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The extinction of morphine-induced conditioned place preference by histone deacetylase inhibition
|
Recent evidence suggests that epigenetic mechanisms have an important role in the development of addictive behavior. However, little is known about the role of epigenetic mechanisms in the extinction of morphine-induced behavioral changes. In this study, we will examine the effect of histone deacetylase (HDAC) inhibitors on extinction of morphine-induced conditioned place preference (CPP). To facilitate extinction, rats will be administered an HDAC inhibitor (HDACi) following nonreinforced exposure to the conditioned context. To measure persistence, rats were subject to a reinstatement test using 3 mg/kg dose of morphine. To exclude the effect of repeated NaBut injections themselves on morphine-CPP in the absence of extinction session, rats received injection of either NaBut or vehicle for 8 days. We found that HDAC inhibition during nonconfined extinction or confined extinction consolidation can facilitate extinction of morphine-induced CPP. We also showed that the extinction of drug seeking via HDAC inhibition modulates extinction learning such that reinstatement behavior is significantly attenuated. There is no effect of repeated NaBut injections themselves on morphine-CPP in the absence of extinction session. In conclusion, our results extend earlier reports on the ability of HDACi to modify the behavioral effects of drugs of abuse. Our increasing understanding of these epigenetic mechanisms will provide key answers to basic processes in drug addiction and hopefully provide insight into designing improved treatments for drug addiction.
|
publication
|
[
[
"Health",
"Civil Security for Society"
]
] |
[
[
"Non-communicable and rare diseases",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
W2005513120
|
Energiesuffizienz erforschen: Neue Herausforderungen und Chancen in Krisenzeiten
|
Der Krieg in der Ukraine verändert die politischen Prämissen in rasender Geschwindigkeit. Wie sollen Politik und Gesellschaft auf hohe Energiekosten und eine fatale Abhängigkeit von fossilen Energieimporten reagieren? Können moderne Gesellschaften mit viel weniger Energie auskommen? Energiesuffizienz kann eine wichtige Rolle bei der Beantwortung dieser Fragen spielen. Die Beiträge in diesem Special topic erforschen Suffizienz als einen interdisziplinären Forschungsgegenstand für Energiemodellierung, -szenarien und -politik.
|
publication
|
[
[
"Climate, Energy and Mobility"
]
] |
[
[
"Buildings and industrial facilities in energy transition",
"Energy supply",
"Energy systems and grids"
]
] |
W4285726788
|
Adattare l'attività di Ecoplay al contesto della COVID-19
|
Questo progetto di investimento mira ad adeguare l'attività commerciale della società promotrice alle nuove condizioni imposte dalla malattia di COVID-19 al fine di garantire il rispetto delle norme stabilite e delle raccomandazioni imposte.
|
project/regional
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Circular systems"
]
] |
Q2911819
|
Open Network for Mediterranean Sustainable Tourism 2
|
Project in brief _x000D_
_x000D_
Tourism is an important sector of the economy in the Mediterranean region and in some cases it significantly contributes to local development representing the main source of income for local populations. However, the Mediterranean model is still based on mass tourism with a concentration in time and in a limited number of destinations mostly related to coastal areas. In order to contribute to the diversification of tourism offer, ONMEST 2 project aims to enhance minor destinations such as Ipsica (Italy), Kalavrita (Greece), Alcaraz (Spain), Kadisha Valley (Lebanon), Birzeit (Palestine), Umm Qais (Jordan) and Béja (Tunisia), and turn them into ‘Centers of Local Culture’ as privileged places of sustainable tourism. _x000D_
_x000D_
Specific objective _x000D_
_x000D_
To enhance the minor tourist destinations in marginal geographical areas in Italy, Greece, Spain, Lebanon, Palestine, Jordan and Tunisia and turn them into ‘Centers of Local Culture’ as privileged places of sustainable tourism
|
project/regional
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Social and economic transformations",
"Culture, cultural heritage and creativity"
]
] |
interreg_2574
|
Protein Interactions and Localization of the Escherichia coli Accessory Protein HypA during Nickel Insertion to [NiFe] Hydrogenase
|
Nickel delivery during maturation of Escherichia coli [NiFe] hydrogenase 3 includes the accessory proteins HypA, HypB, and SlyD. Although the isolated proteins have been characterized, little is known about how they interact with each other and the hydrogenase 3 large subunit, HycE. In this study the complexes of HypA and HycE were investigated after modification with the Strep-tag II. Multiprotein complexes containing HypA, HypB, SlyD, and HycE were observed, consistent with the assembly of a single nickel insertion cluster. An interaction between HypA and HycE did not require the other nickel insertion proteins, but HypB was not found with the large subunit in the absence of HypA. The HypA-HycE complex was not detected in the absence of the HypC or HypD proteins, involved in the preceding iron insertion step, and this interaction is enhanced by nickel brought into the cell by the NikABCDE membrane transporter. Furthermore, without the hydrogenase 1, 2, and 3 large subunits, complexes between HypA, HypB, and SlyD were observed. These results support the hypothesis that HypA acts as a scaffold for assembly of the nickel insertion proteins with the hydrogenase precursor protein after delivery of the iron center. At different stages of the hydrogenase maturation process, HypA was observed at or near the cell membrane by using fluorescence confocal microscopy, as was HycE, suggesting membrane localization of the nickel insertion event.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Advanced Materials"
]
] |
W1969557555
|
(14508.17092020.172000911) INVCALUGI
|
¿HA PLANEADO LA EMPRESA UN AUMENTO DE LA PRODUCTIVIDAD? 12 MESES. SOBRE LA BASE DE LOS ANÁLISIS REALIZADOS PARA LOGRAR ESTA MEJORA PRODUCTIVA Y EFICIENCIA, LA COMPAÑÍA HA DECIDIDO ADQUIRIR MÁQUINAS QUE PERMITAN UN IMPORTANTE DESARROLLO FUTURO EN EL REINO UNIDO PARA UNA MAYOR COMPETITIVIDAD. ¿LA CALIDAD? SE REFORZARÁN AÚN MÁS LOS PRODUCTOS Y LAS NORMAS DE SEGURIDAD. ¿VENDRÁ? INSTALÓ UNA OLLA AL VACÍO PRODUCIDA EN ITALIA POR ROBOQBO. ¿ES SAR? ¿CONECTADO A UNA NUEVA PLANTA EN LÍNEA QUE LO PERMITIRÁ? TRABAJO CONTINUO DE AL MENOS 3 ETAPAS DE PROCESAMIENTO: SOPLAR Y LIMPIAR VIDRIOS, LLENAR CONTENEDORES AUTOMÁTICOS Y TAPARLOS EN VACÍO. ¿SAR? ¿UNA OPERACIÓN MUY IMPORTANTE QUE PERMITIRÁ? ¿DOBLAR LA PRODUCCIÓN Y, POR LO TANTO, AUMENTAR LA COMPETITIVIDAD? EN LOS MERCADOS INTERNACIONALES QUE REQUIEREN ESTÁNDARES DE PRODUCCIÓN ELEVATI.IN EN PARTICULAR, ¿VENDRÁ? ADQUIRIDO:-ROBOQBO (CUUOCITORE)- PME (SOPLADOR Y MÁQUINA TAPONADORA)- KARR (MÁQUINA DE LLENADO)
|
project/regional
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
Q4936852
|
Lymph Node Yield and Oncologic Outcome after Colorectal Cancer Resection
|
When performing mesorectal and mesocolic excision for rectal and colon cancer, it is crucial to encompass the draining nodal basins for staging and, possibly, therapeutic purposes. During the past 15 years, colorectal cancer investigators have demonstrated a relationship between the number of lymph nodes examined in the surgical specimen and oncologic outcome. However, the nature of this relationship has not been clearly elucidated. Early explanations for this finding were based on the concept of understaging. The hypothesis was that with fewer nodes examined, the pathologist was less likely to identify metastatic nodes and the patient would be given an inappropriate diagnosis of stage I or II rather than stage III cancer. However, the linear relationship between the total number of lymph nodes in the specimen and the number of metastatic lymph nodes argues against understaging as the primary explanation. If understaging was the cause of this phenomenon, the number of positive nodes would plateau at a certain number of total lymph nodes examined. Yet, multiple investigators have been unable to demonstrate that there is a number above which examination of additional lymph nodes does not identify more metastatic nodes. Many authors have hypothesized that maximal surgical clearance of metastatic lymph nodes offers therapeutic effect. Although this may be intuitive, mesenteric lymph node recurrence is a very uncommon phenomenon, and this hypothesis remains unsupported. Kanemitsu et al. have attempted to use their results to support the practice of central vascular pedicle ligation. However, they state that it is standard practice in Japan to resect apical nodes if the stage is T2 or higher; in this study there is no control group without proximal ligation. As a result, such an assumption cannot be supported by these data nor is there conclusive evidence elsewhere in the existing colorectal cancer literature that proximal pedicle ligation improves oncologic outcome or is necessary for adequate lymph node yields. In a study, conducted by this author, of a consecutive series of surgical specimens at a single center, apical vessel ligation was not universally performed; yet 96 % of the specimens were found to contain more than 12 lymph nodes. Meticulous surgical technique and careful pathologic examination is paramount to achieve high lymph node yields. Many protocols have been advocated to maximize nodal yield, including the use of in vivo or ex vivo dye injection, fat clearance, and multiple rounds of gross examination. However, one cannot categorically state that specific surgical or pathologic methods are necessary to achieve such yields in all cases, because this has not been adequately studied in a prospective, controlled fashion. Kanemitsu et al. have elegantly demonstrated that, in a broad population of stage II colorectal cancer patients, the threshold of 12 lymph nodes examined is associated with superior predictive capacity for prognosis in individual patients. Moreover, they acknowledge that this association is not straightforward. However, their discussion focuses on improved staging and clearing of micrometastatic disease, neither of which has been proven causal despite almost two decades of investigation. Biologic explanations need to be examined further. Age, tumor size, depth of penetration, location, use of radiation, and gene mutations have been associated with lymph node yield. These findings suggest a host–tumor interaction that may result in stimulation of the immune system and, as a consequence, larger and thus easier to identify mesenteric lymph nodes. It does not stretch the imagination to consider that such an interaction would have implications for tumor recurrence. Our understanding of the biology of lymph node hypertrophy or proliferation in the presence of a colorectal Society of Surgical Oncology 2012
|
publication
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems"
]
] |
W1973350519
|
Neuron-Based monitoring electrochemical bio-sensor interface system
|
Reliable, real-time detection systems for in-vivo, continuous monitoring of biological and chemical processes consist a crucial aspect in personalised healthcare. Nevertheless, even nowadays, the medical practice still lacks of systems providing a rapid, reliable and ultra-sensitive sensing in a continuous way. Meanwhile, inflammatory markers consist a pivotal tool in clinical practice since they may be indicators of specific diseases, along with signalising the response of a patient to a specific medical treatment. Nanotechnology-based devices exhibiting memristive electrical properties show great potential for delivering highly scalable, resilient, power efficient and reconfigurable electronic systems. In addition, when those particular nanodevices are subjected to appropriate surface treatments and implemented in the role of bio-inspired sensors, they can bring solutions and introduce novelty to the bio-sensing field regarding highly sensitive and robust detection of biomarkers, while expanding and broadening the research field and applications involving memristive phenomena. In the framework of this fellowship, a flexible, low-cost miniaturised minimally invasive sensing platform will be developed, implementing memristive nanoscale devices as intelligent bio-interfaces, allowing reliable, continuous and real-time monitoring of inflammatory markers. This scheme will be accomplished by the fabrication of a memristor-based sensing platform conjugated with a sensing membrane and an accordingly designed binding assay. Validation of the sensing platform for continuous monitoring will be followed by the integration on flexible substrates for in vivo measurements and integration with readout circuitry enabling the sensing data readout and the wireless transmission to a tablet or smartphone. Finally, the sensing platform will be applied for in-vivo, real-time monitoring, for the detection of inflammatory markers and for indicating the response to an applied treatment.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
225276
|
Molecular dynamic simulation of high-quality hydrogen storage in pillared bilayer graphene bubble structure
|
Abstract The storage of molecular hydrogen in a novel 3D carbon structure – pillared graphene bubble system under various environments is calculated using molecular dynamics (MD) method. The graphene-based structures are designed with different sizes of semi-ellipsoidal graphene bubbles. The effects of pressure, temperature, and graphene interlayer spacing are systematically investigated in the isothermal–isobaric (NPT) ensemble. Meanwhile, the internal pressures of molecular hydrogen in bubbles under various environments are also estimated. Results show that the hydrogen storage capacity of the pillared graphene bubble structures can be maximized by decreasing the temperature and increasing the pressure and the graphene interlayer spacing. The MD simulations demonstrate that the maximum gravimetric and volumetric H 2 densities inside the developed system are 13.7 wt% and 121.6 kg/m 3 , respectively. Impressively, the maximum gravimetric and volumetric H 2 densities of the developed system are also calculated – 21.3 wt% and 210.3 kg/m 3 , respectively, when the outer surface adsorption are taken into consideration. These values satisfy the requirements for mobile applications set by the U.S. Department of Energy (DOE).
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Energy storage"
]
] |
W971826552
|
Another look at climate sensitivity
|
Abstract. We revisit a recent claim that the Earth's climate system is characterized by sensitive dependence to parameters; in particular, that the system exhibits an asymmetric, large-amplitude response to normally distributed feedback forcing. Such a response would imply irreducible uncertainty in climate change predictions and thus have notable implications for climate science and climate-related policy making. We show that equilibrium climate sensitivity in all generality does not support such an intrinsic indeterminacy; the latter appears only in essentially linear systems. The main flaw in the analysis that led to this claim is inappropriate linearization of an intrinsically nonlinear model; there is no room for physical interpretations or policy conclusions based on this mathematical error. Sensitive dependence nonetheless does exist in the climate system, as well as in climate models – albeit in a very different sense from the one claimed in the linear work under scrutiny – and we illustrate it using a classical energy balance model (EBM) with nonlinear feedbacks. EBMs exhibit two saddle-node bifurcations, more recently called "tipping points," which give rise to three distinct steady-state climates, two of which are stable. Such bistable behavior is, furthermore, supported by results from more realistic, nonequilibrium climate models. In a truly nonlinear setting, indeterminacy in the size of the response is observed only in the vicinity of tipping points. We show, in fact, that small disturbances cannot result in a large-amplitude response, unless the system is at or near such a point. We discuss briefly how the distance to the bifurcation may be related to the strength of Earth's ice-albedo feedback.
|
publication
|
[
[
"Climate, Energy and Mobility"
]
] |
[
[
"Climate science and solutions",
"Energy systems and grids"
]
] |
W3099754316
|
Is there delay in diagnosis of pulmonary tuberculosis in an intermediate-to-low TB incidence setting.
|
A cross-sectional study on pulmonary TB diagnosis delay in an intermediate TB incidence setting showed average patient's delay of 44 +/- 61.65 days and total delay of 103 +/- 148 days. Alcoholism, lack of TB cases in family, diabetes mellitus, relapse, cough or tachycardia (p< 0.01), absence of hemoptysis, dyspnea and anemia (p < 0.01), age > or = 40 (p < 0.05), negative auscultation and positive sputum smear findings (p < 0.05) were significantly associated with patient's delay > 30 days. Age < 40 years, negative auscultation and sputum smear findings (p < 0.01), female sex, city as residence (p < 0.05), absence of cough, sputum, weight loss, fever, excavation (p < 0.01), and night sweats (p < 0.05) were significantly associated with total delay > 103 days. Further population education and continual medical education are waranted.
|
publication
|
[
[
"Health"
]
] |
[
[
"Healthcare systems",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W84065516
|
Super high efficiency cu(in,ga)se2 thin-film solar cells approaching 25%
|
Prime objective of the Sharc25 project is to develop super-high efficiency Cu(In,Ga)Se2 (CIGS) solar cells for next generation of cost-beneficial solar module technology with the world leading expertise establishing the new benchmarks of global excellence.
