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EFFECT OF END POINT TEMPERATURE ON COOKING LOSSES, SHEAR FORCE, COLOR, PROTEIN SOLUBILITY AND MICROSTRUCTURE OF GOAT MEAT
|
The effect of end point cooking temperature on quality of goat semimembranosus muscle was evaluated. The semimembranosus muscles were removed from 15 goat legs, cut into strips (4.0 cm × 4.0 cm × 5.0 cm) and vacuum packaged. Vacuum-packed strips were heated to one of nine end point temperatures: raw, 50, 55, 60, 65, 70, 75, 80, 85 and 90C. Cooking losses (CLs), shear force (SF), color, protein solubility and microstructure of strips were determined. Increasing end point temperature to more than 60C led to a significant increase in CL. SF showed a four-phase change as a result of increasing end point temperature from raw to 90C. The redness a* decreased significantly (P < 0.05) during the range of 50–80C. The collagen solubility significantly increased with increasing temperature up to 55C. The sarcoplasmic protein solubility decreased significantly (P < 0.01), while the myofibrillar protein solubility only increased a little with increasing temperature between 55 and 90C.
PRACTICAL APPLICATIONS
Cooking temperature has great influence on meat textural and eating qualities. This investigation measures the effects of end point cooking temperature on CLs, SF, color, protein solubility and microstructure of goat meat. The results are beneficial in terms of providing evidence of the trend and thus allow the industries and consumers to choose the best cooking temperature during processing of goat meat.
|
publication
|
[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas",
"Food systems"
]
] |
W1883996186
|
An avant-garde measuring principle based on the potentiometric method using signals from the kidney to monitor hospitalised patients water-volemic state
|
The need of high quality and cost-efficient hemodynamic and metabolic state monitoring devices is increasing exponentially, due to e.g. ageing population, chronic health conditions, health support system advance in developing courtiers and rural areas and the growing number of cases of chronic conditions in Europe and worldwide.
Existing monitoring technologies are either very basic (e.g. ECG and heart rate), energy consuming or are difficult in use and installation among many other drawbacks. Several research studies suggest using alternative urinary ammonium measurements (e.g. 24-hours analysis). But urine anion and osmolar gaps connected to this type of analysis are not accurate enough to be reliable surrogate measures, since this method requires sample treatment.
KARDIA a company founded in 1995 in Milan, developed a monitoring device that doesn’t require sample treatment, is non-invasive, low cost, low energy consuming and it is easy to use, install, move, handle: K.IN.G.- Kidney INstantaneous monitorinG.
K.IN.G. aims to reduce morbidity and mortality rates among patients and to optimize therapeutic strategies by providing a cost-effective innovative and non-invasive monitoring solution. The solution also simplifies work of medical staff as it is portable and easy to use. K.IN.G. offers strong environmental advantages, as it diminish the energy consumption by 50%. It. also has the potential to boost the growth of KARDIA, reaching unprecedented sales parameters leading to the creation of new jobs and to contribute to KARIDA’s mission to ensure gender balance by recruiting female staff.
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project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Health throughout the life course",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
895957
|
Phase diagram of Ge:(C, Sn)
|
Abstract We present the self-assembling conditions of 1C4Sn tetrahedral nanoclusters with carbon atoms in their centers in Ge:(C, Sn) in the wide temperature range as a function of the impurity contents and temperature. These conditions are the phase diagram of Ge:(C, Sn) since nanocluster occurrence and completion of self-assembling when all carbon atoms are in nanoclusters are results of the continuous phase transitions. The significant decrease of the strain energy after formation of nanoclusters is a cause of self-assembling. It is shown that the nanocluster occurrence temperature depends only on the Sn content. The impurity content conditions when all carbon atoms are in 1C4Sn nanoclusters are obtained for the temperatures up to 855 ∘ C.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials"
]
] |
W2052610281
|
Lithography process simulation studies using coarse-grained polymer models
|
Lithography processes were modeled on the basis of coarse-grained polymer simulation techniques using OCTA, which is the simulation software for soft materials, and the simulations of these processes were performed to clarify the mechanism of the polymer chain dynamics in lithography processes. In the case of the top-down process, the development and rinse processes were modeled using a dissipative particle dynamics method. From our series of simulations, the line pattern constituted by resist polymers can be simulated as a result. In the rinse process, the reduction of line edge roughness (LER) can be found, and the importance of the rinse process to modify the LER was identified. The bottom-up process, which is called the directed self-assembly (DSA) process, can also be simulated. From our DSA process simulations, the polymer chain dynamics in the defect annihilation process can be analyzed. The lithography process simulations modeled by coarse-grained polymer techniques are reviewed. As a case of top-down process, development and rinse processes were simulated. From these simulations, line edge structure can be obtained to discuss the line edge roughness. As a case of bottom-up process, the directed self-assembly (DSA) process was simulated, and the polymer chain dynamics in the defect annihilation process can be analyzed.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
W2401031876
|
CNC stroj za graviranje - konstrukcija mobilne izvedbe stroja za obradu granita
|
Although the hand-engraving granite and granite blasting is still very much present, appeared
in the modern world the need for faster and more precise production of engravings and
inscriptions on granite surfaces. The big problem appears in situations when we try to make
engravings and inscriptions directly on granite monuments or granite slabs of large dimensions
which can not be set as the workpiece on the machine tool. Also, engraving machines and
machines that produce images one can find today on the market are dependent on electricity
(must be connected to the grid or generator).
For all these reasons, mobile engraving granite machine will come to the fore. It will shorten
the time of production, increase productivity, and also we do not need electricity connected to
cable, but we have a battery with which we can work a few hours.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
W2592686610
|
Preparing the creation of bio-based education centres to meet industry needs and boost the contribution of the bioeconomy to societal challenges
|
Unlocking the full potential of the bioeconomy and its value chains requires a systematic and collaborative perspective for) the development of new skills, educational approaches and organisational solutions to provide education and training services.
The aim of the BIObec project is to develop a holistic framework for multi-level Bio-Based Education Centers (BBEC) flexible enough to answer the present and future needs of the industry and of the surrounding ecosystem at local, regional, national and/or international levels.
The project will design 6 BBEC pilots assuring a wide geographical coverage in Europe and addressing different topics linked to the variety of value chains and institutional contexts (vocational to university level, primary producers, processors, SMEs to MNCs).
BIOBEC will clarify the needs of the different regional ecosystems and will provide detailed design, economic and financial assessment, governance plans for the educational training centres, as well as plans for life-long-learning programmes. It will also develop collaborative tools to maximize the synergies between them at the European and international level.
The project will mobilise a network of 19 partners, which are leaders in Bioeconomy Education from different perspectives (ranging from academia to industry) together with a wide network of Implementation and Replication Working Groups and local stakeholders based in the EU. This network will pave the way for implementation and replication of the BBEC, in order to boost the contribution of the education sector for the development of the bioeconomy.
|
project/european
|
[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Circular systems",
"Bio-based innovation systems in the bioeconomy"
]
] |
643589
|
Advanced mechatronics devices for a novel turboprop electric starter-generator and health monitoring system
|
The ACHIEVE Consortium will bring together their world-leading expertise in the design and manufacturing of electrical machines for aircraft Advanced Generation Systems (AGS), integrated Power Electronics (PE), advanced control systems and intelligent thermal management, to develop an innovative advanced mechatronic device for electrical power management system of Turboprop.
The ACHIEVE Consortium will combine their world-leading expertise in the technical areas of PE, AGS and their control, as well as in modelling and simulation for aerospace applications. The aim of ACHIEVE is to develop an innovative mechatronic system with functions of generating, multi-functional, more efficient, reliable, compact and lighter and hence contributing towards higher performance and more efficient and greener turboprops
The topic of advanced mechatronics devices is to support the CS2 Engine ITD WP3 “Business aviation / Short range reginal Turboprop Demonstrator” programme led by Turbomeca. The WP3 aims to acquisition of technologies for a high performance turboprop engine in the 1800-2000 shp class for business aviation and short range regional applications. This project will deliver a novel advanced mechatronics device which will be integrated to the developed engine. The developed mechatronic device is essentially an electrical starter/generator system with functions including motoring, generating, power transmission, health monitoring and communication.
The concept of ACHIEVE is to design, manufacture and test an innovative and integrated mechatronic device which is capable of performing motoring, generating, power transmission, health monitoring and signal communications. The mechatronic device is essentially made of an electrical machine, an electronic power converter and associate controllers. Moving from the state-of-the-art brushed 28Vdc generator, the system developed within the ACHIEVE will be brushless with higher power density, lower weight and higher TBMO.
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project/european
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Net-zero and less polluting Industries",
"Key digital technologies",
"Advanced Materials",
"Manufacturing technologies"
]
] |
217474
|
Role of penA polymorphisms for penicillin susceptibility in Neisseria lactamica and Neisseria meningitidis
|
In meningococci, reduced penicillin susceptibility is associated with five specific mutations in the transpeptidase region of penicillin binding protein 2 (PBP2). We showed that the same set of mutations was present in 64 of 123 Neisseria lactamica strains obtained from a carriage study (MIC range: 0.125-2.0mg/L). The PBP2 encoding penA alleles in these strains were genetically similar to those found in intermediate resistant meningococci suggesting frequent interspecies genetic exchange. Fifty-six N. lactamica isolates with mostly lower penicillin MICs (range: 0.064-0.38mg/L) exhibited only three of the five mutations. The corresponding penA alleles were unique to N. lactamica and formed a distinct genetic clade. PenA alleles with no mutations on the other hand were unique to meningococci. Under penicillin selective pressure, genetic transformation of N. lactamica penA alleles in meningococci was only possible for alleles encoding five mutations, but not for those encoding three mutations; the transfer resulted in MICs comparable to those of meningococci harboring penA alleles that encoded PBP2 with five mutations, but considerably lower than those of the corresponding N. lactamica donor strains. Due to a transformation barrier the complete N. lactamica penA could not be transformed into N. meningitidis. In summary, penicillin MICs in N. lactamica were associated with the number of mutations in the transpeptidase region of PBP2. Evidence for interspecific genetic transfer was only observed for penA alleles associated with higher MICs, suggesting that alleles encoding only three mutations in the transpeptidase region are biologically not effective in N. meningitidis. Factors other than PBP2 seem to be responsible for the high levels of penicillin resistance in N. lactamica. A reduction of penicillin susceptibility in N. meningitidis by horizontal gene transfer from N. lactamica is unlikely to happen.
|
publication
|
[
[
"Health"
]
] |
[
[
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W1637106354
|
PROCESS FOR THE PRODUCTION OF TERT-BUTYL (E)-(6-[2- [4-(4-FLUOROPHENYL) -6-ISOPROPYL-2-[ METHYL (METHYLSULFONYL) AMINO] PYRIMIDIN-5-YL] VINYL](4R, 6S)-2,2-DIMETHYL [1,3]DIOXAN-4-YL) ACETATE
|
The invention concerns a process for the manufacture of <u>tert</u>-butyl (E)-(6-[2- 4-(4-fluorophenyl) -6-isopropyl-2-[ methyl (met hylsulfonyl) amino] pyrimidin-5-yl] vinyl}-(4R, 6S)-2,2-dimethyl [1,3-dioxan-4-yl) acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
|
patent
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
GB 0000481 W
|
Sustainable urban neighbourhoods - research and implementation support in europe
|
SUNRISE will develop, implement, assess and facilitate learning about new, collaborative ways to address common mobility challenges at the neighbourhood level. Towards this aim, 6 cities will foster collaborative processes in specific neighbourhoods as “Neighbourhood Mobility Labs” with the explicit mandate to implement innovative solutions for and with their residents, businesses etc.
SUNRISE rests on several pillars: A) Utilisation of neighbourhood-specific opportunities. B) Co-creation of solutions, i.e. through strategic civic-public alliances C) Socio-technical nature of solutions as combinations of services, social arrangements, rules, technologies or small infrastructures etc. D) New forms of synergies between bottom-up and top-down.
All SUNRISE activities are structured along the following phases of the innovation chain: 1) Co-identification of mobility problems; 2) Co-planning / co-selection of solutions; 3) Co-implementation of solutions; 4) Co-evaluation; 5) Co-learning and uptake.
The SUNRISE action neighbourhoods will use a blend of proven state-of-the-art online and face-to-face participation techniques and will establish longer-term collaborative forums. These will systematically involve citizens, businesses, NGOs, local authorities, academics etc. – always with a view to also involve under-empowered sections of the population like migrants, women, older and young people.
Alongside the mobility benefits for the action neighbourhoods, the project will result in a suite of products – most prominently the SUNRISE Neighbourhood Mobility Pathfinder – which will be provided to European cities, their stakeholders and citizens through a powerful exchange process to inspire and inform change across Europe. This will include a group of 20 Take-Up neighbourhoods and various city networks in cooperation with CIVITAS.
In strategic terms, SUNRISE will lay the foundation for a Sustainable Neighbourhood Mobility Planning concept (SNMP) to complement SUMPs.
|
project/european
|
[
[
"Climate, Energy and Mobility",
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Clean, safe and accessible transport and mobility",
"Communities and cities",
"Energy systems and grids"
]
] |
220617
|
Hybrid Systems with Constraints
|
Control theory is the main subject of this title, in particular analysis and control design for hybrid dynamic systems. The notion of hybrid systems offers a strong theoretical and unified framework to cope with the modeling, analysis and control design of systems where both continuous and discrete dynamics interact. The theory of hybrid systems has been the subject of intensive research over the last decade and a large number of diverse and challenging problems have been investigated. Nevertheless, many important mathematical problems remain open. This book is dedicated mainly to hybrid systems with constraints; taking constraints into account in a dynamic system description has always been a critical issue in control. New tools are provided here for stability analysis and control design for hybrid systems with operating constraints and performance specifications.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Emerging enabling technologies"
]
] |
W807008903
|
Environmental problems of the Greeks and Romans: ecology in the ancient Mediterranean
|
In this dramatically revised and expanded second edition of the work entitled Pan's Travail, J. Donald Hughes examines the environmental history of the classical period and argues that the decline of ancient civilizations resulted in part from their exploitation of the natural world. Focusing on Greece and Rome, as well as areas subject to their influences, Hughes offers a detailed look at the impact of humans and their technologies on the ecology of the Mediterranean basin. Evidence of deforestation in ancient Greece, the remains of Roman aqueducts and mines, and paintings on centuries-old pottery that depict agricultural activities document ancient actions that resulted in detrimental consequences to the environment. Hughes compares the ancient world's environmental problems to other persistent social problems and discusses attitudes toward nature expressed in Greek and Latin literature. In addition to extensive revisions based on the latest research, this new edition includes photographs from Hughes' worldwide excursions, a new chapter on warfare and the environment, and an updated bibliography.
|
publication
|
[
[
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Social and economic transformations",
"Culture, cultural heritage and creativity"
]
] |
W585087285
|
WAFER LEVEL CAPPED SENSOR
|
A sensor has a die (with a working portion), a cap coupled with the die to at least partially cover the working portion, and a conductive pathway extending through the cap to the working portion. The pathway provides an electrical interface to the working portion.
