PMC_ID
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PMC11274378
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Figure_2
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oa_package/f5/26/PMC11274378.tar.gz
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['Schematic depiction of the distribution of mechanosensitive Piezo1 and Piezo2 in the gastrointestinal tract.']
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Figure 2 Schematic depiction of the distribution of mechanosensitive Piezo1 and Piezo2 in the gastrointestinal tract.
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yes
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PMC8543996
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Figure_2
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oa_package/c9/d4/PMC8543996.tar.gz
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['Areas of small sequestrum and osteolytic radiolucencies were seen within the newly formed bone (C), which were alternating with each other.']
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Figs 2A to C (A and B) Axial and sagittal views show bony lamellae both buccally and lingually; (C) Areas of small sequestra and osteolytic radiolucencies seen within the new bone
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yes
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PMC10590452
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Figure_5
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oa_package/70/4f/PMC10590452.tar.gz
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[' 5a c).', ' 5d).', ' 5e).', 'sTREM2 attenuates tau pathology and memory loss in tau P301S mice.', 'We further performed behavioral tests to investigate the effect of sTREM2 on cognitive function.', ' 5f, g) and longer time in the target quadrant during the probe test (', ' 5h) than tau P301S mice injected with AAV-vector.', ' 5i).', ' 5j, k).']
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Fig. 5 sTREM2 attenuates tau pathology and memory loss in tau P301S mice. p-Tau S202/T205 immunostaining ( ) and quantification ( ) of 7-month-old wild-type mice and tau P301S mice overexpressing AAV-vector or AAV-sTREM2. Scale bar, 250 m. (mean s.e.m.; one-way ANOVA, =6 mice per group). Western blots showing the phosphorylation of tau and GSK3 (mean s.e.m.; one-way ANOVA, =8 mice per group). Electron microscopy of synapses in the hippocampus (left). Stars indicate synapses. Scale bar, 1 m (mean s.e.m.; one-way ANOVA, =6 mice per group). Golgi staining revealed the dendritic spines from the apical dendritic layer of the CA1 region (left). Scale bar, 15 m. Quantification of spine density (right) (mean s.e.m.; one-way ANOVA, =6 mice per group). Morris water maze analysis of the escape latency ( ) and escape latency on day 4 ( ) (mean s.e.m.; =9 mice in WT, P301S-sTREM2 groups, =8 mice in P301S-Vector group; one-way ANOVA). Probe trial of the Morris water maze test (mean s.e.m.; =89 mice per group; * <0.05, one-way ANOVA). Y-maze analysis as time spent in new arms (mean s.e.m.; =9 mice in WT, P301S-sTREM2 groups, =8 mice in P301S-Vector group; one-way ANOVA). The slope of fEPSPs after HFS recorded in hippocampal slices. The arrow indicates the onset of HFS. Quantitative analyses of normalized fEPSPs at 6080min. Boxwhisker plot (displaying the Max/Min at the whiskers, the 75/25 percentiles at the boxes, and the median in the center line). (mean s.e.m.; =4 mice per group; two-way ANOVA). * <0.05, ** <0.01, *** <0.001. AAVs adeno-associated virus, HFS high-frequency stimulation, LTP long-term potentiation.
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yes
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PMC9407377
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Figure_17
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oa_package/af/a2/PMC9407377.tar.gz
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[]
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Figure 17 A 30-year-old male with Maffucci syndrome: AP radiograph of the hand demonstrates multiple enchondromas.
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yes
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PMC5693919
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Figure_6
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oa_package/06/88/PMC5693919.tar.gz
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[' 6), the increases in the serum levels of the enzymes ALT and AST released by injured hepatocytes in rats with cirrhosis (both P values 0.', 'HGF overexpression in grafted DPSCs enhances the hepatic functional recovery of rats with cirrhosis.', '\nDiscussionIn this study, we investigated the impacts of hHGF overexpression on the in vivo biological behaviors and the therapeutic efficacy of DPSCs for the treatment of liver cirrhosis.']
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Figure 6 HGF overexpression in grafted DPSCs enhances the hepatic functional recovery of rats with cirrhosis. ( ) ELISAs of the serum ALT ( ), AST ( ) and albumin ( ) levels of the rats in each group. ns, nonsignificant; ** <0.05; ** <0.01; *** <0.001.
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yes
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PMC10366931
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Figure_1
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oa_package/b1/b3/PMC10366931.tar.gz
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['The narrowing of encased arteries is typically seen in meningiomas and may be a useful sign to distinguish them from pituitary adenomas, which do not result in arterial narrowing () [6].', 'However, large and calcified masses may demonstrate an overall low signal on T2WI, which may be misdiagnosed as lymphoma or melanoma (1) [51].', 'In contrast, cancellous osteomas show central bone marrow signal intensity on MRI and low signal in the periphery due to compact bone (2).', 'Peritumoral cysts at the tumor brain interface may be present when the tumor extends intracranially, which is highly suggestive of olfactory neuroblastoma (3) [2,59,60].', 'Ectopic pituitary adenomas may occur within the sphenoid sinus, clivus, and nasopharynx along the expected course of the craniopharyngeal canal (4).', 'Although the majority of pituitary adenomas have a benign histology, they can be biologically aggressive and infiltrate the skull base, clivus, and sphenoid sinus (5).', 'The solid portions show contrast enhancement, and on MRI, the cystic components may present with variable signal intensities depending on their contents of protein, cholesterol, or hemorrhage (6) [63].', 'Following contrast administration, CT and MRI both show a homogeneous enhancement of the LCH lesion and associated soft tissue components (7) [68,69].', 'The lesion does not enhance centrally, but reactive peripheral enhancement can be present, although difficult to depict due to the intrinsic high T1 signal of lesion (8) [2,70].', 'Enhancement is variable and often appears inhomogeneous with a honeycomb pattern, which is caused by epithelioid cells surrounding lakes of mucinous material or necrosis (9) [74,75].', '00119733317Meningiomas in three different patients.', '1Ossifying fibroma.', '2Osteomas in two different patients.', '3Olfactory neuroblastoma.', '4Exophytic/ectopic-intrasphenoidal pituitary adenoma.', '5Giant invasive macroadenoma.', '6Adamantinomatous craniopharyngioma in a child.', '7Langerhans cell histiocytosis in a 9-month-old boy.', '8Cholesterol granuloma.', '9Chordoma.']
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Figure 1 Meningiomas in three different patients. ( ) Sagittal CT and ( ) sagittal postcontrast T1W MR images demonstrate a homogenously enhancing extra-axial mass lesion (red arrow) at the anterior cranial fossa/planum sphenoidale with small dural tails (blue arrows) and hyperostosis (white arrow). ( ) Coronal CT and ( ) coronal postcontrast fat-saturated T1W images show an anterior clinoid process meningioma (red arrow) with dural tails (blue arrows), hyperostosis (white arrow), and tumoral calcification. ( ) Axial T2W and ( ) axial postcontrast T1W images reveal a right cavernous sinus meningioma extending through the petroclival dura, tentorium, and paraclinoid dura. The mass completely encases the right ICA with significant narrowing (black arrows).
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yes
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PMC10453870
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Figure_4
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oa_package/88/e0/PMC10453870.tar.gz
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['Additionally, morphologically changed neurons (arrows) were shrunk, and tightly packed with pyknotic nuclei in the granular layer, likely due to neuronal tissue remodelling that can be identified in mild hHcy conditions ().', 'Illustrative micrographs of CV-stained brain sections were used for statistical analysis to evaluate changes in the number of disintegrated neurons in the DG area of the rat hippocampus.']
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Figure 4 Illustrative micrographs of CV-stained brain sections were used for statistical analysis to evaluate changes in the number of disintegrated neurons in the DG area of the rat hippocampus. ( ) DG region of the hippocampus displays the C and MDG groups at 10 magnification in the left row, with the corresponding groups at high (400) magnification (rectangle) in the right row. Morphologically altered neurons with pyknotic nuclei are indicated by an arrow ( = 8 per group). The coronal rat brain section depicted in ( ) has been redrawn from Paxinos and Watson [ ], illustrating the DG photographed area (red rectangle). ( ) The number of neurons displaying degeneration marks in the hippocampuss DG region for the control and MDG groups. The significance of differences in the group means was assessed using an unpaired -test. The results are expressed as the mean SD for each group, with a sample size of = 8, *** < 0.001 compared to the control group.
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yes
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PMC8680235
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Figure_3
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oa_package/69/09/PMC8680235.tar.gz
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['We planned a show-and-tell session to showcase some of the most frequently used transcatheter devices ().', 'Hands-on skills session.']
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Figure 3 Hands-on skills session. Transducer handling and optimal views were demonstrated simultaneously to teach how to obtain optimal transthoracic echocardiography images. Transesophageal echocardiography was taught on a simulator model, starting with intubation technique to acquiring optimal views. The cardiac catheterization skills demonstration included best practices to obtain vascular access and basics of performing right heart catheterization and coronary angiography. A show-and-tell session demonstrated commonly used transcatheter devices to treat structural heart disease. Porcine heart dissection was demonstrated on screen to explain cardiac anatomy. Pacemaker and defibrillator basics and interrogation were demonstrated live from our studio. A prerecorded video was used to explain the basics of mechanical circulatory support devices.
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yes
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PMC3868614
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Figure_6
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oa_package/a6/3f/PMC3868614.tar.gz
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['Therefore, we evaluated the effect of 14-3-3 overexpression on synapses by measuring synaptophysin protein level ().', 'Ln-vector infected neurons displayed numerous synaptophysin clusters in the cell soma and neurites, as expected (A).', 'g006Overexpression of 14-3-3 downregulates synaptophysin protein level in rat hippocampal primary neurons in culture Neurons infected with Ln-14-3-3 or Ln-vector were analyzed for synaptophysin protein levels by immunocytochemistry or Western blotting.', 'g006"/>Western blot analysis determined that, compared to Ln-vector infected neurons, the intensity of the synaptophysin protein band was significantly less in Ln-14-3-3 -infected neurons (compare lane 2 with lanes 3 and 4 in B).', 'Similar observations were made when another anti-synaptophysin antibody was used (B, upper panel).', '14-3-3 overexpression did not, however, affect the levels of post-synaptic marker protein, PSD-95, or the synaptic adhesion protein N-cadherin, in neurons (B).', 'Treated neurons were analyzed by Western blotting and the relative amounts were determined as per .', 'However, 14-3-3 overexpression significantly downregulates synaptophysin protein levels (), suggesting its involvement in synapse elimination.']
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10.1371/journal.pone.0084615.g006
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yes
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PMC8079330
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Figure_1
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oa_package/60/3c/PMC8079330.tar.gz
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['The precise angles at which these views are obtained will vary slightly from patient to patient ( 1).', ' 1Example of the triple shot series of a screw placed in the anterior-superior quadrant with 10 mm of screw penetration.', 'This series consisted of the obturator outlet, iliac oblique, and quad views ( 1).']
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Figure1 Example of the triple shot series of a screw placed in the anterior-superior quadrant with 10 mm of screw penetration. (a) Iliac oblique, (b) quad view, and (c) obturator outlet. The photos of the model pelvis taken at the trajectory of the fluoroscopy tube to obtain (d) iliac oblique, (e) quad view, and (f) obturator outlet.
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yes
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PMC1994044
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Figure_1
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oa_package/c6/32/PMC1994044.tar.gz
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['As the activated vessel wall contains multiple growth factors and vasoactive substances, we recently considered if the interaction of these agents might have an additive effect on GAG elon-gation both PDGF and TGF (at maximally effective doses) increase GAG length and these effects are clearly additive ().', 'Stimulation of vascular smooth muscle cells with both TGF- 1 and PDGF has an additive effect to increase [35S]-sulfate incorporation into proteoglycans.']
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Figure 1 Stimulation of vascular smooth muscle cells with both TGF-1 and PDGF has an additive effect to increase [ S]-sulfate incorporation into proteoglycans. Human VSMC treated with DMEM (), PDGF (P, 50 ng/ml), TGF-1 (T; 1 ng/mL) or PDGF plus TGF-1 (P + T; 50 ng/mL and 1 ng/mL respectively) for 24 h were metabolically labelled with S-SO ( ) SO -labeled proteoglycans secreted into the medium were analyzed by CPC precipitation. ( ) SDS-PAGE analysis of secreted PGs 20 000 cpm were loaded per lane. Gels were visualized by phospho-imaging. : PDGF: platelet-derived growth factor;TGF: transforming growth factor; VSMC: vascular smooth muscle cell.
