.11972304433584213,
0.4463345408439636,
0.48008713126182556,
0.578869640827179,
-1.0370129346847534,
-1.0695269107818604,
0.5715599060058594,
-1.2520674467086792,
-0.5015599727630615,
0.02122546173632145,
0.18171381950378418,
-0.8813516497612,
0.9431481957435608,
0.748443603515625,
0.7586622834205627,
-0.45278921723365784,
1.7820957899093628,
0.8464807271957397,
1.7229472398757935,
-1.5136276483535767,
-0.363274484872818,
1.4692882299423218,
0.10854233056306839,
0.9557722806930542,
-1.5998138189315796,
-0.11302170157432556,
0.6449424028396606,
2.005978584289551,
0.12607082724571228,
-0.3645740747451782,
2.491671085357666,
-0.4578115940093994,
0.9246239066123962,
0.5637823939323425,
-0.4226851165294647,
-0.2768124043941498,
-0.39447659254074097,
0.3875993490219116,
1.1823164224624634,
-0.42972588539123535,
-1.2043614387512207,
0.8631676435470581,
-0.933480441570282,
-0.7551360726356506,
-0.5644108653068542,
0.8241520524024963,
0.530393123626709,
0.4072241187095642,
0.5418446660041809,
0.18694691359996796,
0.8444332480430603,
0.15345530211925507,
-0.9579782485961914,
-0.33490633964538574,
0.10949435085058212,
-0.35581648349761963,
0.6493635177612305,
-0.051619067788124084,
-1.0115505456924438,
-1.0014766454696655,
-0.45212623476982117,
-0.8964794278144836,
0.19843542575836182,
-1.426435112953186,
-1.5574926137924194,
-0.12625004351139069,
0.33126509189605713,
-0.800797700881958,
0.5844792127609253,
-0.5966850519180298,
-0.2930293381214142,
-0.056425463408231735,
0.5759120583534241,
-0.6388790607452393,
-0.28645220398902893,
0.017535792663693428,
-0.13839784264564514,
-0.054506294429302216,
0.7056509256362915,
-0.4539126753807068,
-1.4014042615890503,
-0.008090037852525711,
-0.24153022468090057,
-0.6111663579940796,
-0.3379930257797241,
-0.5151094794273376,
1.0644102096557617,
0.45657801628112793,
-0.1393527388572693,
0.07119351625442505,
0.5561206340789795,
-0.292576402425766,
-0.046874646097421646,
1.2059487104415894,
0.11960794776678085,
0.5743553042411804,
0.0572192519903183,
-0.36487191915512085,
0.6845363974571228,
0.29209181666374207,
-0.3017137050628662,
-0.017550094053149223,
-0.7008628249168396,
0.704424262046814,
-0.20418085157871246,
-0.4247632920742035,
-0.21803626418113708,
0.24100880324840546,
-0.359942227602005,
0.9744617342948914,
0.517879843711853,
-0.6785091757774353,
-0.511721134185791,
0.42265576124191284,
-0.8752123713493347,
0.6896011233329773,
-0.7932961583137512,
-0.6323955655097961,
-0.6377969980239868,
0.22769145667552948,
-0.8705049753189087,
0.07325562089681625,
0.4799875020980835,
0.004469177685678005,
0.5606293678283691,
0.37272098660469055,
-0.023048769682645798,
0.23289793729782104,
-0.0006334295030683279,
0.3417279124259949,
0.3475193977355957,
-0.6896339058876038,
1.1283546686172485,
0.3752126693725586,
-0.04270713031291962,
-0.5060511827468872,
0.003929352853447199,
-0.0024683335795998573,
0.07499551773071289,
-0.5041993260383606,
-0.4367448389530182,
-0.18547233939170837,
-0.5987865924835205,
0.49873489141464233,
-0.4971030056476593,
0.0703740268945694,
0.3923555016517639,
-0.24449805915355682,
-0.13092932105064392,
0.14401794970035553,
0.45900416374206543,
-0.252194881439209,
-0.17622138559818268,
-0.4351077675819397,
-0.30869966745376587,
-0.22762148082256317,
-0.7220491170883179,
-0.5527397990226746,
0.26843777298927307,
0.10825461894273758,
-0.33049672842025757,
0.03125700354576111,
0.15670667588710785,
0.34104979038238525,
0.4034673869609833,
-0.2819897532463074,
0.21588265895843506,
0.25815722346305847,
-0.07304045557975769,
0.2705684006214142,
0.2889803647994995,
-0.03820345550775528,
0.5518440008163452,
0.6895625591278076,
0.11625131964683533,
0.37782320380210876,
-0.23385493457317352,
-0.13374198973178864,
0.2170739322900772,
0.889575719833374,
-0.7619346976280212,
0.3047334849834442,
0.3697122633457184,
0.040519483387470245,
-0.241102397441864,
-0.03188043087720871,
-0.27025559544563293,
0.4557890295982361,
0.24037516117095947,
0.30992311239242554,
-0.4401766061782837,
-0.17351675033569336,
0.07325413078069687,
0.009816339239478111,
0.32461920380592346,
-0.0020115363877266645,
-0.10233452916145325,
0.3695007562637329,
-0.030749037861824036,
0.2450897991657257,
-0.20038563013076782,
0.24680271744728088,
-0.47841712832450867,
-0.07258884608745575,
-0.7265068292617798,
-0.19256453216075897,
-0.7579222917556763,
0.6154287457466125,
-0.23051442205905914,
-0.22431552410125732,
0.23516139388084412,
-0.2532940208911896,
-0.1978575438261032,
-0.37963148951530457,
0.0618613176047802,
0.1391640454530716,
0.27949294447898865,
0.2365231066942215,
-0.37182939052581787,
0.15261442959308624,
0.25933992862701416,
-0.06908607482910156,
-0.05115330591797829,
-0.39287737011909485,
0.37608450651168823,
0.2619576156139374,
0.0718291699886322,
-0.0887516513466835
] |
6,818,707 |
Dose-response study of sodium cromoglycate in exercise-induced asthma.
|
Patel K R KR, Berkin K E KE, Kerr J W JW
|
Thorax . Vol. 37, No. 9, 1982 Sep
|
Ten patients with exercise-induced asthma participated in a single-blind dose-response study comparing the protective effect of inhaled sodium cromoglycate in increasing concentrations from 2 to 40 mg/ml. Saline was used as a control. Effects were assessed from the mean maximal percentage fall in forced expiratory volume in one second (FEV1) after the patients had run on a treadmill for eight minutes. There was slight bronchodilation evident from the increase in baseline FEV1 after inhalation of sodium cromoglycate, the difference reaching statistical significance with the highest concentration (5.7%, p less than 0.05). After exercise the maximal percentage falls in FEV1 (means and SEM) after saline and after sodium cromoglycate at 2, 10, 20, and 40 mg/ml were 37.3 +/- 4.7, 17.3 +/- 4.1, 10 +/- 3.3, 7.6 +/- 2.4, and 12 +/- 2.9. Sodium cromoglycate inhibited the exercise-induced fall in FEV1 at all the concentrations used in the study (p less than 0.001) and its inhibitory effect increased from 2 to 20 mg/ml. The mean FEV1 returned to baseline values within 15 minutes at higher concentrations of sodium cromoglycate (20 and 40 mg/ml) and a small bronchodilator effect was noted at 30 minutes. The findings suggest that the protective effect of sodium cromoglycate in exercise asthma is dose related. At higher concentration the drug suppresses chemical mediator release from the lung mast cells and may also modify the bronchial reactivity to release mediators.
|
https://pubmed.ncbi.nlm.nih.gov/6818707/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6818707
|
[
-1.1290168762207031,
0.8486559391021729,
-1.2565486431121826,
-2.690582275390625,
1.1215533018112183,
0.9816587567329407,
0.09315689653158188,
-0.6568847298622131,
-0.5132302641868591,
-0.3649061322212219,
-0.1804293990135193,
1.7269182205200195,
-0.2399749606847763,
0.45581772923469543,
0.015926215797662735,
-0.2971233129501343,
-1.0363216400146484,
0.2597694396972656,
1.2543448209762573,
-1.3710200786590576,
0.9127200841903687,
-0.622079074382782,
-0.19946634769439697,
0.3695235848426819,
0.8214689493179321,
-0.5270583033561707,
0.872316300868988,
0.7212420105934143,
0.8421878814697266,
0.6947230696678162,
-0.5248585343360901,
-1.3787665367126465,
0.8839466571807861,
-0.6253482699394226,
-0.1993928700685501,
-0.13033001124858856,
0.4629157483577728,
-0.7166522145271301,
0.9177709221839905,
-0.3730178773403168,
0.045576829463243484,
0.3989464044570923,
0.5649194121360779,
-1.0245296955108643,
1.04475998878479,
0.2337222695350647,
0.4440085291862488,
-0.2836265563964844,
-0.0463997945189476,
0.9540228247642517,
-0.1025857925415039,
0.5521697402000427,
-0.6981496810913086,
-0.8112354278564453,
2.571094512939453,
-0.18654638528823853,
0.3662654757499695,
0.12015226483345032,
0.6309736371040344,
-0.6480942368507385,
0.3476901352405548,
0.3819577395915985,
0.5731093883514404,
-0.00954955630004406,
-0.06975719332695007,
-0.34444519877433777,
0.2558198571205139,
0.2034303843975067,
-0.9495734572410583,
0.07793799787759781,
-0.7019546031951904,
-0.1550886482000351,
-0.10880135744810104,
0.09428644925355911,
0.9246888160705566,
0.529846727848053,
0.517187774181366,
0.21216987073421478,
0.32974958419799805,
0.5582821369171143,
-1.1524356603622437,
-0.5061547160148621,
-0.3712265193462372,
0.16329580545425415,
0.3666434586048126,
0.15531805157661438,
-0.46366411447525024,
-0.26744017004966736,
0.09967099130153656,
-1.3963760137557983,
-0.1316528171300888,
-1.3840022087097168,
-1.1970791816711426,
0.42490270733833313,
-0.2712966501712799,
0.5817947387695312,
0.7254538536071777,
0.6676543354988098,
0.00656444625928998,
-0.4438576400279999,
0.04136526584625244,
0.4900064766407013,
-0.03310682252049446,
0.1714480072259903,
-0.5790830850601196,
-0.10251666605472565,
-0.27183452248573303,
-0.6838542819023132,
-0.5866641998291016,
-0.3767589330673218,
-0.12470957636833191,
-0.5951426029205322,
0.09588994830846786,
-0.7345413565635681,
0.5709930658340454,
0.043007928878068924,
-0.2885909080505371,
0.015439883805811405,
0.12513597309589386,
-1.0037795305252075,
0.6047472953796387,
0.010524850338697433,
-0.49811890721321106,
0.1771591156721115,
0.14281830191612244,
-0.23438237607479095,
-0.01117934100329876,
0.3840480446815491,
-0.14871415495872498,
-0.6314342021942139,
-0.47098469734191895,
0.08526244014501572,
-0.13413846492767334,
0.06906810402870178,
-0.6720978617668152,
-0.4225543439388275,
-0.100936658680439,
0.1610027253627777,
0.3889254629611969,
0.06186424195766449,
-0.28207555413246155,
0.009713762439787388,
-0.2927487790584564,
0.06857280433177948,
-1.0188828706741333,
-0.030631795525550842,
-0.5184846520423889,
-0.06317397207021713,
-0.576583743095398,
-0.14114035665988922,
0.6007943749427795,
-0.16238853335380554,
0.36333921551704407,
-0.20372800529003143,
0.018711494281888008,
-0.04365343600511551,
0.37462320923805237,
0.02411917969584465,
-0.23862461745738983,
0.11385655403137207,
0.88902348279953,
0.2770231366157532,
-0.28247660398483276,
0.01169533096253872,
0.40399158000946045,
0.1925434172153473,
0.17024889588356018,
-0.5492920279502869,
0.31794193387031555,
-0.17564649879932404,
-0.7917786240577698,
-0.6273746490478516,
0.1915273815393448,
0.27059170603752136,
0.3243730664253235,
-0.4201495945453644,
0.7825540900230408,
0.37238064408302307,
0.46904683113098145,
0.22784492373466492,
0.2024025022983551,
0.28282463550567627,
-0.1416160613298416,
-0.2971670925617218,
-0.11129513382911682,
-0.627368152141571,
-0.30140992999076843,
-0.2559290826320648,
0.3277110457420349,
-0.18524473905563354,
0.3247746229171753,
-0.004126781597733498,
-0.2808539867401123,
-0.2406691014766693,
0.4164774715900421,
0.15286265313625336,
-0.5262903571128845,
0.1668849140405655,
0.15453729033470154,
-0.016126763075590134,
0.46879056096076965,
0.04566720873117447,
0.16233588755130768,
0.4844669699668884,
0.2644951343536377,
-0.35004061460494995,
-0.01828635297715664,
-0.029984110966324806,
-0.4571670889854431,
0.07061705738306046,
0.1770610511302948,
0.21994373202323914,
-0.12000947445631027,
-0.014632166363298893,
0.29555049538612366,
-0.05120693892240524,
-0.10832416266202927,
0.034864313900470734,
-0.29087892174720764,
0.30493560433387756,
-0.12000812590122223,
-0.06483760476112366,
0.05407039076089859,
0.09613204747438431,
0.01981281489133835,
-0.5720773339271545,
-0.14747361838817596,
0.28087520599365234,
0.034942470490932465,
-0.10584750771522522,
-0.3990113437175751,
-0.013083589263260365,
0.10368841141462326,
-0.4596920311450958,
-0.10370630770921707,
0.1357690542936325,
0.05545365810394287,
0.08825726807117462,
0.2149241417646408,
-0.09226979315280914,
-0.07308803498744965,
-0.48070165514945984,
-0.047681987285614014,
0.03804846480488777,
0.36926376819610596,
-0.3400750756263733,
0.002786654280498624,
0.5264118313789368,
-0.1812429577112198,
-0.2137301117181778,
0.17614568769931793,
-0.04027053341269493,
-0.2888577878475189,
0.4284856617450714,
-0.15699735283851624,
0.016506033018231392
] |
6,818,806 |
Oestrogens, gonadotrophins and SHBG during oral and cutaneous administration of oestradiol-17 beta to menopausal women.
|
Fåhraeus L L, Larsson-Cohn U U
|
Acta endocrinologica . Vol. 101, No. 4, 1982 Dec
|
Thirty-eight post-menopausal women were randomly allocated to 6 months of treatment with either 2-4 mg of micronized oestradiol-17 beta taken orally or 3 mg of oestradiol-17 beta applied cutaneously. The plasma concentrations of oestrone, oestradiol, LH, FSH and sex hormone binding globulin (SHBG) were determined twice before and after 2, 4 and 6 months of treatment. In both groups the clinical effects were satisfactory. During treatment the mean oestradiol levels showed similar increases in the two groups while the oestrone concentration was markedly raised only among those taking oestradiol orally. The mean LH and FSH concentrations were significantly lowered in both groups. SHBG was increased with both treatments although more marked in the group on oral medication. Doubling of the oral dose from 2 mg to 4 mg gave significant changes of the LH, FSH and oestrone concentrations. Thus, in the given doses, the two routes of administration seemed to have similar effects on post-menopausal symptoms and on the plasma concentrations of gonadotrophins and oestradiol. However the plasma oestrone and SHBG levels became significantly higher during the oral than during the cutaneous treatment.
|
https://pubmed.ncbi.nlm.nih.gov/6818806/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6818806
|
[
0.19165362417697906,
0.07542437314987183,
-2.0574469566345215,
-1.529976487159729,
0.8688463568687439,
0.5571833848953247,
0.7379438281059265,
-0.6967319846153259,
-1.6109977960586548,
0.17486608028411865,
0.5064694285392761,
0.8112406134605408,
0.38780078291893005,
0.2581227719783783,
0.30204010009765625,
0.04805736988782883,
-0.6343293190002441,
-0.16116861999034882,
1.7109692096710205,
-1.258284091949463,
0.7708000540733337,
-0.6072238683700562,
0.08526676893234253,
-1.0080257654190063,
0.29970598220825195,
-1.8420113325119019,
0.38201332092285156,
0.7349989414215088,
0.10014230012893677,
1.3361387252807617,
0.9671452641487122,
-0.5768222212791443,
0.8100674748420715,
-0.7966418266296387,
1.6168937683105469,
0.02380538173019886,
0.13920807838439941,
-0.0543278269469738,
0.3478480875492096,
-0.07648463547229767,
0.9574446082115173,
0.1740809977054596,
0.8741307258605957,
-1.271593689918518,
1.4043638706207275,
0.34826186299324036,
0.3111642599105835,
0.5402647256851196,
0.39705052971839905,
-0.39337071776390076,
-0.32892128825187683,
0.3992668688297272,
0.3299121856689453,
-0.17845815420150757,
1.39854896068573,
0.6058762073516846,
1.285207748413086,
-0.4476187229156494,
1.136763334274292,
-0.15244244039058685,
0.8859349489212036,
0.6244006156921387,
-0.2027561068534851,
0.007890963926911354,
-0.15840469300746918,
-0.2607666254043579,
-0.05848616361618042,
1.397085189819336,
-0.9308062195777893,
1.0534710884094238,
-0.7410247325897217,
-0.2903532385826111,
0.28404825925827026,
-0.1373467594385147,
0.8766174912452698,
0.47003528475761414,
-0.21524415910243988,
-0.08200938999652863,
1.2128477096557617,
-0.47406280040740967,
-0.01128680445253849,
0.624709963798523,
0.02438170649111271,
0.4084784984588623,
0.26866546273231506,
-0.09450028091669083,
-0.10250108689069748,
0.15595799684524536,
0.34378480911254883,
-0.7798144221305847,
-0.6614741086959839,
-0.2437189370393753,
-2.1757192611694336,
0.25022900104522705,
-0.5742655992507935,
0.5014646053314209,
0.5852156281471252,
0.05600930377840996,
-0.3249419927597046,
0.017267713323235512,
0.5455737709999084,
0.08911243826150894,
0.01661984622478485,
0.07377579063177109,
-0.6916413903236389,
-0.6134800910949707,
-0.1680232286453247,
0.06895290315151215,
-1.9593274593353271,
-0.7689842581748962,
-0.528237521648407,
-0.8467632532119751,
-0.6338726878166199,
0.1477116346359253,
0.5260809063911438,
0.9074218273162842,
-0.2538222074508667,
-0.3915747106075287,
-0.33596882224082947,
-0.5209972262382507,
0.7532181143760681,
0.7238290309906006,
-0.20212720334529877,
0.5445924401283264,
-0.10979627072811127,
-0.1192951500415802,
0.3186188340187073,
-0.5227161049842834,
0.04142969101667404,
-0.2146235704421997,
-0.4747481644153595,
0.5462252497673035,
0.3090914487838745,
-0.29010269045829773,
-1.5121960639953613,
-0.29298269748687744,
0.5850181579589844,
1.5968225002288818,
0.238911435008049,
-0.6449282169342041,
-0.47566497325897217,
0.13130517303943634,
-0.5324782133102417,
0.7725072503089905,
-1.6045663356781006,
0.01642952859401703,
-0.14275065064430237,
0.45683518052101135,
-0.3619804084300995,
-0.13597875833511353,
0.05660831928253174,
0.37866154313087463,
0.5693908929824829,
-0.4096008241176605,
-0.6351346373558044,
0.3712756931781769,
0.538026750087738,
0.17617365717887878,
0.43490070104599,
-0.21024523675441742,
0.10973597317934036,
-0.14527259767055511,
0.38192227482795715,
-0.10292905569076538,
0.21795666217803955,
0.2916094660758972,
0.22413195669651031,
-0.10642685741186142,
0.7273946404457092,
-0.23619769513607025,
-0.6939341425895691,
-0.3863060772418976,
0.2548866271972656,
0.27175694704055786,
0.24677912890911102,
0.3917848765850067,
0.45989492535591125,
0.147327721118927,
0.8973450660705566,
-0.10723139345645905,
-0.16990287601947784,
0.3738757371902466,
0.2536385953426361,
-0.741727352142334,
-0.2789986729621887,
-0.6202214956283569,
-0.3202819526195526,
0.04393192008137703,
0.21850599348545074,
0.24545899033546448,
0.41724950075149536,
0.4313320219516754,
-0.15113946795463562,
0.046304672956466675,
-0.10384838283061981,
-0.2792878746986389,
0.2616267800331116,
0.22663676738739014,
0.41398555040359497,
-0.34540364146232605,
0.04987845569849014,
0.878085196018219,
0.13756133615970612,
0.6095311045646667,
-0.080238476395607,
-0.47489598393440247,
-0.11573515087366104,
0.47440192103385925,
-0.5686321258544922,
0.1134817972779274,
-0.04941839724779129,
-0.06411361694335938,
0.30310624837875366,
0.49101901054382324,
0.2395130842924118,
0.6224916577339172,
-0.11160612106323242,
0.18379747867584229,
0.2675321400165558,
-0.05433197319507599,
-0.0714135393500328,
-0.3499600291252136,
-0.025168096646666527,
0.19197098910808563,
-0.5763775706291199,
0.20571286976337433,
0.24192552268505096,
0.3889772295951843,
-0.3403897285461426,
-0.010030136443674564,
-0.13984106481075287,
-0.09925089031457901,
0.04779285192489624,
-0.6421570777893066,
0.2561101019382477,
-0.4048207700252533,
0.03757452964782715,
0.007701758295297623,
-0.3069118857383728,
-0.1527387648820877,
0.02505519799888134,
-0.5191417932510376,
-0.20086757838726044,
-0.7332571744918823,
0.1872800588607788,
-0.132212296128273,
-0.1504727602005005,
0.6856482028961182,
-0.0018450681818649173,
0.008782312273979187,
-0.5154144167900085,
-0.11352118104696274,
-0.23078906536102295,
0.3523648977279663,
-0.4945007264614105,
-0.013717599213123322
] |
6,818,829 |
Preoperative timolol and ocular compression in cataract surgery.
|
Miettinen R R, Airaksinen P J PJ, Pihlajaniemi R R, Puhakka K K
|
Acta ophthalmologica . Vol. 60, No. 4, 1982 Aug
|
The intraocular pressure (IOP) reducing effect of topical timolol with digital ocular compression for the prevention of vitreous loss in cataract surgery was compared with the effect of combined acetazolamide-mannitol pre-medication with digital compression. In the timolol group of 30 patients the mean IOP reduced from 11.4 mmHg before the compression to 8.2 mmHg after it. In the acetazolamide-mannitol group of 29 patients the mean IOPs were 10.9 and 5.6 mmHg, respectively. The reduction of IOP was statistically highly significant in both groups. There was no case of vitreous loss and the post-operative healing was uncomplicated in both groups of patients. The application of timolol was easy and time saving, but acetazolamide-mannitol pre-medication created deeper hypotony after ocular compression, which was probably due to the vitreous reducing effect of mannitol.
|
https://pubmed.ncbi.nlm.nih.gov/6818829/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6818829
|
[
-0.13439299166202545,
-0.1713610738515854,
-2.5285401344299316,
-3.470489263534546,
0.24438470602035522,
0.13718686997890472,
0.49013933539390564,
0.6653881072998047,
-1.0398201942443848,
1.615612506866455,
-0.20086704194545746,
0.20821407437324524,
0.20741793513298035,
-0.6284720301628113,
0.0228178258985281,
-0.001506269909441471,
0.5662243366241455,
1.2115501165390015,
-1.353574514389038,
-1.1930960416793823,
1.4173569679260254,
-0.7662649154663086,
0.06039293482899666,
0.3077166974544525,
1.274287223815918,
-0.6284431219100952,
0.7951421737670898,
0.44972023367881775,
-0.0831332579255104,
0.72169429063797,
0.5097060799598694,
-0.46178704500198364,
1.1756675243377686,
0.14332915842533112,
-0.3782261908054352,
-0.415766179561615,
-0.8473578095436096,
0.9591837525367737,
-0.2941306531429291,
0.2972732186317444,
0.2899996042251587,
-0.19875310361385345,
0.3299669325351715,
-1.3287521600723267,
0.8491551876068115,
0.6029497385025024,
0.5591517090797424,
0.08777016401290894,
-0.015422523021697998,
0.2559604048728943,
-0.9927855134010315,
0.26444077491760254,
-0.3128880262374878,
1.544138789176941,
0.9425219297409058,
0.8150515556335449,
0.4659915864467621,
-0.055577315390110016,
-0.3152289092540741,
0.6236459016799927,
0.8820570111274719,
0.5568485856056213,
0.39060544967651367,
0.7526999711990356,
-0.9393705129623413,
-0.6583985090255737,
-0.5838088393211365,
0.19947806000709534,
-1.020769476890564,
0.42412707209587097,
-1.1638284921646118,
0.24129566550254822,
0.593882143497467,
0.1257951259613037,
0.609659731388092,
0.16688349843025208,
0.1424483358860016,
0.570050835609436,
0.5229857563972473,
0.46604689955711365,
-0.1283923238515854,
-0.6471521258354187,
-0.4143846929073334,
0.5055252313613892,
-0.28122591972351074,
0.013891094364225864,
-0.8045768141746521,
-0.8178596496582031,
-0.08490965515375137,
-0.6047866344451904,
0.7214234471321106,
-0.5480131506919861,
-1.2955009937286377,
0.7111374139785767,
-0.5144684314727783,
0.4132743179798126,
0.27346017956733704,
-0.5812597274780273,
-0.49047449231147766,
-0.2345472276210785,
0.9881362318992615,
-0.5866028666496277,
-0.40788307785987854,
-0.06996943801641464,
-0.04084622859954834,
0.03969675302505493,
-0.8266065716743469,
0.030504046007990837,
-1.2937607765197754,
-0.2355368733406067,
-0.23751558363437653,
-1.2600252628326416,
-1.1372781991958618,
-0.3886634111404419,
0.10049634426832199,
1.4398597478866577,
0.23270586133003235,
-0.33878347277641296,
-0.7912099957466125,
-0.4217909276485443,
-0.77498459815979,
0.5856346487998962,
0.5297267436981201,
1.5227807760238647,
0.019923755899071693,
0.2029251605272293,
-0.10085868835449219,
0.7911964654922485,
0.8058525919914246,
-0.11336414515972137,
0.05602490156888962,
0.2592630088329315,
0.4869270622730255,
-0.3498441278934479,
-1.6423877477645874,
0.011642778292298317,
-0.054921768605709076,
1.5196131467819214,
0.33101189136505127,
0.2761596441268921,
-0.038407593965530396,
0.1981964260339737,
-0.7669708728790283,
-0.4222433865070343,
-1.6152209043502808,
-1.0070335865020752,
-0.6302111744880676,
0.3349156379699707,
-0.9410384893417358,
-0.29799214005470276,
0.1093616783618927,
-0.3271789252758026,
0.5385080575942993,
-0.6149245500564575,
0.04669107124209404,
0.1684906780719757,
-0.40695229172706604,
0.2357914298772812,
0.3757528066635132,
-0.3521776795387268,
-0.16594074666500092,
-0.6289356350898743,
0.2953542172908783,
-0.027425702661275864,
0.2983705699443817,
-0.6618261933326721,
0.20827703177928925,
-0.2901262044906616,
0.7896487712860107,
-0.28017324209213257,
-1.3729090690612793,
0.3173007071018219,
-0.16051246225833893,
-0.04604251682758331,
-0.11471865326166153,
0.24250216782093048,
0.4072580337524414,
-0.1698642373085022,
-0.03116518259048462,
-0.06713517755270004,
-0.12451481074094772,
-0.5478236675262451,
-0.41473615169525146,
-0.20463190972805023,
-0.36864468455314636,
-0.12340221554040909,
-0.2833215296268463,
0.2981690764427185,
0.30055055022239685,
0.4899676740169525,
0.2878901958465576,
-0.3084358870983124,
-0.24353261291980743,
0.11771917343139648,
0.2456163763999939,
-0.44351816177368164,
-0.17518985271453857,
-0.3650170564651489,
0.043982524424791336,
0.03769602254033089,
-0.03331875801086426,
0.5673198699951172,
0.27455762028694153,
0.20445452630519867,
-0.0869775265455246,
-0.1890704333782196,
-0.4969799816608429,
0.3044603765010834,
-0.20608387887477875,
0.08753374218940735,
0.053789183497428894,
-0.4767022728919983,
0.027227383106946945,
0.49287551641464233,
0.2103576958179474,
-0.20655247569084167,
0.4165705740451813,
-0.43496230244636536,
-0.4480348825454712,
-0.12180685997009277,
0.11135131120681763,
-0.3511162996292114,
0.6201363801956177,
-0.1105617880821228,
-0.6148014664649963,
0.3111153542995453,
0.22324518859386444,
0.15723523497581482,
-0.3762668967247009,
0.24768032133579254,
0.005402912385761738,
0.014615402556955814,
-0.42297011613845825,
-0.3400871455669403,
0.27512064576148987,
-0.11592839658260345,
0.24080222845077515,
0.10677765309810638,
-0.1853046864271164,
-0.1359797865152359,
-0.32532110810279846,
-0.4478367865085602,
-0.4496740698814392,
0.008990406058728695,
-0.05325482413172722,
0.12808071076869965,
-0.08054641634225845,
0.42854687571525574,
-0.5795292854309082,
-0.06521551311016083,
0.17378759384155273,
0.26154813170433044,
-0.14869408309459686,
0.16900785267353058,
0.10113702714443207,
0.00363817997276783
] |
6,819,028 |
Dietary protein energy supplementation of pregnant Asian mothers at Sorrento, Birmingham. I: Unselective during second and third trimesters.
|
Viegas O A OA, Scott P H PH, Cole T J TJ, Mansfield H N HN, Wharton P P, Wharton B A BA
|
British medical journal (Clinical research ed.) . Vol. 285, No. 6342
|
At Sorrento Maternity Hospital Asian mothers whose babies had grown poorly in utero had anthropometric and biochemical evidence suggesting an inadequate nutritional state. To test this hypothesis further the effect of unselective dietary protein energy supplementation was studied. A total of 153 Asian mothers received one of three supplements from the 18th to 38th weeks of pregnancy: (a) vitamins only--vitamin C 30 mg daily, iron 3 mg daily; (b) energy--42-80 MJ; (10 000-19 000 kcal)/trimester, all from carbohydrate, plus vitamins; (c) protein energy--energy and vitamins as before, but with 5-11% of energy from milk protein. By the 28th week mothers receiving the protein energy supplement had put on more weight and more fat than the vitamin-only group. Neither protein energy nor energy supplementation alone enhanced intrauterine growth. It is concluded that dietary supplementation of all pregnant mothers does not enhance intrauterine growth.
|
https://pubmed.ncbi.nlm.nih.gov/6819028/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6819028
|
[
0.8942221403121948,
1.1934486627578735,
-1.3536107540130615,
-2.7653045654296875,
1.0375863313674927,
1.6290520429611206,
-1.166548728942871,
-0.6289348006248474,
-1.8065524101257324,
-0.9171839952468872,
0.6317312121391296,
2.067153215408325,
0.09077007323503494,
0.496640145778656,
-0.9295705556869507,
-1.1153925657272339,
-1.6842714548110962,
-0.1694919764995575,
-0.48929348587989807,
-1.522355318069458,
-0.17930036783218384,
-0.7345534563064575,
-0.36074721813201904,
-0.7597604990005493,
0.4769347012042999,
-0.19220733642578125,
-1.1667211055755615,
1.3666024208068848,
-0.3210296332836151,
-0.2110367864370346,
0.8761104941368103,
-0.6879831552505493,
-0.6290282607078552,
-0.5001304149627686,
0.5830726623535156,
0.32297512888908386,
1.9998711347579956,
-0.6095429062843323,
-0.8610957264900208,
0.6199504733085632,
0.6197811365127563,
-0.021658873185515404,
-0.5954728722572327,
1.4967249631881714,
1.3882575035095215,
-0.5920538902282715,
1.1049036979675293,
-1.1969069242477417,
0.15225964784622192,
0.9242668151855469,
-0.8662852048873901,
0.720720648765564,
-1.3953170776367188,
-1.28266179561615,
1.7691019773483276,
-0.09714818745851517,
0.9291152358055115,
-0.7133731842041016,
0.7619028687477112,
0.20781995356082916,
0.30109307169914246,
0.17610619962215424,
-0.6437366604804993,
0.3836330473423004,
-0.3742138743400574,
-1.373897910118103,
0.772636353969574,
0.1134534627199173,
-1.3506399393081665,
1.3288010358810425,
0.5881578922271729,
-0.25020286440849304,
-0.3539656102657318,
-1.1348257064819336,
1.2737394571304321,
1.2975057363510132,
-0.14486365020275116,
1.0732465982437134,
-0.0944320410490036,
-0.04901920631527901,
-0.357760488986969,
-0.507620632648468,
-0.50050288438797,
0.5869114398956299,
-0.33870401978492737,
1.1684324741363525,
-1.1829735040664673,
-0.12092716246843338,
1.104112148284912,
-1.67758309841156,
0.14732888340950012,
-0.8725873231887817,
-1.5073210000991821,
0.26010698080062866,
-0.31004929542541504,
0.6460529565811157,
0.5301250219345093,
0.1939239650964737,
0.46089255809783936,
-0.7227634191513062,
0.6231926083564758,
0.838813066482544,
-0.907389223575592,
0.9110528230667114,
-0.13186609745025635,
-0.35304227471351624,
0.0063253771513700485,
0.01031092181801796,
-0.8636053800582886,
0.15866148471832275,
-0.3046788275241852,
-0.504710853099823,
-1.1665141582489014,
-0.3591151535511017,
0.308909147977829,
1.1811497211456299,
-0.7591336965560913,
-0.16222795844078064,
0.26710066199302673,
-0.5224393606185913,
0.4114531874656677,
-0.3935743272304535,
-0.8364058136940002,
0.4906373620033264,
-0.6263540983200073,
-0.3767407536506653,
0.012219244614243507,
-0.6006271839141846,
0.2410377711057663,
-0.32362115383148193,
-0.5532571077346802,
0.6111081838607788,
0.6893192529678345,
-0.5243940949440002,
-0.13086116313934326,
0.18582291901111603,
0.7108744382858276,
-0.21035411953926086,
-0.6791119575500488,
-0.6303772926330566,
-0.7877519726753235,
-0.12528659403324127,
-0.7331423163414001,
0.31021782755851746,
-0.9574126601219177,
0.4905427396297455,
-0.31356167793273926,
-0.31189030408859253,
-0.19060717523097992,
0.6838927865028381,
0.10057984292507172,
0.4953976571559906,
0.21500620245933533,
-0.499432235956192,
-0.8283908367156982,
0.3725343644618988,
-0.806979775428772,
0.1624404340982437,
0.06033797934651375,
0.0063150436617434025,
0.6246842741966248,
-0.1726805567741394,
0.07632668316364288,
-0.09825118631124496,
-0.25450751185417175,
0.5284578800201416,
0.3045881390571594,
0.07345491647720337,
0.5508832335472107,
-0.03013387881219387,
0.03483227267861366,
0.3978523015975952,
-1.0271936655044556,
0.28646114468574524,
-0.03994464874267578,
-0.026007723063230515,
0.7772296071052551,
0.26956087350845337,
0.2796572744846344,
-0.33301374316215515,
-0.2989664375782013,
0.5204023122787476,
0.0038095430936664343,
-0.17775164544582367,
-0.4996521472930908,
-0.10458052903413773,
0.7383273839950562,
-0.23963531851768494,
-0.32111963629722595,
0.26580411195755005,
0.30773603916168213,
0.41582271456718445,
-0.17572976648807526,
-0.08366977423429489,
-0.5220178365707397,
0.19709743559360504,
0.31279128789901733,
-0.22801236808300018,
0.06992439180612564,
-0.07430554926395416,
-0.2116541713476181,
0.5468625426292419,
-0.3988497257232666,
0.1881861388683319,
-0.1234935075044632,
-0.07729937881231308,
0.20761537551879883,
0.2660087049007416,
-0.07073642313480377,
-0.17464099824428558,
0.6917152404785156,
0.5990825295448303,
0.2600894272327423,
0.44807350635528564,
0.06658054888248444,
-0.08531296253204346,
-0.34689080715179443,
0.24261176586151123,
0.09235551953315735,
-0.07012910395860672,
0.015369161032140255,
0.04115721210837364,
-0.4283651113510132,
-0.5150999426841736,
0.4783536493778229,
0.11205687373876572,
-0.22109809517860413,
0.24423402547836304,
-0.15435419976711273,
0.3802782893180847,
0.04889039695262909,
0.09382414072751999,
0.11834323406219482,
-0.20454265177249908,
-0.17082315683364868,
-0.027720553800463676,
-0.2606559991836548,
0.38891133666038513,
-0.1294625848531723,
-0.29976898431777954,
-0.3368982970714569,
-0.36050620675086975,
0.10989747196435928,
-0.07751834392547607,
0.0603676438331604,
-0.19029127061367035,
-0.036665864288806915,
0.22265507280826569,
-0.02511020563542843,
-0.5863944888114929,
0.4104161262512207,
0.4031732976436615,
0.15810905396938324,
-0.02843017876148224,
0.3221495449542999,
-0.13358229398727417
] |
6,819,029 |
Dietary protein energy supplementation of pregnant Asian mothers at Sorrento, Birmingham. II: Selective during third trimester only.
|
Viegas O A OA, Scott P H PH, Cole T J TJ, Eaton P P, Needham P G PG, Wharton B A BA
|
British medical journal (Clinical research ed.) . Vol. 285, No. 6342
|
Unselective dietary protein energy supplementation of Asian mothers at Sorrento Maternity Hospital did not enhance intrauterine growth. The effect of selective supplementation was therefore studied. Forty-five mothers who at 28 weeks were known to be nutritionally at risk (triceps increment less than or equal to 20 microns/week between 18 and 28 weeks) received one of three supplements during the third trimester: (a) vitamins only--a multivitamin sachet daily containing vitamins A, B, C, and D; (b) energy--42-125 MJ (10 000-30 000 kcal), all from carbohydrate, plus vitamins; (c) protein energy--energy and vitamins as before, but with 5-10% of energy from milk protein. Eighty-three mothers regarded as adequately nourished at 28 weeks also received one of the three supplements. In the nutritionally at-risk mothers the protein energy supplement was associated with a heavier crude birth weight and heavier weight for gestational age. Supplementation did not lead to improved intrauterine growth in those mothers who were adequately nourished. The differential effect of supplementation depending on the mothers' nutritional state during the second trimester may explain apparently conflicting results of other studies where some have shown a substantial effect of supplementation and others only a small effect. This effect of intervention is further evidence that "poor nutrition" contributes to poor intrauterine growth in selected mothers, even in developed countries.
|
https://pubmed.ncbi.nlm.nih.gov/6819029/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6819029
|
[
0.2291111797094345,
2.1746022701263428,
-1.5270332098007202,
-2.2457964420318604,
0.8966459035873413,
0.9206929802894592,
-0.8802868127822876,
-0.473909467458725,
-1.281903862953186,
-0.8723457455635071,
0.498043030500412,
2.224608898162842,
-0.010764669626951218,
0.07577977329492569,
-0.5160728096961975,
-1.2228331565856934,
-1.4332681894302368,
-0.07614601403474808,
0.07111627608537674,
-1.7045084238052368,
-0.49529629945755005,
0.08402816206216812,
-0.2736284136772156,
-0.3508293926715851,
0.49547794461250305,
-0.22537948191165924,
-0.11529352515935898,
1.0288745164871216,
-0.07249472290277481,
-0.26202914118766785,
1.473449468612671,
-0.7095924615859985,
-0.2439817637205124,
-0.15853102505207062,
0.6582339406013489,
0.042165569961071014,
1.5193520784378052,
-0.29175904393196106,
-0.5297592282295227,
0.45586416125297546,
0.512347400188446,
0.5532147884368896,
0.0315021350979805,
1.539275050163269,
1.0536307096481323,
-0.43463942408561707,
0.795017659664154,
-0.580664873123169,
-0.24430745840072632,
0.7217150330543518,
-0.4338879883289337,
0.656880795955658,
-0.7751843333244324,
-1.237108826637268,
1.4510879516601562,
0.1715017557144165,
0.6323776841163635,
-0.21581022441387177,
0.697621762752533,
-0.050973013043403625,
0.8715848326683044,
0.33905303478240967,
-0.5342594981193542,
0.41917306184768677,
-0.2551365792751312,
-1.1411330699920654,
0.6681953072547913,
0.2783794701099396,
-1.080216884613037,
1.238532543182373,
0.34648868441581726,
-0.2533159554004669,
-0.22690679132938385,
-1.2543556690216064,
1.0359019041061401,
1.0127311944961548,
0.3126944601535797,
1.2894726991653442,
-0.34147417545318604,
-0.10146952420473099,
-0.47718897461891174,
0.035937950015068054,
-0.14967142045497894,
0.7526848316192627,
-0.09540127217769623,
0.7907240986824036,
-1.360776424407959,
0.16698400676250458,
1.0766304731369019,
-1.4548503160476685,
-0.03472443297505379,
-0.7254688143730164,
-1.6202054023742676,
0.270807147026062,
0.04661555960774422,
0.6997187733650208,
-0.029984142631292343,
-0.18782395124435425,
0.25493836402893066,
-0.5089013576507568,
0.19001924991607666,
0.5431738495826721,
-0.9216989874839783,
0.6196985244750977,
-0.14701415598392487,
-0.5815820693969727,
-0.2600100338459015,
-0.18779297173023224,
-0.6127118468284607,
0.49162575602531433,
-0.09750958532094955,
-0.5527552962303162,
-0.8097310066223145,
-0.7500420212745667,
0.24772320687770844,
0.9406634569168091,
-0.3631466031074524,
-0.3788369596004486,
0.0817514955997467,
-0.9078457355499268,
0.6528515815734863,
-0.061005957424640656,
-0.45993489027023315,
0.7071835398674011,
-0.7648047208786011,
-0.09713264554738998,
0.3013257086277008,
0.14157499372959137,
-0.20844411849975586,
0.1721177101135254,
-0.47480517625808716,
0.7798937559127808,
1.1140366792678833,
-0.5213207006454468,
-0.3169064223766327,
-0.23146800696849823,
0.5503653287887573,
0.0377984493970871,
-0.3795487582683563,
-0.7500739097595215,
-0.5114263296127319,
0.11135713756084442,
-0.8202255964279175,
0.14537313580513,
-0.7287459373474121,
0.3883514404296875,
-0.33381134271621704,
-0.13790707290172577,
-0.32994788885116577,
0.3568981885910034,
-0.06971996277570724,
0.36102408170700073,
0.3778456747531891,
-0.23064614832401276,
-0.6497378945350647,
0.29792681336402893,
-0.16267646849155426,
-0.027299804612994194,
-0.25315454602241516,
-0.0902734100818634,
0.9650982618331909,
-0.38933277130126953,
0.0019203147385269403,
0.1321633756160736,
-0.10924442857503891,
0.3056449592113495,
0.25889766216278076,
-0.0010248745093122125,
0.11509398370981216,
-0.17263299226760864,
-0.023474806919693947,
0.21663010120391846,
-0.7182469367980957,
0.3146058917045593,
0.26089534163475037,
-0.07768156379461288,
0.764025092124939,
0.34975939989089966,
0.31464260816574097,
-0.045853495597839355,
-0.3526424765586853,
0.1244586929678917,
0.06932657957077026,
-0.17221961915493011,
-0.42433249950408936,
-0.08087184280157089,
0.27367183566093445,
-0.03253161162137985,
-0.3849099278450012,
0.15524178743362427,
0.46169397234916687,
0.43588775396347046,
-0.12671567499637604,
-0.3151075839996338,
-0.43773791193962097,
0.35524308681488037,
0.12727616727352142,
-0.22533848881721497,
0.40030714869499207,
0.19935961067676544,
-0.09311085194349289,
0.5927726626396179,
-0.4067346453666687,
0.21789966523647308,
-0.21144679188728333,
-0.11324644088745117,
-0.16370423138141632,
0.29677286744117737,
0.004904583096504211,
-0.1347000151872635,
0.5066153407096863,
0.41007199883461,
-0.07681768387556076,
0.6359482407569885,
-0.16364642977714539,
-0.09367968887090683,
-0.4320753514766693,
-0.12844832241535187,
-0.23744218051433563,
0.06450105458498001,
0.18752209842205048,
-0.09402314573526382,
-0.504541277885437,
-0.524463415145874,
0.3811013698577881,
0.24410764873027802,
-0.07042979449033737,
0.11302702873945236,
0.03126251697540283,
0.11585595458745956,
0.17011991143226624,
-0.27355289459228516,
-0.11644355952739716,
-0.16406089067459106,
-0.025910397991538048,
0.12153733521699905,
-0.2861892879009247,
0.2455732226371765,
0.10236620903015137,
-0.1974315196275711,
-0.38664519786834717,
-0.6178934574127197,
0.15686443448066711,
0.006638445891439915,
-0.045801080763339996,
-0.14004535973072052,
0.04627963528037071,
0.24402499198913574,
-0.03374301269650459,
-0.6344537734985352,
0.24609552323818207,
0.3772090971469879,
0.1149597316980362,
0.09315444529056549,
0.2981252074241638,
-0.14407430589199066
] |
6,819,274 |
The European experience in neutron therapy at the end of 1981.
|
Wambersie A A
|
International journal of radiation oncology, biology, physics . Vol. 8, No. 12, 1982 Dec
|
We present here a survey of the European neutron therapy facilities. For head and neck tumors, the excellent results reported from Hammersmith were not confirmed by an EORTC combined trial (Amsterdam, Edinburgh and Essen). For salivary glands, high percentages (75%) of local control were obtained in Hammersmith and in Amsterdam, as well as in other centers. Following the promising results reported from Hammersmith, neutron therapy of soft tissue sarcomas was started in several centers. For patients with no clinical evidence of residual tumor after surgery, a local control rate ranging between 70% and 90% was achieved (Essen, Hamburg, Heidelberg, Louvain-la-Neuve). For patients with "gross" residual tumor, or with inoperable tumors, the percentages of local control vary within large limits (20-75%) from center to center, probably according to differences in histology, tumor localization, tumor size or extention, and perhaps fractionation (Hammersmith, Edinburg, Amsterdam, Essen, Hamburg, Heidelberg, Louvain-la-Neuve). A study on bronchus carcinoma, performed in Heidelberg, did not show any benefit with neutron therapy. Patients with locally extended cervix and prostate carcinoma were treated in Louvain-la-Neuve according to the RTOG protocol; an excellent early tolerance was noticed. However, for both sites, it is too early to derive valid long term conclusions. For prostatic tumors, a complete regression is usually achieved. For bladder carcinoma, the results from Manchester did not indicate a significant difference between neutron and photon therapy, both in initial assessment of results and complications. The Amsterdam group came to similar conclusions.
|
https://pubmed.ncbi.nlm.nih.gov/6819274/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article"
] |
6819274
|
[
1.3175584077835083,
2.2281527519226074,
-0.7094417214393616,
-0.19614537060260773,
-0.8439198136329651,
1.1649149656295776,
-0.2228136658668518,
-0.4286274313926697,
-1.084695816040039,
0.37661731243133545,
-0.28084132075309753,
0.305220365524292,
-1.0721505880355835,
-0.3097074329853058,
-0.8338167667388916,
-0.06482823938131332,
-0.5779565572738647,
0.9524427652359009,
-0.04674357920885086,
-0.7097463011741638,
-0.27897053956985474,
-0.3842264413833618,
-0.46397271752357483,
-0.23161587119102478,
0.5395956039428711,
-0.6850311160087585,
0.24431325495243073,
-0.3796081244945526,
-0.02850824035704136,
0.7991783618927002,
-0.42651012539863586,
0.060804106295108795,
-0.20659278333187103,
0.0073457262478768826,
-0.420371413230896,
-0.524039089679718,
0.9831889271736145,
-0.18583565950393677,
-0.1877964287996292,
-0.1094517856836319,
0.7945643067359924,
-0.0789186954498291,
-0.417330801486969,
-0.4644046127796173,
0.718586802482605,
0.684049665927887,
-0.6749664545059204,
-0.24628400802612305,
0.7444742321968079,
-0.023569781333208084,
-0.34691736102104187,
0.5863269567489624,
-1.203576683998108,
0.0677499994635582,
1.0283876657485962,
0.12081687152385712,
-0.042090028524398804,
0.8780547380447388,
0.6923710703849792,
-0.4684370756149292,
0.3555936813354492,
-0.0849091187119484,
0.7791488170623779,
0.30564093589782715,
-0.608955442905426,
-0.18238092958927155,
0.2518959641456604,
0.5845386981964111,
0.010541186667978764,
0.4520278573036194,
0.20932939648628235,
-0.21600781381130219,
0.0708465501666069,
-0.06785258650779724,
0.7777279019355774,
0.11619459837675095,
0.11260607838630676,
0.01115022599697113,
0.7879749536514282,
0.6037872433662415,
-0.2535741627216339,
-0.8855624794960022,
-0.47026267647743225,
0.06511887162923813,
-0.0024205297231674194,
-0.9159658551216125,
-0.9116687774658203,
-1.173244833946228,
0.273351788520813,
-0.8836870789527893,
-0.2492922842502594,
-0.1062784194946289,
-0.7235329747200012,
-0.17453940212726593,
-0.8672449588775635,
0.1841427981853485,
-0.36361637711524963,
-0.8517988324165344,
0.17564783990383148,
-0.21922452747821808,
0.27666813135147095,
0.5999789237976074,
-0.3830682337284088,
-0.528814971446991,
-1.0241203308105469,
-0.8588640093803406,
-0.44951194524765015,
-0.6574386954307556,
-0.007455805782228708,
-0.43534111976623535,
0.3889590799808502,
-0.5285953879356384,
0.10726785659790039,
-0.2574062943458557,
0.009930095635354519,
-0.31846046447753906,
0.5879126787185669,
-0.0802735760807991,
0.6296566724777222,
-0.2599659264087677,
-0.035996630787849426,
-0.14441199600696564,
-0.3349612355232239,
0.498311311006546,
-0.15499895811080933,
0.07362319529056549,
-0.19514583051204681,
0.5356334447860718,
-0.7147907614707947,
-0.9782280325889587,
-0.15124660730361938,
0.21764028072357178,
0.06190691143274307,
-0.3925543427467346,
-0.8642128705978394,
-0.32125991582870483,
-0.38260704278945923,
0.8926902413368225,
0.42247092723846436,
-0.6580614447593689,
-0.07064129412174225,
0.38049525022506714,
0.00962405651807785,
0.479351669549942,
-0.5486530065536499,
0.0556207112967968,
-0.3427373766899109,
0.25863292813301086,
-0.4471050500869751,
-0.016532577574253082,
0.2032657116651535,
0.024065479636192322,
0.07186480611562729,
0.4712904393672943,
-0.23661674559116364,
0.5053809881210327,
0.06961101293563843,
0.3150743246078491,
-0.48145240545272827,
-0.7174994349479675,
-0.02625856176018715,
-0.5324355959892273,
-0.08665277063846588,
-0.8888978362083435,
0.6238352060317993,
-0.9375250339508057,
-0.44074541330337524,
-0.3465726673603058,
-0.48673513531684875,
0.09007889777421951,
-0.6540223956108093,
-0.2553725242614746,
0.48985588550567627,
0.9312475919723511,
-0.16381575167179108,
-0.09736679494380951,
0.4505488872528076,
-0.315406858921051,
0.8787276744842529,
-0.179536372423172,
-0.16829515993595123,
0.005096093751490116,
0.2325400710105896,
-0.4144389033317566,
0.09263379126787186,
0.3003133535385132,
-0.008270869962871075,
-0.38321390748023987,
0.06039128080010414,
0.15994752943515778,
-0.18180982768535614,
-0.00016227178275585175,
0.1347644180059433,
0.09312836825847626,
0.5084694623947144,
-0.31772303581237793,
-0.4338701665401459,
-0.20558418333530426,
0.5779522657394409,
0.07861367613077164,
-0.4763632118701935,
0.05092747509479523,
-0.2762645184993744,
0.05390371009707451,
-0.040073443204164505,
-0.14362603425979614,
-0.15441231429576874,
0.05998913198709488,
-0.4404025673866272,
0.3340798020362854,
-0.12554654479026794,
0.3699227273464203,
0.24705232679843903,
0.04282533377408981,
0.06640009582042694,
0.5273159146308899,
0.08251233398914337,
-0.0767965242266655,
-1.1730035543441772,
-0.18204742670059204,
-0.23388387262821198,
0.24641193449497223,
-0.2792084217071533,
-0.2134488821029663,
-0.03444798290729523,
-0.12711746990680695,
-0.07091105729341507,
-0.10641610622406006,
0.4869045615196228,
-0.016431601718068123,
-0.40964773297309875,
0.24950742721557617,
0.15813757479190826,
-0.1736382097005844,
-0.401810884475708,
-0.20935553312301636,
-0.010478269308805466,
-0.11131882667541504,
0.173533633351326,
0.2972995936870575,
0.3404707908630371,
-0.5733029246330261,
-0.1311461180448532,
-0.09061113744974136,
-0.15401476621627808,
0.2686931788921356,
-0.11833097785711288,
-0.4228038489818573,
0.3129580616950989,
-0.2636968493461609,
0.17050801217556,
-0.10132715851068497,
0.0937512218952179,
0.20349523425102234,
-0.048893433064222336,
-0.15720415115356445
] |
6,819,276 |
Results of d + T fast neutron irradiation on advanced tumors of bladder and rectum.
|
Battermann J J JJ
|
International journal of radiation oncology, biology, physics . Vol. 8, No. 12, 1982 Dec
|
From November, 1975 to November, 1981, around 400 patients were irradiated with 14 MeV d + T fast neutrons at the Antoni van Leeuwenhoek Hospital in Amsterdam. Special interest was focused on inoperable tumors of bladder and rectum. During the pilot phase of the study 47 patients were treated, mostly via two parallel opposed ports with dosages that ranged from 18 to more than 22 Gy. Although persistent local control was achieved in 23 patients (48%), 14 patients (29%) died of severe complications. By the introduction of a six field technique, the fatal complication rate could be reduced significantly. Since May 1978 patients were randomized in a three arm trial, using two dose levels on the neutron site. The preliminary results of a group of 91 patients show a similar survival in the three treatment arms with a somewhat better local control rate for high dose neutrons. An attempt was made to estimate RBE values for tumor control and normal tissue reactions by comparing the data for neutron irradiation with the data obtained with photons on a similar group of patients. From the values derived it must be concluded that the gain for neutron irradiation on these tumors in the pelvis will be negligible.
|
https://pubmed.ncbi.nlm.nih.gov/6819276/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6819276
|
[
0.43287980556488037,
1.9533532857894897,
-0.19288086891174316,
-1.739100694656372,
0.5131341814994812,
0.7446627020835876,
-0.06551709026098251,
-0.7193722128868103,
-1.0576304197311401,
0.5052029490470886,
-1.9110820293426514,
1.5414305925369263,
-1.1002984046936035,
0.2911548316478729,
-0.39755168557167053,
0.12791666388511658,
-1.18486750125885,
-0.14224107563495636,
-0.028171999379992485,
-1.462322473526001,
-0.5943443775177002,
0.45443394780158997,
-0.3843233585357666,
0.5342002511024475,
0.16318896412849426,
-0.9123028516769409,
-0.9809642434120178,
0.2760782837867737,
0.7924337983131409,
0.25242504477500916,
-0.2926332950592041,
0.07210638374090195,
0.14064952731132507,
0.49793824553489685,
0.2844105660915375,
-0.3331969976425171,
1.0708754062652588,
0.047988664358854294,
0.2094564586877823,
0.35100066661834717,
0.9688950777053833,
0.1051625907421112,
-0.2999313771724701,
-0.24252794682979584,
0.9410717487335205,
0.3602712154388428,
0.05309414863586426,
-0.14086806774139404,
0.10446367412805557,
-0.2582832872867584,
-0.6314879655838013,
0.8926446437835693,
-0.7266719937324524,
0.18080009520053864,
1.0695953369140625,
0.5448524355888367,
-0.051546912640333176,
0.24868498742580414,
1.174294352531433,
-0.15785758197307587,
0.1761482208967209,
0.5445734262466431,
0.17574679851531982,
-0.10253115743398666,
-0.22417812049388885,
-0.8835711479187012,
0.48157358169555664,
0.3530968129634857,
-0.0026901860255748034,
0.5872105360031128,
-0.5666998028755188,
0.08745069056749344,
0.19634966552257538,
0.20656126737594604,
0.8687584400177002,
0.27334675192832947,
-0.24760328233242035,
-0.12187168002128601,
0.5456319451332092,
0.331347793340683,
-0.46762266755104065,
-0.9444357752799988,
-0.08985234051942825,
0.9137032628059387,
0.49020835757255554,
0.17014247179031372,
-0.6550998091697693,
-0.07488413900136948,
0.11205137521028519,
-0.3146522343158722,
-0.12254012376070023,
-0.43994128704071045,
-1.5743156671524048,
0.29927343130111694,
-0.7255979180335999,
-0.17392483353614807,
-0.15995250642299652,
-0.29125699400901794,
-0.3959904909133911,
-0.3732065260410309,
0.09137528389692307,
0.4542701542377472,
-0.2611859142780304,
0.04791920259594917,
-0.6148753762245178,
-0.6137235760688782,
-0.2786802351474762,
-0.37055134773254395,
-0.2913268804550171,
-0.4608761966228485,
0.4832589030265808,
-0.6196827292442322,
0.1967955082654953,
-0.5789976716041565,
0.14997361600399017,
0.28463855385780334,
0.31095436215400696,
-0.3559778928756714,
0.0001439912593923509,
-0.1609211415052414,
0.24600055813789368,
-0.10514328628778458,
-0.08255340903997421,
0.4262152910232544,
-0.0034343809820711613,
-0.2862432897090912,
0.031763944774866104,
0.24131545424461365,
-0.20960745215415955,
-0.5294937491416931,
-0.2770908772945404,
0.3049895167350769,
-0.13477444648742676,
-0.5220606327056885,
-0.5647274851799011,
-0.17807011306285858,
0.1551843136548996,
1.456638216972351,
0.38328230381011963,
-0.2848382592201233,
0.00578400818631053,
0.5958713889122009,
-0.2230166792869568,
0.35816946625709534,
-0.8102693557739258,
-0.08282050490379333,
-0.33394312858581543,
0.415740966796875,
-0.5297255516052246,
-0.13951171934604645,
0.12857837975025177,
0.1321188509464264,
-0.1877746284008026,
0.15125685930252075,
-0.30872777104377747,
0.5150931477546692,
0.4264656603336334,
0.06629224121570587,
-0.42755842208862305,
-0.22519680857658386,
-0.1919861137866974,
-0.9074552059173584,
-0.14093232154846191,
-0.5368211269378662,
0.8453816175460815,
-0.11606369912624359,
-0.2910420298576355,
-0.30539172887802124,
0.13781453669071198,
0.17130686342716217,
-0.4400280714035034,
0.08433251082897186,
0.31535014510154724,
0.4884684979915619,
-0.06610739976167679,
-0.09959253668785095,
0.5086992383003235,
0.3382522165775299,
0.7679525017738342,
0.030611885711550713,
-0.12490241229534149,
-0.17920486629009247,
0.09695944935083389,
-0.14242617785930634,
-0.22138583660125732,
0.1386396437883377,
0.07753781974315643,
-0.16161760687828064,
0.22570163011550903,
-0.39975816011428833,
0.10748415440320969,
0.061974577605724335,
0.20936037600040436,
0.48349708318710327,
0.3942359685897827,
-0.296477735042572,
-0.29859787225723267,
-0.37064293026924133,
0.2979671359062195,
-0.09727757424116135,
-0.39530178904533386,
-0.10069019347429276,
-0.30399060249328613,
0.041517700999975204,
-0.21643656492233276,
-0.012654813006520271,
-0.09425140172243118,
-0.04382557049393654,
-0.3261859714984894,
0.33378779888153076,
-0.04433542117476463,
-0.0009606592357158661,
-0.03989298269152641,
-0.2081838697195053,
-0.025179188698530197,
0.15564458072185516,
0.270030677318573,
-0.011427225545048714,
-0.8528968691825867,
-0.2945418059825897,
0.16204281151294708,
-0.16710522770881653,
0.07961256802082062,
-0.08099246770143509,
-0.15784889459609985,
-0.3187107741832733,
0.04744839668273926,
-0.3876858055591583,
0.30981290340423584,
-0.19391308724880219,
-0.23382903635501862,
-0.17693309485912323,
0.0987946093082428,
0.12740470468997955,
0.012318692170083523,
-0.05824648216366768,
0.07991603016853333,
-0.03602560982108116,
-0.05252242088317871,
0.4835236966609955,
0.28737127780914307,
-0.25069087743759155,
-0.04119453579187393,
-0.4034138023853302,
0.014393729157745838,
0.28171995282173157,
0.2203674614429474,
-0.009377536363899708,
0.14002209901809692,
0.1481999009847641,
0.28094029426574707,
0.04709073528647423,
0.11374736577272415,
-0.019084949046373367,
-0.07688917219638824,
-0.23167555034160614
] |
6,819,277 |
Absence of a demonstrable gain factor for neutron beam therapy of epidermoid carcinoma of the head and neck.
|
Cohen L L
|
International journal of radiation oncology, biology, physics . Vol. 8, No. 12, 1982 Dec
|
A comparison of normal tissue and tumor responses in patients treated with the high energy Fermilab neutron beam and conventional photons (Cobalt and 4 MeV X rays), yielded the following parameters. For neutrons the median dose for significant radiation injury in the irradiated tissues was 31 (+2) Gy and the median dose for local control of the tumor was 26 (+2) Gy. The corresponding doses for photons were 90 (+4) Gy for normal tissue injury and 74 (+3) Gy for local control of the tumor. These figures show that the therapeutic ratio is roughly 1.2 for both neutrons and photons. Similarly, the RBE of neutrons relative to photons is about the same for normal tissue tolerance and for tumor control. Under these conditions, there is no demonstrable therapeutic gain factor for neutrons relative to photons. The overall local control rate was the same for both modalities (44%).
|
https://pubmed.ncbi.nlm.nih.gov/6819277/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Research Support, U.S. Gov't, P.H.S."
] |
6819277
|
[
0.5224043726921082,
1.1165229082107544,
-1.5037189722061157,
-2.1902172565460205,
-0.08921696990728378,
1.1073801517486572,
-0.41583451628685,
-1.067337989807129,
-1.4271498918533325,
-0.4681369662284851,
-1.135457992553711,
1.6640934944152832,
-1.3720355033874512,
-0.537510335445404,
-0.6314105987548828,
0.6081100106239319,
-1.191771149635315,
0.5434526801109314,
-0.05990218743681908,
-2.1908421516418457,
-1.5875165462493896,
-0.31878864765167236,
0.17977389693260193,
0.5965018272399902,
1.39150071144104,
-0.9489304423332214,
-0.6377844214439392,
0.7219302654266357,
0.34448885917663574,
-0.47872668504714966,
-0.3961358368396759,
-0.03306266665458679,
0.13283629715442657,
0.25360286235809326,
0.3214379847049713,
-0.09188617765903473,
1.3608986139297485,
-0.14857588708400726,
0.8596818447113037,
0.41779646277427673,
1.2282871007919312,
0.626350998878479,
0.4511108100414276,
-0.322713166475296,
-0.10546614974737167,
-0.18144163489341736,
-0.322876513004303,
-0.5568751692771912,
-0.739041805267334,
0.023106003180146217,
-0.7109822630882263,
1.1292448043823242,
-0.06310012936592102,
0.24560856819152832,
2.128830909729004,
0.27001944184303284,
0.5477543473243713,
0.46777838468551636,
0.9069772958755493,
-0.00989254005253315,
0.19577135145664215,
0.845827043056488,
0.36581283807754517,
-0.6258594989776611,
-0.42855873703956604,
-0.7660366892814636,
0.8308749794960022,
-0.2636098265647888,
-0.24017389118671417,
0.9146437644958496,
-0.4395386278629303,
0.1281469166278839,
0.23632867634296417,
0.722814679145813,
0.825477659702301,
-0.19404421746730804,
-0.728877067565918,
-0.10892333090305328,
0.6208852529525757,
0.22948846220970154,
0.16622649133205414,
-1.5827668905258179,
-0.9287878274917603,
0.888294517993927,
0.06510995328426361,
0.42000696063041687,
-0.2455758899450302,
-0.12614910304546356,
0.37548431754112244,
-0.29529762268066406,
0.5389243364334106,
-0.14453235268592834,
-1.5301015377044678,
1.1288444995880127,
-1.0539902448654175,
-0.039366357028484344,
-0.2775363624095917,
0.2170310914516449,
0.24701790511608124,
0.2077467441558838,
-0.005773141980171204,
0.6386430859565735,
-0.5785653591156006,
-0.29656752943992615,
-0.5098865628242493,
-0.35982218384742737,
-0.49692174792289734,
-0.2530626654624939,
-0.35907870531082153,
-0.5711334943771362,
0.4482487440109253,
-0.9936615228652954,
-0.2543818950653076,
-1.178969144821167,
0.6559793949127197,
0.24020102620124817,
-0.2372630387544632,
0.27033665776252747,
-0.10064276307821274,
-0.21092920005321503,
0.15475748479366302,
0.1563343107700348,
-0.34852975606918335,
0.19317995011806488,
0.32293596863746643,
-0.4446861147880554,
0.19484922289848328,
-0.14663420617580414,
-0.08061033487319946,
-1.3382182121276855,
-0.3129687011241913,
0.5633363723754883,
0.017260493710637093,
-0.13715550303459167,
-0.7708054780960083,
-0.6193389296531677,
0.056396130472421646,
0.4960850477218628,
0.9257404804229736,
-0.023454224690794945,
0.3239116966724396,
0.3405729830265045,
-0.41406479477882385,
-0.09037599712610245,
-0.49512094259262085,
-0.0854531079530716,
-0.19215728342533112,
0.9001495242118835,
-0.39926284551620483,
0.17693328857421875,
0.277921587228775,
-0.15395109355449677,
-0.03243129327893257,
0.4935295581817627,
-0.577627956867218,
0.766790509223938,
-0.027245912700891495,
0.393833726644516,
-0.6977699398994446,
-0.0586404986679554,
-0.3900003135204315,
0.10621190816164017,
-0.10095173865556717,
-0.15409745275974274,
1.1633715629577637,
0.02506820484995842,
-0.7578238248825073,
-0.2583937644958496,
-0.27569636702537537,
-0.1712949424982071,
0.04074352979660034,
-0.3723313510417938,
0.4235674738883972,
1.2050143480300903,
0.15212321281433105,
0.28630709648132324,
0.20975664258003235,
-0.004128560423851013,
1.0614159107208252,
-0.11384555697441101,
-0.5250322222709656,
0.5842692852020264,
0.37921783328056335,
-0.40995532274246216,
0.059391770511865616,
0.004586376715451479,
0.3561631143093109,
-0.10781752318143845,
-0.09377454966306686,
0.09412963688373566,
0.06416979432106018,
0.32981693744659424,
0.17175902426242828,
0.4540574848651886,
0.5214291214942932,
0.009894205257296562,
-0.9214829206466675,
-0.057720888406038284,
0.2330358326435089,
0.08075784891843796,
-0.6640834808349609,
0.2050171047449112,
-0.3306511342525482,
0.17266671359539032,
-0.014460376463830471,
-0.16354776918888092,
-0.09493017941713333,
0.22071632742881775,
-0.2777223587036133,
0.41677290201187134,
-0.12746070325374603,
0.32246482372283936,
0.13681259751319885,
-0.15170253813266754,
0.022257011383771896,
0.06607072800397873,
0.37883180379867554,
0.019077736884355545,
-0.9621607065200806,
-0.3909272253513336,
-0.23904132843017578,
0.27320224046707153,
0.19075167179107666,
0.04226252809166908,
0.015472792088985443,
-0.06687971949577332,
0.22674763202667236,
-0.46868616342544556,
-0.08331720530986786,
-0.5957490801811218,
-0.3703388571739197,
0.046403951942920685,
-0.16457988321781158,
-0.02459106035530567,
-0.21004143357276917,
-0.17818044126033783,
-0.21652308106422424,
-0.21375063061714172,
0.18743441998958588,
0.36334386467933655,
0.46696388721466064,
-0.1300608217716217,
-0.35802939534187317,
0.06560007482767105,
0.35912927985191345,
0.11020470410585403,
0.026702847331762314,
-0.2548277676105499,
-0.1914202868938446,
-0.1696377545595169,
0.15483510494232178,
-0.2216138392686844,
0.37074702978134155,
0.31334155797958374,
-0.5313397645950317,
-0.03686200827360153
] |
6,819,279 |
Treatment of cancer with heavy charged particles.
|
Castro J R JR, Saunders W M WM, Tobias C A CA, Chen G T GT, Curtis S S, Lyman J T JT, Collier J M JM, Pitluck S S, Woodruff K A KA, Blakely E A EA, Tenforde T T, Char D D, Phillips T L TL, Alpen E L EL
|
International journal of radiation oncology, biology, physics . Vol. 8, No. 12, 1982 Dec
|
A clinical radiotherapeutic trial using heavy charged particles in the treatment of human cancers has accrued over 400 patients since 1975, 378 of whom were treated with particles and 28 with low LET photons as control patients. Heavy charged particle radiotherapy offers the potential advantages of improved dose localization and/or enhanced biologic effect, depending on particle selected for treatment. Target sites have included selected head and neck tumors, ocular melanomata, malignant gliomata of the brain, carcinoma of the esophagus, carcinoma of the stomach, carcinoma of the pancreas, selected juxtaspinal tumors and other locally advanced, unresectable tumors. A Phase III prospective clinical trial has been started in carcinoma of the pancreas using helium ions. Phase I-II studies are underway with heavier particles such as carbon, neon and argon ions in order to prepare for prospective Phase III trials. Silicon ions are also under consideration for clinical trial. These studies are supported by the United States Department of Energy and National Institutes of Health.
|
https://pubmed.ncbi.nlm.nih.gov/6819279/
|
[
"Clinical Trial",
"Journal Article",
"Research Support, U.S. Gov't, Non-P.H.S.",
"Research Support, U.S. Gov't, P.H.S."