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
US 2006/0007576 W
|
Architecture Analysis of Business Intelligence Products in Japan
|
INTRODUCTIONToday, business intelligence (BI) has attracted the attention of the public given the increase in the power of the PC. BI is a concept, methodology, activity, or IT system that holds a significant amount of data internally and, externally and enables a company's results to be analyzed, with the results utilized during business administration decision making (NTT Data Corporation, 2009). Figure 1 illustrates a common BI system structure. In the past, SCM (supply chain management), CRM (customer relationship management), POS (point of sales), or ERP (enterprise resource planning) systems were installed at a company but the data were managed separately for each system. In a BI system, ETL (extract, transform, load) manages all of the data in all of a company's systems through which the data are interrelated with one another. The data are stored in a DBMS (database management system) for DWH (data warehouse) purposes and used for statistical analyses, data mining, text mining, or simulations. The analytic results are displayed using report tools or dashboard systems and are shared across the entire organization.To achieve its goals, simply installing a BI system is insufficient; therefore, how a company uses a BI system after its installation is a key success factor and an important feature of such systems. The methods for analyzing data using BI systems cannot be manual because they depend on the purpose of the installation, the business situation, or the condition of the data. Therefore, providing consulting services to develop methods for utilizing a BI system is important to customers' success, and the excellence of consulting services is said to be strongly related to the success or failure of BI vendors.This paper uses the product architecture framework to attempt to clarify the key success factors (KSFs) of a BI vendor's business that provides the combination of BI software and consulting services. The following are the research questions that this paper addresses.What are the strategies for software products and consulting services that result in success in the BI market?How do the product and service strategies affect a company's competitive advantage?PREVIOUS STUDIES ON PRODUCT ARCHITECTURE AND THEIR RELATIONSHIP TO THIS STUDYProduct architecture is a concept that expresses the relationship among the components of a product and is used to discuss the alignment between organization structure and product architecture (Baldwin & Clark, 2000; Fujimoto, Takeishi, & Aoshima, 2001). Product architecture consists of two parameters. One parameter is the modularity among a product's components, and the other parameter is the openness of the interface among the components. Product architecture is widely used to analyze automobile, semiconductor, software, and financial service industries (Fujimoto, Takeishi, & Aoshima, 2001).For example, in the analysis of the automotive industry, the product architecture dynamics of car production systems and partnerships among suppliers were analyzed by comparing Japanese automotive companies with European companies (Takeishi, Fujimoto & Ku, 2001). The result revealed that there were some modularization trends in automotive industries, in which the integral architecture had been common.In the analysis of the software industry, a development project relating to Linux OS (operating system) for personal computers was analyzed using product architecture (Koyama & Takeda, 2001). In the first Linux project, the software structure was strictly defined; however, the size of the software increased from 320,000 bytes in September 1991 to 90,000,000 bytes in May 2000, which means that the efficiency of the software had declined. This result indicates that it is highly difficult to define the module structures and the interface between modules at the inception of software development projects.In the analysis of the service industry, Japanese financing services were analyzed using product architecture (Usuki, 2001). …
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data"
]
] |
W2189297990
|
A unified online directed acyclic graph flow manager for multicore schedulers
|
Numerous Directed-Acyclic Graph (DAG) schedulers have been developed to improve the energy efficiency of various multi-core systems. However, the DAG monitoring modules proposed by these schedulers make a priori assumptions about the workload and relationship between the task dependencies. Thus, schedulers are limited to work on a limited subset of DAG models. To address this problem, we propose a unified online DAG monitoring solution independent from the connected scheduler and able to handle all possible DAG models. Our novel low-complexity solution processes online the DAG of the application and provides relevant information about each task that can be used by any scheduler connected to it. Using H.264/AVC video decoding as an illustrative application and multiple configurations of complex synthetic DAGs, we demonstrate that our solution connected to an external simple energy-efficient scheduler is able to achieve significant improvements in energy-efficiency and deadline miss rates compared to existing approaches.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Emerging enabling technologies"
]
] |
W2151663754
|
Find your passion for science on researchers night
|
Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences (IAR&FR), in partnership with Olsztyn School of Higher Education (OSHE) invites kids, tweens, teens and adults to join FUSION Researchers’ Night – a unique occasion when science, entertainment and education meet in one place! Fusion Night is an incredible blend of research, innovation, fun and education that introduces young people to meet scientists who live in their city but whose work reaches across the whole world.
The FUSION Night (FN) programmes revolves around the activities that will increase the awareness of the community at large about the importance of research careers and the central role of scientists in improving the daily life and well-being of European citizens. Visitors of the FN will have a chance to join edutaining activities, become a researcher for one night and give lecture to their peers (Polish Academy of Kids), test the content of vitamins in juice or milk (“Vitamins fusion or health illusion?), discover the secrets of cryopreservation in a mobile laboratory (“Ice land”), develop their own creams using fruit powders (“Tasty skin”), design a book from scratch (“Night in the Library”), learn the secrets of animal biodiversity (“Take a walk on the wide side”) or make a fruit puree in liquid nitrogen (“Molecular Show of Fusion Kitchen”). Sport enthusiasts can expect swimming competitions, basketball game, salsa course and martial arts training all conducted by our young researchers. We haven’t forgotten about the music and art lovers too, preparing for them a live concert of an international group of English teachers and an exhibition of science curiosities captured on the stained glass. Collaboration with partners from industrial circles will help to provide visitors with a first-hand view of the products and innovations “born” thanks to the solutions provided by science and researchers.
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project/european
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
176139
|
RENEWING REGISTRATIONS FOR CLIENT APPLICATIONS INSTALLED ON DIFFERENT PROXIMATE CLIENT DEVICES
|
In an embodiment, a client device obtains a list of client devices registered in association with a particular client application, and then detects listed client device(s) as proximate via a local communications interface. One of the proximate client devices is identified as responsible for sending an aggregated registration request message for renewing their respective application registrations with a server. In another embodiment, the server receives a registration message for the client application from a client device and detects that at least one other registered client device for that client application is proximate to the requesting client device. The server attempts to preemptively renew the registrations for both the requesting client device and the at least one other registered client device based on the proximity detection.
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Artificial intelligence and robotics"
]
] |
US 2016/0025878 W
|
Molecular design of polymers for biomedical applications
|
MEDIPOL (“Molecular Design of Polymers for Biomedical Applications”) is an interdisciplinary, international and intersectoral collaborative effort that utilises the mechanism of personnel exchange between partners located in the EU and Asia to address key aspects of problems of huge international socioeconomic importance. Through carefully planned and integrated secondments MEDIPOL will use knowledge transfer to train 29 ESRs and 20 ERs to be future leaders in both academia and industry. The specific major problems that we shall tackle affect vision and mobility, which are becoming increasingly critical issues in healthcare systems across the world, where the growing socio-economic difficulties of ageing populations are evident at both individual and governmental levels. MEDIPOL is designed to identify, design, develop and disseminate understanding of materials and technologies for systems that will aid and augment the healthy ageing of ocular and dermal tissue. Key to achieving this lies in harnessing the understanding of the moist ocular surface and its relevance to compromised dermal tissue. There are clear links between ocular and dermal sites. Importantly, understanding these analogies facilitates the design of contact lenses especially for use as corneal bandages, of ophthalmic dry eye therapies and of successful burn and wound dressings. These issues are international, they affect quality of life and they are of very significant social and economic importance in both developing and developed economies.
MEDIPOL is an integrated 4-year program of knowledge transfer and networking between Aston University, UK (Aston), i+Med S. Coop, Spain (i+Med), Technical University of Liberec, Czech republic (TUL), Chiang Mai University, Thailand (CMU), Naresuan University, Thailand (NU) and Mae Fah Luang, Thailand (MFU). The overarching objective of the proposed joint exchange programme is to establish long-term stable research cooperation between all partners.
|
project/european
|
[
[
"Health",
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
2730461
|
Ultrasound diagnostic apparatus and signal processing method thereof
|
The presently disclosed subject matter is intended to correctly determine an ambient sound velocity at each level of pixels or line images constituting an ultrasound image, and construct a high-precision ultrasound image. A region-of-interest setting unit sets a region of interest on an ultrasound image. A transmission focus control unit gives a transmission focus instruction, so that a transmitting circuit performs transmission focusing on the region of interest. A set sound velocity specification unit specifies a set sound velocity used to perform reception focusing on RF data. A focus index calculation unit performs reception focusing on the RF data for each of a plurality of set sound velocities to calculate the focus index of the RF data. An ambient sound velocity determination unit determines the ambient sound velocity of the region of interest on the basis of the focus index for each of the plurality of set sound velocities. In other words, the local sound velocity of the region of interest is determined by optimising the ultrasonic image focusing.
|
patent
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
EP 13173604 A
|
Perceived fear appeals and examination performance: Facilitating or debilitating outcomes?
|
Abstract This study examines whether students' perception of classroom fear appeals concerning a forthcoming high-stakes examination are associated with facilitating or debilitating performance outcomes. Self-report data were collected for perceived fear appeals, test anxiety and achievement goals from a sample of 273 students in their final year of secondary schooling along with their examination performance in a high-stakes Mathematics examination. Data were analysed using structural equation modelling and a mediated model accepted. The perceived frequency of fear appeals relating to the timing of examinations were positively related to examination performance through a mastery-approach goal and when fear appeals were perceived as threatening they were inversely related to examination performance through a performance-avoidance goal and both the worry and tension components of test anxiety. Given that perceived fear appeals are associated with mixed outcomes, teachers and educators should be advised to use fear appeals with caution.
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publication
|
[
[]
] |
[
[]
] |
W2084919485
|
Patrocínio por empresas de alimentos e bebidas no futebol: análise da Copa América 2019
|
To identify the sponsorship by food and beverage companies of the teams participating in the 2019 Copa América Soccer Cup and associate this sponsorship with characteristics of the teams and their respective countries.The sponsors of the 10 teams participating in the 46th edition of the Copa América were identified. These entities were classified into (i) food companies, (ii) alcoholic beverage companies, and (iii) other segments. The food companies were classified according to their products, according to the NOVA classification. In addition, data on the number of titles previously won by the teams in the Copa America and the World Cup were obtained, as well as data on the countries' Human Development Index, annual per capita sales of ultra-processed foods, and annual per capita consumption of alcoholic beverages.A total of 89 sponsorships were identified for the 10 teams studied, some of these supporting two or more teams. Eighteen percent of the sponsors were food companies, with 12.4% being ultra-processed foods. The alcoholic beverage category represented 7.9% of the sponsors. Ultra-processed beverage and alcoholic beverage companies sponsored seven of the 10 teams studied. We noted higher participation of ultra-processed foods company sponsors in teams from countries with higher Human Development Index, sales of ultra-processed foods, and number of Copa América and World Cup titles. The sponsorship by alcoholic beverage companies was higher for teams from countries with lower Human Development Index, alcohol consumption, and number of Copa América and World Cup titles.A significant presence of ultra-processed food and alcoholic beverage companies as sponsors of South American soccer teams was noted, along with the fact that sport performance characteristics of the teams and socioeconomic and market issues of the countries are associated with the occurrence of sponsorship.
|
publication
|
[
[
"Health",
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Healthcare systems",
"Environmental and social health determinants"
]
] |
W4281937464
|
On the Prevention of Inflation and Deflation
|
The depreciation of U.S.dollar,the subprime mortgage crisis and the dramatic fluctuating of commodity price in the first half of 2008 results in imported inflation and the pressure of constitutive inflation caused by the natural disaster in China emerges.As the effects of inflation governance and control policy gradually appear,the price index decrease month by month,and the pressures of the inflation become lightened.However,the international environment dramatically changes into the financial crisis,which seriously impacts on the economic entities of the world.The quick declination in economic growth and the appearance of economic recession slow down the economic growth of China.The inflation quickly transformed into the deflation.Controlling goal is taken as maintaining growth,expanding domestic demand and adjusting structure.
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publication
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[
[]
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[
[]
] |
W2367504513
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(7429.31052017.113000220_1632) SMARTISS
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THE BASIC IDEA OF THE PROJECT? TO RETURN VALIDITY? TECHNICAL AND ECONOMIC TO THE TYPICAL STRUCTURAL SYSTEM OF THE SELF-SUPPORTING WAREHOUSE WHOSE DESIGN? IT HAS BECOME VERY PROBLEMATIC BOTH WITH REGARD TO ANTI-SEISMIC SIZING AND WITH REGARD TO CHECKS RELATED TO THE CONTROL OF MODES? COLLAPSE ON THE OCCASION OF A FIRE SCENARIO. IN PARTICULAR, IS IT DIFFICULT TO COEXIST THE PRINCIPLES BEHIND THE RECENT ANTI-SEISMIC DESIGN CALLED?CAPACITY DESIGN? (DUTTILIT? AND FLEXIBILITY? OF THE STRUCTURES) WITH THOSE AT THE BASE OF THE SO-CALLED?FIRE ENGINEERING? (INCREASED THICKNESS AND STRUCTURAL STIFFNESS). IN THIS ALREADY? SHOULD ROBUSTNESS (E.G. IMPACT ON STRUCTURES GENERATED BY INTERNAL HANDLING VEHICLES) AND DURABILITY BE ADDED? (APPEARANCE RELATED TO INSPECTION AND MAINTENANCE OF STRUCTURES, ACTIONS OFTEN NOT SIMPLE GIVEN THE GEOMETRY AND ABOVE ALL THE ALT
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project/regional
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[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Key digital technologies",
"Emerging enabling technologies",
"Manufacturing technologies"
]
] |
Q4941164
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Comparative Study of Green Fruit Extract of Melia azedarach Linn. With its Ripe Fruit Extract for Antileishmanial, Larvicidal, Antioxidant and Cytotoxic Activity
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The present study was carried out to compare the potential of green and ripen fruits aqueous extract against antileishmanial, larvicidal, antioxidant and brine shrimp cytotoxicity assay. A general antileishmanial, larvicidal, antioxidant and cytotoxic assays were performed at different concentrations. The green fruits expressed significant activity against L. tropica (LC 50 =0.41µg/mL), while the ripe fruits showed less activity (LC 50 =8227.51µg/mL). Upon larvicidal activity against Culex quinquefasciatus larvae, the green fruits extract expressed excellent results with LC 50 value 67.65µg/mL while ripe fruits showed less activity with LC 50 value 7171.18µg/mL. Similarly, for cytotoxicity assay for green and ripe fruits the LC 50 value obtained were 18.07µg/mL and 530.2µg/mL, respectively. The result for antioxidant potential showed that only the green fruits has some antioxidant potential (IC 50 232.23µg/mL) compared to ripe fruits (>1000µg/mL) against the reference drug (ascorbic acid). The total phenolics contents of the green fruits expressed good concentration 10.54 mg/g DW while ripe fruits have 5.32 mg/g DW. From these results it can be concluded that green fruits has more active compounds than ripe fruits. The green plant material can be used as good source of antiprotozoal, insecticidal and anti-cancerous candidate.
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publication
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[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Non-communicable and rare diseases",
"Environmental and social health determinants",
"Tools, technologies and digital solutions for health and care, including personalised medicine",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W2228271668
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Fourier analysis for/and partial differential equations
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This project aims to develop the field of Harmonic Analysis, and more precisely to study problems at the interface between Fourier Analysis and PDEs (and also some Geometry).
We are interested in two aspects of the Fourier Analysis :
(1) The Euclidean Fourier Analysis, where a deep analysis can be performed using specificities as the notion of ``frequencies'' (involving the Fourier transform) or the geometry of the Euclidean balls. By taking advantage of them, this proposal aims to pursue the study and bring novelties in three fashionable topics : the study of bilinear/multilinear Fourier multipliers, the development of the ``space-time resonances'' method in a systematic way and for some specific PDEs, and the study of nonlinear transport equations in BMO-type spaces (as Euler and Navier-Stokes equations).
(2) A Functional Fourier Analysis, which can be performed in a more general situation using the notion of ``oscillation'' adapted to a heat semigroup (or semigroup of operators). This second Challenge is (at the same time) independent of the first one and also very close. It is very close, due to the same point of view of Fourier Analysis involving a space decomposition and simultaneously some frequency decomposition. However they are quite independent because the main goal is to extend/develop an analysis in the more general framework given by a semigroup of operators (so without using the previous Euclidean specificities). By this way, we aim to transfer some results known in the Euclidean situation to some Riemannian manifolds, Fractals sets, bounded open set setting, ... Still having in mind some applications to the study of PDEs, such questions make also a connexion with the geometry of the ambient spaces (by its Riesz transform, Poincaré inequality, ...). I propose here to attack different problems as dispersive estimates, ""L^p""-version of De Giorgi inequalities and the study of paraproducts, all of them with a heat semigroup point of view.