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yes
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PMC3078329
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Figure_4
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oa_package/8e/cb/PMC3078329.tar.gz
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['2+ T cell populations revealed that IL-23R-deficient CD4+ T cells were indistinguishable from WT CD4+ T cells in their ability to accumulate in the MLN and inflamed colon of colitic mice ( S4 and 4A).', 'As shown ( 4B), even under homeostatic conditions, in the presence of WT T cells, Il23r / T cells showed no deficiency in their capacity to accumulate in the colon and to compete with WT T cells for this niche.', 'In these mixed chimeras, under inflammatory conditions, we found a similar contribution to the CD4+ T cell pool in the colon from WT and Il23r / T cells ( 4C).', ' 4IL-23 Controls T cell Accumulation in the Intestine via a Cell-Extrinsic MechanismC57BL.']
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Figure3 IL-23 Directly Promotes Intestinal Tcell Proliferation (A and B) C57BL.6. mice were transferred with 4 10 CFSE-labeled CD4 CD45RB Tcells from WT or donors and sacrificed 12 days after transfer. (A) Total CD4 Tcell numbers and (B) representative flow cytometry plots showing CFSE dilution profiles of Tcells from the spleen and colon are presented. (CE) C57BL.6. mice were transferred with 4 10 CD4 CD45RB Tcells from WT or donors and sacrificed when recipients of WT Tcells developed clinical signs of disease (6 weeks after transfer). IL-17A, IFN-, and Ki67 expression in CD4 Tcells from the colon were assessed by intracellular flow cytometry after invitro restimulation with PMA and ionomycin. (C) Frequencies, (D) representative flow cytometric plots (numbers in gate represent frequencies), and (E) total numbers of IL-17A IFN- Ki-67 , IL-17A IFN- Ki-67 , and IL-17A IFN- Ki-67 CD4 Tcells in the colon. Data represent pooled results from two independent experiments (A and B) or of a single experiment (CE), bars represent the mean, error bars represent the SEM, and each symbol represents an individual mouse. Statistical significance was determined with the Mann-Whitney test, n = 4-11 (WT), n = 5-11 ( ).
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yes
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PMC5352325
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Figure_2
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oa_package/74/87/PMC5352325.tar.gz
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['Microscopic lesions in kidney infected with the DHAV-1 H strain and CH60 strainRepresentative histopathological changes were detected by standard HE Staining (n = 5).']
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Figure 2 Microscopic lesions in kidney infected with the DHAV-1 H strain and CH60 strain Representative histopathological changes were detected by standard HE Staining ( = 5). Representative instances of cellular apoptosis and necrosis are indicated as red arrows and green arrows, respectively. Glomerulonephritis were also identified, especially in the later stage of infection. The brightness and contrast are slightly modified to create a uniform background.
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yes
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PMC10493862
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Figure_6
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oa_package/10/58/PMC10493862.tar.gz
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['T1-isointense, T2-hyperintense signal, T1-post-contrast enhancementMagnetic resonance and computed tomography (CT) examinations of spine.']
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Figure 6 Magnetic resonance and computed tomography (CT) examinations of spine. PT 36 7-year-old boy with Iintervertebral disc calcification arrow. A) T1-weighted sag, B) T2-weighted sag, C) T2-weighted short time inversion recovery TIRM sag, D) CT MPR sag bone window. CT of the spine confirmed the presence of calcification. MRI of the cervical spine showed an altered signal intensity involving the intervertebral disc at C3-4 with areas of T1 and T2 hypointensity consistent with calcification
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yes
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PMC11474045
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Figure_3
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oa_package/b4/54/PMC11474045.tar.gz
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[]
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Fig. 3. PTX3 induces activation of retinal macroglia. ( ) Mouse retinal explants from WT or PTX3 mice were treated ex vivo with 5 ng/ml TNF- for four hours and then stained for GFAP (red). (Scale bar, 50 m.) ( ) Quantification of GFAP signal in retinal explants using the raw integrated density per m of retinal tissue. ** < 0.01; ns: nonsignificant, n 5. ( ) Human retinal astrocytes were treated with vehicle, 5 ng/ml PTX3, or 5 ng/ml TNF-, and the release of proteins PAI-1, IL6, and IL8 was quantified by ELISAs in culture supernatants collected after 72 h. * < 0.05; ** < 0.01; ns: nonsignificant, n = 5. ( ) Staining of retinal astrocyte cultures after treatments for GFAP (red). Quantification of GFAP staining was performed using the raw integrated density. * < 0.05; *** < 0.001; ns: nonsignificant, n 6. (Scale bar, 50 m.) ( ) Protein lysates from astrocyte cultures were assessed by western blotting, and ODs were used for relative quantification in relation to -actin. * < 0.05, n = 3.
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yes
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PMC10220457
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Figure_1
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oa_package/d6/54/PMC10220457.tar.gz
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['The physical examination showed a similar diffuse poikilodermatous pattern and scattered adherent scale with an erythematous base, which was more prominent on the sun-exposed areas of the trunk and portions of the extremities, with or without underlying sclerosis ().', 'Clinical presentation demonstrating photodistributed poikilodermatous chronic graft-versus-host disease.']
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Fig 1 Clinical presentation demonstrating photodistributed poikilodermatous chronic graft-versus-host disease. ( ) Diffuse scaling, hyperpigmentation, and thickening of skin with mottling appearance, interestingly only in sun-exposed surfaces of the skin as shown on right side of the upper portion of the back. ( ) Red, crusty patches with slight thickening on left side of the chest with diffuse actinic keratoses. ( ) Scattered pink papules with slight scale and superficial excoriation overlying a well-circumscribed annular plaque on the right side of the leg. ( ) Diffuse scaling, hyperpigmentation, and thickening in mottled skin on scalp.
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yes
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PMC10586845
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Figure_4
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oa_package/1d/f5/PMC10586845.tar.gz
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['.']
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Figure 4. Small bowel biopsy (magnification: 400). Hematoxylin-eosin staining of the small bowel biopsy demonstrates malignant epithelial nests and glands involving the serosal surface and bowel muscle. The neoplastic cells have enlarged hyperchromatic and pleomorphic nuclei with variable nucleoli, visible mitoses, and apoptotic debris.
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yes
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PMC5529975
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Figure_5
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oa_package/97/cc/PMC5529975.tar.gz
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['PathophysiologyPathogenic mechanisms of axonal degeneration and cell death in the genetic LMN syndromes are a complex interaction of multiple factors (figure 5).']
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Figure5 Proposed pathogenic mechanisms for LMN syndromes. LMN syndromes may arise from disease processes affecting the anterior horn cell or the motor axon and/or its surrounding myelin. (A) A variety of mechanisms have been implicated in the degenerative and hereditary syndromes including mitochondrial dysfunction, altered RNA processing and impaired axonal transport (see text for further details). (B) Anti-GM1 antibodies may bind to GM1 in the paranodal region leading to disruption of ion channel clusters and paranodal anatomy. Although not a purely LMN syndrome, IgG4 antibodies against NF155 and CNTN1 have recently been described and may similarly disrupt paranodal anatomy resulting in a sensorimotor neuropathy. CNTN1, contactin-1; LMN, lower motor neuron; NF155, neurofascin-155.
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yes
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PMC5491558
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Figure_4
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oa_package/45/35/PMC5491558.tar.gz
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['Schematic representation of the involvement of MMPs and effects of A 1 40 and A 1 42 in the blood-brain barrier (BBB) and BCSFB in Alzheimer s disease (AD) pathology.']
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Figure 4 Schematic representation of the involvement of MMPs and effects of A140 and A142 in the blood-brain barrier (BBB) and BCSFB in Alzheimers disease (AD) pathology. Choroid plexus epithelial (CPE) cells and brain endothelial cells (BECs) are tightly connected by tight junctions (TJs) and form BCSFB and BBB monolayers, respectively. (1) An intracerebroventricular injection of A142 results in MMP, cytokine and chemokine secretion from CPE cells into CSF. The secreted MMPs further damage TJs at the BCSFB and increase permeability (orange; Brkic et al., ). (2) A142 interacts with receptor for advanced glycation end products (RAGE) in the BBB, resulting in the expression of MMPs, dysregulation of TJs and breakdown of the BBB (red; Kook et al., ). (3) Keaney et al. ( ) showed that A140 peptide leads to lower expression of TJ proteins and allows A40 monomers to diffuse from brain to blood (green). The frame describes changes in CPE cell function that are associated with AD, including the lower production of CSF, lower expression of AQP-1 in CPE cells and lower concentrations of transthretin (TTR) in CSF in the 3xTg-AD mouse model (Gonzlez-Marrero et al., ).
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yes
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PMC4813706
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Figure_2
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oa_package/a7/9d/PMC4813706.tar.gz
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['Accordingly, the comparison between FFPE and frozen tissues showed almost identical relative abundances for the most common and functionally relevant histone modifications found in four peptides from histone H3 (3 8, 9 17, 18 26 and 27 49, A).', '0001, B) was comparable to the correlation between histone preparations obtained from adjacent FFPE sections from the same mouse spleen (r = 0.', '054510/DC1">supplemental Table S2 and bottom panel).', '.']
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Fig. 2. , Percent relative abundances (%RA) profiles for H3 and H4 peptides from frozen or FFPE samples for mouse spleen (top panel) or liver (middle panel) stored for few weeks or mouse spleen stored for 6 years (bottom panel). Error bars represent the standard error from two independent experiments (top panel) or duplicate measurements (middle and bottom panels). , hPTM %RA correlation between frozen cells and FFPE samples obtained from the mouse and liver spleen samples shown in panel . Pearson correlation coefficients (r) and values are shown. The spleen tissues stored for few weeks or 6 years derive from different mice.
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yes
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PMC9445312
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Figure_1
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oa_package/d2/4b/PMC9445312.tar.gz
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['Ultrasonographic images of the thyroid and lateral lymph nodes.']
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Figure 1 Ultrasonographic images of the thyroid and lateral lymph nodes. ( ) The thyroid tissue displayed a heterogeneous echoic appearance on gray-scale sonography. ( ) Cervical lymph nodes showed round shape and absence of hilum on gray-scale sonography. ( ) CDFI showed different vascular distribution of cervical lymph nodes. ( ) A mixed-echoic cervical lymph node with more than 90% of cystic change revealed no blood flow signal inside this lymph node. ( ) A heterogeneous echoic cervical lymph node showed rich blood flow signal inside and around this lymph node. ( ) A heterogeneous echoic cervical lymph node showed rich blood flow signal around this lymph node.
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yes
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PMC11118324
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Figure_4
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oa_package/d3/57/PMC11118324.tar.gz
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[', 2008) These ground-truth measures were estimated from Weber and colleagues .', ').', 'The estimated area boundary locations were supported by comparison of cortical area boundaries as defined in the M132 atlas (A,B) (N.', ', 2014), we also examined the association between R2* and T1w/T2w-FLAIR, an indirect proxy measure of cortical myelin density (A, C) (Glasser and Van Essen 2011, Autio et al.', '10) (D).', 'Dense vascularity in these areas, the sharp gradient-ridges observed between surrounding areas and co-alignment with existing areal atlases further support this hypothesis (A, B).', 'Analogous to cortical circuitry, our study reveals the large-scale replication of translaminar vascular network motifs in primates (B, C, D).', 'Cytochrome-c oxidase (CO) activity, capillary and large vessel volume fractions were estimated from their .', '594068v3-f0003" position="float"/>.']
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Figure 4. Variations in vascular network architecture reveal cortical area boundaries. Ferumoxytol induced change in transverse relaxation rate (R *) displayed at a representative equivolumetric layer 4b (EL4b) (N=4). Overlaid black lines show exemplary M132 atlas area boundaries. R * gradients co-align with exemplary areal boundaries. Red arrow indicates an artifact from inferior sagittal sinus. Average mid-thickness weighted T1w/T2w-FLAIR myelin and cortical thickness maps.
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yes
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PMC10679581
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Figure_4
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oa_package/1c/59/PMC10679581.tar.gz
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['Pseudoaneurysm.']