The project partners ZSW and EMPA hold the current CIGS solar cell efficiency world records of 21.7% on glass and 20.4% on polymer film, achieved by using high (~650°C) and low (~450°C) temperature CIGS deposition, respectively. Both have developed new processing concepts which open new prospects for further breakthroughs leading to paradigm shift for increased performance of solar cells approaching to the practically achievable theoretical limits. In this way the costs for industrial solar module production < 0.35€/Wp and installed systems < 0.60€/Wp can be achieved, along with a reduced Capex < 0.75€/Wp for factories of >100 MW production capacity, with further scopes for cost reductions through production ramp-up.
In this project the performance of single junction CIGS solar cells will be pushed from ~21% towards 25% by a consortium with multidisciplinary expertise. The key limiting factors in state-of-the-art CIGS solar cells are the non-radiative recombination and light absorption losses. Novel concepts will overcome major recombination losses: combinations of increased carrier life time in CIGS with emitter point contacts, engineered grain boundaries for active carrier collection, shift of absorber energy bandgap, and bandgap grading for increased tolerance of potential fluctuations. Innovative approaches will be applied for light management to increase the optical path length in the CIGS absorber and combine novel emitter, front contact, and anti-reflection concepts for higher photon injection into the absorber. Concepts of enhanced cell efficiency will be applied for achieving sub-module efficiencies of >20% and industrial implementation strategies will be proposed for the benefit of European industries.
|
project/european
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Energy storage",
"Energy supply",
"Energy systems and grids"
]
] |
171817
|
Use case for european robotics in ophthalmologic micro−surgery
|
EurEyeCase combines cutting−edge European robotic technology and creates an integrated setup for the very challenging use case of vitreoretinal eye surgery. Nowadays, a selected number of highly−skilled ophthalmologists are treating large numbers of patients that suffer from various types of vitreoretinal eye diseases. The majority of these intra−ocular interventions lie on or even beyond the boundaries of human skills as they pose extreme requirements in terms of manipulation and positioning precision. As a result, current treatments are characterized by moderate success rates and even an inability to adequately treat some common diseases. As a consequence, a large group of patients is left untreated or receives suboptimal treatment only. Robotic technology can and is likely to put an end to the current status−quo. Starting from existing hardware, knowledge and IP and in close collaboration with medical partners, EurEyeCase will build up and validate a convincing robot−assisted operation suite, which will help surgeons in treating a selection of particular demanding vitreoretinal procedures including the treatment of retinal vein/artery occlusion through cannulation and epiretinal membrane treatment. Current laboratory setups will be studied in detail, augmented and tailored for successful integration into the surgical workflow. Novel sensing technologies will be further developed and integrated with advanced control methods to deliver unprecedented levels of safety and performance. In-depth evaluation of the setup in different directions, i.e, performance, usability and clinical relevance, as well as the first steps to transfer the most challenging developments to the next phase of product development are key aspects of the project. EurEyeCase will demonstrate how medical robotics technology can boost success rates of urgent and critical surgical interventions and paves the way for novel promising treatment methods with demonstrated improvements in patient outcome.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
169841
|
Regulation and reprogramming of alternative splicing in cellular transformation
|
Alternative splicing (AS), by affecting nearly 90 percent of human genes, is the major contributor to protein diversity. Mutations that disrupt AS regulatory sequences are a widespread source of human diseases. Various evidences suggest that an AS reprogramming is critical in cell adaptation during cancer development. In spite of increasing interest in the potential oncogenic role of AS, little is known about the molecular mechanisms behind its deregulation during the somatic to the cancer cell transformation.
Our aim is to contribute to the characterisation of AS reprogramming during the somatic to the proliferative cancer cell transformation using myosin VI as model system. Recent studies from the host lab reported how myosin VI AS modulates its interactome leading to different cellular functions (endocytosis for the long isoform and cell migration for the short one). The lab found that alternative myosin VI splicing is aberrantly regulated in cancer, where exon skipping dictates cell addiction to myosin VIshort for tumour cell migration.In this proposal, we intends to 1) Identify the myosin VI’s alternative splicing regulators and define their role in vitro, 2) identify common splicing-regulated events that occur during the establishment of a fully polarized epithelial architecture and that are possibly deregulated in cancer (AS reprogramming), 3) assess whether cancer stem cells express a specific set of the identified AS genes.Preliminary results revealed that myosin VI isoforms expression can be switch on/off in selective culture conditions. We will take advantage of this beahviour to set up our analysis based on a multidisciplinary approach that includes biochemical, mass spectrometry and cellular biological assayes. The new set of information will gained with this proposal will be instrumental to understanding the molecular mechanism at the basis of AS (de)regulation for myosin VI and more in general for cell transformation during cancer progression.
|
project/european
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
219948
|
Revealing the transient structures of intrinsically disordered proteins by microfluidics-enabled hydrogen-deuterium exchange
|
This Fellowship proposal will design, fabricate and test novel microfluidic chips for the study of intrinsically disordered proteins (IDPs) by Hydrogen-Deuterium Exchange coupled with Mass Spectrometry (HDX-MS). The research program will use thiol-ene polymerisation to form all components of the microchip allowing fast, reproducible and cheap fabrication. The microchips will incorporate multiple microfluidics channels of varying length and spatially restricted monolith plugs to allow sub-second HDX reactions to occur on-chip. The microchips will circumvent the extensive and error-prone sample pre-treatment steps of current commercial HDX-MS methodology. I will be trained in state-of-the-art HDX-MS technology and will learn how to perform site-specific, light-activated thiol-ene click-chemistry reactions. The microfluidic chips will be used to probe the transient conformational changes of three challenging IDPs of biological and pharmaceutical relevance: a-synuclein, proNerve Growth Factor (proNGF) and Epsin1. α-synuclein is an extensively characterised model IDP, shown by numerous biophysical techniques including HDX-MS to possess some regions of transient structure. α-synuclein will be used during microchip development, providing valuable proof-of-concept and a framework for which to further optimize microchip design if needed. I will then characterise the conformational states and interactions of proNGF; the cleavable pro-element is reported to be disordered, but there is little knowledge of its cellular roles. Previously unreported structural elements of Epsin1, an IDP shown to mediate lipid membrane curvature, will also be probed. HDX-MS will be complemented by electron transfer dissociation (ETD) and ion mobility separation (IM-MS).To be added
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project/european
|
[
[
"Health"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
225255
|
Preventing recurrence of spontaneous pneumothorax after thoracoscopic surgery: A review of recent results
|
Spontaneous pneumothorax (SP) is now commonly treated with thoracoscopic surgery, which is associated with less pain and a shorter hospital stay than thoracotomy; however, in its initial stages, thoracoscopic stapled bullectomy resulted in an unexpectedly high incidence of postoperative SP recurrence. Thus, new thoracoscopic procedures, designed to be performed in addition to stapled bullectomy, were developed, which resulted in a gradual decline in the postoperative recurrence rate. We review the recent literature on SP recurrence after thoracoscopic surgery with these other surgical procedures. Pleurectomy and pleural abrasion have been performed for a long time with low recurrence rates; however, they cause the lung to adhere to the parietal pleura, often resulting in complications such as postoperative bleeding. Other surgical procedures that may be recommended to minimize the risk of recurrence are reinforcement of the staple lines using fleece-coated glue or an absorbable sheet. These procedures are now considered to be the thoracoscopic treatment of choice for SP.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
W1985867760
|
Integrating Carbon Footprint into Coordination of Constant Pricing and Lot Sizing Problem
|
The purpose of this paper is to improve our understanding of how carbon emission concerns could be integrated into operational decision-making with regard to procurement, production, and inventory management. Lot sizing model with constant product pricing can be modified to support decision-making that accounts for both profit and carbon footprint, by combining carbon footprint parameters with various decision variables. In the first case, the strict carbon cap is introduced into coordination of product pricing and lot sizing. The second case with carbon trade can be achieved by the Lagrangian relaxation of the carbon cap in the first case. In particular, the model with carbon trade is transformed into the third model with carbon tax when the carbon cap equals zero. The results show a series of insights that highlight the impact of operational decisions on carbon emissions and the importance of operational models in evaluation the impact of different regulatory policies and in assessing the benefits of investments in more carbon efficient technologies.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Climate science and solutions",
"Energy supply"
]
] |
W2064900942
|
Building automation and control systems: A case study to evaluate the energy and environmental performances of a lighting control system in offices
|
Abstract Building automation and control systems (BACs) allow plants in buildings to be controlled and managed, thus increasing the users' comfort and reducing the operation and maintenance costs. As far as the lighting services are concerned, control systems offer an important opportunity of managing lighting systems and reducing energy consumption, due to the use of integration strategies between daylight and electric lighting and strategies based on the occupancy of spaces. The results of an experimental case study of ten offices in Torino (Italy), in which a custom-design building automation and control system has been designed to control both the lighting plants and the air conditioning system, are presented in this paper. The study was carried out in order to evaluate the energy efficiency of the lighting control system and to analyse the environmental luminous conditions obtained through the application of this technology to a real case. The environmental and energy performances, together with the degree of users' satisfaction and acceptance of this control system, were analysed after a year of activity to verify the potentiality and operation of this lighting control system. The obtained results regarding the potential energy savings (from 17% to 32%) were evaluated taking into account both the monitored annual electric energy consumption (for operation) and the parasitic energy consumption due to the installed devices (luminaire ballasts, sensors and controllers), and were compared with the estimated energy consumption calculated applying the method proposed in the European standard EN 15193:2007.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Buildings and industrial facilities in energy transition",
"Energy systems and grids"
]
] |
W2022328916
|
Method of Tracking Health and Performance Statistics of Visitors to a Health Theme Park
|
A method of tracking health and performance statistics of visitors to a health theme park is utilized to monitor vital signs and activity performance (VSAP) statistics for visitors participating in a theme park activity. At least one database server manages a plurality of user profiles for visitors to the theme park. The VSAP statistics are measured during the theme park activity with a corresponding wearable health monitoring (WHM) device that is associated with the visitor. The visitor is ranked amongst other visitors based on at least one performance metric that is quantitatively assessed based on the VSAP statistics. A performance rank is generated based on the at least one performance metric. The corresponding WHM device is capable of a plurality of ancillary features that may be selected through the corresponding WHM device. A desired feature is executed with the at least one database server.
|
patent
|
[
[
"Health",
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
US 201615076923 A
|
Development of highly-efficient low-emission log wood-fired closed fireplace inserts thanks to an automated electronic control system
|
RIKA, as one of the European market leaders regarding log wood and pellet stoves, aims at a significant extension of its product portfolio by the development and market introduction of a new closed fireplace insert technology, the INSERTRONIC. With this technology which shall distinguish itself from competing products by significantly reduced emissions, increased efficiency as well as increased user comfort, RIKA will become a complete supplier for wood based room heaters. Thereby, RIKA aims at strengthening its position as European technology leader as well as to double its turnover until 2022. A technical concept of the INSERTRONIC, which builds on RIKA’s innovative log wood stove technology, has already been defined. Within the project the new technology shall be developed, tested and optimised in order to pass type testing at project end. A number of innovations (world-wide novelties for fireplace inserts) shall be implemented, of which the most important are (i) the utilisation of novel insulation materials as well as materials with catalytic coatings for emission reduction, (ii) the application of modern computational fluid dynamics (CFD) simulation tools for process design and optimisation, (iii) the implementation of an automated control and ignition system as well as (iv) the development of a flexible insertion frame and modular panelling system which provide a high flexibility regarding installation and outer appearance. Techno-economic analyses in order to keep the final product costs at a competitive level as well as dissemination, communication and commercialisation measures shall ensure a quick market introduction after project end.
Since the European closed fireplace insert market amounts to about 850,000 units/year, the new technology will have a
significant impact on a more efficient utilisation of biomass resources as well as a reduction of CO2 emissions (substitution
of fossil fuels) and therefore will be of great relevance to the Work Programme.
|
project/european
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Buildings and industrial facilities in energy transition",
"Energy supply"
]
] |
173059
|
Estudo da análise granulométrica por peneiramento de minérios da região de Carajás - PA
|
O conhecimento da distribuição de tamanhos de um conjunto heterogêneo de partículas, chamado análise granulométrica, é uma importante ferramenta nos estudos de caracterização tecnológica de minérios, no controle de qualidade de um produto para comercialização, na seleção de equipamentos ou em processos de beneficiamento de minérios. Vários métodos foram desenvolvidos para essa finalidade, quase sempre, baseados na similaridade geométrica ou hidrodinâmica das partículas. Na análise granulométrica por peneiramento, método mais antigo e bastante utilizado na prática laboratorial, alguns fatores podem influenciar o resultado, como o tempo de peneiramento e a massa de material a ser analisada; pode ser a seco, a úmido ou combinado, vai depender da característica do material a ser ensaiado. No entanto, em laboratório, ainda é comum utilizar erroneamente massa e tempo padrões para diferentes materiais, sem levar em consideração suas particularidades (principalmente densidade). O objetivo principal deste trabalho é determinar a massa e o tempo adequados, nos ensaios de análise granulométrica por peneiramento, para os minérios de ferro e cobre da região de Carajás-PA. Utilizando a equação proposta por Gaudin, que determina a massa máxima que deve ficar retida em cada peneira, e ensaios sucessivos de peneiramento com tempos crescentes até que a massa passante em uma ou mais peneiras não varie mais do que 0,1%, espera-se encontrar a massa e o tempo adequados para cada minério estudado, contribuindo assim com as práticas laboratoriais do tratamento de minérios.
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publication
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
W4281846447
|
STUB MINIMIZATION FOR MULTI-DIE WIREBOND ASSEMBLIES WITH PARALLEL WINDOWS
|
A microelectronic package 10 can include a substrate 20 having first and second surfaces 21, 22 and first and second apertures 26a, 26b extending therebetween, first and second microelectronic elements 30a, 30b each having a surface 31 facing the first surface, terminals 25a exposed at the second surface in a central region 23 thereof, and leads 40 electrically connected between contacts 35 exposed at the surface of each microelectronic element and the terminals. The apertures 26a, 26b can have first and second parallel axes 29a, 29b extending in directions of the lengths of the respective apertures. The central region 23 of the second surface 22 can be disposed between the first and second axes 29a, 29b. The terminals 25a can be configured to carry address information usable by circuitry within the microelectronic package 10 to determine an addressable memory location from among all the available addressable memory locations of a memory storage array of at least one of the microelectronic elements 30a, 30b.
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
US 2012/0057905 W
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Conclusão da fábrica de produção GK-Mont s.r.o. pela sala de produção-armazenamento (ID 4801 — Ex-Edifícios de Gestão Florestal Horní Planá)
|
O objetivo do projeto é construir novas instalações de produção numa empresa que se dedica à produção de produtos refratários, substituindo edifícios de construção tecnicamente não conformes, onde o projeto irá remover e construir uma nova sala de produção-armazenamento. A execução do projeto irá, em última análise, refletir positivamente tanto no reforço da posição concorrencial da empresa no mercado como contribuirá também para manter e aumentar ainda mais o emprego na empresa e melhorar o seu impacto na empresa ferroviária.