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project/european
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[
[]
] |
[
[]
] |
173460
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Understanding successive industrial revolutions: A “development block” approach
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Abstract This paper provides a reappraisal of the literature on “long waves” and “general purpose technologies”. This approach is still widely used to characterize long run trends of technological change and economic development since the first industrial revolution. Notwithstanding providing some useful insights, it is argued that this approach is rooted in a too rigid historical chronology positing a tight connection between technological change to economic outcomes. On these grounds, the paper suggests that a more flexible interpretative framework based on the notion of successive industrial revolutions and “development blocks” may offer a more accurate historical account and be more useful for providing insights for innovation and sustainability policies.
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publication
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Manufacturing technologies"
]
] |
W2901712740
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Catalytic csp3-h functionalization via carbene insertion meets sustainability: developing an unprecedented iron methodology
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Proposed to break new ground quickly and to establish new frontiers in cutting-edge Csp3-H functionalization chemistry, this proposal focuses on the development and exploitation of iron catalysed carbene transfer towards saturated hydrocarbons, a vast and low cost feedstock for the synthesis of more valuable chemicals. By rational design and evaluation of low toxicity and low cost iron complexes equipped with different electronic and steric properties, new environmental benign and sustainable catalytic strategies will be instilled into this promising synthetic methodology. Extending beyond the confines of traditional precious metals catalysed carbene transference, new non-hazardous sources for these fragments, compared with the currently employed diazocompounds, will be designed and refined in sulfur ylide compounds and zinc carbenoid reagents. The project will benefit from the accumulated wealth of experience of the candidate Dr. Hernán-Gómez in synthesis, characterization and kinetic studies of highly reactive organometallic reagents, spanning from transition metals to main group elements. This will offer valuable mechanistic insights into the investigated processes, including unequivocal identification of the catalytic active species, key aspects to progress the proposed project. Additionally, through collaboration with supervisor Prof. Costas, an internationally recognised leader in the chemistry of iron compounds applied to organic synthesis, Dr. Hernán-Gómez will be provided with the required support to successfully push forwards the frontiers of the proposed research line in the field of iron chemistry, a stepping stone towards achieving a senior academic position.
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Net-zero and less polluting Industries",
"Emerging enabling technologies",
"Circular systems",
"Advanced Materials"
]
] |
884553
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Engineering quantum error correction
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This proposal will advance the theory of quantum error correction towards its application in real physical devices, in particular superconducting transmon qubit systems. The research will result in proposals for experiments: how to use physical qubits to redundantly represent logical quantum information and how error information can be obtained and classically processed. The research will consider novel ways of using transmon qubits to achieve a universal fault-tolerant surface code architecture. The research will produce a design of a universal fault-tolerant architecture in which qubits are encoded in the electromagnetic field of a (microwave) cavity. Research will also focus on mathematical and numerical studies in quantum error correction which are technology-independent, but shed light on coding overhead, decoding efficiency and logical universality.
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project/european
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[
[]
] |
[
[]
] |
170836
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Doña Ivone Lara: La enfermera que luchó por los derechos de los pacientes psiquiátricos
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Introducción: La enfermería brasileña contiene varios profesionales destacados que contribuyeron al avance de la enfermería en Brasil, y uno de ellos es Ivone Lara da Costa, también conocida como la Dama do Samba. Durante su vida fue enfermera, trabajadora social y terapeuta ocupacional, ejerciendo gran influencia en el escenario de la salud mental de su época, influyendo hasta la actualidad. Enfrentó una sociedad machista, condiciones socioeconómicas bajas y ser huérfana de padre y madre a los 12 años no la alejó de su sueño de mejorar su situación. Cultivó un amor por la samba que luego se unió al conocimiento de la práctica de enfermería como herramienta en el tratamiento de pacientes psiquiátricos. Objetivos: Investigar las contribuciones de la enfermera Ivone Lara a la enfermería brasileña. Metodología: Se trata de una revisión narrativa, cuyo objetivo es identificar el 'estado del arte' de un tema dado. Para la elaboración de esta investigación se realizaron búsquedas en bases de datos y noticias de fuentes de enfermería. Resultados: Su carrera en enfermería comenzó a los 17 años, nunca dejó de estudiar, ya pesar de formarse en otras áreas, dejó un legado en enfermería. Su principal legado fue en el campo de la psiquiatría, donde trabajó durante 30 años en el Instituto de Psiquiatria do Engenho de Dentro, en Río de Janeiro, trabajando codo a codo con el médico psiquiatra Nise da Silveira, donde se desarrolló el movimiento por la humanización de los enfermos mentales ganaron reconocimiento internacional. Luchó contra las técnicas agresivas utilizadas en la época, como el electroshock, la lobotomía y otros métodos agresivos, y abrió un debate por el fin del encierro institucional de los enfermos mentales, proponiendo como tratamiento la terapia ocupacional y la musicoterapia, influido por samba, con el fin de establecer un vínculo entre el paciente y la vida en sociedad. Trabajó intensamente en un intento por reinsertar a los pacientes en la familia, muchas veces recorriendo grandes distancias, teniendo un rol articulador, buscando siempre insertar expresiones artísticas, culturales y de ocio, siendo revolucionaria para su época. Durante su práctica, descubrió que varios pacientes que eran excelentes músicos tocando el piano, la pandereta y el cavaquinho, estableció en el Instituto donde trabajaba el “día de los enfermos”, que era un día especial en el que los pacientes que querían participar, hacían sus presentaciones artísticas, generando resultados positivos. Consideraciones finales: La trayectoria de la enfermera doña Ivone Lara muestra la importancia de las enfermeras para desarrollar soluciones frente a un problema social con el fin de buscar la humanización y satisfacer las necesidades de los pacientes, sirviendo de ejemplo para las generaciones futuras. La musicoterapia también demuestra ser una próspera intervención de enfermería para la salud mental y otras áreas, colocando a la enfermería en el centro de la atención.
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publication
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[
[
"Health",
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Health throughout the life course",
"Healthcare systems",
"Environmental and social health determinants"
]
] |
W4321513041
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Developing Appropriate Methods for Cost-Effectiveness Analysis of Cluster Randomized Trials
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Aim. Cost-effectiveness analyses (CEAs) may use data from cluster randomized trials (CRTs), where the unit of randomization is the cluster, not the individual. However, most studies use analytical methods that ignore clustering. This article compares alternative statistical methods for accommodating clustering in CEAs of CRTs. Methods. Our simulation study compared the performance of statistical methods for CEAs of CRTs with 2 treatment arms. The study considered a method that ignored clustering—seemingly unrelated regression (SUR) without a robust standard error (SE)—and 4 methods that recognized clustering—SUR and generalized estimating equations (GEEs), both with robust SE, a “2-stage” nonparametric bootstrap (TSB) with shrinkage correction, and a multilevel model (MLM). The base case assumed CRTs with moderate numbers of balanced clusters (20 per arm) and normally distributed costs. Other scenarios included CRTs with few clusters, imbalanced cluster sizes, and skewed costs. Performance was reported as bias, root mean squared error (rMSE), and confidence interval (CI) coverage for estimating incremental net benefits (INBs). We also compared the methods in a case study. Results. Each method reported low levels of bias. Without the robust SE, SUR gave poor CI coverage (base case: 0.89 v. nominal level: 0.95). The MLM and TSB performed well in each scenario (CI coverage, 0.92–0.95). With few clusters, the GEE and SUR (with robust SE) had coverage below 0.90. In the case study, the mean INBs were similar across all methods, but ignoring clustering underestimated statistical uncertainty and the value of further research. Conclusions. MLMs and the TSB are appropriate analytical methods for CEAs of CRTs with the characteristics described. SUR and GEE are not recommended for studies with few clusters.
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publication
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[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Healthcare systems"
]
] |
W2101104998
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Paleogenetic extraction and analysis from challenging environments
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The field of ancient human DNA (aDNA) has rapidly undergone changes over the last decade. These changes have been spurred on through the use of high-throughput sequencing (HTS) technologies. These methodological advancements have increased our understanding of the human lineage to depths thought impossible only a short time ago. For example, aDNA research has shown how modern humans are related to our archaic ancestors, indicating significant admixture events throughout our evolutionary history with the Neanderthals and other now-extinct archaic species. However, to achieve these results, the ancient material has been exceptionally well preserved, owing to favorable, i.e. cold, environmental conditions. For many parts of the world, however, the environmental conditions remain a barrier to the extraction and analysis of aDNA.
The nature of aDNA research is inherently interdisciplinary, whereby several branches of inquiry, such as archaeology or genetics, attempt to answer similar evolutionary questions from different perspectives. This proposal attempts to use advanced extraction and sampling methods for aDNA from challenging environments in order to broaden the scope of paleogenetics research. Although continental Europe has gained significantly from these advances, for other parts of the world, such as Southeast Asia and the Near East, this has been more difficult due to formidable preservation conditions. The goal of this proposal is to build on promising preliminary results that target a specific bone in the human skull in order to gain a better understanding surrounding the dynamics of aDNA preservation, while at the same time, gain insight into the evolutionary histories of peoples from warm and humid, or warm and arid, locations. Our proposal incorporates state-of-the-art HTS techniques, includes a comprehensive training program with international collaborators, and benefits from a two-way transfer of knowledge between host and researcher.
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project/european
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[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[]
] |
170699
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INPUT DEVICE FOR CONTROL SIGNALS FOR CONTROLLING THE MOVEMENT OF AN OBJECT REPRESENTED ON A DISPLAY DEVICE AND GRAPHIC DISPLAY HAVING SAID INPUT DEVICE
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The input device for control signals for controlling the movement of an obje ct represented on a display device is fitted with a housing (24) and three control signal generating devices (38, 40, 42) to generate first control signals. The input device also comprises three actuating organs (32, 34, 36) disposed orthogonally in relation to each other, wherein each organ is mount ed in such a way that it may be displaced linearly along a spatial axis (x, y, z) on or in the housing (24) and protrudes outwards above the housing (24) in t wo opposite areas of said housing (24). Each actuating organ (32, 34, 36) interacts with one of the control signal generating devices (38, 40, 42), wherein the control signal generating devices (38, 40, 42) generate the firs t control signals depending on the displacement position of the actuating orga ns (32, 34, 35). Spatial orientation of the housing (24) is recognized by a position recognition sensor (46) and representation on the display is adjust ed in correspondence with the position and location of the housing (24).</SDOAB >
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies"
]
] |
CA 2339289 A
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BATTERIES HAVING COILED ELECTRODE PLATE GROUP
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A battery (100) comprises a coiled electrode plate group which comprises a positive electrode plate (120), a negative electrode (130) plate and an insulating separator sheet (140). The separator sheet (140) provides electrical insulation between the positive and negative plates (120, 130). The insulating separator sheet (140) comprises a first longitudinal portion, a second longitudinal portion and a intermediate perforated portion (148) between the first and second longitudinal portions.
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
IB 2012051739 W
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Integrated tissue slice culture and nmr metabolomics – a novel approach towards systemic understanding of liver function and disease
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We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolic
study of tissues at the system level.
Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level.
The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.
It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.
TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease.
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project/european
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[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
217803
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Analyzing different aspects of social network usages on students behaviors and academic performance
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The role of social networks has become increasingly relevant in recent years. This research focuses on analyzing the affect of social networks (SN) websites usage on students' behaviors and academic performances. This investigation included students gender based usage patterns of social networks websites with respect to our proposed websites scheme. We classified all students with similarity of social networks usage patterns for predicting their future behaviors, in addition we analyzed affect of SN usage on each groups of users academic performance based on their undertaken programs, semester and usage pattern including total time spent in SN websites during a day and the types of SN websites that visited by them, or identifying any changes in usage patterns of users during different days including final examination days or holidays if existed.
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publication
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[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics"
]
] |
W2096383424
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FLOAT FOR USE IN WATER-BASED SECURITY SYSTEM
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Embodiments of this invention describe a float for use with a running gear entanglement system ("RGES") deployed on water, in addition to an improved system and method for using an RGES deployed in water. The floats lock securely onto the RGES mainline rope. The floats may be stacked for additional buoyancy or to allow for multiple RGES ropes in the same deployment. The floats are designed to permit the RGES to be retrieved/stored on and deployed from a reel. The floats may be constructed of any color and may also be luminescent. The floats may be ballasted to assist in anchoring the RGES.
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patent
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[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Emerging enabling technologies",
"Circular systems"
]
] |
US 2007/0016131 W
|
Aquabuddy-Care: a groundbreaking solution for elderly and disabled people with reduced mobility that finally enables caregivers to effectively and safely bathe/shower them in their own beds.
|
The progressive ageing of the population is becoming a major problem for society, who sees how ageing comes accompanied by crucial challenges that constraint our healthcare systems. Dependency is one of these challenges, adopting today the form of over 3 million Europeans unable to live independently due to ageing, disease, accidents or long term disability. These individuals rely and depend on caregivers to accomplish daily activities, being hygiene one of the most critical steps. Fulfilling hygiene tasks becomes specially challenging and time-consuming for the saturated personnel at hospitals, clinics or elderly homes, who need to be extra careful with these patients at higher risk of infection. The complexity of the current processes to wash or bathe bedbound patients (which involves transferring the patient out of bed) enters in conflict with the workload pressure faced by caregivers (which limits the time available for each patient). In response, we have developed and validated Aquabuddy-CARE (AQB), a miniaturized and portable shower system that enables patients to undertake hygiene tasks in bed, rapidly and in a dignified manner. The combination of advanced materials, sustainable production process and proprietary water flow system guarantees the efficiency of the technology concerning water consumption and prevention of contamination. After completing the validation at the pilot scale, this project aims to finalise the industrialization and field-testing of AQB. The Feasibility Study planned in Phase 1 will help us secure the project from all technical, financial and commercial standpoints. Once in the market, AQB will bring significant benefits for caregivers and patients worldwide, helping to alleviate the raising impact of ageing and disability while improving their life quality. In turn, AQB will boost our growth, expecting to hire 12 new people in 5 years, gain €11.2 million in profits and reach a ROI of 4.6 per euro invested in the project.
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project/european
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[
[
"Health",
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Health throughout the life course",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
218554
|
Novel system for surface inspection and quality control for steel industries.
|
European and global steel industry are facing several challenges, including meeting the high international quality standards.
ISEND is a SME founded in 2006 and a acknowledged worldwide expert in industrial Non Destructive Test (NDT) systems that is participated by the Venture Capital ”Sodical” to support its international growth. ISEND has identified a need from its customers (spread trough Europe, Asia, North&South America) in a specific niche market of the Hot rolling mill industries for metal wire rod to which the current commercial solution have strong weakness.
In this market, the producers are required to fulfil quality standards for surface cracks lower than 1% of diameter. Claims from customers against the lack of these standards can reach 4% of total plant year production. Surface cracks inspection technologies, are difficult to implement due to plants harsh environment (1200 ºC and rolling speeds up to 120 m/s), massive production rates (>10 Mton/year). Those systems must also deal with different alloy grades, applications, and final product sizes (diameters covers from 5 to 90 mm, wire coil lengths range is from 14,000 m to 750 m).
Our proposed system EddyEyes® is a surface quality control system for Non Destructive Testing of metal products in production plants and is able able to detect, locate, display and storage surface cracks as smaller as 50 µm deep at 120 m/s rolling speed and 1200 ºC temperature in continuous operation.
EddyEyes® selling price would be 0,4M€ (50% lower than our main competitors) what will allow the enduser payback period be less than 1 year.
We have estimated that the worldwide market size for this product will be of 2.000 industries, from which we forecast that at least 20% will be interested in an improved quality control system.
We foresee to be able in 5 years to position ourselves as leader in this niche market, reaching around 20% of the worldwide market and a turnover of 24 Million euro and creating 80 employees
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Circular systems",
"Manufacturing technologies"
]
] |
185333
|
Collaborative robotic solution for advanced inspection of complex composite parts
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Highly integrated composite parts have begun to enter the market. Their inherent complex structure makes more difficult inspection activities being crucial the development of more flexible, more reliable and faster NDT solutions.