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Figure 4 Pseudoaneurysm. A 64-year-old patient who sustained a fracture of the clavicle after trauma to the left shoulder due to a car accident. (a) Computed tomography (CT) angiography revealed a large pseudoaneurysm of the subclavian artery. The patent lumen (red arrow) and the wall (yellow arrow) are visible on the axial plane. (b) CT angiography reformatted on the sagittal plane demonstrated the lumen of the subclavian artery (red dashed circle), the wall of the pseudoaneurysm (yellow arrow) with parietal thrombus, and a fracture of the clavicle (white arrow). This image offers a good clue about the mechanism of injury that created the pseudoaneurysm: the distal stump of the fractured clavicle probably pierced the subclavian artery against the first rib, damaging the arterial wall. (c) Three-dimensional volume rendering offers an optimal depiction of the relationship of the pseudoaneurysm with bony structures.
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yes
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PMC6839469
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Figure_3
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oa_package/50/eb/PMC6839469.tar.gz
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['Elevated GFAP expression and A deposition at 24 weeks following CCI or mFPI.']
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Fig. 3 Elevated GFAP expression and A deposition at 24 weeks following CCI or mFPI. Immunostainings, revealed that there was no significant increase in reactive astrocytes, GFAP (green) and A deposits (6E10, red) in tg-ArcSwe mice at 12 weeks after CCI or mFPI. At24 weeks, there was a clear increase in both GFAP-expression and A deposition in both injury groups at, compared to uninjured controls (A). Analysis of the fluorescence signal confirmed that there was a significant increase in GFAP-expression and A deposition 24 weeks after CCI or mFPI (B-C). The data was analyzed by nonparametric Mann Whitney test and the graphs display meanSEM. Scale bars: Low magnification=20 m, high magnification=50 m. ** <0.01, *** <0.001.
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yes
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PMC2292681
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Figure_1
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oa_package/d7/74/PMC2292681.tar.gz
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['Jaws of Tenrec ecaudatus in lateral view.']
|
Figure 1 . These images demonstrate how adult size in an afrotherian may be reached in the absence of many permanent cheek tooth loci. The old individual above has its complete permanent dentition erupted, showing p4-m2 worn down to their roots (UMZC H5431J, image reversed). The individual below is larger, but retains its deciduous canine through dp4; their permanent successors plus m3 are still unerupted within the dentary (BMNH 70.3.10.4). Scale bar (in millimeters) applies to both specimens. The dotted line from the condyle to symphysis on the top specimen represents measure taken of maximum jaw length, quantified in Figure 2.
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yes
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PMC10368451
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Figure_3
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oa_package/37/45/PMC10368451.tar.gz
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['Muscle-Infiltrating CD226+ Cells are Predominantly Activated Effector CD4+ or CD8+ T CellsIn muscle biopsies from patients with DM and IMNM, CD226+ cells were diffusely distributed or were found in clusters, and they mainly consisted of CD4+ T cells, with a small amount of CD8+ T cells (A).', '31 Polychromatic immunofluorescence staining showed that most CD226+ cells were CD226+CD69+ or CD226+HLA-DR+ phenotypes (B), indicating CD226+ T cells are in an activated state in the muscle tissue of patients with IIM.', 'CD226+ Cells Were Mainly Activated Effector CD4+ or CD8+ T Cells(A) In the biopsies of patients with DM (n = 5) and IMNM (n = 3), CD226+ cells were strong coexpressed CD4 or CD8 cells.', 'As shown in C, the percentages of IFN- and TNF- production from CD4+CD226+ T cells were significantly higher than that from their CD226 counterparts in patients with DM (45.', '002 for TNF- ) (C).', '32,33 As shown in C, increased CD107a expression was observed on CD8+CD226+ T cells when compared with CD8+CD226- T cells in patients with DM (39.', 'Notably, few cells coexpressing CD226 and CD244 were found (D) in this study, highlighting CD226-expressing cells in muscle from patients with IIM as a new subset of activated cells distinct from CD28null cells.']
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Figure 3 CD226+ Cells Were Mainly Activated Effector CD4+ or CD8+ T Cells (A) In the biopsies of patients with DM (n = 5) and IMNM (n = 3), CD226+ cells were strong coexpressed CD4 or CD8 cells. (B) A representative staining from a patient with DM showed that most of the CD226+ cells were CD226+CD69 or CD226+HLA-DR+ phenotypes. (C) In PBMCs isolated from patients with DM, the production percentages of IFN- and TNF- of CD4 CD226+ T cells and CD107a expression percentages of CD8 CD226+ T cells were significantly higher than those of the CD226-negative counterparts in patients with DM (n = 5). (D) Costaining of CD226 and CD244 in the DM sections (n = 3) showed that the CD226+ cells did not colocalize with CD244+ cells. (A, B, and D, original magnification 400). * < 0.05, ** < 0.01, *** < 0.001. DM = dermatomyositis; IFN- = intracellular interferon-; IMNM = immune-mediated necrotizing myopathy; TNF- = tumor necrosis factor .
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yes
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PMC6986975
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Figure_7
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oa_package/d5/e4/PMC6986975.tar.gz
|
['However, it may be difficult to distinguish histologically between fibrous tumor capsule and intralesional fibrous band in small CNB samples ().', '.']
|
Fig. 7. Differential diagnosis of benign follicular nodule with a fibrous capsule (arrow) and follicular neoplasm (A). The specimen is composed of follicular proliferative lesion (right side), fibrous capsule (arrow), and adjacent normal thyroid parenchyma (left side). The morphology of follicular cell population within the nodule (C) is identical to that of the adjacent thyroid parenchyma (B). The specimen should be interpreted as benign follicular nodule based on differences in growth pattern of the follicular neoplasm compared with the surrounding thyroid parenchyma.
|
yes
|
PMC8606708
|
Figure_2
|
oa_package/ee/0a/PMC8606708.tar.gz
|
['All the deep and lateral surgical borders were free of malignancy [].', 'Interlaced fascicles of spindle-shaped cells with elongated (cigar-shaped) nuclei, some fields show atypical mitosis, others show wide areas of haemorrhage and necrosis.', '']
|
Fig. 2 Interlaced fascicles of spindle-shaped cells with elongated (cigar-shaped) nuclei, some fields show atypical mitosis, others show wide areas of haemorrhage and necrosis. (A) Hematoxylin & eosin, X40. (B)(C) Hematoxylin & eosin, X60. (D) Hematoxylin & eosin, X4.
|
yes
|
PMC8385474
|
Figure_1
|
oa_package/75/4e/PMC8385474.tar.gz
|
['Head MRI showing T1 and T2 weighted images.']
|
Figure 1 Head MRI showing T1 and T2 weighted images. A: T1 weighted image post gadolinium enhancement, axial plane: evidence of retinal detachment in the right eye globe centrally in the lower quadrants. B: T1 weighted image post gadolinium enhancement, axial plane: showing the extension of the retinal detachment posteriorly temporal in the upper quadrant with evidence of a nodular-like hyperintense lesion. Enhancement is extended more than the dimensions of the high signal lesion on T1 in the non-enhancing images. C: T1 weighted image without enhancement, axial plane: showing a hyperintense nodular-like lesion measuring 13 mm in its longitudinal axis and 5 mm in thickness. D: T1 weighted image post gadolinium enhancement, sagittal plane: showing the hyperintense nodular lesion in the temporal upper quadrant. E: T2 weighted image, axial plane: showing a nodular-like lesion of low signal. The arrow indicates melanoma location.
|
yes
|
PMC11612450
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Figure_5
|
oa_package/bf/53/PMC11612450.tar.gz
|
[' 5A,B), diminished mtDNA transcripts were evident in 12-month-old 3xTg mice, which experience age-associated changes (', ' 5C).', 'Allotropic lncMtDloop expression restores mitochondrial homeostasis in AD neurons.', 'Consequently, we delved deeper into the relationship between lncMtDloop and mtDNA levels.', ' 5D,E).', ' 5F).', ' 5G,H).', ' 5I M; Appendix Fig S6B; Movies EV1 3).', ' 5N P).', ' 5Q S).', ' 5T).', 'zip">Source data \n<media xlink:href="44318_2024_270_MOESM11_ESM.', ' 5.']
|
Figure 5 Allotropic expression restores mitochondrial homeostasis in AD neurons. ( ) RT-qPCR results illustrating mtRNA levels in the hippocampus and prefrontal cortex (PFC) of young (4 to 6 years) and old (16 to 20 years) . Error bars indicate meanSEM, with =45 per group, n.s. no significance, unpaired -test. ( ) RT-qPCR results depicting mtRNA levels in the hippocampus and PFC of young (3 months) and old wild-type mice (15 months). Error bars denote meanSEM, with =4 per group, n.s. no significance, unpaired -test. ( ) RT-qPCR analysis confirming RNA levels of mtRNA. Total RNAs were extracted from fresh hippocampal and PFC tissues of 12-month-old wild-type (WT) and 3xTg mice. Error bars represent meanSEM, with =6 mice per group, unpaired -test. ( ) qPCR results indicating mtDNA levels upon treatment with LV- in primary cultured neurons. Error bars denote meanSEM, with =56 repetitions per group, one-way ANOVA followed by Dunnetts multiple comparisons test. ( ) RT-qPCR results showing mtRNA levels following treatment with LV- in primary cultured neurons. Error bars signify meanSEM, with =46 per group, one-way ANOVA followed by Dunnetts multiple comparisons test. ( ) Relative mitochondrial RNA abundances quantified by RT-qPCR. RNA levels are normalized against WT control. Error bars represent meanSEM, with =68 repetitions per group, two-way ANOVA followed by Dunnetts multiple comparisons test. ( ) Western blot analysis depicting the levels of OXPHOS subunit proteins upon treatment with LV- in primary cultured neurons. ( ) Relative intensities of signals for OXPHOS subunit proteins. Error bars denote meanSEM, with =3 repetitions per group, one-way ANOVA followed by Dunnetts multiple comparisons test. ( ) STED imaging showcasing mitochondrial dynamics using MitoESq-635 staining. Scale bars, 1m. ( ) Mitochondrial fissions within 25% from the top (red) are termed peripheral fission. The mitochondria marked with a white arrow represent the morphology before and after peripheral fission. Scale bars, 2m. ( ) Peripheral fission rates in WT and AD neurons. Error bars indicate meanSEM, with =78 videos per group, two-way ANOVA followed by Tukeys multiple comparisons test. ( ) Mitochondrial fissions within the central 50% (green) are termed midzone fission. The mitochondria marked with a white arrow represent the morphology before and after midzone fission. Scale bars, 2m. ( ) Midzone fission rates in WT and AD neurons. Error bars indicate meanSEM, with =78 videos per group. For midzone fission rates: two-way ANOVA followed by Tukeys multiple comparisons test. ( ) Western blot analysis depicting the levels of Opa1 and Drp1 upon treatment with LV- in primary cultured neurons. ( , ) Relative intensities of signals for Opa1 and Drp1. Error bars denote meanSEM, with =4 repetitions per group, one-way ANOVA followed by Dunnetts multiple comparisons test. ( ) Assessment of mitochondrial oxygen consumption rate (OCR) in primary hippocampal neurons. 3xTg primary hippocampal neurons were infected with LV- or LV-control at DIV5 and subjected to seahorse assay at DIV14. Error bars denote meanSEM, with =8 repetitions per group, unpaired -test. ( , ) Restoration of resulted in increased reserved capacity and basal OCR levels in primary hippocampal neurons, as described above. Error bars represent meanSEM, =8 repetitions per group, unpaired -test. ( ) Influence of restoration on cytochrome c oxidase activity assessed using isolated mitochondria from primary cultured neurons as described above. Error bars denote meanSEM, =4 repetitions per group, one-way ANOVA followed by Dunnetts multiple comparisons test. .
|
yes
|
PMC6116098
|
Figure_4
|
oa_package/b5/22/PMC6116098.tar.gz
|
['An acute lateral patellar dislocation similarly provides an identifiable bone bruise\npattern, located at the inferomedial patella and lateral aspect of the lateral femoral\ncondyle ().', '10.', '1177_1941738118782453-fig4"/>Correlation with Chondral DamageSubchondral bone bruising at the time of acute ligamentous injury can lead to loss of\narticular cartilage and the development of focal OA.']
|
Figure 4. Acute lateral patellar dislocation. Magnetic resonance images (MRIs) demonstratingthe bony edema pattern on the inferomedial patella and lateral aspect of the lateralfemoral condyle. (a) T2-weighted axial MRI. (b) T2-weighted coronal MRI.
|
yes
|
PMC11358121
|
Figure_3
|
oa_package/3f/87/PMC11358121.tar.gz
|
['Sex differences in the histopathological analyses of lung tissue following 5 weeks HDM or PBS exposure.']
|
Figure 3 Sex differences in the histopathological analyses of lung tissue following 5 weeks HDM or PBS exposure. ( ) Histological images of lung tissues stained with Hematoxylin and eosin (HE) or Alcian Blue and Periodic Acid Schiff (AB-PAS) stains to show the degree of peribronchial and perivascular inflammation, inammation score, goblet cells, and hyperplasia. 10 magnication images showing lung tissues of PBS-treated and HDM-treated male and female (C57BL/6J) mice at 5 weeks and 72h of the study ( =4/group). ( ) Graphs representing Slide scoring for each of the groups. Data represented as meanSEM of 4 mice per treatment group. * ** .
|
yes
|
PMC10627867
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Figure_3
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oa_package/80/98/PMC10627867.tar.gz
|
['5-mm nonabsorbable suture anchor (SwiveLock; Arthrex) loaded with 2-mm collagen coated FiberTape (Arthrex) and 0 FiberWire (Arthrex) is placed at the UCL attachment at the sublime tubercle ().', 'Right medial elbow.']
|
Fig 3 Right medial elbow. A 3.5mm SwiveLock anchor (Arthrex) is inserted with 2-mm FiberTape (Arthrex) and FiberWire (Arthrex) at the distal insertion of the ulnar collateral ligament on the sublime tubercle. (ME, medial epicondyle.