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project/regional
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
Q14187
|
METHOD FOR PRODUCING TEMPERATURE RESISTANT NONWOVENS
|
Temperature resistant multilayer composites, methods for making same, and articles made therefrom. The method can include extruding one or more polyolefm polymers having a MFR from less than 90 dg/min through at least one die having a plurality of nozzles to form a plurality of continuous fibers, at least one die operating at a melt pressure from greater than 500 psi (3447 kPa) to form at least one elastic meltblown layer; adhering the at least one elastic meltblown layer to at least one extensible layer to form a multilayer composite; and at least partially crosslinking the elastic meltblown layer or the extensible layer or both.
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
US 2011/0024582 W
|
MoveOSC — Smart Watches in Mobile Music Performance
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Smart watches with motion sensors offer the potential of bringing hand-gesture based music performance to a large audience by removing the need for custom hardware. It further removes artifacts from the hand, as would be present when a smart phone or a motion-controller such as the Wiimote are used. We discuss the potential and technical limitations of a current generation commodity smart watch (Pebble) and describe contribution to music software on mobile devices. By using Open Sound Control (OSC) as well as ZeroConf/Bonjour networking an accessible setup for musical control by smart watches is provided. Furthermore the integration into the mobile music environment urMus allows flexible use in a broad range of more sophisticated performances.
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publication
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[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics",
"Emerging enabling technologies",
"Key digital technologies",
"Advanced computing and big data",
"Next generation internet"
]
] |
W2188160794
|
Discovering new disease pathways affecting mtdna metabolism
|
Defects of mitochondrial DNA (mtDNA) metabolism (maintenance, integrity and expression) are the most common cause of multiple mitochondrial respiratory chain (MRC) defects in children. Several new disease genes have been identified in these complex pathways but the functional link between mutant protein and mtDNA metabolism is unknown or poorly understood. Example of the latter is FBXL4 (F-box and leucine-rich repeat protein 4) gene, mutations of which have been recently found in 28 patients with a multisystem complex syndrome, hallmarked by combined MRC defect and reduction of mtDNA copy number in muscle and fibroblasts. Approximately 60% of patients still lack genetic definition of their disease. Objective of MITOBIOPATH proposal is the discovery and characterization of novel mitochondrial biogenetic and maintenance pathways by implementing three specific aims. 1) Gene discovering by whole exome sequencing (WES): unbiased WES screening will be applied to a large cohort of paediatric patients presenting early onset hypotonia, developmental delay, failure to thrive, severe encephalomyopathy and/or liver failure associated with combined MRC defects. 2) Pathogenic pathways revealed by new gene defects: functional studies using cellular and animal models (knock-out zebrafish or mouse models) will be performed to establish the pathogenic mechanism of the mutation(s) and the function of unknown disease-associated protein(s); 3) FBXL4 function in cellular and in vivo models: immortalized cell lines expressing six different FBXL4 mutations will be generated by using CRISP/Cas9 technology and characterized with a combined molecular, biochemical and proteomic approaches. In addition, proteins in the Parkin-proteasome complex were recently identified as potential partners of FBXl4, and they will be further analyzed. Knock-out mouse model of Fbxl4 will be also investigated.
Overall results will have impact on both mitochondrial disorders and other neurodegenerative disease.
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project/european
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[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Health throughout the life course",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
184667
|
An Early Permian (ca. 280Ma) silicic igneous province in the Alxa Block, NW China: A magmatic flare-up triggered by a mantle-plume?
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Abstract Silicic igneous provinces have important implications for geodynamic processes. In this study, we show that the predominantly Early Permian (ca. 280 Ma) granitoids in the Alxa Block correspond to an important silicic igneous province with areal distribution in Northwest (NW) China. We present zircon U–Pb age and Hf–O isotopic, and whole-rock geochemical and Sr–Nd isotopic data for the newly identified I- and A-type granites and high Sr/Y granodiorites in the Bayannuoergong batholith, and gabbros, diorites and quartz diorites in the Bijiertai Complex, Alxa Block. The I-type monzogranites, granodiorites and A-type granites of the Bayannuoergong batholith were probably generated by mixing between crust- and mantle-derived magmas, partial melting of a thickened eclogitic lower crust and underplated mantle-derived mafic rocks, respectively. The gabbros, quartz diorites and diorites of the Bijiertai Complex were likely generated by partial melting of the lithospheric mantle, differentiation from basaltic magmas and partial melting of the middle crust, respectively. Despite pronounced geochemical and isotopic heterogeneity of these rocks, new SIMS and LA–ICP-MS U–Pb zircon dating indicates that they were formed over a very short time interval at ca. 280 Ma. Thus, the mantle, lower crust and middle crust underwent widespread melting at this time. Given that these magmatic rocks have no spatial or temporal zonation, and were probably formed in an extensional setting, we suggest that the ca. 280 Ma Tarim mantle plume in NW China may have triggered the magmatic flare-up of the Alxa silicic igneous province.
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publication
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies"
]
] |
W2028042452
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miDivCon: Framework and method for Multiple Instance Learning
|
We present a new framework and method for solving Multiple Instance Learning (MIL) problems. As a variation on supervised learning, MIL addresses the problem of classifying a bag of instances. If at least one of the instances in a bag is positive the bag is labeled positive, otherwise it is negative. We use a divide and conquer strategy to identify true positive group of instances in the positive bags and use Bayesian statistics to minimize the false positive instances in the same bags. After testing on benchmark data we also use the method on a challenging task of predicting behavior from molecular profiles data. Comparison results show that our method performs on par or better than other MIL methods.
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publication
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Emerging enabling technologies",
"Artificial intelligence and robotics"
]
] |
W1614190803
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Sustainable and Hydrolysis-Free Dyeing Process for Polylactic Acid Using Nonaqueous Medium
|
A sustainable and hydrolysis-free dyeing process was developed for polylactic acid (PLA) fibers. PLA is a biobased alternative to petroleum based polyethylene terephthalate (PET), which is the most widely used textile fiber. However, the hydrolytic degradation of PLA fibers under the conventional aqueous dyeing conditions limited its applications in textile industry. A new solvent dyeing process was developed using liquid paraffin as a nonaqueous dyeing medium. High quality dyed PLA fabrics were obtained without consuming water and auxiliaries. Minimal strength loss of dyed fibers was achieved by postheat setting treatment. The 3R principle (reduce, reuse, and recycle) was implemented to ensure the environmental friendliness of solvent dyeing process. The result of a 9-cycle reuse sequence demonstrated excellent color consistency of dyed PLA fabrics. The sustainability of our new dyeing process was quantified in the framework of environmental-health-social impact. The dyeing process sustainability index i...
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publication
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[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Net-zero and less polluting Industries",
"Advanced Materials",
"Circular systems",
"Manufacturing technologies"
]
] |
W2330400987
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Novel coding factors in heart disease
|
Heart failure has become a worldwide epidemic with more than 23 million people affected resulting in devastating consequences for patients and an enormous burden on health care systems. One in five heart failure patients dies within a year of diagnosis and survival estimates after diagnosis are 50% and 10% at 5 and 10 years, respectively. Despite intensive investigation, the molecular mechanisms leading to heart failure remain poorly understood. We will narrow this critical gap in knowledge by proposing a previously unattainable, comprehensive approach to define the genomic architecture and functional consequences of newly identified micropeptides from multiple classes of RNAs that previously were classified to be non-coding in cardiac biology and heart failure. Our approach is unique and novel in several ways. Thematically, our studies focus on novel classes of orphan peptides and their role in heart failure that have not been discovered previously. Our approach relies on innovative interdisciplinary efforts of scientists working in molecular genetics, genomics, computational biology, and cardiovascular research to identify and characterize pathophysiological pathways that converge on these novel peptides. We will identify these short peptides by using genome-wide measures of active translation and will harness unique clinical resources to ensure human relevance. Analysis of animal and cell models coupled with state-of-the-art biochemical and genetic tools will elucidate the function of newly identified micropeptides within the molecular and cellular pathways of cardiac biology and failure. Through these efforts we will discern fundamental causes of maladaptive responses in the heart and strategies to monitor and limit these.
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project/european
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[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
224364
|
Openrisknet: open e-infrastructure to support data sharing, knowledge integration and in silico analysis and modelling in risk assessment
|
Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks such as hazard prediction, toxicokinetics, and in vitro – in vivo extrapolations to support this transition. However, since these services are developed independently and provided by different groups world-wide, there is no standardized way how to access the data or run modelling workflows. To overcome the fragmentation of data and tools, OpenRiskNet will provide open e-Infrastructure resources and services to a variety of communities requiring chemical risk assessment, including chemicals, cosmetic ingredients, therapeutic agents, and nanomaterials. OpenRiskNet will combine the achievements from earlier projects for generating modeling and validation workflows, knowledge integration and data management as well as include all ongoing projects and important stakeholders through an associated partner programme. The main components of the infrastructure will be an interoperability layer added to every service to describe the functionality and guaranteeing technical and semantic interoperability, a discovery service, deployment options based on container technology, and packaging of the infrastructure into virtual instances. This will be complemented by training and support on integration of specific services based on prototype implementation, usage of standard file formats for data sharing including the generation of templates for data and metadata, as well as the harmonized usage of ontologies. Case studies will demonstrate the applicability of the infrastructure in productive settings supporting research and innovation in safer product design and risk assessment.
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Emerging enabling technologies"
]
] |
216724
|
Enhanced bioconversion of agricultural residues through cascading use
|
The BIOrescue project aims to develop and demonstrate a new innovative biorefinery concept based on the cascading use of spent mushroom substrate (SMS) supplemented by wheat straw (and other seasonal underutilised lignocellulosic feedstocks. i.e pruning residues, residual citrus peels and wastes). This new concept will avoid disposal and allow for the production of some biodegradable bio-based products and bioactive compounds that will help to replace the existing ones based on fossil resources.
The research will help to expand the business opportunities of the mushroom cultivation farms, and the know-how and business opportunities of all the partners involved. The main innovations are:
- Improved methods for the lab-based rapid (NIR) analysis of biomass
- Innovative two step fractionation of SMS
- Synergic effects for complete SMS glucan hydrolysis
- Innovative enzyme immobilisation strategy
- Development of highly efficient glucan-enzymes
- Novel lignin based nano- and micro-carriers
- Biopesticide production from monomeric sugars SMS derived and their packaging into nanocarriers
The consortium involved is a representation of some BIC members including a large company (Monaghan Mushrooms) which is leading the proposal and some SMEs (MetGen Oy and CLEA Technologies) and BIC associate members (University of Naples and CENER). Additionally other relevant partners with well-known expertise in their respective areas contribute to the objectives. Among them some research organisations (Imperial College of London and Max Planck Institute of Polymers) and Innovative SMEs (Celignis Limited, Zabala Innovation Consulting, Greenovate Europe and C-TECH Innovation Ltd). The synergies between large industry and SME’s go beyond the scope of this project. There is a lot of potential for collaboration between agricultural industry (Monaghan) and biotechnology (MetGen and CLEA) to provide novel solutions for continuous circular economy in large agriculture-based value-chains.
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project/european
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[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas",
"Circular systems",
"Bio-based innovation systems in the bioeconomy"
]
] |
215776
|
Targeting glioblastoma using combinatorial therapeutic nanovaccine
|
The proposal aims at the synthesis, characterisation and application of a novel therapeutic nanovaccine (TNVax) that holds multiple modules for targeting glioblastoma multiforme (GBM). The proposed TNVax formulation includes a gold nanocage core encapsulating Temozolamide (TMZ), coated with an extremophilic bacterial polysaccharide, mauran functionalised with anti-PD-L1 antibody and anti-CD133 antibody. The us of NVax nanoparticles (NPs) offers a combinatorial approach in killing GBM cells both by immuno- and chemo- therapeutically. Site-specific delivery of the payload will stimulate the host immune system and channel the immune cells to the target site. Functionalisation of the anti-PD-L1 antibody on drug-encapsulated
NPs would significantly alter the immune suppression caused by GBM cells on TNVax delivery. In addition to anti-PD-L1 antibody, the TNVax particles contain tumour specific monoclonal antibody that specifically recognizes CD133 antigen and facilitates strong binding. This approach would enhance the amount of antitumour activity offered by multiple means and thereby leaving a strong immune response against GBM based on antigen-antibody interactions. TNVax NPs will be synthesised and characterised using microscopic and spectroscopic techniques and then subjected to in vitro and in vivo evaluations. In vitro studies will be performed for drug release kinetics and cytotoxicity using immunofluorescence and FACS analysis. Induction of immune response by TNVax NPs will be evaluated using macrophage activation, induction of T-cell activity and cytokine production under in vitro conditions. The pharmacokinetic and pharmacodynamic studies
will be carried out and histopathological examinations performed using appropriate murine models induced with GBM cell lines. The potential outcomes of the proposed studies will help patients who suffer from early and advanced GBM by eradicating the disease permanently and leaving good immunological memory.
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project/european
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[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
219567
|
DRILLING TOOL
|
The invention relates to a drilling tool (10), in particular a rock drill, which extends along a longitudinal axis and comprises a drill head (24), an insertion end (16), a main body (32), a cover element (34), and a transport region (22) which is located between the drill head and the insertion end, and at least one transport channel (36) which extends along the transport region, said transport channel being located radially between the cover element and the main body. According to the invention, the cover element (34) comprises at least one interior region, which is located inside the main body, and at least one exterior region which is located outside the main body.
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
EP 2022061220 W
|
Iterología de Micaela Feldman/Etchebehere tras la guerra civil española: entre el insilio melancólico y el exilio de imaginación cosmopolita
|
RESUMENMicaela Feldman, autora de la obra bilingüe Ma guerre d’Espagne à moi/Mi guerra de España (1976), y conocida por su heterónimo “Mika Etchebéhère”, participó en la guerra civil española en una milicia del Partido Obrero de Unificación Marxista (POUM) que capitaneó hasta su disolución. El artículo analiza las relaciones entre sus prácticas de escritura y sus desplazamientos, a partir de la inquisición teórica de Michel Butor que se pregunta acerca de la iterología de escritores forzados al exilio. Este trabajo analiza entonces la iterología de transición de Micaela Feldman entre su insilio de posguerra en Buenos Aires (1940–1946) y su exilio posterior en París (1946–1992). El análisis se focaliza en su epistolario y sus publicaciones en Sur, y propone una lectura de cartas y “aguafuertes” a través de textos claves de los estudios judíos. Finalmente, la investigación echa luz sobre el trabajo de la memoria de la guerra que se concretó en la autoficción bilingüe de 1976.
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publication
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[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
W4213129929
|
A next generation telecommunication platform based on a nano-satellites constellation
|
Despite broad expansion of mobile networks, coverage gaps remain due to a lack of ICT infrastructure: 0.72bn people globally still lack access to basic voice and text services, with around 3.9bn (53% of the world’s population) lacking access to the internet at 3G speeds. The majority of these uncovered populations are low income and live in rural regions of Asia, Sub-Saharan Africa and Latin America. Current solutions for communication service in rural areas are based on large communication satellites (3,000 kg), leading to lengthy and costly development, as well as high costs of production, launch and operation. The central challenge in reaching uncovered communities is overcoming the unfavorable cost- benefit equation related to installing an operative communication infrastructure (with launch, maintenance and operating costs), whilst providing reliable and affordable communication.