Regarding NDT methods, Ultrasonic testing (UT) techniques are suitable for the inspection of large and hidden areas and recently developed ones, like guided waves, have shown potential for remote inspection. Currently, most of inspections are performed manually, which entail two key disadvantages: an excessive amount of time and the possibility of potential safety failures due to human errors. To solve these issues, automation of inspection process has been envisioned as strategic solution. The integration of robotics in manufacturing lines has proved improvements in process reliability, reduction of manufacturing times and, therefore, costs. However, many industrial operations cannot be fully automated at a reasonable cost. In such a case, human-robot cooperation may be the most cost-efficient and productive solution.
This is precisely the scope of CRO-INSPECT. The project aims at creating a new concept of hybrid work cell for inspection, where humans and robots perform collaboratively inspection activities using advanced UT techniques. It aims at developing a sound inspection solution with enhanced robotic capabilities, enabling faster and more reliable inspections, and helping operator during the inspection of complex composite parts, reducing this way recurring manufacturing costs.
The specific goals of the project will be to generate an advanced and safe human/robot collaboration work cell prototype for robotic assistance of the operator during inspection; and to generate a new inspection system based on advanced UT, capable of reaching low access areas of parts. By achieving these objectives, the consortium expects to provide a step forward in the current industrial solutions for automated NDI of large aircraft components.
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics",
"Manufacturing technologies"
]
] |
185168
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Acquisition of measuring instruments, innovation of equipment, software for creating protocols and downloading data.
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Acquisition of a measuring instrument for measuring deviations and pulses of a specified meter – SM (tachograph), software for creating test reports and evaluating downloaded data from SM. SM data download machine. Computing technology as a whole. a.
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project/regional
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Manufacturing technologies"
]
] |
Q12917
|
Rôle des facteurs sociogéographiques dans la participation à un programme de réadaptation cardiaque après une angioplastie coronarienne
|
La réadaptation cardiaque (RC) après angioplastie coronaire pour syndrome coronarien aigu (SCA) ou chronique (SCC) est sous-utilisée en France, malgré son efficacité démontrée sur la morbi-mortalité et son rapport coût-efficacité favorable. L'objectif était d’étudier, à partir de bases de données de vie réelle, le rôle des caractéristiques sociogéographiques des patients dans leur participation à la RC. Les patients ayant bénéficié d'une angioplastie en Aquitaine en 2013 ont été sélectionnés à partir du registre Aquitain de cardiologie interventionnelle (ACIRA) apparié au PMSI SSR 2013-2014 (97 % des séjours retrouvés), pour identifier leur participation à la RC. A partir d'une analyse classique des bases de données, l'association entre les facteurs socio-géographiques (indice de défavorisation sociale-FDep09, accessibilité spatiale aux médecins généralistes-APL MG 2015, distance domicile-centre de RC le plus proche) et la participation à la RC à 1 ou 3 mois pour les SCA et à 6 mois pour les SCC) a été analysée par des modèles de régression logistique multivariée. Au total, 19,0 % des 2797 patients SCA inclus ont bénéficié d'une RC à 3 mois (11,3 % à 1 mois) et 10,1 % des 1361 patients SCC en ont bénéficié à 6 mois. Dans les deux populations, le faible accès aux médecins généralistes (SCA-RC 3 mois : OR=0,57 IC 95 % [0,39-0,83], SCA-RC 1 mois : OR=0,62 IC 95 % [0,40-0,96], SCC-RC 6 mois : OR=0,37 IC 95 % [0,19-0,73]) et le niveau social "intermédiaire" par rapport au niveau "très avantagé" (SCA-RC 3 mois : OR=0,42 IC 95 % [0,21-0,83], SCA-RC 1 mois : OR=0,44 IC 95 % [0,29-0,68], SCC-RC 6 mois : OR=0,40 IC 95 % [0,22-0,76]) étaient associés à une plus faible probabilité de participation à une RC à 1, 3 et 6 mois. L'association avec la distance au centre de RC n'était pas significative. Les politiques visant à promouvoir la participation à la RC doivent prendre en compte le rôle de l'accessibilité aux médecins généralistes et le niveau social qui semblent associés à la participation aux programmes de RC.
|
publication
|
[
[
"Health"
]
] |
[
[
"Healthcare systems",
"Environmental and social health determinants"
]
] |
W4221113285
|
Strategic Environmental Assessment application at transnational level to the Interreg Programmes and Projects
|
Problems addressed
• Lack of a systematic integration of environment into strategic decision-making.
• Lack of a standardised methodological approach and of operational tools for environmental assessment of plans, policies and programmes (PPP).
• Lack of clear and effective tools and of proper training for a consistent application of environmental assessment to Interreg Programmes and projects.
Objectives
• To increase the quality of the Interreg Programmes and projects, and to expand and support the activities undertaken by the INTERACT Points (Toll Box and Qualification and Transfer) and INTERACT Secretariat.
• To ensure that environmental consequences of Interreg Programmes and projects are properly identified and assessed.
• To promote a more transparent planning of policies, plans and programmes, and sustainable development, through the application of SEA.
Approach and methodology
• Innovatory approach which foresees the elaboration of a set of tools for the application of SEA to Interreg Programmes and projects, and the implementation of dissemination and capacity building activities.
• Review of the in-force legislation in EU countries concerning the evaluation of environmental effects of plans, policies and programmes, and of successful case-studies of SEA application, as baseline information for the planning of project activities.
• Close and synergic cooperation among project partners and steady participation of all stakeholders during the entire project, in order to promote empowerment and ownership.
|
project/regional
|
[
[
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Democracy and Governance"
]
] |
interreg_3792
|
Concerns about Novel Ecosystems
|
This chapter focuses on two types of concerns about novel ecosystems. The first concern is connected with misapprehensions that arise, mostly from lack of information or misunderstanding of the implications of managing novel ecosystems. These concerns should not be ignored or underestimated because they can easily obstruct an informed and constructive discussion about novel ecosystems and their management. The first misapprehension is that accepting or acknowledging novel ecosystems implies that managers will surrender any attempt to control invasive species. The second misapprehension addressed here is that acceptance of novel ecosystems will result in the replacement of traditional conservation and restoration practice. The second type of concern includes more persistent concerns about novel ecosystems. These are much more difficult concerns to work through because they require revisiting and possibly altering systemic patterns of social tradition and moral beliefs that pertain to nature and its conservation.
|
publication
|
[
[
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
W1517479391
|
Association between<i>Serine/Threonine Kinase 39</i>Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans
|
Although the association between single nucleotide polymorphisms (SNPs) of Serine/Threonine Kinase 39 (STK39) and hypertension has been reported, the prior studies have been inconsistent. The aim of this study is to evaluate the association between rs3754777 and rs6749447, the two SNPs of STK39, and hypertension and other cardiovascular risk factors in Koreans, residing in the Republic of Korea.We included 238 hypertensive patients and 260 controls. The associations between genotype and haplotype combination and hypertension were examined. In addition, possible SNP-related differences in the adjusted blood pressure and other cardiovascular risk factors were analyzed.There was no significant association between the two SNPs and hypertension. However, the carriers of AA genotype of rs3754777 showed lower blood glucose and cholesterol levels, particularly in females. Genotype of rs6749447 was associated with the waist circumference, triglyceride, and high density lipoprotein-cholesterol levels, only in gender-stratified analysis. The effects of haplotype combinations on risk factors were compatible with genotype effects of each SNP.Associations between the two SNPs of STK39, rs3754777 and rs6749447, and hypertension were not significant. However, the two SNPs showed genotype-related differences in blood glucose, lipids, and waist circumference, especially in women. Further studies are needed to clarify the effect of STK39 variants in these cardiovascular risk factors.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
W2029011797
|
Information security technology for applications : 16th Nordic Conference on Secure IT Systems, NORDSEC 2011, Talinn, Estonia, October 26-28, 2011 : revised selected papers
|
Invited Papers.-Designing a Governmental Backbone.-Internet Voting in Estonia.-Contributed Papers.-A Ring Based Onion Circuit for Hidden Services.-User Tracking on the Web via Cross-Browser Fingerprinting.-Comparison of SRAM and FF PUF in 65nm Technology.-Modular Anomaly Detection for Smartphone Ad Hoc Communication.-Mental Voting Booths.-Methods for Privacy Protection Considering Status of Service Provider and User Community.-The Security and Memorability of Passwords Generated by Using an Association Element and a Personal Factor.-Increasing Service Users' Privacy Awareness by Introducing On-Line Interactive Privacy Features.-Optimized Inlining of Runtime Monitors.-Identity-Based Key Derivation Method for Low Delay Inter-domain Handover Re-authentication Service.-Feature Reduction to Speed Up Malware Classification.-Rooting Android - Extending the ADB by an Auto-connecting WiFi-Accessible Service.-An Attack on Privacy Preserving Data Aggregation Protocol for Wireless Sensor Networks.-Disjunction Category Labels.-Visualization Control for Event-Based Public Display Systems Used in a Hospital Setting.-Exploring the Design Space of Prime Field vs. Binary Field ECC-Hardware Implementations.-
|
publication
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Key digital technologies",
"Artificial intelligence and robotics",
"Emerging enabling technologies",
"Advanced computing and big data"
]
] |
W568478334
|
Implementation framework for a fully flexible assembly system (F-FAS)
|
Purpose – This paper aims to provide a framework for the choice, design, set-up and management of a fully flexible assembly system (F-FAS). Many industrial applications for small batch productions require highly flexible automated manufacturing systems. Moreover, some extensions of the F-FAS concept are provided. Design/methodology/approach – The paper reviews recent findings regarding the F-FAS with a top-down approach, and defines an integrated implementation framework. This framework is structured into three strictly correlated phases, and the presented procedure is organized to be readily used for new industrial applications. Practical applications are presented to show how the system can satisfy flexibility demands in a variety of cases. Findings – The proposed framework is organized in three steps: convenience analysis of the F-FAS compared to a traditional flexible assembly system; an optimal design of the feeder; a choice of the set-up and sequencing algorithm yielding the highest throughput. Following these steps, the F-FAS can become an effective solution for small batch productions with frequent reconfigurations. However, due to the limited throughput, the system is not well suited for large batches. Originality/value – The presented framework allows to implement an F-FAS for a given industrial application, and to evaluate its efficacy with respect to other assembly technologies. Moreover, with the same implementation framework, the F-FAS concept can be applied to production fields that are different from assembly, as shown by the provided examples. This represents an important element of originality and of interest for its strong practical implications in different production environments.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
W2041552934
|
Handbook of Open Source Tools
|
Handbook of Open Source Tools introduces a comprehensive collection of advanced open source tools useful in developing software applications. The book contains information on more than 200 open-source tools which include software construction utilities for compilers, virtual-machines, database, graphics, high-performance computing, OpenGL, geometry, algebra, graph theory , GUIs and more. Special highlights for software construction utilities and application libraries are included. Each tool is covered in the context of a real like application development setting. This unique handbook presents a comprehensive discussion of advanced tools, a valuable asset used by most application developers and programmers; includes a special focus on Mathematical Open Source Software not available in most Open Source Software books, and introduces several tools (eg ACL2, CLIPS, CUDA, and COIN) which are not known outside of select groups, but are very powerful. Handbook of Open Source Tools is designed for application developers and programmers working with Open Source Tools. Advanced-level students concentrating on Engineering, Mathematics and Computer Science will find this reference a valuable asset as well.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Emerging enabling technologies"
]
] |
W1612808768
|
Indesent: indeterminate sentencing and imprisonment – an interdisciplinary study of the experiences of court processes and prison practices
|
In Denmark, indeterminate sentences are given to people who commit serious offences (murder, aggravated violence, sexual offenses, arson, and robbery) and who are deemed likely to reoffend due to previous offending and their mental state. They are held in prison indeterminately in order to protect the public and enable rehabilitation - a practice which is in line with the Council of Europe’s recommendations. Indeterminate sentences have one particular feature that sets them aside from all other types of imprisonment: there is no guarantee of ever being released. This uncertainty often results in severe pains for the prisoners in question. While there is a fairly rich literature on indeterminate imprisonment in the Anglo-phone countries, the last explorative study of indeterminate imprisonment in the Nordic countries was conducted over 50 years ago, hence our understanding of contemporary experiences of indeterminate confinement remains very limited. IndeSent responds to the Council of Europe’s call for more research focused on the needs of the offender in the light of the negative effects of the often long-term imprisonment. The research project will provide an in-depth examination of the experience of being indeterminately sentenced by a court and of serving an indeterminate sentence in prison. The combination of courts and prison practices is one of the most pioneering aspects of the proposed research, illustrating the connections between the wider aims and functions of the penal state and the everyday practices, experiences and interactions in prison. Usually, there is a sharp distinction between the allocation and delivery of punishment; the first happens in courts and the second in penal institutions. Using ethnographic research methods (participant observation, in-depth interviews and a Dialogue Group), IndeSent will address this gap in the scholarship by focusing on the experiences of the indeterminate sentenced in the two arenas of punishment.
|
project/european
|
[
[]
] |
[
[]
] |
3736151
|
Multiplication rate of selected potato cultivars in vitro through single node culture
|
A study was carried out in the tissue culture laboratory at the National Potato Research Centre (NPRC), Tigoni, Kenya to determine the multiplication rate of selected potato cultivars when micropropagated through single node culture. Seven potato cultivars were subcultured on solid media for three consecutive cycles (each cycle took three weeks). This was repeated twice. Data collected was the number of single-node cuttings that were generated from each node after subculturing. Generally, there were significant differences (P≤0.05) on the number of single node cuttings generated among the potato cultivars, among the subculture cycles and in the interaction between genotypes and subculture cycle.