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yes
|
PMC11346554
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Figure_1
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oa_package/99/55/PMC11346554.tar.gz
|
['.']
|
Figure 1. PAR2 external domain activation increases intestinal permeability and determines colitis severity. (a)- experimental design. SPF wild-type and protease-resistant PAR2 mutant (R38E-PAR2) mice were given 3.5% DSS in drinking water for 5days followed by water for the next 2days. Control mice received only water during the entire procedure. (b)- colonic intestinal barrier function represented as paracellular permeability (% hot sample/h/cm )and tissue conductance (ms/cm ) of mice after DSS or water control (n = 6-8). (c)- bacterial translocation into the spleen (CFU/g) of mice after DSS colitis or water control (n=4-9). (d)- spleen mass (mg) of mice after DSS colitis or water control (n=7-9). (e)- weight loss during DSS colitis or water control (n=8-9). (f)- colon length of mice after DSS colitis or water control (n=8-9). Percent colon length reduction relative to water treated controls is shown for each mouse strain. (n=8-9). (g)- stool index scored on a scale of 0-6 of mice after DSS colitis or water control (n=8-9). (h)- microscopic injury scoring of the colonic mucosa of mice after DSS colitis or water control (n=8-9). One representative image of the colon is shown for wild-type and R38E-PAR2 mice after DSS. Data are presented as mean where each dot represents an individual mouse(a-d, f-h) or where each dot represent the means.e.m. of the group (e). Displayed values were calculated by a one-way analysis of variance (ANOVA) with Tukeys post-hoc test. *p<0.05, **p<0.01, ***p<0.001, ****p<0.001.
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yes
|
PMC11440008
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Figure_2
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oa_package/4c/bb/PMC11440008.tar.gz
|
[' Scorestd drtPET/plainCT ceCTceCTDWIDefinitely normal1Faint uptake without CT findingNo abnormal enhancement on early and no defect on delayed imageNo signal intensity on any sequencesProbably normal2Focal uptake without CT findingEarly-enhanced wall thickening without defect on delayed imageNo SI on DWI but possible lesion on othersEquivocal3Faint or focal uptake with equivocal CT findingEarly-enhanced wall thickening with defect on delayed imageFaint or high SI on DWI but no possible lesion on othersProbably malignant4Faint uptake with definite Ct findingEarly-enhanced nodular lesion without defect on delayed imageFaint or definite high SI on DWI and equivocal on othersDefinitely malignant5Focal uptake with definite CT findingEarly-enhanced nodular lesion with defect on delayed imageFaint or definite high SI on DWI and definite lesion on othersInterpretation criteria of each modality.']
|
Figure 2 Interpretation criteria of each modality. ceCT: contrast-enhanced computed tomography, stdPET/CT: standard 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), drtPET/CT: diuretic FDG PET/CT, drtPET/ceCT: diuretic FDGPET/ceCT. The location of the region of interest (ROI)is identified byyellow arrows.
|
yes
|
PMC5265201
|
Figure_12
|
oa_package/a0/51/PMC5265201.tar.gz
|
[]
|
Fig. 12 Bronchiectasis due to usual interstitial pneumonia (UIP). Frontal chest x-ray showing prominent coarse interstitial and reticular opacities with a peripheral and basilar predominance, findings consistent with a UIP pattern of fibrosis. Axial CT imaging demonstrating the basilar-predominant varicoid traction bronchiectasis ( ) associated with honeycombing ( ) and subpleural reticulation
|
yes
|
PMC7863717
|
Figure_5
|
oa_package/67/4f/PMC7863717.tar.gz
|
['It is important to position the stent appropriately within in the portal vein, avoiding occlusion of intrahepatic portal branches ().', '\nFemale patient with locally advanced, inoperable pancreatic cancer.']
|
Figure 5 Female patient with locally advanced, inoperable pancreatic cancer. She underwent ERCP for the placement of a metal biliary stent, thereafter evolving to controlled hemorrhagic shock, followed by sepsis. Contrast-enhanced computed tomography of the abdomen and pelvis showed the proximal portion of the stent in the portal vein and its distal portion in the duodenum ( ). We simultaneously performed procedures for percutaneous drainage of biliary ducts, removal of the porto-duodenal stent by ERCP, and percutaneous portal angioplasty for occlusion of the porto-duodenal fistula ( ).
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yes
|
PMC9310836
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Figure_1
|
oa_package/55/d3/PMC9310836.tar.gz
|
['The extent of ISFN involvement in lymph nodes (LNs) removed from solid neoplasia surgery.']
|
Figure 1 The extent of ISFN involvement in lymph nodes (LNs) removed from solid neoplasia surgery. Variations of BCL2 staining in various LNs that show prominent ISFN involvement as defined above (see Figure for examples). The mean and range number of follicles involved by ISFN in each case are indicated. Case F has been excluded from the analysis as the slides available for research were not evaluable. Data includes only the LNs that show prominent ISFN involvement with at least one follicle displaying clustered or diffuse BCL2 positivity, and those with minimal involvement (few scattered strong BCL2positive cells in a germinal centre) are not included.
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yes
|
PMC5551999
|
Figure_4
|
oa_package/8b/1b/PMC5551999.tar.gz
|
['Subsequently, the proximal gastrohepatic trunk was embolized to its origin (', '']
|
Fig.4 Angiography from the celiac trunk after coiling of the gastrohepatic trunk, no longer showing contrast extravasation.
|
yes
|
PMC10628257
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Figure_1
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oa_package/6d/02/PMC10628257.tar.gz
|
[' 1A, Supplementary Tables S1 and S2).', ' 1B), and this is more frequent than previously reported (28%)12.', ' 1B).', ' 1B; Supplementary S1).', ' 1B).', ' 1C).', 'WES reveals the genomic landscape of 15 patients with PDTC and compares them with somatic mutation profiles from published studies.', 'Mutalisk18 was used to confirm the somatic mutation signatures in 15 patients with PDTC at Gil Medical Center (GMC).', ' 1B, the RAS (H/N/KRAS) genes are oncogenes, which are often mutated.', ' 1B, MAP2K2 is a gene that encodes mitogen-activated protein kinase kinase 2 (MEK2) and regulates cell growth and proliferation by phosphorylating ERK1/2 in the MAPK pathway, thereby activating it35.', ' 1B).', ' 1A and 3A).']
|
Figure 1 WES reveals the genomic landscape of 15 patients with PDTC and compares them with somatic mutation profiles from published studies. ( ) Number of somatic mutations in our patients with PDTC. The numbers of SNVs and INDELs for 15 patients with PDTC were depicted. ( ) Somatic mutation profiles and CNAs of our 15 patients with PDTC were in the left and right panels, respectively. Somatic mutation profiles of previously published studies in PDTC, FTC and PTC were in the middle panel. Genes on the Y-axis belongs to a curated gene set that is reportedly involved in major cancer pathways in thyroid cancer. Columns in the left and right panels refer to individual patients and those in the middle panel individual publications. ( ) The clinical information on the three subtypes for our 15 patients with PDTC is indicated.
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yes
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PMC7433935
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Figure_1
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oa_package/52/07/PMC7433935.tar.gz
|
['Scans were analyzed in the frontal, sagittal, and axial planes and skimmed three-dimensional (3D) reconstruction model [].', 'View of septa in all the planesLocalization of septa with respect to the wall of the sinusOrientation of septaMeasurement of heightMeasurement of the width of septa in five different areasThe data obtained were entered into Microsoft Excel spreadsheet, and statistical analysis was done.']
|
Figure 1 View of septa in all the planes
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yes
|
PMC11339653
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Figure_1
|
oa_package/52/7c/PMC11339653.tar.gz
|
['Therefore, CAG was performed and a diffuse ISR lesion on the BMS was confirmed (A).', 'However, 6 months later, the patient developed unstable angina pectoris (UAP) caused by a second episode of ISR in the SES in BMS (B).', 'Coronary angiography demonstrating occlusion of the proximal circumflex coronary artery and revascularization.', 'In February 2014, UAP recurred as a result of a third episode of ISR in the same lesion (C).', '72; D].', 'In November 2015, UAP occurred as a result of a fifth episode of ISR (E).', 'Coronary angiography was performed, which revealed a sixth episode of ISR (F).', 'Coronary angiography revealed a seventh ISR (G); PCI was performed using DCA followed by PCB (H) (Supplementary material).']
|
Figure 1 Coronary angiography demonstrating occlusion of the proximal circumflex coronary artery and revascularization. Occlusion of the proximal circumflex coronary artery and revascularization after percutaneous coronary intervention with a bare metal stent was performed. There were a total of six occurrences of in-stent restenosis. ( ) Coronary angiography showing the seventh in-stent occlusion of the same lesion ( ) and revascularization after performed percutaneous coronary intervention with directional coronary atherectomy and a drug-coated balloon ( ).
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yes
|
PMC7377108
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Figure_4
|
oa_package/65/92/PMC7377108.tar.gz
|
['.']
|
Figure 4. Moderate and high scores of survivin immunohistochemical expression. (A) Moderate expression, 60%; (B) moderate expression, 70%; and (C) high expression, 80%. Original magnification, 200.
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yes
|
PMC10479200
|
Figure_7
|
oa_package/aa/55/PMC10479200.tar.gz
|
['On post operative day #5, he underwent ERCP for removal of the remaining stent; cholangiogram showed no extravasation and normal caliber of the bile ducts ().', '.']
|
Figure 7. Balloon-occluded endoscopic cholangiogram demonstrating no contrast extravasation or fistulous track.
|
yes
|
PMC10669014
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Figure_1
|
oa_package/4a/cb/PMC10669014.tar.gz
|
['Bone Loss ChallengeCritical-sized bone defects () caused by nonunion, trauma, infection, malignancy, spine pseudoarthrosis, and osteolysis pose complex reconstructive challenges for orthopedic surgeons.', '00129107477Radiograph of a tibial critical-sized bone defect associated with a fracture nonunion complicated by infection.']
|
Figure 1 Radiograph of a tibial critical-sized bone defect associated with a fracture nonunion complicated by infection. The patient status is post-placement of an external fixator with an intramedullary antibiotic device pending distraction osteogenesis (Radiographs courtesy of Dr Joseph Patterson).
|
yes
|
PMC9293091
|
Figure_7
|
oa_package/3b/14/PMC9293091.tar.gz
|
['Mycosis fungoides variant: granulomatous slack skin.']
|
Figure 7 Mycosis fungoides variant: granulomatous slack skin. Large, slack, partially pendulous, erythematousviolaceous plaque in the right inguinal region, extending over the right hip and buttock.