With a sophisticated and revolutionary telecommunication network infrastructure leveraging nanosatellite technology, the Pearls constellation of 200 nano-satellites will provide affordable and reliable communication services anywhere within the Equatorial band. An advanced space technology, combined with a complex software infrastructure, provides a robust satellite communication platform that can be accessed at a low price and from any commercial cell phone. SAS’s goal is to provide affordable communication services and coverage to billions of people living along the equator who currently have no access to simple communication service.
During the feasibility assessment, a detailed scale-up plan to the constellation of 200 nano-satellites will be set up, and a supply chain will be established, as well as plan for the launch of 200 nano-satellites will be drafted. During the second phase of project, SAS will upgrade the software, scale-up the control and management platform, and will launch 5 nano-satellites in Space.
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Next generation internet",
"Emerging enabling technologies",
"Space, including Earth observation"
]
] |
985152
|
NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES CONFERRING ENHANCED HEAT TOLERANCE IN PLANTS
|
Methods and materials for modulating heat tolerance levels in plants are disclosed. For example, nucleic acids encoding heat tolerance-modulating polypeptides are disclosed as well a methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased heat tolerance levels and plant products produced from plants having increased heat tolerance levels.
|
patent
|
[
[
"Climate, Energy and Mobility",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Climate science and solutions"
]
] |
US 51570707 A
|
Automatic Auroral Detection in Color All-Sky Camera Images
|
Every winter, the all-sky cameras (ASCs) in the MIRACLE network take images of the night sky at regular intervals of 10–20 s. This amounts to millions of images that not only need to be pruned, but there is also a need for efficient auroral activity detection techniques. In this paper, we describe a method for performing automated classification of ASC images into three mutually exclusive classes: aurora , no aurora , and cloudy . This not only reduces the amount of data to be processed, but also facilitates in building statistical models linking the magnetic fluctuations and auroral activity helping us to get a step closer to forecasting auroral activity. We experimented with different feature extraction techniques coupled with Support Vector Machines classification. Color variants of Scale Invariant Feature Transform (SIFT) features, specifically Opponent SIFT features, were found to perform better than other feature extraction techniques. With Opponent SIFT features, we were able to build a classification model with a cross-validation accuracy of 91%, which was further improved using temporal information and elimination of outliers which makes it accurate enough for operational data pruning purposes. Since the problem is essentially similar to scene detection, local point description features perform better than global- and texture-based feature descriptors.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics",
"Emerging enabling technologies",
"Advanced computing and big data",
"Space, including Earth observation"
]
] |
W1964934007
|
Comparison of the Micronucleus and Chromosome Aberration Techniques for the Documentationof Cytogenetic Damage in Radiochemotherapy-Treated Patients with Rectal Cancer
|
The goal of the interdisciplinary Clinical Research Unit KFO179 (Biological Basis of Individual Tumor Response in Patients with Rectal Cancer) is to develop an individual Response and Toxicity Score for patients with locally advanced rectal cancer treated with neoadjuvant radiochemotherapy. The aim of the present study was to find a reliable and sensitive method with easy scoring criteria and high numbers of cell counts in a short period of time in order to analyze DNA damage in peripheral blood lymphocytes. Thus, the cytokinesis-block micronucleus (CBMN) assay and the chromosome aberration technique (CAT) were tested.Peripheral blood lymphocytes obtained from 22 patients with rectal cancer before (0 Gy), during (21.6 Gy), and after (50.4 Gy) radiochemotherapy were stimulated in vitro by phytohemagglutinin (PHA); the cultures were then processed for the CBMN assay and the CAT to compare the two methods.A significant increase of chromosomal damage was observed in the course of radiochemotherapy parallel to increasing radiation doses, but independent of the chemotherapy applied. The equivalence of both methods was shown by Westlake's equivalence test.The results show that the CBMN assay and the CAT are equivalent. For further investigations, we prefer the CBMN assay, because it is simpler through easy scoring criteria, allows high numbers of cell counts in less time, is reliable, sensitive, and has higher statistical power. In the future, we plan to integrate cytogenetic damage during radiochemotherapy into the planned Response and Toxicity Score within our interdisciplinary Clinical Research Unit.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
W1590692894
|
Translation of adaptive optical microscopy expertise to the commercial domain
|
Adaptive optics (AO) is an important technology for high-resolution microscopy that overcomes imaging problems when focusing inside biological specimens. Through the ERC Advanced Grant AdOMiS we have developed and experimentally validated new, broadly applicable AO tools that make integration of this technology more practical for a range of different microscopy techniques. We have also accumulated significant know-how about effective implementation of this technology. The challenge now is to translate these laboratory-based methods and know-how outside the academic research environment. This project will facilitate access to the products of our research to potential research and commercial adopters so that they can successfully deploy our AO methods in their systems.
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Manufacturing technologies"
]
] |
623450
|
METHOD FOR PREPARING AL2O2 COATING ON SURFACE OF SILICON -NITRIDE -CUTTING TOOL BY USING PVD,AND COMPOSITE COATING METHOD
|
A method for preparing an aluminum-oxide single-layer coating or multi-layer coating on the surface of silicon-nitride ceamic cutting tool by using a Physical Vapor Depositon (PVD) process. There are two methods for preparing the aluminum-oxdie coating by using the PVD techonology: one is depositing an aluminum-oxide layer through reactive sputtering of Al target by using a bipolar pulse power source and a Dual Magnetron Sputtering (DMS) technology in the O 2 atmosphere or Ar-O 2 mixed atmosphere; the other one is sputtering, by using DMS technology in the Ar atmosphere or Ar-O 2 mixed atmosphere, an aluminum-oxide ceramic target conductive doping, and then preparing the aluminum-oxide coating. With the two methods, a single-layer aluminum-oxide coating, a nitride and aluminum-oxide composite coating, or a multi-layer or nano composite coating obtained by alternately depositing nitride and alumimum oxide is prepared, the aluminum-oxide being ±-Al 2 O 3 , ²-Al 2 O 3 , ³-Al 2 O 3 , or amorphous Al 2 O 3 . The hard nitride coating in the multi-layer composite aluminum-oxide coating comprises a two-element nitride coating, a three-element nitride coating, multi-element nitride coating, or a multi-layer composite thereof of a nano coating.
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patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
EP 13867666 A
|
When History Meets Molecular Medicine: Molecular History of Human Tubercolosis
|
Tuberculosis represents one of the humankind’s most socially devastating diseases. Despite a long history of medical research and the development of effective therapies, this disease remains a global health danger even in the 21st century. Tuberculosis may cause death but infected people with effective immunity may remain healthy for years, suggesting long-term host-pathogen co-existence. Because of its antiquity, a supposed association with human settlements and the tendency to leave typical lesions on skeletal and mummified remains, tuberculosis has been the object of intensive multidisciplinary studies, including paleo-pathological research. During the past 10 years molecular paleo-pathology developed as a new scientific discipline allowing the study of ancient pathogens by direct detection of their DNA. In this work, we reviewed evidences for tuberculosis in ancient human remains, current methods for identifying ancient mycobacterial DNA and explored current theories of Mycobacterium tuberculosis evolution and their implications in the global development of tuberculosis looking into the past and present at the same time. Key words : Tuberculosis - Mycobacterium tuberculosis complex - Mycobacterium tuberculosis - paleopathology - ancient DNA
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publication
|
[
[
"Health",
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Health throughout the life course",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W2468796788
|
Printing personalised medicines on demand
|
Methods of pharmaceutical manufacturing are likely to change dramatically over the coming years. Driven by the knowledge and technology that is already available in other sectors, the processing of drugs into dosage units can be transformed into a “pharmacy-on-demand” process that allows individual dosing, based on criteria relevant for the effective use of the drug in an individual patient. One approach to achieve “pharmacy-on-demand” is the use of inkjet printing technology to deliver an exact dose of drugs on porous substrates. This proof-of-concept project is based on knowledge we acquired during my ERC AdG project on processes of printing on paper using inkjet printing. We will demonstrate the viability of ""printing"" highly accurate amounts of a solution containing levothyroxine, prescribed for hypothyroidism, onto a porous tablet. Modelling tools will be combined with cutting-edge characterization technologies to push the understanding of printed drug-containing inklike solutions in porous dosage unit matrices. This project will transfer pharmaceutical formulation and product design of individual dosage forms with the use of inkjet printing technique to the pharmaceutical community. They can work on clinical approval tests of the developed oral dosage forms and move these products toward clinical use. The patients will benefit directly from development of this production technique, because a much more effective and targeted medication can be provided. The next step will be the development of the inkjet printing technique for other personalized medicines such as pain killers for children, hormones, biomacromolecules, psychoactive and anticancer drugs. Individually-dosed medicines will allow for substantial decrease of drug waste and thus overall reduction of medical expenses.
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project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
629273
|
Body-cavity probe with body conformable member
|
A probe insertable into a body cavity for applying an electrical stimulation to tissue therein includes a flexible hollow member of biocompatible material to enable the member to be inserted into the body cavity and to substantially conform to its inner surface, and thereby, to contact the tissue therein to be stimulated. A portion of the outer surface of the hollow member is electrically conductive to enable an electrical voltage to be applied thereto for electrically stimulating the tissue within the body cavity contacted by the electrically conductive surface. The probe may also include a transparent section and an optical sensor, such as an oximeter, for optically examining tissues within the body cavity.
|
patent
|
[
[
"Health"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
US 63112300 A
|
Non-carcinogenic risk assessment of exposure to heavy metals in underground water resources in Saraven, Iran: Spatial distribution, monte-carlo simulation, sensitive analysis
|
Groundwater aquifers are considered the second most abundant water supply for drinking water all over the world. In Iran, ground waters are commonly employed for drinking water, irrigation, and industrial purposes. Heavy metals (HMs) pose human concerns about the groundwater contamination; these pollutants are recognized to be capable of bio-accumulation, long persistence in the natural environment, and toxic effects. In the present research, the content of HMs: Chromium (Cr), Cadmium (Cd), and Lead (Pb) were detected in 89 water samples collected in 2018 by underground water supplies (active wells) of Saravan city. Hazard Quotient (HQ) and Monte Carlo Simulation approach with 10,000 repetitions were applied to discover the human non-carcinogenic impacts of HMs in four groups of ages (adults, teenagers, children, and infants) of consumers. The concentrations of Cr, Pb, and Cd were in the range of 0.49-20, 0.1 to 58.34, and 0.11-12.8 μg/L, respectively. The mean HQ calculated due to exposure to Pb (0.0018-0.0023), Cr (0.0112-0.0186), and Cd (0.0370-0.0615) were lower than one. The findings of sensitivity analysis revealed that HMs concentration had the most contribution effect on human non-carcinogenic risk analysis in four different exposed populations. This study could assist researchers to perform more comprehensive studies with more samples. Therefore, further research is required for decision-makers to plan proper measurements properly.
|
publication
|
[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Non-communicable and rare diseases",
"Environmental and social health determinants"
]
] |
W3197402760
|
Screening, characterisation and engineering of carbohydrate harvesting machineries of microbial ecosystems
|
Mammals rely entirely on their symbiotic microorganisms to digest complex glycans, issued from dietary fibers, yeasts, and the host itself. To that purpose, gut bacteria have evolved sophisticated machineries to face the structural diversity and complexity of carbohydrates, consisting of gene clusters coding for carbohydrate-hydrolysing, -binding and -transporting proteins. Since the last decade, functional metagenomics has proved to be a highly powerful technique to boost the discovery of new protein families involved in these multi-proteic systems from the vast world of uncultured bacteria, which represents the majority of gut microorganisms. By using a multidisciplinary approach, integrating genomic, metagenomic, functional and structural data, CaTSYS will decipher the structure-function relationships of novel key carbohydrate active enzymes and transporters recently discovered by functional exploration of the human and bovine gut microbiomes. Their role in carbohydrate harvesting pathways will be investigated and optimised by combinatorial engineering, thanks to the development of an original high-throughput screening approach, to render heterologous hosts capable of internalising and breaking down a large diversity of complex carbohydrates. Overall, CaTSYS will provide a promising framework to overcome future challenges in biotechnology, for the conversion of carbohydrate polymers into biosourced chemicals and/or high-added value compounds.
|
project/european
|
[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Emerging enabling technologies",
"Circular systems",
"Advanced Materials"
]
] |
171211
|
Single molecule bio-electronic smart system array for clinical testing
|
Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
892827
|
Noise reduction in large port cities in the cross-border maritime program
|
The general objective of this project is to improve the sustainability of commercial ports by contributing to the reduction of noise pollution. It will build some infrastructure and invest in noise mitigation to carry out studies and assess their effectiveness, replicable in all ports of the cooperation area. This will make it possible to reduce heavy-duty road traffic generated by port activities and boat moorings, the main sources of disturbance induced by port sound sources, thus benefiting the neighbouring urban population. The project will implement actions after an initial acoustic climate survey and taking into consideration the grievances of the residents received by port management bodies and the public institutions in charge. In order to operate correctly and efficiently, RUMBLE will apply a monitoring strategy with the following features: 1) connected to the effectiveness of the mitigation works carried out with project funds in the pilot areas of Cagliari, Livorno and Ajaccio 2) aimed at evaluating the effectiveness of a large-scale project already carried out with its own funds in the Port of Genoa 3 ) defining the best actions to be implemented in the future in the Nice metropolitan area port. Focus groups and events will involve the target groups in all phases of the project, also to validate the results. These will include public bodies in charge of acoustic monitoring and planning, port companies and residents, also represented by Committees. The Network with the leaders of the other projects will ensure that the project can be repeated and transferred to other cross-border port facilities; the same will be carried out at European level through presentations by partners at institutional events and partner Universities before the international scientific community.
|
project/regional
|
[
[
"Climate, Energy and Mobility",
"Culture, Creativity and Inclusive Society",
"Civil Security for Society"
]
] |
[
[
"Communities and cities"
]
] |
interreg_3071
|
Simax – translation machine for sign language
|
The Austrian SME SignTime is optimally combining its expertise on translation of content into sign language and on development of ICT tools in this context.
SignTime`s recent innovative solution SiMAX is a translation “machine”: The software is operated by a human translator who only needs to adjust translations suggested by an intelligent, learning algorithm based on a “learning” database. The resulting translation is then signed by an avatar and delivered as video.
This is very cost efficient compared to conventional production of translation videos in a studio with human translators signing.
Among all approaches researched so far in academia the SiMAX technology is closest to market and the only one reaching a feasible quality of facial expressions and emotions essential for understanding due to their grammatical meanings in sign language.
Business opportunities are enormous associated with any information needed to be made accessible to the deaf community (by integrating the translation video next to the original content): TV, film, internet, other media. Upcoming accessibility regulations favour market growth and demand.
Thus, this project fits perfectly with our overall strategy as well as with the requirements of this SME call, adding a completely new, market changing solution.
The feasibility study aims to pave the way to market introduction covering: Development of demonstrations, collecting technical and economic feedback from key market segments, from experts and the deaf community and incorporating all insights including market study results into a technology adaptation plan and a detailed business and market entry plan.