|
publication
|
[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas",
"Bio-based innovation systems in the bioeconomy"
]
] |
W1787741158
|
Sustainable, wireless, autonomous nanocellulose-based quantitative doa biosensing platform
|
Paper-based printed electronics are new recyclable electronic devices with technical, economic and environmental advantages. Additionally, nanocellulose (NC) based printed electronics, produced mainly from wood pulp, offer better printability and performance than paper. Therefore, the integration of NC-based printed electronics and biosensors is a promising source of innovation in the biomedical industry. In GREENSENSE we propose the development of a sustainable NC-based biosensing platform for Drug-of-Abuse (DoA) analysis, that integrates high-added value printed electronic components (a new biosensor, an NFC communication system, an energy storage system and a display) with a silicon microchip to provide it with multi sensor data processing, autonomy and wireless communication and that is easy for the user to read. The main goal of the project will be the use of NC as: substrate for the printed electronics, lamination film for the encapsulation of the final device and as active component in the formulation of functional inks (conductive, electrochemical, electrolyte and dielectric). In all cases the NC surface will be functionalized to be printable, with good barrier properties and compatible with the functional inks (bioactive, conductive, dielectric, electrochemical, electrochromic and electrolyte). Pilot lines and high throughput, high precision and cost-effective S2S screen-printing and ink-jet printing techniques will be used to produce materials and components at large-scale. Two types of DoA biosensing platforms to eradicate the consume of drugs among the society will be developed: a strip-based platform (2nd generation) that will be connected to a Smartphone and a strip+reader-based platform (3rd generation) that will also include a display. The final flexible and recyclable NC-based biosensing platform will be mass producible with ultra-low power consumption and, therefore, cost-effective, sustainable and environmentally friendly.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
222263
|
Traitement par immunoglobuline sous cutanée facilitée chez les patients atteints de déficit immunitaire primitif et secondaire : l’étude FIGARO
|
L’immunoglobuline sous-cutanée facilitée (IGSCf), kit à double flacons d’Immunoglobuline G (IgG) 10 % et de hyaluronidase humaine recombinante (rHuPH20) est autorisée en Europe comme traitement de substitution pour le déficit immunitaire primitif (DIP) et le déficit immunitaire secondaire (DIS) chez les adultes, enfants et adolescents. L’objectif de l’étude FIGARO est de fournir des données de vraie vie sur l’utilisation et la tolérance de l’IGSCf chez les patients DIP et DIS. FIGARO (NCT03054181) est une étude prospective, multicentrique (n = 14), observationnelle, conduite en Europe sous les auspices de la Société européenne d’immunodéficiences (ESID). Le début de l’étude était en décembre 2016. La clôture de la base de données était en mai 2021. Les patients ayant reçu ≥ 1 administration d’IGSCf pour un DIP ou DIS et ayant fourni un consentement éclairé étaient éligibles et suivi pendant ≤ 3 ans. Les données ont été analysées par âge (population pédiatrique [< 18 a], adulte [18–64 a], et patients âgés [≥ 65 a]) et sont présentés ici jusqu’à 1 an de suivi. Un total de 156 patients étaient inclus : 15 patients pédiatriques, 120 adultes et 21 patients âgés. Des données de suivi à 1 an étaient disponibles pour 128 patients. L’IGSCf était principalement prescrite pour le DIP parmi les patients < 65 ans (population pédiatrique : 93,3 % DIP ; adultes : 87,5 % DIP),et pour le DIS parmi les patients âgées (71,4 %). Les paramètres d’administration de l’IGSCf à l’inclusion et après 1 an de suivi sont décrits dans le tableau. À l’inclusion, 75,6 % ont reçu leur IGSCf à la maison et 78,7 % en auto-administration. Les adultes étaient plus susceptibles de recevoir leur administration initiale à la maison en auto-administration (81,7 % et 86,6 % respectivement) que les patients pédiatriques (53,3 % chacun) et les patients âgés (57,1 % et 52,4 % respectivement). À 1 an, la proportion de patients recevant le traitement à domicile et l’auto-administration a augmenté à 85,5 % et 88,2 % respectivement. À chaque moment dans le temps, > 80 % des patients recevaient des perfusions toutes les 3 à 4 semaines, et le nombre médian de sites de perfusion était de 1,0. À 1 an de suivi, 21 patients (16,5 %) ont signalé des effets indésirables (EI) associés à l’IGSCf. Parmi ceux-ci, 15 avaient des effets indésirables locaux (pédiatrie [n = 1], adulte [n = 14] et patient âgé [n = 0]) et 11 avaient des effets indésirables systémiques (0, 10 et 1, respectivement). FIGARO fournit des informations sur l’utilisation réelle de l’IGSCf dans un échantillon large et non sélectionné de patients atteints de DIP et DIS, et confirme la faisabilité et la tolérance de l’IGSCf à travers un spectre d’âge. Quel que soit leur âge, la plupart des patients ont pu s’auto-administrer la dose complète d’IGSCf à domicile toutes les 3 à 4 semaines et n’ont eu besoin que d’un seul site de perfusion.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
W4282974159
|
A Review of the Construction of Particular Measures
|
The first measure one usually comes into contact with in undergraduate mathematical studies is the Lebesgue measure and seeing how it is applied to the Lebesgue integral to extend considerably the Riemann integral, it doesn’t take very much else to arouse one’s interest in the study of measures and their construction with the hope/intent of eliciting their usefulness and how they are applied to other areas of mathematics. The Caratheodory extension theorem and the Caratheodory-Hahn theorem which are invoked subsequently in the construction of some measures are stated without proof. A large class of measures exist and this paper illustrates the construction of some of these measures including the Radon measure, the Hausdorff measure, the Lebesgue-Stieltjes measure, the Lebesgue measure in R and Product measures. The material presented is standard but it provides a summary of some key points on measure theory which might prove to be useful for the undergraduate.
|
publication
|
[
[]
] |
[
[]
] |
W1983290745
|
Work function evolution of graphene oxide by utilizing hydrothermal treatment
|
In this paper, hydrothermal treatment is applied for graphene oxide (GO) reduction. Tunable work function of hydrothermal treated GO (HTGO) is facilitated by controlling hydrothermal temperature and duration time, in comparison, CVD grew graphene (CVD-G) are also prepared. Work function of GO is tuned in the range of 5.72 eV to 4.43 eV. Progressing descend of peak intensity at higher binding energy region for which belonging to oxygen-containing functional group (c.a. 286 eV to 290 eV) in C1s XPS spectra indicated controllable reduction of hydrothermal treatment. The X-ray absorption near edge structure (XANES) spectra, indicates the increased sp2 to sp3 ratio in accordance with the raise of hydrothermal temperature, consistent with the increased conductivity with increment amount of sp2 species in HTGOs.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Advanced Materials"
]
] |
W1978867436
|
La estafa en triángulo: análisis de sus elementos esenciales, la problemática en cuanto su tipificación en la legislación sustantiva penal en Ecuador y los efectos que de esta se derivan
|
This thesis project deals with various questions that arise around the called fraud triangle, that is, one in which the subject deceived and deponent, although without being the holder of certain assets, performs by deception and mistake a wrongful disposal of assets, which ultimately affects to a different subject, who is actually the owner of the affected assets. Specifically, a comparison between the traditional and fraud triangle components is done, the categorization or not of the fraud in triangle is analyzed on the law of Ecuador, the elements that must be met are analyzed and determined so that the unjust in question is constituted, and the type of relationship that should exist between the deceived-deponent and the affected assets is studied, so that it can be accepted that the former person performs the typical arrangement required by the triangular fraud. In effect, it is argued that in Ecuadorian law for completing the categorization of fraud triangle and punishing as a crime, this must be expressly stated in the criminal legal regulations in accordance with the principle of legality which implies that the criminal law is written, i.e. it must be exclusively positive law. That the criminal law is prior means that it cannot punish an act that it is not listed as a crime at the time of restraint and strict refers to the criminal law that should be exhaustive and provide certainty. So the criminal law should make a specific description of the act or omission that considers as a crime, so that there is no ambiguity that interferes with their knowledge and application; regarding the bond that should exist between the subject deceived-deponent and affected assets. We conclude that a special relationship is sufficient, in fact or in law, for settings to be considered fraud in triangle. Finally, recommendations are done in reference to the way the triangular fraud should be understood and treated in our criminal justice.
|
publication
|
[
[
"Civil Security for Society"
]
] |
[
[]
] |
W1540221882
|
Probabilistic petrophysical-properties estimation integrating statistical rock physics with seismic inversion
|
A joint estimation of petrophysical properties is proposed that combines statistical rock physics and Bayesian seismic inversion. Because elastic attributes are correlated with petrophysical variables (effective porosity, clay content, and water saturation) and this physical link is associated with uncertainties, the petrophysical-properties estimation from seismic data can be seen as a Bayesian inversion problem. The purpose of this work was to develop a strategy for estimating the probability distributions of petrophysical parameters and litho-fluid classes from seismics. Estimation of reservoir properties and the associated uncertainty was performed in three steps: linearized seismic inversion to estimate the probabilities of elastic parameters, probabilistic upscaling to include the scale-changes effect, and petrophysical inversion to estimate the probabilities of petrophysical variables andlitho-fluid classes. Rock-physics equations provide the linkbetween reservoir properties and velocities, and linearized seismic modeling connects velocities and density to seismic amplitude. A full Bayesian approach was adopted to propagate uncertainty from seismics to petrophysics in an integrated framework that takes into account different sources of uncertainty: heterogeneity of the real data, approximation of physical models, measurement errors, and scale changes. The method has been tested, as a feasibility step, on real well data and synthetic seismic data to show reliable propagation of the uncertainty through the three different steps and to compare two statistical approaches: parametric and nonparametric. Application to a real reservoir study (including data from two wells and partially stacked seismic volumes) has provided as a main result the probability densities of petrophysical properties and litho-fluid classes. It demonstrated the applicability of the proposed inversion method.
|
publication
|
[
[
"Digital, Industry and Space",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Advanced computing and big data",
"Emerging enabling technologies"
]
] |
W2168225771
|
Exercise as a regulator of hepatic nad metabolism and mitochondrial function in non-alcoholic fatty liver disease
|
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in industrialized countries, including Europe, and comprises a spectrum of disorders ranging from hepatic lipid accumulation (steatosis) to inflammation (non-alcoholic steatohepatitis, NASH) and fibrosis. Pathogenic pathways leading from hepatic steatosis to NASH are still incompletely understood resulting in a lack of approved therapeutic options besides life style changes. Physical activity is effective to prevent NAFLD progression. The mechanism of exercise action on liver mitochondrial metabolism is not clear yet. However, exercise might exert its positive effects via increasing hepatic nicotinamide adenine dinucleotide (NAD) levels. Several studies showed that the hepatic NAD metabolism is dysregulated during the development of NAFLD and that exercise has a positive effect on NAD metabolism and function of NAD dependent enzymes in skeletal muscle. The functionality of mitochondrial metabolism is highly dependent on the maintenance of the organellar NAD pool. Mitochondrial dysfunction has been implicated in the progression from steatosis to NASH. We hypothesize that a dysregulated NAD metabolism in the liver is involved in the development of hepatic mitochondrial dysfunction in NAFLD/NASH. Our overall aim is to define the impact of exercise on hepatic mitochondrial dysfunction and test whether exercise effects are mediated via restoration of NAD metabolism. We will achieve this by combining the knowledge on hepatic NAD metabolism of the fellow with the expertise in exercise mouse models and on analysis of mitochondrial function of the Supervisor. This study is one of the first to comprehensively examine the interaction between exercise, mitochondrial dysfunction as a cause of NAFLD and NAD metabolism specifically in the liver and in hepatocytes and ultimately aims to identify novel therapeutic targets for the prevention and treatment of NAFLD.
|
project/european
|
[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Health throughout the life course",
"Non-communicable and rare diseases"
]
] |
216407
|
Conséquences cardiovasculaires de l’hypothermie
|
Hypothermia, defined as body temperature equal to or inferior to 35℃ is often encountered in the intensive care patients. It can be accidental or therapeutic, in which case it plays a role in certain ischemia-reperfusion processes. Hypothermia has multiple cardiac and vascular effects including initial tachycardia followed by bradycardia; a preservation of myocardial contractility in case of mild or moderate hypothermia, and an initially stable or decreased cardiac index that decreases further during profound hypothermia; a decrease in myocardial and overall metabolic requirements with an increase in SvO2 resulting in a favorable or stable ratio of oxygen delivery/consumption despite the usual hypoxia-hypocapnia; an increase in overall vascular resistance despite a decrease in sensitivity to exogenous catecholamines; a tendency to hypovolemia essentially due to coldinduced diuresis.
|
publication
|
[
[
"Health"
]
] |
[
[
"Health throughout the life course"
]
] |
W137066757
|
Context congruency and robotic facial expressions: Do effects on human perceptions vary across culture?
|
We performed an experimental study (n=48) of the effects of context congruency on human perceptions of robotic facial expressions across cultures (Western and East Asian individuals). We found that context congruency had a significant effect on human perceptions, and that this effect varied by the emotional valence of the context and facial expression. Moreover, these effects occurred regardless of the cultural background of the participants. In short, there were predictable patterns in the effects of congruent/incongruent environmental context on perceptions of robot affect across Western and East Asian individuals. We argue that these findings fit with a dynamical systems view of social cognition as an emergent phenomenon. Taking advantage of such context effects may ease the constraints for developing culturally-specific affective cues in human-robot interaction, opening the possibility to create culture-neutral models of robots and affective interaction.
|
publication
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Artificial intelligence and robotics"
]
] |
W1966779602
|
DIGITALISATION, SUSTAINABILITY AND SECURITY FOR METAL-PRESSES
|
PURPOSE ÃÂ Â: DIGITAL TRANSITION OBJECTIVES: — INTEGRATING DIGITAL TECHNOLOGIES INTO PRODUCTION PROCESSES: FUNCTIONAL INTERVENTIONS FOR THE INTEGRATION OF DIGITAL TECHNOLOGIES IN THE PRODUCTION CYCLE OF THE COMPANY’S GOAL ÃÂ Â: GREEN TRANSITION OBJECTIVES: — INCREASE THE ENERGY EFFICIENCY OF THE PRODUCTION SYSTEM: FUNCTIONAL INTERVENTIONS TO REDUCE ENERGY CONSUMPTION OR IN ANY CASE TO LOW ENERGY CONSUMPTION, TO RATIONALISE ENERGY FLOWS AND MINIMISE ANY ENERGY WASTE, TO RECOVER OR ENHANCE THE ENERGY DISPERSAFINALITÃ ÃÂ Â: SECURITY OBJECTIVES: — INCREASE THE SAFETY OF WORKERS, CUSTOMERS/USERS AND SUPPLIERS: FUNCTIONAL INTERVENTIONS TO IMPROVE SAFETY CONDITIONS IN THE WORKPLACE, WHICH REDUCE THE RISK OF ACCIDENTS, INCLUDING BY PROVIDING SOLUTIONS TO CONTAIN THE EPIDEMIOLOGICAL EMERGENCY FROM COVID-19
|
project/regional
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Buildings and industrial facilities in energy transition",
"Energy systems and grids"
]
] |
Q4869095
|
On the ecological scenario of the first hominin dispersal out of Africa
|
The archaeopaleontological site of Dmanisi in Georgia, dated to ∼1.8 Ma, provides evidence on the first hominin dispersal out of Africa, while the sites of Barranco León and Fuente Nueva-3 in Spain, dated to ∼1.4 Ma, record the earliest hominin settlements in Europe. However, a number of issues related to the dispersal route, the climatic conditions and the ecological scenario of this dispersal event are subject to debate. In a recent paper in L’anthropologie, Agustí and Lordkipanidze (2019) proposed an alternative scenario for the arrival of hominins in the Caucasus, which they conceived as a forest refugium area during the Early Pleistocene, and discarded that their dispersal coincided with that of other members of the Ethiopian and Asian faunas, like the sabertooth Megantereon whitei or the giant hyena Pachycrocuta brevirostris. Our review of these issues suggests that: (i) the elongated sabers and reduced postcanine teeth of African M. whitei limited the ability of this predator to process the prey carcass, which resulted in scavengeable resources for the Dmanisi hominins; (ii) the mass estimate in excess of 100 kg obtained for the trochlear perimeter of the distal humerus of the hyena from Dmanisi shows that it can be confidently ascribed to the genus Pachycrocuta; (iii) the postcranial anatomy of the Dmanisi hominins was not advantageous for scavenging tree-stored prey; (iv) the laterally flattened upper canines of M. whitei could not withstand the loads that would result from climbing a prey carcass into a tree; (v) paleobotanical analyses suggest a temperate grassland ecosystem in Dmanisi, not dominant forest conditions, with enhanced aridity in the level of hominin occupation; (vi) similarly, the low frequency of arboreal pollen in the Levantine Corridor at ∼1.8 Ma points to more arid conditions than today in this area; (vii) many archaeopaleontological sites of the Rift Valley and its extension towards the Red Sea, the Levant and the Caucasus show evidence of tectonic, volcanic and/or hydrothermal events; and (viii) the delay of 400 ka in the arrival of hominins in Western Europe did not result from a lower availability of scavengeable resources. Le site archéopaléontologique de Dmanisi en Géorgie, daté de ∼1,8 Ma, fournit des preuves de la première dispersion d’hominidés hors d’Afrique, tandis que les sites de Barranco León et de Fuente Nueva-3 en Espagne, datés de ∼1,4 Ma, témoignent des premières implantations en Europe. Cependant, un certain nombre de questions liées à l’itinéraire de dispersion, aux conditions climatiques et au scénario écologique de cet événement de dispersion sont sujettes à débat. Dans un article récent de L’anthropologie, Agustí et Lordkipanidze (2019) proposent un scénario alternatif pour l’arrivée des hominidés dans le Caucase, qu’ils conçoivent comme une zone forestière de refuge au Pléistocène inférieur, et écartent que leur dispersion soit liée à celle d’autres membres des faunes éthiopienne et asiatique, comme le Megantereon whitei à dents de sabre ou l’hyène géante Pachycrocuta brevirostris. Notre examen de ces questions le suggère : (i) les dents de sabres allongées et les dents postcanines réduites du M. whitei africain ont limité la capacité de ce prédateur à traiter la carcasse de sa proie, ce qui a permis aux hominidés de Dmanisi de disposer de ressources plus importantes ; (ii) l’estimation de la masse supérieure à 100 kg obtenue pour le périmètre trochléaire de l’humérus distal de la hyène de Dmanisi montre qu’elle peut être attribuée avec certitude au genre Pachycrocuta ; (iii) l’anatomie post-crânienne des hominines de Dmanisi n’était pas avantageuse pour la récupération des proies stockées dans les arbres ; (iv) les canines supérieures allongées et latéralement aplaties de M. whitei ne pouvaient pas supporter les charges qui résulteraient de la montée d’une carcasse dans un arbre ; (v) les analyses paléobotaniques suggèrent un écosystème de prairie tempérée à Dmanisi, et non des conditions forestières dominantes, avec une aridité accrue du niveau d’occupation des hominines ; (vi) de même, la faible fréquence du pollen arboricole dans le corridor levantin à ∼1,8 Ma indique des conditions plus arides qu’aujourd’hui dans cette région ; (vii) de nombreux sites archéopaléontologiques de la vallée du Rift et de son extension vers la mer Rouge, le Levant et le Caucase montrent des preuves d’événements tectoniques, volcaniques et/ou hydrothermaux ; et (viii) le retard de 400 ka dans l’arrivée des hominines en Europe occidentale ne résulte pas d’une moindre disponibilité des ressources exploitables.