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yes
|
PMC9500331
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Figure_2
|
oa_package/20/d8/PMC9500331.tar.gz
|
['MI: Myocardial infarction, H E: Hematoxylin and eosin stainingAcute MI: pathology appearance consistent with 1-3 days (H E, 100).']
|
Figure 2 Acute MI: pathology appearance consistent with 1-3 days (H&E, 100). MI: Myocardial infarction, H&E: Hematoxylin and eosin staining
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yes
|
PMC9382218
|
Figure_3
|
oa_package/e6/54/PMC9382218.tar.gz
|
[]
|
FIGURE 3 PET/CT showed a thickening of the distal sigmoid colon and distant lymph nodes in the left supraclavicular region.
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yes
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PMC6258882
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Figure_1
|
oa_package/43/a5/PMC6258882.tar.gz
|
[]
|
FIGURE 1 An example of masks of the global WM (red) and ROI, including the splenium (light blue) and genu (purple) of the corpus callosum, superior longitudinal fasciculus (yellow), minor forceps (green), and major forceps (dark blue) on axial T -weighted anatomical image of Participant 1.
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yes
|
PMC7759176
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Figure_1
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oa_package/8d/ee/PMC7759176.tar.gz
|
['The lesion measured 50 mm 29 mm 26 mm [a].', 'Complete excision of the mass with partial cystectomy was performed [b].', '(a) Sagittal and coronal section of computed tomography scan showing the bladder mass at the dome extending into the abdominal muscles.']
|
Figure 1 (a) Sagittal and coronal section of computed tomography scan showing the bladder mass at the dome extending into the abdominal muscles. (b) Left image showing a large cystic mass in the abdominal muscles. Middle image showing intravesical mass. Right image depicting the excised tumor with cesarean section scar
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yes
|
PMC10587792
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Figure_9
|
oa_package/8b/97/PMC10587792.tar.gz
|
['Nuclear medicine used for the detection of various diseases.']
|
Figure 9 Nuclear medicine used for the detection of various diseases. SPECT: single photon emission computed tomography, CT: computed tomography, PET:positron emission tomography.
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yes
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PMC6470242
|
Figure_2
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oa_package/68/1e/PMC6470242.tar.gz
|
[' 2): first, a spontaneous separation of the coronary arterial wall caused by an intimal tear and resulting in medial dissection, haemorrhage and subsequently the formation of a false lumen [15, 16]; second and less often, haematoma formation in the media causing separation of two arterial layers and, thereby, leading to the formation of a false lumen and dissection of the true lumen [15, 16].', 'Schematic figure of the two proposed mechanisms of spontaneous coronary artery dissection, a Normal artery, b intraluminal haemorrhage, c intimal tear.', '[15])Triggers for spontaneous coronary artery dissectionMost cases of SCAD occur in previously healthy young women.']
|
Fig. 2 Schematic figure of the two proposed mechanisms of spontaneous coronary artery dissection, Normal artery, intraluminal haemorrhage, intimal tear. (From Saw etal. [ ])
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yes
|
PMC7472569
|
Figure_3
|
oa_package/33/67/PMC7472569.tar.gz
|
['The pre-treatment dosage regimen of melatonin attenuated MCAO-mediated stress associated MAPK p-P38/p-JNK pathways (\nA\n).', 'Moreover, immunohistochemical results validated our Western findings (\nB\n).', '\n(A) The immunoblot results of p-P38, total P-38, p-JNK, and total JNK from the ipsilateral cortex and striatum following MCAO.']
|
Figure 3 The immunoblot results of p-P38, total P-38, p-JNK, and total JNK from the ipsilateral cortex and striatum following MCAO. The immunoblot bands were quantified using ImageJ software, and the statistical differences are indicated in the corresponding graphs. The data are expressed as the mean SEM for n = 6 rats/group, and the number of experiments = 3. -Actin was used as a control. Data were analyzed by two-way ANOVA followed by post-hoc Bonferroni Multiple Comparison test using graph-pad prism-5 software. The brain tissue for Western blot was collected after 24h of vehicle or melatonin treatment and stored at 80C until used. Symbol or showing significant difference relative to vehicle operated sham group and their values are p < 0.001 or p < 0.01 respectively, while # showing significant difference values of p < 0.05 relative to MCAO group. The presented images indicated Immunoreactivity of p-JNK in the cortical and striatum tissue of rat brain. The p-JNK exhibits cytoplasmic localization. The data are expressed as the mean SEM for n = 5 rats/group, and the number of experiments = 3. Scale bar = 50 m, magnification 40. The immunohistochemistry slides were processed from the stained TTC coronal sections after fixation in 4% paraformaldehyde. From the thick coronal TTC sections, paraffin blocks were made, and later 4-m-thin coronal sections were prepared by a rotary microtome. The symbol showing significant difference relative to the vehicle operated sham group and the value is p < 0.00, while # showing significant difference value of p<0.05 relative to the MCAO group. p-JNK, phospho c-Jun N-terminal kinase; JNK, c-Jun N-terminal kinase; p-P38, phospho-P38.
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yes
|
PMC10772341
|
Figure_3
|
oa_package/91/b7/PMC10772341.tar.gz
|
[':The LGA emerge independently cranial to the origin of the CHA and SA, but the CHA and SA both originate independently at the same level on the left and right anterolateral sides of the aorta, respectively.']
|
Fig. 3 A 3D reconstruction illustrating the origins of the LGA from the abdominal aorta proximal to the origins of the CHA and SA (A); the origins of the CHA and SA from the abdominal aorta, both at the same level and independently (B). CHA, common hepatic artery; LGA, left gastric artery; SA, splenic artery.
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yes
|
PMC10972650
|
Figure_4
|
oa_package/93/df/PMC10972650.tar.gz
|
['org/1999/xlink" xlink:href="10-1055-s-0043-1777355-i2382906-3"/>\nEndometrial biopsy of a 61-year-old female with postmenopausal bleeding showed high-grade serous carcinoma.']
|
Fig. 4 Endometrial biopsy of a 61-year-old female with postmenopausal bleeding showed high-grade serous carcinoma. Magnetic resonance imaging (MRI) high-resolution T2 weighted ( ) sagittal and ( ) coronal and ( ) diffusion-weighted imaging showed a heterogeneous diffusion restricting growth within the endometrial cavity infiltrating less than 50% of the myometrial thickness in the left side of the fundus of the uterus (arrowheads in b,c,d). MRI was reported as International Federation of Gynecology and Obstetrics (FIGO) 1A endometrial cancer according to the 2009 FIGO staging system. Given the nonendometroid or an aggressive histological type and myometrial infiltration, according to the new 2023 FIGO staging system, this patient would be staged as FIGO IIC endometrial carcinoma. Also, note the multiple classical intramural fibroids.
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yes
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PMC11439839
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Figure_2
|
oa_package/08/ac/PMC11439839.tar.gz
|
['Four years after repair, imaging revealed a type II endoleak (Fig 2) that was surveilled with annual computed tomography (CT) angiogram.', 'Fig 2Computed tomography (CT) angiogram showing axial view of type II endoleak after endovascular aneurysm repair (EVAR).']
|
Fig2 Computed tomography (CT) angiogram showing axial view of type II endoleak after endovascular aneurysm repair (EVAR).
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yes
|
PMC9860450
|
Figure_1
|
oa_package/dc/32/PMC9860450.tar.gz
|
['Diagnostic assessmentWe performed a CT scan of the right ankle which showed a fracture line gap in the neck of the tallus (Hawkins fracture type III) and a fracture of the medial malleolus with no sign of soft callus (A, B).', 'Preoperative CT-Scan of the right ankle: a fracture line gap in the neck of tallus (Hawkins fracture type III) and a fracture of the medial malleolus with no sign of soft callus (A) Lateral view (B) posterior view.', 'Therapeutic interventionWe performed an open reduction and internal fixation (ORIF) with bone graft to treat nonunion talar neck fracture.']
|
Fig. 1 Preoperative CT-Scan of the right ankle: a fracture line gap in the neck of tallus (Hawkins fracture type III) and a fracture of the medial malleolus with no sign of soft callus (A) Lateral view (B) posterior view.
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yes
|
PMC4275788
|
Figure_5
|
oa_package/2c/62/PMC4275788.tar.gz
|
['The mass did not incorporate the valve or the myocardium and had the appearance of multiple rubbery cystic clusters pedunculated on a stalk emanating from the hepatic vein ().', 'Gross architecture of atrial mass.']
|
Fig. 4 CT scan of cardiac metastases. CT scan of the chest demonstrates (A) the presence of tumor in the main pulmonary artery on axial section (via extension of the right ventricular mass through the pulmonic valve); and (B) tumor extension into the IVC and right atrium on coronal section. White arrow indicates tumor originating from the left hepatic vein (only remaining hepatic vein after right trisectionectomy).
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yes
|
PMC6079308
|
Figure_3
|
oa_package/25/df/PMC6079308.tar.gz
|
['A positive immunohistochemical staining for inhibin was the key point of this diagnostic feature ().', 'Histologic findings showed granulosa cell with ovoid nuclei and nuclear grooven with microfollicular pattern /HE*100MAGNIFIED 100 TIMES.']
|
Figure 3 Histologic findings showed granulosa cell with ovoid nuclei and nuclear grooven with microfollicular pattern /HE*100MAGNIFIED 100 TIMES.
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yes
|
PMC4330613
|
Figure_1
|
oa_package/a0/1a/PMC4330613.tar.gz
|
['\nData collectionDental patterns were classified into nine types which were commonly observed in dental radiography and converted into a consistent set of codes [].', 'Panoramic radiograph with suitable annotations (commonly observed dental pattern)Table 1Classified dental patterns seen in orthopantomograms and corresponding codesResultsDiversity of dental patterns observed for full dentition, maxilla, and mandible were found to be 99.']
|
Figure 1 Panoramic radiograph with suitable annotations (commonly observed dental pattern)
|
yes
|
PMC6287230
|
Figure_3
|
oa_package/9e/86/PMC6287230.tar.gz
|
['Magnetic resonance imaging (MRI) of the right knee demonstrated a moderate knee effusion with a large popliteal cyst, reactive synovitis, and internal debris posteriorly, suggesting the possibility of PVNS [13] (', ' 3(a-c) T2 weighted MRI images of the sagittal, anterior coronal, and posterior coronal views of the right knee demonstrating a moderate knee effusion (left arrow in panel a, arrows in panel b) with a large popliteal cyst and internal debris posteriorly (right arrow in panel a, arrows in panel c).']
|
Figure3 (a-c) T2 weighted MRI images of the sagittal, anterior coronal, and posterior coronal views of the right knee demonstrating a moderate knee effusion (left arrow in panel a, arrows in panel b) with a large popliteal cyst and internal debris posteriorly (right arrow in panel a, arrows in panel c).
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yes
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PMC9474463
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Figure_1
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oa_package/0b/50/PMC9474463.tar.gz
|
[' 1).', 'Concentrically reduced humeral head in the A.', ')The degree of fragment dislocation was usually not a decisive criterion for either operative or non-operative treatment because no clear rules are provided within the literature.']
|
Fig. 1 Concentrically reduced humeral head in the A.P.-radiograph is the main prerequisite for nonoperative treatment of GRF and represents the main criterion within radiographic controls ( CT en face view; A.P.)
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yes
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PMC10024931
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Figure_3
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oa_package/73/dc/PMC10024931.tar.gz
|
['Pulmonic valve mass on follow-up transthoracic echocardiogram (parasternal short axis right ventricle outflow view)DiscussionPrimary cardiac tumors are rare.']
|
Figure 2 Transgastric right ventricle outflow view on transesophageal echocardiogram. No significant systolic flow acceleration on the color doppler (left panel). Suspected myxoma on the pulmonic valve leaflet (red arrows)
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yes
|
PMC6040560
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Figure_1
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oa_package/7f/8a/PMC6040560.tar.gz
|
['9 U/mL); the curve of insulin, C-peptide and glucose changes were shown in figure 1.', 'Postsurgical histopathology confirmed rectum neuroendocrine tumour resected in 2010.']
|
Figure 1 Postsurgical histopathology confirmed rectum neuroendocrinetumour resected in 2010. (A) H&E staining, (B) Syn(Synaptophysin), (C)Ki-67<2%.