Apart from providing significant growth options to the company, SiMAX can essentially contribute to increase accessibility to information society for the deaf community thus promoting inclusion and social cohesion.
|
project/european
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Artificial intelligence and robotics",
"Emerging enabling technologies",
"Next generation internet"
]
] |
173489
|
HIGHLY WIND RESISTANT PRE-ASSEMBLED RELOCATABLE BUILDING STRUCTURE WITH CONTINUOUS SHEET OUTER WALL
|
In order to provide a pre-assembled, relocatable building structure which can be transported by road from one site to another, a metal skeleton (318) which is formed of 6 x 2 inch rectangular cross section hollow steel tubing, is welded together and provided with horizontally extending anchor brackets (324) at the bottom of each vertically extending column member (330). These anchor pads (324) allow the building to be lowered onto foundations in which anchor bolts (104) are imbedded, and bolted in place. The foundations are formed so as to take the form of continuous elongate footers (102) which break the passage of wind which tends to flow sideways under the housing structure. A shallow crawl space (105) can be formed between the foundation footers to facilitate service connections. Metal brackets (301, 302, 303, 304) are used to enclose or encapsulate the edges of the panels in a manner which prevents the direct contact with the wind.
|
patent
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Circular systems",
"Manufacturing technologies"
]
] |
CA 2236859 A
|
Coexistence on the boundary of chaos
|
This project is an exploration of the essence of chaos. Chaos and chaotic systems are by their very nature unpredictable. Paradoxically, the manner in which systems transition into chaotic regimes is highly structured and rigid. This contradiction can be explained mathematically through an elegant process called renormalization. Renormalization is like a microscope which can be used to observe the shape of fractals that appear on the boundary of chaos. One aspect of the structure of chaos is that such fractals on a large scale may look nothing like each other, but as the magnification factor on the microscope is increased they look more and more alike. This is expressed by saying that renormalization converges. Convergence of renormalization has been a consistent theme since the very inception of chaos theory, thus it was believed that the structure of chaos was thoroughly understood. In an unexpected twist, the applicant recently made the groundbreaking discovery that there are natural systems for which the renormalization sometimes is convergent and at other times degenerate. This reveals that the structure of chaos in fact is much more intricate than was previously imagined.
Building on this radical discovery, the proposed project marks the start of an entirely new chapter in chaos theory. The objective is to explore this new notion of coexistence of convergent and degenerate behavior of renormalization, and to explain the consequences it has on the structure of chaos. The research will benefit the field of dynamical systems by expanding the knowledge of chaos into new and unexplored territory. It will also expand the reach of renormalization closer to systems which have relevance for the natural sciences as well as mathematics. The project hinges on the applicant joining the supervisor and members of the dynamical systems group at Imperial College, who are leading global experts, in order to learn cutting-edge techniques and spark new discussions.
|
project/european
|
[
[]
] |
[
[]
] |
219754
|
Recognizing Context for Privacy Preserving of First Person Vision Image Sequences
|
The constant increasing evolution of life-logging wearable devices, as well as the fast grow of their market, has introduced relevant changes in the acquisition, storage and automatic understanding of images and videos. Along with the novel users’ opportunities, this technology is introducing a large amount of privacy-related concerns, mainly regarding the unaware or unwilling contexts subject that could get recorded by a life-logging device. In this work, we devise an approach to help life-logging wearable devices enforcing restrictions for context-related users’ privacy preservation. The proposed approach joins different technological innovations, from computer vision techniques to bluetooth beacon technology and network security.
|
publication
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Key digital technologies",
"Artificial intelligence and robotics",
"Emerging enabling technologies"
]
] |
W2763464222
|
Photomechanical writing of cell functions
|
Generating artificial organs and tissues from stem cells would revolutionize regenerative medicine and open the door to controllable, biology-based robotics. These systems require a physical understanding of cells, specifically their dynamic and adaptive responses to external forces. This “mechanotransduction” is already known to control important cellular functions, and even stem cell differentiation. With the project proposed here, I plan to bring our quantitative understanding of force-controlled cell functions to a new level by a challenging and novel photomechanical cell stimulation approach. It will combine new materials containing photoswitchable molecules with a complex optical system employing intense laser light pulses. By pulsing the laser, we can apply controllable force stimuli on cells through a conformational change of the photoswitchable molecules. I hypothesize that cell functions, such as adhesion, migration and differentiation, have a huge systematic dependency on frequency, duration, history, and intensity of the force stimuli. Importantly, the method I propose applies forces to cells solely via light and does not require genetic modifications. Using this novel strategy for photomechanical stimulation of cellular proteins, we will be able to collect previously unobtainable physical information within cells on multiple size scales, from the single molecule to tissue level. Using the laser like a pen, we will be able for the first time to write cell functions in 3D, imitating the growth of the cellular scaffolds in living creatures: a completely new means of photomechanically controlling multicellular structures. Ultimately, the tools and materials we study in this interdisciplinary project will allow for the writing of multicellular structures in vitro and in vivo by force-induced mechanotransduction in stem cells. It will lead to a paradigm-shift in many fields, from biophysics to regenerative medicine, synthetic biology and biohybrid robotics.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
624701
|
Experimental Research about Adjusting the Exposure Time and Power Level of Microwaves for Industrial Applications
|
This paper shows some possibilities to adjust the exposure time and output power of a given microwave device according to the process to be executed, taking into account the special operating conditions of the magnetrons and the efficiency of the microwave device. Since the exposure time is rather easy to set by means of timers, the microwave power level is difficult to modify because of the magnetron requirements voltage, current, magnetic field which must be carefully observed in order to ensure reliable operation. The research has been carried out at the University of Oradea and INCDTIM Cluj-Napoca, during the activities of the Microwave Collective of the University of Oradea and during the preparation of the doctoral thesis of Mr.Ursu.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
W2005947734
|
Financial leverage and corporate taxation: evidence from German corporate tax return data
|
To estimate the impact of profit taxation on the financial leverage of corporations, this study uses a pseudopanel constructed from comprehensive corporate tax return microdata for the period 1998–2001, which saw the introduction of major corporate tax reform in Germany. Financial leverage refers to the ratio of long-term debt to total capital. The endogeneity of the firm-specific marginal after-financing corporate income tax rate is controlled for by an instrumental variable approach. The instrument for the observed marginal tax rate is the counterfactual tax rate that a corporation would have faced in a particular period had there been no endogenous change, triggered by the tax reform, of its financial leverage and tax base. This counterfactual tax rate is derived from a detailed microsimulation model of the corporate sector, based on tax return microdata. The marginal tax rate has a statistically significant and relatively large positive effect on corporate leverage; for firms reporting positive profits, an increase of the marginal tax rate of 1 % would increase the financial leverage by approximately 0.7 %, on average. The debt ratio is less responsive to tax incentives for small corporations and firms facing high economic risks.
|
publication
|
[
[]
] |
[
[]
] |
W2029408879
|
Capacity-Building and transnational cooperation for national contact points (ncps) for the eic and access to risk finance – access2eic
|
ACCESS2EIC is a 16-months coordination and support action aimed to empower and facilitate transnational cooperation within the network of National Contact Points - NCPs focused on the Horizon 2020 European Innovation Council - EIC Pilot and the specific objective Access to Risk Finance - ARF. It involves a consortium made of formally appointed NCPs under ‘Future and Emerging Technologies – FET’, ‘Innovation in SMEs – SME’ and ‘Access to Risk Finance - ARF’ areas of Horizon 2020.
Overall, the network will aim at:
- developing an improved, more consistent and professionalized NCP service across Europe, thereby helping simplify access to EIC Pilot calls, and lowering the entry barriers for newcomers;
- identifying and sharing good practices and raising the general standard of support to EIC and ARF programme applicants in close collaboration with other NCPs and EU networks, taking into account the novelties of those instruments and the diversity of actors that make up their constituency.
|
project/european
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies"
]
] |
3743638
|
Creep behavior of high-pressure die-cast Mg-4Al-4La-0.4Mn alloy under medium stresses and at intermediate temperatures
|
Abstract Tensile creep behavior of the high-pressure die-cast Mg-4Al-4La-0.4Mn alloy under stresses of 50–100 MPa and at 150–225 °C was thoroughly investigated. This alloy exhibits a stress exponent of approximately 6 and the activation energy Q falls within the range of 80–120 kJ/mol at 150–200 °C. From fitting results, the commonly adopted threshold stress approach is not suitable for ALa44 alloy, and the normalized stress exponent is approximately 7, suggesting that creep deformation of ALa44 alloy was controlled by low-temperature dislocation climb (core diffusion). Furthermore, the microstructural analysis results indicate that the rate-controlling creep mechanism of ALa44 alloy is dislocation climb, but the cell boundary disintegration and the dislocation cross-slip also assisted deformation during creep processes.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
W1614904978
|
Lessons from water scarcity of the 2008–2009 Gwangdong reservoir: needs to address drought management with the adaptiveness concept
|
Numerous publications document increasing consensus in the scientific community that climate change will increase the severity and frequency of drought. However, constructing large infrastructures is often viewed as an unreliable and inefficient option in dealing with the problem of drought, owing to unpredictability of climate change. This study aims at illustratively presenting that there is much room to improve drought management without resorting solely to infrastructure options. The adaptiveness concept is first explained to examine the reasons of failure in drought management and appropriate options from the viewpoint of a systems approach. Thereafter, a Korean water scarcity case is defined as the system dynamics model. The model is implemented to include movement of water via the reservoir and water supply facilities, the operating rules of the reservoir, and the relation between water scarcity and customer stress. Simulation results demonstrate that adaptiveness of drought management was low because of untimely or limited options of the reservoir operator. They also show that most customer stress could be largely mitigated by two options chosen from the adaptiveness concept. It is finally concluded that drought management needs to be addressed with consideration of the adaptiveness concept before deciding solely on expansion of infrastructure upon facing challenges due to climate change.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Climate science and solutions",
"Communities and cities",
"Energy supply"
]
] |
W1992395809
|
Dna methylation dynamics during gastrulation
|
A fundamental aspect of biology is the understanding of how cell fates are established and maintained. Although it is widely accepted that epigenetic reprogramming is a central process of mammalian development, one of the most intriguing questions that remains unanswered is how DNA methylation marks contribute to cell differentiation and lineage commitment. By combining, novel single cell genomics techniques, CRISPR/dCas9 technology and innovative analytical approaches, this project will uncover the links between DNA methylation, gene expression and cell fate decisions during mouse gastrulation. This information will be used in a novel way to identify methylation signatures responsible for the stable repression of pluripotency, which has great potential to advance the development of safe iPS cells. Furthermore, this proposal will implement two innovative approaches utilising single cell DNA methylation patterns to reconstruct lineage trajectories of individual cells. This project capitalises on the unique combination of my novel analytical approaches, my background in DNA methylation analysis and evolutionary biology together with the extensive expertise in single cell techniques and developmental biology of the host lab. This multidisciplinary proposal will provide critical insights into how information is encoded in the epigenome and what this information can tell us about a cell’s history within a developing organism. These results will significantly advance the field of epigenetics, developmental and stem cell biology. Finally, the knowledge and skills gained from this project combined with my scientific and personal development will hopefully open up exciting career possibilities with the long-term goal to establish my own research group in Europe.
|
project/european
|
[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Health throughout the life course",
"Tools, technologies and digital solutions for health and care, including personalised medicine",
"Non-communicable and rare diseases"
]
] |
220179
|
Light Scattering from 3-D Nanoscale Disordered Media
|
Random volume and surface scattering is a topic, which has been studied in many domains such as optical wave propagation in turbulent media, plasmonics and surface optics. Useful phenomena in the optical range can be produced by random media with randomly rough surfaces. Designing these disordered slabs with rough surfaces can produce new optical com- ponents, which can transmit or scatter optical fleld with specifled angular, spatial or spectral properties. Understanding how light interacts with disordered matter is a fundamental issue in optoelectronics and photonics and has huge consequences in communications, imaging and sensing. In this paper, we consider a three-dimensional disordered medium with randomly rough interfaces. This structure describes a device based on metallic nanoparticles embedded in insula- tors or dielectric media. We present a theory of transport based on the Bethe-Salpeter equation. The calculation of the intensities scattered by the considered structure for the ladder and most- crossed contributions is given by a Green tensor, which satisfles a Bethe-Salpeter equation. Random media have attracted much attention, not only in electromagnetic wave propagation, but also in solid-state physics. The governing equation can be written in the form of a Bethe- Salpeter equation. The problem is then reduced to flnd a good approximation to the solution of this equation. For a three-dimensional system composed of a random medium bounded by two randomly rough surfaces, the Bethe-Salpeter is constructed in order that the medium and the boundaries are treated on the same footing. This unifled Bethe-Salpeter equation enables us to obtain a general expression, whatever the choice of the scattering operators used at the boundaries. The Quasi-Crystalline Coherent Potential Approximation (QC-CPA) is taken into account for the contribution of the random medium, which is made of spherical particles of given permittivity in a homogeneous background medium. The boundaries are described by random functions. In (1{ 4), we developped a general formalism based on Green functions to calculate the difiuse intensity. With these Green functions, we can separate the contributions of the surfaces and the volume. The procedure is to write the Maxwell equations as an integral form with the help of the Green functions and to apply the Wigner transform to the derived equation. Starting from the wave equation, we are able to take into account new contributions to the scattered intensity such as enhanced backscattering and the correlations between the scatterers which can not be introduced by the phenomenological radiometric approach. We use an unifled approach to describe how the waves interact with the randomly rough boundaries. The main advantage of this approach is that the equations we obtained are very similar to the equations used to describe the electromagnetic waves scattered by an inflnite random medium.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Emerging enabling technologies",
"Advanced Materials"
]
] |
W2056709335
|
In@natura - bridleways: connecting structures and tourist enhancement in the Cormor valley
|
Also on the basis of other experiences in the field of naturalistic resources enhancement, the project intends to provide tourists in the cross-border area with new entertainment opportunities by means of itineraries that can be enjoyed on foot, by bicycle, mountain bike or on horseback. Specifically, “In@natura” is a naturalistic track winding across the wilderness for around thirty km, along the Cormor stream in the municipalities of Tavagnacco, Pagnacco, Tricesimo, Colloredo di Monte Albano, Cassacco, Treppo Grande and Buja. This project also connects to the Slovenian area comprised between Bovec and Tolmino, where another waterway - Isonzo-Soča - joins together green landscapes, rich in ancient cultural and eno-gastronomic traditions. Secondary roads are made available to users in a context of environment-friendly tourism, through the creation of non-invasive and ecological infrastructures. Along the track riding schools, farmhouse accommodations and farms are to be found where tourist can rest, eat and buy typical produce. In order to enhance the use of rural spaces on the part of the two communities and promote this route, the project envisages the publication and distribution of brochures, a DVD and the creation of a website, the organisation of workshops and the participation to fairs and promotional events in Italy and Slovenia. Lastly, the project aims at establishing a permanent network of contacts among the partners to encourage greater economic and tourist development in the areas of reference.
|
project/regional
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Social and economic transformations",
"Culture, cultural heritage and creativity"
]
] |
interreg_1919
|
VAPOR SOURCE HAVING LINEAR APERTURE AND COATING PROCESS
|
A linear aperture (70) deposition apparatus (60) and process are provided for coating substrates with sublimed or evaporated coating materials. The apparatus and process are particularly suited for producing flexible films having an optical interference coating with a very high surface thickness uniformity and which is substantially free of defects from particulate ejection of a source material. The apparatus includes a source box (62) containing a source material (64), a heating element (82) to sublime or evaporate the source material, and a chimney (66) to direct the source material vapor from the source box to a substrate (72). A flow restricting baffle (74) having a plurality of holes is positioned between the source material and the substrate to confine and direct the vapor flow, and an optional floating baffle (76) is positioned on the surface of the source material to further restrict the vapor flow, thereby substantially eliminating source material spatter.