] |
6819279
|
[
1.9788880348205566,
2.0583465099334717,
-1.5119171142578125,
-1.8436450958251953,
-0.4429561197757721,
0.4893445074558258,
-0.8788788318634033,
-1.7520062923431396,
-1.4241464138031006,
0.02526155672967434,
-0.12195394188165665,
0.6154628396034241,
-0.3490052819252014,
0.5572647452354431,
0.2932385206222534,
0.4583936333656311,
-0.3587254285812378,
1.35335111618042,
1.557466983795166,
-1.2034181356430054,
0.39932626485824585,
-0.8642488121986389,
-0.7495479583740234,
0.7046886086463928,
0.30155980587005615,
-1.054813027381897,
-1.2338919639587402,
1.1592724323272705,
1.4574368000030518,
1.0789463520050049,
-0.7973719239234924,
0.18637588620185852,
-0.11478255689144135,
-0.06539931148290634,
-0.32787686586380005,
-0.010747364722192287,
1.4496371746063232,
0.9518239498138428,
-0.9023357033729553,
-0.3245026469230652,
-0.885679304599762,
0.3731871545314789,
0.003436878090724349,
-0.3078409731388092,
0.4382990598678589,
-0.9107468724250793,
-0.9596328735351562,
-0.34166646003723145,
1.028620958328247,
0.07716113328933716,
-0.415689080953598,
0.6843932271003723,
-0.5315880179405212,
0.4504794776439667,
1.0151464939117432,
-0.025524036958813667,
-0.49808943271636963,
0.7526796460151672,
2.1707136631011963,
0.4115630090236664,
0.7895873188972473,
0.09353127330541611,
-0.12079057842493057,
0.7942189574241638,
-0.6373646259307861,
-0.45567700266838074,
-0.25483205914497375,
-0.7402550578117371,
0.08657550811767578,
-0.05849171057343483,
-0.05756290256977081,
0.36311647295951843,
0.5352234244346619,
-0.7112998366355896,
0.9840784072875977,
0.18802271783351898,
0.3518419563770294,
-0.608056366443634,
0.4683789014816284,
-0.6052843928337097,
-0.4734724164009094,
0.12264994531869888,
-0.3111996650695801,
0.263010174036026,
0.06895124167203903,
-0.2346692681312561,
-0.3967461884021759,
-0.9741312861442566,
0.18204058706760406,
-1.1229041814804077,
0.05449552461504936,
0.0032924951519817114,
-1.26570463180542,
0.61832195520401,
-0.7475704550743103,
-0.4047142565250397,
0.3794613778591156,
-0.15313395857810974,
-0.09689731150865555,
-0.3242934048175812,
0.5101653933525085,
0.4548793435096741,
-0.7489035725593567,
-0.23407813906669617,
-1.2390384674072266,
-0.2731902599334717,
0.18125306069850922,
-0.1799089014530182,
-0.4854758083820343,
-0.6167665719985962,
0.6224080920219421,
-0.528477668762207,
-0.13046368956565857,
-0.6067468523979187,
-0.04010384529829025,
0.14259712398052216,
1.0803587436676025,
0.03378874436020851,
-0.1459808498620987,
-0.4105836749076843,
0.07199937105178833,
0.3825921416282654,
-0.5556365251541138,
-0.17700007557868958,
0.184589684009552,
0.20399276912212372,
-0.7795804738998413,
-0.1937960684299469,
0.30700427293777466,
-1.4713003635406494,
-0.26934120059013367,
0.3970588445663452,
0.6526886820793152,
-0.6081408858299255,
-0.6869476437568665,
-0.6259248852729797,
0.24496586620807648,
1.0562173128128052,
0.35304516553878784,
-0.31034770607948303,
0.1491997390985489,
0.3837941288948059,
0.3074686527252197,
0.4345627427101135,
-1.4267637729644775,
-0.7847002744674683,
0.3431849777698517,
0.3212257921695709,
-0.4936263859272003,
-0.10006368160247803,
-0.8040178418159485,
0.053975366055965424,
-0.2716016471385956,
0.471843421459198,
0.24134911596775055,
0.6976447701454163,
0.4462191164493561,
-0.16267934441566467,
-0.024017879739403725,
-0.2710711359977722,
-0.8895836472511292,
-0.2535056471824646,
0.2420283406972885,
-0.47355005145072937,
0.8991547226905823,
0.04547521844506264,
-0.608318030834198,
-0.4046633541584015,
0.06111254170536995,
0.038705483078956604,
-0.30221474170684814,
-0.38293683528900146,
0.35366371273994446,
0.3849110007286072,
-0.5531670451164246,
0.08861923962831497,
0.4402947723865509,
-0.15494200587272644,
0.8423686623573303,
-0.5176335573196411,
-0.6665077805519104,
0.2063923329114914,
0.45405077934265137,
-0.4026859402656555,
-0.06670521199703217,
0.2658797800540924,
0.5251908898353577,
0.5728898644447327,
0.0443643294274807,
0.29863765835762024,
0.6715677380561829,
-0.1370345950126648,
-0.15361662209033966,
0.15330952405929565,
0.11528830230236053,
-0.06549166142940521,
-0.335286021232605,
0.17471042275428772,
0.47717657685279846,
0.09688147902488708,
0.3231721520423889,
0.11564428359270096,
-0.28774023056030273,
-0.05750008299946785,
0.023347845301032066,
-0.22190499305725098,
-0.367831826210022,
-0.001988557633012533,
-0.19697758555412292,
0.32114923000335693,
-0.46178922057151794,
0.1584632843732834,
0.4455620050430298,
0.12038075923919678,
0.1423044055700302,
-0.26482266187667847,
0.28629520535469055,
0.33768656849861145,
-1.0147044658660889,
-0.47121837735176086,
-0.1398569792509079,
0.1702280193567276,
-0.3319316804409027,
0.1806313395500183,
-0.12784089148044586,
0.112757608294487,
-0.1389152556657791,
0.06371133029460907,
0.2552652359008789,
-0.145562544465065,
-0.6605767607688904,
-0.046829480677843094,
0.3839181065559387,
-0.0705292746424675,
0.17456074059009552,
-0.24071064591407776,
-0.3711434304714203,
0.1196792721748352,
0.01818280667066574,
0.26035255193710327,
0.44929519295692444,
-0.44473689794540405,
-0.266312837600708,
-0.6154118180274963,
-0.49443307518959045,
0.030988702550530434,
0.18979106843471527,
-0.269374817609787,
0.03346805274486542,
0.056775983422994614,
-0.01708650402724743,
0.15407295525074005,
0.048147063702344894,
0.40269601345062256,
-0.24879351258277893,
-0.37791863083839417
] |
6,819,339 |
A comparison of phenytoin and pheneturide in patients with epilepsy: a double-blind cross-over trial.
|
Gibberd F B FB, Park D M DM, Scott G G, Gawel M J MJ, Fry D E DE, Page N G NG, Engler C C, English J R JR, Rose F C FC
|
Journal of neurology, neurosurgery, and psychiatry . Vol. 45, No. 12, 1982 Dec
|
A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described. There was no significant difference between the frequency of seizures in the two groups. The difficulties in comparing two anticonvulsants of similar efficacy are discussed particularly in relation to ethical problems, the selection of patients and trial design.
|
https://pubmed.ncbi.nlm.nih.gov/6819339/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article"
] |
6819339
|
[
-0.334257036447525,
1.652735948562622,
-2.145298957824707,
-0.4195302426815033,
-0.995959997177124,
-0.2861166000366211,
-0.26315510272979736,
-0.6572974324226379,
-0.9809494018554688,
1.4146549701690674,
0.44654548168182373,
2.1203572750091553,
-1.6616829633712769,
0.10194100439548492,
0.4548965096473694,
0.6022207736968994,
-0.09501110017299652,
-1.364124059677124,
0.1083894670009613,
-2.650933265686035,
-0.17525415122509003,
2.297128438949585,
-0.5889468789100647,
-0.6567105054855347,
-0.731743335723877,
-0.2786710560321808,
-1.1409765481948853,
1.8972440958023071,
0.058515869081020355,
0.6541041731834412,
1.1848722696304321,
-0.019233213737607002,
0.9674040675163269,
-0.053630612790584564,
-0.14165547490119934,
-0.043334681540727615,
-0.2829618453979492,
-0.014430665411055088,
-0.15906065702438354,
-0.4837302565574646,
0.960919976234436,
0.31165963411331177,
-0.014322957023978233,
-0.3393160104751587,
0.7528783082962036,
0.522180438041687,
0.25670379400253296,
0.22001273930072784,
-1.1371062994003296,
0.3865932822227478,
-0.7273635268211365,
1.2739665508270264,
-0.010000214911997318,
0.890957236289978,
1.1741341352462769,
0.9644591808319092,
0.13169622421264648,
1.2537604570388794,
0.9981446862220764,
-0.4316790699958801,
1.1866068840026855,
-0.38940057158470154,
0.5403426289558411,
0.012908212840557098,
-0.6463169455528259,
0.8538405895233154,
0.29521891474723816,
-1.7848619222640991,
-1.3321452140808105,
0.3441336750984192,
-1.4062025547027588,
-0.02683258056640625,
0.6486817598342896,
-0.4704171121120453,
0.8411509394645691,
0.0202651247382164,
-0.4063756465911865,
0.19016264379024506,
1.8126630783081055,
1.1766691207885742,
-0.31671804189682007,
-0.3823482096195221,
-0.49427229166030884,
-0.741439700126648,
-0.35679981112480164,
-0.020829936489462852,
-0.6219691634178162,
-0.6144649386405945,
-0.1509401947259903,
-1.2145154476165771,
0.6533797383308411,
-0.32622745633125305,
-0.9940524697303772,
0.16791726648807526,
-0.0609159953892231,
-0.013989509083330631,
-0.4255615770816803,
-0.07887992262840271,
-0.17092524468898773,
-0.06129993125796318,
0.022943127900362015,
0.45986154675483704,
-0.2127590924501419,
-0.5680634379386902,
-0.3963518738746643,
-0.3710668683052063,
-0.44491127133369446,
-0.8718667030334473,
-0.7090730667114258,
-0.9490580558776855,
0.14108838140964508,
0.6922746896743774,
-0.3647761940956116,
-0.11891628801822662,
0.6577700972557068,
0.48007455468177795,
0.7394978404045105,
-0.7424356937408447,
-0.9394646286964417,
0.10635416954755783,
0.26433873176574707,
0.6477580070495605,
1.0442519187927246,
0.46655476093292236,
-0.5007613301277161,
0.639970600605011,
-0.22561600804328918,
0.21891160309314728,
-1.011616826057434,
0.32499995827674866,
-0.04811706021428108,
0.575141191482544,
0.05357689782977104,
-0.4302826523780823,
-0.7979711294174194,
-0.40600377321243286,
1.001875400543213,
1.3381242752075195,
0.14537030458450317,
-0.8536321520805359,
-0.09993230551481247,
0.7002293467521667,
0.23050615191459656,
-0.01899689808487892,
-0.3239096999168396,
-0.026394398882985115,
-0.3096923828125,
0.3222266733646393,
-0.4116741418838501,
-0.09850827604532242,
-0.2312861531972885,
0.8533645272254944,
0.45740583539009094,
-0.7084344029426575,
0.12115052342414856,
0.48746851086616516,
0.4086361527442932,
-0.35702425241470337,
0.21613286435604095,
0.8978138566017151,
-0.1948089897632599,
-0.5950545072555542,
0.3984118103981018,
0.013879766687750816,
-0.2829465866088867,
0.14395219087600708,
-0.36769309639930725,
0.3113710582256317,
0.05013654753565788,
0.2252497673034668,
-0.5619723200798035,
0.26481151580810547,
0.3600429594516754,
0.7094721794128418,
0.4303573966026306,
0.046431321650743484,
0.6160818934440613,
0.07149752229452133,
0.6000891923904419,
0.0631072148680687,
0.06694960594177246,
-0.42501088976860046,
-0.4292588531970978,
0.07153378427028656,
0.056784488260746,
-0.5727239847183228,
-0.7787330150604248,
-0.6382426023483276,
0.2892194092273712,
-0.05539122596383095,
0.09127781540155411,
-0.3334585428237915,
0.2883903980255127,
-0.676796019077301,
0.22530674934387207,
-0.2514379620552063,
-0.2925751209259033,
0.25163424015045166,
0.29064327478408813,
-0.333095520734787,
0.25398629903793335,
-0.13986949622631073,
-0.6013387441635132,
0.6148360967636108,
-0.23529307544231415,
0.06771034002304077,
-0.34824275970458984,
0.03346279263496399,
0.03977055847644806,
0.2608744502067566,
1.0613346099853516,
-0.4873667061328888,
0.2817244231700897,
0.2836640775203705,
-0.2989961802959442,
0.820574164390564,
0.36768677830696106,
-0.12319189310073853,
-0.42135268449783325,
0.27000242471694946,
-0.27887222170829773,
0.1668754369020462,
0.1954801231622696,
-0.07773500680923462,
-0.21646106243133545,
-0.1446639597415924,
-0.34516486525535583,
-0.09423210471868515,
0.41852033138275146,
-0.1207851693034172,
-0.49746015667915344,
0.11953309178352356,
-0.144530788064003,
-0.015192355029284954,
-0.3786463737487793,
-0.29868441820144653,
-0.12458451092243195,
-0.32586225867271423,
0.3902309536933899,
0.3223569393157959,
-0.182169571518898,
-0.17944075167179108,
-0.6031811833381653,
-0.3392362594604492,
0.4488113820552826,
-0.3352729380130768,
-0.14634843170642853,
0.07983973622322083,
0.34392422437667847,
0.4494934678077698,
-0.10666836053133011,
-0.09208095073699951,
-0.04590757563710213,
0.5744909048080444,
-0.7069397568702698,
-0.18957340717315674
] |
6,819,596 |
Fluvoxamine maleate, a serotonergic antidepressant; a comparison with chlorimipramine.
|
Coleman B S BS, Block B A BA
|
Progress in neuro-psychopharmacology & biological psychiatry . Vol. 6, No. 4-6, 1982
|
1. Fluvoxamine is a potent serotonin re-uptake inhibitor, with little or no noradrenergic or anticholinergic activity. 2. The results of three studies using an almost identical protocol with a prospectively randomized, double-blind design comparing fluvoxamine and chlorimipramine are presented. 3. In a population of 98 subjects suffering from a variety of depressive conditions, there was a marked improvement over four weeks in both groups. dosage was maintained between 150 and 300 mg per day. 4. There were no changes of clinical importance in vital signs, hematology or biochemistry, but pulse rates increased in the chlorimipramine group. 5. There were fewer concurrent signs and symptoms in the fluvoxamine group, especially those attributable to anticholinergic activity.
|
https://pubmed.ncbi.nlm.nih.gov/6819596/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6819596
|
[
0.6709081530570984,
1.1780710220336914,
-2.1906049251556396,
-2.320425033569336,
1.193049430847168,
0.6015926599502563,
1.1809395551681519,
-1.001351237297058,
-0.047940198332071304,
0.5447441339492798,
0.11326773464679718,
1.7486051321029663,
-1.1632007360458374,
0.06270736455917358,
0.44993895292282104,
-0.2317560613155365,
-1.1931506395339966,
-0.6111616492271423,
1.4939688444137573,
-1.7165508270263672,
-0.2148451805114746,
-1.3767590522766113,
-0.5769428014755249,
-0.1602851301431656,
-0.024136267602443695,
-0.0384957529604435,
-0.4594936966896057,
1.306580662727356,
0.3908672332763672,
1.2495107650756836,
-0.609692394733429,
0.49593397974967957,
1.0060023069381714,
-1.1605714559555054,
1.2888134717941284,
-1.0264562368392944,
0.8753582835197449,
-0.09776442497968674,
-0.31009483337402344,
-0.8025034666061401,
0.1182175874710083,
0.3815948963165283,
0.11081093549728394,
0.31557852029800415,
1.1289494037628174,
0.6201630234718323,
0.19751018285751343,
0.5025333762168884,
0.9499689936637878,
0.3793647587299347,
-0.4506898522377014,
0.7941452860832214,
-1.03763747215271,
-0.7039834260940552,
1.6372963190078735,
0.2345282882452011,
-0.41795676946640015,
0.6587458848953247,
0.5247891545295715,
-0.20920734107494354,
0.3228466808795929,
-0.35270652174949646,
0.1719287782907486,
0.5170676708221436,
-1.2517727613449097,
1.3867679834365845,
0.13755673170089722,
0.019080309197306633,
0.18329410254955292,
0.375185489654541,
-0.0720493271946907,
1.1914944648742676,
-0.00023365272500086576,
-0.5423000454902649,
0.6716221570968628,
0.8272069096565247,
-0.567390501499176,
2.1548850536346436,
0.41252249479293823,
0.12935754656791687,
-1.2485631704330444,
-0.44751420617103577,
0.12132120132446289,
-0.27044928073883057,
0.39441385865211487,
0.12710653245449066,
-1.031239628791809,
-0.4175742566585541,
0.5358409285545349,
-1.0250964164733887,
0.9641987085342407,
-0.742038905620575,
-1.095291018486023,
0.3440994620323181,
-0.40669959783554077,
-0.6555917859077454,
-0.2404293417930603,
0.7734823226928711,
-0.0595146007835865,
0.5587778091430664,
-0.009897617623209953,
-0.09929996728897095,
-0.6022483110427856,
-0.3023371696472168,
-0.919649064540863,
-0.7526571750640869,
-0.5460314750671387,
-0.7455571293830872,
0.07175814360380173,
-0.18564371764659882,
-0.2927492558956146,
0.4250747561454773,
-0.3724517822265625,
0.14958985149860382,
1.354171633720398,
0.8560448884963989,
0.1812000423669815,
-0.1455986201763153,
-0.09200400114059448,
0.007270549889653921,
0.7121590375900269,
0.43646156787872314,
-0.2013392150402069,
0.03793288767337799,
-0.0223141647875309,
0.1429491490125656,
0.3558685779571533,
-0.22418925166130066,
0.14664283394813538,
-1.0485976934432983,
-0.7693243026733398,
0.7827715277671814,
-0.7952062487602234,
-0.3779512941837311,
-1.1671181917190552,
-0.3964512050151825,
0.5218282341957092,
1.2497526407241821,
0.46504268050193787,
-0.06211630254983902,
-0.520157516002655,
0.1775241494178772,
-0.30167046189308167,
0.09940510243177414,
-0.8535068035125732,
-0.33582744002342224,
0.44401484727859497,
0.30692198872566223,
0.17379704117774963,
0.05592243745923042,
0.35326457023620605,
0.6450231075286865,
0.20427510142326355,
-0.5797235369682312,
-0.17510193586349487,
0.06189151108264923,
0.9162906408309937,
0.25223615765571594,
0.15393416583538055,
0.41849207878112793,
-0.08399154245853424,
-0.13218000531196594,
0.0502217561006546,
0.3054189682006836,
-0.1910858154296875,
-0.3034874200820923,
0.45615753531455994,
-0.24750223755836487,
0.22423575818538666,
-0.35965695977211,
-0.4924249053001404,
0.14016862213611603,
0.24956022202968597,
-0.07148391008377075,
-0.038179799914360046,
0.22513967752456665,
0.4262085258960724,
0.30213043093681335,
0.39459291100502014,
-0.20552445948123932,
0.10644105821847916,
-0.012801287695765495,
-0.1056286171078682,
-0.1176697388291359,
0.07185765355825424,
-0.7277029156684875,
0.04985448718070984,
-0.6270667314529419,
-0.05815254524350166,
0.14958982169628143,
-0.32810670137405396,
-0.03276708349585533,
-0.1984255164861679,
-0.37208548188209534,
0.5147066712379456,
-0.0461311973631382,
-0.13526342809200287,
0.18078334629535675,
0.03728799894452095,
0.16715140640735626,
-0.17795990407466888,
0.4751974940299988,
0.47302162647247314,
0.2177693396806717,
-0.13720034062862396,
0.2588310241699219,
-0.20309530198574066,
0.5941471457481384,
-0.48063892126083374,
0.29071125388145447,
-0.016224095597863197,
0.05272766575217247,
0.32770687341690063,
-0.10822344571352005,
0.030293304473161697,
0.26724758744239807,
-0.21098142862319946,
-0.21578773856163025,
-0.1865357607603073,
-0.009160683490335941,
0.07735460996627808,
0.22520965337753296,
-0.2643561363220215,
-0.20109359920024872,
0.1292533129453659,
0.21941684186458588,
0.20020078122615814,
-0.057749468833208084,
0.07091977447271347,
-0.29881900548934937,
-0.29613685607910156,
0.10272911190986633,
-0.12222836911678314,
-0.0312945619225502,
0.09238235652446747,
0.16315603256225586,
-0.38978126645088196,
0.17817805707454681,
0.2536158561706543,
0.26018184423446655,
0.05431252345442772,
-0.7361698746681213,
-0.14084501564502716,
-0.4805864989757538,
0.13612230122089386,
-0.45505571365356445,
0.1305927336215973,
-0.15858900547027588,
0.10326001793146133,
-0.22165179252624512,
0.06801588088274002,
0.25624996423721313,
0.15274769067764282,
0.16017797589302063,
0.17864753305912018,
0.006665614899247885
] |
6,819,598 |
A comparison of the safety and efficacy of bupropion HCL and amitriptyline hcl in depressed outpatients.
|
Remick R A RA, Campos P E PE, Misri S S, Miles J E JE, Van Wyck Fleet J J
|
Progress in neuro-psychopharmacology & biological psychiatry . Vol. 6, No. 4-6, 1982
|
1. Thirty adult outpatients diagnosed with depressive illness were treated with either bupropion HCL or amitriptyline HCL. 2. Weekly ratings of efficacy and safety were undertaken using the Hamilton Depression, Hamilton Anxiety, Clinical Global Improvement, and Treatment Emergent Symptom Scales. Periodic physical investigations were also performed. 3. After 4 weeks of active treatment patients in both drug groups showed significant improvement on all rating scales. 4. The side effect profile of each drug was clinically different from one another with a notable absence of anticholinergic side effects characteristic of the bupropion group. 5. No significant laboratory or physical changes were found although slight changes in weight were noted with bupropion patients having a slight weight loss and amitriptyline patients a slight weight gain. There were no withdrawal effects from discontinuing either drug.
|
https://pubmed.ncbi.nlm.nih.gov/6819598/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article"
] |
6819598
|
[
-0.9756881594657898,
1.893507480621338,
-1.4536629915237427,
-1.342793583869934,
-0.3682805001735687,
0.37302592396736145,
0.5827621817588806,
-0.5259544849395752,
0.7869985103607178,
0.20231448113918304,
-0.9207665324211121,
1.7233253717422485,
0.019552795216441154,
0.0007814821437932551,
-0.3283143639564514,
0.11694516986608505,
0.2242032289505005,
0.08950310200452805,
0.28766414523124695,
-1.7586314678192139,
-0.3347432315349579,
0.2194238156080246,
-0.2582029402256012,
-0.8321946263313293,
0.5960337519645691,
-0.24244201183319092,
-0.8795409798622131,
1.676232933998108,
-0.6381415724754333,
0.8263651728630066,
-0.05218449980020523,
-0.2297324687242508,
0.922146201133728,
0.0004043114313390106,
0.5603794455528259,
-0.6413273811340332,
0.6234208941459656,
-0.25269028544425964,
-1.5892269611358643,
-0.1964951604604721,
0.4988557994365692,
0.5408582091331482,
-0.1869506984949112,
-0.18590006232261658,
0.7627986669540405,
0.7425552606582642,
-0.45334380865097046,
0.010863564908504486,
0.1898481696844101,
-0.7747341394424438,
0.05679637938737869,
1.4841474294662476,
-1.368688941001892,
-0.6126374006271362,
2.5882041454315186,
0.337767094373703,
0.6800654530525208,
1.0732903480529785,
0.30087801814079285,
-0.27304014563560486,
1.027933120727539,
-0.8274078369140625,
0.21902170777320862,
0.9709285497665405,
-0.6992896795272827,
0.42727476358413696,
0.251138299703598,
0.4500606954097748,
-1.508447527885437,
0.7815029621124268,
-0.6402195692062378,
0.05042821913957596,
0.16173745691776276,
0.5173454880714417,
1.4327030181884766,
0.8559013605117798,
0.15194834768772125,
1.7965697050094604,
-0.14480933547019958,
0.2306860089302063,
0.11742693930864334,
-0.08858142793178558,
-0.846979022026062,
0.36328938603401184,
-0.09845598042011261,
0.1948222517967224,
-0.755648136138916,
-0.6196494698524475,
0.03180793672800064,
-0.9517078399658203,
-0.1692200005054474,
-0.43994924426078796,
-1.4054949283599854,
1.0488560199737549,
-1.0613330602645874,
0.3990340530872345,
-0.36030852794647217,
-0.1580137014389038,
-0.42141634225845337,
-0.5076475143432617,
-0.10351065546274185,
-0.4823864996433258,
0.16692447662353516,
-0.8375566601753235,
-0.8929125070571899,
-0.34588271379470825,
-0.2654710114002228,
-0.868553102016449,
-1.0245802402496338,
-1.2730798721313477,
0.3660934865474701,
-0.6280867457389832,
0.2054106891155243,
-0.9285351634025574,
0.5834547281265259,
0.8945474624633789,
0.3681967854499817,
0.39639177918434143,
-0.09866637736558914,
0.4505862593650818,
0.5979783535003662,
1.1635096073150635,
-0.194822296500206,
1.0458027124404907,
-0.27890297770500183,
0.1649380326271057,
0.6264267563819885,
0.7637320756912231,
-0.036283910274505615,
-0.664382815361023,
-0.9753879904747009,
0.2682240903377533,
-0.5172598958015442,
-0.7144235968589783,
-0.9455224275588989,
-0.46818265318870544,
-0.015408634208142757,
1.738415241241455,
0.04165743291378021,
-0.34571173787117004,
0.5515871047973633,
0.8210267424583435,
-0.4948694407939911,
0.30512699484825134,
-1.694227695465088,
-0.26962897181510925,
-0.19753704965114594,
0.14520540833473206,
-0.3217467665672302,
-0.6421647667884827,
0.12572212517261505,
0.8394773602485657,
0.6509289741516113,
-0.07375211268663406,
0.019015124067664146,
0.15707674622535706,
0.48375457525253296,
0.11566092818975449,
-0.18682214617729187,
-0.29083091020584106,
-0.34425094723701477,
-0.3900284469127655,
-0.08521997183561325,
0.14748820662498474,
-0.04849454015493393,
-0.3940875828266144,
-0.0705522894859314,
-0.467317134141922,
0.6694028973579407,
-0.3695254623889923,
-0.9878878593444824,
0.17861835658550262,
0.7079917788505554,
0.10461364686489105,
-0.7415379285812378,
0.6460458040237427,
0.5331762433052063,
0.15781773626804352,
0.9075774550437927,
-0.7528321743011475,
-0.40819209814071655,
-0.14548978209495544,
0.6137232184410095,
0.008791898377239704,
-0.4145716726779938,
-0.01890830136835575,
-0.19077827036380768,
-0.47499772906303406,
0.2986358106136322,
0.12192357331514359,
-0.07655427604913712,
0.1429993063211441,
-0.26745909452438354,
-0.4080561697483063,
0.6493515968322754,
-0.2398371547460556,
-0.5132962465286255,
-0.428002268075943,
0.4133927822113037,
-0.09629207849502563,
-0.4259701669216156,
0.6992290019989014,
-0.01984778419137001,
0.20055057108402252,
-0.1980905532836914,
-0.10642087459564209,
-0.8214067220687866,
0.7654123902320862,
-0.19201374053955078,
1.0305671691894531,
0.43093687295913696,
-0.04390040412545204,
0.34229856729507446,
0.20791424810886383,
0.8162094354629517,
0.42468273639678955,
0.3390893042087555,
-0.22973790764808655,
0.47931426763534546,
-0.3515298664569855,
0.08818786591291428,
-0.014702564105391502,
0.13631218671798706,
0.11883629113435745,
-0.6012595891952515,
0.009913451038300991,
0.03587322682142258,
0.46673861145973206,
0.14341387152671814,
0.22326959669589996,
-0.3682771325111389,
0.15865345299243927,
0.019754750654101372,
-0.004913178738206625,
0.09044681489467621,
-0.12177092581987381,
-0.27402612566947937,
0.3144925534725189,
-0.3598667085170746,
0.5481677651405334,
-0.08388194441795349,
-0.6661285758018494,
-0.11259953677654266,
-0.6773325204849243,
0.3906252086162567,
-0.3174194395542145,
0.03696953132748604,
0.0005245742504484951,
0.23985682427883148,
0.5388309955596924,
-0.04543975368142128,
0.2497648447751999,
0.02482520416378975,
0.1660023033618927,
0.7837336659431458,
-0.04359157383441925
] |
6,819,749 |
beta-Carotene in the treatment of erythropoietic protoporphyria. A short review.
|
Krook G G, Haeger-Aronsen B B
|
Acta dermato-venereologica. Supplementum . Vol. 100, 1982
|
A review of published trials with beta-carotene and/or canthaxanthin treatment of erythropoietic protoporphyria is presented. Increased tolerance to sunlight is reported in about 85% of the cases in uncontrolled studies. In the only controlled trial on record no difference was found between beta-carotene and placebo. Correlations between the results of carotenoid treatment and phototests have been reported in some studies, but denied in others. During treatment the protoporphyrin levels in erythrocytes were significantly increased in one study, but decreased or unaffected in others. A possible mechanism of photoprotection by beta-carotene is briefly presented. To date no serious side effects or hypervitaminosis-A induced by beta-carotene have been reported.
|
https://pubmed.ncbi.nlm.nih.gov/6819749/
|
[
"Clinical Trial",
"Journal Article"
] |
6819749
|
[
-0.02033710852265358,
0.6691397428512573,
-2.4184603691101074,
-2.29471492767334,
0.26318931579589844,
0.5794933438301086,
0.2510484457015991,
0.5015195608139038,
-3.217306613922119,
1.265635371208191,
0.4832823872566223,
0.9987550377845764,
-0.39013221859931946,
0.2960965931415558,
-0.14711998403072357,
-0.10056623816490173,
0.25530996918678284,
-0.42915910482406616,
1.4262967109680176,
-3.2835142612457275,
0.8524356484413147,
-0.7002801895141602,
-0.22581705451011658,
-0.31846460700035095,
-0.5811782479286194,
-0.850688099861145,
-0.8054240942001343,
0.8245887756347656,
-0.6410096883773804,
1.8637181520462036,
-0.5871267318725586,
0.6105748414993286,
0.9565634727478027,
0.40930354595184326,
-0.17477795481681824,
-0.025333955883979797,
1.1951041221618652,
-0.2722488343715668,
-1.0576280355453491,
0.6638759970664978,
0.8478543758392334,
0.5273018479347229,
-0.18761691451072693,
-0.02175510860979557,
1.7502567768096924,
0.32969793677330017,
0.269797682762146,
-0.2290576696395874,
-0.8301976919174194,
-0.7380268573760986,
-1.309467077255249,
0.3326314389705658,
-0.8175293207168579,
-0.1891828179359436,
1.6358250379562378,
0.456388384103775,
0.3754328787326813,
1.0866543054580688,
1.399596095085144,
-0.670359194278717,
1.544571042060852,
-0.015450667589902878,
0.2651905119419098,
0.22899523377418518,
-0.3176831305027008,
0.10790253430604935,
0.3855699598789215,
-1.0082066059112549,
-1.8615021705627441,
0.8322983980178833,
0.12845765054225922,
0.5051111578941345,
0.2293282449245453,
-0.11215014010667801,
0.6467902064323425,
-0.24382279813289642,
-0.5485448837280273,
-0.6229584217071533,
0.8411098718643188,
0.035673078149557114,
0.45723336935043335,
-0.4015842080116272,
-0.28517255187034607,
0.2621895670890808,
-0.7159578204154968,
-0.009586211293935776,
-0.47486475110054016,
-0.7223920822143555,
1.4853413105010986,
-0.7571355104446411,
-0.006724284961819649,
-0.7578336596488953,
-0.973167359828949,
0.20580808818340302,
0.7791182398796082,
0.47607672214508057,
-0.43254223465919495,
-0.28781041502952576,
-0.2851344048976898,
-0.6009944081306458,
0.41763415932655334,
0.4436012804508209,
-0.22985830903053284,
-0.24668431282043457,
-0.30885064601898193,
-0.3393946588039398,
0.3784078061580658,
-0.1987057328224182,
-0.20726878941059113,
-0.5120068192481995,
-0.1884116232395172,
-0.09345920383930206,
-1.1547340154647827,
-0.05321274697780609,
0.939877986907959,
0.7988042235374451,
0.3753706216812134,
-0.5053391456604004,
-0.3459508717060089,
0.23040905594825745,
-0.35722339153289795,
0.5891115665435791,
-0.10581622272729874,
0.6435648202896118,
-0.8203017711639404,
0.5747844576835632,
0.2349490523338318,
-0.08671336621046066,
-0.5274509787559509,
-0.4520806670188904,
-0.3583378791809082,
1.0718919038772583,
0.6554490923881531,
-0.709934651851654,
-0.8846094012260437,
0.16717025637626648,
0.461171418428421,
1.5571244955062866,
0.6844371557235718,
-0.42782703042030334,
-0.30203336477279663,
0.04859660565853119,
-0.18363715708255768,
0.4137369394302368,
-1.214341640472412,
0.14298321306705475,
-0.14692889153957367,
0.08990316838026047,
-0.6424323916435242,
0.11680800467729568,
-0.08768333494663239,
0.39428892731666565,
1.0734754800796509,
-0.5489506125450134,
-0.18761318922042847,
0.04234101623296738,
-0.006911684758961201,
-0.36778178811073303,
0.1813047081232071,
-0.2776191830635071,
-0.020015880465507507,
-0.038568004965782166,
-0.09771201759576797,
0.6344841122627258,
0.3645384609699249,
0.1362377107143402,
0.25528785586357117,
0.08298368006944656,
0.2099693864583969,
0.18445557355880737,
-0.7697504758834839,
0.12595881521701813,
0.4123113453388214,
-0.09622360020875931,
-0.7694944143295288,
-0.10197487473487854,
0.28839734196662903,
-0.12932968139648438,
1.0264302492141724,
-0.7099743485450745,
-0.40483415126800537,
0.5099238157272339,
0.14779874682426453,
-0.35385772585868835,
0.24939295649528503,
-0.14693541824817657,
-0.5706915855407715,
0.24802662432193756,
0.9560890197753906,
-0.15747706592082977,
-0.19385863840579987,
0.5829483866691589,
-0.2602578401565552,
-0.2638436555862427,
0.6312724351882935,
-0.0630025789141655,
-0.023896558210253716,
-0.1684330403804779,
0.3053708076477051,
0.053042151033878326,
0.17005887627601624,
0.07563044875860214,
-0.18232691287994385,
0.017419202253222466,
-0.6105546951293945,
0.04709157347679138,
0.11090511828660965,
0.061868585646152496,
-0.1059645265340805,
0.6203542947769165,
0.054611898958683014,
-0.1497243046760559,
-0.22917748987674713,
0.16178590059280396,
0.35570821166038513,
0.22001715004444122,
0.030974268913269043,
0.605864405632019,
-0.5046414136886597,
0.2725852131843567,
-0.4202977120876312,
-0.006066145375370979,
0.14565935730934143,
-0.36748188734054565,
-0.1732383370399475,
-0.12052460014820099,
0.06276089698076248,
0.21637558937072754,
0.008140349760651588,
-0.24682903289794922,
0.09049031883478165,
-0.02970709092915058,
-0.19209828972816467,
-0.06612605601549149,
-0.4559701979160309,
-0.3943844735622406,
0.6013237833976746,
0.10510168224573135,
-0.11848283559083939,
-0.10556330531835556,
0.1417970210313797,
-0.6428860425949097,
-0.08474487066268921,
-0.2305854856967926,
-0.025614097714424133,
-0.029639767482876778,
-0.02327527292072773,
0.034869611263275146,
0.1560361385345459,
-0.5927547216415405,
-0.03873153775930405,
0.05132342129945755,
-0.14993417263031006,
0.3065013289451599,
0.044185571372509,
-0.3070661425590515
] |
6,819,891 |
Effect of total parenteral nutrition on survival in advanced colon cancer.
|
Nixon D W DW, Lawson D H DH, Kutner M H MH, Moffitt S D SD, Ansley J J, Heymsfield S B SB, Lynn M J MJ, Wesley M M, Yancey R R, Rudman D D
|
Cancer detection and prevention . Vol. 4, No. 1-4, 1981
|
To determine if total parenteral nutrition (TPN) with constant infusion of hypertonic glucose and amino acids by central vein (35 kcal/kg/day) would influence survival in advanced colorectal carcinoma, 50 patients were randomized to receive either chemotherapy alone or the same drugs plus TPN for 14 days before treatment and a variable period thereafter. Overall median survival was significantly decreased in the TPN patients (79 vs 305 days, P = 0.03). Survival was significantly decreased in the TPN patients who had lost the least percentage of premorbid weight (0-6%) (66 vs 398 days, P = 0.02), and in all TPN males (61 vs 209 days, P = 0.03), when compared to similar controls. TPN did not increase survival in any patient subcategory. Catheter-related and metabolic complications were uncommon. We conclude that TPN as used in this study did not prolong median survival in the group as a whole, and may have shortened survival in males and in patients with little or no prior weight loss.
|
https://pubmed.ncbi.nlm.nih.gov/6819891/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6819891
|
[
-0.24080026149749756,
1.498117446899414,
-1.1556779146194458,
-2.4239790439605713,
1.0174908638000488,
0.36357858777046204,
0.45790889859199524,
-1.0331121683120728,
-0.3451424539089203,
-0.8786506652832031,
-1.2833888530731201,
1.4498543739318848,
0.14935393631458282,
-0.34325969219207764,
-0.5394147038459778,
0.07474065572023392,
-0.5807657241821289,
-0.8403603434562683,
-0.49787744879722595,
-2.043116807937622,
0.38848650455474854,
0.11722956597805023,
-0.7050504684448242,
0.892127275466919,
-0.8319748640060425,
-0.12707410752773285,
-0.7884684205055237,
0.8249610662460327,
-0.44904065132141113,
0.7888917326927185,
0.22178877890110016,
0.0858413577079773,
0.6160268783569336,
-0.8540502190589905,
0.6979820728302002,
0.797126829624176,
1.3265959024429321,
0.09662629663944244,
-0.15209275484085083,
0.15612980723381042,
1.1504653692245483,
0.3402199149131775,
-0.047543492168188095,
-0.8496590256690979,
0.9525517225265503,
0.3801146149635315,
0.5780773758888245,
-0.0765395238995552,
0.6081136465072632,
-0.10022630542516708,
-0.7818460464477539,
0.9254523515701294,
-1.7695035934448242,
-0.4116665720939636,
1.025152325630188,
0.3478814363479614,
-0.051015689969062805,
0.721061110496521,
0.037599388509988785,
-0.4560224711894989,
0.3071253001689911,
-0.06863371282815933,
0.08008911460638046,
-0.34526050090789795,
-0.566264271736145,
-0.5800259709358215,
0.057675253599882126,
-0.021187391132116318,
-0.6675229072570801,
1.0159555673599243,
-0.7691477537155151,
0.32359614968299866,
0.36330267786979675,
-0.12609076499938965,
0.6892606019973755,
0.7211164832115173,
-0.22151337563991547,
1.6027551889419556,
0.36666351556777954,
0.5689330697059631,
-0.6388441324234009,
-0.30706191062927246,
-0.6953095197677612,
0.48109591007232666,
0.4951270520687103,
0.3440115451812744,
-0.9141170978546143,
-0.21435898542404175,
0.9920344352722168,
-1.2266514301300049,
0.49747079610824585,
-0.4897311329841614,
-0.7945902347564697,
0.3052859902381897,
-0.19474908709526062,
0.16517587006092072,
0.22237935662269592,
0.25209280848503113,
-0.18840540945529938,
-0.35742276906967163,
-0.049546774476766586,
-0.06651126593351364,
-0.21765360236167908,
0.45287466049194336,
-0.08240678906440735,
-0.45403945446014404,
-0.448475182056427,
-0.5310906767845154,
-0.5025856494903564,
-0.12373922765254974,
0.15231764316558838,
-0.6400305032730103,
0.31100013852119446,
-1.216144323348999,
0.20124736428260803,
0.6711134910583496,
0.11615853756666183,
-0.8313184976577759,
0.13358283042907715,
-0.5068458914756775,
-0.529894232749939,
0.2626189887523651,
-0.20827710628509521,
1.123814582824707,
0.03703700751066208,
0.08565974980592728,
-0.06394105404615402,
0.868768572807312,
0.1690741628408432,
-0.28454506397247314,
0.23932626843452454,
0.5991937518119812,
0.199341282248497,
-0.587881326675415,
-0.8026537895202637,
-0.3558428883552551,
-0.09920965880155563,
0.760064959526062,
0.14008864760398865,
-0.6393128037452698,
0.4559909701347351,
0.2690648138523102,
-0.6061792969703674,
0.34698915481567383,
-0.8679413795471191,
0.07776079326868057,
-0.2680729031562805,
0.01804625801742077,
-0.22016939520835876,
0.14307701587677002,
-0.18435899913311005,
0.34307074546813965,
0.49304282665252686,
-0.4057263433933258,
-0.5062963962554932,
0.18133920431137085,
-0.0886547788977623,
-0.015135225839912891,
-0.970384955406189,
0.06064225360751152,
0.39195311069488525,
-0.2980678379535675,
-0.1958671510219574,
-0.948747992515564,
0.12622801959514618,
0.06028220057487488,
-0.1666916310787201,
0.3609241247177124,
-0.2524610161781311,
-0.34571516513824463,
-0.39575713872909546,
-0.265357106924057,
0.4517447352409363,
0.3876035511493683,
-0.4157264530658722,
-0.41334837675094604,
0.9075822234153748,
0.1219426691532135,
0.49904748797416687,
0.11604931950569153,
0.38491180539131165,
-0.2351074516773224,
0.15843555331230164,
-0.0484798289835453,
0.18514703214168549,
0.029491327702999115,
-0.1283636838197708,
-0.39148133993148804,
0.5733202695846558,
-0.03396159037947655,
0.12234792858362198,
0.08167856186628342,
0.1420794278383255,
0.23925292491912842,
0.3468368649482727,
-0.08687786012887955,
-0.24583014845848083,
-0.14643046259880066,
0.4806117117404938,
0.13974076509475708,
-0.361244797706604,
0.11887351423501968,
-0.15054714679718018,
0.29145193099975586,
-0.5656087398529053,
-0.5646725296974182,
-0.3602941036224365,
0.4558347463607788,
-0.6414266228675842,
0.46373772621154785,
0.30113568902015686,
-0.020722074434161186,
-0.012650929391384125,
-0.17238767445087433,
-0.0010494620073586702,
0.0198969766497612,
0.33431223034858704,
0.08659198135137558,
-0.36906763911247253,
0.04409656673669815,
0.0997246727347374,
-0.05076891928911209,
0.028658922761678696,
-0.20898893475532532,
-0.06791339814662933,
-0.1708052009344101,
-0.14243455231189728,
0.2681429088115692,
0.15206214785575867,
-0.16430224478244781,
-0.1153433620929718,
-0.07539588958024979,
0.0806613489985466,
-0.14599889516830444,
0.059937842190265656,
-0.09619788080453873,
-0.0849314033985138,
-0.21316224336624146,
0.013941304758191109,
0.4172625243663788,
0.3595086336135864,
-0.6020801067352295,
-0.0037750783376395702,
-0.19731742143630981,
0.2151120901107788,
0.18681427836418152,
0.13126526772975922,
-0.1708604395389557,
-0.06770847737789154,
0.19956132769584656,
-0.10270809382200241,
-0.06466356664896011,
-0.02336529642343521,
0.4022296965122223,
0.3176935613155365,
-0.17771674692630768
] |
6,819,898 |
Effect of metoclopramide and lisuride on hypophyseal and gonadal function in men.
|
Gräf K J KJ, Schmidt-Gollwitzer M M, Horowski R R, Dorow R R
|
Clinical endocrinology . Vol. 17, No. 3, 1982 Sep
|
The effects of chronic treatment over 7 weeks with metoclopramide and lisuride alone as well as the combination of both drugs were studied on basal and TRH/LHRH stimulated serum PRL, testosterone, LH, FSH, GH, and TSH concentrations. The study was conducted under double-blind placebo-controlled conditions and included twenty-four healthy male volunteers. In addition, repeated seminal fluid analyses were performed before, during and after treatment. While the known PRL-stimulatory effect of metoclopramide and the PRL-lowering effect of lisuride could be confirmed, we were unable to demonstrate any substance-related effects on the other hypophyseal or gonadal hormones. In contrast to previously published data no adverse effects of metoclopramide on sperm analysis could be demonstrated.
|
https://pubmed.ncbi.nlm.nih.gov/6819898/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6819898
|
[
-0.6951227784156799,
0.8170934319496155,
-1.3663357496261597,
-1.799697995185852,
0.23135390877723694,
0.30890798568725586,
0.8572430610656738,
0.48051273822784424,
-1.560376763343811,
0.6963815689086914,
0.05826287716627121,
1.4180645942687988,
0.1485247164964676,
0.8266294002532959,
0.5503116846084595,
0.6328385472297668,
-0.6175044178962708,
0.3933035135269165,
0.6739485859870911,
-1.6486775875091553,
1.129595398902893,
-0.2960686683654785,
-0.12849915027618408,
-0.8123045563697815,
1.9489389657974243,
-1.524140477180481,
-0.5024502873420715,
0.36755433678627014,
-0.4320579469203949,
0.5143413543701172,
0.3986375331878662,
0.40216222405433655,
0.7814051508903503,
-0.21134096384048462,
0.7311726808547974,
-0.43174228072166443,
0.8775810599327087,
0.4902406334877014,
0.15439555048942566,
-0.14664581418037415,
-0.03595825657248497,
-0.27540266513824463,
0.8744753003120422,
-0.30642569065093994,
1.6701003313064575,
0.4860822856426239,
0.10576336830854416,
0.03498468175530434,
0.4139738380908966,
-0.3371933698654175,
-0.47497498989105225,
0.7699149250984192,
-0.6526833176612854,
-0.19418556988239288,
0.9939166307449341,
0.4545257091522217,
0.8779402375221252,
-0.039340630173683167,
1.292018175125122,
-1.3453288078308105,
1.3706574440002441,
0.5239115357398987,
-0.2831074297428131,
1.4040764570236206,
-0.17971979081630707,
0.5070976614952087,
0.05275827646255493,
-0.36596959829330444,
-1.3173896074295044,
1.1939719915390015,
-0.25424784421920776,
-0.2483639270067215,
1.0656757354736328,
-0.6821541786193848,
0.9099825024604797,
0.3308737576007843,
-0.077057383954525,
0.7463720440864563,
0.6841840147972107,
-0.28997012972831726,
0.4639384150505066,
-0.3984878361225128,
0.36108022928237915,
-0.40670499205589294,
0.2902176082134247,
-0.4695102870464325,
-0.06032299995422363,
-1.1884617805480957,
0.20278532803058624,
-0.4918956756591797,
-0.15892161428928375,
-0.485227108001709,
-0.9958359003067017,
0.6434912085533142,
0.3041246831417084,
0.5656785368919373,
-0.37005943059921265,
0.3270729184150696,
-0.3162856996059418,
-0.011099090799689293,
-0.15799613296985626,
-0.48361048102378845,
0.3136715292930603,
0.11854193359613419,
-0.8706122040748596,
-0.2156526744365692,
-0.45763111114501953,
-0.44899529218673706,
-1.3473323583602905,
0.012214112095534801,
0.39406296610832214,
-0.9977809190750122,
-0.13234595954418182,
-0.07076077163219452,
0.5019610524177551,
0.7564502954483032,
-0.11415772140026093,
-0.24327059090137482,
-0.15630412101745605,
-0.11637625098228455,
0.0328962616622448,
1.1846572160720825,
0.1782863885164261,
1.1147034168243408,
-0.7262773513793945,
0.38617029786109924,
-0.06664810329675674,
-0.025834932923316956,
-0.2699882984161377,
0.30798566341400146,
-0.8936779499053955,
0.31148266792297363,
-0.042500223964452744,
-0.8318798542022705,
-1.0542482137680054,
-0.26690730452537537,
0.5179582834243774,
0.8146435618400574,
0.35144826769828796,
-0.933765172958374,
-1.3819032907485962,
-0.027035098522901535,
0.34365299344062805,
0.3993576765060425,
-1.4053950309753418,
0.08105167001485825,
0.4736315906047821,
0.1673816293478012,
0.006676740478724241,
0.08617168664932251,
0.51888507604599,
0.43486717343330383,
1.0434160232543945,
-0.5729186534881592,
-0.3700047433376312,
-0.3652784526348114,
-0.05448075383901596,
0.02419748716056347,
0.14692948758602142,
-0.5662055015563965,
-0.1529192477464676,
-0.7892578840255737,
-0.4725828468799591,
-0.2039850950241089,
0.11123739182949066,
0.3223017752170563,
0.20121411979198456,
0.2265504151582718,
0.2452622354030609,
-0.25766047835350037,
-0.643858015537262,
-0.5826459527015686,
-0.08117422461509705,
0.028754161670804024,
0.20255175232887268,
0.6061162948608398,
0.055237747728824615,
-0.07685352116823196,
0.2713364362716675,
0.35093849897384644,
-0.3613751232624054,
-0.10163121670484543,
-0.015339446254074574,
-0.13414700329303741,
0.14860132336616516,
-0.6896204352378845,
-0.185960590839386,
0.19159971177577972,
-0.09908773005008698,
-0.4688361883163452,
0.25900891423225403,
0.30753058195114136,
-0.22298084199428558,
-0.2538158595561981,
0.5362889170646667,
-0.04514583572745323,
0.10764060914516449,
-0.6057373285293579,
-0.06542260944843292,
-0.017388546839356422,
-0.05940286070108414,
0.9909454584121704,
0.0962572768330574,
0.2628365755081177,
-0.4133058190345764,
0.020971277728676796,
-0.42998194694519043,
0.46320778131484985,
-0.5160689353942871,
0.09111612290143967,
-0.05158919468522072,
-0.08737537264823914,
-0.2547317445278168,
0.41245537996292114,
0.3524191379547119,
0.0044609480537474155,
-0.35155004262924194,
-0.09686051309108734,
-0.1908019781112671,
0.3496963679790497,
0.027994664385914803,
-0.19869156181812286,
-0.2599097192287445,
-0.47471413016319275,
-0.08173415809869766,
0.09571827948093414,
0.2644941806793213,
-0.09986276179552078,
0.06664413958787918,
0.1588224172592163,
-0.1669521927833557,
0.11764553934335709,
-0.32287514209747314,
-0.3389834463596344,
-0.1493777334690094,
0.2404206544160843,
-0.1820385903120041,
0.1371971219778061,
-0.14429014921188354,
-0.2583354413509369,
0.020361369475722313,
-0.8127814531326294,
-0.6344113945960999,
-0.4341856837272644,
0.18812942504882812,
-0.32786956429481506,
-0.29314205050468445,
0.44810596108436584,
0.11249221861362457,
0.12941047549247742,
0.13862110674381256,
-0.25073909759521484,
-0.10832654684782028,
0.3761344850063324,
-0.1913990080356598,
-0.09682390838861465
] |
6,819,904 |
Effects of oral and intravenous TRH and metoclopramide on PRL and TSH secretion in women.
|
Kauppila A A, Ylikorkala O O
|
Clinical endocrinology . Vol. 17, No. 6, 1982 Dec
|
Pituitary secretion of PRL and TSH is under the control of inhibitory dopaminergic and stimulatory TRH-mediated mechanisms. To evaluate the relationships between these regulatory systems, ten healthy women were treated with oral TRH (20 mg twice daily), a dopamine blocking drug, metoclopramide (MC) (10 mg t.d.s.) or placebo for 1 week (from 8th to 14th cycle day). Serum concentrations of PRL, TSH, T3 and T4 were determined before, at the end, and 3 days after the treatments. In addition, PRL and TSH responses to i.v. TRH (200 micrograms) or MC (10 mg) were studied at the end of the oral treatments. Oral TRH treatment was accompanied by increases in basal T3 and T4 concentrations, no change in PRL, and a decrease in TSH 3 days after the end of treatment. Oral TRH did not modify the PRL response to i.v. MC while it eliminated the TSH response to i.v. MC, possibly because of elevated concentrations of thyroid hormones. Oral MC treatment raised the concentrations of PRL, T3 and T4, and also potentiated the PRL response to i.v. TRH, whereas the TSH response remained unaltered. These results demonstrate that dopaminergic and TRH-mediated mechanisms are related in the control of PRL and TSH secretions, perhaps directly or through thyroid hormones.
|
https://pubmed.ncbi.nlm.nih.gov/6819904/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6819904
|
[
0.22015824913978577,
1.2863593101501465,
-1.0340721607208252,
-1.226860523223877,
0.8323229551315308,
0.13860563933849335,
0.7851991653442383,
0.44270429015159607,
-1.132476568222046,
0.038617316633462906,
-0.2868245542049408,
0.5401558876037598,
0.1442348062992096,
-0.19096598029136658,
-0.15234731137752533,
-0.17126703262329102,
-0.42061129212379456,
0.8027971982955933,
0.9846407175064087,
-1.2355903387069702,
0.3392566442489624,
-0.3350583612918854,
0.08887118101119995,
-0.9143477082252502,
0.7980817556381226,
-0.19396016001701355,
-1.0832804441452026,
1.2516437768936157,
0.3297167718410492,
0.6272492408752441,
0.340170681476593,
0.5041359066963196,
1.133797526359558,
-0.4180828928947449,
0.16816475987434387,
-0.5533936619758606,
3.0697402954101562,
0.0699189305305481,
-0.5770792961120605,
-0.6118810772895813,
0.36867380142211914,
-0.7429032921791077,
0.4252302348613739,
-0.5702229738235474,
0.7438809275627136,
0.8708685040473938,
1.0507078170776367,
0.3983307480812073,
0.9749146699905396,
-0.34211158752441406,
-0.4346418082714081,
0.402931272983551,
-0.3612232208251953,
0.14898264408111572,
1.315754771232605,
1.2292065620422363,
0.2305881530046463,
-0.17294707894325256,
0.9396827220916748,
-0.995554506778717,
0.5207525491714478,
0.8784270286560059,
-0.31508705019950867,
0.4603302776813507,
-0.5079582333564758,
0.9330655336380005,
0.4536975026130676,
0.9356738924980164,
-0.8614754676818848,
0.7846278548240662,
0.6615716814994812,
0.29026514291763306,
0.6256176829338074,
-0.5769008994102478,
0.6795580387115479,
0.1351340413093567,
0.1356925666332245,
0.47118350863456726,
0.7345941662788391,
0.03318177908658981,
-0.3138817846775055,
0.14374864101409912,
0.07663901150226593,
-0.701436460018158,
0.24863070249557495,
-0.7740312814712524,
-0.39852842688560486,
-0.8490636944770813,
0.4040585458278656,
-0.5455905199050903,
0.25152069330215454,
-0.2796809673309326,
-1.1927894353866577,
0.7716483473777771,
-0.5068009495735168,
0.2211213856935501,
0.16993215680122375,
1.4137734174728394,
0.04712587594985962,
0.23358577489852905,
0.22550004720687866,
-0.3840916156768799,
0.5773907899856567,
-0.01920267567038536,
-0.8850834369659424,
0.00028549047419801354,
-0.75704026222229,
-0.5305550694465637,
-0.7387723922729492,
-0.7750242948532104,
-0.3528199791908264,
-0.7010325789451599,
0.10303600877523422,
-0.14266663789749146,
0.5099201798439026,
0.7717612385749817,
-0.6131446361541748,
0.32783564925193787,
0.043312329798936844,
0.20646512508392334,
0.44622308015823364,
0.12194614857435226,
0.26614248752593994,
-0.04147792607545853,
-0.5390799641609192,
0.3146585524082184,
-0.5360211730003357,
-0.30837735533714294,
0.12092947214841843,
0.4453049898147583,
-0.35099858045578003,
-0.08957783132791519,
-0.09091716259717941,
-0.10470101237297058,
-0.22180107235908508,
-0.7245398163795471,
0.4044768512248993,
0.944176197052002,
0.38499224185943604,
-0.7020971179008484,
-0.6576326489448547,
0.16952891647815704,
0.5683310627937317,
0.14283929765224457,
-0.9108942747116089,
0.05266586318612099,
0.25607365369796753,
0.35269680619239807,
-0.3284915089607239,
0.6024953126907349,
0.5920622944831848,
0.07175913453102112,
0.25401321053504944,
-0.372761607170105,
0.22423261404037476,
-0.25642549991607666,
-0.43651801347732544,
-0.0930366963148117,
-0.2756538689136505,
-0.5273194909095764,
0.08745139092206955,
-0.26307713985443115,
-0.39455828070640564,
-0.5070359110832214,
-0.14605316519737244,
0.2668374478816986,
-0.2210911363363266,
0.32478195428848267,
-0.09776626527309418,
0.007284867577254772,
-0.650220513343811,
0.12589633464813232,
-0.1546539068222046,
0.3719066381454468,
-0.2412039190530777,
0.6367871165275574,
0.28522399067878723,
0.19724807143211365,
-0.14623819291591644,
0.1408788561820984,
0.017829162999987602,
-0.05594028905034065,
-0.08389849960803986,
0.011549325659871101,
-0.04351067915558815,
-0.8298265933990479,
-0.5762619376182556,
-0.07812414318323135,
-0.032504551112651825,
-0.07483071833848953,
0.43137308955192566,
0.17177742719650269,
-0.4895315170288086,
-0.2525790333747864,
0.19721685349941254,
-0.08565542846918106,
0.27122318744659424,
0.09797875583171844,
0.18493013083934784,
-0.17673876881599426,
0.16623187065124512,
0.7604039907455444,
0.35704705119132996,
0.6671043038368225,
-0.5045602321624756,
-0.1207897737622261,
0.46997323632240295,
0.07690033316612244,
-0.21100524067878723,
0.011451294645667076,
-0.5595307946205139,
0.20175990462303162,
-0.3569827675819397,
0.3287203907966614,
-0.0663093850016594,
-0.011645933613181114,
-0.06394760310649872,
0.007878925651311874,
-0.1445593237876892,
0.10273541510105133,
0.11265473812818527,
-0.10124935954809189,
-0.1377738118171692,
-0.42637452483177185,
0.2649298906326294,
-0.42683252692222595,
0.4102930426597595,
0.04956092685461044,
-0.07285155355930328,
0.6350801587104797,
-0.4248577356338501,
0.48928552865982056,
0.22672685980796814,
-0.4890614449977875,
0.35106146335601807,
0.039411045610904694,
-0.44288739562034607,
0.044704217463731766,
0.05066853389143944,
-0.3596189618110657,
0.4218594431877136,
-0.39470475912094116,
-0.2921546697616577,
-0.4429650604724884,
0.38807249069213867,
-0.44271594285964966,
-0.021250493824481964,
0.5977829098701477,
-0.0031183490063995123,
-0.19614242017269135,
-0.08658584207296371,
0.08337554335594177,
0.13189658522605896,
0.5243123173713684,
-0.14831547439098358,
-0.08534274995326996
] |
6,819,969 |
Cyclosporin A for immunosuppression: observations in rat heart, pancreas, and islet allograft models and in human renal and pancreas transplantation.
|
Rynasiewicz J J JJ, Sutherland D E DE, Ferguson R M RM, Squifflet J P JP, Morrow C E CE, Goetz F C FC, Najarian J S JS
|
Diabetes . Vol. 31 Suppl 4, 1982 Aug
|
Cyclosporin A (CsA) is a unique immunosuppressive cyclic polypeptide that is currently being used, either alone or in combination with low-dose prednisone, to treat recipients of renal or pancreas allografts in clinical trials. CsA is very effective in preventing rejection of heart and renal allografts in rodents, but in nontoxic doses does not consistently prevent rejection of pancreas and islet allografts. Therefore, we tested low-dose CsA in various combinations with low-dose prednisone, azathioprine, or total lymphoid irradiation in rat heart, pancreas, and islet allograft models. Several combinations are synergistic and when administered continuously can indefinitely prevent rejection of heart allografts, but only delay rejection of pancreatic allografts, transplanted across a major histocompatibility barrier, CsA by itself prolonged the survival of islet allografts transplanted across a minor, but not a major, histocompatibility barrier. CsA and azathioprine had a synergistic effect in the minor histocompatibility barrier islet transplant model, but, in the nontoxic combinations tested, could not prevent rejection indefinitely. A randomized prospective trial comparing standard immunosuppressive therapy (ALG, prednisone, and azathioprine), with CsA and low-dose prednisone for clinical renal allotransplantation is ongoing at the University of Minnesota. Current actuarial 1-yr graft survival is 93% for CsA-treated patients (N = 48) and 81% for conventionally treated patients (N = 52). Patient survival is 98% for CsA and 100% for conventionally treated patients. A pilot trial of CsA in the clinical pancreas transplant program at the University of Minnesota is also underway. Since 1978, 46 pancreas transplants have been performed in 43 patients. Of 30 technically successful pancreatic allografts, 5 of 12 recipients treated with conventional immunosuppression and 6 of 18 recipients treated with CsA currently have functioning grafts and are insulin independent between 1 and 44 months after transplantation. The results of metabolic studies are similar in conventional and CsA-treated patients with functioning pancreas grafts. Since pancreas grafts may fail for reasons other than rejection, further observations are needed to ascertain the role of CsA in clinical pancreas transplantation.
|
https://pubmed.ncbi.nlm.nih.gov/6819969/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] |
6819969
|
[
0.5513283610343933,
2.2832210063934326,
-2.3523929119110107,
-2.0559005737304688,
1.0832480192184448,
0.6172803640365601,
-0.5669583082199097,
0.7060129642486572,
-1.4674569368362427,
-0.07049717754125595,
0.24883465468883514,
1.1228193044662476,
-1.2788667678833008,
-0.05850447341799736,
0.07125680148601532,
-0.03211532533168793,
-1.3007830381393433,
1.435570240020752,
1.2080061435699463,
-1.7026528120040894,
1.3965585231781006,
0.6391034722328186,
0.027551544830203056,
0.05816137045621872,
0.5111915469169617,
-0.0492047555744648,
0.008507254533469677,
1.7767937183380127,
0.0292869433760643,
0.9069241285324097,
-1.36366868019104,
-0.611731231212616,
0.907600462436676,
0.9216113686561584,
0.1726415604352951,
0.03778735548257828,
1.243727684020996,
0.5726971626281738,
-0.0914551168680191,
0.6914520263671875,
0.6620913147926331,
0.7286231517791748,
-0.41306158900260925,
-0.5102426409721375,
1.4111615419387817,
-0.8199388384819031,
1.1172218322753906,
0.9899265170097351,
0.7354243397712708,
0.7991510033607483,
-1.3376611471176147,
-0.9266136288642883,
-1.002921223640442,
0.1090644970536232,
-0.21738198399543762,
0.9514458775520325,
0.06658220291137695,
2.0624282360076904,
0.33612534403800964,
0.03371918201446533,
0.16673000156879425,
0.4230901300907135,
-1.8756000995635986,
0.4071405529975891,
-0.591788113117218,
-0.052145808935165405,
0.8609505891799927,
-0.6593140363693237,
-0.3455509841442108,
0.1367841213941574,
0.06958497315645218,
0.624392569065094,
-0.42532649636268616,
0.8288038372993469,
-0.11449279636144638,
0.27986034750938416,
-0.5831267833709717,
0.6105401515960693,
0.8993116021156311,
0.12394072860479355,
-0.6534314155578613,
0.5535253286361694,
0.07456757128238678,
0.17304010689258575,
-0.14742034673690796,
-0.20184682309627533,
-1.1579279899597168,
0.029604896903038025,
0.40354594588279724,
-1.250952959060669,
0.0002572227967903018,
-0.45355716347694397,
-1.1307121515274048,
0.2325332909822464,
0.5885054469108582,
-0.32510867714881897,
-0.6588901281356812,
0.49456676840782166,
-1.1121845245361328,
0.2583521902561188,
0.2584965229034424,
-0.9731560945510864,
-0.2875064015388489,
0.12436912208795547,
-0.6316341757774353,
-0.39738142490386963,
-0.1601736843585968,
-0.4536222517490387,
-0.6924158334732056,
-1.4543002843856812,
-0.2596201002597809,
-0.6335352063179016,
0.07792491465806961,
-0.4225495159626007,
-0.36324918270111084,
0.2291852831840515,
0.5420904755592346,
-0.6339472532272339,
-0.2138548493385315,
0.13339802622795105,
-0.46027618646621704,
0.7584542036056519,
0.4490680992603302,
0.278515487909317,
-0.5008372068405151,
0.01220010593533516,
-0.8771961331367493,
0.11552241444587708,
0.026677677407860756,
-0.30985406041145325,
-0.7378733158111572,
0.5256426334381104,
0.22582460939884186,
-0.19931593537330627,
-1.400396466255188,
-0.5829818248748779,
0.1347459852695465,
0.6606830954551697,
0.13654355704784393,
-0.1799944043159485,
0.3366984724998474,
0.03129131719470024,
-0.22974611818790436,
-0.17364390194416046,
-1.5088729858398438,
0.06065569072961807,
-0.12032317370176315,
0.6300035119056702,
-0.6684811115264893,
-0.3442004323005676,
0.15241460502147675,
1.0814746618270874,
0.4611106812953949,
0.9431972503662109,
0.3094099462032318,
0.11871808022260666,
0.47048062086105347,
-0.15804170072078705,
0.3849996328353882,
-0.4378335475921631,
-0.182991161942482,
-0.3525224030017853,
0.22792136669158936,
-0.620686411857605,
0.6877421736717224,
-0.0819750651717186,
-0.667011022567749,
-0.08886131644248962,
0.23022392392158508,
-0.0092401634901762,
-0.940095067024231,
0.28275856375694275,
0.40252676606178284,
0.1649538278579712,
-0.9105075597763062,
0.1695464551448822,
0.4178682267665863,
0.019948648288846016,
0.05202372372150421,
-0.18843217194080353,
-0.5103760361671448,
0.0609777495265007,
0.1859162151813507,
-0.4499667286872864,
0.15272080898284912,
0.2660192847251892,
0.03375200927257538,
-0.16333359479904175,
-0.3540918231010437,
0.5460928678512573,
0.28693678975105286,
0.2903673052787781,
-0.01397358626127243,
-0.06407415121793747,
0.2706628441810608,
-0.2617969810962677,
0.5833178758621216,
-0.1283375322818756,
0.3891606628894806,
-0.1525171846151352,
0.27581146359443665,
0.16464535892009735,
0.014691988937556744,
0.34709200263023376,
-0.1709776520729065,
-0.41495630145072937,
0.15524978935718536,
0.19872422516345978,
0.1454853117465973,
0.4293139576911926,
0.42215412855148315,
0.11314141005277634,
-0.15059374272823334,
-0.012842759490013123,
-0.32992878556251526,
-0.1288348138332367,
0.1095849871635437,
0.36489418148994446,
-0.761294424533844,
0.3159538805484772,
0.048115070909261703,
-0.04297632351517677,
0.2804459035396576,
0.10085216164588928,
-0.03943900018930435,
0.0025742235593497753,
0.053352948278188705,
0.139964759349823,
-0.07901152968406677,
-0.21274039149284363,
-0.21377579867839813,
-0.07882349193096161,
-0.3497776389122009,
-0.13300780951976776,
-0.3417510688304901,
0.292441725730896,
0.20027293264865875,
-0.03910700976848602,
-0.24273987114429474,
0.1392652690410614,
-0.14284469187259674,
-0.5664598345756531,
-0.4868316352367401,
-0.21453051269054413,
0.5172176361083984,
-0.3367351293563843,
0.4940487742424011,
-0.07315769791603088,
0.0973137840628624,
0.028226187452673912,
-0.23847301304340363,
-0.0814463421702385,
0.10094520449638367,
-0.05750228837132454,
0.1436316817998886,
-0.38504937291145325
] |
6,820,075 |
Hyperammonemia in neonates receiving intravenous nutrition.
|
Thomas D W DW, Sinatra F R FR, Hack S L SL, Smith T M TM, Platzker A C AC, Merritt R J RJ
|
JPEN. Journal of parenteral and enteral nutrition . Vol. 6, No. 6
|
Inadequate arginine intake has been suggested as an etiology for hyperammonemia in neonates on parenteral nutrition. We randomized 26 nonasphyxiated neonates to receive amino acid solutions containing either 3.6 or 10.4% of total nitrogen as arginine when intravenous nutrition (IVN) therapy was initiated. Neonates in both amino acid solution study groups were observed to have significantly elevated blood ammonia (BA) concentrations during IVN (p less than 0.01) as compared to pre-IVN levels. Blood ammonia concentrations tended to be higher in infants receiving the 3.6% arginine amino acid solution. Septic infants were at particular risk for hyperammonemia as compared to nonseptic patients (p less than 0.025). Other clinical parameters including birth weight, gestational age, oxygen requirements, enteral nutritional intake, congenital anomalies, and heart disease did not appear to be related to BA concentration.