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yes
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PMC10654273
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Figure_2
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oa_package/7a/ef/PMC10654273.tar.gz
|
['2A and B.', ' 2C.', '2G, pure alginate-based ink can be seen with air bubbles and some surface roughness.', '2H.', 'This is not the case in ', '2I, where the t-ZnO particles shadow each other.', 'Morphological, structural and chemical analysis of the tetrapodal zinc oxide.', 'The tetrapodal arms sticking out of the dried hydrogel can be clearly observed for K (5% t-ZnO) and L (15% t-ZnO)Crystal structure of t-ZnOIn order to investigate the degree of crystallinity of the t-ZnO, XRD measurements on the powdered material was performed.']
|
Fig. 2 Morphological, structural and chemical analysis of the tetrapodal zinc oxide. and SEM micrograph of the tetrapods. The four arms protruding at fixed angles are visible in A, the hexagonal shape of each arm is visible in B. A photograph of the t-ZnO powder. Micro-Raman spectrum of alginate, zinc oxide and composites of 5% and 15% t-ZnO in alginate. Enlarged micro-Raman spectrum of t-ZnO. Some characteristic peaks are marked with read lines and their corresponding wavenumber. Diffractogram of the t-ZnO powder. The reflexes found indicate the crystallinity of the t-ZnO. Optical micrographs of alginate-based inks with concentrations of 0%, 5% and 15% t-ZnO. SEM micrographs of the alginate-based inks after lyophilization. The tetrapodal arms sticking out of the dried hydrogel can be clearly observed for K (5% t-ZnO) and L (15% t-ZnO)
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yes
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PMC9403561
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Figure_3
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oa_package/67/54/PMC9403561.tar.gz
|
['The Raman map in a and b and the corresponding Raman image analysis (', '3c), as well as LC-MS results (d) of TG, showed similar changes to cholesterol with an increased level in PE/PSS compared to the control group.', 'However, Phosphatidylcholine (PC) (e h) and Phosphatidylserine (PS) (', 'Raman imaging comparison to LC-MS data for triglyceride (TG), phosphatidylcholine (PC), and phosphatidylserine (PS).', 'We observed trends in the LC-MS data towards a reduction in total lipid species, not including CHOL, ChE, or TG (p = .']
|
Fig. 3 Raman imaging comparison to LC-MS data for triglyceride (TG), phosphatidylcholine (PC), and phosphatidylserine (PS). a,b) Raman heatmap for TG for control and PE/PSS. c) quantification of Raman heatmap for TG. d) LC-MS data for TG. e, f) Raman heatmap for PC for control and PE/PSS. g) Quantification of Raman heatmap for PC. h) LC-MS data for PC. i, j) Raman heatmap for PS for control and PE/PSS. k) Quantification of Raman heatmap for PS. l) LC-MS data for PS. In all of the Raman maps, the colorbar represents the correlation coefficient and the scalebar=1mm.
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yes
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PMC9478670
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Figure_4
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oa_package/a5/86/PMC9478670.tar.gz
|
['Histology of affected bone is shown in ', ' 3', ' 3, ', 'On histology, a low-power view shows a thinned cortex and trabeculae and a lack of trabecular interconnections (', ' 3, ']
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Fig.4 This bone section demonstrates marked thinning of the cortex (arrowhead) and trabeculae. Trabecular interconnections are significantly diminished. (H&E, low-power magnification).
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yes
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PMC6548814
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Figure_2
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oa_package/b2/4a/PMC6548814.tar.gz
|
['Here, we will summarize selected IgE-independent mast cell activation pathways which may be related to allergic asthma ().', 'Lung mast cells can be activated by many kinds of stimuli.']
|
Figure 2 Lung mast cells can be activated by many kinds of stimuli. IgE/antigen-mediated activation of FcRI triggers exocytosis of granular compounds, a rapid generation and release of lipid mediators such as leukotrienes and prostaglandins and the synthesis and release of cytokines and chemokines, which occurs hours after the activation event. Mast cell activation via MRGPRX2, the adenosine A3 receptor, and the ATP receptor P2X also triggers release of all three types of mast cell-derived compounds. Activation via TLRs generally triggers synthesis and release of cytokines and chemokines, and some TLRs may also trigger release of lipid mediators. However, this mode of mast cell activation does not induce degranulation. IL-33, which activates the ST2 receptor complex potentiates IgE/antigen-mediated degranulation in human mast cells but not in mouse mast cells. Alone, IL-33 triggers synthesis and release of cytokines and chemokines. In mice, TSLP acting via TSLPR promotes mast cell development, whereas in human mast cells TSLP potentiates IL-33-stimulated secretion of type 2 cytokines and chemokines.
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yes
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PMC7555424
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Figure_5
|
oa_package/ec/81/PMC7555424.tar.gz
|
['The 5/6Nx group shows a permanent reduction in ATP synthase activity (A), together with a reduction in m in S3 at all evaluated time points (B), which agrees with the reduction in P values (B).', 'Furthermore, the 5/6Nx group shows a permanent reduction since day 2 in CI activity (C) and a decrease in complex III (CIII) activity on days 7, 14, and 28 after surgery (F).', 'However, no changes were found in the evaluated times in complex II (CII, D) and complex IV (CIV, F) activities with respect to the Sham group.', 'Thus, the lower m (B) results in lower ATP synthase activity (A).', 'This reduction in m can be attributable to CI activity reduction observed since day 2 (C), but also to the posterior decrease in CIII activity observed since day 7 (E), implying that CI impairment precedes CIII impairment.', 'However, at early times, namely on days 1, 10, and 14 of nephrectomy, studies did not find increase in mtDNA, in mtRNA, in mitochondrial complexes subunit levels, or in levels of transporters [19,20,22,24,42], which may suggest that the observed complexes activities reduction (C,E) is not linked to mitochondrial biogenesis reduction at the early stage.', 'Changes in oxidative phosphorylation (OXPHOS) system elements and membrane potential ( m).']
|
Figure 5 Changes in oxidative phosphorylation (OXPHOS) system elements and membrane potential (m). ( ) ATP synthase activity. ( ) Change in m in state 3 (S3) and m in state 4 induced by oligomycin (S4o). ( ) Complex I (CI); ( ) complex II (CII); ( ) complex III (CIII); and ( ) complex IV (IV). Data are mean SEM, = 47. * < 0.05, ** < 0.01, and *** < 0.001 vs. Sham, Dunnett test. d = days after nephrectomy surgery, Sham = simulated operation-control group; 5/6Nx= 5/6 nephrectomy.
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yes
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PMC3969051
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Figure_5
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oa_package/31/e3/PMC3969051.tar.gz
|
['Inflammatory process in the tendon sheath (tenosynovitis) presents similarly an inflammation in the joint capsule synovial thickening, increased vascularization, frequently accompanied by exudation [11] ().', 'Inflammation of the synovial sheath of the fourth extensor compartment.']
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Figure 5 Inflammation of the synovial sheath of the fourth extensor compartment.
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yes
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PMC9381707
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Figure_5
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oa_package/54/02/PMC9381707.tar.gz
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['Given that NMJ pathology is another readout for assessing the degeneration of the neuromuscular system in the Smn2B/ mice, we quantified neurofilament accumulation and NMJ denervation ().', 'Genetic ablation of necroptotic cell death pathways does not improve NMJ pathology in Smn2B/ mice.']
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Figure 5 Genetic ablation of necroptotic cell death pathways does not improve NMJ pathology in mice. Representative immunofluorescent images of the (TVA) muscle stained with bungarotoxin (BTX; red) and for neurofilament (NF; green) and synaptic vesicle protein 2 (SV2; green). Quantification for NF accumulation and denervation in NMJs from P19 mice. White arrows show NF accumulation in and end plate denervation in . Scale bars = 20 m. = 46 per genotype. Data represent mean SEM. An ordinary one-way ANOVA with Tukey test for multiple comparison. ns, non-significant. < 0.001 for **, and < 0.0001 for ****.
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yes
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PMC8898071
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Figure_2
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oa_package/94/1f/PMC8898071.tar.gz
|
['A 41-year-old, asymptomatic woman with Mazabraud s and McCune Albright syndromes with an incidental intercostal intramuscular myxoma.']
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Figure 2 A 41-year-old, asymptomatic woman with Mazabrauds and McCune Albright syndromes with an incidental intercostal intramuscular myxoma. Cross-sectional imaging demonstrating polyostotic fibrous dysplasia (A) Axial T2-weighted MR image of the chest shows hyperintensity and expansion (arrow) within the eighth posterior right rib. (B) The follow-up axial image from CT of the chest shows a well-defined expansile, cystic lesion (arrow) within the eighth posterior right rib. (C) The sagittal image from CT of the neck shows multifocal sclerotic and cystic changes notably involving the occipital bone (arrow), consistent with the patients known history of polyostotic fibrous dysplasia.
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yes
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PMC3085152
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Figure_4
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oa_package/95/4d/PMC3085152.tar.gz
|
['Histopathological examination revealed partial to full thickness replacement of conjunctival epithelium by dysplastic squamous cells, intact basement membrane, and an abrupt transition between the normal conjunctiva and the dysplastic area [].', 'Well-defined limbal OSSN encroaching over the cornea with gelatinous surface (A).']
|
Figure 4 Well-defined limbal OSSN encroaching over the cornea with gelatinous surface (A). Replacement of conjunctival epithelium by dysplastic squamous cells, thickening, and keratinization of superficial cells (atypia) (B). Sudden transition between normal and dysplastic area (arrow) with intact basement membrane (C). (B and C) H and E, 25)
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yes
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PMC11439839
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Figure_1
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oa_package/08/ac/PMC11439839.tar.gz
|
['Her past surgical history was significant for an infrarenal abdominal aortic aneurysm that was repaired 4 years prior with an Endurant II Stent Graft System (Medtronic, Dublin, Ireland) (Fig 1).', 'Fig 1Initial computed tomography (CT) angiogram showing axial (A) and coronal (B) views on first follow-up CT scan after endovascular aneurysm repair (EVAR).']
|
Fig1 Initial computed tomography (CT) angiogram showing axial and coronal views on first follow-up CT scan after endovascular aneurysm repair (EVAR).
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yes
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PMC5467421
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Figure_3
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oa_package/9b/3d/PMC5467421.tar.gz
|
['.']
|
Fig. 3. Looking into the peritrochanteric space from the viewing portal of this left hip, a complete tear of the gluteus medius from the lateral facet is identified. (A) A grasper retracts the tendon proximally exposing the bony footprint. (B) The tendon is mobilized distally over the insertion site. (C) The anterior of two double-loaded suture anchors is being inserted in the proximal portion of the bony footprint. (D) A second, more posterior, anchor is being inserted. The colored sutures of the anterior anchor are seen emerging from the anchor hole (arrows); these have already been passed in a mattress fashion through the proximal tendon. (E) The four sutures from the two double-loaded anchors have been tied, leaving one suture limb from each knot to be incorporated into the distal fixation. (F) A distal knotless anchor device is driven into place, incorporating two suture limbs from the proximal knots. (G) The final repair construct is inspected with secure double row fixation.
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yes
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PMC7694716
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Figure_6
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oa_package/d9/32/PMC7694716.tar.gz
|
['(A-F)Are the Ultrasound (US) images (A B), IOTA two-step alternative two-step analysis (C-E) and final histopathology (F) in a 60 year old female with pelvic mass and abdominal distension.']
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Figure 6( Are the Ultrasound (US) images (A & B), IOTA two-step & alternative two-step analysis (C-E) and final histopathology (F) in a 60 year old female with pelvic mass and abdominal distension. Grey-scale US (A): Large cystic mass, with multiple papillary projections (red arrows). Color Doppler (B): Central vascularity (green arrow) consistent with a color score 4. Two-step analysis tabulated in (C) and (D): malignant diagnosis. Alternative two-step analysis tabulated in (E): Very high risk. Histopathology (F) confirms the US diagnosis of mucinous adenocarcinoma.