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
US 9926904 W
|
ν¯linduced pion production from nuclei at∼1 GeV
|
We have studied charged current $\bar\nu_l$ induced one pion production from $^{12}$C and $^{16}$O nuclear targets at MiniBooNE and atmospheric antineutrino energies. The calculations have been done for the incoherent pion production process as well as for the pions coming from the hyperons in the quasielastic production of $\Lambda$ and $\Sigma$. The calculations are done in the local density approximation. For the inelastic processes the calculations have been done in the $\Delta$ dominance model and we take into account the effect of Pauli blocking, Fermi motion of the nucleon and renormalization of $\Delta$ properties in the nuclear medium. The effect of final state interaction(FSI) of pions is also taken into account. For the hyperon production, the nuclear medium effects due to Fermi motion and FSI effects due to hyperon-nucleon scattering have been taken into account. These results may be quite useful in the analysis of SciBooNE, MicroBooNE, MINER$\nu$A, and ArgoNeuT experiments when the pion analysis is done by using antineutrino beams.
|
publication
|
[
[]
] |
[
[]
] |
W1537085575
|
Preservice Teachers’ Perception and Use of Personal Learning Environments (PLEs)
|
Personal learning environments (PLEs) are Web 2.0 tools and services by which users’ access, construct, manage, and share educational contents in order to meet their learning needs. These environments enable users to manage their learning according to their own personal preferences. They further promote socialization and collaboration with their broad user networks and interaction facilities. In this study, with a case sample from a public university in Turkey, student teachers’ PLE use and their perceptions regarding these environments are examined. For data collection, the PLE Perception Scale and PLE Use Scale developed by the researchers were used. It was observed that all participants used various PLEs and found them easy and practical on the whole. However, it was found that this utilization mostly had the aim of access and sharing knowledge in learning, while use of constructing and managing it remained limited. Emailing, social networking, file sharing, video sharing, Internet searching, and social encyclopedias were found most commonly used PLEs. Our findings also show that gender and grade level do not have an effect on the perception and use of PLEs.
|
publication
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Emerging enabling technologies"
]
] |
W2289152028
|
LANDCARE MEDiterranean cross-border network for local rural governance improvement to enhance rural waste management
|
Project in brief _x000D_
_x000D_
The prevention of rural waste production and the recycling of material deriving from human activities in rural communities are currently not well developed in the Mediterranean area. Residuals from breeding and agriculture are often treated all together, even though differentiating waste would prove much easier than in the case of industrial or urban waste for instance. Due to the increase in waste generation and the consequences for local populations (health issues, pollution of soil and water resources), many Mediterranean territories share the need to develop sound environmental systems for the management of rural waste. LANDCARE MED project aims to provide the necessary tools and methodology for local authorities (i.e. rural villages) in order to develop integrated strategies and policies in the field of rural waste management. In particular, the actors involved in the project will implement a system where any kind of residual in livestock and agriculture related activities has a reasonable and efficient way of reusing. This objective will be achieved through a small-scale rural waste management approach and the exploitation of innovative technologies, which both allow to enhance the role of the farmer from source of the problem to key factor of its solution by changing its role from passive actor to active stakeholder. _x000D_
_x000D_
Specific objectives _x000D_
_x000D_
• To develop integrated strategies and policies in the field of rural waste management _x000D_
• To improve cooperation for exchanging good practices and experiences among local administrations in the field of environmental legislations and policies on rural waste management
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project/regional
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[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas",
"Circular systems",
"Biodiversity and natural resources",
"Environmental observation"
]
] |
interreg_2038
|
Rethink
|
Science communication is at a pivotal stage in its evolution due to the emergence of digital communication platforms that are not only presenting new opportunities but are also leading to new challenges. RETHINK will provide an unprecedented view of the new science communication landscape to reveal the barriers and inequalities that stand in the way of open and reflexive connections between science and society. It will also present the way forward, encouraging evidence-based transformations in science communication practice as well as guiding relevant policy to further open Research & Innovation (R&I) to society.To achieve this, RETHINK will provide a 360° view of the current science communication landscape. It will map current science communication activities across Europe, including those taking place in the currently uncharted digital sphere. It will seek input from R&I stakeholders who are currently disengaged with science communication.
Outputs will be new ways of training those who engage in science communication, including those underserved by current training - such as bloggers and social media commentators. There will be online briefs aimed at changing current science communication practices to break down barriers preventing open R&I and reach underserved audiences across the EU. Strategies will be developed to improve individual and collective sensemaking by enhancing its openness and reflexivity. Guidance on policy will also be provided to create an environment that encourages open R&I. All of these outputs will be open access, as will the data generated during the research process to encourage a broad discussion and maximise uptake.
RETHINK will bring about meaningful, long-term change in science communication to maximise the opportunities and overcome the challenges of digitalisation, allowing the sector to help society meet key challenges across the European community and beyond.
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project/european
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Social and economic transformations",
"Democracy and Governance",
"Culture, cultural heritage and creativity"
]
] |
892877
|
Endoscopes and robots for tight surgical spaces: use of precurved elastic elements to enhance curvature
|
Many applications in medicine require flexible surgical manipulators and endoscopes capable of reaching tight curvatures. The maximum curvature these devices can achieve is often restricted either by a strain limit, or by a maximum actuation force that the device's components can tolerate without risking mechanical failure. In this paper we propose the use of precurvature to bias the workspace of the device in one direction. Combined with axial shaft rotation, biasing increases the size of the device's workspace, enabling it to reach tighter curvatures than a comparable device without biasing can achieve, while still being able to fully straighten. To illustrate this effect, we describe several example prototype devices which use flexible nitinol strips that can be pushed and pulled to generate bending. We provide a statics model that relates the manipulator curvature to actuation force, and validate it experimentally.
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publication
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[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
W2303878226
|
CONTROLLED CRINKLE DIAPHRAGM PUMP
|
Crinkle diaphragm pump (1) comprising: – a body (2) inside which there is an internal chamber (2a) comprising an inlet opening and an outlet opening for fluid (22); – a flexible diaphragm (3) placed inside the chamber in which it can crinkle. The pump further comprises: – an actuating mechanism (4) comprising at least one motor (M) and a mechanical connection piece (41) connecting the motor (M) to the first edge of the diaphragm (31) in order to move it in a reciprocating motion. The pump also comprises a detection device (5) for detecting at least one value indicative of a movement of the diaphragm (3), a power supply unit delivering an electric power supply signal to the motor on the basis of a detection signal (Sd).
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
EP 2018083704 W
|
Magnetically assisted tissue engineering technologies for tendon regeneration
|
The poor healing ability of tendons, which play a critical role in the musculoskeletal system, as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. However, the limited knowledge on tendon development and healing processes has hindered the design of TE procedures that more closely recapitulate tendon morphogenesis. Extending beyond the state-of-the-art, MagTendon will explore conventional and innovative tools such as multimaterial 3 dimensional (3D) bioprinting to design magnetic responsive systems mimicking specific aspects of tendon tissue architecture, composition and biomechanical properties, which, combined with adequate stem cells, will render appropriate behavioural instructions to stimulate the regeneration of tendon tissue. Stem cell bioengineering approaches based on superparamagnetic nanoparticles (SPMNs), namely cell sorting, mechanoreceptors targeting and cell programming, will be used to unveil the cellular signalling pathways that trigger the tenogenic differentiation of the widely and easily obtained human adipose derived stem cells. Simultaneously, the 3D cell-laden magnetic system shall enable sophisticated 3D tissue models to unravel mechanisms behind tendon homeostasis and repair that will support the base knowledge to establish rational design criteria for the biofabrication of living tendon substitutes with the adequate signaling and structural cues to recapitulate tendon tissue developmental patterns. Therefore, the ground-breaking nature of the research proposed relies on the development of disruptive technological concepts for obtaining unique cell-laden 3D magnetically responsive systems that recapitulate key features of the native tissue and that can be further remotely modulated both in vitro and in vivo by the application of external magnetic stimuli, offering the prospect of tendon regeneration as opposed to simple tissue repair.
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project/european
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[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
225734
|
Nondestructive Evaluation of Early Contact Fatigue Using Eddy Current Pulsed Thermography
|
Cyclic loading can lead to fatigue damage on the surface or subsurface of a gear tooth. In order to evaluate the contact fatigue damage, this paper applies eddy current pulsed thermography (ECPT) for fatigue damage characterization at different intervals of the loading cycle. The challenging task of fatigue evaluation is one of solving the qualitative microstructure state characterization before microcrack initiation. This paper proposes the thermooptical flow entropy tracking method to trace the heat flow and characterize the degree of fatigue damage while in this status no macrodefects appears using ECPT. In addition, the thermooptical flow is mathematically modeled to yield several desirable unique properties to evaluate minor variations in the microstructure of the material during the fatigue process. The nondestructive evaluation of fatigue damage with ECPT thermooptical flow is derived. The relationship between the entropy of thermooptical flow and the degree of contact fatigue at an early stage is established. The experimental study validates that the proposed method can detect and characterize the implicit damage and that the entropy of thermooptical flow is highly correlated with fatigue cycles which has the potential to evaluate the degree of fatigue damage.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Advanced Materials",
"Manufacturing technologies"
]
] |
W1570140883
|
Costo de producción de la cosecha de mango variedad tommy y kent en la empresa naturista S.A. división agrícola-hacienda la Chola, cantón Guayaquil, periodo 2013 - 2014. Quevedo
|
This information Draft Proposal Practice Exam Complexivo (PROPEC) necessary for obtaining Engineering degree in Accounting and auditing requirements, focuses on COST OF PRODUCTION OF THE HARVEST OF MANGO VARIETY TOMMY AND KENT IN THE COMPANY NATURISA SA DIVISION AGRICOLA-HACIENDA LA CHOLA, CANTON GUAYAQUIL, PERIOD 2013 - 2014, which allowed to know the real cost of producing a box handle.
The Draft Proposal Practice Exam Complexivo (PROPEC) covers all key modules to the cost of production as crop inputs, crop materials and supplies, wages of production, supply personnel, machinery and equipment, fuels and lubricants, basic services, materials and supplies and miscellaneous.
The costs related to crop production period Draft 2013 - 2014, using as a reference to the management of direct and indirect costs to obtain a desired end result gai
|
publication
|
[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas"
]
] |
W2280980473
|
Territorial Impact of EU Research & Development Policy
|
The project analyses the distribution of the two principal instruments of EU R&D policy: the Structural Funds and the RTD Framework Programmes.
The emerging picture of the EU's R&D geography is more complex than a simple core-periphery analysis would suggest. The spatial patterns of EU R&D policy expenditures are not evenly distributed. EU R&D policies are demonstrably impacting on the spatial geography of R&D across the EU in a number of ways. Chief amongst these are the effects of making connections between firms and research bodies across the EU and the strengthening of the capacity of individual regions to participate in research and innovation activities.
The effects of EU R&D policies are most strongly visible at the micro-scale. Within individual regions the Structural Funds are having important effects on supporting the development of research and innovation capacity.
On first sight the distribution of projects funded by the Framework Programmes appears to counteract territorial cohesion objectives, as economically stronger regions tend to have a larger number of firms and research organisations engaged in Framework Programme activities. However, closer analysis demonstrates that when economic strength is controlled for, and more particularly levels of R&D expenditure, many less favoured regions benefit disproportionately from the Framework Programmes.
The project shows that at the EU level the Framework Programmes are having a significant influence on stimulating the development of a European Innovation System through promoting linkages between researchers and companies located across the Union. These networks are actively stimulating knowledge exchange and innovation within their membership, with positive effects reported in home regions. EU R&D policy is making a strong contribution to building both individual skills and experience and to 'raising the game' of individual companies and organisations. The potential that these transnational networks offer in terms of wider spillover effects within home regions is substantial. However, current evidence suggests that the effects of this are in practice more limited.
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project/regional
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Circular systems"
]
] |
interreg_2909
|
Promotion of vine-growing and wine-making in the Lison Pramaggiore area and in the Slovenian territory
|
This project aims at promoting the wine sector in the Lison-Pramaggiore area and in the suitable areas of Slovenia, through a series of actions aimed at enhancing the most valuable types of production. With a view to the integration between the Italian market (in particular the Venetian market) and the Slovenian one, all the proposed activities aim at having a bearing on Slovenia by setting up relationships with local producers and operators and by distributing the information material. Several promotional-dissemination events have been organized, such as the project-opening conference in Dobrovo, which was attended by many Slovenian wine producers, and the tasting evening in Brda, with the cross-border comparative assessment of Lison Pramaggiore and Slovenian wines. In order to ensure a more relevant presence in the territory, five wine-tasting evenings have been organized in the province of Venice (in particular the areas of Chioggia, the Eastern Veneto and San Dona di Piave). Finally, during the 57th Pramaggiore National Wine Exhibition, the competition “Prodotti tipici transfrontalieri a confronto” ( “Cross-border typical products: a comparison”) was held. During this two-day exhibition, the public tasted six cross-border typical dishes and the wines produced in the area.
|
project/regional
|
[
[
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Social and economic transformations",
"Culture, cultural heritage and creativity"
]
] |
interreg_2883
|
Review of the state-of-the-art of exhaust particulate filter technology in internal combustion engines
|
The increasingly stringent emission regulations, such as US 2010, Tier 2 Bin 5 and beyond, off-road Tier 4 final, and Euro V/5 for particulate matter (PM) reduction applications, will mandate the use of the diesel particulate filters (DPFs) technology, which is proven to be the only way that can effectively control the particulate emissions. This paper covers a comprehensive overview of the state-of-the-art DPF technologies, including the advanced filter substrate materials, the novel catalyst formulations, the highly sophisticated regeneration control strategies, the DPF uncontrolled regenerations and their control methodologies, the DPF soot loading prediction, and the soot sensor for the PM on-board diagnostics (OBD) legislations. Furthermore, the progress of the highly optimized hybrid approaches, which involves the integration of diesel oxidation catalyst (DOC) + (DPF, NOx reduction catalyst), the selective catalytic reduction (SCR) catalyst coated on DPF, as well as DPF in the high-pressure exhaust gas recirculation (EGR) loop systems, is well discussed. Besides, the impacts of the quality of fuel and lubricant on the DPF performance and the maintenance and retrofit of DPF are fully elaborated. Meanwhile, the high efficiency gasoline particulate filter (GPF) technology is being required to effectively reduce the PM and particulate number (PN) emissions from the gasoline direct injection (GDI) engines to comply with the future increasingly stricter emissions regulations.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Clean, safe and accessible transport and mobility",
"Energy supply",
"Industrial competitiveness in transport"
]
] |
W2089417388
|
Cost Analysis of Medical versus Surgical Management of Glaucoma in Nigeria.