|
https://pubmed.ncbi.nlm.nih.gov/6820075/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6820075
|
[
0.5239100456237793,
1.404597520828247,
-2.9131860733032227,
-3.239126682281494,
0.8050054311752319,
-0.20216704905033112,
0.6979875564575195,
-1.2000610828399658,
-1.4813270568847656,
-0.8329851627349854,
0.041991088539361954,
1.7684242725372314,
-0.4788247346878052,
0.8565035462379456,
0.15974223613739014,
-0.4456242024898529,
-1.8596473932266235,
0.374443918466568,
1.2994797229766846,
-2.2702784538269043,
0.9673347473144531,
0.06780114024877548,
-1.5443143844604492,
-0.05394260957837105,
0.07954999059438705,
0.2109314203262329,
-0.9847070574760437,
1.6283005475997925,
-0.49605461955070496,
-0.2446547895669937,
1.1684575080871582,
-0.5612368583679199,
0.32726287841796875,
-0.7578967809677124,
1.470090627670288,
0.2728525698184967,
2.0089869499206543,
0.6669250130653381,
0.5251147150993347,
-0.0012591290287673473,
1.2745550870895386,
1.9051142930984497,
0.2169887274503708,
0.5937549471855164,
0.29220807552337646,
-0.07617076486349106,
0.35149911046028137,
-0.11897856742143631,
1.408445954322815,
0.29251787066459656,
-0.8703547716140747,
0.3202228546142578,
-0.5393990278244019,
-1.3179495334625244,
2.230135440826416,
0.7186207175254822,
0.8999952077865601,
0.7678908109664917,
1.5719904899597168,
-0.6773658990859985,
0.5434654355049133,
-0.40686869621276855,
0.17817193269729614,
-0.27696436643600464,
-2.348789691925049,
-0.804054856300354,
1.6825929880142212,
0.4114241600036621,
-1.0863748788833618,
0.4955514669418335,
-0.9070836305618286,
-0.191098153591156,
-0.0029659324791282415,
-1.12091064453125,
0.8395385146141052,
1.602705955505371,
-0.11558647453784943,
0.621168315410614,
-0.06361719220876694,
0.6757428646087646,
-1.4926058053970337,
-0.5482929944992065,
0.10688331723213196,
0.19079314172267914,
0.1782006472349167,
1.3061002492904663,
-1.2205383777618408,
-0.46962419152259827,
1.0399041175842285,
-0.606956958770752,
-0.16328559815883636,
-0.8227750658988953,
-1.561651587486267,
-0.2560376524925232,
0.00993868988007307,
0.2694542407989502,
0.13757175207138062,
0.0982576236128807,
-1.5170130729675293,
-0.3111856281757355,
0.635686457157135,
0.41244131326675415,
-0.9923653602600098,
-0.46460992097854614,
0.5869154930114746,
0.2612520754337311,
0.35327857732772827,
0.03742563724517822,
-0.9862615466117859,
-0.134110227227211,
-0.6241248250007629,
0.0053927055560052395,
-0.0503208190202713,
-0.7699077725410461,
0.15651759505271912,
0.5360345244407654,
0.11602085828781128,
-0.4674249291419983,
0.38696926832199097,
-0.49449893832206726,
0.03722335025668144,
0.21654143929481506,
-0.5436311960220337,
0.5252597332000732,
-0.6035791635513306,
0.017663272097706795,
0.5248648524284363,
-0.4661247730255127,
-0.1395265907049179,
-0.5312198996543884,
-0.14380283653736115,
0.9139494895935059,
0.9474454522132874,
-0.20232848823070526,
0.3350212872028351,
-0.2204975038766861,
0.6931110620498657,
0.2799209952354431,
0.17465336620807648,
-0.7887053489685059,
-1.1319890022277832,
0.7796125411987305,
-0.7866625189781189,
0.00487264571711421,
-0.8560516834259033,
-0.21556319296360016,
-0.3175141215324402,
-0.5702765583992004,
-0.7353996634483337,
0.2266417145729065,
-0.14202401041984558,
0.6480562686920166,
0.7545154690742493,
0.36044731736183167,
-0.1759088635444641,
-0.028880899772047997,
0.41800978779792786,
0.06778672337532043,
-0.2203570455312729,
0.2433861941099167,
0.06192989647388458,
0.1999422162771225,
-0.18453560769557953,
-0.18622997403144836,
0.407661110162735,
-0.3553674519062042,
-0.2629673182964325,
0.5881258249282837,
-0.13045775890350342,
0.7673820853233337,
-0.13037069141864777,
-0.1388215273618698,
-0.38915684819221497,
0.25220444798469543,
-0.30375736951828003,
-0.4167567789554596,
0.3867413401603699,
-0.1919989138841629,
-0.11225318908691406,
0.10271044820547104,
-0.18643353879451752,
0.05675261467695236,
0.1653880625963211,
-0.7543246746063232,
-0.3369394540786743,
-0.11481723189353943,
0.11356286704540253,
-0.7808940410614014,
-0.20049221813678741,
0.06435861438512802,
-0.18611089885234833,
0.09754689782857895,
-0.6314771771430969,
-0.30479735136032104,
-0.100859135389328,
0.4002438187599182,
-0.35798168182373047,
-0.31296306848526,
0.285936564207077,
0.02084888331592083,
0.07096440345048904,
0.19021931290626526,
-0.16696006059646606,
0.1949722170829773,
-0.17234961688518524,
0.2602730691432953,
0.30842840671539307,
0.2879669666290283,
-0.46240225434303284,
0.24403712153434753,
0.0544443316757679,
0.32651063799858093,
-0.2670431435108185,
0.47269731760025024,
0.07620435953140259,
-0.14318649470806122,
-0.1569424569606781,
0.462069571018219,
-0.5027725696563721,
-0.41272127628326416,
-0.082394540309906,
0.017168529331684113,
0.15855342149734497,
-0.24794094264507294,
0.2107858657836914,
0.39093905687332153,
0.09730512648820877,
-0.13576020300388336,
0.19370774924755096,
0.24666240811347961,
-0.30452385544776917,
-0.3641718029975891,
-0.508012592792511,
0.3900163173675537,
-0.49027419090270996,
-0.38593196868896484,
-0.19309711456298828,
0.28840965032577515,
0.1493304967880249,
-0.03650474175810814,
0.006818222813308239,
-0.35981208086013794,
0.2568521499633789,
0.061082541942596436,
-0.028690796345472336,
-0.18624696135520935,
-0.2851858139038086,
-0.018882418051362038,
-0.17838482558727264,
-0.46159955859184265,
-0.1149880588054657,
0.16576994955539703,
0.1017615795135498,
0.09449298679828644,
-0.0905807763338089,
-0.2121739387512207
] |
6,820,076 |
Selenium and vitamin E sufficiency in premature infants requiring total parenteral nutrition.
|
Huston R K RK, Benda G I GI, Carlson C V CV, Shearer T R TR, Reynolds J W JW, Neerhout R C RC
|
JPEN. Journal of parenteral and enteral nutrition . Vol. 6, No. 6
|
A randomized prospective study of LBW infants was undertaken to evaluate the effect of parenteral lipid infusions upon their antioxidant systems. Ten babies received a parenteral nutrition regimen with lipid emulsion, and ten received a regimen without lipid. Although the addition of lipid emulsion to the total parenteral nutrition regimen led to a rise in vitamin E levels, the selenium levels fell in both groups. Neither group showed evidence of deficient antioxidant systems by the peroxide hemolysis test or thiobarbituric acid test. There did not seem to be any adverse effect of the lipid infusion upon the clinical course of the infants except for hyperlipidemia. There was a better weight gain in infants receiving lipid.
|
https://pubmed.ncbi.nlm.nih.gov/6820076/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6820076
|
[
-0.780129075050354,
0.7367377281188965,
-2.9861085414886475,
-3.508147716522217,
-0.007319543045014143,
-0.4922003149986267,
-0.6925151944160461,
0.19262896478176117,
-2.3101954460144043,
-0.30485987663269043,
0.7039968967437744,
1.5177688598632812,
-0.7955276370048523,
1.1996558904647827,
0.5458466410636902,
-0.9696974754333496,
-0.37523868680000305,
0.013619711622595787,
1.1145538091659546,
-2.221313238143921,
1.2964140176773071,
1.0293797254562378,
-0.7708349823951721,
-0.2607080340385437,
0.8792938590049744,
-1.8777302503585815,
-0.5443094968795776,
0.3854652941226959,
-0.005015144590288401,
0.3293435275554657,
0.7158038020133972,
-0.16835425794124603,
-0.5391779541969299,
-0.36871930956840515,
0.8607848286628723,
0.4764961004257202,
1.6921051740646362,
0.5074367523193359,
0.004667549394071102,
1.5701106786727905,
0.8189008831977844,
0.25784486532211304,
-0.29348355531692505,
0.6270638704299927,
1.045805811882019,
-0.5779305696487427,
0.008525689132511616,
-0.43587037920951843,
0.4672169089317322,
1.2993584871292114,
0.4967891573905945,
2.597869873046875,
0.300104558467865,
-1.328274130821228,
1.6794219017028809,
1.1475751399993896,
1.3569927215576172,
0.5490189790725708,
1.3658885955810547,
-0.4091680943965912,
0.04330543056130409,
-0.11783619970083237,
1.274773120880127,
0.14247716963291168,
-2.1401379108428955,
0.19997064769268036,
0.9598243832588196,
0.45702064037323,
-1.5665600299835205,
0.2303159236907959,
-0.34860384464263916,
-0.30209580063819885,
-0.11665786802768707,
-0.523224413394928,
1.1146427392959595,
-0.031454943120479584,
0.2631362974643707,
2.06119441986084,
-0.8228595852851868,
-0.5315472483634949,
-0.40111997723579407,
-0.3017856776714325,
-0.8300539255142212,
-0.02846037596464157,
0.2381226271390915,
0.6235830783843994,
-0.906344473361969,
0.25385916233062744,
-0.40643998980522156,
-1.544073224067688,
0.341391384601593,
-0.030430296435952187,
-2.3690505027770996,
-0.15652154386043549,
-0.9356415271759033,
0.8069644570350647,
-0.8816413283348083,
0.2726961672306061,
-0.49840083718299866,
0.24136470258235931,
0.49891653656959534,
0.8570772409439087,
0.30377712845802307,
0.2577536404132843,
0.18728439509868622,
-0.1166253536939621,
0.18292704224586487,
-0.5775228142738342,
-0.780838668346405,
-0.39746978878974915,
-0.6068365573883057,
-0.5924892425537109,
0.04760280251502991,
-0.9848771095275879,
0.43967437744140625,
1.093213677406311,
0.8786681294441223,
-0.7011867761611938,
0.40982159972190857,
-0.9733266830444336,
-0.399995356798172,
1.089690089225769,
0.046844616532325745,
0.6055213809013367,
-1.0850303173065186,
0.34816500544548035,
1.0973011255264282,
-0.6611522436141968,
-0.4766535758972168,
-0.3339332938194275,
-1.078554630279541,
0.6075965166091919,
1.0247912406921387,
-0.49695658683776855,
-0.8194523453712463,
-0.14065872132778168,
0.9067726731300354,
1.1835551261901855,
-0.2011873424053192,
-0.12534107267856598,
-0.6163107752799988,
0.10111013054847717,
-1.3900238275527954,
0.6518873572349548,
-0.9362820982933044,
-0.19130848348140717,
0.16491398215293884,
-0.25253522396087646,
-0.4905655086040497,
0.5435715317726135,
-0.0801602378487587,
0.6466608047485352,
0.710178792476654,
0.33815208077430725,
0.10803740471601486,
0.33216381072998047,
0.24640977382659912,
0.6073414087295532,
-0.17805036902427673,
0.2166334092617035,
0.3821936249732971,
0.10650182515382767,
-0.252595990896225,
-0.23322682082653046,
-0.05772716552019119,
0.16338306665420532,
-0.026497941464185715,
0.11851954460144043,
0.20421816408634186,
0.15039953589439392,
-0.39879557490348816,
0.2175285369157791,
-0.8370312452316284,
1.0279237031936646,
0.15335169434547424,
0.12341133505105972,
0.9596479535102844,
-0.29102712869644165,
0.39363816380500793,
-0.5848207473754883,
-0.19931074976921082,
0.21476225554943085,
0.13113336265087128,
-0.6805596351623535,
-0.19952458143234253,
-0.9018614888191223,
0.15630480647087097,
-0.5794358849525452,
0.2158111035823822,
-0.11708308011293411,
-0.1956641674041748,
-0.24566596746444702,
-0.5923829674720764,
-0.4886362850666046,
0.14356032013893127,
0.3801668882369995,
0.3998289704322815,
-0.14132390916347504,
0.540338933467865,
0.2314479500055313,
-0.0972728580236435,
0.3352680802345276,
0.007454320322722197,
0.2804443836212158,
-0.2322322279214859,
0.47913408279418945,
0.436694473028183,
-0.08285664767026901,
-0.08565697073936462,
0.3490239381790161,
-0.00019123910169582814,
0.14370164275169373,
-0.29006680846214294,
0.3641577363014221,
0.257743775844574,
0.030646812170743942,
-0.36607232689857483,
0.40808820724487305,
-0.07769589126110077,
-0.2956124544143677,
0.1657359004020691,
-0.06378134340047836,
-0.2206016331911087,
0.08950036764144897,
0.384433776140213,
0.1762349009513855,
-0.26836684346199036,
-0.30381959676742554,
0.4964548647403717,
-0.41443073749542236,
0.10831376165151596,
0.18468263745307922,
0.11753302812576294,
0.2374451458454132,
-0.2714686095714569,
-0.03474292904138565,
-0.2659750282764435,
0.42988893389701843,
-0.01210604328662157,
0.2181839644908905,
-0.12914888560771942,
-0.6867486238479614,
-0.5531556606292725,
-0.0845080092549324,
0.1302640587091446,
-0.41165122389793396,
-0.06050953269004822,
-0.002757683862000704,
-0.10746777802705765,
-0.03688761591911316,
0.12741562724113464,
0.49850741028785706,
0.03413046523928642,
-0.35686397552490234,
0.8431399464607239,
-0.06917726993560791
] |
6,820,111 |
Clinical and biochemical effects of EHDP in Paget's disease of bone: patterns of response to initial treatment and to long-term therapy.
|
Siris E S ES, Canfield R E RE, Jacobs T P TP, Stoddart K E KE, Spector P J PJ
|
Metabolic bone disease & related research . Vol. 3, No. 4-5, 1981
|
Studies regarding the efficacy of EHDP in the treatment of Paget's disease of bone conducted at our institution are described. An initial placebo-controlled clinical trial established that doses of 5 mg/kg/day for 6 months produced symptomatic improvement and a 50% lowering of serum alkaline phosphatase and urinary hydroxyproline. A subsequent study indicated that the biochemical suppression was maintained during the ensuing 6 months without therapy. Current results of long-term intermittent EHDP treatment in 40 patients studied for 5-8 years demonstrate that a small minority of individuals experience a sustained remission after a single six-month course of therapy, while a majority require repeated courses of 5 mg/kg/day for 6 of every 12 months to maintain their initial improvement. Data are also presented describing the successful use of EHDP at a dose of 20 mg/kg/day for 1 of every 4 months in patients refractory to conventional low doses of therapy. The possible role of parathyroid hormone in the expression of Paget's disease is also discussed, and recommendations regarding the pharmacologic management of patients with this disorder are provided.
|
https://pubmed.ncbi.nlm.nih.gov/6820111/
|
[
"Clinical Trial",
"Journal Article"
] |
6820111
|
[
0.2693968415260315,
3.0328330993652344,
-1.8186545372009277,
-1.8563660383224487,
0.18485398590564728,
0.2627074122428894,
0.21711072325706482,
0.4079154431819916,
-1.1239244937896729,
-0.3906753361225128,
0.19607149064540863,
2.148407459259033,
-0.15314705669879913,
1.1397879123687744,
-0.9526729583740234,
-0.08390521258115768,
-0.882056474685669,
0.0007256340468302369,
0.7139523029327393,
-1.327347993850708,
0.5648477673530579,
-0.8384771943092346,
0.4627373516559601,
0.20113596320152283,
0.28681063652038574,
-0.8122668862342834,
-1.1493042707443237,
1.9533432722091675,
0.33493706583976746,
1.2491693496704102,
-0.17317314445972443,
-0.0649990439414978,
0.8055915236473083,
0.23974674940109253,
0.16465269029140472,
0.1661493331193924,
1.3079111576080322,
0.15637734532356262,
-0.777010440826416,
0.4942789375782013,
-0.030100142583251,
0.22429993748664856,
-0.8229423761367798,
-1.2386125326156616,
0.3736366033554077,
1.2851263284683228,
0.1627849042415619,
-0.06432972848415375,
1.0364640951156616,
0.16758446395397186,
-0.4025096893310547,
1.0398929119110107,
-1.7562676668167114,
-0.20718172192573547,
2.2919163703918457,
0.8012295961380005,
0.2978670597076416,
0.1714911013841629,
1.3819020986557007,
0.012059718370437622,
-0.10746879875659943,
0.8815136551856995,
-0.6979653239250183,
0.7632665038108826,
-0.4410175085067749,
-0.14259551465511322,
-0.3070538341999054,
0.7618502974510193,
-0.8408399224281311,
0.4220218360424042,
-0.4945870637893677,
-0.07045914977788925,
0.5084940791130066,
0.28295648097991943,
0.45288264751434326,
0.5368940830230713,
-0.6099461317062378,
0.5338783264160156,
0.2421029508113861,
-0.31338033080101013,
-0.38632631301879883,
-0.14427891373634338,
0.18085134029388428,
-0.12860825657844543,
0.33325642347335815,
0.41932374238967896,
-0.5046845078468323,
-0.2972224950790405,
0.23532313108444214,
-0.6427067518234253,
0.401203989982605,
-0.6949501037597656,
-1.074143409729004,
0.3055388629436493,
-0.7399073839187622,
0.5301656723022461,
-0.05263194814324379,
-0.06735407561063766,
-0.5782408714294434,
-0.5136455297470093,
0.4043799340724945,
-0.07542359083890915,
-0.4917091727256775,
0.11071546375751495,
-0.7349662184715271,
-0.037116266787052155,
-0.4326817989349365,
-0.7707570791244507,
-0.43367502093315125,
-0.9966167211532593,
-0.27399682998657227,
-0.47438254952430725,
0.2846123278141022,
-0.019367745146155357,
0.7591846585273743,
0.464703232049942,
-0.043226778507232666,
-0.3391314446926117,
-0.17519816756248474,
0.2859099507331848,
0.8039657473564148,
0.6907194256782532,
-0.2469293475151062,
-0.32711082696914673,
-0.6252344250679016,
-0.8349315524101257,
0.6310210824012756,
0.14242087304592133,
-0.18916219472885132,
-0.6568427085876465,
-0.7099682688713074,
0.19131521880626678,
0.1000085398554802,
-0.6957722306251526,
-1.4225081205368042,
-0.5167141556739807,
0.04555118456482887,
0.9984959959983826,
0.22617273032665253,
-0.7748630046844482,
-0.11815246194601059,
0.25364336371421814,
-0.41857078671455383,
0.027929771691560745,
-1.4523983001708984,
0.2458607703447342,
-0.6154282093048096,
0.15252014994621277,
-0.3673820197582245,
-0.24088241159915924,
0.6382333040237427,
0.5060973763465881,
0.23985031247138977,
0.18334583938121796,
0.028286948800086975,
0.07663898169994354,
-0.10397887229919434,
0.19859924912452698,
0.4699780344963074,
-0.3320015072822571,
0.34405645728111267,
-0.6467975378036499,
0.4353850185871124,
-0.6212354302406311,
0.5981298089027405,
0.10882075875997543,
-0.34686416387557983,
-0.27440765500068665,
0.2281648963689804,
0.21390129625797272,
-0.3686828315258026,
0.14117257297039032,
0.12212097644805908,
0.21743406355381012,
-0.3017774522304535,
-0.16247135400772095,
0.722048819065094,
-0.3684900999069214,
0.7379936575889587,
0.34620893001556396,
-0.6759035587310791,
-0.1312105357646942,
-0.06918413937091827,
-0.34174850583076477,
0.05391727760434151,
-0.47621428966522217,
-0.48086050152778625,
0.3150111436843872,
-0.11539652943611145,
0.06578221172094345,
0.25568416714668274,
0.03781445696949959,
-0.36711254715919495,
0.622044026851654,
0.43801242113113403,
-0.051436834037303925,
-0.0024398902896791697,
0.16858071088790894,
0.29443076252937317,
-0.39562419056892395,
-0.12929031252861023,
0.21641993522644043,
0.25613030791282654,
0.9222680330276489,
0.22220811247825623,
-0.16711744666099548,
-0.05699172243475914,
0.3346899151802063,
-0.16577382385730743,
0.7477847933769226,
0.49268510937690735,
0.06171202287077904,
0.016212811693549156,
0.2786526083946228,
-0.3456435203552246,
-0.01172973494976759,
0.262307345867157,
-0.13118630647659302,
-0.22075356543064117,
-0.14408373832702637,
-0.06133841723203659,
-0.20654238760471344,
-0.07422417402267456,
0.14395298063755035,
-0.3654896914958954,
-0.12811464071273804,
0.05426253378391266,
0.10089131444692612,
-0.286274790763855,
-0.23826225101947784,
-0.1027781218290329,
0.4578135311603546,
0.17174594104290009,
0.0428016223013401,
-0.020913109183311462,
-0.32820796966552734,
0.36555784940719604,
0.34540772438049316,
-0.3498627841472626,
0.32291164994239807,
0.27146318554878235,
-0.6074120402336121,
-0.05393525958061218,
-0.3131050765514374,
0.1188156008720398,
0.2772699296474457,
-0.2889482080936432,
0.29983994364738464,
0.25081145763397217,
-0.02952512912452221,
-0.24507614970207214,
-0.3508540689945221,
-0.018751254305243492,
-0.10308962315320969,
0.3785686790943146,
-0.15441298484802246
] |
6,820,183 |
Diet versus average Danish food in insulin-dependent diabetes mellitus. An evaluation during treatment with an artificial betacell.
|
Krarup-Hansen A A, Lauritzen T T, Christiansen J S JS, Svendsen P A PA, Deckert T T
|
Scandinavian journal of clinical and laboratory investigation . Vol. 42, No. 8, 1982 Dec
|
Ten randomly selected insulin-dependent diabetics with minimal betacell function were studied during treatment with an artificial betacell during two consecutive 24-hour periods. Patients were randomly served diabetic diet for one 24-hour period and average Danish food during the other 24-hour period. No significant (P greater than 0.05) difference was found between the mean blood glucose concentrations, nor insulin requirements on average Danish food compared to diet. However, the mean amplitude of glucose excursions was significantly higher on average Danish food than on diabetic diet (median 3.6 versus 2.7 mmol/l, P less than 0.05). Thus insulin-dependent patients not following their diabetes diet will show increased blood glucose fluctuations.
|
https://pubmed.ncbi.nlm.nih.gov/6820183/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6820183
|
[
0.9729099869728088,
1.7696623802185059,
-2.601966381072998,
-2.923095703125,
0.620020866394043,
0.5989614129066467,
0.5163424611091614,
-1.5345579385757446,
0.49754253029823303,
-0.5555981993675232,
1.4502224922180176,
1.7573440074920654,
-0.840498685836792,
0.13998915255069733,
-0.9868908524513245,
-0.2072347104549408,
-0.9314975142478943,
-0.5234538912773132,
0.7869887351989746,
-2.883674144744873,
0.5783952474594116,
-0.006666954606771469,
-2.025226593017578,
-0.3241111934185028,
0.3888241946697235,
-0.5918771624565125,
0.2649646997451782,
1.971454381942749,
-0.6246989965438843,
1.7747101783752441,
0.4359941780567169,
-0.422840416431427,
-1.0060944557189941,
0.13253216445446014,
1.8090869188308716,
0.7987954020500183,
1.5889593362808228,
-1.0868909358978271,
-0.7858184576034546,
0.6024655103683472,
1.319841742515564,
0.3917349874973297,
1.3487578630447388,
0.5317606925964355,
1.315611720085144,
-0.11792097240686417,
1.2063168287277222,
0.25581085681915283,
0.3539838492870331,
1.550256609916687,
0.4778737425804138,
1.8964415788650513,
-2.502870559692383,
0.16705690324306488,
2.0755419731140137,
2.3586485385894775,
0.8727418780326843,
-0.008788680657744408,
1.0387197732925415,
-1.079424262046814,
0.46555379033088684,
0.20165607333183289,
-0.8600943088531494,
-0.01466371864080429,
-1.5453851222991943,
-1.9640791416168213,
0.8056746125221252,
-0.1075737327337265,
-0.7914093136787415,
-0.36419251561164856,
-0.9392344355583191,
-0.7109308242797852,
0.33380356431007385,
-0.7893474698066711,
0.7600025534629822,
0.19994300603866577,
-0.13228283822536469,
1.8534671068191528,
0.6847187876701355,
0.813918948173523,
-0.8474360108375549,
-0.5586709976196289,
0.1575666069984436,
0.8318566679954529,
0.3953855335712433,
0.5499641299247742,
-0.635726273059845,
-0.019665194675326347,
0.7334880828857422,
-1.1309648752212524,
0.11436251550912857,
-0.8818911910057068,
-0.21531949937343597,
-0.30589503049850464,
-0.8974276185035706,
0.3516484797000885,
0.2984539270401001,
-0.09384357929229736,
0.47264862060546875,
-0.284335732460022,
-0.35783353447914124,
0.13609041273593903,
-0.25506967306137085,
1.1195518970489502,
0.9667403101921082,
-0.35511958599090576,
0.41468802094459534,
-0.10149016976356506,
-2.0489113330841064,
-0.11200926452875137,
-0.18370608985424042,
-1.6467963457107544,
-0.32828062772750854,
-0.08691172301769257,
1.2787508964538574,
0.03959628567099571,
0.33087167143821716,
0.06102992221713066,
-0.02740899845957756,
-0.8571457862854004,
-0.7024375796318054,
-0.7604376077651978,
-0.148922860622406,
0.4063173830509186,
0.1271110326051712,
-0.8161430954933167,
-0.012594547122716904,
1.0396308898925781,
-0.9012612104415894,
-0.43202340602874756,
0.4493762254714966,
0.4291493594646454,
-0.743019163608551,
-2.014913320541382,
-1.2873731851577759,
-0.1736138015985489,
0.07084883749485016,
0.2680201530456543,
0.9638564586639404,
-0.49255800247192383,
0.0692964568734169,
-0.13078802824020386,
-0.8113496899604797,
0.23632757365703583,
-0.6027812361717224,
0.13034799695014954,
-0.22097298502922058,
-0.213306725025177,
-0.7327311038970947,
0.17575152218341827,
0.1313658207654953,
0.7036052346229553,
0.4113665223121643,
0.41347214579582214,
-0.6596804261207581,
-0.2145378738641739,
-0.3489398956298828,
0.0360250324010849,
-0.6243972778320312,
0.7108829617500305,
0.3839370608329773,
0.2550709843635559,
-0.6458550691604614,
-1.1022862195968628,
0.40403273701667786,
0.24000073969364166,
-0.3111248016357422,
0.3152625262737274,
0.09344284236431122,
0.11916206032037735,
-0.06447947770357132,
0.23920127749443054,
0.39818331599235535,
0.5088582634925842,
-0.4499092996120453,
-0.026957767084240913,
0.7537069320678711,
0.490933358669281,
0.8887094855308533,
0.02653706818819046,
-0.5226583480834961,
-0.12597636878490448,
0.24840664863586426,
-0.43662065267562866,
0.5622555017471313,
-0.20224304497241974,
-0.09988737106323242,
-0.09080048650503159,
0.3655066192150116,
-0.0191488154232502,
-0.3165864646434784,
0.2856622636318207,
-0.1528709977865219,
0.6320477724075317,
0.2691574990749359,
0.5167049765586853,
-0.5572306513786316,
0.3915421962738037,
0.38466233015060425,
0.13043580949306488,
0.5035978555679321,
-0.620090901851654,
0.023697098717093468,
0.9810997247695923,
-0.36152446269989014,
-0.7964773774147034,
-0.3669494390487671,
0.31174415349960327,
-0.575404703617096,
0.28476449847221375,
0.26513612270355225,
0.3350653648376465,
-0.5815455913543701,
0.5016080141067505,
-0.24730199575424194,
-0.3788190484046936,
-0.1342250555753708,
0.07859715074300766,
0.1147596463561058,
-0.3351394832134247,
-0.09971854835748672,
-0.4451931118965149,
0.38756856322288513,
-0.2029573917388916,
-0.5414819121360779,
-0.2848151922225952,
0.21887758374214172,
0.5944852232933044,
0.10873257368803024,
-0.20959220826625824,
-0.08121957629919052,
-0.3172898292541504,
-0.8550918102264404,
-0.45580366253852844,
0.0716068223118782,
-0.6955594420433044,
-0.10292394459247589,
0.15896643698215485,
-0.02653811313211918,
0.22497521340847015,
0.2622641623020172,
-0.6584950089454651,
-0.09621386229991913,
0.5003589987754822,
0.17815499007701874,
0.35863515734672546,
-0.2651542127132416,
0.31461474299430847,
0.18559810519218445,
0.17729176580905914,
-0.1511070281267166,
-0.5128488540649414,
0.27865007519721985,
0.4555467665195465,
-0.2620791494846344,
-0.19558405876159668
] |
6,820,504 |
The symptomatic and objective effects of nifedipine in combination with beta-blocker therapy in severe angina pectoris.
|
Jenkins R M RM, Nagle R E RE
|
Postgraduate medical journal . Vol. 58, No. 685, 1982 Nov
|
Nine patients with severe coronary artery disease and disabling angina receiving either regular metoprolol or oxprenolol, together with glyceryl trinitrate tablets as required for chest pain, were studied. Nifedipine 10 mg three times per day was compared to placebo in a double blind randomized control trial, using patient diary cards and exercise tests. The number of recorded episodes of angina during the placebo period of 15.0 +/- 2.1 (mean +/- s.e.m.) per patient per week was significantly reduced to 11.2 +/- 2.5 during the nifedipine period (P less than 0.05). Similarly, the recorded number of glyceryl trinitrate tablets consumed during the placebo period of 12.6 +/- 2.1 was significantly reduced to 9.1 +/- 2.0 tablets per patient per week during the nifedipine period (P less than 0.05). There was a statistically significant increase in both the duration of exercise to onset of chest pain (from 241 +/- 16.3 seconds on placebo to 306 +/- 38.4 seconds on nifedipine (P less than 0.05)) and the total work performed to the onset of chest pain during the nifedipine period compared to the control and placebo periods (P less than 0.05). There was a significant increase (P less than 0.05) in exercise time before the onset of appreciable ST depression (greater than 1 mm) on exercise testing during the nifedipine period (66.2 +/- 4.2 sec) compared to the control period (51.2 +/- 3.0 sec) and placebo periods (58.7 +/- 3.5 sec). Although nifedipine was generally well tolerated, one patient experienced a severe episode of angina whilst taking the drug, which required admission to hospital.
|
https://pubmed.ncbi.nlm.nih.gov/6820504/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6820504
|
[
-0.31814804673194885,
1.1377594470977783,
-1.3112998008728027,
-2.235482931137085,
0.7353532910346985,
0.9376847147941589,
1.3630934953689575,
-0.6461718082427979,
0.1483316719532013,
-0.12709097564220428,
-0.14048488438129425,
0.7997159957885742,
-0.36475417017936707,
0.11539105325937271,
0.15562860667705536,
-0.6490640044212341,
0.04863956943154335,
-0.5100558400154114,
0.8143672943115234,
-1.6466314792633057,
0.26734739542007446,
0.2735083997249603,
-1.1633270978927612,
-0.7705904245376587,
0.06178326904773712,
-0.0724373534321785,
-0.3842054009437561,
0.7951934337615967,
-0.05011465400457382,
1.490864872932434,
1.4563153982162476,
-0.5863955020904541,
0.6230416893959045,
0.11155463010072708,
-0.2510312497615814,
0.12905287742614746,
0.5214031934738159,
-0.196819007396698,
0.44098198413848877,
-0.6147483587265015,
0.8238613605499268,
0.665240466594696,
-0.36806055903434753,
0.16153627634048462,
1.1278274059295654,
-0.18429797887802124,
0.2865675687789917,
0.045987606048583984,
0.24430257081985474,
-0.1947823315858841,
-0.2080506831407547,
0.9036009907722473,
-0.7742653489112854,
-0.3560844361782074,
0.5890317559242249,
-0.5300692319869995,
0.7379299998283386,
0.50989830493927,
0.39193060994148254,
-0.3924671709537506,
-0.6550003290176392,
0.15926729142665863,
-0.16275207698345184,
-0.1856960505247116,
0.0905771553516388,
-0.7213709354400635,
0.2344997525215149,
0.5296031832695007,
-0.5220155119895935,
0.9583989381790161,
0.4007737338542938,
0.12315978854894638,
-0.05668768286705017,
-0.20271530747413635,
0.7845770716667175,
0.09255963563919067,
-0.7220266461372375,
1.1016346216201782,
0.4238409996032715,
0.6241168975830078,
-0.7148882746696472,
0.0075805215165019035,
0.48354560136795044,
-0.35084715485572815,
-0.0388776995241642,
0.3850180208683014,
-0.6455702781677246,
-0.697557270526886,
0.7939866781234741,
-0.7555395364761353,
-0.3454316556453705,
-0.40525421500205994,
-0.8743659853935242,
0.6703708171844482,
-0.6837603449821472,
0.4480254650115967,
0.04373444616794586,
-0.4189305305480957,
-0.4730912446975708,
-0.4146296977996826,
-0.17113471031188965,
-0.2581050992012024,
-0.10450712591409683,
0.45528098940849304,
0.08237626403570175,
-0.2898763418197632,
-0.11297987401485443,
-0.7956369519233704,
-0.6352127194404602,
-0.4421212375164032,
-0.1524456888437271,
-0.07135254144668579,
-0.08306077122688293,
-0.38253867626190186,
0.13740301132202148,
0.36930251121520996,
0.23328325152397156,
-0.29588931798934937,
-0.4280911684036255,
-0.7643751502037048,
0.0980643481016159,
0.4760691225528717,
-0.3394276201725006,
0.776931643486023,
-0.1117398738861084,
0.381204217672348,
0.11395266652107239,
0.44161632657051086,
-0.21338814496994019,
-0.24441610276699066,
-0.16772860288619995,
0.3245929181575775,
0.08695236593484879,
-0.5096018314361572,
-0.9534136056900024,
-0.5875450968742371,
-0.37518230080604553,
0.9080260396003723,
0.05252624303102493,
-0.3410564661026001,
-0.17324420809745789,
0.08428934961557388,
-0.24050679802894592,
-0.25342944264411926,
-0.8515652418136597,
0.09684305638074875,
-0.5162749290466309,
0.70563143491745,
-0.009576740674674511,
-0.2661847174167633,
-0.7512525916099548,
0.47131016850471497,
0.05812349170446396,
-0.2552635669708252,
-0.09733138978481293,
0.20774374902248383,
0.15010590851306915,
0.17392359673976898,
-0.04716852679848671,
0.21833962202072144,
0.4575035870075226,
0.12655101716518402,
-0.05403149873018265,
-0.05573950335383415,
0.20790371298789978,
0.1401652991771698,
-0.04695875197649002,
-0.18451879918575287,
0.19844721257686615,
0.008585747331380844,
-0.6000611186027527,
0.16596321761608124,
0.0626305565237999,
0.3317413330078125,
-0.35640767216682434,
0.18113362789154053,
0.009332445450127125,
0.08079355210065842,
0.13708160817623138,
0.11892754584550858,
0.034439727663993835,
-0.4632561206817627,
-0.10992725193500519,
0.007260884623974562,
-0.11502473056316376,
-0.21190235018730164,
0.007577584125101566,
-0.03355899825692177,
0.05925823003053665,
0.1984139084815979,
-0.13678057491779327,
0.38169214129447937,
-0.13466815650463104,
0.5180749297142029,
0.2004917711019516,
0.07718778401613235,
-0.534174919128418,
0.19673000276088715,
0.40431368350982666,
0.07418446987867355,
0.009502730332314968,
0.5384817719459534,
-0.081501804292202,
0.4722181558609009,
0.06477763503789902,
-0.3788902163505554,
-0.3219282329082489,
-0.05618916451931,
-0.19427143037319183,
0.15288132429122925,
0.23402440547943115,
0.1817002296447754,
-0.32090720534324646,
0.5398856997489929,
0.11915473639965057,
-0.2549515962600708,
-0.17626416683197021,
-0.296716570854187,
-0.201358363032341,
0.18691948056221008,
-0.052385903894901276,
-0.32525745034217834,
-0.07459752261638641,
-0.3563477694988251,
0.0012482833117246628,
-0.28961730003356934,
0.43451210856437683,
0.38435477018356323,
0.10461056232452393,
-0.026496009901165962,
-0.25859305262565613,
0.059924326837062836,
-0.3736152946949005,
0.051172833889722824,
0.09225422143936157,
-0.3802773654460907,
0.02453048713505268,
0.10919380187988281,
-0.06010394170880318,
0.21366296708583832,
-0.12573176622390747,
-0.6752720475196838,
-0.01130881067365408,
-0.3844020366668701,
0.1388562023639679,
0.0110410675406456,
0.029774624854326248,
0.23920764029026031,
-0.06062733754515648,
-0.14492492377758026,
0.09739553928375244,
-0.21518409252166748,
-0.18923434615135193,
0.0034986569080501795,
-0.3695613741874695,
-0.011801986023783684
] |
6,821,012 |
A double blind controlled trial of Bencard house dust mite (Migen) hyposensitisation in Zambian asthmatics.
|
Buchanan D J DJ, Hillis A A, Williams P N PN
|
Medical journal of Zambia . Vol. 15, No. 1
|
A double blind controlled trial of Bencard HDM (Migen) for the prophylaxis of asthma in a group of Zambian asthmatics failed to show any benefit. The trial results suggest that asthmatics can benefit from regular supervision and the position of prophylactic and therapeutic medication.
|
https://pubmed.ncbi.nlm.nih.gov/6821012/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6821012
|
[
1.1435673236846924,
2.3896589279174805,
-0.6810839772224426,
-3.8810160160064697,
0.1980678290128708,
0.24051454663276672,
-1.2345991134643555,
2.494788646697998,
-1.9046639204025269,
-0.05007495358586311,
1.2639508247375488,
1.153448462486267,
-1.9439010620117188,
0.1947515606880188,
-0.11665143072605133,
-0.08583307266235352,
0.5477655529975891,
0.9237228035926819,
1.425204873085022,
-1.9964699745178223,
0.27878788113594055,
0.15078455209732056,
0.04400579258799553,
-0.029994992539286613,
-0.08273103833198547,
-0.040286507457494736,
0.2233438491821289,
3.060856819152832,
0.775104820728302,
0.1935391128063202,
0.05206400156021118,
-1.6588155031204224,
0.8540893793106079,
-0.08851562440395355,
-0.6489142775535583,
0.7189062833786011,
0.6369592547416687,
-0.1391213834285736,
-0.3328820466995239,
-0.28686684370040894,
0.026623912155628204,
0.4201635718345642,
0.6341234445571899,
-0.7459767460823059,
1.9324082136154175,
0.4709353446960449,
0.22255368530750275,
-0.3722960650920868,
0.8520219326019287,
-0.8184374570846558,
-0.2868945598602295,
1.5032527446746826,
0.19686202704906464,
-1.163280963897705,
3.8282182216644287,
-0.15999116003513336,
0.8284289836883545,
0.9045943021774292,
1.3847098350524902,
1.6129025220870972,
0.7180144786834717,
-2.1101861000061035,
1.1778002977371216,
1.810084342956543,
-0.6518731117248535,
0.3831804096698761,
0.9381018280982971,
0.4393738806247711,
-0.18347710371017456,
0.35494303703308105,
-0.8222206830978394,
-0.9366243481636047,
-1.0169047117233276,
0.3799976110458374,
-0.683337926864624,
1.1510400772094727,
-0.2557477653026581,
0.5108649134635925,
0.6983070969581604,
0.24853435158729553,
0.54428631067276,
0.41568905115127563,
-0.0995500460267067,
-0.3281737267971039,
-2.2192163467407227,
0.17951755225658417,
-0.7411566972732544,
0.13965538144111633,
-0.7541558146476746,
-0.8978543281555176,
1.032901406288147,
-0.34902098774909973,
-0.32232147455215454,
1.736648440361023,
-1.2566075325012207,
0.04887281358242035,
-0.5878542065620422,
0.26120635867118835,
0.11768116056919098,
-0.39184463024139404,
0.6643165946006775,
-0.0947914719581604,
0.6976338028907776,
0.5679898858070374,
-0.22421157360076904,
0.10632868111133575,
-0.5679994225502014,
-1.0332965850830078,
-0.5314515829086304,
-0.3832354247570038,
1.1240222454071045,
-0.03462519124150276,
0.4777529835700989,
0.07158853113651276,
0.639902651309967,
-0.18684685230255127,
0.6216752529144287,
0.46193239092826843,
-0.6483511924743652,
1.5190598964691162,
-0.3770665228366852,
1.990146517753601,
0.08474145829677582,
0.5162707567214966,
-0.5333251357078552,
0.12155614793300629,
-0.05632871389389038,
0.28545334935188293,
-0.67361980676651,
-0.4891611337661743,
0.04534244164824486,
0.2298462688922882,
0.3862488269805908,
-1.206417441368103,
-2.003856658935547,
-0.19625870883464813,
0.5138338208198547,
0.47412538528442383,
0.4309248924255371,
-0.05464211851358414,
0.12445053458213806,
0.7155541181564331,
-0.013358358293771744,
0.021643944084644318,
-0.7382625937461853,
-0.672364354133606,
0.7363091111183167,
0.19777469336986542,
0.2414255142211914,
-0.07400395721197128,
0.2037058025598526,
0.9640337824821472,
0.3690003752708435,
-0.22679142653942108,
-0.1771632432937622,
1.0937672853469849,
0.0030091458465903997,
-0.751335084438324,
0.5067721605300903,
-0.17170484364032745,
0.17382599413394928,
-1.1593552827835083,
0.22026284039020538,
-0.8141141533851624,
0.36990416049957275,
0.37227946519851685,
-0.18235963582992554,
0.40733250975608826,
-0.17634586989879608,
-0.9622149467468262,
-0.8559554219245911,
-0.5376279950141907,
-0.9914283752441406,
0.4761406481266022,
-0.04045557975769043,
-0.25857701897621155,
0.696698784828186,
-0.760790228843689,
-0.06250302493572235,
-0.20853076875209808,
0.26333001255989075,
0.39583778381347656,
-0.7221720814704895,
0.026863720268011093,
-0.3722142279148102,
-0.06049550324678421,
0.3747836649417877,
0.16190798580646515,
0.04220883548259735,
0.09355318546295166,
-0.1446659415960312,
0.011351224035024643,
-0.5344157814979553,
0.2313242256641388,
0.8053215742111206,
-0.1296350061893463,
-0.18228097259998322,
-0.08585689216852188,
0.9283459782600403,
-0.43738698959350586,
0.7719451189041138,
-0.34567785263061523,
0.02768702805042267,
0.04672419652342796,
-0.12087323516607285,
0.44480448961257935,
-0.5412658452987671,
-0.12345478683710098,
0.07600928097963333,
-0.051082853227853775,
0.44022372364997864,
-0.6708704829216003,
-0.16752974689006805,
-0.15194758772850037,
0.28357189893722534,
0.12388084083795547,
0.3739219605922699,
0.7919637560844421,
-0.2460770457983017,
-0.0837448388338089,
-0.3246223032474518,
0.5384628772735596,
-0.18623121082782745,
0.1188434287905693,
-0.30294108390808105,
0.029296258464455605,
0.27907758951187134,
0.015180590562522411,
0.5570996999740601,
0.05168428272008896,
-0.2827337980270386,
0.32522064447402954,
-0.05935114249587059,
-0.7590147852897644,
-0.07083766907453537,
0.04657961055636406,
-0.26808175444602966,
0.32605472207069397,
-0.4396930932998657,
0.6921940445899963,
0.0706821009516716,
-0.8925809264183044,
-0.42276015877723694,
-0.6260759830474854,
-0.20607532560825348,
-0.6203697323799133,
-0.5092878341674805,
-0.26798856258392334,
0.1988672912120819,
0.0363142155110836,
0.025125976651906967,
0.0021300185471773148,
-0.10929030179977417,
0.02233307622373104,
0.004675308708101511,
-0.5805395841598511
] |
6,821,197 |
A comparison between 2% and 4% sodium cromoglycate eye drops in the treatment of vernal keratoconjunctivitis.
|
El Hennawi M M
|
Current eye research . Vol. 2, No. 11
|
Two per cent and 4% solutions of sodium cromoglycate eye drops were compared in patients with bilateral vernal keratoconjunctivitis. No difference in efficacy between the two solutions could be detected on the analysis of diary card scores or clinical assessments. The opinions of efficacy and treatment preferences recorded by patients and clinician at the end of the trial were very similar for each solution. Side effects were generally minor, usually relating to stinging following application of the eye drops.
|
https://pubmed.ncbi.nlm.nih.gov/6821197/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6821197
|
[
-0.5955262780189514,
1.9444888830184937,
-2.640779495239258,
-2.7322356700897217,
-0.9389148354530334,
-0.6956253051757812,
-0.09821946918964386,
-0.28578412532806396,
-0.786421000957489,
0.1101985052227974,
0.7349153757095337,
2.4064934253692627,
-0.748690128326416,
1.0688556432724,
-0.28064724802970886,
-0.34010228514671326,
0.04008684307336807,
-0.13358604907989502,
2.0578131675720215,
-1.4415603876113892,
-0.35734376311302185,
0.5418909192085266,
-0.11916599422693253,
0.020290639251470566,
0.18211114406585693,
-0.5143265128135681,
-0.22511661052703857,
1.5718183517456055,
-0.8897279500961304,
1.1280412673950195,
-1.6580939292907715,
-0.981560230255127,
0.1527063101530075,
0.012295663356781006,
0.16700325906276703,
-1.4637861251831055,
0.6970070600509644,
1.0397024154663086,
-0.383378267288208,
0.1737978160381317,
1.3250269889831543,
0.059033166617155075,
-0.6319764852523804,
-0.6532421708106995,
1.2185101509094238,
0.4807194769382477,
-0.07208826392889023,
0.7862727046012878,
0.12457998096942902,
0.594231367111206,
-0.822363555431366,
0.4243645668029785,
-0.617824912071228,
0.6993016004562378,
1.6848938465118408,
0.3200550377368927,
0.8315215706825256,
1.4292765855789185,
0.7536565065383911,
0.20987750589847565,
0.09221265465021133,
-0.8462870121002197,
0.38679277896881104,
0.34729817509651184,
-0.7096765637397766,
-0.18264363706111908,
-0.37899160385131836,
-1.001093864440918,
-0.6877784132957458,
0.3322778046131134,
-1.2003415822982788,
0.14131426811218262,
-0.39578357338905334,
0.2959837317466736,
1.115439534187317,
-0.9019815325737,
0.3112214207649231,
-0.444405198097229,
-0.5615202784538269,
-0.16240194439888,
-0.9108697772026062,
-0.45501708984375,
-0.2138032764196396,
-0.3361314535140991,
-0.05512576550245285,
0.35531264543533325,
-1.1021130084991455,
0.20017121732234955,
-0.37888428568840027,
-1.255232334136963,
-0.9928057193756104,
-0.325980544090271,
-1.1002473831176758,
1.1181859970092773,
0.025460345670580864,
0.9943485856056213,
0.2584027945995331,
-0.06377588957548141,
-0.8928520679473877,
-0.17701250314712524,
0.2149237096309662,
-0.003221530932933092,
-0.15099237859249115,
0.0900702103972435,
-0.414837121963501,
-0.8755863904953003,
-0.14970415830612183,
-0.2935285270214081,
-0.600921094417572,
-1.288639783859253,
0.10834432393312454,
-0.8182232975959778,
-0.285870760679245,
-1.202465534210205,
0.2681322991847992,
0.8128159046173096,
0.5238388776779175,
-1.0034282207489014,
-0.4345199167728424,
0.8118962645530701,
0.5771039128303528,
-0.32834601402282715,
-0.005403926596045494,
1.178040862083435,
-0.5810436010360718,
0.6456061601638794,
0.3789677619934082,
0.6643881797790527,
-0.7052660584449768,
-0.6751861572265625,
-0.07714962214231491,
0.036836836487054825,
0.18686223030090332,
-0.28364628553390503,
-1.4844025373458862,
-0.38526982069015503,
0.5409625172615051,
0.9524214863777161,
-0.10170958191156387,
-0.22104007005691528,
0.2293819636106491,
0.4579007029533386,
-0.11394445598125458,
0.0867151990532875,
-0.7838329672813416,
-0.36760228872299194,
-1.1813360452651978,
0.6388186812400818,
-1.4807021617889404,
-0.306188702583313,
-0.05898042023181915,
0.03539101779460907,
0.5924927592277527,
-0.3393412232398987,
0.5577932596206665,
0.3840917944908142,
0.9119415879249573,
0.2060614824295044,
0.009734750725328922,
-0.2767765522003174,
0.4883618652820587,
-0.6358628273010254,
0.5958623886108398,
-1.1753058433532715,
0.1654014140367508,
-0.0037505964282900095,
-0.9015047550201416,
-0.4075697958469391,
-0.05014292150735855,
-0.6445451378822327,
-0.9668611288070679,
-0.17977553606033325,
0.1855573207139969,
1.000274419784546,
0.1108427569270134,
-0.05875423550605774,
0.683748185634613,
0.13235856592655182,
0.882820188999176,
-0.317382276058197,
0.18796679377555847,
-0.14775888621807098,
0.03856837376952171,
-0.04301295056939125,
-0.2385011464357376,
-0.43871697783470154,
-0.4114089012145996,
0.008274824358522892,
0.34440940618515015,
0.13177575170993805,
-0.5308448672294617,
0.09057791531085968,
0.34060919284820557,
0.07698944956064224,
0.6248650550842285,
-0.24512524902820587,
-0.7847524285316467,
-0.09546186774969101,
0.4340558648109436,
-0.11839387565851212,
0.6753162741661072,
0.6608986258506775,
-0.3932282328605652,
0.5068991780281067,
-0.6781793832778931,
-0.14792978763580322,
-0.1700485646724701,
-0.2929873466491699,
-0.3422687351703644,
0.4103729724884033,
0.44426092505455017,
-0.3299863636493683,
-0.2728544771671295,
0.39357990026474,
0.5878955125808716,
0.7614524364471436,
0.9394940137863159,
0.4823111295700073,
-0.41240498423576355,
-0.51201993227005,
-0.3891036808490753,
0.012124312110245228,
0.04179315268993378,
0.3293943703174591,
-0.12430097907781601,
0.23898501694202423,
0.21092543005943298,
0.2880774736404419,
-0.13784699141979218,
0.10959555953741074,
-0.5241888165473938,
-0.028963007032871246,
-0.22975456714630127,
-0.04876481741666794,
-0.6482518315315247,
-0.17192572355270386,
0.06407252699136734,
-0.1364993005990982,
-0.1312367171049118,
0.3640785217285156,
0.04466911777853966,
-0.4205123782157898,
0.11741193383932114,
0.5260234475135803,
0.18212838470935822,
-0.35213136672973633,
-0.17449133098125458,
-0.0075853681191802025,
-0.11839508265256882,
-0.05646149441599846,
-0.3937249481678009,
0.12840145826339722,
-0.009082549251616001,
0.4554007351398468,
-0.03438404202461243,
-0.33377015590667725
] |
6,821,438 |
Seventh nerve spasm: effect of modification of cholinergic balance.
|
Hughes E C EC, Brackmann D E DE, Weinstein R C RC
|
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery . Vol. 88, No. 4
|
The seventh cranial nerve spasms of the face and the eyelids, including essential blepharospasm, are usually intractable and sometimes disabling. Deanol acetamidobenzoate was compared with the anticholinergic orphenadrine for relief of these spasms. Deanol cured two of 16 (12%) subjects and improved a third. Orphenadrine was much more effective, improving the conditions of 16 of 26 (62%) subjects between 57% and 100%. A crossover double-blind experiment showed high significance over a placebo.
|
https://pubmed.ncbi.nlm.nih.gov/6821438/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6821438
|
[
0.2481716126203537,
-0.5948022603988647,
-1.8639328479766846,
-1.3287557363510132,
0.0586295984685421,
0.288453608751297,
0.5995655059814453,
0.457512766122818,
-0.4427100419998169,
-0.6043548583984375,
-0.6019926071166992,
2.4727377891540527,
-0.3983420133590698,
0.19262532889842987,
-0.057213764637708664,
0.8103309869766235,
-0.963667631149292,
0.301148921251297,
1.4329850673675537,
-1.8176921606063843,
2.135742664337158,
-0.09319040179252625,
-0.1341124176979065,
-1.0513596534729004,
0.47256022691726685,
-1.2962554693222046,
0.49156346917152405,
0.8344934582710266,
-0.13998550176620483,
1.3105851411819458,
-0.9741926193237305,
0.6381241083145142,
0.19218608736991882,
-0.3192906081676483,
0.18394878506660461,
0.5204057097434998,
-0.3708837926387787,
-0.027042752131819725,
0.2823549211025238,
0.28264811635017395,
-0.057813454419374466,
0.47790688276290894,
0.701592206954956,
0.36840227246284485,
0.5490037202835083,
0.9684005975723267,
0.1772383600473404,
0.7005050778388977,
0.8605926036834717,
-0.2064710408449173,
0.20463524758815765,
0.2293197065591812,
-0.017754675820469856,
0.28260019421577454,
1.770336389541626,
-0.7633362412452698,
0.869810163974762,
0.3643868565559387,
0.1258143037557602,
-0.5691904425621033,
0.8198090195655823,
-0.40980759263038635,
0.7854421138763428,
0.7321037650108337,
-0.7208700776100159,
-0.32031771540641785,
0.06137023866176605,
0.8287498354911804,
-0.9624888896942139,
0.7899013757705688,
-0.049234308302402496,
0.3262365460395813,
0.11918950825929642,
-0.08486144244670868,
0.6689288020133972,
-0.30053892731666565,
0.38424772024154663,
0.8938021063804626,
0.6313010454177856,
0.0008923256536945701,
-0.27037569880485535,
0.6420307159423828,
0.31974002718925476,
-0.20581211149692535,
-0.006510213483124971,
0.17007039487361908,
-0.7676056027412415,
-0.4509740173816681,
-0.1620558351278305,
-0.10429892688989639,
0.5912189483642578,
-0.466056227684021,
-1.5366785526275635,
0.22882692515850067,
0.1807754933834076,
-0.30990517139434814,
-0.6054912209510803,
-0.5281848907470703,
-0.3593970239162445,
0.5797823667526245,
-0.01508876122534275,
0.5128666162490845,
-0.7990936040878296,
-0.0693328008055687,
-0.7751426696777344,
-1.0032626390457153,
-1.0171903371810913,
-0.6544373631477356,
0.2767280340194702,
-0.1768672913312912,
-0.04701719805598259,
0.3628588020801544,
-1.178850769996643,
-0.29195690155029297,
0.7786336541175842,
0.5380815863609314,
0.1981971263885498,
-0.5093576312065125,
0.006837500724941492,
-0.35545864701271057,
0.0813334658741951,
0.9588054418563843,
-0.12390958517789841,
0.4554542005062103,
0.35379183292388916,
-0.018833450973033905,
-0.06068773195147514,
0.25517404079437256,
-0.7040706276893616,
-0.26833590865135193,
-0.28555431962013245,
0.43173202872276306,
-0.4013381004333496,
-0.20185412466526031,
-1.2310632467269897,
-0.4477570950984955,
0.4568448066711426,
1.1497865915298462,
-0.06213873624801636,
-0.17312979698181152,
-0.6404742002487183,
0.6933013796806335,
-0.16207259893417358,
-0.35454267263412476,
-0.7459994554519653,
-0.16399377584457397,
0.04354364052414894,
0.9913033246994019,
-0.3309764862060547,
-0.1999337375164032,
0.33195722103118896,
0.24694903194904327,
0.34063372015953064,
-0.09750080853700638,
0.4149496853351593,
0.09646444022655487,
0.8842783570289612,
0.004798452369868755,
0.6847832202911377,
-0.07469423115253448,
0.04625844955444336,
-0.013073280453681946,
-0.020859695971012115,
-0.3783785104751587,
0.3520791232585907,
-0.04965905100107193,
0.4395398795604706,
-0.25202903151512146,
0.2774744927883148,
0.18094702064990997,
-0.5842206478118896,
0.6103710532188416,
-0.33759385347366333,
0.260711133480072,
-0.14448365569114685,
0.30072021484375,
0.6620266437530518,
0.2862204611301422,
0.897181510925293,
-0.14071552455425262,
-0.11173523217439651,
0.19178636372089386,
-0.500137448310852,
0.25188687443733215,
0.07357357442378998,
-0.38189610838890076,
-0.1896030753850937,
0.3239096999168396,
-0.3688717484474182,
0.48730161786079407,
0.29103711247444153,
0.030580634251236916,
-0.08957888185977936,
-0.40513041615486145,
0.6856890916824341,
-0.4312467873096466,
0.059296511113643646,
0.06603258848190308,
0.28648146986961365,
-0.7074967622756958,
-0.49936649203300476,
0.7619558572769165,
0.12126478552818298,
-0.2799907326698303,
-0.17121195793151855,
-0.04671313613653183,
-0.48844343423843384,
0.27217236161231995,
-0.5782390832901001,
0.44502440094947815,
0.3786415755748749,
0.3699871897697449,
-0.2861352860927582,
-0.21506719291210175,
0.29142841696739197,
0.3586752116680145,
-0.45430973172187805,
-0.20740917325019836,
-0.18601712584495544,
0.002224816707894206,
-0.017473800107836723,
0.06711762398481369,
-0.16893808543682098,
-0.051160410046577454,
-0.11987514793872833,
0.07661471515893936,
0.29120978713035583,
0.6663332581520081,
0.16340163350105286,
0.1952250748872757,
0.12747953832149506,
-0.052883513271808624,
-0.06484188139438629,
-0.04502313211560249,
0.2492697536945343,
0.3602413535118103,
0.40815451741218567,
-0.2645116448402405,
0.5238320827484131,
0.35412827134132385,
-0.21936945617198944,
0.004785525146871805,
-0.004452957306057215,
-0.08485391736030579,
0.17835058271884918,
-0.03297017887234688,
-0.3166828751564026,
0.00684367585927248,
-0.011435749009251595,
0.020635811612010002,
0.22812771797180176,
-0.17380192875862122,
-0.29789847135543823,
-0.2851286232471466,
-0.17298324406147003,
-0.10577620565891266
] |
6,821,435 |
Postoperative cholesteatoma: are claims for the canal wall down technique justified?
|
Smyth G D GD, Singh R R, Hassard T H TH
|
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery . Vol. 88, No. 4
|
To discover whether removal of the canal wall would reduce the incidence of postoperative cholesteatoma in tympanoplasty, the findings in staged, intact canal wall tympanoplasties were compared with those in staged, modified radical mastoidectomies with cavity obliteration and tympanoplasty. In all, cholesteatoma was considered totally removed at the first operation. The incidence of residual cholesteatoma was not significantly different in either group. It is concluded that staging in tympanoplasty for cholesteatoma is mandatory.
|
https://pubmed.ncbi.nlm.nih.gov/6821435/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6821435
|
[
0.23544679582118988,
0.2524009644985199,
-1.8394520282745361,
-2.7674343585968018,
-0.13912682235240936,
-0.6943972110748291,
-0.2804104685783386,
-0.28716039657592773,
-3.2436559200286865,
1.7832984924316406,
0.6606314182281494,
-1.4232184886932373,
-0.19430911540985107,
-2.4193060398101807,
0.5750492215156555,
-1.349711298942566,
1.6983728408813477,
2.056816816329956,
-1.121338963508606,
-1.108165979385376,
1.028878927230835,
-2.3591651916503906,
-2.30830454826355,
-1.2299551963806152,
0.8458403944969177,
-0.5473169684410095,
0.47918644547462463,
0.6064780354499817,
-0.25115272402763367,
0.9519044756889343,
0.34069958329200745,
0.8911901712417603,
1.2772401571273804,
0.38548171520233154,
-0.36703336238861084,
-0.25667575001716614,
-1.0631660223007202,
0.67348712682724,
-0.8525716662406921,
1.0183701515197754,
-0.13381178677082062,
-0.6837506890296936,
-0.14898009598255157,
0.49286964535713196,
-0.0598064586520195,
-0.24710297584533691,
-0.05237891897559166,
0.3359356224536896,
0.814775288105011,
0.6740975379943848,
-0.5740735530853271,
-0.3189127743244171,
0.09257189184427261,
-1.2179675102233887,
0.44559580087661743,
0.6156827807426453,
-0.27231764793395996,
0.5900219678878784,
0.3434601426124573,
-1.4131453037261963,
1.821150779724121,
0.7096894979476929,
-0.13816387951374054,
0.24758382141590118,
0.2030385434627533,
0.3987855613231659,
0.09536127746105194,
1.1475111246109009,
-0.23594458401203156,
-0.22336898744106293,
0.9052577614784241,
0.18920014798641205,
-0.8083670735359192,
1.2333534955978394,
0.24318130314350128,
1.2775877714157104,
0.1912495493888855,
0.7899395823478699,
0.1316142976284027,
-0.6133436560630798,
1.619927167892456,
0.019162852317094803,
-0.7426352500915527,
1.0007437467575073,
-0.29485243558883667,
-0.30567458271980286,
-1.5754053592681885,
-2.8761720657348633,
2.4806535243988037,
-1.5256181955337524,
0.905349612236023,
-0.4599251449108124,
-1.8583754301071167,
0.4692316949367523,
0.06434935331344604,
-0.2401852160692215,
0.5126867294311523,
-0.292202353477478,
-0.2080494463443756,
-0.9513039588928223,
1.4738258123397827,
-0.8139098882675171,
-0.23176346719264984,
-0.6252016425132751,
0.8234960436820984,
-1.8604681491851807,
-0.6766872406005859,
-0.7735008001327515,
-0.5256777405738831,
-1.0455100536346436,
0.46543198823928833,
-0.9120025038719177,
-1.2743204832077026,
-1.0080510377883911,
0.5685341358184814,
1.3238786458969116,
0.12370109558105469,
1.510367512702942,
-0.02475796639919281,
0.04269524663686752,
0.024654662236571312,
0.17662273347377777,
0.3748614490032196,
1.1234638690948486,
-1.0159938335418701,
0.5648191571235657,
0.6281304955482483,
0.5853956341743469,
0.2721072733402252,
0.5504042506217957,
-0.14024651050567627,
0.5734148621559143,
-0.7498635649681091,
-0.6179320812225342,
-1.1020832061767578,
0.5750991702079773,
0.39526599645614624,
0.8484447598457336,
-0.09829027205705643,
-0.6260125041007996,
1.2548913955688477,
-0.19180957973003387,
-0.7023379802703857,
-0.562100350856781,
-1.5819239616394043,
-1.4157887697219849,
0.5422242879867554,
0.7755683660507202,
-1.1646374464035034,
0.0021222957875579596,
0.14854839444160461,
0.160027414560318,
0.15126433968544006,
-0.3850093185901642,
0.3971937596797943,
-0.1513369083404541,
1.017580270767212,
-0.6932538747787476,
-0.15117748081684113,
-0.28154414892196655,
-0.0014329522382467985,
-0.015050486661493778,
0.31148043274879456,
0.4284552335739136,
0.5626267790794373,
-0.14709432423114777,
-0.19267509877681732,
-0.5327592492103577,
-0.18601036071777344,
-0.010093535296618938,
-0.4428492486476898,
0.17127129435539246,
0.5163037180900574,
-0.8422824144363403,
-0.6363967061042786,
-0.5850805044174194,
0.3169788420200348,
0.5592103600502014,
-0.08576777577400208,
-0.2323186844587326,
-0.020923884585499763,
-0.2288062572479248,
-0.28891074657440186,
1.2160100936889648,
-0.06548619270324707,
0.5424135327339172,
-0.39259976148605347,
-1.2251651287078857,
0.031209969893097878,
0.5720670819282532,
0.30963924527168274,
-0.2146151214838028,
-0.9525711536407471,
0.31547677516937256,
-0.088295578956604,
-0.11300530284643173,
-0.05552376061677933,
0.03269817680120468,
0.5269381999969482,
0.05594883859157562,
-0.0021265798714011908,
0.587780237197876,
0.11702583730220795,
0.1319407820701599,
-0.16115836799144745,
-0.39907699823379517,
-0.012415008619427681,
0.5849261283874512,
-1.3180385828018188,
0.1386539191007614,
-0.3612334430217743,
0.006664976477622986,
0.007944672368466854,
0.5580726265907288,
0.3593164384365082,
0.053017012774944305,
-0.07766791433095932,
0.4067583978176117,
-0.5617380738258362,
0.49517348408699036,
0.5027108192443848,
-0.036384329199790955,
-0.0337039940059185,
-0.8253691792488098,
-0.1609780341386795,
-0.14282535016536713,
0.13052862882614136,
-0.35822081565856934,
-0.6376051902770996,
-0.027280177921056747,
-0.11559723317623138,
-0.5224190950393677,
-0.504905104637146,
0.1761365383863449,
0.03712278977036476,
0.1994166076183319,
0.41365545988082886,
-0.4111953377723694,
-0.16887226700782776,
0.04527200758457184,
0.04609664902091026,
-0.239603653550148,
-0.588474690914154,
-0.3725373148918152,
-0.036519598215818405,
-0.09609752148389816,
0.02149091847240925,
-0.15737080574035645,
-0.172551229596138,
-0.712568998336792,
0.07348150759935379,
-0.4250781834125519,
-0.04019013047218323,
0.5385063290596008,
0.29656288027763367,
0.12664112448692322
] |
6,821,615 |
Effect of beta adrenergic blockade on thallium-201 myocardial perfusion imaging.
|
Hockings B B, Saltissi S S, Croft D N DN, Webb-Peploe M M MM
|
British heart journal . Vol. 49, No. 1, 1983 Jan
|
Nine patients with stable angina (group 1) underwent maximal treadmill stress testing and thallium-201 (201T1) myocardial scintigraphy after intravenous propranolol hydrochloride, and after placebo. Though seven of the nine patients exercised longer after propranolol than after placebo, this difference did not reach statistical significance. Propranolol, however, significantly reduced the mean maximum rate pressure product. Comparison of the perfusion scans on and off propranolol showed that in 36 out of 90 of the myocardial segments recorded (nine patients, five segments scanned twice per patient), only one of the scans showed a defect. In 24 out of 36 of these the propranolol scan was negative, the defect appearing in the placebo scan. Defects present on both scans but differing significantly in size occurred in 22 out of 54 view pairs (nine patients, three views after exercise and three views after redistribution on propranolol and on placebo), and in 19 of these the smaller defect was seen in the propranolol scan. In one of the nine patients, the propranolol scan was normal (false negative), whereas defects corresponding to angiographically proven coronary artery lesions were seen on the placebo scan. Six patients (group 2) were maximally exercised after propranolol and then re-exercised to the same rate pressure product on placebo. Again 16 out of 60 of the segment pairs disagreed and in 10 of these the unmatched defect was present on the placebo scan. In 10 out of 14 discrepant view pairs, the smaller defect occurred on the propranolol scan. Thus in patients taking propranolol, negative results do not exclude coronary artery disease, and perfusion defects (if present) though accurately reflecting the presence of disease may underestimate its true extent.
|
https://pubmed.ncbi.nlm.nih.gov/6821615/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6821615
|
[
-0.6457030773162842,
0.9787935614585876,
-0.7484270334243774,
-1.8118832111358643,
0.05020446330308914,
1.243941307067871,
0.2881140112876892,
-0.36799052357673645,
-1.6551320552825928,
0.7263491749763489,
-0.9399213194847107,
-0.6891453862190247,
-0.5262859463691711,
-0.07966320961713791,
-0.10489838570356369,
1.1541152000427246,
-0.7714790105819702,
0.07203652709722519,
0.7486647367477417,
-1.8873441219329834,
0.18574446439743042,
-0.33355826139450073,
-0.0004417150921653956,
-0.34052547812461853,
0.05870988219976425,
-1.0815085172653198,
0.9754345417022705,
0.17046698927879333,
-0.3707067668437958,
0.9862086176872253,
-0.34734830260276794,
-0.36120668053627014,
-0.35850298404693604,
0.24217987060546875,
0.6413137316703796,
-0.2961277961730957,
0.05931950733065605,
-1.128496527671814,
-0.6649189591407776,
-0.4294663071632385,
0.09410057216882706,
-0.11608696728944778,
-0.35518959164619446,
-1.5043909549713135,
1.757347583770752,
-0.29636430740356445,
0.9982740879058838,
0.04933294281363487,
-0.00011645297490758821,
-1.0208204984664917,
-0.42009997367858887,
0.1991683840751648,
-0.08533314615488052,
-0.03102605976164341,
0.4754420220851898,
0.6453032493591309,
1.2030017375946045,
0.7077717781066895,
0.6938163042068481,
0.5709254145622253,
0.06465607136487961,
-0.43959805369377136,
0.9371806383132935,
0.891817033290863,
0.8426762819290161,
-0.256105899810791,
-1.4439409971237183,
0.0031671675387769938,
-1.5719462633132935,
-0.27984917163848877,
0.3246731460094452,
-0.06699122488498688,
-0.18585607409477234,
-0.21785368025302887,
0.6481688618659973,
1.128576636314392,
-0.2225307673215866,
0.9874822497367859,
0.20263339579105377,
0.5460853576660156,
-0.12598833441734314,
-0.8139103055000305,
-0.9600529074668884,
0.7687327265739441,
0.518272340297699,
-0.08184493333101273,
-0.378708153963089,
-0.3367399275302887,
-0.044592924416065216,
-1.1263986825942993,
-0.9606855511665344,
-0.47941675782203674,
-1.0653541088104248,
1.4416484832763672,
-0.9704523682594299,
0.21080294251441956,
-0.5635814070701599,
-0.9345535039901733,
-0.16754111647605896,
-0.011186392046511173,
-0.42443838715553284,
-0.49273985624313354,
0.5923335552215576,
0.25385791063308716,
-0.04258837178349495,
0.2155054360628128,
-0.7111218571662903,
-0.6895357966423035,
-1.4331446886062622,
-1.0921413898468018,
0.4281294643878937,
-0.4471534788608551,
-0.6575930714607239,
-0.29831647872924805,
0.44532257318496704,
-0.31982675194740295,
-0.1558249443769455,
0.1090625450015068,
-0.2761596143245697,
0.13239997625350952,
-0.8906277418136597,
0.7156956791877747,
0.46750810742378235,
0.1814320981502533,
0.4883778691291809,
-0.15407951176166534,
0.9518183469772339,
-0.026347313076257706,
0.07218064367771149,
-0.1864849179983139,
-0.9102373719215393,
-0.08689147979021072,
0.21129558980464935,
-0.3593190908432007,
-1.5171619653701782,
0.7351027131080627,
-0.13796374201774597,
0.405100017786026,
-0.2894745469093323,
-0.14037343859672546,
0.21214406192302704,
0.7139769792556763,
-0.4125973582267761,
0.4615531265735626,
-0.8686871528625488,
0.46759986877441406,
-0.6570240259170532,
0.8150221705436707,
-0.11061979085206985,
-0.01760816015303135,
0.19583329558372498,
0.26093071699142456,
-0.2829298973083496,
-0.6473888754844666,
-0.325988233089447,
0.4838521182537079,
0.07043218612670898,
-0.10276182740926743,
0.3795154392719269,
0.126058429479599,
0.3385504484176636,
-0.4296569526195526,
0.20979872345924377,
0.09909836202859879,
0.8972986936569214,
-0.6406165361404419,
0.20780624449253082,
-0.4322766959667206,
0.5450441241264343,
-0.35581499338150024,
-0.6935924887657166,
-0.12178366631269455,
0.17157864570617676,
0.41319844126701355,
-0.4383084177970886,
0.2918557822704315,
0.5690363049507141,
0.41832175850868225,
0.8159565925598145,
-0.21779902279376984,
-0.18851810693740845,
0.1906101405620575,
-0.49450570344924927,
0.05318126082420349,
-0.2882903814315796,
0.21762552857398987,
-0.0009055195841938257,
-0.5409622192382812,
0.11075960099697113,
0.4974944293498993,
-0.05740606039762497,
0.3874858617782593,
0.19877997040748596,
0.01437575276941061,
0.7091418504714966,
0.4840940535068512,
-0.24567535519599915,
0.26985907554626465,
0.5340314507484436,
-0.31159350275993347,
0.0068809716030955315,
-0.020917721092700958,
0.24272175133228302,
0.6038260459899902,
0.1238446906208992,
0.24112287163734436,
-0.49345865845680237,
-0.14558640122413635,
-0.3690595030784607,
0.09727906435728073,
-0.020085621625185013,
0.224852055311203,
0.056524816900491714,
-0.3877933919429779,
0.007613274268805981,
0.2442013919353485,
0.1290166676044464,
-0.32699811458587646,
-0.3784509301185608,
-0.15490123629570007,
0.2557602524757385,
-0.2647780478000641,
0.2346450537443161,
-0.07376956939697266,
0.016112996265292168,
-0.007019721437245607,
0.2107856124639511,
0.27913203835487366,
0.12954328954219818,
-0.6059620380401611,
0.08249776810407639,
-0.13497240841388702,
-0.28626230359077454,
-0.05341125279664993,
0.44777989387512207,
0.17822515964508057,
-0.13080307841300964,
0.23717039823532104,
-0.18250055611133575,
0.37249425053596497,
-0.37624526023864746,
-0.6373546123504639,
-0.22939781844615936,
-0.3036900460720062,
0.18646347522735596,
0.03955363482236862,
0.019968464970588684,
-0.21472427248954773,
0.0539727658033371,
-0.28310254216194153,
0.06355307996273041,
0.2759513258934021,
-0.24230076372623444,
0.17903898656368256,
-0.047858934849500656,
0.004929653834551573
] |
6,821,809 |
Corynebacterium parvum versus BCG adjuvant immunotherapy in human malignant melanoma.