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yes
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PMC10866662
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Figure_6
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oa_package/af/86/PMC10866662.tar.gz
|
['Sebaceous glands, which still expressed their differentiation marker SCD1, were markedly diminished (, C and D, and Supplemental 0F).', 'Eccrine sweat gland numbers in footpads were strongly reduced in K14Cre+Kctd1fl/flKctd15fl/fl mice, consistent with the reported anhidrosis in SEN syndrome patients (D).', 'This supports our finding of reduced sebaceous glands in K14Cre+Kctd1fl/flKctd15fl/fl mice but not of a sebocyte differentiation block, as immunolabeling for the sebocyte differentiation marker SCD1 was observed in smaller sebaceous glands of these mice (C).', 'KCTD1/KCTD15 complexes in keratinocytes are required for the proper formation of skin appendages.']
|
Figure 6 KCTD1/KCTD15 complexes in keratinocytes are required for the proper formation of skin appendages. ( ) Immunolabeling for active -catenin of P4 back skin in mice and WT mice shows abnormal and shorter hair follicles in the mutant mice. Foxi3 is localized at the isthmus/infundibulum junction of hair follicles at P4 (arrows). ILB4, isolectin B4. Scale bars: 100 m (top); 50 m (middle and bottom). ( ) Top 2 rows: Reduced hairs and abnormal hair follicles (red arrows) with flattened scale/interscale junctions (black arrows) in 3-week-old tail skin of mice. Scale bars: 250 m. Bottom 2 rows: Abnormal hairs and reduced sebaceous glands in tail skins of 8-month-old mice, with increased Krt6a in the interfollicular epidermis. Scale bars: 10 m. ( ) Left: SCD1 immunolabeling of back skin of adult mice (DKO) and littermate controls. Scale bars, 20 m. Right: RNA-Seq values ( = 3 per group) for expression in P4 back skin of DKO versus control mice. Mean SEM; adjusted value. ( ) Oil Red O and Nile blue staining of footpad skin from adult mice shows diminished sebaceous glands (orange, white arrows) and loss of eccrine sweat glands (red arrows) compared with WT controls. Quantification of Oil Red O hind paw area (sebaceous glands) in 7-week-old male mice (DKO) and littermate controls. Eccrine gland duct numbers for each footpad (FP1 to FP6) of these mice are shown. Mean SEM; values (2-tailed test; = 3 mice per group).
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yes
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PMC4460127
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Figure_1
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oa_package/72/19/PMC4460127.tar.gz
|
['In Sca-1-EGFP transgenic mice, EGFP expression was prominently detected in tubular epithelium of proximal tubules (A 1C), loop of Henle (<xref rid="pone.', 'Similar results were obtained using a Sca-1 antibody (D 1F, and data not shown), which also revealed the apical localization of Sca-1 protein on proximal tubular cells (<xref rid="pone.', 'g001" ref-type="fig">D 1F).', 'g001Sca-1 expression in adult renal epithelial cells.']
|
10.1371/journal.pone.0129561.g001
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yes
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PMC6714522
|
Figure_15
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oa_package/24/c5/PMC6714522.tar.gz
|
[]
|
Fig 15 Viewing from the posterior portal and looking anteriorly in the lateral decubitus position in a right (R) shoulder, 1 limb of the suture has been placed through the superior labrum, exiting superiorly. The suturing device is placed through the anterior-superior portal, and the labrum is pierced approximately 1cm posterior to the first suture limb.
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yes
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PMC3970802
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Figure_4
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oa_package/db/a3/PMC3970802.tar.gz
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['323/fig-4Foci forming analysis of the CT2AXH region.']
|
10.7717/peerj.323/fig-4
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yes
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PMC8177683
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Figure_5
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oa_package/e7/d8/PMC8177683.tar.gz
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['Loss of tissue enhancement is a strong sign of necrosis ().', 'Mucormycosis with orbital and brain involvement.']
|
Figure 5 Mucormycosis with orbital and brain involvement. : Axial T2-weighted MRI sequence showing a hyperintense lesion, a hypointense peripheral halo (arrow), and pronounced peripheral edema. : Contrastenhanced coronal T1-weighted sequence showing a heterogeneous lesion in the right orbital region. Black turbinate sign (thin arrow), characterized by a lack of enhancement of the nasal turbinate mucosa. There is also leptomeningeal enhancement on the affected side (thick arrow).
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yes
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PMC10435852
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Figure_2
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oa_package/45/18/PMC10435852.tar.gz
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['Differentiation of hiPSCs into myotubes skeletal muscle cellshiPSC clones from Control and R155H/+ groups (for a total number of 8 lines) were differentiated into skeletal muscle following a multi-step schematic protocol that included transduction of the hiPSCs with an inducible PAX7 expression, Embryoid Bodies (EBs) formation, purification, and expansion of myogenic precursors, and finally the formation of the multinucleated muscle fibers or myotubes (A) (20).', 'Diseased and isogenic control iPSCs were successfully differentiated into myoblast expressing PAX7 (GFP+ cells), CD29, and alpha-7 integrin (s 2B,C).', 'Further differentiation was performed to generate multinucleated myofibers expressing skeletal muscle marker MHC (D).', 'Differentiation of hiPSC into skeletal muscle fibers via expressing PAX7.', 'Our results reveal that p97/VCPR155H +/ myoblasts had lower expression of PAX3 and MYF5 than controls and that p97/VCPR155H +/ myotubes had a significative lower expression of MYOD1 (E).', 'MYOD remained unchanged (s 2F,G).', 'The proteins MYF5 (28KDa) and MYOD1 (35KDa) are shown in cropped blot images (s 2F,G), and their corresponding full-length blot images are shown as well (Supplementary s S5A,B).']
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Figure 2 Differentiation of hiPSC into skeletal muscle fibers via expressing PAX7. Schematic representation of skeletal muscle differentiation protocol and terminal differentiation of skeletal muscle cells into myotubes. Representative FACS profile of PAX7-induced proliferating myogenic progenitors. Group 1 myoblasts were previously purified by FACS selection of only GFP-positive (PAX7 ) cells and then expanded. After 1week of expansion, the myogenic precursors were stained for two early skeletal muscle markers, Alpha 7 integrin and CD29. The percentage indicates cells staining positive for GFP, Alpha 7 Integrin, and CD29. SSC side scatter. Myogenic progenitors were differentiated into myotubes over 68days, and immunofluorescence determined the myotube formation. Blue nuclei as stained with Hoechst. Red, Myosin Heavy Chain (MHC), myotubes; Scale Barr 400nm. qRT-PCR of Group 1 myoblast and myotubes, showing expression of PAX3, MYF5 (Marker of myogenic precursors: myoblasts), MYOD1, and MYOGENIN (Late marker of terminally differentiated skeletal muscle cells). Western Blot analysis for the expression analysis and quantification of the proteins Myf5 (28KDa) and MyoD1 (35KDa) in myoblasts and myotubes , where are showed the cropped blot images . Their corresponding uncropped full-length blot images are also represented ( ).
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yes
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PMC8328424
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Figure_1
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oa_package/f3/1f/PMC8328424.tar.gz
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[]
|
Figure1 CT scanning of a case shows the lesion closely related to segmental bronchi.
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yes
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PMC10827550
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Figure_4
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oa_package/e4/bc/PMC10827550.tar.gz
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['Angiographic image of cobra catheter within the right hepatic artery with arrow demonstrating a well-defined rounded opacity arising from the cystic artery consistent with a pseudoaneurysm .', ':Another important potential complication of utmost concern regarding cystic artery coil embolization is gall bladder ischemia.']
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Fig. 4 Angiographic image of cobra catheter within the right hepatic artery with arrow demonstrating a well-defined rounded opacity arising from the cystic artery consistent with a pseudoaneurysm .
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yes
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PMC9537733
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Figure_2
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oa_package/23/2a/PMC9537733.tar.gz
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['SS1">Heterologous vaccine efficacyThe heterologous vaccine efficacy of Prevacent was determined in three ways: (i) clinical signs including rectal temperatures, (ii) PRRSV loads in nasal swabs and serum were assessed at 0, 7, and 14 dpc (); and (iii) viral loads, and the lungs were macroscopically assessed at necropsy and sent for microscopic examination (14 dpc, ).', 'Rectal temperatures varied between groups (A): only the NC174- and NADC20-CHA pigs exhibited increased temperatures at 7 dpc.', 'Pre-challenge viral load analysis at 0 dpc showed that all Prevacent-VAC animals had similar PRRSV viral copy numbers: this confirms that Prevacent vaccination was not only successful but also homogenous (B).', 'For VR2332 and NADC30, Prevacent vaccination significantly reduced viremia at both time points; for NADC30, it reduced viremia at 14 dpc (B).', 'In VR2332-CHA pigs, viral loads in nasal swabs were either low ( 104 genomic copy number/ml in 4/12 pigs) or completely absent (8/12 pigs; C).', 'In contrast, challenge with the other PRRSV strains led to considerably higher viral loads in nasal swabs of all inoculated animals (include mean genomic copy number range; C).', 'Prevacent vaccination successfully induced viremia at 4 weeks post vaccination (=0 dpc, B).', 'In contrast, at this pre-challenge time point, nasal swabs from all pigs were negative for PRRSV (C).', 'Fever was solely induced at 7 dpc and by only two PRRSV strains NC174 and NADC20 (A).', 'While the MOCK-CHA groups showed no to minimal lung gross abnormalities (B), the median histopathology scores were between one and two.']
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FIGURE 2 Heterologous vaccine efficacy of Prevacentrectal temperatures, viremia, and viral loads in nasal swabs. Rectal temperatures , viremia , and viral loads in nasal swabs were determined at 0, 7, and 14 days post challenge (dpc) with MOCK (gray), or the PRRSV strains 144 (NADC30, dark blue), NC174 (red), VR2332 (green), or 142 (NADC20, light blue). The line graphs in panel illustrate the means with standard deviation of rectal temperatures [C]. Viremia and viral shedding were quantified by PRRSV-specific qPCR in serum and nasal swabs, respectively (genomic copy numbers/mL [log10]). The black bars represent the median values; in addition, individual data points are shown for MOCK vaccinated animals (open diamonds) and MLV vaccinated animals (filled squares). The data were analyzed using idk multiple comparison test 2-way ANOVA. Each vaccinated group was compared to their respective PRRSV type-2 challenge MOCK vaccinated group within each timepoint. < 0.0001, < 0.001, < 0.01, * < 0.05.
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yes
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PMC8803395
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Figure_4
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oa_package/4c/9c/PMC8803395.tar.gz
|
['FFPE tissue blocks were identified from each case corresponding to the six regions of the prostate targeted by urologists when performing standard sextant and 12-core (2 cores per sextant region) biopsy procedures (A).', 'For 2D analysis, average values from a total of 3 levels were calculated, in which the three levels were separated by 20 m (mimicking clinical practice at many institutions) as shown in A.', '.', '.', 'We compared multiple 3D and 2D glandular histomorphometric features (see Supplementary Table S3 for a detailed list).', "This can be quantified in the form of the average surface curvature of the object in 3D, or the curvature of the object's cross-sectional circumference in 2D (B).", 'As another example (C), the gland-to-convex-hull ratio (G/H) is defined as the volume ratio (in 3D) or the area ratio (in 2D) of the gland mask (epithelium + lumen) divided by the convex hull that circumscribes the gland.', 'For various 3D and 2D features (D and E; Supplementary Table S3), ROC curves were generated to quantify the ability of the features to stratify patients based on 5-year BCR outcomes.', 'This is exemplified by the significant P values for the 3D features showcased in B and C (between BCR and non-BCR groups) and higher area-under-the-ROC-curve (AUC) values (', '4D and E).', 'In F, we show two examples of skeleton-derived features: the average branch length and the variance of the branch lengths.', 'Both features are correlated with BCR outcomes based on P values and AUC values (F and G).', '05 (average SD; H), which is considerably higher than the AUC value (0.', 'Multiparameter classification models based on 3D features alone (nonskeleton) or 2D features alone were used to divide patients into high- and low-risk groups based on 5-year BCR outcomes (Supplementary Table S1), from which KM curves of BCR-free survival were constructed for a subset of cases in which time-to-recurrence (BCR) data are available (I).', 'The metrics presented in this study () are intended to be comparative in nature (between computational 3D vs.', 'Our results show clear improvements in risk stratification based on 3D glandular features, both individually and in combination (B I).']