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publication
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[
[
"Culture, Creativity and Inclusive Society",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
W4206926665
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Implantable Tissue Ischemia Sensor
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An implantable ischemia detection system in which a white LED (105) produces a continuous, visible, broadband light illuminating a target site (125). Light backscattered by the target is collected by a sensor (155), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (167). Power is provided by an internal power source (179). The entire implantable device is encapsulated by a biocompatible shell (102) to add long-term safety with regard to implantation.
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patent
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[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
US 85839610 A
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SUCTION COMPRESS
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The invention relates to a suction compress comprising a flexible body with a rough outer surface having two thin faces of identical geometric configuration. The ventral face includes a plurality of holes and the outer surface of the dorsal face includes a flexible handle. The two faces define therebetween a cavity provided straight raised patterns directed towards a predetermined point on the periphery, whereat a coupling is located along the same axis of the structure, said coupling being connected to a vacuum source in order to extract liquids or to a liquid source in order to irrigate said liquids in a controlled manner through the holes in the ventral surface. The suction compress provides the advantages of a suction cannula as well as those of a compress or gauze, while minimising the disadvantages associated with said devices taken separately.
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patent
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[
[
"Health"
]
] |
[
[
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
MX 2010000038 W
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Characterization of antibiotic-resistant and potentially pathogenic <i>Escherichia coli</i> from soil fertilized with litter of broiler chickens fed antimicrobial-supplemented diets
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The objective of this study was to characterize antimicrobial resistance and virulence determinants of Escherichia coli from soil amended with litter from 36-day-old broiler chickens ( Gallus gallus domesticus ) fed with diets supplemented with a variety of antimicrobial agents. Soil samples were collected from plots before and periodically after litter application in August to measure E. coli numbers. A total of 295 E. coli were isolated from fertilized soil samples between August and March. Antibiotic susceptibility was determined by Sensititre, and polymerase chain reaction was performed to detect the presence of resistance and virulence genes. The results confirmed that E. coli survived and could be quantified by direct plate count for at least 7 months in soil following litter application in August. The effects of feed supplementation were observed on E. coli numbers in November and January. Among the 295 E. coli, the highest antibiotic resistance level was observed against tetracycline and β-lactams associated mainly with the resistance genes tetB and bla CMY-2 , respectively. Significant treatment effects were observed for phylogenetic groups, antibiotic resistance profiles, and virulence gene frequencies. Serotyping, phylogenetic grouping, and pulsed-field gel electrophoresis confirmed that multiple-antibiotic-resistant and potentially pathogenic E. coli can survive in soil fertilized with litter for several months regardless of antimicrobials used in the feed.
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publication
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[
[
"Health",
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Environmental and social health determinants",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W1988183895
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ILLUMINATED ASSEMBLY FOR A SWITCH/OUTLET
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An illuminating apparatus for a wall switch (20) or outlet (2) that has a pair of terminals (4, 5) across which an electric potential is available, including an electroluminescent lamp plate (17) having first and second electrode deposits (14, 15) on a surface thereof, and a contact plate (12) disposed between the wall switch (20) or outlet (2) and the electroluminescent lamp plate (17) and a back surface facing the switch (20) or outlet (2), the contact plate (12) having first and second conductors (3, 6), each of which pass through the contact plate (12) and one of the terminals (5), and the second conductor (6) contacting the second electrode deposit (15) and the other of the terminals (4).
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
CA 2252831 A
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Conservation agriculture for enhancing crop productivity and resource-use efficiency
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At global scale much emphasis has been given on conservation agriculture. During the last four decades intensive agriculture has been practiced by using excessive chemical fertilizers without taking care of organic manures. This leads to decline in production and profitability of farmers’ income. Rampant decline in resources forced many countries at global scale to shift towards conservation agriculture. Globally, conservation agriculture has been adopted over 106 million ha area. USA, Australia, Canada, Brazil and Argentina are leading countries. The main aim of this technology is minimal disturbance of soil, no tillage and retention of crop residue on soil surface with reduced traffic. Use of cover crops and green manuring should be included in cropping cycle. Adoption of conservation agriculture practices will lead to enhanced and sustained crop production, soil quality and sound environment which is required for sustainable agriculture.
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publication
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[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas",
"Circular systems",
"Environmental observation"
]
] |
W2267118901
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A Trajetória da Normatização do Turismo em Terras Indígenas: práticas do Estado e dos povos indígenas
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O turismo envolve uma complexidade de relações nos territórios onde ocorre. A visitação turística já está presente em terras e/ou territórios dos povos indígenas no Brasil há algumas décadas, envolvendo uma complexidade de relações que entrelaçam estes povos e o Estado. Este artigo teve o objetivo de contextualizar brevemente o processo histórico de relações entre o Estado, os povos indígenas e as iniciativas de visitação turística, com um enfoque na elaboração e início de implantação da normativa desta visitação e seus potenciais impactos. Nesse sentido, foi realizada uma pesquisa de abordagem qualitativa, por meio de estudo bibliográfico e documental e descrição analítica com foco nas relações entre os povos indígenas e o Estado em relação ao turismo. Identificou-se na trajetória do turismo em terras e/ou territórios dos povos indígenas, propostas de rupturas das formas de relações entre os povos indígenas, Estado e outras sociedades, evidenciando a necessidade do diálogo e a coexistência de diferentes formas de gestão e práticas do turismo.
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publication
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[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
W4281863536
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Democratizing a cyber security toolkit for smes and mes
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CyberKit4SME aims to democratize a kit of cyber security tools and methods enabling SMEs/MEs to: Increase awareness of cybersecurity risks, vulnerabilities and attacks; Monitor and forecast risks; Manage risks using organisational, human and technical security measures with greater confidence; and Collaborate and share information in a collective security and data protection effort.
Tools developed in the project are: Semi-automated ISO 27005 threat identification and risk mitigation analysis, using a knowledge base of technical and human/organisational risk factors; Encryption and isolation tools to protect data being stored, processed or exchanged; Security information and event management, using multiple data sources for threat detection and diagnosis, Blockchain tools for SMEs/MEs to share intelligence and incident reports with supply chain partners and with CERTs.
CyberKit4SME will make its tools cheaper and more usable by SME/ME, by 1) Exploiting synergies between tools in the kit to simplify the use of each; 2) Sharing information to increase the data available for threat detection and diagnosis at each SME/ME; 3) Embedding intelligence (e.g. machine reasoning and data analytics), to fill gaps in inputs and automate tasks such as risk analysis and security configuration.
The project will also use its tools and cyber range demos to train SMEs/MEs to identify their top threats and recognise and address them with greater confidence. Results will be validated by SME/ME in four critical sectors: Finance, Health Care, Energy and Transport. Outcomes include reducing the time/cost of cyber security awareness and protection, simplifying meeting and demonstrating compliance with NIS Directive and GDPR, protecting distributed assets from cloud services to edge devices, and engaging in secure supply chains with larger organisations. The project will also collaborate with related research projects and disseminate widely in the scientific community and in SME networks.
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project/european
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[
[
"Civil Security for Society"
]
] |
[
[
"Cybersecurity",
"Protection and security"
]
] |
3738134
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SYSTEMS, APPARATUSES AND METHODS FOR STUDYING MODERATE WATERFLOODING IN FRACTURED TIGHT OIL RESERVOIRS
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Systems, apparatuses and methods for studying moderate waterflooding in fractured tight oil reservoirs are described herein. The systems include an apparatus housing a rock plate sample including crude oil from a fractured tight oil reservoir. The apparatus includes a body housing the rock plate sample having a first end having an injection port and a second end having a production port. The system also includes a detector positioned along the rock plate sample to receive one or more signals from the fluid and/or the crude oil along the rock plate sample, a data acquisition system communicatively coupled to the detector to receive the one or more signals from the detector and convert the one or more signals into a digital signal, and a computing device communicatively coupled to the data acquisition system to receive the digital signal from the data acquisition system and determine a position of the fluid and/or the crude oil along the crude oil sample in real-time.
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patent
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[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Energy supply",
"Energy systems and grids"
]
] |
CA 3037513 A
|
New methods for analyzing serological data with applications to influenza surveillance
|
For decades, the hemagglutination-inhibition (HI) assay has been used in epidemiological and basic biological studies of influenza viruses. The mechanistic basis of the assay results (called titers) is not well understood. The first part of this document describes a biophysical model of HI that illuminates the mechanistic basis of and provides the theoretical motivation for new ways of interpreting titers. The biophysical model is applicable to other serological assays; this fact is illustrated using the neutralization assay. The second part of the document describes some new ways of interpreting titers, which involve, among other methods, singular value decomposition and probabilistic multidimensional scaling. The third part of the document discusses biological and mathematical issues related to the determination of the effective dimensionality of titers, and describes an algorithm for recovering unavailable titers.
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publication
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[
[
"Health"
]
] |
[
[
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W1514653749
|
METHOD OF ATTACHING SIDING BOARDS AND SIDING BOARD ATTACHMENT STRUCTURE
|
A siding board attachment structure comprising a number of suspenders each having a hook portion and fixed to a building frame, and siding boards each provided on the back surface thereof with an engaging groove which is engaged with the hook portion of each of the suspenders, whereby the siding boards are maintained in a stably suspended state. The siding boards of neighboring stages can be suitably spaced apart to such an extent that sidewall surfaces of upper and lower siding boards are made visible.
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patent
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Circular systems",
"Manufacturing technologies"
]
] |
CA 2279048 A
|
Thermodynamic nature of the0–πquantum transition in superconductor/ferromagnet/superconductor trilayers
|
In structures made up of alternating superconducting and ferromagnet layers (S/F/S heterostructures), it is known that the macroscopic quantum wavefunction of the ground state changes its phase difference across the F--layer from 0 to PI under certain temperature and geometrical conditions, whence the name "0-PI" for this crossover. We present here a joint experimental and theoretical demonstration that the "0-PI" is a true thermodynamic phase transition: microwave measurements of the temperature dependence of the London penetration depth in Nb/Pd_0.84Ni_0.16/Nb trilayers reveal a sudden, unusual decrease of the density of the superconducting condensate (square modulus of the macroscopic quantum wavefunction) with decreasing temperature, which is predicted by the theory here developed as a transition from the 0- to the PI-state. Our result for the jump of the amplitude of the order parameter is the first thermodynamic manifestation of such temperature-driven quantum transition.
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publication
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials"
]
] |
W1968978261
|
Feasibility assessment of a cloud application platform for rational drug design using high throughput molecular dynamics
|
The pharmaceutical industry’s increasing spending on R&D is not translating into new and better drugs at the pace required to maintain competitiveness. In-silico computational methods are beginning to gain traction in the progress towards more rational drug discovery workflows. Among the methods available, molecular dynamics (MD) provides the most accurate and useful description of molecular interactions, but the current state of the art has both a high degree of unnecessary technical complexity, and is computationally expensive.
Together, these two factors have produced a high barrier to entry that substantially limits research productivity.Acellera looks to address these issues by proposing a cloud application platform for high-throughput MD (HTMD) simulations. This computational platform combines proprietary simulation technology - optimized for speed and simulation throughput – and user-friendly interfaces in a cloud environment to provide a novel resource for drug candidate identification. HTMD, which allows understanding with an unprecedented degree of resolution and accuracy how drugs interact with their biological targets, can significantly reduce the cost of pre-clinical research (PCR) by virtualizing key steps.
It is currently estimated that pharmaceutical companies invest approximately 1000M Euro per approved drug. As a global leader in the development of technology for high-throughput molecular dynamics, Acellera is uniquely positioned to bring this disruptive computational technology to the market. The HTMD platform is ready for prototyping in an operational environment (TRL 6).
Acellera proposes a Phase 1 SME Instrument to support the execution of a feasibility study into the market viability of the HTMD solution for pre-clinical research. Results of the study will be used to inform preparations for a larger-scale demonstration in Phase 2 and for the subsequent market launch.
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project/european
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[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
176112
|
Investigation of nonlinear stimulated emission in optically excited dielectrics
|
The nonlinear stimulated emission of ultraviolet light in a piece of optically excited – and thus metalized – glass that usually absorbs light is counterintuitive to what has been known for many decades about light-material interaction. However, this is exactly what was recently experimentally observed for the first time. Although a preliminary explanation and model describing the effect of laser amplification in excited dielectrics (LADIE) exists, a manifold of questions about fundamental processes like the universality, the potential of nonlinear light amplification and how giant-band-gap-renormalization in dielectrics works remain unanswered. In this project, a thorough investigation of the novel phenomenon and the associated rare nonlinear stimulated emission will be initiated. On the one hand, this study is based on femtosecond spectroscopy, deploying pump-probe experiments, utilizing light-conversion and pulse-shaping techniques that will be applied to a large variety of custom-made samples. On the other hand, the experimental studies will be complemented by advanced theoretical modelling of the material excitation that will be extended towards incorporating a proper description of the new mechanisms. The investigation of the LADIE effect will most likely open up an entirely new scientific field with many new surprises in store and the potential for novel derived applications. Its perspective is a revolution in laser technology, building high power nonlinear laser amplifiers in a huge variety of band-gap materials, which has a clear interdisciplinary aspect to semiconductor and optoelectronic research (i.e. telecommunication hardware), biophysics (cell surgery, nonlinear microscopy) and nonlinear optics in general.
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project/european
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Advanced Materials"
]
] |
996480
|
Catalysis in Biodiesel Synthesis: Challenges and Future Perspectives
|
The necessity to search for fossil fuel alternative is getting more critical with the increasing fossil fuel price and also its limited supply. The use of mineral diesel for transport sector is unfeasible as it is nonrenewable and emits greenhouse gases to the atmosphere during combustion, particularly carbon dioxide which can lead to global warming phenomena. Biodiesel is a type of biofuel that can be produced using renewable resources such as biomass. It can be produced from oils and fats through transesterification process. The presence of catalyst is important to ensure that the reaction can progress at shorter time and produce high biodiesel yield. Numerous catalysts have been used to assist the transesterification process. They include homogeneous and heterogeneous catalysts and can be further divided into acid and base nature. The catalysis in biodiesel production is progressing at faster rate in order to find a catalyst that is more practical for larger production scale. Ionic liquids and ionic solids are among new catalysts introduced with aim to improve the efficiency of the process. This chapter focused on the benefits and drawbacks of different catalysts for biodiesel synthesis. The applications of novel processes for more sustainable and enhanced biodiesel production are also discussed.KeywordsBiodieselCatalystHomogeneousHeterogeneousNovel process
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publication
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[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Clean, safe and accessible transport and mobility",
"Energy supply",
"Energy systems and grids"
]
] |
W47345582
|
Conodontos y episodios carbonatados en el Silúrico de la Cadena Hercínica meridional y del Dominio Sahariano
|
Se han reunido y evaluado los datos (publicados e inéditos) sobre los conodontos silúricos en una región que se extiende desde las Ardenas hasta el Sahara occidental y central. Su revisión taxonómica ha pemitido la identificación de 63 especies y subespecies, que han sido referidas a una biozonación útil. El análisis de los aspectos lito y bioestratigráficos de cuarenta secciones sintéticas de este ambito pone en evidencia asociaciones de faunas características y su relación con la dinámica sedimentaria. El Sistema Silúrico, en la region investigada, presenta dos litofacies mayores consistentes en, pelitas que gradan de manera heterócrona a (1) facies siliciclásticas groseras, o bien a (2) calizas de cefalópodos de rampa distal ("facies mediterranea") o a calizas bioclásticas en áreas marginales. Los datos proporcionados por los conodontos en los materiales carbonatados, contrastados con la información ofrecida por graptolitos, han permitido reconocer, con caracter preliminar, la existencia de cuatro episodios carbonatados, cuya edad esta indicada por las Zonas de conodontos. El primer episodio se registra en el Llandovery, próximo al tránsito Rhuddaniense-Aeroniense y tiene un caracter local. el segundo se inicia en el Llandovery superior-Wenlock inferior, el tercero se instala desde el Wenlock mas alto-Ludlow y el cuarto en el Prídoli, correspondiendo los dos últimos a la generalización de los intervalos condensados carbonatados y que en las áreas de mayor influjo clástico estan representados por determinados horizontes de profundización.