|
Lipton A A, Harvey H A HA, Lawrence B B, Gottlieb R R, Kukrika M M, Dixon R R, Graham W W, Miller S S, Heckard R R, Schelzel D D, White D S DS
|
Cancer . Vol. 51, No. 1, 1983 Jan 01
|
One-hundred and sixteen patients with Stage I and Stage II malignant melanoma were randomized to treatment with either Bacillus Calmette-Guerin (BCG) (Tice) or subcutaneous Corynebacterium parvum (Burroughs-Wellcome). Life table analysis failed to reveal a difference between these two forms of treatment in 68 Stage I patients. The relapse rate was significantly reduced in Stage II patients treated with C. parvum.
|
https://pubmed.ncbi.nlm.nih.gov/6821809/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] |
6821809
|
[
0.5792303681373596,
0.2642866373062134,
-2.2464492321014404,
-1.305406928062439,
-1.0415023565292358,
0.1863539069890976,
0.5202895402908325,
0.23198722302913666,
-0.1180448904633522,
-0.7190303802490234,
-0.2525951862335205,
1.2189195156097412,
-1.610283613204956,
0.675774097442627,
-0.9764244556427002,
-0.8897050619125366,
-1.2855747938156128,
0.545505166053772,
-0.27551063895225525,
-0.655657947063446,
-0.27891823649406433,
-0.3566240072250366,
-1.518609642982483,
0.2699093520641327,
-0.6817612648010254,
-1.2386505603790283,
-0.39882728457450867,
0.5293883681297302,
-0.3513173758983612,
1.8594416379928589,
1.1154906749725342,
-0.21836668252944946,
0.5084561109542847,
0.8035877346992493,
-0.43316757678985596,
0.5769663453102112,
0.48429158329963684,
1.1798757314682007,
-0.5703672766685486,
-0.5216386914253235,
0.3937585949897766,
0.11768297851085663,
0.015198994427919388,
-0.3236454725265503,
-0.042987871915102005,
0.3897234797477722,
0.13996893167495728,
0.5687369108200073,
0.09156493097543716,
0.13936400413513184,
-0.683154284954071,
0.4430476129055023,
-0.06451403349637985,
0.41009578108787537,
1.0439229011535645,
1.2091652154922485,
0.14220887422561646,
0.7315270304679871,
1.723460078239441,
0.26420101523399353,
1.2876893281936646,
0.8963094353675842,
0.005717152263969183,
0.47828808426856995,
0.06112603843212128,
-0.7832939624786377,
-0.42473724484443665,
0.6230549216270447,
-1.226852297782898,
0.24373172223567963,
0.1874665766954422,
0.7107601761817932,
1.039426565170288,
-0.6177070140838623,
0.6032115817070007,
1.2618600130081177,
-0.49375292658805847,
0.7337357401847839,
0.3960830271244049,
0.18259745836257935,
0.03584841638803482,
0.1856098771095276,
0.6723204255104065,
0.33716055750846863,
-0.24603107571601868,
-1.2053539752960205,
-0.7669785022735596,
-0.6269674897193909,
0.052876610308885574,
-1.4845213890075684,
0.5040135979652405,
-0.9574258327484131,
-0.976063072681427,
0.14146316051483154,
-0.9009897112846375,
0.6952419281005859,
-0.8242204189300537,
0.19572679698467255,
-0.011493013240396976,
0.46581435203552246,
-0.802012026309967,
-0.0682971179485321,
0.1603052169084549,
-0.6246583461761475,
-0.4593030512332916,
-0.5205966830253601,
0.3128700852394104,
-0.9747732281684875,
0.08610138297080994,
-1.228568434715271,
1.4493048191070557,
-0.6781966686248779,
-0.3196869492530823,
-1.0237153768539429,
0.004905567038804293,
1.00028657913208,
0.8106929659843445,
-0.3584628701210022,
-0.7296270132064819,
0.0024457857944071293,
0.004372087772935629,
0.9787929058074951,
-0.8649951219558716,
0.6257646679878235,
-0.37652966380119324,
0.24400892853736877,
-0.28109636902809143,
0.47082722187042236,
-0.12527403235435486,
-0.14012761414051056,
-0.5535138249397278,
0.028098661452531815,
-0.2536817789077759,
-0.17216043174266815,
-0.6072385907173157,
-0.46422192454338074,
-0.9215999841690063,
1.585211992263794,
0.6108672022819519,
-0.4950888454914093,
0.20725275576114655,
0.4170190095901489,
0.019442737102508545,
-0.18816189467906952,
-0.5564871430397034,
-0.7124325633049011,
-0.21007654070854187,
0.7619149684906006,
-1.0258262157440186,
0.6791326403617859,
-0.42588555812835693,
-0.03351461514830589,
0.07577092945575714,
0.1305789053440094,
0.01889321394264698,
0.4323577582836151,
0.5142026543617249,
-0.5545822381973267,
0.09848198294639587,
-0.033726852387189865,
-0.7478653192520142,
-0.38018864393234253,
-0.12450814247131348,
-0.8594728708267212,
0.8238429427146912,
-0.6430298089981079,
-0.3693256676197052,
-0.375156432390213,
0.05024000257253647,
-0.29600268602371216,
-0.5608091950416565,
-0.2183436006307602,
0.3111952543258667,
-0.37992894649505615,
-0.13381856679916382,
-0.04961339384317398,
0.542999804019928,
0.3566129803657532,
0.11519475281238556,
-0.18128865957260132,
-0.11394546180963516,
-0.41790571808815,
-0.09734021127223969,
0.08587026596069336,
0.04389544948935509,
0.015871500596404076,
-0.06437985599040985,
0.1983509659767151,
-0.20934969186782837,
0.4666987359523773,
0.18952664732933044,
-0.24525569379329681,
-0.0044655464589595795,
0.5538783669471741,
0.7155066728591919,
-0.0864870548248291,
-0.5817902088165283,
0.2759975790977478,
0.6395105719566345,
0.7184218764305115,
0.30187007784843445,
0.34060099720954895,
0.24802984297275543,
0.5549467206001282,
-0.21893510222434998,
-0.46853378415107727,
0.36060574650764465,
-0.028300054371356964,
-0.1139650046825409,
0.45200636982917786,
-0.1452440470457077,
0.23616646230220795,
0.3086169958114624,
0.09438874572515488,
0.18288053572177887,
0.2697277069091797,
0.4475690424442291,
0.0960421934723854,
-0.10866379737854004,
-0.1935744434595108,
-0.056968897581100464,
-0.09034447371959686,
0.29570701718330383,
0.1031760573387146,
0.370360791683197,
0.5320327877998352,
-0.05600004643201828,
0.1213458850979805,
-0.2540341019630432,
-0.4865632653236389,
-0.45328742265701294,
-0.19942298531532288,
-0.12327804416418076,
0.3487943410873413,
0.3903665542602539,
0.09127335250377655,
-0.07448435574769974,
-0.24943426251411438,
0.12571710348129272,
0.20956575870513916,
0.05013709142804146,
-0.5666818022727966,
-0.7218535542488098,
-0.3517308831214905,
-0.287276953458786,
0.004267909564077854,
0.2943187952041626,
-0.45699405670166016,
-0.2913911044597626,
0.3151087164878845,
-0.004210731014609337,
0.3397694528102875,
0.0714588314294815,
0.2833090126514435,
-0.36896082758903503,
-0.5166788101196289
] |
6,821,866 |
Primary Ewing's sarcoma of the ribs. A report from the intergroup Ewing's sarcoma study.
|
Thomas P R PR, Foulkes M A MA, Gilula L A LA, Burgert E O EO, Evans R G RG, Kissane J J, Nesbit M E ME, Pritchard D J DJ, Tefft M M, Vietti T J TJ
|
Cancer . Vol. 51, No. 6, 1983 Mar 15
|
Thirty-six patients with primary Ewing's sarcoma of the ribs have been reviewed. Of these, 21 had clinically localized disease at diagnosis and were entered on protocol IESS 7299, eight had regional and seven metastatic disease at diagnosis and were entered on protocol 7450. The 21 with localized disease were treated with surgical excision or biopsy, followed by local radiotherapy (in all but one patient) and randomization to one of three chemotherapy regimens. Eleven patients (52%) remain disease-free for periods ranging from 18 to 64 months, respectively. Seven of eight patients who underwent complete surgical excision of the primary lesion remain disease-free, compared with four of 12 (excluding one patient who died disease-free) who remain disease-free after partial excision or biopsy. However, analysis of size of tumor at diagnosis reveals that smaller primary tumors have a better prognosis irrespective of extent of surgery. Protocol IESS 7450, consisted of radiotherapy to all areas of known disease and four drug chemotherapy. Four (50%) with regional disease but none with metastatic disease have remained alive and continuously disease-free. It is concluded that an aggressive approach to Ewing's sarcoma of the ribs is justified by the results, as even regional disease may be curable. The apparent prognostic advantage for those patients undergoing surgical excision may be explained by patient selection.
|
https://pubmed.ncbi.nlm.nih.gov/6821866/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] |
6821866
|
[
0.5759197473526001,
2.0539956092834473,
-1.1185559034347534,
0.07872370630502701,
0.10346297919750214,
-0.061529289931058884,
-0.9031400680541992,
-0.2878604233264923,
-0.7846956849098206,
0.16952423751354218,
-0.17200018465518951,
2.4157958030700684,
-1.1547389030456543,
-0.8062857389450073,
-0.28206318616867065,
-0.0526873879134655,
0.042233072221279144,
0.27692151069641113,
0.7059001326560974,
-1.2742451429367065,
0.162199005484581,
-0.14588432013988495,
-0.3206590712070465,
-0.1048898696899414,
0.4204399585723877,
-0.6478433012962341,
-0.18037550151348114,
0.4271271526813507,
-0.5131953358650208,
0.5922335982322693,
0.01882701925933361,
0.48834407329559326,
0.5683014392852783,
0.268290638923645,
0.3102295398712158,
-0.09684211015701294,
0.0915357694029808,
0.32800814509391785,
-0.8373064994812012,
-0.3487481474876404,
0.9298503398895264,
0.05483642593026161,
-0.5140905380249023,
-0.7292822003364563,
1.5335924625396729,
0.2884468138217926,
0.5121110677719116,
0.4367090165615082,
0.7076335549354553,
0.1930278241634369,
-0.8933343291282654,
1.3258118629455566,
-1.3915635347366333,
1.0097005367279053,
1.5103833675384521,
-0.21503275632858276,
0.5431010723114014,
0.43963199853897095,
0.5787011981010437,
0.6732335090637207,
1.0700820684432983,
0.3213817775249481,
-0.6997911334037781,
-0.4408714175224304,
-0.3376573622226715,
-1.3667365312576294,
-0.22915707528591156,
0.49545320868492126,
0.14435681700706482,
0.015209338627755642,
0.22497040033340454,
-0.09563364088535309,
0.15196791291236877,
-0.4436912536621094,
0.24669843912124634,
0.16773241758346558,
-0.7436739802360535,
0.32851502299308777,
0.36731308698654175,
-0.22055968642234802,
-0.8243765234947205,
-0.6801327466964722,
-0.32539069652557373,
0.32986465096473694,
-0.1903238296508789,
-0.43646037578582764,
-1.102210521697998,
-0.268545001745224,
0.5685485601425171,
-1.298073649406433,
0.3523924648761749,
-0.5318479537963867,
-0.2481517195701599,
0.5987008213996887,
-0.4194301664829254,
0.7054397463798523,
-0.2677386403083801,
-0.18294592201709747,
-1.1609976291656494,
-1.1707415580749512,
-0.776925802230835,
-0.055183619260787964,
-0.5426117181777954,
-0.7099921107292175,
-0.4674084782600403,
-0.20290607213974,
-0.049777086824178696,
-0.5307496190071106,
-0.7023380994796753,
-1.0211862325668335,
1.0464822053909302,
-0.6612597107887268,
0.21226269006729126,
-0.5660690665245056,
-0.6359670162200928,
-0.5514274835586548,
0.7161585688591003,
0.005739652086049318,
0.07566599547863007,
0.038431208580732346,
-0.1836918145418167,
0.19092649221420288,
-0.8157233595848083,
0.19597163796424866,
-0.3063376545906067,
-0.2929033935070038,
-0.1965171843767166,
0.8500845432281494,
-0.259790301322937,
-0.7481539249420166,
-0.8082807660102844,
0.20855367183685303,
0.024577433243393898,
-0.09177684783935547,
-0.14455311000347137,
-0.0081980861723423,
-0.17009343206882477,
1.8974369764328003,
-0.22786901891231537,
-0.5241047143936157,
0.8372107744216919,
0.4934996962547302,
-0.26067453622817993,
0.7330648303031921,
-1.5334796905517578,
-0.13669198751449585,
0.004018703941255808,
0.3468799293041229,
-0.546617329120636,
-0.5871325135231018,
0.5161658525466919,
0.1917954385280609,
-0.1152995228767395,
0.284091979265213,
0.27321282029151917,
0.7481427788734436,
0.11714249849319458,
0.14833304286003113,
-0.1457025408744812,
-0.22099241614341736,
-0.5389257073402405,
-0.2543427050113678,
0.5692054033279419,
-1.251693606376648,
0.6982737183570862,
-0.19025655090808868,
0.1421981006860733,
0.16268135607242584,
-0.055332034826278687,
0.22788898646831512,
0.13913896679878235,
0.09567490220069885,
0.3531661033630371,
0.25641781091690063,
-0.4622284770011902,
0.33045291900634766,
0.8744845390319824,
0.18404553830623627,
1.3854740858078003,
-0.5008808970451355,
-0.11946934461593628,
-0.07983114570379257,
0.2689218819141388,
-0.25975707173347473,
-0.33272606134414673,
0.6178281903266907,
-0.025981666520237923,
0.27346527576446533,
-0.3913378119468689,
0.2504415214061737,
0.11927013844251633,
-0.5258833169937134,
0.40637126564979553,
0.844264566898346,
0.6438277959823608,
0.36984696984291077,
-0.31800365447998047,
0.08148311823606491,
0.7929871678352356,
0.179076686501503,
-0.016419343650341034,
-0.4348265528678894,
-0.27811136841773987,
-0.020158950239419937,
-0.23619255423545837,
-0.07688792794942856,
0.5920447707176208,
0.22439181804656982,
-0.46141958236694336,
0.4526006877422333,
0.15651898086071014,
0.3252350687980652,
0.4571743905544281,
-0.272352397441864,
-0.02117764949798584,
0.35349801182746887,
0.3316279649734497,
-0.04076152294874191,
-0.8051458597183228,
-0.14513958990573883,
-0.14136652648448944,
-0.40454280376434326,
0.05415162071585655,
-0.1404096931219101,
0.2611163854598999,
-0.003873388050124049,
-0.12223391234874725,
0.0928867980837822,
0.05691796913743019,
-0.5595501065254211,
-0.11794852465391159,
0.1733773946762085,
0.09040793776512146,
-0.2529945373535156,
0.015124078840017319,
0.2956131398677826,
0.3112969994544983,
0.02600547857582569,
-0.2123761773109436,
0.41959238052368164,
0.058437950909137726,
-0.31142109632492065,
-0.21402865648269653,
-0.5888546705245972,
0.02663007378578186,
-0.02723436988890171,
0.09295825660228729,
-0.296024888753891,
0.6780802607536316,
0.2795974910259247,
-0.01327845361083746,
-0.0677480697631836,
0.4063042402267456,
-0.14117780327796936,
0.6281297206878662,
-0.34570664167404175
] |
6,821,904 |
Combined hemodynamic effects of dopamine and dobutamine in cardiogenic shock.
|
Richard C C, Ricome J L JL, Rimailho A A, Bottineau G G, Auzepy P P
|
Circulation . Vol. 67, No. 3, 1983 Mar
|
In eight mechanically ventilated patients in cardiogenic shock, we assessed the hemodynamic effects of an infusion of dopamine and dobutamine and evaluated its role in preventing the deleterious effects of administering each amine alone. Each patient received three infusions in a randomly assigned order: dopamine, 15 micrograms/kg/min; dobutamine, 15 micrograms/kg/min; and a combination of dopamine, 7.5 micrograms/kg/min, and dobutamine, 7.5 micrograms/kg/min. Stroke volume index increased similarly with the three infusions, but dopamine alone increased oxygen consumption (p less than 0.05 vs dobutamine alone and dopamine-dobutamine combined). The dopamine-dobutamine combination increased mean arterial pressure (p less than 0.05 vs dobutamine), maintained pulmonary capillary wedge pressure within normal limits (p less than vs dopamine), and prevented the worsening of hypoxemia induced by dopamine (p less than 0.05). The dopamine-dobutamine combination appears to be useful in the management of mechanically ventilated patients in cardiogenic shock.
|
https://pubmed.ncbi.nlm.nih.gov/6821904/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6821904
|
[
-0.7025293707847595,
0.23883457481861115,
-1.735385537147522,
-4.811048984527588,
2.06062912940979,
-0.44021040201187134,
2.6911680698394775,
0.08820752799510956,
0.28442618250846863,
-0.21595799922943115,
-0.8243577480316162,
2.2365972995758057,
-0.031562887132167816,
0.2773715853691101,
1.1076158285140991,
-1.3581472635269165,
-0.9760939478874207,
1.0767933130264282,
0.959495484828949,
-1.0432144403457642,
0.04051476716995239,
-1.7592535018920898,
-0.1861034333705902,
-0.4593369662761688,
-0.3444446325302124,
-0.0007206393056549132,
0.5361300706863403,
1.983627200126648,
1.0373728275299072,
1.034563660621643,
0.6648175716400146,
-0.4683593511581421,
0.7068612575531006,
0.1372966468334198,
-0.3314073085784912,
-0.1506076604127884,
1.8096190690994263,
0.8236050605773926,
-0.6010533571243286,
-0.33885952830314636,
-0.2890889048576355,
1.7386857271194458,
1.2937064170837402,
0.7171021699905396,
0.44062212109565735,
-0.06665986776351929,
0.5689193606376648,
0.5632168650627136,
0.4826814532279968,
0.9442461729049683,
-0.5532767176628113,
0.8692166209220886,
-0.596042275428772,
-0.27953413128852844,
1.7146048545837402,
-0.09974569827318192,
0.2707693576812744,
0.08030486106872559,
0.5320063233375549,
-0.08599931746721268,
-0.7986463308334351,
-0.1166544258594513,
0.8884420394897461,
0.2950717806816101,
-0.6730148196220398,
0.46295684576034546,
-0.4070377051830292,
0.46365922689437866,
-1.932668924331665,
0.8148930668830872,
-0.09197597950696945,
0.8024137616157532,
-1.0858705043792725,
0.46042144298553467,
0.987999677658081,
1.840137243270874,
-0.18373893201351166,
1.67534339427948,
0.20274204015731812,
0.38892799615859985,
-1.549544095993042,
-0.12336206436157227,
0.2757631838321686,
-0.36767953634262085,
-0.39921826124191284,
0.9174788594245911,
-0.6936768293380737,
-0.996955156326294,
0.4303145110607147,
-0.08937521278858185,
-0.001310800900682807,
-0.6450833082199097,
-1.576398253440857,
0.882319450378418,
-0.5914859175682068,
0.13984613120555878,
0.4982360601425171,
1.1046652793884277,
-0.8916976451873779,
-0.1771211326122284,
0.6596260070800781,
0.2524507939815521,
-0.20829059183597565,
0.04852664843201637,
-0.47033998370170593,
-0.1420341581106186,
0.3017627000808716,
-1.0546610355377197,
0.07376281917095184,
-0.42348170280456543,
0.30037298798561096,
-0.3357090950012207,
-0.26424843072891235,
-0.8177917003631592,
0.5723801255226135,
0.2555773854255676,
0.04241554066538811,
-0.3368835747241974,
-0.07104983925819397,
-0.4226025342941284,
0.5803710222244263,
0.09549923986196518,
-0.15900039672851562,
1.0785611867904663,
-0.24709342420101166,
-0.2318619042634964,
0.33332324028015137,
-0.087473563849926,
0.3503132462501526,
-0.7394610047340393,
0.10408491641283035,
0.6791630387306213,
0.3339434862136841,
-0.6782497763633728,
-0.7872368693351746,
-0.38959529995918274,
0.7344674468040466,
0.44528794288635254,
0.1715095043182373,
-0.6107255220413208,
-0.23270811140537262,
1.2792348861694336,
-0.29313185811042786,
-0.08179692924022675,
-0.9742391705513,
0.1949891448020935,
-0.026668120175600052,
0.4667661488056183,
-0.45126476883888245,
0.23012305796146393,
-0.9711816906929016,
0.931847870349884,
-0.044331517070531845,
-0.3106546998023987,
0.05587710067629814,
-0.24169954657554626,
0.6567319631576538,
0.07346785068511963,
0.3952406346797943,
-0.33138754963874817,
0.17114965617656708,
-0.07031486183404922,
-0.2184152603149414,
-0.21126466989517212,
0.5246597528457642,
-0.23566533625125885,
0.21996872127056122,
-0.2153967022895813,
0.0690087154507637,
-0.4247962534427643,
-0.6960782408714294,
0.438619464635849,
-0.0909615010023117,
0.16504214704036713,
0.032223232090473175,
-0.01526278629899025,
0.5596314668655396,
-0.025259720161557198,
0.12129619717597961,
-0.19406360387802124,
-0.26840299367904663,
-0.010609920136630535,
0.17859786748886108,
-0.5195158123970032,
0.2300238162279129,
-0.7211111783981323,
0.3281773328781128,
-0.897327721118927,
0.05902832746505737,
0.33596593141555786,
-0.05608043819665909,
0.12118616700172424,
-0.5325360298156738,
0.19022686779499054,
0.12208253890275955,
-0.10758184641599655,
-0.29911574721336365,
-0.05886797606945038,
0.002696935785934329,
-0.42620572447776794,
0.12739044427871704,
0.7018430233001709,
-0.1311575472354889,
0.73585444688797,
-0.39397215843200684,
-0.1077200397849083,
0.11328501999378204,
0.45617911219596863,
-0.40576598048210144,
0.5910460352897644,
0.0024133194237947464,
0.33673158288002014,
-0.36260220408439636,
0.27087000012397766,
0.14164108037948608,
-0.1259884238243103,
0.12340423464775085,
0.04888015612959862,
-0.20433494448661804,
0.16652755439281464,
-0.11553556472063065,
-0.5669586062431335,
-0.187260702252388,
-0.04554068669676781,
0.23554474115371704,
-0.261605441570282,
0.22010736167430878,
0.46568381786346436,
-0.12397929280996323,
-0.39371007680892944,
-0.4639871120452881,
0.04967155680060387,
0.08672235161066055,
-0.271001398563385,
0.2781131863594055,
0.20723411440849304,
-0.22590859234333038,
0.06000719964504242,
0.1816791296005249,
0.1267498880624771,
-0.2754961848258972,
-0.6326320767402649,
-0.03284769132733345,
-0.5864433646202087,
0.5314933061599731,
-0.0532028004527092,
0.21912598609924316,
-0.282164603471756,
0.004167569801211357,
-0.19004595279693604,
0.32766661047935486,
0.17045387625694275,
-0.006630660034716129,
0.09130451828241348,
-0.4762096405029297,
-0.15817035734653473
] |
6,822,042 |
Femoral artery flow and pain during lumbar aortography: comparison of ionic and non-ionic contrast media.
|
Padayachee T S TS, Reidy J F JF, King D H DH, Reeves M M, Gosling R G RG
|
Clinical radiology . Vol. 34, No. 1, 1983 Jan
|
A method is described for non-invasively measuring the increase in lower limb blood flow during transfemoral lumbar aortography. Flow measurements were made using a continuous wave Doppler-shift ultrasound transducer placed over the contralateral femoral artery. The effect of the non-ionic contrast medium B15000 (Iopamidol), conventional contrast medium (Urografin 370) and Urografin 370 plus Lignocaine were compared in a double-blind trial. All three produced an increase in flow which reached a peak between 12 and 45 s after injection. The peak flow following Iopamidol was significantly lower than that from both Urografin 370 alone and with addition of Lignocaine. There was a difference of lesser degree between Urografin 370 plus Lignocaine and Urografin 370 alone; however, this was not statistically significant. The subjective assessments of pain and patient 'discomfort' paralleled these objective flow measurements.
|
https://pubmed.ncbi.nlm.nih.gov/6822042/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6822042
|
[
0.21246658265590668,
0.4043334424495697,
-2.9094467163085938,
-3.1735827922821045,
0.8760932087898254,
1.2414418458938599,
2.0249545574188232,
-0.6327666640281677,
-0.37868961691856384,
0.3873675763607025,
-0.056299660354852676,
0.22055040299892426,
-0.16380861401557922,
0.28180259466171265,
-0.010825051926076412,
2.7784838676452637,
-1.8179911375045776,
-0.530236542224884,
0.6116010546684265,
-0.9084948301315308,
1.2667018175125122,
0.21915346384048462,
0.2374366670846939,
0.19607092440128326,
1.0116029977798462,
0.09412745386362076,
0.9408354759216309,
-0.29881036281585693,
-0.2359389215707779,
0.7185062170028687,
0.9853625893592834,
-1.1727665662765503,
0.302852064371109,
1.518555760383606,
0.16132842004299164,
-0.37860193848609924,
1.1456929445266724,
0.043725743889808655,
-0.32342666387557983,
0.11802636086940765,
0.42700880765914917,
0.9450519680976868,
0.9076342582702637,
-0.26955094933509827,
1.5172642469406128,
-0.10358403623104095,
0.107270747423172,
0.845935046672821,
0.540314257144928,
-0.24758759140968323,
-0.32312989234924316,
-0.64579838514328,
-1.1355922222137451,
-0.007954094558954239,
-0.6015297770500183,
0.8304492831230164,
-0.09004011750221252,
0.9367483854293823,
0.2821095585823059,
0.04599323123693466,
-0.10584156215190887,
-0.08538557589054108,
0.13136781752109528,
0.8584893345832825,
-0.16550283133983612,
-0.21100671589374542,
-0.45558056235313416,
-0.47157007455825806,
-0.4743767976760864,
-0.16214975714683533,
-0.40445658564567566,
0.5495211482048035,
0.11191979050636292,
0.8327057957649231,
0.9005515575408936,
1.1634644269943237,
-1.580962896347046,
0.8236934542655945,
0.21923065185546875,
1.315565586090088,
-0.954452633857727,
-0.6083247065544128,
-0.5420643091201782,
0.25377655029296875,
0.3916654884815216,
-0.016152845695614815,
-0.6614589691162109,
-0.506639301776886,
-0.2227819710969925,
-0.47654828429222107,
0.7326560020446777,
0.2507769763469696,
-0.9273379445075989,
0.34653788805007935,
-0.18337157368659973,
-0.8167628049850464,
-0.02963683381676674,
-0.8648821115493774,
-0.7363717555999756,
-0.07154092192649841,
-0.1198340356349945,
-0.5716528296470642,
-0.3232194781303406,
0.4852656126022339,
0.13781538605690002,
-0.6341049671173096,
-0.3290272057056427,
-0.5338163375854492,
-0.5080016851425171,
-0.3200245499610901,
0.3044179379940033,
-0.34424957633018494,
-0.7977476119995117,
-0.8661444783210754,
-0.15903660655021667,
1.2641644477844238,
0.4096828103065491,
-0.3161880373954773,
0.24716204404830933,
-0.9484534859657288,
0.08360675722360611,
0.7674500346183777,
0.08588553220033646,
0.605065107345581,
-0.6226330995559692,
0.2603372633457184,
0.2637614607810974,
-0.027052342891693115,
-0.5727060437202454,
-0.3759639263153076,
-0.5554353594779968,
0.9423181414604187,
0.05756581947207451,
-0.3447413444519043,
-0.41456326842308044,
-0.7907479405403137,
0.31941235065460205,
0.5298904776573181,
-0.13777974247932434,
-0.07753373682498932,
-0.5671912431716919,
0.7291527390480042,
-0.1511794924736023,
-0.7642238736152649,
-0.6015781760215759,
-0.4071643352508545,
-0.32085490226745605,
0.650122880935669,
-0.9679495096206665,
0.4041999280452728,
-0.48824724555015564,
-0.039129871875047684,
0.31129106879234314,
0.019944218918681145,
0.11697237938642502,
0.024927079677581787,
0.21114949882030487,
0.27978208661079407,
0.23907572031021118,
-0.2993350923061371,
0.3787371814250946,
0.3479519486427307,
-0.17968595027923584,
0.0014420528896152973,
0.1740722358226776,
-0.8351479768753052,
-0.20853528380393982,
-0.6706852316856384,
0.5095553994178772,
-0.6858209371566772,
-0.6603208184242249,
0.21844740211963654,
0.30219241976737976,
0.07217064499855042,
-0.2627145051956177,
0.6507958769798279,
-0.0014629490906372666,
0.7237929701805115,
0.2891804277896881,
-0.5779152512550354,
0.5109685063362122,
0.40148380398750305,
-0.026250764727592468,
-0.18103018403053284,
-0.356637567281723,
-0.5334199070930481,
-0.06857213377952576,
-0.2567097246646881,
-0.027671948075294495,
0.4114857017993927,
0.184500053524971,
0.12879687547683716,
-0.05147499218583107,
-0.14557914435863495,
0.32360437512397766,
0.29189303517341614,
-0.43948185443878174,
0.24304354190826416,
0.2847733497619629,
-0.10063918679952621,
0.0451207309961319,
0.4747372269630432,
0.24384741485118866,
0.4325528144836426,
0.19345952570438385,
0.11304060369729996,
-0.1707977056503296,
0.020862720906734467,
-0.04704788699746132,
0.30068525671958923,
0.5321350693702698,
-0.09153826534748077,
-0.2853263318538666,
-0.1227644756436348,
0.22217333316802979,
0.33195966482162476,
0.07268046587705612,
0.23555031418800354,
-0.25045710802078247,
0.0017379072960466146,
0.08825515955686569,
-0.02904665656387806,
-0.006433715578168631,
-0.10650841146707535,
0.13983532786369324,
-0.39108535647392273,
-0.5366483926773071,
0.44321179389953613,
0.1427658051252365,
-0.2224595695734024,
-0.6085938811302185,
-0.4430397152900696,
0.09829525649547577,
0.06896932423114777,
-0.7336054444313049,
-0.24095311760902405,
-0.07532214373350143,
0.20578986406326294,
0.3411180078983307,
0.022850854322314262,
-0.03601246327161789,
-0.2632477283477783,
-0.24586045742034912,
-0.724331259727478,
0.4090289771556854,
0.23996374011039734,
0.1525876522064209,
-0.23204173147678375,
0.2318582832813263,
-0.5163936614990234,
-0.004923555534332991,
0.07123440504074097,
-0.08407534658908844,
0.16410192847251892,
-0.15990546345710754,
-0.14224889874458313
] |
6,822,051 |
Factors influencing the regional deposition of inhaled particles in man.
|
Chamberlain M J MJ, Morgan W K WK, Vinitski S S
|
Clinical science (London, England : 1979) . Vol. 64, No. 1, 1983 Jan
|
1. Although ventilation in normal human lungs has been shown to decrease from apex to base, comparable observations are lacking in regard to particle deposition. 2. We compared regional ventilation and particle deposition in normal subjects by using radioactive xenon and a radioactive aerosol while sitting, lying, and while breathing at an increased rate. Both smokers and non-smokers were studied. 3. Particle deposition and ventilation were closely related, and the greater the ventilation the greater the deposition of particles, a situation which prevailed irrespective of position and breathing rate. While supine, the apex to base gradient for both ventilation and particle deposition decreased but did not entirely disappear. At higher respiratory rates, central deposition of particles, especially in smokers, increased. 4. We concluded that there are regional differences in the deposition of particles and that such differences are closely related to regional ventilation.
|
https://pubmed.ncbi.nlm.nih.gov/6822051/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6822051
|
[
-0.197538360953331,
2.433605670928955,
-0.8143376708030701,
-1.5667697191238403,
-0.1918202042579651,
-0.5309464931488037,
0.24003639817237854,
-1.9458445310592651,
-2.1832973957061768,
-0.5439558029174805,
0.6493270397186279,
-0.0963568314909935,
0.28649595379829407,
0.1678626537322998,
-1.3968679904937744,
1.203729271888733,
-1.7421295642852783,
1.3827838897705078,
1.2760822772979736,
-1.2543188333511353,
1.312453031539917,
-0.9352151155471802,
-0.41980960965156555,
0.9050023555755615,
0.47482630610466003,
0.2889140844345093,
-0.09948607534170151,
-0.7672183513641357,
0.7053887248039246,
-0.3956250846385956,
1.086761236190796,
0.05724440515041351,
-1.1308965682983398,
-0.8933011889457703,
-0.7624725103378296,
-0.654938817024231,
-0.09275636076927185,
0.3521767854690552,
0.6964635252952576,
-0.6208156943321228,
-1.4596126079559326,
1.2170236110687256,
0.8458694815635681,
-1.1778604984283447,
0.7707376480102539,
0.44384056329727173,
0.01777620241045952,
-0.2287379503250122,
-0.8199466466903687,
-2.0014281272888184,
-0.9575799703598022,
-0.5699164867401123,
0.7361862659454346,
0.8419051766395569,
1.7713267803192139,
-0.9773203730583191,
0.45496252179145813,
-1.0200121402740479,
0.22594207525253296,
-1.102827787399292,
1.0004997253417969,
0.6320798397064209,
0.3918575942516327,
-0.7310962080955505,
0.20274436473846436,
-0.44120141863822937,
-0.3392448425292969,
0.06357145309448242,
-1.369850993156433,
0.6688534021377563,
-0.41439759731292725,
0.08583487570285797,
0.9260368943214417,
0.7807456851005554,
0.8319233655929565,
-0.1388315111398697,
0.04937594383955002,
-0.8539424538612366,
-0.10676480084657669,
0.3549315929412842,
-1.2580220699310303,
0.4449785053730011,
-1.408004641532898,
-0.37497949600219727,
-0.20431368052959442,
0.06648265570402145,
-0.8116437792778015,
-0.19624440371990204,
0.598632276058197,
-0.6862059831619263,
-0.5637529492378235,
-0.19157394766807556,
-2.0901336669921875,
1.3436975479125977,
0.8950903415679932,
0.5749624371528625,
-0.5203402042388916,
0.7809619903564453,
-0.4102950692176819,
0.006046383175998926,
1.9802238941192627,
0.9171687364578247,
0.5134341716766357,
0.7516420483589172,
-0.27215176820755005,
-0.4421028792858124,
0.23330378532409668,
-1.1624414920806885,
-0.7557862401008606,
0.1195652112364769,
0.7404648065567017,
0.0809321179986,
0.27627184987068176,
-0.5469089150428772,
1.5864490270614624,
0.05346065014600754,
0.4995667338371277,
0.6457940936088562,
-0.23856830596923828,
-1.2818822860717773,
-0.2202925980091095,
-0.2663044333457947,
0.11483847349882126,
1.1717511415481567,
-0.29607856273651123,
-0.16098614037036896,
-0.5395184755325317,
0.4218081533908844,
-0.2510235011577606,
-0.8635092377662659,
0.7264572381973267,
0.8123161792755127,
0.14259687066078186,
-1.3526828289031982,
-0.7339965105056763,
-0.2066722810268402,
0.4824015200138092,
0.880730152130127,
0.9835235476493835,
-0.2709718644618988,
-0.0683501809835434,
0.44375553727149963,
0.7683210968971252,
-0.042389754205942154,
-0.17575602233409882,
0.0012465802719816566,
0.0842861533164978,
-0.4159362018108368,
-0.5735390186309814,
0.37911704182624817,
-0.5851675868034363,
0.6696748733520508,
0.17060460150241852,
0.3826923072338104,
-0.10858293622732162,
0.9608539938926697,
1.0417635440826416,
1.0848442316055298,
-0.7864036560058594,
-0.09514550119638443,
0.5890485644340515,
0.5290341377258301,
-0.8495133519172668,
-0.1597871035337448,
0.7676848769187927,
-0.36116623878479004,
0.4243687093257904,
-0.11936413496732712,
-0.30684372782707214,
-0.08121959865093231,
-0.25625523924827576,
-0.42816004157066345,
0.05894029885530472,
0.18966080248355865,
-0.21085093915462494,
0.13389264047145844,
0.1705322563648224,
-0.08467495441436768,
0.3254733979701996,
-0.758972704410553,
0.6860383152961731,
0.3850955665111542,
0.49821582436561584,
0.2896770238876343,
-0.0830347090959549,
0.07725146412849426,
0.5862760543823242,
-0.617064356803894,
0.35669195652008057,
-0.20164959132671356,
-1.1456328630447388,
0.060212209820747375,
0.01417104434221983,
0.2867986261844635,
0.7164643406867981,
0.34743574261665344,
-0.35927876830101013,
0.04955893009901047,
-0.08738204091787338,
0.047490332275629044,
-0.04368175193667412,
-0.29478880763053894,
0.2962336540222168,
0.12103572487831116,
-0.4896530210971832,
-0.0888431966304779,
-0.03332708403468132,
0.3104463219642639,
-0.47999703884124756,
0.44949811697006226,
0.2735012471675873,
0.4709378182888031,
0.1297050267457962,
0.2111169397830963,
-0.10595999658107758,
0.35445553064346313,
0.3883722722530365,
0.10837078839540482,
0.1479654759168625,
-0.4112280607223511,
0.2745664715766907,
0.008338415995240211,
-0.42733830213546753,
-0.18577004969120026,
-0.1161016970872879,
0.3149469792842865,
0.13433417677879333,
-0.271638423204422,
0.07944945991039276,
-0.4955151677131653,
-0.7998971343040466,
-0.6248320937156677,
0.2523949146270752,
0.08414548635482788,
-0.45204707980155945,
-0.4683614671230316,
-0.3520299792289734,
-0.04839794337749481,
0.21122905611991882,
-0.2359546571969986,
0.5238187909126282,
-0.41621193289756775,
-0.5025529265403748,
0.0692221000790596,
0.4874248504638672,
-0.4345359206199646,
0.632331371307373,
-0.12823225557804108,
-0.17856158316135406,
-0.48621612787246704,
0.23374904692173004,
-0.3159032166004181,
0.03665943816304207,
0.519835352897644,
-0.11647685617208481,
-0.32513701915740967
] |
6,822,050 |
Pain and fatigue after concentric and eccentric muscle contractions.
|
Newham D J DJ, Mills K R KR, Quigley B M BM, Edwards R H RH
|
Clinical science (London, England : 1979) . Vol. 64, No. 1, 1983 Jan
|
1. Normal subjects performed a step test in which the quadriceps of one leg contracted concentrically while the contralateral muscle contracted eccentrically. 2. Maximal voluntary force and the force: frequency relationship were altered bilaterally as a result of the exercise, the changes being greater in the muscle which had contracted eccentrically. Recovery occurred over 24 h. 3. Electromyographic studies using three sites on each muscle showed an increase in electrical activation during the exercise only in the muscle which was contracting eccentrically. Recovery followed a time course similar to that of the contractile properties. 4. Pain and tenderness developed only in the muscle which had contracted eccentrically. Pain was first noted approximately 8 h after exercise and was maximal at approximately 48 h after exercise, at which time force generation and electrical activation had returned to pre-exercise values. 5. Eccentric contractions cause more profound changes in some aspects of muscle function than concentric contractions. These changes cannot be explained in simple metabolic terms, and it is suggested that they are the result of mechanical trauma caused by the high tension generated in relatively few active fibres during eccentric contractions.
|
https://pubmed.ncbi.nlm.nih.gov/6822050/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6822050
|
[
-3.093069314956665,
1.4585875272750854,
-1.0494277477264404,
-2.04095196723938,
0.547693133354187,
0.7183064222335815,
-0.3077015280723572,
-1.0263206958770752,
0.2836407423019409,
0.7881792187690735,
-0.21070696413516998,
1.3877204656600952,
-0.34925544261932373,
-0.24758239090442657,
-0.9432271122932434,
0.45348691940307617,
-0.8380075693130493,
-1.0780202150344849,
-0.22694848477840424,
-0.27296045422554016,
-1.316559076309204,
0.5948444604873657,
-1.1801750659942627,
-0.44093459844589233,
1.9329664707183838,
0.41504430770874023,
0.37776023149490356,
-0.6071863770484924,
0.44538143277168274,
-0.14206993579864502,
-1.118067741394043,
-0.7572640776634216,
0.9939668774604797,
0.471353143453598,
-0.4834042191505432,
-0.03352156654000282,
0.14971120655536652,
-0.5118124485015869,
-0.61745685338974,
-0.9054209589958191,
0.47988617420196533,
1.5587718486785889,
-0.376163125038147,
0.31366440653800964,
1.1778050661087036,
0.8042164444923401,
0.017891624942421913,
-0.639695942401886,
1.268607497215271,
-0.4544695019721985,
0.6358463168144226,
0.7536798715591431,
-0.6620373725891113,
-0.19927218556404114,
0.1338188350200653,
0.29543235898017883,
0.6855336427688599,
-0.588181734085083,
-0.9427832961082458,
0.629347562789917,
0.4610900580883026,
0.6618566513061523,
-0.42642033100128174,
0.28300586342811584,
0.4914912283420563,
-1.5595074892044067,
1.3840808868408203,
0.34514257311820984,
-1.035282850265503,
0.581847608089447,
0.9622067809104919,
0.3758080303668976,
-0.8516173958778381,
0.2759196162223816,
0.07708325982093811,
0.4294789433479309,
-0.4421575963497162,
0.5994948148727417,
1.2769393920898438,
0.03590099513530731,
0.20437978208065033,
-0.8836700320243835,
-0.5346236228942871,
0.6301390528678894,
0.037991963326931,
0.8873181939125061,
-0.38994431495666504,
-0.5082690119743347,
0.25483766198158264,
-1.016066551208496,
-0.8272301554679871,
-0.615520179271698,
-0.5600603222846985,
-0.17933756113052368,
-0.10947199910879135,
0.753937840461731,
0.2251470386981964,
-0.6857886910438538,
-0.09556318074464798,
-0.45441046357154846,
0.31149348616600037,
0.3205397129058838,
0.5285301804542542,
-0.7492591142654419,
-0.8718968033790588,
-0.3447500169277191,
-0.3011144995689392,
-0.5631111860275269,
-0.5410112142562866,
0.3532531261444092,
0.4650523066520691,
-0.1703217327594757,
-0.32008668780326843,
0.10573991388082504,
0.3654821217060089,
0.15944628417491913,
-0.30853113532066345,
0.08364883065223694,
-0.176998570561409,
-0.44212567806243896,
-0.07982850074768066,
0.7915884852409363,
-0.36290013790130615,
0.46914517879486084,
-0.44370952248573303,
-0.5883079171180725,
0.22758087515830994,
0.5627397298812866,
-0.4718836843967438,
-0.7099237442016602,
0.10752040892839432,
0.38318610191345215,
1.0173659324645996,
-0.07145342230796814,
-0.48098039627075195,
0.10318130999803543,
-0.6580941081047058,
0.13236357271671295,
-0.2959112226963043,
0.22630950808525085,
0.029633156955242157,
0.5758163332939148,
-0.22273430228233337,
0.40783870220184326,
0.19533948600292206,
-0.11279985308647156,
-0.3696058690547943,
0.5382874608039856,
0.013209815137088299,
0.6754536032676697,
0.32477524876594543,
-0.026636233553290367,
0.5427342653274536,
-0.36765673756599426,
-0.1396557092666626,
-0.5415942668914795,
-0.08369957655668259,
-0.22737202048301697,
-0.020098047330975533,
0.03802107647061348,
0.7666646838188171,
0.09004940092563629,
-0.397504985332489,
0.4513055086135864,
0.04070671275258064,
-0.1900484263896942,
-0.21568946540355682,
-0.05494881793856621,
0.9302313923835754,
-0.09494280815124512,
0.20504476130008698,
-0.5935156345367432,
0.16897980868816376,
1.0031673908233643,
-0.09482661634683609,
0.6725519895553589,
0.32855620980262756,
0.04826069995760918,
0.9151856899261475,
-0.21647092700004578,
0.20366060733795166,
-0.4527038335800171,
0.26918402314186096,
0.6464759707450867,
-0.464257150888443,
-0.01901029422879219,
0.10031575709581375,
-0.4858981668949127,
0.02161014825105667,
0.058999937027692795,
0.15524552762508392,
0.1891629546880722,
-0.2317771464586258,
-0.3149551451206207,
-0.23035281896591187,
0.6086974740028381,
-0.5124973058700562,
-0.6469641923904419,
0.4842761754989624,
-0.1797821968793869,
-0.08128451555967331,
-0.07723080366849899,
-0.36304232478141785,
0.5445725321769714,
0.0821698009967804,
0.16657361388206482,
-0.6930716037750244,
-0.0009351536282338202,
-0.4491095542907715,
-0.035737164318561554,
-0.08792494982481003,
0.1245584562420845,
-0.31334710121154785,
0.3004623055458069,
-0.04156647250056267,
0.6036520600318909,
-0.11368108540773392,
-0.2504521906375885,
-0.4037235975265503,
0.13575413823127747,
0.01622263714671135,
-0.31630411744117737,
0.15382933616638184,
-0.6274308562278748,
-0.25823134183883667,
-0.3160003125667572,
0.14947770535945892,
0.20466233789920807,
-0.10163049399852753,
0.20716029405593872,
-0.48380088806152344,
-0.3039916455745697,
0.030641162768006325,
-0.24093538522720337,
0.4909609854221344,
0.0734858587384224,
-0.287151038646698,
0.1667006015777588,
0.3617367446422577,
0.09761347621679306,
-0.05258007347583771,
-0.3655327260494232,
0.1009344831109047,
0.1528884917497635,
0.47576355934143066,
-0.27928003668785095,
0.23860876262187958,
0.5782161355018616,
0.39657387137413025,
-0.041023362427949905,
0.24521178007125854,
-0.08076082915067673,
-0.25028398633003235,
0.12067822366952896,
0.2554541528224945,
-0.3216312527656555
] |
6,822,085 |
Nutritional status in intensive care patients: evaluation in 84 unselected patients.
|
Boles J M JM, Garre M A MA, Youinou P Y PY, Mialon P P, Menez J F JF, Jouquan J J, Miossec P J PJ, Pennec Y Y, Le Menn G G
|
Critical care medicine . Vol. 11, No. 2, 1983 Feb
|
A prospective nutritional evaluation of 84 unselected patients admitted to a multidisciplinary ICU was performed using anthropometric measurements, creatinine height index (CHI), and serum protein assays. All values tested were significantly lower than those of 40 healthy controls. A matrix of correlation coefficients showed many similarities among the variables studied. Fatal outcome and poor prognosis indices, such as sepsis and renal failure, were analyzed separately. Anthropometric measurements and CHI were not different in the separate groups. Albumin (Alb) and transferrin (Tr) were not different in patients with or without sepsis. Retinol binding prealbumin was significantly higher in patients with renal failure. Thyroxin-binding prealbumin (TBPA) was significantly lower in all the groups. We emphasize the interest of this rapid turnover protein in evaluating nutritional status. We suggest: (1) a systematic nutritional assessment, and (2) an aggressive nutritional support in the ICU patient.
|
https://pubmed.ncbi.nlm.nih.gov/6822085/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6822085
|
[
1.3228461742401123,
1.732230305671692,
-3.6059112548828125,
-2.787655830383301,
1.687121033668518,
0.10461219400167465,
-0.27657896280288696,
-0.4575496315956116,
-1.1382495164871216,
-0.8903468251228333,
-0.046023525297641754,
1.5876723527908325,
-1.1132628917694092,
0.13904015719890594,
-1.6004531383514404,
0.5457925200462341,
-0.7997944355010986,
0.5089607834815979,
1.0435830354690552,
-1.948301911354065,
-0.11122102290391922,
0.32722651958465576,
0.006653902120888233,
0.7149181962013245,
0.6328811049461365,
0.058605071157217026,
-0.3658445179462433,
1.0676991939544678,
-0.5341694355010986,
0.5586667060852051,
0.8651783466339111,
-0.7707207798957825,
-0.014325722120702267,
0.11622099578380585,
0.7580788135528564,
-0.3471250832080841,
0.8561009168624878,
0.24455322325229645,
-1.1765488386154175,
0.07924472540616989,
1.3663557767868042,
0.1238505095243454,
-0.6344562768936157,
1.0745465755462646,
1.253176212310791,
-0.04771668091416359,
0.2628480792045593,
0.5393238663673401,
0.010012641549110413,
0.034552231431007385,
-0.9433518648147583,
0.8984846472740173,
-1.274978518486023,
-0.5147904753684998,
1.3059253692626953,
0.3759741485118866,
1.2861194610595703,
0.23211440443992615,
1.2925918102264404,
0.1375845968723297,
1.0176243782043457,
-0.013887086883187294,
-0.3322821259498596,
1.2591569423675537,
-1.1423001289367676,
-0.4146817922592163,
0.07328791171312332,
0.614091157913208,
-0.9190990924835205,
0.5619238018989563,
-0.6935524344444275,
0.1302812099456787,
0.28805240988731384,
-0.15084895491600037,
0.7045408487319946,
0.4341066777706146,
-1.0641318559646606,
1.1931846141815186,
-0.7458168268203735,
1.346086025238037,
-0.16155657172203064,
-0.8681392073631287,
-0.5379000306129456,
0.21992850303649902,
0.5371853113174438,
0.5380690097808838,
-1.519287347793579,
-0.4797026813030243,
0.7800776958465576,
-1.2164216041564941,
-0.30815455317497253,
-1.1332615613937378,
-0.9582249522209167,
0.7748369574546814,
-0.4069361090660095,
-0.08530514687299728,
-0.2589986324310303,
0.6006385087966919,
-0.5118908286094666,
-0.5390586256980896,
0.09985872358083725,
-0.3371606469154358,
-0.29997265338897705,
0.37179943919181824,
0.03645109385251999,
-0.4222690165042877,
-0.09260041266679764,
-0.0457555390894413,
-0.24483737349510193,
-0.11701787263154984,
0.3225809335708618,
0.04725054278969765,
-0.1086331233382225,
-0.9793450832366943,
-0.20444270968437195,
0.31285667419433594,
-0.17996138334274292,
-0.2908985912799835,
0.2874636948108673,
-0.3290592432022095,
-0.5926918983459473,
0.415566086769104,
-0.17498579621315002,
0.5918744802474976,
-0.6535784006118774,
0.12260107696056366,
0.13893622159957886,
-0.1567496955394745,
-0.10738814622163773,
0.050427500158548355,
-1.4133517742156982,
-0.006006353534758091,
-0.03176174312829971,
0.018638111650943756,
-0.09776614606380463,
0.6767803430557251,
-0.09901238977909088,
0.9558194875717163,
0.2674308121204376,
-0.03857983648777008,
-0.3977101445198059,
0.11322678625583649,
-0.24936626851558685,
0.5967189073562622,
-0.9907069802284241,
0.10572350770235062,
-0.12856733798980713,
0.059922702610492706,
-0.15854793787002563,
0.29716598987579346,
-0.1813098043203354,
0.2887706458568573,
0.3966105878353119,
-0.0413680262863636,
-0.26100268959999084,
0.34781816601753235,
0.3321993947029114,
0.0794604942202568,
-0.20702871680259705,
0.6912288069725037,
0.1750241369009018,
-0.36314457654953003,
-0.15495862066745758,
-0.8828178644180298,
-0.10450078547000885,
-0.30821719765663147,
-0.16243989765644073,
0.005741574335843325,
0.3768879771232605,
0.15139545500278473,
-1.0184098482131958,
0.3834247291088104,
-0.14102157950401306,
0.6137728095054626,
-0.15382084250450134,
0.21828541159629822,
0.055032528936862946,
0.4433131814002991,
0.6338642835617065,
-0.06241573393344879,
0.033889252692461014,
-0.36173585057258606,
0.12260901182889938,
-0.2321743220090866,
0.11059866845607758,
0.2073480486869812,
-0.23171797394752502,
-0.7489877939224243,
0.12645098567008972,
0.16463811695575714,
-0.21001960337162018,
0.12886783480644226,
-0.19546589255332947,
-0.21458786725997925,
0.45294541120529175,
0.012197851203382015,
-0.06773127615451813,
-0.3240869343280792,
0.15073564648628235,
-0.3711530864238739,
-0.24791043996810913,
0.12731872498989105,
0.031634144484996796,
0.22357586026191711,
-0.3690313994884491,
-0.14691348373889923,
-0.16438302397727966,
-0.2882532477378845,
-0.22047989070415497,
0.45047086477279663,
0.1203257143497467,
0.4073861539363861,
0.09910599887371063,
0.17157655954360962,
0.5249451398849487,
0.32442936301231384,
0.1953662931919098,
-0.06342418491840363,
-0.427489697933197,
-0.01914834976196289,
0.17744897305965424,
-0.15083879232406616,
-0.14963068068027496,
0.14864212274551392,
-0.25465935468673706,
0.14561061561107635,
0.07067770510911942,
-0.12566033005714417,
0.3072976768016815,
0.6001042127609253,
-0.2521169185638428,
-0.11144601553678513,
-0.28235867619514465,
0.12269144505262375,
0.2788136303424835,
-0.12780418992042542,
-0.10859380662441254,
0.029644552618265152,
-0.3158785104751587,
0.28058359026908875,
0.21460691094398499,
-0.2829129993915558,
0.10128753632307053,
-0.2642526924610138,
0.2905660569667816,
-0.14108902215957642,
0.21778108179569244,
-0.13174673914909363,
-0.1464269906282425,
-0.02471923828125,
0.08311013877391815,
-0.1398850828409195,
0.15590327978134155,
0.21103136241436005,
0.12057879567146301,
-0.023969819769263268
] |
6,822,108 |
The additive antianginal action of oral isosorbide dinitrate in patients receiving propranolol. Magnitude and duration of effect.
|
Bassan M M MM, Weiler-Ravell D D
|
Chest . Vol. 83, No. 2, 1983 Feb
|
Ten men with stable angina not completely relieved by full doses of propranolol (mean, 218 mg daily) were given double-blind, on alternate mornings, a placebo or an oral dose (5 to 30 mg) of isosorbide dinitrate (ISDN) previously titrated to lower sitting systolic blood pressure by 20 mm Hg. Patients had been trained in a protocol which precipitated angina after three to six minutes of bicycle exercise. On test days, with propranolol continued, bicycle exercise was performed until the appearance of angina before ISDN or placebo administration, and hourly thereafter for eight hours. Mean exercise duration was greater one hour after ISDN than after placebo by 182 sec (423 +/- 39 vs 241 +/- 13, p less than 0.001), and a difference of 63 sec was still present at six hours (p less than 0.002). At one hour, ISDN lowered resting systolic blood pressure by 26 mm Hg (from 114 +/- 5 mm Hg to 88 +/- 4 mm Hg; p less than .001) without appreciably changing heart rate. We conclude that ISDN is a very effective and reasonably long-acting antianginal supplement to propranolol.
|
https://pubmed.ncbi.nlm.nih.gov/6822108/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6822108
|
[
-0.7298474907875061,
0.7808675169944763,
-1.7144660949707031,
-2.0489370822906494,
1.3573561906814575,
1.3341059684753418,
1.8448976278305054,
0.7141204476356506,
-0.10518764704465866,
-0.22825327515602112,
-0.8349013924598694,
-0.4081629812717438,
-0.2763727605342865,
-0.47863325476646423,
-0.5247329473495483,
-0.32392558455467224,
-0.45949408411979675,
-0.2618933320045471,
0.5879800319671631,
-1.5984035730361938,
0.5590797066688538,
-0.38550516963005066,
-0.8481701612472534,
-0.09492451697587967,
-0.3030563294887543,
-0.446068674325943,
0.7551311254501343,
0.5283743739128113,
0.27046817541122437,
0.6741448044776917,
0.3251107633113861,
-0.9286574721336365,
0.943837583065033,
0.3696880638599396,
0.4847854971885681,
0.5039979815483093,
0.48407524824142456,
-1.169610857963562,
-0.1988697648048401,
-0.16813381016254425,
0.18581779301166534,
0.2546785771846771,
0.2612781524658203,
-0.8204467296600342,
1.3459887504577637,
0.3601601719856262,
1.0783635377883911,
0.11421649158000946,
0.41063210368156433,
-0.4315698742866516,
-0.746796727180481,
-0.30636170506477356,
-0.14151808619499207,
0.40907058119773865,
1.0162445306777954,
0.5881743431091309,
0.6855344772338867,
-0.34235572814941406,
0.5424028635025024,
-0.7177479863166809,
0.024850044399499893,
-0.6424878239631653,
0.24782663583755493,
-0.19220933318138123,
0.14454138278961182,
-0.367634117603302,
0.6640082597732544,
0.38017719984054565,
-0.8686199188232422,
0.3027772605419159,
-0.17850849032402039,
-0.23996411263942719,
0.7145477533340454,
-0.5054159164428711,
1.1253026723861694,
0.7164372205734253,
-0.7400206327438354,
0.8522182703018188,
0.012091579847037792,
0.05004589259624481,
-0.6989384293556213,
0.25196361541748047,
0.47034406661987305,
0.03386661782860756,
0.5073164105415344,
0.3794390559196472,
-0.5538768768310547,
-0.15097035467624664,
0.6065633296966553,
-0.7473989725112915,
0.12333086133003235,
-0.6313916444778442,
-0.9550685882568359,
0.4067133367061615,
-0.26163697242736816,
0.13113082945346832,
0.15386758744716644,
-0.678274393081665,
0.022612465545535088,
0.0769381895661354,
0.26023074984550476,
0.06970522552728653,
0.12282145023345947,
0.45306339859962463,
-0.04443623870611191,
-0.32598721981048584,
-0.12521478533744812,
-0.8411941528320312,
-0.9004329442977905,
-0.6577497720718384,
-0.524860680103302,
-0.1394040733575821,
-0.22720183432102203,
-0.22258375585079193,
0.5404586791992188,
0.22326667606830597,
0.08081411570310593,
0.17982956767082214,
0.00045894680079072714,
-0.2025022953748703,
-0.6584622859954834,
0.82474285364151,
-0.048649862408638,
0.1809888482093811,
0.4207635819911957,
0.10913022607564926,
0.6123341917991638,
0.11855306476354599,
0.5173372030258179,
-0.37936994433403015,
-0.5677842497825623,
0.5110803842544556,
-0.14916078746318817,
-0.35164543986320496,
-0.8342020511627197,
-0.43040281534194946,
-0.3317888379096985,
0.6207327246665955,
0.1527571976184845,
0.06988820433616638,
-0.024775998666882515,
0.30242040753364563,
-0.7383687496185303,
-0.19234737753868103,
-0.9049028754234314,
0.05536133423447609,
-0.7731853723526001,
0.4475734233856201,
0.05602573603391647,
0.2180621176958084,
-0.2464396208524704,
0.2740243971347809,
-0.45927128195762634,
-0.44849035143852234,
-0.1873033046722412,
-0.21658620238304138,
-0.15403026342391968,
0.17222268879413605,
-0.160605326294899,
-0.11199068278074265,
0.37489748001098633,
-0.44097569584846497,
0.08458810299634933,
-0.03263859823346138,
0.4942188858985901,
0.5884416103363037,
-0.14141373336315155,
-0.04332525655627251,
0.011013824492692947,
-0.06416121125221252,
-0.9149819612503052,
0.40759095549583435,
0.18368637561798096,
0.22243113815784454,
-0.09742283076047897,
0.29540354013442993,
0.5947259068489075,
0.8364165425300598,
0.40325284004211426,
0.3517289459705353,
-0.3545362651348114,
-0.0744670033454895,
-0.09372284263372421,
0.08947592228651047,
0.19556477665901184,
-0.5165348649024963,
0.14205123484134674,
-0.036534301936626434,
0.1468052864074707,
0.35094204545021057,
0.09700019657611847,
-0.1482176035642624,
-0.004102066624909639,
0.4130227863788605,
0.24890224635601044,
-0.3677089512348175,
-0.3343494236469269,
0.5043470859527588,
0.3409489095211029,
0.07107231020927429,
-0.07316504418849945,
0.4667889475822449,
-0.26256489753723145,
0.6292829513549805,
0.013461818918585777,
0.008908437564969063,
-0.21390755474567413,
0.27623850107192993,
-0.2627870440483093,
-0.20866984128952026,
0.5450484156608582,
0.17652951180934906,
-0.046682991087436676,
0.24646103382110596,
0.1449190080165863,
-0.16515398025512695,
0.06741182506084442,
-0.0714658796787262,
-0.26996707916259766,
0.44630593061447144,
-0.06612832099199295,
-0.45707160234451294,
-0.02532639540731907,
-0.16900093853473663,
-0.005654550157487392,
-0.483331561088562,
0.15532498061656952,
0.5805332660675049,
-0.2337494194507599,
-0.2288389503955841,
-0.13405664265155792,
0.021751469001173973,
0.008935445919632912,
-0.10164788365364075,
0.18544167280197144,
-0.21956656873226166,
-0.3592132031917572,
0.08583445847034454,
0.06906887143850327,
-0.3204488158226013,
-0.03292382135987282,
-0.7933359742164612,
-0.2780532240867615,
-0.22224871814250946,
0.2645739018917084,
-0.08067500591278076,
-0.16877703368663788,
0.35398393869400024,
0.1278800368309021,
-0.2508503794670105,
0.4964682161808014,
-0.04382763430476189,
-0.24864117801189423,
0.38032066822052,
-0.10778607428073883,
-0.03799208253622055
] |
6,822,143 |
The use of clonidine monotherapy in adolescent hypertension.
|
Falkner B B, Onesti G G, Lowenthal D T DT, Affrime M B MB
|
Chest . Vol. 83, No. 2 Suppl, 1983 Feb
|
The effect of a centrally acting agent (clonidine) vs a diuretic as a single agent was studied in a group of hypertensive adolescents. Following placebo therapy, adolescents with blood pressure greater than 95th percentile were randomized to clonidine 0.1 mg or hydrochlorothiazide 25 mg, each given twice daily. Following 12 weeks' active treatment, those who had not achieved blood pressure goals proceeded to clonidine 0.2 mg or hydrochlorothiazide 50 mg twice daily. Blood pressure and clinical assessment was performed at two-week intervals. Cardiovascular response to mental stress and pre-post stress catecholamines were obtained prior to active therapy and during therapy. Clonidine therapy significantly lowered systolic and diastolic pressure and heart rate (p less than .01). Hydrochlorothiazide significantly lowered systolic pressure only. Mental stress testing resulted in a lower diastolic pressure and heart rate response (p less than .01), with lower norepinephrine in the clonidine-treated group. The diuretic group had higher plasma norepinephrine and no significant reduction in stress response. Hypertensive juveniles may be more sensitive to central control of blood pressure and more resistant to diuretics.
|
https://pubmed.ncbi.nlm.nih.gov/6822143/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6822143
|
[
-0.768879234790802,
-0.5998215079307556,
-2.162177801132202,
-2.9142069816589355,
0.9418343901634216,
0.19633924961090088,
1.874194860458374,
1.32075035572052,
-0.09968968480825424,
0.15890461206436157,
0.2475285530090332,
1.4516925811767578,
0.1693694293498993,
-0.40597450733184814,
-0.6672546863555908,
-0.23688670992851257,
-0.30884087085723877,
0.42767783999443054,
0.5965677499771118,
-2.089409828186035,
1.7590340375900269,
-0.9506936073303223,
0.4831390976905823,
-0.6904589533805847,
0.24647758901119232,
-0.6083473563194275,
-0.11412256956100464,
1.3575336933135986,
0.7883433103561401,
0.8897883296012878,
0.8274244666099548,
-0.15145263075828552,
0.7945877909660339,
-0.6016082763671875,
-0.4320752024650574,
-0.9011229276657104,
0.3767584562301636,
-0.5851249098777771,
0.005038772709667683,
-0.04151443392038345,
1.3597993850708008,
1.2486445903778076,
-0.34949225187301636,
-0.8044277429580688,
1.1721251010894775,
1.1732330322265625,
0.9975306391716003,
-0.3565589189529419,
1.6097468137741089,
0.3315950334072113,
-0.16730082035064697,
1.1210451126098633,
-0.806638240814209,
-0.2235003411769867,
1.61798095703125,
0.5042619705200195,
0.6014277338981628,
0.4367664158344269,
0.511937141418457,
-0.560653805732727,
0.29742059111595154,
0.6826001405715942,
0.14211973547935486,
1.1069356203079224,
-1.1794644594192505,
-0.2855873107910156,
1.9175478219985962,
-0.24519553780555725,
-1.0872893333435059,
0.47607916593551636,
-0.42693933844566345,
0.5466165542602539,
0.40998536348342896,
0.916954517364502,
1.671891689300537,
-0.07436586916446686,
-0.7929419875144958,
2.135770797729492,
0.413983017206192,
0.09789394587278366,
-1.821104884147644,
0.5458431839942932,
-0.5320413708686829,
0.6975419521331787,
0.36160391569137573,
-0.2685563564300537,
-0.49495992064476013,
-1.0246654748916626,
1.1498386859893799,
-0.8867672085762024,
-0.27251535654067993,
-0.5442580580711365,
-0.9001715779304504,
0.9237191081047058,
0.5548509955406189,
1.1576443910598755,
-0.6113414764404297,
-0.11412937939167023,
-0.08167649060487747,
0.7898581624031067,
0.8879494071006775,
-0.4773018956184387,
-0.7383663058280945,
0.6102059483528137,
-0.9239398241043091,
-0.6804826855659485,
-0.1389971226453781,
-0.836770236492157,
-0.6184433102607727,
-0.6198506355285645,
0.11089654266834259,
0.07838106900453568,
-0.06097346544265747,
-0.78877192735672,
1.1698153018951416,
0.7813594341278076,
-0.07551705837249756,
-0.8129196166992188,
-0.6800013184547424,
-0.17608502507209778,
0.34580686688423157,
1.8518500328063965,
-0.345464289188385,
0.40458521246910095,
-0.8477451205253601,
0.37267768383026123,
0.1505506932735443,
-1.000028371810913,
-0.029524866491556168,
-0.5697331428527832,
-0.29909899830818176,
0.8012534379959106,
-0.5079074501991272,
-0.2758253812789917,
-1.2273484468460083,
-0.39895808696746826,
0.15410780906677246,
0.728967547416687,
-0.34380704164505005,
-0.5491308569908142,
-0.24551144242286682,
0.6228967308998108,
-0.8386678695678711,
-0.3959873616695404,
-0.6621837019920349,
-0.22727720439434052,
-0.0415150485932827,
0.40285417437553406,
-0.5123133063316345,
-0.04562215879559517,
-0.6818758249282837,
0.12355741113424301,
-0.08433938026428223,
-0.1599305272102356,
-0.29509299993515015,
-0.6327438950538635,
-0.2253912389278412,
-0.1517675369977951,
0.7008645534515381,
-0.755180299282074,
-0.2873654365539551,
-0.46632954478263855,
-0.18574656546115875,
-0.2570153474807739,
0.6846271753311157,
-0.34644490480422974,
-0.7957101464271545,
-0.18472930788993835,
0.30268290638923645,
-0.5226187109947205,
-0.9461246728897095,
0.6270933151245117,
-0.10484158992767334,
0.4011737108230591,
-0.5632546544075012,
0.14807961881160736,
-0.00023965290165506303,
0.3170580565929413,
-0.000050923194066854194,
-0.3863379955291748,
-0.22129584848880768,
0.4883500039577484,
-0.06160885840654373,
-0.604661762714386,
-0.009121643379330635,
-0.41339120268821716,
-0.06192759796977043,
-0.4038733243942261,
-0.11004603654146194,
0.2252599596977234,
0.14346478879451752,
0.28667113184928894,
-0.10386582463979721,
-0.5241339206695557,
0.5226519107818604,
0.04092559218406677,
0.02536468580365181,
-0.1271848827600479,
0.005827765911817551,
-0.4285455346107483,
0.4749293625354767,
0.6108535528182983,
0.0235297791659832,
0.32409435510635376,
0.228242889046669,
-0.29622912406921387,
-0.04227003827691078,
0.2462877482175827,
-0.8209651708602905,
0.46993425488471985,
-0.3454917073249817,
-0.11296875774860382,
0.2141103446483612,
0.11238422244787216,
0.39027583599090576,
0.01678902469575405,
0.45792725682258606,
-0.28371164202690125,
-0.24206404387950897,
0.12524090707302094,
0.04508179426193237,
-0.433504581451416,
0.1732727587223053,
0.04639936983585358,
-0.1819668710231781,
0.2570641338825226,
0.3040221035480499,
-0.0005096271634101868,
-0.3740379810333252,
-0.06297164410352707,
-0.3186025321483612,
-0.5791100263595581,
0.00018378232198301703,
-0.7257391810417175,
0.08654267340898514,
-0.0056944359093904495,
-0.05094515532255173,
-0.1778973788022995,
-0.03234733268618584,
-0.26225727796554565,
-0.07316604256629944,
-0.3220331370830536,
-0.26923003792762756,
0.015577363781630993,
0.5340691208839417,
-0.012295463122427464,
-0.24019382894039154,
-0.05222479999065399,
-0.05435491353273392,
-0.09042457491159439,
-0.11712982505559921,
0.011487561278045177,
0.0033899997361004353,
0.3945060074329376,
0.03944123908877373,
0.01585470139980316
] |
6,822,175 |
Protective colostomy in low anterior resection of the rectum using the EEA stapling instrument. A randomized study.
|
Graffner H H, Fredlund P P, Olsson S A SA, Oscarson J J, Petersson B G BG
|
Diseases of the colon and rectum . Vol. 26, No. 2, 1983 Feb
|
The need for protective transverse colostomy in low anterior resection using the EEA stapler was tested in a randomized series of 50 patients, half of whom received peroperative protective colostomy. Gastrografin enema on the tenth postoperative day showed a leakage frequency of 30 per cent in both groups. Clinical leakage was noted in 4 per cent (one patient) in the colostomy group and 12 per cent (three patients) in the noncolostomy group. Protective colostomy was followed by stenosis in nine instances, compared with only two in the noncolostomy group (2 alpha = 0.05). Routine protective colostomy should not be used in low anterior resection when the EEA stapling instrument is used. The occasional clinical leakage, which may appear in the postoperative period, can be revealed by close observation and successfully treated by an emergency colostomy. The majority of patients with anterior resection of the rectum, therefore, can be spared the inconvenience and cost of temporary colostomy.
|
https://pubmed.ncbi.nlm.nih.gov/6822175/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6822175
|
[
-1.1196315288543701,
2.2868759632110596,
-2.265561819076538,
-1.8648830652236938,
0.616136372089386,
0.3384341895580292,
0.4842087924480438,
0.6922438740730286,
-1.8162057399749756,
0.9019364714622498,
0.8521113395690918,
0.7831442952156067,
-0.06922443211078644,
-0.39519497752189636,
0.5196210741996765,
0.2543801963329315,
-0.27922919392585754,
0.4180965721607208,
-0.9120309948921204,
-1.4607934951782227,
0.6701388359069824,
-0.8277532458305359,
-0.7404381036758423,
-0.704176127910614,
0.4694957733154297,
-0.5947679877281189,
1.1729576587677002,
0.6193602681159973,
0.036874495446681976,
0.7195788621902466,
-0.3762218952178955,
-0.6403688192367554,
-0.003296339651569724,
0.398419052362442,
-0.5799499154090881,
-0.6207613348960876,
-0.15487100183963776,
0.18322300910949707,
-0.2437964230775833,
-0.24825285375118256,
0.6544041037559509,
-0.6775161027908325,
-0.8611550331115723,
-0.4789528548717499,
1.2874536514282227,
-0.5385538339614868,
1.4109002351760864,
-0.4176136553287506,
-0.2002197802066803,
-0.20213501155376434,
-1.3965157270431519,
0.07224076241254807,
-0.8960517048835754,
-0.4642088711261749,
1.1974695920944214,
0.24660396575927734,
-0.09255538880825043,
0.06165744736790657,
0.7610360383987427,
-0.3843899369239807,
1.1975682973861694,
-0.0688258707523346,
-0.0596952959895134,
-0.1505766659975052,
-1.0733226537704468,
-0.8988212943077087,
-0.33685141801834106,
0.6014903783798218,
-0.3162575662136078,
0.4997934401035309,
0.8041934967041016,
1.2623218297958374,
0.7689026594161987,
0.7797173261642456,
0.7466647028923035,
0.682233452796936,
0.44272083044052124,
0.07617194205522537,
0.6642821431159973,
0.056641243398189545,
-0.10976747423410416,
0.2715538442134857,
-0.3180939555168152,
-0.1745714694261551,
-0.12671838700771332,
0.6819654107093811,
-0.7155231237411499,
-0.5412566065788269,
1.3625545501708984,
-1.1943976879119873,
0.2765128016471863,
-0.09806899726390839,
-1.1449499130249023,
0.06811804324388504,
-0.261993408203125,
0.483959823846817,
-0.3561549782752991,
-0.40608757734298706,
-0.5347927212715149,
-0.22024068236351013,
-0.35559603571891785,
-0.3415658473968506,
-0.3782912790775299,
-0.2741340398788452,
-0.7803276777267456,
0.15693223476409912,
0.10900270938873291,
-0.1292337328195572,
-0.4306465983390808,
0.0838451236486435,
0.2628032863140106,
-1.1407098770141602,
-0.3502640724182129,
-0.28256338834762573,
-0.5756134986877441,
0.618768036365509,
0.22200608253479004,
-0.18580634891986847,
0.46280404925346375,
-0.678279459476471,
0.3385334014892578,
0.7907130122184753,
-0.05612844228744507,
1.0916569232940674,
0.06080165505409241,
-0.1713002473115921,
-0.3945445418357849,
1.144700050354004,
0.5438401699066162,
1.322393774986267,
-0.5727567076683044,
0.6056691408157349,
-0.5215635895729065,
-0.6502323746681213,
-1.5983041524887085,
0.2899215817451477,
0.3194701373577118,
-0.10084730386734009,
-0.4271576404571533,
0.16984106600284576,
0.14579249918460846,
-0.272749125957489,
0.0002995134855154902,
-0.3046972453594208,
-1.3673142194747925,
-0.004991334863007069,
-0.4322998523712158,
0.8360101580619812,
-1.1647355556488037,
-0.42642584443092346,
0.09923558682203293,
-0.35544565320014954,
0.8564918637275696,
0.2523689568042755,
0.1340796798467636,
0.5615553259849548,
0.19818322360515594,
0.1542142927646637,
-0.36400938034057617,
0.1201624870300293,
0.465480238199234,
-0.6467269659042358,
0.7171177268028259,
-0.870297908782959,
0.3870815634727478,
-0.11499559134244919,
-0.2353328913450241,
-0.0480511412024498,
0.7669692039489746,
0.4616296887397766,
-0.38610491156578064,
-0.17080296576023102,
0.924953043460846,
0.8853940963745117,
-0.4463844299316406,
-0.3084203600883484,
0.539044976234436,
-0.18155863881111145,
0.56441730260849,
-0.3014334738254547,
0.009056159295141697,
-0.29486221075057983,
-0.00600737938657403,
-0.08539843559265137,
-0.14696800708770752,
0.08575465530157089,
0.2890801727771759,
-0.7287490963935852,
-0.7091538310050964,
0.3312304615974426,
0.08412325382232666,
0.592681348323822,
-0.01581553928554058,
0.17609290778636932,
0.3336234986782074,
-0.07512163370847702,
-0.47147300839424133,
0.024856215342879295,
0.48869919776916504,
-0.6975765228271484,
0.6497119069099426,
0.13387933373451233,
-0.2088213413953781,
-0.017847251147031784,
0.31648558378219604,
-0.5094459652900696,
0.06054128333926201,
0.19743669033050537,
-0.7305923104286194,
0.2595440745353699,
-0.26730257272720337,
0.15087001025676727,
0.8226524591445923,
-0.133547842502594,
-0.42870762944221497,
-0.13990190625190735,
0.4806608557701111,
-0.5949569940567017,
-0.8745583295822144,
0.0905693992972374,
0.3443816602230072,
-0.3714698851108551,
-0.3131231963634491,
-0.08087204396724701,
0.03730388358235359,
-0.14548400044441223,
0.29833441972732544,
0.1879013627767563,
-0.3873293697834015,
-0.16214333474636078,
0.23247531056404114,
-0.19503924250602722,
-0.26428455114364624,
-0.08092375844717026,
0.0914754793047905,
0.31275758147239685,
0.028335390612483025,
-0.3836173117160797,
0.001357235130853951,
0.6746786236763,
0.20719705522060394,
-0.6335793733596802,
-0.3635569214820862,
0.06345672905445099,
0.7381330728530884,
0.07972344011068344,
0.4062507152557373,
0.16967608034610748,
0.19868434965610504,
-0.3116181492805481,
-0.042530518025159836,
-0.07397326081991196,
0.5480824708938599,
-0.2437698096036911,
0.04611024260520935,
-0.1263253390789032
] |
6,822,321 |
Colonic inhibition of pancreatic and biliary secretion.
|
Owyang C C, Green L L, Rader D D
|
Gastroenterology . Vol. 84, No. 3, 1983 Mar
|
The purpose of this study was to determine whether or not nutrients in the colon influence pancreatic and biliary secretion in humans. In six healthy subjects, similar caloric loads (117 cals) of oleic acid, essential amino acids, and glucose in isomolar (280 mosmol/L), similar pH (7.4) solutions were infused into the right colon at 10 ml/min through a colonic tube passed by mouth. A background of submaximal pancreatic and biliary secretion was maintained by continuous intravenous infusion of the octapeptide of cholecystokinin. Biliary and pancreatic secretions were quantitated using the gastroduodenal intubation perfusion technique. Among the three nutrients tested, only oleic acid in the colon decreased pancreatic enzymes and bicarbonate outputs. The mean trypsin output decreased from 26.3 +/- 2.6 kU/h to 12.3 +/- 1.9 kU/h (46% +/- 6% of control), while the lipase output decreased from 62 +/- 6.6 kU/h to 36 +/- 5.6 kU/h (58% +/- 6% of control). Similarly, the output of bicarbonate in the duodenal aspirate decreased from 31 +/- 7.2 mEq/h to 16.3 +/- 3.1 mEq/h (61% +/- 5% of control). Intracolonic perfusion of essential amino acids or glucose had no effect on pancreatic enzymes and bicarbonate secretion. In contrast, all three nutrients in the colon inhibited biliary secretion. The mean output of bilirubin decreased from 56 +/- 6 mg/h to 19 +/- 2 mg/h (35% +/- 5% of control) during intracolonic perfusion of oleic acid. Essential amino acids lowered the output of bilirubin from 54 +/- 12 mg/h to 31 +/- 8.6 mg/h (65% +/- 6% of control), whereas glucose lowered it from 53 +/- 12 mg/h to 22 +/- 4 mg/h (45% +/- 5% of control). This differing response of pancreatic and biliary output to intracolonic perfusion of nutrients suggests differential sensitivity of the pancreas and gallbladder to these inhibitory influences. In malabsorption states, unabsorbed nutrients in the colon may inhibit pancreatic and biliary secretion, further contributing to the loss of nutrients from the gastrointestinal tract.
|
https://pubmed.ncbi.nlm.nih.gov/6822321/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, U.S. Gov't, P.H.S."