|
To analyze the cost of glaucoma medical therapy and compare it with that of surgical management in Nigeria.The cost of glaucoma drugs and that of surgical therapy in patients who attended the eye clinic of the University of Benin Teaching Hospital, Benin City, Nigeria, between December 2002 and November 2008 were calculated over a 3 year period of follow-up. Costs of medical and surgical therapy were compared based on November 2008 estimates.One hundred and eight patients met the inclusion criteria of the study, of which, 90 patients (83.33%) received medical therapy and 18 patients (16.67%) underwent surgery. The most expensive drugs were the prostaglandin analogues, travoprost (Travatan) and latanoprost (Xalatan). The least expensive topical drugs were beta-blockers and miotics. The mean annual cost of medical treatment was US$ 273.47±174.42 (range, $41.54 to $729.23) while the mean annual cost of surgical treatment was US$ 283.78±202.95 (range, $61.33 to $592.63). There was no significant difference between the mean costs of medical and surgical therapy over the 3-year period (P = 0.37). Older age (P = 0.02) and advanced glaucoma (P < 0.001) were associated with higher costs of therapy.The cost of medical therapy was comparable to that of surgical therapy for glaucoma in Nigeria over a 3-year period.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems"
]
] |
W1952100173
|
Stanton's “Solitude of Self” as Public Confession
|
Elizabeth Cady Stanton opened her now famous “Solitude of Self” by asserting her desire to make manifest the “individuality of each human soul.” Using Stanton's attempt to display the human soul as a case study, I consider in this essay the capacities of language to disclose the self. I argue that, for Stanton, self-disclosure is fundamentally performative: The “Solitude of Self” evokes the “inner-being we call ourself” through a reliance on, and a subsequent violation of, a distinctively narrative logic. As this violation takes from the audience the sense of order that the narrative had theretofore provided, it puts the audience in a position where they, now shorn of narrative and the order it provided, can experience firsthand the solitude of self.
|
publication
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
W2067374262
|
Postural networks: linking cognitive and motor control across the lifespan
|
Almost every movement we make requires the coordination of multiple muscles. How the central nervous system coordinates these patterns of muscle activity remains largely unknown. Here I propose muscle networks as an innovative and principled approach towards neural interactions underlying coordinated movements and posture to address this outstanding problem. Recent findings show robust patterns of neural coupling across multiple muscles. Application of network theory has brought about a paradigm change in brain research and has been crucial for understanding how neurons and neuronal structures connect and communicate. Here I will extend the approach used to study brain networks to the neuromuscular system and investigate the neural interactions within the brain and spinal cord involved in postural control using network analysis of brain and muscle activity (EEG & EMG). By relating network structure to postural kinematics obtained using 3D motion-capture technology, I will investigate the functional role of postural networks in healthy participants performing postural tasks and to map changes in postural control across the lifespan. Cognitive control and sensorimotor functions will be assessed using standardized test and correlated with network metrics to explain variability in postural control and disentangle their role in organizing of postural networks. By combining advanced computational analyses with state-of-the-art recording techniques, the project will enable reconstructing functional interactions in the distributed motor system from non-invasive recordings. Postural networks hence offer a promising new perspective on a long-standing open question in movement neuroscience. The expertise of my supervisors and the excellent facilities at Maastricht University provide an ideal environment in which to conduct this project and establish my own research group at a leading research institute in Europe.
|
project/european
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics",
"Emerging enabling technologies",
"Advanced computing and big data"
]
] |
3730461
|
From Karl Menger to Charles Menger? How Austrian economics (hardly) spread in France
|
The father of the “Austrian” Marginalist revolution and founder of the so-called “Austrian School of economics”, Carl Menger, had a mixed reception during different periods of development of French economics. Somewhat welcomed in the early days, he was rather forgotten later on. Even his major works were not published in translation until recently. What is the reason for such a situation? Criticisms of classical political economy have to be understood in their French context. In comparison to other countries, this paper details the case of France, besides showing how later Austrians, such as Friedrich Hayek, found a limited audience. This comparative study of economic ideas in France must start with the reception of the views of the founder and the role and impact of adopting/adapting or rejecting his views by French scholars. What place did they find in French academia? From Carl Menger to a “Frenchified” Charles Menger, how was Austrian economic thought disseminated in France? This essay starts by recalling the Belle-Époque and an astonishing letter by Charles Rist for the Jubiläum of Menger, in which he deplored the lack of translation of the latter’s works. The Austrian School in France is then discussed as pure economics replaces political economy in the Interwar period, with the 1938 Paris Congress of “liberal thinkers,” as the Vienna Circle became known, also comparing issues in philosophy. The paper considers how Austrian theories of “pure science” were received in Paris from the Vienna of the 1900s, at a time of ”Crossroads,” to the present day, through the Postwar and Cold War, until a revival since the 1990s and a rethinking of economic ideas after 2008.
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publication
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[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Social and economic transformations",
"Culture, cultural heritage and creativity"
]
] |
W2799947398
|
The influence of TQM practices on supply chain collaboration: a proposed model for the service industry
|
This study proposes a research framework of Total Quality Management (TQM) practices towards the supply chain collaboration level. The proposed model is based on the extensive literature review; this study develops a model of TQM practices that influence the supply chain collaboration level. The findings from this study would provide a basis for developing an advanced model of TQM towards the supply chain collaboration level. The organisations that would like to implement supply chain collaboration will be able to make managerial decision based on the TQM practices from this research. This study also makes a significant contribution by developing a model of TQM and supply chain collaboration in service industry. Furthermore, the organisations could use this framework to conduct a pre-test baseline measurement and periodically assess the effect of TQM practices.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced computing and big data",
"Manufacturing technologies"
]
] |
W2107776596
|
IMPLEMENTASI KEBIJAKAN PAJAK AIT TANAH DI KOTA TEGAL (KAJIAN PERDA NOMOR 2 TAHUN 2011 TENTANG PAJAK AIR TANAH)
|
Groundwater tax is one type that is managed by the local tax . Tax groundwater previously managed by the provincial government then managed entirely by local governments as a form of decentralization . Implementation of tax policy at Tegal ground water is fully regulated in Regulation No. 2 of 2011 About Tax Groundwater . Authorized agency in terms of tax collection and management of ground water is Revenue Service, Management, Finance and Public Asset ( DPPKAD). Local regulations governing the issuance of tax policy groundwater is one of the efforts to preserve and control of groundwater use , so that it can be used on an ongoing basis and the tax function as a source of income to finance a useful area for regional development. This study aims to explain how tax policy implementation groundwater management in Tegal and identify aspects that support and hinder the implementation of tax policy groundwater managed by DPPKAD Tegal and is expected to become an input for implementing this policy. Supporting and inhibiting aspects identified aspects of the phenomenon of financial resources, economic conditions, social and political society, communication, and characteristics of the implementing agency. This is a descriptive qualitative study, using snowballing sampling technique. This study shows that the implementation of the groundwater tax already well proven with the successful achievement of the groundwater tax revenue , but there are some obstacles in its implementation. Many inhibiting factors that affect the implementation of groundwater tax collection, there are limited budget, yet comprehensive level of consciousness by taxpayer, and the lack of participation of the taxpayer and lack of socialization because DPPKAD has never held a formal socialization.
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publication
|
[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Net-zero and less polluting Industries",
"Circular systems"
]
] |
W1908340172
|
Aggregation and improved governance for untapping residential energy efficiency potential in the basque country
|
Energy retrofitting of post-World War II private multifamily residential buildings has been identified as a great challenge across Europe. Lack of adequate investment schemes, misalignment between residents' needs and grants and loans' design, complex governance and management, and fragmented demand are hindering the great energy saving potential captured in this sector, especially in South Europe, where fragmented property structure and longer return periods in energy efficiency investments complicate reaching the necessary agreements to retrofit.
To tackle this complex challenge, AGREE aims at triggering investments in energy efficient retrofitting of private multifamily residential building estates through the development and deployment of innovative and replicable mechanisms for:
1) Demand activation and aggregation: based on an integrated approach to retrofitting that includes energy efficiency and other drivers such as improved habitability and accessibility, and benefitting from cost-effective energy retrofitting by aggregation of demand of similar building types, built at the same time and inhabited by similar populations.
2) Specific financing solution based on demand segmentation and tailored combination of grants and loans through the activation of a specific Retrofitting Fund led by the Basque Government in concertation with the private finance community, to reach traditionally excluded populations and unlock energy retrofitting in multi-ownership buildings.
3) Improved governance, ensuring residents, finance community and other relevant stakeholders' engagement along the process, as well as multilevel coordination to ensure effective policy design and implementation.
Led by the Basque Government, the AGREE consortium and relevant stakeholders will co-design and implement an innovative and replicable Deployment Package to retrofit multifamily building estates dating from 1940-80 in 3 pilot cases in the Basque Country, mobilizing an investment of about 8.5M€
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project/european
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Buildings and industrial facilities in energy transition",
"Communities and cities",
"Energy systems and grids"
]
] |
981361
|
Accroître la compétitivité de l’entreprise grâce à la mise en œuvre d’une technologie de traitement des détails géométriquement complexe
|
L’objet du projet est l’achat d’une fraiseuse CNC 5 axes. Le résultat de l’investissement sera la mise en œuvre de l’innovation de processus (usinage efficace et de haute précision en 5 axes), l’innovation produit (produits complexes géographiquement avec des tolérances dimensionnelles étroites), l’innovation marketing (nouveau positionnement des produits de l’entreprise pour augmenter les ventes). À la suite du projet, un nouveau lieu de travail sera créé. Le projet contribuera à renforcer la compétitivité du candidat et à réduire les effets négatifs de la pandémie de COVID-19.
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project/regional
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
Q4427533
|
Anesthesia Preoperative Clinic Referral for Elevated Hba1c Reduces Complication Rate in Diabetic Patients Undergoing Total Joint Arthroplasty
|
Diabetes mellitus (DM) is risk factor for complications after orthopedic surgery.We tested the hypothesis that anesthesia preoperative clinic (APC) referral for elevated glycosylated hemoglobin (HbA1c) reduces complication rate after total joint arthroplasty (TJA).Patients (n = 203) with and without DM were chosen from 1,237 patients undergoing TJA during 2006 - 12. Patients evaluated in the APC had surgery in 2006 - 8 regardless of HbA1c (uncontrolled). Those evaluated between in subsequent two-year intervals were referred to primary care for HbA1c ≥ 10% and ≥ 8%, respectively, to improve DM control before surgery. Complications and mortality were quantified postoperatively and at three, six, and twelve months. Length of stay (LOS) and patients requiring a prolonged LOS (> 5 days) were recorded.Patients (197 men, 6 women) underwent 71, 131, and 1 total hip, knee, and shoulder replacements, respectively. Patients undergoing TJA with uncontrolled HbA1c and those with HbA1c < 10%, but not those with HbA1c < 8%, had a higher incidence of coronary disease and hypercholesterolemia than patients without DM. An increase in complication rate was observed in DM patients with uncontrolled HbA1c versus patients without DM (P < 0.001); the complication rate progressively decreased with tighter HbA1c control. More DM patients with preoperative HbA1c that was uncontrolled or ≥ 10% required prolonged LOS versus those without DM (P < 0.001 and P = 0.0404, respectively).APC referral for elevated HbA1c reduces complication rate and the incidence of prolonged hospitalization during the first year after surgery in diabetics undergoing TJA.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems"
]
] |
W1600884130
|
Scalability of robot swarms when applied to maze solving
|
Swarm robotics offers an intriguing approach to many real-world engineering problems. Such tasks that require covering a large search space or that involve working in potentially hazardous environments naturally lend themselves to robotic and/or swarm solutions. This research examines the effect of changing swarm size on the performance of several different maze-solving algorithms, including random movement, obstacle avoidance, and wall-following algorithms. The choice of algorithms was limited to ones that (a) do not require direct bot-to-bot communication, (b) use bots with a limited sensing range and (c) do not require the bots to know their position. Two different robots were used in the experimental trials: the HEXBUG Larva and the e-puck mobile robot. Trials were conducted with two, four, eight, and (with the Larva) sixteen bots. Results are presented for each of the trials as well as discussion on swarm performance as related to swarm size and bot intelligence. The results show that a small swarm that is more sophisticated or intelligent can perform as well as a larger swarm made up of less intelligent bots.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics",
"Advanced computing and big data"
]
] |
W1500558033
|
New gravitational scales in cosmological surveys
|
In the quasistatic regime, generic modifications to gravity can give rise to novel scale-dependence of the gravitational field equations. Crucially, the detectability of the new scale-dependent terms hinges upon the existence of an effective mass scale or length scale at which corrections to General Relativity become relevant. Starting from only a few basic principles, we derive the general form of this scale-dependence. Our method recovers results previously known in the specific case of Horndeski gravity, but also shows that they are valid more generally, beyond the regime of scalar field theories. We forecast the constraints that upcoming experiments will place on the existence of a new fundamental mass scale or length scale in cosmology.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Climate science and solutions",
"Energy systems and grids"
]
] |
W2018909796
|
Smart big data platform to offer evidence-based personalised support for healthy and independent living at home
|
It is a fact that the European population growth is slowing down, while the population ageing accelerates. Rapid increases in the elderly population are predicted for the coming decades due to the ageing of post-war baby births. Within Europe’s ageing population, Hearing Loss, Cardio Vascular Diseases, Cognitive Impairments, Mental Health Issues and Balance Disorders, as well as Frailty, are prevalent conditions, with tremendous social and financial impact. Preventing, slowing the development of or dealing effectively with the effects of the above impairments can have a significant impact on the quality of life and lead to significant savings in the cost of healthcare services. Digital tools hold the promise for many health benefits that can enhance the independent living and well-being of the elderly.
Motivated by the above, the aim of the SMART BEAR platform is to integrate heterogeneous sensors, assistive medical and mobile devices to enable the continuous data collection from the everyday life of the elderly, which will be analysed to obtain the evidence needed in order to offer personalised interventions promoting their healthy and independent living. The platform can also be connected to hospitals and other health care service systems to obtain data of the end-users (e.g., medical history) to be considered in making decisions for interventions. SMART BEAR will leverage big data analytics and learning capabilities, allowing for large scale analysis of the above mentioned collected data, to generate the evidence required for making decisions about personalised interventions. Privacy-preserving and secure by design data handling capabilities, covering data at rest, in processing, and in transit, will cover comprehensively all the components and connections utilized by the SMART BEAR platform. The SMART BEAR solution will be validated through five large-scale pilots involving 5.100 elderly living at home in Greece, Italy, France, Spain, Portugal and Romania.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Health throughout the life course",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
2727430
|
Engineering disease resistance gene networks: synthetic helpers for expanded sensors
|
To resist pathogen colonisation, plants have evolved a number of complex defense mechanisms that are activated upon recognition of pathogen-secreted molecules. These include cell surface or intracellular immune receptors, through either direct or indirect binding. Nucleotide-binding leucine rich repeat proteins (NB-LRRs or NLR) make up the largest family of intracellular immune receptors. Some of these NLR proteins were shown to function in pairs, with “sensors” mediating pathogen recognition and “helpers” eliciting a resistance response. Preliminary data revealed that many Solanaceae NLR sensors are dependent on three NRC (NLR proteins required for HR associated cell death) helper proteins (NRC2, NRC3, NRC4) in a complex and redundant signalling network. These NLR sensors, and their homologs, confer resistance to a diverse number of Solanaceae pathogens, including bacteria, oomycete, viruses, nematodes and insects. This suggests that NLR helper proteins play a major role in mediating disease resistance against a range of plant pathogens that infect the Solanaceae family. My objective is to use this information to engineer synthetic NRC helper proteins with enhanced sensor specificities. This will potentially result in resistance effective against multiple pathogen species currently affecting Solanaceae crops. To achieve my objective, I will undertake functional analyses of helper-sensor pairs, and study their interaction with known pathogen effectors to generate both chimeric and mutant NRC proteins with novel properties. I will then assess these candidate NRC proteins for enhanced disease resistance using a variety of genetic complementation assays. At the completion of this project I will deliver synthetic NRC helper proteins that confer expanded disease resistance in Solanaceae crops.
|
project/european
|
[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Emerging enabling technologies",
"Advanced Materials"
]
] |
184448
|
Ubiqutekglide: an advanced electrical weed control device to be integrated with existing agricultural equipment, yielding a zero chemical, organic result at a reduced operational cost
|
Reduce herbicide usage. Ubiqutek, a UK-based SME built on over 45 years of research presents ‘Glide’ a cost-effective, safe to use and environmentally friendly electrical agricultural weed control solution to be integrated to existing manufacturer’s agricultural platforms.