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publication
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Culture, cultural heritage and creativity"
]
] |
W4214843393
|
Full-Value chain optimised climate user-centric services for southern africa: focus-africa
|
The central objective of FOCUS-Africa is to develop sustainable tailored climate services in the Southern African Development Community (SADC) region for four sectors: agriculture and food security, water, energy and infrastructure. The proposed co-production amongst end-users, climate scientists and sectoral service providers will ensure that the full value chain for the delivery of the climate services is effectively realised. This will be demonstrated by piloting eight case studies in six countries involving a wide range of end-uses to illustrate how the application of new climate forecasts, projections, resources from Copernicus, GFCS and other relevant products can maximise socio-economic benefits in the Southern Africa region and potentially in the whole of Africa.
An innovative aspect of FOCUS-Africa is to address the recurring sustainability and exploitation challenge of climate services in Africa. To achieve this, it will assess dynamically the socio-economic value of the proposed services during the development of the prototypes to better adapt pilot products to the local situation. End-users and service providers will be fully involved in the definition of the associated exploitation strategies using the innovative Flourishing Business Canvas to design business models that are socially beneficial, gender-sensitive, environmentally regenerative and financially viable. This approach will ensure that each of the co-designed climate product can be operationalised through WMO operational infrastructure (e.g. ECMWF, Regional Climate Centres and National Meteorological and Hydrological Services) in support of sustained country level service delivery on regional and global scales.
Ultimately, FOCUS-Africa climate services are expected to become a fundamental part of sectorial adaptation strategies at different levels (from local to national and regional) and contribute to the implementation of Paris Agreement and the Sustainable Development Goals
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project/european
|
[
[
"Climate, Energy and Mobility"
]
] |
[
[
"Climate science and solutions",
"Communities and cities",
"Energy supply"
]
] |
3731659
|
Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease
|
INTRODUCTION: Exclusive or associated lesions in various structures of the autonomic nervous system occur in the chronic forms of Chagas disease. In the indeterminate form, the lesions are absent or mild, whereas in the exclusive or combined heart and digestive disease forms, they are often more pronounced. Depending on their severity these lesions can result mainly in cardiac parasympathetic dysfunction but also in sympathetic dysfunction of variable degrees. Despite the key autonomic effect on cardiovascular functioning, the pathophysiological and clinical significance of the cardiac autonomic dysfunction in Chagas disease remains unknown. METHODS: Review of data on the cardiac autonomic dysfunction in Chagas disease and their potential consequences, and considerations supporting the possible relationship between this disturbance and general or cardiovascular clinical and functional adverse outcomes. RESULTS: We hypothesise that possible consequences that cardiac dysautonomia might variably occasion or predispose in Chagas disease include: transient or sustained arrhythmias, sudden cardiac death, adverse overall and cardiovascular prognosis with enhanced morbidity and mortality, an inability of the cardiovascular system to adjust to functional demands and/or respond to internal or external stimuli by adjusting heart rate and other hemodynamic variables, and immunomodulatory and cognitive disturbances. CONCLUSIONS: Impaired cardiac autonomic modulation in Chagas disease might not be a mere epiphenomenon without significance. Indirect evidences point for a likely important role of this alteration as a primary predisposing or triggering cause or mediator favouring the development of subtle or evident secondary cardiovascular functional disturbances and clinical consequences, and influencing adverse outcomes.
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publication
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[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W2088361430
|
Atomistic Models of Nanosystems
|
Nanoscopic systems contain, in essence, a finite number of atoms. Description of nanosystems with first principles methods of quantum mechanics is still a cumbersome process, hence simpler models are rather used in the process of modeling. In this communication we analyze atomistic approaches like the empirical tight-binding (ETB) method that can be used with many flavors of sophistication to calculate both electronic structure and transport properties of nanosystems of various sizes ranging from tens and hundreds to millions of atoms. In contrast, the ab-initio methods deal with smaller systems, yet they provide reliable information, like equilibrium geometry and charge distribution, which are not fully captured by ETB methods. Several examples of relevant nanosystems that uses either ETB or ab-initio methods are provided.
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publication
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[
[
"Digital, Industry and Space"
]
] |
[
[
"Emerging enabling technologies",
"Advanced Materials"
]
] |
W2998950903
|
Integrated and Interoperable Maritime Transit Management System
|
ICT technologies (including interoperable web-platforms and emerging technologies such as RFIDs) have proven of great assistance to tackle MED/EU port challenges regarding logistics and communication systems. Their customized use in different ports has limited their effect. Hence, it is essential to develop a communication framework between ports, administrations, logistic activities areas, relevant operators and commercial stakeholders. Towards this direction, INTE-TRANSIT aims in a better organization of MED ports and their logistic activities areas and establish a cooperation framework between relevant stakeholders in MED countries for best practice exchange, cooperation and personnel training. More specifically, INTE-TRANSIT will be focusing on the following: - Strengthen communication links between i) ports and relevant authorities across the MED Basin, ii) all relevant actors in the maritime transfers and iii) ports and their logistic activities areas, through the use of modern ICT technologies that will be used to enhance information management systems - Define an integrated management model involving public and private organizations (in ports and their logistic activities areas) and devise a common and harmonized MED processes map and indicators. This will lead to more efficient ports interoperability and a relevant improvement of the flow of goods, cargo traceability, visibility and transparency - Provide a training framework for ports and logistic areas personnel (administrative/managerial and labour workers). Training sessions will be provided towards the Ports, Port Authorities, Logistic Activities Areas Managers and Logistics partners, focusing on logistic/security frameworks, transportation tracking mechanisms, ports' telematics infrastructures as well as modern ICT technologies towards improved communications/cooperations - Execute 5 pilot projects to demonstrate improvement of logistic systems and port operations using the proposed new INTE-TRANSIT technologies. Two different sets of pilots will be executed to the involved ports: 1. Application of ICT technologies on container/cargo tracking/monitoring 2. Electronic tool/platform to implement the management model designed including the scoreboard associated - Develop/execute a best practice exchange framework for exchange of experience within the project as a sustainable means of communication beyond the project. Exchange visits will be focusing on knowledge gaining and awareness development on port modules (logistic organization, enhanced goods traceability, improved quality assurance) - Develop information awareness activities regarding dissemination towards results spreading to local and regional authorities and related target groups including project website, leaflets and poster, logo and the organization of 2 workshops.
|
project/regional
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Key digital technologies",
"Emerging enabling technologies",
"Circular systems",
"Manufacturing technologies"
]
] |
interreg_1798
|
10,000-PSI MULTILATERAL FRACKING SYSTEM WITH LARGE INTERNAL DIAMETERS FOR UNCONVENTIONAL MARKET
|
Provided is a frac window system, a well system, and a wellbore stimulation method. The frac window system, in one aspect, includes an elongated tubular having a first end and a second end with an opening defined in a wall of the elongated tubular between the first end and the second end, the wall having an inner surface and an outer surface, wherein the opening in the wall is configured to align with a window of a wellbore casing. The frac window system, according to this aspect, may further include a polished bore receptacle coupled to the first end of the elongated tubular, the polished bore receptacle having an inside diameter (ID1) sufficient to engage with a high-pressure frac string.
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Net-zero and less polluting Industries",
"Advanced Materials",
"Manufacturing technologies"
]
] |
US 2022/0032447 W
|
Recording tape cartridge
|
A recording tape cartridge (10) can prevent release of rotation locking of a reel (40) with respect to a case accompanying dropping of the recording tape cartridge. The tape recording cartridge is configured to rotatably accommodate within a case a reel that has magnetic tape wound on a reel hub. Within the reel hub, external teeth of a brake gear (82), of a brake member (80) that is supported so as to be non-rotatable with respect to the case, mesh with an engaged gear (54) having internal teeth, preventing rotation of the reel with respect to the case. Lock portions (93) of lock members (90) are inserted between the reel positioned biased to a bottom panel side by a compression coil spring (78), and a top panel, thereby preventing movement of the reel with respect to the case in the reel axial direction.
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
EP 09010039 A
|
BIODEGRADABLE APPARATUS AND METHOD FOR CLOSURE OF TROCAR DEFECTS
|
A biodegradable device for providing scaffolding for a trocar defect to promote healing. The device consists of an upper and lower scaffold, offset by a connector. The device is arranged so the distance between the lower surface of the upper scaffolding and upper surface of the lower scaffolding holds the fascia around the trocar defect while promoting tissue growth. The surfaces of the scaffolding in contact with the trocar defect are textured to maximize adherence to tissue.
|
patent
|
[
[
"Health"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
US 201414210230 A
|
Localized application of phosphorus and ammonium improves growth of maize seedlings by stimulating root proliferation and rhizosphere acidification
|
Abstract Root growth of many plant species can be stimulated by localized supply of nutrients such as nitrate, ammonium and phosphorus (P). The ammonium supply can cause rhizosphere acidification by inducing proton release from roots, but little information is available about ammonium and P interaction in improving nutrient use and plant growth through modifying rhizosphere processes in the field. In the present study, maize was grown on a calcareous soil (pH 8.1) in an intensive farming system in North China. To test the hypothesis that localized application of P and ammonium can improve nutrient uptake and plant growth through ammonium-induced rhizosphere acidification, the 2-year field experiment was conducted with the following treatments (N supply as ammonium): localized P application with N broadcast (N B P L ), localized application of both P and N (N L P L ), or both N and P broadcast (N B P B ). Localized supply of P plus ammonium significantly increased chlorophyll content and leaf area, leading to increased dry weight of shoots at early growth stages. The leaf expansion rate was 20–50% higher, the total root length 23–30% greater, and the plant growth rate 18–77% greater in N L P L than N B P B or N B P L treatments at early growth stages. The root-length density at the depth of 0–15 cm was greater in N L P L than N B P L or N B P B , with a greater proportion of fine roots (diameter L P L . Localized supply of P plus ammonium markedly modified rhizosphere processes by stimulating root proliferation (especially of fine roots) and by ammonium-induced rhizosphere acidification, thus significantly increasing acquisition of N and P by plants. Localized application of P combined with addition of ammonium significantly decreased rhizosphere pH (by 3 pH units) in the fertilized zone compared with the bulk soil. The results indicate that localized application of P combined with ammonium can significantly improve maize growth and nutrient use at the early stages by stimulating root proliferation and rhizosphere acidification, suggesting that modifying rhizosphere processes in the field may be an effective management strategy for improving nutrient use efficiency and plant growth.
|
publication
|
[
[
"Food, Bioeconomy, Natural Resources, Agriculture and Environment"
]
] |
[
[
"Agriculture, forestry and rural areas",
"Circular systems",
"Bio-based innovation systems in the bioeconomy",
"Environmental observation"
]
] |
W2013022091
|
The commercial exploitation of mentorship programme outcome intelligence in the global corporate and university market.
|
The MentorPitch platform www.mentorpitch.com is highly disruptive in a global mentoring context. It is the first platform to automate the management and measurement of large scale mentoring programmes. MentorPitch measures the outcomes of mentoring programmes in a corporate and education environment. MentorPitch is a Software as a Service (SAAS) cloud-based business. The platform automates the management and measurement of mentorship programmes, thereby reducing the administration time of managing a programme. It is impossible for humans to manually manage and measure the outcomes of large scale mentorships that occur in a mentoring programme. Corporate and university mentoring programme managers face one common problem – how to manually manage a mentoring programme and capture the outcomes of all the mentorships in a specific programme.
Our objectives for this project are:
1) To commercially validate the outcome intelligence for university student-alumni mentoring programmes and workplace (multinational/corporate) mentoring programmes. We will do so by engaging closely with our current customers (Dublin City University, Transterra Media) and pipeline customers (University of Warwick, INSEAD, HEC Paris, Harvard Business School and corporate mentoring customers) to develop and capture outcomes using our in-house developed technology for large scale mentorship programmes.
2) The mentor-mentee matching algorithm (based on common skills areas, skills to develop, work experience, education, location and availability), will be developed further and tested to take into account the outcomes of previous mentorships.
3) Prepare a complete Phase 2 business and commercialisation plan, suitable for an SME-Instrument Phase 2 application, including a localisation plan. In phase 2 we plan to localise the content and mobile applications for all key European and international markets, including France, Germany, Italy, Spain, Netherlands, US, Japan and China.
|
project/european
|
[
[
"Culture, Creativity and Inclusive Society",
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Artificial intelligence and robotics",
"Emerging enabling technologies"
]
] |
175168
|
Renforcement de la compétitivité de Sato d.o.o. par l’investissement dans les nouvelles technologies d’impression d’étiquettes
|
Accroître la compétitivité du secteur de la production de chaussures en Croatie et dans l’UE. Développer les capacités existantes et accroître la production par l’acquisition de nouvelles machines de fabrication.
|
project/regional
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Manufacturing technologies"
]
] |
Q2729078
|
Integrated solar heating and cooling unit based on a novel zeolite chiller and heat pump
|
The overall objective of this project is to develop a new advanced solar cooling and heating product, using advanced heat
exchanger technology and integrating a heat pump for covering peak demand. This new product is based on the further
improvement and integration of the products already commercialized by Fahren and Akotec. It uses synergies between the
technologies of thermal chillers (heat to cooling technology) and heat pump (electricity to cooling technology) and combines
know-how on design and manufacturing of adsorption chillers and solar thermal collectors in Germany, with the know-how in
heat pump and dry cooling systems of CNR and NTUA.
The main innovation of the project is the adsorption chiller unit based on Fahren’s patented zeolite coating technology,
reducing the unit’s volume and cost by about two times. This new product is expected to become cost-effective and with high
flexibility for providing both cooling (during summer) and heating (during winter) from the same compact product, being more
competitive than existing mainstream solution, reducing energy costs of the end-users and leading to short ROI. The main
target market is the heating, ventilation and air-conditioning (HVAC) market, with the ambition to become front-runners and
provide the first cost-effective product, with low maintenance requirements. The target cost is to reach just 2000 €/kW (with
solar field and cooling, heating and thermal storage included) and secure a short return on investment.
The new product will be commercialized by a new joint venture established between Fahren and Akotec with Diadikasia
being a strategic partner for promotion and sales in south Europe. The initial target markets are in Greece, Italy and
Germany, while further expansion steps will follow once sales increase.
|
project/european
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Buildings and industrial facilities in energy transition",
"Energy storage",
"Energy supply"
]
] |
221220
|
Transforming transport
|
Big Data will have a profound economic and societal impact in the mobility and logistics sector, which is one of the most-used industries in the world contributing to approximately 15% of GDP. Big Data is expected to lead to 500 billion USD in value worldwide in the form of time and fuel savings, and savings of 380 megatons CO2 in mobility and logistics. With freight transport activities projected to increase by 40% in 2030, transforming the current mobility and logistics processes to become significantly more efficient, will have a profound impact. A 10% efficiency improvement may lead to EU cost savings of 100 BEUR. Despite these promises, interestingly only 19 % of EU mobility and logistics companies employ Big Data solutions as part of value creation and business processes.