] |
6822321
|
[
1.0524425506591797,
0.6225577592849731,
-3.2456741333007812,
-2.932554006576538,
0.8087992668151855,
0.2456357479095459,
0.598411500453949,
-0.718079686164856,
-0.9438929557800293,
0.017302505671977997,
0.03890154883265495,
0.6598706841468811,
-0.39762619137763977,
0.6551717519760132,
-0.13772466778755188,
-1.1312429904937744,
-1.128714919090271,
-0.3496977686882019,
0.7440249919891357,
-0.5237613916397095,
1.5917198657989502,
-0.250349760055542,
-0.6050924062728882,
0.6517631411552429,
0.1351480334997177,
-0.7655969858169556,
0.6455766558647156,
1.1071664094924927,
-0.04029880464076996,
0.42168518900871277,
0.5149316787719727,
0.31166017055511475,
-0.8797587752342224,
0.1556462198495865,
-0.23383113741874695,
0.030122214928269386,
1.3013510704040527,
-0.09096474200487137,
-0.14378587901592255,
-0.26972824335098267,
0.499799907207489,
0.590489387512207,
0.7451266646385193,
-0.10931643098592758,
0.8684920072555542,
-0.270557701587677,
0.30846625566482544,
-0.24079833924770355,
0.22476355731487274,
0.2873658835887909,
-0.12643615901470184,
0.8034268617630005,
-0.9342451095581055,
-0.4619968831539154,
0.2656339704990387,
0.6066381931304932,
-0.270807147026062,
-0.15776567161083221,
0.5658138990402222,
-0.9116619825363159,
0.06443513184785843,
-0.23453842103481293,
-0.7374496459960938,
-0.16204619407653809,
-0.19044984877109528,
-0.8153212070465088,
0.5872543454170227,
-0.09996068477630615,
-0.679288923740387,
1.2271392345428467,
-0.6514872908592224,
0.4813407063484192,
-0.10812068730592728,
0.06781141459941864,
0.6776660680770874,
0.5706287026405334,
0.20114679634571075,
1.3969805240631104,
0.291586309671402,
0.8263711333274841,
-0.6256964802742004,
0.32278284430503845,
-0.11085877567529678,
0.04002179950475693,
0.5859531164169312,
0.7636635303497314,
-0.5413296222686768,
-0.0594157949090004,
0.5480274558067322,
-0.8539414405822754,
0.6419501304626465,
-0.8287526369094849,
-1.3040642738342285,
0.3608056902885437,
-0.1901339441537857,
0.2996336817741394,
0.03212985023856163,
0.10798300802707672,
-0.2664003372192383,
0.11987221986055374,
-0.23171739280223846,
-0.029242929071187973,
-0.3187149167060852,
0.2951430380344391,
0.01116697397083044,
-0.08033312857151031,
-0.4652118384838104,
-0.2709827423095703,
-0.664088249206543,
-0.725033164024353,
0.4043501019477844,
-0.622515857219696,
-0.2587888836860657,
-0.6305952668190002,
-0.0052758632227778435,
0.5996671319007874,
-0.19262883067131042,
-0.04587315768003464,
0.26173338294029236,
-0.7036113739013672,
-0.04632602259516716,
0.3842743933200836,
-0.660336434841156,
0.5151724815368652,
0.31270843744277954,
0.09691140055656433,
0.3953738808631897,
-0.49062103033065796,
0.2570766806602478,
-0.21144899725914001,
0.00508479680866003,
0.5170470476150513,
0.3154718577861786,
-0.2939026653766632,
-0.5869218111038208,
0.12925171852111816,
-0.013681602664291859,
0.24577361345291138,
0.46439093351364136,
0.7057431936264038,
0.06563667953014374,
0.2645832896232605,
-0.670922577381134,
-0.450900137424469,
-0.872423529624939,
-0.014330512844026089,
-0.5108686089515686,
0.3144160509109497,
-0.6737895011901855,
0.20583176612854004,
0.3261122703552246,
0.009413152001798153,
0.8629645705223083,
-0.0241361353546381,
-0.17871926724910736,
-0.17732949554920197,
0.4204230010509491,
-0.255068838596344,
0.10140544176101685,
-0.029833858832716942,
-0.49916040897369385,
0.26287543773651123,
-0.389186292886734,
-0.19556014239788055,
0.6209336519241333,
-0.2887856066226959,
0.0011391754960641265,
-0.22788730263710022,
-0.09835725277662277,
-0.19872893393039703,
-0.37245121598243713,
-0.118686243891716,
-0.35841986536979675,
0.20789438486099243,
0.1785793900489807,
0.17123299837112427,
0.029227420687675476,
0.20869582891464233,
0.30520638823509216,
0.18474842607975006,
0.09934507310390472,
-0.046727504581213,
0.030771814286708832,
-0.05888025090098381,
-0.1491023600101471,
-0.10701017081737518,
0.2613542675971985,
-0.22537356615066528,
-0.10922668129205704,
0.29377058148384094,
0.039191149175167084,
0.36789029836654663,
-0.1932065486907959,
0.05444471165537834,
0.2020849585533142,
0.007095624227076769,
-0.21446651220321655,
0.07356959581375122,
0.34329700469970703,
-0.02669268473982811,
0.2513282001018524,
0.38940566778182983,
-0.1827596127986908,
0.11550165712833405,
0.09109511971473694,
0.06625300645828247,
0.03913958743214607,
0.28487110137939453,
0.040897760540246964,
0.32824522256851196,
0.30085670948028564,
-0.1260882169008255,
0.0575476698577404,
-0.035976242274045944,
0.028191670775413513,
0.08462218940258026,
0.12984322011470795,
0.35165199637413025,
-0.13397885859012604,
0.12231479585170746,
-0.0777682438492775,
0.07590987533330917,
-0.21636588871479034,
-0.3737352788448334,
-0.28787803649902344,
-0.04098619148135185,
-0.12580464780330658,
-0.24675267934799194,
-0.21655423939228058,
0.09006615728139877,
-0.20986096560955048,
0.08949118852615356,
-0.11721309274435043,
-0.1089363619685173,
0.012335821986198425,
0.26809215545654297,
-0.013322948478162289,
-0.2288181334733963,
-0.08706596493721008,
0.1451362669467926,
-0.15849891304969788,
-0.554364800453186,
0.006047399248927832,
0.4286786615848541,
0.12889288365840912,
-0.19285443425178528,
0.13260075449943542,
0.014114540070295334,
0.07681325823068619,
-0.4465756118297577,
0.40228432416915894,
0.2918209135532379,
0.1278102993965149,
0.06899625062942505,
-0.07396027445793152,
-0.1579110026359558
] |
6,822,483 |
Recognition and treatment of depression in a family medicine practice.
|
Zung W W WW, Magill M M, Moore J T JT, George D T DT
|
The Journal of clinical psychiatry . Vol. 44, No. 1, 1983 Jan
|
To test the hypothesis that depression is significantly underdiagnosed in general medical settings, the Zung Self-Rating Depression Scale was administered to 1,086 family medicine outpatients seen during a 12-month period before their initial medical examination. The effects of such screening on clinical recognition and treatment of depression were examined. Of the 1,086 patients, 143 (13.2%) were symptomatically depressed. These patients were randomized into two groups: 102 were identified as clinically depressed to their physician, and the remaining 41 were not (control group). Physicians diagnosed depression in 15% of the control group and in 68% of the identified group. At 4-week follow-up, 64% of the identified patients who were treated with maprotiline (16 of 25) showed improvement; only 28% of the identified patients who were electively not treated improved. Improvement occurred in only 18% of the control group. It appears that the diagnosis of depression is not ordinarily made in family medicine outpatient settings and that self-rating depression scales are useful diagnostic aids, whose regular use is indicated by the high prevalence of depression in general medical populations.
|
https://pubmed.ncbi.nlm.nih.gov/6822483/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6822483
|
[
-1.0171715021133423,
2.1985840797424316,
-0.9464759826660156,
0.5262616276741028,
0.24496006965637207,
1.381208062171936,
0.9827169179916382,
-0.6667371988296509,
-0.24462157487869263,
-0.062255918979644775,
0.24563898146152496,
2.219212532043457,
-0.6018206477165222,
0.6273728609085083,
-1.2955800294876099,
0.05802405998110771,
0.07195068150758743,
-0.474191814661026,
0.8185679912567139,
-1.8086838722229004,
-0.9453834891319275,
-0.30844220519065857,
-0.21790507435798645,
-0.7563454508781433,
0.09300887584686279,
-0.7342942357063293,
-0.5068582892417908,
2.5700631141662598,
-0.5661319494247437,
0.6940046548843384,
0.7690755128860474,
-0.2246595025062561,
-0.08522122353315353,
0.08732946217060089,
1.0048654079437256,
-0.7760885953903198,
-0.32397276163101196,
0.23401327431201935,
-1.0842838287353516,
0.3328218162059784,
-0.07617277652025223,
0.6755736470222473,
-0.25738710165023804,
-0.5075797438621521,
1.4335464239120483,
0.57399582862854,
0.7241968512535095,
-0.10523376613855362,
0.16422024369239807,
-0.3746783435344696,
-0.23667769134044647,
1.208612084388733,
-1.0131126642227173,
-0.06769717484712601,
1.9496735334396362,
-0.14259782433509827,
0.8898168206214905,
0.1466275006532669,
1.367249608039856,
-0.47126662731170654,
0.09072352200746536,
-0.13062472641468048,
-0.08913554251194,
0.02969462424516678,
-0.16749504208564758,
-0.7421768307685852,
-0.36791548132896423,
0.573779284954071,
-0.1307569444179535,
0.22944262623786926,
-0.28814390301704407,
-0.05833561718463898,
0.22252856194972992,
-0.09807375073432922,
0.542273223400116,
0.42872366309165955,
0.07823505252599716,
1.0176975727081299,
0.5587142705917358,
0.054891474545001984,
-0.3861037492752075,
-0.3372115194797516,
-0.5051186680793762,
-0.25563114881515503,
0.5323917865753174,
-0.3252120614051819,
-1.3935168981552124,
0.3863707184791565,
0.5775687098503113,
-1.3795150518417358,
1.066603183746338,
-0.7422249913215637,
0.19912859797477722,
0.5413652062416077,
-0.5376502275466919,
0.6138546466827393,
-0.13933266699314117,
-0.18681159615516663,
-1.0466293096542358,
-0.6426764130592346,
-0.3868403434753418,
-1.2495218515396118,
-0.3075409233570099,
-1.0175931453704834,
-0.8642808198928833,
-0.5570301413536072,
0.1998482495546341,
0.19400647282600403,
-0.7819681167602539,
-0.5487409830093384,
0.6049156188964844,
-0.3998938798904419,
-0.3331943452358246,
0.036809902638196945,
0.15669777989387512,
0.37117496132850647,
0.9934403300285339,
0.3642433285713196,
0.08802073448896408,
-0.2193450629711151,
0.9188458919525146,
1.0950124263763428,
-0.9557735323905945,
-0.32691869139671326,
-0.06719788908958435,
-0.07079822570085526,
0.2410585731267929,
-0.07225341349840164,
-0.23406630754470825,
-0.8365366458892822,
-0.5519679188728333,
-0.16880078613758087,
0.08576982468366623,
-0.5086247324943542,
-0.7343212962150574,
-0.8553420305252075,
-0.528312087059021,
1.1823234558105469,
-0.028555678203701973,
-0.47005417943000793,
0.8273293972015381,
0.14601710438728333,
-0.6784523725509644,
0.8205691576004028,
-1.2976620197296143,
-0.3937893807888031,
0.18915893137454987,
-0.0792517438530922,
-1.1735464334487915,
-0.4664086699485779,
-0.027609894052147865,
0.4717825949192047,
0.2480839639902115,
-0.1569433957338333,
-0.4219702184200287,
-0.006681628990918398,
0.17307612299919128,
-0.04650923237204552,
-0.20279866456985474,
-0.07082662731409073,
-0.3946956992149353,
-0.1890561878681183,
-0.06666042655706406,
-0.6629087924957275,
0.17239674925804138,
-0.31775176525115967,
0.07686494290828705,
0.33214041590690613,
0.6436569690704346,
0.6697070002555847,
-0.11626330763101578,
0.2151532620191574,
-0.0389157198369503,
0.8330477476119995,
-0.2622539699077606,
-0.28882095217704773,
0.5150233507156372,
0.511391282081604,
0.20513233542442322,
-0.20514744520187378,
-0.09761200100183487,
-0.0827474296092987,
0.06704531610012054,
-0.26177045702934265,
-0.8705294728279114,
0.23275980353355408,
-0.19441097974777222,
-0.5297476649284363,
-0.43567562103271484,
0.03126306086778641,
-0.24929508566856384,
0.05342457816004753,
0.23185831308364868,
0.3473632037639618,
0.22159114480018616,
-0.19267447292804718,
-0.30764877796173096,
-0.35119232535362244,
0.467241495847702,
0.16184167563915253,
0.3788609802722931,
0.18864895403385162,
-0.17830047011375427,
0.002974370727315545,
0.15707997977733612,
-0.2089785486459732,
-0.31226029992103577,
-0.04002147167921066,
-0.12580299377441406,
0.993383526802063,
0.06060922518372536,
0.41171807050704956,
0.1417364478111267,
-0.0942329540848732,
0.36726632714271545,
0.16292183101177216,
0.042656850069761276,
-0.10292908549308777,
-0.11803794652223587,
-0.3854883909225464,
-0.08017852902412415,
-0.454947292804718,
0.003938459791243076,
0.18862929940223694,
-0.44140034914016724,
-0.4125766456127167,
-0.22070391476154327,
0.2443581521511078,
0.06301526725292206,
0.43107250332832336,
0.2383001446723938,
-0.08910559117794037,
0.07802940160036087,
0.13418789207935333,
-0.018239669501781464,
-0.7324670553207397,
0.3779468536376953,
0.04296538978815079,
-0.09110794961452484,
0.2496025264263153,
0.37917560338974,
0.031511448323726654,
-0.022025091573596,
-0.5456631183624268,
0.28224945068359375,
-0.1138981431722641,
-0.09667285531759262,
-0.0038934035692363977,
0.44961050152778625,
-0.0087071992456913,
-0.4370245039463043,
0.022567838430404663,
0.43265753984451294,
0.07352552562952042,
0.15800553560256958,
0.3027823269367218
] |
6,822,657 |
Suppression of basal and stimulated noradrenergic activities by the dopamine agonist bromocriptine in man.
|
Carey R M RM, Van Loon G R GR, Baines A D AD, Kaiser D L DL
|
The Journal of clinical endocrinology and metabolism . Vol. 56, No. 3, 1983 Mar
|
This study was designed to determine the effects of dopaminergic receptor stimulation on basal and stimulated catecholamine release in man. Five normal white male volunteer subjects were studied in metabolic balance at constant 150-meq sodium, 60-meq potassium intake and then daily for 8 days on an isocaloric constant diet of 10 meq sodium and 60 meq potassium/day in each of two separate protocols. In one protocol, the subjects received the dopamine agonist bromocriptine for 14 days before and during the study; in the other protocol, placebo was substituted for bromocriptine. During normal sodium intake, bromocriptine suppressed supine plasma norepinephrine concentrations from 193 +/- 10 to 159 +/- 9 pg/ml (P = 0.01). Dietary sodium depletion increased supine plasma norepinephrine concentrations in subjects taking placebo from 193 +/- 10 to 229 +/- 10 pg/ml (P less than 0.001). Bromocriptine prevented the supine plasma norepinephrine response to sodium depletion. After discontinuation of bromocriptine treatment, supine plasma norepinephrine concentrations returned to placebo control values. Upright posture stimulated an increase in plasma norepinephrine concentrations from 193 +/- 10 to 419 +/- 30 pg/ml (P = 0.0001) during normal sodium intake, and bromocriptine suppressed this response from 419 +/- 30 to 286 +/- 29 pg/ml (P = 0.004). Dietary sodium depletion enhanced the plasma norepinephrine response to upright posture, and bromocriptine markedly suppressed this enhancement. After discontinuation of bromocriptine treatment, supine and upright plasma norepinephrine concentrations returned to placebo control values. Bromocriptine induced a parallel downward shift in the inverse hyperbolic relationship between the plasma norepinephrine concentration and urinary sodium excretion in erect subjects, and decreased overnight urinary norepinephrine excretion in supine subjects from 1.1 +/- 0.1 to 0.6 +/- 0.1 ng/h (P = 0.0002). No consistent effects of bromocriptine on plasma epinephrine or dopamine concentrations were observed. The results of this study strongly suggest an inhibitory action of dopamine receptor stimulation by bromocriptine on basal and stimulated norepinephrine output at noradrenergic nerve terminals in the central nervous system and/or the periphery.
|
https://pubmed.ncbi.nlm.nih.gov/6822657/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] |
6822657
|
[
-0.3404996991157532,
0.278991162776947,
-2.8349082469940186,
-2.517939329147339,
0.8111603856086731,
-0.24312080442905426,
1.2436474561691284,
0.2657260298728943,
-0.3526107966899872,
-0.43494606018066406,
-0.43620744347572327,
1.7090272903442383,
0.101716548204422,
0.9308062791824341,
1.6229430437088013,
-0.7668898105621338,
-2.245861768722534,
0.51402747631073,
0.8495009541511536,
-2.4379615783691406,
1.882448673248291,
-1.9588654041290283,
-1.0468354225158691,
-0.6302672028541565,
0.35857006907463074,
0.16780805587768555,
-0.6602689027786255,
0.3776387572288513,
0.900142252445221,
0.790969967842102,
0.2600312829017639,
0.6145380735397339,
1.3396018743515015,
-0.5012925863265991,
-0.3684692680835724,
0.38071197271347046,
1.3993629217147827,
-0.9209151268005371,
0.5463190674781799,
-0.07304473966360092,
0.5876016020774841,
0.9856761693954468,
0.35003170371055603,
0.6305269002914429,
0.8711345791816711,
-0.2674223780632019,
-0.46243712306022644,
-0.4668120741844177,
1.8564274311065674,
0.08000048249959946,
-1.5769765377044678,
0.20374999940395355,
-1.883188009262085,
-0.9430315494537354,
2.024507761001587,
-0.10386684536933899,
0.8114661574363708,
0.38061317801475525,
0.9053856134414673,
-1.0603094100952148,
0.10752501338720322,
-0.32891756296157837,
0.03332417085766792,
0.4448060989379883,
-0.1538747400045395,
0.17527584731578827,
1.2365998029708862,
-0.49750202894210815,
-1.208605170249939,
0.45263606309890747,
-0.4408046305179596,
-0.07151563465595245,
-0.01636004075407982,
0.19596654176712036,
2.2049050331115723,
0.8944644331932068,
-0.4667205214500427,
0.8317256569862366,
0.8865395784378052,
0.7618679404258728,
-1.352935552597046,
-0.472538560628891,
-0.43486452102661133,
-0.7042642831802368,
-0.004234550055116415,
-0.690567135810852,
-0.6320353746414185,
-0.3404559791088104,
0.343159943819046,
-0.327640563249588,
0.14806173741817474,
-1.3708237409591675,
-1.5089492797851562,
0.7081493139266968,
0.16650667786598206,
0.4581858515739441,
-0.7118410468101501,
0.8518129587173462,
-0.9152270555496216,
-0.09967418015003204,
0.44290485978126526,
0.5782408714294434,
-0.0525488518178463,
-0.265369713306427,
0.07915788143873215,
-0.2299714982509613,
-0.05428915098309517,
-1.1743124723434448,
0.014600275084376335,
-1.1861873865127563,
-0.4330485165119171,
-0.036070987582206726,
-0.2728407680988312,
-1.1062374114990234,
0.628858208656311,
0.1719028651714325,
-1.3450422286987305,
-0.029005976393818855,
-0.1864621341228485,
-0.5271487832069397,
1.2371717691421509,
0.726112425327301,
-0.7277743816375732,
0.6055349111557007,
-0.22430036962032318,
-0.36544981598854065,
-0.071650430560112,
-0.6268419623374939,
0.19255125522613525,
-1.1771036386489868,
-0.5647058486938477,
0.6158620715141296,
-0.14362458884716034,
-0.5282248258590698,
-0.5782871246337891,
-0.7016180157661438,
-0.15047690272331238,
-0.01596754416823387,
-0.20073899626731873,
-0.32092973589897156,
-1.0485256910324097,
0.7799239158630371,
-0.12315009534358978,
0.08696697652339935,
-1.0675333738327026,
0.34042850136756897,
-0.12729592621326447,
0.31198200583457947,
0.0956624299287796,
0.120145782828331,
0.01726493611931801,
0.6593061089515686,
0.030037786811590195,
-0.7767282128334045,
-0.12496398389339447,
-0.691165030002594,
-0.11064395308494568,
0.37798112630844116,
0.26655128598213196,
-0.13718409836292267,
0.06879159808158875,
0.11402714997529984,
-0.6493643522262573,
-0.36250901222229004,
0.5748628377914429,
0.05919313430786133,
-0.24570932984352112,
-0.4300900399684906,
0.15869340300559998,
-0.5790603756904602,
-0.4581766128540039,
-0.4019172787666321,
-0.2373916506767273,
0.4103127419948578,
-0.7957331538200378,
-0.5741570591926575,
0.07841600477695465,
0.24967458844184875,
0.14656107127666473,
0.2656711935997009,
-0.4131324887275696,
0.6511035561561584,
-0.00700027123093605,
-0.5934227108955383,
-0.041206132620573044,
-0.36643925309181213,
-0.26555511355400085,
-0.6919198036193848,
-0.02333332970738411,
0.029510967433452606,
-0.18069544434547424,
-0.2729286849498749,
-0.44450658559799194,
-0.03301459178328514,
0.2827906012535095,
-0.3230341970920563,
-0.35574010014533997,
-0.3274341821670532,
-0.11966771632432938,
-0.012131243012845516,
-0.2969150245189667,
0.6072410345077515,
-0.8306887149810791,
0.2075517475605011,
-0.03137897700071335,
-0.5553067922592163,
0.0938088595867157,
0.0707530826330185,
0.28530704975128174,
0.4596472382545471,
0.018243936821818352,
-0.26788395643234253,
0.15171003341674805,
0.2863675057888031,
0.5833920240402222,
0.09180797636508942,
-0.4281219244003296,
0.12203838676214218,
-0.06540000438690186,
0.1083780825138092,
-0.3036792278289795,
-0.31812745332717896,
-0.22137299180030823,
0.018987249583005905,
-0.40126681327819824,
-0.5015254616737366,
-0.47067293524742126,
0.07338377088308334,
-0.18702879548072815,
0.21859151124954224,
-0.2809743881225586,
0.1061733067035675,
0.06748303025960922,
-0.43682408332824707,
-0.21640221774578094,
0.24166886508464813,
-0.2700074315071106,
0.19299417734146118,
-0.05059881880879402,
-0.17169691622257233,
0.016768645495176315,
-0.2722214162349701,
-0.15635614097118378,
-0.14601141214370728,
0.4567123353481293,
-0.19619792699813843,
0.10676829516887665,
-0.08782394230365753,
0.21742336452007294,
-0.3490580916404724,
-0.0659552663564682,
-0.1924879550933838,
-0.23150156438350677,
0.6079154014587402,
0.07311519980430603,
0.16146346926689148
] |
6,823,418 |
Feeding the low-birth-weight infant: I. Taurine and cholesterol supplementation of formula does not affect growth and metabolism.
|
Järvenpää A L AL, Räihä N C NC, Rassin D K DK, Gaull G E GE
|
Pediatrics . Vol. 71, No. 2, 1983 Feb
|
Taurine and cholesterol are constituents of human milk that are present in smaller amounts in infant formulas. Infants fed such formulas have lower plasma and urine concentrations of taurine and of serum total cholesterol. In the present investigation, in infants of 31 to 36 weeks gestational age, the effects of supplementing a 1.5 g/100 mL whey-predominant formula with taurine alone or with taurine plus cholesterol were examined. Infants fed the supplemented formula were compared with infants fed the unsupplemented formula and with infants fed pooled, expressed human milk (185 mL/kg/d). Approximately 45% of the human milk provided to each infant was that of the infant's mother (35% pasteurized and 10% fresh). From the time of reaching a weight of 2,400 g to 4 months of age the last group of infants was fed ad libitum. No consistent statistically significant differences in growth, as measured by rate of gain in crown-rump length, crown-heel length, or head circumference, were observed. There was a tendency, however, for the formula-fed infants to gain weight more slowly before reaching 2,400 g and to gain weight more quickly after a weight of 2,400 g was attained to 4 months of age. No differences in concentrations of BUN, total serum proteins, or acid-base status were observed among the formula-fed groups. The concentration of BUN increased in the formula-fed groups compared with the group fed human milk during the last half of the study. The formula-fed infants tended to have higher total serum proteins and to be slightly more acidotic than the infants fed human milk prior to discharge at a weight of 2,400 g but not thereafter. Thus, infants fed 185 mL/kg/d gained weight at rates comparable to those for fetuses of the same gestational age. Supplementation of formulas with taurine or taurine plus cholesterol did not produce changes in growth or general metabolism discernible under the present experimental conditions.
|
https://pubmed.ncbi.nlm.nih.gov/6823418/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6823418
|
[
0.8263534903526306,
1.8378194570541382,
-1.5022560358047485,
-2.356929302215576,
0.8775119781494141,
1.2073285579681396,
-0.3283662497997284,
-1.2197751998901367,
-1.0658127069473267,
-1.6343514919281006,
2.091905355453491,
1.0905312299728394,
0.37850868701934814,
0.6887108683586121,
-0.7967197299003601,
-1.338960886001587,
-1.5377000570297241,
-0.25313887000083923,
-0.30075350403785706,
-1.5456974506378174,
0.25382548570632935,
-0.06634198129177094,
-0.9843842387199402,
-0.31798186898231506,
1.1181771755218506,
-0.4706360995769501,
0.07133722305297852,
1.5051685571670532,
0.17062129080295563,
-0.26896247267723083,
0.6398979425430298,
-0.887778103351593,
-0.08870264142751694,
-1.4596699476242065,
1.2943241596221924,
-1.6026874780654907,
1.3568414449691772,
-0.869834840297699,
0.07835376262664795,
-0.16321760416030884,
-0.10629972815513611,
0.8028622269630432,
1.1170179843902588,
0.6080455780029297,
0.6849316954612732,
0.23407405614852905,
-0.04349253326654434,
-0.9402022361755371,
0.2857552170753479,
1.2003945112228394,
-0.5577446222305298,
0.9617340564727783,
-1.4255424737930298,
-1.1378004550933838,
1.661209225654602,
0.7815032601356506,
-0.07841535657644272,
-0.2018742561340332,
1.2970763444900513,
-0.40943241119384766,
0.4713745415210724,
0.5905606746673584,
0.06858870387077332,
0.3642820417881012,
-0.5439149141311646,
-0.5698335766792297,
1.1950613260269165,
0.4898952543735504,
-1.2669541835784912,
0.6632206439971924,
0.3618214428424835,
0.08472348004579544,
-0.8301699161529541,
-0.7556870579719543,
0.2664327025413513,
0.16766811907291412,
0.31100818514823914,
1.0275179147720337,
-0.039139363914728165,
0.372645765542984,
-1.399202585220337,
0.5436832904815674,
-0.25938692688941956,
-0.6203401684761047,
0.34435170888900757,
0.673409640789032,
-0.5184789896011353,
0.018707791343331337,
0.513515293598175,
-1.310841679573059,
-0.8477051854133606,
-0.8367550373077393,
-1.2059563398361206,
0.14934788644313812,
-0.21869179606437683,
-0.08376254141330719,
0.12288818508386612,
0.6111786365509033,
-0.10517449676990509,
0.8267437815666199,
0.055749937891960144,
0.1018499881029129,
-0.5052912831306458,
0.1539025753736496,
-0.35087519884109497,
-0.7426217794418335,
-0.1793227195739746,
-0.29806673526763916,
-1.5004587173461914,
-0.5879306793212891,
-0.9569390416145325,
-0.6036706566810608,
0.08883286267518997,
-0.5251148343086243,
0.16948597133159637,
0.09680511057376862,
-0.17580659687519073,
-0.009182119742035866,
0.10757961869239807,
-0.7067036032676697,
0.44316911697387695,
-0.06122194230556488,
-0.21122999489307404,
0.6239997148513794,
-0.052202824503183365,
-0.6297410130500793,
1.307729721069336,
-0.15787911415100098,
-0.5753123760223389,
-0.45466089248657227,
-1.6865512132644653,
0.5630062818527222,
0.47481000423431396,
-0.15848985314369202,
0.23069605231285095,
-0.6259256601333618,
0.08422401547431946,
0.19563142955303192,
0.539422333240509,
-0.7720358371734619,
-0.9134060144424438,
-0.2035297006368637,
-0.8204081654548645,
-0.4203248620033264,
-1.1905527114868164,
0.24846047163009644,
-0.45925450325012207,
-0.34884411096572876,
-0.422162264585495,
0.027271559461951256,
-0.17279204726219177,
0.22936928272247314,
-0.11209574341773987,
0.21986080706119537,
0.18149015307426453,
0.5502225160598755,
0.12433174252510071,
0.4031253755092621,
0.02305644191801548,
0.28865599632263184,
0.863828182220459,
-0.5629453659057617,
0.0340251624584198,
-0.10293760895729065,
0.05546806752681732,
0.06846733391284943,
-0.0746423676609993,
-0.19481012225151062,
-0.4256203770637512,
0.7054996490478516,
-0.11263202875852585,
-0.2521575689315796,
-0.36292126774787903,
0.4910018742084503,
0.22934120893478394,
-0.008971926756203175,
0.36074933409690857,
0.057744868099689484,
0.5437804460525513,
0.04928351193666458,
-0.027153903618454933,
0.4282348155975342,
0.24863667786121368,
-0.37234264612197876,
0.048528626561164856,
-0.7507367134094238,
0.09968443959951401,
-0.28726503252983093,
0.1365785300731659,
-0.5110726952552795,
-0.22150880098342896,
0.5634941458702087,
-0.4363142251968384,
-0.3136446177959442,
0.45750692486763,
0.1372942179441452,
0.5132947564125061,
0.13912343978881836,
0.3192525804042816,
0.5369980335235596,
-0.40955454111099243,
0.06237932667136192,
0.06494466215372086,
0.06455454230308533,
0.06941177695989609,
0.4051191806793213,
-0.30147895216941833,
0.924065113067627,
0.008982773870229721,
0.21230007708072662,
0.538520872592926,
0.1584765911102295,
-0.05223395675420761,
0.30832600593566895,
0.45335882902145386,
0.17004530131816864,
-0.19162455201148987,
0.3917433023452759,
-0.2583608329296112,
0.10256469994783401,
-0.1097279042005539,
0.17369034886360168,
-0.2795712649822235,
-0.10284959524869919,
0.2811652421951294,
0.1160876527428627,
0.057552438229322433,
-0.2112160474061966,
0.3185849189758301,
0.010908706113696098,
-0.36862656474113464,
-0.23435550928115845,
-0.039729200303554535,
0.050998181104660034,
-0.29734498262405396,
-0.12678106129169464,
-0.1920183151960373,
-0.11457444727420807,
0.18737223744392395,
-0.2670840322971344,
-0.014463784173130989,
-0.4686330258846283,
0.036024510860443115,
-0.10429385304450989,
-0.06736985594034195,
-0.4298068881034851,
-0.38542211055755615,
-0.049403123557567596,
-0.2304561734199524,
-0.5463775992393494,
0.2615736722946167,
0.27768760919570923,
0.08605845272541046,
-0.3142849802970886,
-0.010860680602490902,
-0.15210069715976715
] |
6,823,433 |
Cow's milk proteins cause infantile colic in breast-fed infants: a double-blind crossover study.
|
Jakobsson I I, Lindberg T T
|
Pediatrics . Vol. 71, No. 2, 1983 Feb
|
Sixty-six mothers of 66 breast-fed infants with infantile colic were put on a diet free from cow's milk. The colic disappeared in 35 infants; it reappeared on at least two challenges (cow's milk to mother) in 23 infants (35%). A double-blind crossover trial with cow's milk whey protein was performed in 16 of these 23 mothers and infants. Six infants had to be taken out of the study for various reasons; of the remaining ten infants, nine reacted with colic after their mothers' intake of whey protein-containing capsules. Sequential analysis showed a high correlation between infantile colic in breast-fed infants and their mothers' consumption of cow's milk protein. A diet free of cow's milk is suggested for the mothers as a first trial of treatment of infantile colic in breast-fed infants.
|
https://pubmed.ncbi.nlm.nih.gov/6823433/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6823433
|
[
0.9552584290504456,
0.6898357272148132,
0.5463964343070984,
-1.898619532585144,
0.42165884375572205,
2.665400981903076,
-2.0862061977386475,
-1.9692775011062622,
-1.5791621208190918,
-1.241690754890442,
0.9844438433647156,
2.4465792179107666,
-1.3800625801086426,
2.2258193492889404,
-0.052077509462833405,
-1.7157070636749268,
-2.849048614501953,
-0.17786720395088196,
-0.334651917219162,
0.6903421878814697,
1.741062045097351,
-0.0683942660689354,
-1.7959750890731812,
-1.6182643175125122,
1.162160038948059,
-0.784367561340332,
0.5078868269920349,
0.4054264426231384,
-1.585564136505127,
0.3545266389846802,
1.5884978771209717,
0.6917967796325684,
-1.8555796146392822,
-0.5558035969734192,
1.0308878421783447,
-1.7443128824234009,
1.1087864637374878,
-1.1447796821594238,
-1.4039865732192993,
0.35449686646461487,
0.8463283777236938,
-0.6718063950538635,
0.33760884404182434,
1.19362473487854,
0.5394853353500366,
-0.6034128665924072,
1.2065266370773315,
-1.1588969230651855,
-0.5852717757225037,
2.9868948459625244,
-1.650229573249817,
0.784622848033905,
-0.3967381417751312,
-1.1120967864990234,
0.6828526258468628,
0.8629955053329468,
-0.5242322087287903,
-0.36050406098365784,
1.4354617595672607,
0.7501403093338013,
1.1764055490493774,
0.35408851504325867,
0.07377903163433075,
0.17677375674247742,
-0.10176753252744675,
-1.1440203189849854,
1.343125343322754,
0.025999419391155243,
-1.474433183670044,
1.0484678745269775,
0.970619797706604,
1.5967239141464233,
-1.5535876750946045,
0.24654102325439453,
0.1434003710746765,
-0.196440652012825,
1.1146024465560913,
0.3116644620895386,
0.5858866572380066,
0.7540861368179321,
-1.8156663179397583,
-0.18531091511249542,
1.13279390335083,
-0.60283362865448,
0.44156816601753235,
0.8569471836090088,
-1.677114725112915,
0.955951452255249,
0.7213937640190125,
-1.6949646472930908,
-0.48098883032798767,
-0.5751885771751404,
-1.5833479166030884,
0.322459876537323,
0.2476852685213089,
1.067451000213623,
0.7944187521934509,
0.7023933529853821,
-0.019485583528876305,
1.4269181489944458,
-0.36740121245384216,
-0.5098195672035217,
-0.45700424909591675,
0.01665676198899746,
-0.9643213748931885,
0.22684594988822937,
1.1609631776809692,
-0.6664053797721863,
-1.462450623512268,
-0.802379846572876,
-0.5193855166435242,
0.7947626709938049,
0.527385950088501,
-0.4953251779079437,
0.14714522659778595,
-0.13075028359889984,
-0.08889394253492355,
-0.11947986483573914,
0.5697982907295227,
-0.3976619839668274,
-0.16367895901203156,
-0.22147680819034576,
0.02732151933014393,
1.0367025136947632,
-0.15149471163749695,
-1.2711702585220337,
-0.14944873750209808,
0.11274681985378265,
-1.048371434211731,
0.8838510513305664,
-2.168606996536255,
0.3012063503265381,
1.2230795621871948,
-0.1586935818195343,
0.17640471458435059,
-0.20989850163459778,
0.0961376428604126,
0.10776959359645844,
0.20554190874099731,
-1.3863095045089722,
-0.9838511347770691,
0.5787216424942017,
-0.6971275210380554,
-0.39859849214553833,
-1.0204333066940308,
-0.303088515996933,
0.15353688597679138,
-0.05900374427437782,
-0.6503849029541016,
-0.09459417313337326,
-0.010374899953603745,
0.06313726305961609,
0.04149343818426132,
0.27676060795783997,
0.663105309009552,
1.4157098531723022,
0.1990959793329239,
0.005175811238586903,
-0.05848308280110359,
-0.14629888534545898,
1.5730421543121338,
-0.7953067421913147,
0.7829704284667969,
-0.04561533406376839,
-0.646052896976471,
0.6248438954353333,
0.3867802619934082,
-0.23291431367397308,
-0.31639954447746277,
0.9097653031349182,
-0.02771291695535183,
0.32960453629493713,
-0.6918367147445679,
0.6929832100868225,
0.5524989366531372,
-0.637238085269928,
0.8800016641616821,
-0.23021958768367767,
0.3817620873451233,
-0.1084359809756279,
-0.9226383566856384,
0.38592419028282166,
-0.2638937532901764,
-0.16788698732852936,
-0.2468509078025818,
-0.5375128984451294,
0.005852746311575174,
0.46044087409973145,
0.14758837223052979,
-0.6935099959373474,
0.6927070021629333,
-0.008511099964380264,
0.06365027278661728,
-0.43583375215530396,
-0.2932427227497101,
0.35233813524246216,
0.5225366950035095,
-0.10657250881195068,
0.7057186365127563,
0.14955471456050873,
0.5325459241867065,
0.24226394295692444,
-0.4586533308029175,
0.031244540587067604,
0.3668615221977234,
1.2378065586090088,
0.32870057225227356,
0.5520724654197693,
0.27956125140190125,
-0.11306686699390411,
0.9581320285797119,
0.2744889259338379,
-0.06189325079321861,
0.08020558208227158,
-0.2682366371154785,
-0.20499971508979797,
-0.2954767942428589,
0.13163122534751892,
-0.1414220780134201,
-0.4120113253593445,
-0.31256726384162903,
0.3736123740673065,
0.1478615701198578,
0.20776064693927765,
0.8556225895881653,
0.4933406412601471,
-0.05633865296840668,
0.03792684152722359,
0.16947993636131287,
-0.17413905262947083,
-0.13272356986999512,
-0.19283388555049896,
-0.5585052371025085,
0.37178370356559753,
-0.6321663856506348,
0.2517332136631012,
0.19007934629917145,
0.5117056965827942,
0.020220177248120308,
0.2710535228252411,
-0.11370959877967834,
-0.33928000926971436,
-0.04527571052312851,
0.05705114081501961,
-0.281379371881485,
-0.43676066398620605,
-0.5944930911064148,
0.5834300518035889,
0.11036546528339386,
-0.8447839617729187,
-0.27582040429115295,
0.7671301364898682,
0.7937589883804321,
-0.8666293621063232,
0.48108676075935364,
-0.36829674243927
] |
6,823,470 |
Effect of electromyographic biofeedback on an isometric strengthening program.
|
Lucca J A JA, Recchiuti S J SJ
|
Physical therapy . Vol. 63, No. 2, 1983 Feb
|
An evaluation was carried out of the strength gains after a 19-day training program that consisted of isometric exercise coupled with electromyographic biofeedback to the knee extensor muscles. The subjects were 30 female undergraduate students who were randomly assigned to one of three groups. The experimental group performed isometric exercise and received electromyographic biofeedback, another group performed isometric exercise without receiving biofeedback, and the control group performed no exercises other than the pretest and posttest. The combination of biofeedback and isometric exercise was shown to produce greater gains in peak torque than isometric exercise alone over a 19-day training period. The authors believe that this study may provide a strong rationale for the clinical use of biofeedback.
|
https://pubmed.ncbi.nlm.nih.gov/6823470/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6823470
|
[
-2.07074236869812,
2.3420627117156982,
-2.3826656341552734,
-3.9202382564544678,
1.3751038312911987,
1.417901635169983,
-0.9550551772117615,
0.18046167492866516,
-0.34812381863594055,
-1.0497076511383057,
-0.06729236245155334,
1.2805384397506714,
-0.2911036014556885,
0.9786477088928223,
-0.5177513957023621,
1.1695454120635986,
-0.5759090781211853,
-1.4564861059188843,
1.0660806894302368,
-1.1161994934082031,
-0.849776566028595,
0.5495942831039429,
-0.7218450307846069,
0.07348256558179855,
0.7860866189002991,
-0.25400060415267944,
0.26541513204574585,
1.2149981260299683,
-0.14008353650569916,
1.0423429012298584,
0.5201724767684937,
-0.6417510509490967,
0.6554352641105652,
-0.7271603345870972,
-1.1708738803863525,
-0.24643005430698395,
1.0069249868392944,
-0.5919908285140991,
-1.4936487674713135,
-0.5385904312133789,
-0.4454972445964813,
1.6895971298217773,
-0.055379513651132584,
0.8387511372566223,
1.0590780973434448,
-0.1021890789270401,
0.5558567643165588,
0.21798934042453766,
-0.6032819151878357,
0.44364267587661743,
-0.07726228982210159,
-0.0643358826637268,
-0.23390209674835205,
0.2939375042915344,
2.6154870986938477,
-0.18948887288570404,
0.6936682462692261,
-0.2945895493030548,
-0.0944843515753746,
0.8937003016471863,
1.0510915517807007,
0.17379848659038544,
0.5638555288314819,
0.13804267346858978,
0.3892521262168884,
-1.9907945394515991,
1.2393583059310913,
1.0184868574142456,
-0.9417682886123657,
0.8234946727752686,
1.1162914037704468,
0.1598690152168274,
0.8984618186950684,
1.545650601387024,
-0.12643033266067505,
-0.5605814456939697,
-0.5030856728553772,
0.3102453351020813,
0.6154899001121521,
0.3760382831096649,
0.6546909809112549,
-1.2418383359909058,
-0.7218185067176819,
0.5375245809555054,
0.290223091840744,
0.25585734844207764,
-0.5397437810897827,
0.42617860436439514,
0.5100671648979187,
-0.3581044375896454,
-0.22109931707382202,
-0.22640864551067352,
-0.4402092695236206,
-0.3012121915817261,
0.18003520369529724,
0.5581992268562317,
-0.494137167930603,
-0.6087838411331177,
0.4671277105808258,
0.7092123031616211,
-0.40608933568000793,
1.0373247861862183,
0.22256027162075043,
-0.4429176449775696,
-0.2536630630493164,
-1.0410410165786743,
-0.918578028678894,
-0.3679318130016327,
0.7348966598510742,
-0.07283481955528259,
0.6327952742576599,
-0.23984083533287048,
0.42356497049331665,
0.3925026059150696,
0.5262307524681091,
-0.01999637857079506,
0.8037788271903992,
0.6944565773010254,
0.6138901710510254,
-0.18283480405807495,
0.2311989814043045,
1.557822585105896,
0.740161120891571,
0.2350894659757614,
-0.7049401998519897,
0.7684076428413391,
0.3574933111667633,
-0.28891441226005554,
-0.2301233410835266,
-0.6525442600250244,
-1.6106492280960083,
-0.7001879215240479,
0.42792385816574097,
-0.25859519839286804,
-1.7785629034042358,
0.18293464183807373,
0.5002585053443909,
0.6033145785331726,
-0.0755976140499115,
0.5688790082931519,
-0.3365667164325714,
0.3558422327041626,
0.14840638637542725,
0.28674232959747314,
-0.32745349407196045,
-0.10464009642601013,
-0.49428194761276245,
-0.14943449199199677,
0.13924984633922577,
0.7419303059577942,
-0.48764941096305847,
-0.3454643785953522,
0.7837510704994202,
0.4274720549583435,
-0.5289189219474792,
-0.7157340049743652,
-0.48461127281188965,
-0.07220032811164856,
0.5234783887863159,
-0.10133806616067886,
0.447262704372406,
-0.020187996327877045,
0.41913941502571106,
-0.05749022215604782,
0.5686272978782654,
-0.337938517332077,
0.0687776580452919,
0.5014370679855347,
1.1958940029144287,
0.18209949135780334,
-0.5383895635604858,
0.4155862033367157,
0.7287867069244385,
0.1351364105939865,
0.28833451867103577,
1.0584262609481812,
0.933800458908081,
0.6615408062934875,
0.44875428080558777,
-0.6723638772964478,
-0.24916744232177734,
0.2700763940811157,
0.1447046548128128,
-0.0009265701519325376,
0.09707906097173691,
-0.23225247859954834,
0.5672216415405273,
-0.8444101810455322,
-0.26875776052474976,
0.0422990508377552,
-0.3637804388999939,
0.7698207497596741,
0.029202865436673164,
-0.06063732132315636,
-0.3280279040336609,
-0.03559393435716629,
-0.11257544904947281,
-0.3724209666252136,
0.37048962712287903,
-0.15431933104991913,
0.0022464266512542963,
0.14169494807720184,
-0.33851420879364014,
-0.23977044224739075,
-0.13049408793449402,
0.2747627794742584,
-0.4117968678474426,
0.20165643095970154,
0.4154220521450043,
0.1814553439617157,
0.058304931968450546,
0.4017559587955475,
0.15676449239253998,
0.12391786277294159,
0.47949397563934326,
0.6415024995803833,
-0.3477608859539032,
0.23212024569511414,
-0.14679889380931854,
0.46165674924850464,
0.2989100515842438,
-0.6806028485298157,
-0.01495452132076025,
-0.0005272743874229491,
-0.16694548726081848,
-0.38479384779930115,
-0.13700222969055176,
0.0317387655377388,
-0.18142199516296387,
0.2985531687736511,
-0.40062958002090454,
0.3072092831134796,
-0.3576267957687378,
0.457179456949234,
-0.14937831461429596,
0.14362744987010956,
-0.03640103340148926,
0.19393819570541382,
-0.11932744830846786,
0.11667844653129578,
0.08124323189258575,
-0.5963643789291382,
0.12453614920377731,
-0.5888331532478333,
0.32516756653785706,
-0.3784540295600891,
-0.07931654900312424,
0.6066077947616577,
0.299667090177536,
-0.16074427962303162,
-0.34889528155326843,
0.22573713958263397,
0.27382194995880127,
0.2523626983165741,
0.17714457213878632,
-0.36878183484077454
] |
6,823,474 |
Supervised versus independent student laboratories.
|
Kloth L C LC, Morrison M A MA
|
Physical therapy . Vol. 63, No. 2, 1983 Feb
|
The purpose of this study was to determine if classroom laboratory time could be reduced in a basic physical agents course. Fifty-seven junior physical therapy students were randomly assigned to three laboratory sections. All students received identical lectures, demonstrations, course materials, and laboratory manuals. The control group, Section 1, received supervision and assistance during laboratory practice. Students in Section 2 and Section 3 worked independent of instructor supervision but could receive assistance from the instructor in an adjacent room. Students in Section 2 were provided with feedback following periodic assessment by the instructor. Attitudinal questionnaire responses indicated that the students preferred the supervised laboratory section. The presence of the instructor during classroom laboratory practice of basic physical agents did not affect student performance. Comparison of written and practical examination results indicated no significant differences in student performance. Classroom laboratory time for faculty and students was reduced when students worked independently.
|
https://pubmed.ncbi.nlm.nih.gov/6823474/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6823474
|
[
0.24342556297779083,
6.318271160125732,
-2.0117509365081787,
-1.6864128112792969,
-0.24165275692939758,
0.2518702447414398,
-1.030489206314087,
-0.9364100098609924,
-0.6301142573356628,
-0.41661450266838074,
0.08827023953199387,
0.9067588448524475,
-1.23960542678833,
1.8305050134658813,
-1.7402552366256714,
-0.1364651769399643,
0.4135085642337799,
-0.28530997037887573,
0.9135988354682922,
0.6391819715499878,
-0.6016477346420288,
1.1308581829071045,
-1.2304465770721436,
-1.3748514652252197,
0.24079935252666473,
1.6431527137756348,
0.3996720612049103,
1.9547290802001953,
0.3341118395328522,
0.9184656739234924,
1.1642268896102905,
1.2809724807739258,
0.596626877784729,
-0.4525522291660309,
-1.0381014347076416,
-0.001246051979251206,
-0.42971694469451904,
1.0106637477874756,
-0.30947843194007874,
0.09134566783905029,
0.7398368120193481,
0.4373360872268677,
0.003604582278057933,
-0.9344112873077393,
-0.226685032248497,
-0.16293556988239288,
-0.42000076174736023,
-0.43124067783355713,
0.017178267240524292,
0.27184629440307617,
0.36149659752845764,
1.0394079685211182,
-0.32669833302497864,
-0.6040062308311462,
1.3234002590179443,
0.7255412936210632,
0.7591920495033264,
-1.1749831438064575,
1.2642742395401,
-0.8012592792510986,
0.4075653553009033,
0.7241314649581909,
2.2814133167266846,
0.34288454055786133,
-0.7045930027961731,
-1.0638415813446045,
0.38443514704704285,
0.6180139780044556,
-2.061267375946045,
0.5793983340263367,
0.8084231615066528,
0.7533925771713257,
1.4238743782043457,
0.9208793044090271,
1.268163800239563,
0.10517697781324387,
-0.8152267336845398,
0.060809046030044556,
0.47740641236305237,
0.35333824157714844,
0.23861615359783173,
-1.2443968057632446,
-0.6454616189002991,
-0.2720232605934143,
1.955148696899414,
0.17452988028526306,
-1.0214784145355225,
-0.021459417417645454,
-0.33541619777679443,
0.661596953868866,
0.579892635345459,
0.24438554048538208,
-0.45013660192489624,
0.3056400418281555,
-0.34129059314727783,
0.12276044487953186,
1.1419163942337036,
-0.8010261058807373,
0.6162812113761902,
0.04010922834277153,
-0.08382412791252136,
-0.338783323764801,
1.4783083200454712,
0.39357659220695496,
0.9531976580619812,
-1.5279728174209595,
-0.3876529633998871,
-0.19761741161346436,
-0.30457767844200134,
-0.10263823717832565,
-1.0756911039352417,
0.013204563409090042,
0.8132995367050171,
-0.36145973205566406,
0.6437661647796631,
-1.5240150690078735,
1.0041793584823608,
-1.2082616090774536,
0.8654501438140869,
0.27732667326927185,
0.31215420365333557,
1.46085786819458,
-0.4775541424751282,
0.8042909502983093,
-0.5085479617118835,
-0.08128208667039871,
-0.310406893491745,
-0.7448054552078247,
-0.6958017349243164,
-1.3354113101959229,
-0.3286955654621124,
-1.115744948387146,
0.8705779314041138,
-0.3573070466518402,
-0.6130321025848389,
-1.5059435367584229,
0.12913808226585388,
0.24517330527305603,
-0.37793630361557007,
-0.0444980151951313,
-0.36760932207107544,
0.3848738968372345,
1.0710675716400146,
-0.3990195691585541,
-0.825130820274353,
1.1714004278182983,
-0.2452882081270218,
-0.6523642539978027,
0.3190006613731384,
1.027513861656189,
-0.5363607406616211,
0.7819550037384033,
-0.6452465653419495,
0.08992545306682587,
-0.8342133164405823,
-0.6289046406745911,
0.754499077796936,
-0.15805980563163757,
0.2302987426519394,
-0.21795161068439484,
1.585805058479309,
0.05569189041852951,
-0.2169930338859558,
0.003434983314946294,
0.7016810178756714,
-0.5963318347930908,
-0.4225783944129944,
0.7327653765678406,
0.577429473400116,
0.2225186973810196,
-0.24980945885181427,
0.060496069490909576,
-0.20828600227832794,
0.3878747224807739,
0.22205859422683716,
0.6161360740661621,
-0.22561903297901154,
-0.5036674737930298,
0.6100916862487793,
0.4082631766796112,
0.5326769351959229,
0.02329360879957676,
0.04374658688902855,
0.09153185039758682,
-0.565559983253479,
-0.024023031815886497,
0.4506082236766815,
-0.2491036355495453,
-0.10681892186403275,
0.029801731929183006,
-0.2566584646701813,
0.02094121463596821,
-0.12714456021785736,
0.19386975467205048,
0.734001100063324,
-0.013426781632006168,
-0.7342568635940552,
0.05240913853049278,
0.5002666115760803,
0.04552715644240379,
0.06522946804761887,
0.557933509349823,
0.14687702059745789,
0.8173531889915466,
-0.1427382379770279,
-0.9679197669029236,
-0.719289243221283,
-0.2414187788963318,
-0.020157217979431152,
1.2545371055603027,
-0.20187290012836456,
-0.5131317973136902,
-0.03841659054160118,
0.530340313911438,
0.5708003640174866,
0.4768189489841461,
0.8392793536186218,
-0.22308559715747833,
-0.4638492465019226,
-0.6889016032218933,
-0.03492623567581177,
-0.8041757345199585,
-0.22294452786445618,
-0.4484666585922241,
-0.7746214270591736,
0.1050371378660202,
0.1368253231048584,
-0.03769723325967789,
-0.5625507831573486,
-0.16136379539966583,
0.19547902047634125,
0.19100847840309143,
-0.22240497171878815,
0.1395179182291031,
0.30084753036499023,
0.533089816570282,
-0.02713456191122532,
-0.21133160591125488,
0.0392487458884716,
0.4084796905517578,
0.07797043025493622,
-0.40533262491226196,
-0.006843868177384138,
-0.36674779653549194,
-0.25883355736732483,
0.2760339379310608,
-0.041767098009586334,
0.33080199360847473,
0.14525645971298218,
0.5319821834564209,
-0.1672973483800888,
0.11933430284261703,
-0.11923690885305405,
0.04583541303873062,
0.016260841861367226,
-0.47591862082481384
] |
6,823,476 |
A randomized comparison of triangular and rotation-advancement unilateral cleft lip repairs.
|
Holtmann B B, Wray R C RC
|
Plastic and reconstructive surgery . Vol. 71, No. 2, 1983 Feb
|
We prospectively and randomly compared triangular and rotation-advancement unilateral cleft lip repairs in 35 patients. The most significant difference between the two repairs noted in this series was a greater frequency of hypertrophic scars following rotation-advancement repairs. The overall appearance of the lip and nose postoperatively was the same in both groups.
|
https://pubmed.ncbi.nlm.nih.gov/6823476/
|
[
"Case Reports",
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6823476
|
[
-1.000733494758606,
0.7623050808906555,
-1.9847443103790283,
-1.2145054340362549,
-0.2894090712070465,
0.9975072741508484,
-0.14814139902591705,
-1.2111903429031372,
-1.46381676197052,
0.829511821269989,
-0.16397559642791748,
-0.33023709058761597,
-0.9493858218193054,
-0.6099784970283508,
-0.8914809226989746,
1.5121066570281982,
-0.31033191084861755,
0.4573419392108917,
-0.5401607751846313,
-0.6534426808357239,
-0.8347185254096985,
0.9949975609779358,
1.6265367269515991,
-1.031540870666504,
0.8530260324478149,
-0.8229512572288513,
-0.07335215061903,
0.9119685888290405,
-0.5819923281669617,
-0.24069640040397644,
0.15008406341075897,
0.11403099447488785,
-1.130018711090088,
0.8965714573860168,
-0.7078825831413269,
-0.7961284518241882,
-0.7512021660804749,
-1.2438673973083496,
-0.27885380387306213,
0.14301714301109314,
1.3074928522109985,
-0.1636698991060257,
0.6065621376037598,
-0.9447582960128784,
0.628246009349823,
0.8710739016532898,
0.5283415913581848,
-0.23413655161857605,
1.556406021118164,
-1.1413071155548096,
1.779759168624878,
1.4665683507919312,
0.6716671586036682,
-1.0309644937515259,
0.6630579829216003,
0.32372915744781494,
1.453527569770813,
-0.02809986099600792,
0.5556544065475464,
0.2198687493801117,
0.9512524604797363,
-0.07151217013597488,
-0.40973415970802307,
1.2809836864471436,
-1.193055272102356,
0.5564577579498291,
0.5966604351997375,
0.42705342173576355,
-0.6828539967536926,
0.44797322154045105,
-0.6468326449394226,
-1.25344717502594,
-0.03672599792480469,
0.015691107138991356,
1.6812041997909546,
0.6536197662353516,
-0.09096574038267136,
0.14233972132205963,
-0.2284214198589325,
0.04743308946490288,
0.40036264061927795,
-0.5806326270103455,
-0.9498741030693054,
0.3580382466316223,
0.49288997054100037,
-0.8111234903335571,
-1.2151097059249878,
-0.521609902381897,
-0.08190803974866867,
-0.518754243850708,
-0.7266858816146851,
0.5900030136108398,
-1.1885478496551514,
0.2823391556739807,
0.40966564416885376,
0.7021784782409668,
0.7503054738044739,
-0.42092636227607727,
-1.2770568132400513,
0.14007510244846344,
-0.2425566464662552,
0.7411361932754517,
0.3439639210700989,
-1.8461297750473022,
-0.1580255627632141,
-0.6408036351203918,
-0.7772130370140076,
-0.4485620856285095,
-0.8487406969070435,
-0.3410288691520691,
-0.44064342975616455,
-1.001793384552002,
-0.7966551780700684,
-0.18919745087623596,
-0.043982360512018204,
-0.027941474691033363,
-0.15776139497756958,
-0.057840123772621155,
0.1679859161376953,
-0.6229809522628784,
0.13818144798278809,
0.3352052569389343,
0.38481855392456055,
-0.16927529871463776,
-0.12835729122161865,
-0.23509567975997925,
0.2064683437347412,
1.5605217218399048,
-0.5083098411560059,
0.32132843136787415,
0.5056485533714294,
0.6903063654899597,
-0.251809686422348,
-0.5325098633766174,
-1.4654529094696045,
-0.13256248831748962,
0.249616339802742,
0.4256385862827301,
0.33828476071357727,
-0.33500245213508606,
0.3779728412628174,
-0.6663846373558044,
-0.00331612559966743,
0.7958441972732544,
-0.04696955159306526,
-0.16565024852752686,
0.8964414596557617,
0.9229924082756042,
-1.207140326499939,
0.5563313364982605,
0.4252486526966095,
0.3976505994796753,
1.4372344017028809,
0.15231797099113464,
0.3832993805408478,
0.4179566502571106,
0.4395616054534912,
-1.0589210987091064,
0.23781369626522064,
1.04747474193573,
0.9006388783454895,
0.151802659034729,
0.17376630008220673,
-0.4667665660381317,
0.9461231231689453,
-0.6752483248710632,
0.3177408277988434,
-0.8219432830810547,
-0.18658187985420227,
0.517693817615509,
-0.5777953863143921,
-0.015584244392812252,
0.19200965762138367,
0.3924519717693329,
-0.7731201648712158,
0.28947213292121887,
1.0939507484436035,
0.25793951749801636,
0.2509658634662628,
-0.3597204089164734,
0.04219038411974907,
-0.12121740728616714,
0.7405422329902649,
-0.05208015814423561,
-0.527705192565918,
-0.7844322919845581,
0.6440877318382263,
-0.456150621175766,
-0.2066461443901062,
0.3958543837070465,
0.2434159368276596,
0.05138380452990532,
0.1177092120051384,
-0.11286979913711548,
0.4139799177646637,
0.367737352848053,
-0.6526938080787659,
-0.1696130931377411,
0.24328652024269104,
0.05442766845226288,
0.0903831496834755,
-0.1986023187637329,
-0.4212263822555542,
0.2152288556098938,
0.45803508162498474,
-0.5224326848983765,
-0.6157776117324829,
0.16787263751029968,
-1.0501604080200195,
0.27249395847320557,
-0.32751575112342834,
-0.0963212177157402,
0.09770005196332932,
0.3004036545753479,
-0.3141002953052521,
0.08359517902135849,
-0.013282530941069126,
-0.013561963103711605,
-1.0518531799316406,
0.008575375191867352,
1.2249433994293213,
0.8660381436347961,
-0.06070038303732872,
0.16186393797397614,
0.08801566064357758,
-0.11200445145368576,
0.10287332534790039,
0.23653589189052582,
0.6335895657539368,
-0.2294735312461853,
-0.4503418505191803,
-0.09725964069366455,
0.07454974204301834,
-0.09264696389436722,
0.2612258493900299,
0.4292443096637726,
0.16152286529541016,
-0.7914279699325562,
0.022542845457792282,
0.13705550134181976,
-0.04386011138558388,
-0.5880006551742554,
-0.8361865878105164,
-0.24030010402202606,
0.5599920153617859,
0.06498895585536957,
0.12918120622634888,
0.5054699182510376,
-0.18616707623004913,
0.6156570315361023,
-0.0773574709892273,
0.19601021707057953,
0.453610897064209,
0.6384217143058777,
0.009581485763192177,
0.11117767542600632
] |
6,823,630 |
Epidural versus intramuscular pethidine in postoperative pain relief.
|
Payne K A KA
|
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde . Vol. 63, No. 6, 1983 Feb 05
|
Twenty-one patients received epidural pethidine 0,75 mg/kg in 10 ml normal saline for postoperative analgesia. A control group of 20 patients received intramuscular pethidine 1,5 mg/kg. Respiratory and cardiovascular parameters in both groups were stable, and in both side-effects were similar and not serious. In the epidural group analgesia was more intense and of longer duration and the level of consciousness was better. Central depression was present in both groups but less so in the epidural group.