Benefiting the agricultural market, Glide successfully controls weeds, whilst reducing operational costs and the industries use of herbicides and replacing with an organic process that maintains soil moisture and nutrients and increases crop yield.
Having already developed ‘Touch', a horticultural and amenity electronic weed control device that has been well received by the market, we are well placed to adapt our core technology for the agricultural market. During our Phase 1 feasibility study, we have undertaken significant research to prove commercial and technical feasibility including voice of customer and business planning, and are now embarking on our Phase 2 journey. We have an ambitious growth target to achieve revenue of €37.5m pa by 2023, cumulative net profit of €49.6m, and creating direct employment of 14 FTE. We project the ROI to the EC at 4.8 with breakeven at year 4 post-commercialisation.
Weeds are controlled largely for food production due to their economic significance: the biotic stresses caused by weeds, insects and diseases cause a 31–42% loss in annual food production globally (€454bn). Herbicides account for over a third of the pesticides used in Europe; without herbicides, it is predicted food prices would increase by 40%
With herbicides being legislated against due concerns over their health effects, and given increasing global food requirements, alternative weed control technology is essential in the prevention of unsustainable food inflation. This Horizon 2020 Phase 2 project will allow us to scale up our existing prototype and gain independent and extensive trial results of the Glide technology enabling us to launch to market with the necessary evidence of efficacy
|
project/european
|
[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Net-zero and less polluting Industries",
"Emerging enabling technologies",
"Circular systems",
"Manufacturing technologies"
]
] |
216009
|
INCREASE COMPETITIVENESS SMES — ECO CENTER SARDEGNA S.R.L.
|
THE INITIATIVE IS AIMED AT INCREASING THE PRODUCTION CAPACITY OF THE COMPANY’S PLANT THROUGH THE REDEVELOPMENT OF THE EXISTING UNCOVERED AREA FOR THE CREATION OF NEW OPEN-AIR SPACES FOR THE RESERVOIR OF WASTE BY MEANS OF MASONRY WORKS, THE PURCHASE OF A PLANT FOR THE PACKAGING OF THE DRY FRACTION OF MUNICIPAL AND INDUSTRIAL WASTE, OF A TRAILER, OF COMPACTERS AND VARIOUS EQUIPMENT.
|
project/regional
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Circular systems",
"Manufacturing technologies"
]
] |
Q4753821
|
Optimal feed profile for the Rhamnolipid kinetic models by using Tabu search: metabolic view point
|
Rhamnolipids are bio surfactants which are extra-cellular glycolipids composed of L-rhamnose and 3-hydroxyalkanoics. Rhamnolipids are produced through fermentation process by using Pseudomonas sp. as the species. An alteration to the traditional procedures in order to achieve increase in the production of biosurfactants, a numerous process technologies have been adopted in fed batch mode. Fed batch mode facilitates the high production of product by avoiding the substrate or product inhibition line of attack. To overcome the controlling parameters which reduce the product yield, optimal control profiles are designed. In order to develop viable control methods for fed-batch fermentation of Rhamnolipid production, multiple substrate feeding strategies were employed and their efficiencies were compared with different substrates concentration of glucose, nitrogen and phosphorous. The product formation depends upon the substrate feeding strategy and so, the fed-batch fermentation was carried out by using P. aeruginosa providing substrates at manifold rates. With the obtained experimental data, using the kinetic models (logistic equation and by Luedeking Piret), the kinetic parameters were estimated. These kinetic parameters were implemented in tabu search algorithm and this programme was executed in Dev-C++, optimal control profiles were generated as a result. These obtained optimal control profiles have shown an increase in productivity of rhamnolipid with a decline in computational time. Through this procedure, the optimal control profiles of substrate feeding strategies of glucose, nitrogen and phosphorous were estimated. In comparison with other algorithms like genetic algorithm, Tabu Search algorithm was able to generate an accurate optimal control profiles with a reduction in their intricacy.
|
publication
|
[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Artificial intelligence and robotics",
"Advanced Materials",
"Manufacturing technologies",
"Advanced computing and big data"
]
] |
W2556388764
|
Disrupting a socio-ecological system: How could traditional ecological knowledge be the key to preserving the Araucaria Forest in Brazil under climate change?
|
Abstract Socio-ecological systems (SESs) hinge on human groups and ecosystems, promoting interdependence and resilience to environmental disturbances. Climate change effects propagate from organisms to biomes, likely influencing SESs. In southern Brazil, the Araucaria Forest is a typical SES due to the historical interaction between humans and biodiversity. Thus, we empirically and theoretically evaluated how climate change could disrupt this system by interviewing 97 smallholders and assessing their traditional ecological knowledge (TEK). We evaluated and measured the socioeconomic impact of the araucaria’s ( Araucaria angustifolia ) nut-like seed (pinhão) trade and the ethnoecological knowledge about climate change, as well as generated an ecosystem services network. We used these empirical data with a projected loss of 50–70% of the Araucaria Forest due to climate change to quantify the risks of the potential disruption of this SES. We found evidence that to avoid the disruption of the Araucaria Forests, it is paramount to value TEK holders, safeguard the historical socio-ecological interaction, and promote non-mutually exclusive measures in an integrative response to maintain the resilience of this forest to future disturbances.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Climate science and solutions",
"Communities and cities"
]
] |
W4281789625
|
ROADWAY ON BRIDGES COMPRISING A CONCRETE BRIDGE-SUPPORTING STRUCTURE
|
Disclosed is a roadway structure on bridges comprising a concrete bridge-supporting structure (1). The surface of the roadway structure is provided with an elastic plastic seal (2). An adhesive layer (3) is applied to the plastic seal (2), and a concrete roadway (4) is applied to the adhesive layer (3), thus forming a permanent bond between the bridge-supporting structure (1), the plastic seal (2), the adhesive layer (3), and the concrete roadway (4).
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
AT 2008000039 W
|
Feeding ecology of the topmouth gudgeon pseudorasbora parva (Temminck and Schlegel, 1846) in the Gelingüllü Reservoir, Turkey
|
Pseudorasbora parva (Temminck and Schlegel, 1846) is widely distributed in rivers and lakes of Turkey owing to accidental introductions. Turkey is rich in biodiversity of freshwater fish and has a high level of endemicity of native ichthyofauna, which is vulnerable to such introductions. The Gelingullu Reservoir located on the Kizilirmak drainage in Central Anatolia has rich ichthyofauna with native and introduced fish species, including endemic species. The contents of the foregut of P. parva samples collected between Summer 2003 and Summer 2005 were examined. Seasonal and ontogenetic changes in feeding intensity were determined. P. parva mainly feeds on zooplankton such as Cladocera, Copepoda, and Rotifera. Members of the Bacillariophyta and Cyanobacteria were identified in high proportions in the foregut contents of P. parva particularly during summer. The feeding traits of this invasive fish may have an influence on the establishment of a successful population in Gelingullu reservoir.
|
publication
|
[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Seas, oceans and inland waters",
"Biodiversity and natural resources",
"Environmental observation"
]
] |
W1562725479
|
A study of the prevalence of diarrhoeagenic Escherichia coli in children from Gwagwalada, Federal Capital Territory, Nigeria
|
Diarrhoeagenic Escherichia coli (DEC) are major causes of diarrhoea in Nigeria. This study was conducted to determine the prevalence of diarrhoea caused by DEC within the Federal Capital Territory, Abuja, Nigeria.A total of 730 rectal swabs obtained from 201 children with diarrhoea and 529 healthy controls aged 0-24 months were cultured for the isolation of Escherichia coli. All E. coli isolates were investigated by PCR to determine their pathotype.A total of 61 DEC strains were recovered at a rate of 18.4% and 2.6% from children with diarrhoea and healthy controls respectively. The DEC strains recovered were Enteroaggregative Escherichia coli (34.4%), Shiga-toxin producing Escherichia coli (31.1%), Enterotoxigenic Escherichia coli(18.0%), typical enteropathogenic Escherichia coli (15.0%) and Enteroinvasive Escherichia coli (1.6%). Shiga-toxin producing Escherichia coli andEnteroinvasive Escherichia coli were recovered only from children suffering from diarrhoea and the overall prevalence of DEC strains was significantly higher among the children with diarrhoea (P < 0.0001). The number of DEC strains obtained during the dry season was significantly higher (P = 0.012) than the number obtained in the rainy season.Diarrhoea caused by E. coli in the Nigerian children studied is associated with several diarrhoeagenic pathotypes and a significant proportion of the healthy children were found to harbour EAEC and ETEC strains. These asymptomatic carriers may be regarded as potential transmitters of infection to vulnerable children in the study area.
|
publication
|
[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Environmental and social health determinants",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W2069673968
|
Development of interdisciplinary assessment for manufacturing and design
|
DIAS develop and demonstrate the integrated multidisciplinary tools necessary to speed up implantation and design integration or Open Rotor structural components in next generation aircrafts. This require more flexible design studies, allowing a wider set of design variants to be explored simultaneously with accounting for manufacturing equipment and process applicability.
DIAS bring in state of the art modelling and simulation techniques for robot path assessment, geometrical variation of weld assembly using advanced modelling software and combines these with architectural modelling tools (CCM, CAM) that allow impact assessment on system level, risk and cost to be included in the same study
The studies are conduced as evolving and digital design of experiments first outlining the desired design space, identifying feasible regimes of the design space and generate variations of geometries and manufacturing technologies. The results from the simulations are used together with already existing data from Clean Sky high fidelity simulations and experiments to form validated surrogate models. Decision makers and specialist from multiple domains team up and conduct real time trade off analyses to identify most resilient design. AI and Machine learning algorithms are used to facilitate intelligent and interactive decision support.
The consortia of Chalmers, Cambridge and FCC have experience form collaborating both with the topic leader and eachother from several preceeding research projects and bring together extensive expertise and experience into the study. The expected outcome is expected to allow the manufacturer to optimize new design and reduce the risk to introduce Clean Sky demonstrated configurations and technologies to be introduced in next generation products. As such, DIAS have a profound impact on realizing the significant potential demonstrated for Open Rotor architectures, while including competitive assessment and risk reducing design capabilities.
|
project/european
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics",
"Emerging enabling technologies",
"Key digital technologies",
"Circular systems",
"Advanced Materials",
"Manufacturing technologies",
"Advanced computing and big data",
"Next generation internet"
]
] |
3733913
|
Non stain flooring
|
A flooring material (1) comprises a base portion (2) having a coating portion (3) which imparts improved stain resistance to the flooring material (1) and is positioned in contact with an upper surface of the base portion (2). The coating portion (3) creates an upper surface of the flooring material (1). A particulate material (6) is embedded in the coating material (3) and at least partially penetrates the base portion (2). The particulate material (6) provides a roughened effect to the upper surface of the flooring material (1) and protects the coating from wear. The coating (3) merges into the base portion (2) where they meet at joint (4) to form a stratified portion (5).
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
GB 0117089 A
|
The Loss of Intangible Assets and the Construction of Evasion Mechanism in Market-Oriented Operation of Sports Events——In the case of The National Games
|
This paper gives the definition and attribution of intangible assets of sports events preliminarily and elaborates the forming process of intangible assets of sports events through analysis of the literature and experts interviews.Based on the process of formation and realization of the value and in the case of the National Games,the performance of the loss intangible assets of sporting events in China,including Acquired Loss 、 Basic Loss , Protection Loss and Guarantee Loss .On the basis of analysis of experts interviews,the objective factors of loss of intangible assets of the National Games are that the intangibility , accumulation and specialty of intangible assets of sporting events and the duality of National Games lead to the pricing problem.The subjective factors of loss of intangible assets of the National Games are administrative dependence,unclear positioning and lack of market development capacity.On this basis,the construction of evasion mechanism of loss of intangible assets : improving the core value system and building brand identity system to circumvent acquired loss;enhancing the credibility of sports events to circumvent basic loss;improving the protection and development system of intellectual property rights to circumvent protection loss;guaranteeing the interests of intangible assets ’ consumers to circumvent guarantee loss.
|
publication
|
[
[]
] |
[
[]
] |
W2349008461
|
Role of shear-thinning on the dynamics of rinsing flow by an impinging jet
|
Using a jet of one fluid to ablate a second liquid that coats a planar substrate produces a variety of interesting flow structures. These rinsing flows can create alternating layers of jet and coating fluids, creating difficulties in imaging the resulting radial hydraulic jumps for qualitative and quantitative data extraction. This study is an extension of the work done by Hsu et al. [“Role of fluid elasticity on the dynamics of rinsing flow by an impinging jet,” Phys. Fluids. 23, 033101 (2011)10.1063/1.3567215] and presents a method to reveal the positions of the free surfaces in rinsing flows as well as exploring the role of shear thinning in this flow process. Following the previous work, we used an impinging jet of water to rinse coating fluids of varying rheologies to understand the flow structures during the transient growth of the resulting hydraulic jumps, observing rheological dependencies on the jump magnitude and velocity and overall topography. While many instabilities have been shown to arise...
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
W2061566406
|
VEHICLE AUTOMATIC EMERGENCY RESPONSE SYSTEM
|
An automatic emergency response system (12) is operable to notify an emergency centre (27) of a defined event, such as a vehicle accident. The system facilitates location of the event, by using position determining means, such as GSP (18), to establish its at least approximate location. A control circuit (19) includes code generating means to generate a coded signal incorporating the position location information. An alarm signal transmitter (16) is operable on occurrence of the defined event to transmit an alarm signal incorporating the coded signal to a receiving station (26), which may be a satellite, which relays the message to the emergency centre (27), including the positional information relating to the location of the transmitter (16). A relative low power homing signal transmitter (17) simultaneously transmits a homing signal either continuously or at periodic intervals.
|
patent
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Key digital technologies"
]
] |
AU 1916/003003 W
|
Voltage control of PV-Rich LV networks: OLTC-fitted transformer and capacitor banks
|
Due to the increasing adoption of domestic photovoltaic (PV) systems, the use of technologies such as on-load tap changer (OLTC)-fitted transformers, capacitor banks, and remote monitoring are being considered to mitigate voltage issues, particularly in European-style low voltage (LV) networks. Depending on the control strategy, however, the effects on customer voltages and control actions (e.g., tap changes or capacitor switching) can vary significantly. This work presents a framework to assess the performance of different OLTC-based control strategies in terms of voltage compliance with the standard BS EN50160 and the number of control actions. Three control strategies are proposed: constant set-point (CSC), time-based (TBC) and remote monitoring-based (RMC). A week-long Monte Carlo analysis is carried out considering a real UK LV network, three-phase power flows, different PV penetrations and seasonality. Results show that the TBC outperforms the CSC but at the expense of more tap changes. Due to the enhanced visibility, the RMC significantly increases the PV hosting capacity whilst limiting tap operations. Finally, when feeders have contrasting voltage issues, capacitor banks are found to provide additional flexibility and allow higher PV penetrations. These findings are expected to help the industry determining the benefits from OLTC-based solutions in future LV networks.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Energy supply",
"Energy systems and grids"
]
] |
W2603139913
|
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