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Figure 4. Clinical study comparing the performance of 3D versus 2D glandular features for risk stratification. Archived (FFPE) RP specimens were obtained from a well-curated cohort of 50 patients, from which, 300 simulated ( ) needle biopsies were extracted (6 biopsies per case, per sextant-biopsy protocol). The biopsies were labeled with a fluorescent analogue of H&E staining, optically cleared to render the tissues transparent to light, and then comprehensively imaged in 3D with OTLS microscopy. Prostate glands were computationally segmented from the resultant 3D biopsy images using the ITAS3D pipeline. Three-dimensional glandular features were extracted from tissue volumes containing prostate cancer. Two-dimensional glandular features were extracted from three levels per volume and averaged. and Violin and box plots are shown for two examples of 3D glandular features, along with analogous 2D features, for cases in which BCR was observed within 5 years of RP (BCR) and for cases with no BCR within 5 years of RP (non-BCR). For both sets of example features, lumen boundary curvature in and gland-to-convex hull ratio (G/H) in , the 3D version of the feature shows improved stratification between BCR and non-BCR groups. and ROC curves also show improved risk stratification with the 3D features versus corresponding 2D features, with considerably higher AUC values. Violin and box plots are shown of representative gland-skeleton features (average branch length and branch length variance), which can only be accurately derived from the 3D pathology datasets, showing significant stratification between BCR and non-BCR groups. ROC curves are shown, along with AUC values, for average branch length and branch length variance. ROC curves are shown of various multiparameter models, including those trained with 2D glandular features, 3D glandular features excluding skeleton features, and 3D glandular features including skeleton features. KM curves are shown for BCR-free survival, showing that a multiparameter model based on 3D glandular features is better able to stratify patients into low-risk and high-risk groups with significantly different recurrence trajectories ( = 6.6 10 , HR = 11.2, C-index = 0.84).
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yes
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PMC8403399
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Figure_11
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oa_package/d1/e4/PMC8403399.tar.gz
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[]
|
Fig. 11 IHC staining of the pons in ethanol fixed tissue sections from an MSA patient with antibodies to Syn carboxytruncated at residue 125. Immuno-staining with antibodies 2B1 and 5C1 specific for Syn carboxytruncated at residue 125 in the pons region of an MSA patient showing reactivity for both GCIs (arrow) and neuronal neuritic pathology (arrowheads). Tissue sections were stained with the Syn antibodies indicated in the top left corner. All sections were counterstained with hematoxylin. Scale bar=100m
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yes
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PMC3794976
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Figure_4
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oa_package/f6/65/PMC3794976.tar.gz
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['By 7 days post infection, both isolates caused leukocytic influxes into the spleen and liver () and formed granuloma-like lesions consistent with previous descriptions <xref rid="pntd.', 'g004Histopathological changes in liver and spleen following infection with S.']
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10.1371/journal.pntd.0002487.g004
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yes
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PMC8395905
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Figure_4
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oa_package/f8/08/PMC8395905.tar.gz
|
['However, the RA-induced increase in ABCG1 protein levels was decreased by all inhibitors: the p38, JNK and ERK inhibitors (A).', 'As shown in B D, RA significantly increased the phosphorylation of ERK1/2 (B), p38 (C) and JNK (D) beginning at 30 min until 8 h.', 'Similar to these reports, RA activated the ERK1/2, p38, JNK and PKC pathways (B D and B).', 'RA differentially regulates ABCA1 and ABCG1 protein expression through the MAPK signaling pathway.']
|
Figure 4 RA differentially regulates ABCA1 and ABCG1 protein expression through the MAPK signaling pathway. ( ) THP-1 macrophages were pretreated with the MAPK inhibitors PD98059 (an ERK inhibitor, 50 M), SB203580 (a p38 inhibitor, 40 M) and SP600125 (a JNK inhibitor, 5 M) ( ) for 1 h. Then, the cells were treated with RA (100 M) for 24 h, and ABCA1 and ABCG1 protein expression levels were analyzed by western blot analysis. ( ) THP-1 macrophages were treated with RA (100 M) for various durations (0.5, 1, 2, 4 and 8 h), after which phospho-ERK1/2 ( ), phospho-p38 ( ) and phosphor-JNK ( ) protein levels were determined by western blotting. Band densities were quantified and normalized for the loading controls -actin or total ERK1/2, total p38 and total JNK. Relative protein levels are presented as the mean SD ( = 5). * < 0.05, ** < 0.01 compared to the control; < 0.05, < 0.01 compared to the RA-treated group.
|
yes
|
PMC6213817
|
Figure_1
|
oa_package/f4/5b/PMC6213817.tar.gz
|
['Detailed GI pathology assessments are summarized in and .', 'The vast majority of NHPs experienced mesenteric lymphoid depletion and necrosis 27/31 (87%), but the extent of pathological findings varied by the segment of GI tract ( and ).', '16167829260687Summary of histopathologic findings for mesenteric lymph nodes, pancreas, and stomach in Ebola challenged rhesus macaques (n = 31).']
|
Figure 1 Summary of histopathologic findings for mesenteric lymph nodes, pancreas, and stomach in Ebola challenged rhesus macaques ( = 31).
|
yes
|
PMC6691153
|
Figure_5
|
oa_package/62/83/PMC6691153.tar.gz
|
['5) on the overall lifespan (A and Supplementary S4), the pharyngeal pump rate (C) and the number of body bends per second (D).', '0002) genes significantly reduced the viable number of progenies compared to the L4440 control group (B).', '005) groups compared to the L4440 control group (E).', '0002) genes also significantly increased osmotic tolerance compared to the L4440 control group (F).', 'Defects in stress resistance are ameliorated by silencing of fat-5 and fat-7 genes in C.']
|
Figure 5 Defects in stress resistance are ameliorated by silencing of and genes in expressing human mutated -synuclein (A53T mutation). Graphical representation of mean lifespan ( = 44 animals per group) ) viable progeny pharyngeal pump rate body bends heat tolerance and osmotic tolerance of JVR203 animals ( = 1015 animals per group) fed on different genetic RNAi treatments ( ). Empty vector L4440 was considered as control. The data represent the mean SEM with significant differences between the control and treatments at *** < 0.001. Each experiment was repeated three times.
|
yes
|
PMC3089598
|
Figure_1
|
oa_package/15/ac/PMC3089598.tar.gz
|
['This high throughput\nscreening assay identified a number of luciferase-inducing compounds that also\nhave the ability to increase the transcription of the endogenous mouse\nUTRN, thus identifying compounds with both human and mouse\nactivity eventually leading to the final optimized compound, SMT C1100 whose\nchemical structure is shown in \n1A.', 'g001\nIn vitro activity of SMT C1100.', '4 M (A).', 'In vitro dosing of human myoblasts with\nSMT C1100 leads to a 25 increase in utrophin mRNA (B) when compared to vehicle-only dosing\nafter three days of treatment.', '3 M after 3 days of treatment (C).', 'From the EC50 data (A), taken together with the levels of\nutrophin upregulation achieved at various drug concentrations in both DMD and\nnormal myoblasts, we can estimate that the effective concentration required for\nefficacy would be in the order of 0.']
|
10.1371/journal.pone.0019189.g001
|
yes
|
PMC10947957
|
Figure_4
|
oa_package/b6/0e/PMC10947957.tar.gz
|
[]
|
FIGURE 4 Quantification of IHC staining by all five antibodies on ERc and BA9. (A) IHC quantification in ERc for pT175, pT181, pT217, pT231, and AT8. (B) IHC quantification in ERc for pT175, pT181, pT217, pT231, and AT8. BrownForsythe for ANOVA followed by Dunnett's T3 multiplecomparisons test: < 0.05, < 0.01, < 0.001, < 0.0001. (C) Correlation matrix of IHC semiquantification with Braak stages, age, and PMI. The number represents Spearman , < 0.05, < 0.01, < 0.001, < 0.0001. ERc, entorhinal cortex; IHC, immunohistochemistry; PMI, interval.
|
yes
|
PMC10675542
|
Figure_8
|
oa_package/d6/29/PMC10675542.tar.gz
|
['Training Process with Overlay AugmentationOur tissue detection solution utilizes a convolutional neural network model with a standard U-Net architecture [29], which is configured as follows (): it comprises an input layer, succeeded by 6 encoder blocks.', 'The U-Net architecture consists of a contracting path of 7 layers that captures contextual information and a symmetric expansive path of another 7 layers that recovers spatial details.']
|
Figure 8 The U-Net architecture consists of a contracting path of 7 layers that captures contextual information and a symmetric expansive path of another 7 layers that recovers spatial details. The layers are interconnected with 2D max-pooling in the contracting branch, and we applied 2D convolutional transpose with batch normalization between the layers on the expanding branch.
|
yes
|
PMC9298068
|
Figure_1
|
oa_package/93/43/PMC9298068.tar.gz
|
[]
|
FIGURE 1 Dental health and periodontal disease. The tooth is composed of enamel, dentine, cementum, and the pulp. In healthy individuals, the alveolar bone ends approximately 1mm beyond the cementoenamel junction (marked by an asterisk). Periodontitis is characterized by progressive destruction of the toothsupporting tissues (alveolar bone, periodontal ligament, root cementum, and gingival attachment)
|
yes
|
PMC7487709
|
Figure_6
|
oa_package/8e/28/PMC7487709.tar.gz
|
[' 6).', ' 6).', '', 'NMJs were quantified from at least 8 animals (N = 8) taken from at least 3 independent crosses per genotypePreviously we demonstrated a length dependent decrease in spike amplitude in differentiated SH-SY5Y cells transfected with increasing repeat lengths of PolyAP [2].', ' 6d).']
|
Fig.6 Morphological analysis of the larval neuromuscular junction. Micrographs showing the neuromuscular junction (NMJ) (muscle 6/7 hemi-segment A3) of third instar larvae pan-neuronally expressing (nSyb-Gal4) DPRs. Anti-HRP labels the nervous system (magenta) and anti-bruchpilot (Brp/nc82) active zones (green). Scale bars 10m. Quantification of NMJ length, muscle surface area, bouton number and active zone number. ANOVA with post hoc Dunnetts multiple comparison to wild type controls ***p<.001; **p<.01; *p<.05. The number of NMJs analysed are shown on each graph. NMJs were quantified from at least 8 animals (N=8) taken from at least 3 independent crosses per genotype
|
yes
|
PMC3383704
|
Figure_4
|
oa_package/d7/43/PMC3383704.tar.gz
|
['g003"/>ZEB2 Downregulation Promotes Expression of E-cadherin but Suppresses EMT Progression in Glioma CellsExamination of the protein levels indicated that E-cadherin was significantly upregulated after siZEB2 transfection in both lines ().', 'Similarly, the expression of EMT-related regulators, such as N-Cadherin, Vimentin, -Catenin and Snail were decreased after ZEB2 knockdown ().', 'g004ZEB2 downregulation promotes expression of E-cadherin but suppresses EMT progression in glioma cells.']
|
10.1371/journal.pone.0038842.g004
|
yes
|
PMC11638628
|
Figure_4
|
oa_package/a1/0b/PMC11638628.tar.gz
|
['']
|
Fig. 4 Hepatic metastasis.
|
yes
|
PMC4015531
|
Figure_2
|
oa_package/ce/9c/PMC4015531.tar.gz
|
['Coronal MIP-images of a 44-year-old woman without any pathologies.']
|
Figure 2 Conventional MRA. Steady-state 3D VIBE sequence
|
yes
|
PMC8219441
|
Figure_2
|
oa_package/ce/b7/PMC8219441.tar.gz
|
['An impacted fracture of the anterior calcaneal process was also seen with a comminuted cuboid fracture and a third metatarsal fracture ().', 'In addition, the calcaneocuboid and subtalar joints were subluxed (s 2(a) and 2(c)).', '001"/>(a) 3D CT scan demonstrating swivel injury, comminuted fracture of the navicular and cuboid bone, and calcaneocuboid joint subluxation.']
|
Figure 2 (a) 3D CT scan demonstrating swivel injury, comminuted fracture of the navicular and cuboid bone, and calcaneocuboid joint subluxation. (b) 3D CT scan from medial viewpoint showing the medial dislocation of the talonavicular joint. (c) Sagittal CT cut of the left foot showing both talonavicular and subtle calcaneocuboid joint subluxations. (d) Axial cut of the CT scan showing medial dislocation of the talonavicular joint left foot; note the navicular fracture fragment that remained in the anatomic position; this constant fragment received screw fixation to aid in reconstruction of the navicular bone.
|
yes
|
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