|
https://pubmed.ncbi.nlm.nih.gov/6823630/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6823630
|
[
0.7798919081687927,
0.004379461519420147,
-1.924709677696228,
-2.2444493770599365,
0.4132000207901001,
0.5007288455963135,
1.0507872104644775,
-0.24609436094760895,
-0.9837886095046997,
-0.1653139889240265,
0.91950523853302,
2.380962610244751,
0.48085522651672363,
0.2947361469268799,
-0.3559603989124298,
1.119016170501709,
-0.4918114244937897,
-0.630976140499115,
0.2449517548084259,
-1.057539701461792,
-0.08752040565013885,
-0.43887320160865784,
-1.1309032440185547,
-0.746337354183197,
0.5874327421188354,
-1.2229970693588257,
0.26085737347602844,
0.307698518037796,
0.5557224154472351,
-0.4098827540874481,
-0.016189085319638252,
-1.8799892663955688,
0.8071807026863098,
0.3553086221218109,
-0.48858842253685,
-0.920776903629303,
0.5841639041900635,
0.5191136598587036,
0.10164148360490799,
-0.3289564549922943,
0.8583583235740662,
1.2877885103225708,
0.2805287837982178,
-0.5356994271278381,
0.6625123023986816,
1.1822469234466553,
0.21619705855846405,
0.5171879529953003,
0.2933637201786041,
-0.2701656222343445,
-0.5976588129997253,
0.620651364326477,
-0.3364589512348175,
0.4509062170982361,
1.7277637720108032,
-0.2122115194797516,
1.3087047338485718,
-0.23931148648262024,
1.43529212474823,
-0.24409398436546326,
-1.0609164237976074,
0.3126455247402191,
0.5793955326080322,
-0.3289349377155304,
0.21162374317646027,
-1.0884212255477905,
0.4364984631538391,
0.43929627537727356,
-0.17194236814975739,
1.0865540504455566,
-0.8961685299873352,
0.2534264028072357,
-0.01867271400988102,
-0.13617940247058868,
0.8789916634559631,
0.6352457404136658,
0.12659122049808502,
0.5862186551094055,
0.1289680004119873,
0.5915836095809937,
-0.5910386443138123,
-1.440136432647705,
-0.026102425530552864,
-0.6059020161628723,
-0.09181448072195053,
0.4376702904701233,
-1.2849210500717163,
0.49878746271133423,
-0.2191893458366394,
-0.42924702167510986,
1.439560890197754,
-1.4036589860916138,
-1.4791996479034424,
-0.1073378250002861,
-0.8203716278076172,
0.678291916847229,
-0.29012763500213623,
0.4266289472579956,
-1.0627155303955078,
0.22277042269706726,
0.12515495717525482,
-0.5584427714347839,
0.4675709009170532,
0.302259236574173,
-0.3849831223487854,
-0.42712193727493286,
-0.48543864488601685,
-0.47951140999794006,
-0.3657490909099579,
-0.4534980356693268,
-0.3739939033985138,
-0.1679120510816574,
0.2664984166622162,
-0.9702727794647217,
0.3086441159248352,
0.6284607648849487,
0.2069687694311142,
-0.5439305305480957,
0.0011225225171074271,
-0.9757834076881409,
0.5693962574005127,
1.2982929944992065,
-0.5128891468048096,
0.7041745185852051,
-0.6478622555732727,
-0.22054295241832733,
0.4250543713569641,
0.5960668325424194,
0.6518574357032776,
0.06344974040985107,
-0.5360149145126343,
0.6138026714324951,
0.029553847387433052,
-0.7285037040710449,
-0.8626059293746948,
0.050660140812397,
0.024127230048179626,
1.0210663080215454,
-0.1956651210784912,
-0.0297511275857687,
0.4055916666984558,
0.06773854047060013,
-0.7852250933647156,
0.0572960264980793,
-0.4418846368789673,
0.2210138738155365,
-0.28685232996940613,
-0.5576995015144348,
-0.29047906398773193,
-0.11004044860601425,
-0.4269883930683136,
0.044782087206840515,
0.3359835147857666,
-0.03870448097586632,
-0.560011088848114,
0.4143783152103424,
-0.006502972450107336,
0.6494935750961304,
0.4188743531703949,
-0.19662347435951233,
-0.025076840072870255,
0.0524875707924366,
-0.2734864056110382,
-0.4610341191291809,
0.734065592288971,
0.0868263691663742,
-0.6432188749313354,
0.04467271640896797,
0.2707143723964691,
0.17750371992588043,
-1.1851534843444824,
0.26531440019607544,
0.3418336510658264,
0.24123430252075195,
-0.13565778732299805,
0.030795734375715256,
0.4022669494152069,
-0.16387587785720825,
0.27700844407081604,
-0.15416258573532104,
-0.026633141562342644,
-0.25178855657577515,
-0.026769664138555527,
-0.3295249044895172,
-0.3801836669445038,
-0.8087963461875916,
-0.05900038778781891,
-0.6592773795127869,
-0.2986144423484802,
-0.13816167414188385,
0.2790050208568573,
-0.016606494784355164,
-0.3488039970397949,
-0.11000927537679672,
0.5863521099090576,
0.3433229327201843,
-0.5414081811904907,
0.34671029448509216,
0.575706958770752,
-0.2416115254163742,
0.046255260705947876,
0.20837974548339844,
-0.392628937959671,
0.27308189868927,
-0.5286372303962708,
-0.25297173857688904,
-0.6774343848228455,
0.23193183541297913,
0.07793552428483963,
-0.3579213619232178,
0.608066201210022,
-0.2907104194164276,
0.26656728982925415,
0.36830803751945496,
0.6779804825782776,
0.3208751380443573,
-0.12271545082330704,
0.1529369354248047,
-0.27443456649780273,
0.209868386387825,
0.11109575629234314,
-0.03482908010482788,
0.36878424882888794,
0.48502683639526367,
-0.36058101058006287,
-0.0059253680519759655,
-0.31793975830078125,
-0.07599307596683502,
-0.39661264419555664,
-0.4042392373085022,
-0.2425878942012787,
-0.05760627239942551,
0.23548944294452667,
-0.1494244635105133,
0.07181178033351898,
-0.3162083625793457,
0.1389092206954956,
-0.1366402804851532,
-0.009550024755299091,
-0.02535160258412361,
0.006134999915957451,
-0.7428457140922546,
-0.12937825918197632,
-0.4669877588748932,
0.5677581429481506,
-0.1923437863588333,
-0.1703350991010666,
0.6654295921325684,
0.2906317710876465,
-0.04222697764635086,
0.25092414021492004,
0.04574382305145264,
0.3361518979072571,
0.1799147129058838,
-0.16435620188713074,
0.06252072006464005
] |
6,823,860 |
R-wave amplitude change during aerobic exercise in hypertensive adolescents after treatment.
|
Falkner B B, Lowenthal D T DT, Affrime M B MB, Hamstra B B
|
The American journal of cardiology . Vol. 51, No. 3, 1983 Feb
|
This study attempts to determine whether the blunted reduction in R-wave amplitude during progressive aerobic exercise observed in adolescents with systemic hypertension could be altered by pharmacologic therapy to reduce blood pressure. Twenty-nine hypertensive adolescents were randomly assigned to treatment with either a diuretic, hydrochlorothiazide, or a centrally acting agent, clonidine. After 16 weeks of therapy, casual blood pressure was significantly reduced in both groups. Repeat exercise stress testing on therapy demonstrated a significant change in R-wave response. In both treatment groups the change in R-wave amplitude during exercise corresponded with the R-wave response pattern observed in normotensive control subjects. These observations indicate that the altered R-wave amplitude response to exercise observed in young hypertensive subjects is reversible and suggest that the altered R-wave response before treatment is related to a higher vascular resistance.
|
https://pubmed.ncbi.nlm.nih.gov/6823860/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6823860
|
[
-2.6394784450531006,
1.6642735004425049,
-1.8940680027008057,
-2.832749605178833,
0.04278194159269333,
0.3391271233558655,
0.6605194807052612,
-0.7674843072891235,
-1.165382981300354,
0.5854867696762085,
0.01640792191028595,
2.032989025115967,
-0.4903157949447632,
0.5712746381759644,
-0.27042144536972046,
2.4574131965637207,
-0.5659823417663574,
-0.23120097815990448,
1.5735925436019897,
-1.145241141319275,
0.9290087819099426,
-1.086629033088684,
0.5939671397209167,
0.1509375125169754,
0.28089797496795654,
-0.2096453160047531,
-0.6601531505584717,
0.8068496584892273,
0.8662523031234741,
0.4582359492778778,
1.0149081945419312,
0.1153801754117012,
1.282726764678955,
0.3518717885017395,
-0.717002809047699,
-1.307803988456726,
-0.1285352110862732,
0.13977265357971191,
0.03153885528445244,
1.3346866369247437,
1.1955486536026,
0.24742645025253296,
-0.09052355587482452,
-0.4520818591117859,
0.9652528762817383,
0.9152748584747314,
-0.7153623104095459,
0.48125481605529785,
0.9477328658103943,
-0.6201594471931458,
0.14236629009246826,
1.4488199949264526,
-0.4013412594795227,
0.07626400887966156,
2.0968728065490723,
0.775931715965271,
0.19754989445209503,
0.9611043334007263,
0.8914030194282532,
-0.049383264034986496,
0.5734969973564148,
0.4621953070163727,
0.11064610630273819,
1.1117976903915405,
-0.38023582100868225,
-0.3912622034549713,
1.860599160194397,
-0.4301702678203583,
-0.7920577526092529,
0.03368282690644264,
-0.09218636155128479,
0.34811875224113464,
0.3248680830001831,
0.7042898535728455,
1.0518697500228882,
-0.09435319155454636,
0.48592397570610046,
0.44323351979255676,
0.07058364897966385,
-0.2726306617259979,
-1.3513896465301514,
-0.6494179368019104,
-0.882133424282074,
1.3681946992874146,
0.7245165705680847,
-0.2683027386665344,
-0.3462871015071869,
-0.4420257806777954,
0.3215640187263489,
-0.6146310567855835,
-0.49276137351989746,
-0.7549729347229004,
-0.6252915263175964,
0.6399108171463013,
0.4699740707874298,
1.1954480409622192,
-0.42895182967185974,
-0.5058861970901489,
0.16036589443683624,
-0.22320495545864105,
1.2369740009307861,
0.5598851442337036,
-0.1486048400402069,
-0.1081942468881607,
-1.2230465412139893,
-0.4651235044002533,
-0.4694599509239197,
-1.0081597566604614,
-0.3545392155647278,
-0.11962231993675232,
-0.49250972270965576,
-1.5110481977462769,
-0.659544825553894,
-0.8601527214050293,
1.3395020961761475,
-0.2794243097305298,
-0.2772403359413147,
0.5111466646194458,
-0.5264937281608582,
-0.6167317628860474,
-0.04583796486258507,
1.2473399639129639,
-0.14272132515907288,
0.4516109526157379,
-0.5407763123512268,
0.38060280680656433,
-0.5566167831420898,
-1.0601296424865723,
-0.6674994826316833,
-0.09562073647975922,
-0.17646613717079163,
0.09275417774915695,
-0.021428368985652924,
-0.12061621248722076,
-0.9348125457763672,
-0.492622047662735,
-0.1924896389245987,
0.879679799079895,
0.05025209113955498,
-0.20959405601024628,
0.37676993012428284,
0.5129544734954834,
-0.20555809140205383,
0.34744885563850403,
-0.9213218688964844,
-0.925421953201294,
0.23225094377994537,
0.6686744689941406,
0.15226830542087555,
0.31738346815109253,
0.06789746880531311,
0.23053045570850372,
0.38604047894477844,
0.2478378564119339,
-0.4032224118709564,
-0.8686688542366028,
-0.5900163650512695,
-0.41277480125427246,
0.5932319760322571,
-0.6340218782424927,
0.2872612476348877,
-0.3464566469192505,
-0.3604961037635803,
0.1504795402288437,
0.8214098215103149,
-0.5525534152984619,
-0.5176348090171814,
0.3171272575855255,
0.5423848032951355,
0.5823975205421448,
-0.04827721789479256,
0.11083487421274185,
0.15822535753250122,
0.7895333766937256,
-0.9469863176345825,
0.1947866529226303,
0.18929001688957214,
-0.20559890568256378,
0.1362002193927765,
-0.39874693751335144,
-0.0916597843170166,
-0.040952906012535095,
-0.23981894552707672,
0.03509647771716118,
-0.18105140328407288,
-0.5174127221107483,
0.09215643256902695,
0.11016277968883514,
-0.03595149889588356,
-0.41142651438713074,
0.11678671836853027,
0.42915382981300354,
-0.13992935419082642,
-0.3092907667160034,
0.262908399105072,
-0.02035537362098694,
0.05451011285185814,
-0.08883924782276154,
0.19140416383743286,
-0.1241275817155838,
0.161609947681427,
0.6554499864578247,
-0.011042683385312557,
0.39906176924705505,
0.012441580183804035,
0.3416394591331482,
-0.4407491087913513,
-0.15987490117549896,
-0.7452173233032227,
0.7490721344947815,
-0.14293520152568817,
-0.07979591190814972,
-0.4871061444282532,
0.31856486201286316,
0.4486894905567169,
0.38557854294776917,
0.2082606852054596,
-0.10627966374158859,
-0.3269735276699066,
-0.803311288356781,
-0.20133620500564575,
-0.5725794434547424,
0.44339868426322937,
-0.16059134900569916,
-0.5454350113868713,
0.2958022654056549,
0.27513208985328674,
0.09656981378793716,
-0.08434249460697174,
-0.04632760211825371,
-0.41492050886154175,
-0.10170101374387741,
-0.4716189503669739,
-0.09856074303388596,
0.12340205907821655,
0.006175302434712648,
-0.027588268741965294,
-0.19724345207214355,
0.15831400454044342,
-0.10997053980827332,
0.17817255854606628,
-0.060861486941576004,
-0.012175253592431545,
-0.3143327236175537,
0.36120501160621643,
-0.3496650457382202,
-0.21076644957065582,
0.2064284086227417,
0.18683917820453644,
-0.15718522667884827,
-0.20966653525829315,
0.062219422310590744,
-0.1003592312335968,
0.2692606449127197,
0.10621742159128189,
-0.3741587698459625
] |
6,823,861 |
Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol.
|
Roy L L, Mehta J J, Mehta P P
|
The American journal of cardiology . Vol. 51, No. 3, 1983 Feb
|
To evaluate the role of the vasoactive prostaglandins prostacyclin and thromboxane A2 in essential hypertension, the stable metabolites 6-keto-PGF1 alpha and thromboxane B2, respectively, were measured in plasma before and after therapy in 7 patients. During the placebo phase, plasma 6-keto-PGF1 alpha levels were significantly greater than normal. Plasma thromboxane B2 levels were not statistically different from those in normal subjects. After intravenous administration of labetalol to the point of blood pressure reduction, neither plasma 6-keto-PGF1 alpha nor thromboxane B2 values changed. With prolonged oral labetalol therapy and concurrent regulation of blood pressure, a significant decrease in plasma 6-keto-PGF1 alpha levels occurred while thromboxane B2 values remained unaltered. Elevation of plasma 6-keto-PGF1 alpha in untreated hypertensive subjects suggests that enhanced vessel wall prostacyclin synthesis may be a protective mechanism to prevent organ damage. As blood pressure is controlled this increase is no longer needed, and prostacyclin generation returns to normal.
|
https://pubmed.ncbi.nlm.nih.gov/6823861/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6823861
|
[
0.5480651259422302,
1.4055553674697876,
-2.273590326309204,
-3.8625340461730957,
1.6889828443527222,
0.1936234086751938,
0.28171950578689575,
-0.2097756713628769,
-1.6152430772781372,
0.03695656359195709,
0.2768309712409973,
0.06368431448936462,
0.47861921787261963,
-0.7280141711235046,
-0.30227482318878174,
0.26571810245513916,
-0.3765859305858612,
0.23172661662101746,
-0.640929639339447,
-2.1676156520843506,
1.7641974687576294,
-1.415594458580017,
0.2526402771472931,
-0.6118714213371277,
-0.338885098695755,
-1.2058182954788208,
-0.2758180797100067,
0.5020712614059448,
-0.9094476699829102,
1.1102797985076904,
1.0083805322647095,
0.07113192230463028,
1.1332931518554688,
0.29433298110961914,
-0.22549958527088165,
-1.0413830280303955,
1.0152944326400757,
0.13971033692359924,
0.6388159990310669,
-0.3789818584918976,
1.7140464782714844,
0.2743162512779236,
0.8729159832000732,
-0.8650265336036682,
0.6526875495910645,
-0.08178909122943878,
0.15359248220920563,
-1.2697808742523193,
0.8935117125511169,
-0.6590255498886108,
-0.7095365524291992,
0.7807455062866211,
-0.8688068389892578,
0.5505791902542114,
1.8527029752731323,
1.582060694694519,
-0.4786386787891388,
0.7176206707954407,
1.2174549102783203,
-0.29229262471199036,
-0.31560495495796204,
0.1749841421842575,
0.2057265341281891,
0.6740744113922119,
-0.2439844161272049,
-0.7924377918243408,
0.287296861410141,
-0.0721173956990242,
-1.6793895959854126,
1.533857822418213,
-0.560680627822876,
0.41064345836639404,
1.120039701461792,
0.7786760330200195,
1.349730134010315,
1.1804405450820923,
-0.1503169685602188,
0.3278348445892334,
0.6708595752716064,
0.08316148817539215,
-0.36809536814689636,
0.667751669883728,
-0.6783791780471802,
0.17788034677505493,
-0.1567564159631729,
-0.09134175628423691,
-0.16404598951339722,
-1.0670832395553589,
0.3927178680896759,
-0.2331300973892212,
0.754576563835144,
-0.7080667018890381,
-1.5150712728500366,
-0.32195600867271423,
1.1340014934539795,
-0.3856954276561737,
-0.40227994322776794,
0.4711204469203949,
-0.8890479803085327,
-0.18194757401943207,
0.07680246233940125,
-0.14915339648723602,
-0.4268142282962799,
-0.5816306471824646,
0.29577934741973877,
-0.5215724110603333,
0.5622111558914185,
0.28787457942962646,
-0.8082394599914551,
-0.17697644233703613,
-0.7510985732078552,
-1.041094422340393,
-0.08762450516223907,
-0.08759712427854538,
-0.213791161775589,
0.9169985055923462,
-0.791196346282959,
0.29865917563438416,
-0.02806808613240719,
-0.4530709385871887,
-0.7230183482170105,
1.119525671005249,
0.1377003937959671,
0.2824894189834595,
-0.08400682359933853,
0.6551620364189148,
0.5855401158332825,
-0.7078415155410767,
-0.32037970423698425,
-0.5002598166465759,
-0.10012731701135635,
0.20704315602779388,
0.27919426560401917,
0.08943628519773483,
-0.7662370800971985,
-0.49655503034591675,
0.6427626013755798,
0.387982040643692,
-0.1914616823196411,
-1.1791799068450928,
-0.41640031337738037,
0.11906976997852325,
-0.31606918573379517,
-0.519025444984436,
-1.318956971168518,
-0.23031435906887054,
0.2326425164937973,
0.22289831936359406,
-0.04057136923074722,
0.3962864875793457,
-0.4575389623641968,
0.3306770622730255,
0.14010992646217346,
-0.6954500079154968,
-0.18839898705482483,
0.20221690833568573,
-0.300372451543808,
-0.2201119214296341,
-0.12274372577667236,
0.33056366443634033,
-0.1286429762840271,
0.3739471435546875,
-0.3604746162891388,
0.0014022496761754155,
0.7393020391464233,
-0.38872286677360535,
-0.2594905495643616,
0.09115983545780182,
0.13000477850437164,
-0.5467095375061035,
-0.9240567088127136,
0.24163556098937988,
0.5042469501495361,
0.22815808653831482,
-0.7457308769226074,
0.18658596277236938,
0.03984827920794487,
-0.15577086806297302,
-0.23593617975711823,
-0.3058757781982422,
-0.07282053679227829,
0.4927646815776825,
0.039684128016233444,
-0.24115924537181854,
0.1996249258518219,
0.07117713987827301,
-0.07268974930047989,
-0.29297056794166565,
-0.4504002034664154,
0.27982857823371887,
-0.16159309446811676,
0.3423693776130676,
-0.7408419847488403,
-0.257392555475235,
0.6425766944885254,
-0.11896919459104538,
0.1760265827178955,
-0.29065972566604614,
0.991858184337616,
-0.14159713685512543,
-0.16465607285499573,
0.5173494219779968,
0.5319891571998596,
0.6526390314102173,
0.3802165389060974,
0.38858962059020996,
0.3045789897441864,
0.18564249575138092,
0.04883895814418793,
0.20622721314430237,
-0.4091437757015228,
0.32070451974868774,
0.3204665780067444,
0.49348315596580505,
0.42180943489074707,
0.03455118462443352,
-0.26852908730506897,
0.23900289833545685,
-0.08750542253255844,
-0.5117872953414917,
0.07497454434633255,
-0.09610196948051453,
0.35290583968162537,
0.14648067951202393,
-0.136355921626091,
-0.2552804946899414,
0.3392203748226166,
0.19329583644866943,
-0.35785260796546936,
-0.03772207722067833,
-0.6761006712913513,
-0.11608295887708664,
0.05160950869321823,
-0.2402186542749405,
-0.16837579011917114,
-0.031985826790332794,
0.04459461197257042,
0.10666406154632568,
-0.12071719020605087,
0.03883170709013939,
0.21244721114635468,
-0.8023388981819153,
-0.5115678310394287,
0.07256866246461868,
0.5470569133758545,
-0.13170167803764343,
0.14754758775234222,
-0.47042348980903625,
0.590299129486084,
0.021617405116558075,
-0.12887102365493774,
-0.7033640742301941,
-0.15192952752113342,
-0.10412781685590744,
0.05114384740591049,
-0.23104965686798096
] |
6,823,882 |
Modulating effect of Sustagen on plasma glutamate concentration in humans ingesting monosodium L-glutamate.
|
Stegink L D LD, Baker G L GL, Filer L J LJ
|
The American journal of clinical nutrition . Vol. 37, No. 2, 1983 Feb
|
It has been suggested that monosodium L-glutamate (MSG) addition to meals would significantly increase plasma glutamate concentrations compared to values noted after ingestion of protein-bound glutamate. To test this hypothesis, plasma amino acid concentrations were measured in six normal adults ingesting a ready-to-feed liquid meal (Sustagen) containing added MSG at 0, 100, and 150 mg/kg body weight (Latin square design), and compared to plasma values noted after ingestion of 150 mg/kg body weight MSG in water. The mean (+/- SD) peak plasma glutamate concentrations after ingestion of meals providing 0, 100, and 150 mg/kg body weight MSG were 6.64 +/- 1.99, 11.2 +/- 4.89 and 10.8 +/- 3.10 mumol/dl, respectively. Erythrocyte glutamate concentrations were unchanged after each meal. Peak plasma glutamate concentrations after ingestion of meals with added MSG were similar to those noted in normal adults ingesting a similar quantity of protein-bound glutamate. In contrast, ingestion of MSG in water (150 mg/kg body weight) markedly increased the mean (+/- SD) peak plasma glutamate concentration to 71.8 +/- 35.7 mumol/dl. Similarly, the area under the plasma glutamate concentration-time-curve was significantly higher. MSG ingestion with meals results in lower plasma glutamate concentrations than ingestion of equivalent doses in water.
|
https://pubmed.ncbi.nlm.nih.gov/6823882/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6823882
|
[
0.3775039315223694,
-0.2763793170452118,
-2.9857146739959717,
-3.6812283992767334,
1.9049543142318726,
1.8054921627044678,
0.8352714776992798,
-1.0929198265075684,
-1.3900418281555176,
-1.3873759508132935,
0.18791170418262482,
1.098883032798767,
0.20469927787780762,
-1.1399368047714233,
0.2346208095550537,
-1.9840786457061768,
-1.1460442543029785,
0.3613307774066925,
-0.5135510563850403,
-0.8691319823265076,
1.427037239074707,
-0.27654504776000977,
-2.1074295043945312,
-0.26917406916618347,
0.8892003297805786,
-0.6805486679077148,
0.2189561277627945,
1.6206005811691284,
0.31367820501327515,
1.662488579750061,
1.5613317489624023,
-0.18936841189861298,
1.0504941940307617,
-1.0126981735229492,
1.9435358047485352,
-0.3177037835121155,
1.2211477756500244,
1.0306462049484253,
0.19003377854824066,
-0.6333843469619751,
0.556445837020874,
1.0180484056472778,
0.954390823841095,
0.06683310866355896,
0.583134114742279,
0.7653094530105591,
0.4067608416080475,
-1.0865627527236938,
-0.39446476101875305,
0.4658588767051697,
0.31920483708381653,
-0.08659380674362183,
-1.1196057796478271,
-0.4347444474697113,
1.4615752696990967,
0.03697999566793442,
1.0998786687850952,
-1.513980746269226,
1.5845942497253418,
0.7519369721412659,
-0.43397584557533264,
0.6413770318031311,
-0.09350191056728363,
0.25455957651138306,
0.025084005668759346,
-1.4874341487884521,
0.02159208618104458,
0.7896578907966614,
-0.24425669014453888,
0.2854888141155243,
-1.6581535339355469,
-0.22957605123519897,
0.6098043918609619,
0.14182019233703613,
0.8767187595367432,
0.9484013915061951,
0.7286590933799744,
0.40782099962234497,
0.9616398215293884,
0.866744339466095,
-0.03936963900923729,
0.09362682700157166,
-0.4612947404384613,
-0.155340313911438,
0.2609326243400574,
0.8907997608184814,
-1.1662834882736206,
-0.05748959258198738,
0.7035635709762573,
-0.11423753201961517,
0.43275052309036255,
-1.6530934572219849,
-2.4967644214630127,
-0.5477667450904846,
-0.3234741985797882,
-0.4951493442058563,
0.8355797529220581,
-0.054854974150657654,
0.011326447129249573,
-0.3619534373283386,
0.3658076822757721,
-0.09320461750030518,
-1.0807048082351685,
0.048717427998781204,
0.2781416177749634,
-0.420205682516098,
-0.8551099896430969,
0.2386987954378128,
-1.4700714349746704,
0.09875520318746567,
-0.5247458219528198,
-0.4395124912261963,
-0.22344930469989777,
-0.4916122853755951,
0.45981788635253906,
-0.08687227964401245,
-0.7775123715400696,
0.3035901188850403,
-0.0694638043642044,
-0.9535484910011292,
0.7321099042892456,
0.8703773617744446,
-0.3440302610397339,
-0.3635212182998657,
-0.1904985010623932,
-0.4650682210922241,
0.4046523869037628,
-0.9022782444953918,
0.12296237796545029,
-0.3077147305011749,
-0.3407970666885376,
0.9064654111862183,
0.0858989730477333,
-0.164569690823555,
-0.15173496305942535,
0.3134484887123108,
-0.34225699305534363,
0.6513901352882385,
0.27257925271987915,
-0.8612382411956787,
-0.913575291633606,
-0.14679425954818726,
-0.7316316962242126,
0.55230313539505,
-1.339867353439331,
0.525684654712677,
-0.4719964861869812,
0.2022920399904251,
-0.7521308064460754,
-0.15743251144886017,
0.34411942958831787,
0.4493137300014496,
0.18072567880153656,
-0.24962879717350006,
-0.37793081998825073,
0.0864667072892189,
0.4319930672645569,
0.3656351566314697,
0.016957733780145645,
0.18747900426387787,
-0.10573428124189377,
-0.11243892461061478,
-0.11752323806285858,
-0.2886039912700653,
0.5175427794456482,
0.3988332748413086,
0.06139563024044037,
-0.38557469844818115,
-0.18946970999240875,
-0.358803927898407,
-0.03661264106631279,
-0.07757661491632462,
0.41287627816200256,
0.7952002882957458,
0.13826188445091248,
0.017869731411337852,
0.014433115720748901,
0.16170671582221985,
0.2859037220478058,
-0.11781400442123413,
0.22249916195869446,
-0.13265496492385864,
0.49125543236732483,
-0.6430637240409851,
0.0758812353014946,
-0.027602633461356163,
0.05395720526576042,
-0.18423230946063995,
0.17644119262695312,
0.10639111697673798,
0.2661714553833008,
0.5381615161895752,
-0.48539549112319946,
-0.3271365761756897,
0.29430091381073,
0.013736635446548462,
0.008123585022985935,
-0.47771337628364563,
0.22579623758792877,
-0.5136535167694092,
0.20326921343803406,
0.6917330026626587,
-0.3061411678791046,
0.42793866991996765,
-0.08256848156452179,
-0.42292046546936035,
0.09150919318199158,
0.44770684838294983,
-0.3697885274887085,
0.2916219234466553,
-0.02125953510403633,
0.2631450295448303,
0.225456103682518,
-0.05572785809636116,
0.32106584310531616,
0.25143563747406006,
0.02196921966969967,
0.7234354615211487,
-0.25239333510398865,
0.3249529302120209,
-0.3090875446796417,
-0.18717633187770844,
-0.10412045568227768,
-0.08984380215406418,
-0.24384091794490814,
-0.45151183009147644,
-0.27807867527008057,
0.11681821197271347,
-0.37889838218688965,
-0.45557114481925964,
-0.35618263483047485,
-0.32643985748291016,
-0.1644003987312317,
-0.29539698362350464,
0.024447329342365265,
-0.29778820276260376,
-0.14233845472335815,
-0.34331774711608887,
-0.20269936323165894,
-0.030914276838302612,
0.2731378674507141,
-0.4983710050582886,
-0.11997001618146896,
0.26629817485809326,
0.4645986557006836,
-0.2771105170249939,
-0.22755181789398193,
0.4703759253025055,
0.31402912735939026,
-0.7156803011894226,
0.1484520584344864,
0.25253933668136597,
-0.253454327583313,
0.338083416223526,
0.011947590857744217,
-0.1355319619178772
] |
6,823,889 |
Iron absorption from some Asian meals containing contamination iron.
|
Hallberg L L, Björn-Rasmussen E E, Rossander L L, Suwanik R R, Pleehachinda R R, Tuntawiroon M M
|
The American journal of clinical nutrition . Vol. 37, No. 2, 1983 Feb
|
Iron absorption was measured from 12 Asian meals using the extrinsic tag method. Up to 50% of the nonheme iron in the meals did not exchange with the added inorganic radioiron tracer. The extent of isotopic exchange, the native iron and the "contamination" iron was measured using a recently developed in vitro method. The results imply that in measurements of iron absorption from meals, especially in developing countries, it is essential to consider the presence of contamination iron and its limited bioavailability.
|
https://pubmed.ncbi.nlm.nih.gov/6823889/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6823889
|
[
1.4033520221710205,
2.827683210372925,
-2.948709487915039,
-2.754498243331909,
0.3010094463825226,
0.6475568413734436,
0.45122507214546204,
-0.8491457104682922,
-0.5625486373901367,
-0.10789915174245834,
-0.2723628580570221,
2.0450189113616943,
0.20904427766799927,
-0.7811537981033325,
1.95747971534729,
0.2716907262802124,
-0.5561705827713013,
-0.5340542197227478,
1.6660430431365967,
-1.516762375831604,
-0.25866058468818665,
-0.642370343208313,
0.03925462067127228,
0.7436768412590027,
1.1400525569915771,
0.40619805455207825,
0.22224611043930054,
-0.3490331768989563,
0.10760187357664108,
0.6961510181427002,
1.339468240737915,
0.9404128789901733,
-0.21474988758563995,
-0.6808117628097534,
0.4609779119491577,
0.22429093718528748,
3.071664333343506,
1.497236967086792,
-1.841698169708252,
-0.10556346923112869,
0.32510921359062195,
0.17897996306419373,
-0.8055549263954163,
-0.14270883798599243,
0.4997742176055908,
-1.6549441814422607,
1.0850963592529297,
-1.0093547105789185,
-1.2134209871292114,
1.5426985025405884,
0.21894030272960663,
0.13814446330070496,
0.060916367918252945,
-0.05230918154120445,
2.0760250091552734,
0.6835336685180664,
0.6372019648551941,
-0.20922806859016418,
0.350835382938385,
0.7016763687133789,
0.0725034698843956,
0.08821338415145874,
-1.1119359731674194,
0.9649412631988525,
-1.133543848991394,
-0.48212504386901855,
0.29322147369384766,
0.18137593567371368,
-0.5575616955757141,
1.1619019508361816,
0.7501810193061829,
-0.8628053665161133,
-0.60611891746521,
0.08765362948179245,
0.33967652916908264,
-0.04291161894798279,
-0.6040905714035034,
-0.07642674446105957,
-0.9095232486724854,
1.523115873336792,
0.31178346276283264,
-0.4433134198188782,
0.2012706696987152,
0.8177486658096313,
0.3498130738735199,
0.33894914388656616,
-0.13259142637252808,
-0.5167324542999268,
0.17575399577617645,
-0.03882473707199097,
-0.21367016434669495,
-0.7796407341957092,
-1.1509114503860474,
0.2841176986694336,
-0.5655093789100647,
0.17215895652770996,
-0.027727719396352768,
-0.0341561958193779,
-0.5119395852088928,
-0.08158722519874573,
0.8144524097442627,
0.11255019158124924,
-0.19542254507541656,
0.04580060765147209,
-0.10314436256885529,
-0.26129111647605896,
-1.0897397994995117,
0.344767689704895,
-0.1012447252869606,
-0.21108867228031158,
-0.6309178471565247,
-0.5411659479141235,
1.1843385696411133,
-0.597827136516571,
-0.3527179956436157,
0.04758981242775917,
-1.0843098163604736,
0.2678174674510956,
0.16141648590564728,
0.19782815873622894,
0.046163659542798996,
0.08413463085889816,
0.08705294132232666,
0.8905575275421143,
-0.5267231464385986,
0.8134281635284424,
0.723437488079071,
-0.9202024340629578,
-1.062988519668579,
-1.1160807609558105,
-0.8479011058807373,
0.6900874376296997,
0.17898452281951904,
-0.35131770372390747,
-0.07307183742523193,
0.8125967383384705,
0.26294368505477905,
0.4275887906551361,
-0.200871080160141,
0.2949698567390442,
-1.0673538446426392,
0.6141114234924316,
-0.3475930094718933,
0.7092958092689514,
-0.6591988205909729,
-0.09808114171028137,
-0.48569217324256897,
-0.5843011140823364,
0.059496548026800156,
-0.3672267496585846,
0.0949188843369484,
0.2760969400405884,
-0.398360937833786,
0.3322288393974304,
0.16941584646701813,
-0.33139970898628235,
0.445171058177948,
0.025143368169665337,
-0.3150954842567444,
0.24196290969848633,
-0.13149084150791168,
0.194585382938385,
-0.3656955063343048,
-0.38993772864341736,
0.25717273354530334,
-0.42287683486938477,
-0.12411541491746902,
-0.7753522396087646,
1.0421557426452637,
-0.1624743640422821,
0.3536582589149475,
0.6742139458656311,
-0.16322524845600128,
0.16743777692317963,
0.2395193874835968,
-0.06714064627885818,
-0.33863216638565063,
0.5392856597900391,
0.2677716314792633,
-0.0826614499092102,
0.06069698929786682,
-0.35009169578552246,
0.11418519914150238,
-0.19514670968055725,
-0.2410438358783722,
-0.7236660718917847,
-0.04786930978298187,
0.32138097286224365,
0.3912869095802307,
0.20449337363243103,
0.12635451555252075,
0.3606142997741699,
-0.29444804787635803,
-0.13727430999279022,
0.43941789865493774,
0.36944180727005005,
-0.23249664902687073,
-0.05729757621884346,
-0.44108709692955017,
0.04191360995173454,
0.2823992371559143,
0.07027434557676315,
0.02884594537317753,
-0.7342981696128845,
-0.11360358446836472,
-0.2550945580005646,
0.5172460079193115,
0.49985483288764954,
-0.15470023453235626,
-0.09781385958194733,
0.5061594247817993,
0.3009783625602722,
0.3390088677406311,
-0.24583899974822998,
-0.16837343573570251,
-0.243405282497406,
0.12819087505340576,
0.8619205951690674,
-0.46506285667419434,
0.04931863024830818,
0.08611420542001724,
-0.4986281394958496,
-0.33146241307258606,
0.3486933410167694,
0.4156416356563568,
-0.4259781837463379,
-0.6427719593048096,
0.21430186927318573,
0.1683366298675537,
0.28618672490119934,
-0.09335712343454361,
-0.004381138831377029,
-0.0008527725003659725,
-0.36878591775894165,
0.009742394089698792,
-0.18004530668258667,
0.2480858415365219,
-0.12443986535072327,
0.053938549011945724,
0.42515769600868225,
-0.08336307108402252,
-0.1931667923927307,
-0.07366490364074707,
-0.2057996243238449,
-0.08029747754335403,
-0.14793609082698822,
0.07040885090827942,
0.3579350709915161,
0.1843295693397522,
-0.10422742366790771,
0.21328403055667877,
-0.30471572279930115,
-0.2557329833507538,
0.16301555931568146,
0.043363649398088455,
0.07829391956329346
] |
6,823,925 |
Five v ten days' therapy with furazolidone for giardiasis.
|
Murphy T V TV, Nelson J D JD
|
American journal of diseases of children (1960) . Vol. 137, No. 3, 1983 Mar
|
In previous uncontrolled studies it has been reported that five days' treatment with furazolidone is effective for giardiasis. Efficacy of five v ten days of treatment was evaluated in a prospective, randomized study of 22 children with giardiasis. Eleven of 12 patients (92%) treated for ten days were cured based on clinical and parasitological response; one patient did not tolerate furazolidone and was treated with quinacrine hydrochloride. Only two of ten patients (20%) treated with a five-day regimen were cured. Of the other eight patients, five had prompt relapse of diarrhea after furazolidone treatment was stopped, diarrhea persisted in two, and diarrhea diminished but Giardia persisted in one. Six of eight patients in whom the five-day regimen failed were re-treated with furazolidone for ten days, and five patients were cured. Therapy with furazolidone for less than seven to ten days cannot be recommended for children with giardiasis.
|
https://pubmed.ncbi.nlm.nih.gov/6823925/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6823925
|
[
0.08676515519618988,
-0.5730106830596924,
-0.8515365719795227,
0.7525408267974854,
-0.5600343942642212,
-0.24798335134983063,
1.152881145477295,
0.9901456236839294,
-0.5714066624641418,
-0.16761864721775055,
0.4375443160533905,
2.2046566009521484,
-1.8345547914505005,
0.8392650485038757,
-0.25115665793418884,
-1.021003007888794,
-0.2174016833305359,
-0.22460809350013733,
2.1175014972686768,
-2.3501782417297363,
1.3291112184524536,
-0.672239363193512,
-0.7663516402244568,
0.6629774570465088,
0.10941421240568161,
-1.2799620628356934,
-0.8744776844978333,
0.7300499081611633,
0.8228890895843506,
2.071411371231079,
-0.8118494749069214,
-0.5208455920219421,
-0.5230004787445068,
-0.567639172077179,
0.44304418563842773,
0.25866517424583435,
0.12970755994319916,
0.16952043771743774,
-1.0162413120269775,
0.6524683237075806,
-0.2095639556646347,
0.2363346815109253,
0.025021851062774658,
-0.4835609495639801,
2.1000070571899414,
0.4701720178127289,
0.8969683647155762,
0.04478630796074867,
0.14439862966537476,
0.012037009000778198,
-1.065298080444336,
1.4098011255264282,
-0.06733740121126175,
-0.37148067355155945,
0.8358815312385559,
0.3116424083709717,
-0.42352765798568726,
0.8784193992614746,
-0.22680307924747467,
-0.6912400722503662,
0.7653854489326477,
2.239485740661621,
-1.0238564014434814,
-0.04296063631772995,
-0.2141430377960205,
-0.8645633459091187,
-0.048818089067935944,
0.13243161141872406,
-0.4213934540748596,
0.543971598148346,
-0.38902828097343445,
-0.11906751245260239,
-0.2872872054576874,
0.7194170355796814,
1.0733022689819336,
-0.6912531852722168,
-0.19387102127075195,
0.8359916806221008,
-0.07717383652925491,
-0.5621627569198608,
-1.0622295141220093,
0.6197677850723267,
0.14890863001346588,
0.38885951042175293,
0.08997855335474014,
-0.23665620386600494,
-0.6272516250610352,
-0.7422373294830322,
-0.10727673023939133,
-1.1663501262664795,
-0.41848474740982056,
-0.5923562049865723,
-0.39383289217948914,
0.015923066064715385,
-0.8309428691864014,
0.23271527886390686,
-0.01646771840751171,
-0.5293670892715454,
-0.595136284828186,
0.9946151375770569,
0.23087701201438904,
-1.113713026046753,
0.09002511203289032,
0.5808016061782837,
-1.432157039642334,
-0.6149263381958008,
0.3187824785709381,
-1.1020935773849487,
-0.06628406792879105,
-0.6451924443244934,
0.27323898673057556,
-0.30937460064888,
0.6276524066925049,
-0.1026085689663887,
0.2054276019334793,
-0.060015127062797546,
0.8114318251609802,
-0.4084464907646179,
-0.3601674735546112,
0.4919884204864502,
0.8439952731132507,
0.7663410305976868,
0.19664283096790314,
-0.4697810113430023,
-0.33738258481025696,
-0.760208785533905,
-0.10127731412649155,
0.3925260901451111,
-0.9748768210411072,
-0.9017353653907776,
-1.1172070503234863,
0.4361768960952759,
-0.44235023856163025,
-0.21675661206245422,
-1.1180624961853027,
-0.914990246295929,
0.13839620351791382,
1.2786967754364014,
0.3073984682559967,
-0.04801749065518379,
-0.11111203581094742,
0.8336196541786194,
0.016820291057229042,
0.652070939540863,
-1.2451958656311035,
-0.6655667424201965,
-0.39984452724456787,
-0.07456022500991821,
-1.1785752773284912,
0.2885682284832001,
0.2576149106025696,
-0.18125323951244354,
-0.6302730441093445,
0.022692540660500526,
-0.5574862360954285,
0.25423893332481384,
0.954605758190155,
-0.4694805145263672,
0.3972984552383423,
-0.21541258692741394,
-0.030051734298467636,
-0.8105729222297668,
0.7086777091026306,
-0.8970608711242676,
0.7158410549163818,
-0.15149161219596863,
-0.4891913831233978,
0.06867766380310059,
0.20650459825992584,
0.8031822443008423,
-1.0157564878463745,
0.5182475447654724,
-0.3632221519947052,
0.37940478324890137,
-0.31847015023231506,
-0.19996564090251923,
0.8310425877571106,
-0.2697908282279968,
0.29211872816085815,
-0.26436200737953186,
-0.5864338278770447,
-0.6901379227638245,
-0.6881139278411865,
0.20479926466941833,
-0.15351668000221252,
0.00031345465686172247,
-0.5886071920394897,
0.43071871995925903,
0.09354414790868759,
1.0791511535644531,
0.9173809289932251,
-0.48410868644714355,
0.1740366816520691,
0.16826887428760529,
0.3619043231010437,
-0.13325338065624237,
0.30964258313179016,
0.306143581867218,
0.6041070818901062,
0.18263429403305054,
-0.08816292136907578,
0.446200430393219,
-0.23023641109466553,
0.0455084890127182,
0.13014432787895203,
0.03200027719140053,
0.16620635986328125,
-0.586016833782196,
-0.1262468695640564,
0.35615670680999756,
0.1962217092514038,
0.0061120870523154736,
-0.1114991158246994,
-0.17002400755882263,
-0.33350512385368347,
0.49025747179985046,
0.49569207429885864,
-0.3346223831176758,
-0.07370583713054657,
-0.007072886452078819,
-0.3827365040779114,
-0.27834880352020264,
0.514089822769165,
-0.03209584951400757,
0.19412943720817566,
-0.22141237556934357,
-0.18941570818424225,
0.4168775677680969,
-0.13360680639743805,
-0.2854180932044983,
-0.06377536803483963,
-0.48168838024139404,
0.2669389247894287,
0.18191474676132202,
-0.003811139613389969,
0.26169273257255554,
0.04450339823961258,
0.14717888832092285,
0.05521409213542938,
-0.3321104347705841,
-0.3165699541568756,
-0.9435124397277832,
-0.2122558057308197,
-0.42786362767219543,
0.06539583206176758,
0.06046575307846069,
-0.19058862328529358,
0.12075918912887573,
0.11663336306810379,
0.44503095746040344,
-0.595329999923706,
-0.3163999021053314,
-0.07329589128494263,
0.10531371086835861,
0.5306421518325806,
-0.2416238635778427
] |
6,824,134 |
Intraoperative autotransfusion during abdominal aortic reconstruction.
|
O'Hara P J PJ, Hertzer N R NR, Santilli P H PH, Beven E G EG
|
American journal of surgery . Vol. 145, No. 2, 1983 Feb
|
Intraoperative autotransfusion by a continuous-flow centrifuge system was used during more than 300 abdominal aortic reconstructions at the Cleveland Clinic since May 1979. Fifty consecutive patients undergoing such operations were studied prospectively. Volumes of blood lost, salvaged, and transfused during each operation were tabulated. Autologous autotransfused blood was compared with homologous bank blood with respect to oxygen-carrying capacity, coagulation factors, microaggregate levels, red cell mass, pH, and free hemoglobin concentration. Chromium-51 red cell survival studies were performed in autotransfused blood in random patients and in control subjects. Renal, hepatic, and coagulation functions were determined during the first postoperative week. Each patient received a mean volume of 1,203 ml of autotransfused blood and 1,682 ml of bank blood to replace a mean operative blood loss of 2,386 ml. Red blood cell survival of both salvaged autologous and unshed autologous blood in the control group was nearly identical. Salvaged blood had superior oxygen-carrying capacity, a lower microaggregate level, and better buffering capacity than bank blood. Although transient elevations in liver function values and free hemoglobin levels were noted, no clinically important aberration of coagulation, hepatic, or renal function was demonstrated.
|
https://pubmed.ncbi.nlm.nih.gov/6824134/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6824134
|
[
-0.16475917398929596,
2.2370784282684326,
-1.1137893199920654,
-1.7331323623657227,
2.3077430725097656,
1.7018216848373413,
0.46906334161758423,
-0.620242714881897,
-2.546546459197998,
0.6329265236854553,
0.7018575668334961,
0.9674327373504639,
0.7811765074729919,
1.217751383781433,
0.018462011590600014,
0.37272095680236816,
-1.5365182161331177,
-0.23764261603355408,
0.2703770101070404,
-1.1460579633712769,
0.5458245277404785,
-1.1575566530227661,
-0.19431008398532867,
0.4050666093826294,
1.0842562913894653,
-1.0004048347473145,
1.1913262605667114,
-0.5755654573440552,
-0.03372552618384361,
1.1156411170959473,
0.5308047533035278,
-0.4274536669254303,
-0.2817990481853485,
0.6311208009719849,
0.7681377530097961,
-1.226503849029541,
1.8218389749526978,
0.131612166762352,
-0.5069020986557007,
-0.7192752957344055,
1.112517237663269,
1.2768568992614746,
0.4634378254413605,
-0.49760472774505615,
0.9145504832267761,
0.3043268918991089,
1.2119581699371338,
0.5659819841384888,
0.704698383808136,
0.7183135151863098,
-0.6116604208946228,
-0.03988141566514969,
-1.2320855855941772,
-0.20630325376987457,
0.2745313346385956,
1.6627469062805176,
0.37264108657836914,
-0.0078065525740385056,
0.9679339528083801,
-0.4063965678215027,
0.3990178108215332,
-0.17087005078792572,
0.08217289298772812,
-0.1335625946521759,
-1.673479437828064,
-0.6392852663993835,
0.8447058796882629,
-0.3573872745037079,
-1.0183920860290527,
0.4977685809135437,
-0.9092289805412292,
0.2233651876449585,
0.7515537738800049,
0.574368417263031,
1.1899821758270264,
0.9246174693107605,
-0.3831734359264374,
1.0046818256378174,
0.12024132907390594,
-0.09123692661523819,
-0.8778987526893616,
0.4250834286212921,
-0.8477832078933716,
0.7479228377342224,
-0.41191592812538147,
0.11586114019155502,
-0.2932535707950592,
-0.21163499355316162,
0.4138137102127075,
-0.8308770060539246,
0.7872358560562134,
0.2586406171321869,
-1.7499747276306152,
0.2612874209880829,
-0.7566995620727539,
-0.30084794759750366,
-0.2525791525840759,
0.038483619689941406,
-0.44616708159446716,
0.019541246816515923,
-0.5888695120811462,
-0.28884565830230713,
0.003961415495723486,
-0.6943591833114624,
0.550091028213501,
-0.8350069522857666,
1.0058215856552124,
-0.39847487211227417,
-0.6788985133171082,
-0.168989360332489,
-0.39849236607551575,
-1.1221867799758911,
-0.07375992834568024,
0.28344401717185974,
-0.9055315256118774,
0.5929582715034485,
0.7689445614814758,
-0.05659577250480652,
0.5796485543251038,
-0.15992341935634613,
-0.6685909628868103,
1.3040543794631958,
0.2082517296075821,
0.026734521612524986,
0.17687401175498962,
0.5738415122032166,
0.2314348816871643,
-0.1911333203315735,
0.0054450142197310925,
-0.24572725594043732,
-0.5169004797935486,
0.1846516728401184,
-0.13974589109420776,
-0.12318945676088333,
-0.33083054423332214,
0.03661734238266945,
0.35601747035980225,
0.6391881704330444,
0.17168574035167694,
-0.39647364616394043,
-0.020649166777729988,
-0.7854408621788025,
-0.59935462474823,
-0.06952032446861267,
-1.101446270942688,
-0.2491552233695984,
-0.4345485270023346,
1.0557711124420166,
-0.2208625227212906,
-0.06854575127363205,
-0.227903813123703,
-0.478562593460083,
0.7930567264556885,
-0.1509721726179123,
-0.17920127511024475,
-0.0850762203335762,
0.17263944447040558,
0.42430365085601807,
-0.17726358771324158,
0.09832566231489182,
-0.6391359567642212,
0.12977063655853271,
0.07080292701721191,
-0.17112037539482117,
0.4835855960845947,
-0.7023371458053589,
-0.021732445806264877,
-0.1770397424697876,
0.555898129940033,
0.2886906564235687,
-0.8805534839630127,
0.36881208419799805,
0.040388770401477814,
0.4639907479286194,
-0.6479161977767944,
-0.45646682381629944,
0.13582569360733032,
0.3557831346988678,
0.41086941957473755,
0.05132988840341568,
-0.45644983649253845,
-0.13386234641075134,
0.519641101360321,
-0.3615974187850952,
-0.023467523977160454,
-0.10461077094078064,
-0.5549089908599854,
-0.09160501509904861,
0.030648795887827873,
0.11514757573604584,
0.06279809027910233,
-0.07286655902862549,
-0.10353463143110275,
0.23297551274299622,
-0.08406686037778854,
-0.1746809035539627,
-0.1705697625875473,
0.20332591235637665,
0.5117053985595703,
-0.14936232566833496,
0.49647337198257446,
0.45392173528671265,
0.14480675756931305,
0.5165703296661377,
0.22366607189178467,
-0.3335118591785431,
0.40164119005203247,
0.16471035778522491,
-0.12557834386825562,
0.3423612415790558,
0.10207541286945343,
-0.20068611204624176,
0.40985703468322754,
0.26767104864120483,
0.43081867694854736,
-0.07722371816635132,
0.5314016938209534,
0.12862998247146606,
-0.27542737126350403,
-0.08413486927747726,
0.5898611545562744,
-0.14883729815483093,
-0.12110783904790878,
-0.023916130885481834,
-0.10503693670034409,
0.10951071232557297,
0.07409249246120453,
0.21445739269256592,
-0.11726601421833038,
-0.11792434006929398,
-0.0905052199959755,
-0.13764595985412598,
-0.44012919068336487,
-0.24671350419521332,
0.2420704960823059,
0.21751517057418823,
0.07649751007556915,
0.3143494427204132,
-0.1459907442331314,
0.3680550158023834,
-0.46181440353393555,
-0.5393607020378113,
-0.19261308014392853,
-0.20740744471549988,
0.22333423793315887,
-0.0911472961306572,
0.0513751395046711,
-0.36387160420417786,
0.11446502804756165,
-0.09052125364542007,
0.2891087234020233,
0.0003699134394992143,
-0.043915919959545135,
-0.28559741377830505,
-0.0943792462348938,
0.12150036543607712
] |
6,824,149 |
Total intravenous anaesthesia with etomidate-fentanyl. Use in general and gynaecological surgery.
|
Jones D D, Laurence A S AS, Thornton J A JA
|
Anaesthesia . Vol. 38, No. 1, 1983 Jan
|
A total intravenous anaesthetic technique using etomidate, fentanyl and neuromuscular blocking drugs with artificial ventilation of the lungs has been used in 90 patients undergoing elective general and gynaecological surgery. A two-step schedule was used, based on a pharmacokinetic model for rapidly eliminated, intravenously administered drugs. Etomidate 100 micrograms/kg/minute with fentanyl 1 microgram/kg/minute were given for 10 minutes, followed by a maintenance dose at a rate of one-tenth this amount. Concurrent evaluation of the technique led to variations in the adjuvant drugs used (atropine, droperidol and neuromuscular blocking agent). The basic dose schedule provided adequate surgical anaesthesia for 76% of patients (although dose adjustments were used in the remainder), with recovery times of 10 minutes or less in 57% of patients. No further opiate analgesia was needed in 40% of patients postoperatively. Those patients given atropine intravenously prior to induction had a significantly lower incidence of nausea and vomiting postoperatively.
|
https://pubmed.ncbi.nlm.nih.gov/6824149/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6824149
|
[
-0.8613113760948181,
1.62290358543396,
-2.1003122329711914,
-2.9059743881225586,
0.07206816226243973,
0.331539511680603,
0.26137781143188477,
0.2206398993730545,
-1.3486993312835693,
0.3760205805301666,
-0.16560105979442596,
1.8726261854171753,
0.06030195578932762,
0.9704328775405884,
0.9275501370429993,
-0.32977721095085144,
-0.06778474897146225,
-0.25407931208610535,
0.12861977517604828,
-2.226407527923584,
-0.26303181052207947,
-0.8612762689590454,
-1.3412845134735107,
0.638619065284729,
0.9244591593742371,
-0.4043370187282562,
0.5214642882347107,
1.1335580348968506,
0.9499105215072632,
1.1659342050552368,
-0.22571124136447906,
-1.421581745147705,
-0.04525231942534447,
1.3457660675048828,
-0.15889732539653778,
0.418747216463089,
0.8794365525245667,
0.03394651785492897,
-1.2480353116989136,
0.3372543454170227,
0.9902026653289795,
0.3894447982311249,
0.020126061514019966,
-0.9155983328819275,
1.4741144180297852,
0.5528596639633179,
0.1039898544549942,
0.6158066391944885,
1.6029540300369263,
-0.08188389986753464,
-0.6084328889846802,
0.9236949682235718,
-0.8679326772689819,
-1.0085726976394653,
1.5064738988876343,
0.2791058123111725,
0.6875380873680115,
-0.3252848982810974,
0.590205729007721,
-0.5877426266670227,
0.29142603278160095,
0.3792908191680908,
0.3782726228237152,
0.4309333264827728,
-0.6785426139831543,
-0.26709848642349243,
1.0349546670913696,
0.6976183652877808,
0.03617270290851593,
0.792106568813324,
-0.696722686290741,
0.7780981063842773,
-0.5126445293426514,
-0.04701609164476395,
0.6676508188247681,
0.9074045419692993,
-0.07953406125307083,
0.5242003202438354,
0.7815937995910645,
0.17481879889965057,
-0.8144506216049194,
-0.5690473914146423,
-0.04905804619193077,
0.11737746745347977,
-0.7666340470314026,
0.656522810459137,
-0.6152670979499817,
0.19297397136688232,
0.26556462049484253,
-0.6289753317832947,
-0.15198096632957458,
-0.652255654335022,
-1.8273729085922241,
-0.19758237898349762,
-0.9647249579429626,
0.6843772530555725,
-0.021391253918409348,
-0.29732099175453186,
-1.109260082244873,
-0.14641256630420685,
0.016217980533838272,
0.3826252520084381,
-0.06692596524953842,
-0.13531413674354553,
-0.6505133509635925,
-0.16322852671146393,
-0.5182062387466431,
-0.7355259656906128,
-0.9521694183349609,
-1.3618426322937012,
0.6422333121299744,
-0.39039862155914307,
0.4065270721912384,
-0.380692720413208,
0.34668266773223877,
0.661545991897583,
-0.593353807926178,
-0.21360360085964203,
0.3742591142654419,
-0.04677563160657883,
0.4285525679588318,
0.4095552861690521,
-0.7989163994789124,
-0.41068825125694275,
-0.5781750679016113,
-0.572899341583252,
0.04417283460497856,
0.6481045484542847,
-0.18816570937633514,
-0.4301469922065735,
-0.9336399435997009,
1.0328049659729004,
0.0018406180897727609,
-0.44126856327056885,
-1.6601879596710205,
-1.0251318216323853,
0.49291637539863586,
1.2350984811782837,
0.06640653312206268,
-0.2764807343482971,
-0.09856723994016647,
0.7386641502380371,
-0.481720894575119,
-0.298578143119812,
-0.8871793150901794,
-0.24294781684875488,
-1.2816214561462402,
0.5536379218101501,
-0.41261374950408936,
0.0577683188021183,
-0.0037851575762033463,
-0.1858864277601242,
-0.06143077090382576,
-0.48955824971199036,
0.2652571201324463,
0.17870847880840302,
0.6211830973625183,
0.555340051651001,
0.2055371105670929,
-0.3778897821903229,
-0.3567154109477997,
-0.46349814534187317,
-0.1387719362974167,
-0.7551972270011902,
-0.20459474623203278,
-0.25596243143081665,
-0.2682049870491028,
-0.02005564235150814,
0.3297300338745117,
0.4681256413459778,
-0.5397157669067383,
0.42624589800834656,
0.05329214408993721,
0.34604424238204956,
-0.4557667672634125,
-0.2410425990819931,
0.15777219831943512,
-0.01508821826428175,
0.5833509564399719,
0.5604974627494812,
-0.035426415503025055,
-0.14148351550102234,
0.2899671792984009,
-0.34728989005088806,
-0.27987343072891235,
-0.5042012333869934,
0.42134711146354675,
-0.2378559410572052,
0.2767549455165863,
0.2841137647628784,
0.3899343013763428,
-0.16092155873775482,
-0.31493258476257324,
0.20823143422603607,
0.3045653998851776,
-0.221079021692276,
-0.19163671135902405,
0.020326487720012665,
0.36742255091667175,
0.1695445030927658,
0.36043161153793335,
0.14329059422016144,
-0.4023520052433014,
0.5294011831283569,
0.20665255188941956,
-0.4879150092601776,
-0.18852704763412476,
0.17470380663871765,
-0.14722415804862976,
0.24142681062221527,
0.38205447793006897,
-0.28483033180236816,
-0.329861581325531,
0.30792251229286194,
0.18356698751449585,
-0.48886778950691223,
0.16139788925647736,
0.13018006086349487,
-0.13966131210327148,
-0.09173550456762314,
-0.08967935293912888,
-0.11599200963973999,
-0.12708468735218048,
0.4243185818195343,
-0.06657195836305618,
-0.04288661479949951,
0.2617901861667633,
0.09036174416542053,
-0.1591043770313263,
-0.415047287940979,
-0.04394173249602318,
0.46320316195487976,
0.2389385849237442,
0.1787228286266327,
0.3262386918067932,
-0.12192035466432571,
-0.025290092453360558,
0.11912909150123596,
-0.05256960168480873,
0.08263085782527924,
0.03696481138467789,
-0.7642838358879089,
-0.04839017987251282,
0.021028991788625717,
0.4820919632911682,
0.19173181056976318,
0.3813314437866211,
-0.04555940628051758,
-0.2230912744998932,
-0.05605960637331009,
0.35411393642425537,
-0.16807176172733307,
0.12150502949953079,
0.5262851119041443,
-0.3021576702594757,
-0.05796040594577789
] |
6,824,189 |
Placebo controlled double blind study with pentoxifylline of walking performance in patients with intermittent claudication.
|
Di Perri T T, Guerrini M M
|
Angiology . Vol. 34, No. 1, 1983 Jan
|
A double blind placebo-controlled randomised crossover study was performed with Pentoxifylline (Trental 400 tablets with 400 mg active ingredient) in 24 patients (19 males, 5 females, aged between 40 and 71 years) suffering from peripheral occlusive arteriopathy of stage II severity (Fontaine's classification). In 12 patients (group I) the treatment was started with placebo, and in another 12 subjects with Pentoxifylline (group II). The dosage was 3 tablets of either formulation t.d.s., the treatment periods were 8 weeks each with a two week washout between. The standardised walking test (120 steps/min under metronome control) was used for the assessment of the walking capacity. There was a significant 60% increase in pain-free walking distance in either Pentoxifylline treatment periods, whereas there were no clinically relevant changes in the placebo periods. When comparing the two starting periods only, there was an increase in the Pentoxifylline group from 223 to 359 m on average and in the placebo group from 208 to 215 m, patients in both groups being comparable at basal level as to the distribution of sex, age, location of occlusion, duration of disease as well as in respect to the walking capacity. No adverse reactions were recorded during the trial.
|
https://pubmed.ncbi.nlm.nih.gov/6824189/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6824189
|
[
-0.1155799999833107,
1.2322685718536377,
-1.6973134279251099,
-1.4996552467346191,
0.3458898961544037,
0.9436563849449158,
1.4434361457824707,
-1.086298942565918,
0.24826715886592865,
0.6105005145072937,
0.33527567982673645,
0.51087486743927,
-0.20400355756282806,
-0.026491491124033928,
0.16206195950508118,
-0.34350889921188354,
-0.47063836455345154,
-0.828499972820282,
0.17139269411563873,
-1.1192412376403809,
0.0718829557299614,
0.4921679198741913,
-0.5948060154914856,
-0.7435134649276733,
0.41058364510536194,
-0.9185596108436584,
-0.16096211969852448,
0.9987407922744751,
-0.3447311818599701,
1.0362017154693604,
-0.19331017136573792,
-1.1347053050994873,
1.0570815801620483,
0.4436749219894409,
-0.16310115158557892,
0.6222819685935974,
0.5102829933166504,
0.4603129029273987,
-0.5575822591781616,
-0.4136216938495636,
1.6166527271270752,
0.03080916404724121,
-0.25374457240104675,
-0.332925409078598,
0.46147480607032776,
0.6756360530853271,
0.301693856716156,
-0.11550737172365189,
-0.34032201766967773,
-0.008482502773404121,
0.1493426263332367,
0.32667842507362366,
-0.31614822149276733,
-0.29395321011543274,
1.224065899848938,
-0.4618667662143707,
0.48036593198776245,
0.48783522844314575,
0.18125762045383453,
-0.7621749043464661,
0.8674161434173584,
0.10500068962574005,
0.17862911522388458,
0.2641824185848236,
-0.01640845276415348,
-0.2527696192264557,
-0.3067361116409302,
0.807601273059845,
-0.3983559012413025,
0.896674633026123,
-0.954685628414154,
0.15409234166145325,
0.41388654708862305,
0.09771765023469925,
-0.33888527750968933,
1.087597370147705,
0.0971100851893425,
0.6996356248855591,
0.6191108226776123,
0.16398201882839203,
-0.9089195728302002,
0.3556615114212036,
0.10887172073125839,
0.1328357458114624,
-0.053671713918447495,
0.36544227600097656,
-0.8488427400588989,
-0.34064507484436035,
0.17903435230255127,
-0.9300745129585266,
0.34254300594329834,
-0.33801811933517456,
-1.2996104955673218,
0.2355145812034607,
-0.5159969925880432,
0.16307125985622406,
0.03002006933093071,
-0.24391883611679077,
-0.4176422953605652,
0.027955515310168266,
0.13217569887638092,
-0.3863840103149414,
0.15854115784168243,
-0.4167323410511017,
-0.4823349714279175,
-0.34946301579475403,
0.07374916970729828,
-0.7744423747062683,
-0.845720112323761,
-1.066788911819458,
-0.08158452063798904,
-0.18642117083072662,
-0.5834199786186218,
0.04291869327425957,
1.212013602256775,
0.13148899376392365,
0.26011040806770325,
0.16159434616565704,
-0.4715743958950043,
-0.19658230245113373,
0.19197212159633636,
0.8367822766304016,
-0.26567375659942627,
0.45789647102355957,
-0.12403795123100281,
0.2608203887939453,
0.057633981108665466,
0.08068356662988663,
0.19721920788288116,
-0.5289221405982971,
-0.6905556917190552,
0.37476685643196106,
0.060482367873191833,
-0.30422016978263855,
-0.9182789921760559,
-0.38462892174720764,
-0.06504318118095398,
1.1081093549728394,
0.01483942475169897,
-0.6360094547271729,
0.16137181222438812,
0.2919405698776245,
-0.23711611330509186,
-0.0016694676596671343,
-0.6035217046737671,
0.317408949136734,
-0.4585159420967102,
0.1556631326675415,
-0.33163371682167053,
-0.22637949883937836,
-0.424932599067688,
0.23959247767925262,
-0.24764014780521393,
-0.16863088309764862,
-0.3899681568145752,
0.20505326986312866,
0.1728518009185791,
0.2998231053352356,
0.09740622341632843,
0.040888331830501556,
0.09559830278158188,
-0.06060661002993584,
0.2224721759557724,
-0.054711245000362396,
0.33399704098701477,
0.24273592233657837,
-0.1183825135231018,
-0.07023268938064575,
0.507918119430542,
0.14220401644706726,
-0.5532687306404114,
0.37442779541015625,
0.5631680488586426,
0.36869722604751587,
-0.20004303753376007,
0.09424591809511185,
0.6090418696403503,
0.2069052755832672,
0.26600396633148193,
0.04735485836863518,
-0.10882262885570526,
-0.04371160641312599,
0.046405062079429626,
-0.18051552772521973,
-0.3172532320022583,
-0.5284498333930969,
-0.23065268993377686,
-0.18848063051700592,
-0.2626521587371826,
0.3945636451244354,
0.2501771152019501,
0.11018683016300201,
-0.1436929702758789,
0.38513875007629395,
0.46536728739738464,
-0.10622726380825043,
-0.2012120634317398,
0.21212849020957947,
0.349044531583786,
-0.1531846821308136,
0.14306442439556122,
0.32886776328086853,
0.028333822265267372,
0.14878951013088226,
-0.05195792391896248,
0.051197733730077744,
-0.5301142334938049,
-0.14337041974067688,
0.03747602924704552,
-0.02693960815668106,
0.45583832263946533,
0.10471726208925247,
-0.3308858573436737,
-0.05602060258388519,
0.06594907492399216,
0.3032883107662201,
-0.1405668407678604,
0.00867469608783722,
-0.012369484640657902,
0.0415554940700531,
-0.01542677078396082,
-0.2572445869445801,
0.002308663446456194,
0.047992732375860214,
-0.3375180661678314,
0.09407227486371994,
-0.027064066380262375,
0.31008291244506836,
-0.16071249544620514,
-0.30148014426231384,
-0.33152326941490173,
0.07005035132169724,
-0.13778890669345856,
-0.20820271968841553,
-0.060482025146484375,
-0.012928456999361515,
0.03357066214084625,
0.2017054408788681,
-0.053996454924345016,
0.28412047028541565,
0.15701964497566223,
-0.5429731011390686,
-0.1548529714345932,
-0.3530994951725006,
-0.0038998627569526434,
0.3539539873600006,
-0.09201689064502716,
0.46191826462745667,
0.14273099601268768,
-0.030549436807632446,
-0.14737460017204285,
-0.32342469692230225,
0.0515606589615345,
0.12496789544820786,
-0.26938727498054504,
-0.20766153931617737
] |
6,824,247 |
Evaluation of tamoxifen doses with and without fluoxymesterone in advanced breast cancer.
|
Tormey D C DC, Lippman M E ME, Edwards B K BK, Cassidy J G JG
|
Annals of internal medicine . Vol. 98, No. 2, 1983 Feb
|
From a group of 108 female patients with measurable and/or evaluable metastatic breast carcinoma, 52 were randomized to receive tamoxifen and 56 to receive tamoxifen and fluoxymesterone. The fluoxymesterone dose, given orally twice a day, was 7 mg/m2 body surface area. The tamoxifen dose per patient, also given orally twice a day, ranged from 2 to 100 mg/m2 body surface area. Eighty-five percent of the patients had received previous chemotherapy and 60% previous hormone therapy. The complete and partial remission rate was better with the tamoxifen and fluoxymesterone regimen (p = 0.016), with remission rates of 15% for tamoxifen alone and 38% for the combination. The tamoxifen and fluoxymesterone regimen appeared to have higher remission rates in all subsets of pretreatment variables. Duration of remission with each regimen was similar, but the overall time to treatment failure for tamoxifen and fluoxymesterone was longer than for tamoxifen alone (180 versus 64 days, p = 0.01). Median survival with the combination was 380 days compared to 330 days for tamoxifen. No significant dose-response relationships emerged. Side effects were not different between dose levels or regimens except for the androgen effects in the tamoxifen and fluoxymesterone combination. These results suggest that there is no major dose-response effect for doses ranging from 2 to 100 mg/m2 body surface area given twice daily in this largely (94%) postmenopausal pretreated patient group, and that the tamoxifen and fluoxymesterone regimen is superior to tamoxifen alone.
|
https://pubmed.ncbi.nlm.nih.gov/6824247/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, U.S. Gov't, P.H.S."