The TransformingTransport project will demonstrate, in a realistic, measurable, and replicable way the transformations that Big Data will bring to the mobility and logistics market. To this end, TransformingTransport, validates the technical and economic viability of Big Data to reshape transport processes and services to significantly increase operational efficiency, deliver improved customer experience, and foster new business models. TransformingTransport will address seven pilot domains of major importance for the mobility and logistics sector in Europe: (1) Smart High-ways, (2) Sustainable Vehicle Fleets, (3) Proactive Rail Infrastructures, (4) Ports as Intelligent Logistics Hubs, (5) Efficient Air Transport, (6) Multi-modal Urban Mobility, (7) Dynamic Supply Chains. The TransformingTransport consortium combines knowledge and solutions of major European ICT and Big Data technology providers together with the competence and experience of key European industry players in the mobility and logistics domain.
|
project/european
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Clean, safe and accessible transport and mobility",
"Industrial competitiveness in transport",
"Smart mobility"
]
] |
216623
|
Analisis Indeks Pembangunan Manusia Pada 5 Wilayah Hasil Pemekaran Di Jawa Barat
|
The purpose of this study is to examine the human development index of the five expansion regions in West Java such as Cimahi, Depok, Banjar, Bekasi and Tasikmalaya. The evaluation of the five cities is using data panel regression to the dependent variable of human development index. The study is tested with using data on 2003 to 2012. The findings of this study are GDP per capita and labor has a significant influence on Human Development Index. The policy of expansion region in 5 cities have already accomodated by indicators of Human Development Index which has increased due to the increasing in GDP per capita and the level of employment. This study is expected to develop some of other variables for the expansion of regional policy in particularly for economic development.
|
publication
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Social and economic transformations"
]
] |
W2205142746
|
Mechanical control of biological function
|
Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the nanometre to the metre scale. We propose to address this challenge by building an interdisciplinary research community with the aim of understanding and controlling cellular mechanics from the molecular to the organism scale. At the nanometric molecular level, we will develop cellular microenvironments enabled by peptidomimetics of cell-cell and cell-matrix ligands, with defined mechanical and adhesive properties that we will dynamically control in time and space trough photo-activation. The properties under force of the molecular bonds involved will be characterized using single-molecule atomic force microscopy and magnetic tweezers. At the cell-to-organ scale, we will combine controlled microenvironments and interfering strategies with the development of techniques to measure and control mechanical forces and adhesion in cells and tissues, and to evaluate their biological response. At the organism scale, we will establish how cellular mechanics can be controlled, by targeting specific adhesive interactions, to impair or abrogate breast tumour progression in a mouse model. At all stages and scales of the project, we will integrate experimental data with multi-scale computational modelling to establish the rules driving biological response to mechanics and adhesion. With this approach, we aim to develop specific therapeutic approaches beyond the current paradigm in breast cancer treatment. Beyond breast cancer, the general principles targeted by our technology will have high applicability in oncology, regenerative medicine and biomaterials.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
217600
|
The senses of islam: a cultural history of perception in the muslim world
|
The aim of SENSIS is to write a cultural history of the senses in Islam, by examining how the senses have been conceptualised, and calibrated, in a variety of Muslim environments. Sensory perception is not only a physical but also a cultural act: how people experience and understand sight, sound, smell, taste, and touch differs according to the historical, geographical, social and intellectual contexts in which perception occurs. Accordingly, this project comprehensively studies the Muslim sensorium, past and present.
The topic is timely and important because (1) questions relating to the sensorium inform, and often complicate, intercultural encounters as well as inner-Muslim debates over identity and alterity; (2) there is a critical need to examine the scholarly contention that Islam’s alleged denigration of vision undermines its ability to modernise; and (3) the hackneyed notion that Islam celebrates the senses, as opposed to a disembodied, rationalised West, is likewise in need of a thorough revision. No sustained, comprehensive reflection on these issues exists in current scholarship, whether in historical-critical, text-based Islamic Studies, the field of study in which this project is primarily located, or in any of its cognate disciplines.
Researchers in SENSIS (PI, 2 postdocs, 2 PhDs) will study the topic diachronically through the centuries as well as synchronically across diverse traditions of thought in Islam (in five subprojects: epistemology, mysticism, ethics, law, and aesthetics), thereby avoiding a monolithic, essentialising account of Islam’s attitude toward the senses. The project combines textual approaches in Islamic Studies with methods and theories from religious studies, anthropology, and the emerging field of sensory history. Additional financial support is solicited to facilitate five interdisciplinary workshops, each devoted to a sense organ, as well as a concluding, synaesthetic conference on the senses in Islam.
|
project/european
|
[
[
"Culture, Creativity and Inclusive Society"
]
] |
[
[
"Social and economic transformations",
"Culture, cultural heritage and creativity"
]
] |
220036
|
The role of strike-slip faults in the displacement of the Palaeotethys suture zone in Southeast Thailand
|
Abstract Six N–S tectono-stratigraphic belts can be recognized in Southeast Thailand, each with a distinct stratigraphy and igneous history. The westernmost Belt (I) is thought to be part of the Sibumasu Block, and the easternmost (V) to include part of the Indochina Block. Between those, Belt III comprises acid volcanic rocks, volcaniclastics, and Carboniferous to Triassic sedimentary rocks with distinctive faunas, interpreted to be a volcanic arc; Belt IV comprises Triassic rocks of back-arc basin origin; Belt V is interpreted as a Permian accretionary complex on the western flank of Indochina; and VI is an unconformable cover of Jurassic–Cretaceous red-beds correlating with the Khorat Group. A history of the Triassic Indosinian Orogeny is proposed, leading to the cratonization of Southeast Thailand by the end-Triassic. The apparent absence in Southeast Thailand of rocks from the Devonian–Triassic Palaeotethys ocean (the Inthanon Zone of Northern Thailand) is suggested to have resulted from a phase of post-Indosinian, oblique to longitudinal, sinistral, strike-slip faulting. That phase is thought to have included displacement on the Mae Yuam Fault which bounds the Inthanon Zone in Northern Thailand. Then followed a phase of transverse, sinistral, strike-slip faulting which offset the tectono-stratigraphic belts and faults of the earlier phase.
|
publication
|
[
[]
] |
[
[]
] |
W2057311563
|
Improvement of Façades' Sound Insulation of Schools near the Bergamo - Orio al Serio International Airport: Case Study
|
In recent years the acoustic qualification of buildings has gained more and more importance at international level. Building renovation is one of the most common ways to improve the acoustic quality of the existing buildings; in particular, schools buildings are the ones that need more attention. In this context, the sound insulation requirements, especially for buildings near airport zones, play a role of primary importance. This paper analyses the data of a campaign of inspections and on-site measurements of façade sound insulation, concerning five public school buildings, close to the international airport of Bergamo - Orio al Serio. The analysis consisted in checking the sound insulation of buildings, after selecting classrooms with common characteristics, based on an accurate preliminary investigation involving more than 395 different characteristics of frames and glass windows. After having determined the D 2 m,nT,w, the most appropriate technological solutions for a refurbishment project were determined. Finally, the improved façade sound insulation was verified. The refurbishment project took place in 15 classrooms, characterised by a pre-treatment D 2 m,nT,w lower than 38 dB. Experimental post-treatment results showed that all classrooms satisfied the required basic performance of D 2 m,nT,w, and 13 of them fulfilled the high performance requirement of 43 dB, established in the Italian acoustic classification.
|
publication
|
[
[
"Digital, Industry and Space",
"Civil Security for Society"
]
] |
[
[
"Circular systems"
]
] |
W2235106050
|
INJECTION MOLDABLE COMPOSITE
|
Composite moulable par injection comprenant un mélange de polyéthercétone tel qu'une résine matricielle de polyétheréthercétone, une matière de remplissage métallique telle qu'une fibre d'acier inoxydable revêtue d'une colle résinique soluble dans la résine matricielle, ainsi qu'une fibre de verre. La forme moulée obtenue du composite est électroconductrice et présente une compatibilité galvanique avec l'aluminium.
|
patent
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Advanced Materials",
"Manufacturing technologies"
]
] |
US 9101126 W
|
Medical device for automatic preparation of high quality foam for sclerotherapy of varicose veins
|
Approximately 25% of adults have varicose veins, with prevalence increasing to over 80% if spider veins are also considered. The rising geriatric population is further accelerating these figures, as one in two people over the age of 50 are affected by varicose veins. In recent years, due to the possibility of infection and other adverse effects during invasive surgeries, traditional surgical treatment (surgical ligation and stripping) has given way to minimally invasive procedures, which also reduce hospital stays and costs. Consequently, a growing number of doctors are adopting foam sclerotherapy, endovenous laser treatment, and radiofrequency ablation over conventional surgical practices. Within these new treatment approaches, foam sclerotherapy is the preferred approach given its favourable efficacy and safety profile coupled with simplicity and relatively low cost. Foam sclerotherapy involves transforming a chemical sclerosing agent into foam and injecting it into the affected vein. The sclerosant foam irritates the lining of the blood vessel, causing it to collapse and stick together. Current manual foam preparation method broadly utilized by doctors (Tessari’s method) presents substantial limitations in terms of quality, consistency, versatility, and safety. VARIXIO Sclerotherapy Microfoam System being developed by VB Devices addresses these limitations by automating, standardizing, and greatly simplifying foam preparation. VARIXIO adds versatility and safety to this obsolote treatment method. Having secured patent protection for the device and validated the concept at the prototype level, the company is seeking
funding to pursue industrial, regulatory, and commercial feasibility of the VARIXIO device.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Non-communicable and rare diseases",
"Healthcare systems",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
2718384
|
PYRAZOLOQUINAZOLINONES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
|
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV- induced skin damage, and as chemo- and/or radiosensitizers for cancer treatment.
|
patent
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases",
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
GB 2008050049 W
|
Prolonged Voluntary Running Negatively Affects Survival and Disease Prognosis of Male SOD1G93A Low-Copy Transgenic Mice
|
Amyotrophic Lateral Sclerosis (ALS) is a disease in which physical activity plays a controversial role. Epidemiological studies indicate an association between intense exercise and risk of developing ALS. To study the impact of physical activity on ALS, mouse models rely mostly on forced exercise. In this study we hypothesized that voluntary wheel running could represent a better model of the influence of exercise in the pathogenesis of ALS. We used an automated home-cage running-wheel system that enables individual monitoring of performance. To verify the effect of voluntary running on disease progression, prognosis and survival as well as motor functions, we challenged SOD1G93A low-copy male and female mice on one (1 RW, at age 24 weeks) or multiple (3 RW) running sessions at age 13, 18, and 24 weeks. In parallel we measured performance on Rotarod and Grip strength tests at different ages. Several parameters were analyzed through Principal Component Analysis in order to detect what indices correlate and may be useful for deeper understanding of the relation between exercise and disease development. We found mutant male mice more negatively affected than females by prolonged and repeated exercise. SOD1G93A low-copy male mice showed shorter survival, increased body weight loss and poorer disease prognosis when exposed to multiple running sessions. These findings could encourage the investigation of the pathogenetic mechanisms underlying the supposedly increased risk to develop ALS in humans engaged in specific and intense exercise activities.
|
publication
|
[
[
"Health"
]
] |
[
[
"Non-communicable and rare diseases"
]
] |
W2901586481
|
Mathematical model for estimating of technical and technological indicators of railway stations operation
|
Purpose. The article aims to create a mathematical model of the railway station functioning for the solving of problems of station technology development on the plan-schedule basis. Methodology. The methods of graph theory and object-oriented analysis are used as research methods. The model of the station activity plan-schedule includes a model of technical equipment of the station (plan-schedule net) and a model of the station functioning , which are formalized on the basis of parametric graphs. Findings. The presented model is implemented as an application to the graphics package AutoCAD. The software is developed in Visual LISP and Visual Basic. Taking into account that the construction of the plan-schedule is mostly a traditional process of adding, deleting, and modifying of icons, the developed interface is intuitively understandable for a technologist and practically does not require additional training. Originality. A mathematical model was created on the basis of the theory of graphs and object-oriented analysis in order to evaluate the technical and process of railway stations indicators; it is focused on solving problems of technology development of their work. Practical value. The proposed mathematical model is implemented as an application to the graphics package of AutoCAD. The presence of a mathematical model allows carrying out an automatic analysis of the plan-schedule and, thereby, reducing the period of its creation more than twice.
|
publication
|
[
[
"Digital, Industry and Space"
]
] |
[
[
"Key digital technologies",
"Advanced computing and big data",
"Manufacturing technologies"
]
] |
W2058921470
|
Ultrasound cavitation in soft materials
|
The pressures and temperatures developing during the interactions of shockwaves with cavitation bubbles and soft matter induce complex phenomena, both at physical and biochemical levels. These have a non- exhaustive range of relevant applications including ultrasound-based therapies, surface cleaning and food processing. Our aim is to explore these processes both in micro and macroscales using experiments and to develop new computational capabilities for their simulations. Measurements will include temperature/ species forming in collapsing bubbles, identifying chemical reactions and possible tissue interaction, such as protein denaturation and agglomeration; tissue cavitation threshold and its control using nanoparticles, allowing development of new cavitation-mimicking-tissue materials extrapolating to actual tissue properties that will be used for in-vitro testing of equipment with minimum collateral damages. Computations will be based on advanced multi-resolution methods coupling fluid flow, chemical reactions and deforming material mechanics solvers, with physically consistent thermodynamic closure models for the involved materials; pressure wave propagation, bubble nucleation and material damage effects will link microscale phenomena to macroscale. Uncertainty quantification techniques will link computations with experimental data. UCOM builds upon the strong foundations of the PIs and their teams in training researchers in computational and experimental methods on cavitation and their strong record to successfully integrate research and technical applications. The final goal of the research and training program is to explore the enormous potential of the new and experimentally validated computational tools to guide breakthrough innovations and high-impact, high-tech technologies ranging across different sectors that all eventually enhance their careers and will be serving the well-being.
|
project/european
|
[
[
"Health",
"Digital, Industry and Space"
]
] |
[
[
"Tools, technologies and digital solutions for health and care, including personalised medicine"
]
] |
888999
|
2D CFD Simulation of Water Injection Strategies in a Large Marine Engine
|
A two-dimensional computational fluid dynamics (2D CFD) simulation of a low-speed two-stroke marine engine simulation was performed in order to investigate the performance of 2D meshes that allow the use of more complex chemical schemes and pollutant formation analysis. Various mesh density simulations were compared with a 3D mesh simulation and with the experimentally obtained cylinder pressure. A heavy fuel model and a soot model were implemented in the software. Finally, the influences of three water injection strategies were simulated and evaluated in order to investigate the capability of the model and the influence of water injection on NOx formation, soot formation, and engine performance. We conclude that the direct water injection strategy reduces NOx emissions without adversely affecting the engine performance or soot emissions. The other two strategies—Intake air humidification and direct injection of fuel–water emulsion—reduced NOx emissions but at the cost of higher soot emissions or reduced engine performance.
|
publication
|
[
[
"Climate, Energy and Mobility",
"Digital, Industry and Space"
]
] |
[
[
"Clean, safe and accessible transport and mobility",
"Industrial competitiveness in transport",
"Energy systems and grids"
]
] |
W2970207162
|
Features of Mild-to-Moderate COVID-19 Patients With Dysphonia
|
To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients.The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general, and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and nondysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis.A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (P = 0.022). The proportion of smokers was significantly higher in the dysphonic group (P = 0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with nondysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea, and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain, and nasal obstruction was higher in dysphonic group compared with nondysphonic group. There were significant associations between the severity of dysphonia, dysphagia, and cough.Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than nondysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation.
|
publication
|
[
[
"Health"
]
] |
[
[
"Infectious diseases, including poverty-related and neglected diseases"
]
] |
W3032943795
|
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