] |
6824247
|
[
-0.003106624586507678,
0.3841000497341156,
-1.89283287525177,
-3.045097589492798,
0.7390187978744507,
1.2516965866088867,
0.4722062051296234,
0.2438521683216095,
-1.2163392305374146,
-0.5330601334571838,
0.05700191855430603,
0.43234601616859436,
-1.0638259649276733,
1.0808892250061035,
1.9338194131851196,
-0.781537652015686,
-1.8916120529174805,
-1.1550101041793823,
1.0196709632873535,
-3.497098922729492,
-0.3401375710964203,
-0.9746267199516296,
-1.7645198106765747,
-0.09956706315279007,
0.9247124195098877,
-1.26542067527771,
-0.7442108392715454,
1.8076512813568115,
-0.505308210849762,
0.916318953037262,
-0.9161224365234375,
-1.318525791168213,
0.7337639331817627,
-0.72063148021698,
1.209780216217041,
0.0763494074344635,
1.6605521440505981,
0.88188236951828,
-1.7811344861984253,
0.936320960521698,
0.7262181043624878,
0.0822441354393959,
-0.8274043202400208,
-0.7086336612701416,
0.6207166314125061,
-0.012404567562043667,
-0.1989968717098236,
0.10406982153654099,
1.5174933671951294,
0.6984895467758179,
-0.5078681707382202,
-0.29573386907577515,
-0.2990032434463501,
-1.3856463432312012,
2.059572219848633,
-0.5780105590820312,
-0.7608650326728821,
0.19396579265594482,
-0.7065215110778809,
0.8333351612091064,
0.7080986499786377,
0.37636902928352356,
-0.8585851788520813,
-0.5695980787277222,
0.03548027202486992,
1.0596673488616943,
-0.325186163187027,
0.8994986414909363,
0.16693119704723358,
1.7999340295791626,
-0.24747422337532043,
0.7439709305763245,
0.10190390795469284,
-0.1688542366027832,
0.5332700610160828,
0.1514950841665268,
-1.4491256475448608,
0.3345913589000702,
1.602872610092163,
-0.2290184199810028,
-0.7307479977607727,
0.536159336566925,
-0.4515755772590637,
0.05636995658278465,
-0.500010073184967,
0.24061568081378937,
-0.15910851955413818,
-0.14041244983673096,
0.4086913764476776,
-2.0704009532928467,
0.19574837386608124,
-1.1320420503616333,
-1.5501528978347778,
-0.18253709375858307,
-0.6145785450935364,
-0.01756332814693451,
0.07282000780105591,
-0.10518008470535278,
-0.16337350010871887,
-0.006347000598907471,
0.17376594245433807,
0.3160885274410248,
0.004117365460842848,
-0.3962850868701935,
-0.6729534268379211,
-0.6721144318580627,
-0.8112350702285767,
-0.9093827605247498,
-0.6116248965263367,
-1.5936962366104126,
-0.1688930094242096,
-0.6812593340873718,
-0.15338541567325592,
-0.20560617744922638,
0.012163174338638783,
0.8052691221237183,
-0.06378314644098282,
0.06872876733541489,
-0.2216065526008606,
-0.2837374806404114,
1.2257462739944458,
-0.07421858608722687,
-0.7795475125312805,
0.3506892919540405,
-0.3524516522884369,
0.22859370708465576,
0.06858757138252258,
-0.03833974525332451,
-0.5212753415107727,
-0.23257289826869965,
-0.27477172017097473,
1.1027828454971313,
-0.8007877469062805,
0.14607493579387665,
-1.702751874923706,
-1.1984363794326782,
-0.4012772738933563,
1.9259042739868164,
0.44866424798965454,
-0.16383710503578186,
0.05274955928325653,
0.27758079767227173,
-0.6193094253540039,
0.38395828008651733,
-1.4640613794326782,
0.3553423285484314,
0.6400063633918762,
0.09162639081478119,
-0.06521064043045044,
-0.35768070816993713,
-0.14049941301345825,
0.29622358083724976,
0.10097459703683853,
-0.23978587985038757,
0.03865506872534752,
0.11352761089801788,
-0.12541471421718597,
0.014769993722438812,
-0.49098819494247437,
-0.06226993352174759,
0.1309521645307541,
-0.24175499379634857,
0.11431234329938889,
-0.44390857219696045,
0.20091930031776428,
0.6285496950149536,
0.14297588169574738,
0.6250051259994507,
0.7408379912376404,
0.19840839505195618,
-0.926718533039093,
0.2889297604560852,
0.25191831588745117,
0.661794126033783,
0.09414640814065933,
-0.07614175230264664,
0.6898452639579773,
-0.5355951189994812,
0.6902613043785095,
0.475686639547348,
0.1766025722026825,
0.4089713394641876,
-0.10499673336744308,
-0.8464778065681458,
-0.2270796298980713,
-0.011586319655179977,
0.12106773257255554,
-0.6440489888191223,
0.2908600866794586,
0.4812447428703308,
0.5194140672683716,
-0.23993805050849915,
0.03853033110499382,
0.0297582745552063,
-0.1234082356095314,
-0.40786421298980713,
-0.1498430073261261,
0.42115116119384766,
0.8702635765075684,
0.07206380367279053,
0.052450813353061676,
0.13698378205299377,
0.7843679189682007,
0.6777439117431641,
-0.33156540989875793,
-0.07196622341871262,
-0.2699822783470154,
0.04711800441145897,
-0.26343318819999695,
0.005702903959900141,
0.6395825147628784,
-0.37109997868537903,
0.3095509707927704,
-0.18112772703170776,
0.03551885113120079,
0.23038752377033234,
-0.706367552280426,
0.44844576716423035,
-0.032562293112277985,
0.07257431745529175,
0.18842190504074097,
0.6583101153373718,
-0.24072502553462982,
0.3373629152774811,
-0.5064167380332947,
-0.05882139131426811,
0.07534324377775192,
-0.2595580518245697,
0.12648288905620575,
-0.44406095147132874,
-0.38736656308174133,
0.10773834586143494,
-0.12751340866088867,
-0.28535255789756775,
-0.21594099700450897,
-0.4349654018878937,
-0.3936217427253723,
0.36360785365104675,
-0.07279613614082336,
0.007705166470259428,
0.24220594763755798,
-0.9499421715736389,
-0.3387244641780853,
0.24186812341213226,
0.5370428562164307,
-0.030816685408353806,
-0.06096138060092926,
0.19719292223453522,
0.5251014828681946,
-0.08315595239400864,
-0.18848437070846558,
-0.24350710213184357,
-0.21566608548164368,
0.09156746417284012,
0.2880956530570984,
0.02313167229294777
] |
6,824,299 |
Subcutaneous bupivacaine for postoperative analgesia after herniorrhaphy.
|
Hashemi K K, Middleton M D MD
|
Annals of the Royal College of Surgeons of England . Vol. 65, No. 1, 1983 Jan
|
Subcutaneous injection of bupivacaine around the wound was used to provide postoperative analgesia in patients who had undergone herniorrhaphy. This proved to be an effective means of providing postoperative pain relief with no unwanted general or local effects.
|
https://pubmed.ncbi.nlm.nih.gov/6824299/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6824299
|
[
-1.8744457960128784,
0.27403128147125244,
-1.437851905822754,
-1.7849135398864746,
-1.2077866792678833,
-0.6644431352615356,
1.7071802616119385,
2.5252792835235596,
-1.9387527704238892,
-0.4497084319591522,
1.1823198795318604,
2.3269598484039307,
0.8737883567810059,
1.468894600868225,
0.23159204423427582,
0.10571347922086716,
1.9336284399032593,
1.1447968482971191,
0.14672981202602386,
-1.12189519405365,
-0.6848068237304688,
-0.8971242308616638,
-0.16026610136032104,
-0.8914685249328613,
1.3555189371109009,
1.4000753164291382,
0.397060364484787,
-0.732174277305603,
0.732123076915741,
1.9330518245697021,
0.37793463468551636,
0.022823091596364975,
-0.9244626760482788,
2.864929437637329,
-1.5395190715789795,
-0.3478287160396576,
1.242558479309082,
0.9934436678886414,
-1.6992601156234741,
-1.182094693183899,
1.2987964153289795,
2.266591787338257,
0.3777666985988617,
0.008637413382530212,
2.628476858139038,
0.18700122833251953,
-0.9045668244361877,
0.30483177304267883,
0.8486819267272949,
-1.632824182510376,
-0.07228653877973557,
-0.5681984424591064,
0.2642471194267273,
-0.019929364323616028,
0.5781337022781372,
0.4523249864578247,
1.5976272821426392,
1.2256639003753662,
0.6313773989677429,
-0.1564517617225647,
0.232929527759552,
-0.17116416990756989,
-0.20995716750621796,
-0.8529769778251648,
-0.3304812014102936,
-1.857521414756775,
0.6950512528419495,
-0.07882850617170334,
0.36589595675468445,
0.4555608630180359,
-0.2634997069835663,
0.21385955810546875,
0.7337663769721985,
0.6903941035270691,
1.1399623155593872,
1.056039810180664,
0.49807313084602356,
0.7243468761444092,
0.10902377218008041,
0.33448663353919983,
0.40675094723701477,
-1.2610501050949097,
0.6680864691734314,
0.6655633449554443,
-0.553182065486908,
0.6455222964286804,
-0.19498690962791443,
0.24045021831989288,
0.2908685803413391,
-0.25033774971961975,
-0.8411713242530823,
-0.9788035154342651,
-0.7748671770095825,
0.2165660560131073,
-1.3056600093841553,
-0.2783370316028595,
-0.11036105453968048,
-0.4928126335144043,
-1.2605760097503662,
-0.16172194480895996,
-0.11679792404174805,
-0.018614906817674637,
-0.3513071835041046,
-0.6829122304916382,
-0.30306121706962585,
0.35301363468170166,
-0.3853514492511749,
-0.484547883272171,
-0.314581960439682,
-0.5188309550285339,
1.490890622138977,
-1.3028558492660522,
0.08289598673582077,
-0.23250877857208252,
-0.10433695465326309,
0.7250805497169495,
-0.2271387130022049,
0.009658521972596645,
0.5799265503883362,
-0.3581721782684326,
0.5869951844215393,
1.2298437356948853,
-0.9203426241874695,
1.3374933004379272,
-0.1455846130847931,
0.26822566986083984,
0.02107815258204937,
1.641261339187622,
-0.799961507320404,
-0.1557857096195221,
0.5178541541099548,
0.9788877964019775,
0.6495476961135864,
-0.11046715825796127,
-1.8183586597442627,
-0.4538486897945404,
-0.21879728138446808,
0.5928301811218262,
-0.2538057863712311,
0.10226520150899887,
0.2418336123228073,
0.37845832109451294,
0.25973987579345703,
0.3870481252670288,
-1.1818901300430298,
-0.5369939804077148,
0.01081415917724371,
0.8141295909881592,
-1.8725515604019165,
0.5882130861282349,
0.4562060534954071,
-0.33080601692199707,
0.07199718803167343,
-0.40929779410362244,
1.1308461427688599,
-0.03867745026946068,
-0.453439861536026,
0.3844914734363556,
0.7308586239814758,
-0.23682089149951935,
-0.4000271260738373,
0.03369896113872528,
-0.40185245871543884,
-1.067124843597412,
-0.09946896880865097,
-1.3733887672424316,
-0.8737221956253052,
-0.4781006872653961,
0.4929191470146179,
-0.300091415643692,
-1.0405857563018799,
0.27839338779449463,
-0.3690754771232605,
-0.22744573652744293,
-0.9716176986694336,
0.6789755821228027,
0.6263620257377625,
0.22459828853607178,
1.1091092824935913,
-1.1272073984146118,
0.07281471788883209,
-0.12531527876853943,
0.7245492339134216,
0.21493661403656006,
0.06786727905273438,
0.045044854283332825,
-0.31084394454956055,
-0.4160015881061554,
-1.0899443626403809,
0.7462154626846313,
0.6478475332260132,
0.16986913979053497,
-0.7502683401107788,
0.4286857545375824,
-0.16184990108013153,
-0.016536042094230652,
-1.017767310142517,
-0.12388885766267776,
0.4448646903038025,
-0.15804548561573029,
-0.04859631881117821,
0.8216700553894043,
-1.1351816654205322,
0.4869540333747864,
0.009583190083503723,
-0.006714173126965761,
-0.12695010006427765,
0.7118856310844421,
-0.39821484684944153,
0.5760570168495178,
-0.5917798280715942,
-0.1523195505142212,
0.21627286076545715,
-0.05681980401277542,
0.16222892701625824,
0.2967413365840912,
-0.1016487404704094,
0.10177194327116013,
-0.28805673122406006,
0.19888891279697418,
-0.29551780223846436,
-0.02243119664490223,
-0.0897098034620285,
0.0675007700920105,
0.003138095373287797,
0.31078699231147766,
-0.04679727926850319,
-0.14608950912952423,
0.33046281337738037,
0.06967519968748093,
0.46587374806404114,
0.8260664939880371,
-0.1236388236284256,
0.02779276669025421,
-0.22263124585151672,
0.8397717475891113,
0.1686580628156662,
-0.12314587831497192,
0.22319847345352173,
0.06225203722715378,
0.01371702365577221,
-0.3947213888168335,
-0.7367556691169739,
-0.18894870579242706,
-0.07142520695924759,
0.8676088452339172,
0.7724803686141968,
0.4719020426273346,
-0.158765971660614,
-0.0028960038907825947,
-0.10344690829515457,
-0.17250880599021912,
0.3531813621520996,
-0.36355409026145935,
-0.011872966773808002,
-0.2964818477630615
] |
6,824,300 |
Plain bupivacaine 0.5%: a preliminary evaluation as a spinal anaesthetic agent.
|
Ryan D W DW, Pridie A K AK, Copeland P F PF
|
Annals of the Royal College of Surgeons of England . Vol. 65, No. 1, 1983 Jan
|
Three hundred and forty consecutive patients received successful spinal anaesthesia with 0.5% plain bupivacaine. A small randomised study of 40 of these cases showed little difference between 3.5 and 3 ml; however, analysis of its use in 200 patients receiving 3.5 ml (mean block T10.5 +/- 1 segment) and 100 receiving 3 ml (T10 +/- 0.5 segment) confirmed the impression that the smaller volume produced a more limited range of segmental block, which was desirable notably in the over-70-year age group. The main complications were hypotension (14.1%) and headache (1.5%).
|
https://pubmed.ncbi.nlm.nih.gov/6824300/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6824300
|
[
-0.5012513399124146,
1.6966755390167236,
-1.3855723142623901,
-1.7506403923034668,
0.9015722870826721,
1.573824405670166,
0.23008741438388824,
-2.0928092002868652,
-0.556546688079834,
0.08954750001430511,
0.40300309658050537,
0.4182513952255249,
-0.7994500398635864,
0.3583991527557373,
-0.49261781573295593,
-0.15932978689670563,
-0.19604292511940002,
-0.8856202960014343,
-0.23946602642536163,
-1.7694536447525024,
0.11438308656215668,
0.3821988105773926,
-0.2111947238445282,
-0.31186798214912415,
0.04184914007782936,
-0.3535555303096771,
1.1756844520568848,
0.9585665464401245,
0.19428467750549316,
0.25598081946372986,
0.49104607105255127,
-0.38076701760292053,
0.668273389339447,
0.2082366794347763,
-0.3294653296470642,
-0.6376579403877258,
1.0654493570327759,
-0.1566980630159378,
0.5811789631843567,
-0.530326783657074,
0.12752941250801086,
0.7943902015686035,
0.8635172843933105,
-0.3120204508304596,
0.2983597218990326,
-0.5567795038223267,
0.36647602915763855,
-0.7907902002334595,
0.30529189109802246,
0.28263723850250244,
-0.39613163471221924,
0.3386416733264923,
-0.8424392938613892,
-0.08738454431295395,
0.5315637588500977,
-0.43960997462272644,
0.4729287326335907,
0.397521048784256,
0.47390276193618774,
-0.6602491736412048,
0.7187062501907349,
0.46926096081733704,
0.40306371450424194,
0.07877223193645477,
0.4472775161266327,
-0.45032328367233276,
-0.4093802273273468,
0.21043990552425385,
-0.6904526352882385,
-0.41288769245147705,
-0.6738741993904114,
-0.17051611840724945,
-0.20817555487155914,
-0.2038893848657608,
0.2780722379684448,
0.40122300386428833,
0.39625462889671326,
0.7931122183799744,
0.5309746265411377,
0.8460074067115784,
-0.6669498085975647,
-0.2287440001964569,
0.0946488231420517,
0.06338577717542648,
0.8176478147506714,
0.4743300676345825,
-0.7764478325843811,
-0.1825788915157318,
-0.30559664964675903,
-0.9753124713897705,
-0.003936151508241892,
-0.804625391960144,
-0.5553056597709656,
-0.6000577211380005,
-0.8310880064964294,
0.6081148386001587,
0.4326300024986267,
-0.5837213397026062,
-0.4132818579673767,
0.024791238829493523,
0.026991765946149826,
-0.2321256548166275,
-0.36970019340515137,
-0.14247189462184906,
-0.06657075881958008,
-0.523367166519165,
0.11590147018432617,
-0.5011855959892273,
0.2504490613937378,
-0.7484449744224548,
0.5469902157783508,
-0.6147750616073608,
-0.7189643979072571,
-0.9431047439575195,
0.3837706446647644,
0.44233834743499756,
0.19878233969211578,
-0.14072071015834808,
0.26224204897880554,
-0.24176718294620514,
0.42722389101982117,
0.2394559383392334,
-0.10878739506006241,
0.2867760956287384,
0.2464790940284729,
-0.0497981496155262,
0.668386697769165,
0.7137670516967773,
-0.2687416970729828,
-0.2770545780658722,
-0.6399845480918884,
-0.04894663020968437,
0.5098661780357361,
-0.12426415830850601,
-0.800048828125,
0.09989071637392044,
-0.245210200548172,
0.7813792824745178,
0.7508969306945801,
-0.32617756724357605,
0.25719305872917175,
0.540389895439148,
-0.14633554220199585,
-0.4468100666999817,
-0.8356438279151917,
0.14617638289928436,
-0.6828823685646057,
-0.0896366611123085,
-1.0032953023910522,
-0.3744278848171234,
0.05922790989279747,
-0.29591044783592224,
-0.3606778681278229,
-0.08361399173736572,
0.35938534140586853,
0.61086505651474,
0.41323474049568176,
0.5014018416404724,
0.4187855124473572,
-0.5272342562675476,
0.3633542060852051,
-0.23414289951324463,
-0.3329026997089386,
-0.6161346435546875,
0.455597847700119,
-0.12559880316257477,
0.12606368958950043,
-0.057508450001478195,
-0.4223485291004181,
-0.003832506015896797,
-0.7190160155296326,
0.22851760685443878,
-0.06824497878551483,
0.20430132746696472,
0.1978646218776703,
-0.1670677363872528,
0.7661241292953491,
-0.08781715482473373,
0.859850287437439,
0.38543832302093506,
0.21003232896327972,
-0.24781434237957,
0.14368848502635956,
-0.21576860547065735,
-0.6810197830200195,
-0.11636029183864594,
-0.3031840920448303,
-0.03552059456706047,
-0.37724217772483826,
0.34664610028266907,
0.08549312502145767,
-0.02092769555747509,
-0.10347846895456314,
-0.025160398334264755,
0.757209837436676,
0.34893062710762024,
-0.37409135699272156,
0.07369918376207352,
0.9387168288230896,
-0.44816020131111145,
0.24077178537845612,
0.1398162692785263,
0.20566701889038086,
0.2591540813446045,
0.16924068331718445,
-0.5439400672912598,
-0.0770639032125473,
0.18038594722747803,
-0.5093348622322083,
-0.21946221590042114,
0.1302020251750946,
-0.04644722118973732,
-0.12042286247015,
0.03386252373456955,
-0.038853079080581665,
0.23290783166885376,
0.31860417127609253,
-0.07312595844268799,
-0.23477981984615326,
0.1580587476491928,
0.4235890805721283,
-0.24329084157943726,
-0.37538209557533264,
-0.2818436920642853,
-0.050700802356004715,
-0.1360410451889038,
0.07405295968055725,
0.04876316711306572,
0.23990286886692047,
-0.26542598009109497,
0.03215938061475754,
-0.41070660948753357,
-0.06280884891748428,
-0.02983248420059681,
-0.06598323583602905,
0.5734078884124756,
-0.044571712613105774,
-0.02606898918747902,
0.030546370893716812,
0.31540659070014954,
-0.6352031230926514,
-0.14259329438209534,
0.1996792107820511,
-0.20638634264469147,
0.3490035831928253,
-0.08697080612182617,
-0.0092992652207613,
0.6164184212684631,
-0.2507941722869873,
0.044971611350774765,
0.21631379425525665,
0.4572943150997162,
-0.05066628009080887,
0.18074576556682587,
-0.10768941044807434,
-0.32894641160964966
] |
6,824,358 |
Topical steroids and UV radiation in psoriasis.
|
Petrozzi J W JW
|
Archives of dermatology . Vol. 119, No. 3, 1983 Mar
|
This study evaluates the benefits of a potent and midstrength topical steroid compared with simple lubricating agents when used in combination with erythemagenic doses of sunlamp fluorescent UV irradiation in psoriasis. Twenty-six patients were studied in a bilateral symmetrical comparison. No significant differences were observed between topical corticosteroids and lubricants in the number of patients achieving a 75% or greater resolution of psoriasis. Topical corticosteroids did not reduce the number of treatments required for clearing. We did not observe faster recurrences in sites treated with topical corticosteroids. More severe burns and slightly less effectiveness were noted in patients irradiated five times weekly compared with three.
|
https://pubmed.ncbi.nlm.nih.gov/6824358/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6824358
|
[
1.1863056421279907,
1.6801601648330688,
-2.036339282989502,
-2.3248424530029297,
-0.5616136193275452,
-0.8841646313667297,
-0.3524746298789978,
0.5273976922035217,
-1.8023065328598022,
-0.7844733595848083,
1.8740593194961548,
2.7430450916290283,
-1.472385048866272,
-0.3072909116744995,
-0.7641752362251282,
0.5071017146110535,
0.17106786370277405,
0.37275391817092896,
1.1032577753067017,
-1.7119626998901367,
-0.6604447364807129,
0.4778884947299957,
0.5810478925704956,
1.0199365615844727,
1.1649805307388306,
-1.0074747800827026,
-0.7786885499954224,
0.33599311113357544,
0.839667797088623,
1.2670305967330933,
-0.8780646920204163,
0.44679489731788635,
0.7713468670845032,
-0.9866636395454407,
-0.39050301909446716,
-1.1905827522277832,
0.9323378205299377,
0.313392698764801,
-0.7290828227996826,
0.36432287096977234,
1.4637932777404785,
-0.07233664393424988,
-0.24542152881622314,
0.09704271703958511,
2.203221559524536,
-0.5354412198066711,
0.5057101249694824,
0.9090679287910461,
0.37740030884742737,
-1.632754921913147,
0.5464142560958862,
0.20820586383342743,
0.11221359670162201,
0.7720696330070496,
1.7050434350967407,
1.2182073593139648,
0.2949773967266083,
1.630573034286499,
0.5239690542221069,
-0.5482739210128784,
1.1917089223861694,
0.46064677834510803,
-0.6593455672264099,
-0.5711395740509033,
-0.1776515245437622,
-1.014829397201538,
0.05773845314979553,
0.2913546562194824,
-1.0280406475067139,
1.909502387046814,
-0.6013519167900085,
-0.17806531488895416,
0.4469430446624756,
-0.6916343569755554,
0.9028616547584534,
-0.019355401396751404,
-0.6458674073219299,
0.3112516701221466,
0.6493913531303406,
-0.3380838930606842,
-0.07316155731678009,
-0.20178700983524323,
-0.1039876788854599,
0.7717625498771667,
-0.425760418176651,
-0.28493061661720276,
-0.6775638461112976,
-0.4890986382961273,
0.2156088799238205,
-0.7338823080062866,
-0.5571613311767578,
-1.281962513923645,
-2.1220057010650635,
1.682425856590271,
-0.017424723133444786,
0.31283196806907654,
0.025184378027915955,
-0.45506662130355835,
-0.19135937094688416,
-0.3085964322090149,
0.45747601985931396,
-0.750511646270752,
-0.14754100143909454,
-0.3059898018836975,
-0.5728513598442078,
-0.6713441014289856,
-0.6912627816200256,
0.034999649971723557,
-0.48691850900650024,
-1.2924610376358032,
0.7344129681587219,
-0.8121791481971741,
-0.14607393741607666,
-0.36259517073631287,
0.8556293845176697,
0.7498599290847778,
0.3588867485523224,
0.7589637637138367,
-0.9405105113983154,
0.3194049298763275,
0.15122824907302856,
-0.025019964203238487,
-0.25203198194503784,
0.9127864837646484,
-0.5706140398979187,
0.24811215698719025,
-0.1764366626739502,
0.9839661121368408,
-0.6646779775619507,
0.11421728134155273,
-0.25147759914398193,
0.590165913105011,
0.5088054537773132,
0.18021635711193085,
-0.906936764717102,
-0.296072781085968,
0.7672543525695801,
1.6378730535507202,
0.0586763434112072,
-0.31663456559181213,
0.06266508251428604,
0.4456212818622589,
-0.7503572702407837,
0.29409947991371155,
-1.2203923463821411,
-0.8885804414749146,
-0.8333249688148499,
0.828533947467804,
-0.7907609939575195,
0.11606273055076599,
0.14116664230823517,
-0.16915814578533173,
0.3410399556159973,
0.40004289150238037,
0.23285891115665436,
0.20714016258716583,
1.1707496643066406,
-0.08827147632837296,
0.507233738899231,
0.07736613601446152,
0.2384793907403946,
-0.7955318689346313,
0.5809102058410645,
-0.15336984395980835,
0.12855224311351776,
-0.1815769225358963,
-0.08631579577922821,
0.2000773400068283,
-0.37302231788635254,
0.08744372427463531,
-0.8122004270553589,
0.18412542343139648,
0.2347530871629715,
-0.1785767823457718,
0.3298605978488922,
0.2382918894290924,
0.3247625231742859,
-0.1500159054994583,
0.8513731956481934,
0.023892367258667946,
-0.10408174991607666,
-0.043859053403139114,
-0.3466795086860657,
0.1607547551393509,
-0.287088006734848,
-0.4476473927497864,
-0.09800556302070618,
-0.05366252735257149,
-0.037269651889801025,
0.3909575045108795,
0.49017488956451416,
-0.322625070810318,
0.29702699184417725,
0.13219408690929413,
0.49486908316612244,
-0.45964327454566956,
-0.18115349113941193,
0.2570764124393463,
-0.2596922218799591,
-0.4770757853984833,
0.14030496776103973,
0.06970176845788956,
-0.38109898567199707,
0.9277100563049316,
-0.2646337151527405,
-0.6191823482513428,
0.026896009221673012,
0.1826457530260086,
-0.46380653977394104,
0.04070177674293518,
0.4607541859149933,
-0.15194407105445862,
0.14218948781490326,
0.3482016921043396,
-0.08754526823759079,
0.4160674214363098,
-0.024751439690589905,
0.24765336513519287,
-0.059250298887491226,
-0.3182813227176666,
-0.12154220044612885,
-0.2982165217399597,
-0.11866206675767899,
-0.09842032194137573,
0.3146146535873413,
0.1003592312335968,
-0.25200673937797546,
0.0632338747382164,
0.0537920705974102,
0.22053392231464386,
0.30817514657974243,
-0.05537884309887886,
-0.1722593605518341,
0.28930044174194336,
-0.12670540809631348,
0.7161332964897156,
0.7452187538146973,
-0.28340062499046326,
0.19840595126152039,
0.3101007640361786,
0.12477947771549225,
-0.864799976348877,
0.0036537761334329844,
0.10799330472946167,
0.04895167052745819,
-0.247597798705101,
0.24982841312885284,
0.20569118857383728,
0.02225426398217678,
-0.0067117842845618725,
0.16994479298591614,
0.321249395608902,
-0.04524502903223038,
0.3810921609401703,
-0.085690937936306,
-0.20141687989234924
] |
6,824,435 |
The influence of hair-removal methods on wound infections.
|
Alexander J W JW, Fischer J E JE, Boyajian M M, Palmquist J J, Morris M J MJ
|
Archives of surgery (Chicago, Ill. : 1960) . Vol. 118, No. 3, 1983 Mar
|
The influence of preoperative shaving v clipping on wound infection rate was studied in 1,013 patients undergoing elective operations at a single hospital. Patients were prospectively randomized to be either shaved or clipped the night before or the morning of operation. The AM clipper method was associated with significantly fewer infections than were the other methods, both at discharge and at 30-day follow-up. The greatest benefit was in the group with clean wounds. For each 1,000 patients treated, a savings of approximately $270,000 could be realized if the AM clipper method replaced shaving for preoperative hair removal. Preoperative shaving is deleterious, and the practice should be abandoned.
|
https://pubmed.ncbi.nlm.nih.gov/6824435/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6824435
|
[
-2.70929217338562,
3.0718095302581787,
-0.6036427021026611,
-0.4730442464351654,
0.48365166783332825,
1.1098837852478027,
-0.03789544850587845,
-0.1139000877737999,
-0.641978919506073,
0.4401487708091736,
0.043458614498376846,
0.43702417612075806,
0.8174878358840942,
1.0721678733825684,
1.1406878232955933,
0.5097431540489197,
0.7617522478103638,
-0.19223734736442566,
-0.16805744171142578,
-0.4525967836380005,
-0.6430924534797668,
0.05172129347920418,
-0.46044743061065674,
-0.2593626081943512,
0.6312845945358276,
-0.03520849719643593,
0.9702691435813904,
0.20884735882282257,
1.0550460815429688,
1.50624418258667,
0.5553282499313354,
0.19735540449619293,
-0.9574851393699646,
0.8254585862159729,
-0.49997594952583313,
0.3627547323703766,
0.09553086757659912,
0.2881702482700348,
-0.34258168935775757,
-0.19839565455913544,
1.1565237045288086,
-0.2065342664718628,
-0.5621824860572815,
0.22276701033115387,
0.5270953178405762,
-0.10411839932203293,
0.2842549681663513,
0.5210158824920654,
0.0472223162651062,
-0.9503263235092163,
-0.737793505191803,
0.1773713231086731,
-1.0914409160614014,
0.03082711435854435,
0.8515399694442749,
0.8570299744606018,
0.45671117305755615,
-0.2526211142539978,
0.3854411542415619,
-0.66429603099823,
0.7096769213676453,
-0.018670348450541496,
-0.5389353036880493,
-0.8010477423667908,
-1.3471182584762573,
-0.6649059653282166,
-0.16970139741897583,
0.4180903136730194,
-1.1264081001281738,
0.5437801480293274,
0.03570812940597534,
-0.9802550077438354,
0.42911097407341003,
-0.1952124685049057,
0.9923905730247498,
1.5630732774734497,
0.11316318064928055,
0.5802704691886902,
0.833828866481781,
0.017769357189536095,
0.5197550654411316,
-0.5573752522468567,
0.14623546600341797,
-0.31044435501098633,
-0.0065753948874771595,
-0.3545820713043213,
0.022976912558078766,
-0.523844838142395,
0.5975202322006226,
-0.3543684482574463,
-0.4467807710170746,
0.017829090356826782,
-0.4308141767978668,
0.6119598150253296,
-0.37857362627983093,
-0.36181196570396423,
0.3984237015247345,
-0.43921348452568054,
-1.0875742435455322,
-0.1953893005847931,
0.2736508846282959,
0.15559762716293335,
-0.24782878160476685,
-0.7173567414283752,
-0.35367465019226074,
-0.40685561299324036,
-0.355518102645874,
-1.1065706014633179,
-0.3030429184436798,
-0.21267306804656982,
0.45190373063087463,
-1.1045883893966675,
0.25083261728286743,
-0.18813636898994446,
-0.4736422896385193,
-0.42934083938598633,
0.1715308427810669,
-0.26510900259017944,
0.3914344906806946,
-1.0871131420135498,
0.8333917260169983,
-0.3455813229084015,
-0.33988189697265625,
0.115082286298275,
-1.1387723684310913,
0.0397869236767292,
-0.28787630796432495,
1.6256624460220337,
0.25316688418388367,
0.4823695719242096,
-0.5044786334037781,
0.7536658048629761,
-0.40698298811912537,
-0.07906780391931534,
-0.8325043320655823,
0.27625587582588196,
0.7370883822441101,
0.09845707565546036,
-0.3254576623439789,
-0.10235379636287689,
0.9361642599105835,
-0.019646648317575455,
-0.44251030683517456,
0.3171773850917816,
-1.0760159492492676,
-0.07595951855182648,
-0.9427017569541931,
0.7240305542945862,
-1.1852014064788818,
-0.061680279672145844,
-0.2981318533420563,
-0.5723433494567871,
-0.35593166947364807,
-0.09691017121076584,
0.260007381439209,
-0.08410686999559402,
0.12331966310739517,
0.8099899888038635,
-0.011409604921936989,
0.3367486596107483,
0.060241516679525375,
-0.1895233690738678,
0.46077948808670044,
-0.8199409246444702,
-0.2373621165752411,
-0.31466415524482727,
0.2294638752937317,
-0.2960038483142853,
0.4714672863483429,
-0.39572468400001526,
-0.23906676471233368,
0.38070324063301086,
0.1915825605392456,
0.6008472442626953,
-0.44606995582580566,
-0.19322176277637482,
0.25259578227996826,
0.5265218019485474,
0.10729283839464188,
0.6314162015914917,
0.5435404777526855,
-0.43187907338142395,
-0.23349085450172424,
0.0580269917845726,
-0.051163822412490845,
0.03750360757112503,
0.14837142825126648,
-0.77005535364151,
-0.20753507316112518,
0.934044361114502,
0.11868946254253387,
-0.43658459186553955,
-0.025692932307720184,
0.018394768238067627,
0.45062777400016785,
0.35667702555656433,
-0.6569852232933044,
-0.6060839891433716,
0.1551303267478943,
-0.1260755956172943,
0.07888457179069519,
0.2638092339038849,
-0.8055760860443115,
0.3246459662914276,
0.48449110984802246,
-0.5328240990638733,
0.07503344118595123,
0.5944176912307739,
-0.09826022386550903,
0.06343837827444077,
-0.22175319492816925,
-0.4564739465713501,
0.24644796550273895,
0.04888178035616875,
0.22530204057693481,
-0.2161961942911148,
0.35552778840065,
0.2526839077472687,
-0.8750406503677368,
0.17866386473178864,
0.4211593568325043,
-0.03319017216563225,
0.17080296576023102,
0.34612786769866943,
-0.4700426757335663,
-0.17576636373996735,
-0.04048089683055878,
-0.051851704716682434,
0.5993895530700684,
0.17368221282958984,
-0.2854219973087311,
0.02297709695994854,
-0.022424060851335526,
-0.029257722198963165,
0.18511196970939636,
0.11011142283678055,
0.47487881779670715,
-0.3821692168712616,
-0.21723052859306335,
0.05482930690050125,
-0.011641629040241241,
-0.4380176365375519,
-0.7406848669052124,
-0.11950695514678955,
0.2333235889673233,
-0.37338462471961975,
0.3791203498840332,
0.13239309191703796,
-0.22698640823364258,
0.40049296617507935,
0.5750036835670471,
-0.13263428211212158,
-0.0631328672170639,
0.38565924763679504,
0.1720467358827591,
0.009248201735317707
] |
6,824,553 |
The prevention of recurrent suicidal acts.
|
Montgomery S A SA, Roy D D, Montgomery D B DB
|
British journal of clinical pharmacology . Vol. 15 Suppl 2, 1983
|
1 There have been few controlled prospective investigations into the prevention of suicidal behaviour and by and large they have failed to demonstrate the efficacy of social work, psychotherapy or psychiatric treatment. 2 A group of 58 high-risk patients with multiple episodes of suicidal behaviour was treated with mianserin 30 mg at night or placebo in a six month double-blind trial of the efficacy of an antidepressant in reducing suicidal behaviour. 3 Patients were screened for depression, schizophrenia and organic disease. Patients were diagnosed as suffering from personality disorders according to DSM-III criteria mainly borderline or histrionic. 4 There was no significant difference in outcome between the mianserin and placebo treated group at any point in the six month study. 5 An item analysis of the MADRS showed that at entry the item 'reduced appetite' predicted subsequent suicidal attempt. The total MADRS score did not predict further suicidal acts at entry but was highly significant at four weeks. At four weeks the items 'reduced sleep' and 'reduced appetite' were highly significant predictors of further suicidal acts and the items 'lassitude', 'suicidal thoughts', 'inability to feel' and 'pessimistic thoughts' were significant predictors.
|
https://pubmed.ncbi.nlm.nih.gov/6824553/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6824553
|
[
-2.1929819583892822,
1.7323909997940063,
-0.3108855187892914,
-0.32572582364082336,
0.38128340244293213,
-0.7845361232757568,
0.33917900919914246,
-0.7250753045082092,
0.0758858248591423,
0.21272699534893036,
-0.2641396224498749,
1.0527557134628296,
-0.5751518607139587,
0.7081021666526794,
-0.5659248232841492,
0.3397428095340729,
-0.6149297952651978,
0.20978717505931854,
1.269823670387268,
-1.5292036533355713,
-0.2915164530277252,
0.25574415922164917,
0.7894805073738098,
-0.04779953509569168,
-0.7083829641342163,
-0.11642356216907501,
-1.4517264366149902,
2.3082666397094727,
-0.7482876181602478,
0.6132017374038696,
-0.684812605381012,
-1.1241014003753662,
0.7991693019866943,
0.1083035096526146,
0.981765627861023,
-1.1217604875564575,
-0.2989621162414551,
0.16876143217086792,
-1.6004523038864136,
-0.3762463331222534,
0.3337486982345581,
1.1396150588989258,
-0.08865485340356827,
0.032525043934583664,
0.7634803652763367,
0.7938059568405151,
-0.24449791014194489,
0.388601690530777,
-0.4867250621318817,
0.12484987080097198,
-0.46653831005096436,
1.1126091480255127,
-0.8133667707443237,
-0.060205020010471344,
1.4749819040298462,
0.3247986435890198,
0.7363297343254089,
-0.006527975667268038,
0.6002951860427856,
-1.1078954935073853,
0.7958379983901978,
-0.1457854062318802,
-0.12366713583469391,
-0.13602305948734283,
-0.34221264719963074,
-0.5308736562728882,
-0.5188656449317932,
0.7051092982292175,
-0.042388301342725754,
0.5970227122306824,
-0.1677733063697815,
0.5161932706832886,
0.12593147158622742,
-0.6305727362632751,
0.5871927738189697,
-0.021036172285676003,
0.6560699343681335,
0.6533877849578857,
0.5188788771629333,
0.5621380805969238,
-0.4605974555015564,
0.2721366286277771,
-0.2488224357366562,
-0.0022562360391020775,
0.369354248046875,
0.5162968635559082,
-1.186578631401062,
-0.2725399434566498,
0.4552786350250244,
-1.0600589513778687,
1.2097536325454712,
-0.19220910966396332,
-0.8627595901489258,
0.6178799867630005,
-0.9939934015274048,
0.836471676826477,
-0.313092440366745,
-0.5614163279533386,
-0.32917270064353943,
-0.33234524726867676,
0.23818370699882507,
-0.45282769203186035,
-0.6670213341712952,
0.018265563994646072,
-1.0482707023620605,
-0.17597150802612305,
-0.04119430109858513,
-0.11000192910432816,
-0.2838960289955139,
-0.030739841982722282,
1.1285548210144043,
-0.6975808143615723,
0.1471341997385025,
-0.7906391024589539,
0.07088681310415268,
0.43093162775039673,
0.08219451457262039,
-0.5138139724731445,
0.25469091534614563,
0.021280188113451004,
0.4698498845100403,
0.5736802220344543,
-0.45594507455825806,
-0.028576182201504707,
-0.20604261755943298,
0.8648946285247803,
-0.5734090209007263,
-0.2921414077281952,
0.10828020423650742,
-1.0622851848602295,
-0.7060984373092651,
0.7605114579200745,
-0.15254716575145721,
-0.26734015345573425,
-0.6826186776161194,
-0.32275688648223877,
0.1099979430437088,
1.4438832998275757,
-0.42829400300979614,
-0.7333921194076538,
-0.3638083040714264,
0.04057798162102699,
-0.3920242190361023,
0.9206270575523376,
-1.266837477684021,
-0.9113695621490479,
-0.18286369740962982,
0.1199466809630394,
-0.7402185797691345,
-0.5457522869110107,
0.3342764973640442,
0.7043898105621338,
0.39047834277153015,
-0.13768965005874634,
-0.10844845324754715,
0.6048911809921265,
0.1566184163093567,
-0.40428993105888367,
0.2421264946460724,
-0.5091781616210938,
-0.11514965444803238,
-0.5602878332138062,
0.49732500314712524,
-0.5169007182121277,
-0.25288182497024536,
0.060677655041217804,
0.2369663119316101,
0.10826350003480911,
0.15685555338859558,
-0.19559893012046814,
-1.0046976804733276,
0.3971199691295624,
-0.21298085153102875,
0.4812542796134949,
-0.14786897599697113,
0.059919361025094986,
0.15961690247058868,
0.011110298335552216,
0.5125940442085266,
0.11418414860963821,
-0.11295203119516373,
-0.05477919429540634,
-0.5307061672210693,
0.18454118072986603,
0.021286070346832275,
0.10985691845417023,
-0.7050459384918213,
-0.1568436175584793,
0.1736413687467575,
0.4718090891838074,
-0.1416877657175064,
0.24618253111839294,
0.5454153418540955,
-0.017189234495162964,
0.21270126104354858,
-0.2440565973520279,
-0.23825807869434357,
-0.28474873304367065,
0.3821682035923004,
-0.17050443589687347,
0.10985265672206879,
0.7610947489738464,
-0.1902543008327484,
0.058939799666404724,
-0.1455184519290924,
-0.13705722987651825,
-0.44347813725471497,
0.06493667513132095,
0.05511860176920891,
0.5613003373146057,
0.34776821732521057,
0.1169838234782219,
0.2064262181520462,
0.05109156295657158,
-0.17897212505340576,
0.20993664860725403,
0.2693389356136322,
0.0351204052567482,
-0.5274614691734314,
-0.2694542407989502,
-0.0744381919503212,
0.04309239983558655,
0.26693233847618103,
0.15826989710330963,
-0.2638075649738312,
-0.24060779809951782,
0.02559075318276882,
-0.1396493911743164,
-0.06428100168704987,
0.2814163565635681,
-0.35545992851257324,
-0.1394553780555725,
-0.1554090827703476,
-0.23831762373447418,
0.05980278551578522,
-0.12381009757518768,
0.06681293249130249,
0.0916256308555603,
-0.041769757866859436,
-0.08253901451826096,
0.011182129383087158,
-0.4551454484462738,
-0.273955762386322,
-0.2908285856246948,
0.20058971643447876,
0.02361978217959404,
-0.3918900787830353,
0.46096208691596985,
-0.015531233511865139,
-0.007726124022156,
0.007275019772350788,
-0.01802908070385456,
-0.03238286077976227,
-0.2731652855873108,
0.4660623371601105,
-0.14832402765750885
] |
6,824,555 |
Mianserin and doxepin in the treatment of outpatient depression with anxiety.
|
Khan M C MC, Bennie E H EH, Stulemeijer S M SM, Ravens M A MA
|
British journal of clinical pharmacology . Vol. 15 Suppl 2, 1983
|
1 A double-blind group comparative trial was performed comparing mianserin (Bolvidon-Organon) and doxepin (Sinequan-Pfizer) in the treatment of depression with anxiety. 2 Sixty outpatients from two centres were divided into 'high' and 'low' severity groups, based on initial HRS scores, and treated for four weeks. 3 Standard rating scales for depression and anxiety demonstrated a substantial improvement with both drugs. However, no consistent difference in efficacy was found although the 'low severity' group appeared to respond better to mianserin. 4 There was a greater incidence of drug-related side-effects with doxepin treatment.
|
https://pubmed.ncbi.nlm.nih.gov/6824555/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6824555
|
[
-1.0790785551071167,
1.5536617040634155,
-1.7771025896072388,
-0.9153987765312195,
0.5928112268447876,
0.45535874366760254,
0.9687332510948181,
-0.19272786378860474,
-0.013477141968905926,
-0.6070162057876587,
-0.929519772529602,
1.920132040977478,
-0.8422598838806152,
0.5842925906181335,
0.25895965099334717,
0.2902742326259613,
-0.12048004567623138,
-0.2996893525123596,
0.7702311873435974,
-1.7393285036087036,
-0.7735946774482727,
0.3057059049606323,
-0.2918086051940918,
0.4347381889820099,
0.11774484813213348,
-1.035875916481018,
-0.15800471603870392,
1.2202214002609253,
-0.8277796506881714,
0.5505762696266174,
-0.12354213744401932,
-0.651533305644989,
0.07138340175151825,
-0.3208834230899811,
0.5185878872871399,
-0.09390761703252792,
-0.12302232533693314,
-0.08275584876537323,
-0.5335437655448914,
-0.10666950792074203,
0.8805240392684937,
1.1927707195281982,
0.4231853783130646,
-0.3651543855667114,
1.2214020490646362,
0.36336758732795715,
-0.007009770255535841,
0.3908657431602478,
0.226161390542984,
-0.5071337223052979,
0.8760252594947815,
0.2933521270751953,
-0.4094344675540924,
-0.26328688859939575,
2.467900276184082,
-0.24264834821224213,
0.3947080075740814,
0.979482114315033,
0.17383605241775513,
-0.3432888686656952,
0.7328999042510986,
-0.3295617699623108,
-0.4014151990413666,
0.34596917033195496,
-0.40127789974212646,
0.18871697783470154,
0.7972697019577026,
-0.21099096536636353,
-0.5245813727378845,
0.6174777150154114,
-1.265031337738037,
0.13895565271377563,
0.6855859160423279,
-0.3578484356403351,
0.6674416065216064,
-0.25939837098121643,
-0.8734973073005676,
0.5717114210128784,
0.3723345696926117,
0.816527247428894,
-0.5690456628799438,
-0.3532007336616516,
-0.40695104002952576,
-0.9950413107872009,
0.35289934277534485,
-0.3712686598300934,
-0.8285547494888306,
-0.3939782679080963,
0.7659030556678772,
-0.922298789024353,
0.7302545309066772,
-0.5339351296424866,
-1.223562479019165,
0.9576274156570435,
-0.1221306324005127,
0.3333054780960083,
-0.8221046328544617,
-0.16721762716770172,
-0.6239193677902222,
0.11998969316482544,
0.14708678424358368,
-0.07911930233240128,
0.10120195895433426,
-0.3977193832397461,
-0.38629332184791565,
-0.27016112208366394,
-0.4604721665382385,
-0.8007951974868774,
-0.8866130709648132,
-0.754315197467804,
0.1073552668094635,
-0.5468915700912476,
0.19300805032253265,
-0.46267056465148926,
0.6126121282577515,
0.562152087688446,
0.8437606692314148,
-0.2110355794429779,
-0.44951796531677246,
-0.27615979313850403,
0.4561235010623932,
0.4415208399295807,
-0.19441822171211243,
0.5734425187110901,
-0.29503563046455383,
0.4118078649044037,
0.014859583228826523,
0.4037646949291229,
-0.41320645809173584,
-0.3409307897090912,
-0.4815714359283447,
0.611519455909729,
0.5216516256332397,
-0.6221233010292053,
-1.0187536478042603,
-1.1306782960891724,
-0.21588698029518127,
1.5951863527297974,
-0.2101559042930603,
-0.6376115679740906,
-0.41208750009536743,
0.7412664890289307,
-0.24584178626537323,
0.2909397482872009,
-1.006550669670105,
-0.3955550193786621,
-0.13255347311496735,
-0.07927178591489792,
-0.8850141763687134,
0.3351519703865051,
-0.2034149318933487,
0.49033719301223755,
0.8375188112258911,
-0.04387591779232025,
-0.2677439749240875,
0.5895235538482666,
0.5440826416015625,
0.1353207379579544,
-0.14024530351161957,
0.21424898505210876,
-0.5245339870452881,
-0.22211158275604248,
0.2504640817642212,
-0.09625791013240814,
-0.3382388651371002,
-0.15365393459796906,
-0.29255953431129456,
-0.11022501438856125,
0.3713780641555786,
-0.3045887053012848,
-0.8694724440574646,
-0.13817015290260315,
0.24372591078281403,
0.399885356426239,
0.35363349318504333,
0.21056148409843445,
0.5804951190948486,
-0.17773380875587463,
0.33393487334251404,
-0.019256586208939552,
-0.30951201915740967,
0.568814754486084,
-0.1263076514005661,
0.3250653147697449,
-0.4261086583137512,
-0.4288019835948944,
-0.5894770622253418,
-0.35903188586235046,
0.18431150913238525,
0.40837380290031433,
0.3236059844493866,
0.09322021901607513,
0.41673022508621216,
0.1553594321012497,
0.17140910029411316,
-0.38399842381477356,
-0.22503776848316193,
0.15678882598876953,
0.07497820258140564,
-0.273497998714447,
0.06282400339841843,
0.4177870750427246,
-0.41389763355255127,
0.5869694352149963,
-0.28823918104171753,
0.07093173265457153,
-0.4998738765716553,
0.04849361628293991,
-0.27303072810173035,
0.3294670283794403,
0.5701504945755005,
-0.2058580219745636,
0.29447486996650696,
0.5522964000701904,
0.5376847982406616,
0.4069778025150299,
0.08259444683790207,
0.49285635352134705,
-0.3424901068210602,
0.2950514256954193,
-0.27063190937042236,
-0.10172068327665329,
-0.25504401326179504,
-0.024093816056847572,
-0.314776211977005,
-0.24178160727024078,
0.11748902499675751,
0.32443177700042725,
0.1031939759850502,
-0.05373061075806618,
-0.12370914220809937,
-0.5638195872306824,
0.20426563918590546,
0.0762513279914856,
-0.2792288661003113,
-0.6264404058456421,
-0.05768397077918053,
-0.05537295341491699,
-0.13953648507595062,
-0.254373699426651,
-0.10629414021968842,
-0.3501273989677429,
0.14084525406360626,
-0.38011229038238525,
0.40041714906692505,
-0.5093184113502502,
-0.34049078822135925,
0.11250251531600952,
0.07064473628997803,
-0.09183844178915024,
-0.05182282626628876,
-0.021645305678248405,
-0.17685236036777496,
0.1355503499507904,
-0.2525501847267151,
-0.03120928630232811
] |
6,824,557 |
Mianserin, maprotiline and the electroencephalogram.
|
Sedgwick E M EM, Edwards J G JG
|
British journal of clinical pharmacology . Vol. 15 Suppl 2, 1983
|
1 EEGs were recorded from patients with depressive illness before and after four weeks of treatment with mianserin, maprotiline or placebo. 2 Visual analysis of the records showed a small but statistically significant increase in frequency of beta activity in the mianserin group. 3 One subject taking maprotiline developed spike and wave discharges but had no convulsive seizures. 4 The findings do not support those of previous studies. It seems that changes seen in the EEG early after treatment are not sustained for four weeks.
|
https://pubmed.ncbi.nlm.nih.gov/6824557/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6824557
|
[
-0.1162535697221756,
1.0642294883728027,
-0.7152538895606995,
-1.4835320711135864,
-0.41646283864974976,
1.4329291582107544,
0.6553573608398438,
-1.1200143098831177,
-1.2526777982711792,
1.7243624925613403,
0.014371909201145172,
1.7113198041915894,
-2.0351264476776123,
0.46856310963630676,
0.9590636491775513,
0.17049655318260193,
0.42043715715408325,
-1.3111838102340698,
0.9726405739784241,
-1.982622742652893,
0.05631650611758232,
-0.18900412321090698,
-0.18903477489948273,
-0.8598023056983948,
0.4925248622894287,
-0.5164476633071899,
-0.49238836765289307,
0.19061270356178284,
-0.8314487338066101,
1.9085897207260132,
1.227691650390625,
-0.04343106225132942,
0.43381133675575256,
-0.17359596490859985,
0.6912790536880493,
-0.643280565738678,
-0.4207022786140442,
-0.4100783169269562,
-1.0692232847213745,
-1.124406337738037,
-0.53635573387146,
0.0017616715049371123,
0.9420819282531738,
0.5888184905052185,
0.7424755692481995,
0.09384658187627792,
0.6798452734947205,
1.16923189163208,
0.21106113493442535,
-0.37515220046043396,
-0.5566347241401672,
1.0217530727386475,
-0.5003084540367126,
-0.8764890432357788,
2.295958995819092,
0.5083482265472412,
0.47368961572647095,
0.5320917367935181,
1.0507113933563232,
-0.46051597595214844,
1.0564404726028442,
0.10591865330934525,
-0.0021246529649943113,
-0.4628940224647522,
-0.09579695016145706,
-0.9575429558753967,
0.5504292249679565,
-0.684398353099823,
-0.866989254951477,
-0.1592002511024475,
-0.4729861319065094,
-0.14825092256069183,
0.30596932768821716,
-0.6363945007324219,
0.4155086278915405,
0.21476539969444275,
-0.15954884886741638,
0.11657784879207611,
0.8435948491096497,
0.6053582429885864,
0.08927499502897263,
-0.5153611302375793,
-0.4855320453643799,
0.10652713477611542,
-0.5517117977142334,
-0.07893496751785278,
-0.9967905879020691,
0.014619816094636917,
0.5984725952148438,
-0.26974165439605713,
-0.5295575857162476,
-0.5193830132484436,
-1.2469090223312378,
0.12861944735050201,
-0.40574660897254944,
0.5882747173309326,
-1.2081924676895142,
-0.1771358996629715,
-0.9574751257896423,
-0.21844954788684845,
-0.20087210834026337,
-0.5522742867469788,
-0.29198959469795227,
-0.13754889369010925,
-1.0351145267486572,
0.803130567073822,
-0.3881930410861969,
-0.7157737016677856,
-0.626774251461029,
-0.36415529251098633,
-0.6375475525856018,
-1.1635582447052002,
0.2755018472671509,
-0.03830462694168091,
0.21263906359672546,
-0.05808233842253685,
0.38072100281715393,
-0.3942292034626007,
-0.15525521337985992,
-0.4596627950668335,
0.5313887596130371,
0.46640563011169434,
-0.09753236174583435,
0.5668630003929138,
-0.4849227964878082,
0.1850898563861847,
0.1064264327287674,
0.15217635035514832,
-0.34029367566108704,
-0.6194032430648804,
-0.2711935341358185,
0.6809874176979065,
0.29199454188346863,
-0.6656965613365173,
-0.243654265999794,
-0.24284009635448456,
-0.17268219590187073,
0.8029759526252747,
0.08611512929201126,
-0.5570335984230042,
0.03797229751944542,
0.2670064866542816,
-0.04571360722184181,
0.28663739562034607,
-1.2490477561950684,
-0.47268182039260864,
-0.33342236280441284,
0.09172060340642929,
-0.9142412543296814,
0.27852320671081543,
0.09487880021333694,
0.6223234534263611,
0.6891429424285889,
-0.22530382871627808,
-0.007848885841667652,
0.13867177069187164,
0.5040234923362732,
-0.3794891834259033,
0.02535545825958252,
-0.6338726282119751,
-0.006230887025594711,
-0.2968987822532654,
0.2726970911026001,
0.15593034029006958,
-0.2851928472518921,
-0.2873130738735199,
0.26073774695396423,
-0.14196601510047913,
0.09405630826950073,
-0.1435932219028473,
-0.5052202343940735,
0.1442720741033554,
-0.14375658333301544,
0.8751292824745178,
0.21118782460689545,
0.06143729016184807,
0.5028300285339355,
0.18605464696884155,
0.23314765095710754,
-0.01911900006234646,
-0.5356914401054382,
-0.3358535170555115,
-0.7083257436752319,
0.24029771983623505,
0.005794894881546497,
0.2883390784263611,
-0.39707839488983154,
0.3477482795715332,
0.22322268784046173,
0.29655542969703674,
-0.05767297372221947,
-0.11074552685022354,
-0.1763201802968979,
0.2949456572532654,
0.7990466952323914,
0.14734706282615662,
0.03779398277401924,
0.35341280698776245,
0.22713713347911835,
0.11112825572490692,
0.14221909642219543,
0.34986260533332825,
-0.08598986268043518,
0.589948832988739,
0.2785109877586365,
-0.18236614763736725,
-0.9154637455940247,
0.11523504555225372,
0.3312458395957947,
0.4421842694282532,
0.38840821385383606,
-0.0077224550768733025,
0.200719952583313,
0.6864224076271057,
0.23929964005947113,
0.5549156665802002,
0.06050786003470421,
0.32353174686431885,
-0.592761218547821,
0.24416173994541168,
-0.41680631041526794,
-0.31714126467704773,
0.023197898641228676,
-0.08108192682266235,
-0.2401801198720932,
-0.469624787569046,
0.18009372055530548,
0.11738879978656769,
-0.03332160785794258,
-0.222805455327034,
0.07505474239587784,
-0.01276330091059208,
0.2005358189344406,
-0.3675934970378876,
-0.12373761832714081,
-0.2438008040189743,
0.1547887623310089,
-0.08487644046545029,
0.10482538491487503,
0.32790181040763855,
0.314787894487381,
-0.5829993486404419,
-0.061735596507787704,
-0.7122157216072083,
0.3047771453857422,
-0.5214336514472961,
-0.23839706182479858,
0.45337483286857605,
-0.04272904247045517,
-0.3299081027507782,
-0.13461217284202576,
-0.6431396007537842,
0.04172216355800629,
0.05209856107831001,
0.10453930497169495,
-0.05945000797510147
] |
6,824,556 |
Mianserin, maprotiline and intracardiac conduction.
|
Edwards J G JG, Goldie A A
|
British journal of clinical pharmacology . Vol. 15 Suppl 2, 1983
|
1 High speed surface electrocardiograms were recorded in 35 patients during the baseline and after four weeks' treatment in a placebo-controlled trial of mianserin and maprotiline in primary depressive illness. 2 Measurements of the RR, PR and QT intervals, QRS width and T wave height were made blind to patient, drug and treatment interval and compared with plasma drug concentrations. The presence or absence of cardiac arrhythmias was recorded. 3 The only significant findings were an increased heart rate and PR interval and decreased QTc interval in the maprotiline group. Only one patient receiving maprotiline had a cardiac arrhythmia. There was no significant correlation between measurements of ECG parameters and plasma drug levels. 4 The results confirm the lack of cardiac effects of mianserin and show both anticholinergic activity and effects of an intracardiac conduction in the case of maprotiline. The mechanisms of these effects are discussed.
|
https://pubmed.ncbi.nlm.nih.gov/6824556/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6824556
|
[
1.4045617580413818,
1.670788049697876,
-1.0819759368896484,
-2.347475051879883,
-0.10441044718027115,
0.6473217606544495,
1.7162721157073975,
-0.5205998420715332,
-1.0272682905197144,
0.9673780798912048,
-0.2652445137500763,
1.9462990760803223,
-1.5310920476913452,
0.13440653681755066,
0.8517391681671143,
0.6652979850769043,
0.1634952425956726,
-0.1674785166978836,
2.273611307144165,
-2.0988311767578125,
0.6232407093048096,
-0.6438422799110413,
-0.6381716132164001,
1.2092409133911133,
0.10040205717086792,
0.36684921383857727,
-0.2894449234008789,
1.2344008684158325,
-0.615901529788971,
1.6062833070755005,
0.7760137319564819,
-0.3109220564365387,
0.5478219389915466,
-0.36676493287086487,
-0.4512510299682617,
-1.0594184398651123,
0.9673345685005188,
-0.15388335287570953,
-0.6198713183403015,
-0.6396403312683105,
0.0365922786295414,
-0.2726844549179077,
0.42812737822532654,
0.9771009087562561,
1.4038769006729126,
0.1203312948346138,
-0.3729652166366577,
0.11508774757385254,
0.8156825304031372,
-0.7217774391174316,
-0.8674928545951843,
1.1570285558700562,
-0.6525709629058838,
0.4396115839481354,
2.045684814453125,
1.2694011926651,
1.112815260887146,
0.5296863317489624,
1.2773703336715698,
-0.18117336928844452,
0.7644792795181274,
0.5876028537750244,
0.42425236105918884,
0.860569953918457,
-0.3180180788040161,
-0.3458646833896637,
0.9275600910186768,
-0.7154962420463562,
-1.0298347473144531,
0.41359198093414307,
-0.3741055727005005,
0.9208911657333374,
-0.2907847762107849,
0.49370434880256653,
0.8124898076057434,
0.3298148810863495,
-1.1731574535369873,
1.4213850498199463,
0.2720267176628113,
0.4128064215183258,
-0.8786351084709167,
-1.038327932357788,
-0.3149755001068115,
-0.5228874087333679,
0.10370508581399918,
-0.06826668232679367,
-0.9558426737785339,
-0.3980947434902191,
0.44988277554512024,
-0.6851073503494263,
-0.4707474708557129,
-0.7528200149536133,
-1.190011739730835,
0.47720658779144287,
-1.5669194459915161,
0.7250760793685913,
-0.6096015572547913,
0.28683894872665405,
-0.5652825832366943,
-0.4933759868144989,
-0.29762133955955505,
-0.19649359583854675,
0.2686987519264221,
-0.023445652797818184,
-0.5200688242912292,
0.3911815285682678,
0.11522559076547623,
-0.3318687677383423,
-0.7009057998657227,
-0.40614432096481323,
0.03287544474005699,
-0.914942741394043,
0.09175145626068115,
-0.43494001030921936,
-0.4876338839530945,
0.6288303136825562,
0.4695581793785095,
0.2611413896083832,
-0.801752507686615,
-0.9566919803619385,
-0.09246324002742767,
0.32072752714157104,
0.0638490617275238,
0.27706795930862427,
-0.17888951301574707,
-0.3724098801612854,
0.40741267800331116,
-0.2844547927379608,
-0.28677648305892944,
-0.3710792064666748,
-0.6506389379501343,
0.6937718987464905,
0.19643066823482513,
-0.9352019429206848,
-0.31261590123176575,
0.1219065710902214,
-0.27163857221603394,
1.2641136646270752,
0.21173585951328278,
-0.5870015025138855,
-0.656300961971283,
-0.052523571997880936,
-0.33184781670570374,
-0.06624440103769302,
-0.7319079637527466,
-0.7020690441131592,
-0.1585625261068344,
0.25901052355766296,
-0.28694432973861694,
0.28511103987693787,
-0.13867782056331635,
0.45431938767433167,
0.5374694466590881,
-0.3938640058040619,
0.010049658827483654,
-0.41162580251693726,
0.3195396065711975,
0.25606754422187805,
-0.168075293302536,
-0.5736731886863708,
0.03936905041337013,
-0.4580024480819702,
-0.6789441704750061,
-0.11052563786506653,
0.37761226296424866,
-0.05770238861441612,
0.034918028861284256,
0.09334339946508408,
0.3269878923892975,
0.13837823271751404,
-0.80850750207901,
0.4417586922645569,
-0.7312113642692566,
0.5757713317871094,
-0.5738499760627747,
0.26614341139793396,
0.4186078608036041,
-0.11889024823904037,
-0.04773077741265297,
-0.18353474140167236,
-0.37495002150535583,
-0.16011908650398254,
-0.029211604967713356,
-0.10370510816574097,
-0.24202914535999298,
-0.43558138608932495,
-0.33139678835868835,
-0.13072313368320465,
0.20707355439662933,
-0.2251717895269394,
0.038448069244623184,
0.13480396568775177,
-0.21943777799606323,
-0.20683644711971283,
0.644294023513794,
-0.12311291694641113,
-0.3731726408004761,
0.11785292625427246,
0.18266592919826508,
-0.09518138319253922,
0.029383227229118347,
0.22194929420948029,
-0.18801426887512207,
0.5415313839912415,
0.0015451365616172552,
-0.20494386553764343,
-0.3082076609134674,
0.16778621077537537,
0.0332084484398365,
0.5372990369796753,
0.23589524626731873,
-0.1105026826262474,
0.02483413554728031,
0.37271738052368164,
0.16712433099746704,
0.7912723422050476,
-0.1991693526506424,
0.2581985294818878,
-0.5542337894439697,
-0.17584775388240814,
-0.5007177591323853,
-0.7027111649513245,
-0.17172665894031525,
-0.2284599095582962,
-0.13110120594501495,
-0.0871274322271347,
0.5170011520385742,
-0.233308807015419,
0.05494524911046028,
0.08166921138763428,
-0.01588974893093109,
0.1942724734544754,
-0.05406180024147034,
-0.1449187844991684,
0.16825000941753387,
-0.2739335000514984,
-0.3717264235019684,
0.05888044461607933,
0.06627355515956879,
0.1200893372297287,
0.32833853363990784,
-0.5177707672119141,
0.09251286834478378,
-0.5581536889076233,
0.1165756955742836,
-0.28242650628089905,
-0.20633317530155182,
0.1996491402387619,
0.06283187121152878,
0.26434049010276794,
-0.24972812831401825,
-0.27612271904945374,
-0.29741019010543823,
0.11606837064027786,
-0.1992637813091278,
-0.17129264771938324
] |
6,824,558 |
The potential therapeutic role of the enantiomers and metabolites of mianserin.
|
Pinder R M RM, Van Delft A M AM
|
British journal of clinical pharmacology . Vol. 15 Suppl 2, 1983
|
1 S(+)-mianserin is the more potent enantiomer of mianserin in pharmacological tests indicative for antidepressant activity. Pharmacological tests indicative for sedation suggest that sedative effects are similar for mianserin and its enantiomers. 2 Of the three compounds, mianserin had the optimal therapeutic ratio of antidepressant-like activity versus sedative properties when assessed by computerised EEG in healthy volunteers participating in a double-blind placebo-controlled single dose trial. 3 Of the known metabolites, desmethylmianserin and 8-hydroxymianserin substantially retain pharmacological properties indicative for antidepressant activity but are less active than mianserin in tests indicative for sedation. Mianserin-N-oxide is inactive or only weakly active in most pharmacological tests. 4 Desmethylmianserin occurs in human plasma after both single and multiple dosage to an extent of about one-third that of mianserin. 5 Mianserin has optimal efficacy as the racemate. Desmethylmianserin and 8-hydroxymianserin are pharmacologically active metabolites and may contribute to the overall antidepressant effects of mianserin.
|
https://pubmed.ncbi.nlm.nih.gov/6824558/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article"
] |
6824558
|
[
-0.11934296041727066,
0.34648650884628296,
-4.768743991851807,
-3.247925281524658,
0.7772946953773499,
0.5503692030906677,
0.1305941492319107,
2.0326411724090576,
-1.7540466785430908,
-0.5925275683403015,
1.1562684774398804,
2.207145929336548,
-1.6298439502716064,
0.9710886478424072,
1.3475086688995361,
-1.1320905685424805,
0.5753732323646545,
0.29015058279037476,
0.8743883967399597,
-3.029391050338745,
0.2890375852584839,
-1.6640290021896362,
-0.6594229936599731,
0.4288385212421417,
-0.6480978727340698,
-0.9581650495529175,
0.6190731525421143,
0.8243904113769531,
0.4281730055809021,
1.2055445909500122,
-0.8809933662414551,
0.2831227481365204,
0.2946661412715912,
-0.826580822467804,
0.5998286008834839,
-0.5304186940193176,
0.30899176001548767,
0.13172517716884613,
-0.5150653123855591,
-0.2034296840429306,
-0.6883866786956787,
1.3773847818374634,
0.009821594692766666,
-0.017493918538093567,
0.9035237431526184,
0.8847323656082153,
0.6946579813957214,
-0.19772815704345703,
0.20371712744235992,
-0.949900209903717,
-0.30393433570861816,
0.7173891663551331,
-0.6791384220123291,
-1.7611311674118042,
3.381483793258667,
0.9849511981010437,
1.3694185018539429,
0.5288479328155518,
0.7268140912055969,
-0.4310736060142517,
0.000816764950286597,
-1.6437872648239136,
-0.39513906836509705,
0.4813048839569092,
-0.19887836277484894,
-0.4626261293888092,
0.8796152472496033,
-0.18172799050807953,
-1.0473253726959229,
1.1849757432937622,
-0.7334952354431152,
0.4847266376018524,
0.13606134057044983,
0.23219116032123566,
0.68056321144104,
0.8443891406059265,
0.5502894520759583,
0.4215593934059143,
0.8438049554824829,
0.06618043035268784,
-1.2969502210617065,
0.2753361761569977,
-0.5743303894996643,
0.567143440246582,
-0.31675779819488525,
1.1228713989257812,
-0.3992779850959778,
-0.8001016974449158,
0.9792760610580444,
-0.04989130049943924,
0.6640603542327881,
-0.9521713852882385,
-1.0421392917633057,
0.6462789177894592,
-0.09536226838827133,
0.5875440835952759,
-0.2972884178161621,
-0.04436489939689636,
-0.10933738201856613,
-0.5801147818565369,
0.17128145694732666,
-0.14117568731307983,
-0.8654499053955078,
0.15491874516010284,
0.42567914724349976,
0.23907029628753662,
-0.9204570055007935,
-0.3055521547794342,
-0.3854601979255676,
-0.6317681074142456,
-0.5025044679641724,
-0.4911442995071411,
0.23652788996696472,
0.05303943157196045,
0.4473216235637665,
0.6463530659675598,
-0.3983016312122345,
-0.2075984925031662,
-0.37154924869537354,
0.03911152482032776,
0.03213062882423401,
0.9136992692947388,
-0.0985276848077774,
0.7813937664031982,
-0.744177520275116,
0.14659087359905243,
-0.2634219825267792,
-0.3791399896144867,
0.5871061682701111,
-0.5850989818572998,
-0.6951638460159302,
1.0563063621520996,
0.07534612715244293,
0.019839880988001823,
-0.4646795988082886,
-1.069139003753662,
0.3991202414035797,
0.8751526474952698,
0.2733110785484314,
0.6389319896697998,
-0.7444317936897278,
0.774817943572998,
0.008018110878765583,
0.39434611797332764,
-0.5217192769050598,
-0.3065132200717926,
-0.47535187005996704,
0.23534633219242096,
0.3203619718551636,
0.20355165004730225,
-0.11330506950616837,
0.5514036417007446,
0.48106423020362854,
-1.0192451477050781,
0.5336872935295105,
0.5283066630363464,
0.5093274712562561,
-0.16255609691143036,
-0.07889623939990997,
0.05843169614672661,
-0.8072410225868225,
-0.2955276370048523,
0.26228711009025574,
-0.14107532799243927,
-0.15105833113193512,
0.28147342801094055,
-0.4696334898471832,
0.05187196657061577,
0.33303648233413696,
-0.32596829533576965,
-0.5174881815910339,
0.2474440634250641,
0.04326441138982773,
0.6212238073348999,
-0.11223336309194565,
0.14972259104251862,
0.11185378581285477,
-0.10880422592163086,
0.10882991552352905,
1.148398995399475,
-0.4998238980770111,
0.8652102947235107,
-0.48606443405151367,
0.5155068039894104,
0.6263880729675293,
-0.4641159176826477,
-0.17784902453422546,
-0.43591320514678955,
-0.05702446028590202,
0.8993365168571472,
0.30237388610839844,
-0.49858030676841736,
0.13311922550201416,
-0.02672983892261982,
0.1294674575328827,
-0.6627141833305359,
-0.0768757313489914,
-0.06506545096635818,
0.5444126725196838,
-0.5705154538154602,
0.1383303850889206,
0.18991489708423615,
-0.15616177022457123,
0.05029989033937454,
0.37723663449287415,
0.342570036649704,
-0.5541163682937622,
0.33914715051651,
-0.3063705563545227,
0.03261194005608559,
0.12354528903961182,
-0.6258529424667358,
-0.13249793648719788,
0.17891286313533783,
-0.0551021434366703,
-0.023777764290571213,
0.09187672287225723,
1.0505956411361694,
-0.36712533235549927,
-0.05210278555750847,
-0.1640118658542633,
-0.04785778373479843,
-0.2557804584503174,
-0.2500847280025482,
0.0934070348739624,
-0.3551085591316223,
-0.3193984627723694,
0.25185564160346985,
-0.12566480040550232,
-0.23599329590797424,
-0.3648586571216583,
0.059334930032491684,
0.4146033823490143,
-0.27272236347198486,
0.360017329454422,
0.2490888237953186,
0.1648041009902954,
-0.06527063995599747,
0.2977273762226105,
-0.060112062841653824,
0.028680013492703438,
-0.2531919777393341,
-0.15987655520439148,
-0.08016655594110489,
0.029236283153295517,
-0.8222169876098633,
-0.3981924057006836,
0.051504168659448624,
0.44346463680267334,
-0.1782141774892807,
-0.020589640364050865,
-0.13737301528453827,
-0.5440759062767029,
0.38594508171081543,
-0.21666879951953888,
-0.0217970609664917
] |
6,824,608 |
Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte protoporphyrin determinations.
|
Romslo I I, Haram K K, Sagen N N, Augensen K K
|
British journal of obstetrics and gynaecology . Vol. 90, No. 2, 1983 Feb
|
Serum iron, serum iron-binding capacity, serum ferritin and erythrocyte protoporphyrin were determined during uncomplicated pregnancy in 45 healthy women; 22 were given oral iron while the others were given a placebo. When iron was not given, 15 out of 23 women had exhausted iron stores and iron deficiency at term, as judged from low serum ferritin, low serum transferrin saturation and high erythrocyte protoporphyrin values. Only seven of them had a haemoglobin concentration between 10 and 11 g/dl at term but none had values less than 10 g/dl. In the iron-treated group (n = 22) none of the women developed iron deficiency. Serum ferritin was the most sensitive and specific test of iron deficiency. A practical procedure to detect iron deficiency and to control iron supplementation in pregnancy is suggested.
|
https://pubmed.ncbi.nlm.nih.gov/6824608/
|
[
"Clinical Trial",
"Comparative Study",
"Controlled Clinical Trial",
"Journal Article"
] |
6824608
|
[
0.17298391461372375,
0.7171793580055237,
-2.373922109603882,
-2.230194568634033,
0.8711912035942078,
0.776605486869812,
0.1326625645160675,
0.0927252545952797,
-1.91817307472229,
-0.994627833366394,
-1.5562584400177002,
1.2341176271438599,
-0.09156196564435959,
-0.0947466641664505,
0.11089397221803665,
-1.1192710399627686,
-1.9720942974090576,
-0.5802324414253235,
1.3880176544189453,
-3.1638290882110596,
-0.3402926027774811,
0.4054569602012634,
-0.3564526438713074,
0.7110477089881897,
1.042461633682251,
0.5822542309761047,
-0.27365943789482117,
1.4890468120574951,
0.715262770652771,
0.18404659628868103,
0.7544963359832764,
1.006657361984253,
0.02494870126247406,
-0.5799477100372314,
0.14397865533828735,
-0.33129993081092834,
2.8647608757019043,
-0.2693398594856262,
-1.345393180847168,
-0.9702383279800415,
1.0201746225357056,
-0.6307676434516907,
-1.1220917701721191,
-0.3637838661670685,
1.5056817531585693,
-1.090819239616394,
1.5878002643585205,
-1.870090126991272,
-0.8722701072692871,
1.2086021900177002,
0.0891038030385971,
1.0093204975128174,
-1.3417232036590576,
-1.5288190841674805,
1.5321662425994873,
0.026407679542899132,
0.38691258430480957,
0.41441118717193604,
0.44472673535346985,
0.5575645565986633,
1.1753777265548706,
-0.05404941737651825,
-0.22451388835906982,
0.508980929851532,
-1.7312567234039307,
-0.435092568397522,
0.9082365036010742,
-0.7562644481658936,
-1.7437694072723389,
1.9265307188034058,
0.022838590666651726,
-0.7472144961357117,
0.014826842583715916,
0.06448517739772797,
0.8999861478805542,
0.2485290765762329,
-0.9249783158302307,
0.15092889964580536,
-0.035612672567367554,
0.48268669843673706,
-0.08338744193315506,
-0.49985620379447937,
0.09918709844350815,
0.7014691233634949,
0.4070250988006592,
0.7024372816085815,
-0.6959824562072754,
-0.5771940350532532,
1.2030686140060425,
-0.757996678352356,
-0.42191651463508606,
0.01032436452805996,
-1.2109465599060059,
0.9261447787284851,
-0.30713459849357605,
0.3251652121543884,
-0.5698133111000061,
0.8780738711357117,
-0.8700480461120605,
0.10179909318685532,
-0.1569490134716034,
1.1918538808822632,
-0.7195825576782227,
-0.6010820269584656,
-0.40118908882141113,
-0.08513230085372925,
-0.36085373163223267,
-0.5954989194869995,
-0.21894806623458862,
0.01640353724360466,
0.056096360087394714,
-0.00882742740213871,
-0.7962426543235779,
0.7222394943237305,
0.017657170072197914,
1.0241646766662598,
-0.6507635116577148,
-0.23464561998844147,
-0.48278555274009705,
-0.15330807864665985,
0.3030334711074829,
1.0122485160827637,
-0.14968866109848022,
0.3329432010650635,
0.13943085074424744,
0.1169651672244072,
0.5665911436080933,
-0.599207878112793,
-0.8728801012039185,
-0.12759189307689667,
-1.2326362133026123,
0.1451413631439209,
0.14220960438251495,
-0.28802284598350525,
-0.8985710144042969,
0.35361218452453613,
0.27843132615089417,
1.3016586303710938,
0.07471618056297302,
-0.07342000305652618,
-1.451080322265625,
-0.3560469448566437,
-0.5689675807952881,
0.7181607484817505,
-1.6656626462936401,
-0.18014773726463318,
-0.7223139405250549,
-0.32758307456970215,
0.07699229568243027,
-0.006359782535582781,
-0.1746620386838913,
-0.06067836284637451,
0.3628076910972595,
-0.11604148894548416,
0.24585165083408356,
-0.4275546073913574,
-0.17445915937423706,
1.133553147315979,
0.0005171858356334269,
0.1663171947002411,
0.0729638934135437,
0.14619317650794983,
-0.43622878193855286,
-0.12094227969646454,
0.27495262026786804,
-0.25703883171081543,
-0.2275007963180542,
0.6832123398780823,
0.5973450541496277,
0.3424529433250427,
-0.16744184494018555,
0.017655888572335243,
-0.40163731575012207,
0.849038302898407,
0.4822685420513153,
0.18193073570728302,
0.41217708587646484,
-0.10379056632518768,
0.3382136821746826,
-0.10352965444326401,
0.059415847063064575,
-0.42522066831588745,
-0.2672699987888336,
-0.7723197937011719,
-0.3142074942588806,
-0.8244597315788269,
-0.829021155834198,
-0.03382866829633713,
0.10289476066827774,
0.1047038584947586,
-0.01816468872129917,
0.18515758216381073,
-0.6874492168426514,
0.23905819654464722,
0.06886706501245499,
-0.3520512878894806,
0.36927229166030884,
0.22680997848510742,
0.5375712513923645,
0.2768760621547699,
0.39355477690696716,
-0.18928015232086182,
-0.024272028356790543,
-0.014392172917723656,
0.122390978038311,
0.539182186126709,
0.3292810320854187,
0.10593217611312866,
-0.12287338823080063,
0.017590638250112534,
0.22508810460567474,
0.08674470335245132,
-0.04353540018200874,
-0.03928685933351517,
0.43775373697280884,
-0.21531520783901215,
0.6768335103988647,
-0.06317531317472458,
-0.33817481994628906,
-0.5014489889144897,
0.12050381302833557,
-0.42729058861732483,
-0.6515401005744934,
-0.15647561848163605,
0.3838466703891754,
-0.321737140417099,
-0.06746470183134079,
0.2734338343143463,
-0.13252554833889008,
0.030572544783353806,
0.0808960422873497,
0.11089185625314713,
-0.4462822675704956,
-0.2529084384441376,
0.03241021931171417,
-0.09951768815517426,
-0.18124963343143463,
0.3492240011692047,
-0.12401598691940308,
-0.1720522940158844,
0.3316422700881958,
-0.5558764934539795,
0.09292879700660706,
-0.05711320415139198,
-0.5898332595825195,
-0.216609388589859,
0.3280000388622284,
0.35045474767684937,
0.36643335223197937,
-0.9019618630409241,
-0.038130730390548706,
0.07861551642417908,
-0.13637876510620117,
-0.07249127328395844,
0.020585911348462105,
0.07767052203416824
] |
6,824,894 |
Final inline filtration for intravenous infusions: a prospective hospital study.
|
Allcutt D A DA, Lort D D, McCollum C N CN
|
The British journal of surgery . Vol. 70, No. 2, 1983 Feb
|
Phlebitis is the most common complication of intravenous therapy affecting more than 50 per cent of infusions. Particles in or added to infusions have been implicated, hence a filter with pore size of 0.2 micron containing both hydrophobic and hydrophilic elements (Pall Biomedical) has been evaluated. All infusions of likely duration greater than 48 h, set up in a 2-month period at this hospital, were randomized to filter or identical dummy. The endpoints and statistical power of the study were determined at the outset. Of the 226 infusions randomized, 32 failed within 24 h and were excluded leaving 194 of whom 93 had dummy and 101 filter. Only 38 infusions with dummy survived until no longer required compared to 63 infusions with filter (chi 2 = 7.68, P less than 0.01). Analysed by life table, the trend for filtered infusions to survive longer failed to achieve statistical significance, but inline filtration prolonged the phlebitis-free survival of infusions (P less than 0.01). These benefits were most marked in the 49 infusions where antibiotics were administered via the drip site. Inline filtration delays the onset of phlebitis, thus more infusions survive until they are no longer required. This effect is not sufficiently strong to institute an overall hospital policy but filters may be indicated in patients requiring intravenous antibiotics.
|
https://pubmed.ncbi.nlm.nih.gov/6824894/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6824894
|
[
-1.7182010412216187,
2.846564292907715,
-1.6795896291732788,
-2.3410701751708984,
0.6262898445129395,
0.5707252025604248,
0.9747921824455261,
-0.601672351360321,
-0.27929866313934326,
0.3994109630584717,
-0.35275596380233765,
0.8092807531356812,
-0.24739521741867065,
0.35200023651123047,
0.1254044771194458,
-1.0170856714248657,
-1.5502699613571167,
-0.5445165038108826,
1.034558653831482,
-1.7630362510681152,
0.6693278551101685,
0.9232671856880188,
0.31488141417503357,
0.7012438178062439,
0.49958908557891846,
-0.39562979340553284,
0.7332400679588318,
-0.15801967680454254,
0.25491008162498474,
0.3342372179031372,
0.5513851046562195,
0.2696954607963562,
0.32249096035957336,
-0.0558173842728138,
0.46547698974609375,
-0.47689762711524963,
1.0237351655960083,
1.2078624963760376,
-0.31778091192245483,
-0.4983617961406708,
0.680752158164978,
1.4107885360717773,
-0.34042903780937195,
-0.3141050636768341,
0.7616937160491943,
-0.4385967254638672,
0.8006719350814819,
-0.7868386507034302,
-0.23327608406543732,
0.7225238084793091,
-0.11036783456802368,
1.1601371765136719,
-0.5955987572669983,
0.3088761866092682,
0.7993822693824768,
-0.038520533591508865,
0.2504625916481018,
0.10854196548461914,
0.315628319978714,
-0.29121288657188416,
0.6531927585601807,
-0.3860616981983185,
0.14872990548610687,
0.1060650646686554,
-0.5138011574745178,
-0.24027638137340546,
0.3533237874507904,
0.39754727482795715,
-0.264440655708313,
0.6542496681213379,
-0.6977288722991943,
-0.1638658344745636,
0.25371143221855164,
0.7748360633850098,
0.6449911594390869,
0.7408413290977478,
-0.44559165835380554,
0.9403738975524902,
-0.22744427621364594,
0.4347113370895386,
-0.38961857557296753,
-0.378914475440979,
-0.05839989334344864,
0.11181376874446869,
-0.12026041746139526,
0.20809592306613922,
0.04001409187912941,
-0.6548221707344055,
0.40050339698791504,
-0.5773078203201294,
0.34597015380859375,
-0.16529713571071625,
-1.1716411113739014,
0.39870309829711914,
-0.5547800064086914,
0.12796306610107422,
-0.22642044723033905,
0.28707078099250793,
-0.3207094967365265,
-0.25413885712623596,
-0.3930094242095947,
-0.33346885442733765,
-0.45136696100234985,
-0.15013931691646576,
-0.1042177751660347,
-0.46062949299812317,
0.13246896862983704,
-0.09711349755525589,
-0.4507443308830261,
-0.08639871329069138,
0.006939534097909927,
-0.5723675489425659,
-0.041016578674316406,
-0.2557585835456848,
-0.06404965370893478,
0.07086978852748871,
0.3440264165401459,
-0.47887682914733887,
0.29278552532196045,
-0.7533982396125793,
-0.1433809995651245,
0.4011881947517395,
0.09179488569498062,
0.009616786614060402,
-0.2172311395406723,
0.32991406321525574,
-0.07797983288764954,
0.9786567091941833,
-0.46338775753974915,
-0.14796994626522064,
-0.6436973810195923,
-0.24395723640918732,
0.09129226207733154,
-0.5089982748031616,
-0.7083336114883423,
-0.3486255705356598,
0.30911412835121155,
0.4530237019062042,
0.2929329574108124,
-0.9974873661994934,
0.43179836869239807,
0.23376689851284027,
-0.3024708926677704,
0.06371529400348663,
-0.2930843234062195,
-0.28685155510902405,
-0.8752861618995667,
0.11379069834947586,
-0.23910383880138397,
-0.03822988271713257,
-0.3331753611564636,
0.7521211504936218,
0.32268616557121277,
-0.05140771344304085,
-0.07368046790361404,
0.49612799286842346,
0.05238964781165123,
0.499901682138443,
-0.08102775365114212,
0.1796177178621292,
0.1451893001794815,
-0.2280370444059372,
-0.13012053072452545,
-0.2654949128627777,
0.7885684370994568,
0.16628019511699677,
0.045458074659109116,
0.36655953526496887,
-0.08057694882154465,
0.026307931169867516,
-0.605676531791687,
0.02325805090367794,
-0.10488837212324142,
0.2654227316379547,
-0.16197222471237183,
-0.6231032013893127,
0.22184713184833527,
0.33916276693344116,
-0.10048924386501312,
0.20003579556941986,
0.3225049376487732,
-0.511258065700531,
0.2741089165210724,
0.36029186844825745,
-0.2856364846229553,
-0.005221422761678696,
-0.17453359067440033,
-0.6134256720542908,
-0.019212594255805016,
-0.1759476214647293,
0.47149550914764404,
0.011530276387929916,
0.005751762539148331,
0.14396420121192932,
0.5151607394218445,
0.16548410058021545,
0.09796067327260971,
0.4577544629573822,
0.623958945274353,
-0.24691660702228546,
0.01832200214266777,
0.28354454040527344,
-0.04006509855389595,
0.3927575647830963,
0.0847892016172409,
0.22191151976585388,
-0.018499864265322685,
0.4139474928379059,
-0.43153321743011475,
0.740832507610321,
0.26048439741134644,
0.1284620463848114,
0.37594717741012573,
-0.01605493202805519,
0.03530457615852356,
-0.24054904282093048,
0.2228928804397583,
-0.029235191643238068,
-0.32597294449806213,
-0.0010538609931245446,
0.12231310456991196,
-0.34119102358818054,
-0.10114660114049911,
0.11271394789218903,
-0.31037116050720215,
-0.4953814744949341,
0.09901899099349976,
0.1238374263048172,
0.2352139800786972,
-0.7062873840332031,
0.015595974400639534,
0.027643997222185135,
-0.05229867249727249,
0.07368101924657822,
0.032140813767910004,
-0.27060970664024353,
0.12375710159540176,
-0.02701973170042038,
-0.30280181765556335,
0.10195174068212509,
-0.22845742106437683,
-0.5317989587783813,
-0.21768443286418915,
-0.35799482464790344,
-0.16954351961612701,
0.1242477223277092,
0.011511275544762611,
-0.011826818808913231,
0.4059317409992218,
-0.3114337623119354,
0.21644511818885803,
-0.07325506955385208,
-0.20567090809345245,
0.044865742325782776,
0.05305876210331917,
0.15187399089336395
] |
6,824,898 |
Attenuation of adrenocortical response to upper abdominal surgery with epidural blockade.
|
Tsuji H H, Asoh T T, Takeuchi Y Y, Shirasaka C C
|
The British journal of surgery . Vol. 70, No. 2, 1983 Feb
|
Plasma cortisol concentrations and urinary 17-OHCS excretion were measured in two groups of 15 patients receiving elective gastrectomy under either general anaesthesia or epidural blockade. In another 15 patients receiving epidural blockade, the vagus nerve was blocked by injection of local anaesthetics or by truncal vagotomy, and their cortisol response to gastrectomy was compared with the other two groups. Gastrectomy under general anaesthesia caused a marked increase in plasma cortisol concentrations and in urinary excretion of 17-OHCS. These adrenocortical responses to gastrectomy were significantly inhibited in patients operated upon under epidural blockade extending from T3-4 to L1-2 and continuing for 48 h postoperatively. In patients receiving both epidural and vagus nerve blockade, the plasma cortisol response was the same as in those receiving epidural blockade alone. The results indicated that the adrenocortical response to upper abdominal surgery was safely attenuated, though not abolished, with high spinal epidural blockade continuing for 48 h postoperatively. The vagus nerve was not likely to be playing an important role in the adrenocortical response to gastrectomy.
|
https://pubmed.ncbi.nlm.nih.gov/6824898/
|
[
"Clinical Trial",
"Comparative Study",
"Journal Article",
"Randomized Controlled Trial"
] |
6824898
|
[
-0.2111375480890274,
1.8961296081542969,
-1.5833967924118042,
-1.8364450931549072,
1.5773954391479492,
-0.3492687940597534,
0.9185839295387268,
1.6759541034698486,
-3.046964406967163,
0.7278144955635071,
0.9152207374572754,
1.1192479133605957,
0.09852422773838043,
0.6369311809539795,
0.8414472937583923,
1.3360072374343872,
0.22111378610134125,
0.45141616463661194,
0.5395587682723999,
-1.7367031574249268,
1.855089545249939,
-0.11597944796085358,
-1.286541223526001,
-0.9260483980178833,
1.0256929397583008,
-0.07229196280241013,
0.23440182209014893,
-0.8604534268379211,
0.36181819438934326,
-0.2736281454563141,
-0.12089351564645767,
-0.38855913281440735,
0.11749105155467987,
1.0157983303070068,
-0.4412274658679962,
0.04577336460351944,
1.489309549331665,
0.15098819136619568,
-0.11793647706508636,
-0.2470535933971405,
1.2490681409835815,
-0.15210981667041779,
0.5097426772117615,
-0.5850564241409302,
2.23142671585083,
-0.038142129778862,
0.608369767665863,
0.06516837328672409,
1.7242815494537354,
-1.1112992763519287,
-0.8998145461082458,
-0.43379420042037964,
-0.47173166275024414,
-0.35764575004577637,
1.1852290630340576,
1.3820668458938599,
0.5562279224395752,
0.9203904867172241,
0.6742444038391113,
-0.24895189702510834,
-0.5017704963684082,
1.5612566471099854,
-0.27988630533218384,
-1.0469974279403687,
-0.985884428024292,
-0.4638577401638031,
0.12538336217403412,
-0.060130346566438675,
-0.06695404648780823,
0.011027702130377293,
-1.654457688331604,
1.0034185647964478,
0.6609809398651123,
-0.2657831311225891,
1.1358343362808228,
0.6659738421440125,
-0.634065568447113,
-0.3720799684524536,
1.3216718435287476,
0.2132188081741333,
-0.6330704689025879,
-0.23815998435020447,
-1.161145806312561,
0.9530967473983765,
-0.37150442600250244,
0.48702186346054077,
-2.196948766708374,
-0.39077383279800415,
0.2626909613609314,
-0.9414569139480591,
0.43113967776298523,
-0.9620673060417175,
-1.3486746549606323,
-0.110917828977108,
-0.0928042083978653,
0.7628564834594727,
0.01914720982313156,
0.20814761519432068,
-1.0068814754486084,
-0.18506240844726562,
0.9344667196273804,
-0.33948320150375366,
0.008489255793392658,
0.05401328206062317,
-0.9573569893836975,
-0.15765024721622467,
0.25588417053222656,
-0.0856749638915062,
-0.8217847347259521,
-1.2753843069076538,
0.8881055116653442,
-1.1823900938034058,
0.16237212717533112,
-0.7209519147872925,
-0.205665722489357,
0.4894244968891144,
-0.597732663154602,
-0.14718006551265717,
0.39533570408821106,
-0.11554443836212158,
-0.44474703073501587,
0.7060897350311279,
-0.7497740387916565,
0.6767770051956177,
-0.41760680079460144,
-0.4008907973766327,
-0.18080976605415344,
0.07659634202718735,
-0.17015355825424194,
-0.13849249482154846,
-0.6290900111198425,
0.9668591618537903,
0.4293587803840637,
-0.11808941513299942,
-1.5054904222488403,
-0.36686089634895325,
0.8343797326087952,
0.32604068517684937,
0.21247431635856628,
-0.3173357844352722,
0.30962786078453064,
0.22359129786491394,
-0.6052885055541992,
-0.15164722502231598,
-0.960397481918335,
-0.4357794523239136,
0.03124038316309452,
-0.1147027462720871,
-0.49572569131851196,
0.3129379153251648,
0.11178604513406754,
0.08983220160007477,
0.8971717953681946,
0.5597359538078308,
0.13860392570495605,
-0.34955087304115295,
0.024144986644387245,
0.5228801965713501,
0.025861959904432297,
-0.7727333307266235,
-0.397799551486969,
0.4079059660434723,
0.3354671001434326,
-0.5234454274177551,
0.055730435997247696,
-0.7201232314109802,
-0.7584646344184875,
0.7008263468742371,
0.30649879574775696,
0.6519467234611511,
-0.7627168893814087,
-0.26183247566223145,
0.4322439432144165,
0.27693167328834534,
-0.08920329809188843,
0.1245589628815651,
0.030059346929192543,
0.11540834605693817,
0.5811529755592346,
-0.6815975308418274,
-0.12294057756662369,
-0.15425816178321838,
0.2242838591337204,
-0.18576212227344513,
-0.10498618334531784,
0.20496240258216858,
0.42364591360092163,
-0.9283603429794312,
-0.5843737125396729,
0.3382372260093689,
-0.08786167949438095,
0.20841428637504578,
-0.668035626411438,
-0.5430006980895996,
0.42068248987197876,
0.18229708075523376,
-0.5331950783729553,
0.3768754303455353,
0.759498655796051,
-0.6049836277961731,
0.7509915828704834,
-0.006458867806941271,
-0.2583346366882324,
0.4407568871974945,
0.21952258050441742,
-0.10584311932325363,
0.2611701488494873,
0.2957914471626282,
-0.4873242974281311,
0.26237261295318604,
0.1864628791809082,
-0.15616492927074432,
0.4175281524658203,
0.5907397270202637,
-0.23067250847816467,
0.6265500783920288,
-0.14979620277881622,
0.27917617559432983,
-0.7831847071647644,
-0.3024751842021942,
0.41539400815963745,
-0.10954712331295013,
0.3286098837852478,
0.3249778747558594,
-0.2736216187477112,
0.017564693465828896,
-0.34253865480422974,
0.12326750159263611,
0.01275630109012127,
-0.31836608052253723,
-0.1494840532541275,
0.2752005159854889,
0.15362566709518433,
-0.43706372380256653,
0.08237353712320328,
0.1716187447309494,
0.5219675302505493,
-0.35362523794174194,
0.40182653069496155,
0.37087297439575195,
0.04378035292029381,
-0.4162437617778778,
0.013413908891379833,
-0.1959204077720642,
0.19571428000926971,
-0.04262630268931389,
0.2388134002685547,
0.37972545623779297,
0.3923673629760742,
-0.12031253427267075,
0.18169662356376648,
-0.08292073011398315,
0.272222101688385,
-0.003675302257761359,
0.3940160274505615,
0.250379353761673
] |
6,824,996 |
Preventing acetylsalicylic acid damage to human gastric mucosa by use of prostaglandin E2.
|
Cohen M M MM, Clark L L
|
Canadian journal of surgery. Journal canadien de chirurgie . Vol. 26, No. 2, 1983 Mar
|
To determine the lowest dose of prostaglandin E2 (PGE2) capable of preventing the acetylsalicylic acid (ASA)-induced fall in the gastric transmucosal potential difference, six healthy men (mean age 24 years) were studied on 5 separate days, in random sequence. In the control experiment, 100 ml of 140 mM hydrochloric acid was instilled five times into the stomach for 15 minutes each time, during which the transmucosal potential difference was measured continuously. In the test experiments, 20 mM ASA plus PGE2 in doses of 0, 0.1, 0.5, or 1.0 mg were added to the control solution during the second and third instillations. The mean control potential difference (+/- standard error) was -50 +/- 2 mV. During the administration of ASA there was a 25% reduction in the potential difference; this change was statistically significant (p less than 0.01). With all three doses of PGE2 the fall in potential difference was prevented. The results demonstrate that ASA damage to human gastric mucosa can be prevented entirely by concurrent administration of as little as 100 micrograms of PGE2. This supports the view that mucosal protection is a physiologic function of PGE2.
|
https://pubmed.ncbi.nlm.nih.gov/6824996/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6824996
|
[
0.2276057004928589,
1.7220169305801392,
-2.1941637992858887,
-3.1465256214141846,
0.979035496711731,
0.6570760607719421,
0.888460099697113,
-0.8788970708847046,
-0.2520477771759033,
-0.8343586325645447,
-0.19445031881332397,
0.7020224332809448,
-0.581493616104126,
0.06723922491073608,
-0.9151888489723206,
0.014396991580724716,
-0.8095739483833313,
0.5722604393959045,
0.042115360498428345,
-1.018919587135315,
0.7139862775802612,
0.4518055319786072,
-1.035470962524414,
-0.4812621474266052,
0.11361081153154373,
-0.5008573532104492,
0.6249927878379822,
0.11458483338356018,
0.20371711254119873,
1.1693934202194214,
0.4172614812850952,
0.25446808338165283,
1.0632799863815308,
0.025958731770515442,
0.2915041446685791,
-0.06713797152042389,
0.3128575384616852,
0.12135613709688187,
0.20328684151172638,
-0.746694803237915,
0.16951660811901093,
0.44811975955963135,
0.9426508545875549,
-1.201552152633667,
1.038994312286377,
-0.2857658863067627,
0.49900415539741516,
0.2863944470882416,
0.3771151602268219,
0.35025814175605774,
0.5308372974395752,
0.2881776690483093,
-0.6176804900169373,
0.1839795559644699,
1.71644926071167,
0.36197108030319214,
0.5787895321846008,
0.08877868950366974,
1.1763824224472046,
-0.22527705132961273,
-0.3823392391204834,
0.5365920066833496,
0.2581636309623718,
0.12685316801071167,
0.31823477149009705,
-0.4853059649467468,
0.6586201190948486,
0.7336574792861938,
-0.16736707091331482,
0.928076446056366,
-0.2084229290485382,
0.21383948624134064,
0.86736661195755,
-0.7066541910171509,
0.5432233810424805,
0.9362865686416626,
0.4908144176006317,
0.8671130537986755,
0.6027798652648926,
0.289562463760376,
-0.6757304072380066,
0.009727015160024166,
-0.3140227198600769,
0.08290712535381317,
0.10687307268381119,
0.7588876485824585,
-0.4351276457309723,
-0.731574535369873,
0.5234879851341248,
-0.5290990471839905,
0.336794912815094,
-0.46928900480270386,
-1.445491909980774,
0.0595158189535141,
0.11301888525485992,
-0.28862935304641724,
0.41864317655563354,
0.1321018487215042,
-0.3176145553588867,
-0.21245327591896057,
0.25699132680892944,
-0.409077912569046,
-0.4057811498641968,
0.42793914675712585,
-0.12262100726366043,
-0.40731850266456604,
-0.37088650465011597,
-0.03725748509168625,
-0.2660866975784302,
-0.40449729561805725,
-0.287320613861084,
-0.33114147186279297,
-0.4600569009780884,
-0.41711074113845825,
-0.012368340976536274,
0.4435398578643799,
-0.031184878200292587,
0.08059883862733841,
-0.33778682351112366,
-0.4251194894313812,
-0.08321451395750046,
0.5794903039932251,
0.12024393677711487,
0.48852598667144775,
0.24227941036224365,
-0.13596484065055847,
-0.15375712513923645,
0.21248024702072144,
-0.095923513174057,
-0.31996437907218933,
-0.7222214937210083,
0.13049137592315674,
0.29792580008506775,
-0.48238927125930786,
-0.4189121127128601,
-0.26804861426353455,
0.4041731059551239,
0.423385351896286,
0.7517598867416382,
0.003334705252200365,
0.06411411613225937,
-0.019640421494841576,
-0.5146893262863159,
0.1858150064945221,
-0.9654210209846497,
-0.418608695268631,
-0.32606592774391174,
0.5218456387519836,
-0.5820862650871277,
0.3328663408756256,
-0.13016144931316376,
-0.25748932361602783,
0.5102649331092834,
-0.4028756618499756,
-0.46107450127601624,
0.22533094882965088,
0.16383101046085358,
-0.04555799439549446,
0.18949487805366516,
-0.0008692308911122382,
0.3076900541782379,
-0.2780541479587555,
-0.34427133202552795,
-0.2974632978439331,
0.2964511811733246,
0.10021793097257614,
0.08659090846776962,
-0.09139394760131836,
-0.02417736127972603,
-0.4481606185436249,
-0.5279191732406616,
0.3729858696460724,
0.2602776288986206,
0.36536580324172974,
0.2665405869483948,
-0.11677283048629761,
0.20928794145584106,
-0.20419356226921082,
0.3280523717403412,
0.5304509997367859,
-0.04744754359126091,
0.09478457272052765,
0.17002460360527039,
-0.002143742050975561,
0.20171205699443817,
-0.37741750478744507,
-0.19016802310943604,
-0.32076895236968994,
-0.08964892476797104,
0.6338443756103516,
0.381358802318573,
0.037561994045972824,
-0.252768874168396,
-0.21282647550106049,
0.25459542870521545,
0.16655725240707397,
-0.14596423506736755,
0.335712194442749,
0.41083472967147827,
0.2636510729789734,
0.7167451977729797,
0.2329663783311844,
0.00073344970587641,
0.33814096450805664,
0.039897266775369644,
-0.034923847764730453,
-0.2588418424129486,
0.2212478071451187,
0.02765715681016445,
-0.25437629222869873,
0.3062437176704407,
-0.014458388090133667,
-0.007304128725081682,
0.3703148365020752,
0.16349707543849945,
0.09017922729253769,
-0.2307514250278473,
-0.15111170709133148,
-0.29056158661842346,
-0.04560248553752899,
-0.07938521355390549,
0.18748623132705688,
-0.357787549495697,
-0.07343888282775879,
0.22322680056095123,
-0.05917411297559738,
-0.2856580317020416,
0.10050249844789505,
0.10672327131032944,
-0.22834329307079315,
-0.34628263115882874,
-0.2158861607313156,
-0.2794296443462372,
-0.0702081173658371,
0.029496995732188225,
0.0646178349852562,
-0.07559593766927719,
0.12335828691720963,
0.04270899295806885,
-0.34295207262039185,
0.1789199411869049,
-0.7352023720741272,
-0.27956750988960266,
0.10688124597072601,
0.20286840200424194,
-0.17173343896865845,
-0.12164556235074997,
0.26315194368362427,
-0.11004603654146194,
0.39815935492515564,
0.4592984616756439,
-0.10718533396720886,
0.012486287392675877,
0.6491437554359436,
0.14602896571159363,
-0.14373213052749634
] |
6,824,997 |
Randomized trial of elective highly selective or truncal vagotomy in chronic duodenal ulceration.
|
Elder J B JB, Ganguli P C PC, Koffman C C CC, Hay D J DJ, Gillespie I E IE, Mantoudis S M SM, Tweedle D E DE, Schofield P F PF, Palmer M M
|
Canadian journal of surgery. Journal canadien de chirurgie . Vol. 26, No. 2, 1983 Mar
|
Between 1973 and 1976, 153 patients (124 men, 29 women) with uncomplicated, chronic, duodenal ulcer were entered into a prospective randomized trial of highly selective vagotomy (HSV) or truncal vagotomy and pyloroplasty (TVP). The study was conducted in four Manchester hospitals and the operations were performed by consultants or chief registrars. The follow-up was conducted by personal interview using a standardized questionnaire. The medical gastroenterologist did not know which type of operation the patient had had. The patients who had symptoms were referred back to the surgeon who performed the operation. The clinical laboratory and follow-up data were analysed by computer. There were no operative deaths. Three patients died from unrelated causes, 13 were lost to follow-up; 137 (89.5%) were followed up for a mean of 4.1 years (range from 2.5 to 5.5 years). A modified Visick grading was used to assess the results of surgery. The outcome was good in 82% after TVP and 73% after HSV. This difference and those in the incidences of early or late postprandial dumping, bilious vomiting, weight loss, anemia and heartburn were not significant. Diarrhea was more frequent after TVP (13.4%) than after HSV (1.4%); although the difference was significant (p less than 0.025), this complaint did not present a serious clinical problem. Ulcers recurred in 15 (21.4%) patients following HSV and in 5 (7.5%) after TVP; this difference was statistically significant (p less than 0.05).
|
https://pubmed.ncbi.nlm.nih.gov/6824997/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6824997
|
[
-0.39054495096206665,
1.7921353578567505,
-0.651003360748291,
-0.33932849764823914,
0.9827959537506104,
1.2459497451782227,
0.9350133538246155,
-0.28166988492012024,
-0.43252265453338623,
0.25032752752304077,
-0.7945679426193237,
1.337129831314087,
0.11011247336864471,
0.15699009597301483,
-0.41607865691185,
0.046769287437200546,
0.38067322969436646,
0.12815256416797638,
0.37516161799430847,
-1.1807039976119995,
0.06864195317029953,
0.3295430839061737,
-0.12878549098968506,
0.11285819113254547,
0.6345863342285156,
-0.8787144422531128,
-0.10286732763051987,
0.508311927318573,
-0.5847147703170776,
1.1751145124435425,
0.44400542974472046,
-0.12576822936534882,
0.3222687542438507,
0.4776665270328522,
0.48664557933807373,
-0.11323786526918411,
0.5355671644210815,
0.2239915132522583,
-0.013287079520523548,
-0.1333596557378769,
0.9359108209609985,
-0.10569324344396591,
-0.011259078048169613,
-0.3905910551548004,
1.6944202184677124,
-0.23729576170444489,
0.6049478054046631,
0.07788822054862976,
0.3957480788230896,
-0.038943689316511154,
-0.8871892094612122,
0.1931237280368805,
-1.0838918685913086,
0.21955743432044983,
0.9190824031829834,
1.102996826171875,
0.16997376084327698,
0.5824705362319946,
1.3357853889465332,
-0.6613484621047974,
0.7703193426132202,
0.39373746514320374,
0.22215959429740906,
-0.2879907488822937,
-0.3551863431930542,
-0.3346233069896698,
0.146831676363945,
0.19574281573295593,
-0.3800410330295563,
0.5980738997459412,
-0.42326706647872925,
-0.029774950817227364,
0.13455364108085632,
0.27584177255630493,
0.5153377652168274,
0.2137264907360077,
-0.5281171798706055,
0.7418370246887207,
0.09732083976268768,
-0.14919926226139069,
0.18652841448783875,
-0.44994494318962097,
-0.99421226978302,
0.2429804801940918,
-0.07869549840688705,
-0.15048730373382568,
-0.9536431431770325,
-0.5463955998420715,
0.6300265192985535,
-0.879481315612793,
0.019474782049655914,
-0.31640517711639404,
-1.000719666481018,
0.4290715456008911,
-0.1986720860004425,
0.5729609131813049,
0.37695786356925964,
0.001103984541259706,
-0.9594345092773438,
-0.05458644777536392,
0.5009185075759888,
-0.0661335363984108,
0.15465983748435974,
-0.030213886871933937,
-0.5701870322227478,
-0.7248272895812988,
-0.6584895253181458,
-0.4518407881259918,
-0.6037726998329163,
-0.19546523690223694,
0.9052814841270447,
-0.6247414350509644,
0.05699007585644722,
-0.4857162833213806,
-0.05249466001987457,
0.2749940752983093,
0.6797095537185669,
0.22362260520458221,
0.2741657793521881,
-0.14160403609275818,
0.04211290553212166,
0.368764728307724,
0.12837713956832886,
0.4119950830936432,
-0.07274991273880005,
0.0825912207365036,
0.03968413546681404,
0.23712478578090668,
-0.6171730160713196,
-0.1256607472896576,
-0.6929789781570435,
-0.3114861845970154,
0.15585587918758392,
-0.6250088214874268,
-0.3875085413455963,
-0.16134175658226013,
-0.3391568660736084,
1.2495449781417847,
-0.2898623049259186,
-0.2100232094526291,
0.33057689666748047,
0.12551701068878174,
-0.36970019340515137,
-0.0639568418264389,
-0.9395527839660645,
-0.11802250146865845,
-0.20331214368343353,
-0.2339128851890564,
-0.7303221225738525,
-0.023804938420653343,
-0.020709669217467308,
0.10769126564264297,
0.2862716317176819,
-0.16727860271930695,
-0.08967197686433792,
-0.10659574717283249,
0.16814018785953522,
0.201548770070076,
0.03910044580698013,
0.10909198224544525,
0.06483280658721924,
-0.3139854371547699,
-0.12416251003742218,
-0.3968431055545807,
0.11624912917613983,
-0.40191352367401123,
-0.07667575776576996,
-0.22065110504627228,
0.21367643773555756,
-0.06339770555496216,
-0.2705294191837311,
0.03307759389281273,
-0.07046817243099213,
0.41040748357772827,
-0.044726260006427765,
-0.05130050703883171,
0.3467729687690735,
0.2942807376384735,
0.4982021749019623,
-0.43665048480033875,
-0.10645120590925217,
-0.18072713911533356,
0.2535211145877838,
0.0066583720035851,
-0.49107787013053894,
0.06453641504049301,
0.26048675179481506,
-0.4645024836063385,
0.10657884925603867,
0.1265043020248413,
-0.3421099781990051,
0.1099386140704155,
-0.11798480153083801,
-0.0533585324883461,
0.5179462432861328,
0.2641187608242035,
-0.11750075221061707,
-0.48772111535072327,
0.2589126229286194,
0.06312105804681778,
0.2270263433456421,
0.06571348756551743,
0.10327247530221939,
0.2936573326587677,
0.19611668586730957,
-0.055945999920368195,
0.158248633146286,
0.33190450072288513,
-0.429012268781662,
0.028411613777279854,
0.3482770025730133,
-0.2649644911289215,
-0.0726897269487381,
0.19863155484199524,
0.08464176952838898,
0.174275204539299,
0.3452474772930145,
-0.20761756598949432,
-0.6338801383972168,
-0.17570826411247253,
0.20158198475837708,
-0.1194029226899147,
0.2552618682384491,
-0.08575320988893509,
-0.24565128982067108,
-0.09506519138813019,
-0.04166999086737633,
0.0350322499871254,
0.17447061836719513,
-0.04413522034883499,
-0.25687268376350403,
-0.08118853718042374,
-0.0247516967356205,
-0.0936586782336235,
-0.06933722645044327,
-0.2086271494626999,
-0.1036897823214531,
0.07283907383680344,
0.11636598408222198,
0.2509237229824066,
-0.2635135054588318,
-0.27057209610939026,
-0.08777153491973877,
-0.21857072412967682,
-0.04821699112653732,
0.23680146038532257,
0.18530775606632233,
0.35965362191200256,
-0.006814361549913883,
-0.24968324601650238,
0.16476501524448395,
-0.016375640407204628,
0.15695159137248993,
0.12544995546340942,
0.12636969983577728,
-0.028200862929224968
] |
6,825,123 |
Phase I study of tricyclic nucleoside phosphate.
|
Mittelman A A, Casper E S ES, Godwin T A TA, Cassidy C C, Young C W CW
|
Cancer treatment reports . Vol. 67, No. 2, 1983 Feb
|
A phase I study of tricyclic nucleoside phosphate was conducted in 20 adults with advanced cancer. Tricyclic nucleoside phosphate was given as an iv infusion over 15 minutes once every 3 weeks; the doses ranged from 25 to 350 mg/m2. Beginning at a dose of 250 mg/m2, hyperglycemia and elevation of hepatocellular enzymes were observed; at a dose of 350 mg/m2, two patients developed irreversible liver damage. Patients at all dose levels experienced reduction in serum phosphorus; reduction of serum calcium was noted only with the two highest doses. Nausea and vomiting occurred occasionally. Myelosuppression was not a prominent toxic effect. No major therapeutic responses were noted. Further clinical trials employing this schedule are probably not warranted.
|
https://pubmed.ncbi.nlm.nih.gov/6825123/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't",
"Research Support, U.S. Gov't, P.H.S."
] |
6825123
|
[
0.28514179587364197,
2.185413122177124,
-1.4856115579605103,
-2.379730701446533,
0.23747411370277405,
0.9754475951194763,
-0.5580657124519348,
-0.48349735140800476,
-0.8969020247459412,
0.016163557767868042,
-1.0037347078323364,
2.2585225105285645,
-0.529511034488678,
1.110429286956787,
0.18344376981258392,
-0.8584138751029968,
-1.6204150915145874,
0.4656948447227478,
0.9001299142837524,
-2.8313748836517334,
0.4866301715373993,
-1.1045646667480469,
-0.18026818335056305,
1.43585205078125,
0.9860239028930664,
-2.127678394317627,
-0.10550577193498611,
1.9995280504226685,
1.4065392017364502,
1.6423060894012451,
0.1701216846704483,
-0.1632760912179947,
0.9706611633300781,
1.0213497877120972,
0.5138922929763794,
-0.28894832730293274,
1.4188083410263062,
0.4720451533794403,
0.4175150394439697,
-0.1187843456864357,
0.6344165802001953,
-0.32026416063308716,
0.09482504427433014,
-0.05561738461256027,
1.1774858236312866,
0.26885008811950684,
0.6989977359771729,
-0.6396229863166809,
0.5478003025054932,
0.7306919097900391,
-0.29699379205703735,
1.0420165061950684,
-1.7461036443710327,
0.24088627099990845,
1.110517978668213,
-0.13238729536533356,
0.4077683985233307,
-0.1582004278898239,
1.8145443201065063,
-0.13596537709236145,
0.32090309262275696,
1.2427412271499634,
-0.5659894943237305,
-0.38024336099624634,
0.3015272617340088,
0.7758885622024536,
0.9581193923950195,
0.0754094272851944,
-1.1402268409729004,
0.5894800424575806,
-0.12586893141269684,
0.4801868796348572,
0.07193046808242798,
-0.13810791075229645,
1.1942377090454102,
1.093949317932129,
-0.1060079038143158,
0.3962225914001465,
-0.29347383975982666,
0.15953896939754486,
-1.3866490125656128,
-0.04474135860800743,
-0.09941138327121735,
1.1786918640136719,
-0.4202750027179718,
0.66070556640625,
-0.7198876142501831,
-0.6398780941963196,
0.1816241443157196,
-1.2383733987808228,
0.7166624069213867,
-1.5387296676635742,
-1.9191161394119263,
0.24070023000240326,
-0.1439780443906784,
0.2956807315349579,
-0.1370922476053238,
1.0154966115951538,
0.20147651433944702,
-0.17036941647529602,
0.9394423961639404,
0.22702229022979736,
-0.7900873422622681,
-0.32632237672805786,
-0.27101901173591614,
0.22529971599578857,
-0.07467900216579437,
-0.7400248050689697,
-1.1534864902496338,
-1.022359848022461,
-0.29347848892211914,
-0.46550169587135315,
0.3461589813232422,
-0.6651021242141724,
0.4627234637737274,
0.49451944231987,
-0.08587668836116791,
-0.761777400970459,
0.21754002571105957,
-0.5863774418830872,
0.9092861413955688,
0.7068303227424622,
-0.7751837968826294,
0.23150630295276642,
0.032492075115442276,
-0.2025550752878189,
-0.3330978453159332,
-0.6536198854446411,
0.22641845047473907,
-0.7112603187561035,
-0.7079329490661621,
0.8813740015029907,
0.08763180673122406,
-0.8300464153289795,
-0.6620175838470459,
-0.06638496369123459,
0.30265775322914124,
1.7015599012374878,
0.18562684953212738,
-0.7203916311264038,
-0.1324201375246048,
0.22654880583286285,
-0.6076838374137878,
0.38743162155151367,
-1.3925392627716064,
-0.002972719259560108,
-0.3157385289669037,
0.48993027210235596,
-0.36200156807899475,
-0.473111093044281,
-0.09937680512666702,
0.6958755254745483,
0.16033609211444855,
0.19289778172969818,
0.32094836235046387,
-0.4170130789279938,
0.29079103469848633,
-0.005531078204512596,
0.03387872874736786,
-0.3138589560985565,
0.025125689804553986,
-0.4841061532497406,
0.5236978530883789,
-0.326660692691803,
0.4561116695404053,
0.022351205348968506,
-0.5798844695091248,
-0.8507111668586731,
0.3960419297218323,
-0.1206575259566307,
-1.0050750970840454,
0.33209148049354553,
0.36397239565849304,
0.7741858959197998,
-0.354316771030426,
-0.3430999517440796,
0.31501486897468567,
0.0949319526553154,
0.296761155128479,
0.22525450587272644,
-0.1475156992673874,
0.08566772937774658,
0.2785879373550415,
-1.03127920627594,
-0.13159574568271637,
-0.46958011388778687,
-0.1276039481163025,
0.19311374425888062,
-0.3243173658847809,
0.020184440538287163,
0.1142345741391182,
-0.06898782402276993,
-0.4238983392715454,
-0.02506321854889393,
0.28315767645835876,
-0.28090205788612366,
-0.027001535519957542,
-0.23483429849147797,
0.6989936828613281,
-0.18313318490982056,
0.15100805461406708,
0.21492987871170044,
-0.01704522781074047,
0.7977046370506287,
-0.05313865840435028,
-0.06366316229104996,
-0.3577263653278351,
0.3290162682533264,
-0.2218742072582245,
0.2848818600177765,
-0.08179108798503876,
-0.22424398362636566,
-0.12353699654340744,
0.237705260515213,
-0.3205187916755676,
-0.2653261721134186,
-0.08825743943452835,
0.2600163221359253,
-0.13413293659687042,
0.13496167957782745,
0.22097399830818176,
0.21265514194965363,
-0.4576769471168518,
-0.027513064444065094,
-0.09028401225805283,
-0.1932258903980255,
-0.3089972138404846,
-0.10163074731826782,
-0.06603403389453888,
-0.3648230731487274,
-0.6643429398536682,
0.2441951185464859,
-0.20909467339515686,
-0.18518561124801636,
0.4645257890224457,
-0.24320358037948608,
-0.0015717747155576944,
0.06762927025556564,
-0.3669130206108093,
-0.2870825231075287,
0.08645869046449661,
-0.5369255542755127,
-0.6658041477203369,
-0.22033582627773285,
0.3193697929382324,
0.06125325709581375,
-0.08193013817071915,
0.5502881407737732,
0.051622968167066574,
0.40099427103996277,
-0.4889378845691681,
-0.10918150842189789,
0.040329888463020325,
0.44281476736068726,
0.11817361414432526,
0.060464706271886826
] |
6,825,391 |
Aspirin kinetics and platelet aggregation in man.
|
Siebert D J DJ, Bochner F F, Imhoff D M DM, Watts S S, Lloyd J V JV, Field J J, Gabb B W BW
|
Clinical pharmacology and therapeutics . Vol. 33, No. 3, 1983 Mar
|
Our aims were (1) to determine the effect of six commercially available aspirin (ASA) preparations on in vitro platelet aggregation, and (2) to relate changes in platelet function to ASA kinetics. Each of six subjects took a single dose of one of the following preparations--600 mg Asproclear, 600 mg Bufferin, 600 mg Bi-prin, 600 mg compressed ASA, 650 mg Ecotrin, or 650 mg S.R.A.--in random order every 3 wk. Venous blood was drawn before and at 2, 4, 6, and 24 hr after ASA dosage to measure platelet aggregation in response to collagen and adenosine diphosphate and, at more frequent intervals, to characterize ASA kinetics. Asproclear, Bufferin, Bi-prin, and compressed ASA yielded peak plasma ASA levels of 28 to 56 mumol/l (5 to 10 mg/l) within 15 to 60 min and peak salicylic acid (SA) levels of 72 to 290 mumol/l (10 to 40 mg/l) within 2 hr. Ecotrin and S.R.A. yielded plasma SA levels of 14 to 87 mumol/l (2-12 mg/l) within 4 to 24 hr and no measurable ASA at any time after dosing. Platelet aggregation was inhibited to an equal extent by all preparations. The time course for this inhibition was the same for all preparations but Ecotrin (which led to a more delayed effect). There was significant recovery of collagen-induced platelet aggregation at 24 hr with all preparations but Ecotrin. With Ecotrin and S.R.A. there was inhibition of platelet aggregation in the absence of measurable circulating ASA. We postulate that this was due to acetylation of cyclooxygenase in the portal circulation and that inhibition of peripheral cyclooxygenase may be spared.
|
https://pubmed.ncbi.nlm.nih.gov/6825391/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial",
"Research Support, Non-U.S. Gov't"
] |
6825391
|
[
0.46923720836639404,
1.3065334558486938,
-1.4904168844223022,
-2.6915392875671387,
1.5089277029037476,
0.8928069472312927,
0.6566084027290344,
-0.5948081612586975,
-0.6775336861610413,
-0.7964933514595032,
-0.2641172409057617,
1.3024290800094604,
-0.38534507155418396,
-0.49338096380233765,
-0.10735853016376495,
-0.06323279440402985,
-1.0254935026168823,
0.140398770570755,
0.319394588470459,
-1.5340100526809692,
0.8700437545776367,
-1.5618128776550293,
-0.7310712337493896,
0.43756532669067383,
0.5908535718917847,
-0.5517696142196655,
0.6804162859916687,
1.0288114547729492,
0.45910561084747314,
1.606665015220642,
0.15288013219833374,
0.15916708111763,
1.0158454179763794,
0.04616895690560341,
-0.3284442126750946,
-0.7224555015563965,
0.8984524607658386,
0.057924091815948486,
-0.09866029024124146,
-0.1588858962059021,
0.391313374042511,
0.11771734803915024,
0.13560068607330322,
-0.2499726414680481,
1.672295331954956,
-0.15589532256126404,
0.04036878049373627,
-0.0638929009437561,
0.46165594458580017,
-0.706085205078125,
0.253260999917984,
-0.04116824269294739,
-1.1353315114974976,
-0.5634434819221497,
0.43039369583129883,
0.25032469630241394,
0.5542961359024048,
-0.30414843559265137,
0.9993470907211304,
0.38099050521850586,
0.12996114790439606,
0.05023042485117912,
0.20969811081886292,
-0.047181256115436554,
-0.25386843085289,
-0.3597196042537689,
0.8114362955093384,
0.5124124884605408,
-0.44184979796409607,
0.49879202246665955,
-0.799264669418335,
0.2263292372226715,
0.8677836656570435,
0.02276400662958622,
0.3523147404193878,
1.1862200498580933,
-0.11859425157308578,
0.40408796072006226,
0.25836181640625,
0.11607841402292252,
-0.7032217383384705,
0.816716194152832,
-0.364107221364975,
0.09576646983623505,
-0.2431202083826065,
1.3545738458633423,
-0.533991277217865,
-0.2483324557542801,
-0.1245451271533966,
-0.40065017342567444,
1.1902979612350464,
-0.4035987854003906,
-1.335444688796997,
-0.5209583640098572,
-0.32014408707618713,
0.6486004590988159,
-0.07723116129636765,
0.3450201451778412,
0.09510260820388794,
0.5277369022369385,
0.05288584530353546,
-0.07292233407497406,
0.26749107241630554,
0.5590698719024658,
-0.06473114341497421,
-0.13007736206054688,
0.17815165221691132,
0.08538275957107544,
-0.2918093204498291,
-0.4528675377368927,
-0.4836781322956085,
-0.30781230330467224,
-0.08066365867853165,
-0.4156481921672821,
0.37751224637031555,
0.3105342388153076,
-0.04158370569348335,
-0.31374919414520264,
-0.053469158709049225,
-0.3348504602909088,
0.10213559120893478,
0.3710569143295288,
-0.24675920605659485,
0.43634089827537537,
0.23078572750091553,
-0.5895326733589172,
0.3848569095134735,
-0.5755549669265747,
0.6232589483261108,
-0.24990558624267578,
-0.7731837630271912,
0.8019061088562012,
-0.4741286337375641,
-0.1570415496826172,
-0.45947444438934326,
-0.03140046074986458,
0.5397047996520996,
0.48615002632141113,
0.26917409896850586,
-0.3618377149105072,
-0.0838908776640892,
-0.40637364983558655,
-0.6491795182228088,
0.06349395960569382,
-0.9108951091766357,
-0.10230930149555206,
-0.5898866057395935,
0.4938611388206482,
-0.009653095155954361,
0.042541712522506714,
-0.3925345838069916,
-0.10571698844432831,
0.5127748847007751,
-0.13610884547233582,
-0.16212230920791626,
-0.20633888244628906,
0.2918471097946167,
0.37532365322113037,
0.24047014117240906,
-0.20989768207073212,
-0.29551559686660767,
-0.14699597656726837,
-0.16951319575309753,
-0.20996637642383575,
0.16327792406082153,
0.48030051589012146,
0.34289300441741943,
-0.030488600954413414,
-0.026167403906583786,
0.7005093097686768,
-0.6393631100654602,
-0.08650956302881241,
0.20313014090061188,
0.5282382369041443,
0.25455325841903687,
0.13776341080665588,
0.4732185900211334,
0.040065083652734756,
0.3383646309375763,
0.45593804121017456,
-0.34430748224258423,
0.15532639622688293,
-0.2801651954650879,
-0.2990786135196686,
0.043940264731645584,
-0.2049388438463211,
-0.07338539510965347,
-0.13563473522663116,
0.21779125928878784,
0.35549309849739075,
0.6754076480865479,
0.1255638301372528,
0.1846499741077423,
0.03497825190424919,
0.24175110459327698,
0.21106940507888794,
0.09848745167255402,
0.3406224250793457,
0.15878553688526154,
-0.1454126536846161,
-0.06267672777175903,
0.6694161891937256,
-0.05785591900348663,
0.44188427925109863,
0.34972408413887024,
0.1249295100569725,
-0.08529461175203323,
0.30196642875671387,
-0.1236330047249794,
0.0707436054944992,
0.355699360370636,
-0.09925907850265503,
0.1868678331375122,
0.31777605414390564,
-0.040430229157209396,
-0.18690486252307892,
-0.09572110325098038,
-0.058142345398664474,
-0.1877051740884781,
0.0630335807800293,
0.2574895918369293,
0.25607508420944214,
-0.1369772106409073,
-0.07873386144638062,
-0.19586774706840515,
-0.013140321709215641,
-0.15508587658405304,
-0.046753935515880585,
0.1108328253030777,
0.017618680372834206,
0.046435434371232986,
-0.02118854597210884,
-0.1812339872121811,
-0.1757153570652008,
-0.09084238111972809,
0.4845522344112396,
-0.052185866981744766,
0.26399973034858704,
0.2774658501148224,
0.016129568219184875,
-0.14169016480445862,
-0.461249440908432,
0.09717806428670883,
0.0594867505133152,
0.5986842513084412,
-0.3253105878829956,
-0.0872354507446289,
0.4534233808517456,
0.17274098098278046,
-0.0848972499370575,
0.23318520188331604,
-0.24642036855220795,
-0.18397410213947296,
0.08285346627235413,
0.18253928422927856,
-0.009023638442158699
] |
6,825,409 |
The influence of a high dietary intake of purine-rich animal protein on urinary urate excretion and supersaturation in renal stone disease.
|
Fellström B B, Danielson B G BG, Karlström B B, Lithell H H, Ljunghall S S, Vessby B B
|
Clinical science (London, England : 1979) . Vol. 64, No. 4, 1983 Apr
|
1. Eight recurrent renal stone-forming patients were housed in a metabolic ward and fed on a low (LPD) and a high (HPD) animal protein diet, which were isoenergetic. Metabolic studies were made after 2 weeks on each diet. 2. There was a 90% increase in urinary urate on HPD compared with LPD, whereas serum urate did not change consistently. 3. The urinary acid excretion increased by 200%, including a 100% increase in ammonium ion excretion. A fall in urine pH by 0.9 unit was also seen. 4. The calculated ion activities of the urines revealed a profound increase in the uric acid supersaturation, from undersaturation to supersaturation, and in some cases even surpassing the formation product ratio. The ammonium urate supersaturation also increased. The sodium urate supersaturation was unchanged, despite an induced natriuresis. 5. The risk of forming uric acid or ammonium urate crystals or stones in the urine was increased on a high protein diet, whereas the risk of forming sodium urate crystals was no greater than on a low protein diet. 6. As uric acid and ammonium urate crystals under certain conditions may adsorb a macromolecular fraction of the human urine, which inhibits calcium oxalate crystal growth, it is proposed that this mechanism, along with a decrease in urine pH, may also interfere with the inhibitory activity of calcium oxalate crystal growth and aggregation.
|
https://pubmed.ncbi.nlm.nih.gov/6825409/
|
[
"Clinical Trial",
"Controlled Clinical Trial",
"Journal Article",
"Research Support, Non-U.S. Gov't"
] |
6825409
|
[
-0.14333710074424744,
0.7201657891273499,
-2.4999568462371826,
-3.071014881134033,
1.3973430395126343,
1.2532074451446533,
0.3216410279273987,
-0.8705920577049255,
-2.188880681991577,
-1.2726631164550781,
0.36094456911087036,
1.5878223180770874,
-0.24494369328022003,
0.699522852897644,
0.18709294497966766,
-0.833064079284668,
-1.431868076324463,
0.051302842795848846,
0.28577810525894165,
-0.5770767331123352,
1.7179536819458008,
0.3811149597167969,
-1.4513968229293823,
0.6074276566505432,
0.6601893305778503,
-0.6118291020393372,
-0.3577989339828491,
0.9342969655990601,
1.4301172494888306,
0.3631325960159302,
-0.1723308563232422,
-0.06746553629636765,
-1.323188304901123,
-1.1608816385269165,
0.7051354050636292,
0.06733595579862595,
2.237562656402588,
-0.47995635867118835,
1.0541868209838867,
0.35206419229507446,
0.6151555776596069,
1.34684157371521,
-0.06440091878175735,
0.7332894802093506,
1.5997118949890137,
0.9576455950737,
0.6018259525299072,
-0.10851821303367615,
0.22748617827892303,
-0.18203748762607574,
-0.798051655292511,
0.6572018265724182,
-1.753519892692566,
-0.9537366628646851,
1.4798320531845093,
0.9330679774284363,
0.1473642736673355,
0.5986717939376831,
1.9054404497146606,
-0.05562671646475792,
0.6358234286308289,
1.0684213638305664,
-1.3577154874801636,
0.38792741298675537,
-1.2097259759902954,
-0.6265830397605896,
0.9286372065544128,
0.4139580726623535,
-0.48918625712394714,
1.056662678718567,
-0.4338657855987549,
0.2524227499961853,
0.3104028105735779,
0.21292929351329803,
0.8926087617874146,
1.00435209274292,
-0.6141707301139832,
-0.536999523639679,
-0.18175171315670013,
-0.16583988070487976,
-1.3124523162841797,
-0.37719568610191345,
-0.39517244696617126,
-0.3204555809497833,
0.08344579488039017,
1.4416683912277222,
-0.6720527410507202,
-2.330348253250122,
1.0863093137741089,
-0.5236856937408447,
0.3644367754459381,
-0.8313925862312317,
-1.3752821683883667,
0.5908688902854919,
0.3826938569545746,
0.04134245589375496,
0.15489891171455383,
-0.41977301239967346,
-0.4279613792896271,
-0.2317238450050354,
0.788952648639679,
-0.49652722477912903,
-0.0018711747834458947,
0.39268919825553894,
-0.22677288949489594,
-0.28759506344795227,
0.07594433426856995,
0.4225131869316101,
-0.04620957374572754,
-0.555931806564331,
-0.4372316598892212,
-1.1937854290008545,
-0.17311859130859375,
-0.167897030711174,
-0.04574879631400108,
0.23197661340236664,
-0.011585944332182407,
-0.19609636068344116,
-0.46308431029319763,
-0.7991001009941101,
0.24333515763282776,
0.12073947489261627,
-0.8868721723556519,
0.3479961156845093,
-0.39843153953552246,
-0.34247061610221863,
0.5855596661567688,
0.14637966454029083,
0.3596491813659668,
-0.7371938824653625,
0.4477689862251282,
0.2736145853996277,
0.1664668172597885,
-0.2459932118654251,
0.5829585194587708,
0.10735352337360382,
0.17187000811100006,
0.9677953720092773,
0.18187589943408966,
0.1592007428407669,
-0.2769060432910919,
-0.4212372303009033,
-0.4907057285308838,
0.3232376277446747,
-0.7367954850196838,
-0.49681738018989563,
-0.2237960249185562,
-0.4827785789966583,
-0.48801112174987793,
0.4808211326599121,
0.04995778948068619,
0.22295916080474854,
0.45302101969718933,
0.24903661012649536,
-0.44308462738990784,
0.0037715404760092497,
0.025967776775360107,
0.4862819314002991,
-0.053168885409832,
0.03147221729159355,
0.5812077522277832,
0.02893911302089691,
0.14662905037403107,
-0.04147721081972122,
0.136545792222023,
-0.20299339294433594,
0.04938437044620514,
0.07262738794088364,
-0.04581688344478607,
-0.6307789087295532,
-0.19111885130405426,
-0.5216543078422546,
-0.33848896622657776,
-0.17629435658454895,
0.048938751220703125,
-0.06803934276103973,
0.5935356616973877,
-0.0019382830942049623,
0.276980996131897,
0.06854915618896484,
-0.03039676696062088,
-0.1292659342288971,
-0.4808421730995178,
-0.2894749641418457,
-0.2536650002002716,
-0.7240714430809021,
-0.21988257765769958,
-0.926643967628479,
-0.14966163039207458,
0.17149464786052704,
0.39677196741104126,
0.33888474106788635,
-0.05911007523536682,
0.03542188182473183,
-0.14512330293655396,
0.8764829039573669,
0.18600690364837646,
-0.3200158476829529,
0.19406288862228394,
0.4204871654510498,
0.13256721198558807,
0.2907108664512634,
-0.04685233160853386,
0.2736932039260864,
0.052303411066532135,
-0.05468481406569481,
-0.12987211346626282,
0.0881849154829979,
-0.16942986845970154,
0.2717074751853943,
0.344974160194397,
0.20507416129112244,
0.5297031998634338,
-0.07245873659849167,
0.3554459512233734,
0.34853044152259827,
-0.27978307008743286,
0.5218630433082581,
-0.008863397873938084,
-0.33809930086135864,
0.3018231689929962,
0.09026652574539185,
-0.4519028067588806,
-0.5221459865570068,
0.0953894779086113,
0.14101843535900116,
-0.47005441784858704,
-0.08084818720817566,
-0.2799057066440582,
0.09310060739517212,
-0.23173752427101135,
-0.4038294851779938,
-0.19612520933151245,
-0.04913435876369476,
0.08448253571987152,
-0.12694638967514038,
-0.13868923485279083,
0.2556557357311249,
0.2616318464279175,
0.02690640278160572,
-0.05036672577261925,
-0.2965235114097595,
-0.28186753392219543,
-0.015304668806493282,
0.09535995870828629,
-0.1510966420173645,
-0.38057559728622437,
0.01436211820691824,
0.273842453956604,
-0.3196353018283844,
0.05985305458307266,
0.047587573528289795,
0.06604992598295212,
-0.17328689992427826,
0.09631364047527313,
0.04043348506093025
] |
6,825,410 |
A Signal Detection Theory analysis of the effect of chest cage restriction upon the detection of inspiratory resistive loads.
|
Narbed P G PG, Marcer D D, Howell J B JB, Spencer E E
|
Clinical science (London, England : 1979) . Vol. 64, No. 4, 1983 Apr
|
1. By the use of Signal Detection Theory techniques, resistive load detection sensitivity was estimated in six normal subjects, and compared with detection when the chest cage was strapped in the position of full expiration. 2. With chest cage restriction there was both a decrease in detection sensitivity and an increase in the willingness to report the presence of an added load to breathing. 3. This suggests that the similarity of detection in chest clamping and control previously reported was due partly to increased detection bias with chest clamping. 4. These results have implications concerning the dependence of detection on afferent information from the chest wall.
|
https://pubmed.ncbi.nlm.nih.gov/6825410/
|
[
"Clinical Trial",
"Journal Article",
"Randomized Controlled Trial"
] |
6825410
|
[
-2.6755924224853516,
3.121535301208496,
-0.5813280344009399,
-3.3760156631469727,
0.8624722361564636,
-0.7895155549049377,
-0.4632026255130768,
0.028898250311613083,
-1.5281741619110107,
-0.5173304677009583,
1.3621622323989868,
1.4514646530151367,
-0.3261585533618927,
0.793197512626648,
0.19755646586418152,
1.2466264963150024,
-1.7466927766799927,
-0.36584722995758057,
0.8537420630455017,
-1.1301908493041992,
-0.3516785204410553,
0.27288195490837097,
-0.7147331833839417,
-0.24633236229419708,
0.34436851739883423,
0.7079943418502808,
0.3779653310775757,
1.7266196012496948,
-1.1897889375686646,
-0.441552072763443,
0.5674802660942078,
0.05323977395892143,
-0.310322105884552,
-0.25522223114967346,
-0.12656201422214508,
-0.897598922252655,
1.1350480318069458,
-1.5664877891540527,
-0.15403436124324799,
-0.9344101548194885,
0.7589319348335266,
1.309525728225708,
0.6284553408622742,
-0.7923753261566162,
1.2866439819335938,
-1.4825122356414795,
-0.7691131830215454,
-0.13423852622509003,
-0.777762770652771,
-0.5906885266304016,
-1.0167386531829834,
-0.04774268716573715,
0.08333931118249893,
0.020597968250513077,
1.4535908699035645,
-0.6717352867126465,
0.13028444349765778,
-0.18954434990882874,
0.9227946996688843,
-0.3633950352668762,
0.6648505330085754,
0.025716131553053856,
0.5956332087516785,
1.1148475408554077,
-0.4864940047264099,
0.12043382227420807,
-0.540632963180542,
-0.2894807755947113,
0.003760873107239604,
-0.47618648409843445,
0.16941195726394653,
-0.2391577661037445,
0.6554128527641296,
0.38446447253227234,
0.5374308824539185,
-0.7616381645202637,
-0.5474972128868103,
0.3676478862762451,
0.9959493279457092,
1.8385363817214966,
-1.616692304611206,
-0.4796917140483856,
-0.570631206035614,
0.09959657490253448,
0.24810592830181122,
-0.5885933637619019,
0.4898519515991211,
-0.33464011549949646,
0.6499620676040649,
0.29051628708839417,
-0.48406463861465454,
0.18185512721538544,
-0.12489662319421768,
-0.6216606497764587,
0.33668726682662964,
0.5546367168426514,
0.04741515591740608,
-0.3460007905960083,
-0.0860382467508316,
-0.1497771441936493,
-0.16285604238510132,
-0.1901639699935913,
-0.22864745557308197,
-0.5134762525558472,
0.13831034302711487,
-1.0079964399337769,
0.025651706382632256,
-0.68973308801651,
0.4095262289047241,
-0.38235360383987427,
-0.4084765613079071,
-0.14766712486743927,
-0.5378490686416626,
-0.5361895561218262,
0.15629889070987701,
-0.38509345054626465,
1.4247512817382812,
0.7362750768661499,
0.46097487211227417,
-1.6120065450668335,
0.17459367215633392,
0.7066709995269775,
0.45622265338897705,
0.7707282304763794,
0.43868669867515564,
-0.1532682180404663,
0.13502949476242065,
-0.08435532450675964,
-1.0547021627426147,
-0.43738827109336853,
-0.2828644812107086,
-0.011052336543798447,
0.21316547691822052,
-0.663195788860321,
-0.6155572533607483,
-0.12833456695079803,
0.11457894742488861,
1.1542143821716309,
0.11554054915904999,
0.2870992124080658,
-0.07330583035945892,
0.46864956617355347,
0.8329097032546997,
0.6943593621253967,
-0.8003496527671814,
-0.7268954515457153,
-0.10358686745166779,
0.30342596769332886,
-0.37458688020706177,
-0.2438913732767105,
0.33839526772499084,
1.0485738515853882,
1.0492173433303833,
-0.5150855183601379,
0.49340054392814636,
-0.7029693722724915,
-0.8241410851478577,
0.3409557640552521,
-0.25768598914146423,
0.12740366160869598,
1.0426040887832642,
-0.14021115005016327,
-0.7582410573959351,
0.42157432436943054,
0.5554964542388916,
-0.2279299795627594,
0.3840305209159851,
-0.8891134858131409,
-0.22376829385757446,
-0.33636894822120667,
0.12673546373844147,
-0.47095054388046265,
0.40906211733818054,
0.18737702071666718,
-0.5189301371574402,
-0.37632042169570923,
-0.9596097469329834,
0.9091752171516418,
0.16343465447425842,
-0.38154155015945435,
0.35477471351623535,
0.008151376619935036,
-0.5081110596656799,
0.1377842277288437,
0.20453982055187225,
-0.3006576895713806,
-0.36470451951026917,
-0.6144697666168213,
0.09666303545236588,
-0.39165303111076355,
0.21688959002494812,
0.2922042906284332,
-0.32285958528518677,
-0.7312145829200745,
-0.0608854703605175,
1.0083149671554565,
-0.2825903296470642,
-0.6315931677818298,
0.4101712703704834,
0.30641159415245056,
0.4011465013027191,
0.15616339445114136,
-0.24736617505550385,
-0.28256314992904663,
0.2310800403356552,
0.1976862996816635,
-0.4682697057723999,
0.30896440148353577,
0.06397013366222382,
0.38464412093162537,
-0.09753573685884476,
0.28461721539497375,
-0.3194761276245117,
0.351600706577301,
-0.0010914667509496212,
0.427013099193573,
0.10683365911245346,
-0.1541067212820053,
-0.39521652460098267,
0.13604362308979034,
-0.17800995707511902,
0.5908918976783752,
0.22279076278209686,
0.5792534351348877,
-0.06097564473748207,
0.33564460277557373,
-0.06756872683763504,
0.10207085311412811,
0.7204704284667969,
-0.24755363166332245,
-0.2857462465763092,
-0.6538567543029785,
-0.1760377138853073,
-0.511569619178772,
0.09396917372941971,
-0.09989248216152191,
0.08555887639522552,
-0.3344799280166626,
0.10973092168569565,
-0.1329318732023239,
0.393104612827301,
-0.3052403926849365,
-0.04815145954489708,
-0.18893775343894958,
0.5261344909667969,
-0.04491138458251953,
-0.22031736373901367,
-0.43420714139938354,
-0.20735551416873932,
-0.26556670665740967,
0.37793391942977905,
0.2890597879886627,
0.5935676693916321,
0.42338424921035767,
0.44985756278038025,
0.08175864070653915
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.